The comparison of application of two different frequencies of TENS on excitability of Hoffmann reflex

OpenAIRE

Akbari M; Bagheri H; Olyaei G; Talebian S; Jafari F

2001-01-01

The aim of this investigation is to compare the effect of applying two transcutaneous electrical nerve stimulation (TENS) current with different frequencies (2 Hz & 100 Hz) on Hoffmann reflex recorded from gastrosoleus muscle of healthy people. Forty female subjects between 20 to 30 years of age were participated in this quasi-experimental design. Twenty of them were exposed to the 100 Hz current and the remaining 20 to 2 Hz current on dermatome S1 root. The excitability of the alpha ...

Don Juan: eine Tragödie. Intertestualità faustiana e riscrittura tragica nel racconto di E. T. A. Hoffmann

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Francesco Marola

2017-11-01

Full Text Available Il mito letterario di don Giovanni, sorto nella commedia, attorno al 1800 viene riformulato in direzione del tragico. La trasformazione inizia con la versione operistica di Mozart-Da Ponte e trova compimento nel racconto di Hoffmann, che proietta il nuovo tono tragico del finale mozartiano su tutto il mito. L’articolo intende porre in rilievo la presenza nel Don Juan di numerosi richiami intertestuali al Faust di Goethe, finora non pienamente rilevati dalla critica, attraverso i quali è possibile leggere tale riscrittura tragica come una dichiarata sintesi dei due miti, in cui don Giovanni assume il ruolo di Faust-Mefistofele e donna Anna quello di Gretchen. La riscrittura del mito culmina nel finale rispecchiamento del narratore in Anna-Gretchen. Ma il valore del tragico è relativizzato in Hoffmann dall’ironica autocoscienza dell’artista romantico: confinato nel mondo fantastico dell’arte, risulta privo di senso nella prosaica realtà della vita borghese.

Total intravenous anesthesia (TIVA) in an infant with Werdnig-Hoffmann disease. Case report.

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de Resende, Marco Antonio Cardoso; da Silva, Elizabeth Vaz; Nascimento, Osvaldo José Moreira; Gemal, Alberto Esteves; Quintanilha, Giseli; Vasconcelos, Eliana Maria

2010-01-01

Werdnig-Hoffmann disease is the most common cause of hypotonia in infants and its prognosis is worse if it is present shortly after delivery. Symmetrical muscular weakness, areflexia, and fasciculations of the tongue are characteristic. The majority of the infants die before two years of age as a consequence of respiratory failure. The present report presents a case in which total intravenous anesthesia was used. This is a 1 year old white female weighing 10 kg, physical status ASA III, with Werdnig-Hoffmann disease diagnosed at two months of age. The patient was a candidate for open gastrostomy, fundus gastroplication, and tracheostomy. After venoclysis, the patient was monitored with cardioscope, non-invasive blood pressure, pulse oximeter, precordial stethoscope, and rectal temperature. She was oxygenated and, after bolus administration of atropine (0.3 mg), boluses of remifentanil (20 microg) and propofol (30 mg) were administered for anesthetic induction. After tracheal intubation, she was ventilated with manual controlled system without CO(2) absorber, Baraka (Mapleson D system), FGF of 4 L.min(-1), and FiO(2) 0.5 (O(2)/N(2)O). Anesthesia was maintained with continuous manual infusion of propofol, 250 microg x kg(-1) x min(-1), and remifentanil, 0.3 microg x kg(-1) x min(-1). The surgery lasted 150 minutes. The patient regained consciousness 8 minutes after the end of the infusion, ventilating spontaneously. Two hours later, she was transferred to the pediatric unit, being discharged from the hospital on the fourth postoperative day. The choice of anesthetic technique gives priority to the safety associated with the familiarity of handling available drugs. In children with neuromuscular diseases, due to the extremely short duration, total intravenous anesthesia with remifentanil and propofol in infusion systems can have a favorable influence on disease evolution.

Anestesia venosa total (AVT) em lactente com doença de Werdnig-Hoffmann: relato de caso

OpenAIRE

Resende, Marco Antonio Cardoso de; Silva, Elizabeth Vaz da; Nascimento, Osvaldo José Moreira; Gemal, Alberto Esteves; Quintanilha, Giseli; Vasconcelos, Eliana Maria

2010-01-01

JUSTIFICATIVA E OBJETIVOS: A doença de Werdnig-Hoffmann é a causa mais comum de hipotonia no lactente e quando presente logo após o nascimento tem pior prognóstico. Fraqueza muscular simétrica, arreflexia e fasciculações da língua são característicos. A maioria dos lactentes morre antes dos dois anos por insuficiência respiratória. O presente relato apresenta um caso com técnica venosa total durante anestesia. RELATO DO CASO: Paciente feminina, branca, um ano, 10 kg, estado físico ASA III, co...

Poetry, Nature and Science: Romantic Nature Philosophy in the Works of Novalis and E. T. a. Hoffmann

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Weisend, Ausma Skerbele

The nature philosophy of the early Romantic period in Germany attempted to find a synthesis of science and philosophy in a new philosophy of nature. This philosophy was first formulated by F. W. J. Schelling and influenced by the galvanic experiments of J. W. Ritter. Novalis is a unique figure in romanticism since he combines scientific expertise with philosophical insight and poetic imagination. In Lehrlinge zu Sais he explores the significance of nature's language and presents different relationships between man and nature. Novalis thinks that a synthesis of all divergent elements in nature and society is necessary to transform the world. In Klingsohrs Marchen this transformation is accomplished by poetic activation of the physical sciences and by the power of love. After 1800 the romantic movement becomes interested in the problems of subconscious and abnormal psychological states, which are seen as contacts with a more spiritual level of existence. These ideas, expressed in a popular form by G. H. Schubert, provide a rich source of materials for E. T. A. Hoffmann, who elevates the realms of poetry and music in his fairy tales, but sees only negative qualities in science. Hoffmann's protagonists find that love, music, and poetry are the greatest forces in life. The figure of the scientist becomes an evil magician with no regard for human values. The romantic movement failed to unite the values of humanities with the insights of physical sciences. The problem of autonomy isolates both modern science and modern literature from the ethical values of society.

Lower Amplitude of the Hoffmann Reflex in Women With Patellofemoral Pain: Thinking Beyond Proximal, Local, and Distal Factors.

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de Oliveira Silva, Danilo; Magalhães, Fernando Henrique; Faria, Nathálie Clara; Pazzinatto, Marcella Ferraz; Ferrari, Deisi; Pappas, Evangelos; de Azevedo, Fábio Mícolis

2016-07-01

To investigate whether vastus medialis (VM) Hoffmann reflexes (H-reflexes) differ on the basis of the presence or absence of patellofemoral pain (PFP) and to assess the capability of VM H-reflex measurements in accurately discriminating between women with and without PFP. Cross-sectional study. Laboratory of biomechanics and motor control. Women (N=30) aged 18 to 35 years were recruited, consisting of 2 groups: women with PFP (n=15) and asymptomatic controls (n=15). Not applicable. Maximum evoked responses were obtained by electrical stimulation applied to the femoral nerve, and peak-to-peak amplitudes of maximal Hoffmann reflex (Hmax) and maximal motor wave (Mmax) ratios were calculated. Independent samples t tests were performed to identify differences between groups, and a receiver operating characteristic curve was constructed to assess the discriminatory capability of VM H-reflex measurements. VM Hmax/Mmax ratios were significantly lower in participants with PFP than in pain-free participants (P=.007). In addition, the VM Hmax/Mmax ratios presented large and balanced discriminatory capability values (sensitivity, 73%; specificity, 67%). This study is the first to show that VM H-reflexes are lower in women with PFP than in asymptomatic controls. Therefore, increasing the excitation of the spinal cord in PFP participants may be essential to maintaining the gains acquired during the rehabilitation programs. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

New ocular movement detector system as a communication tool in ventilator-assisted Werdnig-Hoffmann disease.

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Kubota, M; Sakakihara, Y; Uchiyama, Y; Nara, A; Nagata, T; Nitta, H; Ishimoto, K; Oka, A; Horio, K; Yanagisawa, M

2000-01-01

A non-contact communication system was developed for a ventilator-assisted patient with Werdnig-Hoffmann disease who had lost all voluntary movements except for those of the eye. The system detects the extraocular movements and converts them to either a 'yes' signal (produced by one lateral eyeball movement) or a 'no' signal (produced by two successive lateral eyeball movements) using a video camera placed outside the patient's visual field. The patient is thus able to concentrate on performing a task without any intrusion from the detection system. Once the setting conditions of the device have been selected, there is no need for any resetting, as the patient is unable to move his body. In addition to playing television games, the child can use the device to select television channels, compose music, and learn written Japanese and Chinese characters. This seems to broaden the patient's daily world and promote mental development.

A figura do gato como capa para considerações mais profundas : Lope de Vega, E. T. A. Hoffmann, T. S. Eliot

OpenAIRE

Zamith, Maria Cândida

2014-01-01

Cats have traditionally been writers' favourite pets. And writers who love cats often write about them or in their names. Among many others, Lope de Vega, E. T. A. Hoffmann and T. S. Eliot did. It is fascinating to analyse how three very different authors, living centuries apart in distinct countries, and writing different kinds of poetry or prose, found a similar way to express their opinions or secret grievances about women's inconstancy and the fallacy of love vows. The three of them lent ...

The muscle CT of thigh in chronic Werdnig-Hoffmann disease

International Nuclear Information System (INIS)

Horikawa, Hirosei; Konagaya, Masaaki; Takayanagi, Tetsuya; Otsuji, Hideaki

1986-01-01

In this paper, the muscle CT of thigh in chronic Werdnig-Hoffmann disease (chronic WH) was evaluated. The subjects were five cases of chronic WH (3 males and 2 females, ages ranging from 6 to 22 years) and four control males. All cases showed symmetrical muscular weakness. The proximal muscle were more affected than the distal in the upper limbs. But the muscle strength of hip adduction was relatively spared as compared with other strength of lower limbs. The CT scan was carried out at the upper quarter level between lesser trochanter and medial condyle of the femur. The muscle CT of cases aged 6 and 7 years showed the severely decreased cross-sectional area of muscle without significant decrease in density. The atrophic muscles were surrounded by a large amount of low density area. The hamstring muscles and the adductor muscles, especially adductor longus muscle (ALM), were less affected than the quadriceps femoris muscles. Spotty and moth-eaten low density areas were observed dominantly in the severely affected muscles. In the advanced cases, only ALM could be identified on the CT image. The other muscles were unable to be identified because of severe atrophy with extremely low density. These CT findings suggest the process of muscular wastings of chronic WH as follows; at first muscle fibers are atrophied due to denervation and sooner or later replaced with fat tissue. Moreover, the preservation of ALM suggests that loss of anterior horn cells does not always go on homogeneously. (author)

On machines and instruments (I: The automaton’s body in the work of E.T.A. Hoffmann

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Montiel, Luis

2008-06-01

Full Text Available Immediately after becoming interested in animal magnetism, and undoubtedly as a result of this interest, E.T.A. Hoffmann used automata as the central characters in some of his most notable works. This paper aims to show how this interest reveals the author’s critical attitude towards a conception of the human being which, developing in parallel to anatomy-based medicine, had led in the eighteenth century to a doctrine whose most complete expression is to be found in L'homme machine, by J. O. De La Mettrie. Nowadays we can see these tales, like those dedicated to animal magnetism, as a cry of alarm against one of the consequences of such a mechanical conception of a human being: the growth of «biopower», or of «biopolitics», terms coined by Foucault in his last works; but also against the risks entailed by the Promethean drive of modernity.

Inmediatamente después de interesarse por el magnetismo animal, y seguramente como consecuencia de dicho interés, E.T.A. Hoffmann hizo de los autómatas personajes centrales en algunas de sus obras más notables. El presente trabajo pretende mostrar cómo este interés revela la actitud crítica del escritor hacia un modo de concebir al ser humano que, desarrollándose paralelamente a una medicina basada en la anatomía, había desembocado en el siglo XVIII en un estado de opinión que tiene su más acabada expresión en L’homme machina, de J. O. De La Mettrie. Estos relatos, como los dedicados al magnetismo animal, nos parecen hoy un grito de alerta frente a una de las consecuencias de esa concepción mecánica del ser humano: el despliegue del «biopoder», o de la «biopolítica», conceptos formulados por Foucault en sus últimas obras; pero también frente a los riesgos que entraña la voluntad prometeica de la modernidad.

Testing general relativity with compact-body orbits: a modified Einstein–Infeld–Hoffmann framework

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Will, Clifford M.

2018-04-01

We describe a general framework for analyzing orbits of systems containing compact objects (neutron stars or black holes) in a class of Lagrangian-based alternative theories of gravity that also admit a global preferred reference frame. The framework is based on a modified Einstein–Infeld–Hoffmann (EIH) formalism developed by Eardley and by Will, generalized to include the possibility of Lorentz-violating, preferred-frame effects. It uses a post-Newtonian N-body Lagrangian with arbitrary parameters that depend on the theory of gravity and on ‘sensitivities’ that encode the effects of the bodies’ internal structure on their motion. We determine the modified EIH parameters for the Einstein-Æther and Khronometric vector-tensor theories of gravity. We find the effects of motion relative to a preferred universal frame on the orbital parameters of binary systems containing neutron stars, such as a class of ultra-circular pulsar-white dwarf binaries; the amplitudes of the effects depend upon ‘strong-field’ preferred-frame parameters \\hatα1 and \\hatα2 , which we relate to the fundamental modified EIH parameters. We also determine the amplitude of the ‘Nordtvedt effect’ in a triple system containing the pulsar J0337+1715 in terms of the modified EIH parameters.

Síndrome de Werdnig-Hoffmann (atrofia muscular espinal de la infancia). Presentación de un caso y revisión en la literatura

OpenAIRE

Jairo Claret Rodríguez Hernández, MD; Eder Ariel Lancheros García; Silvia Cristina Martínez Rueda

2010-01-01

El síndrome de Werdnig-Hoffmann o atrofia muscular espinal (AME) de la infancia es una enfermedad de patrón autosómico recesivo de origen neuromuscular y degenerativo, poco prevalente en la población general, y que se caracteriza por la destrucción de las neuronas motoras del asta anterior de la medula espinal debido a alteraciones cromosómicas.La enfermedad no tiene tratamiento, es de mal pronóstico y, por lo general, culmina con la muerte del menor en los primeros años de vida por dificulta...

Anestesia venosa total (AVT em lactente com doença de Werdnig-Hoffmann: relato de caso Anestesia venosa total (AVT en lactante con enfermedad de Werdnig-Hoffmann: relato de caso Total intravenous anesthesia (TIVA in an infant with Werdnig-Hoffmann disease: case report

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Luis Otavio Esteves

2010-10-01

Full Text Available Foi com grande interesse que li o artigo "Anestesia Venosa Total (AVT em Lactente com Doença de Werdnig-Hoffmann. Relato de Caso", de Resende e col. ¹, publicado nesta revista. Gostaria, em primeiro lugar, de parabenizar os autores pela iniciativa. Entretanto, dois pontos me chamaram a atenção. O primeiro refere-se à definição de lactente, a qual compreende o período de 1 a 12 meses de idade. A partir de 12 meses, define-se como pré-escolar ou apenas criança. No artigo, o autor coloca a idade do paciente como 1 ano, mas não especifica meses ou dias. Provavelmente, esse paciente tem mais de 12 meses, sendo, dessa forma, a definição de lactente inadequada. O segundo e mais importante ponto diz respeito à técnica usada e ao título do artigo. No título, utilizou-se a expressão "anestesia venosa total", mas no relato foi dito que, além de propofol e remifentanil, a anestesia foi mantida com oxigênio e N2O. Se foi usado um gás com propriedades anestésicas (N2O, não seria correto classificar essa técnica como venosa total. Além disso, ele cita o artigo de Crawford e col. ², que definiu doses de remifentanil para intubação em crianças. Esse estudo foi realizado utilizando-se oxigenação na concentração de 100%, pois os autores provavelmente entendem que a adição de gases com propriedades anestésicas interferiria nos resultados obtidosFue con un gran interés que leí el artículo "Anestesia Venosa Total (AVT en Lactante con Enfermedad de Werdnig-Hoffmann. Relato de Caso", de Resende y col. ¹, publicado en esta revista. Y de hecho quiero, en primer lugar, felicitar a los autores por la iniciativa. Sin embargo, dos puntos me llamaron la atención. El primero, se refiere a la definición de lactante, la cual abarca el período de 1 a 12 meses de edad. A partir de los 12 meses, se define como preescolar o apenas como niño. En el artículo, el autor coloca la edad del paciente como de 1 año, pero no especifica meses o d

Short-term locomotor adaptation to a robotic ankle exoskeleton does not alter soleus Hoffmann reflex amplitude.

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Kao, Pei-Chun; Lewis, Cara L; Ferris, Daniel P

2010-07-26

To improve design of robotic lower limb exoskeletons for gait rehabilitation, it is critical to identify neural mechanisms that govern locomotor adaptation to robotic assistance. Previously, we demonstrated soleus muscle recruitment decreased by approximately 35% when walking with a pneumatically-powered ankle exoskeleton providing plantar flexor torque under soleus proportional myoelectric control. Since a substantial portion of soleus activation during walking results from the stretch reflex, increased reflex inhibition is one potential mechanism for reducing soleus recruitment when walking with exoskeleton assistance. This is clinically relevant because many neurologically impaired populations have hyperactive stretch reflexes and training to reduce the reflexes could lead to substantial improvements in their motor ability. The purpose of this study was to quantify soleus Hoffmann (H-) reflex responses during powered versus unpowered walking. We tested soleus H-reflex responses in neurologically intact subjects (n=8) that had trained walking with the soleus controlled robotic ankle exoskeleton. Soleus H-reflex was tested at the mid and late stance while subjects walked with the exoskeleton on the treadmill at 1.25 m/s, first without power (first unpowered), then with power (powered), and finally without power again (second unpowered). We also collected joint kinematics and electromyography. When the robotic plantar flexor torque was provided, subjects walked with lower soleus electromyographic (EMG) activation (27-48%) and had concomitant reductions in H-reflex amplitude (12-24%) compared to the first unpowered condition. The H-reflex amplitude in proportion to the background soleus EMG during powered walking was not significantly different from the two unpowered conditions. These findings suggest that the nervous system does not inhibit the soleus H-reflex in response to short-term adaption to exoskeleton assistance. Future studies should determine if the

Basicladia chelonum (Collins W.E. Hoffmann et Tilden (Chlorophyta, Cladophorophyceae from Cuba (Caribbean: new observation of the ultrastructure of its vegetative cells

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Joanna Czerwik-Marcinkowska

2011-01-01

Full Text Available Basicladia chelonum (Collins W.E. Hoffmann and Tilden (1930 principally known from North America and Hawaii was recently (2004 found in Cuba (Caribbean from artificial pool growing on shells of musk turtles (Trachemys decussata Gray. Specimens collected in Cuba were subjected to detailed examinations also using a transmission electron microscope. On one hand, these studies confirmed many features of this species previously described by earlier authors in the specimens from Texas. On the other hand, the present studies revealed structures unknown so far (pyrenoid structure, which allowed for new analysis of this species. These investigations also have shown that Basicladia chelonum exhibits close similarity to the genus Cladophora and other representatives of the class Cladophorophyceae. The similarities include : siphonocladous level of organization of thallus, numerous chloroplasts forming a network and other structures. Conversely, the pyrenoid in vegetative cells of Basicladia chelonum distinguishes it markedly from representatives of the genus Cladophora, which have bilenticular pyrenoids divided into two hemispheres by a single thylakoids and each hemisphere is covered by a bowlshaped starch grain (Van Hoek et al. 1995. Since in Cladophora the ultrastructure of the pyrenoid is highly constant and characteristic, this contrasts with the genus Basicladia and, therefore, more firmly establishes position of the latter as an independent unit within Cladophorophyceae.

Walén test and de Hoffmann-Teller frame of interplanetary large-amplitude Alfvén waves

International Nuclear Information System (INIS)

Chao, J. K.; Hsieh, Wen-Chieh; Lee, L. C.; Yang, L.

2014-01-01

In this study, three methods of analysis are compared to test the Walén relation. Method 1 requires a good de Hoffmann-Teller (HT) frame. Method 2 uses three components separately to find the frame that is slightly modified from Method 1. This method is intended to improve the accuracy of the HT frame and able to demonstrate the anisotropic property of the fluctuations. The better the relation is, the closer the slope of a regression fitting the data of plasma versus Alfvén velocities is to 1. However, this criterion is based on an average HT frame, and the fitted slope does not always work for the Walén test because the HT frame can change so fast in the high-speed streams. We propose Method 3 to check the Walén relation using a sequence of data generated by taking the difference of two consecutive values of plasma and Alfvén velocities, respectively. The difference data are independent of the HT frame. We suggest that the ratio of the variances between plasma and Alfvén velocities is a better parameter to qualify the Walén relation. Four cases in two solar wind streams are studied using these three methods. Our results show that when the solar wind HT frame remains stable, all three methods can predict Alfvénic fluctuations well, but Method 3 can better predict the Walén relation when solar wind contains structures with several small streams. A simulated case also demonstrates that Method 3 is better and more robust than Methods 1 and 2. These results are important for a better understanding of Alfvénic fluctuations and turbulence in the solar wind.

Is there a logical slippery slope from voluntary to nonvoluntary euthanasia?

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Jones, David Albert

2011-12-01

John Keown has constructed a logical slippery slope argument from voluntary euthanasia (VAE) to nonvoluntary euthanasia (NVAE). VAE if justified implies that death can be of overall benefit, in which case it should also be facilitated in those who cannot consent (NVAE). Hallvard Lillehammer asserts that Keown's argument rests on a fallacy. However, pace Lillehammer, it can be restated to escape this fallacy. Its validity is confirmed by applying to VAE some well-established general principles of medical decision making. Thus, either VAE and NVAE must be accepted together or, if NVAE is regarded as unacceptable, VAE should also be rejected.

Facilitation of Hoffmann reflexes of ankle muscles in prone but not standing positions by focal ankle-joint cooling.

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Kim, Kyung-Min; Ingersoll, Christopher D; Hertel, Jay

2015-05-01

Focal ankle-joint cooling (FAJC) has been shown to increase Hoffmann (H) reflex amplitudes of select leg muscles while subjects lie prone, but it is unknown whether the neurophysiological cooling effects persist in standing. To assess the effects of FAJC on H-reflexes of the soleus and fibularis longus during 3 body positions (prone, bipedal, and unipedal stances) in individuals with and without chronic ankle instability (CAI). Crossover. Laboratory. 15 young adults with CAI (9 male, 6 female) and 15 healthy controls. All subjects received both FAJC and sham treatments on separate days in a randomized order. FAJC was accomplished by applying a 1.5-L plastic bag filled with crushed ice to the ankle for 20 min. Sham treatment involved room-temperature candy corn. Maximum amplitudes of H-reflexes and motor (M) waves were recorded while subjects lay prone and then stood in quiet bipedal and unipedal stances before and immediately after each treatment. Primary outcome measures were H(max):M(max) ratios for the soleus and fibularis longus. Three-factor (group × treatment condition × time) repeated-measures ANOVAs and Fisher LSD tests were performed for statistical analyses. Significant interactions of treatment condition by time for prone H(max):M(max) ratios were found in the soleus (P = .001) and fibularis longus (P = .003). In both muscles, prone H(max):M(max) ratios moderately increased after FAJC but not after sham treatment. The CAI and healthy groups responded similarly to FAJC. In contrast, there were no significant interactions or main effects in the bipedal and unipedal stances in either muscle (P > .05). FAJC moderately increased H-reflex amplitudes of the soleus and fibularis longus while subjects were prone but not during bipedal or unipedal standing. These results were not different between groups with and without CAI.

Modulation of the Fibularis Longus Hoffmann Reflex and Postural Instability Associated With Chronic Ankle Instability

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Kim, Kyung-Min; Hart, Joseph M.; Saliba, Susan A.; Hertel, Jay

2016-01-01

Context: Individuals with chronic ankle instability (CAI) present with decreased modulation of the Hoffmann reflex (H-reflex) from a simple to a more challenging task. The neural alteration is associated with impaired postural control, but the relationship has not been investigated in individuals with CAI. Objective: To determine differences in H-reflex modulation and postural control between individuals with or without CAI and to identify if they are correlated in individuals with CAI. Design: Descriptive laboratory study. Setting: Laboratory. Patients or Other Participants: A total of 15 volunteers with CAI (9 males, 6 females; age = 22.6 ± 5.8 years, height = 174.7 ± 8.1 cm, mass = 74.9 ± 12.8 kg) and 15 healthy sex-matched volunteers serving as controls (9 males, 6 females; age = 23.8 ± 5.8 years, height = 171.9 ± 9.9 cm, mass = 68.9 ± 15.5 kg) participated. Intervention(s): Maximum H-reflex (Hmax) and motor wave (Mmax) from the soleus and fibularis longus were recorded while participants lay prone and then stood in unipedal stance. We assessed postural tasks of unipedal stance with participants' eyes closed for 10 seconds using a forceplate. Main Outcome Measure(s): We normalized Hmax to Mmax to obtain Hmax : Mmax ratios for the 2 positions. For each muscle, H-reflex modulation was quantified using the percentage change scores in Hmax : Mmax ratios calculated from prone position to unipedal stance. Center-of-pressure data were used to compute 4 time-to-boundary variables. Separate independent-samples t tests were performed to determine group differences. Pearson product moment correlation coefficients were calculated between the modulation and balance measures in the CAI group. Results: The CAI group presented less H-reflex modulation in the soleus (t26 = −3.77, P = .001) and fibularis longus (t25 = −2.59, P = .02). The mean of the time-to-boundary minima in the anteroposterior direction was lower in the CAI group (t28 = −2.06, P = .048

Una especie nueva de alacrán del género Centruroides de importancia médica (Scorpiones: Buthidae del estado de Guerrero, México A new scorpion species of medical importance of the genus Centruroides (Scorpiones: Buthidae from the state of Guerrero, Mexico

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José Guadalupe Baldazo-Monsivaiz

2013-03-01

Full Text Available Se describe Centruroides villegasi sp. nov. del municipio de Chilapa de Álvarez, Guerrero, que es la novena especie de Centruroides registrada para el estado. Se compara con C. limpidus (Karsch, 1879 por su parecido morfológico y por habitar la misma zona geográfica. Se compara también con C. balsasensis Ponce y Francke, 2004, C. meisei Hoffmann, 1938 y C. tecomanus Hoffmann, 1932, por pertenecer al grupo "alacranes rayados" (sensu Hoffmann, 1932, por su parecido morfológico y por su registro en Guerrero. Es una especie de importancia médica que no se había recolectado o reconocido previamente. Se incluye una lista de las especies de alacranes reconocidas para Guerrero, después de actualizar datos y hacer las correcciones necesarias a los registros históricos para el estado.Centruroides villegasi sp. nov. from the municipality of Chilapa de Álvarez, Guerrero, Mexico is described. It is the nineth species of Centruroides reported for this state. The new species is compared with C. limpidus (Karsch, 1879 which is morphologically similar and inhabits the same geographic zone. The species C. balsasensis Ponce and Francke, 2004, C. meisei Hoffmann, 1938, and C. tecomanus Hoffmann, 1932 are also compared because they are found in Guerrero and belong to the "striped scorpions" group (sensu Hoffmann, 1932, and therefore they are morphologically similar to the new species. It is a species of medical importance that had not been collected or recognized previously. A list of species of scorpions recorded for the state of Guerrero is included after the revision and correction of historical records.

Evaluation of the Safety and Efficacy of Excimer Laser Keratorefractive Surgery in U.S. Army Soldiers using the latest Battlefield Technologies

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2007-04-01

Kossendrup D, Wiederholt M, Hoffmann F. Influence of cyclosporin A, dexamethasone, and benzalkonium chloride (BAK) on corneal epithelial wound healing...1032–1037. 3. Kossendrup D, Wiederholt M, Hoffmann F. Influence of cyclosporin A, dexamethasone, and benzalkonium chloride (BAK) on corneal...efficacy of WFG LASIK and WFG PRK by assessing improvement of uncorrected visual acuity, achievement of intended refractive correction, and reduction of

Hoffmann's syndrome: a case report

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Ibrahim, Mohammad

2005-07-01

Full Text Available This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse voice, difficulty in walking and progressive enlargement of muscles of thighs and back with crampy pains for two years. Examination revealed mild mental retardation, enlarged tongue, dry and rough skin, enlargement of thighs and back muscles, motor weakness in flexors of hips and knees with delayed relaxation of deep tendon reflexes. Investigations revealed evidence of hypothyroidism with marked elevation of muscle enzymes. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass. In this report we review relevant literature.

Há 100 anos, a descoberta do Treponema pallidum A hundred years ago, the discovery of Treponema pallidum

Directory of Open Access Journals (Sweden)

Elemir Macedo de Souza

2005-10-01

Full Text Available A descoberta do Treponema pallidum por Schaudinn & Hoffmann em 3 de março de 1905 foi influenciada pela comunicação de Siegel, sobre a descoberta do agente etiológico da sífilis. Encarada com ceticismo, a comunicação acarretou novas investigações, conduzidas pelo zoologista Schaudinn e pelo dermatologista Hoffmann -primeiros observadores do agente da sífilis, denominado Spirochaeta pallida. A descoberta foi o passo inicial para o desenvolvimento dos procedimentos diagnósticos e terapêuticos nos anos subseqüentes.The discovery of Treponema pallidum by Schaudinn & Hoffmann, on March 3rd 1905, was influenced by Siegels' communication on the finding of the etiological agent of syphilis. John Siegel, working at the Institut of Zoology, University of Berlin, claimed to have found a flagellate protozoon in syphilitic lesions. Because of the skepticism it was received with, this communcation yielded further investigation, conducted by zoologist Schaudinn and dermatologist Hoffmann. They were the first investigators to find the etiological agent of syphilis, described under the name of Spirochaeta pallida. The discovery of Treponema pallidum on March 3rd 1905 was the first step towards the development of diagnostic and therapeutic procedures in subsequent years.

Effects of Formulated Glyphosate and Adjuvant Tank Mixes on Atomization from Aerial Application Flat Fan Nozzles

Science.gov (United States)

2012-01-01

Bradley K. Fritz,1 W. Clint Hoffmann,1 and W. E. Bagley2 Effects of Formulated Glyphosate and Adjuvant Tank Mixes on Atomization from Aerial...Application Flat Fan Nozzles REFERENCE: Fritz, Bradley K., Hoffmann, W. Clint, and Bagley, W. E., “Effects of Formulated Glyphosate and Adjuvant Tank Mixes on...factors. Twelve spray-solution treatments were evaluated, ten of which contained a formulated glyphosate product and nine of these con- tained an

The Genus Ixodes (Acari: Ixodidae) in Mexico: Adult Identification Keys, Diagnoses, Hosts, and Distribution (El genero Ixodes (Acari: Ixodidae) en Mexico: claves de identificacion para adultos, diagnosis, huespedes y distribucion)

Science.gov (United States)

2010-01-01

also from Estado de México (Hoffmann, 1969). Hosts in Mexico. Cricetidae and Hominidae ( Homo sapiens Linnaeus, 1758) (Mammalia) (Hoffmann, 1969...distribution El género Ixodes (Acari: Ixodidae) en México: claves de identifi cación para adultos, diagnosis, huéspedes y distribución Carmen Guzmán...postdoctoral scholarship under the Programa de Formación e Incorporación de Profesores de Carrera en Facultades y Escuelas para el Fortalecimiento de la

Integrated energy data solution for energy markets of Europe: Energy Data Warehouse; Integrierte Energiedatenloesung fuer Europas Energiemaerkte: Energy Data Warehouse

Energy Technology Data Exchange (ETDEWEB)

Anon.

2001-07-01

According to Ralf Hoffmann, head of the sales department of Goerlitz Computerbau AG, integrated problem solutions for Europe's new energy markets must be developed fast, without delay and with all efforts available. [German] 'Integrierte Problemloesungen fuer Europas neue Energiemaerkte muessen schnell und investitionssicher fuer die Anwender realisiert werden. Sie dulden keinen Aufschub. Alle unternehmerische Kraft muss und wird in die Befriedigung dieser Anforderungen gelegt.' So aeussert sich der Vorstand Absatzwirtschaft der Goerlitz Computerbau AG, Ralf Hoffmann. (orig.)

Woodward–Hoffmann Rules At Your Fingertips!

Indian Academy of Sciences (India)

In the idealised transition state, the orbital on the migrating hydrogen and the p orbitals of the π unit form a Hückel framework (Figure 6). Counting the electrons in the migrating σ bond and those in the π part, it is clear that [1,3]-hydride shift is. Figure 6. Typical sigma- tropic shifts are shown. The topology of the interacting.

Carcinoembryonic antigen (CEA)

International Nuclear Information System (INIS)

Ephraim, K.H.; Cox, P.H.; Hamer, C.J.A. v.d.; Berends, W.; Delhez, H.

1977-01-01

The carcinoembryonic antigen (CEA) is a complex of antigen determinants and also the carrier of these determinants. Chemically it is a glycoprotein. Its occurrence in blood serum or urine is correlated with malignant disease. Several radioimmunoassays (RIA) have been developed, one by Hoffmann-Laroche and one by the Rotterdam Radiotherapeutic Institute. Both methods and the Hoffmann assay kit are tested. Specifications are given for isolation of the antigen, preparation of the antiserum, and the execution of the RIA. Biochemical and clinical aspects are discussed

Computational Identification and Analysis of Signaling Subnetworks with Distinct Functional Roles in the Regulation of TNF Production

Science.gov (United States)

2016-01-04

extract four distinct quantitative features of response timing and intensity: the trajectory peak height, the peak time, the area under the curve, and...J., 2007, 21, 325–332. 16 S. L. Werner, J. D. Kearns, V. Zadorozhnaya, C. Lynch, E. O’Dea, M. P. Boldin , A. Ma, D. Baltimore and A. Hoffmann, Genes...Werner, J. D. Kearns, V. Zadorozhnaya, C. Lynch, E. O’Dea, M. P. Boldin , A. Ma, D. Baltimore and A. Hoffmann, Genes Dev., 2008, 22, 2093–2101. 58 J

Especie nueva de alacrán del género Centruroides (Scorpiones: Buthidae de la costa del estado de Jalisco, México A new scorpion species of the genus Centruroides (Scorpiones: Buthidae from the coast of the state of Jalisco, Mexico

Directory of Open Access Journals (Sweden)

Javier Ponce-Saavedra

2011-12-01

Full Text Available Se describe Centruroides chamela sp. nov. de Chamela en el estado de Jalisco, México. Se compara con C. elegans (Thorell, especie con la que es simpátrida. También se compara con las especies morfológica y geográficamente más cercanas: C. mascota Ponce-Saavedra y Francke, C. hirsutipalpus Ponce-Saavedra y Francke y C. tecomanus Hoffmann. Además, con C. meisei Hoffmann, que habita en las costas de Guerrero, porque este taxón se había considerado como subespecie de C. elegans. En la comparación se incluyen C. infamatus (C.L. Koch y C. ornatus (Pocock, por ser especies "rayadas" registradas para el estado de Jalisco.Centruroides chamela sp. nov. from Chamela, Jalisco, Mexico is described. The new species is compared primarily with C. elegans Thorell, because both species are sympatric. It is also compared with C. mascota Ponce-Saavedra et Francke, C. hirsutipalpus Ponce-Saavedra et Francke and C. tecomanus Hoffmann which are morphologically and geographically nearest to the new species. Centruroides meisei Hoffmann, which inhabits the coast of Guerrero is compared because this species was previously classified as a subspecies of C. elegans. Finally, C. infamatus (C.L. Koch and C. ornatus (Pocock are included in the comparisons because they are also present in the state of Jalisco, and belong to the "striped" section of the genus.

About vectors

CERN Document Server

Hoffmann, Banesh

1975-01-01

From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

Verification of models for ballistic movement time and endpoint variability.

Science.gov (United States)

Lin, Ray F; Drury, Colin G

2013-01-01

A hand control movement is composed of several ballistic movements. The time required in performing a ballistic movement and its endpoint variability are two important properties in developing movement models. The purpose of this study was to test potential models for predicting these two properties. Twelve participants conducted ballistic movements of specific amplitudes using a drawing tablet. The measured data of movement time and endpoint variability were then used to verify the models. This study was successful with Hoffmann and Gan's movement time model (Hoffmann, 1981; Gan and Hoffmann 1988) predicting more than 90.7% data variance for 84 individual measurements. A new theoretically developed ballistic movement variability model, proved to be better than Howarth, Beggs, and Bowden's (1971) model, predicting on average 84.8% of stopping-variable error and 88.3% of aiming-variable errors. These two validated models will help build solid theoretical movement models and evaluate input devices. This article provides better models for predicting end accuracy and movement time of ballistic movements that are desirable in rapid aiming tasks, such as keying in numbers on a smart phone. The models allow better design of aiming tasks, for example button sizes on mobile phones for different user populations.

78 FR 68476 - Notice of Lodging of Proposed Consent Decree Under the Comprehensive Environmental Response...

Science.gov (United States)

2013-11-14

..., General Electric Company, GlaxoSmithKline, LLC, Goodrich Corporation, HCR ManorCare, Inc., Hoffmann-La..., Inc., L.E. Carpenter & Company, LANXESS Corporation, Mack Trucks, Inc., Merck & Co., Inc., Momentive...

76 FR 59141 - Determination That LOXITANE (Loxapine Succinate) Capsules and Three Other Drug Products Were Not...

Science.gov (United States)

2011-09-23

... Applicant NDA 017525 LOXITANE (loxapine Watson Laboratories succinate) Inc., 417 Wakara Capsules, Way, Suite.../milliliter. NDA 020828 FORTOVASE Hoffmann La Roche (saquinavir) Inc., 340 Kingsland Capsule, 200 mg. St...

Nueva especie de alacrán del género Centruroides (Scorpiones, Buthidae del estado de Jalisco, México A new scorpion species of the genus Centruroides (Scorpiones, Buthidae from the state of Jalisco, Mexico

Directory of Open Access Journals (Sweden)

Javier Ponce Saavedra

2011-06-01

Full Text Available Se describe Centruroides mascota sp. nov. de Mascota, Estado de Jalisco, México. Se hace una comparación con las especies morfológica y geográficamente más cercanas: C. elegans Thorell, C. hirsutipalpus Ponce y Francke, C. infamatus (Koch., C. ornatus Pocock y C. tecomanus Hoffmann. Es una especie de importancia médica que no se había recolectado o reconocido previamente.Centruroides mascota sp. nov. from Mascota, Jalisco, Mexico is described. The new species is compared with C. elegans Thorell, C. hirsutipalpus Ponce y Francke, C. infamatus (Koch., C. ornatus Pocock and C. tecomanus Hoffmann, which are morphologically and geographically nearest to it. This medically important species had not been collected or recognized previously

Ginsbergi vennaskond, värskelt ühendatud / Marko Mägi

Index Scriptorium Estoniae

Mägi, Marko

2005-01-01

Poetry slami laadis luuleõhtul "Poesie United" esinesid 21. mail KuKu klubis Wehwalt Koslovsky, Tobias Hoffmann (Saksamaa), Ben Porter Lewis, Milo Martin (USA), Antoine Faure (Prantsusmaa), fs, Asko Künnap, Jürgen Rooste

Descripción de una especie nueva de alacrán con importancia médica del género Centruroides (Scorpiones: Buthidae del estado de Colima, México Description of a new species of scorpion of medical importance of the genus Centruroides (Scorpiones: Buthidae from the state of Colima, Mexico

Directory of Open Access Journals (Sweden)

Javier Ponce-Saavedra

2009-12-01

Full Text Available Se describe Centruroides hirsutipalpus sp. nov. de la región de Minatitlán, Colima. Se compara con las especies morfológica y geográficamente más cercanas, C. elegans Thorell y C. tecomanus Hoffmann y con otras especies "rayadas" de Centruroides del centro-occidente de México. Es ésta una especie con importancia médica que no se había recolectado previamente.Centruroides hirsutipalpus sp. nov. from the region of Minatitlán, Colima, Mexico is described. The new species is compared with C. elegans Thorell and C. tecomanus Hoffmann, which are morphologically and geographically closely related. Comparisons with other species of "striped" Centruroides from central and western Mexico are included. This medically important species had not been collected previously.

Genetics Home Reference: 2-hydroxyglutaric aciduria

Science.gov (United States)

... Ben-Omran T, Hoffmann GF, de Lonlay P, McDonald MT, Meberg A, Muntau AC, Nuoffer JM, Parini ... 10 All Bulletins Features What is direct-to-consumer genetic testing? What are genome editing and CRISPR- ...

Poesie United toob kirjanduspeo

Index Scriptorium Estoniae

2005-01-01

23. mail toimub Tartus rahvusvaheline kirjanduspidu "International spoken word subversion 2005" eesti, saksa, prantsuse ja ameerika sõnakunstnikega: Wehwalt Koslovsky, Tobias Hoffmann, Ben Porter Lewis, Milo Martin, Antoine Faure. Vt ka Postimees, 21. mai, lk. 26

Who says no to a good cup of joe? / Kristi Martin

Index Scriptorium Estoniae

Martin, Kristi

2016-01-01

Tutvustus: Moldvaer, Anette. Coffee Obsession. London, 2014; Hoffmann, James. The world atlas of coffee. London, 2014; Steiman, Shawn. The Little Coffee Know-It-All. Massachusetts, 2015; Stephenson, Tristan. The Curious Barista's Guide to Coffee. London, 2015

Maru ühendatud : Poesie United esines Tartus / Priit Kruus

Index Scriptorium Estoniae

Kruus, Priit

2005-01-01

23. mail esinesid Tartus saksa, ameerika, prantsuse ja eesti luuletajad spoken word-kirjandusüritusega "Poesie united". Osalesid Wehwalt Koslovsky, Tobias Hoffmann, Milo Martin, Ben Porter Lewis, Antoine Faure, Jürgen Rooste, Asko Künnap ja fs

Symbols for the General British English Vowel Sounds

Science.gov (United States)

Lewis, J. Windsor

1975-01-01

Deals with the critique of Hans G. Hoffmann saying that the new phonetic symbols contained in A. S. Hornby's "Advanced Learner's Dictionary" (Oxford University Press, London, 1974) are harder to learn than the older system of transcription. (IFS/WGA)

Ka luule võib olla tantsitav / Aija Sakova

Index Scriptorium Estoniae

Sakova, Aija, 1980-

2005-01-01

21. ja 23. mail esinevad Tallinnas ja Tartus saksa, ameerika, prantsuse ja eesti luuletajad spoken word-kirjandusüritustega "Poesie united". Osalevad Wehwalt Koslovsky, Tobias Hoffmann, Milo Martin, Ben Porter Lewis, Antoine Faure, Jürgen Rooste, Asko Künnap ja fs

Nazad v budushtsheje / Jaroslava Tshudnovskaja

Index Scriptorium Estoniae

Tšudnovskaja, Jaroslava

2004-01-01

Dolores Hoffmann vitraažikunsti ajaloost, vitraažikoja asutamisest ja tegevusest Katariina käigus Tallinnas, vitraažimeistrite Boris Morejevi ja Aleksei tööst. vitraažikunstnik Dolores Hoffmanni lühibiograafia, tema tööd

Simunas pühitseti uus vitraažaken / Eva Klaas

Index Scriptorium Estoniae

Klaas, Eva, 1977-

2009-01-01

Simunas tähistati 31. oktoobril Simuna kiriku ja kogu kihelkonna nimepäeva, pühitseti ka äsjavalminud vitraažaken, mille autor on Dolores Hoffmann, kelle kujundatud on ka sarja "Maailma loomine" kuuluvad teised vitraažid

Kas "Medium is the message?" / Riin Kübarsepp

Index Scriptorium Estoniae

Kübarsepp, Riin, 1978-

2005-01-01

Eesti Päevalehe 100. sünnipäevale pühendatud rändnäitusest "Ajaleht kunstis" Rakvere Linnagaleriis. Eksponeeritakse Oskar Hoffmann, Jaan Elkeni, Raul Rajangu, Agur Kruusingu, Endel Kõksi, Valeri Vinogradovi, Jüri Ojaveri jt töid

Did goethe describe attention deficit hyperactivity disorder?

Science.gov (United States)

Bonazza, Sara; Scaglione, Cesa; Poppi, Massimo; Rizzo, Giovanni

2011-01-01

As early as 1846, the typical symptoms of attention deficit hyperactivity disorder (ADHD) were described by Heinrich Hoffmann (1809-1894). However, in Goethe's masterpiece Faust (1832), the character of Euphorion strongly suggests ADHD diagnosis. Copyright © 2011 S. Karger AG, Basel.

Proton Transfers at the Air-Water Interface

Science.gov (United States)

Mishra, Himanshu

molecular scale. Our results unambiguously demonstrated the role of electrostatic-reorganization of interfacial water during proton transfer events. With our experimental and theoretical results on the 'superacidity' of the surface of mildly acidic water, we also explored implications on atmospheric chemistry and green chemistry. Our most recent results explained the basis for the negative charge of the air-water interface and showed that the water-hydrophobe interface could serve as a site for enhanced autodissociation of water compared to the condensed phase. In a nutshell, this thesis presents an in-depth account of complementary experiments and theory employed to answer the questions listed above. It is primarily based on the following articles: 1. H. Mishra, S. Enami, L. A. Stewart, R. J. Nielsen, M. R. Hoffmann, W. A. Goddard III, A. J. Colussi, Proceedings of the National Academy of Sciences (2012), 109(46), 18679--18683; 2. H. Mishra, S. Enami, R. J. Nielsen, W. A. Goddard III, M.R. Hoffmann, A. J. Colussi, Proceedings of the National Academy of Sciences (2012), 109(26), 10228--10232; 3. H. Mishra, R. J. Nielsen, S. Enami, M. R. Hoffmann, A. J. Colussi, W. A. Goddard III, International Journal of Quantum Chemistry (2013), 113(4), 413--417; 4. S. Enami, H. Mishra, M. R. Hoffmann, A. J. Colussi, Journal of Physical Chemistry A (2012), 116 (24), 6027--6032. On the recommendation of the thesis committee, Appendix I and II have been added based on the following articles: S. Enami, H. Mishra, M. R. Hoffmann, A. J. Colussi, Journal of Chemical Physics (2012) 136(15), 154707, 1-7, and H. Mishra, C. J. Yu, D. P. Chen, W. A. Goddard, N. F. Dalleska, M. R. Hoffmann, M. S. Diallo, Environmental Science & Technology, (2012) 46(16), 8998-9004.

Taastatud Pilistvere pastoraat / Dolores Hoffmann, Helmi Seil, Vello Rajangu

Index Scriptorium Estoniae

Hoffmann, Dolores, 1937-

2006-01-01

7 ill.; fotod: Tiit Koha; kontoriruumi akent ehib Dagmar ?(Dolores) Hoffmanni vitraaž, seinal on Helmi Seili ristpistes tikitud Eesti kaart, talvekirikus Vello Rajangu Pallase päevil loodud inglikuju

Eesti tooraine: ebakvaliteetne või ülehinnatud? / Martin Hoffmann

Index Scriptorium Estoniae

Hoffmann, Martin

2010-01-01

Eesti müüdava liha, kala, köögivilja päritolust, kodumaise toodangu kvaliteedist. Asjatundjate hinnangul on Eestis küll väga head liha ja juurvilja, kuid nende kvaliteet kõigub ja tarnestabiilsus on halb. LM Keskuse müügijuhi Helgor Markovi, Horeca Sevice'i juhatuse liikme Raul Vaeti ja restoran Gloria peakoka Dmitri Demjanovi arvamusi ja hinnanguid

Evangelskije sjuzhetõ ljuterianskogo sobora / Jevgeni Ashihmin

Index Scriptorium Estoniae

Ashihmin, Jevgeni

2004-01-01

Narva Aleksandri Suurkirik saab 120. aastapäevaks värvilised vitraažid. Esimese vitraaži "Neitsi Maria" taastas Dolores Hoffmann, pärnapuust raam tehti mööblivabrikus Narova. Dolores Hoffmannil valmivad kiriku jaoks veel seitse vitraaži

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 12. A Tale of Two Topologies: Woodward-Hoffmann Rules At Your Fingertips! Subramania Ranganathan. Volume 16 Issue 12 December 2011 pp 1211-1222. Fulltext. Click here to view fulltext PDF. Permanent link:

Intergovernmentalisms: Gendering the Dinosaur?

NARCIS (Netherlands)

Vleuten, J.M. van der; Abels, G.; MacRae, H.

2016-01-01

Intergovernmentalism, whether in its original version (Hoffmann) or the liberal (Moravcsik) one, is usually portrayed as one of two classic, competing integration theories (the other one being neofunctionalism). It is also considered to be hopelessly limited as regards its explanatory power, due to

Sélection d'un champignon filamenteux pour l'épuration des eaux ...

African Journals Online (AJOL)

Sci-Nat

A quantum mechanical/ molecular mechanical study of the hydroxylation of phenol and halogenated derivatives by phenol hydroxylase. J. Am. Chem. Soc. 122, 8728-8738. Vankova S., Reznickova I., & Hoffmann J., 2000. Respirometric observation of inhibitory effects of xenobiotics on aerobic respiration of activated sludge ...

Gait variability and motor control in people with knee osteoarthritis

DEFF Research Database (Denmark)

Alkjaer, Tine; Raffalt, Peter C; Dalsgaard, Helle

2015-01-01

fluctuation analysis. The motor control was assessed by the soleus (SO) Hoffmann (H)-reflex modulation and muscle co-activation during walking. The results showed no statistically significant mean group differences in any of the gait variability measures or muscle co-activation levels. The SO H...

A Uniform Approach to Type Theory

Science.gov (United States)

1989-01-01

logical and statistical techniques. There is no comprehensive survey on implementation issues. Some partial aspects are described in...U. de Paris (1930). In: Ecrits logiques de Jacques Herbrand, PUF Paris (1968). [71] C. M. Hoffmann, M. J. O’Donnell. "Programming with Equations

["Kuhu me siis läheme? - Eks ikka koju."] / M. J.

Index Scriptorium Estoniae

Jõgi, Mall, 1947-

2016-01-01

Tutvustus: „Kuhu me siis läheme? - Eks ikka koju.“ : sajandivahetus saksa kirjanduses 200 aastat tagasi : Goethe, Schiller, Tieck, Kleist, Hoffmann, Eichendorff, Büchner, Novalis, Hegel (Schelling? Hölderlin?), Schlegel / saksa keelest valinud ja tõlkinud Mati Sirkel. Tallinn : Eesti Keele Sihtasutus, 2015

Distinguishing Plasmodium falciparum treatment failures from re-infections by using polymerase chain reaction genotyping in a holoendemic area in northeastern Tanzania

DEFF Research Database (Denmark)

Magesa, S M; Mdira, K Y; Farnert, A

2001-01-01

susceptibility to a combination of sulfadoxine/pyrimethamine (Fansidar; F. Hoffmann La Roche, Basel, Switzerland). Blood samples were collected before treatment and on days 7, 14, or 28 post-treatment in 51 asymptomatic children, of which 26 could not clear parasitemia within seven days post-treatment. Among...

"Uus tants 9" - kirju ja elujõuline / Evelin Lagle, Leenu Nigu

Index Scriptorium Estoniae

Lagle, Evelin

2009-01-01

19.-21. märtsini Tallinna teatrites ja saalides toimunud üheksandast Eesti uue tantsu ülevaatefestivalist "Uus Tants 9". Tantsulavastustest "Sula jagu", "Kahe korruse rahvas", "Can't Get No / Satisfaction", "Lokaalis täna: Kann/Valkeapää", "Kass ennustab tulevikku inimesest paremini", "Hoffmann-Promenade"

Disease: H00129 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ings in Hunter disease: pathology and possible therapeutic effects reviewed. ... JOURNAL ... J Inherit Metab Dis 31:473-80 (2008) DOI:10.1007/s10545-008-0878-x ... ...532 OMIM: 309900 PMID:18618289 ... AUTHORS ... Al Sawaf S, Mayatepek E, Hoffmann B ... TITLE ... Neurological find

Correction to: Tocilizumab: A Review in Rheumatoid Arthritis.

Science.gov (United States)

Scott, Lesley J

2018-02-01

The article Tocilizumab: A Review in Rheumatoid Arthritis, written by Lesley J. Scott, was originally published Online First without open access. After publication in volume 77, issue 17, pages 1865-1879 F. Hoffmann-La Roche Ltd requested that the article be Open Choice to make the article an open access publication. Post-publication open access was funded by F. Hoffmann-La Roche Ltd. Further details may be found at http://www.medengine.com/Redeem/68FBF06068F81EA7 . The article is forthwith distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( http://creativecommons.org/licenses/by-nc/4.0/ ), which permits any noncommercial use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Bomen hebben wortels, mensen hebben benen, ideeën hebben vleugels: een introductie

NARCIS (Netherlands)

Leerssen, J.

2008-01-01

Trees have roots, people have legs, ideas have wings: an introduction Taking a philological field trip in 1837 by A.H. Hoffmann von Fallersleben as an example, this essay demonstrates how the rise of medievalism and national philology in the Netherlands was not a homegrown development, but a result

Santa Margarita Estuary Water Quality Monitoring Data

Science.gov (United States)

2018-02-01

calibrations were conducted before the survey using standard methods. The sensor and DGPS data were downloaded to a computer after the survey and time matched...Auer, R. P., Canale, and J. P, Hoffmann. 1982. “Ecological Studies and Mathematical Modeling of Cladophora in Lake Huron: 5. Model Development and

Svetonosnoje iskusstvo / Lev Livshits

Index Scriptorium Estoniae

Лившиц, Лев, 1924-2013

2003-01-01

Katariina käigust Tallinnas. vitraažitöökojast-galeriist Domini Canes, seal töötavatest vitraažikunstnikest Dolores Hoffmannist ja Andrei Lobanovist, nende töödest nii Eestis kui ka välismaal. Dolores Hoffmann räägib vitraažist

East African Medical Journal - Vol 87, No 8 (2010)

African Journals Online (AJOL)

Association of the ENPP1 rs997509 polymorphism with obesity in South African mixed ancestry learners · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. T Matsha, B Fanampe, Y Yako, S Hassan, M Hoffmann, L Van der Merwe, RT Erasmus ...

Show and Tell

DEFF Research Database (Denmark)

2013-01-01

/DK), Pernille With Madsen, Emil Alenius, Andrés Galeano (E/DE), Kasper Vang & Mads Forsby, Nanna Lysholt Hansen og Molly & Me (Molly Haslund & Catherine Hoffmann (UK)) Kurateret af Judith Schwarzbart og Sanne Krogh Groth Produceret af studerende ved Performance-design Programmet var støttet af Statens Kunstråd...

A revision of the Paronychiinae

NARCIS (Netherlands)

Chaudhri, Mohammad Nazeer

1968-01-01

This study was undertaken, in April 1964, at the suggestion of Prof. Dr. J. Lanjouw. The need for such a revision, was, however, stressed by the authors of the subtribe, viz. PAX et K. HOFFMANN, who, while delimiting these genera, remarked that the Systematics of both the (main) genera of this

International Conference on Numerical Grid Generation in Computational Fluid Dynamics

Science.gov (United States)

1989-04-30

Joseph M. Juarez DFVLR SM -TS The Aerospace Corp. Bunsenstr-10 PO Box 92957 M5/559 D-3406 Gottingen Los Angeles CA 90009 F R Germany Klaus A. Hoffmann...Washington, D.C. 20332 Troy, NY 12180 Per Nielsen R. Raghunath Graduate Student Research Fellow Laboratory for Applied Math. Physic NOAA / AOML

VeriML: A Dependently-Typed, User-Extensible and Language-Centric Approach to Proof Assistants

Science.gov (United States)

2013-01-01

newly-arrived members of the FLINT group, especially Xinyu Feng, Alex Vaynberg, Rodrigo Ferreira, David Costanzo, Shu-Chun Weng, Jan Hoffmann and Mike...Constable, S.F. Allen, H.M. Bromley, W.R. Cleaveland, J.F. Cremer , R.W. Harper, D.J. Howe, T.B. Knoblock, N.P. Mendler, P. Panangaden, et al. Implementing

Assessing Physiological Response to Toxic Industrial Chemical Exposure in Megacities

Science.gov (United States)

2016-03-15

Prediction of Aristolochic Acid–Induced Renal Injury in Male Rats. Veterinary Pathology Online, 51(3), 680–694. http://doi.org/10.1177/0300985813498779... Microbiology , 52(6), 2039–2045. http://doi.org/10.1128/JCM.00467-14 24. Hoffmann, D., Adler, M., Vaidya, V., Rached, E., Mulrane, L., Gallagher, W. M

At the Very Root of the Development of Interest: Using Human Body Contexts to Improve Women's Emotional Engagement in Introductory Physics

Science.gov (United States)

Allaire-Duquette, Geneviève; Charland, Patrick; Riopel, Martin

2014-01-01

In physics, women find contexts concerning human biology, medical applications, or natural phenomena highly relevant (Hoffmann, 2002), and the rareness or absence of these in physics curricula may make it more difficult for women to develop and maintain their interest in physics. To date, research in physics education addressing student's…

Neue Lautzeichen im Advanced Learners Dictionary (ALD). Stellungnahmen zum Pro und Kontra (New Sound Symbols in the Advanced Learners Dictionary [ALD]. Considerations Pro and Con)

Science.gov (United States)

Zielsprache Englisch, 1976

1976-01-01

The phonetic symbols in the "Advanced Learners Dictionary" (Oxford University Press, London) are discussed critically in articles by L. Alfes, H. Arndt, E. Bauch, G. Dahlmann-Resing, W. Friedrich, E. Germer, B. Haycraft, H. P. Kelz. Reference is made to an earlier article "Neue Zeichen", by H. G. Hoffmann. (Text is in German.)…

Early application of tail nerve electrical stimulation-induced walking training promotes locomotor recovery in rats with spinal cord injury.

Science.gov (United States)

Zhang, S-X; Huang, F; Gates, M; Shen, X; Holmberg, E G

2016-11-01

This is a randomized controlled prospective trial with two parallel groups. The objective of this study was to determine whether early application of tail nerve electrical stimulation (TANES)-induced walking training can improve the locomotor function. This study was conducted in SCS Research Center in Colorado, USA. A contusion injury to spinal cord T10 was produced using the New York University impactor device with a 25 -mm height setting in female, adult Long-Evans rats. Injured rats were randomly divided into two groups (n=12 per group). One group was subjected to TANES-induced walking training 2 weeks post injury, and the other group, as control, received no TANES-induced walking training. Restorations of behavior and conduction were assessed using the Basso, Beattie and Bresnahan open-field rating scale, horizontal ladder rung walking test and electrophysiological test (Hoffmann reflex). Early application of TANES-induced walking training significantly improved the recovery of locomotor function and benefited the restoration of Hoffmann reflex. TANES-induced walking training is a useful method to promote locomotor recovery in rats with spinal cord injury.

UV-induced mitotic co-segregation of genetic markers in Candida albicans: Evidence for linkage

International Nuclear Information System (INIS)

Crandall, M.

1983-01-01

Parasexual genetic studies of the medically important yeast Candida albicans were performed using the method of UV-induced mitotic segregation. UV-irradiation of the Hoffmann-La Roche type culture of C. albicans yielded a limited spectrum of mutants at a relatively high fequency. This observation suggested natural heterozygosity. Canavanine-sensitive (CanS) segregants were induced at a frequency of 7.6 . 10 -3 . Double mutants that were both CanS and methionine (Met - ) auxotrophs were induced at a frequency of 7.4 . 10 -3 . The single Met - segregant class was missing indicating linkage. UV-induced CanS or Met - CanS segregants occurred occasionally in twin-sectored colonies. Analyses of the sectors as well as the observed and missing classes of segregants indicated that genes met and can are linked in the cis configuration. The proposed gene order is: centromere - met - can. Thus, it is concluded that the Hoffmann-La Roche strain of C. albicans is naturally heterozygous at two linked loci. These findings are consistent with diploidy. (orig.)

Grazing incidence polarized neutron scattering in reflection ...

Indian Academy of Sciences (India)

journal of. January 2012 physics pp. 1–58. Grazing incidence polarized ..... atomic distances, the neutron has an energy which is low compared to molecular binding ...... cores and that of the Co ions in the AF oxide coatings. ...... [32] C Leighton, M R Fitzsimmons, P Yashar, A Hoffmann, J Nogus, J Dura, C F Majkrzak and.

Mr Nissim Dahan, MK, Minister of Health, Israel, at the ATLAS exhibition

CERN Multimedia

Laurent Guiraud

2001-01-01

Photo 01: L. to r.:Dr Jim Allaby, Dr Peter Jenni, Prof. Bracha Regev, Chief Scientist, Ministry of Health, Mr Nissim Dahan, MK, Minister of Health, Dr Boaz Lev, Director General, Ministry of Health, Dr Hans F. Hoffmann and Dr Georges Mikenberg. Photo 02: Mr Nissim Dahan, MK, Minister of Health, Israel, signing the Guest Book.

Untitled

African Journals Online (AJOL)

Elamin

Krüger B, Fischereder M, Jauch KW, Graeb C,. Hoffmann U, Böger CA, Banas B, Obed A. Schlitt HJ,. Krämer BK. Five-year follow-up after late conversion from calcineurin inhibitors to sirolimus in patients with chronic renal allograff dysfunction. Transplant Proc. 2007 Mar,39(2):518-21. 54. Schena FP, Pascoe MD, Albertu J, ...

Organic Molecules and Water in the Inner Disks of T Tauri Stars

Science.gov (United States)

2011-05-11

603 Knez, C., et al. 2007, BAAS , 211, 5005 Kruger, A. J., Richter, M. J., Carr, J. S., Najita, J. R., Doppmann, G. W., & Seifahrt, A. 2011, ApJ, 729...Close, L. M., Hinz, P. M., Hoffmann, W. F., Greene, T. P., Males, J. R., & Beck , T. L. 2010, ApJ, 711, 1280 Tappe, A., Lada, C. J., Black, J. H

African Journal of Science and Technology (AJST) EFFETS DE L ...

African Journals Online (AJOL)

opiyo

glycosides et des chalcones (Hoffmann et Holzi, 1989), des terpènes et des huiles essentielles (Amvam Zollo et al.,1995), des composés acétyléniques et des flavonoïdes .... plants of tropical central Africa. XX : The occurrence of 1- phenyl-1,3,5- triyne in the essential oil of Bidens pilosa L. from Cameroun. Flavour and ...

