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Sample records for ho jules zimmer

  1. Conversations avec Jules Hoüel regards sur la géométrie non euclidienne et l’analyse infinitésimale vers 1875

    CERN Document Server

    Nabonnand, Philippe

    2017-01-01

    Jules Hoüel (1823-1886) a occupé une place particulière dans les mathématiques en France durant la seconde partie du 19ème siècle. Par ses travaux de traduction et ses recensions, il a vivement contribué à la réception de la géométrie non euclidienne de Bolyai et Lobatchevski ainsi qu’aux débats sur les fondements de l’analyse. Il se situe au centre d’un vaste réseau international de correspondances en lien avec son rôle de rédacteur pour le Bulletin des sciences mathématiques et astronomiques. Cet ouvrage contient les correspondances actives et passives de Hoüel avec Joseph-Marie De Tilly, Gaston Darboux et Victor-Amédée Le Besgue ainsi qu’une introduction qui se focalise sur la découverte de l’impossibilité de démontrer le postulat des parallèles d’Euclide et l’apparition des premiers exemples de fonctions continues non dérivables.

  2. Midwest nukes tumble, rock industry: Byron, Marble Hill, Zimmer

    International Nuclear Information System (INIS)

    Nogee, A.

    1984-01-01

    The nuclear industry is suffering from a lack of investor confidence because of cancelled projects and the unprecedented rejection of an operating license for Commonwealth Edison's Byron plant on grounds that the utility failed to meet quality assurance responsibilities. When plans to complete the Zimmer and Marble Hill nuclear plants were abandoned, Bechtel came forward with a financing plan that, while rejected for Zimmer and Marble Hill, could lead to future bailouts. Both Zimmer and Marble Hill plants could be partially converted to coal. The loss of investor confidence in nuclear plants is largely due to political pressures brought on by a combination of citizen intervenors, whistle blowers on construction sites and disagreements between participating utilities. A rise in stock prices followed the cancellation announcements and the lowered investment security ratings

  3. 78 FR 9884 - Approval of Subzone Status; Zimmer Manufacturing BV; Ponce, Puerto Rico

    Science.gov (United States)

    2013-02-12

    ...; Zimmer Manufacturing BV; Ponce, Puerto Rico Pursuant to its authority under the Foreign-Trade Zones Act... subzone at the facility of Zimmer Manufacturing BV located in Ponce, Puerto Rico (FTZ Docket B-81-2012... hereby approves subzone status at the facility of Zimmer Manufacturing BV located in Ponce, Puerto Rico...

  4. Raul Meel ja Ülo Sooster ajakirjas Zimmerli Journal

    Index Scriptorium Estoniae

    2007-01-01

    Ajakirjas Zimmerli Journal, Fall, 2006, lk. 88-103 Jeremy Canwelli artikkel "System, Terminus and Time : The Mystical Art of Raul Meel" ja lk. 118-125 Leonid Lammi mälestused "Ülo Sooster : an Artist, a Friend and his Time"

  5. Jules Horowitz Reactor, basic design

    International Nuclear Information System (INIS)

    Bergamaschi, Y.; Bouilloux, Y.; Chantoin, P.; Guigon, B.; Bravo, X.; Germain, C.; Rommens, M.; Tremodeux, P.

    2003-01-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it. It has the ambition to provide the necessary nuclear data and maintain a fission research capacity in Europe after 2010. This capacity should be service-oriented. It will be established in Cadarache. The Jules Horowitz reactor will also: - represent a significant step in term of performances and experimental capabilities, - be designed with a high flexibility, in order to satisfy the current demand from European industry, research and be able to accommodate future requirements, - reach a high level of safety, according to the best current practice. This paper will present the main functionalities and the design options resulting from the 'preliminary design' studies. (authors)

  6. Jules Horowitz reactor, basic design

    International Nuclear Information System (INIS)

    Bergamaschi, Y.; Bouilloux, Y.; Chantoin, P.; Guigon, B.; Bravo, X.; Germain, C.; Rommens, M.; Tremodeux, P.

    2002-01-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it. It has the ambition to provide the necessary nuclear data and maintain a fission research capacity in Europe after 2010. This capacity should be service-oriented. It will be established in Cadarache. The Jules Horowitz reactor will also: represent a significant step in term of performances and experimental capabilities; be designed with a high flexibility, in order to satisfy the current demand from European industry, research and be able to accommodate future requirements; reach a high level of safety, according to the best current practice. This paper will present the main functionalities and the design options resulting from the 'preliminary design' studies. (author)

  7. Jules Verne's Metaphor of the Iron Cage

    NARCIS (Netherlands)

    Ossewaarde, Marinus R.R.

    2010-01-01

    Max Weber's concept of the iron cage has become a byword in the scholarly world since the publication in 1930 of Talcott Parsons’ translation of The Protestant Ethic and the Spirit of Capitalism. What is less well-known is that Jules Verne had earlier used the iron cage metaphor in Twenty Thousand

  8. Jules Stein, MD: Ophthalmologist, Entertainment Magnate, and Advocate for Vision.

    Science.gov (United States)

    Straatsma, Bradley R; Weeks, David F

    2016-04-01

    To report the lifetime activities and accomplishments of Jules Stein, MD. Retrospective review. Assessment of published and unpublished biographical material. Jules Stein combined his love of music and medicine with organizational skills to achieve successive careers as a musician, an ophthalmologist, an entertainment magnate, and an advocate for vision. To preserve vision, he founded Research to Prevent Blindness, founded the Jules Stein Eye Institute at the University of California, Los Angeles, and led a multiyear campaign to establish the National Eye Institute. With successive careers and extraordinary achievements, Jules Stein created an enduring legacy of benefits to ophthalmology, vision research, and the prevention of blindness. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  9. The Wm. H. Zimmer Nuclear Power Station: Draft environmental statement (Docket No. 50-358)

    International Nuclear Information System (INIS)

    1976-10-01

    The proposed action is the issuance of an operating license to the Cincinnati Gas and Electric Company, the Columbus and Southern Ohio Electric Company, and the Dayton Power and Light Company for the startup and operation of the Wm. H. Zimmer Nuclear Power Station (Docket No. 50-358) (the station), located on the Ohio River in Clermont County, about 24 miles southeast of Cincinnati, Ohio. The information in this statement represents the second assessment of the environmental impact associated with the Zimmer Nuclear Power Station pursuant to the guidelines of the National Environmental Policy Act of 1969 (NEPA) and 10 CFR Part 51 of the Commission's Regulations. After receipt of an application in 1970 to construct this plant, the staff carried out a review of impact that would occur during the plant's construction and operation. This evaluation was issued as a final environmental statement in September 1972. As the result of this environmental review, a safety review, an evaluation by the Advisory Committee on Reactor Safeguards, and a public hearing in Cincinnati, Ohio, the AEC (now NRC) issued a permit in October 1972 for the construction of Unit 1 of the Zimmer Nuclear Power Station. As of June 1976, the construction of the plant was 54% complete. With a proposed fuel-loading data of April 1978, the applicant has petitioned for license to operate Unit 1 and has submitted (September 1975) the required safety and environmental reports to substantiate this petition. 96 refs., 17 figs., 34 tabs

  10. Jules Horowitz reactor (RJH): its design

    International Nuclear Information System (INIS)

    Dupuy, J.P.

    2002-01-01

    This article presents the design of the new irradiation facility (Jules Horowitz reactor) that is planned to be built on the Cadarache site of Cea. 2 principles have been followed. The first one is based on a physical separation between the systems and activities related to the reactor and the experiments from one hand and the other systems and means dedicated to the treatment of the experimental devices before and after irradiation on the other hand. This first principle implies to build 2 buildings: the reactor building and the nuclear auxiliaries building. Inside the reactor building activities from the reactor itself are separated from those dedicated to experimentation. In order to maximize the efficiency of such a reactor, an important number of simultaneous experiments is expected, which will generate an endless flux of incoming and out-going experiments and as a consequence an important handling work between the different work posts. The second principle aims at easing any handling work without breaking the rules of confinement. The different storing pools, the water pits that lead to the 5 hot cells and the reactor tank will communicate through a water-filled canal that will link the 2 buildings. (A.C.)

  11. Sharp and the Jules Verne Launcher

    Science.gov (United States)

    Hunter, John; Cartland, Harry

    1996-03-01

    Lawrence Livermore National Laboratory (LLNL) has built the worlds largest hydrogen gas gun called SHARP, (Super High Altitude Research Project). Originally designed to launch 5 kg to a 450 km altitude, SHARP is configured horizontally at Site 300 in Tracy, California. SHARP is successfully delivering 5 kg scramjets at Mach 9 in aerophysics tests. Some of the results of the scramjet tests are enlightening and are presented insofar as they are relevant to future launches into space. Using a light gas gun to launch payloads into orbit has been analyzed. We look at LEO (Low Earth Orbit), GEO (Geosynchronous Earth Orbit), and LO (Lunar Orbit). We present a conceptual design for a large light gas gun called the Jules Verne Launcher (JVL). The JVL can deliver 3.3 metric tons to a 500 km low earth orbit. We anticipate one launch per day. We present the history of light gas guns, the SHARP design and performance, and the JVL design. Another section is devoted to the vehicle environment and resultant design. Lastly, we present a cost analysis. Our results indicated that the JVL will be able to deliver 1000 metric tons of payload to LEO yearly. The cost will be 5% of the best US rocket delivery cost. This technology will enable the next phase of man's exploration of space.

  12. In Memoriam: Jules Aarons (1921-2008): Space Weather Pioneer

    Science.gov (United States)

    Mendillo, Michael

    2009-05-01

    Prior to the use of the phrase “space weather” to summarize all possible effects of solar-terrestrial physics upon technological systems, the U.S. Department of Defense (DOD) created and maintained active programs in the application aspects of space physics. The person arguably most associated with those efforts was Jules Aarons, who died on 21 November 2008 at age 87 at his home in Newton, Mass. Jules was a research professor of astronomy and space physics at Boston University from 1981 to 2005, but it was as a civilian scientist at the Air Force Cambridge Research Laboratory (AFCRL) from 1946 to 1981 that Jules emerged as a true leader in studies of how the ionosphere can affect radio communications. He specialized in scintillations, those serious fluctuations of radio signal amplitudes and phases that cause dropouts in otherwise reliable communications links.

  13. The 'Reacteur Jules Horowitz': The preliminary design

    International Nuclear Information System (INIS)

    Ballagny, A.; Frachet, S.; Minguet, J.L.; Leydier, C.

    1999-01-01

    The 'Reactor Jules Horowitz' is a new research reactor project dedicated to materials and nuclear fuels testing, the location of which is foreseen at the CEA-Cadarache site, and the start-up in 2008. The launching of this project arises from a double finding: 1) the development of nuclear power plants aimed at satisfying the energy needs of the next century cannot be envisaged without the disposal of experimental reactors which are unrivalled for the validation of new concepts of nuclear fuels, materials, and components as well as for their qualification under irradiation. 2) the present park of experimental reactors is 30 to 40 years old and it is advisable to examine henceforth the necessity and the nature of a new reactor to take over and replace, at the beginning of next century, the reactors shut-down in the mean time or at the very end of their lives. Within this framework, the CEA has undertaken, in the last years, a reflection on the mid and long term irradiations needs, to determine the main features and performances of this new reactor. The concept of the reactor will have to fulfil the thermal neutron irradiation requirements as well as the fast neutron experimental needs, with a great potential versatility for any new irradiation programs. The selected reactor project, among several different concepts, is finally a light water open pool concept, with 100 MW thermal power. It could reach neutronic fluxes twice those of present French reactors, and allows many irradiations in the core and around the core, under high neutron fluxes. The reactor will satisfy the highest level of safety in full accordance with international safety recommendations and French safety approach for this kind of nuclear facility, thus giving an added safety margin keeping in mind the versatility of research reactors. The feasibility studies have been focused on the main items, and have permit to determine: the core and fuel designs, with added pressurisation; the different core

  14. Alfred Jules Aver's induction and Marxian historical evolution: It's ...

    African Journals Online (AJOL)

    Alfred Jules Aver's induction and Marxian historical evolution: It's lessons for the current economic global crisis. ... Economic liberalism, political manipulation and gross capitalism have been given as the major causes of the present situation in the world economy. It is on this touchstone that we tried to examine the Marxian ...

  15. 77 FR 68102 - Foreign-Trade Zone 163-Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR

    Science.gov (United States)

    2012-11-15

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-81-2012] Foreign-Trade Zone 163--Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR An application has been submitted to the Foreign-Trade Zones Board (the Board) by CODEZOL, C.D., grantee of FTZ 163, requesting special- purpose subzone...

  16. Would Jule Charney Have Cracked the Madden-Julian Oscillation?

    Science.gov (United States)

    Emanuel, K.

    2017-12-01

    Jule Charney's approach to science often involved looking at old problems in new ways. One example was his theory of baroclinic instability, which followed on the heels of long-standing efforts to explain well-observed cyclones and anticyclones. He mastered the art of boiling a physical phenomenon down to its essence, throwing away many things that others had considered important while expressing that which he retained in the simplest possible way. To help honor Charney's legacy, I will review the history of another well-observed phenomenon - the Madden Julian Oscillation (MJO) - together with the many largely unsuccessful efforts to explain it, culminating finally in a satisfying explanation that Jule would have loved.

  17. The launching of the construction of the Jules Horowitz Reactor

    International Nuclear Information System (INIS)

    Anon.

    2007-01-01

    In March 2007 the French deputy minister of industry has officially launched the construction of the new research reactor called Jules Horowitz (RJH) on the Cea site of Cadarache. RJH, that is due to operate in 2014, will be used to study the aging process of irradiated materials in any type of reactors, the behaviour of new nuclear fuels irradiated in different configurations and scenarios, and to produce radionuclides for nuclear medicine and high-quality doped silicon for the electronics industry. The investment that reaches 500 million euros is dispatched between Cea (50%), EDF (20%), Areva (10%) and foreign contributors (20%). (A.C.)

  18. The work of Jules Horowitz. The great Cea actors

    International Nuclear Information System (INIS)

    Arnaudet, L.; Deloche, R.; Procope, L.

    1999-01-01

    Jules Horowitz contributed to the heart calculation of the first french reactor Zoe. He developed the first experimental reactors, invested himself in the reactors physics and helped with EDF to the realisation of the French electronuclear programme. His work is marked out the building of great research devices: The Laue-Langevin Institute (ILL), The European Source of Synchrotron radiation (ESRF), the great national heavy ions accelerator (GANIL) the superconductor tokamak TORE SUPRA) the Leon Brillouin Laboratory (LLB), the Frederic Joliot hospital service (SHFJ). (N.C.)

  19. De Jules et Jim au Vel’ d’Hiv

    Directory of Open Access Journals (Sweden)

    Annie Oliver

    2012-12-01

    Full Text Available Dans son roman intitulé On ne peut plus dormir tranquille quand on a une fois ouvert les yeux, Robert Bober s’inspire de sa propre histoire et relate bon nombre de faits qui ont réellement eu lieu, à commencer par le tournage en 1961 du film de François Truffaut Jules et Jim. C’est à partir de ce film – et de nombreuses autres références cinématographiques, de Max Ophuls aux Marx Brothers – que le narrateur, d’origine juive polonaise, va retrouver l’histoire de sa famille mais aussi celle d’une ville, Paris, de la Commune de 1871 à la rafle du Vélodrome d’Hiver en 1942.In his novel On ne peut plus dormir tranquille quand on a une fois ouvert les yeux Robert Bober draws his inspiration from his own life and tells a good number of events which have really taken place. Starting with the shooting, in 1961, of François Truffaut Jules et Jim. From this movie, as well as from many other film references – from Max Ophuls to the Marx Brothers – the narrator of Jewish-Polish origin rediscovers the history of his own family together with that of Paris, from the 1971 Commune to the 1942 round-up of Jews in the Vélodrome d’Hiver.

  20. Evaluation of JULES-crop performance against site observations of irrigated maize from Mead, Nebraska

    OpenAIRE

    Williams, Karina; Gornall, Jemma; Harper, Anna; Wiltshire, Andy; Hemming, Debbie; Quaife, Tristan; Arkebauer, Tim; Scoby, David

    2016-01-01

    The JULES-crop model (Osborne et al., 2015) is a parameterisation of crops within the Joint UK Land Environment Simulator (JULES), which aims to simulate both the impact of weather and climate on crop productivity and the impact of crop-lands on weather and climate. In this evaluation paper, observations of maize at three FLUXNET sites in Nebraska (US-Ne1, US-Ne2, US-Ne3) are used to test model assumptions and make appropriate input parameter choices. JULES runs are performed for the irrigate...

  1. In Jules Verne's Footsteps: Seismology in the source

    Science.gov (United States)

    Ellsworth, Bill; Ito, Hisao; Malin, Peter; Abercrombie, Rachel

    When Professor Otto Lidenbrock led his little band to the center of the Earth in Jules Verne's 1864 classic novel, the intrepid adventurers needed little more than practical 19th century clothes to provide them with comfort and protection. How different the science of earthquakes would be if conditions in the Earth were really so friendly to the would-be observer. Even the operation of seismic sensors at the relatively modest depth of 2-3 km, roughly the depth of the shallowest crustal earthquakes, requires careful precautions against the effects of unstable materials, temperature, pressure, and water for successful long-term observations to be made. Indeed, the handful of successful deep borehole experiments that have been conducted to date have depended on simple sensors with limited bandwidth and dynamic range, and have yielded data that were not ideally suited to investigating the details of the earthquake source.

  2. [Scientific contributions of Jules Hirsch regarding the physiopathogenesis of obesity].

    Science.gov (United States)

    Zárate, Arturo; Manuel, Leticia

    2016-01-01

    Jules Hirsch was born in New York City and died at age 88 after a long illness. He was considered notorious leader in the study of human metabolism mainly in the area of lipids and obesity. His research at The Rockefeller University helps establish the mechanism of obesity and lipids metabolism. Hirsch joined Rockefeller´s faculty in 1954 and remained there for the rest of his career. Hirsch´s research helped to support the idea of dynamic interactions among diet, physical activity, general metabolism and obesity. At that time most scientific considered adipose tissue to be biologically inert such as a passive insulator in which the body reserved energy in the form of triglycerides. Hirsch had a natural characteristic of showing a nice smile and greeting for everyone he worked with at the university. Another important contribution was there relationship between diet and cardiovascular ailments as well as metabolism disturbance.

  3. A new MTR fuel for a new MTR reactor: UMo for the Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Guigon, B.; Vacelet, H.; Dornbusch, D.

    2000-01-01

    Within some years, the Jules Horowitz Reactor will be the only working experimental reactor (material and fuel testing reactor) in France. It will have to provide facilities for a wide range of needs from activation analysis to power reactor fuel qualification. In this paper the main characteristics of the Jules Horowitz Reactor are presented. Safety criteria are explained. Finally, merits and disadvantages of UMo compared to the standard U 3 Si 2 fuel are discussed. (author)

  4. A cognitive movement scientist's view on the link between thought and action: insights from the "Badische Zimmer" metaphor.

    Science.gov (United States)

    Hossner, Ernst-Joachim

    2009-01-01

    The problem of a bidirectional link between thought and action is approached from the perspective of cognitive movement science. The metaphor of the "Badische Zimmer" - an adaptation of Searle's Chinese room metaphor - is used to illustrate shortcomings in the classical conception of linear information processing and to introduce some features which current theories of movement control and learning should embrace. On this basis, the case is made for a return to an ideomotor view of motor control and learning based on effect prediction (E') as a function of the situational context (S') and one's own motor responses (R'). The relevance of the derived concept of sensorimotor chains linking elementary S'R'E' units in the course of motor learning is finally discussed with respect to potential implications for an integrative theory of perception, action, and decision making.

  5. A new MTR fuel for a new MTR reactor: UMo for the Jules Horowitz reactor

    Energy Technology Data Exchange (ETDEWEB)

    Guigon, B. [CEA Cadarache, Dir. de l' Energie Nucleaire DEN, Reacteur Jules Horowitz, 13 - Saint-Paul-lez-Durance (France); Vacelet, H. [Compagnie pour l' Etude et la Realisation de Combustibles Atomiques, CERCA, Etablissement de Romans, 26 (France); Dornbusch, D. [Technicatome, Service d' Architecture Generale, 13 - Aix-en-Provence (France)

    2003-07-01

    Within some years, the Jules Horowitz Reactor will be the only working experimental reactor (material and fuel testing reactor) in France. It will have to provide facilities for a wide range of needs: from activation analysis to power reactor fuel qualification. In this paper will be presented the main characteristics of the Jules Horowitz Reactor: its total power, neutron flux, fuel element... Safety criteria will be explained. Finally merits and disadvantages of UMo compared to the standard U{sub 3}Si{sub 2} fuel will be discussed. (authors)

  6. Quantifying the Impact of Tropospheric Ozone on Crops Productivity at regional scale using JULES-crop

    Science.gov (United States)

    Leung, F.

    2016-12-01

    Tropospheric ozone (O3) is the third most important anthropogenic greenhouse gas. It is causing significant crop production losses. Currently, O3 concentrations are projected to increase globally, which could have a significant impact on food security. The Joint UK Land Environment Simulator modified to include crops (JULES-crop) is used here to quantify the impacts of tropospheric O3 on crop production at the regional scale until 2100. We evaluate JULES-crop against the Soybean Free-Air-Concentration-Enrichment (SoyFACE) experiment in Illinois, USA. Experimental data from SoyFACE and various literature sources is used to calibrate the parameters for soybean and ozone damage parameters in soybean in JULES-crop. The calibrated model is then applied for a transient factorial set of JULES-crop simulations over 1960-2005. Simulated yield changes are attributed to individual environmental drivers, CO2, O3 and climate change, across regions and for different crops. A mixed scenario of RCP 2.6 and RCP 8.5 climatology and ozone are simulated to explore the implication of policy. The overall findings are that regions with high ozone concentration such as China and India suffer the most from ozone damage, soybean is more sensitive to O3 than other crops. JULES-crop predicts CO2 fertilisation would increase the productivity of vegetation. This effect, however, is masked by the negative impacts of tropospheric O3. Using data from FAO and JULES-crop estimated that ozone damage cost around 55.4 Billion USD per year on soybean. Irrigation improves the simulation of rice only, and it increases the relative ozone damage because drought can reduce the ozone from entering the plant stomata. RCP 8.5 scenario results in a high yield for all crops mainly due to the CO2 fertilisation effect. Mixed climate scenarios simulations suggest that RCP 8.5 CO2 concentration and RCP 2.6 O3 concentration result in the highest yield. Further works such as more crop FACE-O3 experiments and more Crop

  7. Production development and utilization of Zimmer Station wet FGD by-products. Final report. Volume 1, Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Kevin [Dravo Technology Center, Pittsburgh, PA (United States); Beeghly, Joel H. [Dravo Technology Center, Pittsburgh, PA (United States)

    2000-11-30

    About 30 electric utility units with a combined total of 15,000 MW utilize magnesium enhanced lime flue gas desulfurization (FGD) systems. A disadvantage of this and other inhibited or natural oxidation wet FGD systems is the capital and operating cost associated with landfill disposal of the calcium sulfite based solids. Fixation to stabilize the solids for compaction in a landfill also consumes fly ash that otherwise may be marketable. This Executive Summary describes efforts to dewater the magnesium hydroxide and gypsum slurries and then process the solids into a more user friendly and higher value form. To eliminate the cost of solids disposal in its first generation Thiosorbic® system, the Dravo Lime Company developed the ThioClear® process that utilizes a magnesium based absorber liquor to remove S02 with minimal suspended solids. Magnesium enhanced lime is added to an oxidized bleed stream of thickener overflow (TOF) to produce magnesium hydroxide [Mg(OH)2] and gypsum (CaS04 • 2H20), as by-products. This process was demonstrated at the 3 to 5 MW closed loop FGD system pilot plant at the Miami Fort Station of Cinergy, near Cincinnati, Ohio with the help of OCDO Grant Agreement CDO/D-91-6. A similar process strictly for'recovery and reuse of Mg(OH)2 began operation at the Zimmer Station of Cinergy in late 1994 that can produce 900 pounds of Mg(OH)2 per hour and 2,600 pounds of gypsum per hour. This by-product plant, called the Zimmer Slipstream Magnesium Hydroxide Recovery Project Demonstration, was conducted with the help of OCDO Grant Agreement CDO/D-921-004. Full scale ThioClear® plants began operating in 1997 at the 130 MW Applied Energy Services plant, in Monaca, PA, and in year 2000 at the 1,330 MW Allegheny Energy Pleasants Station at St. Marys, WV.

  8. The 'Reacteur Jules Horowitz': a new experimental reactor project

    International Nuclear Information System (INIS)

    Frachet, S.; Ballagny, A.

    1999-01-01

    The Jules Horowitz Reactor (RJH) is a new research reactor project dedicated to materials and nuclear fuel testing, the location of which is foreseen at the CEA-CADARACHE site, and the start-up in 2006. The launching of this project originated from a double finding: The development of nuclear power plants aimed at satisfying the energy needs of the next century, cannot be envisaged without experimental reactors which are unrivaled for the validation of new concepts of nuclear fuels, materials, and components as well as for their qualification under irradiation. The existing experimental reactors are 30 to 40 years old and it is advisable to examine henceforth the necessity for and the nature of a new reactor to take over and replace, at the beginning of next century, the reactors shut-down in the mean time or at the very end of their lives. Within this framework, the CEA has undertaken, in the last years, a study on the mid and long term irradiation needs, to determine the main features and performances of this new reactor. The concept of the reactor will have to fulfill the thermal neutron irradiation requirements as well as the fast neutron experimental needs, with a great potential versatility for any new irradiation programs. The reactor project selected among several different concepts, is finally a light water pool concept, with 100 MW thermal power. It could reach neutronic fluxes twice those of present French reactors, and allows for many irradiations in and around the core, under high neutron fluxes. The reactor will satisfy the highest level of safety in full accordance with international safety recommendations and the French safety approach for this kind of nuclear facility, thus giving an added safety margin keeping in mind the versatility of research reactors. The feasibility studies have been focused on the following most important items: neutronic and thermalhydraulic studies on alternative core designs, with or without added pressurization

  9. Reactor. Mind picture of the future Jules-Horowitz Reactor (RHJ)

    International Nuclear Information System (INIS)

    Eustache, S.

    1999-01-01

    This paper gives information about the future research reactor, named Reactor Jules-Horowitz (RJH). This irradiation reactor will be placed at industrialists disposal, for research concerning the competitiveness and the safety french electro-nuclear park. Principles and innovations are detailed. This reactor will respect the ALARA principle (as low as reasonably achievable). (A.L.B.)

  10. Multi-site evaluation of the JULES land surface model using global and local data

    Directory of Open Access Journals (Sweden)

    D. Slevin

    2015-02-01

    Full Text Available This study evaluates the ability of the JULES land surface model (LSM to simulate photosynthesis using local and global data sets at 12 FLUXNET sites. Model parameters include site-specific (local values for each flux tower site and the default parameters used in the Hadley Centre Global Environmental Model (HadGEM climate model. Firstly, gross primary productivity (GPP estimates from driving JULES with data derived from local site measurements were compared to observations from the FLUXNET network. When using local data, the model is biased with total annual GPP underestimated by 16% across all sites compared to observations. Secondly, GPP estimates from driving JULES with data derived from global parameter and atmospheric reanalysis (on scales of 100 km or so were compared to FLUXNET observations. It was found that model performance decreases further, with total annual GPP underestimated by 30% across all sites compared to observations. When JULES was driven using local parameters and global meteorological data, it was shown that global data could be used in place of FLUXNET data with a 7% reduction in total annual simulated GPP. Thirdly, the global meteorological data sets, WFDEI and PRINCETON, were compared to local data to find that the WFDEI data set more closely matches the local meteorological measurements (FLUXNET. Finally, the JULES phenology model was tested by comparing results from simulations using the default phenology model to those forced with the remote sensing product MODIS leaf area index (LAI. Forcing the model with daily satellite LAI results in only small improvements in predicted GPP at a small number of sites, compared to using the default phenology model.

  11. JULES-crop: a parametrisation of crops in the Joint UK Land Environment Simulator

    Science.gov (United States)

    Osborne, T.; Gornall, J.; Hooker, J.; Williams, K.; Wiltshire, A.; Betts, R.; Wheeler, T.

    2014-10-01

    Studies of climate change impacts on the terrestrial biosphere have been completed without recognition of the integrated nature of the biosphere. Improved assessment of the impacts of climate change on food and water security requires the development and use of models not only representing each component but also their interactions. To meet this requirement the Joint UK Land Environment Simulator (JULES) land surface model has been modified to include a generic parametrisation of annual crops. The new model, JULES-crop, is described and evaluation at global and site levels for the four globally important crops; wheat, soy bean, maize and rice is presented. JULES-crop demonstrates skill in simulating the inter-annual variations of yield for maize and soy bean at the global level, and for wheat for major spring wheat producing countries. The impact of the new parametrisation, compared to the standard configuration, on the simulation of surface heat fluxes is largely an alteration of the partitioning between latent and sensible heat fluxes during the later part of the growing season. Further evaluation at the site level shows the model captures the seasonality of leaf area index and canopy height better than in standard JULES. However, this does not lead to an improvement in the simulation of sensible and latent heat fluxes. The performance of JULES-crop from both an earth system and crop yield model perspective is encouraging however, more effort is needed to develop the parameterisation of the model for specific applications. Key future model developments identified include the specification of the yield gap to enable better representation of the spatial variability in yield.

  12. Jules Verne, la géogenèse des diamants et la revue Nature

    OpenAIRE

    Bollinger , Jean-Claude

    2015-01-01

    International audience; Browsing through recent issues of the respected scientific journal Nature, the author has found a number of explicit references to Jules Verne’s famous novel "Journey to the Center of the Earth". For example, in a paper about the analysis of a solid inclusion within a diamond, diamond formation from a solution is mentioned. But this is in fact a main topic within another and lesser known novel, "The Southern Star". Then a discussion concerning diamond formation is pres...

  13. Impacts of revised PFTs on JULES simulated carbon and moisture fluxes

    Science.gov (United States)

    Harper, Anna; Cox, Peter; Sitch, Stephen; Mercado, Lina; Luke, Catherine; Jupp, Tim; Wiltshire, Andy; Jones, Chris; Friedlingstein, Pierre

    2013-04-01

    JULES is the land surface model in the Hadley Centre GCM, which is used for investigations of climate and climate change. We analyze the impacts on the simulated carbon and moisture fluxes of extending the PFTs in a manner consistent with observed leaf traits. The model currently represents global vegetation with five PFTs (needleleaf and broadleaf trees, C3 and C4 grasses, and shrubs). We add three new PFTs to delineate between deciduous and evergreen trees and shrubs. Since the inception of JULES in the late 90's, a tremendous amount of new data linking leaf traits and potential photosynthesis is available. We use data from the TRY plant trait data base to revise the relationships between leaf area, leaf lifespan, leaf nitrogen content, and Vcmax. In addition, JULES now includes a canopy radiation scheme based on fractions of sunlit and shaded leaves at 10 levels in the canopy. This results in a vertical distribution of nitrogren and Vcmax through the canopy and enables multilayer scaling from leaf to canopy level photosynthesis. The scheme is more physically realistic than previous canopy radiation schemes, but remains to be evaluated outside of the Tropics. Within the constraints of observed values, we optimize new parameter values related to the canopy radiation and photosynthesis, using optimization software developed at the University of Exeter. Impacts on simulated GPP, respiration, and latent heat flux are examined. In particular, we are interested in a better understanding of carbon cycle dynamics in tropical forests. Using data from TRY, carbon fluxes are improved across all PFTs compared to observations from Fluxnet tower sites. We adopt a regional analysis to compare JULES fluxes in certain regions (e.g. tropical forests, and boreal and tropical shrub-dominated landscapes).

  14. [Professor Jules Gavarret (1809-1890) and the application of mathematics and physics to medicine].

    Science.gov (United States)

    Beyneix, A

    2001-01-01

    Professor Jules Gavarret has undertaken pretigious offices, has accumulated various titles and honours and has left an abundant bibliography about physics and chemistry of life phenomenon. To recount the career of one of the academics who were benefited the traditional medicine of the progress achieved in physical and mathematical sciences give us the opportunity of recalling one of the great Parisian personalities of 19th Century who had not been appreciated for too long.

  15. Prosa, poesía y sentimientos en la obra de Jules Supervielle

    OpenAIRE

    Gil-Cepeda Pérez, María de los Ángeles

    1996-01-01

    El artículo hace un repaso de la vida y obra de Jules Supervielle destacando la relación entre la poesía y la prosa, sus cuentos y la temática más significativa de su obra como son la muerte, la vida, las relaciones terrestres, el tiempo y el espacio, el más allá y la metamorfosis.

  16. A critical assessment of the JULES land surface model hydrology for humid tropical environments

    Science.gov (United States)

    Zulkafli, Z.; Buytaert, W.; Onof, C.; Lavado, W.; Guyot, J. L.

    2013-03-01

    Global land surface models (LSMs) such as the Joint UK Land Environment Simulator (JULES) are originally developed to provide surface boundary conditions for climate models. They are increasingly used for hydrological simulation, for instance to simulate the impacts of land use changes and other perturbations on the water cycle. This study investigates how well such models represent the major hydrological fluxes at the relevant spatial and temporal scales - an important question for reliable model applications in poorly understood, data-scarce environments. The JULES-LSM is implemented in a 360 000 km2 humid tropical mountain basin of the Peruvian Andes-Amazon at 12-km grid resolution, forced with daily satellite and climate reanalysis data. The simulations are evaluated using conventional discharge-based evaluation methods, and by further comparing the magnitude and internal variability of the basin surface fluxes such as evapotranspiration, throughfall, and surface and subsurface runoff of the model with those observed in similar environments elsewhere. We find reasonably positive model efficiencies and high correlations between the simulated and observed streamflows, but high root-mean-square errors affecting the performance in smaller, upper sub-basins. We attribute this to errors in the water balance and JULES-LSM's inability to model baseflow. We also found a tendency to under-represent the high evapotranspiration rates of the region. We conclude that strategies to improve the representation of tropical systems to be (1) addressing errors in the forcing and (2) incorporating local wetland and regional floodplain in the subsurface representation.

  17. Täter- und Opfergeschichten. Schuld in Alois Hotschnigs Prosawerken «Aus», «Leonardos Hände» und «Ludwigs Zimmer»

    Directory of Open Access Journals (Sweden)

    Friederike Gösweiner

    2014-05-01

    Full Text Available The assumption this article is based on is that guilt is perhaps the most important theme in Alois Hotschnig’s writing. This article therefore aims at analyzing Hotschnig’s focus on the theme of guilt in his novels. Three examples of Hotschnig’s prose work serve as case studies: his debut Aus, and the two novels Leonardos Hände, and Ludwigs Zimmer. Since guilt seems to be a very important topic in the Austrian literary tradition, this article also tries to establish whether and how Hotschnig takes up this grand Austrian tradition of writing about guilt.

  18. Catálogo de los puentes proyectados por Jules Sagebien en la provincia de Matanzas.

    OpenAIRE

    Luis R. González Arestuche; C. J. Rolo Pico; Rubén A. Delgado Rodríguez

    2014-01-01

    Esta investigación recopila en documento único, el mejor quehacer de uno de los principales forjadores de Matanzas como ciudad y del desarrollo industrial inicial, alcanzado en el siglo XIX, para la demarcación. El respeto hacia la conservación y el rescate del patrimonio construido en la actual provincia homónima, por sus altísimos valores: histórico, cultural y tecnológico, considera la necesidad del conocimiento ciudadano sobre la actividad del francés Jules Sagebien Tavernier. Desde el añ...

  19. William Butcher, Jules Verne inédit, les manuscrits déchiffrés

    OpenAIRE

    Merello, Ida

    2016-01-01

    Les textes de Jules Verne sont des palimpsestes. Ils le sont au sens figuré, nous le savions déjà. Mais ils le sont également au sens propre, comme le montre le bel ouvrage de William Butcher. Ce dernier s’est donné pour objectif d’analyser les manuscrits de Verne parvenus jusqu’à nous. La ressource semble inépuisable : des milliers et des milliers de pages autographes à déchiffrer, à défricher. William Butcher s’est plongé dans ce labeur avec enthousiasme et il en tire de nombreuses informat...

  20. POSITIVISM, INDUSTRIAL REVOLUTION AND URBANISM - UTOPIA AND REALITY IN THE JULES VERNE'S NOVEL "THE BEGUM'S FORTUNE"

    Directory of Open Access Journals (Sweden)

    Daniel H. Valsecchi

    2009-01-01

    Full Text Available The aim of this article is to analyze negative consequences (social, political, psychological and so forth of utopian projects, which crippled society and people by negation of reality and at the same time oblige them to accept these plans. In order to do this we analyze characteristics of two constructions which are thoroughly depicted by Jules Verne: an Arms Fabric (Stahlstadt and a city which was mathematically built (France Ville. Furthermore there are reflections about positivism - i.e. the ground of these projects.

  1. The nuclear heating calculation scheme for material testing in the future Jules Horowitz Reactor

    International Nuclear Information System (INIS)

    Huot, N.; Aggery, A.; Blanchet, D.; Courcelle, A.; Czernecki, S.; Di-Salvo, J.; Doederlein, C.; Serviere, H.; Willermoz, G.

    2004-01-01

    An innovative nuclear heating calculation scheme for materials testing carried out in in the future Jules Horowitz reactor (JHR) is described. A heterogeneous gamma source calculation is first performed at assembly level using the deterministic code APOLLO2. This is followed by a Monte Carlo gamma transport calculation in the whole core using the TRIPOLI4 code. The calculated gamma sources at the assembly level are applied in the whole core simulation using a weighting based on power distribution obtained from the neutronic core calculation. (authors)

  2. Jules Cotard (1840-1889): his life and the unique syndrome which bears his name.

    Science.gov (United States)

    Pearn, J; Gardner-Thorpe, C

    2002-05-14

    Dr. Jules Cotard (1840-1889) was a Parisian neurologist who first described the délire des négations. Cotard's syndrome or Cotard's delusion comprises any one of a series of delusions ranging from the fixed and unshakable belief that one has lost organs, blood, or body parts to believing that one has lost one's soul or is dead. In its most profound form, the delusion takes the form of a professed belief that one does not exist. Encountered primarily in psychoses such as schizophrenia and bipolar disorder, Cotard's syndrome has also been described in organic lesions of the nondominant temporoparietal cortex as well as in migraine. Cotard's delusion is the only self-certifiable syndrome of delusional psychosis. Jules Cotard, a Parisian neurologist and psychiatrist and former military surgeon, was one of the first to induce cerebral atrophy by the experimental embolization of cerebral arteries in animals and a pioneer in studies of the clinicopathologic correlates of cerebral atrophy secondary to perinatal and postnatal pathologic changes. He was the first to record that unilateral cerebral atrophy in infancy does not necessarily lead to aphasia and was also the pioneer of studies of altered conscious states in diabetic hyperglycemia.

  3. SHARP, a first step towards a full sized Jules Verne Launcher

    Energy Technology Data Exchange (ETDEWEB)

    Bertolini, L.R.; Hunter, J.W. [Lawrence Livermore National Lab., CA (United States); Powell, J.R. [Brookhaven National Lab., Upton, NY (United States); Tidman, D.A. [GT-Devices, Inc., Alexandria, VA (United States)

    1993-05-01

    A vital element for space exploration and utilization is the ability to affordably place large quantities of consumables and building material into low earth orbit. Calculations and supportive data indicate this can be done with a large hydrogen gas gun referred to as the Jules Verne Launcher (JVL). We present a design for the JVL based upon the concept of side injecting preheated hydrogen along a long barrel. This dramatically reduces the peak pressures in the launcher as well as the pressures and g-loads at the vehicle. The JVL has the promise of reducing payload delivery costs to Low Earth Orbit (LEO) to below $500/kg. The Super High Altitude Research Project (SHARP) is a conventional two-stage hydrogen gas gun which is configured to launch 5 kg packages on suborbital trajectories. It is the first step towards the much larger Jules Verne system and will demonstrate several important features of the larger system. SHARP is currently in the middle of a series of tests aimed at its first milestone. This is to launch 5 kg at 4 km/sec horizontally. In its inclined configuration SHARP should launch vehicles to apogees in excess of 400 km and ranges in excess of 700 km.

  4. Testing the Joint UK Land Environment Simulator (JULES) for flood forecasting

    Science.gov (United States)

    Batelis, Stamatios-Christos; Rosolem, Rafael; Han, Dawei; Rahman, Mostaquimur

    2017-04-01

    Land Surface Models (LSM) are based on physics principles and simulate the exchanges of energy, water and biogeochemical cycles between the land surface and lower atmosphere. Such models are typically applied for climate studies or effects of land use changes but as the resolution of LSMs and supporting observations are continuously increasing, its representation of hydrological processes need to be addressed adequately. For example, changes in climate and land use can alter the hydrology of a region, for instance, by altering its flooding regime. LSMs can be a powerful tool because of their ability to spatially represent a region with much finer resolution. However, despite such advantages, its performance has not been extensively assessed for flood forecasting simply because its representation of typical hydrological processes, such as overland flow and river routing, are still either ignored or roughly represented. In this study, we initially test the Joint UK Land Environment Simulator (JULES) as a flood forecast tool focusing on its river routing scheme. In particular, JULES river routing parameterization is based on the Rapid Flow Model (RFM) which relies on six prescribed parameters (two surface and two subsurface wave celerities, and two return flow fractions). Although this routing scheme is simple, the prescription of its six default parameters is still too generalized. Our aim is to understand the importance of each RFM parameter in a series of JULES simulations at a number of catchments in the UK for the 2006-2015 period. This is carried out, for instance, by making a number of assumptions of parameter behaviour (e.g., spatially uniform versus varying and/or temporally constant or time-varying parameters within each catchment). Hourly rainfall radar in combination with the CHESS (Climate, Hydrological and Ecological research Support System) meteorological daily data both at 1 km2 resolution are used. The evaluation of the model is based on hourly runoff

  5. Progress report of the French program, and basic design of the Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Ballagny, A.

    1998-01-01

    Since the SILOE reactor was shutdown on December 23, 1997, France has been entirely depending on the OSIRIS reactor to conduct the material and fuel irradiation programmes necessary to the evolution of its nuclear power plants and to prepare the future by analysing further reactor designs which might originate in other strategies, namely in the fuel cycle field. The Jules Horowitz reactor, which operation scheduled to start in 2006, will last 50 years, must cover all irradiation needs including, as far as possible, those related to fast breeder reactor studies, more particularly since the SUPERPHENIX reactor shutdown was announced. RJH reactor studies therefore focus on the increase of flux levels and the search for the limit performance of U 3 Si 2 based MTR fuels. (author)

  6. Jules Verne: de la odisea a la ciencia ficción

    OpenAIRE

    Javier Rodriguez Pequeño

    2018-01-01

    El artículo pretende recordar el importante papel que jugó Jules Verne en la moderna literatura fantástica. Sus Viajes extraordinarios modernizan la odisea clásica y, gracias a la incorporación de la ciencia y a la importancia que concede a la verosimilitud dentro de lo fantástico, crea la ciencia ficción, al tiempo que crea una literatura fantástica basada no el terror, como era común en su época, sino en la fascinación. La utopía es un género muy antiguo pero no le sucede lo mismo a la dist...

  7. Jules Verne's Captain Nemo and French Revolutionary Gustave Flourens:A Hidden Character Model?

    Directory of Open Access Journals (Sweden)

    Leonidas Kallivretakis

    2005-01-01

    Full Text Available This article treats the recent assumption made by Vernian specialist William Butcher that Jules Verne's most famous character, Captain Nemo, is based on the French revolutionary intellectual Gustave Flourens (1838-1871, son of the eminent physiologist J. P. M. Flourens. Gustave Flourens fought in the Cretan insurrection of 1866-1868, later participated in the republican opposition against Napoleon III's imperial regime, eventually became a friend of Karl Marx and was finally killed as a general of the Paris Commune. By comparing step-by-step Verne's inspiration and writing procedures with Flourens' unfolding activities and fame, it is concluded that there is little basis for such an assumption. The article includes also a brief account of the Cretan question in the nineteenth century and of the deep discord between Marx's and Flourens' respective analyses of the Eastern Question.

  8. Jules Verne : un processus d’écriture sous contraintes

    OpenAIRE

    Scheinhardt, Philippe

    2013-01-01

    Devenu célèbre, Jules Verne reçoit souvent la visite de journalistes qui l’interrogent aussi bien sur sa vie que sur son œuvre. De ces entretiens, il ressort que l’écrivain respecte comme tant d’autres des rites de création : habitudes de documentation, méthode de genèse littéraire. Ces rites, en écho à la contrainte externe du programme encyclopédique des Voyages extraordinaires, remplissent la fonction de contraintes internes au service de l’acte créateur. Ils renseignent sur les diverses p...

  9. Incorporating JULES into NASA's Land Information System (LIS) and Investigations of Land-Atmosphere Coupling

    Science.gov (United States)

    Santanello, Joseph

    2011-01-01

    NASA's Land Information System (LIS; lis.gsfc.nasa.gov) is a flexible land surface modeling and data assimilation framework developed over the past decade with the goal of integrating satellite- and ground-based observational data products and advanced land surface modeling techniques to produce optimal fields of land surface states and fluxes. LIS features a high performance and flexible design, and operates on an ensemble of land surface models for extension over user-specified regional or global domains. The extensible interfaces of LIS allow the incorporation of new domains, land surface models (LSMs), land surface parameters, meteorological inputs, data assimilation and optimization algorithms. In addition, LIS has also been demonstrated for parameter estimation and uncertainty estimation, and has been coupled to the Weather Research and Forecasting (WRF) mesoscale model. A visiting fellowship is currently underway to implement JULES into LIS and to undertake some fundamental science on the feedbacks between the land surface and the atmosphere. An overview of the LIS system, features, and sample results will be presented in an effort to engage the community in the potential advantages of LIS-JULES for a range of applications. Ongoing efforts to develop a framework for diagnosing land-atmosphere coupling will also be presented using the suite of LSM and PBL schemes available in LIS and WRF along with observations from the U. S .. Southern Great Plains. This methodology provides a potential pathway to study factors controlling local land-atmosphere coupling (LoCo) using the LIS-WRF system, which will serve as a testbed for future experiments to evaluate coupling diagnostics within the community.