Kumb oli agressor Hitler või Stalin / Rudolf Augstein

Index Scriptorium Estoniae

Augstein, Rudolf

1996-01-01

Järg Apr/13.,15.16.,17.,18.,19,20.,22.,23.,24.,25.,26. lk. 35,23,23,23,23,23,33,23,23,23,23,23. Kolme raamatu põhjal tehtud ülevaade sõjast: Vladimir Rezun "M-päev", Joachim Hoffmann "Stalini hävitussõda 1941-1945", Walter Post ""Barbarossa" plaan". Saksa ja Nõukogude kallaetungikavad 1940/41

[Establishing biological reference intervals of alanine transaminase for clinical laboratory stored database].

Science.gov (United States)

Guo, Wei; Song, Binbin; Shen, Junfei; Wu, Jiong; Zhang, Chunyan; Wang, Beili; Pan, Baishen

2015-08-25

To establish an indirect reference interval based on the test results of alanine aminotransferase stored in a laboratory information system. All alanine aminotransferase results were included for outpatients and physical examinations that were stored in the laboratory information system of Zhongshan Hospital during 2014. The original data were transformed using a Box-Cox transformation to obtain an approximate normal distribution. Outliers were identified and omitted using the Chauvenet and Tukey methods. The indirect reference intervals were obtained by simultaneously applying nonparametric and Hoffmann methods. The reference change value was selected to determine the statistical significance of the observed differences between the calculated and published reference intervals. The indirect reference intervals for alanine aminotransferase of all groups were 12 to 41 U/L (male, outpatient), 12 to 48 U/L (male, physical examination), 9 to 32 U/L (female, outpatient), and 8 to 35 U/L (female, physical examination), respectively. The absolute differences when compared with the direct results were all smaller than the reference change value of alanine aminotransferase. The Box-Cox transformation combined with the Hoffmann and Tukey methods is a simple and reliable technique that should be promoted and used by clinical laboratories.

Linnugripp tõi ravimifirmale Roche magusa kasumi / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2005-01-01

Šveitsi ravimitootja Roche'i viiruseravimi Tamiflu müük on kasvanud. Roche kavatseb järgmiseks suveks suurendada toodangut võrreldes 2004. aastaga kaheksa korda, kuid seda ei peeta piisavaks. ÜRO ja WHO nõuavad, et firma loobuks patentidest või annaks koopiaravimite valmistajatele tootmise litsentsi. Tabel: F. Hoffmann-La Roche. Lisa: Linnugripi vaktsiini võib loota kuue kuu pärast

The IMPACT Common Module - A Low Cost, Reconfigurable Building Block for Next Generation Phased Arrays

Science.gov (United States)

2016-03-31

Road NE Cedar Rapids, IA USA 52498 Ted.Hoffmann@corp.rockwellcollins.com Caleb Fulton, Mark Yeary, Austin Saunders, Dan Thompson University...thus providing increasing functionality and performance at reduced cost, size, and weight compared to their predecessors [ 4 -6]. This has been...Figure 4 ). The kickback would otherwise be very difficult to absorb by the ADC driver and would also cause ringing in the bond wire inductances

CMS Interim Memorandum of Understanding The Costs and How They are Calculated

CERN Document Server

Willers, Ian Malcolm

2001-01-01

This document explains how we arrived at the costs that are to be used in the Interim Memorandum of Understanding, iMoU. It integrates information taken from the Hoffmann review, PASTA and Lucas Taylor. I would like to thank Petr Moissenz for proof reading which helped me to improve the accuracy of the information in a short period of time. Also Claude Charlot for his valuable comments.

Effect of joint mobilization on the H Reflex amplitude in people with spasticity

OpenAIRE

Pérez Parra, Julio Ernesto; Henao Lema, Claudia Patricia

2011-01-01

Objective: To determine the effect of ankle joint mobilization on the H reflex amplitude of thesoleus muscle in people with spasticity. Materials and methods: A quasi-experimental study withcrossover design and simple masking was conducted in 24 randomized subjects to initiate thecontrol or experimental group. Traction and rhythmic oscillation were applied for five minutesto the ankle joint. H wave amplitude changes of Hoffmann reflex (electrical equivalent of themonosynaptic spinal reflex) w...

Visit of the Austrian Minister of Health and Women's Issues

CERN Multimedia

Maximilien Brice

2003-01-01

Mrs Maria Rauch-Kallat, Minister of Health and Women's Issues, Austria, came to CERN on 19 May. The theme of her visit was technology transfer. Photo 01: Dr Hans F. Hoffmann, CERN Director for Technology Transfer and Scientific Computing with Mrs Maria Rauch-Kallat, Minister of Health and Women's Issues, Austria, signing the VIP visitors' book. Photo 02: Mrs Maria Rauch-Kallat, Minister of Health and Women's Issues, Austria, signing the VIP visitors' book.

Lumbar paravertebral blockade as intractable pain management method in palliative care

OpenAIRE

Zaporowska-Stachowiak I; Kotlinska-Lemieszek A; Kowalski G; Kosicka K; Hoffmann K; Główka F; Łuczak J

2013-01-01

Iwona Zaporowska-Stachowiak,1,2 Aleksandra Kotlinska-Lemieszek,3 Grzegorz Kowalski,3 Katarzyna Kosicka,4 Karolina Hoffmann,5 Franciszek Główka,4 Jacek Łuczak2 1Department of Pharmacology, 2Palliative Medicine In-patient Unit, University Hospital of Lord’s Transfiguration, 3Department of Palliative Care, 4Department of Physical Pharmacy and Pharmacokinetics, 5Department of Internal Medicine, Metabolic Disorders and Arterial Hypertension, Poznan University of Medical Scie...

Dolores Hoffmann pani Türi kiriku aknad särama / Marge Laagemann

Index Scriptorium Estoniae

Laagemann, Marge

2005-01-01

vitraažikunstnik räägib Türi kiriku vitraažidest, oma teekonnast vitraažide juurde, vitraažide valmistamisest, nende tekkest, ajaloost ning mõjust. Järgneb 2005. 9. dets., lk. 9, 16. dets., lk. 7, 23. dets., lk. 11 ja 30. dets., lk. 7

[Christian Andreas Cothenius (1708-1789). A pro-memoria on the occasion of the 200th anniversary of his death].

Science.gov (United States)

Völker, A

1990-04-01

The 200th anniversary of the death of Christian Andreas Cothenius gave occasion to appreciate life and work of this personage of a physician. Cothenius maintained manifold connections to Halle, of which the golden doctorate and the heritage of the pharmaceutic enterprises of his teacher Friedrich Hoffmann were treated in this place. The picture of the local relations was supplemented by the history of the Cothenius medal which is today awarded by the Leopoldina of Halle.

Physical and Neuropsychiatric Trauma-Wound Healing and Tissue Preservation

Science.gov (United States)

2008-10-01

Neurosurg Spine 99:188-197. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514. Holtje M, Hoffmann A, Hofmann F, Mucke C...cytokines and receptors. Annu. Rev. Immunol. 22, 929–979 (2004). 21. S. J. Rodda, A. P. McMahon, Distinct roles for Hedgehog and canonical Wnt signaling in...Swain, M. S. Razzaque, S. Mackem, B. Lanske, Indian Hedgehog produced by postnatal chondrocytes is essen- tial for maintaining a growth plate and

Influence of an aerobic sediment-water interface in relation to reduced risk of phosphorus leaching from re-established wetlands

DEFF Research Database (Denmark)

Forsmann, Ditte M.; Kjærgaard, Charlotte

water interactions are of fundamental importance for the biogeochemical processes controlling phosphorus dynamics in wetlands, and different hydrological pathways such as groundwater discharge and surface water flooding are operating within wetlands (Hoffmann et al., 2009). During groundwater discharge...... depends both on the hydrological regimes and the processes taking place at the sediment-water interface. Re-oxidation of iron might allow a recapturing of phosphorus (Zak et al., 2004), and thereby impede P losses to the aquatic environment....

Music

OpenAIRE

Deinert, Herbert

2010-01-01

The musical ending [of Goethe's Novelle] recalls the fascination with "music as metaphor", "the power of music", among recent and contemporary poets from Pope and Dryden and Collins to E.T.A. Hoffmann and Kleist and, of course to Goethe himself. Music saves Faust's life on Easter morning at the end of a dreadful night, and we'll encounter a similar role of music in his Trilogie der Leidenschaft which we'll read in this context.

Belize it or not:implied contract terms in Marks and Spencer v BNP Paribas

OpenAIRE

McCunn, Joanna

2016-01-01

In Marks and Spencer v BNP Paribas, the Supreme Court restated the law on the implication of terms in fact, rejecting the previously authoritative approach taken by Lord Hoffmann in Attorney General of Belize v Belize Telecom Ltd. This article examines two major departures from Belize in Lord Neuberger’s leading judgment: the treatment of implication as a process separate from interpretation, and a return to the ‘traditional tests’ for the implication of terms. It argues that these are retrog...

The Genus Ixodes (Acari: Ixodidae) in Mexico: Adult Identification Keys, Diagnoses, Hosts, and Distribution

Science.gov (United States)

2010-01-01

Cricetidae and Hominidae ( Homo sapiens Linnaeus, 1758) (Mammalia) (Hoffmann, 1969). Note. The tick from Valle de Bravo, Estado de México, was...distribution El género Ixodes (Acari: Ixodidae) en México: claves de identifi cación para adultos, diagnosis, huéspedes y distribución Carmen Guzmán...Incorporación de Profesores de Carrera en Facultades y Escuelas para el Fortalecimiento de la Investigación (PROFIP). Tila María Pérez, Curator of CNAC

现实版“马达加斯加”德国上演

Institute of Scientific and Technical Information of China (English)

无

2012-01-01

A kangaroo is on the lam(在潜逃中)in Germany after breaking out of a wildlife park,with the help of a fox and a wild boar(野猪).Michael Hoffmann,assistant head of the Hochwildschutzpark,says the kangaroos got out of their cage after a young fox snuck into the park and dug a hole next to the cage’s fencing.Two of the three were then able to get out of the park entirely through

Perceived parenting and social support: can they predict academic achievement in Argentinean college students?

OpenAIRE

de la Iglesia, Guadalupe; Freiberg Hoffmann, Agustin; Fernández Liporace, Mercedes

2014-01-01

Guadalupe de la Iglesia,1,2 Agustin Freiberg Hoffmann,2 Mercedes Fernández Liporace1,2 1National Council of Scientific and Technical Research (CONICET), 2University of Buenos Aires, Buenos Aires, Argentina Abstract: The aim of this study was to test the ability to predict academic achievement through the perception of parenting and social support in a sample of 354 Argentinean college students. Their mean age was 23.50 years (standard deviation =2.62 years) and most of them (83.3%...

Česká literární moderna v časopise Aus fremden Zungen — čtyři příklady prostředkování // Czech literary modernism in the journal Aus fremden Zungen — four examples of mediation

Directory of Open Access Journals (Sweden)

Lucie Merhautová

2015-12-01

Full Text Available The study focuses on Bronislav Wellek, Adolph Donath, Camill Hoffmann, Oskar Wiener and Otto Hauser and their translations and articles on modern Czech literature published in the German journal Aus fremden Zungen (1891–1910. This fortnightly established by Joseph Kürschner dealt exclusively with foreign literature. Its openness to all kinds of literary currents and little-known minor literatures was unique within the system of German literary journals. A comparison indicates the key role played by mediators. The primary requirement for their activity was multilingualism, and it turns out that in the case of all the figures under consideration, language did not necessarily have the nationally symbolic significance ascribed by politics, and their identity basically did not depend on their use of one language or another. The progress and success of this mediation was not just decided by the literary standard of the translation, but all five translators were concerned to improve the standard of translation, as well as to change the approach to translation in general. The choice of text and its succeeded publication was determined by the involvement of the mediators in the Czech and German literary context. Hence Bronislav Wellek focused primarily on translations and interpretations of poetry by Jaroslav Vrchlický and J. S. Machar, whom he knew personally and who also introduced him to their own literary and intellectual circles. It was thanks to Vrchlický that he printed his translations in Eduard Albert’s anthologies Poesie aus Böhmen (1893–1895. Machar was responsible for other translations, e.g. Hilbert’s drama Vina, which Hermann Bahr was to help promote in the German-language sphere. Between 1896 and 1898, Adolph Donath attempted to build up his position as mediator between the Moderní revue circle and some representatives of Viennese modernism (e.g. Karl Kraus, Peter Altenberg and Felix Rappaport. For Aus fremden Zungen he

Studies on Colombian cryptogams XVIII. The genus Stereocaulon (Schreber) Hoffmann (Lichenès)

NARCIS (Netherlands)

Boekhout, T.

1982-01-01

Nineteen species of Stereocaulon are treated from the northern Andes, mainly from Colombia. Descriptions and keys are given, with notes on the north-Andean distribution and ecology. Seven species are new for the Colombian flora, viz. St. atlanticum, St. claviceps, St. corticatulum (chem. strain with

Lorentz covariant theory of gravitation

International Nuclear Information System (INIS)

Fagundes, H.V.

1974-12-01

An alternative method for the calculation of second order effects, like the secular shift of Mercury's perihelium is developed. This method uses the basic ideas of thirring combined with the more mathematical approach of Feyman. In the case of a static source, the treatment used is greatly simplified. Besides, Einstein-Infeld-Hoffmann's Lagrangian for a system of two particles and spin-orbit and spin-spin interactions of two particles with classical spin, ie, internal angular momentum in Moller's sense, are obtained from the Lorentz covariant theory

Prevalência de enteroparisitos na populaçao urbana de São Tomé - RN - estudo comparativo de um decênio

Directory of Open Access Journals (Sweden)

Carlos Alberto Moreira Campos

1982-12-01

Full Text Available Objetivando a obtenção de variáveis relacionadas aos fatores sócio-econômicos e sanitários no período de dez (10 anos, os autores colheram resultados sobre a prevalência de enteroparasitas na população urbana de São Tomé, Rio Grande do Norte, cujos dados foram coletados entre 09 a 27 de julho de 1979, empregando o método da sedimentação espontânea (Hoffmann, Pons e Janer, através de exames realizados em 826 amostras de fezes, com uma positividade de565 para as diversas parasitoses intestinais e correspondendo a uma prevalência de 68,4% em função das condições ambientais que, embora melhoradas, concorrem no processo de disseminação de helmintoses e protozooses, além de outras patologias.In view of socio-economic and sanitary changes during ten (10 years, the authors gathered data on the prevaíence of enteroparasites in the urban population of São Tomé, Rio Grande do Norte. They collected from July 9 to July 27, 1979, 826 faecal samples which they examined using the spontaneous sedimentation method (Hoffmann, Pons, and Janer. 565 were positive for the various intestinal parasites, corresponding to a prevaíence of 68,4%. Although environmetal conditions have improved, they still contributed to the dissemination intestinal protozoal and helminthic infections.

MOD-AGE - an algorithm for age-depth model construction; U-series dated speleothems case study

Science.gov (United States)

Hercman, H.; Pawlak, J.

2012-04-01

We present MOD-AGE - a new system for chronology construction. MOD-AGE can be used for profiles that have been dated by different methods. As input data, the system uses the following basic measurements: activities, atomic ratios or age, as well as depth measurement. Based on probability distributions describing the measurement results, MOD-AGE estimates the age~depth relation and its confidence bands. To avoid the use of difficult-to-meet assumptions, MOD-AGE uses nonparametric methods. We applied a Monte Carlo simulation to model age and depth values based on the real distribution of counted data (activities, atomic ratios, depths etc.). Several fitting methods could be applied for estimating the relationships; based on several tests, we decide to use LOESS method (locally weighted scatterplot smoothing). The stratigraphic correction procedure applied in the MOD-AGE program uses a probability calculus, which assumes that the ages of all the samples are correctly estimated. Information about the probability distribution of the samples' ages is used to estimate the most probable sequence that is concordant according to the superposition rule. MOD-AGE is presented as a tool for the chronology construction of speleothems that have been analyzed by the U-series method, and it is compared to the StalAge algorithm presented by D. Scholtz and D.L Hoffmann (2011). Scholtz, D., Hoffmann, D. L., 2011. StalAge - An algorithm designed for construction of speleothem age models. Quaternary Geochronology 6, 369-382.

[The dishonest, the ignorant and the insane artists--psychopathography and other paths to soul of the artist].

Science.gov (United States)

Høyersten, J G

2000-04-10

Psychopathography is a specific kind of biography focusing on psychological and psychopathological aspects of the personality and their significance for creative activity, especially in famous persons. Psychopathography evolved as a discipline from the 1830's onwards, as a product of psychiatry emerging as a science, reflecting its reductionist and nosological approach. An illustration of this method is the analysis of the author E.T.A. Hoffmann, a prototypical representative of the German romanticism at the beginning of the century. Hoffmann himself expresses, in allegorical terms, the menacing, irrational and unconscious domains of the human soul. Romanticism may be seen as a forerunner of the psychoanalytic movement. Confronted with modernism in art, pathographic considerations were to a large extent based upon the object of art itself, often with arrogant and repudiating conclusions concerning the artist. Classical psychoanalysis has had a marked tendency to deduce a great deal about the personality of the artist or the writer solely from analysis of a picture or written text. The pathographic approach of the first century of scientific psychiatry has had a renaissance over the last 15-20 years: The ever increasing interest in affective syndromes has entailed a tendency to trace and identify affective pathology in artists and writers, deceased or alive, often emphasizing the affective dynamics of the creative process, aspects also noted by the classical pathographers. More recent studies of the creative personality may also present improved instruments for the study of the creative process.

Exact solutions of Lovelock-Born-Infeld black holes

International Nuclear Information System (INIS)

Aiello, Matias; Ferraro, Rafael; Giribet, Gaston

2004-01-01

The exact five-dimensional charged black hole solution in Lovelock gravity coupled to Born-Infeld electrodynamics is presented. This solution interpolates between the Hoffmann black hole for the Einstein-Born-Infeld theory and other solutions in the Lovelock theory previously studied in the literature. It is shown how the conical singularity of the metric around the origin can be removed by a proper choice of the black hole parameters. The differences existing with the Reissner-Nordstroem black holes are discussed. In particular, we show the existence of charged black holes with a unique horizon

Bicontinuous liquid crystals

CERN Document Server

Lynch, Mathew L

2005-01-01

PrefaceIntroduction AcknowledgmentsBicontinuous Cubic Liquid Crystalline Materials: A Historical Perspective and Modern Assessment; Kr̄e LarssonIntermediate Phases; Michael C. Holmes and Marc S. LeaverCubic Phases and Human Skin: Theory and Practice; Steven Hoath and Lars NorlňThe Relationship between Bicontinuous Inverted Cubic Phases and Membrane Fusion; D.P. SiegelAspects of the Differential Geometry and Topology of Bicontinuous Liquid-Crystalline Phases; Robert W. CorkeryNovel L3 Phases and Their Macroscopic Properties; R. Beck and H. HoffmannBicontinuous Cubic Phases of Lipids with Entra

The Journal Microarrays

Directory of Open Access Journals (Sweden)

Shu-Kun Lin

2011-10-01

Full Text Available Our publishing company MDPI AG has its headquarters in Basel, Switzerland where there are thousands of scientists working in the laboratories of pharmaceutical companies and institutes including Novartis [1], F. Hoffmann-La Roche [2] and institutes affiliated with University of Basel [3]. In 1996, the first annual microplate conference MipTec was held in Basel, and the MipTec 2011 was held a few days ago in Basel [4]. I published a paper on microplate standardization presented at MipTec 1996 in MDPI’s longest-running journal Molecules [5-7]. [....

Relativity and its roots

CERN Document Server

Hoffmann, Banesh

1998-01-01

In this fascinating, accessible introduction to one of the most revolutionary developments in modern physics, Einstein scholar Banesh Hoffmann recounts the successive insights that led to both the special and general theories of relativity.Using simple examples from everyday life, the author presents entertaining, nontechnical demonstrations of what relativity actually means and how it has revolutionized our ideas of time and space. Starting with the geometrical and cosmological ideas of the ancient Greeks, the author traces the succession of ideas and advances that paved the way for modern p

Gravitational Lagrangians, Mach's Principle, and the Equivalence Principle in an Expanding Universe

Science.gov (United States)

Essén, Hanno

2014-08-01

Gravitational Lagrangians as derived by Fock for the Einstein-Infeld-Hoffmann approach, and by Kennedy assuming only a fourth rank tensor interaction, contain long range interactions. Here we investigate how these affect the local dynamics when integrated over an expanding universe out to the Hubble radius. Taking the cosmic expansion velocity into account in a heuristic manner it is found that these long range interactions imply Mach's principle, provided the universe has the critical density, and that mass is renormalized. Suitable higher order additions to the Lagrangians make the formalism consistent with the equivalence principle.

Relações Internacionais no Brasil: a expansão dos manuais*

Directory of Open Access Journals (Sweden)

ROGÉRIO DE SOUZA FARIAS

2011-01-01

Full Text Available Resenha de BAUMANN, Renato, CANUTO, Otaviano, et al. Economia internacional: teoria e experiência brasileira. Rio de Janeiro: Elsevier. 2004. 442 p. ISBN: 85-353-1441-0. HERZ, Mônica e HOFFMANN, Andrea Ribeiro. Organizações internacionais: história e práticas. Rio de Janeiro: Elsevier, 2004. 268 p. ISBN: 85-352-1453-4. NOGUEIRA, João Pontes e MESSARI, Nizar. Teoria das relações internacionais: correntes e debates. Rio de Janeiro: Elsevier, 2005. 250 p. 85-352- 1687-1.

Members of the State Council of Geneva

CERN Multimedia

Maximilien Brice

2002-01-01

Luncheon hosted by the Director-General for members of the State Council of Geneva: From left to right A. Naudi; J. May; M. Carlo Lamprecht, State Council - Employement, Foreign Office and Economic Departement; M. Robert Hensler, State Chancellor; L. Maiani, CERN Director General; H.F. Hoffmann; M. Robert Cramer, State Council - Environment, Agriculture and Interior Departement; J.Van Der Boon; M. Laurent Moutinot, State Council - Installation, equipment and housing Departement; C. Détraz; C. Wyss; P. Jenni; G. Hentsch; M. Pierre-François Unger, State Council - Health and Social Action Departement; G. Stassinakis; M. Bourquin, CERN Council President.

The Wolf-Rayet eclipsing binary HD 5980 in the Small Magellanic Cloud

International Nuclear Information System (INIS)

Breysacher, J.; Moffat, A.F.J.

1982-01-01

The Wolf-Rayet star HD 5980, which is probably associated with the bright HII region NGC 346 of the Small Magellanic Cloud, was found to be an eclipsing binary by Hoffmann, Stift and Moffat (1978). Breysacher and Perrier (1980) determined the orbital period, P=19.26 +- 0.003d, of the system whose light curve reveals a strongly eccentric orbit (e=0.47 for i=80 0 ). The behaviour of the light curve outside the eclipses shows that one is dealing with a rather complex binary system. An analysis of the spectroscopic data is presented here. (Auth.)

A Short Discussion of Crisis Management – Practical Experience with the 2006 Electoral Campaign in the Czech Republic

Directory of Open Access Journals (Sweden)

Tomáš Zdechovský

2007-08-01

Full Text Available The rival candidate – directly or through a “third person” – attacks, parodies or mocks the rival and his or her services, trying to persuade voters of the exclusivity of his or her own products. Negative campaigns fabricate situations which have not occurred, pointing out the weaknesses of the rival and trying to draw voters’ attention to them. During the Senate campaign in autumn 2006 for constituency No. 44, Chrudim, Petr Pithart had to face repeated media attacks (in Chrudimský deník by Chrudim businessman Ivan Hoffmann. What can be learned from Pithart’s defense.

Tables of range and rate of energy loss of charged particles of energy 0,5 to 150 MeV

Energy Technology Data Exchange (ETDEWEB)

Williamson, C; Boujot, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

The accurate knowledge of ranges and rates of energy loss of charged particles is very important for physicists working with nuclear accelerators. The tabulations of Aron, Hoffmann, and Williams and later of Madey and Rich have proved extremely useful. However, recent experimental range measurements have indicated the need for a new tabulation of the range-energy relation. It was felt that a useful purpose would be served by performing the calculations for a large number of stopping materials distributed throughout the periodic table, including the materials most commonly used as targets, detectors, and entrance foils. (authors)

Die Kritik am romantischen Ideal in E. T. A. Hoffmanns «Der goldene Topf»

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Jasmin Marjam Rezai Dubiel

2013-11-01

Full Text Available E. T. A. Hoffmann’s Der Goldene Topf portrays fantasy and the ideal of romantic aestheticism as utopian on a metafictional level. However, another possibility should be considered: the temporary contemplation within poetry compensates for the loss of belief in the poeticization of the world as conceived by Novalis. The artistic entity cannot immerse itself in the romantic ideal. Since the narrator becomes part of the story and a victim of his imagination, the narration presents a critical viewpoint of the concept of genius.

Reflexive contraction of the levator palpebrae superioris muscle to involuntarily sustain the effective eyelid retraction through the transverse trigeminal proprioceptive nerve on the proximal Mueller's muscle: verification with evoked electromyography.

Science.gov (United States)

Ban, Ryokuya; Matsuo, Kiyoshi; Osada, Yoshiro; Ban, Midori; Yuzuriha, Shunsuke

2010-01-01

We have proposed a hypothetical mechanism to involuntarily sustain the effective eyelid retraction, which consists of not only voluntary but also reflexive contractions of the levator palpebrae superior muscle (LPSM). Voluntary contraction of fast-twitch fibres of the LPSM stretches the mechanoreceptors in Mueller's muscle to evoke trigeminal proprioception, which induces continuous reflexive contraction of slow-twitch fibres of the LPSM through the trigeminal proprioceptive nerve fibres innervating the mechanoreceptors in Mueller's muscle via the oculomotor neurons, as a tonic trigemino-oculomotor reflex. In the common skeletal mixed muscles, electrical stimulation of the proprioceptive nerve, which apparently connects the mechanoreceptors in muscle spindles to the motoneurons, induces the electromyographic response as the Hoffmann reflex. To verify the presence of the trigemino-oculomotor reflex, we confirmed whether intra-operative electrical simulation of the transverse trigeminal proprioceptive nerve on the proximal Mueller's muscle evokes an electromyographic response in the LPSM under general anaesthesia in 12 patients. An ipsilateral, phasic, short-latency response (latency: 2.8+/-0.3 ms) was induced in the ipsilateral LPSM in 10 of 12 subjects. As successful induction of the short-latency response in the ipsilateral LPSM corresponds to the Hoffmann reflex in the common skeletal mixed muscles, the present study is the first electromyographic verification of the presence of the monosynaptic trigemino-oculomotor reflex to induce reflexive contraction of the LPSM. The presence of the trigemino-oculomotor reflex may elucidate the unexplainable blepharoptosis due to surgery, trauma and tumour, all of which may damage the trigeminal proprioceptive nerve fibres to impair the trigemino-oculomotor reflex. Copyright (c) 2008. Published by Elsevier Ltd.

JST Thesaurus Headwords and Synonyms: Woodward‐Hoffmann則 [MeCab user dictionary for science technology term[Archive

Lifescience Database Archive (English)

Full Text Available MeCab user dictionary for science technology term Woodward‐Hoffmann則 名詞 一般 * * * * ...Ｗｏｏｄｗａｒｄ‐Ｈｏｆｆｍａｎｎ則 Ｗｏｏｄｗａｒｄ‐Ｈｏｆｆｍａｎｎソク ダブリューオーオーディーダブリューエイアールディー‐エイチオーエフエフエムエイエヌエヌソク Thesaurus2015 200906012584096939 C CA22 UNKNOWN_2 Woodward ‐ Hoffmann 則

A Study of Electrocyclic Reactions in a Molecular Junction

DEFF Research Database (Denmark)

Olsen, Stine Tetzschner; Nielsen, Mogens Brøndsted; Hansen, Thorsten

2017-01-01

must be in accordance to the orbital symmetry rules expressed by the Woodward-Hoffmann rules (when the electrodes do not significantly alter the molecular orbital appearances). We find these two requirements to be valid for the dianion of (1E,3Z,5E)-hexa-1,3,5-triene-1,6-diamine, and the Coulomb...... blockade diamonds were therefore modeled for this compound to elucidate how a dark photoswitching event would manifest itself in the stability plot. From this modeling of conductance as a function of gate and bias potentials, we predict a collapse in Coulomb diamond size, that is, a decrease in the height...

Geneva University honours two CERN staff members

CERN Multimedia

2001-01-01

Albert Hofmann Steve Myers On 8 June, two CERN staff members will receive Geneva University's highest distinction. On the proposal of the University's particle physicists, Steve Myers and Albert Hoffmann, who orchestrated LEP commissioning and operation and were instrumental in its success, will awarded the distinction of doctor honoris causa. The ceremony, interspersed with musical interludes, will be followed by a formal reception and is open to all. The Uni Dufour car park will be free to members of the public attending the ceremony. 8 June 2001 at 10.00 a.m. Uni Dufour, Auditoire Piaget 24, rue Général Dufour, Geneva.

Freqüência de parasitas intestinais em felinos mantidos em zoológicos Frequency of intestinal parasites in felines kept in zoos

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G.C.K. Müller

2005-08-01

Full Text Available The endoparasites occurrence in felines confined in two Zoos, between December 1999 and April 2000, was studied. Fecal samples of 18 felines (Panthera tigris, Panthera leo, Felis serval, Panthera onca, Puma concolor, Leopardus tigrinus and Leopardus wiedii were collected and the methods of Faust, modified Baermann and Hoffmann, were used for fecal analyses. Three genera were identified in the feces: Trichuris spp., Toxocara spp. and Giardia spp. In the zoo of Pomerode, six animals (46% were infected by Trichuris spp. and/or Giardia spp. and all samples from the zoo of Brusque were infected by Trichuris spp., Toxocara spp. and Giardia spp.

Die Stadt. Passagen zwischen Literatur und Architektur

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Wolfgang Bongers

2003-12-01

Full Text Available O artigo pretende contribuir para uma arqueologia literária da cidade. Autores como Hoffmann, Poe e Baudelaire reagiram desde o começo da modernidade com novas perspectivas às ondas de modernização e construiram modelos de observação da metrópole européia, capazes de estabelecer novos discursos. Eles encontram sua continuação e transformação nas literaturas latinoamericana (Borges, cortázar, Marechal, Piglia e europeia (Aragon, Benjamin, Borchert, Brecht, Calvino, Döblin. Os textos apresentam, todavia, cidades imperceptíveis e invisíveis, que indicam as mudanças das arquiteturas urbanas.

Multiparticle dynamics in an expanding universe

Science.gov (United States)

Anderson, James L.

1995-11-01

Approximate equations of motion for multiparticle systems in an expanding Einstein-deSitter universe are derived from the Einstein-Maxwell field equations using the Einstein-Infeld-Hoffmann surface integral method. At the Newtonian level of approximation one finds that, in comoving coordinates, both the Newtonian gravitational and Coulomb interactions in these equations are multiplied by the inverse third power of the scale factor R(t) appearing in the Einstein-deSitter field and they acquire a cosmic ``drag'' term. Nevertheless, both the period and luminosity size of bound two-body systems whose period is small compared to the Hubble time are found to be independent of t.

ELEVATE: an innovative study design to assess the efficacy, safety, and evolution of cardiovascular parameters in de novo kidney transplant recipients after early conversion from a calcineurin inhibitor to everolimus

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van der Giet M

2014-03-01

Full Text Available Markus van der Giet,1 Josep M Cruzado,2 Johan W de Fijter,3 Hallvard Holdaas,4 Zailong Wang,5 Antonio Speziale,6 Guido Junge61Department of Nephrology, Campus Benjamin Franklin, Charite'-Universitätsmedizin, Berlin, Germany; 2Department of Nephrology, University Hospital of Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; 3Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands; 4Section of Nephrology, Department of Transplant Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; 5Biometrics and Statistical Science, Novartis Pharmaceuticals, East Hanover, NJ, USA; 6Research and Development, Novartis Pharma AG, Basel, SwitzerlandAbstract: Progressive decline in allograft function and cardiovascular mortality after kidney transplantation remain major clinical challenges that can potentially be addressed by the mammalian target of rapamycin (mTOR inhibitors, everolimus and sirolimus. mTOR inhibitors maintain immunosuppressive efficacy after minimization of calcineurin inhibitor (CNI therapy and can achieve significant long-term improvements in renal function. Recently, data have accumulated that suggest mTOR inhibitors may offer cardioprotective effects. In animal models, inhibition of mTOR leads to regression of cardiac hypertrophy, and the limited data consistently point to a remodeling benefit following heart transplantation. Experimentally, mTOR inhibitors restrict atherogenesis, confirmed clinically by intravascular ultrasound data demonstrating lower rates of transplant vasculopathy in heart transplant recipients on everolimus. Lastly, mTOR inhibitors appear to ameliorate arterial stiffness, a known risk factor for post-transplant cardiovascular events, but data remain sparse. The ELEVATE study will examine the renal effect of early conversion from CNI therapy to everolimus after kidney transplantation. Key secondary endpoints include the change in left ventricular mass index, the first time

Responses of diatom communities to hydrological processes during rainfall events

Science.gov (United States)

Wu, Naicheng; Faber, Claas; Ulrich, Uta; Fohrer, Nicola

2015-04-01

The importance of diatoms as a tracer of hydrological processes has been recently recognized (Pfister et al. 2009, Pfister et al. 2011, Tauro et al. 2013). However, diatom variations in a short-term scale (e.g., sub-daily) during rainfall events have not been well documented yet. In this study, rainfall event-based diatom samples were taken at the outlet of the Kielstau catchment (50 km2), a lowland catchment in northern Germany. A total of nine rainfall events were caught from May 2013 to April 2014. Non-metric multidimensional scaling (NMDS) revealed that diatom communities of different events were well separated along NMDS axis I and II, indicating a remarkable temporal variation. By correlating water level (a proxy of discharge) and different diatom indices, close relationships were found. For example, species richness, biovolume (μm3), Shannon diversity and moisture index01 (%, classified according to van Dam et al. 1994) were positively related with water level at the beginning phase of the rainfall (i.e. increasing limb of discharge peak). However, in contrast, during the recession limb of the discharge peak, diatom indices showed distinct responses to water level declines in different rainfall events. These preliminary results indicate that diatom indices are highly related to hydrological processes. The next steps will include finding out the possible mechanisms of the above phenomena, and exploring the contributions of abiotic variables (e.g., hydrologic indices, nutrients) to diatom community patterns. Based on this and ongoing studies (Wu et al. unpublished data), we will incorporate diatom data into End Member Mixing Analysis (EMMA) and select the tracer set that is best suited for separation of different runoff components in our study catchment. Keywords: Diatoms, Rainfall event, Non-metric multidimensional scaling, Hydrological process, Indices References: Pfister L, McDonnell JJ, Wrede S, Hlúbiková D, Matgen P, Fenicia F, Ector L, Hoffmann L

[Utilization of feed energy by growing pigs. 3. Energy requirement for the growth and fattening of pigs].

Science.gov (United States)

Hoffmann, L; Schiemann, R; Jentsch, W

1979-02-01

The test series for the investigation of the energy consumption of growing pigs of the breeds large white and improved land race pig as well as cross breeds of the two breeds in a total of 369 metabolism periods (as described in the first two pieces of information of this publication series -- Hoffmann and others, 1977 and Jentsch and Hoffmann, 1977) were statistically analysed for the purpose of the derivation of the energy requirement for maintenance and the partial energy requirement for growth in order to test the possibilities of the factorial analysis for the derivation of energy requirement values of growing pigs. The dependence of the maintenance requirement of growing pigs (investigations in the live weight range of 10 to 40 kg -- see 1st information--were made with boars those in the live weight range of 30 to 120 kg were made with gelded boars, 2nd information) on the live weight can best be characterised by applying a power exponent of 0,61 or 0,62 for the live weight. A definition is offered to be discussed for the energetic maintenance requirement of productive live stock and laboratory animals as a conventional value. The energy requirement values derived from the doubly-factorial statistical analysis show a satisfactory adaptation to the measured values as such concerning energy intake and observed growth performance of the test animals. The conclusion is drawn that the factorial analysis of the energy requirement (maintenance plus partial performances) results in a better estimate of the requirement of growing animals than the assessment according only to live weight and live weight increase without characterising the energy requirement for partial performances. This is important for the further working on and more exact definition of requirement norms.

Software development agreement between CERN and the Indian Department of Atomic Energy

CERN Multimedia

Patrice Loïez

2003-01-01

The development and prototyping work for the LHC computing facility is being organised as a project that includes many scientific institutes and industrial partners, coordinated by CERN. The project is nicknamed LCG (after LHC Computing Grid). Addendum No. 1 to the Protocol dated 24/09/02 to the 1991 co-operation agreement between CERN and the Department of Atomic Energy (DAE) of the Government of India defines the collaboration between CERN and DAE on software development for the LCG Prototype Project. Signing the addendum are G. Govindrajan (left), Director of the Electronics and Instrumentation Group at the Bhabha Atomic Research Centre, Mumbai, India and Dr. Hans Hoffmann, CERN Director for Technology Transfer and for Scientific Computing.

CARACTERIZACIÓN MORFOLÓGICA Y ANATÓMICA DEL GÉNERO STEREOCAULON HOFFMANN (ASCOMYCETES-LIQUENIZADOS EN COLOMBIA

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ANGÉLICA RINCÓN-ESPITIA

2013-12-01

Full Text Available El género Stereocaulon presenta una gran plasticidad en sus estructuras morfológicas y anatómicas, que de no ser reconocidas se puede recaer en errores taxonómicos a nivel intraespecífico. Por esta razón, se presenta una diferenciación morfoanatómica de los caracteres diagnósticos: los filocladios, los cefalodios y los soredios para facilitar el proceso de identificación taxonómica. En esta contribución se reconocen 19 especies junto con cinco variedades de Stereocaulon para Colombia, se amplían los datos de distribución geográfica y se incluye una clave taxonómica para la identificación de las especies en el país.

Characterization of grog of bricks; Caracterizacao de chamote de blocos de vedacao

Energy Technology Data Exchange (ETDEWEB)

Candido, V.S.; Pinheiro, R.M.; Monteiro, S.N.; Vieira, C.M.F. [Universidade Estadual do Norte Fluminense Darcy Ribeiro (LAMAV/CCT/UENF), Campos dos Goytacazes, RJ (Brazil). Lab. de Materiais Avancados

2010-07-01

This work aims to characterize a waste of red ceramic, grog, generated from the milling of defective pieces of bricks fired in a Hoffmann type furnace by a industry from Campos dos Goytacazes-RJ. The grog was tested for X-ray diffraction, X-ray fluorescence, thermogravimetric and differential thermal analysis, dilatometry, sieving and sedimentation by gravity and optical microscopy. The results indicated that the grog is predominantly constituted of quartz, muscovite mica and hematite. The presence of kaolinite indicates that the bricks were fired at low temperatures, below 600 deg C. Finally, the characterization results indicated that the grog presents itself as an alternative non plastic material to be used in mixtures with clays for the production of red ceramics. (author)

Characterization of grog of bricks

International Nuclear Information System (INIS)

Candido, V.S.; Pinheiro, R.M.; Monteiro, S.N.; Vieira, C.M.F.

2010-01-01

This work aims to characterize a waste of red ceramic, grog, generated from the milling of defective pieces of bricks fired in a Hoffmann type furnace by a industry from Campos dos Goytacazes-RJ. The grog was tested for X-ray diffraction, X-ray fluorescence, thermogravimetric and differential thermal analysis, dilatometry, sieving and sedimentation by gravity and optical microscopy. The results indicated that the grog is predominantly constituted of quartz, muscovite mica and hematite. The presence of kaolinite indicates that the bricks were fired at low temperatures, below 600 deg C. Finally, the characterization results indicated that the grog presents itself as an alternative non plastic material to be used in mixtures with clays for the production of red ceramics. (author)

Dr. Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran

CERN Multimedia

Patrice Loïez

2001-01-01

L. to. r.:Dr Henrik Foeth, Team Leader, CMS experiment; Dr Daniel Denegri, Physics Coordinator, CMS experiment; Prof. Tejinder Virdee, Deputy Spokesman, CMS experiment; Prof. Luciano Maiani, CERN Director-General (signing); Mr Jean-Marie Dufour, Head of the Legal Service, Mr Ghodratollah Habibpour Gharakol (back); Dr Abdolali Sharghi, Advisor to the Minister and Director General, Office of International Scientific Cooperation, Ministry of Science, Research and Technology; Dr Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran (signing); Dr Reza Mansouri, Director, International Scientific Meetings Office, Ministry of Science, Research and Technology; H. E. Dr Ali Khorram, Extraordinary and plenipotentiary Ambassador to the United Nations in Geneva and Dr Hans F. Hoffmann, CERN Director for Technology Transfer & for Scientific Computing. _

Cerambycidae (Coleoptera from Lagoa do Tamburí farm, Aracatu – Bahia, with new records

Directory of Open Access Journals (Sweden)

ANDRÉ DA SILVA FERREIRA

2015-01-01

Full Text Available ABSTRACTSpecies of Cerambycidae were inventoried in an area of Caatinga (dryland vegetation in the municipality of Aracatu, Bahia State, Brazil, between August/2012 and July/2013. The insects were collected using light traps, active searches, and white cloth trapping. A total of 716 specimens of Cerambycidae were collected; 665 of them were identified as belonging to 107 species, 84 genera, 30 tribes, and 3 subfamilies. The speciesPhaedinus carbonelli Monné, 1999,Lepturges (Lepturges fasciculatoides Gilmour, 1962,Hoplistonychus bondari Melzer, 1930,Ataxia arenaria Martins & Galileo, 2013 were new records for Bahia;Nesozineus obscurus Hoffmann, 1984 is new record for Brazil. The subfamily Cerambycinae demonstrated the greatest richness, with 56 species. These results contribute to our knowledge of the Cerambycidae fauna of Brazil.

Effect of Smokeless Tobacco on Surface Roughness of Dental Restorations

Science.gov (United States)

2016-05-01

peer pressure.  Ingredients  found in smokeless tobacco include:  polonium   210 , n­nitrosamines, formaldehyde,  nicotine, cadmium, cyanide, arsenic...flavors, preservatives, and sugars are also added.  Polynuclear aromatic  hydrocarbons,  polonium   210 , and n­nitrosamines represent the chemical...N­nitrosamines in tobacco by super critical fluid extraction. Journal of   Agricultural and  Food  Chemistry 43, 916–922.     24 Brunnemann KD, Hoffmann D, Qi J

Estudo piloto sobre esquistossomose mansoni em área rural do Município de Itanhomi, Vale do Rio Doce, Minas Gerais

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Maria José Conceição

1978-12-01

Full Text Available Neste trabalho os autores apresentam dados relativos à prevalência e formas clinicas da esquistossomose mansoni, hospedeiro intermediário e determinação do seu índice de infecção em Santa Luzia do Carneiro, área rural do Município de Itanhomi, Vale do Rio Doce, Minas Gerais. O estudo seccional da população revelou 42,1% de positividade para ovos de S.mansoni em um exame de fezes peto método de Lutz (Hoffmann, Ponz, Janer e um percentual de 6,8% de pacientes com hepato-esplenomegalia. O hospedeiro intermediário encontrado foi a B.glabrata com um índice de infecção de 3,2%.

Nissi Maarja kiriku kooriruumi kahe vitraažakna restaureerimine / H. Beyermann, Illar Kannelmäe, Dolores Hoffmann

Index Scriptorium Estoniae

Beyermann, H.

2005-01-01

4 ill.; aknad valmistas Riia meister H. Beyermann, ühel aknal on kujutatud evangelist Johannest, teisel apostel Peetrust; töid teostasid Dolores Hoffmanni juhendamisel OÜ Domini Canes meistrid B. Morejev, S. Ganin ja A. Bruk, kaitseklaaside projekti tegi Illar Kannelmäe

Il perturbante è l’identità divisa Un’interpretazione di Der Sandmann

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Giovanni Bottiroli

2015-07-01

Full Text Available Il saggio di Freud sul perturbante ha offerto molti stimoli agli studi letterari e a quelli sul cinema: è stato commentato e discusso molte volte. Nella maggior parte dei casi, tuttavia, sembra essere stato letto frettolosamente: ci si è soffermati sulla tesi più evidente, che stabilisce un nesso tra perturbante e angoscia di castrazione, e sono state trascurate le affermazioni relative al problema dell’identità. Eppure, proprio in relazione a Der Sandmann Freud offre riflessioni di straordinaria importanza. Questo articolo si propone anzitutto di restituire al saggio di Freud la sua complessità: vengono messi in luce, ad esempio, i fraintendimenti e le forzature della critica femminista (Sarah Kof- man. E, soprattutto, propone una nuova interpretazione del racconto di Hoffmann, a partire dal concetto di ‘identità divisa’. L’identità si dice in due modi fondamentali, la coincidenza e la non-coincidenza con se stessi. Ogni soggetto sperimenta il conflitto tra questi due modi. Nel racconto di Hoffmann, il prota- gonista (Nathaniel viene trascinato al di là di se stesso, verso la fatale coincidenza con das Ding. È questa la fonte essenziale della sua angoscia. Der Sandmann è la storia di un’attrazione inesora- bile, rallentata da entità che svolgono una funzione-schermo: nel rapporto con la bambola Olimpia emergono tutti i paradossi che determinano la fragile identità di Nathaniel. Poiché il perturbante appartiene al campo dell’angoscia, non sarebbe stato possibile ignorare il Seminario X di Lacan, così come le riflessioni di Heidegger. Quest’articolo propone una revisione della concezione di Lacan: l’angoscia più devastante non deriva tanto da un eccesso di presenza (ciò che Lacan chiama «la mancanza della mancanza» quanto dallo svanire della non- coincidenza. Perturbante è la sensazione di un collasso logico-ontologico, a causa del quale il soggetto viene come incellofanato in se stesso

Physical consequences of the interpretation of the skew part of gμν in Einstein's nonsymmetric unified field theory

International Nuclear Information System (INIS)

Voros, J.

1995-01-01

The electromagnetic interaction in the Einstein-Infeld-Hoffmann (EIH) equations of motion for charged particles in Einstein's unified field theory (EUFT) is found to be automatically precluded by the conventional identification of the skew part of the fundamental tensor with the Faraday tensor. It is shown that an alternative identification, suggested by observations of Einstein, Bergmann and Papapetrou, would lead to the expected electromagnetic interaction, were it not for the intervention of an infelicitous (radiation) gauge. Therefore, an EIH analysis of EUFT is inconclusive as a test of the physical viability of the theory, and it follows that EUFT cannot be considered necessarily unphysical on the basis of such an analysis. It is concluded that, historically, Einstein's unified field theory was rejected for the wrong reason. 26 refs

CERN in the park

CERN Multimedia

2002-01-01

CERN will be the centre of debate at a 'Café scientifique' on Monday 29 April. The aim of the Cafés scientifiques, which are organised by the association of Bancs Publics, is to kindle discussion between ordinary people and specialists in a scientific field. This Monday, Maurice Bourquin, President of the CERN Council, Hans Hoffmann, Director of Technology Transfer and Scientific Computing at CERN, Gilbert Guignard, a physicist at CERN, and Ruhal Floris, who teaches mathematical didactics at the University of Geneva, will explain the usefulness and contributions to science of the world's biggest laboratory for particle physics. What is CERN for? Monday 29 April at 18.30 Musée d'histoire des sciences, Geneva (in the park Perle du Lac) Entry free Wine and buffet after the discussion

A literatura e o cinema como novo medium artístico: Hanns Heinz Ewers e O estudante de Praga (1913

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Michael Korfmann

2008-11-01

Full Text Available The Student from Prague  (1913 is considered to be the first  film d’art produced in Germany. The film is based on a script by Ha nns Heinz Ewers, writer and ardent advocate of this new medium. With roots in German romantic ism, particularly in regard to motifs in the works by E.T.A. Hoffmann and Adelbert von Chamisso, The Student from Prague explored the optical possibilities offered by the doppelganger character. This literary framework supports the plot, gives credibility to the movie and contribut es to the acceptance of films as an art medium. It also marks the rise of German cinema on an international level, which reached its peak in the 1920s with the movement known as ‘German expressionism’. 

Case of asymmetrical arthrogryposis. A clinical study and a preliminary report on the value of CT-scanning

Energy Technology Data Exchange (ETDEWEB)

Hageman, G.; Vette, J.K.; Willemse, J. (University Hospital, Utrecht (Netherlands))

1983-01-01

Following the introduction of the conception that arthrogryposis is a symptom and not a clinical entity, a case of the very rare asymmetric form of neurogenic arthrogryposis is presented. The asymmetry of congenital contractures and weakness is associated with hemihypotrophy. The value of muscular CT-scanning prior to muscle biopsy is demonstrated. Muscular CT-scanning shows the extension of adipose tissue, which has replaced damaged muscles and therby indicates the exact site for muscle biopsy. Since orthopaedic treatment in arthrogryposis can be unrewarding due to severe muscular degeneration, preoperative scanning may provide additional important information on muscular function and thus be of benefit for surgery. The advantage of muscular CT-scanning in other forms of arthrogryposis requires further determination. The differential diagnosis with Werdnig-Hoffmann disease is discussed.

Nickel alloys and high-alloyed special stainless steels. Properties, manufacturing, applications. 4. compl. rev. ed.

International Nuclear Information System (INIS)

Heubner, Ulrich; Kloewer, Jutta; Alves, Helena; Behrens, Rainer; Schindler, Claudius; Wahl, Volker; Wolf, Martin

2012-01-01

This book contains the following eight topics: 1. Nickel alloys and high-alloy special stainless steels - Material overview and metallurgical principles (U. Heubner); 2. Corrosion resistance of nickel alloys and high-alloy special stainless steels (U. Heubner); 3. Welding of nickel alloys and high-alloy special stainless steels (T. Hoffmann, M. Wolf); 4. High-temperature materials for industrial plant construction (J. Kloewer); 5. Nickel alloys and high-alloy special stainless steels as hot roll clad composites-a cost-effective alternative (C. Schindler); 6. Selected examples of the use of nickel alloys and high-alloy special stainless steels in chemical plants (H. Alves); 7. The use of nickel alloys and stainless steels in environmental engineering (V. Wahl); 8: Nickel alloys and high-alloy special stainless steels for the oil and gas industry (R. Behrens).

A case of asymmetrical arthrogryposis

International Nuclear Information System (INIS)

Hageman, G.; Vette, J.K.; Willemse, J.

1983-01-01

Following the introduction of the conception that arthrogryposis is a symptom and not a clinical entity, a case of the very rare asymmetric form of neurogenic arthrogryposis is presented. The asymmetry of congenital contractures and weakness is associated with hemihypotrophy. The value of muscular CT-scanning prior to muscle biopsy is demonstrated. Muscular CT-scanning shows the extension of adipose tissue, which has replaced damaged muscles and therby indicates the exact site for muscle biopsy. Since orthopaedic treatment in arthrogryposis can be unrewarding due to severe muscular degeneration, preoperative scanning may provide additional important information on muscular function and thus be of benefit for surgery. The advantage of muscular CT-scanning in other forms of arthrogryposis requires further determination. The differential diagnosis with Werdnig-Hoffmann disease is discussed. (author)

Consumer evaluation of imported organic food products in emerging economies in Asia

DEFF Research Database (Denmark)

Pedersen, Susanne; Aschemann-Witzel, Jessica; Thøgersen, John

, product image and consumer purchase intention: Evidence from an emerging economy. International Business Review, 21(6), 1041-1051. doi:http://dx.doi.org/10.1016/j.ibusrev.2011.11.010 Wang, O., De Steur, H., Gellynck, X., & Verbeke, W. (2015). Motives for consumer choice of traditional food and European......-country combinations in every product category (Pappu, Quester, & Cooksey, 2006, 2007). A country-of-origin-effect strong enough to drive purchasing decisions appears when a country’s equity is high and there is a good product-country match (S. A. Ahmed, d'Astous, & Petersen, 2011; Herz & Diamantopoulos, 2013; Roth......, preferences and purchase behaviour (Newman, Turri, Howlett, & Stokes, 2014). A wide range of contingencies and moderators of COO effects has been identified (Pharr, 2005; Verlegh & Steenkamp, 1999) – also for food products (Z. U. Ahmed et al., 2004; Chryssochoidis, Krystallis, & Perreas, 2007; Hoffmann, 2000...

IN SUBJECTS ALLERGIC TO GRASS POLLEN, BASOPHIL SENSITIVITY DECREASES DURING SUBCUTANEOUS IMMUNOTHERAPY DUE TO BOTH HUMORAL FACTORS AND CELLULAR DESENSITIZATION

DEFF Research Database (Denmark)

Schmid, Johannes Martin; Dahl, Ronald; Hoffmann, Hans Jürgen

2011-01-01

Johannes Martin Schmid, Ronald Dahl, and Hans Juergen Hoffmann Department of Respiratory Medicine, Aarhus, Denmark Background: The major effect of SCIT is a change in allergen specific immunoglobulin. We measure the contribution of competing immunoglobulin to the effect of SCIT in patients...... with allergic rhino-conjunctivitis with basophil activation tests (BAT). Methods: We have randomized 24 patients to a treatment (18) and an open control group (6). Repeated BAT were performed at baseline and througout treatment. Heparinized blood was centrifuged, plasma was removed, the cells washed twice...... basophils. The LC50 was calculated as the log of the allergen concentration leading to half maximum basophil activation. Specific IgE and IgG4 was measured using ISAC panel. Results: We found a 15-fold reduction in basophil sensitivity in the treated group during updosing, compared to their baseline...

Effect of Protein Hydrolysates on Pancreatic Cancer Cells

DEFF Research Database (Denmark)

Ossum, Carlo G.; Andersen, Lisa Lystbæk; Nielsen, Henrik Hauch

Effect of Fish Protein Hydrolysates on Pancreatic Cancer Cells Carlo G. Ossum1, Lisa Lystbæk Andersen2, Henrik Hauch Nielsen2, Else K. Hoffmann1, and Flemming Jessen2 1University of Copenhagen, Department of Biology, Denmark, 2Technical University of Denmark (DTU), National Food Institute, Denmark...... hydrolysates obtained by enzymatic hydrolysis on cancer cell proliferation. Skin and belly flap muscle from trout were hydrolysed with the unspecific proteases Alcalase, Neutrase, or UE1 (all from Novozymes, Bagsværd, Denmark) to a hydrolysis degree of 1-15%. The hydrolysates were tested for biological...... activities affecting cell proliferation and ability to modulate caspase activity in pancreatic cancer cells COLO357 and BxPC-3 in vitro. A number of the hydrolysates showed caspase promoting activity; in particular products containing muscle tissue, i.e. belly flap, were able to stimulate caspase activity...

An International Collaborative Study of Outcome and Prognostic Factors in Patients with Secondary CNS Involvement By Diffuse Large B-Cell Lymphoma

DEFF Research Database (Denmark)

El-Galaly, Tarec Christoffer; Cheah, Chan Yoon; Bendtsen, Mette Dahl

2016-01-01

that develop SCNS following primary therapy that contains a rituximab-based-regimen as well as the impact of more intensified treatment for SCNS are limited.Aims: The aims of this study were to i) describe the natural history of SCNS in a large cohort of patients treated with immunochemotherapy, and ii......' Hospital, London). Clinico-pathologic and treatment characteristics at the time of SCNS were collected from medical records.Results: In total, 281 patients with SCNS diagnosed between 2001 and 2016 were included. Median age at SCNS was 64 (range 20-93) years and male:female ratio was 1.3. SCNS occurred...... Myers Squib: Research Funding; NanoString Technologies: Research Funding; F Hoffmann-La Roche: Research Funding; Millennium Takeda: Research Funding; Seattle Genetics: Research Funding. Sehn: roche/genentech: Consultancy, Honoraria; amgen: Consultancy, Honoraria; seattle genetics: Consultancy, Honoraria...

Reading a suspenseful literary text activates brain areas related to social cognition and predictive inference.

Directory of Open Access Journals (Sweden)

Moritz Lehne

Full Text Available Stories can elicit powerful emotions. A key emotional response to narrative plots (e.g., novels, movies, etc. is suspense. Suspense appears to build on basic aspects of human cognition such as processes of expectation, anticipation, and prediction. However, the neural processes underlying emotional experiences of suspense have not been previously investigated. We acquired functional magnetic resonance imaging (fMRI data while participants read a suspenseful literary text (E.T.A. Hoffmann's "The Sandman" subdivided into short text passages. Individual ratings of experienced suspense obtained after each text passage were found to be related to activation in the medial frontal cortex, bilateral frontal regions (along the inferior frontal sulcus, lateral premotor cortex, as well as posterior temporal and temporo-parietal areas. The results indicate that the emotional experience of suspense depends on brain areas associated with social cognition and predictive inference.

Movement Behavior of High-Heeled Walking

DEFF Research Database (Denmark)

Alkjær, Tine; Raffalt, Peter Christian; Petersen, Nicolas Caesar

2012-01-01

The human locomotor system is flexible and enables humans to move without falling even under less than optimal conditions. Walking with high-heeled shoes constitutes an unstable condition and here we ask how the nervous system controls the ankle joint in this situation? We investigated the movement...... behavior of high-heeled and barefooted walking in eleven female subjects. The movement variability was quantified by calculation of approximate entropy (ApEn) in the ankle joint angle and the standard deviation (SD) of the stride time intervals. Electromyography (EMG) of the soleus (SO) and tibialis...... anterior (TA) muscles and the soleus Hoffmann (H-) reflex were measured at 4.0 km/h on a motor driven treadmill to reveal the underlying motor strategies in each walking condition. The ApEn of the ankle joint angle was significantly higher (p...

[Profile of Shohei Ninomiya (pharmacist), the first Japanese medical representative to practice modern European-style propaganda in the late Meiji era].

Science.gov (United States)

Nishikawa, Takashi

2007-01-01

A Swiss pharmaceutical company (F-Hoffmann-La Roche Ltd.), first introduced the profession of "propagandist" in Japan in 1912. At the time, Shohei Ninomiya was a chief hospital pharmacist, but he changed his vocation to become the first "propah" (Japanese abbreviation for propagandist). The German physician Dr. Rudolf Ebering initiated Dr. Ninomiya in the methods and principles of "propah," and he faithfully practiced them. The defining principle of a modern European propagandist is one who is far from sales-centered. From the late 1970s through 1980s, however, Japanese pharmaceutical companies indulged in pursuing sales and neglected this principle, resulting in numerous abuses and adverse effects. Today, use of the description "medical representative" (MR) is more common than "propah." Even with this different description, pharmaceutical companies and MRs should never neglect the founding principle to avoid repeating such abuses.

Mr Erkki Liikanen, European Commissioner for Enterprise and Information Society

CERN Multimedia

Maximilien Brice

2003-01-01

Photo 01: Visit of Mr Erkki Liikanen, at CMS experiment assembly hall at Point 5, L. to r.: : Mr Mario Campolargo, Head of Unit, Research Infrastructure, DG Information Society; Prof. Dan-Olof Riska, Director, Helsinki Institute of Physics; Prof. Ari-Pekka Hameri, HEC, University of Lausanne, Helsinki Institute of Physics; Mr Wolfgang Boch, Head of Unit, Grids for Complex Problems Solving, DG Information Society; Mr David O. Williams, Relations with the European Commission; Mr Erkki Liikanen, European Commissioner for Enterprise and Information Society; Dr Hans F. Hoffmann, Director for Technology Transfer and for Scientific Computing; Prof. Jorma Tuominiemi, Director of the CMS Programme for the Helsinki Institute of Physics; H.E. Mr Carlo Trojan, Ambassador, Head of the permanent delegation of the European Commission to the international organizations in Geneva; Prof. Erkko Autio, Helsinki University of Technology, Institute of Strategy & International Business. Photo 02: Prof. Dan-Olof Riska, Director,...

CERN signs draft Memorandum of Understanding with Iran

CERN Multimedia

2001-01-01

Left to right: Dr Henrik Foeth, Team Leader CMS; Dr Daniel Denegri, Physics Coordinator CMS; Prof. Tejinder Virdee, Deputy Spokesman CMS; Prof. Luciano Maiani, CERN Director-General - signing; Mr Jean-Marie Dufour, Head of the CERN Legal Service, Mr Ghodratollah Habibpour Gharakol, back; Dr Abdolali Sharghi, Advisor to the Minister and Director General, Office of International Scientific Cooperation, Iranian Ministry of Science, Research and Technology; Dr Mostafa Moin, Minister of Science, Research and Technology, Islamic Republic of Iran - signing; Dr Reza Mansouri, Director, International Scientific Meetings Office, Iranian Ministry of Science, Research and Technology; H. E. Dr Ali Khorram, Extraordinary and plenipotentiary Ambassador of the Islamic Republic of Iran to the United Nations in Geneva, Dr Hans F. Hoffmann, CERN Director for Technology Transfer & for Scientific Computing. Iranian Minister for Science, Research and Technology, Dr Mostafa Moin, and CERN Director-General Luciano Maiani, s...

Reflections on evaluative practice in higher education: an experience collaborative

Directory of Open Access Journals (Sweden)

Suênya Marley Mourão Batista

2016-12-01

Full Text Available This article aims to reflect on the evaluation practice of higher education teachers generated from research conducted as part of a private higher education institution. The objective of this study is to characterize the assessment practices of teachers who work in higher education and collaborate in order to facilitate the expansion of dynamic assessment practices were used as theoretical and methodological support the studies of Vygotsky (2007, Liberali (2008, Ibiapina (2007, 2008, Meier (2007, Campione (2002 and Hoffmann (2011. Field research was conducted in a qualitative approach to collaborative type with 3 (three in higher education using the reflective interview as data collection tool to promote critical thinking about assessment practices to develop. The results showed the prevalence of use of traditional assessment practices by teachers and the possibility of performing dynamic assessment practices from the understanding of these nurtured by the research and training process.

Possible resonance effect of axionic dark matter in Josephson junctions.

Science.gov (United States)

Beck, Christian

2013-12-06

We provide theoretical arguments that dark-matter axions from the galactic halo that pass through Earth may generate a small observable signal in resonant S/N/S Josephson junctions. The corresponding interaction process is based on the uniqueness of the gauge-invariant axion Josephson phase angle modulo 2π and is predicted to produce a small Shapiro steplike feature without externally applied microwave radiation when the Josephson frequency resonates with the axion mass. A resonance signal of so far unknown origin observed by C. Hoffmann et al. [Phys. Rev. B 70, 180503(R) (2004)] is consistent with our theory and can be interpreted in terms of an axion mass m(a)c2=0.11  meV and a local galactic axionic dark-matter density of 0.05  GeV/cm3. We discuss future experimental checks to confirm the dark-matter nature of the observed signal.

[H reflex in patients with spastic quadriplegia].