  10. Jules Horowitz Reactor: Organisation for the Preparation of the Commissioning Phase and Normal Operation

    Energy Technology Data Exchange (ETDEWEB)

    Estrade, J.; Fabre, J. L.; Marcille, O. [French Alternative Energies end Atomic Energy Commission, Provence (France)

    2013-07-01

    The Jules Horowitz Reactor (JHR) is a new modern Material Testing Reactor (MTR) currently under construction at CEA Cadarache research centre in the south of France. It will be a major research facility in support to the development and the qualification of materials and fuels under irradiation with sizes and environment conditions relevant for nuclear power plants in order to optimise and demonstrate safe operations of existing power reactors as well as to support future reactors design. It will represent also an important research infrastructure for scientific studies dealing with material and fuel behaviour under irradiation. The JHR will contribute also to secure the production of radioisotope for medical application. This is a key public health stake. The construction of JHR which started in 2007 is going-on with target of commissioning by the end of 2017. The design of the reactor provides modern experimental capacity in support to R and D programs for the nuclear energy for the next 60 years. In parallel to the facility construction, the preparation of the future staff and of the organisation to operate the reactor safely, reliably and efficiently is an important issue. In this framework, many actions are in progress to elaborate: Ο the staffing and the organisational structure for the commissioning test phases and also for normal operation, Ο the documentation in support to the reactor operation (safety analysis report, general operating rules, procedures, instructions, ···), Ο the maintenance, in service and periodic test programs, Ο staff training programs by using dedicated facilities (simulator, ···) Ο commissioning test programs for ensuring that the layout of systems and subcomponents is completed in accordance with the design requirements, the specification performances and the safety criteria. These commissioning tests will also be helpful for transferring the knowledge on the installed systems to the operating group. This paper gives the

  11. Aerial radiological survey of the William H. Zimmer Nuclear Power Station and surrounding area, Moscow, Ohio. Date of survey: July 1981

    International Nuclear Information System (INIS)

    Feimster, E.L.

    1982-07-01

    An aerial radiological survey was performed during the period 29 June through 12 July 1981 over a 250-square-kilometer area centered on the William H. Zimmer Nuclear Power Station near Moscow, Ohio. All gamma ray data were collected along flight lines oriented east to west. The lines were 200 meters apart and flown at an altitude of 122 meters above ground level. Processed data showed that all gamma rays detected within the survey area were those expected from naturally occurring terrestrial background emitters. Count rates obtained from the aerial platform were converted to exposure rates at 1 meter above the ground and are presented in the form of an exposure rate contour map. The resulting exposure rates were between 6 and 12 microroentgens per hour (μR/h), with most of the area ranging from 6 to 9 μR/h. These values include an estimated cosmic ray contribution of 4 μR/h. The exposure rate obtained from soil samples taken from within the survey site displayed positive agreement with the aerial data

  12. LiHo(PO34

    Directory of Open Access Journals (Sweden)

    Mokhtar Férid

    2009-02-01

    Full Text Available Lithium holmium(III polyphosphate(V, LiHo(PO34, belongs to the type I of polyphosphates with general formula ALn(PO34, where A is a monovalent cation and Ln is a trivalent rare earth cation. In the crystal structure, the polyphosphate chains spread along the b-axis direction, with a repeat period of four tetrahedra and 21 internal symmetry. The Li and Ho atoms are both located on twofold rotation axes and are surrounded by four and eight O atoms, leading to a distorted tetrahedral and dodecahedral coordination, respectively. The HoO8 polyhedra are isolated from each other, the closest Ho...Ho distance being 5.570 (1 Å.

  13. Constraining the JULES land-surface model for different land-use types using citizen-science generated hydrological data

    Science.gov (United States)

    Chou, H. K.; Ochoa-Tocachi, B. F.; Buytaert, W.

    2017-12-01

    Community land surface models such as JULES are increasingly used for hydrological assessment because of their state-of-the-art representation of land-surface processes. However, a major weakness of JULES and other land surface models is the limited number of land surface parameterizations that is available. Therefore, this study explores the use of data from a network of catchments under homogeneous land-use to generate parameter "libraries" to extent the land surface parameterizations of JULES. The network (called iMHEA) is part of a grassroots initiative to characterise the hydrological response of different Andean ecosystems, and collects data on streamflow, precipitation, and several weather variables at a high temporal resolution. The tropical Andes are a useful case study because of the complexity of meteorological and geographical conditions combined with extremely heterogeneous land-use that result in a wide range of hydrological responses. We then calibrated JULES for each land-use represented in the iMHEA dataset. For the individual land-use types, the results show improved simulations of streamflow when using the calibrated parameters with respect to default values. In particular, the partitioning between surface and subsurface flows can be improved. But also, on a regional scale, hydrological modelling was greatly benefitted from constraining parameters using such distributed citizen-science generated streamflow data. This study demonstrates the modelling and prediction on regional hydrology by integrating citizen science and land surface model. In the context of hydrological study, the limitation of data scarcity could be solved indeed by using this framework. Improved predictions of such impacts could be leveraged by catchment managers to guide watershed interventions, to evaluate their effectiveness, and to minimize risks.

  14. “Letter to the King” By Jules Destry: from Separatism to Unitarism in Belgium

    Directory of Open Access Journals (Sweden)

    Ella V. Ermakova

    2016-01-01

    Full Text Available Contradictions between the regions of Belgium - Wallonia and Flanders - have a long history associated with uneven political, economic and cultural development of the territories, which in 1830 became parts of an independent state, the Kingdom of Belgium. The "Letter to the King", written by eminent Belgian politician and writer, socialist Jules Destree (1863 - 1936 gg., is one of the most interesting sources on the history of Belgium of this period, It became a kind of manifesto of balance between the ideas of separatism and unitarianism. This article includes excerpts from the "Letter to the King", which were given for the first time in the author's Russian translation and conducted historical criticism of the source. The study is based on a set of scientific methods and approaches, including the principle of scientific objectivity and systematic approach, used in historical research. The main methods are problematic and historical-comparative analysis, classification and comparison of political and historical concepts. An external source of criticism included information about the place and the time of the creation of document, the biography of the author studies; internal critic source recreates the idea of the letter and the background of historical events. Prominent Belgian politician and writer, socialist Jules Destree (1863 - 1936, highly appreciated the personal qualities of King Albert I, appealed to his experience and political vision, describing all the problems Walloons faced in their opposition to the Flemish. Destree in his letter opposed the unequal development of the regions of Belgium and the protectionist policies of the central government in respect to the detriment of Flanders Wallonia. He summarized and formulated the factors that, in his opinion, interfere with the full development of his country. Destree pays great attention to linguistic differences, which were at the heart of conflicts between Walloons and Flemings, and

  15. Love stories can be unpredictable: Jules et Jim in the vortex of life

    Science.gov (United States)

    Dercole, Fabio; Rinaldi, Sergio

    2014-06-01

    Love stories are dynamic processes that begin, develop, and often stay for a relatively long time in a stationary or fluctuating regime, before possibly fading. Although they are, undoubtedly, the most important dynamic process in our life, they have only recently been cast in the formal frame of dynamical systems theory. In particular, why it is so difficult to predict the evolution of sentimental relationships continues to be largely unexplained. A common reason for this is that love stories reflect the turbulence of the surrounding social environment. But we can also imagine that the interplay of the characters involved contributes to make the story unpredictable—that is, chaotic. In other words, we conjecture that sentimental chaos can have a relevant endogenous origin. To support this intriguing conjecture, we mimic a real and well-documented love story with a mathematical model in which the environment is kept constant, and show that the model is chaotic. The case we analyze is the triangle described in Jules et Jim, an autobiographic novel by Henri-Pierre Roché that became famous worldwide after the success of the homonymous film directed by François Truffaut.

  16. Radiation Transport Calculation of the UGXR Collimators for the Jules Horowitz Reactor (JHR)

    Science.gov (United States)

    Chento, Yelko; Hueso, César; Zamora, Imanol; Fabbri, Marco; Fuente, Cristina De La; Larringan, Asier

    2017-09-01

    Jules Horowitz Reactor (JHR), a major infrastructure of European interest in the fission domain, will be built and operated in the framework of an international cooperation, including the development and qualification of materials and nuclear fuel used in nuclear industry. For this purpose UGXR Collimators, two multi slit gamma and X-ray collimation mechatronic systems, will be installed at the JHR pool and at the Irradiated Components Storage pool. Expected amounts of radiation produced by the spent fuel and X-ray accelerator implies diverse aspects need to be verified to ensure adequate radiological zoning and personnel radiation protection. A computational methodology was devised to validate the Collimators design by means of coupling different engineering codes. In summary, several assessments were performed by means of MCNP5v1.60 to fulfil all the radiological requirements in Nominal scenario (TEDE < 25µSv/h) and in Maintenance scenario (TEDE < 2mSv/h) among others, detailing the methodology, hypotheses and assumptions employed.

  17. THE WITCH: A VETO-EUROPEAN MEMORY THROUGH HISTORIAN JULES MICHELET

    Directory of Open Access Journals (Sweden)

    Mónica Elivier Sánchez-González

    2017-01-01

    Full Text Available Reflections about the witch are presented as a challenge that goes through different dimensions. The first is the inaccessibility to a figure that modern societies closed down. However, the Witch encouraged the everyday life of pre-modern societies and peripherical spaces to the central modernity, but the witch still in these spaces. This paradox framing the following discussion. How could pose a witch access to medieval times, without transgressing its rapporteur and impose conditions on it current possibility? The proposal here arises is to work the text of nineteenth-century French historian Jules Michelet as a semantic, where resources of a pre- modern memory, which, to the extent that defines the witch, defines the society in which it is played are played. This paper is not concerned if the witch was real or not, whether or not it was true. Here he retraces his attributes as practices realized veteroeurpea otherness of society, in this case, the exclusion rested with women, the devil, evil. This work is not conclusive, its function is to present a way of looking at the witch, wondering from a specific theoretical corpus: the analysis of memory from systems theory Niklas Luhmann can be formulated.

  18. Love stories can be unpredictable: Jules et Jim in the vortex of life.

    Science.gov (United States)

    Dercole, Fabio; Rinaldi, Sergio

    2014-06-01

    Love stories are dynamic processes that begin, develop, and often stay for a relatively long time in a stationary or fluctuating regime, before possibly fading. Although they are, undoubtedly, the most important dynamic process in our life, they have only recently been cast in the formal frame of dynamical systems theory. In particular, why it is so difficult to predict the evolution of sentimental relationships continues to be largely unexplained. A common reason for this is that love stories reflect the turbulence of the surrounding social environment. But we can also imagine that the interplay of the characters involved contributes to make the story unpredictable-that is, chaotic. In other words, we conjecture that sentimental chaos can have a relevant endogenous origin. To support this intriguing conjecture, we mimic a real and well-documented love story with a mathematical model in which the environment is kept constant, and show that the model is chaotic. The case we analyze is the triangle described in Jules et Jim, an autobiographic novel by Henri-Pierre Roché that became famous worldwide after the success of the homonymous film directed by François Truffaut.

  19. Shape coexistence in 153Ho

    International Nuclear Information System (INIS)

    Dey, Gautam; Sarkar, S.; Chakraborty, A.; Krishichayan; Ghugre, S.S.; Sinha, A.K.; Kshetri, Ritesh; Ray, I.; Ganguly, S.; Pradhan, M.K.; Raut, R.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, S.; Ray Basu, M.; Ganguly, G.; Ray, M.; Basu, S.K.

    2006-01-01

    The motivation for the present work are to firmly assign spins and parities of the excited levels and to investigate shape evolution in 153 Ho as expected phenomenologically from the level spectra and feeding patterns

  20. The Jules Horowitz Reactor (JHR), a European Material Testing Reactor (MTR), with extended experimental capabilities

    International Nuclear Information System (INIS)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P.

    2003-01-01

    The Jules Horowitz Reactor (JHR) is the European MTR (Material Testing Reactor) designed to provide, after 2010, the necessary knowledge for keeping the existing power plants in operation and to design innovative reactors types with new objectives such as: minimizing the radioactive waste production, taking into account additional safety requirements, preventing risks of nuclear proliferation. To achieve such an ambitious objective. The JHR is designed with a high flexibility in order to satisfy the current demand from European industry, research and to be able to accommodate future requirements. The JHR will offer a wide range of performances and services in gathering, in a single site at Cadarache, all the necessary functionalities and facilities for an effective production of results: e.g. fuel fabrication laboratories, preparation of the instrumented devices, interpretation of the experiments, modelling. The JHR must rely on a top level scientific environment based on experts teams from CEA and EC and local universities. With a thermal flux of 7,4.10 14 ncm -2 s -1 and a fast flux of 6,4.10 14 ncm -2 s -1 , it is possible to carry out irradiation experiments on materials and fuels whatever the reactor type considered. It will also be possible to carry out locally, fast neutron irradiation to achieve damage effect up to 25 dpa/year. (dpa = deplacement per atom). The study of the fuels behavior under accidental conditions, from analytical experiments, on a limited amount of irradiated fuel, is a major objective of the project. These oriented safety tests are possible by taking into account specific requirements in the design of the facility such as the tightness level of the containment building, the addition of an alpha hot cell and a laboratory for on line fission products measurement. (author)

  1. Jules Horowitz reactor - Complementary safety assessment in the light of the Fukushima accident

    International Nuclear Information System (INIS)

    2011-01-01

    This CSA (Complementary Safety Assessment) analyses the robustness of the Jules Horowitz reactor (RJH) to extreme situations such as those that led to the Fukushima accident and proposes a series of improvements. RJH is being built on the Cadarache CEA's site. Robustness is the ability for the facility to withstand events beyond the level for which the facility was designed. Robustness is linked to safety margins but also to the situations leading to a sudden deterioration of the accident sequence (cliff edge effect). Safety is not only a matter of design or of engineered systems, it is also a matter of organization. So issues like RJH's crisis organization, the organization of radiation protection, and work organization via subcontracting are also taken into consideration. This report is divided into 9 main chapters: 1) main features of the RJH facility, 2) identification of cliff edge risks and of equipment essential for safety, 3) earthquake risk, 4) flood risk, 5) risks due to other extreme natural disasters, 6) the loss of electrical power supplies and of cooling systems, 7) management of severe accidents, 8) subcontracting policy, 9) synthesis and list of improvements. This study shows a globally good robustness of the RJH for the considered risks. Nevertheless it can considered relevant to increase the robustness of the plant on a few points: -) to increase the seismic safety margins of some pieces of equipment, -) to increase the robustness of the internal electrical power supplies, -) to increase the fuel cooling capacity, and -) to improve the management of the post-accidental period. (A.C.)

  2. Combined analysis of neutron and photon flux measurements for the Jules Horowitz reactor core mapping

    Energy Technology Data Exchange (ETDEWEB)

    Fourmentel, D.; Villard, J. F.; Lyoussi, A. [DEN Reactor Studies Dept., French Nuclear Energy and Alternative Energies Commission, CEA Cadarache, 13108 Saint Paul-Lez-Durance (France); Reynard-Carette, C. [Laboratoire Chimie Provence LCP UMR 6264, Univ. of Provence, Centre St. Jerome, 13397 Marseille Cedex 20 (France); Bignan, G.; Chauvin, J. P.; Gonnier, C.; Guimbal, P.; Malo, J. Y. [DEN Reactor Studies Dept., French Nuclear Energy and Alternative Energies Commission, CEA Cadarache, 13108 Saint Paul-Lez-Durance (France); Carette, M.; Janulyte, A.; Merroun, O.; Brun, J.; Zerega, Y.; Andre, J. [Laboratoire Chimie Provence LCP UMR 6264, Univ. of Provence, Centre St. Jerome, 13397 Marseille Cedex 20 (France)

    2011-07-01

    We study the combined analysis of nuclear measurements to improve the knowledge of the irradiation conditions in the experimental locations of the future Jules Horowitz Reactor (JHR). The goal of the present work is to measure more accurately neutron flux, photon flux and nuclear heating in the reactor. In a Material Testing Reactor (MTR), nuclear heating is a crucial parameter to design the experimental devices to be irradiated in harsh nuclear conditions. This parameter drives the temperature of the devices and of the samples. The numerical codes can predict this parameter but in-situ measurements are necessary to reach the expected accuracy. For this reason, one objective of the IN-CORE program [1] is to study the combined measurements of neutron and photon flux and their cross advanced interpretation. It should be reminded that both neutron and photon sensors are not totally selective as their signals are due to neutron and photon interactions. We intend to measure the neutron flux by three different kinds of sensors (Uranium Fission chamber, Plutonium Fission chamber and Self Powered Neutron Detector), the photon flux by two different sensors (Ionization chamber and Self Powered Gamma Detector) and the nuclear heating by two different ones (Differential calorimeter and Gamma Thermometer). For the same parameter, we expect that the use of different kinds of sensors will allow a better estimation of the aimed parameter by mixing different spectrum responses and different neutron and gamma contributions. An experimental test called CARMEN-1 is scheduled in OSIRIS reactor (CEA Saclay - France) at the end of 2011, with the goal to map irradiation locations in the reactor reflector to get a first validation of the analysis model. This article focuses on the sensor selection for CARMEN-1 experiment and to the way to link neutron and photon flux measurements in view to reduce their uncertainties but also to better assess the neutron and photon contributions to nuclear

  3. Combined analysis of neutron and photon flux measurements for the Jules Horowitz reactor core mapping

    International Nuclear Information System (INIS)

    Fourmentel, D.; Villard, J. F.; Lyoussi, A.; Reynard-Carette, C.; Bignan, G.; Chauvin, J. P.; Gonnier, C.; Guimbal, P.; Malo, J. Y.; Carette, M.; Janulyte, A.; Merroun, O.; Brun, J.; Zerega, Y.; Andre, J.

    2011-01-01

    We study the combined analysis of nuclear measurements to improve the knowledge of the irradiation conditions in the experimental locations of the future Jules Horowitz Reactor (JHR). The goal of the present work is to measure more accurately neutron flux, photon flux and nuclear heating in the reactor. In a Material Testing Reactor (MTR), nuclear heating is a crucial parameter to design the experimental devices to be irradiated in harsh nuclear conditions. This parameter drives the temperature of the devices and of the samples. The numerical codes can predict this parameter but in-situ measurements are necessary to reach the expected accuracy. For this reason, one objective of the IN-CORE program [1] is to study the combined measurements of neutron and photon flux and their cross advanced interpretation. It should be reminded that both neutron and photon sensors are not totally selective as their signals are due to neutron and photon interactions. We intend to measure the neutron flux by three different kinds of sensors (Uranium Fission chamber, Plutonium Fission chamber and Self Powered Neutron Detector), the photon flux by two different sensors (Ionization chamber and Self Powered Gamma Detector) and the nuclear heating by two different ones (Differential calorimeter and Gamma Thermometer). For the same parameter, we expect that the use of different kinds of sensors will allow a better estimation of the aimed parameter by mixing different spectrum responses and different neutron and gamma contributions. An experimental test called CARMEN-1 is scheduled in OSIRIS reactor (CEA Saclay - France) at the end of 2011, with the goal to map irradiation locations in the reactor reflector to get a first validation of the analysis model. This article focuses on the sensor selection for CARMEN-1 experiment and to the way to link neutron and photon flux measurements in view to reduce their uncertainties but also to better assess the neutron and photon contributions to nuclear

  4. Development of the electron beam welding of the aluminium alloy 6061-T6 for the Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Leblanc, Y.

    2013-01-01

    The aluminium alloy 6061-T6 has been selected for the construction of the Jules Horowitz's reactor vessel. This reactor vessel is pressurized and will be made through butt welding of ∼ 2 cm thick aluminium slabs. The electron beam welding process has been tested and qualified. It appears that this welding process allows: -) welding without pre-heating, -) vacuum welding, -) welding of 100% of the thickness in one passage, -) very low deforming welding process, -) very low density and very low volume of blow holes, -) weak ZAT (Thermal Affected Zones), and -) high reproducibility that permits automation. (A.C.)

  5. Study of the uniform corrosion of an aluminium alloy used for the fuel cladding of the Jules Horowitz experimental reactor

    International Nuclear Information System (INIS)

    Wintergerst, M.

    2008-01-01

    For the Jules Horowitz new material testing reactor, an aluminium base alloy, AlFeNi, will be used for the cladding of the fuel plates. Taking into account the thermal properties of the alloy and of its oxide, the corrosion of the fuel cans presents many problems. The aim of this thesis is to provide a growing kinetic of the oxide layer at the surface of the AlFeNi fuel can in order to predict the life time of fuel element. Thus the mechanism of degradation of the cladding will be describe in order to integrate the different parameters of the operating reactor. (A.L.B.)

  6. ILLICO-HO

    International Nuclear Information System (INIS)

    Ougouag, A.M.; Rajic, H.L.

    1988-01-01

    A self-consistent nodal method has been developed that directly computes the in-node flux shapes. The method renders the use of an approximation for the transverse leakages no longer necessary. These are obtained directly from the available interface net current shapes, interface flux shapes, and in-node fluxes. The order of the transverse leakage expansion on a set of Legendre polynomials is determined by the order chosen for the method. The results yielded are nearly as accurate (0.02% maximum relative assembly power error) as very fine-mesh benchmark solutions. A comprehensive numerical and analytical analysis of the transverse leakage approximation has been performed. It has been shown that the quadratic leakage approximation can be in error by many times its value. The success of the quadratic leakage approximation is attributed to its small effect on the nodal powers. The theory developed shows that the transverse leakages can have shapes that encompass hyperbolic sines and cosines, and hence that their approximation via quadratic expansions should not always be expected to be adequate. The ILLICO-HO method gives much more information (detailed fluxes and interface currents) than comparable finite difference as well as nodal benchmark solution methods

  7. Analysis of Media Stereotypes of the Russian Image in Media Studies in the Student Audience (example: the screen versions of Jules Verne's Novel “Michael Strogoff”

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2014-09-01

    Full Text Available As a result of the analysis students come to the conclusion that the screen adaptations of Jules Verne's novel ''Michael Strogoff'' create, though an oversimplified and adapted to western stereotypes of perception, but a positive image of Russia – as a stronghold of European values at the Asian frontiers, a country with a severe climate, boundless Siberian spacious areas, manly and patriotic warriors, a wise monarchy. At the same time, both Jules Verne's novel and its screen adaptations contain clear-cut western pragmatism – the confidence that if a man has a proper will he can rule his destiny.

  8. Spectroscopy and microchip laser operation of Tm, Ho:KYW crystals with different Ho concentrations

    Science.gov (United States)

    Gusakova, N. V.; Kurilchik, S. V.; Yasukevich, A. S.; Kisel, V. E.; Dashkevich, V. I.; Orlovich, V. A.; Pavlyuk, A. A.; Vatnik, S. M.; Bagaev, S. N.; Kuleshov, N. V.

    2018-02-01

    The spectroscopic properties of Tm, Ho:KYW crystals with different Ho concentrations were investigated. The diode-pumped microchip laser operation of Tm (5 at.%), Ho (0.5 at.%):KYW and Tm (5 at.%), Ho (1 at.%):KYW was demonstrated. The highest, to our knowledge, output power of 480 mW with slope efficiency of 31% for CW Tm (5 at.%), Ho (0.5 at.%):KYW microchip laser was obtained.

  9. Uncertainty and sensitivity analysis for the simulation of a station blackout scenario in the Jules Horowitz Reactor

    International Nuclear Information System (INIS)

    Ghione, Alberto; Noel, Brigitte; Vinai, Paolo; Demazière, Christophe

    2017-01-01

    Highlights: • A station blackout scenario in the Jules Horowitz Reactor is analyzed using CATHARE. • Input and model uncertainties relevant to the transient, are considered. • A statistical methodology for the propagation of the uncertainties is applied. • No safety criteria are exceeded and sufficiently large safety margins are estimated. • The most influential uncertainties are determined with a sensitivity analysis. - Abstract: An uncertainty and sensitivity analysis for the simulation of a station blackout scenario in the Jules Horowitz Reactor (JHR) is presented. The JHR is a new material testing reactor under construction at CEA on the Cadarache site, France. The thermal-hydraulic system code CATHARE is applied to investigate the response of the reactor system to the scenario. The uncertainty and sensitivity study was based on a statistical methodology for code uncertainty propagation, and the ‘Uncertainty and Sensitivity’ platform URANIE was used. Accordingly, the input uncertainties relevant to the transient, were identified, quantified, and propagated to the code output. The results show that the safety criteria are not exceeded and sufficiently large safety margins exist. In addition, the most influential input uncertainties on the safety parameters were found by making use of a sensitivity analysis.

  10. New developments in resonant mixture self-shielding treatment with Apollo code and application to Jules Horowitz reactor core calculation

    International Nuclear Information System (INIS)

    Coste-Delclaux, M.; Aggery, A.; Huot, N.

    2005-01-01

    APOLLO2 is a modular multigroup transport code developed by Cea in Saclay. Until last year, the self-shielding module could only treat one resonant isotope mixed with moderator isotopes. Consequently, the resonant mixture self-shielding treatment was an iterative one. Each resonant isotope of the mixture was treated separately, the other resonant isotopes of the mixture being then considered as moderator isotopes, that is to say non-resonant isotopes. This treatment could be iterated. Last year, we have developed a new method that consists in treating the resonant mixture as a unique entity. A main feature of APOLLO2 self-shielding module is that some implemented models are very general and therefore very powerful and versatile. We can give, as examples, the use of probability tables in order to describe the microscopic cross-section fluctuations or the TR slowing-down model that can deal with any resonance shape. The self-shielding treatment of a resonant mixture was developed essentially thanks to these two models. The calculations of a simplified Jules Horowitz reactor using a Monte-Carlo code (TRIPOLI4) as a reference and APOLLO2 in its standard and improved versions, show that, as far as the effective multiplication factor is concerned, the mixture treatment does not bring an improvement, because the new treatment suppresses compensation between the reaction rate discrepancies. The discrepancy of 300 pcm that appears with the reference calculation is in accordance with the technical specifications of the Jules Horowitz reactor

  11. Main technical options of the Jules Horowitz reactor project to achieve high flux performances and high safety level

    International Nuclear Information System (INIS)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P.

    2003-01-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it and will offer a quite larger experimental field. It has the ambition to provide the necessary nuclear data and to maintain a fission research capability in Europe after 2010. The Jules Horowitz Reactor will represent a significant step in terms of performances and experimental capabilities. This paper will present the main design option resulting from the preliminary studies. The choice of the specific power around 600 kW/I for the reference core configuration is a key decision to ensure the required flux level. Consequently many choices have to be made regarding the materials used in the core and the fuel element design. These involve many specific qualifications including codes validation. The main safety options are based on: - A safety approach based upon the defence-in-depth principle. - A strategy of generic approaches to assess experimental risks in the facility. - Internal events analysis taking into account risks linked to reactor and experiments (e.g., radioactive source-term). - Systematic consideration of external hazards (e.g., earthquake, airplane crash) and internal hazards. - Design of containment to manage and mitigate a severe reactor accident (consideration of 'BORAX' accident, according to french safety practice for MTRs, beyond design basis reactivity insertion accident, involving core melting and core destruction phenomena). (authors)

  12. Main technical options of the Jules Horowitz Reactor project to achieve high flux performances and high safety level

    International Nuclear Information System (INIS)

    Ballagny, A.; Bergamaschi, Y.; Bouilloux, Y.; Bravo, X.; Guigon, B.; Rommens, M.; Tremodeux, P.

    2003-01-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it and will offer a quite larger experimental field. It has the ambition to provide the necessary nuclear data and to maintain a fission research capability in Europe after 2010. The Jules Horowitz Reactor will represent a significant step in terms of performances and experimental capabilities. This paper will present the main design option resulting from the preliminary studies. The choice of the specific power around 600 KW/l for the reference core configuration is a key decision to ensure the required flux level. Consequently many choices have to be made regarding the materials used in the core and the fuel element design. These involve many specific qualifications including codes validation. The main safety options are based on: 1) A safety approach based upon the defence-in-depth principle. 2) A strategy of generic approaches to assess experimental risks in the facility. 3) Internal events analysis taking into account risks linked to reactor and experiments (eg., radioactive source-term). 4) Systematic consideration of external hazards (eg., earthquake, airplane crash) and internal hazards. 5) Design of containment to manage and mitigate a severe reactor accident (consideration of 'BORAX' accident, according to french safety practice for MTRs, beyond design basis reactivity insertion accident, involving core melting and core destruction phenomena). (author)

  13. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor

    International Nuclear Information System (INIS)

    Di Salvo, J.

    2002-01-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  14. The Jules Horowitz Reactor project, a driver for revival of the research reactor community

    International Nuclear Information System (INIS)

    Pere, P.; Cavailler, C.; Pascal, C.

    2010-01-01

    The first concrete of the nuclear island for the Jules Horowitz Reactor (JHR) was poured at the end of July 2009 and construction is ongoing. The JHR is the largest new platform for irradiation experiments supporting Generation II and III reactors, Generation IV technologies, and radioisotope production. This facility, composed of a unique grouping of workshops, hot cells and hot laboratories together with a first-rate MTR research reactor, will ensure that the process, from preparations for irradiation experiments through post-irradiation non-destructive examination, is completed expediently, efficiently and, of course, safely. In addition to the performance requirements to be met in terms of neutron fluxes on the samples (5x10 14 n.cm -2 /sec -1 E>1 MeV in core and 3,6x10 14 n.cm -2 /sec -1 E<0.625 eV in the reflector) and the JHR's considerable irradiation capabilities (more than 20 experiments and one-tenth of irradiation area for simultaneous radioisotope production), the JHR is the first MTR to be built since the end of the 1960s, making this an especially challenging project. The presentation will provide an overview of the reactor, hot cells and laboratories and an outline of the key milestones in the project schedule, including initial criticality in early 2014 and radioisotope production in 2015. This will be followed by a description of the project organization set up by the CEA as owner and future operator and AREVA TA as prime contractor and supplier of critical systems, and a discussion of project challenges, especially those dealing with the following items:accommodation of a broad experimental domain; involvement by international partners making in-kind contributions to the project; ? development of components critical to safety and performance; the revival of engineering of research reactors and experimental devices involving France's historical players in the field of research reactors, and; tools to carry out the project, including computer codes

  15. The Jules Horowitz reactor project, a driver for revival of the research reactor community

    Energy Technology Data Exchange (ETDEWEB)

    Pere, P.; Cavailler, C.; Pascal, C. [AREVA TA, CEA Cadarache - Etablissement d' AREVA TA - Chantier RJH - MOE - BV2 - BP no. 9 - 13115 Saint Paul lez Durance (France); CS 50497 - 1100, rue JR Gauthier de la Lauziere, 13593 Aix en Provence cedex 3 (France)

    2010-07-01

    The first concrete of the nuclear island for the Jules Horowitz Reactor (JHR) was poured at the end of July 2009 and construction is ongoing. The JHR is the largest new platform for irradiation experiments supporting Generation II and III reactors, Generation IV technologies, and radioisotope production. This facility, composed of a unique grouping of workshops, hot cells and hot laboratories together with a first -rate MTR research reactor, will ensure that the process, from preparations for irradiation experiments through post-irradiation non-destructive examination, is completed expediently, efficiently and, of course, safely. In addition to the performance requirements to be met in terms of neutron fluxes on the samples (5x10{sup 14} n.cm{sup -2}/sec{sup -1} E> 1 MeV in core and 3,6x10{sup 14} n.cm{sup -2}/sec{sup -1} E<0.625 eV in the reflector) and the JHR's considerable irradiation capabilities (more than 20 experiments and one-tenth of irradiation area for simultaneous radioisotope production), the JHR is the first MTR to be built since the end of the 1960's, making this an especially challenging project. The presentation will provide an overview of the reactor, hot cells and laboratories and an outline of the key milestones in the project schedule, including initial criticality in early 2014 and radioisotope production in 2015. This will be followed by a description of the project organization set up by the CEA as owner and future operator and AREVA TA as prime contractor and supplier of critical systems, and a discussion of project challenges, especially those dealing with the following items: - accommodation of a broad experimental domain, - involvement by international partners making in-kind contributions to the project, - development of components critical to safety and performance, - the revival of engineering of research reactors and experimental devices involving France's historical players in the field of research reactors, and

  16. Energy levels of Ho3+ in HoCl63-

    International Nuclear Information System (INIS)

    Tanner, P.A.

    1987-01-01

    The 5 S 2 , 5 F 4 , 5 F 2 , 3 K 8 , 5 G 6 , 5 F 1 , 5 G 5 5 I 8 absorption spectra of Cs 2 NaHoCl 6 have been recorded at temperatures down to that of liquid helium and new assignments are made for the 5 S 2 , 5 F 4 , 3 K 8 and 5 G 5 terms of HoCl 6 3- . The 5 F 3 → 5 I 8 , 5 F 4 , 5 S 2 → 5 I 7 , 5 I 8 and 5 F 5 → 5 I 7 luminescence transitions of HoCl 6 3- in various elpasolite lattices are reported and assigned, together with luminescence decay measurements. Including the previously reported data, these results enable 57 of the first 60 crystal-field levels of HoCl 6 3- , comprising 14 Lsub(j) terms, to be firmly assigned and tentative assignments are made for the remaining three levels. The agreement between the calculated and observed crystal-field splittings is reasonable. (author)

  17. On 165Ho level scheme

    International Nuclear Information System (INIS)

    Ardisson, Claire; Ardisson, Gerard.

    1976-01-01

    A 165 Ho level scheme was constructed which led to the interpretation of sixty γ rays belonging to the decay of 165 Dy. A new 702.9keV level was identified to be the 5/2 - member of the 1/2 ) 7541{ Nilsson orbit. )] [fr

  18. An improved thermal-hydraulic modeling of the Jules Horowitz Reactor using the CATHARE2 system code

    Energy Technology Data Exchange (ETDEWEB)

    Pegonen, R., E-mail: pegonen@kth.se [KTH Royal Institute of Technology, Roslagstullsbacken 21, SE-10691 Stockholm (Sweden); Bourdon, S.; Gonnier, C. [CEA, DEN, DER, SRJH, CEA Cadarache, 13108 Saint-Paul-lez-Durance Cedex (France); Anglart, H. [KTH Royal Institute of Technology, Roslagstullsbacken 21, SE-10691 Stockholm (Sweden)

    2017-01-15

    Highlights: • An improved thermal-hydraulic modeling of the JHR reactor is described. • Thermal-hydraulics of the JHR is analyzed during loss of flow accident. • The heat exchanger approach gives more realistic and less conservative results. - Abstract: The newest European high performance material testing reactor, the Jules Horowitz Reactor, will support current and future nuclear reactor designs. The reactor is under construction at the CEA Cadarache research center in southern France and is expected to achieve first criticality at the end of this decade. This paper presents an improved thermal-hydraulic modeling of the reactor using solely CATHARE2 system code. Up to now, the CATHARE2 code was simulating the full reactor with a simplified approach for the core and the boundary conditions were transferred into the three-dimensional FLICA4 core simulation. A new more realistic methodology is utilized to analyze the thermal-hydraulic simulation of the reactor during a loss of flow accident.

  19. Emission and transmission tomography systems to be developed for the future needs of Jules Horowitz material testing reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kotiluoto, Petri [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland)], E-mail: petri.kotiluoto@vtt.fi; Wasastjerna, Frej; Kekki, Tommi [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland); Sipilae, Heikki; Banzuzi, Kukka [Oxford Instruments Analytical Oy, Nihtisillankuja 5, P.O.Box 85, FI-02631 Espoo (Finland); Kinnunen, Petri; Heikinheimo, Liisa [VTT Technical Research Centre of Finland, P.O.Box 1000, FI-02044 VTT (Finland)

    2009-08-01

    The new 100 MW Jules Horowitz material testing reactor will be built in Cadarache, France. It will support, for instance, research on new types of innovative nuclear fuel. As a Finnish in-kind contribution, 3D emission and transmission tomography equipment will be delivered for both the reactor and the active component storage pool. The image reconstruction of activities inside the used nuclear fuel will be based on gamma spectrometry measurements. A new type of underwater digital X-ray linear detector array is under development for transmission imaging, based on GaAs and direct conversion of X-rays into an electrical signal. A shared collimator will be used for both emission and transmission measurements. Some preliminary design has been performed. For the current design, the expected gamma spectrometric response of a typical high-purity germanium detector has been simulated with MCNP for minimum and maximum source activities (specified by CEA) to be measured in future.

  20. Jules Verne’s Science fiction and the Physics teaching: an analysis of “Twenty Thousand Leagues Underwater”

    Directory of Open Access Journals (Sweden)

    Júlio César David Ferreira

    2013-04-01

    Full Text Available This article presents the results of a research on the literary work of Jules Verne in the context of the teaching of scientific concepts. In the book "Twenty Thousand Leagues Under the Sea", taking Bakhtin as reference for analysis, we find a systematic and deliberate teaching concepts by Verne. We note a similarity between the situations described by the author and the statements of physical phenomena typical of high school textbooks, with some differences: the richness and complexity of the Verne's narrative, with plots that make highly contextualized the scientific concepts and that expand the possibilities for the reader's understanding. Accordingly, the approach of different genres allows the emergence of interdiscourses that reading can produce, or, in the context of Physics Education, we find in the Verne's literature various points of support for the understanding of scientific knowledge in this school discourse.

  1. Shape coexistence in 153Ho

    Science.gov (United States)

    Pramanik, Dibyadyuti; Sarkar, S.; Saha Sarkar, M.; Bisoi, Abhijit; Ray, Sudatta; Dasgupta, Shinjinee; Chakraborty, A.; Krishichayan, Kshetri, Ritesh; Ray, Indrani; Ganguly, S.; Pradhan, M. K.; Ray Basu, M.; Raut, R.; Ganguly, G.; Ghugre, S. S.; Sinha, A. K.; Basu, S. K.; Bhattacharya, S.; Mukherjee, A.; Banerjee, P.; Goswami, A.

    2016-08-01

    The high-spin states in 153Ho have been studied by the La57(20Ne139,6 n ) reaction at a projectile energy of 139 MeV at the Variable Energy Cyclotron Centre (VECC), Kolkata, India, utilizing an earlier campaign of the Indian National Gamma Array (INGA) setup. Data from γ -γ coincidence, directional correlation, and polarization measurements have been analyzed to assign and confirm the spins and parities of the levels. We have suggested a few additions and revisions of the reported level scheme of 153Ho. The RF-γ time difference spectra have been useful to confirm the half-life of an isomer in this nucleus. From the comparison of experimental and theoretical results, it is found that there are definite indications of shape coexistence in this nucleus. The experimental and calculated lifetimes of several isomers have been compared to follow the coexistence and evolution of shape with increasing spin.

  2. Production development and utilization of Zimmer Station wet FGD by-products. Final report. Volume 6, Field study conducted in fulfillment of Phase 3 titled. Use of FGD by-product gypsum enriched with magnesium hydroxide as a soil amendment

    Energy Technology Data Exchange (ETDEWEB)

    Bigham, J. M. [Ohio State Univ., Wooster, OH (United States). Ohio Agricultural Research Development Center; Soto, U. I. [Ohio State Univ., Wooster, OH (United States). Ohio Agricultural Research Development Center; Stehouwer, R. C. [Ohio State Univ., Wooster, OH (United States). Ohio Agricultural Research Development Center; Yibirin, H. [Ohio State Univ., Wooster, OH (United States). Ohio Agricultural Research Development Center

    1999-04-30

    A variety of flue gas desulfurization (FGD) technologies have been developed to meet environmental restrictions imposed by the federal Clean Air Act and its amendments. These technologies include wet scrubber systems that dramatically reduce sulfur dioxide (SO2) emissions. Although such systems are effective, they also produce large volumes of sludge that must be dewatered, stabilized, and disposed of in landfills. Disposal is an expensive and environmentally questionable process for which suitable alternatives are needed. Wet scrubbing of flue gases with magnesium (Mg)-enhanced lime has the potential to become a leading FGD technology. When combined with aforced oxidation system, the wet sludges resulting from this process can be modified and refined to produce gypsum (CaS04∙2H2O) and magnesium hydroxide [Mg(OH)2] of sufficient purity for beneficial re-use in the construction (wallboard) and pharmaceutical industries. The pilot plant at the CINERGY Zimmer Station near Cincinnati can also produce gypsum by-products formulated to contain varying amounts of Mg(OH)2- Such materials may have value to the agriculture, forestry, and lawn-care industries as soil "conditioners", liming agents, and nutritional supplements capable of supplying calcium (Ca), Mg, and sulfur (S) for plant growth. This report describes three field studies designed to evaluate by-product gypsum and Mg-gypsum from the Zimmer Station power plant as amendments for improving the quality of mine spoils and agricultural soils that were unproductive because of phytotoxic levels of dissolved aluminum (Al) and low pH. The technical literature suggests that gypsum may be more effective than agricultural limestone for ameliorating Al toxicity below the immediate zone of application. Such considerations are important for deep-rooted plant species that attempt to utilize water and nutrients occurring at depth in the spoil/soil.

  3. Magnetic excitations in Ho2Co17 and Ho2Fe17

    International Nuclear Information System (INIS)

    Clausen, K.N.

    1981-01-01

    The low energy part ( 2 Co 17 and Ho 2 Fe 17 have been measured along the three high symmetry directions at a temperature of 4.2 K, using the inelastic neutron scattering technique. The resulting magnon dispersion relations have been interpreted using linear spin wave theory with a Hamiltonian including single ion crystal field anisotropy and isotropic exchange between spatially well localized spins. The R 2 T 17 structure contains two different Ho sites, with the same point symmetry, and from the spin wave results it was concluded that the crystal field anisotropy of the two Ho sites in both Ho 2 Co 17 and Ho 2 Fe 17 were identical. The deduced crystal field parameters for Ho 2 Fe 17 were slightly larger than for Ho 2 Co 17 , and the parameters were of the same order of magnitude as for pure Ho. For Ho 2 Fe 17 the Fe-Fe exchange was found to be anisotropic, and for both compounds the magnetic ordering temperatures of 1178 K for Ho 2 Co 17 and 335 K for Ho 2 Fe 17 were determined by the strong positive 3d-3d exchange. (Auth.)

  4. The future Jules Horowitz material testing reactor: An opportunity for developing international collaborations on a major European irradiation infrastructure

    International Nuclear Information System (INIS)

    Parrat, D.; Bignan, G.; Maugard, B.; Gonnier, C.; Blandin, C.

    2015-01-01

    Development process of a fuel product or a nuclear material before using at an industrial scale in a power reactor ranges from characterization of the material itself under neutronic flux up to its qualification in accidental conditions. Irradiations in Material Testing Reactors (MTRs) are in practice the basis of the whole process, in complement of prediction capabilities gained by modelling. Dedicated experimental reactors play also an important complementary role for some specific integral tests (e.g. RIA tests). Irradiations of precursors in power reactors are often limited to products which present a slight design evolution compare to the standard product or are implemented for further tests when a statistical approach is useful for defining a safety criterion. However European MTR park status is characterized by ageing infrastructures, which could cause operational issues in coming years, either on technological or on safety point of views. Moreover some specific supplies related to the public demand could be strongly affected (e.g. radiopharmaceutical targets). To avoid a lack in irradiation capacity offer at European level, CEA launched the Jules Horowitz Material Testing Reactor (JHR) international program, in the frame of a Consortium gathering also EDF (FR), AREVA (FR), European Commission (EU), SCK.CEN (BE), VTT (FI), CIEMAT (SP), STUDSVIK (SE), UJV (CZ), NNL (UK), IAEC (IL), DAE (IN) and as associated partnership: JAEA (JP). Some institutions in this list are themselves the flagship of a national Consortium. Discussions for enlarging participation are on-going with other countries, as JHR Consortium is open to new member entrance until JHR completion. The Jules Horowitz Material Testing Reactor (JHR MTR) is under construction at CEA Cadarache in southern France and will be an important international User Facility for R&D in support to the nuclear industry, research centres, regulatory bodies and TSO, and academic institutions. It represents a unique

  5. Level structure of 154Ho

    Science.gov (United States)

    Moon, Chang-Bum; Komatsubara, Tetsuro; Furuno, Kohei

    2013-10-01

    The excited states of the odd-odd 154Ho nucleus have been studied by using in-beam γ-ray spectroscopy with the 141Pr (16O, 3n) 154Ho reaction at Elab=75 MeV. The beam was provided by the 12UD Pelletron accelerator at the University of Tsukuba. In this work, the complicated decay pattern of low energy transitions just above the T1/2=3.10 min isomer have been established. In addition, a number of new states and γ-ray transitions, especially those associated with energetically favored band termination, have been observed for the first time in 154Ho. A negative collective band and its signature partner built on the 11- level are interpreted as being based on the πh11/2⊗νi13/2 configuration. A positive band built on the 10+ level is based on the πh11/2⊗νh9/2 configuration while another positive band built on the 9+ level is being associated with the πh11/2⊗νf7/2 configuration. An energetically favored level Jπ=19- can be interpreted as being attributed to the πh11/2⊗νi13/2 configuration coupled to the 8+ state in neighboring core 152Dy, namely, a four-quasiparticle alignment based on the [πh11/2νi13/2]11-⊗[ν(h9/2f7/2)]8- configuration. Another energetically favored state at Jπ=27- is assigned the six-quasiparticle [π(h11/2)3]27/2-⊗[ν(f7/2h9/2i13/2)]27/2- configuration.