Science.gov (United States)

Miyama, Sahoko; Arimoto, Kiyoshi; Kimiya, Satoshi

2009-01-01

Hoffmann reflex (H reflex) is an electrically elicited spinal monosynaptic reflex. H reflex was examined in 18 patients with spastic quadriplegia who had perinatal or postnatal problems. H reflex was elicitable in 11 patients for the abductor pollicis brevis (61.1%), 10 for the abductor digiti minimi (55.6%) and 16 for the abductor hallucis (88.9%). Because the abductor pollicis brevis and the abductor digiti minimi do not exhibit H reflex in normal subjects, it was suggested that the excitability of alpha motor neurons innervating these muscles was increased. H reflex was not detected for the extensor digitorum brevis in any patients, indicating the difference in the excitability among alpha motor neurons. In some patients, H reflex did not disappear under supramaximal stimuli. We conclude that the mechanism of evolution of H reflex in patients with spastic quadriplegia is different from that in normal subjects.

["Pharmaco-theology"].

Science.gov (United States)

Krafft, F

1996-06-01

Physico-theology is a way of thinking and argumentation, especially of the protestantism during enlightenment, which, facing the new, namely causal-mechanical natural science, emphasizes the anthropocentrical expediency of creation (of the "liber naturae'), traces it in nature and therefrom derives God's omnipotence, grace and wisdom. Although physico-theological writings of the 18th century are treating all kinds of natural objects under this aspect, the herbs and natural remedies never have been mentioned in the historical research of physico-theology until now. Here, this gap is closed. The relevant writings by Friedrich Hoffmann, Johann Julius Hecker und Julius Bernhard von Rohr are briefly presented and thereby attention is drawn to an important zeitströmung which added substantially to a broad acceptance of medicaments which then formed the practical basis as one of the preconditions for the developing of pharmacy into science in the late 18th century.

Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues.

Science.gov (United States)

Djidja, Marie-Claude; Claude, Emmanuelle; Scriven, Peter; Allen, David W; Carolan, Vikki A; Clench, Malcolm R

2017-07-01

MALDI-mass spectrometry imaging (MALDI-MSI) has been shown to allow the study of protein distribution and identification directly within formalin-fixed paraffin-embedded (FFPE) tissue sections. However, direct protein identification from tissue sections remains challenging due to signal interferences and/or existing post-translational or other chemical modifications. The use of antigen retrieval (AR) has been demonstrated for unlocking proteins prior to in situ enzymatic digestion and MALDI-MSI analysis of FFPE tissue sections. In the work reported here, the identification of proline oxidation, which may occur when performing the AR protocol, is described. This facilitated and considerably increased the number of identified peptides when adding proline oxidation as a variable modification to the MASCOT search criteria. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2016 Elsevier B.V. All rights reserved.

Software development agreement between CERN and the Indian Department of Atomic Energy

CERN Multimedia

Patrice Loïez

2003-01-01

The development and prototyping work for the LHC computing facility is being organised as a project that includes many scientific institutes and industrial partners, coordinated by CERN. The project is nicknamed LCG (after LHC Computing Grid). Addendum No. 1 to the Protocol dated 24/09/02 to the 1991 co-operation agreement between CERN and the Department of Atomic Energy (DAE) of the Government of India defines the collaboration between CERN and DAE on software development for the LCG Prototype Project. Photo 01: Signing the addendum are G. Govindrajan (left), Director of the Electronics and Instrumentation Group at the Bhabha Atomic Research Centre, Mumbai, India and Dr. Hans Hoffmann, CERN Director for Technology Transfer and for Scientific Computing. Looking on are Christoph Eck (far left), resource manager of the LCG Project and Les Robertson, LCG Project Leader. Photo 02: (left to right) Christoph Eck, resource manager of the LCG Project; G. Govindrajan, Director of the Electronics and Instrumentation G...

Grid Technologies: scientific and industrial prospects

CERN Multimedia

2002-01-01

On Friday 27th, 17:00-21:00, CERN will for the first time be host to the popular 'First Tuesday Geneva' events for entrepreneurs, investors and all those interested in how new technologies will impact industry. Organised by the non-profit group Rezonance, these evening events typically attract over 300 persons, and combine a series of short presentations on a hot topic with an informal networking session. The topic for this 'First Tuesday@CERN' is Grid Technologies. Over the last year, the concept of a Grid of geographically distributed computers providing huge computing resources 'on tap' to companies and institutions has led to a great deal of interest and activity from major computer hardware and software companies. The session is hosted by the CERN openlab for DataGrid applications, a recently established industrial partnership on Grid technologies, and will profile both CERN's activities in this emerging field and those of some key industrial players. Speakers include: Hans Hoffmann: CERN, The LHC a...

Intramuscular Neurotrophin-3 normalizes low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats.

Science.gov (United States)

Kathe, Claudia; Hutson, Thomas Haynes; McMahon, Stephen Brendan; Moon, Lawrence David Falcon

2016-10-19

Brain and spinal injury reduce mobility and often impair sensorimotor processing in the spinal cord leading to spasticity. Here, we establish that complete transection of corticospinal pathways in the pyramids impairs locomotion and leads to increased spasms and excessive mono- and polysynaptic low threshold spinal reflexes in rats. Treatment of affected forelimb muscles with an adeno-associated viral vector (AAV) encoding human Neurotrophin-3 at a clinically-feasible time-point after injury reduced spasticity. Neurotrophin-3 normalized the short latency Hoffmann reflex to a treated hand muscle as well as low threshold polysynaptic spinal reflexes involving afferents from other treated muscles. Neurotrophin-3 also enhanced locomotor recovery. Furthermore, the balance of inhibitory and excitatory boutons in the spinal cord and the level of an ion co-transporter in motor neuron membranes required for normal reflexes were normalized. Our findings pave the way for Neurotrophin-3 as a therapy that treats the underlying causes of spasticity and not only its symptoms.

188Re labeled MPEG-modified superparamagnetic nanogels: preparation and preliminary application in mice

International Nuclear Information System (INIS)

Sun Hanwen; Gong Peijun; Liu Xiuqing; Hong Jun; Xu Dongmei; Zhang Chunfu; Wang Yongxian; Yao Side

2005-01-01

Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly(ethylene glycol) (MPEG) for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction (XRD), photo correlation spectroscopy (PCS) and scanning electron microscopy (SEM), respectively. The MPEG-modified magnetic nanogels were labeled by 188 Re radiopharmaceuticals and intravenously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bellies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character. (authors)

Acetylsalicylic acid: Incoming 150 years of the first synthesis

Directory of Open Access Journals (Sweden)

Mijin Dušan Ž.

2002-01-01

Full Text Available Acetylsalicylic acid is one of the most fascinating and versatile drugs known to medicine, as well as one of the oldest. Acetylsalicylic acid is a drug which is safe, with analgetic, antirheumatic, anti-inflammatory antiplatelet and antithrombotic action. It may be applied not only in clinical practice, but also as prevention. The first known use of an acetylsalicylic acid-like preparation can be traced to ancient Greece. In 1853 Charles Gerhardt published the first synthesis of acetylsalicylic acid. Felix Hoffmann, a chemist for Friedrich Bayer, a German dye company obtained a patent on acetylsalicylic acid some 40 years later. Bayer coined the name Aspirin for the new product. The 20 in century was the century in which many researchers in many companies tried to improve the synthesis of acetylsalicylic acid not only in terms of yield but also purity. This paper describes the history, use, mechanism of action, synthesis and production as well as the purification and stability of acetylsalicylic acid.

Otto Hahn achievement and responsibility

CERN Document Server

Hoffmann, Klaus

2001-01-01

Otto Hahn (1879-1968) was awarded the 1944 Nobel Prize for Chemistry for his work on atomic fission: his work in Berlin in the 1930s and 1940s with Lise Meitner and Fritz Strassmann led to the discovery that uranium nuclei bombarded by neutrons undergo spontaneous fission, releasing enormous energies. This work, conveyed to England and the US by scientific refugees from Nazi Germany, led to the instigation of the Manhattan Project and the development of the Atomic Bomb. Reviled by many after the war as one of the people responsible for the carnage at Hiroshima and Nagasaki, Hahn had already begun to reflect on the social responsibility of scientists for their fundamental discoveries and the subsequent applications of the knowledge they create. Already during the war, Hahn had protested Nazi restrictions on Universities and researchers, and after the War, he became actively involved in efforts to restrict the spread of nuclear weapons. In this volume Klaus Hoffmann discusses Hahn's contributions to science and...

Correlation of 18F-FDG PET/CT and Endoscopic Findings of Twin Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Stomach: Report of a Case

International Nuclear Information System (INIS)

Bahk, Yong Whee; Choi, Jin Wook

2008-01-01

Mucosa-associated lymphoid tissue (MALT) type lymphoma arises from extranodal marginal zone B-cell. It is etiologically associated with Helicobacter pylori infection and, hence, can be cured by antibiotic treatment. MALT type lymphoma is the most common variety of gastric lymphoma that is rare in the stomach). The published data of clinical studies on the usefulness of 18F-FDG PET in the diagnosis of MALT type lymphoma varied according to authors. Thus, the result of Hoffmann et al. was discouraging whereas a high diagnostic accuracy was reported by Ambrosini et al. The latter group further went to suggest that higher 18F-FDG uptake in gastric MALT type lymphoma would positively relate to the aggressiveness of neoplasm. The clinical studies conducted by other groups on MALT lymphomas of the stomach, lung, orbit and parotid gland and the stomach, lung, parotid gland, skin, orbit, mandible, esophagus and uterus confirmed that 18F-FDG scan is valuable

A New Phase in Cancer Research at CERN

CERN Multimedia

2002-01-01

The first meeting of the ENLIGHT network, set up to co-ordinate the development of light ion cancer therapy projects in Europe, took place at CERN last week. This is a form of therapy ideally suited to the treatment of deep-seated tumours and those near critical organs. Hans Hoffmann, Director for Technology transfer and scientific computing, and Director General Luciano Maiani during the opening of the first meeting of the ENLIGHT network that was held at CERN last week. The fruit of several years of work, this meeting offers new hope for the treatment of certain types of cancer. Around 70 specialists, including radiotherapists, oncologists, physicists and engineers, got together at CERN for the first meeting of a European cancer therapy research network named ENLIGHT (European Network for research in LIGHt ion Therapy(1)). This initiative, headed by oncologists and funded by the European Commission, aims to promote the development of light ion (hadron) therapy projects. The choice of CERN as a venue for ...

Using Drama to Promote Argumentation in Science Education. The Case of "Should've"

Science.gov (United States)

Archila, Pablo Antonio

2017-05-01

The purpose of this study was to use drama as a springboard for promoting argumentation among 91 first-semester undergraduate medical students (56 females and 35 males, 16-30 years old) in Colombia during a complete teaching-learning sequence (TLS) supervised by the same teacher. The drama used was the play Should've, written by Nobel laureate Roald Hoffmann. The data was derived from students' written responses, audio and video recordings, and written field notes. This investigation provides evidence that an approach combining drama and argumentation could increase students' awareness of the relevance of ethics in science as one of the features of science (FOS). The findings show that the play Should've can be useful for promoting students' argumentation and is also appropriate for medical students. Future studies could include other science disciplines (e.g., astronomy, biology, chemistry, earth science, ecology, physics); students of other ages; and other plays and experiments in other parts of the world.

Fragments of a Hungarian Past in the Literature of 1.5 and Second-Generation Austro-Hungarian Immigrants in Israel

Directory of Open Access Journals (Sweden)

Ilana Rosen

2015-01-01

Full Text Available Contemporary Israeli literature is presently preoccupied with the past diasporic lives of the previous generation, the one that came to Israel from practically all four winds in the mid-late twentieth century. Hungarian-Israeli writers—e.g., Yoel Hoffmann, Judith Rotem, Yael Neeman and Esti G. Hayim—constitute a distinct group within this stream of 1.5 and second generation poets and novelists who have written about immigration and State foundation, often using a documentary or fictionalized memoirist mode. This article highlights the components of these writers' complex burden of a whole world destroyed, in most cases, not long before they were born and which they strive to restore or at least re-imagine in their oeuvre as contemporary Israeli writers. These components include: Holocaust trauma and its transference to the second generation, Hungarian speaking families within the Israeli multicultural setting, the ties of these families with their Hungarian foreign relatives, and household objects related to this past.

Ethics, a neglected dimension of power relationships of physician leaders.

Science.gov (United States)

Chervenak, Frank A; McCullough, Laurence B; Baril, Thomas E

2006-09-01

Physician leaders in obstetrics and gynecology find themselves in complex power relationships with administrative subordinates, administrative peers, and administrative superiors. The ethical dimensions of these power relationships have not been examined previously. The authors draw on the work of 3 major historic figures (John Gregory, Thomas Hobbes, and Friedrich Hoffmann) to identify for the first time 3 major types of power relationships and organizational cultures. Gregorian power relationships and organizational cultures are characterized by shared fiduciary responsibility that advances the core mission of a health care organization. Hobbesian power relationships and organizational cultures are characterized by relentless self-interest in a zero-sum game. Hoffmannian power relationships and organizational cultures are characterized by enlightened self-interest in a win-win game. The authors analyze the ethical dimensions of power relationships of physician leaders with subordinates, peers, and superiors and of organizational cultures. The authors support transformational leadership toward Gregorian power relationships and organizational cultures, using, when necessary, Hoffmannian power relationships and organizational cultures as a way station.

Correlation of {sup 18}F-FDG PET/CT and Endoscopic Findings of Twin Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Stomach: Report of a Case

Energy Technology Data Exchange (ETDEWEB)

Bahk, Yong Whee; Choi, Jin Wook [SungAe Hospital, Seoul (Korea, Republic of)

2008-02-15

Mucosa-associated lymphoid tissue (MALT) type lymphoma arises from extranodal marginal zone B-cell. It is etiologically associated with Helicobacter pylori infection and, hence, can be cured by antibiotic treatment. MALT type lymphoma is the most common variety of gastric lymphoma that is rare in the stomach). The published data of clinical studies on the usefulness of 18F-FDG PET in the diagnosis of MALT type lymphoma varied according to authors. Thus, the result of Hoffmann et al. was discouraging whereas a high diagnostic accuracy was reported by Ambrosini et al. The latter group further went to suggest that higher 18F-FDG uptake in gastric MALT type lymphoma would positively relate to the aggressiveness of neoplasm. The clinical studies conducted by other groups on MALT lymphomas of the stomach, lung, orbit and parotid gland and the stomach, lung, parotid gland, skin, orbit, mandible, esophagus and uterus confirmed that 18F-FDG scan is valuable.

International Symposium 100 Years of Chemical Warfare : Research, Deployment, Consequences

CERN Document Server

Hoffmann, Dieter; Renn, Jürgen; Schmaltz, Florian; Wolf, Martin; One hundred years of chemical warfare : research, deployment, consequences; 100 Jahre Giftgaskrieg : Forschung, Einsatz, Folgen chemischer Massenvernichtungswaffen

2017-01-01

On April 22, 1915, the German military released 150 tons of chlorine gas at Ypres, Belgium. Carried by a long-awaited wind, the chlorine cloud passed within a few minutes through the British and French trenches, leaving behind at least 1,000 dead and 4,000 injured. This chemical attack, which amounted to the first use of a weapon of mass destruction, marks a turning point in world history. The preparation as well as the execution of the gas attack was orchestrated by Fritz Haber, the director of the Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry in Berlin-Dahlem. During World War I, Haber transformed his research institute into a center for the development of chemical weapons (and of the means of protection against them). Bretislav Friedrich and Martin Wolf (Fritz Haber Institute of the Max Planck Society, the successor institution of Haber’s institute) together with Dieter Hoffmann, Jürgen Renn, and Florian Schmaltz (Max Planck Institute for the History of Science) organized an inte...

The Eroticism of Artificial Flesh in Villiers de L'Isle Adam's L'Eve Future

Directory of Open Access Journals (Sweden)

Patricia Pulham

2008-10-01

Full Text Available Villiers de L'Isle Adam's 'L'Eve Future' published in 1886 features a fictional version of the inventor Thomas Edison who constructs a complex, custom-made android for Englishman Lord Ewald as a substitute for his unsatisfactory lover. Hadaly, the android, has a number of literary and cultural precursors and successors. Her most commonly accepted ancestor is Olympia in E. T. A. Hoffmann's 'The Sandman' (1816 and among her fascinating descendants are Oskar Kokoschka's 'Silent Woman'; Model Borghild, a sex doll designed by German technicians during World War II;‘Caracas' in Tommaso Landolfi's short story ‘Gogol's Wife' (1954; a variety of gynoids and golems from the realms of science fiction, including Ira Levin's 'Stepford Wives' (1972; and, most recently, that silicon masterpiece - the Real Doll. All, arguably, have their genesis in the classical myth of Pygmalion. This essay considers the tension between animation and stasis in relation to this myth, and explores the necrophiliac aesthetic implicit in Villiers's novel.

[A pharmaceutical of the century will be 100. A historical vignette on the introduction of acetylsalicylic acid to the market in 1899].

Science.gov (United States)

Kohl, F

1999-10-15

This article describes the historic roots of acetylsalicylic acid (ASA) from the first experiments at 1800 until the introduction into the pharmaceutical market in 1899. In 1869, Hermann Kolbe enlightened the chemical structure of salicylic acid, which was used at that time as an analgetic and antipyretic drug. Because of the side effects, for example the irritation of the stomach, analytical chemists and pharmacologists searched for chemical modifications. In August 1897 Felix Hoffmann (1868-1946) was successful in acetylizing the salicylic acid to acetylsalicylic acid (ASA). Between 1897 and 1899 Kurt Witthauer (1865-1911) collected clinical data and experiences on the efficiency of ASA as an analgetic and antipyretic drug. In 1899 ASA was introduced into the pharmaceutical market as Aspirin and became soon one of the most successful drugs of its time. The indication exceeds analgesia in the mean time and to prophylaxis of myocardial ischaemia or cerebral stroke, among others.

CFSP and the Theories of European Integration: the Contributions of the “New Intergovernmentalisms”

Directory of Open Access Journals (Sweden)

Mónica Salomón

1999-10-01

Full Text Available The lack of connection between the analysis of the so-called “European foreign policy” and the theories of European integration has had very negative consequences. European Political Cooperation (EPC and Common Foreign and Security Policy (CFSP’s studies have been developed in a “theoretical void” that has not contributed to theunderstanding of the phenomenon of foreign-policy coordination between European Union’s member states. The reasons for the estrangement lie mainly in the incapacity of the dominant supranational paradigm to explain the intergovernamental shift whichexperienced the EC in the mid-sixties. In fact, EPC is itself a product of the intergovernmental shift. But the situation has changed in this last decade. Integration theories are flourishing again. In particular, the contributions of a group of authors which can be classified as “new intergovernmentalists” (Keohane and Hoffmann, Moravcsik and Taylor are promissing. They provide both a common framework of analysis for the intergovernmentalist EU’s pillars and its communitarian domains and some elements which help understand the specificities of the foreign policy coordination mechanism.

New therapy of pleural empyema by deoxyribonuclease

Directory of Open Access Journals (Sweden)

Grzegorz Kacprzak

2013-02-01

Full Text Available Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG in dosage 2 × 2.5 mg with a significant improvement caused by changes in pus viscosity.

Carbohydrates in sustainable development I. Renewable resources for chemistry and biotechnology

Energy Technology Data Exchange (ETDEWEB)

Rauter, Amelia, P. [Lisboa Univ. (Portugal). Dept. Quimica e Bioquimica; Vogel, Pierre [Swiss Institute of Technology (EPFL), Lausanne (Switzerland). Lab. of Glycochemistry and Asymmetric Synthesis; Queneau, Yves (eds.) [Lyon Univ. Villeurbanne (France). Inst. de Chimie et Biochimie

2010-07-01

Sucrose: A Prospering and Sustainable Organic Raw Material, By S. Peters, T. Rose, and M. Moser; Sucrose-Utilizing Transglucosidases for Biocatalysis, By I. Andre, G. Potocki-Veronese, S. Morel, P. Monsan, and M. Remaud-Simeon; Difructose Dianhydrides (DFAs) and DFA-Enriched Products as Functional Foods, By C. Ortiz Mellet and J. M. Garcia Fernandez; Development of Agriculture Left-Overs: Fine Organic Chemicals from Wheat Hemicellulose-Derived Pentoses, By F. Martel, B. Estrine, R. Plantier-Royon, N. Hoffmann, and C. Portella; Cellulose and Derivatives from Wood and Fibers as Renewable Sources of Raw-Materials, By J.A. Figueiredo, M.I. Ismael, C.M.S. Anjo, and A.P. Duarte; Olive Pomace, a Source for Valuable Arabinan-Rich Pectic Polysaccharides, By M. A. Coimbra, S. M. Cardoso, and J. A. Lopes-da-Silva; Oligomannuronates from Seaweeds as Renewable Sources for the Development of Green Surfactants,By T. Benvegnu and J.-F. Sassi; From Natural Polysaccharides to Materials for Catalysis, Adsorption, and Remediation, By F. Quignard, F. Di Renzo, and E. Guibal. (orig.)

New therapy of pleural empyema by deoxyribonuclease

Directory of Open Access Journals (Sweden)

Grzegorz Kacprzak

Full Text Available Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG in dosage 2 × 2.5 mg with a significant improvement caused by changes in pus viscosity.

Redes de pequenas empresas: a aplicação de uma tipologia em uma rede de supermercados.

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Rivanda Meira Teixeira

2007-09-01

Full Text Available O presente estudo teve como objetivo analisar as características de uma rede do setor de comércio varejista, a Rede Econômica de Supermercados, de acordo com a tipologia de redes de empresas proposta por Hoffmann et al. (2004. Além disso, buscou-se identificar quais são os principais benefícios e dificuldades verificados na operacionalização da Rede. A partir de entrevistas realizadas com o gestor administrativo da Rede e com um gerente de compras, e com base na análise de documentos e material institucional, pode-se classificar a Rede como de cooperação horizontal, aglomerada, formal e não-orbital. As principais vantagens percebidas para os supermercados, com relação à participação na rede, foram a realização de ações de marketing e de compras conjuntas. A principal dificuldade apontada reside na conciliação dos objetivos do negócio com os objetivos individuais.

Capparidaceae: Stuebelia Pax, sinónimo de Belencita Karsten

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Dugand Armando

1944-03-01

Full Text Available El estudio de algunas Caparidáceas de Colombia me incito recientemente a examinar críticamente el género Relencita Karsten, descrito con una sola especie (B. Hagenii Karst. que crece en la costa del Mar Caribe, tanto en Venezuela como en Colombia. En la última recensión de las Caparidáceas, Pax y Hoffmann (en EngI. Pflanzenf. ed. 2, 17-b: 165 y 184. 1936 separan este género de Stuebelia Pax suponiendo que Stuebelia tiene ovario unilocular y Belencita bilocular.  Con todo, ladescripción original de Belencita Haqenii y del género Belencita así como la excelente ilustración que de esta planta ofrece Karsten, me han convencido de que se trata de la misma planta descrita en 1763 por Jacquin con el nombre Capparis nemorosa y que yo transferí en 1935 al género stuebelia. Por lo tanto se necesita hacer un cambio nomenclatural adscribiendo el epíteto nemorosa (1760-1763 al género Belencita (1857 descrito antes que Stuebelia (1887-1888.

ATLAS honours one of its suppliers

CERN Multimedia

2003-01-01

On 12 February the Netherlands firm Schelde Exotech was awarded a prize for best ATLAS supplier for the construction of the two vacuum chambers for the ATLAS endcap toroid magnets. The award for best supplier is handed over to representatives of the firm Schelde Exotech in front of one of the two vacuum chambers built by the firm. From left to right: E. Baynham (RAL), H. Geerink (NIKHEF), Y. Lefevere (NIKHEF), J. Engelen (NIKHEF), P. Jenni (CERN), E. Holtom (RAL), R. Boddaert (Schelde Exotech), G. Luijckx (NIKHEF), H. Klumpus (Schelde Exotech), M. Nessi (CERN), H. ten Kate (CERN), M. Nordberg (CERN), H. Hoffmann (CERN).This ceremony has now become something of a tradition. For the third consecutive year, ATLAS has given best supplier awards for the most exceptional contributors to the construction of the future detector. The Netherlands firm Schelde Exotech has just received the award for the construction of the two vacuum chambers for the ATLAS endcap toroid magnets. With a diameter of 11 metres and a volum...

Cooperative resources lead to sustainable competitive advantage

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Fernando Vieira

2016-11-01

Full Text Available The objective of this research is to analyze how organizational resources contribute to cooperatives achieving a sustainable competitive advantage. The theoretical approach of this study is the Resource Based View and VRIO model advocated by Barney and Hesterly (2007. The research was characterized as descriptive and quantitative, through data collection from secondary sources and a survey. The data collection tool was a questionnaire devised by Peacock, Sehnem and Hoffmann (2011. Data collection took place between the months of September 2014 and March 2015. The study sample was composed of a total of 215 cooperatives from across the country, divided into 13 segments. Secondary data was subjected to content analysis. The primary data was analyzed using statistical inference, namely: descriptive statistics, mean, Pearson correlation, Varimax rotation and the Kruskal-Wallis test. The main results showed that human resources are seen as important to achieving a sustainable competitive advantage. This research contributed to and enables new studies concerning the growth of cooperatives taking into account the use of internal resources.

The LHC Computing Grid Project

CERN Multimedia

Åkesson, T

In the last ATLAS eNews I reported on the preparations for the LHC Computing Grid Project (LCGP). Significant LCGP resources were mobilized during the summer, and there have been numerous iterations on the formal paper to put forward to the CERN Council to establish the LCGP. ATLAS, and also the other LHC-experiments, has been very active in this process to maximally influence the outcome. Our main priorities were to ensure that the global aspects are properly taken into account, that the CERN non-member states are also included in the structure, that the experiments are properly involved in the LCGP execution and that the LCGP takes operative responsibility during the data challenges. A Project Launch Board (PLB) was active from the end of July until the 10th of September. It was chaired by Hans Hoffmann and had the IT division leader as secretary. Each experiment had a representative (me for ATLAS), and the large CERN member states were each represented while the smaller were represented as clusters ac...

A short history of anti-rheumatic therapy. II. Aspirin

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P. Marson

2011-06-01

Full Text Available The discovery of aspirin, an antipyretic, anti-inflammatory and analgesic drug, undoubtedly represents a milestone in the history of medical therapy. Since ancient times the derivatives of willow (Salix alba were used to treat a variety of fevers and pain syndromes, although the first report dates back to 1763 when the English Reverend Edward Stone described the effect of an extract of the bark willow in treating malaria. In the XIX century many apothecaries and chemists, including the Italian Raffaele Piria and Cesare Bertagnini, developed the biological processes of extraction and chemical synthesis of salicylates, and then analyzed their therapeutic properties and pharmacokinetic and pharmacodynamic characteristics. In 1899 the Bayer Company, where Felix Hoffmann, Heinrich Dreser and Arthur Eichengrün worked, recorded acetyl-salicylic acid under the name “Aspirin”. In the XX century, besides the definition of the correct applications of aspirin in the anti-rheumatic therapy being defined, Lawrence L. Crawen identified the property of this drug as an anti-platelet agent, thus opening the way for more widespread uses in cardiovascular diseases.

Numerical Methods for Free Boundary Problems

CERN Document Server

1991-01-01

About 80 participants from 16 countries attended the Conference on Numerical Methods for Free Boundary Problems, held at the University of Jyviiskylii, Finland, July 23-27, 1990. The main purpose of this conference was to provide up-to-date information on important directions of research in the field of free boundary problems and their numerical solutions. The contributions contained in this volume cover the lectures given in the conference. The invited lectures were given by H.W. Alt, V. Barbu, K-H. Hoffmann, H. Mittelmann and V. Rivkind. In his lecture H.W. Alt considered a mathematical model and existence theory for non-isothermal phase separations in binary systems. The lecture of V. Barbu was on the approximate solvability of the inverse one phase Stefan problem. K-H. Hoff­ mann gave an up-to-date survey of several directions in free boundary problems and listed several applications, but the material of his lecture is not included in this proceedings. H.D. Mittelmann handled the stability of thermo capi...

Cluster observations of continuous reconnection at the magnetopause under steady interplanetary magnetic field conditions

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T. D. Phan

2004-07-01

Full Text Available On 26 January 2001, the Cluster spacecraft detected high-speed plasma jets at multiple crossings of the high-latitude duskside magnetopause (MP and boundary layer (BL over a period of more than 2h. The 4 spacecraft combined spent more than half of this time in the MP/BL and jets were observed whenever a spacecraft was in the MP. These observations were made under steady southward and dawnward interplanetary magnetic field (IMF conditions. The magnetic shear across the local MP was ~100° and β~1 in the adjacent magnetosheath. The jet velocity is in remarkable agreement with reconnection prediction throughout the entire interval, except for one crossing that had no ion measurements inside the current layer. The flow speed measured in the deHoffmann Teller frame is 90% of the Alfvén speed on average for the 10 complete MP current layer crossings that are resolved by the ion measurements. These findings strongly suggest that reconnection was continuously active for more than two hours. The jets were directed persistently in the same northward and anti-sunward direction, implying that the X-line was always below the spacecraft. This feature is inconsistent with patchy and random reconnection or convecting multiple X-lines. The majority of MP/BL crossings in this two-hour interval were partial crossings, implying that they are caused by bulges sliding along the MP, not by inward-outward motion of a uniformly thin MP/BL. The presence of the bulges suggests that, although reconnection is continuously active under steady IMF conditions, its rate may be modulated. The present investigation also reveals that (1 the predicted ion D-shaped distributions are absent in all reconnection jets on this day, (2 the electric field fluctuations are larger in the reconnecting MP than in the magnetosheath proper, but their amplitudes never exceed 20mV/m, (3 the ion-electron differential motion is ~20km/s for the observed MP current density of ~50nA/m2 (∇× B, thus

Combination of geochemical and hydrobiological tracers for the analysis of runoff generating processes in a lowland catchment

Science.gov (United States)

Faber, Claas; Wu, Naicheng; Ulrich, Uta; Fohrer, Nicola

2015-04-01

EMMA dataset improves the ability to distinguish tile drainage, groundwater and surface runoff influence to streamflow in our agriculturally dominated lowland catchment. Keywords: tile drainage, surface runoff, groundwater, hydrograph separation, EMMA, dia-toms, water quality, lowland catchments References: Pfister L, Wetzel CE, Martínez-Carreras N, Frentress J, Ector L, Hoffmann L, McDonnell JJ. 2011. Do diatoms run downhill? Using biodiversity of terrestrial and aquatic diatoms to identify hydrological connectivity between aquatic zones in Luxembourg. AGU Fall Meeting. Tauro F, Martínez-Carreras N, Wetzel CE, Hissler C, Barnich F, Frentress J, Ector L, Hoff-mann L, McDonnell JJ, Pfister L. 2013. Fluorescent diatoms as hydrological tracers: a proof of concept percolation experiment. EGU abstract, EGU2013-7687-4.

Chronic Ankle Instability and Neural Excitability of the Lower Extremity.

Science.gov (United States)

McLeod, Michelle M; Gribble, Phillip A; Pietrosimone, Brian G

2015-08-01

Neuromuscular dysfunction of the leg and thigh musculature, including decreased strength and postural control, is common in patients with chronic ankle instability (CAI). Understanding how CAI affects specific neural pathways may provide valuable information for targeted therapies. To investigate differences in spinal reflexive and corticospinal excitability of the fibularis longus and vastus medialis between limbs in patients with unilateral CAI and between CAI patients and participants serving as healthy controls. Case-control study. Research laboratory. A total of 56 participants volunteered, and complete data for 21 CAI patients (9 men, 12 women; age = 20.81 ± 1.63 years, height = 171.57 ± 11.44 cm, mass = 68.84 ± 11.93 kg) and 24 healthy participants serving as controls (7 men, 17 women; age = 22.54 ± 2.92 years, height = 172.35 ± 10.85 cm, mass = 69.15 ± 12.30 kg) were included in the final analyses. Control participants were matched to CAI patients on sex, age, and limb dominance. We assigned "involved" limbs, which corresponded with the involved limbs of the CAI patients, to control participants. Spinal reflexive excitability was assessed via the Hoffmann reflex and normalized to a maximal muscle response. Corticospinal excitability was assessed using transcranial magnetic stimulation. Active motor threshold (AMT) was defined as the lowest transcranial magnetic stimulation intensity required to elicit motor-evoked potentials equal to or greater than 100 μV in 5 of 10 consecutive stimuli. We obtained motor-evoked potentials (MEPs) at percentages ranging from 100% to 140% of AMT. Fibularis longus MEP amplitudes were greater in control participants than in CAI patients bilaterally at 100% AMT (control involved limb: 0.023 ± 0.031; CAI involved limb: 0.014 ± 0.008; control uninvolved limb: 0.021 ± 0.022; CAI uninvolved limb: 0.015 ± 0.007; F1,41 = 4.551, P = .04) and 105% AMT (control involved limb: 0.029 ± 0.026; CAI involved limb: 0.021 ± 0

Cryptosporidium sp. in children suffering from acute diarrhea at Uberlândia City, State of Minas Gerais, Brazil

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Margareth Leitão Gennari-Cardoso

1996-10-01

Full Text Available This study's objective was to search for Cryptosporidium sp. in diarrheic feces from children aged zero to 12 years and cared for at medical units within Universidade Federal de Uberlândia or at a private practice in Uberlândia, State of Minas Gerais, Brazil, from September 1992 to August 1993. Three fecal samples preserved in 10% formalin, were collected from 94 children. Oocyst concentration was performed through Ritchie's (modified method and staining of fecal smears for each sample (total of 1128 slides was done by the "Safranin/Methylene Blue" and the "Kinyoun (modified" techniques. The Hoffmann, Pons & Janer method was also employed to look for other enteroparasites. From 94 children, 4.26% excreted fecal Cryptosporidium oocysts. The infection seemed to vary according to age: 5.08% of patients aged zero to two years old; 33.33% of those aging eight to ten years (P>0.05. Cryptosporidium appeared in November, December and March, during the rainy season. 20.21% of the children harbored at least one enteroparasite different from Cryptosporidium, mainly Giardia intestinalis (12.77%. From Cryptosporidium infected patients, two had only this kind, another harbored Giardia intestinalis; the last one hosted Strongyloides stercoralis.

Covariant framework for a mass monopole as a field structure in general relativity

International Nuclear Information System (INIS)

Schleifer, N.

1980-01-01

We present a covariant framework for what is usually referred to as a mass monopole, by utilizing certain scalar invariants that are functions of the eigenvalues of the Riemann tensor. We thus bridge one of the theoretical gaps in the Einstein-Infeld-Hoffmann (EIH) derivation of the equations of motion of particles from the field equations: the lack of a covariant characterization of those aspects of a particle's structure which influence its motion. We have succeeded in giving a covariant framework for a mass monopole, which is the particle type assumed by EIH in their derivation. This is accomplished by using only the field outside the mass (singularity) to describe its characteristics, thereby conforming to a pure field description of nature. The utility of the framework has been verified by applying it to two physically relevant situations. The first is that of a Kerr particle, and the second is that of one spherically symmetric mass orbiting another. Our framework does indeed correspond to the intuitively expected results. In addition, our novel use of eigenvalues of the Riemann tensor appears to be a possible avenue of approach to the covariant characterization of other particle structure

Gated blood pool studies with a single probe - clinical validity

International Nuclear Information System (INIS)

Loesel, E.; Hoffmann, G.

1981-01-01

The global volume alterations of the heart can be estimated non-invasively by means of the radiocardiographic function analysis developed by Hoffmann and Kleine. Since the failing heart with its functional disturbances demonstrates a pathological volume behaviour under physical exercise, it is possible to use these characteristics to differentiate between the intact heart and the failing heart by registration of the global volume alterations. The gated blood pool technique combined with the registration of the intraventricular pressure pulse by means of a Swan-Ganz flow-directed catheter enables demonstration of ventricular stroke work as a pressure-volume loop (work diagram). Its shape indicates whether the ventricle has to perform mainly pressure work or volume work. Myocardial failure is altering the basic conditions of the heart. The work diagram of the failing heart is significantly different from that of the intact human heart. It is shifted in its pressure-volume coordinates according to an increase of EDV and ESV and the rise of the filling pressure. Case demonstrations reveal the global volume behaviour of the heart under varying conditions: resting and physical exercise, drug influence on the intact and failing heart. (orig.) [de

Solving the relativistic Rankine-Hugoniot condition in the presence of a magnetic field in the astrophysical scenario of a neutron star

International Nuclear Information System (INIS)

Mallick, Ritam

2011-01-01

The Rankine-Hugoniot condition has been solved to study phase transition in an astrophysical scenario mainly in the case of phase transition from a neutron star (NS) to a quark star (QS). The equations of state and temperature play a huge role in determining the nature of the front propagation, which brings about the phase transition in a NS. The shock jump conditions can be solved analytically, but the situation changes drastically by the inclusion of the magnetic field. High magnetic fields, which are always associated with a NS play a huge role in determining the structure and evolution of a NS. So, a magnetic field has been introduced in the shock jump condition in the de Hoffmann-Teller frame. The modified conservation condition for the perpendicular and oblique shocks is obtained in this frame. Numerical solution of the perpendicular shock has been obtained, which shows considerable deviation from the nonmagnetic case. The results show that the magnetic field helps in shock generation. It also indirectly hints at the instability of the matter and thereby the NS for very high magnetic field, implying that NSs can only support a magnetic field of some finite strength.

Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes.

Science.gov (United States)

Drescher, U; Koschate, J; Schiffer, T; Schneider, S; Hoffmann, U

2017-06-01

The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O 2 pulm) and predicted muscular (V˙O 2 musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. Eight healthy individuals performed two PRBS WR protocols implying changes between 30W and 80W and between 30W and 110W. HR and V˙O 2 pulm were measured beat-to-beat and breath-by-breath, respectively. V˙O 2 musc was estimated applying the approach of Hoffmann et al. (Eur J Appl Physiol 113: 1745-1754, 2013) considering a circulatory model for venous return and cross-correlation functions (CCF) for the kinetics analysis. HR and V˙O 2 musc kinetics seem to be independent of WR intensity (p>0.05). V˙O 2 pulm kinetics show prominent differences in the lag of the CCF maximum (39±9s; 31±4s; p<0.05). A mean difference of 14W between the PRBS WR amplitudes impacts venous return significantly, while HR and V˙O 2 musc kinetics remain unchanged. Copyright © 2017 Elsevier B.V. All rights reserved.

Mechanisms of subliminal response priming.

Science.gov (United States)

Kiesel, Andrea; Kunde, Wilfried; Hoffmann, Joachim

2008-07-15

Subliminal response priming has been considered to operate on several stages, e.g. perceptual, central or motor stages might be affected. While primes' impact on target perception has been clearly demonstrated, semantic response priming recently has been thrown into doubt (e.g. Klinger, Burton, & Pitts, 2000). Finally, LRP studies have revealed that subliminal primes evoke motor processes. Yet, the premises for such prime-evoked motor activation are not settled. A transfer of priming to stimuli that have never been presented as targets appears particularly interesting because it suggests a level of processing that goes beyond a reactivation of previously acquired S-R links. Yet, such transfer has not always withstood empirical testing. To account for these contradictory results, we proposed a two-process model (Kunde, Kiesel, & Hoffmann, 2003): First, participants build up expectations regarding imperative stimuli for the required responses according to experience and/or instructions. Second, stimuli that match these "action triggers" directly activate the corresponding motor responses irrespective of their conscious identification. In line with these assumptions, recent studies revealed that non-target primes induce priming when they fit the current task intentions and when they are expected in the experimental setting.

Environmental impact of almond crop in strong slope with two vegetable covers: bush and leguminous; Impacto en el medio ambiente del cultivo de almendros en fuertes pendientes con dos cubiertas vegetales: Matorral y Leguminosa

Energy Technology Data Exchange (ETDEWEB)

Carceles Rodriguez, B.; Francia Martinez, J. R.; Martinez Raya, A.

2009-07-01

Soil erosion is one of the main physical processes of land degradation in Spain. Several studies in the Mediterranean environment have demonstrated the positive effect of vegetation covers on the reduction of water erosion and their indirect improvement of the soil physical and chemical properties, essentially by the incorporation of organic matter. Sol loss and surface runoff patterns over a four-year period were monitors in erosion plots from hill slope with two different cover-crop strips: (1) non-tillage with leguminous (Lens esculenta Moench) and (2) non-tillage with and a mixture of autochthonous thymes (Thymus baeticus Boiss. ex Lacaita, Thymus capitatus (L) Hoffmanns and Link., Thymus vulgaris L.) of 3 m with, in Lanjaron (Granada) on the south flank of the Sierra Nevada of southeast Spain. The erosion plots were located on the hill slope at 35% incline, at 580 m in altitude and with 144 m{sup 2} (24 m x 6 m) in area. the area selected for the experiment is the part of the rainfed orchard given entirely with almond (Prunus amygdalus Basch cv. Desmayo Largueta) trees, the planting gird were 6 x 7 m. (Author) 10 refs.

Essential oil chemical composition and antifungal effects on Sclerotium cepivorum of Thymus capitatus wild populations from Calabria, southern Italy

Directory of Open Access Journals (Sweden)

Mariateresa Russo

2013-04-01

Full Text Available The paper reports the qualitative and quantitative composition and its antifungal activities of Thymus capitatus (L. Hoffmanns. & Link, Lamiaceae, essential oils isolated by hydrodistillation from the aerial parts of plants collected in Calabria, Southern Italy. The essential oils of 22 samples were analysed by GC-Flame ionization detection and GC/MS. A total of sixty five compounds were identified. Phenols were present in highest percentage (average: 79,03%. Carvacrol was the main component (81,52%-78,40% in all samples, confirming that T. capitatus is a carvacrol chemotype, according to literature data for this species. This essential oil was also characterized by high level of biogenetic precursor of the phenols: p-cimene (4,98%, γ-terpinene (3,13% and by β-cariophyllene, were the most abundant sesquiterpene hydrocarbons. Antifungal activity against Sclerotium cepivorum Berk., a soil born fungus, was tested. At the concentration of 250 ppm there was no development of fungal mycelium. To our knowledge, studies have never been conducted on Calabria wild populations of T. capitatus essential oil nor were conducted studies on parasitic fungi of specific interest for crops such as Sclerotium cepivorum.

An intelligent utilization of the facettes of IT outsourcing - About costs and use of outsourcing in the branch of energy economy; Facetten des IT-Outsourcings intelligent nutzen - Ueber Kosten und Nutzen des Outsourcings in der Engergiewirtschaftsbranche

Energy Technology Data Exchange (ETDEWEB)

Koehler-Schute, Christiana (ed.)

2008-07-01

The restructuring of the German energy economy is connected with an enormous expenditure of know-how and substantial financial investments. Under this aspect, the book under consideration wants to suggest decision-makers in companies to include options to the outsourcing into their strategic considerations. Additionally, information for their decision preparation is to give to the decision-makers. The book contains the following contributions: (a) Information technology (IT) as business drivers in public utilities of the future (Holger Bonk, Wolfgang Herbers); (b) Smart outsourcing as creation of value factor (Ulrich Czubayko, Anke Schaefer); (c) From the web service to the full outsourcing in the energy market - an overview for decision making Make-or-Buy (Alexander-Ivo Franz); (d) Outsourcing in the energy industry from view of Siemens IT Solutions and services (Josef Kapp); (e) Consumption accounting, energy data management, customer data administration and data exchange from one hand: A standardised ASP solution offers data management from one hand (Mario Strauss, Kristina Seifert); (f) Smart of Metering systems, AMM and reading of the meter successfully outsourcen (Ralf Hoffmann, Simon Loeffler); (g) Contract design with the outsourcing with special consideration of the BPO and IT-outsourcing (Thomas Soebbing).

General relativistic continuum mechanics and the post-Newtonian equations of motion

International Nuclear Information System (INIS)

Morrill, T.H.

1991-01-01

Aspects are examined of general relativistic continuum mechanics. Perfectly elastic materials are dealt with but not exclusively. The derivation of their equations of motion is emphasized, in the post-Newtonian approximation. A reformulation is presented based on the tetrad formalism, of Carter and Quintana's theory of general relativistic elastic continua. A field Lagrangian is derived describing perfect material media; show that the usual covariant conservations law for perfectly elastic media is fully equivalent to the Euler-Lagrange equations describing these same media; and further show that the equations of motion for such materials follow directly from Einstein's field equations. In addition, a version of this principle shows that the local mass density in curved space-time partially depends on the amount and distribution of mass energy in the entire universe and is related to the mass density that would occur if space-time were flat. The total Lagrangian was also expanded in an EIH (Einstein, Infeld, Hoffmann) series to obtain a total post-Newtonian Lagrangian. The results agree with those found by solving Einstein's equations for the metric coefficients and by deriving the post-Newtonian equations of motion from the covariant conservation law

La poética del forastero en El zorro de arriba y el zorro de abajo, de José María Arguedas

Directory of Open Access Journals (Sweden)

Mónica Bernabé

2014-06-01

Full Text Available Leídos en el marco que impone la totalidad de los textos reunidos bajo el nombre de José María Arguedas, los diarios de El zorro... constituyen un fragmento dentro de un espacio autobiográfico mayor en el que se despliegan las variaciones en la figuración de la persona del autor. Ellas van desde el sesgo autobiográfico de algunos personajes de sus novelas hasta su autorrepresentación en ensayos etnográficos y folclóricos; también incluyen las cartas a la doctora Hoffmann y a John Murra además de sus “confesiones” en el Primer Encuentro de Narradores Peruanos del año 1965 en Arequipa. Más aún, si desistimos del régimen de verdad –y el estatuto de “autor-idad” que suele asumir para la crítica literaria la palabra del autor– podríamos confrontar los diversos relatos que establecen un espacio autobiográfico para trazar las marcas de las diferencias en los modos de autofiguración de José María Arguedas.

Nickel-based materials and high-alloy, special stainless steels. 2. new rev. and enl. ed.

International Nuclear Information System (INIS)

Heubner, U.; Brill, U.; Hoffmann, T.; Jasner, M.; Kirchheiner, R.; Koecher, R.; Richter, H.; Rockel, M.; White, F.

1993-01-01

The book is intended as a source of information on nickel-based materials and special stainless steels and apart from the up-to-date materials data presents information on recent developments and knowledge gained, so that it may be a valuable aid to materials engineers looking for cost-effective resolutions of their materials problems in the chemical process industry, power plant operation, and high-temperature applications. The book presents eight individual contributions entitled as follows: (1) Nickel-base alloys and high-alloy, special stainless steels. - Materials survey and data sheets (Ulrich Heubner). (2) Corrosion of nickel-base alloys and special stainless steels (Manfred Rockel). (3) Welding of nickel-base alloys and high-alloy, special stainless steels (Theo Hoffmann). (4) High-temperature resistant materials (Ulrich Brill). (5) Application and processing of nickel-base materials in the chemical process industry and in pollution abatement equipment (Reiner Koecher). (6) Selected examples of applications of nickel-base materials in chemical plant (Manfred Jasner, Frederick White). (7) Applications of nickel-base alloys and special stainless steels in power plant. (8) The use of nickel-base alloys and stainless steels in pollution abatement processes (R. Kirchheiner). (orig./MM). 151 figs., 226 refs [de

Environmental impact of almond crop in strong slope with two vegetable covers: bush and leguminous

International Nuclear Information System (INIS)

Carceles Rodriguez, B.; Francia Martinez, J. R.; Martinez Raya, A.

2009-01-01

Soil erosion is one of the main physical processes of land degradation in Spain. Several studies in the Mediterranean environment have demonstrated the positive effect of vegetation covers on the reduction of water erosion and their indirect improvement of the soil physical and chemical properties, essentially by the incorporation of organic matter. Sol loss and surface runoff patterns over a four-year period were monitors in erosion plots from hill slope with two different cover-crop strips: (1) non-tillage with leguminous (Lens esculenta Moench) and (2) non-tillage with and a mixture of autochthonous thymes (Thymus baeticus Boiss. ex Lacaita, Thymus capitatus (L) Hoffmanns and Link., Thymus vulgaris L.) of 3 m with, in Lanjaron (Granada) on the south flank of the Sierra Nevada of southeast Spain. The erosion plots were located on the hill slope at 35% incline, at 580 m in altitude and with 144 m 2 (24 m x 6 m) in area. the area selected for the experiment is the part of the rainfed orchard given entirely with almond (Prunus amygdalus Basch cv. Desmayo Largueta) trees, the planting gird were 6 x 7 m. (Author) 10 refs.

Enteropatógenos relacionados à diarréia em pacientes HIV que fazem uso de terapia anti-retroviral Enteropathogens relating to diarrhea in HIV patients on antiretroviral therapy

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Áurea Regina Telles Pupulin

2009-10-01

Full Text Available A etiologia do processo diarréico na AIDS pode ser causada por vírus, bactérias, fungos, protozoários e helmintos, assim como pelo próprio HIV. Este trabalho avaliou enteropatogenos relacionados à diarréia em pacientes HIV que fazem uso de terapia anti-retroviral. Os métodos parasitológicos utilizados foram Faust, Hoffmann e Kinyoun. O isolamento e cultura dos fungos foram realizados conforme metodologia recomendada por NCCLS M27-A standard. A identificação das espécies de leveduras foi realizada através da reação em cadeia da polimerase. O isolamento de bactérias, foi feito em agar Mac Conkey e agar SS, a identificação das espécies através do Enterokit B (Probac do Brasil e métodos bioquímicos. Foram avaliados 49 pacientes, 44,9% apresentaram enteroparasitas, 48,1% Candida sp com 61,5% Candida albicans, 7,6% Candida sp e 30,7% Candida não- albicans. Foram isoladas bactérias de 72% dos pacientes, 49% Escherichia coli, 13% Salmonella parathyphi, Klebsiella sp ou Proteus e 6% Citrobacter freundii ou Yersinia sp. Houve alta prevalência de Candida sp nos pacientes HIV com diarréia e foram isoladas espécies não albicans cuja presença pode ser entendida como cúmplice ou causa da infecção.The etiology of the diarrheic process in AIDS may be caused by viruses, bacteria, fungi, protozoa or helminths, as well as HIV itself. This study evaluated enteropathogens relating to diarrhea in HIV patients who were on antiretroviral therapy. The parasitological methods used were Faust, Hoffmann and Kinyoun. Isolation and culturing of fungi were carried out in accordance with the methodology recommended by the NCCLS M27-A standard. The yeast species were identified using the polymerase chain reaction (PCR. Bacteria were isolated on MacConkey and SS agar and the species were identified using Enterokit B (Probac do Brasil and biochemical methods. Forty-nine patients were evaluated: 44.89% presented enteroparasites and 48.1% presented

Development and application of denuder sampling techniques with in situ derivatization for the determination of hydrogenbromide in volcanic plumes

Science.gov (United States)

Gutmann, Alexandra; Rüdiger, Julian; Hoffmann, Thorsten

2016-04-01

The composition of gases in volcanic plumes shifts with subsurface processes inside volcanoes. For monitoring volcanic activity by studying volcanic plumes it is essential to understand the chemical reactions inside the volcanic plume (Bobrowski and Platt, 2013). Measurements of BrO/SO2-ratio already enable insights into magmatic processes (Bobrowski and Giuffrida, 2012). Both, BrO and SO2, are measurable by Remote Sensing Techniques at a safe distance. Models suggest not a direct emission of BrO but formation due to photochemical and multiphase reactions in the gas and particle phase. These model presume HBr as first emitted species (Gerlach, 2004). So HBr is an important connecting link between easily measurable BrO/SO2-ratios and conclusions on a volcanic system. It is of high importance to know if there is a variation in the amount of HBr transformed into BrO and to gain knowledge on the factor of its dependence. Apart from depletion of surrounded ozone also decreasing or depletion of emitted HBr or even HCl could be responsible for the shift (Bobrowski and Giuffrida, 2012). Knowledge about complex processes in volcanic plumes will simplify interpretation and predictions. In this study, first applications of coated gas diffusion denuder (similar to Huang and Hoffmann, 2008) to derivatize gaseous HBr were successful. Due to the lack of adequate remote sensing techniques an in situ method was developed and will be presented in detail. The epoxide of oleic acid was determined as a suitable derivatization agent. The reaction with HBr gives 10-bromo-9-hydroxyoctadecanoic acid. Other hydrogenhalogens give corresponding products. Derivatized analytes were removed from denuder by solvent elution and subsequent analysed with gas chromatography-mass spectrometry. A limit of quantification below 1 ng was achieved. The method was applied on volcanic gas plumes at Mt. Etna in Italy in July and August 2015. The results showed HBr in higher ppt-range. These first proof

An Unusual Cause of Dementia: Essential Diagnostic Elements of Corticobasal Degeneration—A Case Report and Review of the Literature

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F. Mastrolilli

2011-01-01

Full Text Available Corticobasal degeneration (CBD is an uncommon, sporadic, neurodegenerative disorder of mid- to late-adult life. We describe a further example of the pathologic heterogeneity of this condition. A 71-year-old woman initially presented dysarthria, clumsiness, progressive asymmetric bradykinesia, and rigidity in left arm. Rigidity gradually involved ipsilateral leg; postural instability with falls, blepharospasm, and dysphagia subsequently developed. She has been previously diagnosed as unresponsive Parkinson's Disease. At our clinical examination, she presented left upper-arm-fixed-dystonia, spasticity in left lower limb and pyramidal signs (Babinski and Hoffmann. Brain MRI showed asymmetric cortical atrophy in the right frontotemporal cortex. Neuropsychological examination showed an impairment in visuospatial functioning, frontal-executive dysfunction, and hemineglect. This case demonstrates that association of asymmetrical focal cortical and subcortical features remains the clinical hallmark of this condition. There are no absolute markers for the clinical diagnosis that is complicated by the variability of presentation involving also cognitive symptoms that are reviewed in the paper. Despite the difficulty of diagnosing CBD, somatosensory evoked potentials, motor evoked potentials, long latency reflexes, and correlations between results on electroencephalography (EEG and electromyography (EMG provide further support for a CBD diagnosis. These techniques are also used to identify neurophysiological correlates of the neurological signs of the disease.

Transparent thermal insulation for a fabrication hall of LHB, Salzgitter; Transparent gedaemmte Fertigungshalle bei LHB in Salzgitter

Energy Technology Data Exchange (ETDEWEB)

Galetzky, A. [Linke-Hofmann-Busch Waggon - Fahrzeug - Maschinen GmbH, Salzgitter (Germany); Goller, M. [Fraunhofer-Institut fuer Solare Energiesysteme (ISE), Freiburg im Breisgau (Germany)

1997-12-31

Many industrial workshops in Germany were erected during the 40s and 50s, especially at the beginning of the economic boom. After more than 40 years, these facilities are in need of structural and production-technical modernization. A case in point is the carriage fabrication workshop of the Salzgitter-based company Linke-Hoffmann-Busch. The characteristic features of this type of building are large glazed areas, free uncontrolled ventilation and substantial height. Opportunities for energy-oriented and light-technical modernization are demonstrated at this Salzgitter workshop in exemplary form, the emphasis being on the use of solar energy components and, particularly, transparent thermal insulation. (orig.) [Deutsch] In der Bundesrepublik Deutschland gibt es viele Produktionshallen, die in den vierziger und fuenfziger Jahren, insbesondere zu Beginn des wirtschaftlichen Aufschwungs, errichtet wurden. Diese Hallen sind nach ueber vierzig Jahren sowohl aus baulichen als auch produktionstechnischen Gruenden sanierungsbeduerftig. Die Halle 1, Waggonneubau, der Linke-Hofmann-Busch GmbH in Salzgitter ist ein typischer Vertreter dieser Art von Hallen. Sie zeichnen sich durch grosse Verglasungsflaechen, freie unkontrollierte Lueftung und relativ grosse Bauhoehe aus. Exemplarisch werden an dieser Halle Moeglichkeiten einer energetischen und lichttechnischen Sanierung aufgezeigt, wobei der Einsatz von Solarenergiekomponenten und insbesondere der Transparenten Waermedaemmung besondere Beruecksichtigung erfaehrt. (orig.)

Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat

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Kévin Buffenoir

2013-01-01

Full Text Available Aims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H reflex to a greater extent than the direct motor (M response induced by electrical stimulation, but the timecourse of these responses has not been investigated. Methods. An animal (rat model of the effects of lidocaine on M and H responses was therefore developed to assess this time course. M and H responses were recorded in 18 adult rats before and after application of lidocaine to the sciatic nerve. Results. Two to five minutes after lidocaine injection, M responses were markedly reduced (mean reduction of 44% and H reflexes were completely abolished. Changes were observed more rapidly for the H reflex. The effects of lidocaine then persisted for 100 minutes. The effect of lidocaine was therefore more prolonged on the H reflex than on the M response. Conclusion. This study confirms that lidocaine blocks not only alpha motoneurons but also Ia afferent fibres responsible for the H reflex. The authors describe, for the first time, the detailed time course of the effect of lidocaine on direct or reflex activation of motoneurons in the rat.

Aquatic environmental risk assessment for human use of the old antibiotic sulfamethoxazole in Europe.

Science.gov (United States)

Straub, Jürg Oliver

2016-04-01

Sulfamethoxazole (SMX) is an old sulfonamide antibiotic that was launched first in combination with trimethoprim in 1969 by F.Hoffmann-La Roche. Although sales figures for SMX have been declining over the past 20 yr, the compound is still widely used; moreover, many measured environmental concentrations (MECs) are available from Europe, the United States, Asia, Australia, and Africa. To assess aquatic risks of SMX in Europe, the exposure of European surface waters was predicted based on actual sales figures from IMS Health, incorporating environmental fate data on one side, and based on collated MECs representing more than 5500 single measurements in Europe on the other. Environmental effects were assessed using chronic and subchronic ecotoxicity data for 16 groups of aquatic organisms, from periphyton communities to cyanobacteria, algae, higher plants, various invertebrates, and vertebrates. Predicted no-effect concentrations (PNECs) were derived using both deterministic and probabilistic methodology. The predicted environmental concentration (PEC)/PNEC and MEC/PNEC comparisons overall showed no appreciable risk, except in a low incidence (risk characterization ratios greater than 1. The PNECs derived in the present study can be used to extend aquatic environmental risk assessment for SMX to other continents. No risk appears for indirect human exposure to SMX via the environment. © 2015 SETAC.

Impact of water supply, domiciliary water reservoirs and sewage on faeco-orally transmitted parasitic diseases in children residing in poor areas in Juiz de Fora, Brazil.

Science.gov (United States)

Teixeira, J C; Heller, L

2006-08-01

The objectives of this study were to characterize faeco-orally transmitted parasitic diseases and to identify the factors associated with these diseases, with emphasis on environmental factors, in children ranging from 1 up to 5 years old residing in substandard settlement areas. A population-based cross-sectional epidemiological design was used in a non-random selection of 29 out of the 78 substandard settlement areas in the municipality of Juiz de Fora, Brazil. A sample of 753 children were assessed from the target population consisting of all children of the appropriate age range residing in the selected areas. Data were collected by means of domiciliary interviews with their mothers or with the person responsible for them. The Hoffmann-Pons-Janer method was used in the parasitological examination of faeces. Binary logistic regression models were used to identify the factors associated with the diseases. A total of 319 sample children presented faeco-orally transmitted parasitic diseases. The factors associated with these parasitic diseases included the children's age, family income, number of dwellers in the domicile, consumption of water from shallow wells, consumption of water from natural sources, absence of covered domiciliary water reservoirs, and the presence of sewage flowing in the street.

The Composition of Cigarette Smoke. An Historical Perspective of Several Polycyclic Aromatic Hydrocarbons

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Rodgman A

2014-12-01

Full Text Available Because of the significant advancements in fractionation, analytical, and characterization technologies since the early 1960s, hundreds of components of complex mixtures have been accurately characterized without the necessity of actually isolating the individual component. This has been particularly true in the case of the complex mixtures tobacco and tobacco smoke. Herein, an historical account of a mid-1950 situation concerning polycyclic aromatic hydrocarbons (PAHs in cigarette smoke is presented. While the number of PAHs identified in tobacco smoke has escalated from the initial PAH, azulene, identified in 1947 to almost 100 PAHs identified by late 1963 to more than 500 PAHs identified by the late 1970s, the number of PAHs isolated individually and characterized by several of the so-called classical chemical means (melting point, mixture melting point, derivative preparation and properties in the mid-1950s and since is relatively few, 14 in all. They were among 44 PAHs identified in cigarette mainstream smoke and included the following PAHs ranging from bicyclic to pentacyclic: Acenaphthylene, 1,2-dihydroacenaphthylene, anthracene, benz[a]anthracene, benzo[a]pyrene, chrysene, dibenz[a, h]anthracene, fluoranthene, 9H-fluorene, naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, phenanthrene, and pyrene. One of them, benzo[a]pyrene, was similarly characterized in another study in 1959 by Hoffmann.

The methodological proposal of photography as a discharger of the trigger of memory: application to Telêmaco Borba s history (1950-1969

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Juliana de Oliveira Teixeira

2014-07-01

Full Text Available This work has the objectives of testing and systematizing the methodological proposal of photography as a discharger of the trigger of memory, a technique that combines photographic images with oral history. The method, developed by the group Communication and History of Universidade Estadual de Londrina, was formalized in the dissertation of Maria Luisa Hoffmann (2010 and, since then, it has been applied to cities with recent histories. To do a relevant test in this dissertation, Telêmaco Borba(PR was chosen as field of study, and the precepts of empiricism in communication were respected, following the ideas of Maria Immacolata Vassallo Lopes (2010 and Luiz Claudio Martino (2010. The application of the method was also based theoretically, using as references the works of Jacques Le Goff (2003, Ecléa Bosi (2009 and Boris Kossoy (2009. During the empirical process, nine pioneers of Telêmaco Borba were submitted to the methodological proposal, using 17 old photographs of the city. Roughly, the results of the test show that the technique, when applied with the epistemological criteria of science, becomes an efficient empirical tool, capable of bringing new data and information to the studies of memory and to the history of the studied cities.

Emicizumab Prophylaxis in Hemophilia A with Inhibitors.