  6. La "Carta a los maestros" de Jules Ferry (1883 y el laicismo escolar de la IIIª República francesa

    Directory of Open Access Journals (Sweden)

    Juan Manuel FERNÁNDEZ SORIA

    2010-03-01

    Full Text Available RESUMEN: Partiendo del valor histórico —de lo que es una muestra su influencia en la política educativa de la Segunda República española— y de la proyección de su legado en nuestros días de la «Carta a los Maestros» (1883 del ministro francés de Instrucción Pública, Jules Ferry, este trabajo se acerca a la vida de su autor y a su política educativa para analizar luego con mayor profundidad los aspectos más sobresalientes del documento —que transcribimos en francés y castellano—, especialmente el laicismo escolar, como medio de establecer una escuela nacional y de fundación de la República, la defensa de la moral común y positiva, los modos y procedimientos —tanto directos como indirectos— de su enseñanza, así como el papel del maestro y del manual en la educación moral y cívica del futuro ciudadano. ABSTRACT: Starting with the historic value —of which it is an example its influence in the educational policy of the Second Republic— and with the influence that remains in our days, of the legate of the «Elementary Schoolteacher’s Letter», written by Jules Ferry, French minister of the Public Instruction, this piece of work approaches to its author’s life and to its educational policy in order to analyse later in greater detail the most relevant aspects of the document —which we reproduce in Spanish and French— specially the scholastic laicism as a way to establish a national school, and the foundation of the Republic, the defence of common and positive morality, the ways and procedures, both direct and indirect, of its teaching, and also the role of schoolteachers and the guide in the moral and civic education of the future citizens.

  7. Further evaluation of wetland emission estimates from the JULES land surface model using SCIAMACHY and GOSAT atmospheric column methane measurements

    Science.gov (United States)

    Hayman, Garry; Comyn-Platt, Edward; McNorton, Joey; Chipperfield, Martyn; Gedney, Nicola

    2016-04-01

    The atmospheric concentration of methane began rising again in 2007 after a period of near-zero growth [1,2], with the largest increases observed over polar northern latitudes and the Southern Hemisphere in 2007 and in the tropics since then. The observed inter-annual variability in atmospheric methane concentrations and the associated changes in growth rates have variously been attributed to changes in different methane sources and sinks [2,3]. Wetlands are generally accepted as being the largest, but least well quantified, single natural source of CH4, with global emission estimates ranging from 142-284 Tg yr-1 [3]. The modelling of wetlands and their associated emissions of CH4 has become the subject of much current interest [4]. We have previously used the HadGEM2 chemistry-climate model to evaluate the wetland emission estimates derived using the UK community land surface model (JULES, the Joint UK Land Earth Simulator) against atmospheric observations of methane, including SCIAMACHY total methane columns [5] up to 2007. We have undertaken a series of new HadGEM2 runs using new JULES emission estimates extended in time to the end of 2012, thereby allowing comparison with both SCIAMACHY and GOSAT atmospheric column methane measurements. We will describe the results of these runs and the implications for methane wetland emissions. References [1] Rigby, M., et al.: Renewed growth of atmospheric methane. Geophys. Res. Lett., 35, L22805, 2008; [2] Nisbet, E.G., et al.: Methane on the Rise-Again, Science 343, 493, 2014; [3] Kirschke, S., et al.,: Three decades of global methane sources and sinks, Nature Geosciences, 6, 813-823, 2013; [4] Melton, J. R., et al.: Present state of global wetland extent and wetland methane modelling: conclusions from a model inter-comparison project (WETCHIMP), Biogeosciences, 10, 753-788, 2013; [5] Hayman, G.D., et al.: Comparison of the HadGEM2 climate-chemistry model against in situ and SCIAMACHY atmospheric methane data, Atmos. Chem

  8. AN ELISA ASSAY FOR HEME OXYGENASE (HO-1)

    Science.gov (United States)

    An ELISA assay for heme oxygenase (HO-l ) Abstract A double antibody capture ELISA for the HO-l protein has been developed to separately quantitate HO-I protein. The use of 2.5% NP40 detergent greatly assists in freeing HO-l protein from membranes and/or other cel...

  9. A review of the current thermal-hydraulic modeling of the Jules Horowitz Reactor: A loss of flow accident analysis

    International Nuclear Information System (INIS)

    Pegonen, R.; Bourdon, S.; Gonnier, C.; Anglart, H.

    2014-01-01

    Highlights: • CEA methodology for thermal-hydraulic calculations in the JHR reactor is described. • Thermal-hydraulics of the JHR is analyzed during LOFA using CATHARE and FLICA4. • Safety criteria, important modeling parameters and correlations are presented. • Possible improvements of the current methodology are discussed and proposed. - Abstract: The newest European high performance material testing reactor, the Jules Horowitz Reactor, will support existing and future nuclear reactor designs. The reactor is under construction at CEA Cadarache research center in France and is expected to start operation at the end of this decade. R and D and analytical works have already been performed to set-up the methodology for thermal-hydraulic calculations of the reactor. This paper presents the off-line coupled thermal-hydraulic modeling of the reactor using the CATHARE system code and the FLICA4 core analysis code. The main objective of the present work is to analyze the thermal-hydraulic calculations of the reactor during the loss of flow accident using CEA methodology. Possible improvements of the current methodology are shortly discussed and suggested

  10. Geometrical modification transfer between specific meshes of each coupled physical codes. Application to the Jules Horowitz research reactor experimental devices

    International Nuclear Information System (INIS)

    Duplex, B.

    2011-01-01

    The CEA develops and uses scientific software, called physical codes, in various physical disciplines to optimize installation and experimentation costs. During a study, several physical phenomena interact, so a code coupling and some data exchanges between different physical codes are required. Each physical code computes on a particular geometry, usually represented by a mesh composed of thousands to millions of elements. This PhD Thesis focuses on the geometrical modification transfer between specific meshes of each coupled physical code. First, it presents a physical code coupling method where deformations are computed by one of these codes. Next, it discusses the establishment of a model, common to different physical codes, grouping all the shared data. Finally, it covers the deformation transfers between meshes of the same geometry or adjacent geometries. Geometrical modifications are discrete data because they are based on a mesh. In order to permit every code to access deformations and to transfer them, a continuous representation is computed. Two functions are developed, one with a global support, and the other with a local support. Both functions combine a simplification method and a radial basis function network. A whole use case is dedicated to the Jules Horowitz reactor. The effect of differential dilatations on experimental device cooling is studied. (author) [fr

  11. The Jules Horowitz reactor: complementary safety evaluation in the light of the Fukushima 1 nuclear power station accident

    International Nuclear Information System (INIS)

    2011-01-01

    This report proposes a complementary safety evaluation of the Jules Horowitz reactor in Cadarache (INB 172), one of the French basic nuclear installations (BNI, in French INB) in the light of the Fukushima accident. This evaluation takes the following risks into account: risks of flooding, earthquake, loss of power supply and loss of cooling, in addition to operational management of accident situations. It presents the main characteristics of the installation, identifies the risks of a cliff effect and the main structures and equipment, evaluates the seismic risk (installation sizing, installation conformity, margin evaluation), evaluates the flooding risk (installation sizing, installation conformity, margin evaluation), briefly examines other extreme natural phenomena (extreme meteorological conditions related to flooding, earthquake or flooding with a higher level than that for which the installation is designed). It analyzes the risk of a loss of power supply and of cooling (loss of external and internal electric sources, loss of the ultimate cooling system). It analyzes the management of severe accidents: crisis management organization, available intervention means, robustness of available means. It discusses the conditions of the use of subcontractors

  12. The Jules Horowitz reactor, a new high performance European material testing reactor open to international users: present status and objectives

    International Nuclear Information System (INIS)

    Iracane, D.; Bignan, G.

    2010-01-01

    The development of nuclear power as a sustainable and competitive energy source will continue to require research and development of fuel and material behaviour under irradiation. This necessitates a high performance material testing reactor (MTR). Facing the obsolescence of most of the existing MTR in Europe, France decided a few years ago the construction of the RJH (Jules Horowitz reactor). RJH is designed, built and will be operated as an international user facility. A first set of experimental hosting devices is being designed. For instance, there are the in-core CALIPSO Nak integrated loop for material studies and other loops for fuel studies under nominal or off-normal or accidental conditions. The RJH international program will focus on the following subjects: -) fuel reliability, assessed through power ramps tests and post-irradiation examination; -) Loss of coolant tests done out-of-pile in a first phase and in-pile in a possible second phase; and -) source term tests addressing fission products release. The paper reports also the point of view of VATTENFALL (a Swedish power utility), as a potential European RJH user. (A.C.)

  13. HORUS3D/TH: thermal-hydraulic modelling of the Jules Horowitz reactor core with FLICA4

    International Nuclear Information System (INIS)

    Royer, E.; Gregoire, O.; Magnaud, J.P.; Roux, L.; Masson, X.

    2007-01-01

    Cea is planning to build a new pool type reactor as irradiation facility in Cadarache, France: the Jules Horowitz Reactor (JHR). For this purpose, a simulation program is carried out at Cea: HORUS3D, aimed at modeling neutronics, radio-protection and thermal-hydraulics. Advanced features of the thermal-hydraulics component of this simulation program (HORUS3D/TH) are presented in the paper. HORUS3D/TH is based on the FLICA4 thermalhydraulic code. Numerically the main features of HORUS3D/TH are unstructured mesh grids and non-conform mappings. From a phenomenological point of view, flows under study range from high velocity forced convection to natural convection regimes. Steady and transient regimes have been simulated. The validation of physical models used is an important part of HORUS3D project. For thermohydraulics, this validation relies on the SULTAN-RJH experimental facility and fine scale CFD simulations. We have shown in this paper that it is possible to calibrate the macroscopic heat exchange correlation in the forced convection regime and under very high heat fluxes thanks to low Reynolds fine scale calculations. We particularly underline how to cope with the difficulties due to the complex geometry (cylindrical fuel assemblies, made of curved plates) and very high pressure drops and heat fluxes

  14. Reaction rate constant of HO2+O3 measured by detecting HO2 from photofragment fluorescence

    Science.gov (United States)

    Manzanares, E. R.; Suto, Masako; Lee, Long C.; Coffey, Dewitt, Jr.

    1986-01-01

    A room-temperature discharge-flow system investigation of the rate constant for the reaction 'HO2 + O3 yields OH + 2O2' has detected HO2 through the OH(A-X) fluorescence produced by photodissociative excitation of HO2 at 147 nm. A reaction rate constant of 1.9 + or - 0.3 x 10 to the -15th cu cm/molecule per sec is obtained from first-order decay of HO2 in excess O3; this agrees well with published data.

  15. Assessment of regeneration of bone in the extracted third molar sockets augmented using xenograft (CollaPlugTN Zimmer in comparison with the normal healing on the contralateral side

    Directory of Open Access Journals (Sweden)

    Murugan Ranganathan

    2017-01-01

    Full Text Available Introduction: Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved. Materials and Methods: Based upon our clinical experience, the use of bio absorbable collagen wound dressing such as CollaPlugTN has achieved quick healing and more primary wound coverage. Amongst the graft materials collagen is preferable due to its high biocompatibility and hemostatic ability. This study was done to assess the regeneration of bone in the extracted third molar sockets using xenograft (CollaPlugTN-Zimmer which was compared with the normal healing on the contra lateral side. The assessment was done to analyze post-operative healing complications and to compare the bone density formed between control site and implant site radiologically. Conclusion: On this basis of this study, the use of collaplugTN appears to be beneficial to the patient in postoperative wound healing and also for better bone formation. The use of this material was advantageous because of its simplicity of application cost effectiveness and availability. There is enhanced wound healing and early bone formation.

  16. Assessment of Regeneration of Bone in the Extracted Third Molar Sockets Augmented Using Xenograft (CollaPlugTN Zimmer) in Comparison with the Normal Healing on the Contralateral Side.

    Science.gov (United States)

    Ranganathan, Murugan; Balaji, M; Krishnaraj, R; Narayanan, Vivek; Thangavelu, Annamalai

    2017-11-01

    Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved. Based upon our clinical experience, the use of bio absorbable collagen wound dressing such as CollaPlug TN has achieved quick healing and more primary wound coverage. Amongst the graft materials collagen is preferable due to its high biocompatibility and hemostatic ability. This study was done to assess the regeneration of bone in the extracted third molar sockets using xenograft (CollaPlug TN -Zimmer) which was compared with the normal healing on the contra lateral side. The assessment was done to analyze post-operative healing complications and to compare the bone density formed between control site and implant site radiologically. On this basis of this study, the use of collaplugTN appears to be beneficial to the patient in postoperative wound healing and also for better bone formation. The use of this material was advantageous because of its simplicity of application cost effectiveness and availability. There is enhanced wound healing and early bone formation.

  17. The Jules Horowitz Reactor - A new High Performance European Material Testing Reactor open to International Users Present Status and Objectives

    International Nuclear Information System (INIS)

    Iracane, Daniel; Bignan, Gilles; Lindbaeck, Jan-Erik; Blomgren, Jan

    2010-01-01

    The development of sustainable nuclear energy requires R and D on fuel and material behaviour under irradiation with a high level of performance in order to meet the needs and challenges for the benefit of industry, research and public bodies. These stakes require a sustainable and secured access to an up-to-date high performance Material Testing Reactor. Following a broad survey within the European Research Area, the international community agreed that the need for Material Test Reactors in support of nuclear power plant safety and operation will continue in the context of sustainable nuclear energy. The Jules Horowitz Reactor project (JHR) copes with this context. JHR is designed as a user facility addressing the needs of the international community. This means: - flexibility with irradiation loops able to reproduce a large variation in operation conditions of different power reactor technologies, - high flux capacity to address Generations II, III, and IV needs. JHR is designed, built and operated as an international user facility because: - Given the maturity and globalization of the industry, domestic tools have no more the required level of economic and technical efficiency. Meanwhile, countries with nuclear energy need an access to high performance irradiation experimental capabilities to support technical skill and guarantee the competitiveness and safety of nuclear energy. - Many research items related to safety or public policy (waste management, etc.) require international cooperation to share costs and benefits of resulting consensus. JHR design is optimised for offering high performance material and fuel irradiation capability for the coming decades. This project is driven and funded by an international consortium gathering vendors, utilities and public stakeholders. This consortium has been set up in March 2007 when the construction began. The construction is in progress and the start of operation is scheduled for 2014. The JHR is a research

  18. Water Will Be the Coal of the Future—The Untamed Dream of Jules Verne for a Solar Fuel

    Directory of Open Access Journals (Sweden)

    Vladimir K. Ryabchuk

    2016-11-01

    Full Text Available This article evokes the futuristic visions of two giants, one a writer, Jules Verne, who foresaw water as the coal of the future, and the other a scientist, Giacomo Ciamician, who foresaw the utilization of solar energy as an energy source with which to drive photochemical and photocatalytic reactions for the betterment of mankind. Specifically, we examine briefly the early work of the 1960s and 1970s on the photosplitting of free water and water adsorbed on solid supports, based mostly on metal oxides, from which both hydrogen and oxygen evolve in the expected stoichiometric ratio of 2 to 1. The two oil crises of the 1970s (1973 and 1979 spurred the interest of researchers from various disciplines (photochemistry, photo-catalysis and photoelectrochemistry in search of a Holy Grail photocatalyst, process, or strategy to achieve efficient water splitting so as to provide an energy source alternative to fossil fuels. Some approaches to the photosplitting of water adsorbed on solid insulators (high bandgap materials; Ebg ≥ 5 eV and semiconductor photocatalysts (metal oxides are described from which we deduce that metal oxides with bandgap energies around 5 eV (e.g., ZrO2 are more promising materials to achieve significant water splitting on the basis of quantum yields than narrower bandgap photocatalysts (e.g., TiO2; Ebg ≈ 3.0–3.2 eV, which tend to be relatively inactive by comparison. Although proof of concept of the photosplitting of water has been demonstrated repeatedly in the last four decades, much remains to be done to find the Holy Grail photocatalyst and/or strategy to achieve significant yields of hydrogen.

  19. Estimation of human absorbed dose for (166)Ho-PAM: comparison with (166)Ho-DOTMP and (166)Ho-TTHMP.

    Science.gov (United States)

    Vaez-Tehrani, Mahdokht; Zolghadri, Samaneh; Yousefnia, Hassan; Afarideh, Hossein

    2016-10-01

    In this study, the human absorbed dose of holmium-166 ((166)Ho)-pamidronate (PAM) as a potential agent for the management of multiple myeloma was estimated. (166)Ho-PAM complex was prepared at optimized conditions and injected into the rats. The equivalent and effective absorbed doses to human organs after injection of the complex were estimated by radiation-absorbed dose assessment resource and methods proposed by Sparks et al based on rat data. The red marrow to other organ absorbed dose ratios were compared with these data for (166)Ho-DOTMP, as the only clinically used (166)Ho bone marrow ablative agent, and (166)Ho-TTHMP. The highest absorbed dose amounts are observed in the bone surface and bone marrow with 1.11 and 0.903 mGy MBq(-1), respectively. Most other organs would receive approximately insignificant absorbed dose. While (166)Ho-PAM demonstrated a higher red marrow to total body absorbed dose ratio than (166)Ho-1,4,7,10-tetraazacyclo dodecane-1,4,7,10 tetra ethylene phosphonic acid (DOTMP) and (166)Ho-triethylene tetramine hexa (methylene phosphonic acid) (TTHMP), the red marrow to most organ absorbed dose ratios for (166)Ho-TTHMP and (166)Ho-PAM are much higher than the ratios for (166)Ho-DOTMP. The result showed that (166)Ho-PAM has significant characteristics than (166)Ho-DOTMP and therefore, this complex can be considered as a good agent for bone marrow ablative therapy. In this work, two separate points have been investigated: (1) human absorbed dose of (166)Ho-PAM, as a potential bone marrow ablative agent, has been estimated; and (2) the complex has been compared with (166)Ho-DOTMP, as the only clinically used bone marrow ablative radiopharmaceutical, showing significant characteristics.

  20. Conversion of homothallic yeast to heterothallism trough HO gene disruption

    CSIR Research Space (South Africa)

    Van Zyl, WH

    1993-04-01

    Full Text Available A simple method was developed for the conversion of homothallic Saccharomyces cerevisiae yeaststrains to heterothallism through HO gene disruption. An integrative ho:: neo disrupted allele was constructed by cloning a dominant selectable marker...

  1. Novostavba rodinného domu

    OpenAIRE

    Manduch, Dávid

    2017-01-01

    Jedná sa o samostatne stojaci, dvojpodlažný, nepodpivničený rodinný dom zastrešený plochou vegetačnou strechou v obci Šalgovce. Súčasťou rodinného domu sú dve drevené terasy. Vstupná terasa sa nachádza pred hlavným vstupom do objektu a terasa pre relax je prístupná z obytnej miestnosti s kuchynským kútom. Z tejto terasy je priamy prístup do záhrady. Hlavný stavebný materiál rodinného domu sú stenové panely EcoCocon - kombinácia dreveného rámu a slamenej výplne Garáž je samostatne stojaci jedn...

  2. Spin Waves in Ho2Co17

    DEFF Research Database (Denmark)

    Clausen, Kurt Nørgaard; Lebech, Bente

    1980-01-01

    Spin wave excitations in a single crystal of Ho2Co17 have been studied at 4.8 and 78 K. The results are discussed in terms of a linear spin wave model. At 78 K both ground state and excited state spin waves are observed.......Spin wave excitations in a single crystal of Ho2Co17 have been studied at 4.8 and 78 K. The results are discussed in terms of a linear spin wave model. At 78 K both ground state and excited state spin waves are observed....

  3. Saigon-Ho Chi Minh City

    NARCIS (Netherlands)

    Nguyen, T.B.; Samsura, D.A.A.; Krabben, E. van der; Le, A.D.; Le, A.-D.

    2016-01-01

    Ho Chi Minh City (HCMC) has existed for over three centuries and has developed into the financial capital and most important economic hub of Vietnam. This profile outlines the history of HCMC's development and its impact on current conditions and physical structure of the city. The paper analyzes

  4. The future Jules Horowitz material test reactor: A major European research infrastructure for sustaining the international irradiation capacity

    International Nuclear Information System (INIS)

    Parrat, D.; Bignan, G.; Chauvin, J.; Gonnier, C.

    2011-01-01

    Multipurpose experimental reactors are now key infrastructures, in complement of prediction capabilities gained thanks to progresses in the modelling, for supporting nuclear energy in terms of safety, ageing management, innovation capacity, economical performances and training. However the European situation in this field is characterized by ageing large infrastructures, which could face to operational issues in the coming years and could jeopardize the knowledge acquisition and the nuclear product qualification. Moreover some specific supplies related to the public demand could be strongly affected (e.g. radiopharmaceutical targets). To avoid a lack in the experimental capacity offer at the European level, the CEA has launched the Jules Horowitz material test reactor (JHR) international program, in the frame of a Consortium gathering EDF (FR), AREVA (FR), the European Commission (EU), SCK.CEN (BE), VTT (FI), CIEMAT (SP), VATTENFALL (SE), UJV (CZ), JAEA (JP) and the DAE (IN). The JHR will be a 100 MW tank pool reactor and will have several experimental locations either inside the reactor core or outside the reactor tank in a reflector constituted by beryllium blocks. Excavation works started mid-2007 on the CEA Cadarache site in the southeast of France. After the construction permit delivery gained in September 2007, building construction began at the beginning of 2009. Reactor start-up is scheduled in 2016. The JHR is designed to offer up-to-date irradiation experimental capabilities for studying nuclear material and fuel behaviour under irradiation in a modern safety frame, mainly due to: 1) High values of fast and thermal neutron fluxes in the core and high thermal neutron flux in the reflector (producing typically twice more material damages per year than available today in European MTRs); 2) A large variety of experimental devices capable to reproduce environment conditions of mainly light water reactors (LWRs) and sodium fast reactors; 3) Several equipment

  5. Measurements of combined neutron and photon fluxes for the accurate characterization of the future Jules Horowitz irradiation reactor experimental conditions

    International Nuclear Information System (INIS)

    Fourmentel, D.

    2013-01-01

    A new Material Testing Reactor (MTR), the Jules Horowitz Reactor (JHR), is under construction at the CEA Cadarache (French Alternatives Energies and Atomic Energy Commission). From 2016 this new MTR will be a new facility for the nuclear research on materials and fuels. The quality of the experiments to be conducted in this reactor is largely linked to the good knowledge of the irradiation conditions. Since 2009, a new research program called IN-CORE1 'Instrumentation for Nuclear radiations and Calorimetry Online in Reactor' is under progress between CEA and Aix-Marseille University in the framework of a joint laboratory LIMMEX2. This program aims to improve knowledge of the neutron and photon fluxes in the RJH core, with one hand, an innovative instrumentation performing mapping of experimental locations, and on the other hand by coupling neutron flux, photon flux and thermal measurements. Neutron flux expected in the JHR core is about 10 15 n.cm -2 .s -1 and nuclear heating up to 20 W.g -1 for a nominal power of 100 MWth. One of the challenges is to identify sensors able to measure such fluxes in JHR experimental conditions and to determine how to analyse the signals delivered by these sensors with the most appropriate methods. The thesis is part of this ambitious program and aims to study the potential and the interest of the combination of radiation measurements in the prospect of a better assessment of the levels of neutron flux, gamma radiation and nuclear heating in the JHR experimental locations. The first step of IN-CORE program is to develop and operate an instrumented device called CARMEN-1 adapted to the mapping of the OSIRIS reactor, then to develop a second version called CARMEN-2 dedicated to experiments in the JHR core, especially for its start-up. This experiment was the opportunity to test all the radiation sensors which could meet the needs of JHR, including recently developed sensors. Reference neutron measurements are performed by activation

  6. Study of the uniform corrosion of an aluminium alloy used for the fuel cladding of the Jules Horowitz experimental reactor; Etude de la corrosion uniforme d'un alliage d'aluminium utilise comme gainage du combustible nucleaire du reacteur experimental Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Wintergerst, M. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DEN/DANS/DMN/SEMI), 91 - Gif-sur-Yvette (France)

    2008-07-01

    For the Jules Horowitz new material testing reactor, an aluminium base alloy, AlFeNi, will be used for the cladding of the fuel plates. Taking into account the thermal properties of the alloy and of its oxide, the corrosion of the fuel cans presents many problems. The aim of this thesis is to provide a growing kinetic of the oxide layer at the surface of the AlFeNi fuel can in order to predict the life time of fuel element. Thus the mechanism of degradation of the cladding will be describe in order to integrate the different parameters of the operating reactor. (A.L.B.)

  7. Insetos em presépios e as "formigas vestidas" de Jules Martin (1832-1906: uma curiosa manufatura paulistana do final do século XIX

    Directory of Open Access Journals (Sweden)

    Dante Martins Teixeira

    2008-01-01

    Full Text Available Present in Brazil since the beginning of Portuguese colonization, crèche nativity scenes were soon adapted to local reality, a propitious circumstance for the appearance of heterodox conceptions and the use of exotic elements of the fauna and flora peculiar to each region. As records about insects are very uncommon, it is noteworthy that females of leaf-cutting ants, Atta sp. (Hymenoptera, Formicidae, were used to compose crèche nativity scenes in São Paulo State. Having subsisted at least up to the decade of 1960, the "ant crèches" of cities such as Embu das Artes could be related to the then famous "dressed ants" created by Jules Martin, a curious manufacture of the city of São Paulo in the last quarter of the 19th century.

  8. Irradiation of fuels and materials in the Jules Horowitz reactor: The 6th European Union JHR co-ordination action (JHR-CA)

    International Nuclear Information System (INIS)

    Iracane, Daniel; Parrat, Daniel

    2005-01-01

    The Fermine thematic network in the 5th FP pointed out the need for a new MTR facility in Europe to answer the continuous need of irradiation capabilities for fission power reactors and fusion facilities and to face the ageing of present MTRs. The Jules Horowitz Reactor (JHR) Project in Cadarache copes with this context, as an international service-oriented user-facility. In the field of nuclear fuels and materials irradiation experiments, a 6th FP co-ordination action, called JHR-CA, has started at the beginning of 2004 for 2 years. The main objective is to network existing expertise on development of a new generation of experimental devices, through definition of conceptual designs, instrumentation and related in-reactor services. This paper presents the outline of the JHR project, the organization of the JHR-CA programme, and a choice of irradiation device conceptual design results. (author)

  9. The Jules Horowitz nuclear complex a plat-form for research and development on nuclear fuel and materials for the 21st century

    International Nuclear Information System (INIS)

    Ballagny, A.; Bouilloux, Y.; Chantoin, P.; Iracane, D.

    2001-01-01

    The CEA intends to build a material test reactor at Cadarache (South of France). This reactor would be the central piece of a wider complex which would include experimental fuel fabrication, destructive and non destructive examinations, in-reactor on line measurement advanced methods and modelling. For 50 years this platform would provide the necessary knowledge to the nuclear industry, the safety authority and to the national decision makers. This material test reactor called Jules Horowitz reactor (JHR) could be a key facility for industry and the central component of the European research area on nuclear fission from 2010. In this paper an overview of the research complex is given and a first approach of the development effort undertaken to meet the requirements in term of : ''time to result, experimental cost, experiment quality and international co-operation. Finally are given several ways of technical development undertaken to meet the above requirements. (orig.)

  10. The Zimmer nuclear to coal conversion

    International Nuclear Information System (INIS)

    Baer, R.H.; Pfund, E.M.; Buchmueller, D.P.; Fletcher, J.R.

    1991-01-01

    This paper discusses the control, protection and monitoring systems employed on the world's first nuclear-to-coal power plant conversion, the philosophies utilized to guide the engineering of these systems and the implementation of those philosophies. Extensive use is made of programmable electronic systems to provide a state-of-the-art plant which does not compromise the proven operating interfaces and philosophies associated with AEP's six operating 1300 MW units. The technologies employed include two distributed digital control systems, a fiber optic-based network of programmable logic controllers, a distributed microprocessor-based annunciator and sequence of events system, and a plant operations computer which accesses each of the preceding systems

  11. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor; Contribution a l'etude des incertitudes des parametres neutroniques d'un coeur compact et heterogene: le reacteur d'irradiation Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Di Salvo, J

    2002-07-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  12. Contribution to the determination of the neutronic parameters uncertainties of a compact heterogeneous core: the material testing Jules Horowitz reactor; Contribution a l'etude des incertitudes des parametres neutroniques d'un coeur compact et heterogene: le reacteur d'irradiation Jules Horowitz

    Energy Technology Data Exchange (ETDEWEB)

    Di Salvo, J

    2002-07-01

    The design studies of the future Material Testing Reactor Jules Horowitz require the development of an adapted neutronic calculation route. To guarantee good accuracy and save time cost, some approximations with deterministic modelling (APOLLO2 / CRONOS2) are needed. As no relevant integral experiments are yet available to ensure the accuracy of the calculation, the results need to be validated by a rigorous methodical approach, which is based on comparison against numerical benchmarks (Monte Carlo TRIPOLI4 code). In order to complete the validation results, sensitivity coefficients of main neutronic parameters to nuclear data are very useful to get an estimate of the final uncertainty on the calculation. Unfortunately, most of covariance information is missing in the recent evaluated files such as JEF-2.2. To generate missing covariance matrices, a method based on the comparison of different independent evaluations is used in this study. Special attention is paid to the determination of sensitivity coefficients, using perturbation methods and direct calculations. This study points out the importance of the non-diagonal elements of the covariance matrices as well as the neutron capture cross section uncertainty of the 27Al in the thermal range. In complement to uncertainty studies, it will be still necessary to obtain integral experimental validation of the Jules Horowitz Reactor neutronic parameters calculations. (author)

  13. Correlating states across isomers in 152Ho isotope

    International Nuclear Information System (INIS)

    Pramanik, Dibyadyuti; Dey, G.; Sarkar, S.; Bisoi, A.; Ray, S.; Kshetri, R.; Ray, I.; Pradhan, M.K.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, M.; Chakraborty, A.; Krishichayan; Ganguly, S.; Ray Basu, M.; Ganguly, G.; Raut, R.; Ghugre, S.S.; Sinha, A.K.; Basu, S.K.

    2011-01-01

    The odd-odd 152 Ho (N = 85) is a very interesting candidate for investigation of interplay of single - particle oblate states and prolate collective states, because it is situated between the N=82 shell closure and the strongly collective N > 87 region. It has been shown that there is a possibility of shape coexistence even at lower spins in 153 Ho. The structural evolution of Ho isotopes from A = 151 to 154 has also been studied. The features observed have been interpreted theoretically using shell model as well as Total Routhian surface calculations. Results have been combined with that for 153 Ho to study the evolution of structural features in these Ho isotopes with increasing neutron numbers and increasing spin. In the present work, experimental data on 152 Ho have been analysed to connect the three groups of transitions and confirm the possibility of a fourth isomer in the excitation spectrum

  14. High spin levels in 151Ho

    International Nuclear Information System (INIS)

    Gizon, J.; Gizon, A.; Andre, S.; Genevey, J.; Jastrzebski, J.; Kossakowski, R.; Moszinski, M.; Preibisz, Z.

    1981-02-01

    We report here on the first study of the level structure of 151 Ho. High spin levels in 151 Ho have been populated in the 141 Pr + 16 O and 144 Sm + 12 C reactions. The level structure has been established up to 6.6 MeV energy and the spins and particles determined up to 49/2 - . Most of the proposed level configurations can be explained by the coupling of hsub(11/2) protons to fsub(7/2) and/or hsub(9/2) neutrons. An isomer with 14 +- 3 ns half-life and a delayed gamma multiplicity equal to 17 +- 2 has been found. Its spin is larger than 57/2 h units

  15. The quantitative analysis of 163Ho source by PIXE

    International Nuclear Information System (INIS)

    Sera, K.; Ishii, K.; Fujioka, M.; Izawa, G.; Omori, T.

    1984-01-01

    We have been studying the electron-capture in 163 Ho as a method for determining the mass of electron neutrino. The 163 Ho sources were produced with the 164 Dy(p,2n) reaction by means of a method of internal irradiation 2 ). We applied the PIXE method to determine the total number of 163 Ho atoms in the source. Proton beams of 3 MeV and a method of ''external standard'' were employed for nondestructive analysis of the 163 Ho source as well as an additional method of ''internal standard''. (author)

  16. William Butcher, Jules Verne inédit : les manuscrits déchiffrés, Lyon, ENS Éditions, coll. « Métamorphoses du livre », 2015, 490 p.

    OpenAIRE

    Scheinhardt, Philippe

    2016-01-01

    C’est un travail de recherche conséquent sur le fonds manuscrit de Jules Verne que propose William Butcher. Ce chercheur anglophone s’intéresse depuis longtemps à la diffusion de cette œuvre qu’il a éditée et traduite. Le goût de la recherche, de la découverte s’affiche dans le titre Jules Verne inédit, avec une désignation de l’objet d’étude, qui ne concerne pas tant le manuscrit que son exégèse, puisqu’on nous invite avec le sous-titre Les manuscrits déchiffrés à l’interprétation des traces...

  17. PENGENDALIAN DALAM PENERBITAN IZIN GANGGUAN (HO

    Directory of Open Access Journals (Sweden)

    Pebriana Marlinda

    2017-04-01

    Full Text Available Abstrak :            Penelitian tentang pengendalian dalam penerbitan izin gangguan (HO di Kecamatan Margahayu Kabupaten Bandung menjelaskan tentang tahap-tahap pengendalian yang dilakukan oleh aparat Kecamatan Margahayu. Pengendalian dilakukan untuk memastikan agar penerbitan izin gangguan (HO berjalan dengan efektif. Namun, masih ada pelaku usaha yang belum memiliki surat izin gangguan (HO ataupun pelaku usaha yang sudah memiliki surat izin gangguan (HO akan tetapi kegiatan usahanya merugkan orang lain seperti sampah yang berserakan, polusi udara, polusi suara, dan lain-lain.                            Metode penelitian yang digunakan adalah metode penelitian deduktif kualitatif dengan teknik pengumpulan data melalui studi kepustakaan dan studi lapangan yang meliputi observasi dan wawancara mendalam. Adapun penentuan informan dalam penelitian ini dipilih berdasarkan pertimbangan-pertimbangan dengan pihak-pihak yang terkait dalam pengendalian. Kemudian data yang diperoleh dari hasil wawancara dipaparkan dengan langkah-langkah yang meliputi: reduksi data, penyajian data, menarik kesimpulan/verifikasi. Teori yang digunakan penulis dalam penelitian ini adalah teori dari Stephen P. Robbins tentang tahap-tahap pengendalian yaitu: mengukur kinerja aktual, membandingkan kinerja aktual dengan standar, dan mengambil tindakan manajerial.                            Kesimpulan dari hasil penelitian ini adalah pengendalian yang dilakukan olehaparat Kecamatan Margahayu telah melalui tahap-tahap pengendalian yaitu: mengukur kinerja aktual, membandingkan kinerja aktual dengan standar, dan mengambil tindakan manajerial. Namun perlu dilakukan penguatan di setiap tahap pengendalian terutama pada tahap mengukur kinerja aktual dan pada tahap mengambil tindakan manajerial                            Penelitian tentang pengendalian dalam penerbitan izin gangguan (HO di Kecamatan

  18. Production development and utilization of Zimmer Station wet FGD by-products. Final report. Volume 5, A laboratory greenhouse study conducted in fulfillment of Phase 2, Objective 2 titled. Use of FGD by-product gypsum enriched with magnesium hydroxide as a soil amendment

    Energy Technology Data Exchange (ETDEWEB)

    Yibirin, H. [Ohio State Univ., Wooster, OH (United States); Stehouwer, R. C. [Ohio State Univ., Wooster, OH (United States); Bigham, J. M. [Ohio State Univ., Wooster, OH (United States); Soto, U. I. [Ohio State Univ., Wooster, OH (United States)

    1997-01-31

    The Clean Air Act, as revised in 1992, has spurred the development of flue gas desulfurization (FGD) technologies that have resulted in large volumes of wet scrubber sludges. In general, these sludges must be dewatered, chemically treated, and disposed of in landfills. Disposal is an expensive and environmentally questionable process for which suitable alternatives must be found. Wet scrubbing with magnesium (Mg)-enhanced lime has emerged as an efficient, cost effective technology for SO2 removal. When combined with an appropriate oxidation system, the wet scrubber sludge can be used to produce gypsum (CaSO4-2H2O) and magnesium hydroxide [Mg(OH)2] of sufficient purity for beneficial re-use. Product value generally increases with purity of the by-product(s). The pilot plant at the CINERGY Zimmer Station near Cincinnati produces gypsum by products that can be formulated to contain varying amounts of Mg(OH)2. Such materials may have agricultural value as soil conditioners, liming agents and sources of plant nutrients (Ca, Mg, S). This report describes a greenhouse study designed to evaluate by-product gypsum and Mg gypsum from the Zimmer Station pilot plant as amendments for improving the quality of agricultural soils and mine spoils that are currently unproductive because of phytotoxic conditions related to acidity and high levels of toxic dissolved aluminum (Al). In particular, the technical literature contains evidence to suggest that gypsum may be more effective than agricultural limestone in modifying soil chemical conditions below the immediate zone of application. Representative samples of by-product gypsum and Mg(OH)2 from the Zimmer Station were initially characterized. The gypsum was of high chemical purity and consisted of well crystalline, lath-shaped particles of low specific surface area. By contrast, the by-product Mg(OH)2 was a high surface area material (50 m2 g

  19. EGR-1 regulates Ho-1 expression induced by cigarette smoke

    International Nuclear Information System (INIS)

    Chen, Huaqun; Wang, Lijuan; Gong, Tao; Yu, Yang; Zhu, Chunhua; Li, Fen; Wang, Li; Li, Chaojun

    2010-01-01

    As an anti-oxidant molecule, heme oxygenase-1 (HO-1) has been implicated in the protection of lung injury by cigarette smoke (CS). The mechanisms regulating its expression have not been defined. In this report, the role of early growth response 1 (EGR-1) in the regulation of Ho-1 expression was investigated. In C57BL/6 mice with CS exposure, HO-1 was greatly increased in bronchial epithelial cells and alveolar inflammatory cells. In primary cultured mouse lung fibroblasts and RAW264.7 cells exposed to cigarette smoke water extract (CSE), an increase in HO-1 protein level was detected. In addition, CSE induced HO-1 expression was decreased in Egr-1 deficient mouse embryo fibroblasts (Egr-1 -/- MEFs). Nuclear localization of EGR-1 was examined in mouse lung fibroblasts after exposure to CSE. Luciferase reporter activity assays showed that the enhancer region of the Ho-1 gene containing a proposed EGR-1 binding site was responsible for the induction of HO-1. A higher increase of alveolar mean linear intercept (Lm) was observed in lung tissues, and a larger increase in the number of total cells and monocytes/macrophages from bronchial alveolar lavage fluid was found in CS-exposed mice by loss of function of EGR-1 treatment. In summary, the present data demonstrate that EGR-1 plays a critical role in HO-1 production induced by CS.

  20. Lattice effects in HoVo(3) single crystal

    NARCIS (Netherlands)

    Sikora, M.; Marquina, C.; Ibarra, M. R.; Nugroho, A. A.; Palstra, T. T. M.

    We report the study of lattice effects in the Mott insulator HoVO3 performed by means of linear thermal expansion on a single crystal in the temperature range 10-290 K. The holmium orthovanadate HoVO3 reveals gradual orbital ordering (OO) below T-OO = 200K and orders antiferromagnetically at T-N =

  1. Fer-Ho Anaphora in Catalan: Semantic and Discourse Properties

    Science.gov (United States)

    Busquets, Joan

    2018-01-01

    This paper considers the anaphoric status of the pro-form "fer-ho" (do it) in Catalan [This paper contains some ideas included in Busquets (2005)]. I discuss some anaphoric properties of "fer-ho" as deep anaphora. I also compare these properties to those of other types of anaphora, like VPE and pseudogapping (pg). I show that…

  2. « Jules Crevaux, l’explorateur aux pieds nus ». Un mythe géographique amazonien

    Directory of Open Access Journals (Sweden)

    Emmanuel Lézy

    2008-12-01

    Full Text Available Le rejet par Claude Lévi Strauss du personnage de l’explorateur organise son exploration de l’Amazonie autant que sa quête de l’Indien. Le scientifique, entre les deux, est situé dans une position équidistante entre la clairvoyance et l’aveuglement. Le « voyage » frappé de la même opprobre est présenté, de façon similaire comme un travestissement du nomadisme indigène. L’exploration des régions du totémisme ou de l’animisme est décrite comme une activité cérébrale, intellectuelle, passant par  l’identification des structures fondamentales de mythes chargés d’organiser la connaissance du monde et ne devant pas grand chose au nécessaire mouvement des pieds. Pourtant, en observant attentivement la polarité doublement négative des pieds d’un explorateur de l’Amazonie, Jules Crevaux, on découvre des structures communes au territoire parcouru et au mythe moderne qui confirment de façon paradoxale la pertinence des analyses de l’anthropologue.The rejection by Lévi Strauss of the explorer organise his own exploration of Amazonia as much as his quest for the Indian. The scientist, between those two characters, holds a medium position between blindness and foresight. The « voyage », stuck by the same despise, is presented as a caricature of indigenous nomadism. The exploration of the countries of totemism and animism is described as a mental, intelectual activity based on the identification of the fundamental structures of the myths organising the knowledge of the world which has nothing to do with the necessary movement of the feet. Nevertheless, the carefull observation of the feet of an amazonian explorer, Jules Crevaux (1847-1882, reveals structures which are common to the covered territory and to a modern mythology. This structures give an unexpected confirmation of the efficiency of the anthropologist’s analyses.

  3. Ho:YLF pumped HBr laser

    CSIR Research Space (South Africa)

    Botha, LR

    2009-10-01

    Full Text Available , “Optically Pumped Mid-Infrared HBr Laser,” IEEE J. Quantum Electron. 30(10), 2395–2400 (1994). 2. C. S. Kletecka, N. Campbell, C. R. Jones, J. W. Nicolson, and W. Rudolph, “Cascade Lasing of Molecular HBr in the Four Micron Region Pumped by a Nd:YAG laser...-Infrared Coherent Sources, (European Physical Society 2009) Invited Talk Mo3. 5. C. Bollig, H. J. Strauss, M. J. D. Esser, W. Koen, M.Schellhorn, D. Preussler, K. Nyangaza, C. Jacobs, E. H. Bernardi and L. R. Botha, “Compact Fibre-Laser-Pumped Ho:YLF Oscillator...

  4. Preparation of .sup.166./sup.Ho-Macroaggregates and .sup.166./sup.Ho-Chitosan for the Radiotherapy

    Czech Academy of Sciences Publication Activity Database

    Kropáček, Martin; Melichar, František; Mirzajevová, Marcela

    2002-01-01

    Roč. 29, č. 2 (2002), s. 382 ISSN 1619-7070 R&D Projects: GA MZd NM6828; GA AV ČR KSK4055109 Keywords : Holmium-166 * 166 Ho-macroaggregates * 166 Ho-chitosan Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  5. Test devices in Jules Horowitz Reactor dedicated to the material studies in support to the current and future nuclear power plants

    International Nuclear Information System (INIS)

    Colin, C.; Pierre, J.; Blandin, C.; Gonnier, G.; Auclair, M.; Rozenblum, F.

    2015-01-01

    The Jules Horowitz Reactor (JHR) is a tank pool Material Testing Reactor with a maximum thermal power designed at 100 MW. JHR is being built in the CEA Cadarache site and will take over the Osiris reactor whose decommissioning is planned. JHR's design allows a large experimental capability (around 20 experiments at the same time) inside the reactor core, close to the fuel with high fast neutron flux or outside the reactor core, in the reflector with higher thermal neutron flux. A special attention has been put on the improvement of the thermal stability and gradients of the interest zones in samples despite strong gamma heating and on an improvement of the instrumentation devoted to the experiments. This paper presents the JHR and its main experimental devices that include the MICA (Material Irradiation Capsule) device, the CALIPSO (in-Core Advanced Loop for Irradiation in Potassium and Sodium) loop, the OCCITANE (Out-of-Core Capsule for Irradiation Testing of Ageing by Neutrons) rig, and the CLOE (Corrosion Loop Experiment) loop. JHR will play an important role for Gen IV reactors: CEA studies the feasibility of transmutation capsules, of metal liquid irradiation loops for JHR

  6. Strategie Elektronického obchodu firmy

    OpenAIRE

    Gašpar, Petr

    2011-01-01

    Moje bakalářská práce se bude zabývat volbou vhodnou strategie pro vybudování elektronického obchodu maloobchodní firmy. V práci se zaměřím na to jak docílit aby firma rozšířila své působení na trhu a to právě pomocí elektronického obchodu. Dále budu ve své práci taky mapovat současnou situaci problematiky elektronických obchodů. Analyzuji trh, konkurenci a na základě těchto údajů zvolím strategii, aby elektronický obchod prosperoval. V praktické části se potom zaměřím na maloobchodní firmu J...

  7. Heterogeneous Uptake of HO2 Radicals onto Atmospheric Aerosols

    Science.gov (United States)

    George, I. J.; Matthews, P. S.; Brooks, B.; Goddard, A.; Whalley, L. K.; Baeza-Romero, M. T.; Heard, D. E.