Science.gov (United States)

Oldenburg, Johannes; Mahlangu, Johnny N; Kim, Benjamin; Schmitt, Christophe; Callaghan, Michael U; Young, Guy; Santagostino, Elena; Kruse-Jarres, Rebecca; Negrier, Claude; Kessler, Craig; Valente, Nancy; Asikanius, Elina; Levy, Gallia G; Windyga, Jerzy; Shima, Midori

2017-08-31

Emicizumab (ACE910) bridges activated factor IX and factor X to restore the function of activated factor VIII, which is deficient in persons with hemophilia A. This phase 3, multicenter trial assessed once-weekly subcutaneous emicizumab prophylaxis in persons with hemophilia A with factor VIII inhibitors. We enrolled participants who were 12 years of age or older. Those who had previously received episodic treatment with bypassing agents were randomly assigned in a 2:1 ratio to emicizumab prophylaxis (group A) or no prophylaxis (group B). The primary end point was the difference in bleeding rates between group A and group B. Participants who had previously received prophylactic treatment with bypassing agents received emicizumab prophylaxis in group C. A total of 109 male participants with hemophilia A with inhibitors were enrolled. The annualized bleeding rate was 2.9 events (95% confidence interval [CI], 1.7 to 5.0) among participants who were randomly assigned to emicizumab prophylaxis (group A, 35 participants) versus 23.3 events (95% CI, 12.3 to 43.9) among those assigned to no prophylaxis (group B, 18 participants), representing a significant difference of 87% in favor of emicizumab prophylaxis (Phemophilia A with inhibitors. (Funded by F. Hoffmann-La Roche and Chugai Pharmaceutical; HAVEN 1 ClinicalTrials.gov number, NCT02622321 .).

Restricted Hartree Fock using complex-valued orbitals: A long-known but neglected tool in electronic structure theory

Energy Technology Data Exchange (ETDEWEB)

Small, David W.; Sundstrom, Eric J.; Head-Gordon, Martin [Department of Chemistry, University of California, Berkeley, California 94720, USA and Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States)

2015-01-14

Restricted Hartree Fock using complex-valued orbitals (cRHF) is studied. We introduce an orbital pairing theorem, with which we obtain a concise connection between cRHF and real-valued RHF, and use it to uncover the close relationship between cRHF, unrestricted Hartree Fock, and generalized valence bond perfect pairing. This enables an intuition for cRHF, contrasting with the generally unintuitive nature of complex orbitals. We also describe an efficient computer implementation of cRHF and its corresponding stability analysis. By applying cRHF to the Be + H{sub 2} insertion reaction, a Woodward-Hoffmann violating reaction, and a symmetry-driven conical intersection, we demonstrate in genuine molecular systems that cRHF is capable of removing certain potential energy surface singularities that plague real-valued RHF and related methods. This complements earlier work that showed this capability in a model system. We also describe how cRHF is the preferred RHF method for certain radicaloid systems like singlet oxygen and antiaromatic molecules. For singlet O{sub 2}, we show that standard methods fail even at the equilibrium geometry. An implication of this work is that, regardless of their individual efficacies, cRHF solutions to the HF equations are fairly commonplace.

O hipertexto e o estranho: causas e efeitos

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Everton Vinicius de Santa

2010-07-01

Full Text Available Segundo Barthes, o texto ideal é aquele que se apresenta em redes múltiplas e que se entrelaça, sem comprometer sua estrutura. Redes ou nós que fazem com que esse texto ofereça um universo de significantes e significados, ou seja, não tem início, é reversível, possui diversas entradas e isso se choca com a noção tradicional de práticas de leitura e escrita linear. Nesse sentido, nosso objetivo é demonstrar como o hipertexto causa "estranheza" partindo do conceito de “estranho” apontado por Freud em seu artigo Das Unheimlich (1919, a fim de que possamos compreender como essa relação obra/leitor vem sendo alterada e provocando sensações de dinamicidade distintas da inércia do papel, como observamos em O Jogo da Amarelinha (1963, de Julio Cortázar, e em textos de temática fantástica, como em E.T.A. Hoffmann e Edgar Allan Poe, não no sentido do assustador, mas do provocativo, do foregrounding que gera causas e efeitos significantes nas práticas literárias digitais conectadas ao ciberespaço.

Dispersion of Functionalized Silica Micro- and Nanoparticles into Poly(nonamethylene Azelate by Ultrasonic Micro-Molding

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Angélica Díaz

2015-11-01

Full Text Available Ultrasound micro-molding technology has proved useful in processing biodegradable polymers with minimum material loss. This makes this technology particularly suitable for the production of biomedical microdevices. The use of silica (SiO2 nanoparticles is also interesting because of advantages like low cost and enhancement of final properties. Evaluation of the capacity to create a homogeneous dispersion of particles is crucial. Specifically, this feature was explored taking into account micro- and nano-sized silica particles and a biodegradable polyester derived from 1,9-nonanodiol and azelaic acid as a matrix. Results demonstrated that composites could be obtained with up to 6 wt. % of silica and that no degradation occurred even if particles were functionalized with a compatibilizer like (3-aminopropyl triethoxysilane. Incorporation of nanoparticles should have a great influence on properties. Specifically, the effect on crystallization was evaluated by calorimetric and optical microscopy analyses. The overall crystallization rate was enhanced upon addition of functionalized silica nanospheres, even at the low percentage of 3 wt. %. This increase was mainly due to the ability of nanoparticles to act as heterogeneous nuclei during crystallization. However, the enhancement of the secondary nucleation process also played a significant role, as demonstrated by Lauritzen and Hoffmann analysis.

Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila.

Science.gov (United States)

Romey-Glüsing, Renja; Li, Yang; Hoffmann, Julia; von Frieling, Jakob; Knop, Mirjam; Pfefferkorn, Roxana; Bruchhaus, Iris; Fink, Christine; Roeder, Thomas

2018-04-01

Nutritional interventions such as caloric and dietary restriction increase lifespan in various animal models. To identify alternative and less demanding nutritional interventions that extend lifespan, we subjected fruit flies ( Drosophila melanogaster) to weekly nutritional regimens that involved alternating a conventional diet with dietary restriction. Short periods of dietary restriction (up to 2 d) followed by longer periods of a conventional diet yielded minimal increases in lifespan. We found that 3 or more days of contiguous dietary restriction (DR) was necessary to yield a lifespan extension similar to that observed with persistent DR. Female flies were more responsive to these interventions than males. Physiologic changes known to be associated with prolonged DR, such as reduced metabolic rates, showed the same time course as lifespan extension. Moreover, concurrent transcriptional changes indicative of reduced insulin signaling were identified with DR. These physiologic and transcriptional changes were sustained, as they were detectable several days after switching to conventional diets. Taken together, diets with longer periods of DR extended lifespan concurrently with physiologic and transcriptional changes that may underlie this increase in lifespan.-Romey-Glüsing, R., Li, Y., Hoffmann, J., von Frieling, J., Knop, M., Pfefferkorn, R., Bruchhaus, I., Fink, C., Roeder, T. Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila.

Contribution to the knowledge of Saprinus Erichson, 1834 of forensic relevance from Lebanon (Coleoptera, Histeridae)

Science.gov (United States)

Shayya, Salman; Dégallier, Nicolas; Nel, André; Azar, Dany; Lackner, Tomáš

2018-01-01

Abstract Many histerid beetles are necrophilous on carrion during both active and advanced stages of decomposition. In this study, 13 species of Saprinus were recorded on carrion from Lebanon, containing eight that are new for the Lebanese fauna. The following Saprinus species are newly recorded from Lebanon: 1) Saprinus (S.) caerulescens caerulescens (Hoffmann, 1803); 2) S. (S.) calatravensis Fuente, 1899; 3) S. (S.) chalcites (Illiger, 1807); 4) S. (S.) godet (Brullé, 1832); 5) S. (S.) maculatus (P. Rossi, 1792); 6) S. (S.) strigil Marseul, 1855; 7) S. (S.) submarginatus J. Sahlberg, 1913; and 8) S. (S.) tenuistrius sparsutus Solsky, 1876. The peak activity was recorded, key for the species is provided, and habitus images and male genitalia are illustrated in order to facilitate their taxonomic identifications. Saprinus species are diverse and common on animal carcass; they were likewise collected from a human cadaver in Lebanon. Preliminary comments on biology and distribution of the studied species are given. Our paper represents the first faunistic study on Histeridae from Lebanon. A rigorous research program regarding the biology of Saprinus in Lebanon and the neighbouring countries would greatly improve the knowledge of the diversity, activity, and possible forensic value of Saprinus. PMID:29670426

Basic legal provisions concerning the activities of industrial security personnel

International Nuclear Information System (INIS)

Eberstein, H.H.

1980-01-01

The author confines himself to sabotage and espionage. Necessary counter-measures are determined by the respective type of activities. Sect. 618 of the German Civil Code and Sect. 120 a of the Industrial Code give basic legal provisions for the protection of industrial personnel. The legal position held by owner or occupant forms the legal basis for 'vulnerable point protection'. The owner's rights are assigned to the industrial police and are exercised in correspondence with the service or employment contract set up according to Sect. 611 and the following sections of the German Civil Code. Outside guards work according to the performance contract given int the Sections 675, 611, 631 of the German Civil Code. The security personnel has the common right of self-help: self-defence, civil rights concerning the state of national emergency and self-defence under criminal law, rights derived from ownership and property. The author critically argues views held by Mr. Hoffmann-Riem who thinks that police powers have been assigned to private persons. He definitely answers in the negative to the execution of, or encroachment on, sovereign (police) powers by industrial security personnel. A special legal regulation is not necessary, since private protection in form of professional selfdefence is admissible under the law in force. (HSCH) [de

Eco-innovation, international trade, WTO and climate: Key issues for an ecological industrial policy. Documentation of a workshop on March 12, 2008

Energy Technology Data Exchange (ETDEWEB)

Hoppe, Jutta; Kahlenborn, Walter [Adelphi Research, Berlin (Germany); Gather, Corinna (eds.) [Umweltbundesamt, Dessau (Germany)

2009-01-15

Within the meeting of the German Federal Environment Agency (Dessau, Federal Republic of Germany) and the German Federal Ministry for the Environment, Nature Conservation and Natural Safety (Berlin, Federal Republic of Germany) at 12th March, 2008, the following reports were held: (a) Trade Policy and Climate Change - An overview from the perspective of an ecological industrial policy (Jutta Hoppe et al.); (b) Kyoto, Post-Kyoto and the WTO (Malena Sell); (c) Climate change, trade and competitiveness (Aaron Cosby, John Drexhage); (d) Unilateral climate policy and implications for trade policy (Susanne Droege); (e) Trade in environmental goods and services relevant to climate-change mitigation: Opportunities and challenges for new industries in the European Union (Mahesh Sugathan); (f) The relevance of WTO activities and rules in the climate change debate (Ludivine Tamiotti); (g) Like-products, energy standards and labelling (Roland Ismer); (h) EC Trade policy and climate challenges: An overview of EC trade policy approaches to climate change (Ditte Juul-Joergensen); (i) Opportunities and constraints for an integrated European climate and trade policy (Ulrich Hoffmann); (j) Climate change, eco-innovation, and EU trade policy: a critical assessment (Daniel Mittler); (k) Resume: Key Issues for an Ecological Industrial policy (Jutta Hoppe, Walter Kahlenborn).

Electronic structure of PrBa2Cu3O7: A local-spin-density approximation with on-site Coulomb interaction

International Nuclear Information System (INIS)

Biagini, M.; Calandra, C.; Ossicini, S.

1995-01-01

Electronic structure calculations based on the local-spin-density approximation (LSDA) fail to reproduce the antiferromagnetic ground state of PrBa 2 Cu 3 O 7 (PBCO). We have performed linear muffin-tin orbital--atomic sphere approximation calculations, based on the local-spin-density approximation with on-site Coulomb correlation applied to Cu(1) and Cu(2) 3d states. We have found that inclusion of the on-site Coulomb interaction modifies qualitatively the electronic structure of PBCO with respect to the LSDA results, and gives Cu spin moments in good agreement with the experimental values. The Cu(2) upper Hubbard band lies about 1 eV above the Fermi energy, indicating a Cu II oxidation state. On the other hand, the Cu(1) upper Hubbard band is located across the Fermi level, which implies an intermediate oxidation state for the Cu(1) ion, between Cu I and Cu II . The metallic character of the CuO chains is preserved, in agreement with optical reflectivity [K. Takenaka et al., Phys. Rev. B 46, 5833 (1992)] and positron annihilation experiments [L. Hoffmann et al., Phys. Rev. Lett. 71, 4047 (1993)]. These results support the view of an extrinsic origin of the insulating character of PrBa 2 Cu 3 O 7

Validation of an HPLC method for the determination of fleroxacin and its photo-degradation products in pharmaceutical forms.

Science.gov (United States)

Djurdjevic, Predrag; Laban, Aleksandra; Jelikic-Stankov, Milena

2004-01-01

HPLC determination of fleroxacin in dosage forms was carried out using either reversed-phase column YMC pack ODS-AQ or Supelco LC Hisep shielded hydrophobic phase column, with UV detection at 280 nm. The mobile phase for ODS column consisted of 50:50:0.5 v/v/v and for Hisep column 15:85:0.5 v/v/v acetonitrile-water-triethylamine. The pH of the mobile phase was adjusted to 6.30 for ODS column and to 6.85 for Hisep column, with H3PO4. Linear response was obtained in the concentration range of fleroxacin between 0.01 and 1.30 micrograms/mL. Detection limit was 4.8 ng/mL. Recovery test in the determination of fleroxacin in "Quinodis" tablets (Hoffmann La Roche, nominal mass 400 or 200 mg) was 98-101% for both columns. The effect of the composition and pH of the mobile phase on spectra, retention time and dissociation constants of fleroxacin was discussed. The proposed method could be also used for separation of the photo-degradation products of fleroxacin. Ten degradation products were separated on the ODS-AQ column, thus confirming the suitability of the proposed method for stability study of fleroxacin in pharmaceuticals.

The role of testing realism on experimentally obtained stereotype strength.

Science.gov (United States)

Hoffmann, Errol R; Whitfield, Richard C

2011-01-01

It has been shown (Hoffmann 2009) that pencil-and-paper tests, when used to determine stereotype strength, may yield data quite different to that obtained from hardware tests. The purpose of this research was to determine the level of realism required in order to have stereotypes that are consistent with real-world values. It is surprising that there does not appear to be any published research addressing this problem; all previous researches have considered either paper/pencil or hardware tests or sometimes both, but no level of simulation in between these techniques. In order to determine the effect of level of testing realism, a specific example was chosen to test, that of water tap operation stereotypes. Tests used verbal questioning, photographs of tap arrangements, a partial hardware arrangement and finally a full hardware setup. The results of these four levels of realism were very different and illustrated that, only with a full realistic simulation, did participants respond as might be expected in a real-world environment, illustrating the importance of testing realism when determining population stereotypes. This result has strong implications for product designers when selecting appropriate layouts of displays and controls and the linkages relating these. Copyright © 2010 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Frequency of gastrointestinal parasites in dogs and cats of Londrina, PR, focusing on public health

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Fernanda Pinto Ferreira

2014-02-01

Full Text Available The aim of this study was to determine the frequency of gastrointestinal parasites in dogs and cats of Londrina, Paraná. A survey of the results of fecal examinations, the technique of Faust, Willis, Hoffmann and / or direct examination, performed in routine Laboratory of Parasitology, Department of Veterinary Preventive Medicine, State University of Londrina in the period January 2000 to December 2011 and the Clinical Laboratory Veterinary January 2008 to December 2011. 2668 fecal samples were analyzed, of which 2290 (85.83% and 378 dogs (14.17% of cats. Of the total, 851 (37,16% dogs and 166 (43,91% feline samples were positive for at least one parasite. Isospora spp. was the most frequent in both species with 8.82% and 11.64% of dogs infected cats. Regarding the form of infection, 740 (86.96% and 139 dogs (83.73% cats had single infection, while 111 (13.04% dogs and 27 (16.27% cats had multiple infection gastrointestinal parasites. The ocurrence of a significant number of parasites and the close contact between animals and humans demonstrates the need for a more effective control and specific, whereas the reduction of the parasitic load of animals and thus decreases environmental exposure of humans to important zoonosis.

Provincializing and Localizing Core-Periphery Relations

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Cilja Harders

2015-11-01

Full Text Available The paper engages engages with core-periphery conceptions because they are a useful "Denkfigur" in a time of increasing global interconnectedness. I argue that the core-periphery metaphor is a useful one because it provides us (1 with a relational tool of analysis and (2 with a focus on asymmetric power-relations. But it also has some serious limitations such as a tendency to be over-deterministic and to be too global in scale. In order to meet these limitations, I suggest to re-scale Prebisch, Amin and Wallersteins global conception of core and periphery to the local scale. I hold that we need to “provincialise” the core-periphery metaphor to borrow Chakrabarty’s (2000 famous term and to make the agency of local actors more relevant to our understanding of political dynamics in the Maghreb, Mashreq and Gulf region. I sketch how “provincialized” and “localized” ways of using the core-periphery metaphor could look like. This part builds on the main ideas Malika Bouziane, Anja Hoffmann and I developed in the introduction to our volume on “Local Politics and Contemporary Transformations in the Arab World” as well as my approach of a “state analysis from below”.

Online measurement of biogenic organic acids in the boreal forest using atmospheric pressure chemical ionization mass spectrometry (APCI-MS)

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Vogel, A. L.; Brüggemann, M.; ńijälä, M.; Ehn, M.; Junninen, H.; Corrigan, A. L.; Petäjä, T.; Worsnop, D. R.; Russell, L. M.; Kulmala, M.; Williams, J.; Hoffmann, T.

2012-04-01

Emission of biogenic volatile organic compounds (BVOCs) by vegetation in the boreal forest and their subsequent atmospheric oxidation leads to the formation of secondary organic aerosol (SOA) which has important impacts on climate and human health. Oxidation of BVOCs produces a variety of mostly unidentified species in oxygenated organic aerosol (OOA). Presently aerosol mass spectrometers (AMS) are able to determine quantitative information about the relative oxygen to carbon content of organic aerosols and thereby reveal the photochemical age and volatility of organic aerosol by distinguishing between low volatile oxygenated organic aerosol (LV-OOA), semivolatile oxygenated organic aerosol (SV-OOA) and hydrocarbon like organic aerosol (HOA)[1]. However, the AMS can usually not be used to measure and quantify single organic compounds such as individual biogenic organic marker compounds. Here we show the results of online measurements of gas and particle phase biogenic acids during HUMPPA-COPEC 2010 at Hyytiälä, Finland. This was achieved by coupling a self built miniature Versatile Aerosol Concentration Enrichment System (mVACES) as described by Geller et al. [2] with an Atmospheric Pressure Chemical Ionization Ion Trap Mass Spectrometer (APCI IT MS; Hoffmann et al., [3]). The benefits of the on-line APCI-MS are soft ionization with little fragmentation compared to AMS, high measurement frequency and less sampling artifacts than in the common procedure of taking filter samples, extraction and detection with LC-MS. Furthermore, the ion trap of the instrument allows MS/MS experiments to be performed by isolation of single m/z ratios of selected molecular species. By subsequent addition of energy, the trapped ions form characteristic fragments which enable structural insight on the molecular level. Comparison of APCI-MS data to AMS data, acquired with a C-ToF-AMS [4], revealed a good correlation coefficient for total organics and sulphate. Furthermore, data show

Echosonography and surgical therapy of facial skin tumors

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Pešić Zoran U.

2002-01-01

Full Text Available In the second half of the 20 century, echosonography has been used in many medical specialties. In 1992 and 1993 highfrequencies echosonography was used in the examination of irritant and allergic skin lesions in order to examine the effects of different therapeuthical agents on the skin lesions [1-4]. Hoffmann used highfrequencies echosonography in the examination of healing of skin lesions [3]. By their incidence skin tumors are the largest group of newly discovered tumors, and their usual location is on the face [5-7]. By clinical examination it is not possible to precisely determine the depth of tumor border; therefore, the radically performed surgical excision is the only correct surgical treatment. The aim of this study was to estimate the results of preoperatively performed high frequencies echosonography in order to reduce the number of incorrectly performed surgical excisions of skin tumors. The group was composed of 40 patients with 45 tumors, who first underwent echosonographic diagnostic procedure (20 MHz, Hadsund electronic, Hadsund Technology, Denmark and then surgical excision; patients in control group (45 patients with 45 tumors were only subjected to surgical excision. Excised tumors were then pathohistologically analyzed, and measurements of tumor depth progression were performed. Margins of pathohistological specimen were controlled for the presence of tumor cells. Results of measurements of tumor depth obtained by echosonography and pathohistological measurements were compared. By Jate's modification of c2 test results regarding correct and incorrect surgical excision in patients and control group were compared. By linear regression analysis results of tumor depth obtained by echosonographic and pathohistologic examinations were compared. Hypoechogen zone echosonographic results were used like criteria for tumor expansion. Results of tumor depth measurements are presented in Table 1. Linear regression analysis showed (R = 0

D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies

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Gaieb, Zied; Liu, Shuai; Gathiaka, Symon; Chiu, Michael; Yang, Huanwang; Shao, Chenghua; Feher, Victoria A.; Walters, W. Patrick; Kuhn, Bernd; Rudolph, Markus G.; Burley, Stephen K.; Gilson, Michael K.; Amaro, Rommie E.

2018-01-01

The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from September 2016 through February 2017. This challenge was based on a dataset of structures and affinities for the nuclear receptor farnesoid X receptor (FXR), contributed by F. Hoffmann-La Roche. The dataset contained 102 IC50 values, spanning six orders of magnitude, and 36 high-resolution co-crystal structures with representatives of four major ligand classes. Strong global participation was evident, with 49 participants submitting 262 prediction submission packages in total. Procedurally, GC2 mimicked Grand Challenge 2015 (GC2015), with a Stage 1 subchallenge testing ligand pose prediction methods and ranking and scoring methods, and a Stage 2 subchallenge testing only ligand ranking and scoring methods after the release of all blinded co-crystal structures. Two smaller curated sets of 18 and 15 ligands were developed to test alchemical free energy methods. This overview summarizes all aspects of GC2, including the dataset details, challenge procedures, and participant results. We also consider implications for progress in the field, while highlighting methodological areas that merit continued development. Similar to GC2015, the outcome of GC2 underscores the pressing need for methods development in pose prediction, particularly for ligand scaffolds not currently represented in the Protein Data Bank (http://www.pdb.org), and in affinity ranking and scoring of bound ligands.

Motion of flux transfer events: a test of the Cooling model

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R. C. Fear

2007-07-01

Full Text Available The simple model of reconnected field line motion developed by Cooling et al. (2001 has been used in several recent case studies to explain the motion of flux transfer events across the magnetopause. We examine 213 FTEs observed by all four Cluster spacecraft under a variety of IMF conditions between November 2002 and June 2003, when the spacecraft tetrahedron separation was ~5000 km. Observed velocities were calculated from multi-spacecraft timing analysis, and compared with the velocities predicted by the Cooling model in order to check the validity of the model. After excluding three categories of FTEs (events with poorly defined velocities, a significant velocity component out of the magnetopause surface, or a scale size of less than 5000 km, we were left with a sample of 118 events. 78% of these events were consistent in both direction of motion and speed with one of the two model de Hoffmann-Teller (dHT velocities calculated from the Cooling model (to within 30° and a factor of two in the speed. We also examined the plasma signatures of several magnetosheath FTEs; the electron signatures confirm the hemisphere of connection indicated by the model in most cases. This indicates that although the model is a simple one, it is a useful tool for identifying the source regions of FTEs.

Helminths of wild hybrid marmosets (Callithrix sp. living in an environment with high human activity

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Alexandre de Oliveira Tavela

Full Text Available The objective of this study was to identify the helminth fauna in hybrid, non-native marmosets, through analysis of fecal samples. The study involved 51 marmosets (genus Callithrix from five groups living in places with levels of human impact in Viçosa-MG. The marmosets were caught using a multiple-entrance trap and were anaesthetized. Feces were collected, refrigerated and analyzed by means of the sedimentation technique (Hoffmann-Pons-Janner. Eggs and parasites were identified, but not counted. Most of the marmosets (86% were parasitized by at least one genus of helminths. Among the infected marmosets, 37% presented co-infection. The intestinal helminths comprised four different taxa: Primasubulura jacchi, Ancylostomatidae, Prosthenorchis sp. and Dilepididae.P. jacchi and Ancylostomatidae had higher prevalences (> 80% and > 40%, respectively and were found in all marmoset groups. Dilepididae species were found in almost all the groups, but only accounted for around 30% of the marmosets. Prosthenorchis sp. showed a relatively low prevalence (< 10% and was only found in one group. Although two parasites are commonly found in marmosets and other primates (P. jacchi and Prosthenorchis sp., our study is the first record for Ancylostomatidae and Dilepididae. Factors like marmosets' feeding behavior and their contact with humans and other species of nonhuman primates seem to be determinants of infection among marmosets.

Synthesis and Use of Stable Isotope Enriched Retinals in the Field of Vitamin A

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Johan Lugtenburg

2010-03-01

Full Text Available The role of vitamin A and its metabolites in the life processes starting with the historical background and its up to date information is discussed in the introduction. Also the role of 11Z-retinal in vision and retinoic acid in the biological processes is elucidated. The essential role of isotopically enriched systems in the progress of vision research, nutrition research etc. is discussed. In part B industrial commercial syntheses of vitamin A by the two leading companies Hoffmann-La Roche (now DSM and BASF are discussed. The knowledge obtained via these pioneering syntheses has been essential for the further synthetic efforts in vitamin A field by other scientific groups. The rest of the paper is devoted to the synthetic efforts of the Leiden group that gives an access to the preparation of site directed high level isotope enrichment in retinals. First the synthesis of the retinals with deuterium incorporation in the conjugated side chain is reviewed. Then, 13C-labeled retinals are discussed. This is followed by the discussion of a convergent synthetic scheme that allows a rational access to prepare any isotopomer of retinals. The schemes that provide access to prepare any possible isotope enriched chemically modified systems are discussed. Finally, nor-retinals and bridged retinals that give access to a whole (as yet incomplete library of possible isotopomers are reviewed.

Short-term plasticity in a monosynaptic reflex pathway to forearm muscles after continuous robot-assisted passive stepping

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Tsuyoshi Nakajima

2016-07-01

Full Text Available Both active and passive rhythmic limb movements reduce the amplitude of spinal cord Hoffmann (H- reflexes in muscles of moving and distant limbs. This could have clinical utility in remote modulation of the pathologically hyperactive reflexes found in spasticity after stroke or spinal cord injury. However, such clinical translation is currently hampered by a lack of critical information regarding the minimum or effective duration of passive movement needed for modulating spinal cord excitability. We therefore investigated the H-reflex modulation in the flexor carpi radialis (FCR muscle during and after various durations (5, 10, 15, and 30 min of passive stepping in 11 neurologically normal subjects. Passive stepping was performed by a robotic gait trainer system (Lokomat® while a single pulse of electrical stimulation to the median nerve elicited H-reflexes in the FCR. The amplitude of the FCR H-reflex was significantly suppressed during passive stepping. Although 30 minutes of passive stepping was sufficient to elicit a persistent H-reflex suppression that lasted up to 15 minutes, 5 minutes of passive stepping was not. The duration of H-reflex suppression correlated with that of the stepping. These findings suggest that the accumulation of stepping-related afferent feedback from the leg plays a role in generating short-term interlimb plasticity in the circuitry of the FCR H-reflex.

Scores for standardization of on-tissue digestion of formalin-fixed paraffin-embedded tissue in MALDI-MS imaging.

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Erich, Katrin; Sammour, Denis A; Marx, Alexander; Hopf, Carsten

2017-07-01

On-slide digestion of formalin-fixed and paraffin-embedded human biopsy tissue followed by mass spectrometry imaging of resulting peptides may have the potential to become an additional analytical modality in future ePathology. Multiple workflows have been described for dewaxing, antigen retrieval, digestion and imaging in the past decade. However, little is known about suitable statistical scores for method comparison and systematic workflow standardization required for development of processes that would be robust enough to be compatible with clinical routine. To define scores for homogeneity of tissue processing and imaging as well as inter-day repeatability for five different processing methods, we used human liver and gastrointestinal stromal tumor tissue, both judged by an expert pathologist to be >98% histologically homogeneous. For mean spectra-based as well as pixel-wise data analysis, we propose the coefficient of determination R 2 , the natural fold-change (natFC) value and the digest efficiency DE% as readily accessible scores. Moreover, we introduce two scores derived from principal component analysis, the variance of the mean absolute deviation, MAD, and the interclass overlap, J overlap , as computational scores that may help to avoid user bias during future workflow development. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2016 Elsevier B.V. All rights reserved.

A new classification method for MALDI imaging mass spectrometry data acquired on formalin-fixed paraffin-embedded tissue samples.

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Boskamp, Tobias; Lachmund, Delf; Oetjen, Janina; Cordero Hernandez, Yovany; Trede, Dennis; Maass, Peter; Casadonte, Rita; Kriegsmann, Jörg; Warth, Arne; Dienemann, Hendrik; Weichert, Wilko; Kriegsmann, Mark

2017-07-01

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) shows a high potential for applications in histopathological diagnosis, and in particular for supporting tumor typing and subtyping. The development of such applications requires the extraction of spectral fingerprints that are relevant for the given tissue and the identification of biomarkers associated with these spectral patterns. We propose a novel data analysis method based on the extraction of characteristic spectral patterns (CSPs) that allow automated generation of classification models for spectral data. Formalin-fixed paraffin embedded (FFPE) tissue samples from N=445 patients assembled on 12 tissue microarrays were analyzed. The method was applied to discriminate primary lung and pancreatic cancer, as well as adenocarcinoma and squamous cell carcinoma of the lung. A classification accuracy of 100% and 82.8%, resp., could be achieved on core level, assessed by cross-validation. The method outperformed the more conventional classification method based on the extraction of individual m/z values in the first application, while achieving a comparable accuracy in the second. LC-MS/MS peptide identification demonstrated that the spectral features present in selected CSPs correspond to peptides relevant for the respective classification. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2016 Elsevier B.V. All rights reserved.

[Performance of self-help groups and their economic evaluation].

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Engelhardt, H D; Trojan, A; Nickel, S

2009-01-01

Hoffmann von Fallersleben is quoted with the sentence "Self-help is worthwhile, because it does not demand anything from others". This sounds catchy; it is, however, wrong: Self-help groups ask for support, particularly for financial resources for the work of either individual, highly organized self-help associations or for general support of self-help groups via local contact and information centers ("contact points for self-help groups"). With this request for economic "investments" in self-help, the question arises whether this is profitable for the country, the local authority or the social health insurance. In principle, the initial answer to this is: yes, the work of self-help groups is worthwhile for a single person, but also for the larger community, as various kinds of services are provided by self-help groups and organizations. Despite many surveys of members or co-operation partners which show positive effects of self-help groups, the question remains whether services of self-help groups can be measured and economically evaluated. The socio- political question regarding funding is closely connected to the idea of an economic evaluation of self-help groups. The aim of this article is to summarize and discuss which empiric approaches and findings are available on this subject. The monetary value for the work done per member of self-help groups and year lies between approximately 700 and 900 EUR.

Age and speleogenesis of epigenic gypsum caves in the northern Apennines (Italy)

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Columbu, Andrea; Chiarini, Veronica; De Waele, Jo; Drysdale, Russell; Forti, Paolo; Hellstrom, John; Woodhead, Jon

2016-04-01

Triassic and Messinian gypsum beds host the majority of the caves in the eastern flank of the northern Apennines. To date, more than six hundreds voids have been mapped, including the longest known epigenic gypsum cave system in the world (Spipola-Acquafredda, ~11 km of tunnels) (De Waele et al., 2013). Superimposed caves are typically sub-horizontal (Klimchouk, 2000) and connected through vertical shafts, reflecting the palaeo base-level variations. When preserved, river terraces at the surface lie at the same palaeo altitude of the base level and horizontal cave passages. Notwithstanding the well-known geology of the area known (Vai and Martini, 2001), the age of these caves has been greatly underestimated in the past. Considering the rapid dissolution of the gypsum and uplifting of the area, the start of speleogenesis activity was considered to have occurred during the last glacial age. The age of karst voids can be only indirectly estimated by the dating of the infilling sediments. U-Th dating on carbonate speleothems provides high-precision and accurate ages (Hellstrom, 2003; Scholz and Hoffmann, 2008). We thus applied this methodology to 20 speleothems coming from 14 different caves belonging to the Monte Tondo, Spipola Acquafredda, Castelnuovo, Stella-Rio Basino and Brisighella systems. The results show that: i) caves were forming since at least ~300 ka; ii) the peak of speleogenesis was reached during relatively cold climate stages, when rivers formed terraces at the surface and aggradation caused paragenesis in the stable cave levels (Columbu et al., 2015). Besides the significant contribution to the understanding of the Apennines evaporite karst evolution, this study (and its further advancement) may also refine knowledge of the local vs regional uplifting rates and base-level variations since the late Pleistocene (Wegmann and Pazzaglia, 2009). References Columbu, A., De Waele, J., Forti, P., Montagna, P., Picotti, V., Pons-Branchu, E., Hellstrom, J

Comportamento ingestivo e ingestão de água em caprinos e ovinos alimentados com feno e silagem de Maniçoba Ingestive behavior and water intake in goats and sheep fed with Maniçoba hay and silage

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Edson Ricardo de Farias Zumba

2010-12-01

Full Text Available Objetivou-se avaliar o comportamento ingestivo e consumo de água de caprinos e ovinos alimentados com feno ou silagem de maniçoba (Manihot epruinosa Pax & Hoffmann. Foram empregados sete caprinos sem padrão racial definido, com peso médio inicial de 14,6kg e oito ovinos da raça Santa Inês de 13,9kg. Os animais foram mantidos em baias individuais e distribuídos em delineamento experimental inteiramente casualizado, em esquema fatorial 2 x 2 (forma de conservação x espécie animal. Foram avaliados os consumos de matéria seca, matéria orgânica, proteína bruta, fibra em detergente neutro, extrato etéreo, carboidratos totais e carboidratos não fibrosos. Para estudo de comportamento ingestivo, os animais foram observados a cada cinco minutos durante 24h. Os animais alimentados com feno de maniçoba mostraram maior consumo de proteína bruta e extrato etéreo (56 e 24 g/dia em relação àqueles que receberam a maniçoba conservada pela fermentação (42 e 14g/dia, respectivamente. Não houve diferença entre os tempos de alimentação (405,00 e 399,38 min, ruminação (625,63 e 599,38 min e ócio (413,13 e 44,01 min entre os animais alimentados com silagem e feno de maniçoba, respectivamente. No entanto, os animais alimentados com maniçoba conservada mediante fermentação apresentaram menor consumo de água no bebedouro (0,473vs 0,990kg/dia para silagem e feno, respectivamente. Assim, conclui-se que o método de conservação de maniçoba não interferiu no comportamento ingestivo, mas a ingestão da maniçoba conservada mediante fermentação leva ao menorThe objective of this study was to evaluate the ingestive behavior and water intake of goats and sheep fed Manihot epruinosa Pax & Hoffmann silage or hay. Seven goats (average live weight 14,6 ± 1,24kg and eight sheep (average live weight 13,8 ± 1,22kg were allotted to individual pens. They were distributed in a completely randomized design, 2 x 2 factorial outline composed of

Spectroscopic investigations of the B12-binding subunit of glutamate mutase: refined solution structure of the complex with the B12-nucleotide, dynamics and binding studies with two corrinoid cofactors

International Nuclear Information System (INIS)

Eichmueller, C.

2002-06-01

Glutamate mutase is an enzyme isolated from Clostridium tetanomorphum and Clostridium cochlearum. It catalyses the reversible rearrangement of (2S)-glutamate to (2S,3S)-3-methylaspartate. Coenzyme B12 is required as cofactor for an active enzyme, as the first step of the catalytic cycle is the homolytic cleavage of the cobalt-carbon bond. The rearrangement itself follows a radical mechanism. The holoenzyme is an alpha2beta2 heterotetramer containing two identical catalytic and two B12 binding domains, as well as two coenzyme B12 molecules. The smaller B12 binding domain from Clostridium tetanomorphum, MutS, is known to bind coenzyme B12 in its unusual 'base-off' form. A conserved histidine residue coordinates to the cobalt atom instead of the normally coordinated dimethlybenzimidole in free coenzyme B12. In the present work a refined solution structure of the B12 binding subunit from Clostridium tetanomorphum (MutS) in complex with the detached nucleotide loop of coenzyme B12 has been determined using nuclear magnetic resonance. The found topology is almost identical to the crystal structure of glutamate mutase from C.cochlearum [Reitzer et al., 1999], in contrast to the solution structures obtained for apo-MutS [Hoffmann et al., 2001; Tollinger et al., 1998] and apo-GlmS [Hoffmann et al., 1999]. In these two structures a helix at one side of the B12 nucleotide loop binding pocket is mostly unstructured and shows motions on a microsecond to millisecond timescale. The previously found stabilization of this helix upon B12-nucleotide binding [Tollinger et al., 2001] was confirmed using 13C and 15N labeled MutS. Some differences are found in the structure of the binding pocket and the bound nucleotide loop compared to the crystal structure. This indicates that additional conformational changes occur upon binding of the corrin ring of coenzyme B12. NMR-relaxation measurements performed on apo-MutS showed interesting slow molecular motions not only in the mainly

CONTAMINAÇÃO DE HORTALIÇAS POR ENTEROPARASITAS E SALMONELLA SPP. EM PRESIDENTE PRUDENTE, SÃO PAULO, BRASIL

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Vamilton Alvares Santarém

2012-06-01

Full Text Available The aim of this study was to evaluate the frequency of contamination of vegetables by infective forms of helminths and protozoa commercialized in the municipality of Presidente Prudente, São Paulo, Brazil. Samples of two varieties of lettuce and one of watercress, parsley, chives, and packets of parsley and chives were collected from 96 out of 121 commercial establishments registered in the municipality. Samples were washed with Extran MA 02 0.5% and the resulting fluid subjected to techniques of Baermann, Hoffmann and Faust, in order to recovery parasite. Bacterial culture for Salmonella spp. was performed following the steps of pre-enrichment, selective enrichment, plating and differential biochemical classification. It was observed that 33.06% of the samples were contaminated by parasitic structures. The highest contaminations were present in watercress (69.2% and parsley (47.6%, while the lowest occurred in chives (20.7% and lettuce (20.0%. The eggs of trichostrongylidae type were most often found in the samples. Giardia duodenalis cysts were recovered in 9.1% of the samples. Regarding the presence of Salmonella spp., only one strain was isolated in a sample of watercress (1.04%. It was conclude that there is a need for a health education campaign for farmers and vegetables merchants as well as for consumers, based on hygienic techniques, in order to reduce the risks of infection by infectious and parasitic agents during the ingestion of these foods.

Lo ominoso y la mirada, lo real en el hombre de arena. // The ominous and the look, the real in the "Sandman".

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Felipe Galeano Arias.

2009-06-01

Full Text Available To Freud, the references to literature were useful to illustrate some points and aspects of the theory he built from the clinic, proving it is literature which has something to teach psychoanalysis and not the other way round. Like this, and with Lacan’s teachings, we can restate it is the poet’s "well-saying" what, in his lyric poetry, in his saying, says, illustrates and explains that what psychoanalyst's words sometimes are not enough for. E.T.A. Hoffmann’s “The Sandman” is only an example, and the next writing, an attempt to understand from the reading of this story particularly. // A Freud las referencias a la literatura le sirvieron para ilustrar ciertos puntos y aspectos de la teoría que construyó a partir de la clínica, demostrando que es la literatura la que tiene algo que enseñar el psicoanálisis y no al revés. Así, y con la enseñanza de Lacan, podemos reafirmar que es el “bien-decir” del poeta el que en su lírica, en su decir, dice, ilustra y explica aquello para lo cual las palabras del psicoanalista a veces resultan cortas. El “Hombre de arena”, de E.T.A. Hoffmann es apenas un ejemplo, y el siguiente escrito un intento de desciframiento a partir de la lectura de este particular cuento.

Quantification of low molecular weight compounds by MALDI imaging mass spectrometry - A tutorial review.

Science.gov (United States)

Rzagalinski, Ignacy; Volmer, Dietrich A

2017-07-01

Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) permits label-free in situ analysis of chemical compounds directly from the surface of two-dimensional biological tissue slices. It links qualitative molecular information of compounds to their spatial coordinates and distribution within the investigated tissue. MALDI-MSI can also provide the quantitative amounts of target compounds in the tissue, if proper calibration techniques are performed. Obviously, as the target molecules are embedded within the biological tissue environment and analysis must be performed at their precise locations, there is no possibility for extensive sample clean-up routines or chromatographic separations as usually performed with homogenized biological materials; ion suppression phenomena therefore become a critical side effect of MALDI-MSI. Absolute quantification by MALDI-MSI should provide an accurate value of the concentration/amount of the compound of interest in relatively small, well-defined region of interest of the examined tissue, ideally in a single pixel. This goal is extremely challenging and will not only depend on the technical possibilities and limitations of the MSI instrument hardware, but equally on the chosen calibration/standardization strategy. These strategies are the main focus of this article and are discussed and contrasted in detail in this tutorial review. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2016 Elsevier B.V. All rights reserved.

Genomic epidemiology of global VIM-producing Enterobacteriaceae.

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Matsumura, Yasufumi; Peirano, Gisele; Devinney, Rebekah; Bradford, Patricia A; Motyl, Mary R; Adams, Mark D; Chen, Liang; Kreiswirth, Barry; Pitout, Johann D D

2017-08-01

International data on the molecular epidemiology of Enterobacteriaceae with VIM carbapenemases are limited. We performed short read (Illumina) WGS on a global collection of 89 VIM-producing clinical Enterobacteriaceae (2008-14). VIM-producing (11 varieties within 21 different integrons) isolates were mostly obtained from Europe. Certain integrons with bla VIM were specific to a country in different species and clonal complexes (CCs) (In 87 , In 624 , In 916 and In 1323 ), while others had spread globally among various Enterobacteriaceae species (In 110 and In 1209 ). Klebsiella pneumoniae was the most common species ( n  = 45); CC147 from Greece was the most prevalent clone and contained In 590 -like integrons with four different bla VIM s. Enterobacter cloacae complex was the second most common species and mainly consisted of Enterobacter hormaechei ( Enterobacter xiangfangensis , subsp. steigerwaltii and Hoffmann cluster III). CC200 (from Croatia and Turkey), CC114 (Croatia, Greece, Italy and the USA) and CC78 (from Greece, Italy and Spain) containing bla VIM-1 were the most common clones among the E. cloacae complex. This study highlights the importance of surveillance programmes using the latest molecular techniques in providing insight into the characteristics and global distribution of Enterobacteriaceae with bla VIM s. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Simulation of warpage induced by non-isothermal crystallization of co-polypropylene during the SLS process

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Amado, Antonio; Schmid, Manfred; Wegener, Konrad

2015-05-01

Polymer processing using Additive Manufacturing Technologies (AM) has experienced a remarkable growth during the last years. The application range has been expanding rapidly, particularly driven by the so-called consumer 3D printing sector. However, for applications demanding higher requirements in terms of thermo-mechanical properties and dimensional accuracy the long established AM technologies such as Selective Laser Sintering (SLS) do not depict a comparable development. The higher process complexity hinders the number of materials that can be currently processed and the interactions between the different physics involved have not been fully investigated. In case of thermoplastic materials the crystallization kinetics coupled to the shrinkage strain development strongly influences the stability of the process. Thus, the current investigation presents a transient Finite Element simulation of the warpage effect during the SLS process of a new developed polyolefin (co-polypropylene) coupling the thermal, mechanical and phase change equations that control the process. A thermal characterization of the material was performed by means of DSC, integrating the Nakamura model with the classical Hoffmann-Lauritzen theory. The viscoelastic behavior was measured using a plate-plate rheometer at different degrees of undercooling and a phase change-temperature superposition principle was implemented. Additionally, for validation porpoises the warpage development of the first sintered layers was captured employing an optical device. The simulation results depict a good agreement with experimental measurements of deformation, describing the high sensitivity of the geometrical accuracy of the sintered parts related to the processing conditions.

The work of the couple Brailowsky in the mirror of Serbian critiques

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Mosusova Nadežda

2003-01-01

Full Text Available Leonid (1867-1937 and Rimma (1877-1959 Brailowsky brought to Belgrade National theatre (together with other Russian emigrated stage and costume designers the spirit of the World of Art (Mir Iskusstva, making décor and costumes for 18 performances during the period of 1921-1924. Les romanesques by Edmond Rostand, Le malade imaginaire by Molière, Shakespeare's Richard III, Merchant of Venice and King Lear and two Serbian dramas, Offenbach's Hoffmann's Tales, Faust by Gounod, Smetana's Bartered Bride, Bizet's Carmen Onegin and Queen of Spades by Tchaikovsky, Massenet's Manon, The Tsar's Bride by Rimsky-Korsakov, The Wedding of Miloš by Petar Konjović, the Serbian opera composer, two ballets, Sheherazade and Nutcracker. The artists, husband and wife, were praised for their modernization of the Belgrade scene, for their vivid realization of sets and costumes, for their novelties, especially in Serbian historical dramas by Branislav Nušić and Milutin Bojić, and Shakespeare as well. In operas and ballets they were also respected in some extent, but the pictorial, sometimes independent value of their scenic work, although inspired by music, arouse opposing questions among the musical critics, who could not accept their too bright colors which once conquered Paris in the scenic interpretation of Leon Bakst or Nikolai Roerich. To avoid resistance of Belgrade critics the couple decided to leave Yugoslav capital for Italy where they continued successfully their artistic career.

To attach or not to attach? The effect of carrier surface morphology and topography on attachment of phoretic deutonymphs of Uropoda orbicularis (Acari)

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Bajerlein, Daria; Adamski, Zbigniew; Kacalak, Wojciech; Tandecka, Katarzyna; Wiesner, Maciej; Jurga, Stefan

2016-08-01

Previous studies on preferences of phoretic deutonymphs of Uropodina for attachment sites have shown that they frequently select smooth and hydrophobic surfaces. The aim of our study was to provide the detailed morphological and topographical characteristics of beetle body surfaces to which deutonymphs frequently attach and to verify how the presence of setae and surface sculpture affects deutonymph attachment. The study was conducted on Uropoda orbicularis (Müller, 1776) and its common beetle carriers: Aphodius prodromus (Brahm, 1790), Aphodius fimetarius (Linnaeus, 1758), Onthophagus nuchicornis (Linnaeus, 1758) and Margarinotus carbonarius (Hoffmann, 1803). Morphology and topography of elytra, femora, propygidia and pygidia of beetles were analysed mainly using SEM methods supported with CLSM and AFM techniques. The hypothesis that deutonymphs may attach to surfaces covered with setae, if seta density is low enough not to disturb mite movement, was tested. The study revealed that deutonymphs attach to surfaces of various types as follows: (i) smooth, (ii) hairy, i.e., covered with setae, (iii) flat and (iv) sculptured. Smooth body parts and body parts covered with setae of low density were most frequently and intensively occupied with deutonymphs. Surfaces of high seta density were avoided by mites. Within elytra of Aphodius beetles, deutonymphs definitely preferred flat surfaces of elytral intervals. On the contrary, densely punctuated propygidium and pygidium in M. carbonarius were heavily infested with deutonymphs. We conclude that carrier surface morphology and topography are important for Uropodina deutonymph attachment, but these two factors cannot fully explain the observed relation.

Quadriceps muscle function after rehabilitation with cryotherapy in patients with anterior cruciate ligament reconstruction.

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Hart, Joseph M; Kuenze, Christopher M; Diduch, David R; Ingersoll, Christopher D

2014-01-01

Persistent muscle weakness after anterior cruciate ligament (ACL) reconstruction may be due to underlying activation failure and arthrogenic muscle inhibition (AMI). Knee-joint cryotherapy has been shown to improve quadriceps function transiently in those with AMI, thereby providing an opportunity to improve quadriceps muscle activation and strength in patients with a reconstructed ACL. To compare quadriceps muscle function in patients with a reconstructed ACL who completed a 2-week intervention including daily cryotherapy (ice bag), daily exercises, or both. Cross-sectional study. Laboratory. A total of 30 patients with reconstructed ACLs who were at least 6 months post-index surgery and had measurable quadriceps AMI. The patients attended 4 supervised visits over a 2-week period. They were randomly assigned to receive 20 minutes of knee-joint cryotherapy, 1 hour of therapeutic rehabilitation exercises, or cryotherapy followed by exercises. We measured quadriceps Hoffmann reflex, normalized maximal voluntary isometric contraction torque, central activation ratio using the superimposed-burst technique, and patient-reported outcomes before and after the intervention period. After the 2-week intervention period, patients who performed rehabilitation exercises immediately after cryotherapy had higher normalized maximal voluntary isometric contraction torques (P = .002, Cohen d effect size = 1.4) compared with those who received cryotherapy alone (P = .16, d = 0.58) or performed exercise alone (P = .16, d = 0.30). After ACL reconstruction, patients with AMI who performed rehabilitation exercises immediately after cryotherapy experienced greater strength gains than those who performed cryotherapy or exercises alone.

Visualization of acoustic particle interaction and agglomeration: Theory evaluation

International Nuclear Information System (INIS)

Hoffmann, T.L.; Koopmann, G.H.

1997-01-01

In this paper experimentally observed trajectories of particles undergoing acoustically induced interaction and agglomeration processes are compared to and validated with numerically generated trajectories based on existing agglomeration theories. Models for orthokinetic, scattering, mutual radiation pressure, and hydrodynamic particle interaction are considered in the analysis. The characteristic features of the classical orthokinetic agglomeration hypothesis, such as collision processes and agglomerations due to the relative entrainment motion, are not observed in the digital images. The measured entrainment rates of the particles are found to be consistently lower than the theoretically predicted values. Some of the experiments reveal certain characteristics which may possibly be related to mutual scattering interaction. The study's most significant discovery is the so-called tuning fork agglomeration [T. L. Hoffmann and G. H. Koopmann, J. Acoust. Soc. Am. 99, 2130 endash 2141 (1996)]. It is shown that this phenomenon contradicts the theories for mutual scattering interaction and mutual radiation pressure interaction, but agrees with the acoustic wake effect model in its intrinsic feature of attraction between particles aligned along the acoustic axis. A model by Dianov et al. [Sov. Phys. Acoust. 13 (3), 314 endash 319 (1968)] is used to describe this effect based on asymmetric flow fields around particles under Oseen flow conditions. It is concluded that this model is consistent with the general characteristics of the tuning fork agglomerations, but lacks certain refinements with respect to accurate quantification of the effect. copyright 1997 Acoustical Society of America

An in vitro radiographic analysis of the density of dental luting cements as measured by CCD-based digital radiography.

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Antonijevic, Djordje; Jevremovic, Danimir; Jovanovic, Svetlana; Obradovic-Djuricic, Kosovka

2012-05-01

According to the ISO, the radiopacity of luting cements should be equal to or greater than that of aluminum. The aim of this in vitro study was to determine the radiopacity of 13 commercially available dental luting cements and compare them with human enamel and dentin. Five classes of luting cements were evaluated: zinc phosphate (Cegal N and Harvard Zinc Phosphate), zinc polycarboxylate (Harvard Polycarboxylate and Hoffmann's Carboxylate), glass ionomers (Ketac Cem Easymix, Ketac Cem Radiopaque, and Fuji I), resin-modified glass ionomer (Rely X Luting), and resin cements (Multilink Automix, Variolink II, Speed CEM, Rely X Unicem Automix, and three shades of Variolink Veneer). Tooth slices served as controls. Five specimens of each material measuring 8 mm in diameter and 1 mm thick were prepared and radiographed alongside tooth slices and an aluminum stepwedge using a Trophy RVG sensor. The radiopacity values were expressed in mm Al and analyzed by the ANOVA and Tukey tests (P cements examined except Variolink Veneer had significantly higher radiopacities than that of dentin. Rely X Unicem Automix, glass ionomer, and resin-modified glass-ionomer cements demonstrated radiopacities that were not significantly different with respect to enamel. Zinc phosphate, zinc polycarboxylate, and three of the resin cements presented radiopacity values that were significantly greater than that of enamel. Almost all the investigated materials presented an acceptable radiopacity. Radiopacity of dental cements seems to depend more on the presence of elements with high atomic numbers than on the type of the material.

Short term response of a peatland to warming and drought - climate manipulation experiment in W Poland

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Juszczak, Radosław; Chojnicki, Bogdan; Urbaniak, Marek; Leśny, Jacek; Silvennoinen, Hanna; Lamentowicz, Mariusz; Basińska, Anna; Gąbka, Maciej; Stróżecki, Marcin; Samson, Mateusz; Łuców, Dominika; Józefczyk, Damian; Hoffmann, Mathias; Olejnik, Janusz

2016-04-01

Central European peatlands are highly vulnerable as potential sources of carbon (C) to the atmosphere under anticipated climate changes, namely warming and drought (Fenner & Freeman 2011). We carried out a field manipulation experiment at Rzecin peatland in Poland to assess how those changes impact carbon balance, vegetation and water chemistry. The field site consists of three times replicated treatments (control, CO; simulated warming, W; prolonged drought, D and warming & drought, W+D). Temperature (T) was increased year around with infrared heaters (400W × 4 per site, approx. 60 Wṡm-2 addition of LW radiation, Kimball 2005) and precipitation was reduced with automatic curtain during growth seasons at night. The manipulation was successful yielding up to 0.4 oC and 1.0 oC T increases in air (30 cm height) and soil (5 cm depth), respectively, as well as a 35 % lower precipitation (in 2015). To study the C exchange we developed an automatic mobile platform for measuring CO2/CH4/H2O fluxes (LGR) as well as for 13CO2 and 13CH4 fluxes (PICARRO CRDS G2201-i) with dynamic ecosystem chambers (for NEE and Reco) and for simultaneous measurements of surface optical properties. Gap filling of the fluxes was done according to Hoffmann et al. 2015. In the very dry 2015, Rzecin peatland was a net source of CO2to the atmosphere (80 gCṡm-2yr-1). Warming and drought considerably diminished the source strength (7 gCṡm-2yr-1at the W+D site), due to lower cumulative respiration (Reco the smallest, 610 gC m-2yr-1, at W+D site). The highest CO2 emissions were measured from the site that was only warmed (W site, Reco 680 gCṡm-2yr-1), emphasizing the importance of drought in inhibiting respiration. Temperature increase also provoked the productivity (highest GPP at W site, -620 gCṡm-2yr-1), while drought yielded the lowest productivity (lowest GPP at D site, -550 gCṡm-2yr-1). Different vegetation parameters further support the C exchange estimates. Generally, warmer

Development and application of compact denuder sampling techniques with in situ derivatization followed by gas chromatography-mass spectrometry for halogen speciation in volcanic plumes

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Rüdiger, Julian; Bobrowski, Nicole; Hoffmann, Thorsten

2015-04-01

Volcanoes are a large source for several reactive atmospheric trace gases including sulphur and halogen containing species. The detailed knowledge of volcanic plume chemistry can give insights into subsurface processes and can be considered as a useful geochemical tool for monitoring of volcanic activity, especially halogen to sulphur ratios (e.g. Bobrowski and Giuffrida, 2012; Donovan et al., 2014). The reactive bromine species bromine monoxide (BrO) is of particular interest, because BrO as well as SO2 are readily measurable by UV spectrometers at a safe distance. Furthermore it is formed in the plume by a multiphase reaction mechanism under depletion of ozone in the plume. The abundance of BrO changes as a function of the reaction time and therefore distance from the vent as well as the spatial position in the plume. Due to the lack of analytical approaches for the accurate speciation of certain halogens (HBr, Br2, Br, BrCl, HOBr etc.) there are still uncertainties about the magnitude of volcanic halogen emissions and in particular their specificationtheir species and therefore also in the understanding of the bromine chemistry in volcanic plumes (Bobrowski et al., 2007). In this study, the first application of a 1,3,5-trimethoxybenzene (1,3,5-TMB)-coated gas diffusion denuder (Huang and Hoffmann, 2008) on volcanic gases proved to be suitable to collect selectively gaseous bromine species with oxidation states of +1 or 0 (Br2 and BrO(H)), while being ignorant to HBr (OS -1). The reaction of 1,3,5-TMB with bromine gives 1-bromo-2,4,6-trimethoxybenzene (1-bromo-2,4,6-TMB) - other halogens give corresponding products. The diffusion denuder technique allows sampling of gaseous compounds exclusively without collecting particulate matter. Choosing a flow rate of 500 mL-min-1 and a denuder length of 0.5 m a nearly quantitative collection efficiency was achieved. Solvent elution of the derivatized analytes and subsequent analysis with gas chromatography

NOTE TASSONOMICHE E NOMENCLATORIALI SU ALCUNE SPECIE PALEARTICHE DI SIBINIA E TYCHIUS (COLEOPTERA, CURCULIONIDAE

Directory of Open Access Journals (Sweden)

Roberto Caldara

2009-10-01

attalica Gyllenhal var. unicolor Desbrochers, 1895: 102 (non Fåhraeus, 1843; Sibinia attalica subsp. tibiella var. desbordesi Hoffmann, 1954; Tychius pusillus var. inermis Hoffmann, 1954. Sibinia suturella Motschulsky, 1858 (non Fårhaeus, 1843 viene trasferita al genere Smicronyx.

Past climate variability between 97 and 7 ka reconstructed from a multi proxy speleothem record from Western Cuba

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Winterhalder, Sophie; Scholz, Denis; Mangini, Augusto; Spötl, Christoph; Jochum, Klaus Peter; Pajón, Jesús M.

2016-04-01

. Due to the competing influence of the NA, the Gulf of Mexico and the Pacific Ocean, the proposed severe changes in the tropical hydrological cycle during that time (such as variations of the ITCZ, insolation and the thermohaline circulation (THC)) have potentially lead to significant changes in sources and trajectories of precipitation in Western Cuba. Our record, thus, provides an important contribution towards understanding and differentiating these parameters on Caribbean climate during glacial climate changes. References: Fensterer, C., Scholz, D., Hoffmann, D., Spötl, C., Pajón, J.M., Mangini, A., 2012. Cuban stalagmite suggests relationship between Caribbean precipitation and the Atlantic Multidecadal Oscillation during the past 1.3 ka. The Holocene, 0959683612449759. Fensterer, C., Scholz, D., Hoffmann, D.L., Spötl, C., Schröder-Ritzrau, A., Horn, C., Pajón, J.M., Mangini, A., 2013. Millennial-scale climate variability during the last 12.5 ka recorded in a Caribbean speleothem. Earth and Planetary Science Letters 361, 143-151. Winter, A., Miller, T., Kushnir, Y., Sinha, A., Timmermann, A., Jury, M.R., Gallup, C., Cheng, H., Edwards, R.L., 2011. Evidence for 800years of North Atlantic multi-decadal variability from a Puerto Rican speleothem. Earth and Planetary Science Letters 308, 23-28.

Effect of display location on control-display stereotype strength for translational and rotational controls with linear displays.

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Chan, Alan H S; Hoffmann, Errol R

2015-01-01

Experiments were designed to investigate the effects of control type and display location, relative to the operator, on the strength of control/display stereotypes. The Worringham and Beringer Visual Field principle and an extension of this principle for rotary controls (Hoffmann E.R., and Chan A.H.S. 2013). "The Worringham and Beringer 'Visual Field' Principle for Rotary Controls. Ergonomics." 56 (10): 1620-1624) indicated that, for a number of different control types (rotary and lever) on different planes, there should be no significant effect of the display location relative to the seated operator. Past data were surveyed and stereotype strengths listed. Experiments filled gaps where data are not available. Six different control types and seven display locations were used, as in the Frame of Reference Transformation Tool (FORT) model of Wickens et al. (Wickens, C.D., Keller, J.W., and Small, R.L. (2010). "Left. No, Right! Development of the Frame of Reference Transformation Tool (FORT)." Proceedings of the Human Factors and Ergonomics Society 54th Annual Meeting September 2010, 54: 1022-1026). Control/display arrangements with high stereotype strengths were evaluated yielding data for designers of complex control/display arrangements where the control and display are in different planes and for where the operator is moving. It was found possible to predict display/control arrangements with high stereotype strength, based on past data. Practitioner Summary: Controls and displays in complex arrangements need to have high compatibility. These experiments provide arrangements for six different controls (rotary and translational) and seven different display locations relative to the operator.

Live cell imaging reveals different modes of cytotoxic action of extracts derived from commonly used luting cements.

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Trumpaitė-Vanagienė, Rita; Čebatariūnienė, Alina; Tunaitis, Virginijus; Pūrienė, Alina; Pivoriūnas, Augustas

2018-02-01

To compare cytotoxicity of extracts derived from commonly used luting cements: Hoffmann's Zinc Phosphate (ZPC), GC Fuji Plus Resin Modified Glass Ionomer (RMGIC) and 3M ESPE RelyX Unicem Resin Cement (RC) on primary human gingival fibroblasts (HGFs). HGFs were exposed to different concentrations of the ZPC, RMGIC and RC extracts. The cytotoxicity was assessed with the PrestoBlue Cell Viability Reagent and viable cells were counted by a haemocytometer using the trypan blue exclusion test. In order to determine the primary mechanism of the cell death induced by extracts from different luting cements, the real-time monitoring of caspase-3/-7 activity and membrane integrity of cells was employed. The extracts from the RMGIC and ZPC decreased the metabolic activity and numbers of viable cells. Unexpectedly, the extracts from the RC evoked only small effects on the metabolic activity of HGFs with a decreasing number of viable cells in a dose-and time-dependent manner. The live cell imaging revealed that the apoptosis was the primary mechanism of a cell death induced by the extracts derived from the RMGIC, whereas the extracts from the RC and ZPC induced a cell death through a necrotic and caspase-independent pathway. The apoptosis was the primary mechanism of the cell death induced by the extracts derived from the RMGIC, whereas the extracts from the RC and ZPC induced a cell death via a necrotic pathway. We suggest that metabolic assays commonly used to assess the cytotoxicity of luting cements should be validated by alternative methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

The effect of Bobath approach on the excitability of the spinal alpha motor neurones in stroke patients with muscle spasticity.

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Ansari, N N; Naghdi, S

2007-01-01

A clinical study was performed to evaluate the efficacy of the Bobath approach on the excitability of the spinal alpha motor neurones in patients with poststroke spasticity. Ten subjects ranging in age from 37 through 76 years (average 60 years) with ankle plantarflexor spasticity secondary to a stroke were recruited and completed the trial. They had physiotherapy according to Bobath concept for ten treatment sessions, three days per week. Two repeated measures, one before and another after treatment, were taken to quantify clinical efficacy. The effect of this type of therapy on the excitability of alpha motor neurones (aMN) was assessed by measuring the latency of the Hoffmann reflex (H-reflex) and the Hmax/Mmax ratio. The original Ashworth scale and ankle range of motion were also measured. The mean HmaxlMmax ratio on the affected side at baseline was high in the study patients. However, there were no statistically significant differences in the HmaxlMmax ratio or in the H-reflex latency between the baseline values and those recorded after therapy intervention. Before treatment, the HmaxlMmax ratio was significantly higher in the affected side than in the unaffected side. However, it was similar at both sides after treatment. Following treatment, the significant reduction in spasticity was clinically detected as measured with the original Ashworth scale. The ankle joint active and passive range of motion was significantly increased. In conclusion, Bobath therapy had a statistically significant effect on the excitability of the aMN in the affected side compared to the unaffected side in stroke patients with muscle spasticity.