    2011-12-01

    The hydroxyl (OH) and hydroperoxyl (HO2) radicals, together known as HOx, play a vital role in atmospheric chemistry by controlling the oxidative capacity of the troposphere. The atmospheric lifetime and concentrations of many trace reactive species, such as volatile organic compounds (VOCs), are determined by HOx radical levels. Therefore, the ability to accurately predict atmospheric HOx concentrations from a detailed knowledge of their sources and sinks is a very useful diagnostic tool to assess our current understanding of atmospheric chemistry. Several recent field studies have observed significantly lower concentrations of HO2 radicals than predicted using box models, where HO2 loss onto aerosols was suggested as a possible missing sink [1, 2]. However, the mechanism on HO2 uptake onto aerosols and its impact on ambient HOx levels are currently not well understood. To improve our understanding of this process, we have conducted laboratory experiments to measure HO2 uptake coefficients onto submicron aerosol particles. The FAGE (Fluorescence Assay by Gas Expansion) technique, a highly sensitive laser induced fluorescence based detection method, was used to monitor HO2 uptake kinetics onto aerosol particles in an aerosol flow tube. The application of the FAGE technique allowed for kinetic experiments to be performed under low HO2 concentrations, i.e. [HO2] atomizing dilute salt solutions or by homogeneous nucleation. HO2 uptake coefficients (γ) have been measured for single-component solid and aqueous inorganic salt and organic aerosol particles with a wide range of hygroscopicities. HO2 uptake coefficients on solid particles were below the detection limit (γ < 0.001), whereas on aqueous aerosols uptake coefficients were somewhat larger (γ = 0.001 - 0.008). HO2 uptake coefficients were highest on aerosols containing metal ions, such as Cu and Fe. Humidity and aerosol pH did not significantly impact the reactive HO2 uptake. Preliminary experiments have also

  8. HoCaMA: Home Care Hybrid Multiagent Architecture

    Science.gov (United States)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  9. Study of the aqueous corrosion mechanisms and kinetics of the AlFeNi aluminium based alloy used for the fuel cladding in the Jules Horowitz research reactor

    International Nuclear Information System (INIS)

    Wintergerst, M.

    2009-05-01

    For the Jules Horowitz new material-testing reactor (JHR), an aluminium base alloy, called AlFeNi, will be used for the cladding of the fuel plates. This alloy (Al - 1% Fe - 1% Ni - 1 % Mg), which is already used as fuel cladding, was developed for its good corrosion resistance in water at high temperatures. However, few studies dealing with the alteration process in water and the relationships with irradiation effects have been performed on this alloy. The conception of the JHR fuel requires a better knowledge of the corrosion mechanisms. Corrosion tests were performed in autoclaves at 70 C, 165 C and 250 C on AlFeNi plates representative of the fuel cladding. Several techniques were used to characterize the corrosion scale: SEM, TEM, EPMA, XRD, Raman spectroscopy. Our observations show that the corrosion scale is made of two main layers: a dense amorphous scale close to the metal and a porous crystalline scale in contact with the water. More than the morphology, the chemical compositions of both layers are different. This duplex structure results from a mixed growth mechanism: an anionic growth to develop the inner oxide and a cationic diffusion followed by a dissolution-precipitation process to form the outer one. Dynamic experiments at 70 C and corrosion kinetics measurements have demonstrated that the oxide growth process is controlled by a diffusion step associated to a dissolution/precipitation process. A corrosion mechanism of the AlFeNi alloy in aqueous media has been proposed. Then post-irradiation exams performed on irradiated fuel plates were used to investigate the effects of the irradiation on the corrosion behaviour in the reactor core. (author)

  10. Methodological developments and qualification of calculation schemes for the modelling of photonic heating in the experimental devices of the future Jules Horowitz material testing reactor (RJH)

    International Nuclear Information System (INIS)

    Blanchet, D.

    2006-01-01

    The objective of this work is to develop the modelling of the nuclear heating of the experimental devices of the future Jules Horowitz material testing reactor (RJH). The strong specific nuclear power produced (460 kW/l), induces so intense photonic fluxes which cause heating and large temperature gradients that it is necessary to control it by an adequate design. However, calculations of heating are penalized by the very large uncertainties estimated at a value of about 30% (2*σ) coming from the gaps and uncertainties of the data of gamma emission present in the libraries of basic nuclear data. The experimental program ADAPh aims at reducing these uncertainties. Measurements by thermoluminescent detectors (TLD) and ionisation chambers are carried out in the critical assemblies EOLE (Mox) and Minerve (UO 2 ). The rigorous interpretation of these measurements requires specific developments based on Monte-Carlo simulations of coupled neutron-gamma and gamma-electron transport. The developments carried out are made different in particular by the modelling of cavities phenomena and delayed gamma emissions by the decay of fission products. The comparisons calculation-measurement made it possible to identify a systematic bias confirming a tendency of calculations to underestimate measurements. A Bayesian method of adjustment was developed in order to re-estimate the principal components of the gamma heating and to transpose the results obtained to the devices of the RJH, under conditions clearly and definitely representative. This work made possible to reduce significantly the uncertainties on the determination of the gamma heating from 30 to 15 per cent. (author)

  11. Holmium laser lithotripsy (HoLL) of ureteral calculi

    Science.gov (United States)

    Kuntz, Rainer M.; Lehrich, Karin; Fayad, Amr

    2001-05-01

    The effectiveness and side effects of ureteroscopic HoLL of ureteral stones should be evaluated. In 63 patients (17 female, 46 males) a total of 75 stones of 3-20 mm diameter were treated with ureteroscopic HoLL. 18.7 percent of stones were located in the proximal third, 24.0 percent in the middle third and 57.3 percent in the distal third of the ureter. HoLL was performed with small diameter semirigid and flexible ureteroscopes, 220 or 365 nm flexible laser fibers and a holmium:YAG laser at a power of 5-15 W (0.5-1.0 J, 10- 15 Hz). 47 of 63 patients (74.6 percent) were immediately free of stones, and 8 others (12.6 percent) lost their residual fragments spontaneously within two weeks. Another 2 patients received additional chmolitholysis for uric acid stone fragments, i.e. 90.5 percent of patients were stone free by one sitting of ureterscopic HoLL. Of the remaining 6 patients (9.5 percent) who still had residual calculi 4 weeks after HoLL, 2 asymptomatic patients refused any additional treatment, 2 patients preferred treatment with ESWL, and 2 patients had a successful second HoLL, thereby raising the success rate of ureteroscopic HoLL to 93.7 percent. 2 patients showed contrast medium extravasation on retrograde ureterograms, due to guide wire perforation. No ureteral stricture occurred. In conclusion, transurethral ureteroscopic HoLL proved to be a safe and successful minimal invasive treatment of ureteral calculi.

  12. Speech by Prime Minister Francois Fillon. Visit of the Jules Horowitz experimental reactor works on the Commissariat a l'Energie et aux Energies Alternatives site. Cadarache, May 3, 2010

    International Nuclear Information System (INIS)

    2010-01-01

    In this speech, the French Prime Minister evokes the present context, the importance of strategic technologies, and the challenge of investing in these technologies within a context of reduction of public expenses. He comments the decision of his government to finance research and education activities in different domains, and more specifically in the energy sector with this fourth generation Jules Horowitz experimental reactor. He recalls that the nuclear sector has always been very important to the eyes of the successive French governments, and outlines how this reactor will contribute to reactor operational optimization, lifetime extension and safety, nuclear fuel development, etc.

  13. Návrh ubytovacího rezervačního internetového portálu

    OpenAIRE

    Čurilla, Miroslav

    2010-01-01

    Táto diplomová práca sa zaoberá návrhom ubytovacieho rezervačného internetového portálu. Cieľom práce je navrhnutie systému rezervovania ubytovania v ubytovacích zariadenia optimálnym spôsobom. Vedľajšími cieľmi je navrhnutie hardvérových, softvérových, bezpečnostných, marketingových a ekonomických riešení pri návrhu ubytovacieho rezervačné internetového portálu. This master’s thesis deals with the design of the internet portal for the reservation of accommodation. Its objective is the pro...

  14. Magnetic state controllable critical temperature in epitaxial Ho/Nb bilayers

    Directory of Open Access Journals (Sweden)

    Yuanzhou Gu

    2014-04-01

    Full Text Available We study the magnetic properties of Ho thin films with different crystallinity (either epitaxial or non-epitaxial and investigate their proximity effects with Nb thin films. Magnetic measurements show that epitaxial Ho has large anisotropy in two different crystal directions in contrast to non-epitaxial Ho. Transport measurements show that the superconducting transition temperature (Tc of Nb thin films can be significantly suppressed at zero field by epitaxial Ho compared with non-epitaxial Ho. We also demonstrate a direct control over Tc by changing the magnetic states of the epitaxial Ho layer, and attribute the strong proximity effects to exchange interaction.

  15. Výložník kombinovaného skládkového stroje

    OpenAIRE

    Štursa, Martin

    2013-01-01

    Tato diplomová práce se zabývá konstrukcí částí kombinovaného skládkového stroje určeného pro obsluhu skládky hnědého uhlí u uhelné elektrárny. Nejprve jsou nadefinovány základní parametry stroje a silové účinky zatěžující stroj během provozu. Práce dále obsahuje návrh ocelové konstrukce kolesového výložníku, kolesa, korečků, pohonu kolesa, hřídele, ložisek a dalších částí kolesového výložníku. Tyto součásti jsou ověřeny analytickými nebo konečnoprvkovými výpočty. This master’s thesis deal...

  16. The electron capture in 163Ho experiment - ECHo

    Science.gov (United States)

    Gastaldo, L.; Blaum, K.; Chrysalidis, K.; Day Goodacre, T.; Domula, A.; Door, M.; Dorrer, H.; Düllmann, Ch. E.; Eberhardt, K.; Eliseev, S.; Enss, C.; Faessler, A.; Filianin, P.; Fleischmann, A.; Fonnesu, D.; Gamer, L.; Haas, R.; Hassel, C.; Hengstler, D.; Jochum, J.; Johnston, K.; Kebschull, U.; Kempf, S.; Kieck, T.; Köster, U.; Lahiri, S.; Maiti, M.; Mantegazzini, F.; Marsh, B.; Neroutsos, P.; Novikov, Yu. N.; Ranitzsch, P. C. O.; Rothe, S.; Rischka, A.; Saenz, A.; Sander, O.; Schneider, F.; Scholl, S.; Schüssler, R. X.; Schweiger, Ch.; Simkovic, F.; Stora, T.; Szücs, Z.; Türler, A.; Veinhard, M.; Weber, M.; Wegner, M.; Wendt, K.; Zuber, K.

    2017-06-01

    Neutrinos, and in particular their tiny but non-vanishing masses, can be considered one of the doors towards physics beyond the Standard Model. Precision measurements of the kinematics of weak interactions, in particular of the 3H β-decay and the 163Ho electron capture (EC), represent the only model independent approach to determine the absolute scale of neutrino masses. The electron capture in 163Ho experiment, ECHo, is designed to reach sub-eV sensitivity on the electron neutrino mass by means of the analysis of the calorimetrically measured electron capture spectrum of the nuclide 163Ho. The maximum energy available for this decay, about 2.8 keV, constrains the type of detectors that can be used. Arrays of low temperature metallic magnetic calorimeters (MMCs) are being developed to measure the 163Ho EC spectrum with energy resolution below 3 eV FWHM and with a time resolution below 1 μs. To achieve the sub-eV sensitivity on the electron neutrino mass, together with the detector optimization, the availability of large ultra-pure 163Ho samples, the identification and suppression of background sources as well as the precise parametrization of the 163Ho EC spectrum are of utmost importance. The high-energy resolution 163Ho spectra measured with the first MMC prototypes with ion-implanted 163Ho set the basis for the ECHo experiment. We describe the conceptual design of ECHo and motivate the strategies we have adopted to carry on the present medium scale experiment, ECHo-1K. In this experiment, the use of 1 kBq 163Ho will allow to reach a neutrino mass sensitivity below 10 eV/ c 2. We then discuss how the results being achieved in ECHo-1k will guide the design of the next stage of the ECHo experiment, ECHo-1M, where a source of the order of 1 MBq 163Ho embedded in large MMCs arrays will allow to reach sub-eV sensitivity on the electron neutrino mass.

  17. Speech by Prime Minister Francois Fillon. Visit of the Jules Horowitz experimental reactor works on the Commissariat a l'Energie et aux Energies Alternatives site. Cadarache, May 3, 2010; Discours du Premier ministre Francois FILLON Cadarache, lundi 3 mai 2010. Visite du chantier du Reacteur experimental Jules Horowitz sur le site du Commissariat a l'Energie Atomique et aux Energies Alternatives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    In this speech, the French Prime Minister evokes the present context, the importance of strategic technologies, and the challenge of investing in these technologies within a context of reduction of public expenses. He comments the decision of his government to finance research and education activities in different domains, and more specifically in the energy sector with this fourth generation Jules Horowitz experimental reactor. He recalls that the nuclear sector has always been very important to the eyes of the successive French governments, and outlines how this reactor will contribute to reactor operational optimization, lifetime extension and safety, nuclear fuel development, etc.

  18. Observations of OH and HO2 radicals in coastal Antarctica

    Directory of Open Access Journals (Sweden)

    S. J.-B. Bauguitte

    2007-08-01

    Full Text Available OH and HO2 radical concentrations have been measured in the boundary layer of coastal Antarctica for a six-week period during the austral summer of 2005. The measurements were performed at the British Antarctic Survey's Halley Research Station (75° 35' S, 26° 19' W, using the technique of on-resonance laser-induced fluorescence to detect OH, with HO2 measured following chemical conversion through addition of NO. The mean radical levels were 3.9×105 molecule cm−3 for OH, and 0.76 ppt for HO2 (ppt denotes parts per trillion, by volume. Typical maximum (local noontime levels were 7.9×105 molecule cm−3 and 1.50 ppt for OH and HO2 respectively. The main sources of HOx were photolysis of O3 and HCHO, with potentially important but uncertain contributions from HONO and higher aldehydes. Of the measured OH sinks, reaction with CO and CH4 dominated, however comparison of the observed OH concentrations with those calculated via the steady state approximation indicated that additional co-reactants were likely to have been present. Elevated levels of NOx resulting from snowpack photochemistry contributed to HOx cycling and enhanced levels of OH, however the halogen oxides IO and BrO dominated the CH3O2 – HO2 – OH conversion in this environment, with associated ozone destruction.

  19. Embedding of $^{163}$Ho and $^{166m}$ Ho in the energy absorbers of low temperature metallic magnetic calorimeters

    CERN Multimedia

    The calorimetric measurement of the $^{163}$Ho electron capture spectrum is a promising tool to investigate the electron neutrino mass. A suitable method to embed the source in the detectors is the ion-implantation. This process has already been used to embed $^{163}$Ho ions in micro-fabricated low temperature metallic magnetic prototypes. The $^{163}$Ho electron capture spectrum obtained with these first prototypes is presently the most precise with an energy resolution of $\\Delta$$\\textit{E}$$_{FWHM}$ = 7.6 eV. In order to test the performance of the new generation of low temperature metallic magnetic calorimeters, we propose to perform a $^{163}$Ho ion-implantation on the new chip having two arrays consisting of 32 pixels each. An activity of about 1 Bq per pixel is required. With this new detector array we will be able to achieve a better energy resolution and to acquire a higher statistics which allows for studying the $^{163}$Ho spectral shape. We propose also to perform an ion-implantation of $^{166m}$...

  20. Konstrukce vřeten vícevřetenového soustružnického automatu

    OpenAIRE

    Kráčmar, Tomáš

    2016-01-01

    Obsahem diplomové práce je konstrukce vřeten vícevřetenového soustružnického automatu pro práci z tyče maximálního průměru 7 mm. Práce se zabývá novou koncepcí pohonu vřeten, kde jsou vřetena poháněna externími asynchronními motory přes ozubená kola s vnitřním ozubením uložená vně vřetenového bubnu namísto současného způsobu pohonu centrálními koaxiálními hřídeli. Součástí práce je rešerše vícevřetenových automatů včetně popisu hlavních uzlů, konstrukční návrh, pevnostní výpočty, výpočty trva...

  1. Návrh internetového obchodu pro firmu

    OpenAIRE

    Fikáčková, Barbora

    2007-01-01

    Bakalářské práce analyzuje problémy související s tvorbou internetového obchodu. Obsahuje návrh vhodného řešení pro zlepšení budoucího postavení firmy AMAR marketing s.r.o. a jeho ekonomické zhodnocení. Bachelor work analyzes problems in connection with creation of internet shop. for the firm AMAR marketing s.r.o. It contains analysis of suitable solution, leading to improve future position of the firm AMAR marketing s.r.o. and its econo-mic evulation. A

  2. Proton Radioactivity Measurements at HRIBF: Ho, Lu, and Tm Isotopes

    International Nuclear Information System (INIS)

    Akovali, Y.; Batchelder, J.C.; Bingham, C.R.; Davinson, T.; Ginter, T.N.; Gross, C.J.; Grzywacz, R.; Hamilton, J.H.; Janas, Z.; Karny, M.; Kim, S.H.; MacDonald, B.D.; Mas, J.F.; McConnell, J.W.; Piechaczek, A.; Ressler, J.J.; Rykaczewski, K.; Slinger, R.C.; Szerypo, J.; Toth, K.S.; Weintraub, W.; Woods, P.J.; Yu, C.-H.; Zganjar, E.F.

    1998-01-01

    Two new isotopes, 145 Tm and 140 Ho and three isomers in previously known isotopes, 141m Ho, 150m Lu and 151m Lu have been discovered and studied via their decay by proton emission. These proton emitters were produced at the Holifield Radioactive Ion Beam Facility (HRIBF) by heavy-ion fusion-evaporation reactions, separated in A/Q with a recoil mass spectrometer (RMS), and detected in a double-sided silicon strip detector (DSSD). The decay energy and half-life was measured for each new emitter. An analysis in terms of a spherical shell model is applied to the Tm and Lu nuclei, but Ho is considerably deformed and requires a collective model interpretation

  3. Lattice effects in HoVo3 single crystal

    International Nuclear Information System (INIS)

    Sikora, M.; Marquina, C.; Ibarra, M.R.; Nugroho, A.A.; Palstra, T.T.M.

    2007-01-01

    We report the study of lattice effects in the Mott insulator HoVO 3 performed by means of linear thermal expansion on a single crystal in the temperature range 10-290 K. The holmium orthovanadate HoVO 3 reveals gradual orbital ordering (OO) below T OO =200 K and orders antiferromagnetically at T N =113 K. A first-order structural phase transition takes place at T S ∼38 K, which is probably accompanied by change of the OO type and hence the type of antiferromagnetic spin ordering

  4. The uptake of HO2 radicals to organic aerosols

    Science.gov (United States)

    Matthews, Pascale; Krapf, Manuel; Dommen, Josef; George, Ingrid; Whalley, Lisa; Ingham, Trevor; Baeza-Romero, Maria Teresa; Ammann, Markus; Heard, Dwayne

    2014-05-01

    HOx (OH + HO2) radicals are responsible for the majority of the oxidation in the troposphere and control the concentrations of many trace species in the atmosphere. There have been many field studies where the measured HO2 concentrations have been smaller than the concentration predicted by model calculations [1,2]. The difference has often been attributed to HO2 uptake by aerosols. Organics are a major component of aerosols accounting for 10 - 70 % of their mass [3]. However, there have been very few laboratory studies measuring HO2 uptake onto organic aerosols [4]. Uptake coefficients (γ) were measured for a range of aerosols using a Fluorescence Assay By Gas Expansion (FAGE) detector combined with an aerosol flow tube. HO2 was injected into the flow tube using a moveable injector which allowed first order HO2 decays to be measured along the flow tube both with and without aerosols. Laboratory generated aerosols were made using an atomiser or by homogeneous nucleation. Secondary organic aerosols (SOA) were made using the Paul Scherrer Institute smog chamber and also by means of a Potential Aerosol Mass (PAM) chamber. The total aerosol surface area was then measured using a Scanning Mobility Particle Sizer (SMPS). Experiments were carried out on aerosols containing glutaric acid, glyoxal, malonic acid, stearic acid, oleic acid and squalene. The HO2 uptake coefficients for these species were measured in the range of γ contained elevated levels of transition metal ions. For humic acid the uptake coefficient was highly dependent on humidity and this may be explained by the liquid water content of the aerosols. Measurements were also performed on copper doped aerosols containing different organics. An uptake coefficient of 0.23 ± 0.07 was measured for copper doped ammonium sulphate, however, this was reduced to 0.008 ± 0.009 when EDTA was added in a 1:1 ratio with copper and 0.003 ± 0.004 when oxalic acid was added in a 10:1 ratio with copper. SOA aerosols were

  5. 166Ho-chitosan as a radiation synovectomy agent - biocompatibility study of 166Ho-chitosan in rabbits

    International Nuclear Information System (INIS)

    Kim, Sug Jun; Lee, Soo Yong; Jeon, Dae Geun; Lee Jong Seok

    1997-01-01

    Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the 166 Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the 166 Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that 166 Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs

  6. {sup 166}Ho-chitosan as a radiation synovectomy agent - biocompatibility study of {sup 166}Ho-chitosan in rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sug Jun; Lee, Soo Yong; Jeon, Dae Geun; Seok, Lee Jong [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    1997-01-01

    Radiation synovectomy is a noninvasive therapy that has been investigated as an alternative to surgical synovectomy. It is been successfully employed in the treatment of synovitis in rheumatoid arthrits and other inflammatory arthropathies. We developed the {sup 166}Ho-chitosan complex for possible use as a radiation synovectomy agent. Holmium is the more practical isotope based on its higher radioactivity and logner half-life. And isotope based on its higher radioactivity and logner half-life. And chitosan is ideal and suitable particles based on its soluble and biodegradable characteristics. So we investigated the biocompatibility of the {sup 166}Ho-chitosan complex to evaluated the suitability as a radiation synovectomy agent. In this study, we performed in vivo and in vitro stability test and biodistribution test. Our results indicate that {sup 166}Ho-chitosan may be an effective radiopharmaceutical for radiation synovectomy. (author). 30 refs., 7 tabs.

  7. Electronic transitions of Ho in Pb2Sr2HoCu3O8 observed by inelastic neutron scattering

    International Nuclear Information System (INIS)

    Soderholm, L.; Loong, C.; Xue, J.S.; Hammonds, J.P.; Greedan, J.E.; Maric, M.

    1993-01-01

    The electronic behavior of the 5 I 8 Russell Saunders ground multiplet of Ho 3+ in Pb 2 Sr 2 HoCu 3 O 8 has been investigated using inelastic neutron scattering. We observe ten peaks in the excitation spectra that are associated with crystal field transitions. The peaks are only slightly broader than expected from instrument resolution, indicating that there are no strong interactions between the local Ho f states and the CuO conduction states. Comparing the energies and intensities of the experimental peaks with those expected from modeling convinces us that there are at least three states populated at the temperature of our experiment (15 K), making the assignments of transitions very difficult in the absence of further data

  8. Methodological developments and qualification of calculation schemes for the modelling of photonic heating in the experimental devices of the future Jules Horowitz material testing reactor (RJH); Developpements methodologiques et qualification de schemas de calcul pour la modelisation des echauffements photoniques dans les dispositifs experimentaux du futur reacteur d'irradiation technologiques Jules Horowitz (RJH)

    Energy Technology Data Exchange (ETDEWEB)

    Blanchet, D

    2006-07-01

    The objective of this work is to develop the modelling of the nuclear heating of the experimental devices of the future Jules Horowitz material testing reactor (RJH). The strong specific nuclear power produced (460 kW/l), induces so intense photonic fluxes which cause heating and large temperature gradients that it is necessary to control it by an adequate design. However, calculations of heating are penalized by the very large uncertainties estimated at a value of about 30% (2*{sigma}) coming from the gaps and uncertainties of the data of gamma emission present in the libraries of basic nuclear data. The experimental program ADAPh aims at reducing these uncertainties. Measurements by thermoluminescent detectors (TLD) and ionisation chambers are carried out in the critical assemblies EOLE (Mox) and Minerve (UO{sub 2}). The rigorous interpretation of these measurements requires specific developments based on Monte-Carlo simulations of coupled neutron-gamma and gamma-electron transport. The developments carried out are made different in particular by the modelling of cavities phenomena and delayed gamma emissions by the decay of fission products. The comparisons calculation-measurement made it possible to identify a systematic bias confirming a tendency of calculations to underestimate measurements. A Bayesian method of adjustment was developed in order to re-estimate the principal components of the gamma heating and to transpose the results obtained to the devices of the RJH, under conditions clearly and definitely representative. This work made possible to reduce significantly the uncertainties on the determination of the gamma heating from 30 to 15 per cent. (author)

  9. Methodological developments and qualification of calculation schemes for the modelling of photonic heating in the experimental devices of the future Jules Horowitz material testing reactor (RJH); Developpements methodologiques et qualification de schemas de calcul pour la modelisation des echauffements photoniques dans les dispositifs experimentaux du futur reacteur d'irradiation technologiques Jules Horowitz (RJH)

    Energy Technology Data Exchange (ETDEWEB)

    Blanchet, D

    2006-07-01

    The objective of this work is to develop the modelling of the nuclear heating of the experimental devices of the future Jules Horowitz material testing reactor (RJH). The strong specific nuclear power produced (460 kW/l), induces so intense photonic fluxes which cause heating and large temperature gradients that it is necessary to control it by an adequate design. However, calculations of heating are penalized by the very large uncertainties estimated at a value of about 30% (2*{sigma}) coming from the gaps and uncertainties of the data of gamma emission present in the libraries of basic nuclear data. The experimental program ADAPh aims at reducing these uncertainties. Measurements by thermoluminescent detectors (TLD) and ionisation chambers are carried out in the critical assemblies EOLE (Mox) and Minerve (UO{sub 2}). The rigorous interpretation of these measurements requires specific developments based on Monte-Carlo simulations of coupled neutron-gamma and gamma-electron transport. The developments carried out are made different in particular by the modelling of cavities phenomena and delayed gamma emissions by the decay of fission products. The comparisons calculation-measurement made it possible to identify a systematic bias confirming a tendency of calculations to underestimate measurements. A Bayesian method of adjustment was developed in order to re-estimate the principal components of the gamma heating and to transpose the results obtained to the devices of the RJH, under conditions clearly and definitely representative. This work made possible to reduce significantly the uncertainties on the determination of the gamma heating from 30 to 15 per cent. (author)

  10. Optical transitions of Ho(3+) in oxyfluoride glasses and upconversion luminescence of Ho(3+)/Yb(3+)-codoped oxyfluoride glasses.

    Science.gov (United States)

    Feng, Li; Wu, Yinsu

    2015-05-05

    Optical properties of Ho(3+)-doped SiO2-BaF2-ZnF2 glasses have been investigated on the basis of the Judd-Ofelt theory. Judd-Ofelt intensity parameters, radiative transition probabilities, fluorescence branching ratios and radiative lifetimes have been calculated for different glass compositions. Upconversion emissions were observed in Ho(3+)/Yb(3+)-codoped SiO2-BaF2-ZnF2 glasses under 980nm excitation. The effects of composition, concentration of the doping ions, and excitation pump power on the upconversion emissions were also systematically studied. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Charged black holes in Hořava gravity

    International Nuclear Information System (INIS)

    Janiszewski, Stefan; Karch, Andreas; Robinson, Brandon; Sommer, David

    2014-01-01

    We explore static spherically symmetric black hole solutions allowing a bulk U(1) vector field in the khronometric formulation of Hořava gravity by way of Einstein-Æther. We examine analytic solutions and study numerical results in the limit that the khronon does not backreact on the metric

  12. Programme Note: Realities and Opportunities in Ho Chi Minh City.

    Science.gov (United States)

    Franchet, Chi Nguyen

    1996-01-01

    The current status of street children in Ho Chi Minh City, Vietnam, is characterized by marginalization from society through street vending, begging, theft, and prostitution. Evaluation of a drop-in center serving children without family linkages indicates need for needs assessments, follow-up activities, measurement of individual child progress,…

  13. Phase equilibria of the Mo-Al-Ho ternary system

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yitai; Chen, Xiaoxian; Liu, Hao [Guangxi Univ., Nanning (China). College of Materials Science and Engineering; Guangxi Univ., Nanning (China). Guangxi Key Laboratory of Processing for Non-ferrous Metal and Featured Materials; Zhan, Yongzhong [Guangxi Univ., Nanning (China). College of Materials Science and Engineering; Guangxi Univ., Nanning (China). Guangxi Key Laboratory of Processing for Non-ferrous Metal and Featured Materials; Guangxi Univ., Nanning (China). Center of Ecological Collaborative Innovation for Aluminum Industry

    2017-08-15

    Investigation into the reactions and phase equilibria of transition metal elements (i.e. Mo, Zr, Cr, V and Ti), Al and rare earths is academically and industrially important for the development of both refractory alloys and lightweight high-temperature materials. In this work, the equilibria of the Mo-Al-Ho ternary system at 773 K have been determined by using X-ray powder diffraction and scanning electron microscopy equipped with energy dispersive X-ray analysis. A new ternary phase Al{sub 4}Mo{sub 2}Ho has been found and the other ternary phase Al{sub 43}Mo{sub 4}Ho{sub 6} is observed. Ten binary phases in the Al-Mo and Al-Ho systems, including Al{sub 17}Mo{sub 4} rather than Al{sub 4}Mo, have been determined to exist at 773 K. The homogeneity ranges of AlMo{sub 3} and Al{sub 8}Mo{sub 3} phase are 7.5 at.% and 1 at.%, respectively. According to the phase-disappearing method, the maximum solubility of Al in Mo is about 16 at.%.

  14. Experimental dosimetry of Ho-166 bioglass seed polymer-protected

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, Luciana B.; Campos, Tarcisio P.R. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear. Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares

    2011-07-01

    This study aims to develop experimental dosimetry of Ho-166 bio glass seed for brachytherapy studies using GAFCHROMIC EBT2 radio chromium films. The methodology consists of placement of radio chromium films in a compressed breast phantom, along with bio glass polymer-protected seeds of [Si: Ca: Ho] and [Si: Ca: Ho: Zr]. The bio glass seeds were encapsulated with polyvinyl alcohol, before being activated and used in the study. The bio glass seeds were introduced into the breast phantom, along with radio chromium films for a period of 2 hours. After the exposure time, radio chromium films were removed from phantom and digitized for analysis in ImageDIG 2.0 program, which quantifies the intensity of RGB (Red, Green, Blue). The dose calculation was evaluated by Monte Carlo technique. Experimental and theoretical data were used to calibrate the dose distribution. The results were plotted on graphs and dose iso curves were obtained. As conclusion it is possible to perform dosimetry in Ho-166 seed brachytherapy using radio chromium films, limited to a short exposure time and small activity. (author)

  15. Antiferromagnetism in a 20% Ho-80% Tb alloy single crystal

    DEFF Research Database (Denmark)

    Lebech, Bente

    1968-01-01

    20% Ho-80% Tb exhibits two magnetic phases, similar to those of Tb. The spiral turn angle varies from 31.1° to 21.4°. A minimum effective spin for the occurrence of stable simple ferromagnetic structure at low temperatures is predicted....

  16. Addition of HO-nucleophiles to free and coordinated nitriles

    International Nuclear Information System (INIS)

    Bokach, Nadejda A; Kukushkin, Vadim Yu

    2005-01-01

    The review surveys data on the addition of HO-nucleophiles (water, oximes, hydroxylamines, hydroxamic acids, alcohols) to nitriles. Main methods for C≡N bond activation in nucleophilic addition reactions are discussed. Particular attention is given to activation of nitriles through coordination to metal centres.

  17. Near IR Photolysis of HO2NO2: Supplemental Material

    Science.gov (United States)

    2002-01-01

    MkIV measurements of the volume mixing ratio (VMR) of HO2NO2 at 35 deg N, sunset on Sept. 25, 1993 are given. Measurements of HO2NO2 made between approx. 65 and 70 deg N, sunrise on May 8, 1997 are listed. The uncertainties given are 1 sigma estimates of the measurement precision. Uncertainty in the HO2NO2 line strengths is estimated to be 20%; this is the dominant contribution to the systematic error of the HO2NO2 measurement. Model inputs for the simulations are given. The albedos were obtained from Total Ozone Mapping Spectrometer reflectively data (raw data at ftp://jwocky.gsfc.nasa.gov) for the time and place of observation. Profiles of sulfate aerosol surface area ("Surf. Area") were obtained from monthly, zonal mean profiles measured by SAGE II [Thomason et al., 1997 updated via private communication]. The profile of Be(y) is based on the Wamsley et al. relation with N2O, using MkIV measurements of N20O. All other model inputs given are based on direct MkIV measurements. Finally, we note the latitude of the MkIV tangent point varied considerably during sunrise on May 8, 1997. The simulations shown here were obtained using different latitudes for each altitude.

  18. Experimental dosimetry of Ho-166 bioglass seed polymer-protected

    International Nuclear Information System (INIS)

    Nogueira, Luciana B.; Campos, Tarcisio P.R.

    2011-01-01

    This study aims to develop experimental dosimetry of Ho-166 bio glass seed for brachytherapy studies using GAFCHROMIC EBT2 radio chromium films. The methodology consists of placement of radio chromium films in a compressed breast phantom, along with bio glass polymer-protected seeds of [Si: Ca: Ho] and [Si: Ca: Ho: Zr]. The bio glass seeds were encapsulated with polyvinyl alcohol, before being activated and used in the study. The bio glass seeds were introduced into the breast phantom, along with radio chromium films for a period of 2 hours. After the exposure time, radio chromium films were removed from phantom and digitized for analysis in ImageDIG 2.0 program, which quantifies the intensity of RGB (Red, Green, Blue). The dose calculation was evaluated by Monte Carlo technique. Experimental and theoretical data were used to calibrate the dose distribution. The results were plotted on graphs and dose iso curves were obtained. As conclusion it is possible to perform dosimetry in Ho-166 seed brachytherapy using radio chromium films, limited to a short exposure time and small activity. (author)

  19. Analysis of n+165Ho and 169Tm reactions

    International Nuclear Information System (INIS)

    Young, P.G.; Arthur, E.D.; Philis, C.; Nagel, P.; Collin, M.

    1982-09-01

    Experimental data for neutron-induced reactions on 165 Ho and 169 Tm have been theoretically analyzed in preparation for calculations on the unstable isotopes of Tm. A set of deformed optical model parameters was determined from measurements of s- and p-wave neutron strength functions, total cross sections, elastic angular distributions, and 16-MeV proton scattering to the 165 Ho ground and first excited states. The parameters for the 165 Ho and 169 Tm nuclei were linked by means of an isospin term in the real and imaginary well depths, together with adjustment of the ν 2 and ν 4 deformation parameters based on systematics in this mass region. Transmission coefficients from this analysis were used in Hauser-Feshbach statistical model calculations of the 169 Tm(n,ν) cross section as well as the 169 Tm(n,2n) and (n,3n) cross sections to 23 MeV, after application of suitable preequilibrium corrections. The results of these calculations are in good agreement with most of the available experimental data on 165 Ho and 169 Tm

  20. Development of Forest Drought Index and Forest Water Use Prediction in Gyeonggi Province, Korea Using High-Resolution Weather Research and Forecast Data and Localized JULES Land Surface Model

    Science.gov (United States)

    Lee, H.; Park, J.; Cho, S.; Lee, S. J.; Kim, H. S.

    2017-12-01

    Forest determines the amount of water available to low land ecosystems, which use the rest of water after evapotranspiration by forests. Substantial increase of drought, especially for seasonal drought, has occurred in Korea due to climate change, recently. To cope with this increasing crisis, it is necessary to predict the water use of forest. In our study, forest water use in the Gyeonggi Province in Korea was estimated using high-resolution (spatial and temporal) meteorological forecast data and localized Joint UK Land Environment Simulator (JULES) which is one of the widely used land surface models. The modeled estimation was used for developing forest drought index. The localization of the model was conducted by 1) refining the existing two tree plant functional types (coniferous and deciduous trees) into five (Quercus spp., other deciduous tree spp., Pinus spp., Larix spp., and other coniferous spp.), 2) correcting moderate resolution imaging spectroradiometer (MODIS) leaf area index (LAI) through data assimilation with in situ measured LAI, and 3) optimizing the unmeasured plant physiological parameters (e.g. leaf nitrogen contents, nitrogen distribution within canopy, light use efficiency) based on sensitivity analysis of model output values. The high-resolution (hourly and 810 × 810 m) National Center for AgroMeteorology-Land-Atmosphere Modeling Package (NCAM-LAMP) data were employed as meteorological input data in JULES. The plant functional types and soil texture of each grid cell in the same resolution with that of NCAM-LAMP was also used. The performance of the localized model in estimating forest water use was verified by comparison with the multi-year sapflow measurements and Eddy covariance data of Taehwa Mountain site. Our result can be used as referential information to estimate the forest water use change by the climate change. Moreover, the drought index can be used to foresee the drought condition and prepare to it.

  1. OH, HO2, and HO2* Radical Chemistry During PROPHET-AMOS 2016: Measurements and Model Comparison

    Science.gov (United States)

    Bottorff, B.; Lew, M.; Rickly, P.; Stevens, P. S.

    2017-12-01

    The hydroxyl (OH) and peroxy radicals, both the hydroperoxy radical (HO2) and organic peroxy radicals (RO2), play an important role in atmospheric chemistry. In addition to controlling lifetimes of many trace gases important to issues of global climate change, reactions of these radicals can also lead to the production of ozone and secondary organic aerosols in the atmosphere. Previous measurements of these radicals in remote forest environments have shown serious discrepancies with modeled concentrations. These results bring into question our understanding of the atmospheric chemistry of isoprene and other biogenic VOCs under low NOX conditions. In the summer of 2016, OH, HO2 and HO2* (HO2 + αRO2) radicals were measured using the Indiana University Laser-Induced Fluorescence Fluorescence Assay by Gas Expansion (LIF-FAGE) technique as part of the Program for Research on Oxidants: PHtochemistry, Emissions, and Transport- Atmospheric Measurements of Oxidants in Summer (PROPHET-AMOS). This campaign took place in a forested area in northern Michigan characterized by high mixing ratios of isoprene and low mixing ratios of NOX. Ambient measurements from this campaign will be compared to previous measurements at this site and to modeled predictions using both the Regional Atmospheric Chemistry Mechanism (RACM2) and the Master Chemical Mechanism. Potential interferences associated with the OH measurements will also be examined.

  2. Odhady absolutního kardiovaskulárního rizika v České republice

    Czech Academy of Sciences Publication Activity Database

    Reissigová, Jindra; Zvárová, Jana

    2008-01-01

    Roč. 88, č. 5 (2008), s. 288-292 ISSN 0032-6739 Institutional research plan: CEZ:AV0Z10300504 Keywords : framinghamská studie * SCORE studie * odhad kardiovaskulárního rizika * validační studie Subject RIV: BB - Applied Statistics, Operational Research

  3. Isolation of {sup 163}Ho from dysprosium target material by HPLC for neutrino mass measurements

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Veronika; Taylor, Wayne A.; Nortier, Francois M.; Engle, Jonathan W.; Pollington, Anthony D.; Kunde, Gerd J.; Rabin, Michael W.; Birnbaum, Eva R. [Los Alamos National Laboratory, Los Alamos, NM (United States). Chemistry Div.; Barnhart, Todd E.; Nickles, Robert J. [Univ. Wisconsinn, Madison, WI (United States). Dept. of Medical Physics

    2015-07-01

    The rare earth isotope {sup 163}Ho is of interest for neutrino mass measurements. This report describes the isolation of {sup 163}Ho from a proton-irradiated dysprosium target and its purification. A Dy metal target was irradiated with 16 MeV protons for 10 h. After target dissolution, {sup 163}Ho was separated from the bulk Dy via cation-exchange high performance liquid chromatography using 70 mmol dm{sup -3} α-hydroxyisobutyric acid as the mobile phase. Subsequent purification of the collected Ho fraction was performed to remove the α-hydroxyisobutyrate chelating agent and to concentrate the Ho in a low ionic strength aqueous matrix. The final solution was characterized by MC-ICP-MS to determine the {sup 163}Ho/{sup 165}Ho ratio, {sup 163}Ho and the residual Dy content. The HPLC purification process resulted in a decontamination factor 1.4 x 10{sup 5} for Dy. The isolated Ho fraction contained 24.8 ± 1.3 ng of {sup 163}Ho corresponding to holmium recovery of 72 ± 3%.

  4. Comparing particles for radiosynovectomy labeled with Ho-166

    International Nuclear Information System (INIS)

    Argueelles, M.G.; Luppi Berlanga, I.S.; Torres, E.A.; Pereyra Molina, V.

    2002-01-01

    Aim: Three types of microparticles containing Ho-166 were investigated as potential agents for radiation synovectomy. These are: hydroxyapatite (HA), ferric hydroxide macro-aggregates (FHMA) and polymeric micro-spheres (PM). Labeling was performed by three different methods: coprecipitation, two steps labeling using citrate and irradiation of Ho-165 complexed to acetylacetone (AcAc) incorporated into poly-L-lactic acid spheres (PLA) by the solvent evaporation technique. Material and methods: a coprecipitation technique of holmium hydroxide and ferric hydroxide was used in order to obtain 166 Ho-FHMA. Particle size was determined by optical microscopy and selective filtration (1.2 - 100 μm). Obtainment efficiency of FHMA was always higher than 90%. Radiochemical purity was checked by thin layer chromatography using ITLC/SG and EDTA solution as solvent. In vitro stability studies were performed by incubating labelled particles in either saline, or EDTA solution. Hydroxyapatite particles were prepared from the reaction of calcium nitrate and ammonia phosphate at high pH. By strong heating of the precipitate at 800 0 C, the product becomes largely anhydrous and hardened. The yield of the hydroxyapatite synthesis was always greater than 80%. Particle size range was studied using light microscopy. Labeling was done in two steps: 166Ho-citrate was prepared by adding sufficient citric acid to the 166 Ho-Cl 3 solution. The radioactive solution was added to the particulate suspension stirring continuously. Radiolabelled particles were rinsed and separated by centrifugation. Stable Ho-165, complexed to acetylacetone (AcAc), was incorporated into PLA spheres by the solvent evaporation technique. The particle size distribution of the micro-spheres was determined by electronic microscopy. A X-ray fluorescence technique was used to determine the percentage of 165 Ho-AcAc incorporated in the microspheres by studying standards and prepared PLA spheres. Stability studies were

  5. Ho:YLF & Ho:LuLF slab amplifier system delivering 200 mJ, 2 µm single-frequency pulses

    CSIR Research Space (South Africa)

    Strauss, HJ

    2011-07-01

    Full Text Available A single-frequency single-pass amplifier based on Ho:YLF and Ho:LuLF in a scalable slab architecture delivering up to 210 mJ at 2064 nm is demonstrated. The amplifier was end-pumped by a 1890 nm Tm:YLF slab laser and was seeded with a 69 mJ single...

  6. Návrh slaďování pracovního a soukromého života ve vybrané organizaci

    OpenAIRE

    Majerčíková, Andrea

    2014-01-01

    Cílem diplomové práce je analyzovat strategii vybrané soukromé organizace v oblasti slaďování pracovního a osobního života a navrhnout opatření ke zlepšení stávajícího stavu. Práce specifikuje pojmy jako konflikt rolí v rámci pracovního a osobního života, gender a politika rovných příležitostí, koncept „flexicurity“ a dále nastiňuje různorodá opatření napomáhající slaďování pracovního a soukromého života. V rámci analýzy bylo využito dotazníkového šetření a rozhovoru s manažerkou vybrané orga...

  7. Optical characteristics of BaGa2S4:Ho3+ and BaGa2Se4:Ho3+ single crystals

    International Nuclear Information System (INIS)

    Choe, Sung-Hyu; Jin, Moon-Seog; Kim, Wha-Tek

    2005-01-01

    BaGa 2 S 4 , BaGa 2 S 4 :Ho 3+ , BaGa 2 Se 4 , and BaGa 2 Se 4 :Ho 3+ single crystals were grown by using the chemical transport reaction method. The optical energy gaps of the single crystals were investigated in the temperature region from 11 K to 300 K. The temperature dependence of the optical energy gap was well fitted by the Varshni equation. Two broad emission bands were observed in the photoluminescence spectra of the single crystals. These bands were attributed to donor-acceptor pair recombinations. Sharp emission peaks were observed in the BaGa 2 S 4 :Ho 3+ and the BaGa 2 Se 4 :Ho 3+ single crystals and were assigned to radiation recombination between split Stark levels of Ho 3+ .

  8. Upconversion dynamics in Yb3+-Ho3+-doped fluoroindate glasses

    International Nuclear Information System (INIS)

    Martin, I.R.; Rodriguez, V.D.; Lavin, V.; Rodriguez-Mendoza, U.R.

    1998-01-01

    The mechanisms and dynamics of the upconversion emissions in Yb 3+ -Ho 3+ -doped fluoroindate glasses by exciting at 975 nm have been analysed. The upconversion efficiencies have been measured as a function of temperature in the range from 12 to 295 K. The temporal evolution of the 545- and 650-nm upconversion emissions obtained under flash excitation at 975 nm in codoped samples with 2.25 mol.% of Yb 3+ and 0.75 mol.% of Ho 3+ cannot be described using the energy migration model. This indicates that at this concentration of Yb 3+ the rapid migration regimen between these ions has not been reached. A model is proposed in order to explain the temporal evolution of these emissions taking into account energy migration between donors and backtransfer processes. (orig.)

  9. Polarized neutron capture in polarized 59Co and 165Ho nuclei

    International Nuclear Information System (INIS)

    Bosman, J.J.

    1976-01-01

    Gamma spectroscopy on the reactions 59 Co(n,γ) 60 Co and 165 Ho(n,γ) 166 Ho with polarized neutrons and polarized targets enabled the assignment of spins to 36 levels in 60 Co and 15 levels in 166 Ho. Several of them had not been reported earlier. The techniques used to polarize neutron beams and targets and the gamma-spectroscopy are extensively discussed

  10. Spectroscopic analysis of LiHoF4 and LiErF4

    DEFF Research Database (Denmark)

    Christensen, H.P.