Stress Management Apps With Regard to Emotion-Focused Coping and Behavior Change Techniques: A Content Analysis.

Science.gov (United States)

Christmann, Corinna Anna; Hoffmann, Alexandra; Bleser, Gabriele

2017-02-23

Chronic stress has been shown to be associated with disease. This link is not only direct but also indirect through harmful health behavior such as smoking or changing eating habits. The recent mHealth trend offers a new and promising approach to support the adoption and maintenance of appropriate stress management techniques. However, only few studies have dealt with the inclusion of evidence-based content within stress management apps for mobile phones. The aim of this study was to evaluate stress management apps on the basis of a new taxonomy of effective emotion-focused stress management techniques and an established taxonomy of behavior change techniques. Two trained and independent raters evaluated 62 free apps found in Google Play with regard to 26 behavior change and 15 emotion-focused stress management techniques in October 2015. The apps included an average of 4.3 behavior change techniques (SD 4.2) and 2.8 emotion-focused stress management techniques (SD 2.6). The behavior change technique score and stress management technique score were highly correlated (r=.82, P=.01). The broad variation of different stress management strategies found in this sample of apps goes in line with those found in conventional stress management interventions and self-help literature. Moreover, this study provided a first step toward more detailed and standardized taxonomies, which can be used to investigate evidence-based content in stress management interventions and enable greater comparability between different intervention types. ©Corinna Anna Christmann, Alexandra Hoffmann, Gabriele Bleser. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 23.02.2017.

Gamification in Stress Management Apps: A Critical App Review.

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Hoffmann, Alexandra; Christmann, Corinna A; Bleser, Gabriele

2017-06-07

In today's society, stress is more and more often a cause of disease. This makes stress management an important target of behavior change programs. Gamification has been suggested as one way to support health behavior change. However, it remains unclear to which extend available gamification techniques are integrated in stress management apps, and if their occurrence is linked to the use of elements from behavior change theory. The aim of this study was to investigate the use of gamification techniques in stress management apps and the cooccurrence of these techniques with evidence-based stress management methods and behavior change techniques. A total of 62 stress management apps from the Google Play Store were reviewed on their inclusion of 17 gamification techniques, 15 stress management methods, and 26 behavior change techniques. For this purpose, an extended taxonomy of gamification techniques was constructed and applied by 2 trained, independent raters. Interrater-reliability was high, with agreement coefficient (AC)=.97. Results show an average of 0.5 gamification techniques for the tested apps and reveal no correlations between the use of gamification techniques and behavior change techniques (r=.17, P=.20), or stress management methods (r=.14, P=.26). This leads to the conclusion that designers of stress management apps do not use gamification techniques to influence the user's behaviors and reactions. Moreover, app designers do not exploit the potential of combining gamification techniques with behavior change theory. ©Alexandra Hoffmann, Corinna A Christmann, Gabriele Bleser. Originally published in JMIR Serious Games (http://games.jmir.org), 07.06.2017.

Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia.

Science.gov (United States)

Nagao, Shigeto; Yokota, Osamu; Nanba, Reiko; Takata, Hiroshi; Haraguchi, Takashi; Ishizu, Hideki; Ikeda, Chikako; Takeda, Naoya; Oshima, Etsuko; Sakane, Katsuaki; Terada, Seishi; Ihara, Yuetsu; Uchitomi, Yosuke

2012-12-15

We report an autopsy case of progressive supranuclear palsy (PSP) that clinically showed only slowly progressive and symmetric upper motor neuron syndrome over a disease course of 12 years. A female patient initially exhibited dysarthria at the age of 65, followed by gait disturbance and dysphagia. Neurological examination at age 67 disclosed pseudobulbar palsy, spastic gait, hyperreflexia, and presence of bilateral Hoffmann and Babinski signs. However, muscle atrophy, weakness, evidence of denervation on electromyography, vertical gaze palsy, parkinsonism, gait freezing, aphasia, speech apraxia, or dementia was not noted throughout the course. She was clinically diagnosed as having motor neuron disease consistent with so-called primary lateral sclerosis. Pathological examination disclosed histopathological features of PSP, including argyrophilic and tau-positive tufted astrocytes, neurofibrillary tangles, coiled bodies, and thread-like processes in the motor cortex and superior frontal gyrus, and to a lesser degree, in the basal ganglia and brain stem nuclei. In addition, severe fibrillary gliosis was noted in the precentral gyrus and corticospinal tract, being consistent with upper motor neuron syndrome observed in this case. No TAR-DNA binding protein 43-positive lesion, FUS pathology, Bunina body, or Lewy body-like hyaline inclusion was noted in the motor cortex or lower motor neurons. These findings suggest that when tau pathology is prominent in the motor cortex but is minimal in the basal ganglia and brain stem nuclei, a PSP case can lack all classic clinical features of PSP and show only slowly progressive upper motor syndrome, consistent with clinical picture of primary lateral sclerosis. Copyright © 2012 Elsevier B.V. All rights reserved.

Conference on ground-mounted photovoltaic plants in France and in Germany

International Nuclear Information System (INIS)

Viertl, Cornelia; Argenlieu, Philippe d'; Masson, Gaetan; Schwan, Kurt; Thomas, Christophe; Hoffmann, Uta; Bohl, Johannes; Gossement, Arnaud; Jaclot, Emmanuel

2015-01-01

The French-German office for Renewable energies (OFAEnR) organised a conference on the future of ground-mounted photovoltaic plants both in France and Germany. In the framework of this French-German exchange of experience, about 130 participants debated about the present day and future regulatory framework and about the opportunities and challenges for projects financing and electricity resale. The different steps of plants realisation, from the planning to the site selection, the construction and the environmental issues were addressed as well. This document brings together the available presentations (slides) made during this event: 1 - Introduction of PV tendering within the context of a premium system (Cornelia Viertl); 2 - Ground-mounted solar plants - evolution of the Legal and Regulatory framework in France - New calls for tender (Philippe d'Argenlieu); 3 - Competitiveness of Utility-Scale PV (Gaetan Masson); 4 - Power production by ground-mounted PV systems for nearby industrial parks (Kurt Schwan); 5 - experience feedback of a direct selling operator and the future role of direct solar power selling (Christophe Thomas); 6 - Financing solar plants via crowd-funding - opportunities and challenges (Uta Hoffmann); 7 - The Planning and approval Process in Germany: Potential for Standardization and Optimization? (Johannes Bohl); 8 - Planning and approval Procedures in France: towards an harmonization between the different competent authorities and a reduction of the periods allowed for appeals? (Arnaud Gossement); 9 - EDF Energies Nouvelles: Solar plant of the Base of Toul-Rosieres. Decontamination and valorisation of polluted sites thanks to the construction of ground-mounted plants (Emmanuel Jaclot)

Hindlimb spasticity after unilateral motor cortex lesion in rats is reduced by contralateral nerve root transfer.

Science.gov (United States)

Zong, Haiyang; Ma, Fenfen; Zhang, Laiyin; Lu, Huiping; Gong, Jingru; Cai, Min; Lin, Haodong; Zhu, Yizhun; Hou, Chunlin

2016-12-01

Lower extremity spasticity is a common sequela among patients with acquired brain injury. The optimum treatment remains controversial. The aim of our study was to test the feasibility and effectiveness of contralateral nerve root transfer in reducing post stroke spasticity of the affected hindlimb muscles in rats. In our study, we for the first time created a novel animal hindlimb spastic hemiplegia model in rats with photothrombotic lesion of unilateral motor cortex and we established a novel surgical procedure in reducing motor cortex lesion-induced hindlimb spastic hemiplegia in rats. Thirty six rats were randomized into three groups. In group A, rats received sham operation. In group B, rats underwent unilateral hindlimb motor cortex lesion. In group C, rats underwent unilateral hindlimb cortex lesion followed by contralateral L4 ventral root transfer to L5 ventral root of the affected side. Footprint analysis, Hoffmann reflex (H-reflex), cholera toxin subunit B (CTB) retrograde tracing of gastrocnemius muscle (GM) motoneurons and immunofluorescent staining of vesicle glutamate transporter 1 (VGLUT1) on CTB-labelled motoneurons were used to assess spasticity of the affected hindlimb. Sixteen weeks postoperatively, toe spread and stride length recovered significantly in group C compared with group B (Pmotor cortex lesion-induced hindlimb spasticity in rats. Our data indicated that this could be an alternative treatment for unilateral lower extremity spasticity after brain injury. Therefore, contralateral neurotization may exert a potential therapeutic candidate to improve the function of lower extremity in patients with spastic hemiplegia. © 2016 The Author(s).

Mesenteric cryptococcal granuloma in a dog caused by Cryptococcus neoformans var. grubii

Directory of Open Access Journals (Sweden)

Rodrigues-Hoffmann A

2012-09-01

Full Text Available Jennifer R Cook, Karen E Russell, Kristin B Eden, Aline Rodrigues-HoffmannDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USAAbstract: Although cryptococcosis is usually associated with respiratory and neurologic signs in domestic species (such as sneeze, cough, nasal discharge, seizures, ataxia, clinical manifestations of the disease may be more subtle and nonspecific. A 3-year-old male castrated Boxer dog presented with a history of chronic vomiting, diarrhea, weight loss, and lethargy. At no time had respiratory or neurologic signs been noted by the owners or the primary care veterinarian. Palpation of an abdominal mass revealed an atypical lesion location: a large (16 × 9 × 7 cm mass at the root of the mesentery. Diagnosis was achieved through cytology of this mass and a positive serologic Cryptococcus capsular antigen titer; polymerase chain reaction was utilized for speciation of the abdominal isolate as Cryptococcus neoformans variety grubii. The animal was euthanized due to poor prognosis. After necropsy and histopathologic analysis, the mesenteric mass and associated lymph nodes were identified as large fungal granulomas. This is a rare manifestation of cryptococcosis, involving several visceral organs, with no remaining evidence of the route of entry of the organism. As prompt diagnosis of mycotic illness is paramount to successful management, this case indicates that cryptococcal infection should be considered as a differential diagnosis in dogs with gastrointestinal signs and lymphadenopathy. The protean nature of cryptococcosis is discussed within the context of a brief review of emerging and unresolved issues in pathogenesis.Keywords: Cryptococcus gattii, granuloma, lymphadenitis

Computed tomography of the skeletal muscles in neuromuscular diseases

International Nuclear Information System (INIS)

Nagao, Hideo; Takahashi, Mitsugi; Habara, Shinji; Nagai, Yoshinao; Matsuda, Hiroshi

1986-01-01

Computed tomographic (CT) scans of the shoulder girdle, upper arm, waist, pelvic girdle, thigh, and lower leg were obtained in a total of 21 patients with neuromuscular diseases, including 10 with Duchenne muscle dystrophy (DMD), 3 with Fukushima type congenital muscular dystrophy (FCMD), 3 with Werdnig-Hoffmann's disease (WH), 3 with autosomal recessive muscular dystrophy in childhood (childhood MC), one with nemaline myopathy (NM), and one with myositis ossificans circumscripta (MOC). Age-dependent changes in CT findings were examined in the 10 DMD patients ranging in age from 3 to 15 years. Each muscle of the shoulder girdle and upper arm was seen as a low density area on CT in patients 9 years of age when the arms are difficult to elevate. Changes in the m. quadriceps femoris occurring in all the patients were visible earlist on CT, followed by those in the m. gluteus maximus, m. gastrocnemius, and m. soleus. CT scans of the thigh was thus considered most useful in diagnosing DMD. CT scans of the lower leg showed low density areas in the m. gastrocnemius and m. soleus in both WH and FCMD patients, while a low density area seen in the m. gluteus maximum on CT was restricted to FCMD patients. This suggests the potential of CT in the differentiation of WH from FCMD. In patients with childhood ARMD, there were various CT findings including normal and extremely low density areas. CT findings in NM patients were similar to those in DMD patients. High density areas were seen along the fascia of the trunk in MOC patients. (Namekawa, K.)

Effect of air-abrasion on the retention of zirconia ceramic crowns luted with different cements before and after artificial aging.

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Shahin, Ramez; Kern, Matthias

2010-09-01

The purpose of this in vitro study was to evaluate the effect of intaglio surface air-abrasion on the retention of CAD/CAM produced zirconia ceramic crowns cemented with three different types of cement. In addition the influence of artificial aging in masticatory simulator and thermocycling was tested. Extracted human premolars were prepared for all-ceramic crowns (12 degrees taper, 3 mm axial length). CAD/CAM zirconia crowns were manufactured. Half of the crowns were air-abraded with 50 microm alumina particles at 0.25 MPa, the rest was left as machined. The crowns were luted with zinc phosphate cement (Hoffmann), glass ionomer cement (Ketac Cem), or composite resin (Panavia 21), subgroups were either stored for 3 days in 37 degrees water bath or stored for 150 days in 37 degrees water bath, with additional 37,500 thermal cycles (5-55 degrees) and 300,000 cycles dynamic loading with 5 kg in a masticatory simulator. Then crown retention was measured in tension at a crosshead speed of 2 mm/min using a universal testing machine. Statistical analysis was performed with three-way ANOVA. Mean retention values were ranged from 2.8 to 7.1 MPa after 3 days and from 1.6 to 6.1 MPa after artificial aging. Air-abrasion significantly increased crown retention (partificial aging decreased retention (p=0.017). In addition, the luting material had a significant influence on retention (p<0.001) with the adhesive luting resin providing the highest retention. The use of phosphate monomer containing composite resin on air-abraded zirconia ceramic can be recommended as most retentive luting method. Copyright 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Inovação tecnológica na indústria farmacêutica: diferenças entre a Europa, os EUA e os países farmaemergentes

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Alessandra Cristina Santos Akkari

2016-01-01

Full Text Available Resumo Historicamente, o cenário farmacêutico mundial tem sido dominado por grandes multinacionais (Big Pharma, majoritariamente de origem europeia e norte-americana. Contudo, é consenso na literatura a importância crescente dos mercados farmacêuticos emergentes (países farmaemergentes, especialmente China e Brasil, que são vistos como os maiores responsáveis pelo crescimento sustentável do segmento farmacêutico. Esse artigo teve como objetivo realizar um mapeamento tecnológico e industrial do setor farmacêutico, a partir de informações de bancos de dados patentários internacionais (WIPO e Derwent, entre 1996 até o último ano de registro (2013. Utilizando-se o Método dos Mínimos Quadrados e implementação de um algoritmo no MATLAB, desenvolveram-se previsões para o período 2014-2018. Os resultados obtidos atestaram a liderança da Europa e dos EUA no setor, destacando-se o índice de inovação da Hoffmann-La Roche; a participação expressiva da China; e a pouca contribuição do Brasil no âmbito mundial. Todavia, estimou-se uma tendência de crescimento acentuado no número de proteções concedidas ao Brasil (41% e à China (27%, apontando um alcance, até 2036, dos índices de patenteamento chineses aos números dos atuais líderes mundiais, trazendo a esperança da difusão tecnológica e científica e do aumento da competitividade no segmento farmacêutico.

A Study of Electrocyclic Reactions in a Molecular Junction: Mechanistic and Energetic Requirements for Switching in the Coulomb Blockade Regime.

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Olsen, Stine T; Brøndsted Nielsen, Mogens; Hansen, Thorsten; Ratner, Mark A; Mikkelsen, Kurt V

2017-06-20

Molecular photoswitches incorporated in molecular junctions yield the possibility of light-controlled switching of conductance due to the electronic difference of the photoisomers. Another isomerization mechanism, dark photoswitching, promoted by a voltage stimulus rather than by light, can be operative in the Coulomb blockade regime for a specific charge state of the molecule. Here we elucidate theoretically the mechanistic and thermodynamic restrictions for this dark photoswitching for donor-acceptor substituted 4n and 4n+2 π-electron open-chain oligoenes (1,3-butadiene and 1,3,5-hexatriene) by considering the molecular energies and orbitals of the molecules placed in a junction. For an electrocyclic ring closure reaction to occur for these compounds, we put forward two requirements: a) the closed stereoisomer (cis or trans form) must be of lower energy than the open form, and b) the reaction pathway must be in accordance to the orbital symmetry rules expressed by the Woodward-Hoffmann rules (when the electrodes do not significantly alter the molecular orbital appearances). We find these two requirements to be valid for the dianion of (1E,3Z,5E)-hexa-1,3,5-triene-1,6-diamine, and the Coulomb blockade diamonds were therefore modeled for this compound to elucidate how a dark photoswitching event would manifest itself in the stability plot. From this modeling of conductance as a function of gate and bias potentials, we predict a collapse in Coulomb diamond size, that is, a decrease in the height of the island of zero conductance. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

The rate of aucubin, a secondary metabolite in Plantago lanceolata and potential nitrification inhibitor, needed to reduce ruminant urine patch nitrous oxide emissions

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Gardiner, C. A.; Clough, T.; Cameron, K.; Di, H.; Edwards, G. R.

2017-12-01

Nitrous oxide (N2O) losses derived from grazing ruminant livestock urine patches account for 40% of global N2O emissions. It has been shown that Plantago lanceolata, an herb species used in grazed pastures, contains an active secondary metabolite (aucubin) that has the potential to be excreted by grazing ruminants and inhibit nitrification in the urine patch, a key step in soil N2O production. However, the urinary excretion rate of aucubin needed to significantly reduce urine patch N2O emissions remains unknown. Aucubin was dissolved in bovine urine at three rates (47, 243, and 486 kg ha-1), based on rates used in Dietz et al. (2013) and the calculated highest potential aucubin application rate, from Gardiner et al. (2017). A control, along with a urine treatment and the three aucubin treatments (all urine applied at 700 kg N ha-1), was applied to 20 g soil and incubated in the laboratory for 35 d. Soils were monitored for surface pH, inorganic N concentration (NH4+/NO3-), and gas (N2O and CO2) fluxes. This experiment is currently underway and the results will be presented at the conference. Dietz M, Machill S, Hoffmann H, Schmidtke K 2013. Inhibitory effects of Plantago lanceolata L. on soil N mineralization. Plant and Soil 368: 445-458. Gardiner CA, Clough TJ, Cameron KC, Di HJ, Edwards GR, de Klein CAM 2017. The potential inhibitory effects of Plantago lanceolata and its active secondary metabolite aucubin on soil nitrification and nitrous oxide emissions under ruminant urine patch conditions. Manuscript submitted for publication.

Circular displays: control/display arrangements and stereotype strength with eight different display locations.

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Chan, Alan H S; Hoffmann, Errol R

2015-01-01

Two experiments are reported that were designed to investigate control/display arrangements having high stereotype strengths when using circular displays. Eight display locations relative to the operator and control were tested with rotational and translational controls situated on different planes according to the Frame of Reference Transformation Tool (FORT) model of Wickens et al. (2010). (Left. No, Right! Development of the Frame of Reference Transformation Tool (FORT), Proceedings of the Human Factors and Ergonomics Society 54th Annual Meeting, 54: 1022-1026). In many cases, there was little effect of display locations, indicating the importance of the Worringham and Beringer (1998. Directional stimulus-response compatibility: a test of three alternative principles. Ergonomics, 41(6), 864-880) Visual Field principle and an extension of this principle for rotary controls (Hoffmann and Chan (2013). The Worringham and Beringer 'visual field' principle for rotary controls. Ergonomics, 56(10), 1620-1624). The initial indicator position (12, 3, 6 and 9 o'clock) had a major effect on control/display stereotype strength for many of the six controls tested. Best display/control arrangements are listed for each of the different control types (rotational and translational) and for the planes on which they are mounted. Data have application where a circular display is used due to limited display panel space and applies to space-craft, robotics operators, hospital equipment and home appliances. Practitioner Summary: Circular displays are often used when there is limited space available on a control panel. Display/control arrangements having high stereotype strength are listed for four initial indicator positions. These arrangements are best for design purposes.

Does spinal excitability scale to the difficulty of the dual-task?

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Day, Devon M; Boivin, Mario T; Adkin, Allan L; Tokuno, Craig D

2017-08-01

This study examined whether spinal excitability, as measured by the soleus Hoffmann reflex (H-reflex), is scaled to the difficulty level of the dual-task being performed. Twenty-two participants completed a combination of three balance task and three secondary cognitive (visuo-motor) task difficulty levels for a total of nine dual-task conditions. An additional eight participants were tested while performing the same three balance task difficulty levels on its own (i.e., single-tasking). The balance task required participants to maintain their balance on a fixed or rotating stabilometer while the visuo-motor task required participants to respond to moving targets presented on a monitor. Throughout each single- and dual-task trial, H-reflexes were elicited from the soleus. Although dual-task performance, as quantified by visuo-motor task accuracy as well as the root mean square of the stabilometer position and velocity, decreased by 10-34% with increasing dual-task difficulty (p dual-task conditions (p = 0.483-0.758). This contrasts to when participants performed the balance task as a single-task, where the H-reflex amplitude decreased by ~25% from the easy to the hard balance task difficulty level (p = 0.037). In contrast to the commonly reported finding of a reduced soleus H-reflex amplitude when individuals perform a less posturally stable task by itself, the results indicate that spinal excitability is not modulated as a function of dual-task difficulty. It is possible that when an individual's attentional resource capacity is exceeded during dual-tasking, they become ineffective in regulating spinal excitability for balance control.

Cervical Hemilaminoplasty with Miniplates in Long Segment Intradural Extramedullary Ependymoma: Case Report and Technical Note.

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Oral, Sukru; Tumturk, Abdulfettah; Kucuk, Ahmet; Menku, Ahmet

2018-01-01

The surgical approaches for spinal tumors, to a great extent, have been developed in accordance with the developments in medical technology. Today, many surgical techniques are implemented as anterior, anterolateral, posterior, posterolateral and combined approaches. Due to its low morbidity, the posterior approach is the more preferred one. Laminectomy is a widely used technique, especially in neoplastic lesions. However, following laminectomy, there are numerous complications such as instability, kyphotic deformity and scar formation. In this paper, the excision of a tumor that was located intradural-extramedullary at the C3-C7 level with the cervical hemilaminoplasty technique is described. A 47-year-old female patient presented to our clinic with increasing complaints of neck and left arm pain, left arm numbness and searing pain for the last 10 years. On examination, hypoesthesia at the C4-7 dermatomes in the left upper extremity, an increase in deep tendon reflexes, and bilateral positive Hoffmann reflexes were observed. C3-C7 laminae were opened unilaterally on the right side with a midline skin incision. The laminae were drilled with a high-speed drill to provide a wide opening, both on the midline obliquely and from the border of the lamina-facet joint. After the tumor was totally excised, hemilaminae were placed into the previous position and reconstructed with mini-plates and screws. Cervical hemilaminoplasty provides a wide field of vision in tumor surgery of this region. Besides, the reconstruction of hemilaminae is important for stability. As the integrity of the spinal canal is preserved during reoperations of this region, the risk of complications is decreased.

Pile Model Tests Using Strain Gauge Technology

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Krasiński, Adam; Kusio, Tomasz

2015-09-01

Ordinary pile bearing capacity tests are usually carried out to determine the relationship between load and displacement of pile head. The measurement system required in such tests consists of force transducer and three or four displacement gauges. The whole system is installed at the pile head above the ground level. This approach, however, does not give us complete information about the pile-soil interaction. We can only determine the total bearing capacity of the pile, without the knowledge of its distribution into the shaft and base resistances. Much more information can be obtained by carrying out a test of instrumented pile equipped with a system for measuring the distribution of axial force along its core. In the case of pile model tests the use of such measurement is difficult due to small scale of the model. To find a suitable solution for axial force measurement, which could be applied to small scale model piles, we had to take into account the following requirements: - a linear and stable relationship between measured and physical values, - the force measurement accuracy of about 0.1 kN, - the range of measured forces up to 30 kN, - resistance of measuring gauges against aggressive counteraction of concrete mortar and against moisture, - insensitivity to pile bending, - economical factor. These requirements can be fulfilled by strain gauge sensors if an appropriate methodology is used for test preparation (Hoffmann [1]). In this paper, we focus on some aspects of the application of strain gauge sensors for model pile tests. The efficiency of the method is proved on the examples of static load tests carried out on SDP model piles acting as single piles and in a group.

Numerical simulation of convective generated gravity waves in the stratosphere and MLT regions.

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Heale, C. J.; Snively, J. B.

2017-12-01

Convection is an important source of gravity wave generation, especially in the summer tropics and midlatitudes, and coherent wave fields above convection are now routinely measured in the stratosphere and mesosphere [e.g. Hoffmann et al., JGR, 118, 2013; Gong et al., JGR, 120, 2015; Perwitasari et al., GRL, 42, 22, 2016]. Numerical studies have been performed to investigate the generation mechanisms, source spectra, and their effects on the middle and upper atmosphere [e.g. Fovell et al., AMS, 49,16, 1992; Alexander and Holton, Atmos. Chem. Phys., 4 2004; Vincent et al., JGR, 1118, 2013], however there is still considerable work needed to fully describe these parameters. GCMs currently lack the resolution to explicitly simulate convection generation and rely on simplified parameterizations while full cloud resolving models are computationally expensive and often only extend into the stratosphere. More recent studies have improved the realism of these simulations by using radar derived precipitation rates to drive latent heating in models that simulate convection [Grimsdell et al., AMS, 67, 2010; Stephan and Alexander., J. Adv. Model. Earth. Syst, 7, 2015], however they too only consider wave propagation in the troposphere and stratosphere. We use a 2D nonlinear, fully compressible model [Snively and Pasko., JGR, 113, 2008] to excite convectively generated waves, based on NEXRAD radar data, using the Stephan and Alexander [2015] algorithms. We study the propagation, and spectral evolution of the generated waves up into the MLT region. Ambient atmosphere parameters are derived from observations and MERRA-2 reanalysis data, and stratospheric (AIRS) and mesospheric (Lidar, OH airglow) observations enable comparisons with simulation results.

Prevalence and risk factors for giardiasis and soil-transmitted helminthiasis in three municipalities of Southeastern Minas Gerais State, Brazil: risk factors for giardiasis and soil-transmitted helminthiasis.

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Pinheiro, Izabella de Oliveira; de Castro, Milton Ferreira; Mitterofhe, Adalberto; Pires, Flávia Alves Condé; Abramo, Clarice; Ribeiro, Luiz Cláudio; Tibiriçá, Sandra Helena Cerrato; Coimbra, Elaine Soares

2011-05-01

Giardiasis and soil-transmitted helminthiasis (STH) are parasitic diseases that are among the major health concerns observed in economically disadvantaged populations of developing countries, and have clear social and environmental bases. In Brazil, there is a lack of epidemiologic data concerning these infections in the study area, whose inhabitants have plenty of access to health care services, including good dwelling and adequate sanitary conditions. In this survey we investigated the risk factors for giardiasis and STH in three municipalities with good sanitation, situated in Minas Gerais state, Brazil. A cross-sectional survey was conducted in the municipalities of Piau, Coronel Pacheco and Goianá, in both urban and rural areas. The fieldwork consisted of a questionnaire and the examination of 2,367 stool samples using the Hoffmann, Pons and Janer method. Of all individuals from the population sample, 6.1% were found infected with the parasitic diseases included in this work. Hookworm infection was the most prevalent disease, followed by giardiasis, trichuriasis and ascariasis. Infection was more prevalent in males (8.1%, p < 0.001; odds ratio [OR] = 1.975) and in individuals living in rural areas (8.6%, p = 0.003; OR = 1.693). Multivariate analysis showed that variables such as inadequate sewage discharge (p < 0.001), drinking of unsafe water (p < 0.001), lack of sanitary infrastructure (p = 0.015), and host sex (p < 0.001) were the risk factors more strongly associated with infection status (95% confidence interval [CI]). In this study we demonstrate that giardiasis and STH still persist, infecting people who have good housing conditions and free access to public health care and education.

Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP

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Galic, Sandra; Hauser, Christine; Kahn, Barbara B.; Haj, Fawaz G.; Neel, Benjamin G.; Tonks, Nicholas K.; Tiganis, Tony

2005-01-01

The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes. Our previous studies have shown that the closely related tyrosine phosphatase TCPTP might also contribute to the regulation of insulin receptor (IR) signaling in vivo (S. Galic, M. Klingler-Hoffmann, M. T. Fodero-Tavoletti, M. A. Puryer, T. C. Meng, N. K. Tonks, and T. Tiganis, Mol. Cell. Biol. 23:2096-2108, 2003). Here we show that PTP1B and TCPTP function in a coordinated and temporally distinct manner to achieve an overall regulation of IR phosphorylation and signaling. Whereas insulin-induced phosphatidylinositol 3-kinase/Akt signaling was prolonged in both TCPTP−/− and PTP1B−/− immortalized mouse embryo fibroblasts (MEFs), mitogen-activated protein kinase ERK1/2 signaling was elevated only in PTP1B-null MEFs. By using phosphorylation-specific antibodies, we demonstrate that both IR β-subunit Y1162/Y1163 and Y972 phosphorylation are elevated in PTP1B−/− MEFs, whereas Y972 phosphorylation was elevated and Y1162/Y1163 phosphorylation was sustained in TCPTP−/− MEFs, indicating that PTP1B and TCPTP differentially contribute to the regulation of IR phosphorylation and signaling. Consistent with this, suppression of TCPTP protein levels by RNA interference in PTP1B−/− MEFs resulted in no change in ERK1/2 signaling but caused prolonged Akt activation and Y1162/Y1163 phosphorylation. These results demonstrate that PTP1B and TCPTP are not redundant in insulin signaling and that they act to control both common as well as distinct insulin signaling pathways in the same cell. PMID:15632081

The Complexity of H-wave Amplitude Fluctuations and Their Bilateral Cross-Covariance Are Modified According to the Previous Fitness History of Young Subjects under Track Training

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Maria E. Ceballos-Villegas

2017-11-01

Full Text Available The Hoffmann reflex (H-wave is produced by alpha-motoneuron activation in the spinal cord. A feature of this electromyography response is that it exhibits fluctuations in amplitude even during repetitive stimulation with the same intensity of current. We herein explore the hypothesis that physical training induces plastic changes in the motor system. Such changes are evaluated with the fractal dimension (FD analysis of the H-wave amplitude-fluctuations (H-wave FD and the cross-covariance (CCV between the bilateral H-wave amplitudes. The aim of this study was to compare the H-wave FD as well as the CCV before and after track training in sedentary individuals and athletes. The training modality in all subjects consisted of running three times per week (for 13 weeks in a concrete road of 5 km. Given the different physical condition of sedentary vs. athletes, the running time between sedentary and athletes was different. After training, the FD was significantly increased in sedentary individuals but significantly reduced in athletes, although there were no changes in spinal excitability in either group of subjects. Moreover, the CCV between bilateral H-waves exhibited a significant increase in athletes but not in sedentary individuals. These differential changes in the FD and CCV indicate that the plastic changes in the complexity of the H-wave amplitude fluctuations as well as the synaptic inputs to the Ia-motoneuron systems of both legs were correlated to the previous fitness history of the subjects. Furthermore, these findings demonstrate that the FD and CCV can be employed as indexes to study plastic changes in the human motor system.

Perceived parenting and social support: can they predict academic achievement in Argentinean college students?

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de la Iglesia G

2014-09-01

Full Text Available Guadalupe de la Iglesia,1,2 Agustin Freiberg Hoffmann,2 Mercedes Fernández Liporace1,2 1National Council of Scientific and Technical Research (CONICET, 2University of Buenos Aires, Buenos Aires, Argentina Abstract: The aim of this study was to test the ability to predict academic achievement through the perception of parenting and social support in a sample of 354 Argentinean college students. Their mean age was 23.50 years (standard deviation =2.62 years and most of them (83.3% were females. As a prerequisite for admission to college, students are required to pass a series of mandatory core classes and are expected to complete them in two semesters. Delay in completing the curriculum is considered low academic achievement. Parenting was assessed taking into account the mother and the father and considering two dimensions: responsiveness and demandingness. Perceived social support was analyzed considering four sources: parents, teachers, classmates, and best friend or boyfriend/girlfriend. Path analysis showed that, as hypothesized, responsiveness had a positive indirect effect on the perception of social support and enhanced achievement. Demandingness had a different effect in the case of the mother as compared to the father. In the mother model, demandingness had a positive direct effect on achievement. In the case of the father, however, the effect of demandingness had a negative and indirect impact on the perception of social support. Teachers were the only source of perceived social support that significantly predicted achievement. The pathway that belongs to teachers as a source of support was positive and direct. Implications for possible interventions are discussed. Keywords: academic achievement, parenting, social support, college

The Complexity of H-wave Amplitude Fluctuations and Their Bilateral Cross-Covariance Are Modified According to the Previous Fitness History of Young Subjects under Track Training.

Science.gov (United States)

Ceballos-Villegas, Maria E; Saldaña Mena, Juan J; Gutierrez Lozano, Ana L; Sepúlveda-Cañamar, Francisco J; Huidobro, Nayeli; Manjarrez, Elias; Lomeli, Joel

2017-01-01

The Hoffmann reflex (H-wave) is produced by alpha-motoneuron activation in the spinal cord. A feature of this electromyography response is that it exhibits fluctuations in amplitude even during repetitive stimulation with the same intensity of current. We herein explore the hypothesis that physical training induces plastic changes in the motor system. Such changes are evaluated with the fractal dimension (FD) analysis of the H-wave amplitude-fluctuations (H-wave FD) and the cross-covariance (CCV) between the bilateral H-wave amplitudes. The aim of this study was to compare the H-wave FD as well as the CCV before and after track training in sedentary individuals and athletes. The training modality in all subjects consisted of running three times per week (for 13 weeks) in a concrete road of 5 km. Given the different physical condition of sedentary vs. athletes, the running time between sedentary and athletes was different. After training, the FD was significantly increased in sedentary individuals but significantly reduced in athletes, although there were no changes in spinal excitability in either group of subjects. Moreover, the CCV between bilateral H-waves exhibited a significant increase in athletes but not in sedentary individuals. These differential changes in the FD and CCV indicate that the plastic changes in the complexity of the H-wave amplitude fluctuations as well as the synaptic inputs to the Ia-motoneuron systems of both legs were correlated to the previous fitness history of the subjects. Furthermore, these findings demonstrate that the FD and CCV can be employed as indexes to study plastic changes in the human motor system.

Growth and nutrition of Tetraclinis articulata (Vahl Mast. cultivated in different rhizosphere soils collected from Tetraclinis stand

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Abbas, Y.

2013-01-01

Full Text Available Five representative plant species (Withania frutescens Pauquy, Lavandula multifida L., Pistacia atlantica Desf., Olea europaea L. subsp. oleaster (Hoffmanns. & Link Negodi and Tetraclinis articulata [Vahl] Mast. were selected from Moroccan Tetraclinis woodland in order to evaluate their mycorrhizal potential and to compare the impact of their rhizosphere soil on growth and nutrition of Tetraclinis articulata seedlings. We observed that roots of selected plants were highly colonized by Arbuscular Mycorrhizal (AM fungi. Lavandula multifida roots showed the highest colonization percentage (100%. We recovered AM fungal spores from the rhizosphere soils of the five plant species and we found that the spores number from L. multifida and T. articulata rhizosphere was significantly different from that of other plants. We assessed the mycorrhizal potential of the indigenous soils by using the Most Probable Number (MPN approach. We found that MPN in soils collected near the five plant species was significantly higher than the one in the bare soil. The average of MPN per 100 g of dry soil was 11.8 (from 5.6 to 25.0 in the bare soil and 228.5 (from 108.0 to 476.0 in L. multifida rhizosphere. This result indicates that the soil surrounding the target plants can be used as inoculum for mycorrhization. We conducted a nursery experiment in which L. multifida soil yielded a high mycorrhizal percentage in T. articulata plants, thus contributing to improve the plant growth. However, the highest formation of arbuscules in T. articulata grown in Lavandula soil did not significantly affect the growth or the nutrition of plants compared to Tetraclinis soil, except for potassium concentration. Our investigation clearly showed that L. multifida soil can be used as biofertilizer to inoculate nurseries for T. articulata production. This will greatly contribute to sustain Tetraclinis woodland.

Numerical simulation of optical and electronic properties for multilayer organic light-emitting diodes and its application in engineering education

Science.gov (United States)

Chang, Shu-Hsuan; Chang, Yung-Cheng; Yang, Cheng-Hong; Chen, Jun-Rong; Kuo, Yen-Kuang

2006-02-01

Organic light-emitting diodes (OLEDs) have been extensively developed in the past few years. The OLED displays have advantages over other displays, such as CRT, LCD, and PDP in thickness, weight, brightness, response time, viewing angle, contrast, driving power, flexibility, and capability of self-emission. In this work, the optical and electronic properties of multilayer OLED devices are numerically studied with an APSYS (Advanced Physical Model of Semiconductor Devices) simulation program. Specifically, the emission and absorption spectra of the Alq 3, DCM, PBD, and SA light-emitting layers, and energy band diagrams, electron-hole recombination rates, and current-voltage characteristics of the simulated OLED devices, typically with a multilayer structure of metal/Alq 3/EML/TPD/ITO constructed by Lim et al., are investigated and compared to the experimental results. The physical models utilized in this work are similar to those presented by Ruhstaller et al. and Hoffmann et al. The simulated results indicate that the emission spectra of the Alq 3, DCM, PBD, and SA light-emitting layers obtained in this study are in good agreement with those obtained experimentally by Zugang et al. Optimization of the optical and electronic performance of the multilayer OLED devices are attempted. In order to further promote the research results, the whole numerical simulation process for optimizing the design of OLED devices has been applied to a project-based course of OLED device design to enhance the students' skills in photonics device design at the Graduate Institute of Photonics of National Changhua University of Education in Taiwan. In the meantime, the effectiveness of the course has been proved by various assessments. The application of the results is a useful point of reference for the research on photonics device design and engineering education. Therefore, it proffers a synthetic effect between innovation and practical application.

«Let the theory guide our development»

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Antonio E. Puente

2016-03-01

Full Text Available The interview presents the American Psychological Association (APA and the activities of Antonio E. Puente (Antonio E. Puente, Ph.D., as the President of this organization. Antonio Puente, Ph.D., Professor of Psychology at the University of North Carolina (UNCW, Wilmington, was elected president of the APA in 2017.When asked about the main directions of the future work of the American Psychological Association, Antonio Puente, drew attention to the need for dramatically restructuring the work of the largest scientific and professional organization. It is caused by past investigation and Hoffmann report. After the terrorist attacks of 2009, some psychologists (not APA members helped the CIA to obtain information using torture. Changes in the APA will apply not only to the budget and staff, but also its mission, goals and values.Antonio Puente, following Michael Wertheimer believes that to evaluate the significance of certain modern discoveries is very difficult in the field of psychology. It will be possible to make a new generation of professionals. He sees neuropsychology as priority sector, which is considered by Antonio Puente the basis of all psychology as a science. According to A. Puente the most promising area of psychology application is health care. Using psychological science in health care should be more efficient and cost-effective. This approach extends the value of psychology and contributes to improving clinical outcomes and reducing costs.Speaking of the most famous Russian psychologist, A. Puente highlighted L.S. Vygotsky whose work he considers extremely important. Antonio Puente expresses regret that the modern world is observing the highest figures of murders and suicides, mass shooting, and mental disorders. Therefore, psychologists have to admit they have not arrived to a final understanding of the psychological characteristics of the person.

Intestinal parasitosis and socio-environmental factor sof a population from peri-urban area of Manaus - AM - doi: 10.5020/18061230.2010.p30

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Cecília Leite Motta de Oliveira

2012-01-01

Full Text Available Objectives: To describe the prevalence of intestinal parasitosis in patients who sought a Basic Health Unit and get to know the conditions and socio-environmental characteristics of a population of peri-urban area of Manaus - AM, Brazil. Methods: A study conducted by spontaneous demand of patients in a Basic Health Unit, Northern Zone of Manaus, Amazonas, between April and July 2007, conducting parasitological examination in 400 stool samples by Hoffmann-Pons-Janer’s method, and interviews. Results: From the total, 271/400 (67,8% contained parasites; 181/268 (45,25% samples were of females; 147/224 (36,7% aged between 19 and 85 years; 119/170 (29,75% with incomplete elementary school; 207/299 (51.75% with a family income between one and three minimum wages; 220/316 (55% were natural from Amazonas; 192/284 (48% worked at home; 199/298 (49,7% consumed water from artesian public well; 106/152 (26.5% treated the water; 165/248 (66% did not treat the consumed water. The most frequent helminthes found: Ascaris lumbricoides 48 (12%, Enterobius vermicularis 44 (11%, Ancilostomídeos 38 (9,5%. Protozoa: Entamoeba histolytica 83 (20,8%, Entamoeba coli and Endolimax nana, 79 (19,8% e 79 (19,8% respectively, Giardia lamblia 41 (10,3% and Iodamoeba butschlii 17 (4,3%. It was observed monoparasitism for E. histolytica 83 (20,8%, biparasitism 104/271 (26% E. histolytica and A. lumbricóides, E. histolytica and E. vermicularis, E. histolytica and G. lamblia. Conclusions:   We recorded a high prevalence of parasites in young people with low income, low cultural level, predominantly women of the household. Among the environmental factors associated with these indexes are a deficiency in water services and sanitary sewer.

Avaliação epidemiológica de doenças negligenciadas em escolares: filariose linfática e parasitoses intestinais

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Ana M. Aguiar-Santos

2013-06-01

Full Text Available OBJETIVO: Descrever a prevalência de infecção filarial e de parasitoses intestinais em escolares numa área endêmica de filariose e refletir sobre a opção terapêutica utilizada no Brasil no tratamento coletivo para filariose. MÉTODOS: Estudo transversal envolvendo 508 alunos na faixa etária de 5-18 anos cadastrados em escolas públicas do município de Olinda-PE. Realizou-se a investigação da parasitose intestinal em três amostras de fezes, analisadas pelo método de Hoffmann, Pons e Janer. A investigação filarial foi feita com teste antigênico pela técnica de imunocromatográfica rápida (ICT e pesquisa de microfilárias, utilizando filtração em membrana de policarbonato. Para análise de dados utilizou-se a estatística descritiva através do programa EpiInfo versão 7. RESULTADOS: A prevalência de filariose por ICT foi de 13,8% e por microfilaremia de 1,2%, enquanto a de parasitoses intestinais foi 64,2%. A concomitância do diagnóstico filarial e de parasitoses intestinais foi de 9,4% e, 31,5% eram isentos de ambas as parasitoses. Entre os indivíduos com parasitoses intestinais, 55% eram monoparasitados e 45% poliparasitados. A presença de geohelmintos ocorreu em 72,5% dos parasitados. No grupo com infecção filarial a ocorrência de geohelmintíase foi de 54,5%. CONCLUSÕES: O diagnóstico simultâneo de infecção filarial e parasitose intestinal, bem como a elevada frequência de geohelmintos justificam uma reavaliação da estratégia terapêutica do tratamento coletivo no programa de filariose no Brasil.

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling

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Gregory E. P. Pearcey

2017-12-01

Full Text Available Spinal cord excitability, as assessed by modulation of Hoffmann (H- reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling. Presynaptic inhibition of Ia terminals is believed to contribute to this suppression of spinal cord excitability. Electrical stimulation to cutaneous nerves reduces Ia presynaptic inhibition, which facilitates spinal cord excitability, and this facilitation is present during arm cycling. Although it has been suggested that reducing presynaptic inhibition may prolong fatiguing contractions, it is unknown whether sensory stimulation can alter the effects of fatiguing exercise on performance or spinal cord excitability. Thus, the aim of this experiment was to determine if sensory stimulation can interfere with fatigue-related suppression of spinal cord excitability, and alter fatigue rates during cycling sprints. Thirteen participants randomly performed three experimental sessions that included: unloaded cycling with sensory stimulation (CONTROL + STIM, sprints with sensory stimulation (SPRINT + STIM and sprints without stimulation (SPRINT. Seven participants also performed a fourth session (CONTROL, which consisted of unloaded cycling. During SPRINT and SPRINT + STIM, participants performed seven, 10 s cycling sprints interleaved with 3 min rest. For CONTROL and CONTROL + STIM, participants performed unloaded cycling for ~30 min. During SPRINT + STIM and CONTROL + STIM, participants received patterned sensory stimulation to nerves of the right foot. H-reflexes and M-waves of the right soleus were evoked by stimulation of the tibial nerve at multiple time points throughout exercise. Sensory stimulation facilitated soleus H-reflexes during unloaded cycling, whereas sprints suppressed soleus H-reflexes. While receiving sensory stimulation, there was less suppression of soleus H-reflexes and slowed reduction in average power output

A global climatology of stratospheric gravity waves from Atmospheric Infrared Sounder observations

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Hoffmann, Lars; Xue, Xianghui; Alexander, M. Joan

2014-05-01

We present the results of a new study that aims on the detection and classification of `hotspots' of stratospheric gravity waves on a global scale. The analysis is based on a nine-year record (2003 to 2011) of radiance measurements by the Atmospheric Infrared Sounder (AIRS) aboard NASA's Aqua satellite. We detect the presence of stratospheric gravity waves based on 4.3 micron brightness temperature variances. Our method is optimized for peak events, i.e., strong gravity wave events for which the local variance considerably exceeds background levels. We estimated the occurrence frequencies of these peak events for different seasons and time of day and used the results to find local maxima of gravity wave activity. In addition, we use AIRS radiances at 8.1 micron to simultaneously detect convective events, including deep convection in the tropics and mesoscale convective systems at mid latitudes. We classified the gravity waves according to their sources, based on seasonal occurrence frequencies for convection and by means of topographic data. Our study reproduces well-known hotspots of gravity waves, e.g., the mountain wave hotspots at the Andes and the Antarctic Peninsula or the convective hotspot during the thunderstorm season over the North American Great Plains. However, the high horizontal resolution of the AIRS observations also helped us to locate several smaller hotspots, which were partly unknown or poorly studied so far. Most of these smaller hotspots are found near orographic features like small mountain ranges, in coastal regions, in desert areas, or near isolated islands. This new study will help to select the most promising regions and seasons for future observational studies of gravity waves. Reference: Hoffmann, L., X. Xue, and M. J. Alexander, A global view of stratospheric gravity wave hotspots located with Atmospheric Infrared Sounder observations, J. Geophys. Res., 118, 416-434, doi:10.1029/2012JD018658, 2013.

A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers.

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Pan, Lin; Belloni, Paula; Ding, Han Ting; Wang, Jianshuang; Rubino, Christopher M; Putnam, Wendy S

2017-09-01

Pirfenidone film-coated tablets were developed to offer an alternative to the marketed capsule formulation. This study assessed the bioequivalence of the tablet and capsule formulations under fed and fasted states. A Phase I, open-label, randomized, four-treatment-period, four-sequence, crossover pharmacokinetics study (NCT02525484) was conducted. Each subject received an 801-mg single dose of pirfenidone as three 267-mg capsules or one 801-mg tablet under fasted and fed conditions. Pirfenidone plasma C max , AUC 0-t and AUC 0-∞ were used to assess bioequivalence. Forty-four subjects were randomized to treatment. The 801-mg tablet in the fasted state met bioequivalence criteria [90% confidence intervals (CI) 80.00-125.00%] for the GLSM ratios of natural log-transformed C max , AUC 0-t and AUC 0-∞ . Under fed conditions, the 801-mg tablet met the bioequivalence criteria for AUC 0-t and AUC 0-∞ , but slightly exceeded the bioequivalence criteria for the C max (90% CI of 108.26-125.60%). The tablet C max was approximately 17% higher than that of the capsules. In the fed state, the tablet C max , and both AUC 0-t and AUC 0-∞ were reduced by 39% and 17%, respectively, relative to the fasted state. The tablet and capsules had acceptable tolerability profiles. The pirfenidone 801-mg tablet met bioequivalence criteria when compared with three 267-mg capsules in the fasted state. The tablet C max was slightly higher relative to capsules in the fed state, but this is not expected to have a clinically meaningful impact on the benefit-risk profile of pirfenidone. This work was supported by F. Hoffmann-La Roche Ltd.

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling.

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Pearcey, Gregory E P; Noble, Steven A; Munro, Bridget; Zehr, E Paul

2017-01-01

Spinal cord excitability, as assessed by modulation of Hoffmann (H-) reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling. Presynaptic inhibition of Ia terminals is believed to contribute to this suppression of spinal cord excitability. Electrical stimulation to cutaneous nerves reduces Ia presynaptic inhibition, which facilitates spinal cord excitability, and this facilitation is present during arm cycling. Although it has been suggested that reducing presynaptic inhibition may prolong fatiguing contractions, it is unknown whether sensory stimulation can alter the effects of fatiguing exercise on performance or spinal cord excitability. Thus, the aim of this experiment was to determine if sensory stimulation can interfere with fatigue-related suppression of spinal cord excitability, and alter fatigue rates during cycling sprints. Thirteen participants randomly performed three experimental sessions that included: unloaded cycling with sensory stimulation ( CONTROL + STIM ), sprints with sensory stimulation ( SPRINT + STIM ) and sprints without stimulation ( SPRINT ). Seven participants also performed a fourth session ( CONTROL ), which consisted of unloaded cycling. During SPRINT and SPRINT + STIM, participants performed seven, 10 s cycling sprints interleaved with 3 min rest. For CONTROL and CONTROL + STIM , participants performed unloaded cycling for ~30 min. During SPRINT + STIM and CONTROL + STIM , participants received patterned sensory stimulation to nerves of the right foot. H-reflexes and M-waves of the right soleus were evoked by stimulation of the tibial nerve at multiple time points throughout exercise. Sensory stimulation facilitated soleus H-reflexes during unloaded cycling, whereas sprints suppressed soleus H-reflexes. While receiving sensory stimulation, there was less suppression of soleus H-reflexes and slowed reduction in average power output, compared

Quasi-solid polymer electrolytes using photo-cross-linked polymers. Lithium and divalent cation conductors and their applications

Energy Technology Data Exchange (ETDEWEB)

Ikeda, Shoichiro; Mori, Yoichi; Furuhashi, Yuri; Masuda, Hideki [Nagoya Inst. of Tech. (Japan). Dept. of Applied Chemistry; Yamamoto, Osamu [Mie Univ., Tsu (Japan). Dept. of Chemistry

1999-09-01

In this report, we will present the results on the photo-cross-linked poly-(ethylene glycol) diacrylate (PEGDA) based quasi-solid, i.e. gel, polymer electrolyte systems with lithium, magnesium and zinc trifluoromethanesulfonates [triflate; M{sup n}(CF{sub 3}SO{sub 3}){sub n}] and their preliminary applications to primary cells. The Celgard{sup trademark} membrane-impregnated electrolytes were prepared in the same manner as Abraham et al. [K.M. Abraham, M. Alamgir, D.K. Hoffmann, J. Electrochem. Soc. 142 (1995) 683]. The precursor solutions were composed of metal triflates, ethylene carbonate, propylene carbonate, and tetraethylene glycol diacrylate. The Celgard{sup trademark} aa3401 membrane was soaked overnight in the precursor solution, then clamped between two Pyrex glass plates and irradiated with UV light to form a gel electrolyte. The maxima of the conductivity obtained were 4.5 x 10{sup -4} S cm{sup -1} at 12 mol% for LiCF{sub 3}SO{sub 3}, 1.7 x 10{sup -4} S cm{sup -1} at 1 mol% for Mg(CF{sub 3}SO{sub 3}){sub 2}, and 2.1 x 10{sup -4} S cm{sup -1} at 4 mol% Zn(CF{sub 3}SO{sub 3}){sub 2} system, respectively. The Arrhenius plots of the conductivities are almost linear between 268 and 338 K with 15-25 kJ/mol of activation energy for conduction. The cell, li vertical stroke LiCF{sub 3}SO{sub 3}-SPE+Celgard{sup trademark} aa3401 vertical stroke (CH{sub 3}){sub 4}NI{sub 5}+acetylene black, showed 2.86 V of OCV and could discharge up to 25% with respect to the cathode active material at a discharging current of 0.075 mA/cm{sup 2}. (orig.)

Working Memory Capacity and Surgical Performance While Exposed to Mild Hypoxic Hypoxemia.

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Parker, Paul J; Manley, Andrew J; Shand, Ross; O'Hara, John P; Mellor, Adrian

2017-10-01

Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3000 m in Afghanistan (9843 ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5000 ft. Aeromedical teams frequently work in unpressurized environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members. Ten UK orthopedic surgeons were recruited and in a double blind randomized experimental protocol, were acutely exposed for 45 min to normobaric hypoxia [fraction of inspired oxygen (FIo2) ∼14.1%, equivalent to 3000 m (10,000 ft)] or normobaric normoxia (sea-level). Basic physiological parameters were recorded. Subjects completed validated tests of verbal working memory capacity (VWMC) and also applied an orthopedic external fixator (Hoffmann® 3, Stryker, UK) to a plastic tibia under test conditions. Significant hypoxia was induced with the reduction of FIo2 to ∼14.1% (Spo2 87% vs. 98%). No effect of hypoxia on VWMC was observed. The pin-divergence score (a measure of frame asymmetry) was significantly greater in hypoxic conditions (4.6 mm) compared to sea level (3.0 mm); there was no significant difference in the penetrance depth (16.9 vs. 17.2 mm). One hypoxic frame would have failed early. We believe that surgery at an altitude of 3000 m, when unacclimated individuals are acutely exposed to atmospheric hypoxia for 45 min, can likely take place without supplemental oxygen use but further work is required.Parker PJ, Manley AJ, Shand R, O'Hara JP, Mellor A. Working memory capacity and surgical performance while exposed to mild hypoxic hypoxemia. Aerosp Med Hum Perform. 2017; 88(10):918-923.

Societal savings in patients with advanced non-squamous non-small-cell lung cancer receiving bevacizumab-based versus non-bevacizumab-based treatments in France, Germany, Italy, and Spain

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Lister J

2012-10-01

Full Text Available Johanna Lister,1 Sanja Stanisic,1 Klaus Kaier,2 Christian Hagist,2 Dmitry Gultyaev,1 Stefan Walzer31Analytica LA-SER International Inc, Lörrach, Germany; 2Research Centre for Generational Contracts, University of Freiburg, Freiburg, Germany; 3F Hoffmann-La Roche Ltd, Pharmaceuticals Division, Basel, SwitzerlandBackground: The purpose of this study was to investigate the savings accrued using bevacizumab-based treatment for non-small-cell lung cancer from the societal perspective, taking only public costs into account, in France, Germany, Italy, and Spain.Methods: Societal costs were estimated by collecting and analyzing labor costs, carer costs, sickness benefits, disability benefits, and home care benefits. Cost inputs were derived from publicly available databases or from the published literature. Expert opinion was only used if no other source was available. Efficacy data from two randomized clinical trials were used. The time horizon in the health economic model was lifetime. Efficacy and costs were discounted by 3.5%. All main model parameters were tested in deterministic and probabilistic sensitivity analyses.Results: Mean incremental savings to society per patient ranged from €2277 in Italy to €4461 in Germany. The results were most sensitive to the change in proportion of patients working full-time and the proportion of patients who were able to return to work.Conclusion: This analysis shows that bevacizumab-based treatment in non-small-cell lung cancer is associated with more savings to society compared to standard chemotherapy in terms of increased productivity and decreased social benefits paid to patients who are able to work in France, Germany, Italy, and Spain.Keywords: non-small-cell lung cancer, bevacizumab, chemotherapy, economic model, France, Germany, Italy, Spain

Colloidal dispersions in external fields: from equilibrium to non-equilibrium

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Lowen, Hartmut

2010-03-01

Dispersions of colloidal particles are excellent model systems of classical statistical mechanics in order to understand the principles of self-organization processes. Using an external field (e.g. electric or magnetic field) the effective interaction between the colloidal particles can be tailored and the system can be brought into non-equilibrium in a controlled way. Glass formation after an ultrafast quench in a two-dimensional superparamagnetic binary colloidal mixture [1,2] will be discussed as well as lane [3,4,5,6,7] and band [8] formation in mixtures of charged suspensions and dusty plasmas driven by an electric field. [4pt] References:[0pt] [1] L. Assoud, F. Ebert, P. Keim, R. Messina, G. Maret, H. Lowen, Phys. Rev. Letters 102, 238301 (2009). [0pt] [2] L. Assoud, F. Ebert, P. Keim, R. Messina, G. Maret, H. Lowen, J. Phys.: Condensed Matter 21, 464114 (2009). [0pt] [3] J. Dzubiella, G. P. Hoffmann, H. Lowen, Phys. Rev. E 65, 021402 (1-8) (2002). [0pt] [4] M. E. Leunissen, C. G. Christova, A. P. Hynninen, C. P. Royall, A. I. Campbell, A. Imhof, M. Dijkstra, R. van Roij, A. van Blaaderen, Nature 437, 235 (2005). [0pt] [5] M. Rex, H. Lowen, Phys. Rev. E 75, 051402 (2007). [0pt] [6] M. Rex, C. P. Royall, A. van Blaaderen, H. Lowen, Lane formation in driven colloidal mixtures: is it continuous or discontinuous?, http://arxiv.org/abs/0812.0908 [0pt] [7] K. R. Sutterlin, A. Wysocki, A. V. Ivlev, C. Rath, H. M. Thomas, M. Rubin-Zuzic, W. J. Goedheer, V. E. Fortov, A. M. Lipaev, V. I. Molotkov, O. F. Petrov, G. E. Morfill, H. Lowen, Phys. Rev. Letters 102, 085003 (2009). [0pt] [8] A. Wysocki, H. Lowen, Phys. Rev. E 79, 041408 (2009).

Gait variability and motor control in people with knee osteoarthritis.

Science.gov (United States)

Alkjaer, Tine; Raffalt, Peter C; Dalsgaard, Helle; Simonsen, Erik B; Petersen, Nicolas C; Bliddal, Henning; Henriksen, Marius

2015-10-01

Knee osteoarthritis (OA) is a common disease that impairs walking ability and function. We compared the temporal gait variability and motor control in people with knee OA with healthy controls. The purpose was to test the hypothesis that the temporal gait variability would reflect a more stereotypic pattern in people with knee OA compared with healthy age-matched subjects. To assess the gait variability the temporal structure of the ankle and knee joint kinematics was quantified by the largest Lyapunov exponent and the stride time fluctuations were quantified by sample entropy and detrended fluctuation analysis. The motor control was assessed by the soleus (SO) Hoffmann (H)-reflex modulation and muscle co-activation during walking. The results showed no statistically significant mean group differences in any of the gait variability measures or muscle co-activation levels. The SO H-reflex amplitude was significantly higher in the knee OA group around heel strike when compared with the controls. The mean group difference in the H-reflex in the initial part of the stance phase (control-knee OA) was -6.6% Mmax (95% CI: -10.4 to -2.7, p=0.041). The present OA group reported relatively small impact of their disease. These results suggest that the OA group in general sustained a normal gait pattern with natural variability but with suggestions of facilitated SO H-reflex in the swing to stance phase transition. We speculate that the difference in SO H-reflex modulation reflects that the OA group increased the excitability of the soleus stretch reflex as a preparatory mechanism to avoid sudden collapse of the knee joint which is not uncommon in knee OA. Copyright © 2015 Elsevier B.V. All rights reserved.

Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis.

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Verbeeck, Nico; Spraggins, Jeffrey M; Murphy, Monika J M; Wang, Hui-Dong; Deutch, Ariel Y; Caprioli, Richard M; Van de Plas, Raf

2017-07-01

Imaging mass spectrometry (IMS) is a molecular imaging technology that can measure thousands of biomolecules concurrently without prior tagging, making it particularly suitable for exploratory research. However, the data size and dimensionality often makes thorough extraction of relevant information impractical. To help guide and accelerate IMS data analysis, we recently developed a framework that integrates IMS measurements with anatomical atlases, opening up opportunities for anatomy-driven exploration of IMS data. One example is the automated anatomical interpretation of ion images, where empirically measured ion distributions are automatically decomposed into their underlying anatomical structures. While offering significant potential, IMS-atlas integration has thus far been restricted to the Allen Mouse Brain Atlas (AMBA) and mouse brain samples. Here, we expand the applicability of this framework by extending towards new animal species and a new set of anatomical atlases retrieved from the Scalable Brain Atlas (SBA). Furthermore, as many SBA atlases are based on magnetic resonance imaging (MRI) data, a new registration pipeline was developed that enables direct non-rigid IMS-to-MRI registration. These developments are demonstrated on protein-focused FTICR IMS measurements from coronal brain sections of a Parkinson's disease (PD) rat model. The measurements are integrated with an MRI-based rat brain atlas from the SBA. The new rat-focused IMS-atlas integration is used to perform automated anatomical interpretation and to find differential ions between healthy and diseased tissue. IMS-atlas integration can serve as an important accelerator in IMS data exploration, and with these new developments it can now be applied to a wider variety of animal species and modalities. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2017. Published by Elsevier B.V.

Noninvasive Multimodality Imaging of the Tumor Microenvironment: Registered Dynamic Magnetic Resonance Imaging and Positron Emission Tomography Studies of a Preclinical Tumor Model of Tumor Hypoxia

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HyungJoon Cho

2009-03-01

Full Text Available In vivo knowledge of the spatial distribution of viable, necrotic, and hypoxic areas can provide prognostic information about the risk of developing metastases and regional radiation sensitivity and may be used potentially for localized dose escalation in radiation treatment. In this study, multimodality in vivo magnetic resonance imaging (MRI and positron emission tomography (PET imaging using stereotactic fiduciary markers in the Dunning R3327AT prostate tumor were performed, focusing on the relationship between dynamic contrast-enhanced (DCE MRI using Magnevist (Gd-DTPA and dynamic 18F-fluoromisonidazole (18F-Fmiso PET. The noninvasive measurements were verified using tumor tissue sections stained for hematoxylin/eosin and pimonidazole. To further validate the relationship between 18F-Fmiso and pimonidazole uptake, 18F digital autoradiography was performed on a selected tumor and compared with the corresponding pimonidazole-stained slices. The comparison of Akep values (kep = rate constant of movement of Gd-DTPA between the interstitial space and plasma and A = amplitude in the two-compartment model (Hoffmann U, Brix G, Knopp MV, Hess T and Lorenz WJ (1995. Magn Reson Med 33, 506– 514 derived from DCE-MRI studies and from early 18F-Fmiso uptake PET studies showed that tumor vasculature is a major determinant of early 18F-Fmiso uptake. A negative correlation between the spatial map of Akep and the slope map of late (last 1 hour of the dynamic PET scan 18F-Fmiso uptake was observed. The relationships between DCE-MRI and hematoxylin/eosin slices and between 18F-Fmiso PET and pimonidazole slices confirm the validity of MRI/PET measurements to image the tumor microenvironment and to identify regions of tumor necrosis, hypoxia, and well-perfused tissue.

Four-spacecraft determination of magnetopause orientation, motion and thickness: comparison with results from single-spacecraft methods

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S. E. Haaland

2004-04-01

Full Text Available In this paper, we use Cluster data from one magnetopause event on 5 July 2001 to compare predictions from various methods for determination of the velocity, orientation, and thickness of the magnetopause current layer. We employ established as well as new multi-spacecraft techniques, in which time differences between the crossings by the four spacecraft, along with the duration of each crossing, are used to calculate magnetopause speed, normal vector, and width. The timing is based on data from either the Cluster Magnetic Field Experiment (FGM or the Electric Field Experiment (EFW instruments. The multi-spacecraft results are compared with those derived from various single-spacecraft techniques, including minimum-variance analysis of the magnetic field and deHoffmann-Teller, as well as Minimum-Faraday-Residue analysis of plasma velocities and magnetic fields measured during the crossings. In order to improve the overall consistency between multi- and single-spacecraft results, we have also explored the use of hybrid techniques, in which timing information from the four spacecraft is combined with certain limited results from single-spacecraft methods, the remaining results being left for consistency checks. The results show good agreement between magnetopause orientations derived from appropriately chosen single-spacecraft techniques and those obtained from multi-spacecraft timing. The agreement between magnetopause speeds derived from single- and multi-spacecraft methods is quantitatively somewhat less good but it is evident that the speed can change substantially from one crossing to the next within an event. The magnetopause thickness varied substantially from one crossing to the next, within an event. It ranged from 5 to 10 ion gyroradii. The density profile was sharper than the magnetic profile: most of the density change occured in the earthward half of the magnetopause.

Key words. Magnetospheric physics (magnetopause, cusp and

Influence of the equation of state of matter and ion beam characteristics on target heating and compression

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N. A. Tahir

2003-02-01

Full Text Available The subject of high-energy density (HED in matter is of considerable interest to many branches of physics. Intense beams of energetic heavy ions are a promising tool for creating large samples of HED matter which can be used to study the equation-of-state properties of such exotic states of matter experimentally. The Gesellschaft für Schwerionenforschung (GSI, Darmstadt, is a unique laboratory worldwide which has a heavy ion synchrotron facility, SIS18 (with a magnetic rigidity of 18 Tm, that delivers intense heavy ion beams. Using the beams generated at this present facility, interesting experimental work has been carried out in the field of HED matter [D. H. H. Hoffmann et al., Nucl. Instrum. Methods Phys. Res., Sect. B 161–162, 9 (2000]. The GSI is planning to significantly expand its accelerator capabilities with construction of a new synchrotron ring, SIS100, which will have a magnetic rigidity of 100 Tm. This new facility will deliver a uranium beam which will have orders of magnitude higher intensity than the existing facility and will also have the possibility of multibeam acceleration. This paper presents two-dimensional hydrodynamic simulations of different target geometries including solid as well as hollow cylinders that are irradiated with beams having different shapes of the focal spot which will be available at the SIS100 facility. These include a circular focal spot, an annular focal spot, and an elliptic focal spot, respectively. The purpose of this study is to determine the region of the physical parameters including density, temperature, and pressure that can be accessed using the SIS100 beam. This information, we hope, will be useful for designing experiments on the studies of thermophysical properties of matter including the designing of appropriate diagnostic tools.

Estudio clínico, genético y molecular en un paciente con atrofia muscular espinal

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Ibis Menéndez Alejo

1998-03-01

Full Text Available Las atrofias musculares espinales (AME infantiles son enfermedades neuromusculares hereditarias caracterizadas por la degeneración de las motoneuronas alfa del asta anterior de la médula espinal. La enfermedad de Werdnig-Hoffmann, AME tipo I, es la forma más grave, se transmite como un carácter autosómico recesivo y los afectados suelen fallecer durante el primer año de vida por fallo respiratorio. En este trabajo se presenta una familia cubana con 2 hijos con AME tipo I, en la cual el estudio molecular en uno de ellos permitió identificar los 2 cromosomas parentales asociados con ésta. Se encontró además en el paciente una deleción de ambas copias del gen SMN (exón 8 y del gen NAIP (exón 5. Los hallazgos ilustran la utilidad de estos estudios, con vistas a posibilitar el diagnóstico prenatal de la enfermedad.The infantile spinal muscular atrophies (SMA are hereditary neuromuscular diseases characterized by degenerated Alfa-motoneurons of the anterior spinal marrow horn. Werdning-Hoffman disease, Type 1 SMA, is the most serious affection being transmitted as an autosomal recessive character, so those affected may die from respiratory failures in the first year of life. This paper presents a Cuban family with two kids who suffer from Type-1 SMA; the molecular analysis carried out in one of them identified two parental chromosomes responsible for the disease. Also, a deletion of both copies of SMN gene (exon 8 and NAIP gene (exon 5 were discovered in this patient. These findings showed the usefulness of this kind of studies with a view to making a prenatal diagnosis of Werdning-Hoffman disease.

Role of spared pathways in locomotor recovery after body-weight-supported treadmill training in contused rats.

Science.gov (United States)

Singh, Anita; Balasubramanian, Sriram; Murray, Marion; Lemay, Michel; Houle, John

2011-12-01

Body-weight-supported treadmill training (BWSTT)-related locomotor recovery has been shown in spinalized animals. Only a few animal studies have demonstrated locomotor recovery after BWSTT in an incomplete spinal cord injury (SCI) model, such as contusion injury. The contribution of spared descending pathways after BWSTT to behavioral recovery is unclear. Our goal was to evaluate locomotor recovery in contused rats after BWSTT, and to study the role of spared pathways in spinal plasticity after BWSTT. Forty-eight rats received a contusion, a transection, or a contusion followed at 9 weeks by a second transection injury. Half of the animals in the three injury groups were given BWSTT for up to 8 weeks. Kinematics and the Basso-Beattie-Bresnahan (BBB) test assessed behavioral improvements. Changes in Hoffmann-reflex (H-reflex) rate depression property, soleus muscle mass, and sprouting of primary afferent fibers were also evaluated. BWSTT-contused animals showed accelerated locomotor recovery, improved H-reflex properties, reduced muscle atrophy, and decreased sprouting of small caliber afferent fibers. BBB scores were not improved by BWSTT. Untrained contused rats that received a transection exhibited a decrease in kinematic parameters immediately after the transection; in contrast, trained contused rats did not show an immediate decrease in kinematic parameters after transection. This suggests that BWSTT with spared descending pathways leads to neuroplasticity at the lumbar spinal level that is capable of maintaining locomotor activity. Discontinuing training after the transection in the trained contused rats abolished the improved kinematics within 2 weeks and led to a reversal of the improved H-reflex response, increased muscle atrophy, and an increase in primary afferent fiber sprouting. Thus continued training may be required for maintenance of the recovery. Transected animals had no effect of BWSTT, indicating that in the absence of spared pathways this

Equations of motion according to the asymptotic post-Newtonian scheme for general relativity in the harmonic gauge

Science.gov (United States)

Arminjon, Mayeul

2005-10-01

The asymptotic scheme of post-Newtonian approximation defined for general relativity in the harmonic gauge by Futamase & Schutz (1983) is based on a family of initial data for the matter fields of a perfect fluid and for the initial metric, defining a family of weakly self-gravitating systems. We show that Weinberg’s (1972) expansion of the metric and his general expansion of the energy-momentum tensor T, as well as his expanded equations for the gravitational field and his general form of the expanded dynamical equations, apply naturally to this family. Then, following the asymptotic scheme, we derive the explicit form of the expansion of T for a perfect fluid, and the expanded fluid-dynamical equations. (These differ from those written by Weinberg.) By integrating these equations in the domain occupied by a body, we obtain a general form of the translational equations of motion for a 1PN perfect-fluid system in general relativity. To put them into a tractable form, we use an asymptotic framework for the separation parameter η, by defining a family of well-separated 1PN systems. We calculate all terms in the equations of motion up to the order η3 included. To calculate the 1PN correction part, we assume that the Newtonian motion of each body is a rigid one, and that the family is quasispherical, in the sense that in all bodies the inertia tensor comes close to being spherical as η→0. Apart from corrections that cancel for exact spherical symmetry, there is in the final equations of motion one additional term, as compared with the Lorentz-Droste (Einstein-Infeld-Hoffmann) acceleration. This term depends on the spin of the body and on its internal structure.

Hemifield columns co-opt ocular dominance column structure in human achiasma.

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Olman, Cheryl A; Bao, Pinglei; Engel, Stephen A; Grant, Andrea N; Purington, Chris; Qiu, Cheng; Schallmo, Michael-Paul; Tjan, Bosco S

2018-01-01

In the absence of an optic chiasm, visual input to the right eye is represented in primary visual cortex (V1) in the right hemisphere, while visual input to the left eye activates V1 in the left hemisphere. Retinotopic mapping In V1 reveals that in each hemisphere left and right visual hemifield representations are overlaid (Hoffmann et al., 2012). To explain how overlapping hemifield representations in V1 do not impair vision, we tested the hypothesis that visual projections from nasal and temporal retina create interdigitated left and right visual hemifield representations in V1, similar to the ocular dominance columns observed in neurotypical subjects (Victor et al., 2000). We used high-resolution fMRI at 7T to measure the spatial distribution of responses to left- and right-hemifield stimulation in one achiasmic subject. T 2 -weighted 2D Spin Echo images were acquired at 0.8mm isotropic resolution. The left eye was occluded. To the right eye, a presentation of flickering checkerboards alternated between the left and right visual fields in a blocked stimulus design. The participant performed a demanding orientation-discrimination task at fixation. A general linear model was used to estimate the preference of voxels in V1 to left- and right-hemifield stimulation. The spatial distribution of voxels with significant preference for each hemifield showed interdigitated clusters which densely packed V1 in the right hemisphere. The spatial distribution of hemifield-preference voxels in the achiasmic subject was stable between two days of testing and comparable in scale to that of human ocular dominance columns. These results are the first in vivo evidence showing that visual hemifield representations interdigitate in achiasmic V1 following a similar developmental course to that of ocular dominance columns in V1 with intact optic chiasm. Copyright © 2017 Elsevier Inc. All rights reserved.

High resolution reconstruction of PET images using the iterative OSEM algorithm

International Nuclear Information System (INIS)

Doll, J.; Bublitz, O.; Werling, A.; Haberkorn, U.; Semmler, W.; Adam, L.E.; Pennsylvania Univ., Philadelphia, PA; Brix, G.

2004-01-01

Aim: Improvement of the spatial resolution in positron emission tomography (PET) by incorporation of the image-forming characteristics of the scanner into the process of iterative image reconstruction. Methods: All measurements were performed at the whole-body PET system ECAT EXACT HR + in 3D mode. The acquired 3D sinograms were sorted into 2D sinograms by means of the Fourier rebinning (FORE) algorithm, which allows the usage of 2D algorithms for image reconstruction. The scanner characteristics were described by a spatially variant line-spread function (LSF), which was determined from activated copper-64 line sources. This information was used to model the physical degradation processes in PET measurements during the course of 2D image reconstruction with the iterative OSEM algorithm. To assess the performance of the high-resolution OSEM algorithm, phantom measurements performed at a cylinder phantom, the hotspot Jaszczack phantom, and the 3D Hoffmann brain phantom as well as different patient examinations were analyzed. Results: Scanner characteristics could be described by a Gaussian-shaped LSF with a full-width at half-maximum increasing from 4.8 mm at the center to 5.5 mm at a radial distance of 10.5 cm. Incorporation of the LSF into the iteration formula resulted in a markedly improved resolution of 3.0 and 3.5 mm, respectively. The evaluation of phantom and patient studies showed that the high-resolution OSEM algorithm not only lead to a better contrast resolution in the reconstructed activity distributions but also to an improved accuracy in the quantification of activity concentrations in small structures without leading to an amplification of image noise or even the occurrence of image artifacts. Conclusion: The spatial and contrast resolution of PET scans can markedly be improved by the presented image restauration algorithm, which is of special interest for the examination of both patients with brain disorders and small animals. (orig.)

Using OWL reasoning to support the generation of novel gene sets for enrichment analysis.

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Osumi-Sutherland, David J; Ponta, Enrico; Courtot, Melanie; Parkinson, Helen; Badi, Laura

2018-02-14

The Gene Ontology (GO) consists of over 40,000 terms for biological processes, cell components and gene product activities linked into a graph structure by over 90,000 relationships. It has been used to annotate the functions and cellular locations of several million gene products. The graph structure is used by a variety of tools to group annotated genes into sets whose products share function or location. These gene sets are widely used to interpret the results of genomics experiments by assessing which sets are significantly over- or under-represented in results lists. F Hoffmann-La Roche Ltd. has developed a bespoke, manually maintained controlled vocabulary (RCV) for use in over-representation analysis. Many terms in this vocabulary group GO terms in novel ways that cannot easily be derived using the graph structure of the GO. For example, some RCV terms group GO terms by the cell, chemical or tissue type they refer to. Recent improvements in the content and formal structure of the GO make it possible to use logical queries in Web Ontology Language (OWL) to automatically map these cross-cutting classifications to sets of GO terms. We used this approach to automate mapping between RCV and GO, largely replacing the increasingly unsustainable manual mapping process. We then tested the utility of the resulting groupings for over-representation analysis. We successfully mapped 85% of RCV terms to logical OWL definitions and showed that these could be used to recapitulate and extend manual mappings between RCV terms and the sets of GO terms subsumed by them. We also show that gene sets derived from the resulting GO terms sets can be used to detect the signatures of cell and tissue types in whole genome expression data. The rich formal structure of the GO makes it possible to use reasoning to dynamically generate novel, biologically relevant groupings of GO terms. GO term groupings generated with this approach can be used in. over-representation analysis to detect

Cross-year peer tutoring on internal medicine wards: results of a qualitative focus group analysis

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Krautter M

2014-09-01

Full Text Available Markus Krautter,1 Sven Andreesen,2 Nadja Köhl-Hackert,2 Katja Hoffmann,3 Wolfgang Herzog,2 Christoph Nikendei2 1Department of Nephrology, University of Heidelberg, 2Department of General Internal Medicine and Psychosomatics, University of Heidelberg Medical Hospital, 3Department of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany Background: Peer-assisted learning (PAL has become a well-accepted teaching method within medical education. However, descriptions of on-ward PAL programs are rare. A focus group analysis of a newly established PAL program on an internal medicine ward was conducted to provide insights into PAL teaching from a student perspective.Purpose: To provide insights into students' experiences regarding their on-ward training with and without accompanying PAL tutors.Methods: A total of N=168 medical students in their sixth semester participated in the investigation (intervention group: N=88; control group: N=80. The intervention group took part in the PAL program, while the control group received standard on-ward training. There were seven focus groups with N=43 participants (intervention group: four focus groups, N=28 participants; control group: three focus groups, N=15 participants. The discussions were analyzed using content analysis.Results: The intervention group emphasized the role of the tutors as competent and well-trained teachers, most beneficial in supervising clinical skills. Tutors motivate students, help them to integrate into the ward team, and provide a non-fear-based working relationship whereby students' anxiety regarding working on ward decreases. The control group had to rely on autodidactic learning strategies when neither supervising physicians nor final-year students were available.Conclusion: On-ward PAL programs represent a particularly valuable tool for students' support in training clinical competencies on ward. The tutor–student working alliance

A step forward in molecular diagnostics of lyssaviruses--results of a ring trial among European laboratories.

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Melina Fischer

Full Text Available Rabies is a lethal and notifiable zoonotic disease for which diagnostics have to meet the highest standards. In recent years, an evolution was especially seen in molecular diagnostics with a wide variety of different detection methods published. Therefore, a first international ring trial specifically designed on the use of reverse transcription polymerase chain reaction (RT-PCR for detection of lyssavirus genomic RNA was organized. The trial focussed on assessment and comparison of the performance of conventional and real-time assays. In total, 16 European laboratories participated. All participants were asked to investigate a panel of defined lyssavirus RNAs, consisting of Rabies virus (RABV and European bat lyssavirus 1 and 2 (EBLV-1 and -2 RNA samples, with systems available in their laboratory. The ring trial allowed the important conclusion that conventional RT-PCR assays were really robust assays tested with a high concordance between different laboratories and assays. The real-time RT-PCR system by Wakeley et al. (2005 in combination with an intercalating dye, and the combined version by Hoffmann and co-workers (2010 showed good sensitivity for the detection of all RABV samples included in this test panel. Furthermore, all used EBLV-specific assays, real-time RT-PCRs as well as conventional RT-PCR systems, were shown to be suitable for a reliable detection of EBLVs. It has to be mentioned that differences were seen in the performance between both the individual RT-PCR systems and the laboratories. Laboratories which used more than one molecular assay for testing the sample panel always concluded a correct sample result. Due to the markedly high genetic diversity of lyssaviruses, the application of different assays in diagnostics is needed to achieve a maximum of diagnostic accuracy. To improve the knowledge about the diagnostic performance proficiency testing at an international level is recommended before using lyssavirus molecular

On the mesoscopic origins of high viscosities in some polyelectrolyte-surfactant mixtures

Energy Technology Data Exchange (ETDEWEB)

Hoffmann, Ingo, E-mail: ingo.hoffmann@tu-berlin.de [Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, Sekr. TC 7, D-10623 Berlin (Germany); Institut Max von Laue-Paul Langevin (ILL), F-38042 Grenoble Cedex 9 (France); Farago, Bela; Schweins, Ralf; Falus, Peter; Sharp, Melissa [Institut Max von Laue-Paul Langevin (ILL), F-38042 Grenoble Cedex 9 (France); Prévost, Sylvain [Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, Sekr. TC 7, D-10623 Berlin (Germany); Helmholtz-Zentrum Berlin, D-14109 Berlin (Germany); Gradzielski, Michael, E-mail: michael.gradzielski@tu-berlin.de [Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, Sekr. TC 7, D-10623 Berlin (Germany)

2015-08-21

Oppositely charged polyelectrolyte (PE) surfactant mixtures allow the control of rheological parameters of a solution even at fairly low concentrations. For example, addition of 0.3 wt. % of anionic surfactant to a 1 wt. % solution of the polycation JR 400 increases the viscosity by 4 orders of magnitude. Recently, we could show that this increase is related to the formation of mixed, rod-like PE/surfactant aggregates which interconnect several polyelectrolyte chains [Hoffmann et al., Europhys. Lett. 104, 28001 (2013)]. In this paper, we refine our structural model of the aggregates to obtain a more consistent picture of their internal structure for different anionic surfactants. Combining small angle neutron scattering (SANS) and neutron spin-echo (NSE) allows us to determine the size of the aggregates. By comparing different contrasts, the internal structure of the aggregates can be elucidated and it is seen that the PE in the aggregates retains a relatively high freedom of movement. We proceeded to investigate the influence of the surfactant concentration and the surfactant type on structure and dynamics of the mixed aggregates. It is seen that the structural parameters of the aggregates depend very little on the surfactant concentration and headgroup. However, it is crucial to incorporate a sufficient amount of PE in the aggregates to increase the viscosity of the aggregates. By comparing viscous samples at 1 wt. % PE concentration with samples at a PE concentration of 0.3 wt. %, where no significant increase in viscosity is observed, we find that similar aggregates are formed already at this lower PE concentrations. However, the amount of PE incorporated in them is insufficient to interconnect several PE chains and therefore, they do not increase viscosity. So, our detailed investigation combining contrast variation SANS and NSE does not only allow to explain the viscosity behavior but also to deduced detailed information regarding the structures and

PREFACE: Interfacial Nanostructures in Ceramics: a Multiscale Approach

Science.gov (United States)

Finnis, Mike; Gautier-Soyer, Martine; Hoffmann, Michael

2008-04-01

This volume contains a selection of invited and contributed papers that were presented in Symposium J at the European Materials Research Society Spring Meeting, 28 May-1 June 2007. Electronic and mechanical properties of interfaces are sensitive to their atomic scale structures, which in turn depend on composition, temperature and indeed the history of environments of the material during its manufacture. The richness of structure and numbers of parameters involved, even for planar interfaces, present enormous challenges to the community of theory and simulation of materials, at all lengthscales from the atomic to the macroscopic. While there is a need for modelling and simulation in order to understand, predict and then design materials, this can only be achieved when researchers at each length scale learn about the strengths and limitations of each others' approaches, and how they can validate their models by exchange of information and analysis of experimental data. To this end the Symposium brought such researchers from the theoretical community together with experimentalists. A volume like this gives a snapshot of progress made, but does not fully capture the value of the Symposium in setting new ideas in motion, or helping to bury old ones. We are grateful to all participants for the lively discussions, to E-MRS for enabling the meeting, and to the European Community INCEMS Project, which has provided funding for this research activity. This volume is dedicated to Rowland Cannon, who was deeply involved in the conception and elaboration of the ideas about Interfacial Nanostructures that are at the heart of the INCEMS project, and whose unexpected death two years ago was a great loss to our community. Finally we acknowledge the support of IOP Publishing for enabling these papers to be made freely available to download from the electronic version of Journal of Physics: Conference Series. Mike Finnis, Martine Gautier-Soyer and Michael Hoffmann Editors

Assessment of health aspects in some X-ray examination types from gonad dose measurements on phantoms with or without shielding

International Nuclear Information System (INIS)

Dermendzhiev, Kh.; Velikov, V.; Katerinov, E.

1975-01-01

X-ray mass screening examinations have been found to lead, particularly in countries with a welldeveloped medical service, to substantial population exposure, namely in the range of 20 to 150 mrad per year versus 100 mrad per year from natural radiation background. A substantial share of this exposure stems from gonad doses delivered to patients in the course of various types of diagnostic X-ray procedures. The magnitude of doses absorbed by the gonads depends to a large extent on shielding devices used to protect the patient during the examination, on the nature of the examination - whether gonads lie directly under the beam - and a number of other factors. For the present study, four phantoms corresponding to a selection of ages (2, 7, 14, and 25 years of age) were prepared. Dosimetric measurements were performed on a ''Hoffmann SR 700 D'' X-ray apparatus, with simulation of various types of diagnostic procedures: roentgenoscopic examinations or films, with or without shielding, with or without use of image converters. The data obtained indicated that the X-ray procedure types investigated may be grouped, in descending order or associated radiation exposures, as follows: roentgenoscopy of GI tract in children or women, roentgenography of lumbar vertebrae, pelvic organs, kidneys, thighs. There are cases where shielding is unfeasible (roentgenoscopy of GI tract in children or women, pelvic organ and kidney examination in women). In other cases, gonad shielding is of low efficiency: roentgenoscopy of lumbar vertebrae, skull or chest films in men. With use of image converters, a gonad-dose reduction by a factor of 2 to 9 is achieved. In terms of gonad dose level to the patient, X-ray procedure types may be distributed into three main groups: (1) low level (skull or chest films, etc.); (2) intermediate level (lung roentgenoscopy, thigh film, etc.); (3) high level, with gonads lying in the primary-beam field (GI tract roentgenoscopy, pelvic film, etc.). (author)

Essential oils as biological alternatives to protect date palm (Phoenix dactylifera L. against Ectomyelois ceratoniae Zeller (Lepidoptera: Pyralidae

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Ismail Amri

2014-09-01

Full Text Available The aims of this research were to determine the chemical composition of the essential oil of three Tunisian plants and to evaluate their biological activity against eggs, larvae, and adult insects of Ectomyelois ceratoniae Zeller. The essential oils extracted from leaves of Thymus capitatus (L. Hoffmanns. & Link, Rosmarinus officinalis L. and needles of Pinus halepensis Mill. were analyzed by gas chromatography-mass spectrometry; 34, 16, and 56 constituents were identified, respectively. The major constituents were (Z-caryophyllene (23.8%, β-myrcene (20.5% and α-pinene (13.3% in P. halepensis oil, carvacrol (66.9%, p-cymene (9.1%, and δ-terpinene (6.2% in T. capitatus oil and 1,8-cineole (47.5%, camphor (14.9%, α-pinene (14.1%, and borneol (13.1% in R. officinalis oil. The insecticidal effects of essential oils on eggs, larvae, and adults of E. ceratoniae were investigated. Ovicidal activity of oils was studied by spray on eggs while larvicidal and adulticidal activities were assessed by fumigation and spray. Number of hatched eggs was verified after 10 d, larva and adult mortalities were observed after 6, 12, and 24 h. Globally, eggs and larvae were the most resistant to the three different oils, needing higher doses to obtain a higher mortality. The spray method was most effective than fumigation. Essential oil extracted from T. capitatus proved to be very toxic towards E. ceratoniae on all three phases at the dose of 20 μL mL-1 (100% inhibition, followed by the oil from R. officinalis (90-100% inhibition, nevertheless, weak activity was obtained with P. halepensis oil (68.3-85% inhibition. Results obtained may suggest that the essential oils of T. capitatus and R. officinalis possess high insecticidal activity and therefore, can be used in biotechnological application as natural preservative in stored dates and could be useful in managing populations of E. ceratoniae in field.

FISHing Out the Hidden Enemy: Advances in Detecting and Measuring Latent HIV-Infected Cells.

Science.gov (United States)

Prasad, Vinayaka R; Kalpana, Ganjam V

2017-09-19

The indomitable aspect of HIV-1 infection is not that HIV-1 proviral DNA is integrated into host DNA but that it can also turn itself off, remaining invisible to drug or immune surveillance. Thus, the goals of eradication include ways to precisely excise HIV-1 DNA or wake up the silent HIV-1 provirus and eliminate the infected cells thus identified. Methods to identify and fish out the latently infected cells or to delineate their characteristics are being rapidly developed. In 2016, Baxter et al. (A. E. Baxter, J. Niessl, R. Fromentin, J. Richard, F. Porichis, R. Charlebois, M. Massanella, N. Brassard, N. Alsahafi, G. G. Delgado, J. P. Routy, B. D. Walker, A. Finzi, N. Chomont, and D. E. Kaufmann, Cell Host Microbe 20:368-380, 2016, https://doi.org/10.1016/j.chom.2016.07.015) and Martrus et al. (G. Martrus, A. Niehrs, R. Cornelis, A. Rechtien, W. García-Beltran, M. Lütgehetmann, C. Hoffmann, and M. Altfeld, J Virol 90:9018-9028, 2016, https://doi.org/10.1128/JVI.01448-16) reported using the fluorescence in situ hybridization-flow cytometry technique to identify and quantify cells expressing HIV-1 RNA and Gag protein, as well as bearing unique cell surface markers. In a recent article in mBio , Grau-Expósito et al. (J. Grau-Expósito, C. Serra-Peinado, L. Miguel, J. Navarro, A. Curran, J. Burgos, I. Ocaña, E. Ribera, A. Torrella, B. Planas, R. Badía, J. Castellví, V. Falcó, M. Crespo, and M. J. Buzon, mBio 8:e00876-17, 2017, https://doi.org/10.1128/mBio.00876-17) reported a similar method that they claim to be more sensitive. With these methods, researchers are one step closer to measuring latent reservoirs and eliminating critical barriers to HIV eradication. Copyright © 2017 Prasad and Kalpana.

2. Sino-German workshop on fuel cells. Book of abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

The CD-ROM contains the content of 13 lectures and 19 proposals for joint projects, which were presented on the second Sino-German Workshop on fuel cells. The topics of the 13 lectures are: Ab-initio calculations of oxygen species on low-index platinum surfaces (Pachenko, M.T.M. Koper, T.E. Shubina, S.J. Mitchell, E. Roduner). Cross-Linked (Composite) Polyaryl Blend Membranes for Membrane Fuel Cells. (J.A. Kerres, A. Ullrich, W. Zhang, M. Hein, V. Gogel, L. Joerissen, Th. Frey, A. Friedrich). Performance and Methanol Permeation of Direct Methanol Fuel Cells: Dependence on Operating Conditions and on Electrode Structure(V. Gogel, Th. Frey, K.A. Friedrich, L. Joerissen, J. Garche, Z. Yongsheng). Experimental Investigation of Flow Bed Configuration Effect on Performance of Liquid Feed Direct Methanol Fuel Cells. (H. Guo, C.F. Ma, M.H. Wang, F. Ye, J. Yu, Y. Wang, C.Y. Wang). Improvement of MEAs for DMFC by a tuned production sequence assisted by mathematical modelling (Lindermeir, G. Rosenthal, U. Kunz, U. Hoffmann). Performance of the self-breathing air DMFC with solution grafted PVDF-g-PSSA membranes (X. Qiu, G. Guo, W. Li, W. Zhu, L. Chen). Modeling the Effects of Methanol Crossover on DMFC (J. Zhang, Y. Wang). The characteristics of 40 kW PEM fuel cell engine for vehicle(M. Hou, P. Ming, H. Zhang). A New and Simple Method for Preparing Biocathode in Biofuel Cells (D. Sun, C. Cai, X. Li, W. Xing, T. Lu). Nonlinear Model Reduction of a Dynamic Two-dimensional Molten Carbonate Fuel Cell Model (M. Mangold, M. Sheng). Recent Advances in Design and Fabrication of Low-Temperature Solid Oxide Fuel Cells (C. Xia, G. Meng). Novel CVD Techniques for Micro- and IT-SOFC Fabrication (G. Meng, H. Song, Q. Dong, D. Peng). Fundamental properties of La{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3-{delta}} at high temperatures (S. Wang, T.-L. Wen).

Validation of a treatment satisfaction questionnaire in non-Hodgkin lymphoma: assessing the change from intravenous to subcutaneous administration of rituximab

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Theodore-Oklota C

2016-09-01

Full Text Available Christina Theodore-Oklota,1 Louise Humphrey,2 Christof Wiesner,1 Gabriel Schnetzler,3 Stacie Hudgens,4 Alicyn Campbell1 1Genentech, South San Francisco, CA, USA; 2Adelphi Values, Macclesfield, Cheshire, UK; 3F. Hoffmann La-Roche Ltd, Basel, Switzerland; 4Clinical Outcomes Solutions, Tucson, AZ, USA Background: A subcutaneous (SC formulation of rituximab (MabThera®/Rituxan® has been developed that could reduce administration time and improve patient satisfaction with treatment. The Rituximab Administration Satisfaction Questionnaire (RASQ was created to assess patients’ perceptions and satisfaction with rituximab SC (RASQ-SC or rituximab intravenous (RASQ-IV. We assessed the content validity and psychometric properties of RASQ in patients with non-Hodgkin lymphoma.Methods: Face and content validity of RASQ-SC and RASQ-IV were qualitatively assessed using 60-minute combined concept elicitation and cognitive debriefing interviews. Psychometric validation of RASQ (item performance and reliability was assessed quantitatively against the established Cancer Therapy Satisfaction Questionnaire (CTSQ, using questionnaire data from the PrefMab (NCT01724021 and MabCute (NCT01461928 clinical studies.Results: RASQ-IV demonstrated excellent coverage of concepts relevant to patients’ (n=10 own treatment experiences and no new concepts were identified. Patients’ expectations of rituximab SC were conceptually consistent with items included in the RASQ-SC, suggesting that the tool is also conceptually adequate. In 1,051 patients from PrefMab and MabCute, correlations with domains such as “RASQ: Physical Impacts” and “CTSQ: Feelings About Side Effects”, “RASQ: Physical Impacts” and “CTSQ: Satisfaction With Therapy”, and “RASQ: Satisfaction” and “CTSQ: Satisfaction With Therapy”, achieved moderate-to-high correlations (>0.4 for convergent domains and <0.3 for divergent domains.Conclusion: This study supports the qualitative face and

Electrical Stimulation of Low-Threshold Proprioceptive Fibers in the Adult Rat Increases Density of Glutamatergic and Cholinergic Terminals on Ankle Extensor α-Motoneurons.

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Olga Gajewska-Woźniak

Full Text Available The effects of stimulation of low-threshold proprioceptive afferents in the tibial nerve on two types of excitatory inputs to α-motoneurons were tested. The first input is formed by glutamatergic Ia sensory afferents contacting monosynaptically α-motoneurons. The second one is the cholinergic input originating from V0c-interneurons, located in lamina X of the spinal cord, modulating activity of α-motoneurons via C-terminals. Our aim was to clarify whether enhancement of signaling to ankle extensor α-motoneurons, via direct electrical stimulation addressed predominantly to low-threshold proprioceptive fibers in the tibial nerve of awake rats, will affect Ia glutamatergic and cholinergic innervation of α-motoneurons of lateral gastrocnemius (LG. LG motoneurons were identified with True Blue tracer injected intramuscularly. Tibial nerve was stimulated for 7 days with continuous bursts of three pulses applied in four 20 min sessions daily. The Hoffmann reflex and motor responses recorded from the soleus muscle, LG synergist, allowed controlling stimulation. Ia terminals and C-terminals abutting on LG-labeled α-motoneurons were detected by immunofluorescence (IF using input-specific anti- VGLUT1 and anti-VAChT antibodies, respectively. Quantitative analysis of confocal images revealed that the number of VGLUT1 IF and VAChT IF terminals contacting the soma of LG α-motoneurons increased after stimulation by 35% and by 26%, respectively, comparing to the sham-stimulated side. The aggregate volume of VGLUT1 IF and VAChT IF terminals increased by 35% and by 30%, respectively. Labeling intensity of boutons was also increased, suggesting an increase of signaling to LG α-motoneurons after stimulation. To conclude, one week of continuous burst stimulation of proprioceptive input to LG α-motoneurons is effective in enrichment of their direct glutamatergic but also indirect cholinergic inputs. The effectiveness of such and longer stimulation in models

Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves

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Gompelmann D

2016-12-01

Full Text Available D Gompelmann,1,2 N Benjamin,1 K Kontogianni,1 FJF Herth,1,2 CP Heussel,2–4 H Hoffmann,2,5 R Eberhardt1,2 1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, 3Diagnostic and Interventional Radiology, Thoraxklinik at University of Heidelberg, 4Diagnostic and Interventional Radiology, University Hospital Heidelberg, 5Thoracic Surgery, Thoraxklinik at University of Heidelberg, Heidelberg, Germany Introduction: Valve implantation has evolved as a therapy for patients with advanced emphysema. Although it is a minimally invasive treatment, it is associated with complications, the most common being pneumothorax. Pneumothorax occurs due to the rapid target lobe volume reduction and may be a predictor of clinical benefit despite this complication. Objective: The objective of this study was to conduct an exploratory data analysis of patients who developed a pneumothorax following endoscopic valve therapy for emphysema. Materials and methods: This study performed a retrospective evaluation of pneumothorax management and the impact of pneumothorax on clinical outcomes in 70 patients following valve therapy in 381 consecutive patients. Results: Pneumothorax rate following valve therapy was 18%. Pneumothorax management consisted of chest tube insertion, valve removal, and surgical intervention in 87% (61/70, 44% (31/70, and 19% (13/70 of the patients, respectively. Despite pneumothorax, patients experienced modest but significant improvements in lung function parameters (forced expiratory volume in 1 second: 55±148 mL, residual volume: -390±964 mL, total lung capacity: -348±876; all P<0.05. Persistent lobar atelectasis 3 months after recovering from pneumothorax, which was associated with relevant clinical improvement, was observed in only 21% (15/70 of the patients. Conclusion: Pneumothorax is a frequent severe complication following valve therapy that requires further intervention

Large Hadron Collider at CERN: Beams generating high-energy-density matter.

Science.gov (United States)

Tahir, N A; Schmidt, R; Shutov, A; Lomonosov, I V; Piriz, A R; Hoffmann, D H H; Deutsch, C; Fortov, V E

2009-04-01

This paper presents numerical simulations that have been carried out to study the thermodynamic and hydrodynamic responses of a solid copper cylindrical target that is facially irradiated along the axis by one of the two Large Hadron Collider (LHC) 7 TeV/ c proton beams. The energy deposition by protons in solid copper has been calculated using an established particle interaction and Monte Carlo code, FLUKA, which is capable of simulating all components of the particle cascades in matter, up to multi-TeV energies. These data have been used as input to a sophisticated two-dimensional hydrodynamic computer code BIG2 that has been employed to study this problem. The prime purpose of these investigations was to assess the damage caused to the equipment if the entire LHC beam is lost at a single place. The FLUKA calculations show that the energy of protons will be deposited in solid copper within about 1 m assuming constant material parameters. Nevertheless, our hydrodynamic simulations have shown that the energy deposition region will extend to a length of about 35 m over the beam duration. This is due to the fact that first few tens of bunches deposit sufficient energy that leads to high pressure that generates an outgoing radial shock wave. Shock propagation leads to continuous reduction in the density at the target center that allows the protons delivered in subsequent bunches to penetrate deeper and deeper into the target. This phenomenon has also been seen in case of heavy-ion heated targets [N. A. Tahir, A. Kozyreva, P. Spiller, D. H. H. Hoffmann, and A. Shutov, Phys. Rev. E 63, 036407 (2001)]. This effect needs to be considered in the design of a sacrificial beam stopper. These simulations have also shown that the target is severely damaged and is converted into a huge sample of high-energy density (HED) matter. In fact, the inner part of the target is transformed into a strongly coupled plasma with fairly uniform physical conditions. This work, therefore, has

Cervical Intradural Disc Herniation Causing Progressive Quadriparesis After Spinal Manipulation Therapy: A Case Report and Literature Review.

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Yang, Hwan-Seo; Oh, Young-Min; Eun, Jong-Pil

2016-02-01

Cervical intradural disc herniation (IDH) is an extremely rare condition, comprising only 0.27% of all disc herniations. Three percent of IDHs occur in the cervical, 5% in the thoracic, and over 92% in the lumbar spinal canal. There have been a total of 31 cervical IDHs reported in the literature. The pathogenesis and imaging characteristics of IDH are not fully understood. A preoperative diagnosis is key to facilitating prompt intradural exploration in patients with ambivalent findings, as well as in preventing reoperation. The purpose of reporting our case is to remind clinicians to consider the possibility of cervical IDH during spinal manipulation therapy in patient with chronic neck pain.The patient signed informed consent for publication of this case report and any accompanying image. The ethical approval of this study was waived by the ethics committee of Chonbuk National University Hospital, because this study was case report and the number of patients was manipulation for chronic neck pain over the course of a month. The day prior, he had noticed neck pain and tingling in the bilateral upper and lower extremities during the manipulation procedure. The following day, he presented with bilateral weakness of all 4 extremities, which rendered him unable to walk. Neurological examination demonstrated a positive Hoffmann sign and ankle clonus bilaterally, hypoesthesia below the C5 dermatome, 3/5 strength in the bilateral upper extremities, and 2/5 strength in the lower extremities. This motor weakness was progressive, and he further complained of voiding difficulty.Urgent magnetic resonance imaging (MRI) of the cervical spine revealed large, central disc herniations at C4-C5 and C5-C6 that caused severe spinal cord compression and surrounding edema. We performed C4-C5-C6 anterior cervical discectomy and fusion.The patient's limb weakness improved rapidly within 1 day postoperatively, and he was discharged 4 weeks later. At his 12-month follow-up, the patient had

Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study.

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Crinò, Lucio; Dansin, Eric; Garrido, Pilar; Griesinger, Frank; Laskin, Janessa; Pavlakis, Nick; Stroiakovski, Daniel; Thatcher, Nick; Tsai, Chun-Ming; Wu, Yi-long; Zhou, Caicun

2010-08-01

interrupted after 28 (2%) of 1347 bleeding events and 72 (7%) of 1025 hypertension events, and permanently discontinued after 110 (8%) bleeding events and 40 (4%) hypertension events. No new safety signals were reported. Our results confirm the manageable safety profile of first-line bevacizumab in combination with various standard chemotherapy regimens for treatment of advanced non-squamous NSCLC. F Hoffmann-La Roche Ltd. 2010 Elsevier Ltd. All rights reserved.

Lumbar paravertebral blockade as intractable pain management method in palliative care

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Zaporowska-Stachowiak I

2013-09-01

Full Text Available Iwona Zaporowska-Stachowiak,1,2 Aleksandra Kotlinska-Lemieszek,3 Grzegorz Kowalski,3 Katarzyna Kosicka,4 Karolina Hoffmann,5 Franciszek Główka,4 Jacek Łuczak2 1Department of Pharmacology, 2Palliative Medicine In-patient Unit, University Hospital of Lord’s Transfiguration, 3Department of Palliative Care, 4Department of Physical Pharmacy and Pharmacokinetics, 5Department of Internal Medicine, Metabolic Disorders and Arterial Hypertension, Poznan University of Medical Sciences, Poznan, Poland Abstract: Optimal symptoms control in advanced cancer disease, with refractory to conventional pain treatment, needs an interventional procedure. This paper presents coadministration of local anesthetic (LA via paravertebral blockade (PVB as the alternative to an unsuccessful subcutaneous fentanyl pain control in a 71-year old cancer patient with pathological fracture of femoral neck, bone metastases, and contraindications to morphine. Bupivacaine in continuous infusion (0.25%, 5 mL · hour-1 or in boluses (10 mL of 0.125%–0.5% solution, used for lumbar PVB, resulted in pain relief, decreased demand for opioids, and led to better social interactions. The factors contributing to an increased risk of systemic toxicity from LA in the patient were: renal impairment; heart failure; hypoalbuminemia; hypocalcemia; and a complex therapy with possible drug–drug interactions. These factors were taken into consideration during treatment. Bupivacaine’s side effects were absent. Coadministered drugs could mask LA’s toxicity. Elevated plasma α1-acid glycoprotein levels were a protective factor. To evaluate the benefit-risk ratio of the PVB treatment in boluses and in constant infusion, bupivacaine serum levels were determined and the drug plasma half-lives were calculated. Bupivacaine’s elimination was slower when administered in constant infusion than in boluses (t½ = 7.80 hours versus 2.64 hours. Total drug serum concentrations remained within the safe

FISHing Out the Hidden Enemy: Advances in Detecting and Measuring Latent HIV-Infected Cells

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Vinayaka R. Prasad

2017-09-01

Full Text Available The indomitable aspect of HIV-1 infection is not that HIV-1 proviral DNA is integrated into host DNA but that it can also turn itself off, remaining invisible to drug or immune surveillance. Thus, the goals of eradication include ways to precisely excise HIV-1 DNA or wake up the silent HIV-1 provirus and eliminate the infected cells thus identified. Methods to identify and fish out the latently infected cells or to delineate their characteristics are being rapidly developed. In 2016, Baxter et al. (A. E. Baxter, J. Niessl, R. Fromentin, J. Richard, F. Porichis, R. Charlebois, M. Massanella, N. Brassard, N. Alsahafi, G. G. Delgado, J. P. Routy, B. D. Walker, A. Finzi, N. Chomont, and D. E. Kaufmann, Cell Host Microbe 20:368–380, 2016, https://doi.org/10.1016/j.chom.2016.07.015 and Martrus et al. (G. Martrus, A. Niehrs, R. Cornelis, A. Rechtien, W. García-Beltran, M. Lutgehetmann, C. Hoffmann, and M. Altfeld, J Virol 90:9018–9028, 2016, https://doi.org/10.1128/JVI.01448-16 reported using the fluorescence in situ hybridization-flow cytometry technique to identify and quantify cells expressing HIV-1 RNA and Gag protein, as well as bearing unique cell surface markers. In a recent article in mBio, Grau-Expíósito et al. (J. Grau-Expíóósito, C. Serra-Peinado, L. Miguel, J. Navarro, A. Curran, J. Burgos, I. Ocaíóóña, E. Ribera, A. Torrella, B. Planas, R. Badíóóñía, J. Castellvíóóñíí, V. Falcíóóñííó, M. Crespo, and M. J. Buzon, mBio 8:e00876-17, 2017, https://doi.org/10.1128/mBio.00876-17 reported a similar method that they claim to be more sensitive. With these methods, researchers are one step closer to measuring latent reservoirs and eliminating critical barriers to HIV eradication.

The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based magnetic resonance imaging study: the Wakayama Spine Study.

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Nagata, Keiji; Yoshimura, Noriko; Hashizume, Hiroshi; Muraki, Shigeyuki; Ishimoto, Yuyu; Yamada, Hiroshi; Takiguchi, Noboru; Nakagawa, Yukihiro; Minamide, Akihito; Oka, Hiroyuki; Kawaguchi, Hiroshi; Nakamura, Kozo; Akune, Toru; Yoshida, Munehito

2014-12-01

A narrow cervical spinal canal (CSC) is a well-known risk factor for cervical myelopathy (CM). However, no epidemiologic data of the CSC based on a population-based cohort are available. The purpose of the study was to investigate the age-related differences in CSC diameters on plain radiographs and to examine the associated magnetic resonance imaging (MRI) abnormalities including cervical cord compression and increased signal intensity (ISI) as well as the clinical CM with the narrow CSC. This was a cross-sectional study. Data were obtained from the baseline survey of the Wakayama Spine Study that was performed from 2008 to 2010 in a western part of Japan. Finally, a total of 959 subjects (319 men and 640 women; mean age, 66.4 years) were included. The outcome measures included in the study were the CSC diameter at C5 level on plain radiographs, cervical cord compression and ISI on sagittal T2-weighted MRI, and physical signs related to CM (eg, the Hoffmann reflex, hyperreflexia of the patellar tendon, the Babinski reflex, sensory and motor function, and bowel/bladder symptoms). The age-related differences of CSC diameters in men and women were investigated by descriptive statistics. The prevalence of MRI abnormalities and clinical CM was compared among the groups divided by the CSC diameter (less than 13, 13-15, and 15 mm or more). In addition, a logistic regression analysis was performed to determine the association of the CSC diameter with cervical cord compression/clinical CM after overall adjustment for age, sex, and body mass index. The CSC diameter was narrower with increasing age in both men and women. The prevalence of cervical cord compression, ISI, and the clinical CM was significantly higher in the narrower CSC group. The prevalence of cervical cord compression, ISI, and CM among subjects with CSC diameter less than 13 mm was 38.0%, 5.4%, and 10.1%, respectively. In the logistic model, the CSC diameter was a significant predictive factor for the

Reconciling radiocarbon and ice core timescales over the Holocene - Cosmogenic radionuclides as synchronization tools

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Muscheler, R.; Adolphi, F.; Mekhaldi, F.

2015-12-01

The atmospheric production rates of cosmogenic radionuclides, such as 14C and 10Be, vary globally due to external processes, namely the solar and geomagnetic modulation of the galactic cosmic ray flux as well as solar proton events. This signature is recorded in various archives such as ice cores (10Be) and tree-rings (14C). Hence, cosmogenic radionuclides offer a means to continuously assess timescale differences between two of the most widely used timescales in paleoclimatology - the radiocarbon and the ice core timescales. Short lived solar proton events additionally provide distinct marker horizons that allow synchronization of discrete horizons at annual precision. We will present a cosmogenic radionuclide based synchronization of the Greenland ice core timescale (GICC05, Svensson et al., 2008) and the radiocarbon timescale (IntCal13, Reimer et al., 2013) over the Holocene. This synchronization allows radiocarbon dated and ice core paleoclimate records to be compared on a common timescale at down to sub-decadal precision. We will compare these results to independent discrete isochrones obtained from tephrochronology and solar proton events. In addition, we will discuss implications for the accuracy and uncertainty estimates of GICC05 over the Holocene. Reimer, P. J., Bard, E., Bayliss, A., Beck, J. W., Blackwell, P. G., Bronk Ramsey, C., Buck, C. E., Cheng, H., Edwards, R. L., Friedrich, M., Grootes, P. M., Guilderson, T. P., Haflidason, H., Hajdas, I., Hatté, C., Heaton, T. J., Hoffmann, D. L., Hogg, A. G., Hughen, K. A., Kaiser, K. F., Kromer, B., Manning, S. W., Niu, M., Reimer, R. W., Richards, D. A., Scott, E. M., Southon, J. R., Staff, R. A., Turney, C. S. M., and van der Plicht, J.: IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0-50,000 Years cal BP, Radiocarbon, 55, 1869-1887, 10.2458/azu_js_rc.55.16947, 2013. Svensson, A., Andersen, K. K., Bigler, M., Clausen, H. B., Dahl-Jensen, D., Davies, S. M., Johnsen, S. J., Muscheler, R., Parrenin

Spin-Orbit Torque-Assisted Switching in Magnetic Insulator Thin Films with Perpendicular Magnetic Anisotropy

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Wu, Mingzhong

As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque that can induce magnetization switching in a neighboring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than switching using conventional spin-transfer torque. This presentation reports the SOT-assisted switching in heavy metal/magnetic insulator systems.1 The experiments made use of Pt/BaFe12O19 bi-layered structures. Thanks to its strong spin-orbit coupling, Pt has been widely used to produce pure spin currents in previous studies. BaFe12O19 is an M-type barium hexagonal ferrite and is often referred as BaM. It is one of the few magnetic insulators with strong magneto-crystalline anisotropy and shows an effective uniaxial anisotropy field of about 17 kOe. It's found that the switching response in the BaM film strongly depends on the charge current applied to the Pt film. When a constant magnetic field is applied in the film plane, the charge current in the Pt film can switch the normal component of the magnetization (M⊥) in the BaM film between the up and down states. The current also dictates the up and down states of the remnant magnetization when the in-plane field is reduced to zero. When M⊥ is measured by sweeping an in-plane field, the response manifests itself as a hysteresis loop, which evolves in a completely opposite manner if the sign of the charge current is flipped. When the coercivity is measured by sweeping an out-of-plane field, its value can be reduced or increased by as much as about 500 Oe if an appropriate charge current is applied. 1. P. Li, T. Liu, H. Chang, A. Kalitsov, W. Zhang, G. Csaba, W. Li, D. Richardson, A. Demann, G. Rimal, H. Dey, J. S. Jiang, W. Porod, S. Field, J. Tang, M. C. Marconi, A. Hoffmann, O. Mryasov, and M. Wu, Nature Commun. 7:12688 doi: 10.1038/ncomms12688 (2016).

JOSIP KOZARAC IN CROATIAN CHILDREN’S LITERATURE

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Berislav Majhut

2017-01-01

Full Text Available Josip Kozarac (1858–1906 is considered to be one of the most important Slavonian and Croatian writers of Realism. However, the beginnings of his literary work written for children are seldom mentioned and even less frequently studied. Indeed, a few remarks about that part of Kozarac’s literary work disagree on which stories belong to The Tales of Grandfather Niko (Priče djeda Nike. Such an attitude towards what constitutes the corpus of Kozarac’s work under this title is closely linked to the issue of the affiliation of these stories to children’s literature. This study attempts to provide answers to two intertwined questions: first, do Priče djeda Nike (The Tales of Grandfather Niko belong to children’s literature and second, what is the exact scope of the work known as Priče djeda Nike? Having established that Priče djeda Nike undoubtedly belong to children’s literature, we will try to find their place in the history of Croatian children’s literature. We will argue that this work represents a transitory form of narration between, on the one hand, moralistic stories (which we find in the very popular translations of the stories by German authors Christoph Schmid and Franz Hoffmann and their Croatian epigones and, on the other, entrepreneurship narratives by Davorin Trstenjak, U radu je spas (Labor Will Save Us from 1885 and Dragoslav Heiligstein, Zlatne ruke (Golden Hands from 1930, which paved the way for socially engaged realistic novels, such as Mato Lovrak’s Vlak u snijegu (A Train in the Snow published in 1933 and Družba Pere Kvržice (Pero Kvržica’s Gang published in 1933, and Josip Pavičić’s Poletarci, published in 1937. The study will show that the number of stories published in the first monographic edition of Priče djeda Nike is different from the number of stories published in Pučke novine. The study also analyzes which stories Kozarac himself considered as those belonging to Priče djeda Nike.

THE USE OF NARRATIVES IN SCIENCE COMMUNICATION: An example of the use of comic strips (narratives) in communicating scientific information about sustainable development.

Science.gov (United States)

Negrete, Aquiles

2015-04-01

It is quite reasonable to claim that narratives can include, explain and recreate science and that this means of science communication is generally popular. This idea seems to be supported by the fact that many contemporary authors who include science as a theme in their work receive a good reception among the public (at least in Britain). Novels like Fermat's Last Theorem by Simon Singh, Longitude by Dava Sobel and Neuromancer by William Gibson stayed on the best seller lists for weeks. Plays like Copenhagen by Michael Frayn, Arcadia by Tom Stoppard, Oxigen by Carl Djerassi and Ronald Hoffmann, Diary of a steak by Deborah Levy as well as Blue heart by Caryl Churchill enjoyed complete sell-outs in London and other cities in Britain. The explanation for this popularity seems to be that narratives are amusing, attractive, and interesting. Therefore, we can maintain that they are popular. But are they also a long-lasting way of transmitting knowledge? Do people remember scientific information conveyed by this means better than they remember the traditional formats like paradigmatic textbooks? These are questions that need to be addressed. To understand how narratives organize, represent and convey information, it is an important task to evaluate the advantages that this media offers for the communication of science. Narratives include several characteristics that make them memorable, understandable, enjoyable and a good way to present and communicate knowledge. Some of these attributes are achieved through narrative structures, including literary devices. In this research I discuss how the general public is familiar with the narrative structure of a story, how schemas for these narrative structures allow identification, induce emotions and promote understanding - important elements for the learning and memory process. I also look at how individually the narrative resources (or literary devices), in addition to their aesthetic value, can also work as mnemonic

Vegetation-Induced Roughness in Low-Reynold's Number Flows

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Piercy, C. D.; Wynn, T. M.

2008-12-01

Wetlands are important ecosystems, providing habitat for wildlife and fish and shellfish production, water storage, erosion control, and water quality improvement and preservation. Models to estimate hydraulic resistance due to vegetation in emergent wetlands are crucial to good wetland design and analysis. The goal of this project is to improve modeling of emergent wetlands by linking properties of the vegetation to flow. Existing resistance equations such as Hoffmann (2004), Kadlec (1990), Moghadam and Kouwen (1997), Nepf (1999), and Stone and Shen (2002) were evaluated. A large outdoor vegetated flume was constructed at the Price's Fork Research Center near Blacksburg, Virginia to measure flow and water surface slope through woolgrass (Scirpus cyperinus), a common native emergent wetland plant. Measurements of clump and stem density, diameter, and volume, blockage factor, and stiffness were made after each set of flume runs. Flow rates through the flume were low (3-4 L/s) resulting in very low stem-Reynold's numbers (15-102). Since experimental flow conditions were in the laminar to transitional range, most of the models considered did not predict velocity or stage accurately except for conditions in which the stem-Reynold's number approached 100. At low stem-Reynold's numbers (drag coefficient is inversely proportional to the Reynold's number and can vary greatly with flow conditions. Most of the models considered assumed a stem-Reynold's number in the 100-105 range in which the drag coefficient is relatively constant and as a result did not predict velocity or stage accurately except for conditions in which the stem-Reynold's number approached 100. The only model that accurately predicted stem layer velocity was the Kadlec (1990) model since it does not make assumptions about flow regime; instead, the parameters are adjusted according to the site conditions. Future work includes relating the parameters used to fit the Kadlec (1990) model to measured vegetation

Conceptual DFT: the chemical relevance of higher response functions.

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Geerlings, P; De Proft, F

2008-06-07

In recent years conceptual density functional theory offered a perspective for the interpretation/prediction of experimental/theoretical reactivity data on the basis of a series of response functions to perturbations in the number of electrons and/or external potential. This approach has enabled the sharp definition and computation, from first principles, of a series of well-known but sometimes vaguely defined chemical concepts such as electronegativity and hardness. In this contribution, a short overview of the shortcomings of the simplest, first order response functions is illustrated leading to a description of chemical bonding in a covalent interaction in terms of interacting atoms or groups, governed by electrostatics with the tendency to polarize bonds on the basis of electronegativity differences. The second order approach, well known until now, introduces the hardness/softness and Fukui function concepts related to polarizability and frontier MO theory, respectively. The introduction of polarizability/softness is also considered in a historical perspective in which polarizability was, with some exceptions, mainly put forward in non covalent interactions. A particular series of response functions, arising when the changes in the external potential are solely provoked by changes in nuclear configurations (the "R-analogues") are also systematically considered. The main part of the contribution is devoted to third order response functions which, at first sight, may be expected not to yield chemically significant information, as turns out to be for the hyperhardness. A counterexample is the dual descriptor and its R analogue, the initial hardness response, which turns out to yield a firm basis to regain the Woodward-Hoffmann rules for pericyclic reactions based on a density-only basis, i.e. without involving the phase, sign, symmetry of the wavefunction. Even the second order nonlinear response functions are shown possibly to bear interesting information, e

Avaliação parasitológica de alfaces (Lactuca sativa comercializadas em feiras livres e supermercados do município de Campo Mourão, Estado do Paraná - DOI: 10.4025/actascibiolsci.v26i4.1514 Occurence of parasites in lettuce (Lactuca sativa commercializaed in the street markets and supermarkets of Campo Mourão, state of Paraná, Brazil - DOI: 10.4025/actascibiolsci.v26i4.1514

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Sandra Maria Simonelli

2004-04-01

Full Text Available Este estudo investigou e comparou a contaminação por enteroparasitas em alfaces (Lactuca sativa comercializadas em supermercados e feiras livres do município de Campo Mourão, Estado do Paraná. Foram analisadas 150 amostras de alfaces, pelo método de sedimentação espontânea (Hoffmann, sendo 75 amostras provenientes de supermercados e 75 amostras de feiras livres. O sedimento foi analisado em microscópio óptico. Das amostras analisadas, 56% (42/75 e 58,7% (44/75 apresentaram contaminação por parasitas, dos supermercados e feiras livres, respectivamente. Os principais parasitas encontrados em supermercados foram: Ascaris spp 54,7%, Toxocara spp 2,4%, Strongyloides spp 4,8%, Entamoeba spp 35,7% e Taenia spp 2,4%; e em feiras livres foram: Ascaris spp 13,6%, Strongyloides spp 11,4%, Entamoeba spp 47,7%, Ancylostoma spp 9,1%, /em>Taenia spp 2,3%, Fasciola hepatica 6,8% e Trichuris spp 9,1%. Esses resultados indicam que as amostras de alfaces estão em desacordo com a legislação vigente e salientam a necessidade de aplicação de um programa de educação sanitária direcionado a horticultores e manipuladores de hortaliçasThis work researched and compared the contamination by enteroparasites in lettuce (Lactuca sativa commercialized in the supermarkets and street markets of Campo Mourão, State of Paraná. 150 samples of lettuce were analyzed through sedimentation method (Hoffmam, being 75 samples from supermarkets and 75 from street markets. The sediment was analyzed in optic microscope. The supermarkets samples showed contamination by parasites of 56% (42/75; while contamination of street markets samples showed 58.7% (44/75. The principal parasites observed in supermarkets samples were: Ascaris spp 54.7%, Toxocara spp 2.4%, Strongyloides spp 4.8%, Entamoeba spp 35.7% and Taenia spp 2.4%. Important parasites observed in street markets were: Ascaris spp 13.6%, Strongyloides spp 11.4%, Entamoeba spp 47.7%, Ancylostoma spp 9.1%, Taenia

Ferromagnet / superconductor oxide superlattices

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Santamaria, Jacobo

2006-03-01

The growth of heterostructures combining oxide materials is a new strategy to design novel artificial multifunctional materials with interesting behaviors ruled by the interface. With the (re)discovery of colossal magnetoresistance (CMR) materials, there has been renewed interest in heterostructures involving oxide superconductors and CMR ferromagnets where ferromagnetism (F) and superconductivity (S) compete within nanometric distances from the interface. In F/S/F structures involving oxides, interfaces are especially complex and various factors like interface disorder and roughness, epitaxial strain, polarity mismatch etc., are responsible for depressed magnetic and superconducting properties at the interface over nanometer length scales. In this talk I will focus in F/S/F structures made of YBa2Cu3O7 (YBCO) and La0.7Ca0.3MnO3 (LCMO). The high degree of spin polarization of the LCMO conduction band, together with the d-wave superconductivity of the YBCO make this F/S system an adequate candidate for the search of novel spin dependent effects in transport. We show that superconductivity at the interface is depressed by various factors like charge transfer, spin injection or ferromagnetic superconducting proximity effect. I will present experiments to examine the characteristic distances of the various mechanisms of superconductivity depression. In particular, I will discuss that the critical temperature of the superconductor depends on the relative orientation of the magnetization of the F layers, giving rise to a new giant magnetoresistance effect which might be of interest for spintronic applications. Work done in collaboration with V. Peña^1, Z. Sefrioui^1, J. Garcia-Barriocanal^1, C. Visani^1, D. Arias^1, C. Leon^1 , N. Nemes^2, M. Garcia Hernandez^2, S. G. E. te Velthuis^3, A. Hoffmann^3, M. Varela^4, S. J. Pennycook^4. Work supported by MCYT MAT 2005-06024, CAM GR- MAT-0771/2004, UCM PR3/04-12399 Work at Argonne supported by the Department of Energy, Basic

Motor-neuron pool excitability of the lower leg muscles after acute lateral ankle sprain.

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Klykken, Lindsey W; Pietrosimone, Brian G; Kim, Kyung-Min; Ingersoll, Christopher D; Hertel, Jay

2011-01-01

Neuromuscular deficits in leg muscles that are associated with arthrogenic muscle inhibition have been reported in people with chronic ankle instability, yet whether these neuromuscular alterations are present in individuals with acute sprains is unknown. To compare the effect of acute lateral ankle sprain on the motor-neuron pool excitability (MNPE) of injured leg muscles with that of uninjured contralateral leg muscles and the leg muscles of healthy controls. Case-control study. Laboratory. Ten individuals with acute ankle sprains (6 females, 4 males; age= 19.2 ± 3.8 years, height= 169.4 ± 8.5 cm, mass= 66.3 ± 11.6 kg) and 10 healthy individuals(6 females,4 males; age= 20.6 ± 4.0 years, height = 169.9 ± 10.6 cm, mass= 66.3 ± 10.2 kg) participated. The independent variables were group (acute ankle sprain, healthy) and limb (injured, uninjured). Separate dependent t tests were used to determine differences in MNPE between legs. The MNPE of the soleus, fibularis longus, and tibialis anterior was measured by the maximal Hoffmann reflex (H(max)) and maximal muscle response (M(max)) and was then normalized using the H(max):M(max) ratio. The soleus MNPE in the ankle-sprain group was higher in the injured limb (H(max):M(max) = 0.63; 95% confidence interval [Cl],0.46, 0.80) than the uninjured limb (H(max):M(max) = 0.47; 95%Cl, 0.08, 0.93)(t(6) = 3.62,P =.01).In the acute ankle-sprain group, tibialis anterior MNPE tended to be lower in the injured ankle (H(max):M(max) =0.06; 95% Cl, 0.01, 0.10) than in the uninjured ankle (H(max):M(max) =0.22; 95%Cl, 0.09, 0.35),but this finding was not different (t(9) =-2.01, P =.07). No differences were detected between injured (0.22; 95% Cl, 0.14, 0.29) and uninjured (0.25; 95%Cl, 0.12, 0.38) ankles for the fibularis longus in the ankle-sprain group (t(9) =-0.739, P =.48). We found no side-to-side differences in any muscle among the healthy group. Facilitated MNPE was present in the involved soleus muscle of patients with acute

Combined use of drugs inhibiting the renin–angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents

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Dörks M

2018-05-01

Full Text Available Michael Dörks,1 Stefan Herget-Rosenthal,2 Falk Hoffmann,1 Kathrin Jobski1 1Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; 2Department of Medicine, Rotes Kreuz Krankenhaus, Bremen, Germany Background/aims: In 2012, the European Medicines Agency reviewed the safety of dual renin–angiotensin system (RAS blockade because of potentially increased risks for inter alia acute kidney injury (AKI. Since residents of nursing homes are particularly vulnerable to adverse drug outcomes, the aims of our study were to describe RAS-inhibiting drug use in German nursing home residents and examine the risk of AKI associated with dual RAS blockade.Methods: Based on claims data, a nested case-control study within a cohort of RAS-inhibiting drug users was conducted. Using conditional logistic regression, confounder-adjusted odds ratios (aORs and 95% confidence intervals (CI were obtained for the risk of AKI associated with dual RAS blockade. Subgroup analyses were performed in patients with diabetes or chronic kidney disease and both comorbidities.Results: Of all 127,227 nursing home residents, the study cohort included 64,567 (50.7% who were treated with at least one RAS-inhibiting drug. More than three quarters of the study population were female (77.1%. Mean age was 86.0 ± 6.8 years. Most residents were treated with angiotensin-converting enzyme inhibitors (77.8%, followed by angiotensin II receptor blockers (21.6% and aliskiren (0.2%. Annual prevalence of dual RAS blockade declined from 9.6 (95% CI 7.8–11.8 in 2010 to 4.7 (95% CI 4.0–5.4 per 1,000 users in 2014. In the overall cohort, AKI was not significantly associated with dual RAS blockade (aOR 1.99; 0.77–5.17. However, significantly increased aORs were observed when considering patients with diabetes (3.47; 1.27–9.47, chronic kidney disease (4.74; 1.24–18.13 or both (11.17; 2.65–47.15.Conclusions: Prescribing of drugs inhibiting the RAS is

Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study.