    1979-01-01

    The polarized absorption spectra for Ho3+ and Er3+ in LiHoF4 and LiErF4, respectively, have been recorded in the spectral interval 4000-26 000 cm-1 at 2 K. Parts of the spectra were examined at higher temperatures. The experimental levels for Ho3+ and Er3+ in LiRF4 were close to those found in Li...

  11. HoTbTi2O7, the mixtures of spin ice and spin liquid

    International Nuclear Information System (INIS)

    Chang, L.J.; Terashita, H.; Schweika, W.; Chen, Y.Y.; Gardner, J.S.

    2007-01-01

    Polycrystalline samples of Ho 2- x Tb x Ti 2 O 7 (x=0.5, 1, and 1.5) have been prepared and characterized. No long-range order is observed for HoTbTi 2 O 7 in magnetization and specific heat measurements down to 2 K. The low-energy magnetic excitation measurements suggests that HoTbTi 2 O 7 possesses both characteristics of spin ice and spin liquid in the ground state

  12. Insights into the photochemical transformation pathways of triclosan and 2′-HO-BDE-28

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ya-nan; Xie, Qing; Chen, Jingwen, E-mail: jwchen@dlut.edu.cn; Li, Yingjie; Fu, Zhiqiang

    2015-12-30

    Highlights: • Direct photolysis of anionic HO-PXDEs occurs through excited singlet states. • Dioxin products are formed from excited singlet states of HO-PXDEs. • Self-sensitized photolysis is involved in the phototransformation of HO-PXDEs. • {sup 1} O{sub 2} and ·OH can be generated in energy or electron transfer reactions between excited HO-PXDEs and dissolved O{sub 2}. - Abstract: Hydroxylated polyhalogenated diphenyl ethers (HO-PXDEs) have been recognized as a group of widely detected emerging contaminants in natural waters. Photolysis was proved to be an important transformation pathway for these compounds and their direct phototransformation results in highly toxic dioxins. However, the roles of excited states and reactive oxygen species in the photochemical transformation of these compounds are still unclear. In this study, 2′-HO-2,4,4′-trichlorodiphenyl ether (triclosan) and 2′-HO-2,4,4′-tribromodiphenyl ether (2′-HO-BDE-28) were selected as model compounds to investigate their phototransformation processes. Results showed that the direct photolysis reactions of both triclosan and 2′-HO-BDE-28 occurred via their respective excited singlet states, leading to the generation of dioxins. In addition, the energy and electron transfer reactions between excited states of model compounds and molecular O{sub 2} can lead to the generation of {sup 1}O{sub 2} and ·OH, which results in self-sensitized photolysis. We also found that both the k, Φ dioxin yield for anionic triclosan were higher than those of anionic 2′-HO-BDE-28. This study revealed the roles of the excited states in direct photolysis and the generation pathway of reactive oxygen species in self-sensitized photolysis of HO-PXDEs, which is important for understanding the phototransformation mechanisms of HO-PXDEs.

  13. Consumer Behaviour. Case: iPhone Ho Chi Minh City

    OpenAIRE

    Tran, Thi Xuan Oanh

    2016-01-01

    The main aim of this thesis is to figure out the factors that have influenced consumer behaviour of young iPhone users in Ho Chi Minh City. In this study, the author draw a conclusion based on the data collected from the survey and proposed some feasible recommendations for Apple and other high-end smartphone companies to understand their consumers and enhance brand equity. For the secondary data, a variety of theories, including consumers’ characteristics, promotion and the decision mak...

  14. Identical gamma-vibrational bands in {sup 165}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Radford, D.C.; Galindo-Uribarri, A.; Janzen, V.P. [Chalk River Labs., Ontario (Canada)] [and others

    1996-12-31

    The structure of {sup 165}Ho at moderate spins has been investigated by means of Coulomb excitation. Two {gamma}-vibrational bands (K{sup {pi}} = 11/2{sup {minus}} and K{sup {pi}} = 3/2{sup {minus}}) are observed, with very nearly identical in-band {gamma}-ray energies. Gamma-ray branching ratios are analyzed to extract information on Coriolis mixing, and the role of the K quantum number in identical bands is discussed.

  15. Temperature Variation of the Magnetic Structure of HoSb

    DEFF Research Database (Denmark)

    Andersen, Nils Axel; Kjems, Jørgen; Vogt, O.

    1980-01-01

    Neutron diffraction has been used to show that the magnetic moment vector in the antiferromagnet HoSb changes direction as a function of temperature below TN=5.7K. The experimental results are in qualitative agreement with a recent theoretical prediction by Jensen et al. (1980) which ascribe the ...... the changing directions to a competition between the crystal fields and the dipolar interactions....

  16. Spectroscopic characterization of Ho3+ ion-doped fluoride glass

    International Nuclear Information System (INIS)

    Florez, A.; Oliveira, S.L.; Florez, M.; Gomez, L.A.; Nunes, L.A.O.

    2006-01-01

    Among the new optical materials available, fluoride glass, which has an extended transmission window, is emerging as an important material for use in optical fibers, lasers, sensors, etc. Here, we analyze the spectroscopic properties of Ho 3+ ions in a fluoroindate glass based on absorption measurements. Ho 3+ -doped fluoroindate glass with the composition (40 - x)InF 3 -20SrF 2 -20ZnF 2 -16BaF 2 -2GdF 3 -2NaF-xHoF 3 , x = 1.0, 2.0, 2.5, 3.0, 4.0, 5.0, 6.0, 8.0 and 9.0 mol%, was prepared under an argon atmosphere. Absorption spectra in the range 300-2200 nm were then obtained. The experimental oscillator strength f Exp. was calculated from the areas under absorption bands. Using Judd-Ofelt theory and least-squares fitting, the phenomenological intensity parameter Ω λ (λ = 2, 4, 6) and the theoretical oscillator strength f Cal. were calculated. To evaluate potential applications and to analyze the properties of Ho 3+ ions in these host glasses, the following spectroscopy parameters were calculated: the transition probability between multiplets A JJ' , the branching ratio β JJ' , the radiative lifetime τ R , the peak cross-section for stimulated emission σ p , and the emitting-level multiphonon rate W NR for each band. The results were compared with those reported in the literature for similar glasses of the same concentration

  17. Separation and implantation of the rare isotope {sup 163}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Kieck, Tom; Chrysalidis, Katerina; Dorrer, Holger; Kormannshaus, Stefan; Schmidt, Sebastian; Schneider, Fabian; Wendt, Klaus [JGU Mainz (Germany); Duellmann, Christoph [JGU Mainz (Germany); GSI Darmstadt (Germany); Gamer, Lisa; Gastaldo, Loredana [Universitaet Heidelberg (Germany); Collaboration: ECHo-Collaboration

    2016-07-01

    The ECHo collaboration aims at measuring the electron neutrino mass by recording the spectrum following electron capture of {sup 163}Ho. To reach a sub-eV sensitivity, a large number of individual microcalorimeters is needed, into which the isotope must be implanted in a well-controlled manner. The necessary amount of {sup 163}Ho is produced by neutron irradiation of enriched {sup 162}Er in the ILL high flux reactor. This introduces significant contaminations of other radioisotopes, which have to be quantitatively removed both, by chemical and mass spectrometric separation. The application of resonance ionization at the RISIKO mass separator guarantees the required isotope selectivity for purification and suitable energy for ion implantation. The efficiency and stability of the laser ion source was improved by Finite-Element Analysis of the thermal processes. For optimum implantation into the detector pixels (170 x 170 μm{sup 2}) with minimum losses a small ion beam spot at the implantation site is needed. For this purpose, post focusing ion optics were installed. Simulations were performed in order to optimize the homogeneous distribution of the implanted ions. The necessity to alternate implantation phases with deposition of a thin metallic layer for {sup 163}Ho activities larger than 10 Bq is being discussed.

  18. Diode laser-pumped Ho:YLF laser

    International Nuclear Information System (INIS)

    Hemmati, H.

    1987-01-01

    The author reports laser action in Ho:YLF at 2.06 μm following optical pumping with a cw diode laser array. Diode laser-pumped Nd-YAG and Ho:YAG have been reported recently. Lasers with a wavelength of 2 μm have medical and optical communication applications. The diode laser light is focused with a 60-mm focal length lens onto the YLF crystal. A high-reflectivity mirror with 100-mm radius of curvature was used as the output coupler. The lasing threshold was at 5 mWof incident power. This is higher than expected considering that a high reflector was used as the output coupler. However, a more uniform cooling of the crystal is expected to lower the lasing threshold. With 100 mW of pump power coupled into the crystal, --20 mW of 2-μm radiation was observed from this unoptimized setup. The 2-μm laser output is highly sensitive to output coupler alignment, YLF crystal temperature, and pump laser wavelength. The 20% optical conversion efficiency achieved in his preliminary measurements is expected to be improved by better crystal cooling, proper matching of laser wavelength to crystal absorption, variations in the concentration of Ho and sensitizers and use of a proper output coupler. A study of the parameters mentioned above and the effect of crystal temperature on the laser output is under way

  19. Automatizace domácího mikropivovaru

    OpenAIRE

    Širůček, Pavel

    2015-01-01

    Práce pojednává o základech technologie výroby piva a surovinách pro výrobu piva potřebných, domácích mikropivovarech, základních postupech a principech užívaných v těchto pivovarech a jejich použití. Dále se věnuje konkrétnímu řešení zvoleného mikropivovaru, jeho návrhu, sestavení a automatizaci, včetně popisu řídícího softwaru. Zvolený mikropivovar je troj nádobový, k ohřevu je použit plynový hořák a přečerpávání zajišťuje čerpadlo. Jako řídící jednotka slouží programovatelný automat PLC LO...

  20. Návrh a implementace internetového obchodu

    OpenAIRE

    Maťák, Lubomír

    2010-01-01

    Obsahem této práce je analýza a návrh elektronického obchodu pro firmu, zabývající se velkoobchodním prodejem elektromateriálu a poskytování služeb v oblasti dodávek elektromateriálu na stavbu různých projektů, jak ze státního, tak ze soukromého sektoru. Nejedná se o klasický internetový obchod formou B2C. Koncept této práce je navržen jako B2B. Hlavní myšlenkou je online komunikace dodavatele a odběratele a možná kontrola, jak stavu zakázky, tak stavu skladu pro případné další objednávky. ...

  1. Fluctuations in a Hořava-Lifshitz bouncing cosmology

    International Nuclear Information System (INIS)

    Gao, Xian; Wang, Yi; Xue, Wei; Brandenberger, Robert

    2010-01-01

    Hořava-Lifshitz gravity is a potentially UV complete theory with important implications for the very early universe. In particular, in the presence of spatial curvature it is possible to obtain a non-singular bouncing cosmology. The bounce is realized as a consequence of higher order spatial curvature terms in the gravitational action. Here, we extend the study of linear cosmological perturbations in Hořava-Lifshitz gravity coupled to matter in the case when spatial curvature is present. As in the case without spatial curvature, we find that there is no extra dynamical degree of freedom for scalar metric perturbations. We study the evolution of fluctuations through the bounce and show that the solutions remain non-singular throughout. If we start with quantum vacuum fluctuations on sub-Hubble scales in the contracting phase, and if the contracting phase is dominated by pressure-less matter, then for λ = 1 and in the infrared limit the perturbations at late times are scale invariant. Thus, Hořava-Lifshitz gravity can provide a realization of the ''matter bounce'' scenario of structure formation

  2. Model elektronického obchodu pro služby

    OpenAIRE

    Zechmeisterová, Věra

    2009-01-01

    Obsahem práce je vytvoření modelu informačního zabezpečení služeb autoopravny a vytvoření odpovídajícího systémového řešení elektronického obchodování této autoopravny. The content of this Master thesis is the creation of the car repair shop services informational security model and also the creation of commensurate e-commerce system solution for this car repair shop. A

  3. Diode-Pumped Thulium (Tm)/Holmium (Ho) Composite Fiber 2.1-Micrometers Laser

    Science.gov (United States)

    2015-09-01

    Schematic of the 800-nm diode pumped Tm/Ho composite fiber laser 8 Under quasi-continuous wave (Q- CW ) pumping conditions of 1-ms duration and a...Fig. 9 (Top) Schematic of the 800-nm diode -pumped Tm/Ho composite fiber laser with outcoupler. (Left) Q- CW laser performance of the Tm/Ho composite...ARL-TR-7452 ● SEP 2015 US Army Research Laboratory Diode -Pumped Thulium (Tm)/Holmium (Ho) Composite Fiber 2.1-μm Laser by G

  4. The mass of the electron neutrino and electron capture in 163Ho

    International Nuclear Information System (INIS)

    Yasumi, S.; Rajasekaran, G.; Ando, M.; Ochiai, F.; Ikeda, H.; Ohta, T.; Stefan, P.M.; Maruyama, M.; Nashimoto, N.; Fujioka, M.; Ishii, K.; Shinozuka, T.; Sera, K.; Omori, T.; Izawa, G.; Yagi, M.; Masumoto, K.; Shima, K.

    1983-01-01

    To determine the mass of the electron neutrino, electron capture in 163 Ho was studied. From the intensity of M X-rays and the total number of 163 Ho atoms in a source, as determined by the PIXE method, the partial M-capture half life of 163 Ho was estimated to be (4.5 +- 1.5) x 10 4 yr. A relation between the Q-value of 163 Ho and the mass of the electron neutrino was obtained. (orig.)

  5. [hHO-1 structure prediction and its mutant construct, expression, purification and activity analysis].

    Science.gov (United States)

    Xia, Zhen Wei; Cui, Wen Jun; Zhou, Wen Pu; Zhang, Xue Hong; Shen, Qing Xiang; Li, Yun Zhu; Yu, Shan Chang

    2004-10-01

    Human Heme Oxygenase-1 (hHO-1) is the rate-limiting enzyme in the catabolism reaction of heme, which directly regulates the concentration of bilirubin in human body. The mutant structure was simulated by Swiss-pdbviewer procedure, which showed that the structure of active pocket was changed distinctly after Ala25 substituted for His25 in active domain, but the mutated enzyme still binded with heme. On the basis of the results, the expression vectors, pBHO-1 and pBHO-1(M), were constructed, induced by IPTG and expressed in E. coli DH5alpha strain. The expression products were purified with 30%-60% saturation (NH4)2SO4 and Q-Sepharose Fast Flow column chromatography. The concentration of hHO-1 in 30%-60% saturation (NH4)2SO4 components and in fractions through twice column chromatography was 3.6-fold and 30-fold higher than that in initial product, respectively. The activity of wild hHO-1 (whHO-1) and mutant hHO-1 (deltahHO-1) showed that the activity of deltahHO-1 was reduced 91.21% compared with that of whHO-1. The study shows that His25 is of importance for the mechanism of hHO-1, and provides the possibility for effectively regulating the activity to exert biological function.

  6. The effect of Ho to the flux pinning and microstructure of powder melting process Y(Ho)BCO samples

    International Nuclear Information System (INIS)

    Liu Peng; Chao Xixu; Shi Zhiqiang; Zhao Zhongxiang

    1994-01-01

    Magnetic relaxation and magnetization are measured for powder melting Y 1-x Ho x Ba 2 Cu 3 O 7 (x = 0.2, 0.4, and 0.6) samples within a wide temperature range. The pinning potential U and magnetization critical current densities J c are obtained according to the theory of Anderson and Kim and Bean's model. It is found that both U and J c are a affected by the addition of the rare-earth element Ho. In the sample with x = 0.4 the pinning potential U and the critical current J c have maximum values when the magnetic field is parallel to the c-axis. An unusual behaviour of U as a function of temperature T, which may be related to the pinning potential distribution in the sample is observed. (orig.)

  7. Fine Structure in Proton Emission from the Deformed 141g.sHo and 141mHo

    International Nuclear Information System (INIS)

    Karny, M.; Rykaczewski, Krzysztof Piotr; Grzywacz, R.; Batchelder, J.C.; Bingham, C.R.; Goodin, C. T.; Gross, Carl J.; Hamilton, J.H.; Korgul, A.; Krolas, W.; Liddick, S. N.; Li, K.; Maier, Karl; Mazzocchi, C.; Piechaczek, A.; Shapira, Dan; Simpson, D.; Tantawy, M.N.; Winger, J.A.; Yu, Chang-Hong; Zganjar, E. F.

    2007-01-01

    Fine structure in proton emission from the deformed states 141g.s Ho (T 1/2 = 4.1 ms) and 141 mHo (T 1/2 = 7.4 (micro)s) has been discovered at Oak Ridge by detecting fusion evaporation residues with the Recoil Mass Spectrometer, Si-detectors and digital signal processing electronics. The branching ratios to the first 2 + excited state in 140 Dy were measured to be I p g.s. (2 + ) = 0.9±0.1% and I p m (2 + ) = 1.7±0.5%. A comparison of the available calculations to the experimental values calls for further development of the theoretical models

  8. Návrh podnikatelského plánu pro vznik a rozvoj vybraného podniku

    OpenAIRE

    Kropáček, Lukáš

    2014-01-01

    Hlavním cílem předkládané absolventské práce je vytvořit návrh podnikatelského záměru pro vznik a další rozvoj minipivovaru. The main goal of the thesis is to propose a business plan for establishment and development of a microbrewery. A

  9. Extratumoral Heme Oxygenase-1 (HO-1 Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth.

    Directory of Open Access Journals (Sweden)

    Sofia Halin Bergström

    Full Text Available Aggressive tumors induce tumor-supporting changes in the benign parts of the prostate. One factor that has increased expression outside prostate tumors is hemoxygenase-1 (HO-1. To investigate HO-1 expression in more detail, we analyzed samples of tumor tissue and peritumoral normal prostate tissue from rats carrying cancers with different metastatic capacity, and human prostate cancer tissue samples from primary tumors and bone metastases. In rat prostate tumor samples, immunohistochemistry and quantitative RT-PCR showed that the main site of HO-1 synthesis was HO-1+ macrophages that accumulated in the tumor-bearing organ, and at the tumor-invasive front. Small metastatic tumors were considerably more effective in attracting HO-1+ macrophages than larger non-metastatic ones. In clinical samples, accumulation of HO-1+ macrophages was seen at the tumor invasive front, almost exclusively in high-grade tumors, and it correlated with the presence of bone metastases. HO-1+ macrophages, located at the tumor invasive front, were more abundant in bone metastases than in primary tumors. HO-1 expression in bone metastases was variable, and positively correlated with the expression of macrophage markers but negatively correlated with androgen receptor expression, suggesting that elevated HO-1 could be a marker for a subgroup of bone metastases. Together with another recent observation showing that selective knockout of HO-1 in macrophages reduced prostate tumor growth and metastatic capacity in animals, the results of this study suggest that extratumoral HO-1+ macrophages may have an important role in prostate cancer.

  10. Neutron diffraction studies of Ho1-xYxNi2B2C compounds

    DEFF Research Database (Denmark)

    Chang, L.J.; Tomy, C.V.; Paul, D.M.K.

    1996-01-01

    Neutron diffraction measurements have been carried out to investigate the nature of magnetic ordering in Ho(1-x)Y(x)Ni(2)B(2)C (x = 0, 0.1 and 0.2) compounds. HoNi(2)B(2)C shows a complex type of magnetic ordering below the superconducting transition, with a commensurate antiferromagnetic ordering...

  11. Ozone decomposition in water studied by pulse radiolysis. 2. OH and HO4 as chain intermediates

    International Nuclear Information System (INIS)

    Staehelin, J.; Buehler, R.E.; Hoigne, J.

    1984-01-01

    Ozone decomposition in pure water involves a chain mechanism, initiated by the reaction OH - +O 3 and propogated by O 2 - and OH. In the present studies this chain is initiated by pulse radiolysis of aqueous solutions of ozone. The chain propogation steps were studied in two parts. By computer simulation of the rate curves, it is shown that from OH + O 3 and intermediate HO 4 must be formed, most likely a charge-transfer complex (HO.O 3 ), which eventually decays into HO 2 . The derived rate constants for the formation of the various species are included. The spectrum of HO 4 is derived. It is similar to the one of ozone, but the absorption coefficients are about 50% larger. In the presence of high ozone concentration, the dominant chain termination reactions are HO 4 + HO 4 and HO 4 + HO 3 . The effect on chain length, dose, overall rate, and pH and of added scavengers is described. The implications for the natural ozone decay mechanism are discussed

  12. HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.

    Science.gov (United States)

    Zukor, Hillel; Song, Wei; Liberman, Adrienne; Mui, Jeannie; Vali, Hojatollah; Fillebeen, Carine; Pantopoulos, Kostas; Wu, Ting-Di; Guerquin-Kern, Jean-Luc; Schipper, Hyman M

    2009-05-01

    Oxidative stress, deposition of non-transferrin iron, and mitochondrial insufficiency occur in the brains of patients with Alzheimer disease (AD) and Parkinson disease (PD). We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of non-transferrin iron in astroglial mitochondria. Herein, dynamic secondary ion mass spectrometry (SIMS) and other techniques were employed to ascertain (i) the impact of HO-1 over-expression on astroglial mitochondrial morphology in vitro, (ii) the topography of aberrant iron sequestration in astrocytes over-expressing HO-1, and (iii) the role of iron regulatory proteins (IRP) in HO-1-mediated iron deposition. Astroglial hHO-1 over-expression induced cytoplasmic vacuolation, mitochondrial membrane damage, and macroautophagy. HO-1 promoted trapping of redox-active iron and sulfur within many cytopathological profiles without impacting ferroportin, transferrin receptor, ferritin, and IRP2 protein levels or IRP1 activity. Thus, HO-1 activity promotes mitochondrial macroautophagy and sequestration of redox-active iron in astroglia independently of classical iron mobilization pathways. Glial HO-1 may be a rational therapeutic target in AD, PD, and other human CNS conditions characterized by the unregulated deposition of brain iron.

  13. Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement.

    Science.gov (United States)

    Zeng, Bin; Ren, Xiaofeng; Lin, Guosheng; Zhu, Chengang; Chen, Honglei; Yin, Jiechao; Jiang, Hong; Yang, Bo; Ding, Danhua

    2008-10-01

    The aim has been to determine whether the supernatants of mesenchymal stem cells (MSCs) transfected with adenovirus carrying human heme oxygenase-1 (hHO-1) gene protect cardiomyocytes from ischemic injury. We have found that hHO-1 infected MSCs (hHO-1-MSCs) increased expression of hHO-1 protein. Apoptosis of cultured hHO-1-MSCs exposed to hypoxia was suppressed. Several cytokines, including HGF, bFGF, TGF-beta, VEGF and IL-1beta, were produced by hHO-1-MSCs, some being significantly enhanced under hypoxia stimulation. Meanwhile, those cytokines reduced caspase-3 level and activity in cultured adult rat ventricular cardiomyocytes (ARVCs) exposed to hypoxia. Supernatants obtained from hHO-1-MSCs improved left ventricular function, limited myocardial infarct size, increased microvessel density, and inhibited apoptosis of cardiomyocytes in rat myocardial infarction. It can be concluded hHO-1-modified MSCs prevent myocardial cell injury via secretion of paracrine-acting mediators.

  14. Efficient Ho:YLF laser pumped by a Tm:fiber laser

    CSIR Research Space (South Africa)

    Koen, W

    2013-10-01

    Full Text Available A thulium fiber laser pumped Ho:YLF laser delivering 45.1 W in a near diffraction limited beam when pumped with 84.7 W is demonstrated. The optical-to-optical efficiency of 53 % compares favorably with similar Ho:YAG lasers....

  15. Q-switched Ho:YLF laser pumped by a Tm:GdVO4 laser.

    CSIR Research Space (South Africa)

    Esser, MJD

    2009-06-01

    Full Text Available The authors have, through careful analysis of spectroscopic data, designed and demonstrated a diode-end-pumped, quasicontinuous wave Tm:GdVO4 laser operating at 1892 nm in order to pump a Q-switched Ho:YLF laser. The Ho:YLF maximum output energy...

  16. Experimental Investigation of Phase Equilibria in the Ho-Ti-Si Ternary System at 973 K (700 °C)

    Science.gov (United States)

    Han, Feng; Zhan, Yongzhong

    2018-02-01

    Phase equilibrium relations of the Ho-Ti-Si ternary system at 973 K (700 °C) were experimentally researched by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectrometer (EDS). The isothermal section of the system at 973 K (700 °C) consists of 14 three-phase regions, 27 two-phase regions, and 14 single-phase regions. The phases Ti5Si3, Ti5Si4, TiSi, TiSi2, Ho5Si3, Ho5Si4, HoSi, αHoSi2-b, and βHoSi2-a are proved to exist at 973 K (700 °C). Previously reported HoTiSi and Ho2Ti3Si4 ternary compounds were confirmed to exist at this temperature. The solubility of Ho in the intermediate phases (i.e., TiSi2, TiSi, Ti5Si4, and Ti5Si3) at the Ti-Si side is extremely small. The maximum solubilities of Ti in HoSi2-b, Ho5Si4, and Ho5Si3 are confirmed to be 8.0, 7.2, and 6.0 at. pct, respectively.

  17. Magnetic Resonance Imaging-Based Radiation-Absorbed Dose Estimation of Ho-166 Microspheres in Liver Radioembolization

    NARCIS (Netherlands)

    Seevinck, Peter R.; van de Maat, Gerrit H.; de Wit, Tim C.; Vente, Maarten A. D.; Nijsen, Johannes F. W.; Bakker, Chris J. G.

    2012-01-01

    Purpose: To investigate the potential of magnetic resonance imaging (MRI) for accurate assessment of the three-dimensional Ho-166 activity distribution to estimate radiation-absorbed dose distributions in Ho-166-loaded poly (L-lactic acid) microsphere (Ho-166-PLLA-MS) liver radioembolization.

  18. His Excellency Professor Dr Che-Ho Wei, Chairman, National Science Council Executive Yuan, Republic of China

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: Professor Dr. Che-Ho Wei signing the Guest Book with CERN Director-General, L. Maiani. Photo 02: Professor Dr. Che-Ho Wei. Photo 03::Professor Dr. Che-Ho Wei shaking hands with CERN Director-General, L. Maiani.

  19. Marketingový mix výrobního družstva IRISA

    OpenAIRE

    Nguyen, Anh Duc

    2016-01-01

    Tato bakalářská práce je zaměřena marketing a konkrétně na marketingový mix produktů. V teoretické části vysvětlím základní pojmy marketingu a marketingového mixu. V analytické části provedu analýzy marketingového mixu vybraného podniku. V návrhové části sestavím návrhy na změny současného marketingového mixu. This thesis is focused specifically on marketing and marketing mix of products. The theoretical part explains the basic concepts of marketing and marketing mix. The analytical part w...

  20. Superdeformation studies in {sup 150}Tb and {sup 153}Ho

    Energy Technology Data Exchange (ETDEWEB)

    Nisius, D.; Janssens, R.V.F.; Crowell, B. [and others

    1995-08-01

    There are now over 40 superdeformed (SD) bands known in the A {approximately} 150 region and in most cases the properties of these bands are understood in terms of single-particle excitations in the absence of pairing. By continuing the search for new SD bands we hope to gain insight into (1) the ordering of the proton and neutron orbitals near the Fermi surface in the SD well, (2) the effects that the alignment of those orbitals has on the moments of inertia, and (3) the collective excitations in the SD well. For {sup 150}Tb, which is one proton and one neutron away from the SD doubly-magic nucleus {sup 152}Dy, it should be possible to study SD bands based on both proton and neutron hole excitations. By adding one proton to the {sup 152}Dy nucleus (i.e. {sup 153}Ho) proton excitations above the Z = 66 shell gap can be studied. These excitations are important as calculations suggested that the proton intruder orbital N = 7 might become occupied. Interactions between this orbital and a N = 5 level may result in softness towards octupole vibrations. High spin states in {sup 150}Th and {sup 153}Ho were populated using the {sup 124}Sn({sup 31}P,5n) and {sup 120}Sn({sup 37}Cl,4n) reactions, respectively. In both cases the early implementation phase of Gammasphere was used to detect the decay gamma rays and over 1 x 10{sup 9} triple and higher fold coincidence events were recorded. In {sup 150}Tb, the data analysis is complete and two new SD bands were identified. The fact that Im{sup (2)} moments of inertia are sensitive to the specific high-N intruder content of the SD bands was used to suggest configurations for the two new bands. A paper reporting these results is being prepared. For {sup 153}Ho, data analysis is still in its early stages.

  1. Dy163-Ho163 branching: an s-process barometer

    International Nuclear Information System (INIS)

    Beer, H.; Walter, G.; Macklin, R.L.

    1984-01-01

    The neutron capture cross sections of Dy163 and Er164 have been measured to analyze the s-process branching at Dy163-Ho163. The reproduction of the s-process abundance of Er164 via this branching is sensitive to temperature kT, neutron density, and electron density n/sub e/. The calculations using information from other branchings on kT and the neutron density n/sub n/ give constraints for n/sub e/ at the site of the s-process

  2. The complexes of Ho with methylenediphosphonate and 1 hydroxyethylidenephosphonate

    International Nuclear Information System (INIS)

    Vanura, P.; Jedinakova-Krizova, V.; Hakenova, L.; Munesawa, Y.

    1999-01-01

    The composition and stability of holmium methylenediphosphonate (MDP) and 1-hydroxyethylidenephosphonate (HEDP) complexes in the aqueous solution of 0.1 M NaCl at the temperature of 25 grad C were studied by potentiometric titration methods. The complexes of the composition HoH n L have been found in the aqueous solution if the concentration of the ligand is higher than the concentration of holmium. The protonation constants of both acids and stability constants of all complexes were determined and the comparison with literature data of analogical complexes of other lanthanides was performed. (authors)

  3. Ultra-violet emission in Ho:ZBLAN fiber

    International Nuclear Information System (INIS)

    Kowalska, M.; Klocek, G.; Piramidowicz, R.; Malinowski, M.

    2004-01-01

    We report on the short wavelength (green, blue, and ultra-violet (UV)) emission in trivalent holmium doped fluoro-zirconate fiber (Ho 3+ :ZBLAN) under direct and upconversion pumping. Efficient red to UV upconversion has been observed using 647 nm cw pumping by krypton ion laser. A close to cubic UV signal intensity dependence on incident red pump power was determined, confirming the three-photon character of the observed process. The responsible upconversion mechanisms were investigated and shown to be excited state absorption (ESA) via low-lying 5 I 7 and 5 I 6 sates. Dynamics of the involved excited states have been studied under pulsed laser excitation

  4. Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.

    Science.gov (United States)

    Liu, Xiaoli; Pachori, Alok S; Ward, Christopher A; Davis, J Paul; Gnecchi, Massimiliano; Kong, Deling; Zhang, Lunan; Murduck, Jared; Yet, Shaw-Fang; Perrella, Mark A; Pratt, Richard E; Dzau, Victor J; Melo, Luis G

    2006-02-01

    We reported previously that predelivery of the anti-oxidant gene heme oxygenase-1 (HO-1) to the heart by adeno associated virus (AAV) markedly reduces injury after acute myocardial infarction (MI). However, the effect of HO-1 gene delivery on postinfarction recovery has not been investigated. In the current study, we assessed the effect of HO-1 gene delivery on post-MI left ventricle (LV) remodeling and function using echocardiographic imaging and histomorphometric approaches. Two groups of Sprague-Dawley rats were injected with 4 x 10(11) particles of AAV-LacZ (control) or AAV-hHO-1 in the LV wall. Eight wk after gene transfer, the animals were subjected to 30 min of ischemia by ligation of left anterior descending artery (LAD) followed by reperfusion. Echocardiographic measurements were obtained in a blinded fashion prior and at 1.5 and 3 months after I/R. Ejection fraction (EF) was reduced by 13% and 40% in the HO-1 and LacZ groups, respectively at 1.5 months after MI. Three months after MI, EF recovered fully in the HO-1, but only partially in the LacZ-treated animals. Post-MI LV dimensions were markedly increased and the anterior wall was markedly thinned in the LacZ-treated animals compared with the HO-1-treated animals. Significant myocardial scarring and fibrosis were observed in the LacZ-group in association with elevated levels of interstitial collagen I and III and MMP-2 activity. Post-MI myofibroblast accumulation was reduced in the HO-1-treated animals, and retroviral overexpression of HO-1 reduced proliferation of isolated cardiac fibroblasts. Our data indicate that rAAV-HO-1 gene transfer markedly reduces fibrosis and ventricular remodeling and restores LV function and chamber dimensions after myocardial infarction.

  5. Prolonged triglyceride storage in macrophages: pHo trumps pO2 and TLR4.

    Science.gov (United States)

    Lu, Mingfang; Kho, Terry; Munford, Robert S

    2014-08-01

    Lipid-laden macrophages contribute to pathologies as diverse as atherosclerosis and tuberculosis. Three common stimuli are known to promote macrophage lipid storage: low tissue oxygen tension (pO2), low extracellular pH (pHo), and exposure to agonists such as bacterial LPS. Noting that cells responding to low pO2 or agonistic bacterial molecules often decrease pHo by secreting lactic and other carboxylic acids, we studied how pHo influences the stimulation of triacylglycerol (TAG) storage by low pO2 and LPS. We found that TAG retention after incubation for 48-72 h was inversely related to pHo when primary macrophages were cultured in 21% oxygen, 4% oxygen, or with LPS at either oxygen concentration. Maintaining pHo at ~7.4 was sufficient to prevent the increase in prolonged TAG storage induced by either low pO2 or LPS. The strong influence of pHo on TAG retention may explain why lipid-laden macrophages are found in some tissue environments and not in others. It is also possible that other long-term cellular changes currently attributed to low pO2 or bacterial agonists may be promoted, at least in part, by the decrease in pHo that these stimuli induce.

  6. HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets

    Directory of Open Access Journals (Sweden)

    Zeid Khitan

    2014-01-01

    Full Text Available Background. Fructose metabolism is an unregulated metabolic pathway and excessive fructose consumption is known to activate ROS. HO-1 is a potent antioxidant gene that plays a key role in decreasing ROS and isoprostanes. We examined whether the fructose-mediated increase in adipocyte dysfunction involves an increase in isoprostanes and that pharmacological induction of HO-1 would decrease both isoprostane levels and adipogenesis. Methods and Results. We examined the effect of fructose, on adipogenesis in human MSCs in the presence and absence of CoPP, an inducer of HO-1. Fructose increased adipogenesis and the number of large lipid droplets while decreasing the number of small lipid droplets (P<0.05. Levels of heme and isoprostane in fructose treated MSC-derived adipocytes were increased. CoPP reversed these effects and markedly increased HO-1 and the Wnt signaling pathway. The high fructose diet increased heme levels in adipose tissue and increased circulating isoprostane levels (P<0.05 versus control. Fructose diets decreased HO-1 and adiponectin levels in adipose tissue. Induction of HO-1 by CoPP decreased isoprostane synthesis (P<0.05 versus fructose. Conclusion. Fructose treatment resulted in increased isoprostane production and adipocyte dysfunction, which was reversed by the increased expression of HO-1.

  7. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted 163Ho ions

    Science.gov (United States)

    Gastaldo, L.; Ranitzsch, P. C.-O.; von Seggern, F.; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-05-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of 163Ho using MMCs having the radioactive 163Ho ions implanted in the absorber. The isotope 163Ho decays through electron capture to 163Dy and features the smallest known QEC value. This peculiarity makes 163Ho a very interesting candidate to investigate the value of the electron neutrino mass by the analysis of the energy spectrum. The implantation of 163Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. Moreover the performance of the detector prototype having the 163Ho ions implanted in the absorber is already close to the requirements needed for an experiment with sub-eV sensitivity to the electron neutrino mass. Based on these results, an optimized detector design for future 163Ho experiments is presented.

  8. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted 163Ho ions

    International Nuclear Information System (INIS)

    Gastaldo, L.; Ranitzsch, P.C.-O.; Seggern, F. von; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-01-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of 163 Ho using MMCs having the radioactive 163 Ho ions implanted in the absorber. The isotope 163 Ho decays through electron capture to 163 Dy and features the smallest known Q EC value. This peculiarity makes 163 Ho a very interesting candidate to investigate the value of the electron neutrino mass by the analysis of the energy spectrum. The implantation of 163 Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. Moreover the performance of the detector prototype having the 163 Ho ions implanted in the absorber is already close to the requirements needed for an experiment with sub-eV sensitivity to the electron neutrino mass. Based on these results, an optimized detector design for future 163 Ho experiments is presented

  9. Návrh změny metody konsolidace u vybraného konsolidovaného celku

    OpenAIRE

    Čadová, Michaela

    2017-01-01

    Téma diplomové práce je konsolidace účetní závěrky. Práce obsahuje teoretická východiska, která se týkají problematiky konsolidace účetní závěrky, a tyto poznatky jsou potom zúročeny v části praktické. Analytická část se zaobírá zhodnocením současného stavu, obsahuje tedy původní konsolidaci účetní závěrky zvolené společnosti. V návrhové části je aplikována nová metoda konsolidace účetní závěrky. Následně je zhodnocen dopad změny konsolidační metody na ekonomickou situaci konsolidačního celku...

  10. Animal experiments and clinical trials of {sup 166}Ho-chitosan for various cancers

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Choi, C W; Kim, E H; Woo, K S; Chung, W S; Lee, J I; Park, S Y; Son, Y S; Lee, S H; Kim, S J; Kim, B G; Kim, J H; Lee, C H [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    1997-07-01

    {sup 166}Ho is a good therapeutic radionuclide because of its suitable half-life (26.8 hours), high beta energy and 6% gamma ray for imaging. Chitosan is a kind of N-glucosamine with 400 to 500 kD MW, which chelates metal ions and degrades slowly in vivo. As a preclinical studies, we performed cytotoxic effect of {sup 166}Ho-chitosan in a variety of cancer cell lines derived from stomach or ovarian cancer based on MTT assay and HTCA method. To evaluated the absorbed dose to the cavitary wall from {sup 166}Ho-chitosan, intraperitoneal administration of {sup 166}Ho-chitosan in the rat and simulation of energy transfer from the beta particles to the cavity wall using the Monte Carlo code EGS4 was done, and used as a standard for the planning therapy. Intracavitary {sup 166}Ho-chitosan therapy were tried in peritoneal metastatic ovarian and stomach cancers and cystic brain tumors. Intraarterial injection in inoperable primary liver cancer was also tried. As a radiation synovectomy agent, biocompatibility study in the knee joints of rabbits were performed. {sup 166}Ho-chitosan showed synergistic effects with 5-FU or cisplatin in vitro. 97-99% of {sup 166}Ho-chitosan was localized within the peritoneal cavity, and more than 90% of {sup 166}Ho-chitosan was attached to the peritoneal wall. Partial response were observed in 4 among 5 patients with ovarian cancer without severe toxicity. In the cystic brain tumor, 5 of 8 cysts were shrunken in size with thinning of the wall, 2 out of 8 showed growth retardation. In the primary liver cancer, radioactivity was distributed in the teritory of selected hepatic arterial branch, and partial responses were observed in 2 cases. In the knee joints of the rabbits, more than 98% of {sup 166}Ho-chitosan remained in the joint cavity and was stable upto 1 week. 49 refs., 22 tabs. (author)

  11. Magnetic and crystallographic properties of HoCo3B2

    International Nuclear Information System (INIS)

    Caspi, E.N.; Dubman, M.; Ettedgui, H.; Shaked, H.; Short, S.; Jorgensen, J.D.

    2005-01-01

    AC-susceptibility measurements for HoCo 3 B 2 show paramagnetism below room temperature and a small, and large anomalies at 150 and 10K, respectively. Neutron powder diffraction measurements show a ferromagnetic order below 10K, where the ferromagnetic Ho and Co sublattices are ferromagnetically coupled. The magnetic axis direction is perpendicular to the c axis. The observed magnitudes of the magnetic moments at 4.5K are 5.08(4) and 0.11(2) μ B for Ho and Co, respectively. No long range magnetic order was detected above 10K

  12. Development of Therapeutic Modality of Esophageal Cancer Using Ho-166 Stent

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Doo; Park, Kwang Kyun; Lee, Min Geol [Yonsei University Medical College, Seoul (Korea, Republic of); Park, Kyung Bae [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-09-01

    The prognosis of esophageal cancer is poor due absence of serosa which prevent local invasion to the surrounding organs such as aorta, mediastinum, trachea, and bronchi. We developed a Ho-166 Coated Radioactive Self-Expandable Metallic Stent which is a new herapeutic device in the treatment of esophageal cancer and underwent an animal experiment in mongrel dogs. We observed mucosal destruction by 4-6 mCi of Ho-166 without serious complications such as perforation of esophageal wall. Therefore, Ho-166 coated self-expandable stent appears to be an effective therapeutic device in the palliative treatment of esophageal cancer. 17 refs., 4 figs. (author)

  13. Sticking of HO2 on fatty acids aggregates

    Science.gov (United States)

    Vardanega, Delphine; Briquez, Stéphane; Duflot, Denis; Monnerville, Maurice; Toubin, Céline

    2015-04-01

    Models of atmospheric chemistry are widely used to perform projections of future changes in the chemical composition of the global troposphere, including changes in climate related greenhouse gases and aerosol particles. However, large uncertainties are still associated with the chemistry implemented in these models, which in turn can lead to inaccurate long-term predictions. The proposed work seeks to improve our understanding of the oxidative capacity of the atmosphere, which drives the lifetime of trace gases, and therefore atmospheric composition. Recent measurements [1] of free radicals made in forested environments characterized by low levels of nitrogen oxides (NOx = NO and NO2) indicate that current models of atmospheric chemistry tend to overestimate the concentration of peroxy radicals (HO2 and RO2). An overestimation of peroxy radicals is an important issue since these radicals are the main precursors of the hydroxyl radical (OH), the most important atmospheric oxidant during daytime. This issue could lead to a significant overestimation of the oxidative capacity of the global atmosphere since more than 86% of the Earth surface is covered by forests, oceans, and polar regions. An analysis of this dataset indicates that the missing sink could be due to an underestimation of the rates of RO2+HO2 reactions, and/or the uptake of peroxy radicals onto aerosol particles. A thorough evaluation of scientific studies published in the literature shows that there is a lack of kinetic and mechanistic data to correctly assess the contribution of these two loss pathways of peroxy radicals in low NOx environments. Classical molecular dynamics simulations, using the Gromacs package [2], are performed to study the interaction of HO2 with organic (carboxylic acid) aerosols. The effect of the presence of water molecules on the surface are also be investigated. These calculations provide theoretical values for observable quantities such as uptake and mass accommodation

  14. Řízení procesu reaktivního magnetronového naprašování

    OpenAIRE

    Dušek, Jan

    2014-01-01

    Bakalářská práce stručně popisuje technologii reaktivního magnetronového naprašování a zabývá se návrhem a realizací programu k jeho ovládání. K tomuto účelu byl vytvořen ovládací program pro řízení jednotlivých komponent aparatury PLS160 v programovacím prostředí LabView. Na základě znalostí technologického procesu a postupu reaktivního magnetronového naprašování byl vytvořen automatický program. Tento automatický program je možné modifikovat pomocí receptů. Vedle programové skladby byly pro...

  15. Efficient High Power Ho,Tm:GdVO4 Laser

    International Nuclear Information System (INIS)

    Wang Yue-Zhu; Zhu Guo-Li; Ju You-Lun; Yao Bao-Quan

    2011-01-01

    We report a 22.3 W cw diode-pumped cryogenic Ho(0.5at.%),Tm(at.5%):GdVO 4 laser at a wavelength of 2.05 μm. It is pumped by two fiber-coupled laser diodes with a fiber core diameter of 0.4 mm, both of which provide 42 W pump power near 802 nm. A cw output power of 22.3 W was obtained at the pump power of 51.0 W, corresponding to an optical-to-optical conversion efficiency of 43.7% when the ratio of the pump beam to oscillating laser beam in the crystal was ∼1.33:1. The M 2 factor was found to be 2.0 under an output power of 16.5 W. (fundamental areas of phenomenology(including applications))

  16. High-pressure phase transition in Ho2O3

    International Nuclear Information System (INIS)

    Lonappan, Dayana; Shekar, N.V. Chandra; Ravindran, T.R.; Sahu, P. Ch.

    2010-01-01

    High-pressure X-ray diffraction and Raman studies on holmium sesquioxide (Ho 2 O 3 ) have been carried out up to a pressure of ∼17 GPa in a diamond-anvil cell at room temperature. Holmium oxide, which has a cubic or bixbyite structure under ambient conditions, undergoes an irreversible structural phase transition at around 9.5 GPa. The high-pressure phase has been identified to be low symmetry monoclinic type. The two phases coexist to up to about 16 GPa, above which the parent phase disappears. The high-pressure laser-Raman studies have revealed that the prominent Raman band ∼370 cm -1 disappears around the similar transition pressure. The bulk modulus of the parent phase is reported.

  17. Distribuce digitálního obsahu

    OpenAIRE

    Voborník, Vojtěch

    2016-01-01

    Bakalářská práce reaguje na současné způsoby distribuce digitálního obsahu na internetu (například audia, videa, softwaru, videoher, e-knih, fotografií apod.) mezi autorem a spotřebitelem, jejich výhody a nevýhody a nabízí alternativní způsob distribuce dosud nezveřejněných digitálních děl, prostřednictvím vytvořené webové stránky, která je výstupem této práce. Bachelor thesis responds to the current distribution methods of digital content on the internet (for example, audio, video, softwa...