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Zanobetti, Antonella; Luttmann-Gibson, Heike; Horton, Edward S; Cohen, Allison; Coull, Brent A; Hoffmann, Barbara; Schwartz, Joel D; Mittleman, Murray A; Li, Yongsheng; Stone, Peter H; de Souza, Celine; Lamparello, Brooke; Koutrakis, Petros; Gold, Diane R

2014-03-01

-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. 2014. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environ Health Perspect 122:242-248; http://dx.doi.org/10.1289/ehp.1206136.

Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study.

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Tzivian, Lilian; Dlugaj, Martha; Winkler, Angela; Weinmayr, Gudrun; Hennig, Frauke; Fuks, Kateryna B; Vossoughi, Mohammad; Schikowski, Tamara; Weimar, Christian; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Hoffmann, Barbara

2016-09-01

Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been proposed, but investigations of simultaneous exposure to noise are scarce. We analyzed the cross-sectional associations of long-term exposure to AP and traffic noise with overall MCI and amnestic (aMCI) and nonamnestic (naMCI) MCI. At the second examination of the population-based Heinz Nixdorf Recall study, cognitive assessment was completed in 4,086 participants who were 50-80 years old. Of these, 592 participants were diagnosed as having MCI (aMCI, n = 309; naMCI, n = 283) according to previously published criteria using five neuropsychological subtests. We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression, and for traffic noise [weighted 24-hr (LDEN) and night-time (LNIGHT) means]. Logistic regression models adjusted for individual risk factors were calculated to estimate the association of environmental exposures with MCI in single- and two-exposure models. Most air pollutants and traffic noise were associated with overall MCI and aMCI. For example, an interquartile range increase in PM2.5 and a 10 A-weighted decibel [dB(A)] increase in LDEN were associated with overall MCI as follows [odds ratio (95% confidence interval)]: 1.16 (1.05, 1.27) and 1.40 (1.03, 1.91), respectively, and with aMCI as follows: 1.22 (1.08, 1.38) and 1.53 (1.05, 2.24), respectively. In two-exposure models, AP and noise associations were attenuated [e.g., for aMCI, PM2.5 1.13 (0.98, 1.30) and LDEN 1.46 (1.11, 1.92)]. Long-term exposures to air pollution and traffic noise were positively associated with MCI, mainly with the amnestic subtype. Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall study

Cross-market cost-effectiveness analysis of erlotinib as first-line maintenance treatment for patients with stable non-small cell lung cancer

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Vergnenègre A

2012-01-01

Full Text Available Alain Vergnenègre1, Joshua A Ray2, Christos Chouaid3, Francesco Grossi4, Helge G Bischoff5, David F Heigener6, Stefan Walzer21Department of Pneumology, Hôpital du Cluzeau, Limoges, France; 2Global Health Economics and Strategic Pricing, F Hoffmann-La Roche Ltd, Basel, Switzerland; 3Respiratory Service, Hôpital Saint Antoine, Paris, France; 4Lung Cancer Unit, National Institute for Cancer Research, Genoa, Italy; 5Thoracic Oncology, Onkologie Thoraxklinik Heidelberg, Heidelberg, Germany; 6Department of Thoracic Oncology, Krankenhaus Großhansdorf, Großhansdorf, GermanyBackground: Platinum-doublet, first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC is limited to 4–6 cycles. An alternative strategy used to prolong the duration of first-line treatment and extend survival in metastatic NSCLC is first-line maintenance therapy. Erlotinib was approved for first-line maintenance in a stable disease population following results from a randomized, controlled Phase III trial comparing erlotinib with best supportive care. We aimed to estimate the incremental cost-effectiveness of erlotinib 150 mg/day versus best supportive care when used as first-line maintenance therapy for patients with locally advanced or metastatic NSCLC and stable disease.Methods: An economic decision model was developed using patient-level data for progression-free survival and overall survival from the SATURN (SequentiAl Tarceva in UnResectable NSCLC study. An area under the curve model was developed; all patients entered the model in the progression-free survival health state and, after each month, moved to progression or death. A time horizon of 5 years was used. The model was conducted from the perspective of national health care payers in France, Germany, and Italy. Probabilistic sensitivity analyses were performed.Results: Treatment with erlotinib in first-line maintenance resulted in a mean life expectancy of 1.39 years in all countries

Favorable effects on arterial stiffness after renal sympathetic denervation for the treatment of resistant hypertension: a cardiovascular magnetic resonance study

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Hammer TA

2016-09-01

Full Text Available Tommy Arild Hammer,1 Knut Asbjørn Rise Langlo,2 Pål Erik Goa,1,3 Fadl Elmula M Fadl Elmula,4,5 Pavel Hoffmann,6 Knut Haakon Stensaeth1,7 1Department of Radiology and Nuclear Medicine, 2Department of Nephrology, St Olav’s University Hospital, Trondheim, Norway; 3Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway; 4Institute of Cardiovascular and Renal Research, Department of Cardiology, Oslo University Hospital, Oslo, Norway; 5Faculty of Clinical Medicine, University of Oslo, Oslo, Norway; 6Department of Cardiology, Oslo University Hospital, Oslo, Norway; 7Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway Aims: Renal sympathetic denervation (RDN has recently been suggested to be a novel treatment strategy for patients with treatment-resistant hypertension. However, the latest randomized studies have provided conflicting results and the influence of RDN on arterial stiffness remains unclear. Therefore, this study aimed to detect the effects of RDN on arterial stiffness as measured with aortic pulse wave velocity (PWV and distensibility in addition to cardiac function and T1 mapping at baseline and at 6-month follow-up.Methods: RDN was performed in a total of 16 patients with treatment-resistant hypertension, and the procedures were conducted at two university hospitals using two different RDN devices. All patients and age-matched controls underwent a comprehensive clinical examination and cardiac magnetic resonance protocols both at baseline and at a 6-month follow-up.Results: In the treatment group, the systolic blood pressure (SBP was found to be decreased at the follow-up visit (office SBP; 173±24 compared to 164±25 mmHg [P= 0.033], the 24-hour ambulatory SBP had decreased (163±25 compared to 153±20 mmHg [P=0.057], the aortic PWV had decreased from 8.24±3.34 to 6.54±1.31 m/s (P=0.053, and the aortic distensibility had increased from 2

Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

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Liang Y

2016-05-01

Full Text Available Yayun Liang,1 Benford Mafuvadze,1 Johannes D Aebi,2 Salman M Hyder1 1Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA; 2Medicinal Chemistry, Roche Pharma Research and Early Development (pRED, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland Abstract: Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration; however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylaminohexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071 (RO, which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway, on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the

Diagnóstico diferencial das distrofias musculares com referência especial às alterações enzimáticas

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H. Heick

1967-06-01

Full Text Available Depois de apresentar os dados clínicos e genéticos relativos a 221 casos de distrofia muscular progressiva (125 casos do tipo Duchenne, 63 do tipo cintura pélvica e 25 do tipo fácio-escápulo-umeral, os autores analisam os resultados das dosagens sôro-enzimáticas que fizeram; em alguns casos foram pesquisas também as atividades de 25 enzimas em homogeneizados de tecido muscular. Os mesmos exames foram feitos em casos de miopatias de outra etiologia e de distrofias musculares neuropáticas e mielopáticas. Foi verificado que o teor das sôro-enzimas aumenta em todas as formas de distrofia muscular progressiva hereditária. No tipo Duchenne as-atividades enzimáticas são elevadas desde o nascimento das crianças acometidas, precedendo o aparecimento da sintomatologia clínica. Com o progredir da moléstia e com o decorrer dos anos os teores sôro-enzimáticos tendem a diminuir, podendo reduzir-se aos valores normais nas fases finais da moléstia. No tecido muscular não existe diferença significante, no que respeita à composição enzimática, entre os diversos tipos de distrofia muscular progressiva e hereditária. Com exceção de poucas enzimas cuja atividade é maior nos tecidos conjuntivo e adiposo que progressivamente substituem o tecido muscular que entra em atrofia, o teor das mio-enzimas diminui com o progredir da moléstia, como expressão do crescente esgotamento do citoplasma da célula muscular. Nas distrofias musculares neuropáticas e mielopáticas as alterações são idênticas, embora de menor intensidade. Algumas diferenças quantitativas podem ser explicadas pela idade dos pacientes e pela intensidade do processo. A mesma diferença pode ser demonstrada mediante exames histopatológicos: nas formas que acometem crianças (Werdnig-Hoffmann as fibras musculares ainda não denervadas se apresentam com aspecto normal, ao passo que, nas formas do adulto (Kugelberg-Welander, possivelmente pelo desgaste provocado pelos esfor

Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease

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Hoffmann M

2017-11-01

Full Text Available Martin Hoffmann,1 Dina Siebrasse,1 Erik Schlöricke,2 Ralf Bouchard,1 Tobias Keck,1 Claudia Benecke1 1Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, 2Department of Surgery, Westküstenklinikum Heide, Heide, Germany Aim: To investigate, via data analysis, the long-term outcome of patients who underwent either laparoscopic or open surgery for Crohn’s disease.Methods: A total of 113 patients who had undergone first abdominal surgery due to Crohn’s disease between January 2000 and December 2010 in a maximum care provider facility, were included in the statistical analysis. All patients provided their informed consent prior to inclusion. Data were collected from a database. Follow-up data included data from central mortality registries, general practitioners and a specialized clinic. Statistical analysis of the general patient data and the different operations and approaches were performed with the use of chi-square test, Fisher’s exact test, and the Mann–Whitney U test.Results: The median follow-up period in case of open and laparoscopic surgery was found to be 9 and 6 years, respectively. Statistically significant differences were observed for the following parameters in case of open and laparoscopic surgery, respectively: age (median=44 vs. 36 years, range=15–76 vs. 15–72 years; p=0.007, urgency of operation (23 out of 34 planned vs. 6 out of 70 planned; p<0.001, year of resection (median=2003 vs. 2006, range=2000–2010 vs. 2000–2010; p=0.001. The length of stay in hospital was significantly shorter in the laparoscopic group than that of open surgery group (8 vs. 11 days, respectively; p<0.0001. We did not control for factors such as age and comorbidities in our statistical analysis. We also did not find any differences with regard to perioperative and 90-day mortality, surgical complications, length of specimen, stoma, surgical recurrence rate (10% in both groups and number of re

The Hydrometallurgical Extraction and Recovery of High-Purity Silver

Science.gov (United States)

Hoffmann, James E.

2012-06-01

-bearing inputs, will be described in detail to demonstrate how typical chemical engineering unit process and unit operations have supplanted classic smelting and fire refining techniques. The Kennecott Copper Company, which has operated a hydrometallurgical circuit successfully for the recovery of high-purity silver from the slimes wet chlorination residue, has permitted me to provide some operation information and results using the technology. Both Phelps Dodge and Kennecott should be recognized for their forward-looking attitude in undertaking the conversion of conceptual chemistry into successful, full-scale plants. The process as employed at Phelps Dodge is discussed at length in reference (J.E. Hoffmann and B. Wesstrom: Hydrometallurgy, 1994, vol. 94, pp. 69-105).

Editorial v. 4, n. 3

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Júlio Araujo Carneiro da Cunha

2016-01-01

Full Text Available O ano de 2015 foi marcado por avanços e mudanças na PODIUM Sport, Leisure and Tourism Review. Numa retrospectiva dos indicadores da revista ao longo do ano, tivemos 23 artigos publicados em três edições. Houve 67 autores que representaram 21 instituições de ensino do país, além de outras duas universidades estrangeiras. Pudemos contar também com diversos avaliadores ad hoc que atuaram com pareceres aos trabalhos submetidos à revista ao longo deste ano. Aproveito a oportunidade para agradecer mais uma vez o trabalho voluntário desses pareceristas que ajudam a incrementar a qualidade dos trabalhos da revista, o que sustenta o avanço das áreas de Gestão do Esporte, Lazer e Turismo com um conhecimento cada vez mais robusto. A partir de outubro de 2015 a revista PODIUM Sport, Leisure and Tourism Review contou com mudanças da sua equipe editorial. Assumi a chefia editorial da revista juntamente com o suporte do Diego Janes, novo assistente editorial da revista. Trabalhamos juntos com o assistente editorial Altieres de Oliveira Silva que continua a apoiar a Podium. Aproveito a oportunidade para agradecer ao prof. João Manuel Casquinha Malaia Santos pelos serviços prestados até aqui como editor-chefe da revista e também à Camila de Oliveira Prado pelo apoio oferecido como assistente editorial nesse mesmo período. Os trabalhos prestados por eles devem ser enaltecidos porque foram, sem dúvida, fundamentais para a estruturação da revista e pela legitimação dela perante a comunidade acadêmica. Diante desses novos desafios, apresento os sete trabalhos publicados nesse último número de 2015 da Podium. O primeiro artigo leva o título de “O papel do envolvimento e do orgulho nas decisões de consumo de pacotes de preços: um estudo com ingressos de futebol no Brasil” e tem como autoria Claudio Hoffmann Sampaio, Jefferson Dobner Sordi e Marcelo Gattermann Perin. Neste estudo, os autores identificaram o quanto os pacotes de pre

Adaptation response surfaces from an ensemble of wheat projections under climate change in Europe

Science.gov (United States)

Ruiz-Ramos, Margarita; Ferrise, Roberto

2016-04-01

preliminary ARSs show some adaptation options allow recover up to ca. 2000 kg/ha. Compared to the historical yields recorded at Lleida province (2550 kg/ha in 1981-2010) our results indicate that adaptation is feasible and may help to reduce detrimental effects of CC. Our analysis evaluates if the explored adaptations fulfill the biophysical requirements to become a practical adaptive solution. This study exemplifies how adaptation options and their impacts can be analyzed, evaluated and communicated in a context of high regional uncertainty for current and future conditions and for short to long-term perspective. This work was funded by MACSUR project within FACCE-JPI. References Abeledo, L.G., R. Savin and G.A. Slafer (2008). European Journal of Agronomy 28:541-550. Cartelle, J., A. Pedró, R. Savin, G.A. Slafer (2006) European Journal of Agronomy 25:365-371. Pirttioja, N., T. Carter, S. Fronzek, M. Bindi, H. Hoffmann, T. Palosuo, M. Ruiz-Ramos, F. Tao, M. Acutis, S. Asseng, P. Baranowski, B. Basso, P. Bodin, S. Buis, D. Cammarano, P. Deligios, M.-F. Destain, B. Dumont, R. Ewert, R. Ferrise, L. François, T. Gaiser, P. Hlavinka, I. Jacquemin, K.C. Kersebaum, C. Kollas, J. Krzyszczak, I.J. Lorite, J. Minet, M.I. Minguez, M. Montesino, M. Moriondo, C. Müller, C. Nendel, I. Öztürk, A. Perego, A. Rodríguez, A.C. Ruane, F. Ruget, M. Sanna, M.A. Semenov, C. Slawinski, P. Stratonovitch, I. Supit, K. Waha, E. Wang, L. Wu, Z. Zhao, and R.P. Rötter, 2015: A crop model ensemble analysis of temperature and precipitation effects on wheat yield across a European transect using impact response surfaces. Clim. Res., 65, 87-105, doi:10.3354/cr01322. IRS2 TEAM: Alfredo Rodríguez(1), Ignacio J. Lorite(3), Fulu Tao(4), Nina Pirttioja(5), Stefan Fronzek(5), Taru Palosuo(4), Timothy R. Carter(5), Marco Bindi(2), Jukka G Höhn(4), Kurt Christian Kersebaum(6), Miroslav Trnka(7,8), Holger Hoffmann(9), Piotr Baranowski(10), Samuel Buis(11), Davide Cammarano(12), Yi Chen(13,4), Paola Deligios

Deciphering Selectivity in Organic Reactions: A Multifaceted Problem.

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Balcells, David; Clot, Eric; Eisenstein, Odile; Nova, Ainara; Perrin, Lionel

2016-05-17

Computational chemistry has made a sustained contribution to the understanding of chemical reactions. In earlier times, half a century ago, the goal was to distinguish allowed from forbidden reactions (e.g., Woodward-Hoffmann rules), that is, reactions with low or high to very high activation barriers. A great achievement of computational chemistry was also to contribute to the determination of structures with the bonus of proposing a rationalization (e.g., anomeric effect, isolobal analogy, Gillespie valence shell pair electron repulsion rules and counter examples, Wade-Mingos rules for molecular clusters). With the development of new methods and the constant increase in computing power, computational chemists move to more challenging problems, close to the daily concerns of the experimental chemists, in determining the factors that make a reaction both efficient and selective: a key issue in organic synthesis. For this purpose, experimental chemists use advanced synthetic and analytical techniques to which computational chemists added other ways of determining reaction pathways. The transition states and intermediates contributing to the transformation of reactants into the desired and undesired products can now be determined, including their geometries, energies, charges, spin densities, spectroscopy properties, etc. Such studies remain challenging due to the large number of chemical species commonly present in the reactive media whose role may have to be determined. Calculating chemical systems as they are in the experiment is not always possible, bringing its own share of complexity through the large number of atoms and the associated large number of conformers to consider. Modeling the chemical species with smaller systems is an alternative that historically led to artifacts. Another important topic is the choice of the computational method. While DFT is widely used, the vast diversity of functionals available is both an opportunity and a challenge. Though

Cellular prion protein is required for neuritogenesis: fine-tuning of multiple signaling pathways involved in focal adhesions and actin cytoskeleton dynamics

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Alleaume-Butaux A

2013-07-01

Full Text Available Aurélie Alleaume-Butaux,1,2 Caroline Dakowski,1,2 Mathéa Pietri,1,2 Sophie Mouillet-Richard,1,2 Jean-Marie Launay,3,4 Odile Kellermann,1,2 Benoit Schneider1,2 1INSERM, UMR-S 747, 2Paris Descartes University, Sorbonne Paris Cité, UMR-S 747, 3Public Hospital of Paris, Department of Biochemistry, INSERM UMR-S 942, Lariboisière Hospital, Paris, France; 4Pharma Research Department, Hoffmann La Roche Ltd, Basel, Switzerland Abstract: Neuritogenesis is a dynamic phenomenon associated with neuronal differentiation that allows a rather spherical neuronal stem cell to develop dendrites and axon, a prerequisite for the integration and transmission of signals. The acquisition of neuronal polarity occurs in three steps: (1 neurite sprouting, which consists of the formation of buds emerging from the postmitotic neuronal soma; (2 neurite outgrowth, which represents the conversion of buds into neurites, their elongation and evolution into axon or dendrites; and (3 the stability and plasticity of neuronal polarity. In neuronal stem cells, remodeling and activation of focal adhesions (FAs associated with deep modifications of the actin cytoskeleton is a prerequisite for neurite sprouting and subsequent neurite outgrowth. A multiple set of growth factors and interactors located in the extracellular matrix and the plasma membrane orchestrate neuritogenesis by acting on intracellular signaling effectors, notably small G proteins such as RhoA, Rac, and Cdc42, which are involved in actin turnover and the dynamics of FAs. The cellular prion protein (PrPC, a glycosylphosphatidylinositol (GPI-anchored membrane protein mainly known for its role in a group of fatal neurodegenerative diseases, has emerged as a central player in neuritogenesis. Here, we review the contribution of PrPC to neuronal polarization and detail the current knowledge on the signaling pathways fine-tuned by PrPC to promote neurite sprouting, outgrowth, and maintenance. We emphasize that Pr

Laboratory Reference Spectroscopy of Icy Satellite Candidate Surface Materials (Invited)

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Dalton, J. B.; Jamieson, C. S.; Shirley, J. H.; Pitman, K. M.; Kariya, M.; Crandall, P.

2013-12-01

Pitman, 2012). We will report on recent results, including spectra of sulfate hydrates, simple organic molecules, and volatile ices measured at PICL in support of past, present and planned missions. We gratefully acknowledge the support of JPL's Research and Technology Development and Strategic Hire Programs, and of the NASA Outer Planets Research and Planetary Geology and Geophysics programs. Dalton, III, J.B., Spectroscopy of icy moon surface materials, Space Sci. Rev. 153:219-247, 2010. Dalton, III, J.B., and Pitman, K.M., Low temperature optical constants of some hydrated sulfates relevant to planetary surfaces, J. Geophys. Res. 117:E09001, doi:10.1029/2011JE004036, 2012. Hapke, B.W., Bidirectional reflectance spectroscopy I. Theory, J. Geophys. Res. 86, 3039-3054, 1981. Shkuratov, Y., L. Starukhina, H. Hoffmann, and G. Arnold, A model of spectral albedo of particulate surfaces: Implications for optical properties of the Moon, Icarus 137, 235-246, 1999.

Drug-eluting stents with biodegradable polymer for the treatment of patients with diabetes mellitus: clinical outcome at 2 years in a large population of patients

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Wiemer M

2015-02-01

Full Text Available Marcus Wiemer,1 Gian Battista Danzi,2 Nick West,3 Vassilios Voudris,4 René Koning,5 Stefan Hoffmann,6 Mario Lombardi,7 Josepa Mauri,8 Rade Babic,9 Fraser Witherow10On behalf of the NOBORI 2 Investigators 1Department of Cardiology, Heart and Diabetes Center North Rhine–Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany; 2Ospedale Maggiore Policlinico, Milan, Italy; 3Papworth Hospital, Cambridge, UK; 4Onassis Cardiac Surgery Center, Athens, Greece; 5Clinique Saint Hilaire, Rouen, France; 6Vivantes Netzwerk für Gesundheit GmbH, Berlin, Germany; 7Azienda Ospedaliera Villa Sofia, Palermo, Italy; 8Hospital Universitari Germans Trias i Pujol, Badalona, Spain; 9Institute for Cardiovascular Diseases Dedinje, Belgrade, Serbia; 10Dorset County Hospital, Dorchester, UK Objective: This study investigates the safety and efficacy of a third-generation drug-eluting stent (DES with biodegradable polymer in the complex patient population of diabetes mellitus (DM. Clinical trial registration: ISRCTN81649913. Background: Percutaneous coronary interventions in patients with DM are associated with a higher incidence of death, restenosis, and stent thrombosis as compared to non-diabetic patients. The use of a DES has been shown to improve outcomes in diabetic patients. Methods: Out of 3,067 patients, enrolled in 126 centers worldwide in the NOBORI 2 registry, 888 patients suffered from DM, 213 of them (14% being insulin-dependent DM (IDDM. Two years’ follow-up has been completed in this study. Results: At 1- and 2-year follow-up, 97% and 95% of the patients, respectively, were available. The reported target lesion failure (TLF rates at 1- and 2-year follow-up were 6.0% and 7.2% in the DM group, respectively, and 3.0% and 4.2% in the non-DM group, respectively (P<0.001 for both years. Inside the DM group, the TLF rates of 9.9% and 11.7% at the 1- and 2-year follow-ups, respectively, in patients with IDDM were significantly higher than the TLF rates of 4

Boron diffusion in strained and strain-relaxed SiGe

International Nuclear Information System (INIS)

Wang, C.C.; Sheu, Y.M.; Liu, Sally; Duffy, R.; Heringa, A.; Cowern, N.E.B.; Griffin, P.B.

2005-01-01

SiGe has been utilized for aggressive CMOS technologies development recently and there are many references [M. Shima, T. Ueno, T. Kumise, H. Shido, Y. Sakuma, S. Nakamura, Symposium on VLSI Technology Technical Digest, 2002, pp. 94-95; T. Ghani, M. Armstrong, C. Auth, M. Bost, P. Charvat, G. Glass, T. Hoffmann, K. Johnson, C. Kenyon, J. Klaus, B. McIntyre, K. Mistry, A. Murthy, J. Sandford, M. Silberstein, S. Sivakumar, P. Smith, K. Zawadzki, S. Thompson, M. Bohr, International Electron Devices Meeting Technical Digest, December 2003, pp. 978-980; P. Bai, C. Auth, S. Balakrishnan, M. Bost, R. Brain, V. Chikarmane, R. Heussner, M. Hussein, J. Hwang, D. Ingerly, R. James, J. Jeong, C. Kenyon, E. Lee, S. Lee, N. Lindert, M. Liu, Z. Ma, T. Marieb, A. Murthy, R. Nagisetty, S. Natarajan, J. Neirynck, A. Ott, C. Parker, J. Sebastian, R. Shaheed, S. Sivakumar, J. Steigerwald, S. Tyagi, C. Weber, B. Woolery, A. Yeoh, K. Zhang, M. Bohr, International Electron Devices Meeting Technical Digest, December 2004, pp. 657-660] presenting the advantages brought by it. A better understanding regarding the boron diffusion behavior within and in the vicinity of SiGe is necessary to optimize the extension and the source/drain in pMOSFET. In order to achieve the goal, both effects from mechanical strain and Ge doping on boron diffusion have been investigated. However, only a few publications discuss the impacts of both. Furthermore, most researches investigate these two effects under the conditions of low boron concentration [P. Kuo, J.L. Hoyt, J.F. Gibbons, J.E. Turner, D. Lefforge, Appl. Phys. Lett. 66 (January (5)) (1995) 580-582; N.R. Zangenberg, J. Fage-Pedersen, J. Lundsgaard Hansen, A. Nylandsted Larsen, J. Appl. Phys. 94 (September (6)) (2003) 3883-3890] and high thermal budget anneal [P. Kuo, J.L. Hoyt, J.F. Gibbons, J.E. Turner, D. Lefforge, Appl. Phys. Lett. 66 (January (5)) (1995) 580-582; N.R. Zangenberg, J. Fage-Pedersen, J. Lundsgaard Hansen, A. Nylandsted Larsen, J. Appl

Circumstances of falls and falls-related injuries in a cohort of older patients following hospital discharge

Directory of Open Access Journals (Sweden)

Hill AM

2013-06-01

Full Text Available Anne-Marie Hill,1 Tammy Hoffmann,2,3 Terry P Haines4,51School of Physiotherapy, Institute for Health Research, The University of Notre Dame Australia, Fremantle, WA, 2Centre for Research in Evidence-Based Practice, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, 3School of Health and Rehabilitation Sciences, The University of Queensland, 4School of Primary Health Care, Monash University, Melbourne, VIC, 5Allied Health Research Unit, Kingston Centre, Southern Health, Clayton, VIC, AustraliaBackground: Older people are at increased risk of falls after hospital discharge. This study aimed to describe the circumstances of falls in the six months after hospital discharge and to identify factors associated with the time and location of these falls.Methods: Participants in this randomized controlled study comprised fallers (n = 138 who were part of a prospective observational cohort (n = 343 nested within a randomized controlled trial (n = 1206. The study tested patient education on falls prevention in hospital compared with usual care in older patients who were discharged from hospital and followed for six months after hospital discharge. The outcome measures were number of falls, falls-related injuries, and the circumstances of the falls, measured by use of a diary and a monthly telephone call to each participant.Results: Participants (mean age 80.3 ± 8.7 years reported 276 falls, of which 150 (54.3% were injurious. Of the 255 falls for which there were data available about circumstances, 190 (74.5% occurred indoors and 65 (25.5% occurred in the external home environment or wider community. The most frequent time reported for falls was the morning (between 6 am and 10 am when 79 (28.6% falls, including 49 (32.7% injurious falls, occurred. The most frequently reported location for falls (n = 80, 29.0%, including injurious falls (n = 42, 28.0%, was the bedroom. Factors associated with falling in the bedroom included

Stromatolite laminae (Lagoa Vermelha, Brasil) as archives for reservoir age changes

Science.gov (United States)

Bruggmann, Sylvie; Vasconcelos, Crisogono; Hajdas, Irka

2016-04-01

.L. Edwards, M. Friedrich, P.M. Grootes, T.P. Guilderson, H. Haflidason, I. Hajdas, C. Hatté, T.J. Heaton, D.L. Hoffmann, A.G. Hogg, K.A. Hughen, K.F. Kaiser, B. Kromer, S.W. Manning, M. Niu, R.W. Reimer, D.A. Richards, E.M. Scott, J. R. Southon, R.A. Staff, C.S.M. Turney, J. van der Plicht (2013). IntCal13 and Marine13 radiocarbon age calibration curves 0-50,000 years cal BP. Radiocarbon 55(4):1869-1887. [3] A.G. Hogg, Q. Hua, P.G. Blackwell, M. Niu, C.E. Buck, T.P. Guilderson, T.J. Heaton, J.G. Palmer, P.J. Reimer, R.W. Reimer, C.S.M. Turney, S.R.H. Zimmerman (2013). Shcal13 southern hemisphere calibration, 0-50,000 years cal BP. Radiocarbon, 55(2):1-15.

Effect of ageing of K-feldspar on its ice nucleating efficiency in immersion, deposition and contact freezing modes

Science.gov (United States)

Peckhaus, Andreas; Bachmann, Felix; Hoffmann, Nadine; Koch, Michael; Kiselev, Alexei; Leisner, Thomas

2015-04-01

between freshly cleaved and aged mineral surfaces. This effect is especially pronounced for surfaces having different crystallographic orientations (001 and 010), with 001 being clearly preferential for ice nucleation. The factor two change of the BET effective area of the naturally aged feldspar particles is also indicative for the change in the surface morphology. Based on the IC analysis of framework cations removal from the surface of feldspar, we discuss the possible implications of this process for the interpretation of observed freezing behavior of feldspars. [1] Atkinson, J.D., Murray, B.J., Woodhouse, M.T., Whale, T.F., Baustian, K.J., Carslaw, K.S., Dobbie, S., O'Sullivan, D., and Malkin, T.L.: The importance of feldspar for ice nucleation by mineral dust in mixed-phase clouds. Nature, 498, 355-358, 2013 [2] Hoffmann, N., Kiselev, A., Rzesanke, D., Duft, D., and Leisner, T.: Experimental quantification of contact freezing in an electrodynamic balance. Atmos. Meas. Tech., 6, 2373-2382, 2013.

Maintenance erlotinib in advanced nonsmall cell lung cancer: cost-effectiveness in EGFR wild-type across Europe

Directory of Open Access Journals (Sweden)

Walleser S

2012-09-01

Full Text Available Silke Walleser,1 Joshua Ray,2 Helge Bischoff,3 Alain Vergnenègre,4 Hubertus Rosery,5 Christos Chouaid,6 David Heigener,7 Javier de Castro Carpeño,8 Marcello Tiseo,9 Stefan Walzer21Health Economic Consultancy, Renens, Switzerland; 2F Hoffmann-La Roche Pharmaceuticals AG, Basel, Switzerland; 3Thoracic Hospital of Heidelberg, Heidelberg, Germany; 4Limoges University Hospital, Limoges, France; 5Assessment-in-Medicine GmbH, Loerrach, Germany; 6Hospital Saint Antoine, Paris, France; 7Hospital Grosshansdorf, Grosshansdorf, Germany; 8University Hospital La Paz, Madrid, Spain; 9University Hospital of Parma, Parma, ItalyBackground: First-line maintenance erlotinib in patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC has demonstrated significant overall survival and progression-free survival benefits compared with best supportive care plus placebo, irrespective of epidermal growth factor receptor (EGFR status (SATURN trial. The cost-effectiveness of first-line maintenance erlotinib in the overall SATURN population has been assessed and published recently, but analyses according to EGFR mutation status have not been performed yet, which was the rationale for assessing the cost-effectiveness of first-line maintenance erlotinib specifically in EGFR wild-type metastatic NSCLC.Methods: The incremental cost per life-year gained of first-line maintenance erlotinib compared with best supportive care in patients with EGFR wild-type stable metastatic NSCLC was assessed for five European countries (the United Kingdom, Germany, France, Spain, and Italy with an area-under-the-curve model consisting of three health states (progression-free survival, progressive disease, death. Log-logistic survival functions were fitted to Phase III patient-level data (SATURN to model progression-free survival and overall survival. The first-line maintenance erlotinib therapy cost (modeled for time to treatment cessation, medication cost in later lines, and

Indirect treatment comparison of bevacizumab + interferon-α-2a vs tyrosine kinase inhibitors in first-line metastatic renal cell carcinoma therapy

Directory of Open Access Journals (Sweden)

Gerald HJ Mickisch

2011-01-01

Full Text Available Gerald HJ Mickisch1, Björn Schwander2, Bernard Escudier3, Joaquim Bellmunt4, José P Maroto5, Camillo Porta6, Stefan Walzer7, Uwe Siebert8,91Department of Urology, Center of Operative Urology Bremen, Bremen, Germany; 2Department of Outcomes Research, AiM GmbH Assessment-in-Medicine, Lörrach, Germany; 3Immunotherapy Unit, Institut Gustave Roussy, Villejuif, France; 4Department of Medical Oncology, University Hospital del Mar UPF, Barcelona, Spain; 5Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 6Department of Medical Oncology, IRCCS San Matteo University Hospital Foundation, Pavia, Italy; 7Global Health Economics, F Hoffmann-La Roche Pharmaceuticals AG, Basel, Switzerland; 8Department of Public Health, Medical Decision Making and Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria; 9Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USABackground: The vascular endothelial growth factor inhibitor bevacizumab (BEV given in combination with interferon-α-2a (IFN, and the tyrosine kinase inhibitors (TKIs sunitinib (SUN and pazopanib (PAZ, have all shown significant increase in progression-free survival (PFS in first-line metastatic renal-cell carcinoma (mRCC therapy. These targeted therapies are currently competing to be primary choice; hence, in the absence of direct head-to-head comparison, there is a need for valid indirect comparison assessment.Methods: Standard indirect comparison methods were applied to independent review PFS data of the pivotal Phase III trials, to determine indirect treatment comparison hazard-ratios (HR with 95% confidence intervals (95% CI. As BEV+IFN and SUN have been compared to IFN, indirect comparison was enabled by the common IFN comparator arms. As PAZ was compared to placebo (PLA, a connector trial (IFN vs PLA was required for the indirect comparison to BEV

Biogas in agriculture. Status and prospects. Proceedings; Biogas in der Landwirtschaft. Stand und Perspektiven. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the congress of the Agency for Renewable Resources (Guelzow, Federal Republic of Germany) and the Association for Technology and Structures in Agriculture (Darmstadt, Federal Republic of Germany) at 20th-21st September, 2011 in Goettingen (Federal Republic of Germany) the following lectures and posters were presented: (1) Perspectives of using biogas as a part of the German power supply (Stefan Rauh); (2) Development of biogas in Europe (Marc Fleureck); (3) Biology of methanogenic archaea and its significance for the microbial process control in biogas plants (Helmut Koenig); (4) Efficiency and behaviour of enzymes in the biogas process (Monika Heiermann); (5) Trace elements in NaWaRo biogas plants for balancing substrate limited deficiency symptoms and stabilizing the fermentation process (Hans Oechsner); (6) EEG - Actual developments for biogas (Ulrich Keymer); (7) Utilization of thermal energy from cogeneration in the practice - Experiences from the view of an environmental expert (Michael Hub); (8) Innovations in the legal aspects of the production and utilization of biogas (Hartwig von Bredow); (9) Damages and deficiencies at biogas plants (Waldemar Gruber); (10) Learning from accidents, damages and their causes as well as their correctives in the operation of biogas plants - Reports from the practice (Wolfgang Horst Stachowitz); (11) Causes and avoidance of container damages by means of biocorrosion (Jan Kuever); (12) Anaerobic degradation of cellulosic substrates - Bionic implementation of the forestomach sysem of a ruminant (Dirk Weichgrebe); (13) Fermentation of renewable raw materials in the up flow procedure (Jan Mumme); (14) Two-phase pressure fermentation for feeding into natural gas grids (Andreas Lemmer); (15) Requirements and potential of sugar beets for fermentation (Christa Hoffmann); (16) Innovation in the area of power beets (Andreas von Felde); (17) Optimization of manuring with fermentation residues in order to reduce the nitrogen

Mode Equivalence of Health Indicators Between Data Collection Modes and Mixed-Mode Survey Designs in Population-Based Health Interview Surveys for Children and Adolescents: Methodological Study.

Science.gov (United States)

Mauz, Elvira; Hoffmann, Robert; Houben, Robin; Krause, Laura; Kamtsiuris, Panagiotis; Gößwald, Antje

2018-03-05

children and adolescents were compared by survey design and data collection mode by calculating predictive margins from regression models. There were no statistically significant differences in sociodemographic characteristics or health indicators between the single-mode control group and any of the mixed-mode survey designs. Differences in sociodemographic characteristics between SAQ-Web and SAQ-paper were found. Web respondents were more likely to be male, have higher levels of education, and higher household income compared with paper respondents. After adjusting for sociodemographic characteristics, only one of the 38 analyzed health indicators showed different prevalence rates between the data collection modes, with a higher prevalence rate for lifetime alcohol consumption among the online-responding adolescents (Pdesign with Web-based and paper questionnaires. ©Elvira Mauz, Robert Hoffmann, Robin Houben, Laura Krause, Panagiotis Kamtsiuris, Antje Gößwald. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 05.03.2018.

Regionalism and political pepresentation in comparativeperspective: the European Union and MERCOSUL

Directory of Open Access Journals (Sweden)

Ana Paula Tostes

2013-12-01

in the integration process. The dialogue with different points of view will be fundamental, especially in order to draft analytical dimensions of the impact of the changes that occurred with the emergence of a new form of regional representation (FAWCETT; HURRELL, 2003; MALAMUD; SOUZA, 2005; DRI, 2009; 2010; LINDBERG, 1963. Could an extra form of representation come at a cost of the suppression of less opportunity for participation? In the third section, the relation between representation and sovereignty is evaluated, as well as the role of representative institutions in policy making (KEOHANE; HOFFMANN, 1991; RITTBERGER, 2012; JACOB, 2007. In this section, the experience of the European Parliament will shed light on the analysis of the constitution of a representative institution on a regional level, such as the one expected by the PARLASUL. Finally, the article traces a few conclusions on representation in the context of regional integration processes and the importance of information and social awareness of such processes as a measure of democratic legitimacy.

Undergraduate Science Students are Uncertain of How to Find Facts in E-books Compared to Print Books. A Review of: Berg, S. A., Hoffmann, K., & Dawson, D. (2010. Not on the same page: Undergraduates' information retrieval in electronic and print books. The Journal of Academic Librarianship, 36(6, 518-525.

Directory of Open Access Journals (Sweden)

Christina E. Carter

2011-06-01

Full Text Available Objective – To observe and compare the strategies that undergraduate science students use to perform information retrieval tasks in e-books and in print books.Design – Qualitative analysis, employing a “prompted think-aloud” methodology and thematic analysis.Setting – Taylor Library (serving the Faculty of Science, University of Western Ontario, London, Ontario, Canada.Subjects – Twenty undergraduate science students (11 females, 9 males who had completed at least two years of study in Faculty of Science programs at the University of Western Ontario.Methods – Participants for the study were recruited through informational posters in Taylor Library, science departments, and in undergraduate science classes. Participants were assigned fact-finding tasks in e-book and print versions of eight health, computer science, and engineering textbooks and handbooks available in the Taylor Library. Book titles and tasks are included in a table in the study. Each student completed four tasks using e-books and four tasks using print books. Half of the participants performed tasks in print books first, and half began with tasks in e-books. Print books were “pre-selected” for each participant. The e-books were all from the same platform: Electronic Book Library. Participants were provided with a laptop computer to access the e-book versions, and a list of questions or facts to locate within each book. Following the methodology of Cotton & Gresty (2006, one researcher prompted students to verbalize actions while performing assigned tasks. A second researcher captured audio and video of the laptop screen as students individually conducted their e-book searches. A third researcher took notes on each session. An exit survey was given to each participant, asking about previous use, knowledge, and attitudes towards e-books. Thematic analysis was then used to examine the collected data.Main Results – Researchers identified four major themes from the data with regard to use of print versus e-books: linear/non-linear strategies; tangible/intangible aspects of books; met/unmet expectations; and transferable/non-transferable behaviours. Researchers found that participants tended to search print books in a linear fashion, whereas they approached e-books non-linearly. Physicality and familiarity with print books helped participants more readily find answers, compared to e-books, where students tried less successfully to mimic techniques used in print books to locate requested information. Participants used indexes in print books, versus e-books where they did not quickly identify the e-books as having them. The students expected that the e-books would behave as other web-based/online sources or search engines would (such as Google books, and commented that they did not. Transferable actions between print and e-books included developing and using keywords for searching.Conclusion – The authors of this study found that student participants did not know how to navigate the e-books presented to them compared with their print counterparts. There was a lack of awareness on the part of participants about e-books in general: the students were unaware that e-books were available through the library catalogue; they did not know that e-books have indexes as print books do; and did not know the differences among platforms offered by the library. All of these facts point to the importance of user education. The authors note the importance of testing of e-book platforms by students, faculty, and librarians prior to committing to purchase particular platforms. The authors note that more research is needed on user interaction with e-books, how e-books are used to assimilate information, and how groups other than undergraduates search e-books.

Treatment and follow-up of patients suffering from the cutaneous radiation syndrome

International Nuclear Information System (INIS)

Peter, R.U.; Gottloeber, P.; Heckmann, M.; Braun-FaIco, O.; Plewig, G.

1996-01-01

The hazards of acute radiation exposure are commonly addressed with respect to total body gamma or neutron irradiation, resulting primarily in bone marrow failure as the main clinically relevant aspect of the acute radiation disease. Under conditions of inhomogeneous exposure, as they are characteristic for many accident scenarios, other organ systems, such as the skin may become more important in determining clinical prognosis. This became especially obvious in the two worst radiation accidents since 1945, the Chernobyl accident in April 1986 and the Goiania accident in September 1987. The characteristic chronic sequelae of accidental cutaneous radiation exposure and therapeutic results have been described based on own clinical experience with treating patients with acute and late cutaneous effects after therapeutic irradiation, and a distinct group of patients having survived the Chernobyl nuclear power plant accident of April 26, 1986. Apart from clinical examination, histological analysis and high-frequency (20 MHz) ultrasound as well as a variety of functional tests have been used to determine the extent of radiation fibrosis and to exclude malignant transformation of keratoses and ulcers. Treatment included, apart from dermatosurgical procedures and plastic surgery for disabling contractures or ulcers, argon laser treatment of telangiectasias, topical tretinoin 0,005% (Epi-Aberel R , Cilag, Frankfurt), etretinate and acitretin (Tigason R , Neotigason R , Hoffmann LaRoche, Grenzach) for radiation keratoses, partly combined with a novel, nonatrophogenic steroid, Mometasonefuroate (Elocon R , Schering-Plough, New Jersey) to antagonize inflammatory reactions, and low-dose interferon-gamma (Polyferon R , Rentschler, Laupheim) for extensive radiation fibrosis. Basic dermatotherapy was performed with an ointment containing linoleic acid (Linola R , Wolff, Bielefeld). With this combination treatment, transepidermal water loss could be sustained, progression of

Interglacial climate dynamics and advanced time series analysis

Science.gov (United States)

Mudelsee, Manfred; Bermejo, Miguel; Köhler, Peter; Lohmann, Gerrit

2013-04-01

Studying the climate dynamics of past interglacials (IGs) helps to better assess the anthropogenically influenced dynamics of the current IG, the Holocene. We select the IG portions from the EPICA Dome C ice core archive, which covers the past 800 ka, to apply methods of statistical time series analysis (Mudelsee 2010). The analysed variables are deuterium/H (indicating temperature) (Jouzel et al. 2007), greenhouse gases (Siegenthaler et al. 2005, Loulergue et al. 2008, L¨ü thi et al. 2008) and a model-co-derived climate radiative forcing (Köhler et al. 2010). We select additionally high-resolution sea-surface-temperature records from the marine sedimentary archive. The first statistical method, persistence time estimation (Mudelsee 2002) lets us infer the 'climate memory' property of IGs. Second, linear regression informs about long-term climate trends during IGs. Third, ramp function regression (Mudelsee 2000) is adapted to look on abrupt climate changes during IGs. We compare the Holocene with previous IGs in terms of these mathematical approaches, interprete results in a climate context, assess uncertainties and the requirements to data from old IGs for yielding results of 'acceptable' accuracy. This work receives financial support from the Deutsche Forschungsgemeinschaft (Project ClimSens within the DFG Research Priority Program INTERDYNAMIK) and the European Commission (Marie Curie Initial Training Network LINC, No. 289447, within the 7th Framework Programme). References Jouzel J, Masson-Delmotte V, Cattani O, Dreyfus G, Falourd S, Hoffmann G, Minster B, Nouet J, Barnola JM, Chappellaz J, Fischer H, Gallet JC, Johnsen S, Leuenberger M, Loulergue L, Luethi D, Oerter H, Parrenin F, Raisbeck G, Raynaud D, Schilt A, Schwander J, Selmo E, Souchez R, Spahni R, Stauffer B, Steffensen JP, Stenni B, Stocker TF, Tison JL, Werner M, Wolff EW (2007) Orbital and millennial Antarctic climate variability over the past 800,000 years. Science 317:793. Köhler P, Bintanja R

Investigating the Microscopic Location of Trace Elements in High-Alpine Glacier Ice

Science.gov (United States)

Avak, Sven Erik; Birrer, Mario; Laurent, Oscar; Guillong, Marcel; Wälle, Markus; Jenk, Theo Manuel; Bartels-Rausch, Thorsten; Schwikowski, Margit; Eichler, Anja

2017-04-01

proxies in glaciers partially affected by melting. References Della Lunga, D., Müller, W., Rasmussen, S. O. & Svensson, A. 2014: Location of cation impurities in NGRIP deep ice revealed by cryo-cell UV-laser-ablation ICPMS, Journal of Glaciology, 60, 970-988. Eichler, A., Schwikowski, M., Gäggeler, H. W. 2001: Meltwater-induced relocation of chemical species in Alpine firn, Tellus B, 53, 192-203. Reinhardt, H., Kriews, M., Miller, H., Schrems, O., Lüdke, C., Hoffmann, E. & Skole, J. 2001: Laser ablation inductively coupled plasma mass spectrometry: a new tool for trace element analysis in ice cores, Fresenius' Journal of Analytical Chemistry, 370, 629-636. Schwikowski, M., Barbante, C., Doering, T., Gäggeler, H. W., Boutron, C., Schotterer, U., Tobler, L., van de Velde, K., Ferrari, C., Cozzi, G., Rosman, K., Cescon, P. 2004: Post-17th-Century Changes of European Lead Emissions Recorded in High-Altitude Alpine Snow and Ice, Environmental Science & Technology, 38, 957-964. Sneed, S. B., Mayewski, P. A., Sayre, W. G., Handley, M. J., Kurbatov, A. V., Taylor, K. C., Bohleber, P., Wagenbach, D., Erhardt, T. & Spaulding, N. E. 2015: New LA-ICP-MS cryocell and calibration technique for sub-millimeter analysis of ice cores, Journal of Glaciology, 61, 233-242.

Development of a New Research Data Infrastructure for Collaboration in Earth Observation and Global Change Science

Science.gov (United States)

Wagner, Wolfgang; Briese, Christian

2017-04-01

processing Petabytes of satellite data. One central site of this infrastructure is the Science Centre Arsenal in Vienna, where a cloud platform and storage system were set up and connected to the Vienna Scientific Cluster (VSC). To provide functionality, this facility connects several hardware components including a Petabyte-scale frontend storage for making data available for scientific analysis and high-performance-computing on the VSC, and robotic tape libraries for mirroring and archiving tens of Petabyte of data. In this contribution, the EODC approach for building a federated IT infrastructure and collaborative data storage and analysis capabilities are presented. REFERENCES Wagner, W. (2015) Big Data infrastructures for processing Sentinel data, in Photogrammetric Week 2015, Dieter Fritsch (Ed.), Wichmann/VDE, Berlin Offenbach, 93-104. Wagner, W., J. Fröhlich, G. Wotawa, R. Stowasser, M. Staudinger, C. Hoffmann, A. Walli, C. Federspiel, M. Aspetsberger, C. Atzberger, C. Briese, C. Notarnicola, M. Zebisch, A. Boresch, M. Enenkel, R. Kidd, A. von Beringe, S. Hasenauer, V. Naeimi, W. Mücke (2014) Addressing grand challenges in earth observation science: The Earth Observation Data Centre for Water Resources Monitoring, ISPRS Commission VII Symposium, Istanbul, Turkey, 29 September-2 October 2014, ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (ISPRS Annals), Volume II-7, 81-88.

Thermodynamics at work - on the limits and potentials of biogeochemical processes

Science.gov (United States)

Peiffer, Stefan

2017-04-01

on the Fe and S side (Peiffer & Wan, 2016; Wan et al, 2014) which will allow for the occurrence of cryptic sulphur cycles, i. e. high turnover of sulphide and sulfate without the appearance of dissolved sulphide species. References Beer, J; Blodau, C (2007): Transport and thermodynamics constrain belowground carbon turover in a northern peatland, Geochim. Cosmochim. Acta, 71, 2989-3002 Blodau, C. (2002). "Carbon cycling in peatlands: A review of processes and controls." Environmental Reviews 10(2): 111-134. Blodau, C; Hoffmann, S; Peine, A; Peiffer, S (1998): Iron and sulfate reduction in the sediments of acid mine lake 116 (Brandenburg, Germany): Rates and geochemical evaluation, Water, Air and Soil Pollution, 108, 249-270 Peiffer, S., Wan M. (2016) Reductive Dissolution and Reactivity of Ferric (Hydr)oxides, in Faivre, D., Iron Oxides: From Nature to Applications, Wiley-VCH, chapter 3, 29-51 Peine, A; Küsel, K; Tritschler, A; Peiffer, S (2000): Electron flow in an iron-rich acidic sedimant - evidence for an acidity-driven iron cycle, Limnol. Oceanogr., 45(5), 1077-1087 Stumm, W.; Morgan, J. J. (1996): Aquatic Chemistry, Wiley Wan, M., Shchukarev, A., Lohmayer, R., Planer-Friedrich, B., Peiffer, S. (2014) Occurrence of surface polysulfides during the interaction between ferric (hydr)oxides and aqueous sulfide. Environmental Science and Technology, 48, 5076-5084

Identification and synchronization of the common cosmic-ray signal in the IntCal13 14C calibration and the Greenland ice-core 10Be records

Science.gov (United States)

Muscheler, Raimund; Adolphi, Florian; Bronk Ramsey, Christopher; Rasmussen, Sune; Hughen, Konrad; Cooper, Alan; Turney, Chris

2017-04-01

core and radiocarbon timescales over the Holocene - Bayesian wiggle-matching of cosmogenic radionuclide records: Clim. Past. , v. 12, p. 15-30. Muscheler, R., Adolphi, F., and Svensson, A., 2014, Challenges in 14C dating towards the limit of the method inferred from anchoring a floating tree ring radiocarbon chronology to ice core records around the Laschamp geomagnetic field minimum: Earth Planet. Sci. Lett., v. 394, p. 209-215. Reimer, P., Bard, E., Bayliss, A., Beck, J. W., Blackwell, P. G., Bronk Ramsey, C., Buck, C. E., Cheng, H., Edwards, R. L., Friedrich, M., Grootes, P., Guilderson, T. P., Haflidison, H., Hajdas, I., Hatté, C., Heaton, T. J., Hoffmann, D. L., Hogg, A. G., Hughen, K. A., Kaiser, K. F., Kromer, B., Manning, S. W., Niu, M., Reimer, R. W., Richards, D. A., Scott, E. M., Southon, J., Staff, R. A., Turney, C. S. M., and van der Plicht, J., 2013, IntCal13 AND Marine13 radiocarbon age calibration curves 0-50,000 years cal BP: Radiocarbon, v. 55, No. 4, p. 1869-1887.

Epidemiological assessment of neglected diseases in children: lymphatic filariasis and soil-transmitted helminthiasis

Directory of Open Access Journals (Sweden)

Ana M. Aguiar-Santos

2013-05-01

intestinal em três amostras de fezes, analisadas pelo método de Hoffmann, Pons e Janer. A investigação filarial foi feita com teste antigênico pela técnica de imunocromatográfica rápida (ICT e pesquisa de microfilárias, utilizando filtração em membrana de policarbonato. Para análise de dados utilizou-se a estatística descritiva através do programa EpiInfo versão 7. Resultados: A prevalência de filariose por ICT foi de 13,8% e por microfilaremia de 1,2%, enquanto a de parasitoses intestinais foi 64,2%. A concomitância do diagnóstico filarial e de parasitoses intestinais foi de 9,4% e, 31,5% eram isentos de ambas as parasitoses. Entre os indivíduos com parasitoses intestinais, 55% eram monoparasitados e 45% poliparasitados. A presença de geohelmintos ocorreu em 72,5% dos parasitados. No grupo com infecção filarial a ocorrência de geohelmintíase foi de 54,5%. Conclusões: O diagnóstico simultâneo de infecção filarial e parasitose intestinal, bem como a elevada frequência de geohelmintos justificam uma reavaliação da estratégia terapêutica do tratamento coletivo no programa de filariose no Brasil. Keywords: Filariasis, Helminthiasis, Neglected diseases, Intestinal parasitic, Prevention and control, Palavras-chave: Filariose linfática, Helmintíase, Doenças negligenciadas, Enteropatias parasitárias, Prevenção e controle

Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial.

Science.gov (United States)

Basset-Seguin, Nicole; Hauschild, Axel; Grob, Jean-Jacques; Kunstfeld, Rainer; Dréno, Brigitte; Mortier, Laurent; Ascierto, Paolo A; Licitra, Lisa; Dutriaux, Caroline; Thomas, Luc; Jouary, Thomas; Meyer, Nicolas; Guillot, Bernard; Dummer, Reinhard; Fife, Kate; Ernst, D Scott; Williams, Sarah; Fittipaldo, Alberto; Xynos, Ioannis; Hansson, Johan

2015-06-01

%) patients; 180 (36%) had adverse events, 70 (14%) had progressive disease, and 51 (10%) requested to stop treatment. Median duration of vismodegib exposure was 36·4 weeks (IQR 17·7-62·0). Adverse events happened in 491 (98%) patients; the most common were muscle spasms (317 [64%]), alopecia (307 [62%]), dysgeusia (269 [54%]), weight loss (162 [33%]), asthenia (141 [28%]), decreased appetite (126 [25%]), ageusia (112 [22%]), diarrhoea (83 [17%]), nausea (80 [16%]), and fatigue (80 [16%]). Most adverse events were grade 1 or 2. We recorded serious adverse events in 108 (22%) of 499 patients. Of the 31 patients who died, 21 were the result of adverse events. As assessed by investigators, 302 (66·7%, 62·1-71·0) of 453 patients with locally advanced basal cell carcinoma had an overall response (153 complete responses and 149 partial responses); 11 (37·9%; 20·7-57·7) of 29 patients with metastatic basal cell carcinoma had an overall response (two complete responses, nine partial responses). This study assessed the use of vismodegib in a setting representative of routine clinical practice for patients with advanced basal cell carcinoma. Our results show that treatment with vismodegib adds a novel therapeutic modality from which patients with advanced basal cell carcinoma can benefit substantially. F Hoffmann-La Roche. Copyright © 2015 Elsevier Ltd. All rights reserved.

Complexity, Metastability and Nonextensivity

Science.gov (United States)

Beck, C.; Benedek, G.; Rapisarda, A.; Tsallis, C.

the glass transition in thermal systems / A. Coniglio ... [et al.] -- Supersymmetry and metastability in disordered systems / I. Giardinu, A. Cavagna and G. Parisi -- The metastable liquid-liquid phase transition: from water to colloids and liquid metals / G. Franzese and H. E. Stanley -- Optimization by thermal cycling / A. Möbius, K. H. Hoffmann and C. Schön -- Ultra-thin magnetic films and the structural glass transition: a modelling analogy / S. A. Cannas ... [et al.] -- Non-extensivity of inhomogeneous magnetic systems / M. S. Reis ... [et al.] -- Multifractal analysis of turbulence and granular flow / T. Arimitsu and N. Arimitsu -- Application of superstatistics to atmospheric turbulence / S. Rizzo and A. Rapisarda -- Complexity of perceptual processes / F. T. Arecchi -- Energetic model of tumor growth / P. Castorina and D. Zappalá -- Active Brownian motion - stochastic dynamics of swarms / W. Ebeling and U. Erdmann -- Complexity in the collective behaviour of humans / T. Vicsek -- Monte Carlo simulations of opinion dynamics / S. Fortunato -- A Merton-like approach to pricing debt based on a non-Gaussian asset model / L. Borland, J. Evnine and B. Pochart -- The subtle nature of market efficiency / J.-P. Bouchaud -- Correlation based hierarchical clustering in financial time series / S. Miccichè, F. Lillo and R. N. Mantegna -- Path integrals and exotic options: methods and numerical results / G. Bormetti ... [et al.] -- Aging of event-event correlation of earthquake aftershocks / S. Abe and N. Suzuki -- Aging in earthquakes model / U. Tirnakli -- The Olami-Feder-Christensen model on a small-world topology / F. Caruso ... [et al.] -- Networks as Renormalized models for emergent behavior in physical systems / M. Paczuski -- Energy landscapes, scale-free networks and Apollonian packings / J. P. K. Doye and C. P. Massen -- Epidemic modeling and complex realities / M. Barthélemy ... [et al.] -- The importance of being central / P. Crucitti and V. Latora.

Next generation solar energy. From fundamentals to applications

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the International Conference between 12th and 14th December, 2011 in Erlangen (Federal Republic of Germany) the following lectures were presented: (1) The opto-electronic physics required to approach the Shockley-Queisser efficiency limit (E. Yablonovitch); (2) The Shockley-Queisser-limit and beyond (G.H. Bauer); (3) Designing composite nanomaterials for photovoltaic devices (B. Rech); (4) Light-Material interactions in energy conversion (H. Atwater); (5) Functional imaging of hybrid nanostructures - Visualizing mechanisms of solar energy utilization (L. Lauhon); (6) Are photosynthetic proteins suitable for PV applications (Y. Rosenwaks); (7) Detailed balance limit in photovoltaic systems (U. Rau); (8) Plasmonics and nanophotonics for next generation photovoltaics (E. Garnett); (9) Dispersion, wave propagation and efficiency analysis of nanowire solar cells (B. Witzigmann); (10) Application of nanostructures to next generation photovoltaics - Opportunities and challenges from an industrial research perspective (L. Tsakalakos); (11) Triplet states in organic and organometallic photovoltaic cells (K.S. Schanze); (12) New photoelectrode architectures (J.T. Hupp); (13) Dendrimers for optoelectronic and photovoltaic applications (P. Ceroni); (14) Photon management with luminescent materials (J. Goldschmidt); (15) Economical aspects of next generation solar cell technologies (W. Hoffmann); (16) Scalability in solar energy conversion - First-row transition metal-based chromophores for dye-sensitized solar cells (J. McCusker); (17) Designing organic materials for photovoltaic devices (A. Harriman); (18) Molecular photovoltaics - What can we learn from model studies (B. Albinsson); (19) Porphyrin-sensitised titanium dioxide solar cells (D. Officer); (20) Light-harvesting: Charge separation, and charge-transportation properties of novel materials for organic photovoltaics (H. Imahori); (21) Phthalocyanines for molecular photovoltaics (T. Torres); (22) Photophysics of

Corn rootworm area-wide management across the United States

International Nuclear Information System (INIS)

Chandler, Laurence D.; Coppedge, James R.; Richard Edwards, C.; Tollefson, Jon J.; Wilde, Gerald E.

2000-01-01

Research Service and cooperating north central United States universities developed a semiochemical insecticide-bait targeted at adult corn rootworms (Sutter and Hesler 1993). The bait, composed of cucurbitacins, a minute amount of carbaryl, and a non-toxic edible carrier, can be applied by conventional aerial or ground sprayers (Hoffmann et al. 1996, Chandler and Sutter 1997, Chandler 1998). The bait adheres to plant surfaces and stimulates rootworm adult feeding, resulting in high levels of mortality and little impact on secondary pests or beneficial arthropods. The bait is applied when females predominate in the field and before significant oviposition begins. By targeting females at this critical developmental stage, egg laying can be reduced and thus, economic larval infestations can be avoided in the following growing season. Unlike soil insecticides, where maize root protection is the primary goal, this control tactic manages rootworm populations. The development of this bait along with improved rootworm monitoring techniques and better understanding of rootworm biology/ecology, forms the basis for the corn rootworm area-wide management programme. Management of rootworm populations using the bait concept is best accomplished when conducted over a large area. Thus, a regional or area-wide approach may effectively reduce rootworm populations, resulting in significant economic savings to growers and improved environmental stewardship through the reduction of insecticide use throughout maize production areas. The information presented discusses the development of the corn rootworm area-wide programme, the initiation of the operational component of the programme, and the results of the first year of semiochemical-bait applications

6th Conference 'Anaerobic treatment of biological wastes'. New tendencies in the biogas technology; 6. Fachtagung Anaerobe biologische Abfallbehandlung. Neue Tendenzen in der Biogastechnologie

Energy Technology Data Exchange (ETDEWEB)

Bilitewski, B.; Werner, P.; Dornack, Christina; Stegmann, R.; Rettenberger, G.; Faulstich, M.; Wittmaier, M. (eds.)