  18. Positive parity states in 153Ho and the question of shape coexistence

    International Nuclear Information System (INIS)

    Chakraborty, A.; Ray, Sudatta; Ray, I.; Pradhan, M.K.; Raut, R.; Goswami, A.; Banerjee, P.; Mukherjee, A.; Bhattacharya, S.; Saha Sarkar, M.; Dey, Gautam; Krishichayan; Kshetri, Ritesh; Ganguly, S.; Ray Basu, M.; Ganguly, G.; Ghugre, S.S.; Sinha, A.K.; Basu, S.K.; Sarkar, S.

    2008-01-01

    In the present work the existing level scheme have been extended from the experimental data and studied specifically the positive parity states in 153 Ho theoretically to understand the issue of shape coexistence in this nucleus

  19. Magnetocaloric properties of the hexagonal HoMnO{sub 3} single crystal revisited

    Energy Technology Data Exchange (ETDEWEB)

    Balli, M., E-mail: Mohamed.balli@Usherbrooke.ca [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Roberge, B.; Vermette, J.; Jandl, S. [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Fournier, P. [Regroupement québécois sur les matériaux de pointe, Département de physique, Université de Sherbrooke, QC, Canada J1K 2R1 (Canada); Canadian Institute for Advanced Research, Toronto, Ontario, Canada M5G 1Z8 (Canada); Gospodinov, M.M. [Institute of Solid State Physics, Bulgarian Academy of Science, Sofia 1184 (Bulgaria)

    2015-12-01

    Magnetic and magnetocaloric properties of the hexagonal HoMnO{sub 3} single crystal have been revisited. It was found that the magnetocaloric effect shown by HoMnO{sub 3} strongly depends on the crystal orientation in respect to the applied magnetic field. Consequently, a large thermal effect can be induced by spinning the single crystal HoMnO{sub 3} around the a (or b) axis in a constant magnetic field instead of the conventional magnetization–demagnetization process. Under 7 T, the maximum rotating entropy change was evaluated to be about 8 J/kg K. The associated adiabatic temperature change reaches a value of about 5 K. These values are comparable to those of the other oxides exhibiting a large rotating magnetocaloric effect. The presence of both conventional and rotating thermal effects makes the hexagonal HoMnO{sub 3} more interesting from a practical point of view.

  20. High Power Narrow Linewidth 1.26 Micron Ho-Doped Fiber Amplifier, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for the development of an innovative, high power, and extremely reliable 1.26-micron Ho-doped fluoride fiber amplifier. The proposed fiber amplifier...

  1. High Power Narrow Linewidth 1.26 Micron Ho-Doped Fiber Amplifier, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for the development of an innovative, high power, and extremely reliable 1.26-micron Ho-doped fluoride fiber amplifier. The proposed fiber amplifier...

  2. In situ measurements of HO{sub x} in super- and subsonic aircraft exhaust plumes

    Energy Technology Data Exchange (ETDEWEB)

    Hanisco, T F; Wennberg, P O; Cohen, R C; Anderson, J G [Harvard Univ., Cambridge, MA (United States). Dept. of Chemistry; Fahey, D W; Keim, E R; Gao, R S; Wamsley, R C; Donnelly, S G; Del Negro, L A [National Oceanic and Atmospheric Administration, Boulder, CO (United States). Aeronomy Lab.; others, and

    1998-12-31

    Concentrations of HO{sub x} (OH and HO{sub 2}) have been obtained in the exhaust plumes of an Air France Concorde and a NASA ER-2 in the lower stratosphere and the NASA DC-8 in the upper troposphere using instruments aboard the NASA ER-2. These fast-time response in situ measurements are used in conjunction with simultaneous in situ measurements of other key exhaust species (NO, NO{sub 2}, NO{sub y}, H{sub 2}O, and CO) to analyze the emissions of HO{sub x} from each aircraft under a variety of conditions. The data are used to establish a general description of gas phase plume chemistry that is easily implemented in a photochemical model. This model is used to determine the amount of HO{sub x} emitted from the engines and the gas phase oxidation rates of nitrogen and sulfur species in the exhaust plumes. (author) 10 refs.

  3. Technical cooperation for the wider uses of Ho-166 therapeutic agents in European countries

    CERN Document Server

    Park, K B; Choi, S M; Han, K H; Hong, Y D; Park, W W; Shin, B C

    2002-01-01

    Czech has put their priority in developing the radiopharmaceuticals based on reactor produced Ho-166 and a related fabrication will be extended to other EU conturies including Germany, France, etc after a development of project. The collaboration will be based on the mutual agreement for developing the between research institutes, industries and academic institutes and further researches should be followed by the issue of developing radiopharmaceuticals using Ho-166. To strengthen the collaboration, detailed discussions for the practical collaboration have been made through the visitation to the research institution of each counter part. For implementing the collaboration between NPI and KAERI, an institutional basis technical cooperation agreement(TCA) will be concluded. Furthermore, agreement for the substantial collaboration on Ho-166 related researches will be made after the conclusion of the TCA. It will accelerate the commercialization of KAERI developed Ho-166 therapeutic agents into other European cou...

  4. In situ measurements of HO{sub x} in super- and subsonic aircraft exhaust plumes

    Energy Technology Data Exchange (ETDEWEB)

    Hanisco, T.F.; Wennberg, P.O.; Cohen, R.C.; Anderson, J.G. [Harvard Univ., Cambridge, MA (United States). Dept. of Chemistry; Fahey, D.W.; Keim, E.R.; Gao, R.S.; Wamsley, R.C.; Donnelly, S.G.; Del Negro, L.A. [National Oceanic and Atmospheric Administration, Boulder, CO (United States). Aeronomy Lab.; and others

    1997-12-31

    Concentrations of HO{sub x} (OH and HO{sub 2}) have been obtained in the exhaust plumes of an Air France Concorde and a NASA ER-2 in the lower stratosphere and the NASA DC-8 in the upper troposphere using instruments aboard the NASA ER-2. These fast-time response in situ measurements are used in conjunction with simultaneous in situ measurements of other key exhaust species (NO, NO{sub 2}, NO{sub y}, H{sub 2}O, and CO) to analyze the emissions of HO{sub x} from each aircraft under a variety of conditions. The data are used to establish a general description of gas phase plume chemistry that is easily implemented in a photochemical model. This model is used to determine the amount of HO{sub x} emitted from the engines and the gas phase oxidation rates of nitrogen and sulfur species in the exhaust plumes. (author) 10 refs.

  5. Characterization of low temperature metallic magnetic calorimeters having gold absorbers with implanted $^{163}$Ho ions

    CERN Document Server

    Gastaldo, L.; von Seggern, F.; Porst, J.-P.; Schäfer, S.; Pies, C.; Kempf, S.; Wolf, T.; Fleischmann, A.; Enss, C.; Herlert, A.; Johnston, K.

    2013-01-01

    For the first time we have investigated the behavior of fully micro-fabricated low temperature metallic magnetic calorimeters (MMCs) after undergoing an ion-implantation process. This experiment had the aim to show the possibility to perform a high precision calorimetric measurement of the energy spectrum following the electron capture of $^{163}$Ho using MMCs having the radioactive $^{163}$Ho ions implanted in the absorber. The implantation of $^{163}$Ho ions was performed at ISOLDE-CERN. The performance of a detector that underwent an ion-implantation process is compared to the one of a detector without implanted ions. The results show that the implantation dose of ions used in this experiment does not compromise the properties of the detector. In addition an optimized detector design for future $^{163}$Ho experiments is presented.

  6. Podnikatelský plán pro transformaci rodinného podniku

    OpenAIRE

    Paníček, Roman

    2011-01-01

    Diplomová práce se zabývá transformací rodinného podniku z obchodního centra na taneční klub. Jedná se zde o kompletní analýzu vnitřního i vnějšího prostředí a z ní vyvozené závěry. Práce obsahuje zdroje financování, celkové náklady a odhadovaný vývoj do budoucna. Dále zde nalezneme marketingový mix a harmonogram implementace. This diploma thesis deals with the transformation of the family business from the commercial center to the dance club. Its mean that it contains complete analysis of...

  7. Prompt HO2 formation following the reaction of OH with aromatic compounds under atmospheric conditions.

    Science.gov (United States)

    Nehr, Sascha; Bohn, Birger; Wahner, Andreas

    2012-06-21

    The secondary formation of HO(2) radicals following OH + aromatic hydrocarbon reactions in synthetic air under normal pressure and temperature was investigated in the absence of NO after pulsed production of OH radicals. OH and HO(x) (=OH + HO(2)) decay curves were recorded using laser-induced fluorescence after gas-expansion. The prompt HO(2) yields (HO(2) formed without preceding NO reactions) were determined by comparison to results obtained with CO as a reference compound. This approach was recently introduced and applied to the OH + benzene reaction and was extended here for a number of monocyclic aromatic hydrocarbons. The measured HO(2) formation yields are as follows: toluene, 0.42 ± 0.11; ethylbenzene, 0.53 ± 0.10; o-xylene, 0.41 ± 0.08; m-xylene, 0.27 ± 0.06; p-xylene, 0.40 ± 0.09; 1,2,3-trimethylbenzene, 0.31 ± 0.06; 1,2,4-trimethylbenzene, 0.37 ± 0.09; 1,3,5-trimethylbenzene, 0.29 ± 0.08; hexamethylbenzene, 0.32 ± 0.08; phenol, 0.89 ± 0.29; o-cresol, 0.87 ± 0.29; 2,5-dimethylphenol, 0.72 ± 0.12; 2,4,6-trimethylphenol, 0.45 ± 0.13. For the alkylbenzenes HO(2) is the proposed coproduct of phenols, epoxides, and possibly oxepins formed in secondary reactions with O(2). In most product studies the only quantified coproducts were phenols whereas only a few studies reported yields of epoxides. Oxepins have not been observed so far. Together with the yields of phenols from other studies, the HO(2) yields determined in this work set an upper limit to the combined yields of epoxides and oxepins that was found to be significant (≤0.3) for all investigated alkylbenzenes except m-xylene. For the hydroxybenzenes the currently proposed HO(2) coproducts are dihydroxybenzenes. For phenol and o-cresol the determined HO(2) yields are matching the previously reported dihydroxybenzene yields, indicating that these are the only HO(2) forming reaction channels. For 2,5-dimethylphenol and 2,4,6-trimethylphenol no complementary product studies are available.

  8. 166 Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment

    International Nuclear Information System (INIS)

    Chandia, M; Errazu, X; Mendoza, P; Troncoso, F; Jofre, J; Sierralta, P

    2003-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate 166 Ho-Hydroxyapatite ( 166 Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: 166 Holmiun was produced by irradiation of Ho 2 O 3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the 166 Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using 67 Ga citrate before and after 166 Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The 166 Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extraarticular leakage. From the 67 Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The 166 Ho-HA double dosis, compared to the single dosis, suggest a reduced uptake of 67 Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: 166 Ho-HA is usefull as therapeutic agent for the syntomatic treatment of rheumatoideal arthritis as shown by imaging and clinical examination (author)

  9. 166Ho-HA evaluation as therapeutic agent for rheumatoid arthritis treatment

    International Nuclear Information System (INIS)

    Chandia, M.C.; Errazu, X.C.; Pinto, L.N.; Godoy, N.O.; Avila, M.J.; Mendoza, P.; Mendoza, J.; Jofre, J.; Sirraalta, P.

    2002-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate 166 Ho-Hydroxyapatite ( 166 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho 2 O 3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the 166 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using 67 Ga citrate before and after 166 Ho-HA injection. Results: The radiochemical purity of the inoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflammation reduction (2 cm), appetite improvement and general well being was observed. The 166 Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extra articular leakage. From the 67 Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The 166 Ho-HA double doses, compared to the single doses, suggest a reduced uptake of 67 Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: 166 Ho-HA is useful as therapeutic agent for the symptomatic treatment of rheumatoid arthritis as shown by imaging and clinical examination

  10. OH and HO2 chemistry in clean marine air during SOAPEX-2

    Directory of Open Access Journals (Sweden)

    R. Sommariva

    2004-01-01

    Full Text Available Model-measurement comparisons of HOx in extremely clean air ([NO] The free-radical chemistry was studied using a zero-dimensional box-model based upon the Master Chemical Mechanism (MCM. Two versions of the model were used, with different levels of chemical complexity, to explore the role of hydrocarbons upon free-radical budgets under very clean conditions. The "detailed" model was constrained to measurements of CO, CH4 and 17 NMHCs, while the "simple" model contained only the CO and CH4 oxidation mechanisms, together with inorganic chemistry. The OH and HO2 (HOx concentrations predicted by the two models agreed to within 5–10%. The model results were compared with the HOx concentrations measured by the FAGE (Fluorescence Assay by Gas Expansion technique during four days of clean Southern Ocean marine boundary layer (MBL air. The models overestimated OH concentrations by about 10% on two days and about 20% on the other two days. HO2 concentrations were measured during two of these days and the models overestimated the measured concentrations by about 40%. Better agreement with measured HO2 was observed by using data from several MBL aerosol measurements to estimate the aerosol surface area and by increasing the HO2 uptake coefficient to unity. This reduced the modelled HO2 overestimate by ~40%, with little effect on OH, because of the poor HO2 to OH conversion at the low ambient NOx concentrations. Local sensitivity analysis and Morris One-At-A-Time analysis were performed on the "simple" model, and showed the importance of reliable measurements of j(O1D and [HCHO] and of the kinetic parameters that determine the efficiency of O(1D to OH and HCHO to HO2 conversion. A 2σ standard deviation of 30–40% for OH and 25–30% for HO2 was estimated for the model calculations using a Monte Carlo technique coupled with Latin Hypercube Sampling (LHS.

  11. A critical scattering study of the helical antiferromagnets Ho and Dy

    International Nuclear Information System (INIS)

    Gaulin, B.D.; Hagen, M.; Child, H.R.

    1988-01-01

    We have measured the frequency integrated magnetic critical scattering of neutrons from paramagnetic Dy and Ho. Analysis of these data show the paramagnetic to helical antiferromagnetic phase transitions are characterized by the critical exponents ν = 0.57 +- 0.05 and γ = 1.05 = +- .07 for Dy and ν = 0.57 +- .04 and γ = 1.14 = +- .10 for Ho. 3 refs., 2 figs., 1 tab

  12. FAGE measurements of tropospheric HO with measurements and model of interferences

    Science.gov (United States)

    Hard, T. M.; Mehrabzadeh, A. A.; Chan, C. Y.; O'Brien, R. J.

    1992-01-01

    Ambient HO measurements by low-pressure laser-excited fluorescence with chemical modulation, and supporting ozone and water-vapor data, are presented for periods in May and August 1987. The observed peak daytime ambient HO concentrations are in the range (2.5 to 8) x 10 exp 6 molecules/cu cm and show small negative offsets due to photochemical interference. Direct measurements of the interference at fixed (O3) give the dependence on ambient (H2O) and on the modulating reagent (isobutane). At ambient (O3) = 30 ppb and 10 torr H2O, with excitation and detection at a total pressure of 4 torr, the net interference is equal to (HO) = -1.3 x 10 exp 6 molecules/cu cm. Production of HO by the reaction of isobutane with O(1D) accounts for the negative interference. Quenching of HO fluorescence by the modulating reagent contributes a smaller positive term to the interference; kinetic measurements of the quenching rate coefficient are reported. The experimental interference results are compared with a detailed kinetic model of HO production, excitation, relaxation, and detection; reasonable agreement is found.

  13. Study on preparation of 166Ho-Chitosan oriented in the treatment of liver cancer

    International Nuclear Information System (INIS)

    Dang Ho Hong Quang; Duong Van Dong; Bui Van Cuong; Nguyen Thanh Binh; Nguyen Thanh Nhan; Nguyen Dinh Lam; Nguyen Thi Thu

    2017-01-01

    This study describes the process for the preparation and quality control of 166 Ho-Chitosan product. The labeling conditions of chitosan with 166 Ho radioisotope were carried out such as the concentration of chitosan, pH, temperature and reaction time to create 166 Ho-Chitosan compositions. Product quality inspection 166 Ho-Chitosan on the criteria as nuclide purity, radiochemical purity, tested for sterility and bacterial endotoxin. The results of survey showed that 166 Ho labeled with chitosan were completed in 1% acetic acid, 3 mCi: 30 mg ratio at pH = 3, marking time at room temperature for 30 minutes. The results of quality test have shown radionuclide purity ≥ 99%, radiochemical purity ≥ 98%, meeting the criteria for the aseptic and bacterial endotoxin according to IV Vietnam pharmacopoeia. From the above mentioned, 166 Ho-Chitosan compositions meet the quality criteria of the radiopharmaceuticals, therefore, it can be used in pre-clinical research and its application in clinical treatment. (author)

  14. Návrh Rail-to-Rail proudového konvejoru v technologii CMOS

    OpenAIRE

    Hudzik, Martin

    2016-01-01

    Diplomová práca sa zaoberá návrhom rail-to-rail prúdového konvejora druhej generácie v technológii CMOS. Opisuje princípy funkcie jednotlivých generácii prúdových konvejorov a taktiež základný princíp návrhu prúdového konvejora druhej generácie založeného na operačnom zosilňovači. Venuje sa obvodovému riešeniu vstupného rail-to-rail stupňa a koncového stupňa v triede AB. Cieľom tejto práce je navrhnúť, charakterizovať vlastnosti a vytvoriť topológiu prúdového konvejora druhej generácie s rail...

  15. Theoretical investigation of electronic and magnetic properties of HoRh layers

    International Nuclear Information System (INIS)

    Masrour, R.; Hlil, E.K.; Hamedoun, M.; Benyoussef, A.; Mounkachi, O.; Bahmad, L.; El Moussaoui, H.

    2013-01-01

    Self-consistent ab initio calculations, based on Density Functional Theory (DFT) approach and using Full potential Linear Augmented Plane Wave (FLAPW) method, are performed to investigate both electronic and magnetic properties of the HoRh layers. Polarized spin and spin–orbit coupling are included in calculations within the framework of the antiferromagnetic state between two sites of Ho. Magnetic moment considered to lie along (001) axes are computed. The data obtained from the ab initio calculations are then used as input for the high temperature series expansions (HTSEs) calculations to compute other magnetic parameters. The exchange integrals between the magnetic atoms in the same sites are given by using mean field theory. The HTSEs of the magnetic susceptibility of HoRh layers spin-S through the Ising model for HoRh layers, are studied to tenth order series in β=1/k B T. The critical exponent γ associated with the magnetic susceptibility is deduced for two models. - Highlights: • Ab initio calculations is using to investigate both electronic and magnetic properties of the HoRh layers. • Obtained data from ab initio calculations are used as input for the HTSEs. • The Néel temperature is obtained for HoRh layers

  16. Study on the preparation of 166Ho-patch for a skin cancer treatment

    International Nuclear Information System (INIS)

    Kim, Y. M.; Kim, K. H.; Han, K. H.; Park, E. W.; Shin, B. C.; Park, K. B.; Lee, J. D.

    1998-01-01

    Radioactive patch containing holmium-166 has been developed for skin cancer treatment, and then applied to animal model and patients with malignant skin cancer. 165Ho-Patch prepared by dissolving polyurethane and 165 Ho(NO 3 ) 3 ·5H 2 O in mixing solvent of DMF and THF and casting on aluminium dish was irradiated in ''HANARO'' reactor ( Φth = 1.25 X 1013 n/cm 2 '·sec, power = 15 MW), which results in preparing 166 Ho-Patch emitting β energy of Max. 1.86 MeV (51 %), 1.78 MeV (48 %), mean 0.67 MeV and low γ energy. The 166 Ho-Patch specially designed was applied to the superficial skin cancers. Their efficacy and safety have been investigated for several months. Radioactive patch was ready to prepare by post-irradiation without special danger by radioactive material. Skin tumor could be successfully treated with 166 Ho-Patch in animal model and patients. In animal model and patients, the world's first noninvasive 166Ho-Patch readily prepared by post-irradiation proved to be safe and effective in treatment for skin cancer

  17. Theoretical investigation of electronic and magnetic properties of HoRh layers

    Energy Technology Data Exchange (ETDEWEB)

    Masrour, R., E-mail: rachidmasrour@hotmail.com [Laboratory of Materials, Processes, Environment and Quality, Cady Ayyed University, National School of Applied Sciences, Sidi Bouzid, Safi (Morocco); LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); Hlil, E.K. [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble cedex 9 (France); Hamedoun, M. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Benyoussef, A. [LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Hassan II Academy of Science and Technology, Rabat (Morocco); Mounkachi, O. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco); Bahmad, L. [LMPHE (URAC 12), Faculty of Science, Mohammed V-Agdal University, Rabat (Morocco); El Moussaoui, H. [Institute of Nanomaterials and Nanotechnologies, MAScIR, Rabat (Morocco)

    2013-10-15

    Self-consistent ab initio calculations, based on Density Functional Theory (DFT) approach and using Full potential Linear Augmented Plane Wave (FLAPW) method, are performed to investigate both electronic and magnetic properties of the HoRh layers. Polarized spin and spin–orbit coupling are included in calculations within the framework of the antiferromagnetic state between two sites of Ho. Magnetic moment considered to lie along (001) axes are computed. The data obtained from the ab initio calculations are then used as input for the high temperature series expansions (HTSEs) calculations to compute other magnetic parameters. The exchange integrals between the magnetic atoms in the same sites are given by using mean field theory. The HTSEs of the magnetic susceptibility of HoRh layers spin-S through the Ising model for HoRh layers, are studied to tenth order series in β=1/k{sub B}T. The critical exponent γ associated with the magnetic susceptibility is deduced for two models. - Highlights: • Ab initio calculations is using to investigate both electronic and magnetic properties of the HoRh layers. • Obtained data from ab initio calculations are used as input for the HTSEs. • The Néel temperature is obtained for HoRh layers.

  18. Characteristics of gait ataxia in δ2 glutamate receptor mutant mice, ho15J.

    Directory of Open Access Journals (Sweden)

    Eri Takeuchi

    Full Text Available The cerebellum plays a fundamental, but as yet poorly understood, role in the control of locomotion. Recently, mice with gene mutations or knockouts have been used to investigate various aspects of cerebellar function with regard to locomotion. Although many of the mutant mice exhibit severe gait ataxia, kinematic analyses of limb movements have been performed in only a few cases. Here, we investigated locomotion in ho15J mice that have a mutation of the δ2 glutamate receptor. The cerebellum of ho15J mice shows a severe reduction in the number of parallel fiber-Purkinje synapses compared with wild-type mice. Analysis of hindlimb kinematics during treadmill locomotion showed abnormal hindlimb movements characterized by excessive toe elevation during the swing phase, and by severe hyperflexion of the ankles in ho15J mice. The great trochanter heights in ho15J mice were lower than in wild-type mice throughout the step cycle. However, there were no significant differences in various temporal parameters between ho15J and wild-type mice. We suggest that dysfunction of the cerebellar neuronal circuits underlies the observed characteristic kinematic abnormality of hindlimb movements during locomotion of ho15J mice.

  19. GEC-targeted HO-1 expression reduces proteinuria in glomerular immune injury.

    Science.gov (United States)

    Duann, Pu; Lianos, Elias A

    2009-09-01

    Induction of heme oxygenase (HO)-1 is a key defense mechanism against oxidative stress. Compared with tubules, glomeruli are refractory to HO-1 upregulation in response to injury. This can be a disadvantage as it may be associated with insufficient production of cytoprotective heme-degradation metabolites. We, therefore, explored whether 1) targeted HO-1 expression can be achieved in glomeruli without altering their physiological integrity and 2) this expression reduces proteinuria in immune injury induced by an anti-glomerular basement membrane (GBM) antibody (Ab). We employed a 4.125-kb fragment of a mouse nephrin promoter downstream to which a FLAG-tagged hHO-1 cDNA sequence was inserted and subsequently generated transgenic mice from the FVB/N parental strain. There was a 16-fold higher transgene expression in the kidney than nonspecific background (liver) while the transprotein immunolocalized in glomerular epithelial cells (GEC). There was no change in urinary protein excretion, indicating that GEC-targeted HO-1 expression had no effect on glomerular protein permeability. Urinary protein excretion in transgenic mice with anti-GBM Ab injury (days 3 and 6) was significantly lower compared with wild-type controls. There was no significant change in renal expression levels of profibrotic (TGF-beta1) or anti-inflammatory (IL-10) cytokines in transgenic mice with anti-GBM Ab injury. These observations indicate that GEC-targeted HO-1 expression does not alter glomerular physiological integrity and reduces proteinuria in glomerular immune injury.

  20. Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway

    Directory of Open Access Journals (Sweden)

    Miao Yu

    2017-06-01

    Full Text Available Deoxynivalenol (DON belongs to the type B group of trichothecenes family, which is composed of sesquiterpenoid metabolites produced by Fusarium and other fungi in grain. DON may cause various toxicities, such as cytotoxicity, immunotoxicity, genotoxicity as well as teratogenicity and carcinogenicity. In the present study, we focus on a hypothesis that DON alters the expressions of Nrf2/HO-1 pathway by inducing embryotoxicity in C57BL/6 mouse (5.0, 2.5, 1.0, and 0 mg/kg/day and BeWo cell lines (0 and 50 nM; 3 h, 12 h and 24 h. Our results indicate that DON treatment in mice during pregnancy leads to ROS accumulation in the placenta, which results in embryotoxicity. At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage. In DON-treated BeWo cells, the level of ROS has time–effect and dose–effect relationships with HO-1 expression. Moderate increase in HO-1 protects the cell from oxidative damage, while excessive increase in HO-1 aggravates the oxidative damage, which is called in some studies the “threshold effect”. Therefore, oxidative stress may be the critical molecular mechanism for DON-induced embryotoxicity. Besides, Nrf2/HO-1 pathway accompanied by the “threshold effect” also plays an important role against DON-induced oxidative damage in this process.

  1. Optical and Physical Investigations of Lanthanum Bismuth Borate glasses doped with Ho2O3

    Science.gov (United States)

    Ramesh, P.; Jagannath, G.; Eraiah, B.; Kokila, M. K.

    2018-02-01

    Holmium doped 10La2O3-15Bi2O3-(75-x) B2O3 (Ho3+: LBB) glasses have been prepared by melt quench technique and the impact of holmium ions concentration on optical and physical properties of present glasses have been examined. Ho3+ dependent density, molar volume, refractive index, rare earth ion concentration, polaron radius, inter ionic distance, field strength and energy band gap are calculated and tabulated. Amorphous nature of the all glasses has been confirmed by XRD patterns. The room temperature (RT) Uv-Vis absorption spectrum doped with 1 mol% of Ho2O3 exhibit eight prominent bands centred at 895, 641, 537, 486, 472, 467, 451 and 416 due to transition between ground state to various excited states. The results show that, the density is increases and molar volume of the glasses is decreases with an increase in Ho2O3 concentration and consequently generate more non-bridging oxygen (NBOs) in the glass matrix. The Urbach energy is increases with holmium concentration which exemplifies the degree of disorder present in the LBB glasses. The considerable increase in field strength observed in present glasses is attributed to occurrence of strong bridge between Ho3+ and B- ions and this strong bridge is possibly due to the displacement between Ho3+ and oxygen atoms which are generated from the conversion BO3-BO4 units.

  2. 36 W Q-switched Ho:YAG laser at 2097 nm pumped by a Tm fiber laser: evaluation of different Ho3+ doping concentrations

    Science.gov (United States)

    Antipov, O. L.; Eranov, I. D.; Kositsyn, R. I.

    2017-01-01

    A laser oscillator based on Ho:YAG crystal pumped by a Tm fiber laser with an acousto-optical Q-switch was optimized for maximum output power and pulse-to-pulse stability. Stable operation at 2097 nm in Q-switched mode is demonstrated, with pulse repetition rates from 10 to 30 kHz, and output power of 36 W (at 55 W of pump power at 1908 nm) in the good quality beam. The influence of Ho ion up-conversion and thermal lensing on the oscillation efficiency is discussed.

  3. High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model.

    Science.gov (United States)

    Ranganathan, Kavitha; Hong, Xiaowei; Cholok, David; Habbouche, Joe; Priest, Caitlin; Breuler, Christopher; Chung, Michael; Li, John; Kaura, Arminder; Hsieh, Hsiao Hsin Sung; Butts, Jonathan; Ucer, Serra; Schwartz, Ean; Buchman, Steven R; Stegemann, Jan P; Deng, Cheri X; Levi, Benjamin

    2018-04-01

    Early treatment of heterotopic ossification (HO) is currently limited by delayed diagnosis due to limited visualization at early time points. In this study, we validate the use of spectral ultrasound imaging (SUSI) in an animal model to detect HO as early as one week after burn tenotomy. Concurrent SUSI, micro CT, and histology at 1, 2, 4, and 9weeks post-injury were used to follow the progression of HO after an Achilles tenotomy and 30% total body surface area burn (n=3-5 limbs per time point). To compare the use of SUSI in different types of injury models, mice (n=5 per group) underwent either burn/tenotomy or skin incision injury and were imaged using a 55MHz probe on VisualSonics VEVO 770 system at one week post injury to evaluate the ability of SUSI to distinguish between edema and HO. Average acoustic concentration (AAC) and average scatterer diameter (ASD) were calculated for each ultrasound image frame. Micro CT was used to calculate the total volume of HO. Histology was used to confirm bone formation. Using SUSI, HO was visualized as early as 1week after injury. HO was visualized earliest by 4weeks after injury by micro CT. The average acoustic concentration of HO was 33% more than that of the control limb (n=5). Spectroscopic foci of HO present at 1week that persisted throughout all time points correlated with the HO present at 9weeks on micro CT imaging. SUSI visualizes HO as early as one week after injury in an animal model. SUSI represents a new imaging modality with promise for early diagnosis of HO. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. HoYbBIG epitaxial thick films used for Faraday rotator in the 1.55μm band

    International Nuclear Information System (INIS)

    Zhong, Z.W.; Xu, X.W.; Chong, T.C.; Yuan, S.N.; Li, M.H.; Zhang, G.Y.; Freeman, B.

    2005-01-01

    Ho 3-x-y Yb y Bi x Fe 5 O 12 (HoYbBIG) garnet thick films with Bi content of x=0.9-1.5 were prepared by the liquid phase epitaxy (LPE) method. Optical properties and magneto-optical properties were characterized. The LPE-grown HoYbBIG thick films exhibited large Faraday rotation coefficients up to 1540 o /cm at 1.55μm, and good wavelength and temperature stability

  5. Animal experiments and clinical trials of 166Ho-Chitosan for various cancers

    International Nuclear Information System (INIS)

    Lim, S.M.; Choi, C.W.; Park, S.Y.; Lee, S.H.; Lee, B.H.; Park, K.B.

    1998-01-01

    166 Ho-Chitosan is a complex of 166 Ho and N-glucosamine with 400 to 500 kD MW, which chelates metal ions and degrades slowly in vivo. In mice, 166 H-Chitosan administered intraperitoneally was uniformly bound to the peritoneal wall (94%), and the surface dose calculated by Monte Carlo simulation (EGS 4 code) was 81 Gy/uCi/cm 2 . 166 Ho-Chitosan was administered intraperitoneally as an adjunct in the treatment of ovarian cancer with diffuse spread of malignant cells in the peritoneal surfaces including the diaphragm. 97-99% of 166 Ho-Chitosan was localized within the peritoneal cavity, and more than 90% of 166 Ho-Chitosan was attached to the peritoneal wall. Partial response were observed in 4 among 5 patients with ovarian cancer without severe toxicity. Intracavitary radiation therapy with 166 Ho-Chitosan in the cystic brain tumor, 5 or 8 cysts were shrunken in size with thinning of the wall, 2 out of 8 showed growth retardation. For large or multiple primary liver cancers, which were inoperable and resistent to chemotherapy. 166 Ho-Chitosan was used for intraarterial injection, because this solution became gel with neutral pH. In the primary liver cancer, radioactivity was distributed in the territory of selected hepatic arterial branch, and partial responses were observed in 2 cases. For the large solitary liver tumor, which was not operable due to its location, direct intratumoral injection of the radioisotope had a limited response. 18 FDG PET was a useful tool to follow up those radionuclide therapy, and guide to plan the next therapy. In one case of the large single metastatic stomach cancer in the liver, 18 FDG PET was done two weeks after intratumoral injection of 166 Ho-Chitosan, which showed cold defects matched with distribution of 166 Ho-Chitosan, and second injection was guided by PET image. Various methods of the administration of 166 Ho-Chitosan could be used for the treatment of the cancers. (author)

  6. Selective degradation of lignin and elimination of HO radicals in pulps by O3 and UV laser flash irradiation

    Institute of Scientific and Technical Information of China (English)

    林鹿; 周贤涛; 邱玉桂

    2002-01-01

    HO radical is an aggressive reagent to abstract hydrogen from diverse substitutes and lead them to degradation, however, in reaction of active oxygen species with lignins, complex phenolic polymers, in dispersed lignocellulose such as pulp for environment-benign delignification, HO radicals should be eliminated as more as possible to prevent cellulose from unfavorably concomitant degradation. A reaction system of O3 is constructed under UV laser flash irradiation, and HO radicals are controlled efficiently by it. A new mechanism is proposed, for the first time, that O radicals generated from reaction of O3 with UV laser flash irradiation might be the contributor to scavenge HO radicals.

  7. Production, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent

    Directory of Open Access Journals (Sweden)

    Samaneh Zolghadri

    2013-05-01

    Full Text Available Objective(s:In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid (166Ho-PDTMP complex  was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1 of natural Ho(NO33 samples  followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed. Results: The complex was prepared with thespecific activity of 278 GBq/mg and high radiochemical purity (>99%, checked by ITLC. 166Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>90% up to 72 hr. The biodistribution of 166Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to 48 hr compared to 166HoCl3. Conclusion: The produced 166Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.  

  8. Optical spectroscopy and luminescence properties of Ho3+ doped zinc fluorophosphate (ZFP) glasses for green luminescent device applications

    Science.gov (United States)

    Reddy Prasad, V.; Damodaraiah, S.; Ratnakaram, Y. C.

    2018-04-01

    Ho3+ doped zinc fluorophosphate (ZFP) glasses with molar chemical compositions, (60-x) NH4H2PO4+20ZnO+10BaF2+10NaF+xHo2O3 (where x = 0.1, 0.3, 0.5, 1.0 and 1.5 mol%) were prepared by melt quenching technique. These glasses were characterized through physical, structural, optical, excitation, luminescence and decay curve analysis. From the absorption spectra, spectral intensities (fexp and fcal), Judd-Ofelt intensity parameters (Ω2, Ω4 and Ω6), radiative transition probabilities (AT), radiative lifetimes (τR) and branching ratios (βR) were evaluated for all Ho3+ doped ZFP glass matrices. From the photoluminescence spectra, peak stimulated emission cross-sections (σP) were calculated for all Ho3+ doped ZFP glasses. The Ho3+ doped ZFP glasses show strong green emission at 545 nm and red emission at 656 nm under excitation, 450 nm. The measured lifetimes (τmeas) of (5S2)5F4 level of Ho3+ doped ZFP glasses were obtained from decay profiles. The CIE color coordinates of Ho3+ doped ZFP glasses were calculated from emission spectra and 1.0 mol% of Ho3+ doped ZFP glass matrix gives green emission. Hence, these results confirm that the Ho3+ doped ZFP glasses could be considered as a promising candidate for visible green laser applications.

  9. Heterogeneous reaction of HO2 with airborne TiO2 particles and its implication for climate change mitigation strategies

    Science.gov (United States)

    Moon, Daniel R.; Taverna, Giorgio S.; Anduix-Canto, Clara; Ingham, Trevor; Chipperfield, Martyn P.; Seakins, Paul W.; Baeza-Romero, Maria-Teresa; Heard, Dwayne E.

    2018-01-01

    One geoengineering mitigation strategy for global temperature rises resulting from the increased concentrations of greenhouse gases is to inject particles into the stratosphere to scatter solar radiation back to space, with TiO2 particles emerging as a possible candidate. Uptake coefficients of HO2, γ(HO2), onto sub-micrometre TiO2 particles were measured at room temperature and different relative humidities (RHs) using an atmospheric pressure aerosol flow tube coupled to a sensitive HO2 detector. Values of γ(HO2) increased from 0.021 ± 0.001 to 0.036 ± 0.007 as the RH was increased from 11 to 66 %, and the increase in γ(HO2) correlated with the number of monolayers of water surrounding the TiO2 particles. The impact of the uptake of HO2 onto TiO2 particles on stratospheric concentrations of HO2 and O3 was simulated using the TOMCAT three-dimensional chemical transport model. The model showed that, when injecting the amount of TiO2 required to achieve the same cooling effect as the Mt Pinatubo eruption, heterogeneous reactions between HO2 and TiO2 would have a negligible effect on stratospheric concentrations of HO2 and O3.

  10. Heterogeneous reaction of HO2 with airborne TiO2 particles and its implication for climate change mitigation strategies

    Directory of Open Access Journals (Sweden)

    D. R. Moon

    2018-01-01

    Full Text Available One geoengineering mitigation strategy for global temperature rises resulting from the increased concentrations of greenhouse gases is to inject particles into the stratosphere to scatter solar radiation back to space, with TiO2 particles emerging as a possible candidate. Uptake coefficients of HO2, γ(HO2, onto sub-micrometre TiO2 particles were measured at room temperature and different relative humidities (RHs using an atmospheric pressure aerosol flow tube coupled to a sensitive HO2 detector. Values of γ(HO2 increased from 0.021 ± 0.001 to 0.036 ± 0.007 as the RH was increased from 11 to 66 %, and the increase in γ(HO2 correlated with the number of monolayers of water surrounding the TiO2 particles. The impact of the uptake of HO2 onto TiO2 particles on stratospheric concentrations of HO2 and O3 was simulated using the TOMCAT three-dimensional chemical transport model. The model showed that, when injecting the amount of TiO2 required to achieve the same cooling effect as the Mt Pinatubo eruption, heterogeneous reactions between HO2 and TiO2 would have a negligible effect on stratospheric concentrations of HO2 and O3.

  11. Density-functional study of the structures and properties of holmium-doped silicon clusters HoSi n (n = 3-9) and their anions.

    Science.gov (United States)

    Hou, Liyuan; Yang, Jucai; Liu, Yuming

    2017-04-01

    The structures and properties of Ho-doped Si clusters, including their adiabatic electron affinities (AEAs), simulated photoelectron spectra (PESs), stabilities, magnetic moments, and charge-transfer characteristics, were systematically investigated using four density-functional methods. The results show that the double-hybrid functional (which includes an MP2 correlation component) can accurately predict the ground-state structure and properties of Ho-doped Si clusters. The ground-state structures of HoSi n (n = 3-9) are sextuplet electronic states. The structures of these Ho-doped Si clusters (aside from HoSi 7 ) are substitutional. The ground-state structures of HoSi n - are quintuplet electronic states. Their predicted AEAs are in excellent agreement with the experimental ones. The mean absolute error in the theoretical AEAs of HoSi n (n = 4-9) is only 0.04 eV. The simulated PESs for HoSi n - (n = 5-9) are in good agreement with the experimental PESs. Based on its simulated PES and theoretical AEA, we reassigned the experimental PES of HoSi 4 - and obtained an experimental AEA of 2.2 ± 0.1 eV. The dissociation energies of Ho from HoSi n and HoSi n - (n = 3-9) were evaluated to test the relative stabilities of the clusters. HOMO-LUMO gap analysis indicated that doping the Si clusters with the rare-earth metal atom significantly increases their photochemical reactivity. Natural population analysis showed that the magnetic moments of HoSi n (n = 3-9) and their anions derive mainly from the Ho atom. It was also found that the magnetic moments of Ho in the HoSi n clusters are larger than the magnetic moment of an isolated Ho atom.

  12. Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway.

    Science.gov (United States)

    Qing, Rui; Huang, Zezhi; Tang, Yufei; Xiang, Qingke; Yang, Fan

    2018-04-24

    The present study is to investigate the protective effect of cordycepin on inflammatory reactions in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS), as well as the underlying mechanism. Wistar rat model of ALI was induced by intravenous injection of LPS (30 mg/kg body weight). One hour later, intravenous injection of cordycepin (1, 10 or 30 mg/kg body weight) was administered. The wet-to-dry weight ratio of lung tissues and myeloperoxidase activity in the lung tissues were measured. The contents of nitrite and nitrate were measured by reduction method, while chemiluminescence was used to determine the content of superoxide. Quantitative real-time polymerase chain reaction and Western blotting were used to determine the expression of mRNA and protein, respectively. Colorimetry was performed to determine the enzymatic activity of heme oxygenase-1 (HO-1). Nuclear translocation of Nrf2 was identified by Western blotting. The plasma contents of cytokines were measured by enzyme-linked immunosorbent assay. Cordycepin enhanced the expression and enzymatic activity of HO-1 in ALI rats, and activated Nrf2 by inducing the translocation of Nrf2 from cytoplasm to nucleus. In addition, cordycepin regulated the secretion of TNF-α, IL-6 and IL-10 via HO-1, and suppressed inflammation in lung tissues of ALI rats by inducing the expression of HO-1. HO-1 played important roles in the down-regulation of superoxide levels in lung tissues by cordycepin, and HO-1 expression induced by cordycepin affected nitrite and nitrate concentrations in plasma and iNOS protein expression in lung tissues. Cordycepin showed protective effect on injuries in lung tissues. The present study demonstrates that cordycepin alleviates inflammation induced by LPS via the activation of Nrf2 and up-regulation of HO-1 expression. Copyright © 2018. Published by Elsevier B.V.

  13. Growth, spectroscopy and laser operation of Ho:KY(WO{sub 4}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Jambunathan, V. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); HiLASE Centre, Institute of Physics ASCR, Za Radnicí 828, 25241 Dolní Břežany (Czech Republic); Mateos, X., E-mail: xavier.mateos@urv.cat [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, 2A Max-Born-Str., D-12489 Berlin (Germany); Loiko, P.A. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Center for Optical Materials and Technologies, Belarusian National Technical University, 65/17 Nezavisimosti Ave., 220013 Minsk (Belarus); Serres, J.M. [Física i Cristallografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcellí Domingo, s/n. E-43007 Tarragona (Spain); Griebner, U.; Petrov, V. [Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, 2A Max-Born-Str., D-12489 Berlin (Germany); Yumashev, K.V. [Center for Optical Materials and Technologies, Belarusian National Technical University, 65/17 Nezavisimosti Ave., 220013 Minsk (Belarus); and others

    2016-11-15

    Monoclinic Ho:KY(WO{sub 4}){sub 2} crystals doped with up to 7.5 at.% Ho are grown by the Top Seeded Solution Growth-Slow Cooling method. The evolution of their unit cell parameters in dependence on the Ho doping and temperature is studied. The polarized low-temperature (6 K) optical absorption of the Ho{sup 3+} ion is investigated in detail to determine the energy of the Stark sub-levels. Room-temperature absorption, stimulated-emission and gain cross-section spectra of Ho:KY(WO{sub 4}){sub 2} crystals are derived for polarizations parallel to the principal optical axes, E||N{sub p}, N{sub m} and N{sub g}. The maximum absorption cross-section for the {sup 5}I{sub 8}→{sup 5}I{sub 7} transition is 1.60×10{sup −20} cm{sup 2} at 1961.0 nm and the maximum stimulated-emission cross-section for the {sup 5}I{sub 7}→{sup 5}I{sub 8} transition is 2.65×10{sup −20} cm{sup 2} at 2056.3 nm (for E||N{sub m}). The radiative lifetime of the upper laser level of the Ho{sup 3+} ion ({sup 5}I{sub 7}) amounts to 4.8 ms. Continuous-wave Ho{sup 3+} laser operation is achieved under in-band pumping by a Tm laser at 1946 nm. In the microchip configuration, the maximum output power reached 205 mW at 2105 nm with a slope efficiency as high as 85%.

  14. Flood-Inundation maps for the Hohokus Brook in Waldwick Borough, Ho-Ho-Kus Borough, and the Village of Ridgewood, New Jersey, 2014

    Science.gov (United States)

    Watson, Kara M.; Niemoczynski, Michal J.

    2015-07-20

    Digital flood-inundation maps for a 6-mile reach of the Hohokus Brook in New Jersey from White's Lake Dam in Waldwick Borough, through Ho-Ho-Kus Borough to Grove Street in the Village of Ridgewood were created by the U.S. Geological Survey (USGS) in cooperation with the New Jersey Department of Environmental Protection. The flood inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Hohokus Brook at Ho-Ho-Kus, New Jersey (station number 01391000). Stage data at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/nwis/uv?site_no=01391000 or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http://water.weather.gov/ahps2/hydrograph.php?gage=hohn4&wfo=okx.

  15. Slaďování pracovního a osobního života pracovníků

    OpenAIRE

    Šauerová, Martina

    2017-01-01

    Diplomová práce se zabývá tématem slaďování pracovního a osobního života ve vybrané společnosti. Práce je rozdělena do tří části – na teoretickou, analytickou a závěrečnou část. Teoretická část vysvětluje atraktivitu a důležitost tohoto tématu, popisuje jednotlivé nástroje umožňující slazení profesního a osobního života a zároveň poukazuje na možné komplikace jednotlivých přístupů, a to jak z pohledu zaměstnavatele, tak i zaměstnance. Analytická část zkoumá a následně vyhodnocuje současný sta...

  16. Návrh raketového motoru

    OpenAIRE

    Cejpek, Jakub

    2009-01-01

    Cílem této práce je navrhnout raketový motor na tuhou pohonnou hmotu s dostatečným výkonem pro vynesení zátěže o hmotnosti 500 gramů do výšky 1500 metrů. A dále navrhnout základní uspořádání rakety, která by tento motor využila. Návrh motoru se řeší nejprve teoreticky. Tedy bez ohledu na dostupnost konstrukčního materiálu, paliva a výrobních technologií. Po vyřešení této teoretické části je na se v řešení zohlední dostupnost výše zmíněných prostředků. To znamená nejprve určit vhodné a dostupn...

  17. Analysis of transients aimed at assessing the feasibility of eliminating the HO-2 accident protection and the ''moderate leak'' SOB signal

    International Nuclear Information System (INIS)

    Sommer, J.

    1993-12-01

    Accidents and transient processes were analyzed in order to assess the feasibility of eliminating the 2nd level accident protection (HO-2). All analyses were performed in 3 alternatives, viz. for the normal performance of HO-2, for the HO-2 signals being transferred to the 1st level accident protection (HO-1), and for a complete elimination of HO-2. Transfer of HO-2 signals to HO-1 definitely brings about an improvement of the nuclear power plant operation safety. There is no evidence indicating that the safety would decrease intolerably if HO-2 were eliminated altogether. Elimination of the ''moderate leak'' safety system does not require any thermohydraulic analysis to be performed. 18 refs

  18. New therapeutic agent for radiation synovectomy - preparation of {sup 166}Ho-EDTMP-HA particle

    Energy Technology Data Exchange (ETDEWEB)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J. [China Institute of Atomic Energy, Beijing (Switzerland). Isotope Department

    1997-10-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with {sup 166}Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, {sup 166}Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free {sup 166}Ho via centrifugation to determine its radiolabelling efficiency. {sup 166}Ho-EDTMP-HA and {sup 166}Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with {sup 166}Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,{mu}m that is suitable for therapy of radiation synovectomy. {sup 166}Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with {sup 166}Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the

  19. New therapeutic agent for radiation synovectomy - preparation of 166Ho-EDTMP-HA particle

    International Nuclear Information System (INIS)

    Bai, H.; Jin, X.; Du, J.; Wang, F.; Chen, D.; Fan, H.; Cheng, Z.; Zhang, J.

    1997-01-01

    In order to prepare new therapeutical agent for radiation synovectomy, Hydroxyapatite (HA) was labelled with 166 Ho by EDTMP that had high affinity to HA particles. Radiolabelling of HA particles was divided into two steps, 166 Ho-EDTMP was prepared first; then mixed with HA particles completely and vibrated for 15 minutes on the micromixer at room temperature, washed 3 times with deionized water. Radiolabelling particle was separated from free 166 Ho via centrifugation to determine its radiolabelling efficiency. 166 Ho-EDTMP-HA and 166 Ho-EDTMP were injected into knee joint of normal rabbits respectively, every group was killed at different time postinjection, took out major organ and collected urine and blood, then weighted and determined their radio counts. HA particles, as a natural component of bone was known to have good compatibility with soft tissue and biodegrade into calcium and phosphate in vivo. It was readily prepared from common chemical and formed into particles of desired size range in a controlled process, it had high stability in vitro and vivo. Radiolabelling of HA particle with 166 Ho by EDTMP was simple to perform and provides an excellent labelling yield that was more than 95% under the optimal labelling condition. The optimal labelling condition at room temperature was pH 6.0-8.0 and vibration time 15 minutes. The absorbed capacity of HA particle was 5 mg Ho/g HA particle and size of radiolabelling particle was at range of 2-5,μm that is suitable for therapy of radiation synovectomy. 166 Ho-EDTMP-HA particle demonstrated high in vitro stability in either normal saline or 1% BSA solution, but instability under extremely acidic condition (pH 1-2). The control studies performed with 166 Ho-EDTMP not bound to HA particle provided information on the distribution of radioactivity that would occur upon leakage of the radiochemical compound from joint. Its short half-life, its extremely low leakage from the joint and its even distribution throughout

  20. Incommensurate magnetic modulations in the magnetic superconductor HoNi2B2C

    International Nuclear Information System (INIS)

    Schneider, M.; Zaharko, O.; Keller, L.; Allenspach, P.; Kreyssig, A.; Canfield, P.C.

    2006-01-01

    Full text: The borocarbide HoNi 2 B 2 C is an unconventional superconductor of particular interest, since long-range magnetism coexists and competes with superconductivity on a common energy range [1]. Our study is based on high quality single crystals of 11 B-substituted HoNi 2 B 2 C. The neutron diffraction investigations are devoted to two issues of specific relevance to HoNi 2 B 2 C. Firstly, the near re-entrant phase between 5K 2 B 2 C is more complicated than proposed so fare [2]. Furthermore we performed a spherical neutron polarimetry experiment to determine the two ICM magnetic structures of HoNi 2 B 2 C and neutron spectroscopy investigations to obtain the microscopic magnetic coupling parameters. All these studies resulted in quite a consistent and complete picture of magnetism in HoNi 2 B 2 C, however, we could not find clear evidence for a strong interaction between superconductivity and magnetism. (author)

  1. Diagnostika diafragmového výboje v kapalinách

    OpenAIRE

    Hlavatá, Lucie

    2009-01-01

    Hlavním cílem této práce je diagnostika diafragmového výboje v kapalinách. Ačkoli byla v posledních letech objevena celá řada aplikací elektrického výboje v kapalinách, vlastní mechanismus vzniku tohoto výboje není dosud znám. Z těchto důvodů se tato práce zaměřila na studium dějů předcházejících samotnému zapálení výboje, zápalného napětí, samotného výboje jak v oblastech náhodného průrazu tak i pravidelnému výboji. Použitím roztoků dvou anorganických solí o různých vodivostech práce zkoumal...

  2. First Calorimetric Measurement of OI-line in the Electron Capture Spectrum of $^{163}$Ho

    CERN Document Server

    Ranitzsch, P. C. -O.; Wegner, M.; Kempf, S.; Fleischmann, A.; Enss, C.; Gastaldo, L.; Herlert, A.; Johnston, K.

    2014-01-01

    The isotope $^{163}$Ho undergoes an electron capture process with a recommended value for the energy available to the decay, $Q_{\\rm EC}$, of about 2.5 keV. According to the present knowledge, this is the lowest $Q_{\\rm EC}$ value for electron capture processes. Because of that, $^{163}$Ho is the best candidate to perform experiments to investigate the value of the electron neutrino mass based on the analysis of the calorimetrically measured spectrum. We present for the first time the calorimetric measurement of the atomic de-excitation of the $^{163}$Dy daughter atom upon the capture of an electron from the 5s shell in $^{163}$Ho, OI-line. The measured peak energy is 48 eV. This measurement was performed using low temperature metallic magnetic calorimeters with the $^{163}$Ho ion implanted in the absorber. We demonstrate that the calorimetric spectrum of $^{163}$Ho can be measured with high precision and that the parameters describing the spectrum can be learned from the analysis of the data. Finally, we dis...

  3. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.

    Science.gov (United States)

    Canuto, Alessandra; Rudhard-Thomazic, Valérie; Herrmann, François R; Delaloye, Christophe; Giannakopoulos, Panteleimon; Weber, Kerstin

    2009-08-15

    To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.

  4. Magnetostriction of Hexagonal HoMnO3 and YMnO3 Single Crystals

    Science.gov (United States)

    Pavlovskii, N. S.; Dubrovskii, A. A.; Nikitin, S. E.; Semenov, S. V.; Terent'ev, K. Yu.; Shaikhutdinov, K. A.

    2018-03-01

    We report on the magnetostriction of hexagonal HoMnO3 and YMnO3 single crystals in a wide range of applied magnetic fields (up to H = 14 T) at all possible combinations of the mutual orientations of magnetic field H and magnetostriction Δ L/L. The measured Δ L/L( H, T) data agree well with the magnetic phase diagram of the HoMnO3 single crystal reported previously by other authors. It is shown that the nonmonotonic behavior of magnetostriction of the HoMnO3 crystal is caused by the Ho3+ ion; the magnetic moment of the Mn3+ ion parallel to the hexagonal crystal axis. The anomalies established from the magnetostriction measurements of HoMnO3 are consistent with the phase diagram of these compounds. For the isostructural YMnO3 single crystal with a nonmagnetic rare-earth ion, the Δ L/L( H, T) dependences are described well by a conventional quadratic law in a wide temperature range (4-100 K). In addition, the magnetostriction effect is qualitatively estimated with regard to the effect of the crystal electric field on the holmium ion.

  5. Optical properties of GaS:Ho3+ and GaS:Tm3+ single crystals

    International Nuclear Information System (INIS)

    Jin, Moon-Seog; Kim, Chang-Dae; Kim, Wha-Tek

    2004-01-01

    GaS:Ho 3+ and GaS:Tm 3+ single crystals were grown by using the chemical transport reaction method. We measured the optical absorption, the infra-red absorption, and the photoluminescence spectra of the single crystals. The direct and the indirect energy band gaps of the single crystals at 13 K were identified. Infra-red absorption peaks at 6 K appeared in the single crystals. Broad emission bands at 6 K were observed at 464 nm and 580 nm for GaS:Ho 3+ and 462 nm and 581 nm for GaS:Tm 3+ . These broad emission bands were identified as originating from donor-acceptor pair recombinations. Sharp emission peak groups were observed near 435 nm, 495 nm, and 660 nm for GaS:Ho 3+ and near 672 nm for GaS:Tm 3+ . These sharp emission peak groups were identified as being due to the electron transitions between the energy levels of Ho 3+ and Tm 3+ . Especially, white photoluminescence was obtained in the GaS:Ho 3+ single crystal.

  6. Hepatitis B Stigma and Knowledge among Vietnamese in Ho Chi Minh City and Chicago

    Directory of Open Access Journals (Sweden)

    Lan Dam

    2016-01-01

    Full Text Available Stigma regarding viral hepatitis and liver disease has psychological and social consequences including causing negative self-image, disrupting relationships, and providing a barrier to prevention, testing, and treatment. The aim of this study was to characterize and compare HBV knowledge and stigma in Vietnamese in Ho Chi Minh City and Chicago and to begin to evaluate the cultural context of HBV stigma. Methods. A written survey including knowledge questions and a validated HBV stigma questionnaire was distributed to Vietnamese in Ho Chi Minh City and Chicago. 842 surveys from Ho Chi Minh City and 170 from Chicago were analyzed. Results. Vietnamese living in Chicago had better understanding of HBV transmission and that HBV can cause chronic infection and liver cancer. Vietnamese in Chicago had higher stigma scores on a broad range of items including guilt and shame about HBV and were more likely to feel that persons with HBV can bring harm to others and should be isolated. Conclusions. Vietnamese in Ho Chi Minh City and Chicago have knowledge deficits about HBV, particularly regarding modes of transmission. Persons in Ho Chi Minh City expressed lower levels of HBV stigma than Vietnamese living in Chicago, likely reflecting changing cultural attitudes in Vietnam. Culturally appropriate educational initiatives are needed to address the problem of HBV stigma.

  7. Spectroscopic investigation of 2.0 μm emission in Ho3+-doped fluoroindate glasses

    International Nuclear Information System (INIS)

    Oliveira, S L; Bell, M J V; Florez, A; Nunes, L A O

    2006-01-01

    In this paper we report the optical characterization of Ho 3+ -doped fluoroindate glasses with the following composition (40 - x)InF 3 -20SrF 2 -16BaF 2 -20ZnF 2 -2GdF 3 -2NaF-xHoF 3 with x = 1.0, 2.0, 2.5, 3.0, 4.0, 5.0, 6.0, 8.0 and 9.0 mol%. This investigation was done by means of absorption, fluorescence and lifetime measurements. The phenomenological intensity parameters Ω λ (λ = 2, 4, 6) were calculated using the standard Judd-Ofelt theory. In order to evaluate potential applications of the 5 I 7 → 5 I 8 Ho 3+ emission at 2.0 μm, the radiative lifetime, total transition rate and emission cross section were determined. The effect of Ho 3+ concentration on the fluorescence intensity and lifetimes was analysed. It was concluded that the non-radiative losses of the 5 I 7 level are mainly due to energy migration among Ho 3+ ions followed by energy transfer to quenching impurities

  8. Clinical Presentation Resembling Mucosal Disease Associated with 'HoBi'-like Pestivirus in a Field Outbreak.

    Science.gov (United States)

    Weber, M N; Mósena, A C S; Simões, S V D; Almeida, L L; Pessoa, C R M; Budaszewski, R F; Silva, T R; Ridpath, J F; Riet-Correa, F; Driemeier, D; Canal, C W

    2016-02-01

    The genus Pestivirus of the family Flaviviridae consists of four recognized species: Bovine viral diarrhoea virus 1 (BVDV-1), Bovine viral diarrhoea virus 2 (BVDV-2), Classical swine fever virus (CSFV) and Border disease virus (BDV). Recently, atypical pestiviruses ('HoBi'-like pestiviruses) were identified in batches of contaminated foetal calf serum and in naturally infected cattle with and without clinical symptoms. Here, we describe the first report of a mucosal disease-like clinical presentation (MD) associated with a 'HoBi'-like pestivirus occurring in a cattle herd. The outbreak was investigated using immunohistochemistry, antibody detection, viral isolation and RT-PCR. The sequence and phylogenetic analysis of 5'NCR, N(pro) and E2 regions of the RT-PCR positive samples showed that four different 'HoBi'-like strains were circulating in the herd. The main clinical signs and lesions were observed in the respiratory and digestive systems, but skin lesions and corneal opacity were also observed. MD characteristic lesions and a pestivirus with cytopathic biotype were detected in one calf. The present study is the first report of a MD like presentation associated with natural infection with 'HoBi'-like pestivirus. This report describes the clinical signs and provides a pathologic framework of an outbreak associated with at least two different 'HoBi'-like strains. Based on these observations, it appears that these atypical pestiviruses are most likely underdiagnosed in Brazilian cattle. © 2014 Blackwell Verlag GmbH.

  9. Identification of Natural Infections in Sheep/Goats with HoBi-like Pestiviruses in China.

    Science.gov (United States)

    Shi, H; Kan, Y; Yao, L; Leng, C; Tang, Q; Ji, J; Sun, S

    2016-10-01

    The natural infections of HoBi-like pestiviruses in cattle have been reported in South America, Europe and Asia. In China, although the detections of HoBi-like pestivirus have been reported, the epidemiological investigation was limited. From January 2014 to October 2015, several flocks of sheep/goats in Henan province in central China suffered respiratory diseases which were recovered slowly after antibiotics treatment. To test whether it is the HoBi-like pestivirus caused this symptom, 49 serum samples and 22 nasal swabs were then collected for analysis by serology and RT-PCR. Serological result revealed that prevalence of pestivirus in small ruminants was 12.2% (6/49) in central China. Sequence analysis of partial 5'-UTR nucleotides of pestivirus-positive samples suggested that HoBi-like pestivirus might have circulated in sheep/goats of China for a period and have evolved into new genotype clusters. It is apparent that the study provides the molecular evidence of natural infections in goat/sheep species with HoBi-like pestiviruses in China. © 2016 Blackwell Verlag GmbH.

  10. Crystal structure of RCoIn5 (R - Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Y) and R2CoIn8 (R - Ce, Pr, Nd, Sm, Gd, Dy, Ho, Er, Tm, Y) compounds

    International Nuclear Information System (INIS)

    Kalychak, Ya.M.; Zaremba, V.I.; Baranyak, V.M.; Bruskov, V.A.; Zavalij, P.Yu.

    1989-01-01

    Usng X-ray diffraction method of monocrystal, crystal structure of HoCoIn 5 compound belonging to the HoCoGa 5 structural type is determined. Using the method of powder belonging of CeCoIn 5 structure to the HoCoGa 5 structural type is confirmed. Isostructural compounds with Y, Pr, Nd, Sm, Gd, Tb, Dy are detected. Their lattice periods are determined. Using the method of powder belonging of Ce 2 CoIn 8 compound structure to Ho 2 CoGa 8 structural type is determined. Isostructural compounds with Y, Pr, Nd, Sm, Gd, Dy, Ho, Er, Tm are detected and their lattice periods are determined

  11. 77 FR 70460 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Ho-Chunk Nation...

    Science.gov (United States)

    2012-11-26

    ... Impact Statement for the Proposed Ho-Chunk Nation Beloit Casino Project, City of Beloit, Rock County, WI...) application for a proposed 33-acre fee-to-trust transfer and casino project to be located in the City of... address, and ``DEIS Scoping Comments, Ho-Chunk Nation Beloit Casino Project'' on the first page of your...

  12. Hydrothermal synthesis of HoMn{sub 2}O{sub 5} nanorods and their size-dependent magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Yichao; Wu, Songping, E-mail: chwsp@scut.edu.cn; Xu, Rui

    2017-03-01

    The HoMn{sub 2}O{sub 5} nanorods were synthesized by a surfactant-assisted hydrothermal process. The length of nanorods is readily controllable with basically constant diameter. HoMn{sub 2}O{sub 5} nanorods show recognizable divagation at T{sub N}(Ho) of 13 K between FC and ZFC curve due to the contribution of the magnetic ordering of holmium. Size-dependent magnetic properties (i.e. a critical length for magnetization) of HoMn{sub 2}O{sub 5} nanorods can be ascribed to the competition between surface strain and uncompensated spin at the surface. - Highlights: • HoMn{sub 2}O{sub 5} nanorods were synthesized by a surfactant-assisted hydrothermal route. • HoMn{sub 2}O{sub 5} nanorods show recognizable divagation at T{sub N}(Ho) of 13 K between FC and ZFC. • Size-dependent magnetic properties of HoMn{sub 2}O{sub 5} nanorods can be observed.

  13. Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

    Science.gov (United States)

    Abraham, Nader G; Quan, Shuo; Mieyal, Paul A; Yang, Liming; Burke-Wolin, Theresa; Mingone, Christopher J; Goodman, Alvin I; Nasjletti, Alberto; Wolin, Michael S

    2002-11-01

    Carbon monoxide (CO) stimulates guanylate cyclase (GC) and increases guanosine 3',5'-cyclic monophosphate (cGMP) levels. We transfected rat-lung pulmonary endothelial cells with a retrovirus-mediated human heme oxygenase (hHO)-1 gene. Pulmonary cells that expressed hHO-1 exhibited a fourfold increase in HO activity associated with decreases in the steady-state levels of heme and cGMP without changes in soluble GC (sGC) and endothelial nitric oxide synthase (NOS) proteins or basal nitrite production. Heme elicited significant increases in CO production and intracellular cGMP levels in both pulmonary endothelial and pulmonary hHO-1-expressing cells. N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NOS, significantly decreased cGMP levels in heme-treated pulmonary endothelial cells but not heme-treated hHO-1-expressing cells. In the presence of exogenous heme, CO and cGMP levels in hHO-1-expressing cells exceeded the corresponding levels in pulmonary endothelial cells. Acute exposure of endothelial cells to SnCl2, which is an inducer of HO-1, increased cGMP levels, whereas chronic exposure decreased heme and cGMP levels. These results indicate that prolonged overexpression of HO-1 ultimately decreases sGC activity by limiting the availability of cellular heme. Heme activates sGC and enhances cGMP levels via a mechanism that is largely insensitive to NOS inhibition.

  14. Mixed phase in cubic and hexagonal HoMn2111Cd PAC and 119Sn, 57Fe Moessbauer studies

    International Nuclear Information System (INIS)

    Cottenier, S.; Meersschaut, J.; Demuynck, S.; Swinnen, B.; Rots, M.

    1998-01-01

    Hyperfine parameters on 57 Fe, 119 Sn and 111 Cd substituted into the Mn sublattice were measured by Moessbauer and PAC spectroscopies. From these results it is tentatively concluded that C15 and C14 HoMn 2 are mixed-phase compounds. In C14 HoMn 2 there is no (or small) moment on the 2a site. (orig.)

  15. Thermoelastic properties of ScB2, TiB2, YB4 and HoB4

    DEFF Research Database (Denmark)

    Waskowska, A.; Gerward, L.; Staun Olsen, J.

    2011-01-01

    (4)GPa). No pressure-induced phase transformations are observed in any of the above borides up to about 20GPa. A continuous temperature-driven orthorhombic distortion is observed for HoB4 below 285K. Values of the thermal expansion coefficient are reported for ScB2 and HoB4 at 293, 200 and 100K...

  16. Antigenic differences between bovine viral diarrhea viruses and HoBi virus: Possible impacts on diagnosis and control

    Science.gov (United States)

    Compare antigenic differences between HoBi virus and BVDV strains that might impact on diagnostics and control. Eighteen non-cytopathic isolates of pestiviruses including the 5 genotypic groups (BVDV1a-c, BVDV2, BDV) and HoBi virus, were tested using antigen capture enzyme-linked immunosorbent assay...

  17. Lack of evidence for the presence of emerging HoBi-like viruses in North American fetal bovine serum lots.

    Science.gov (United States)

    The detection of HoBi-like virus in fetal bovine serum (FBS) labeled as United States of America (USA) origin, but packaged in Europe, raised concerns that HoBi-like virus may have entered the USA. In this study, 90 lots of FBS originating in North America (NA) were screened for pestivirus antigen ...

  18. Standardization Of 166mHo Using Merlin Gerin Ionization Chamber System

    International Nuclear Information System (INIS)

    Nazaroh; Chandra; Hermawan; Juita Erni

    2000-01-01

    Standardization of 166m Ho using Merlin Gerin ionization chamber system has been carried out. Solution of 166m Ho was obtained from ETL-Japan. Activity measurement of 166m Ho was done before and after preparation. The result of activity measurement by P3KRBiN before preparation was (134.47±0.4) kBq/g, and after preparation was (131.98±1.85) kBq/g, at reference time, 1 March 1999. The ETL's result was (130.4±0.4) kBq/g, at the same reference time. The difference between P3KRBiN's (without uncertainty) and ETL's measurement result was 1.2% and if the uncertainty was included, both measurements was agreed

  19. VUV photoionization cross sections of HO2, H2O2, and H2CO.

    Science.gov (United States)

    Dodson, Leah G; Shen, Linhan; Savee, John D; Eddingsaas, Nathan C; Welz, Oliver; Taatjes, Craig A; Osborn, David L; Sander, Stanley P; Okumura, Mitchio

    2015-02-26

    The absolute vacuum ultraviolet (VUV) photoionization spectra of the hydroperoxyl radical (HO2), hydrogen peroxide (H2O2), and formaldehyde (H2CO) have been measured from their first ionization thresholds to 12.008 eV. HO2, H2O2, and H2CO were generated from the oxidation of methanol initiated by pulsed-laser-photolysis of Cl2 in a low-pressure slow flow reactor. Reactants, intermediates, and products were detected by time-resolved multiplexed synchrotron photoionization mass spectrometry. Absolute concentrations were obtained from the time-dependent photoion signals by modeling the kinetics of the methanol oxidation chemistry. Photoionization cross sections were determined at several photon energies relative to the cross section of methanol, which was in turn determined relative to that of propene. These measurements were used to place relative photoionization spectra of HO2, H2O2, and H2CO on an absolute scale, resulting in absolute photoionization spectra.

  20. House of Quality (HoQ) as a tool for improvement customer satisfaction

    International Nuclear Information System (INIS)

    Fazila Said; Noriah Mod Ali; Siti Mariam Ibrahim

    2010-01-01

    Full-text: Improvements to the customer satisfaction level is an important agenda today for the preservation of a quality certification. This study shows where the critical attributes or Voice of Customers, VOC-interest analysis of the results of Importance Performance Analysis (IPA). Questionnaires from our four customer service centers at Malaysian Nuclear Agency has been used in developing the House of Quality (HoQ). The innovation of HoQ is one of the simple and attractive services that display comprehensive information covering the needs of customers (VOC), the technical response, the correlation of technical, communication matrix, technical and planning division. Therefore, the information obtained from HoQ can be used in assisting the top management planning in accordance with the priority improvement activities to improve customer satisfaction levels in the near future. (author)

  1. Development of radioactive 166Ho-coated balloon and its dose estimation

    International Nuclear Information System (INIS)

    Park, K. B.; Kim, K. H.; Hong, Y. D.; Park, E. W.

    2000-01-01

    The use of balloon with radioisotope is a promising method to prevent restenosis after transluminal coronary arterial angioplasty or stent implantation. In this study, we have developed a new radioactive coated balloon, which is prepared by coating the surface of existing balloon with 166 Ho instead of being filled with beta sources which emit high energy beta-particles for the purpose of the delivery of sufficient radiation to the vessel wall. To estimate the safety of 166 Ho-coated balloon, leaching test and radiation resistance test of the balloon were performed. The absorbed dose distributions around the 166 Ho-coated balloon were estimated by means of Monte Carlo simulation and the initial activities for optimal therapeutic regimen were determined on the basis of this results

  2. Pohon pásového dopravníku pro transport uhlí

    OpenAIRE

    Kliš, Kamil

    2013-01-01

    Diplomová práce se zabývá návrhem pohonu pásového dopravníku pro transport uhlí. Práce obsahuje nezbytné výpočty dle norem potřebné k určení vhodných komponentů pásového dopravníku. Cílem diplomové práce bylo navrhnout pohon pásového dopravníku, všech jeho potřebných komponentů včetně návrhem rámu pohonu a vytvoření výkresové dokumentace. This diploma thesis deals with designing a drivetrain for a coal belt conveyor. Thesis contains necessary calculations according to norms needed for dete...

  3. Podnikatelský plán výrobního podniku

    OpenAIRE

    Borovská, Veronika

    2010-01-01

    V této diplomové práci je zpracován podnikatelský záměr výrobního podniku. Na základě teoretických poznatků získaných během studií a zjištěných skutečností, obsahuje návrh založení firmy a jejího případného umístění na trhu. This master’s thesis deals with business plan of production company. Based on the theoretical pieces of knowledges acquired during studies and discovered facts, it contains the proposal of establishment of the company and its conceivable positioning on the market. A...

  4. Magnetic properties of HoVOΛ4 in high magnetic fields

    International Nuclear Information System (INIS)

    Andronenko, S.I.; Bazhan, A.N.; Ioffe, V.A.; Udalov, Yu.P.

    1985-01-01

    Values magnetization and susceptibility of HoVO 4 , Van Vleck paramagnetic are specified in the 4.2-40 K temperature range and magnetic fields up to 50 kOe. Magnetic properties of HoVO 4 are analyzed using a theoretical model in which the interaction of rare earth ions with the crystal- and magnetic fields is considered. A possibility of rare earth ion interaction with the Bsub(1g), Bsub(2g), Asub(1g) symmetry deformations is also considered. It is stated that magnetic properties of HoVO 4 are completely explained within the frames of the crystal field model; the rare earth ion interactions with deformations are insignificant. Anisotropy of magnetization in the (001) plane is determined by the crystal field B 4 4 , B 6 4 constants; the constants being shown to be positive

  5. Momentum and charge transport in non-relativistic holographic fluids from Hořava gravity

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Richard A. [Department of Physics, Harvard University, Cambridge, MA 02138 (United States); Grozdanov, Sašo [Instituut-Lorentz for Theoretical Physics, Leiden University, Niels Bohrweg 2, Leiden 2333 CA (Netherlands); Janiszewski, Stefan [Department of Physics and Astronomy, University of Victoria, Victoria, BC, V8W 3P6 (Canada); Kaminski, Matthias [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States)

    2016-11-28

    We study the linearized transport of transverse momentum and charge in a conjectured field theory dual to a black brane solution of Hořava gravity with Lifshitz exponent z=1. As expected from general hydrodynamic reasoning, we find that both of these quantities are diffusive over distance and time scales larger than the inverse temperature. We compute the diffusion constants and conductivities of transverse momentum and charge, as well the ratio of shear viscosity to entropy density, and find that they differ from their relativistic counterparts. To derive these results, we propose how the holographic dictionary should be modified to deal with the multiple horizons and differing propagation speeds of bulk excitations in Hořava gravity. When possible, as a check on our methods and results, we use the covariant Einstein-Aether formulation of Hořava gravity, along with field redefinitions, to re-derive our results from a relativistic bulk theory.

  6. Koncepce tlačítkového piezo-generátoru

    OpenAIRE

    Kučera, David

    2012-01-01

    Tato bakalářská práce se zabývá koncepcí tlačítkového piezo-generátoru. V práci jsou popsány typy piezo-generátorů, vysvětlen piezoelektrický jev, typy piezoelektrických materiálů se zaměřením na piezokeramiku. Dále jsou popsány materiálové vlastnosti piezoelektrických keramik. Na konci práce je popsán návrh samotného tlačítkového piezo-generátoru. This bachelor’s thesis deals with proposal of piezo-generator inside button. There are described types of piezo-generators, explained piezoelec...

  7. Zvýšení ročního využití parního práškového kotle K5 ve ŽĎAS, a. s

    OpenAIRE

    Kubiš, David

    2017-01-01

    Tato diplomová práce se zabývá vyšším využitím kotle K5 v teplárně ŽĎAS, a.s. v přechodném období, kdy vlivem snížených odběrů dochází k přehřívání zpáteční větve horkovodu a je nutnost přejíždět na jiný kotel. Cílem práce je omezit přejíždění z kotle K5 na kotel K3 a zvýšit jeho časové využití v přechodném období pomocí ekonomicky únosného technického řešení. Na začátku práce je popsána teplárna ŽĎAS, a.s. a její vybavení. Následují čtyři metody výpočtů zvýšení ročního využití kotle K5. A to...

  8. Single crystal polarized neutron diffraction study of the magnetic structure of HoFeO3.

    Science.gov (United States)

    Chatterji, T; Stunault, A; Brown, P J

    2017-09-27

    Polarised neutron diffraction measurements have been made on HoFeO 3 single crystals magnetised in both the [0 0 1] and [1 0 0] directions (Pbnm setting). The polarisation dependencies of Bragg reflection intensities were measured both with a high field of [Formula: see text] T parallel to [0 0 1] at [Formula: see text] K and with the lower field [Formula: see text] T parallel to [1 0 0] at [Formula: see text] K. A Fourier projection of magnetization induced parallel to [0 0 1], made using the hk0 reflections measured in 9 T, indicates that almost all of it is due to alignment of Ho moments. Further analysis of the asymmetries of general reflections in these data showed that although, at 70 K, 9 T applied parallel to [0 0 1] hardly perturbs the antiferromagnetic order of the Fe sublattices, it induces significant antiferromagnetic order of the Ho sublattices in the [Formula: see text] plane, with the antiferromagnetic components of moment having the same order of magnitude as the induced ferromagnetic ones. Strong intensity asymmetries measured in the low temperature [Formula: see text] structure with a lower field, 0.5 T [Formula: see text] [1 0 0] allowed the variation of the ordered components of the Ho and Fe moments to be followed. Their absolute orientations, in the [Formula: see text] domain stabilised by the field were determined relative to the distorted perovskite structure. This relationship fixes the sign of the Dzyalshinski-Moriya (D-M) interaction which leads to the weak ferromagnetism. Our results indicate that the combination of strong y-axis anisotropy of the Ho moments and Ho-Fe exchange interactions breaks the centrosymmetry of the structure and could lead to ferroelectric polarization.

  9. 2363-IJBCS-Article-Kouadio Nguessan Jules

    African Journals Online (AJOL)

    hp

    Available online at http://ajol.info/index.php/ijbcs ... Evaluation de l'activité des feuilles de Mallotus oppositifolius (Geisel.) ... 3 Centre Suisse de Recherche Scientifique en Côte d'Ivoire, Côte d'Ivoire. ... hydro-méthanolique et aqueux des feuilles de cette plante sur des bactéries .... Le support bactérien était composé de.

  10. 407-IJBCS-Article- Ngueguim Jules R

    African Journals Online (AJOL)

    Dr GATSING

    2011 International Formulae Group. All rights ... principaux marchés de forêt dense humide du. Cameroun ... modes d'appropriation de l'arbre. Cela affecte particulièrement les familles rurales qui ont déjà du mal à .... rend leur accès facile.

  11. 2342-IJBCS-Article-Ngueguim Jules Roger

    African Journals Online (AJOL)

    hp

    4Institut de la Recherche Agricole pour le Développement (IRAD), Yokadouma, Cameroun. 5Departement ..... définition, le premier quartile, d'une série ordonnée ..... le site. Structure de population. Les structures de population présentent la répartition des arbres en fonction de leur taille dans un peuplement. Ces outils sont.

  12. 2363-IJBCS-Article-Kouadio Nguessan Jules

    African Journals Online (AJOL)

    hp

    de santé publique à cause de leur fréquence et de leur gravité. En effet, elles sont à l'origine de plus de 17 millions de décès par an dans le monde dont plus de la moitié provient du seul continent africain (OMS, 2006). Ainsi, la découverte des antibiotiques a été un véritable soulagement pour l'humanité car ces remèdes ...

  13. 2343-IJBCS-Article-Ngueguim Jules Roger

    African Journals Online (AJOL)

    hp

    4University of Ngaoundéré, Faculty of Science, Department of Biological ... de Paris (MNHN) and the Service d'Action Culturelle of France Embassy in ..... management may allow plantations to ... JRN initiated the research project, did the data ...

  14. Heme oxygenase-1 (HO-1 expression in prostate cancer cells modulates the oxidative response in bone cells.

    Directory of Open Access Journals (Sweden)

    Mercedes Ferrando

    Full Text Available Prostate cancer (PCa is a leading cause of death among males. It is currently estimated that inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. PCa is dominated by complications arising from metastasis to the bone where the tumor cells interact with the bone microenvironment impairing the balance between bone formation and degradation. However, the molecular nature of this interaction is not completely understood. Heme oxygenase-1 (HO-1 counteracts oxidative damage and inflammation. Previous studies from our laboratory showed that HO-1 is implicated in PCa, demonstrating that endogenous HO-1 inhibits bone derived-prostate cancer cells proliferation, invasion and migration and decreases tumor growth and angiogenesis in vivo. The aim of this work was to analyze the impact of HO-1 modulated PCa cells on osteoblasts proliferation in vitro and on bone remodeling in vivo. Using a co-culture system of PC3 cells with primary mice osteoblasts (PMOs, we demonstrated that HO-1 pharmacological induction (hemin treatment abrogated the diminution of PMOs proliferation induced by PCa cells and decreased the expression of osteoclast-modulating factors in osteoblasts. No changes were detected in the expression of genes involved in osteoblasts differentiation. However, co-culture of hemin pre-treated PC3 cells (PC3 Hem with PMOs provoked an oxidative status and activated FoxO signaling in osteoblasts. The percentage of active osteoblasts positive for HO-1 increased in calvarias explants co-cultured with PC3 Hem cells. Nuclear HO-1 expression was detected in tumors generated by in vivo bone injection of HO-1 stable transfected PC3 (PC3HO-1 cells in the femur of SCID mice. These results suggest that HO-1 has the potential to modify the bone microenvironment impacting on PCa bone metastasis.

  15. Hořava Gravity is Asymptotically Free in 2+1 Dimensions.

    Science.gov (United States)

    Barvinsky, Andrei O; Blas, Diego; Herrero-Valea, Mario; Sibiryakov, Sergey M; Steinwachs, Christian F

    2017-11-24

    We compute the β functions of marginal couplings in projectable Hořava gravity in 2+1 spacetime dimensions. We show that the renormalization group flow has an asymptotically free fixed point in the ultraviolet (UV), establishing the theory as a UV-complete model with dynamical gravitational degrees of freedom. Therefore, this theory may serve as a toy model to study fundamental aspects of quantum gravity. Our results represent a step forward towards understanding the UV properties of realistic versions of Hořava gravity.

  16. Cosmological perturbations in the projectable version of Hořava-Lifshitz gravity

    International Nuclear Information System (INIS)

    Cerioni, Alessandro; Brandenberger, Robert H.

    2011-01-01

    We consider linear perturbations about a homogeneous and isotropic cosmological background in the projectable version of Hořava-Lifshitz gravity. Starting from the action for cosmological perturbations, we identify the canonically normalized fluctuation variables. We find that - in contrast to what happens in the non-projectable version of the theory - the extra scalar cosmological perturbation mode is already dynamical at the level of linear perturbations and is either ghost-like or tachyonic depending on the value of a free parameter. This indicates a problem for the projectable version of Hořava-Lifshitz gravity

  17. {sup 166} Ho-EDTMP in detecting bone metastases: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Achando, S.S.; Fernandes, L.; Herrerias, R.; Muramoto, E.; Almeida, M.A.T.; Pereira, N.S. de; Mengatti, J. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1995-12-31

    Holmium-166-EDTMP (ethylene-dimine-tetra methylene phosphonic acid) due to its promising biological properties, has proved to be a palliating therapeutic agent for bone cancer in human beings. In a basic medium, {sup 166} Ho-EDTMP can be readily prepared with a complexing molar ratio EDTMP/Ho 4.34. The radiochemical purity of the complex was higher than 98%. The biodistribution in rats and mice, showed a high skeletal uptake, a fast blood clearance and a low soft tissue uptake and a lesion to normal bone ratio equal to 2. (author). 3 refs., 4 tabs.

  18. Magnetic and Moessbauer studies of amorphous Fe72-xYxHo8B20 alloys

    International Nuclear Information System (INIS)

    Krishnan, R.; Dumond, Y.; Ajan, A.; Shringi, S.N.; Prasad, S.

    1996-01-01

    We have carried out magnetic and Moessbauer studies of amorphous Fe 72-x Y x Ho 8 B 20 alloys. The Fe moment decreases with the addition of Y and a magnetic compensation occurs at 4 K for x=16. The temperature and field dependences of the magnetization have been interpreted using the mean field theory and Chudnovsky's model, respectively. These analyses yield some interesting parameters such as the random anisotropy, the exchange interactions J Fe-Fe , J Fe-Ho , etc. The Moessbauer studies show that the average hyperfine field decreases linearly with the addition of Y, in accordance with the decrease in the Fe moment. (orig.)

  19. Preparation, characterization and luminescence of nanocrystalline Y2O3:Ho

    International Nuclear Information System (INIS)

    Biljan, Tomislav; Gajovic, Andreja; Meic, Zlatko; Mestrovic, Ernest

    2007-01-01

    Nanocrystalline Y 2 O 3 :Ho was synthesized by solution combustion method with ethylene glycol as fuel. Material was characterized using powder X-ray diffraction and transmission electron microscopy (TEM). X-ray diffraction and TEM showed that the material is nanostructured. Luminescence properties were studied using Raman spectrometers with excitation in near infrared (NIR) and visible regions. The visible and NIR luminescence spectra of nanocrystalline Y 2 O 3 :Ho show some important differences from those of bulk material. The convenience of using Raman instruments for studying luminescence of lanthanide ions is demonstrated

  20. Radiolytic oxidation of tamoxifen using the free radicals .OH and (or) HO2

    International Nuclear Information System (INIS)

    Leguene, C.; Clavere, P.; Jore, D.; Gardes-Albert, M.

    2001-01-01

    Tamoxifen is the most widely used antiestrogen in the treatment of breast cancer. In this work, we have studied its antioxidant properties. We have investigated the ability of tamoxifen to scavenge, in vitro, . OH and (or) HO 2 . free radicals that are produced by water radiolysis. Aqueous solutions of tamoxifen of concentrations ranging between 10 -5 and 2.5 x 10 -5 M have been irradiated (γ 137 Cs) in aerated acidic medium (H 3 PO 4 10 -3 M or HCOOH 10 -1 M). The results show that tamoxifen reacts quantitatively with . OH free radicals but does not react with HO 2 . free radicals under our experimental conditions. (author)

  1. Knudsen cell vaporization of rare earth nitrides: enthalpy of vaporization of HoN098

    International Nuclear Information System (INIS)

    Brown, R.C.; Clark, N.J.

    1975-01-01

    The enthalpy of vaporization of HoN 0 . 98 was measured by the weight-loss Knudsen cell technique using Motzfeldt-Whitman extrapolations to zero orifice area. A third-law enthalpy of vaporization of HoN 0 . 98 of 155.9 +- 5 kcal mole -1 was obtained compared to a second-law value of 162.0 +- 5 kcal mole -1 . Similar measurements on the nitrides of samarium, erbium, and ytterbium gave third-law enthalpies of vaporization of 126.8 +-- 5 kcal mole -1 ; 159.6 +- 5 kcal mole -1 , and 121.0 +- 5 kcal mole -1 , respectively. 7 tables

  2. MASJID JAMI PITI LAKSAMANA MUHAMMAD CHENG HO PURBALINGGA: SIMBOL KEINDAHAN TOLERANSI DALAM AKULTURASI

    Directory of Open Access Journals (Sweden)

    Dinda Wulan Afriani

    2015-10-01

    terletak di Kabupaten Purbalingga, Jawa Tengah. Masjid Laksamana Muhammad Cheng Ho Purbalingga merupakan salah satu dari tiga masjid Cheng Ho di Indonesia. Kehadiran masjid ini merupakan wujud simbol keindahan toleransi antar etnis dan budaya dalam sebuah akulturasi. Bentuk arsitektur masjid ini merupakan perpaduan dari budaya Islam- Tiongkok-Arab-Jawa. Keistimewaan masjid ini bukan hanya terletak pada bentuk arsitektur bangunan dan ragam hias arsitekturnya saja. Namun juga pada keindahan makna dan nilai falsafah kehidupan yang terkandung di dalamnya, yang tentu saja selaras dengan peran sertanya dalam masyarakat. Dalam membaca tanda dan makna, artikel ini juga menyajikan penalaran melalui metode semiotika visual secara singkat namun cukup padat.

  3. Electronic absorption bands of HoCl3 and SmCl3 complexes in alcohols

    International Nuclear Information System (INIS)

    Ramesh Babu, V.; Buddhudu, S.; Rangarajan, V.N.

    1987-01-01

    The normal absorption and second derivative spectra of ten alcoholic complexes of HoCl 3 and SmCl 3 were recorded. From the observed bands, energies and intensity values were measured. To fit in these measured values with the theoretical values, a set of spectroscopic parameters namely, Judd-Ofelt (T 2 , T 4 , T 6 ), intensity (Ω 2 , Ω 4 , Ω 6 ) had been computed. A good fit of intensities was obtained between the experimental and theoretical data. The environmental influences on the intensities of the hypersensitive transitions of Sm(III) and Ho(III) ions were found to be noteworthy. (author). 7 tables, 20 refs

  4. Magnetic properties of a HoCo10Ti2 single crystal

    International Nuclear Information System (INIS)

    Janssen, Y.; Tegus, O.; Klaasse, J.C.P.; Brueck, E.; Buschow, K.H.J.; Boer, F.R. de

    2001-01-01

    The magnetic properties of single-crystalline easy-axis ThMn 12 -type ferrimagnetic HoCo 10 Ti 2 have been studied. At 4.2 K, the magnetization process with the field applied along the easy c-axis is completely different from that, with the field applied perpendicular to it. The bending process of the initially antiparallel Ho and Co magnetic moments, that is observed in the latter measurement, is briefly described in terms of mean-field theory. Furthermore, when the field is applied in the hard magnetization direction, the bending process has directly been observed by means of measurement of the transversal magnetization

  5. Neutronics experimental validation of the Jules Horowitz reactor fuel by interpretation of the VALMONT experimental program-transposition of the uncertainties on the reactivity of JHR with JEF2.2 and JEFF3.1.1

    International Nuclear Information System (INIS)

    Leray, O.; Hudelot, J.P.; Doederlein, C.; Vaglio-Gaudard, C.; Antony, M.; Santamarina, A.; Bernard, D.

    2012-01-01

    The new European material testing Jules Horowitz Reactor (JHR), currently under construction in Cadarache center (CEA France), will use LEU (20% enrichment in 235 U) fuels (U 3 Si 2 for the start up and UMoAl in the future) which are quite different from the industrial oxide fuel, for which an extensive neutronics experimental validation database has been established. The HORUS3D/N neutronics calculation scheme, used for the design and safety studies of the JHR, is being developed within the framework of a rigorous verification-numerical validation-experimental validation methodology. In this framework, the experimental VALMONT (Validation of Aluminium Molybdenum uranium fuel for Neutronics) program has been performed in the MINERVE facility of CEA Cadarache (France), in order to qualify the capability of HORUS3D/N to accurately calculate the reactivity of the JHR reactor. The MINERVE facility using the oscillation technique provides accurate measurements of reactivity effect of samples. The VALMONT program includes oscillations of samples of UAl ∞ /Al and UMo/Al with enrichments ranging from 0.2% to 20% and Uranium densities from 2.2 to 8 g/cm 3 . The geometry of the samples and the pitch of the experimental lattice ensure maximum representativeness with the neutron spectrum expected for JHR. By comparing the effect of the sample with the one of a known fuel specimen, the reactivity effect can be measured in absolute terms and be compared to computational results. Special attention was paid to the rigorous determination and reduction of the experimental uncertainties. The calculational analysis of the VALMONT results was performed with the French deterministic code APOLLO2. A comparison of the impact of the different calculation methods, data libraries and energy meshes that were tested is presented. The interpretation of the VALMONT experimental program allowed the experimental validation of JHR fuel UMoAl8 (with an enrichment of 19.75% 235 U) by the Minerve

  6. Automatická segmentace periodického pohybu srdečního svalstva v EKG záznamu

    OpenAIRE

    Matocha, Petr

    2015-01-01

    Tato práce se zabývá automatickou segmentací periodického pohybu srdečního svalstva v EKG záznamu. Popisuje návrh a implementaci aplikace, jenž automaticky segmentuje EKG záznam na jednotlivé srdeční stahy. EKG záznam je uložen samostatně nebo je součástí videozáznamu. Tyto vstupní data jsou uložena v souborech ve formátu HDF nebo DICOM. This thesis deals with the automatic segmentation of the cardiac tissue movement from ECG record. It describes the design and implementation of applicatio...

  7. Návrh týmového motivačního programu ve firmě FlatEarth

    OpenAIRE

    Lukaniaková, Nina

    2010-01-01

    Diplomová práca sa zameriava na vytvorenie návrhu motivačného program v spoločnosti FlatEarth. Návrh tohoto programu sa odvíja od výsledkov výskumu uskutočneného v športových teamoch a medzi bývalými zamestnancami spoločnosti FlatEarth. The diploma thesis concentrates on the presentation of motivational programme in the company of our choice- FlatEarth. The suggestion of the motivational programme is based on the results from research conducted in the sport teams and among previous employe...