2008-07-01

nitrogen and sulphur as an example (C. Dornack); (17) Biocorrosion due to sulphur and nitrogen - causes and solutions (A. Weger, T. Neddemeyer, M. Mocker); (18) Siloxane in the treatment of biological wastes (S. Mattersteig, L. Brunn, F. Hohmann, B. Bilitewski); (19) Biofuels from biological wastes (A. Schnapke, B. Bilitewski); (20) Fermentative generation of bio hydrogen and bio methane (D. Rechtenbach, M. Meyer, R. Segmann); (21) Possibilities and limits of testing the yield of biogas according to VDI 4630 (T. Fritz, D. Banemann, N. Engler, M. Nelles); (22) Generation of biogas from renewable raw materials in a laboratory biogas plant (S. Wesolowski, E. Ferchau, D. Trimis, N. Ohly); (23) Dry fermentation in the agriculture: Which substrates and technologies are applied (P. Weiland, J. H. von Thuenen); (24) Semi-technical investigations according to the operation at limiting load of a solid reactor used in the fermentation of maize silage (M. Tietze, V. Kuehn, G. Langhans); (25) Industrial-scale experiences in the high-load operation of dry fermenters in the fermentation of renewable raw materials - mono fraction (G. Langhans); (26) Processing and feeding of biogas in Europe - Becomes the idea the trend? (M. Weithaeuser, F. Scholwin); (27) Processing of biogas and power supply to the public grid (M. Harasek, A. Makaruk, M. Miltner); (28) Design for the drying of waste sludge with waste heat from biogas plants for the supply of a cement work (U. Eymann); (29) Comparison of fermentation and combustion of biomass (G. Hoffmann).

Rostock bioenergy forum. Future technologies for bioenergy. Proceedings; 4. Rostocker Bioenergieforum. Zukunftstechnologien fuer Bioenergie. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Within the 4th Rostock bioenergy forum 'future technologies for bioenergy' at 27th and 28th October, 2010, in Rostock (Federal Republic of Germany) the following lectures were held: (1) Sustainable supply of biomass from the agriculture (Christian Gienapp); (2) Biogas plants in conflict of different legal regulation systems (Michael Kern); (3) Logistics of biomass - Do you know the real costs? (Nadine Doden); (4) Potentials of wooden biomass from the landscape conservation using the Lower Saale valley (Sachsen-Anhalt) as an example (Karen Runge); (5) Value creation with energy wood in rural area - Results of a potential study (Marco Hahs); (6) Soil ecological evaluation of short rotational plantations on farmland (Christel Baum); (7) Development of moulds and dry weight losses in bulk wood chips (Christine Idler); (8) Logistics of pellets during the harvest of short-term rotation areas with a field chopper (Franz Handler); (9) Concepts of combustion of biomass within the scope of the BMU funding program 'Energetic utilization of biomass' (Diana Pfeiffer); (10) Thermoelectric transformer for biogenic heat (Karl-Ernst Schnorr); (11) Emissions of benzene in the combustion f gases from wood in cogeneration plants (Christian Hirschmeier); (12) Utilization of additives in the combustion of miscanthus pellets in a small-scale furnace < 100 kW{sub N}WL (Thomas Zeng); (13) Practical experiences with dust separators for small-scale furnaces (Peter Turowski); (14) Analysis for gaining the minimum goal of 10 % renewable energy in traffic sector (Karin Naumann); (15) New diesel components from glycerine (E. Paetzold); (16) Challenges and possibilities in the utilization of biofuels in customary auxiliary heatings (Hajo Hoffmann); (17) Demands on biofuels for the use in combustion engines (Volker Wichmann); (18) Alternative fuel dimethyl ether (Martin Werner); (19) Long-term investigation of the stability of rapeseed fuel and field study of modern Common Rail

The role of the multidisciplinary health care team in the management of patients with Marfan syndrome

Directory of Open Access Journals (Sweden)

von Kodolitsch Y

2016-11-01

Full Text Available Yskert von Kodolitsch,1 Meike Rybczynski,1 Marina Vogler,2 Thomas S Mir,3 Helke Schüler,1 Kerstin Kutsche,4 Georg Rosenberger,4 Christian Detter,5 Alexander M Bernhardt,5 Axel Larena-Avellaneda,6 Tilo Kölbel,6 E Sebastian Debus,6 Malte Schroeder,7,8 Stephan J Linke,9,10 Bettina Fuisting,9 Barbara Napp,1 Anna Lena Kammal,11 Klaus Püschel,11 Peter Bannas,12 Boris A Hoffmann,13 Nele Gessler,13 Eva Vahle-Hinz,14 Bärbel Kahl-Nieke,14 Götz Thomalla,15 Christina Weiler-Normann,16 Gunda Ohm,17 Stefan Neumann,18 Dieter Benninghoven,19 Stefan Blankenberg,1 Reed E Pyeritz20 1Clinic of Cardiology, University Heart Centre, 2Marfan Hilfe Deutschland e.V., Zentrumsehstärke, 3Clinic for Pediatric Cardiology, University Heart Centre, 4Institute of Human Genetics, 5Clinic of Cardiovascular Surgery, University Heart Centre, 6Clinic of Vascular Medicine, University Heart Centre, 7Department of Trauma, Hand, and Reconstructive Surgery, 8Department of Orthopedics, 9Clinic of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 10Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 11Department of Legal Medicine, 12Diagnostic and Interventional Radiology Department and Clinic, 13Clinic of Electrophysiology, University Heart Centre, 14Department of Orthodontics, Center for Dental and Oral Medicine, 15Clinic of Neurology, 16Martin Zeitz Center for Rare Diseases, 17Strategic Business Development, 18Business Unit Quality Management, University Medical Center Hamburg-Eppendorf, 19Mühlenberg-Clinic for Rehabilitation, Bad Malente-Gremsmühlen, 20Zentrumsehstärke, Hamburg, Germany Abstract: Marfan syndrome (MFS is a rare, severe, chronic, life-threatening disease with multiorgan involvement that requires optimal multidisciplinary care to normalize both prognosis and quality of life. In this article, each key team member of all the medical disciplines of a multidisciplinary

Detection of Beta-Emitting Nuclides of Energy >1 Mev in Urine After an Accident by Means of Measurement of the Cerenkov Effect in a Liquid Scintillation Counting System; Detection des Radioelements Emetteurs Beta d'une Energie Superieure a 1 Mev dans l'Urine Apres un Accident, par la Mesure de l'Effet Cerenkov Avec un Ensemble de Comptage a Scintillation Liquide; 041e 0411 041d 0414 ; Deteccion en la Orina de Emisores Beta de Energia Superior a 1 Mev, Despues de un Accidente, por Medicion del Efecto Cerenkov en un Contador de Centelleador Liquido

Energy Technology Data Exchange (ETDEWEB)

Narrog, J. [Landesinstitut fuer Arbeitsschutz und Arbeitsmedizin, Karlsruhe, Federal Republic of Germany (Germany)

1965-06-15

Beta particles of energy >1 MeV in water can be measured by Cerenkov effect in liquid scintillation counters without any further preparation. Since Hoffman reported about this possibility at the Symposium held by the Gesellschaft Deutscher Chemiker (1-2 April 1964) in Karlsruhe-Leopoldshafen, experiments have been carried out in our institute to apply this method to urine. When experiments were carried out with unprepared urine, the measurements were insensitive because of the strong absorption effect. The urine must be cleared. Therefore we tried to oxidate with KMnO{sub 4} and got a clear liquid. The background was very high, because the K of the KMnO{sub 4} contains the radioactive K{sup 40}, which also emits {beta}-rays of energy > 1 MeV (1.32 MeV). We used Na MnO{sub 4} instead of KMnO{sub 4} and got better results. The background is now about 30 counts/min, the lower limit (measured with Sr{sup 90}/Y{sup 90}) about 1 pc/ml urine. If in accidents the content of radioactive K{sup 40} in urine cannot be assessed (e.g. by flame-photometry of the K-content in urine) this method gives the same sensitivity as other methods (e.g. bum and measure in a large-area proportional counting system), in this case (> 2 pc/ml). The measurement with the large-area proportional counter and additional assessment of the K{sup 40} {beta}-activity of the urine is mere sensitive and more accurate. This method is useful for a rapid measurement of large body burdens (and following excretion) of {beta}-nuclides of energy > 1 MeV, demanded by an accidental situation. With these methods we need no more than 90 min total time. (author) [French] On peut mesurer les particules beta d'une energie superieure a 1 MeV grace a l'effet Cerenkov dans des compteurs a scintillation liquide sans aucune autre preparation. Depuis que Hoffmann en a signale la possibilite a un colloque organise par la Gesellschaft Deutscher Chemiker les 1{sup er} et 2 avril 1964 a Karlsruhe-Leopoldshafen, l'auteur a

Introductory Statement to Board of Governors, 2 December 2010, Vienna, Austria

International Nuclear Information System (INIS)

Amano, Y.

2010-01-01

Mr. Chairman, You have before you the Agency's Technical Cooperation Programme for 2011, as recommended by the TACC. Comments provided by Member States on the substance of the Programme and evaluation activities in 2010 will be carefully studied. The greatest emphasis in the TC Programme is on human health, but as usual there are different trends across regions. Member States in Africa, Asia and the Pacific and Europe are showing increasing interest in nuclear power, with related growth in safety and radiation protection projects. Europe and Latin America are also seeing growth in the area of knowledge management and facing the challenges of ageing personnel and infrastructure. We have noted a major improvement in the quality and timeliness of project concepts submitted by Member States, which will facilitate programme implementation. Technical Cooperation/Nuclear Applications During the past twelve months, the Agency has intensified its work on cancer control in developing countries. I am pleased to inform you that our efforts have borne fruit. Contributions to our Programme of Action for Cancer Therapy (PACT) have been running at record levels, exceeding US $5.7 million so far this year. I am very grateful to France, the Republic of Korea, Monaco, New Zealand, Spain, the United States and the OPEC Fund for International Development for their support, as well as to our new private-sector partner Hoffmann-La Roche. Our cooperation with the World Health Organization is going from strength to strength. PACT is widely seen by our Member States as a valuable mechanism to enhance the effectiveness and sustainability of the IAEA's cancer-related activities. We have received a growing number of requests for imPACT review missions and several additional countries have asked to become PACT Model Demonstration Sites. Later this month, we will distribute a journal compiling the expert recommendations from the Scientific Forum on cancer control in developing countries. I will

EDITORIAL: Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010) Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010)

Science.gov (United States)

Reynaerts, Dominiek; Vullers, Ruud

2011-10-01

collaboration with the staff of IOP Publishing. PowerMEMS 2010 contents Harvesting energy from airflow with a michromachined piezoelectric harvester inside a Helmholtz resonator S P Matova, R Elfrink, R J M Vullers and R van Schaijk Analysis and characterization of triangular electrode structures for electrostatic energy harvestingDaniel Hoffmann, Bernd Folkmer and Yiannos Manoli A smart and self-sufficient frequency tunable vibration energy harvesterC Eichhorn, R Tchagsim, N Wilhelm and P Woias Power output enhancement of a vibration-driven electret generator for wireless sensor applicationsTatsuakira Masaki, Kenji Sakurai, Toru Yokoyama, Masayo Ikuta, Hiroshi Sameshima, Masashi Doi, Tomonori Seki and Masatoshi Oba Harvesting traffic-induced vibrations for structural health monitoring of bridgesT V Galchev, J McCullagh, R L Peterson and K Najafi Dispenser-printed planar thick-film thermoelectric energy generatorsA Chen, D Madan, P K Wright and J W Evans Silicon nanowire arrays as thermoelectric material for a power microgeneratorD Dávila, A Tarancón, M Fernández-Regúlez, C Calaza, M Salleras, A San Paulo and L Fonseca A micro thermal switch with a stiffness-enhanced thermal isolation structureTakashiro Tsukamoto, Masayoshi Esashi and Shuji Tanaka A dielectric liquid contact thermal switch with electrowetting actuationA R McLanahan, C D Richards and R F Richards A self-regulating valve for single-phase liquid cooling of microelectronicsRadu Donose, Michaël De Volder, Jan Peirs and Dominiek Reynaerts A MEMS-enabled 3D zinc-air microbattery with improved discharge characteristics based on a multilayer metallic substructureA Armutlulu, Y Fang, S H Kim, C H Ji, S A Bidstrup Allen and M G Allen Design, fabrication and testing of an air-breathing micro direct methanol fuel cell with compound anode flow fieldLuwen Wang, Yufeng Zhang, Youran Zhao, Zijiang An, Zhiping Zhou and Xiaowei Liu A shadow-mask evaporated pyroMEMS igniterD A de Koninck, D Briand and N F de Rooij Aerodynamic

Proceedings of the 2015 WAO Symposium on Food Allergy and the Microbiome

Directory of Open Access Journals (Sweden)

Raúl Lázaro Castro Almarales

2016-10-01

Ross Bell, Chandini Revanna, Constantine Saadeh, Jeff Bennert, Danius Bouyi, Mitsy Veloz, Nelofar Sherali A10 Characteristics of patients with food allergy in health public service Magna Coelho A11 Allergic rhinitis and asthma index increased in Texas panhandle and AHPCO and plasma nanotechnology as solutions Nabarun Ghosh, Jeff Bennert, Danius Bouyi, Constantine Saadeh, Clinton Ross Bell, Mitsy Veloz, Chandini Revanna, Nelofar Sherali A12 Antigen-specific T follicular helper cells mediate peanut allergy in mice Joseph J. Dolence, Takao Kobayashi, Koji Iijima, Hirohito Kita, Hirohito Kita, Ashli Moore, James Krempski A13 Production of recombinant Mal d 3, a major apple allergen, in Pichia Pastoris, to investigate the impact of the food matrix and post-translational modifications on Mal d 3 immuno-reactivity Roberta Aina, Riccardo Asero, Sabine Pfeifer, Pawel Dubiela, Merima Bublin, Christian Radauer, Piotr Humeniuk, Karin Hoffmann-Sommergruber A14 Reaction to sports drink: no whey! Whey allergy in absence of clinical cow’s milk allergy Frank Eidelman, Ves Dimov, Charl Khalil A15 Food allergy on Tumblr: focus on teenage audience may increase educational impact Ves Dimov, Frank Eidelman, Charl Khalil A16 Changes in IgE levels following one-year immunizations in two children with food allergy Alice E. W. Hoyt, Peter Heymann, Alexander Schuyler, Scott Commins, Thomas Platts-Mills A17 IgE and IgG4 antibodies to cow's milk components in children with eosinophilic esophagitis: higher specific IgG4 antibodies and IgG4:IgE ratios compared with subjects with IgE-mediated food allergy Alexander Schuyler, Patrice Kruszewski, John Russo, Lisa Workman, Thomas Platts-Mills, Elizabeth Erwin, Anubha Tripathi A18 Frequency of Sensitization to Food Allergens in Patients with Rhinitis and Asthma in the National Medical Center La Raza “Dr. Antonio Fraga Mouret”, Mexico City Gabriela Yvette Castellanos, Elizabeth Mendieta, Martín Becerril-Angeles

Analyzing the impact of changing size and composition of a crop model ensemble

Science.gov (United States)

Rodríguez, Alfredo

2017-04-01

on IRS features. References Martre, P., Wallach, D., Asseng, S., Ewert, F., Jones, J.W., Rötter, R.P., Boote, K.J., Ruane, A.C., Thorburn, P.J., Cammarano, D., Hatfield, J.L., Rosenzweig, C., Aggarwal, P.K., Angulo, C., Basso, B., Bertuzzi, P., Biernath, C., Brisson, N., Challinor, A.J., Doltra, J., Gayler, S., Goldberg, R., Grant, R.F., Heng, L., Hooker, J., Hunt, L.A., Ingwersen, J., Izaurralde, R.C., Kersebaum, K.C., Muller, C., Kumar, S.N., Nendel, C., O'Leary, G., Olesen, J.E., Osborne, T.M., Palosuo, T., Priesack, E., Ripoche, D., Semenov, M.A., Shcherbak, I., Steduto, P., Stockle, C.O., Stratonovitch, P., Streck, T., Supit, I., Tao, F.L., Travasso, M., Waha, K., White, J.W., Wolf, J., 2015. Multimodel ensembles of wheat growth: many models are better than one. Glob. Change Biol. 21, 911-925. Pirttioja N., Carter T., Fronzek S., Bindi M., Hoffmann H., Palosuo T., Ruiz-Ramos, M., Tao F., Trnka M., Acutis M., Asseng S., Baranowski P., Basso B., Bodin P., Buis S., Cammarano D., Deligios P., Destain M.-F., Doro L., Dumont B., Ewert F., Ferrise R., Francois L., Gaiser T., Hlavinka P., Jacquemin I., Kersebaum K.-C., Kollas C., Krzyszczak J., Lorite I. J., Minet J., Minguez M. I., Montesion M., Moriondo M., Müller C., Nendel C., Öztürk I., Perego A., Rodriguez, A., Ruane A.C., Ruget F., Sanna M., Semenov M., Slawinski C., Stratonovitch P., Supit I., Waha K., Wang E., Wu L., Zhao Z., Rötter R.P, 2015. A crop model ensemble analysis of temperature and precipitation effects on wheat yield across a European transect using impact response surfaces. Clim. Res., 65:87-105, doi:10.3354/cr01322 Wallach, D., Mearns, L.O. Ruane, A.C., Rötter, R.P., Asseng, S. (2016). Lessons from climate modeling on the design and use of ensembles for crop modeling. Climate Change (in press) doi:10.1007/s10584-016-1803-1.

Halogen speciation in volcanic plumes - Development of compact denuder sampling techniques with in-situ derivatization followed by gas chromatography-mass spectrometry and their application at Mt. Etna, Mt. Nyiragongo and Mt. Nyamulagira in 2015.

Science.gov (United States)

Rüdiger, Julian; Bobrowski, Nicole; Hoffmann, Thorsten

2016-04-01

products. The diffusion denuder technique allows sampling of gaseous compounds exclusively without collecting particulate matter. Solvent elution of the derivatized analytes and subsequent analysis with gas chromatography-mass spectrometry gives a limit of detection below 1 ng of bromine. The method was applied in 2015 on volcanic gas plumes at Mt. Etna (Italy), Mt. Nyiragongo and Mt. Nyamulagira (DR Congo) giving reactive bromine mixing ratios from 0.3 ppb (Nyiragongo) up to 22 ppb (Etna, NEC). Compared with total halogen data derived by alkaline trap sampling (Raschig-tube) and ion-chromatography analysis the reactive bromine mixing ratios allow the investigation of the conversion of HBr into reactive species due to plume chemistry with progressing plume age. The new method will be described in detail and the first results on the reactive halogen to total halogen output will be discussed (for bromine and chlorine) and compared to earlier volcanic plume chemistry model studies. References Bobrowski, N. and G. Giuffrida: Bromine monoxide / sulphur dioxide ratios in relation to volcanological observations at Mt. Etna 2006-2009. Solid Earth, 3, 433-445, 2012 Bobrowski, N., R. von Glasow, A. Aiuppa, S. Inguaggiato, I. Louban, O. W. Ibrahim and U. Platt: Reactive halogen chemistry in volcanic plumes. J. Geophys. Res., 112, 2007 Donovan A., V. Tsanev, C. Oppenheimer and M. Edmonds: Reactive halogens (BrO and OClO) detected in the plume of Soufrière Hills Volcano during an eruption hiatus. Geochem. Geophys. Geosyst., 15, 3346-3363, 2014 Rüdiger, J., N. Bobrowski, T. Hoffmann (2015), Development and application of compact denuder sampling techniques with in situ derivatization followed by gas chromatography-mass spectrometry for halogen speciation in volcanic plumes (EGU2015-2392-2), EGU General Assembly 2015

7. Rostock bioenergy forum. Proceedings; 7. Rostocker Bioenergieforum. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

Nelles, Michael (ed.)

2013-10-01

the generation of biofuels (K. Schiemenz); (20) BioBoost - Biomass based energy intermediates boosting bio-fuel production (A. Niebel); (21) Hydrothermal conversion of biomass to liquid energy sources (M. Kroeger); (22) Production of diesel fuels from vegetable oils by means of homogenous catalysed metathesis of methyl oleate (F. Erben); (23) Investigation on application properties of liquid fuels with biogenic compounds (M. Neulen); (24) ENIAK - Development of a non-motor injector coking test facility for alternative fuels (H. Hoffmann); (25) Quality control of mixtures consisting of engine oil and rapeseed oil by means of online oil sensors (K. Thuneke); (26) Plasma regeneration of mineral adsorbents for the precipitation of formaldehyde from exhaust gases of biogas engines (S. Mueller); (27) Economical efficiency of bio energy as the level of prices in the agricultural sector rises (H. Heilmann); (28) Sorghum as an alternative of cultivation to maize (K. Jaekel); (29) New findings on the biogas production from sugar beets (H. Bormann); (30) Losses of the potential in methane formation during the storage of sugar beet pulp in open ground basins (F. Weissbach); (31) Overlapping effects during the fermentation of substrate mixtures (N. Engler); (32) Rising the exploitation of substrates by thermal digestate processing (I. Seick); (33) Application of a qualitative image analysis on the evaluation of microbial process parameters of biogas plants (Y.S. Kim); (34) Practical application of the microbial activity analysis on the monitoring of the process biological stability of biogas plants (L. Neumann); (35) Requirement-specific use of trace element biogas additives under consideration of the bioavailability (A. Feher); (36) Application of the membrane technology on the exhaustive fermentation of renewable raw materials in biogas plants (A. Schreiber); (37) The opportunity of rising efficiency at biogas plants without BHKW (K. Wemken); (38) Quantification of diffuse

Towards better understanding of the response of Sphagnum peatland to increased temperature and reduced precipitation in Central Europe

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Juszczak, Radoslaw; Basińska, Anna; Chojnicki, Bogdan; Gąbka, Maciej; Hoffmann, Mathias; Józefczyk, Damian; Lamentowicz, Mariusz; Leśny, Jacek; Łuców, Dominika; Moni, Christophe; Reczuga, Monika; Samson, Mateusz; Silvennoinen, Hanna; Stróżecki, Marcin; Urbaniak, Marek; Zielińska, Małgorzata; Olejnik, Janusz

2017-04-01

With respect to climate change peatlands are highly vulnerable ecosystems. Especially a potential drying in future might result in a major carbon source and release to the atmosphere. We carried out a field climate manipulation experiment at Rzecin peatland in western Poland to assess how increased temperature and reduced precipitation may impact carbon balance, vegetation, microbes and water chemistry of the Sphagnum peatland. Here, we present results of measurements conducted in two contrasting years (417 mm and 678 mm of precipitation in very dry 2015 and wet 2016, respectively). The experimental design consists of four treatments, each one replicated three times (control, CO; simulated warming, W; prolonged drought, D and warming & drought, W+D). Increased temperatures (T) during the year were achieved by infrared heaters (400W × 4 per site, approx. 60 Wṡm-2 addition of LW radiation). Precipitation was reduced using an automatic curtain, covering the site during nighttime hours of the growth seasons. The manipulation experiment was successful during both years, increasing the air (30 cm height) and soil temperature (5 cm depth, sites W and D) by up to 0.2 oC and 1.0 oC, respectively. Precipitation was reduced to 37 % during both years. At W+D site the peat temperature was nearly two times higher than on W site indicating the impact of drought on T increase. To study the C exchange we developed an automatic mobile platform for measuring CO2/CH4/H2O fluxes (LGR) as well as 13CO2 and 13CH4 fluxes (PICARRO CRDS G2201-i). Measurements were performed, using dynamic ecosystem chambers (for NEE and Reco) and combined with simultaneous measurements of surface spectral properties. Flux calculation and gap filling was done according to Hoffmann et al. 2015. Methane emissions were significantly higher on manipulated plots than on CO (25 gCṡm-2yr-1) during both years, but only in the very dry 2015, CH4 fluxes were the highest on W+D site (33 gC gCṡm-2yr-1). Besides

Photovoltaic solar energy. Proceedings; Photovoltaische Solarenergie. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

Within the 21st symposium 'Photovoltaic Solar Energy' of the Ostbayerisches Technologie-Transfer-Institut e.V. (Regensburg, Federal Republic of Germany) at Banz Monastery (Bad Staffelstein, Federal Republic of Germany) between 8th and 10th March, 2006, the following lessons were held: (1) Basic conditions for a market support programme in the European context (EEG) (Winfried Hoffmann); (2) Actual developments in the German market of photovoltaics (Gerhard Stryi-Hipp); (3) Become a part of the global economic survey of Task 2 ''PV cost over time'' (Thomas Nordmann); (4) The market of photovoltaic will be a European market in the future (Murray Cameron); (5) Development and state of the art of the photovoltaic industry in the Peoples Republic of China (Frank Haugwitz); (6) Silicon for the photovoltaic industry (Karl Hesse); (7) Cell technology: Impulses for a cost effective photovoltaic with valuable silicon (Rolf Brendel); (8) Thin-film solar modules for the photovoltaic - state of the art and industrial perspectives (Michael Powalla); (9) Modules - bottleneck and flood of orders: How to act an installer? (Helmut Godard); (10) Photovoltaic open-field systems - Actual experiences and conflict lines (Ole Langniss); (11) Comparison of actual and future trends of Balance-of-System costs for large scale ground based PV systems with crystalline and thin-film modules (Manfred Baechler); (12) Financing PX projects from a Bank perspective (Joachim Treder); (13) Criteria of quality for solar fonds - Criteria of evaluation for capital investors and self-commitment for emission houses (Ulla Meixner); (14) Analysis of the distribution pathways for photovoltaic plants from the manufacturer to the final customer considering the decreasing demand and increasing prices (Michael Forst); (15) Solar power 2005 - Evaluation of real operational data of 1,000 plants in Germany (Gerd Heilscher); (16) Improvement of PV-inverter efficiency - targets, pathways

Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial.

Science.gov (United States)

Cats, Annemieke; Jansen, Edwin P M; van Grieken, Nicole C T; Sikorska, Karolina; Lind, Pehr; Nordsmark, Marianne; Meershoek-Klein Kranenbarg, Elma; Boot, Henk; Trip, Anouk K; Swellengrebel, H A Maurits; van Laarhoven, Hanneke W M; Putter, Hein; van Sandick, Johanna W; van Berge Henegouwen, Mark I; Hartgrink, Henk H; van Tinteren, Harm; van de Velde, Cornelis J H; Verheij, Marcel

2018-05-01

postoperative chemotherapy (79 [34%] of 233) than during postoperative chemoradiotherapy (11 [4%] of 245). No deaths were observed during postoperative treatment. Postoperative chemoradiotherapy did not improve overall survival compared with postoperative chemotherapy in patients with resectable gastric cancer treated with adequate preoperative chemotherapy and surgery. In view of the poor postoperative patient compliance in both treatment groups, future studies should focus on optimising preoperative treatment strategies. Dutch Cancer Society, Dutch Colorectal Cancer Group, and Hoffmann-La Roche. Copyright © 2018 Elsevier Ltd. All rights reserved.

EDITORIAL: Selected papers from the 22nd MicroMechanics and Microsystems Europe Workshop (MME 2011) Selected papers from the 22nd MicroMechanics and Microsystems Europe Workshop (MME 2011)

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Ohlckers, Per

2012-07-01

three-axis gyroscopes as the most recent 'killer' application. Regardless of application, low cost, high performance and high reliability seem to give us the winning hand leaving competing technology platforms in the dust, for instance in automotive applications. First, I would like to thank the authors of the selected papers for each of their individual excellent contributions. My gratitude also goes to my fellow members in the programme committee (Leon Abelmann, Marin Hill and Martin Hoffmann) for their devotion in the selection of invited speakers and submitted papers, as well as the anonymous JMM reviewers for their careful selection of the final 13 papers included here. Last, but not least, it has been an honour and pleasure for me to collaborate with the editorial staff of Journal of Micromechanics and Microengineering, with the selected best papers presented at MME 2011 included in this special section. This collaboration will continue also for MME 2012, and hopefully also for many future MME workshops. References [1] Morante J R 1997 Preface J. Micromech. Microeng. 7 [2] Evans A G R 1998 Preface J. Micromech. Microeng. 8 [3] Ohlckers P 1999 Introduction J. Micromech. Microeng. 9 [4] Bosseboeuf A 2000 Editorial J. Micromech. Microeng. 10 [5] Hill M 2002 Preface J. Micromech. Microeng. 12 [6] Dascalu D and Muller A 2003 Preface J. Micromech. Microeng. 13 [7] Wolffenbuttel R F 2004 14th Micromechanics Europe Workshop (MME 2003) J. Micromech. Microeng. 14 [8] Puers R 2005 15th European Workshop on Micromechanics (MME 2004) J. Micromech. Microeng. 15 [9] Enoksson P 2006 16th European Workshop on Micromechanics (MME 2005) J. Micromech. Microeng. 16 [10] Morgan H 2007 The 17th European Workshop on Micromechanics (MME 2006) J. Micromech. Microeng. 17 [11] Correia J H 2008 The 18th European Workshop on Micromechanics (MME 2007) J. Micromech. Microeng. 18 060201 [12] Schnakenberg U 2009 The 19th MicroMechanics Europe Workshop (MME 2008) J. Micromech. Microeng. 19 070201

A revision of Metaleptobasis Calvert (Odonata: Coenagrionidae) with seven synonymies and the description of eighteen new species from South America.

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Von Ellenrieder, Natalia

2013-11-25

. Beatty, A. Cordero & J. Hoffmann leg., in FSCA); M. longicauda (Holotype ♂, Brazil, Mato Grosso State, C. Teles Pires, Alto Tapajos, 1-31 viii 1956,  Sick leg., in MNRJ); M. orthogonia (Holotype ♂, Peru, Loreto Dep., San Juan, Río Amazonas, near Iquitos, viii 1939, J. Schunke leg., in FSCA); M. paludicola (Holotype ♂, Peru, Loreto Dep., Tamshiyacu-Tahuayo Reserve, swamp, 4°23'49''S, 73°14'57''W, 27 ii 2009, T. Faasen leg., in RMNH); M. panguanae (Holotype ♂, Peru, Huánuco Dep., Biological Station Panguana, E side Río Yuyapichis, 9°37'S, 74°57'W, 6-17 iv 2003, H.J. & E.-G. Burmeister leg., in ZSM); M. peltata (Holotype ♂, Peru Loreto Dep., Tamshiyacu-Tahuayo Reserve, 4°21'22''S, 73°11'0''W, 19 ii 2010, T. Faasen leg., in RMNH); M. prostrata (Holotype ♂, Peru, Junín Dep., Satipo, v 1945, P. Paprzycki leg., in UMMZ); M. silvicola (Holotype ♂, Peru, Madre de Dios Dep., Explorer's Inn on Río Tambopata, 30 km SW Puerto Maldonado, main trail, 1 viii 1979, M. Perkins & P. Donahue leg., in FSCA); M. spatulata (Holotype ♂, Peru, Huánuco Dep., 10 km N of Cucharas, confluence of Huallaga and Pacay rivers, viii 1954, F. Woytkowski leg., in UMMZ); M. tridentigera (Holotype ♂, Brazil, Rondônia State, Porto Velho, Area Abunan, T11 Aleatorio, 8°46'S, 63°54'W, 86 m, 16 v 2010, Nogueira & Mendes leg., in MZUSP); M. truncata (Holotype ♂, Brazil, Pará State, Jacareacanga, xi 1969, F.R. Barbosa leg., in UMMZ); and M. turbinata (Holotype ♂, Peru, Loreto Dep., Tamshiyacu-Tahuayo Reserve, forest swamp (4°24'18''S, 73°14'38''W), 25 ii 2010, T. Fassen leg., in RMNH). Illustrations, keys, diagnoses, and distribution maps for all 31 currently known species are provided. Phylogenetic relationships within the genus Metaleptobasis are analyzed based on 33 adult morphological characters, including the 31 currently described species of Metaleptobasis and eleven outgroup taxa of other Coenagrionidae of the subfamily Teinobasinae. The cladistic analysis recovered

6th International Symposium on Molecular Allergology (ISMA

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Christiane Hilger

2016-10-01

complex clinical pattern syndrome Inês Mota, Filipe Benito Garcia, Angela Gaspar, Cristina Arêde, Susana Piedade, Graça Sampaio, Graça Pires, Luís Miguel Borrego, Cristina Santa-Marta, Mário Morais-Almeida CC2 IgE sensitization profile in a patient with asteraceae pollen-exotic fruits association Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu CC3 Food-dependent: exercise induced anaphylaxis. Which component to blame? Rosa Anita Rodrigues Fernandes, Isabel Carrapatoso, Raquel Gomes, Celso Pereira, Ana Todo-Bom CC4 Anaphylaxis to intravenous iron preparations in a patient that tolerates oral administration María Cecilia Martín Fernández De Basoa, Javier Barrios Regio, Juan De Castro Cordova, Antón Fernández Ferreiro CC5 IgE sensitization pattern in an adult patient with oral allergy syndrome to peanuts and pollinosis from southern Romania Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu CC6 Evidence of specific IgE to plant-derived cross-reactive carbohydrate determinant in a patient with delayed anaphylaxis to red meat Mariana Vieru, Florin-Dan Popescu, Florin-Adrian Secureanu POSTER PRESENTATIONS Poster Session 1: Molecular allergology and epidemiology P1 Atopic children produce stronger and more frequent IgG responses than non-atopic children: longitudinal data from the German MAS birth cohort Olympia Tsilochristou, Serena Perna, Alina Schwarz, Alexander Rohrbach, Antonio Cappella, Laura Hatzler, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Raffael D’amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi P2 The IgG sensitization profiles against 112 allergenic components support the absence of a protective role of IgG in allergic individuals, outside of the context of SIT Pol André Apoil, Claire Mailhol, Anne Broué-Chabbert, Agnès Juchet, Alain Didier, Elodie Carrer, Thomas Lanot, Antoine Blancher P3 The immune response against the timothy grass pollen allergen Phl p 5 in non

The Phobos Atlas and Geo-portal: geodesy and cartography approach for planetary exploration

Science.gov (United States)

Karachevtseva, Irina; Kozlova, Natalia; Kokhanov, Alexander; Oberst, Jürgen; Zubarev, Anatoliy; Nadezhdina, Irina; Patraty, Vyacheslav; Konopikhin, Anatoliy; Garov, Andrey

-spatial support of future missions to celestial bodies. Our technological solutions are open-source, which makes it possible to increase the functionality of the system, for example, using 3D-modeling. Phobos Geo-portal provides access to results of calculation of the gravity field parameters (Uchaev Dm. et al., 2013); catalog of craters and calculations of surface roughness (Karachevtseva et al., 2012); surface compositional studies based on HRSC color-channel data (Patsyn et al., 2012). Acknowledgments: The Phobos study was supported by RBRF under grant for “Geodesy, cartography and research satellites Phobos and Deimos” (Helmholtz-Russia Joint Research Group), grant agreement No. 11-05-91323. References: Basilevsky A.T., Lorenz C.A., Shingareva T.V., Head J.W., Ramsley K.R., Zubarev A.E. Surface Geology and Geomorphology of Phobos, 2014, Elsevier, Planetary and Space Science, in press. Karachevtseva I. P., Shingareva K. B., Konopikhin A. A., Mukabenova B. V., Nadezhdina I. E., Zubarev A. E., 2012. GIS mapping of Phobos on the results of data processing of remote sensing satellite Mars Express, Modern problems of remote sensing of the Earth from Space. Space Research Institute, Moscow, 304-311 (in Russian). Karachevtseva I.P., Oberst J., Zubarev A.E., Nadezhdina I.E., Kokhanov A.A., Garov A. S. Uchaev D.V., Uchaev Dm.V., Malinnikov V.A., Klimkin N.D. 2014, The Phobos information system. Elsevier, Planetary and Space Science. http://dx.doi.org/10.1016/j.pss.2013.12.015 Kokhanov A.A., Basilevsky A.T., Karachevtseva I.P., Nadezhdina I.E., Zubarev A.E. Depth/Diameter Ratio and Inner Walls Steepness of Large Phobos Craters. The 44th Lunar and Planetary Science Conference, The Woodlands, Texas, USA, March 18-22, 2013. Abstracts [#2289]. Nadezhdina I.E., Zubarev A.E. Create reference coordinate network as a basis for studying the physical parameters of Phobos. 2014, Solar System Research, Moscow, Nauka, in press. Oberst J., Schwarz, G., Behnke, T., Hoffmann, H., Matz, K

Improvement of logistics education from the point of view environmental management

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Bányai, Á.

2009-04-01

cooperation of the higher education institutes and companies of the three counties. This publication was supported by the National Office for Research and Technology within the frame of Pázmány Péter programme. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Office for Research and Technology. Literature: [1] J. Cselényi, Gy. Fischer, J. Murvai, B. Mang: Typical models of the recycling logistics of worn out product. Proceedings of XIV. International Conference on Material Handling and Warehousing in Belgrade, 1996. pp. 138-143. [2] R. Knoth, M. Hoffmann, B. Kopacek, P. Kopacek: A logistic concept to improve the re-usability of electric and electronic equipment, Electronics and the Environment, 2001. Proceedings of the 2001 IEEE International Symposium. 2001. pp. 115 - 118. [3] L. Cser, B. Mang: Cleaner Technologies and Recycling in Hungary. Proceedings of Int. Workshop on Environmental Conscious Manufacturing in Hertogenbosch, The Netherlands, 1997. pp. 48-56.

Glacial recession in the Tropical Andes from the Little Ice Age: the case of Ampato Volcanic Complex (Southern Peru

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Alcalá, J.; Palacios, D.; Zamorano, J. J.

2010-03-01

Europa (Cordillera Cantábrica, NO de España). Análisis morfológico y reconstrucción del avance glaciar histórico. Rev. C & G., 19 (3-4), 79-94. Hastenrath, S. L. (2009): Past glaciation in the tropics. Quaternary Science Reviews, 28: 790-798. Jomelli, V.; Favier, V.; Rabatel, A.; Brunstein, D.; Hoffmann, G.; and Francou, B. (2009): Fluctuations of glaciers in the tropical Andes over the last millennium and palaeoclimatic implications: A review. Palaeogeography, Palaeoclimatology, Palaeoecology, doi: 10.1016/j.palaeo.2008.10.033. Kaser, G., Osmaston, H.A., 2002. Tropical glaciers. Cambridge University Press, Cambridge. Mark, B. (2008): Tracing tropical Andean glaciers over space and time: Some lessons and transdisciplinary implications. Global and Planetary Change, 60: 101-114. Osmaston, H. (2005): Estimates of glacier equilibrium line altitudes by the Area _ Altitude, the Area _ Altitude Balance Ratio and the Area _ Altitude Balance Index Methods and their validation. Quaternary International, 138-139: 22-31. Rabatel, A., Jomelli, V., Naveau, P., Francou, B., Grancher, D. (2005). Dating of Little Ice Age glacier fluctuations in the tropical Andes: Charquini glaciers, Bolivia, 16ºS. C. R. Geoscience, 337: 1311-1322. Rabatel, A., Francou, B., Jomelli, V., Naveau, P., Grancher, D. (2008). A chronology of the Little Ice Age in the tropical Andes of Bolivia (16º S) and its implications for climate reconstruction. Quaternary Research, 70: 198-212. Ramirez, E., Francou, B., Ribstein, P., Descloitres, M., Guerin, R., Mendoza, J., Gallaire, R., Pouyaud, B., Jordan, E., 2001. Small glaciers disappearing in the tropical Andes: a case study in Bolivia: Glaciar Chacaltaya (16°S). Journal of Glaciology 47 (157), 187-194. Soruco, A.; Vincent, C.; Francou, B.; Ribstein, P.; Berger, T.; Sicart, J. E.; Wagnon, P.; Arnaud, Y.; Favier, V.; and Lejeune, Y. (2009): Mass balance of Glacier Zongo, Bolivia, between 1956 and 2006, using glaciological, hydrological and geodetic methods

ОБРАЗ ПЕРЕБЕНДІ ЯК ЮНҐІВСЬКИЙ АРХЕТИП СТАРОГО МУДРЕЦЯ В КОНТЕКСТІ ЄВРОПЕЙСЬКОГО РОМАНТИЗМУ / THE IMAGE OF PEREBENDYA AS AN ARCHETYPE OF THE OLD WISE MAN OF KARL YOUNG IN THE CONTEXT OF EUROPEAN ROMANTICISM

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Ірина КАІЗЕР

2017-11-01

Biographical, comparative (comparison Shevchenko's poetry with literary works of E. Hoffman, A. Mickiewicz, textual and hermeneutic Methods. In the literary-critical reception desk for the first time examines the image of crazy kobzar a Jungian archetype in context folklore and literature sources. This is a scientific novelty of Article. M. Laslo-Kutsyuk research "Perebendya", in contrast to the views of classical Ukrainian literature, which saw an intimate connection with poetry, especially folklore, considering in the context of European Romanticism. Analyzed the poetry of Romanian Scientists believe a bright reflection in St. Petersburg fashion of the time to "turn Hoffmann." The researcher notes that these features are also found in the story "Portrait" from the collection of Gogol "Arabesque", which appeared in 1835. The image kobzar poetry "Perebendya" – an artist, a kind of medium, has the ability emotional impact on the audience, recipients of his sacred function – to be a mediator between God and men. In our opinion, it is important also noted that the image kobzar Perebendya with your own philosophical and artistic load is archetypal. He quite is responsible Jung's archetype of the wise old man, what appears in fairy tales always at a time when the hero is in a hopeless or ambivalent situation, which may get rid of only through thorough considerations alone. Old sage represents, on the one hand, the knowledge – reasoning, wisdom, intelligence, intuition, and the other – moral quality, such as: goodwill, helpness. Conclusions. M. Laslo-Kutsyuk right, considering the character Perebendya on Ukrainian folk soil. But this way operates in folklore as code, archetypal, so it works in writers of romanticism.

PREFACE: Selected papers from the Fourth Annual q-bio Conference on Cellular Information Processing Selected papers from the Fourth Annual q-bio Conference on Cellular Information Processing

Science.gov (United States)

Nemenman, Ilya; Faeder, James R.; Hlavacek, William S.; Jiang, Yi; Wall, Michael E.; Zilman, Anton

2011-10-01

an evaluation of simulation methods for rule-based models. Delmotte et al follow with new methods for analysis of protein interaction dynamics. Finally, Schmidt et al present a novel method for automated experimental design for inference of metabolic networks. Acknowledgments We thank the authors who contributed to this special issue and the over 25 anonymous reviewers of manuscripts, as well as the staff of Physical Biology for their continued support of the q-bio conference. Additionally, we would like to thank the staff of St John's College Conference Services and the staff of the Center for Nonlinear Studies and the Theoretical Biology and Biophysics Group in Los Alamos, especially Adam Shipman, Don Thompson and Ellie Vigil. We also thank the Center for Nonlinear Studies and the Institute for Advanced Studies at Los Alamos National Laboratory, the NIGMS-funded Center for the Spatiotemporal Modeling of Cell Signaling at the University of New Mexico, the New Mexico Consortium, and NIGMS (NIH grant GM082162) for generous financial support. Finally, we thank the advisory and program committee members, who helped the organizers to assemble the program, recruit speakers, review submitted abstracts and publicize the event: Blagoy Blagoev (University of Southern Denmark), Naama Brenner (Technion), Thierry Emonet (Yale University), Alexander Hoffmann (University of California, San Diego), Diane S Lidke (University of New Mexico School of Medicine), Orna Resnekov (Molecular Sciences Institute), Thomas S Shimizu (FOM Institute for Atomic and Molecular Physics), Jin Zhang (Johns Hopkins University), Robert H Austin (Princeton University), Barbara A Baird (Cornell University), Elaine L Bearer (University of New Mexico School of Medicine), Michael E Berens (Translational Genomics Research Institute), Howard C Berg (Harvard University), Hans Frauenfelder (Los Alamos National Laboratory), Byron Goldstein (Los Alamos National Laboratory), Arthur D Lander (University of California

PERSPECTIVE: REDD pilot project scenarios: are costs and benefits altered by spatial scale?

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Carlson, Kimberly M.; Curran, Lisa M.

2009-09-01

deforestation Environ. Res. Lett. 4 034013 Langner A and Siegert F 2009 Spatiotemporal fire occurrence in Borneo over a period of 10 years Glob. Change Biol. 15 48-62 Ramankutty N, Gibbs H K, Achard F, Defries R, Foley J A and Houghton R A 2007 Challenges to estimating carbon emissions from tropical deforestation Glob. Change Biol. 13 51-66 Siegert F, Ruecker G, Hinrichs A and Hoffmann A A 2001 Increased damage from fires in logged forests during droughts caused by El Nino Nature 414 437-40 Soares-Filho B S, Nepstad D C, Curran L M, Cerqueira G C, Garcia R A, Ramos C A, Voll E, Mcdonald A, Lefebvre P and Schlesinger P 2006 Modelling conservation in the Amazon basin Nature 440 520-3 World Bank 2008 State and Trends of the Carbon Market 2008 (Washington, DC: World Bank)

The use of new technologies in Cohort studies

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Carlos Antonio Bruno da Silva

2010-03-01

estudosepidemiológicos: conceitos básicos e aplicaçõesna área do envelhecimento. Epidemiol Serv Saúde.2003;12(3:189-201.10. Muñoz A, Schrager LK, Bacellar H, et al. Trendsin the incidence of outcomes defining acquiredimmunodeficiency syndrome (AIDS in the MulticenterAIDS Cohort Study: 1985-1991. Am J Epidemiol.1993;137:423-38.11. Tager IB. Outcomes in cohort studies. Epidemiol Rev.1998;20(1:15-28.12. Moura KS, Bessa OAACB, Nuto SAS, Sá HLC, VerasFMF, Braga JU. Projeto Coorte dendê: diagnosticodemográfico e condições de moradia de umacomunidade de baixa renda em Fortaleza- Ceará. RevBras Promoção Saúde. 2010;23(1:17-23.13. Preis SR, Massaro JM, Hoffmann U, D’Agostino RBSr, Levy D, Robins SJ, et al. Neck Circumferenceas a Novel Measure of Cardiometabolic Risk: TheFramingham Heart Study. J Clin Endocrinol Metab.2010 May 19. [Epub ahead of print].14. Zomer E, Owen A, Magliano DJ, Liew D, Reid C.Validation of two Framingham cardiovascular riskprediction algorithms in an Australian population: the‘old’ versus the ‘new’ Framingham equation. Eur JCardiovasc Prev Rehabil. 2010 May 13. [Epub aheadof print

Abass Alavi: A giant in Nuclear Medicine turns 80 and is still going strong!

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Høilund-Carlsen, Poul F

2018-01-01

him one of the most cited researchers at the University of Pennsylvania with a production of more than 1,200 articles, a similar number of published abstracts and close to 58,000 citations according to Google Scholar, of which about 20,000 since 2012 when he was 74. This is just part of an amazing story. Having turned to nuclear medicine in 1971, Alavi entered into one of the World's most ingenious and productive medical research en-vironments comprising collaboration of experts in nuclear medicine (David Kuhl) and neurology (Martin Reivich) at Penn, and in physiology and pharmacology (Louis Sokoloff) at the NIH, all of whom contributed significantly to the development of PET. Focus was on cerebral research with beta-emitting 14 C-labeled deoxyglucose for mapping regional cerebral glucose metabolism by means of autoradiography. Alavi became a junior member of this collaboration in which the idea of labeling deoxyglucose with a gamma-emitting isotope arose to allow in vivo examination of the normal and diseased human brain. They contacted Alfred Wolf at Brookhaven National Laboratory who had an interest in synthesizing positron-emitting compounds. He suggested labeling instead with 18 F-FDG and in 1975 Wolf's group including Tatsuo Ido and Joanna Fowler succeeded in synthesizing 18 F-FDG. In the meantime, investigators at Penn had developed high energy collimators for the Mark IV scanner to allow imaging with 18 F-FDG, so in August 1976, two normal volunteers were the first to receive a dose of 18 F-FDG for tomographic brain imaging showing concentration of 18 F-FDG in the gray matter while in one volunteer a "whole-body" scan from the top of the scull to mid-thigh was also obtained. A year before, investigators at Washington University, i.e., Michel Ter-Pogossian in collaboration with Michael Phelps, Edward Hoffmann, and Nizar Mullani had developed what they termed a positron-emission transaxial tomograph for nuclear imaging, i.e. a machine which was the starting

Selected Abstracts of the 11th International Workshop on Neonatology; Cagliari (Italy; October 26-31, 2015

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--- Various Authors

2015-10-01

�� Cagliari (Italy, Matsumoto (Japan, and Leuven (Belgium ABS 52. Congenital remnants as a cause of airway obstruction in newborns • F. Carta, R.A. Caria, C. Gerosa, R. Puxeddu • Cagliari (Italy ABS 53. Involvement of the family in the process of care in pediatric wards perception of nursing and medical staff • L. Cauli, B. Congiu • Cagliari (Italy ABS 54. Investigating the metabolome for monitoring PKU patients under treatment using high resolution nuclear magnetic resonance spectroscopy (NMRS in urine • C. Cannet, F.K. Trefz, J.G. Okun, A. Bayat, H. Schäfer, M. Spraul, G.F. Hoffmann • Heidelberg and Rheinstetten (Germany, and Glostrup (Denmark ABS 55. Administration of surfactant in spontaneously breathing preterm infants: LISA in Verona • C.A. Forcellini, M. Castellani, M. Ventola, G. Giustozzi, F. Bissolo, R. Beghini, E.M. Padovani • Verona (Italy ABS 56. Posterior quadrant dysplasia (PQD and epileptic encephalopathy with onset in the first month of life: presentation of a clinical case • F. Madeddu, S. Cossu, M. Lai, M. Scioni, A. Chabert, D. Pruna • Cagliari (Italy ABS 57. HCMV infection in pregnancy: from classic data towards metabolomics • M. Zavattoni • Pavia (Italy ABS 58. Basic life support training for a Sardinian Scout group • L. Cauli, I. Piras, G. Piras, G. Ragatzu • Cagliari (Italy ABS 59. Developmental trends in preterm children: an integrate model of follow-up in the 1st year of life • G. Papadia, M.R. Morales, G. Perricone, C. Polizzi, A. Faucetta, G. Sulliotti, E. Bellante, B. Giuffrè, F. D’Aleo, R. Mignano Marù • Palermo (Italy ABS 60. Targeted analysis in urine by high resolution nuclear magnetic resonance spectroscopy (NMRS and gas chromatography/mass spectroscopy (GC/MS in the selective screening program for inborn errors of metabolism • C. Cannet, L. Beedgen, F.K. Trefz, J.G. Okun, C.D. Langhans, H. Schäfer, M. Spraul, G.F. Hoffmann • Heidelberg and Rheinstetten (Germany ABS 61. Exploring the role of different

Alarcón-Elbal, P.M. & Lucientes, J. 2012. Actualización del catálogo de Culicoides Latreille, 1809 (Diptera, Ceratopogonidae de España. Graellsia 68:353–362. doi:10.3989/graellsia.2012.v68.064. Bilk, S. Schulze, C. Fischer, M. Beer, M. Hlinak, A. & Hoffmann, B. 2012. Organ distribution of Schmallenberg virus RNA in malformed newborns. Vet. Microbiol. 159:236–238. doi:10.1016/j.vetmic.2012.03.035. De Blas, I., Ruiz-Zarzuela, I. & Vallejo, A. 2006. WinEpi: Working In Epidemiology. An Online Epidemiological Tool. Page in Proceedings of the 11th International Symposium on Veterinary Epidemiology and Economics, Cairns, Australia. Cameron, A.R. & Baldock, F.C. 1998. A new probability formula for surveys to substantiate freedom from disease.. Prev. Vet. Med. 34:1–17. Doceul, V., Lara, E., Sailleau, C., Belbis, G. Richardson, J., Bréard, E., Viarouge, C., Dominguez, M., Hendrikx, P., Calavas, D., Desprat, A., Languille, J., Comtet, L., Pourquier, P., Eléouët, J.-F., Delmas, B., Marianneau, P., Vitour, D. & Zientara, S. 2013. Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe.. Vet. Res. 44:1–13. doi:10.1186/1297-9716-44-31. Elbers, A.R.W., Meiswinkel, R., van Weezep, E., Sloet van Oldruitenborgh-Oosterbaan, M.M. & Engbert, A.K. 2013. Schmallenberg Virus in Culicoides spp. Biting Midges, the Netherlands, 2011. Emerg. Infect. Dis. 19:106–109. doi:10.3201/eid1901.121054. Gariglinany, M.-M., Hoffmann, B., Dive, M., Sartelet, A., Bayrou, C., Cassart, D., Beer, M. & Desmecht, D. 2012. Schmallenberg Virus in Calf Born at Term with Porencephaly, Belgium. Emerg. Infect. Dis. 18. doi:10.3201/eid1806.120104. Greiner, E.C., Mo, C.L., Homan, E.J., Gonzalez, J., Oviedo, M.T., Thompson, L.H. & Gibbs, E.P. 1993. Epidemiology of bluetongue in Central America and the Caribbean: initial entomological findings. Regional Bluetongue Team. Med Vet Entomol 7:309–315. doi:10.1111/j.1365-2915.1993.tb00697.x. Hern

Directory of Open Access Journals (Sweden)

Marlene Villegas-Salas

2017-12-01

Full Text Available Schmallenberg virus affects ruminants, which causes significant economic losses.  The virus is transmitted through vectors of the genus Culicoides; however, other studies do not rule out the possibility of sexual transmission due to its presence in semen. For this reason, the National Service of Animal Health of Costa Rica (SENASA imposed restrictions on the import of semen from animals from the European Union in 2013. Consequently, SENASA conducted a study to determine the presence or absence of antibodies against this virus in bovine, ovine and caprine samples. As a result, no antibodies against this virus were detected in the 748 samples tested. It was concluded that Schmallenberg virus was not circulating in Costa Rican ruminants during the tested period.

PREFACE: Cell-substrate interactions Cell-substrate interactions

Science.gov (United States)

Gardel, Margaret; Schwarz, Ulrich

2010-05-01

cytoskeleton-bound microbeads—the effect of bead-receptor binding dynamics J. Phys.: Condens. Matter 22 194105 [10] Ryzhkov P, Prass M, Gummich M, Kühn J-S, Oettmeier C and Döbereiner H-G 2010 Adhesion patterns in early cell spreading J. Phys.: Condens. Matter 22 194106 [11] Cretel E, Touchard D, Benoliel A M, Bongrand P and Pierres A 2010 Early contacts between T lymphocytes and activating surfaces J. Phys.: Condens. Matter 22 194107 [12] Heil P and Spatz J P 2010 Lateral shear forces applied to cells with single elastic micropillars to influence focal adhesion dynamics J. Phys.: Condens. Matter 22 194108 [13] Kirchenbüchler D, Born S, Kirchgeßner N, Houben S, Hoffmann B and Merkel R 2010 Substrate, focal adhesions, and actin filaments: a mechanical unit with a weak spot for mechanosensitive proteins J. Phys.: Condens. Matter 22 194109 [14] Zemel A, Rehfeldt F, Brown A E X, Discher D E and Safran S A 2010 Cell shape, spreading symmetry, and the polarization of stress-fibers in cells J. Phys.: Condens. Matter 22 194110 [15] Biton Y Y and Safran S A 2010 Theory of the mechanical response of focal adhesions to shear flow J. Phys.: Condens. Matter 22 194111 [16] Sabass B and Schwarz U S 2010 Modeling cytoskeletal flow over adhesion sites: competition between stochastic bond dynamics and intracellular relaxation J. Phys.: Condens. Matter 22 194112 [17] Li Y, Bhimalapuram P and Dinner A R 2010 Model for how retrograde actin flow regulates adhesion traction stresses J. Phys.: Condens. Matter 22 194113 [18] Moshayedi P, da F Costa L, Christ A, Lacour S P, Fawcett J, Guck J and Franze K 2010 Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry J. Phys.: Condens. Matter 22 194114 [19] Lee S, Zeiger A, Maloney J M, Kotecki M, Van Vliet K J and Herman I M 2010 Pericyte contraction at the cell-material interface can modulate the microvascular niche J. Phys.: Condens. Matter 22 194115 [20] Buxboim A, Rajagopal K, Brown A E X and

EDITORIAL: Photonic terahertz technology

Science.gov (United States)

Lisauskas, Alvydas; Löffler, Torsten; Roskos, Hartmut G.

2005-07-01

the state of the art which relies on single-point LT-GaAs photoconductive antennae as THz sources and detectors driven by semiconductor lasers operating at wavelengths around 0.8 m. As laser-induced damage to the sources currently limits the achievable output power, researchers have early-on tried to develop travelling-wave mixers with distributed THz-power generation. Michael describes the status quo of this approach. The replacement of lifetime-limited photoconductive antennae with transit-time-limited p-i-n photomixers can be another way towards higher conversion efficiency if the RC frequency roll-off can be controlled. Döhler et al introduce a novel lumped-element device, a quasi-ballistic cascaded p-i-n photomixer, which promises a significantly better conversion efficiency than standard LT-GaAs photomixers at all frequencies. At laser wavelengths in the telecommunication windows, especially at 1.55 m, where InP-based compound semiconductors exhibit an extremely favourable electron mobility, p-i-n mixers have already established themselves as a powerful THz source. The group of Ito et al have set the standards here and describe their achievements in the fourth paper of this subtopic. The challenge remains to develop a similarly effective optoelectronic detector for these operating wavelengths. This, as Brown et al show in their contribution, turns out to be mainly a materials research issue, and as novel ultrafast materials such as those containing ErAs clusters emerge, so do sensitive detectors and photoconductive sources. The section closes with a paper by Hoffmann et al, which is more speculative in its scope but targets a fascinating goal: THz photomixing directly in a dual-colour semiconductor laser itself, and thus the ultimate miniaturization of a THz source based on photomixing. The third topic is 'THz Laser Technology' and addresses direct laser action at THz frequencies. Hübers et al guide the reader into the topic with a paper presenting the state

PREFACE: Classical density functional theory methods in soft and hard matter Classical density functional theory methods in soft and hard matter

Science.gov (United States)

Haataja, Mikko; Gránásy, László; Löwen, Hartmut

2010-08-01

functional theory versus kinetic theory of simple fluids J. Phys.: Condens. Matter 22 364110 [28] Majaniemi S, Provatas N and Nonomura M 2010 Effective model hierarchies for dynamic and static classical density functional theories J. Phys.: Condens. Matter 22 364111 [29] Warshavsky V B and Song X 2010 Perturbation theory for solid-liquid interfacial free energies J. Phys.: Condens. Matter 22 364112 [30] Rosenfeld Y, Schmidt M, Löwen H and Tarazona P 1997 Phys. Rev. E 55 4245 [31] Roth R, Evans R, Lang A and Kahl G 2002 J. Phys: Condens. Matter 14 12063 [32] Tarazona P, Cuesta J A and Martinez-Raton Y 2008 Density Functional Theories of Hard Particle Systems (Springer Lecture Notes in Physics vol 753) (Berlin: Springer) p 247 [33] Roth R 2010 J. Phys: Condens. Matter 22 063102 [34] Schmidt M, Löwen H, Brader J M and Evans R 2000 Phys. Rev. Lett. 85 1934 [35] Schmidt M, Löwen H, Brader J M and Evans R 2002 J. Phys.: Condens. Matter 14 9353 [36] Hansen-Goos H and Mecke K 2009 Phys. Rev. Lett. 102 018302 [37] Esztermann A, Reich H and Schmidt M 2006 Phys. Rev. E 73 011409 [38] Ramakrishnan T V and Yussouff M 1979 Phys. Rev. B 19 2775 [39] Denton A R and Ashcroft N W 1989 Phys. Rev. A 39 4701 [40] Hasegawa M 1994 J. Phys. Soc. Japan 63 2215 [41] Kol A and Laird B B 1997 Mol. Phys. 90 951 [42] van Teeffelen S, Löwen H and Likos C N 2008 J. Phys.: Condens. Matter 20 404217 [43] van Teeffelen S, Hoffmann N, Likos C N and Löwen H 2006 Europhys. Lett. 75 583 [44] Likos C N, Hoffmann N, Löwen H and Louis A A 2002 J. Phys.: Condens. Matter 14 7681 [45] Curtin W A and Ashcroft N W 1986 Phys. Rev. Lett. 56 2775 [46] Likos C N, Németh Z T and Löwen H 1994 J. Phys.: Condens. Matter 6 10965 [47] Poniewierski A and Holyst R 1988 Phys. Rev. Lett. 61 2461 [48] Graf H and Löwen H 1999 J. Phys.: Condens. Matter 11 1435 [49] Bolhuis P and Frenkel D 1997 J. Chem. Phys. 106 666 [50] Frenkel D, Mulder B M and McTague J P 1984 Phys. Rev. Lett. 52 287 [51] Härtel A and Löwen H 2010 J. Phys

Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neurology and Follow-up"

Directory of Open Access Journals (Sweden)

--- Various Authors

2017-10-01

Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neurology and Follow-up"ABS 1. PRETERM BIRTH AND THE TIMING OF PUBERTY • E. James, C. Wood, H. Nair, T. WilliamsABS 2. NEONATAL PAIN, OPIOID AND ANAESTHETIC EXPOSURE; WHAT REMAINS IN THE HUMAN BRAIN AFTER THE WHEELS OF TIME? • G.E. van den Bosch, D. Tibboel, J.C. de Graaff, H. El Marroun, A. van der Lugt, T. White, M. van DijkABS 3. DEPRESSION DURING PREGNANCY AND DNA METHYLATION CHANGES IN CORD BLOOD • A.-C. Viuff, G. Sharp, D. Raj, K.J. Kyng, L.H. Pedersen, T.B. Henriksen, C.L. ReltonABS 4. PREVENTION OF CEREBRAL PALSY: FEASIBILITY OF UMBILICAL CORD BLOOD STEM CELLS AND UMBILICAL CORD MESENCHYMAL STROMAL CELLS • H. Shintaku, M. Nabetani, T. Hamazaki, S. Kusuda, M. Tamura, S. Watabe, M. Hayakawa, Y. Sato, M. Tsuji, A. Taguchi, H. Ichiba, O. Akira, R. Mori, A.Taki, T. Mukai, T. Nagamura-InoueABS 5. NO GENDER-RELATED DIFFERENCES IN FETAL CORPUS CALLOSUM THICKNESS: IN-UTERO MRI STUDY • R. Bercovitz, R. Achiron, C. Hoffmann, A. AchironABS 6. NEUROMOTOR PROFILE OF HIGH-RISK INFANTS AT TERM OR NEAR TERM • I. Ereno, W.Y. TehABS 7. THE PREDICTIVE VALUE OF SEVERE BRONCHOPULMONARY