  8. The HoMBReS and HoMBReS Por un Cambio Interventions to Reduce HIV Disparities Among Immigrant Hispanic/Latino Men.

    Science.gov (United States)

    Rhodes, Scott D; Leichliter, Jami S; Sun, Christina J; Bloom, Fred R

    2016-02-12

    Hispanics/Latinos in the United States are affected disproportionately by human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and other sexually transmitted diseases (STDs); however, few effective evidence-based prevention interventions for this population exist. This report describes the Hombres Manteniendo Bienestar y Relaciones Saludables (Men Maintaining Wellbeing and Healthy Relationships) (HoMBReS) intervention, which was developed by a community-based, participatory research partnership in North Carolina and initially implemented during 2005-2009. HoMBReS is an example of an effective intervention that uses lay health advisors (known as Navegantes [navigators]) in the context of existing social networks (i.e., recreational soccer teams) to promote consistent condom use and HIV and STD testing among Hispanic/Latino men. In 2012, HoMBReS was classified as a best-evidence community-level HIV prevention intervention (CDC. Compendium of evidence-based behavioral interventions and best practices for HIV prevention. Atlanta, GA: US Department of Health and Human Services, CDC; 2015). The intervention has been implemented elsewhere, enhanced, and further evaluated in longitudinal intervention and implementation studies. HoMBReS has been adapted for other populations, including men who have sex with men and transgender persons. Additional evaluation has found that Navegantes continue in their roles as health advisors, opinion leaders, and community advocates after study support ends. Hispanic/Latino men's social networks can be leveraged to promote sexual health within the community by decreasing HIV risk behaviors among Hispanics/Latinos in the United States.

  9. The HoMBReS and HoMBReS Por un Cambio Interventions to Reduce HIV Disparities Among Immigrant Hispanic/Latino Men

    OpenAIRE

    Rhodes, Scott D.; Leichliter, Jami S.; Sun, Christina J.; Bloom, Fred R.

    2016-01-01

    Hispanics/Latinos in the United States are affected disproportionately by human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and other sexually transmitted diseases (STDs); however, few effective evidence-based prevention interventions for this population exist. This report describes the Hombres Manteniendo Bienestar y Relaciones Saludables (Men Maintaining Wellbeing and Healthy Relationships) (HoMBReS) intervention, which was developed by a community-bas...

  10. TRAPPING HO2 FREE RADICAL IN SONICATED WATER%空化水中HO2自由基的捕获

    Institute of Scientific and Technical Information of China (English)

    刘岩; 王军

    2003-01-01

    @@ 1 INTRODUCTION As a new advanced oxidation process (AOP) in water treatment, sonochemistry in water treatment has been paid more attention for one decade[1-7]. The collapsed cavitation bubbles give rise to high temperature and high pressure[8] to generate free radical, e.g. OH, O, HO2 in sonicated water. These kinds of radicals can oxidize the organic substances dissolved in water.

  11. Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase.

    Science.gov (United States)

    Wilks, A; Black, S M; Miller, W L; Ortiz de Montellano, P R

    1995-04-04

    A human heme oxygenase (hHO-1) gene without the sequence coding for the last 23 amino acids has been expressed in Escherichia coli behind the pho A promoter. The truncated enzyme is obtained in high yields as a soluble, catalytically-active protein, making it available for the first time for detailed mechanistic studies. The purified, truncated hHO-1/heme complex is spectroscopically indistinguishable from that of the rat enzyme and converts heme to biliverdin when reconstituted with rat liver cytochrome P450 reductase. A self-sufficient heme oxygenase system has been obtained by fusing the truncated hHO-1 gene to the gene for human cytochrome P450 reductase without the sequence coding for the 20 amino acid membrane binding domain. Expression of the fusion protein in pCWori+ yields a protein that only requires NADPH for catalytic turnover. The failure of exogenous cytochrome P450 reductase to stimulate turnover and the insensitivity of the catalytic rate toward changes in ionic strength establish that electrons are transferred intramolecularly between the reductase and heme oxygenase domains of the fusion protein. The Vmax for the fusion protein is 2.5 times higher than that for the reconstituted system. Therefore, either the covalent tether does not interfere with normal docking and electron transfer between the flavin and heme domains or alternative but equally efficient electron transfer pathways are available that do not require specific docking.

  12. Neutron depolarization measurements of HoCo2 near the magnetic phase transition

    International Nuclear Information System (INIS)

    Kraan, W.

    1976-09-01

    The magnetic phase transition in HoCo 2 at zero applied field is investigated. The Landau theory of magnetic phase transition is discussed. The experimental technique for neutron depolarization measurements in the temperature range 65-90 K is described

  13. Návrh podnikatelského záměru

    OpenAIRE

    Lanc, Martin

    2009-01-01

    Cílem této diplomové práce je definovat podnikatelský záměr konkrétního malého podniku a následně ho zpracovat do podoby podnikatelského plánu. Tento záměr bude sloužit jako podklad pro realizaci soukromé mateřské školy. Diplomová práce obsahuje teoretickou část, analýzu problému včetně zákonných podmínek zřízení a provozu firmy, konečně i marketingové analýzy a finanční plán. Závěr práce se věnuje celkovému shrnutí výsledků a možnostech rozvoje. The subject diploma thesis “Proposal for a ...

  14. Diode-pumped efficient laser operation and spectroscopy of Tm,Ho:YVO 4

    Science.gov (United States)

    Li, G.; Yao, B. Q.; Meng, P. B.; Duan, X. M.; Ju, Y. L.; Wang, Y. Z.

    2011-04-01

    Spectroscopic characterization of co-doped Tm,Ho:YVO 4 crystal grown by the Czochralski method has been performed including absorption spectrum, emitting spectrum and luminescence decay lifetime. The polarization emitting spectrum around 2 μm is accomplished by exciting a singly Ho 3+ doped YVO 4 crystal to exclude the influence of Tm 3+3F 4- 3H 6 transition and the emission cross section is deduced from both Fuchtbauer-Ladenburg (F-L) equation and reciprocity method (RM). In addition, we report up to 10.4 W continuous wave (CW) output with a conversion efficiency of 40% and 10.3 W Q-Switch output with 12.5 kHz pulse repetition rate of diode-pumped cryogenic Tm,Ho:YVO 4 laser. For Q-Switch operation, the minimum pulse width of 28.2 ns is obtained, all of which demonstrate that the Tm,Ho:YVO 4 is excellent laser material for 2 μm radiation.

  15. Radiochemical research and education program at the TU in Ho-Chi-Minh City

    International Nuclear Information System (INIS)

    Ngo Manh Thang

    2016-01-01

    In the first part of this presentation a review of studying programmes at the Ho-Chi-Minh City University of Technology as well as international co-operation is discussed. In the second part the results of gamma radiation induced radiolysis of sulfamethoxazole aqueous solutions are presented.

  16. Critical behavior of the magnetic susceptibility of the uniaxial ferromagnet LiHoF4

    DEFF Research Database (Denmark)

    Beauvillain, P.; Renard, J. P.; Laursen, Ib

    1978-01-01

    The magnetic susceptibility of two LiHoF4 single crystals has been measured in the range 1.2-4.2 K. Ferromagnetic order occurs at Tc=1.527 K. Above 2.5 K, the susceptibilities parallel and perpendicular to the fourfold c axis are well interpreted by the molecular-field approximation, taking...

  17. Three-dimensional magnetization process in HoFe.sub.11./sub.Ti

    Czech Academy of Sciences Publication Activity Database

    Janssen, Y.; Klaasse, J. C. P.; Brück, E.; De Boer, F. R.; Buschow, K. H. J.; Kamarád, Jiří; Kudrevatykh, N. V.

    2002-01-01

    Roč. 319, - (2002), s. 59-72 ISSN 0921-4526 Institutional research plan: CEZ:AV0Z1010914 Keywords : HoFe 11 Ti * magnetic anisotropy * magnetization processes * magnetization rotation * rare- earth -transition-metal compounds Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.609, year: 2002

  18. Preparation and Quality Control of 166Ho Labelled Polylactic Acid Microspheres for radiotherapy

    Czech Academy of Sciences Publication Activity Database

    Kropáček, Martin; Melichar, František; Klejzarová, Michaela; Ventruba, Jiří; Tomeš, Marek; Mirzajevová, Marcela

    2007-01-01

    Roč. 2, č. 332 (2007), s. 34-34 ISSN 1619-7070 R&D Projects: GA AV ČR 1QS100480501 Institutional research plan: CEZ:AV0Z10480505 Keywords : polylactic acid microspheres * 166Ho * liver tumour therapy Subject RIV: FR - Pharmacology ; Medidal Chemistry

  19. Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway

    Directory of Open Access Journals (Sweden)

    Chao He

    2018-01-01

    Full Text Available Septic myocardial dysfunction remains prevalent and raises mortality rate in patients with sepsis. During sepsis, tissues undergo tremendous oxidative stress which contributes critically to organ dysfunction. Edaravone, a potent radical scavenger, has been proved beneficial in ischemic injuries involving hypoxia-inducible factor- (HIF- 1, a key regulator of a prominent antioxidative protein heme oxygenase- (HO- 1. However, its effect in septic myocardial dysfunction remains unclarified. We hypothesized that edaravone may prevent septic myocardial dysfunction by inducing the HIF-1/HO-1 pathway. Rats were subjected to cecal ligation and puncture (CLP with or without edaravone infusion at three doses (50, 100, or 200 mg/kg, resp. before CLP and intraperitoneal injection of the HIF-1α antagonist, ME (15 mg/kg, after CLP. After CLP, rats had cardiac dysfunction, which was associated with deformed myocardium, augmented lipid peroxidation, and increased myocardial apoptosis and inflammation, along with decreased activities of catalase, HIF-1α, and HO-1 in the myocardium. Edaravone pretreatment dose-dependently reversed the changes, of which high dose most effectively improved cardiac function and survival rate of septic rats. However, inhibition of HIF-1α by ME demolished the beneficial effects of edaravone at high dose, reducing the survival rate of the septic rats without treatments. Taken together, edaravone, by inducing the HIF-1α/HO-1 pathway, suppressed oxidative stress and protected the heart against septic myocardial injury and dysfunction.

  20. Radiosynoviorthesis of Knees by Means of 166Ho-Holmium-Boro-Macroaggregates

    Czech Academy of Sciences Publication Activity Database

    Kraft, O.; Kašpárek, R.; Ullmann, V.; Melichar, František; Kropáček, Martin; Mirzajevová, Marcela

    2007-01-01

    Roč. 22, č. 2 (2007), s. 296-302 ISSN 1084-9785 R&D Projects: GA AV ČR 1QS100480501 Institutional research plan: CEZ:AV0Z10480505 Keywords : radiosynoviorthesis * radionuclide synovectomy * 166Ho Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 1.725, year: 2007

  1. Clinical presentation resembling mucosal disease associated with 'HoBi'-like pestivirus in a field outbreak

    Science.gov (United States)

    The genus Pestivirus of the family Flaviviridae consists of four recognized species: Bovine viral diarrhea virus 1 (BVDV-1), Bovine viral diarrhea virus 2 (BVDV-2), Classical swine fever virus (CSFV) And Border disease virus (BDV). Recently, atypical pestiviruses (‘HoBi’-like pestiviruses) were iden...

  2. Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress.

    Science.gov (United States)

    Jung, Tae Woo; Kim, Hyung-Chun; Abd El-Aty, A M; Jeong, Ji Hoon

    2017-06-01

    Several studies have shown that protectins, which are ω-3 fatty acid-derived proresolution mediators, may improve insulin resistance. Recently, protectin DX (PDX) was documented to attenuate insulin resistance by stimulating IL-6 expression in skeletal muscle, thereby regulating hepatic gluconeogenesis. These findings made us investigate the direct effects of PDX on hepatic glucose metabolism in the context of diabetes. In the current study, we show that PDX regulates hepatic gluconeogenesis in a manner distinct from its indirect glucoregulatory activity via IL-6. We found that PDX stimulated AMP-activated protein kinase (AMPK) phosphorylation, thereby inducing heme oxygenase 1 (HO-1) expression. This induction blocked hepatic gluconeogenesis by suppressing endoplasmic reticulum (ER) stress in hepatocytes under hyperlipidemic conditions. These effects were significantly dampened by silencing AMPK or HO-1 expression with small interfering RNA (siRNA). We also demonstrated that administration of PDX to high fat diet (HFD)-fed mice resulted in increased hepatic AMPK phosphorylation and HO-1 expression, whereas hepatic ER stress was substantially attenuated. Furthermore, PDX treatment suppressed the expression of gluconeogenic genes, thereby decreasing blood glucose levels in HFD-fed mice. In conclusion, our findings suggest that PDX inhibits hepatic gluconeogenesis via AMPK-HO-1-dependent suppression of ER stress. Thus, PDX may be an effective therapeutic target for the treatment of insulin resistance and type 2 diabetes through the regulation of hepatic gluconeogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Pulsed laser deposited KY3F10: Ho3+ thin films: Influence of target to substrate

    CSIR Research Space (South Africa)

    Debelo, NG

    2017-04-01

    Full Text Available The influence of target to substrate distance (dts) on the structural, morphological and photoluminescence (PL) properties of commercially obtained KY3F10 : Ho3+ phosphor thin films prepared by pulsed laser deposition is investigated for dts values...

  4. Complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III)

    International Nuclear Information System (INIS)

    Ferenc, W.; Bernat, M; Gluchowska, H.W.; Sarzynski, J.

    2010-01-01

    The complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) have been synthesized as polycrystalline hydrated solids, and characterized by elemental analysis, spectroscopy, magnetic studies and also by X-ray diffraction and thermogravimetric measurements. The analysed complexes have the following colours: violet for Nd(III), white for Gd(III) and cream for Ho(III) compounds. The carboxylate groups bind as bidentate chelating (Ho) or bridging ligands (Nd, Gd). On heating to 1173K in air the complexes decompose in several steps. At first, they dehydrate in one step to form anhydrous salts, that next decompose to the oxides of respective metals. The gaseous products of their thermal decomposition in nitrogen were also determined and the magnetic susceptibilities were measured over the temperature range of 76-303K and the magnetic moments were calculated. The results show that 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) are high-spin complexes with weak ligand fields. The solubility value in water at 293K for analysed 4-chlorophenoxyacetates is in the order of 10 -4 mol/dm 3 . (author)

  5. Magnetism and superconductivity in Eu(Ho)Mo/sub 6/S/sub 8/

    Energy Technology Data Exchange (ETDEWEB)

    Capone, D.W. II; Lai Fook, M.S.; Guertin, R.P.; Hinks, D.G.; Dunlap, B.D.; Foner, S.; Abou-Aly, A.I.; Brooks, J.S.

    1984-10-01

    A variety of ambient and high pressure experimental results reveal the interplay between magnetism and superconductivity in Ho doped samples of the pressure induced superconductor, EuMo/sub 6/S/sub 8/. Ho concentrations up to 50 atomic percent of the rare earth ions were used. High resolution magnetic measurements are consistent with the crystalline electric field ground state for the Ho/sup 3 +/ ions being a magnetic doublet consisting largely of J/sub z/ = 18. The results of high pressure magnetization experiments reveal negligible effects of reduced lattice constant on the rare earth-rare earth interactions. Resistivity in a 10 atomic percent sample for P = 10 kbar shows the suppression of a P = 0 structural transition, metallic conductivity down to low temperatures, and finally superconductivity at 8 K. The upper critical field, H/sub c2/(T), for this sample was measured for P = 7, 10 and 12 kbar and showed strong reentrant behavior (dH/sub c2/(T)/dT > 0 as T ..-->.. 0 K). A minimum with field in the resistivity above H/sub c2/ was also observed at lowest temperatures. The H/sub c2/(T) data are compared with those of EuMo/sub 6/S/sub 8/ at high pressure, which shows positive curvature, and HoMo/sub 6/S/sub 8/, in which superconductivity is quenched by ferromagnetism at low temperatures. 14 references, 4 figures.

  6. Magnetism and superconductivity in Eu(Ho)Mo6S8

    International Nuclear Information System (INIS)

    Capone, D.W. II; Lai Fook, M.S.; Guertin, R.P.; Hinks, D.G.; Dunlap, B.D.; Foner, S.; Abou-Aly, A.I.; Brooks, J.S.

    1984-10-01

    A variety of ambient and high pressure experimental results reveal the interplay between magnetism and superconductivity in Ho doped samples of the pressure induced superconductor, EuMo 6 S 8 . Ho concentrations up to 50 atomic percent of the rare earth ions were used. High resolution magnetic measurements are consistent with the crystalline electric field ground state for the Ho 3+ ions being a magnetic doublet consisting largely of J/sub z/ = 18. The results of high pressure magnetization experiments reveal negligible effects of reduced lattice constant on the rare earth-rare earth interactions. Resistivity in a 10 atomic percent sample for P = 10 kbar shows the suppression of a P = 0 structural transition, metallic conductivity down to low temperatures, and finally superconductivity at 8 K. The upper critical field, H/sub c2/(T), for this sample was measured for P = 7, 10 and 12 kbar and showed strong reentrant behavior (dH/sub c2/(T)/dT > 0 as T → 0 K). A minimum with field in the resistivity above H/sub c2/ was also observed at lowest temperatures. The H/sub c2/(T) data are compared with those of EuMo 6 S 8 at high pressure, which shows positive curvature, and HoMo 6 S 8 , in which superconductivity is quenched by ferromagnetism at low temperatures. 14 references, 4 figures

  7. Experimental study of the interaction of HO2 radicals with soot surface.

    Science.gov (United States)

    Bedjanian, Yuri; Lelièvre, Stéphane; Le Bras, Georges

    2005-01-21

    The reaction of HO2 with toluene and kerosene flame soot was studied over the temperature range 240-350 K and at P = 0.5-5 Torr of helium using a discharge flow reactor coupled to a modulated molecular beam mass spectrometer. A flat-flame burner was used for the preparation and deposition of soot samples from premixed flames of liquid fuels under well controlled and adjustable combustion conditions. The independent of temperature in the range 240-350 K value of gamma = (7.5 +/- 1.5) x 10(-2) (calculated with geometric surface area) was found for the uptake coefficient of HO2 on kerosene and toluene soot. No significant deactivation of soot surface during its reaction with HO2 was observed. Experiments on soot ageing under ambient conditions showed that the reactivity of aged soot is similar to that of freshly prepared soot samples. The results show that the HO2 + soot reaction could be a significant loss process for HOx in the urban atmosphere with a potential impact on photochemical ozone formation. In contrast this process will be negligible in the upper troposphere even in flight corridors.

  8. Neutron diffraction from HoNi2B2C

    DEFF Research Database (Denmark)

    Tomy, C.V.; Chang, L.J.; Paul, D.M.

    1995-01-01

    RENi(2)B(2)C (RE = rare-earth) are quaternary compounds which exhibit a considerable degree of interaction between their superconducting and magnetic properties. The Ho variant is found to become superconducting at T-c = 9 K, but anomalous behaviour is observed in the low-field magnetic properties...... at T demonstrate that at low temperatures (T

  9. Mechanisms of HO-1 mediated attenuation of renal immune injury: a gene profiling study.

    Science.gov (United States)

    Duann, Pu; Lianos, Elias A

    2011-10-01

    Using a mouse model of immune injury directed against the renal glomerular vasculature and resembling human forms of glomerulonephritis (GN), we assessed the effect of targeted expression of the cytoprotective enzyme heme oxygenase (HO)-1. A human (h) HO-1 complementary DNAN (cDNA) sequence was targeted to glomerular epithelial cells (GECs) using a GEC-specific murine nephrin promoter. Injury by administration of antibody against the glomerular basement membrane (anti-GBM) to transgenic (TG) mice with GEC-targeted hHO-1 was attenuated compared with wild-type (WT) controls. To explore changes in the expression of genes that could mediate this salutary effect, we performed gene expression profiling using a microarray analysis of RNA isolated from the renal cortex of WT or TG mice with or without anti-GBM antibody-induced injury. Significant increases in expression were detected in 9 major histocompatibility complex (MHC)-class II genes, 2 interferon-γ (IFN-γ)-inducible guanosine triphosphate (GTP)ases, and 3 genes of the ubiquitin-proteasome system. The increase in MHC-class II and proteasome gene expression in TG mice with injury was validated by real-time polymerase chain reaction (PCR) or Western blot analysis. The observations point to novel mechanisms underlying the cytoprotective effect of HO-1 in renal immune injury. Copyright © 2011. Published by Mosby, Inc.

  10. HO2 measurements at atmospheric concentrations using a chemical ionization mass spectrometry

    Science.gov (United States)

    Albrecht, S.; Novelli, A.; Hofzumahaus, A.; Kang, S.; Baker, Y.; Mentel, T. F.; Fuchs, H.

    2017-12-01

    Correct and precise measurements of atmospheric radical species are necessary for a better understanding of the oxidative capacity of the atmosphere. Due to the reactivity of radicals, and their consequent low concentrations, direct measurements of these species are particularly challenging and have been proven in the past to be affected by interfering species. Here we present a chemical ionization source coupled to an APi-HR-TOF-MS (Aerodyne Research Inc.), which has a limit of detection for HO2 radicals well below its atmospheric concentrations ( 1 x 108 molecules cm-3). The instrument was calibrated with a well-established and characterized HO2 calibration source in use for the laser induced fluorescence instrument in the Forschungszentrum Jülich. Within the source, a well characterized amount of HO2 radicals is produced after photolysis of water by a mercury lamp. In addition, several experiments were performed in the atmosphere simulation chamber SAPHIR at the Forschungszentrum Jülich to test for potential interferences. Measurements of HO2 radicals were concurrently detected by a laser induced fluorescence instrument allowing for the comparison of measurements within the two different and independent techniques for various atmospheric conditions regarding concentrations of O3, NOx and VOCs. Results from the intercomparison together with the calibration procedure of the instrument and laboratory characterization will be presented.

  11. The fluorite-pyrochlore transformation of Ho2-yNdyZr2O7

    International Nuclear Information System (INIS)

    Clements, Richard; Hester, James R.; Kennedy, Brendan J.; Ling, Chris D.; Stampfl, Anton P.J.

    2011-01-01

    Twelve members of the Ho 2-y Nd y Zr 2 O 7 series, prepared using conventional solid state methods, have been characterised by neutron powder diffraction. Ho 2 Zr 2 O 7 has a defect fluorite structure whereas Nd 2 Zr 2 O 7 is found to adopt the ordered pyrochlore structure with the composition induced fluorite-pyrochlore transformation occurring near y=1. Rietveld analysis on the neutron data for all the compositions reveals an increase in lattice parameter as a function of y across the entire series, with a small discontinuity associated with the transformation. The neutron profile results suggest that domains of pyrochlore-type initially begin to form before crystallising into a separate phase, and therefore that anion and cation ordering processes are distinct. There is a strong correlation between the extent of disorder in the anion sublattice and the x-parameter of 48f oxygen. These results point the way to a better understanding of the stability observed in pyrochlore structures. - Graphical abstract: Neutron diffraction profiles for Nd 2-y Ho y Zr 2 O 7 type oxides reveal details of the transformation from the ordered pyrochlore structure (y=0) to the disordered fluorite structure (y=2). Highlights: → Structures of twelve members of the Ho 2-y Nd y Zr 2 O 7 series studied using neutron powder diffraction. → Domains of pyrochlore-type materials form at low doping levels. → Higher doping stabilises the pyrochlore. → Anion and cation ordering processes are distinct.

  12. Optimalizace odpadového hospodářství farmaceutické firmy

    OpenAIRE

    Krystýnová, Hana

    2012-01-01

    Diplomová práce s názvem Optimalizace odpadového hospodářství farmaceutické firmy se nejprve zabývá základními pojmy, legislativními požadavky pro původce odpadu z hlediska vznikajících odpadů. Následuje analýza hospodaření s odpady ve zvoleném farmaceutickém podniku na výrobu generických léčiv. Dalším cílem práce je navrhnout možnosti optimalizace stávajícího systému odpadového hospodářství s ohledem na ochranu životního prostředí. The diploma thesis with the title Optimization of waste m...

  13. Psychomteric Validation of the Health of Nation Outcome Scales (HoNOS) in Traumatized Refugees

    DEFF Research Database (Denmark)

    Palic, Sabina; Elklit, Ask; Makransky, Guido

    -treatment data from 448 consecutive patients at three Danish psychiatric clinics for refugees. A10-item HoNOS version (physical problems and daily function items excluded) of pre-treatment data fit the Rasch model well. A cross validation showed excellent fit of the post-treatment data to the 10-item model...

  14. Levels in 159Ho as populated from decay of 159Er

    International Nuclear Information System (INIS)

    Boutet, J.

    1977-06-01

    The level scheme of the odd proton nucleus 159 Ho has been investigated using Ge(Li) and Si(Li) detectors. Results of γ-ray singles, conversion electron spectra and coincidence experiments are reported. Assignments are made for several energy levels

  15. HoBi-like viruses – the typical 'atypical bovine pestivirus'

    Science.gov (United States)

    HoBi-like viruses, also referred to as bovine viral diarrhea virus 3 (BVDV-3) and atypical pestivirus, have been proposed as a new putative bovine pestivirus species. These viruses were first identified in the last decade and are currently distributed in at least three continents. Published findings...

  16. Concentrations of OH and HO2 radicals during NAMBLEX: measurements and steady state analysis

    Directory of Open Access Journals (Sweden)

    S. C. Smith

    2006-01-01

    Full Text Available OH and HO2 concentrations were measured simultaneously at the Mace Head Atmospheric Research Station in the summer of 2002 during the NAMBLEX (North Atlantic Marine Boundary Layer EXperiment field campaign. OH was measured by laser-induced fluorescence employing the FAGE (Fluorescence Assay by Gas Expansion technique, with a mean daytime detection limit of 2.7×105 molecule cm−3 (5 min acquisition period; signal-to-noise ratio = 1. HO2 was detected as OH following its chemical conversion through addition of NO, with a mean detection limit of 4.4×106 molecule cm−3. The diurnal variation of OH was measured on 24 days, and that of HO2 on 17 days. The local solar noon OH concentrations ranged between (3–8×106 molecule cm−3, with a 24 h mean concentration of 9.1×105 molecule cm−3. The local solar noon HO2 concentrations were (0.9–2.1×108 molecule cm−3 (3.5–8.2 pptv, with a 24 h mean concentration of 4.2×107 molecule cm−3 (1.6 pptv. HO2 radicals in the range (2–3×107 molecule cm−3 were observed at night. During NAMBLEX, a comprehensive suite of supporting measurements enabled a detailed study of the behaviour of HOx radicals under primarily clean marine conditions. Steady state expressions are used to calculate OH and HO2 concentrations and to evaluate the effect of different free-radical sources and sinks. The diurnally averaged calculated to measured OH ratio was 1.04±0.36, but the ratio displays a distinct diurnal variation, being less than 1 during the early morning and late afternoon/evening, and greater than 1 in the middle of the day. For HO2 there was an overprediction, with the agreement between calculated and measured concentrations improved by including reaction with measured IO and BrO radicals and uptake to aerosols. Increasing the concentration of IO radicals included in the calculations to above that measured by a DOAS instrument with an absorption path located mainly over the ocean, reflecting the

  17. Our first clinical experience with radiosynoviorthesis by means of (166)Ho-holmium-boro-macroaggregates.

    Science.gov (United States)

    Kraft, Otakar; Kasparek, R; Ullmann, V; Melichar, F; Kropacek, M; Mirzajevov, M

    2005-01-01

    In this paper, we evaluate the therapeutic and adverse effects of the application of 166-holmium-boro-macroaggregates (HMBA) in radiosynovectomy (RSO) of the knees. We assessed the efficacy and safety of (166)Ho-HBMA in a prospective clinical trial in patients suffering from chronic synovitis. An effective component of radiopharmaceutical (166)Ho-boro-macroaggregates is radionuclide (166)Ho which has both beta-emission and gamma-emission. The physical half-life time of 166 Ho is 26.8 hours. After application of the radiopharmaceutical into a joint cavity, the effect of beta-emission causes radiation necrosis of pathologically changed (inflamed) synovial membrane. From 15th April 2005, we have started RSO of knees by means of new radiopharmaceutical (166)Ho-boro-macroaggregates in patients with gonarthrosis, rheumatoid arthritis, chronic synovitis, psoriatic arthritis, gout arthropathy. Seventeen intra-articular injections were performed in fifteen patients receiving a mean activity of 972 MBq (range: 904-1,057 MBq) (166)Ho-HMBA. The patients were hospitalized for three days. Side effects were evaluated during hospital stay and after 6-8 weeks. Static scintigraphy of knee joints and measurements of blood radioactivity were performed. Therapeutic effects were evaluated after 6-8 weeks. In 2 hours and 2 days after application, we proved, by means of knee and inguinal scintigraphy, only insignificant radiopharmaceutical leakage from the joint cavity to the inguinal lymph nodes in four patients. In treated patients, no serious adverse effects occurred. Nine patients were without complaints; 4 patients had slight knee exsudation and 2 patients had great exsudation. Therapeutic effects after 6-8 weeks were as follows: 2 patients were without pain, 9 with lower pain, 3 with the same pain and 1 patient with increased pain. Joint motion was improved in 7 patients, remained the same in 7 patients and was impaired in 1 patient. Analgesics consumption was lower in 5 patients

  18. Neutron activation of microspheres containing 165Ho: theoretical and experimental radionuclidic impurities study

    International Nuclear Information System (INIS)

    Squair, Peterson L.; Pozzo, Lorena; Ivanov, Evandro; Osso Junior, Joao A.

    2011-01-01

    The 166 Ho microspheres are potentially interesting for medical applications for treatment of many tumors. The internal radionuclide therapy can use polymer or glass device that provides structural support for the radionuclide. After activation, beta minus emission of 166 Ho (T 1/2 =26.8h, β - E max =1.84 MeV, γ E p =80.6 keV) can be used for therapeutic purposes. The aim of this work is study the influence of radionuclide impurities between End of Bombardment (EOB) and the medical application. The appropriate specific activities and purity along decay should be adequate for their safe and efficient medical applications. The good practices on neutron activation techniques are choice a high purity target to avoid production of undesirable radionuclides and when possible with enriched targets to obtain higher specific activity. In this work the target used was Ho 2 O 3 and polymeric microspheres containing holmium acetylacetonate (HoAcAc) manufactured at the Biotechnology Center-IPEN/CNEN-SP. Three conditions were evaluated: preliminary test with 1.0x10 13 n.cm -2 s -1 for 1.0 hour; nowadays maximum capability of IEA-R1 reactor with 5.0x10 13 n.cm -2 s -1 for 64.0 hours and the ideal IEA-R1 operation with 5.0x10 13 n.cm -2 s -1 for 120.0 hours. Considering the sample with 99.9% 165 Ho purity and 0.1% for each impurities elements with its natural abundance, the highest radionuclidic impurity is the Lutetium followed by Ytterbium, Lanthanum and Cerium. The intrinsic radionuclidic impurity of 166 mHo is less relevant. This review is important to identify the radionuclidic purity characteristics of the preliminary studies with different time and flux irradiation. The data produced in this paper will help to define strategies for the production of 166 Ho radioisotope at IEA-R1 IPEN/CNEN-SP reactor. (author)

  19. Proposed strategies for designing sustainable high-rise apartment buildings in Ho Chi Minh City responding to critical urban issues

    Science.gov (United States)

    Truong, Nguyen Hoang Long; Huan Giang, Ngoc; Binh Duong, Trong

    2018-03-01

    This paper aims at finding practical strategies for designing sustainable high-rise apartment buildings in Ho Chi Minh City responding to varied municipal issues. Two steps are made. Step-1 identifies the critical issues of Ho Chi Minh City which are associated with high-rise apartment building projects. Step-2 finds potential and applicable strategies which are solutions for the critical issues in Step-1 with reference of seven selected assessment methods. The study finds the set of 58 strategies applicable to designing sustainable high-rise apartment buildings in Ho Chi Minh City.

  20. Fundamental solution of bond pricing in the Ho-Lee stochastic interest rate model under the invariant criteria

    Directory of Open Access Journals (Sweden)

    Burhaneddin İzgi

    2017-03-01

    under the invariant criteria. We obtain transformations between Ho-Lee model with the corresponding linear (1 + 1 partial differential equation and the first Lie canonical form which is identical to the classical heat equation. These transformations help us to generate the fundamental solution for the Ho-Lee model with respect to the fundamental solution of the classical heat equation sense. Moreover, as a financial application of the Ho-Lee model, we choose the drift term from power functions and perform simulations via Milstein method. Furthermore, we obtain important results for the parameter calibration of the corresponding drift term by using the simulation results.

  1. Microstructural and dielectrical characterization of Ho doped BaTiO3 ceramics

    Directory of Open Access Journals (Sweden)

    Marjanović Miloš

    2014-01-01

    Full Text Available The Ho doped BaTiO3 ceramics, with different Ho2O3 content, ranging from 0.01 to 1.0 wt % Ho, were investigated regarding their microstructural and dielectric characteristics. Doped BaTiO3 were prepared using conventional solid state reaction and sintered at 1380°C for four hours. SEM analysis of Ho/BaTiO3 doped ceramics showed that the low doped samples exhibit mainly fairly uniform and homogeneous microstructure with the grain size ranged from 20-40 μm. In the samples with the higher dopant concentration the abnormal grain growth is inhibited and the grain size ranged between 2-10 μm. Measurements of dielectric properties were carried out as a function of temperature up to 180 °C at different frequencies. The samples doped with 0.01wt % of Ho, exhibit the high value of dielectric permittivity (εr = 2160 at room temperature. A nearly flat permittivity-response was obtained in specimens with higher additive content. Using a Curie-Weiss law and modified Curie-Weiss law the Curie constant (C, Curie temperature (Tc and a critical exponent of nonlinearity (g were calculated. The Curie temperature of doped samples were ranged from 128 to 130°C. The Curie constant for all series of samples decrease with increase of dopant concentration and the lowest values were observed on samples doped with 0.01 wt % of holmium. [Projekat Ministarstva nauke Republike Srbije, br. OI 172057: Directed synthesis, structure and properties of multifunctional materials i br. TR 32026

  2. Seasonal observations of OH and HO2 in the remote tropical marine boundary layer

    Directory of Open Access Journals (Sweden)

    Z. L. Fleming

    2012-02-01

    Full Text Available Field measurements of the hydroxyl radical, OH, are crucial for our understanding of tropospheric chemistry. However, observations of this key atmospheric species in the tropical marine boundary layer, where the warm, humid conditions and high solar irradiance lend themselves favourably to production, are sparse. The Seasonal Oxidant Study at the Cape Verde Atmospheric Observatory in 2009 allowed, for the first time, seasonal measurements of both OH and HO2 in a clean (i.e. low NOx, tropical marine environment. It was found that concentrations of OH and HO2 were typically higher in the summer months (June, September, with maximum daytime concentrations of ~9 × 106 and 4 × 108 molecule cm−3, respectively – almost double the values in winter (late February, early March. HO2 was observed to persist at ~107 molecule cm−3 through the night, but there was no strong evidence of nighttime OH, consistent with previous measurements at the site in 2007. HO2 was shown to have excellent correlations (R2 ~ 0.90 with both the photolysis rate of ozone, J(O1D, and the primary production rate of OH, P(OH, from the reaction of O(1D with water vapour. The analogous relations of OH were not so strong (R2 ~ 0.6, but the coefficients of the linear correlation with J(O1D in this study were close to those yielded from previous works in this region, suggesting that the chemical regimes have similar impacts on the concentration of OH. Analysis of the variance of OH and HO2 across the Seasonal Oxidant Study suggested that ~70% of the total variance could be explained by diurnal behaviour, with ~30% of the total variance being due to changes in air mass.

  3. Synthesis and characterization of composites HoMn_1_-_x(Ni,Co)_xO_3

    International Nuclear Information System (INIS)

    Santos, Cassio Morilla dos

    2011-01-01

    In this work was accomplished the synthesis process and structural and magnetic characterization of HoMn_1_-_X(Ni,Co)_XO_3 compounds of perovskite structure. The samples synthesis were performed through modified polymeric precursor method. After synthesis and solvent removal, the polymer resin formed was treated at 350 deg C/4h for organic constituents removal, followed by heating treatment at 500 deg C/4h and 900 deg C/20h to obtain the crystalline phase. For structural characterization, it was used D10B-XPD beam line of Laboratorio Nacional de Luz Sincrotron (LNLS), where X-rays wavelengths below cobalt, manganese and nickel absorption edge, were used. The formation of HoNi_0_._5_0Mn_0_._5_0O_3, HoCo_0_._5_0Mn_0_._5_0O_3 and HoNi_0_._2_5Co_0_._2_5Mn_0_._5_0O_3 phases were observed by X-ray diffraction technique. By Rietveld refinement method for sample HoNi_0_._2_5Co_0_._2_5Mn_0_._5_0O_3, it was determined that cobalt and nickel had similar occupations at the top and bottom of unit cell, while the manganese preferentially occupied plan 002. The magnetic response of samples was studied through magnetization curves according to the temperature function and the applied magnetic field. The ZFC curves showed a paramagnetic response associated to holmium magnetic moment, and ferromagnetism, antiferromagnetism and ferrimagnetism coexistence, due to sublattices formed by transition metals. The FC curves evidenced the spin reversal phenomenon, associated to the interaction between the sublattice formed by transition metals with sublattices formed by rare-earth, considering a mechanism of antiferromagnetic exchange interaction. (author)

  4. Does acetone react with HO2 in the upper-troposphere?

    Directory of Open Access Journals (Sweden)

    J. Lelieveld

    2012-02-01

    Full Text Available Recent theoretical calculations showed that reaction with HO2 could be an important sink for acetone (CH3C(OCH3 and source of acetic acid (CH3C(OOH in cold parts of the atmosphere (e.g. the tropopause region. This work details studies of HO2 + CH3C(OCH3 (CH32C(OHOO (R1 in laboratory-based and theoretical chemistry experiments; the atmospheric significance of Reaction (R1 was assessed in a global 3-D chemical model. Pulsed laser-kinetic experiments were conducted, for the first time, at the low-temperatures representative of the tropopause. Reaction with NO converted HO2 to OH for detection by laser induced fluorescence. Reduced yields of OH at T 2 by CH3C(OCH3 with a forward rate coefficient greater than 2 × 10−12 cm3 molecule−1 s−1. No evidence for Reaction (R1 was observed at T > 230 K, probably due to rapid thermal dissociation back to HO2 + CH3C(OCH3. Numerical simulations of the data indicate that these experiments were sensitive to only (R1a HO2-CH3C(OCH3 complex formation, the first step in (R1. Rearrangement (R1b of the complex to form peroxy radicals, and hence the atmospheric significance of (R1 has yet to be rigorously verified by experiment. Results from new quantum chemical calculations indicate that K1 is characterised by large uncertainties of at least an order of magnitude at T 3C(OCH3 near the tropopause, it cannot explain observations of CH3C(OOH throughout the troposphere.

  5. Spectroscopic properties of Ho{sup 3+}-doped K-Sr-Al phosphate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Linganna, K.; Rathaiah, M.; Venkatramu, V. [Yogi Vemana University, Department of Physics, Kadapa (India); Jayasankar, C.K. [Sri Venkateswara University, Department of Physics, Tirupati (India)

    2014-05-15

    Trivalent holmium-doped K-Sr-Al phosphate glasses (P{sub 2}O{sub 5}-K{sub 2}O-SrO-Al{sub 2}O{sub 3}-Ho{sub 2}O{sub 3}) were prepared, and their spectroscopic properties have been evaluated using absorption, emission, and excitation measurements. The Judd-Ofelt theory has been used to derive spectral intensities of various absorption bands from measured absorption spectrum of 1.0 mol% Ho{sub 2}O{sub 3}-doped K-Sr-Al phosphate glass. The Judd-Ofelt intensity parameters (Ω{sub λ}, x 10{sup -20} cm{sup 2}) have been determined of the order of Ω{sub 2} = 11.39, Ω{sub 4} = 3.59, and Ω{sub 6} = 2.92, which in turn used to derive radiative properties such as radiative transition probability, radiative lifetime, branching ratios, etc. for excited states of Ho{sup 3+} ions. The radiative lifetimes for the {sup 5}F{sub 4}, {sup 5}S{sub 2}, and {sup 5}F{sub 5} levels of Ho{sup 3+} ions are found to be 169, 296, and 317 μs, respectively. The stimulated emission cross-section for 2.05-μm emission was calculated by the McCumber theory and found to be 9.3 x 10{sup -21} cm{sup 2}. The wavelength-dependent gain coefficient with population inversion rate has been evaluated. The results obtained in the titled glasses are discussed systematically and compared with other Ho{sup 3+}-doped systems to assess the possibility for visible and infrared device applications. (orig.)

  6. Ho:YAG laser: intervertebral disk cell interaction using three-dimensional cell culture system

    Science.gov (United States)

    Sato, Masato; Ishihara, Miya; Arai, Tsunenori; Asazuma, Takashi; Kikuchi, Toshiyuki; Kikuchi, Makoto; Fujikawa, Kyosuke

    2000-06-01

    The purpose of this study is to evaluate the influence on the intervertebral disc cells after laser irradiation using three- dimensional culture system and to clarify the optimum Ho:YAG laser irradiation condition on percutaneous laser disc decompression (PLDD) for lumbar disc herniation. Since the Ho:YAG laser ablation is characterized by water-vapor bubble dynamics, not only thermal effect but also acoustic effect on cell metabolism might occur in the intervertebral disc. We studied the disc cell reaction from the metabolic point of view to investigate photothermal and photoacoustic effects on three-dimensional cultured disc cell. Intervertebral discs were obtained from female 30 Japanese white rabbits weighing about 1 kg. A pulsed Ho:YAG laser (wavelength: 2.1 micrometer, pulse width: about 200 microseconds) was delivered through a 200 micrometer-core diameter single silica glass fiber. We used the Ho:YAG laser irradiation fluence ranging from 60 to approximately 800 J/cm2 at the fiber end. To investigate acoustic effect, the acoustic transducer constructed with polyvinylidene fluoride (PVdF) film and acoustic absorber was used to detect the stress wave. Thermocouple and thermography were used to investigate thermal effect. Concerning damage of plasma membrane and ability of matrix synthesis, thermal effect might mainly affect cell reaction in total energy of 54 J (closed to practically used condition), but in 27 J, acoustic effect might contribute to it. We found that total energy was key parameter among the optimum condition, so that temperature and/or stress wave may influence Ho:YAG laser-disc cell interactions.

  7. Clinical study of liver cancer (Hepatocellular carcinoma) by 166 Ho-CHICO

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. T.; Yoo, H. S.; Lee, J. D.; Lee, D. Y.; Kim, E. K.; Yoo, N. C.; Shin, S. J.; Han, K. H. [Yonsei University, Seoul (Korea); Park, K. B. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-04-01

    As having used Ho-166 Chitosan complex, this study was designed for the development of new therapeutic agent in the treatment of liver cancer (hepatocellular carcinoma). During the period of 3 years from April 1, 1997 to March 31, 2000, this project was successfully performed on the base of clinical experience with percutaneous Ho-166 CHICO injection in the treatment of liver cancer'. In order to evaluate the biodistribution and effect of Ho-166 CHICO was performed in 50 patients, who had the progressed liver cancer with range of 3-10cm in diameter. After the administration of the complex materials, we evaluated the therapeutic effect as well as complication by the follow-up study that included laboratory examination, radioactivity counting and various imaging modalities. 1) In animal experiment, radioactivity of target liver was ranged between 27-33% of total body one, urine excretion between 0.17-0.24 %. White blood cell and platelet counts start diminishing within 7 days and at maximum within 4 weeks after administration of complex materials. In tissue changes of target liver was revealed no significant change in the tumor dose of Ho-166, but periportal fibrosis and massive tissue necrosis in the high ones. 2) In clinical study, total necrosis of tumor is 66%, partial 10% and non-response 24% among 50 patients' liver cancer. The most important complication were leukopenia and thrombocytopenia (82%), the remained was abdominal pain(34%), skin reaction(12%), bile duct obstruction(10%), liver abscess(6%) etc. Conclusively intraarterial injection of Ho-166 CHICO was effective in the treatment of larger and progressed liver cancer. 19 refs., 14 figs., 8 tabs. (Author)

  8. Investigation of complexes with bone affinity using the In vivo generator system 166 Dy/166 Ho

    International Nuclear Information System (INIS)

    Pedraza L, M.

    2006-01-01

    The importance of this original research lies in the fact that it has proven that the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system is a stable complex that can be used as a therapeutic radiopharmaceutical. Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. Bone-seeking radiopharmaceuticals such as 166 Ho-DOTMP or 153 Sm-DTMP, have been proposed for delivering ablative radiation doses to marrow in multiple myeloma and other hematological malignancies or have shown excellent results in palliative bone metastasis pain therapy, respectively. As lanthanides have similar chemical characteristics the phosphonate with bone affinity (EDTMP) labeled with Dy/Ho can be used for marrow ablation while causing minimal irradiation to normal organs. This in vivo generator system has not been previously reported. The aim of this research was to label EDTMP (ethylene diamine tetramethylene phosphonate) with 166 Dy/ 166 Ho; to evaluate the in vitro and in vivo stability of both 166 Dy-EDTMP and 166 Ho-EDTMP complexes when the daughter 166 Ho is formed as a dysprosium decay product; to determine the bone marrow cytotoxic and genotoxic effect in mice and to evaluate, by histopathology, the myeloablative potential of the [ 166 Dy]Dy/ 166 Ho-EDTMP in vivo generator system. 166 Dy was obtained by neutron irradiation of enriched 164 Dy 2 O 3 in a TRIGA Mark III reactor. Labeling was carried out in an aqueous phosphate medium at pH 8.0 by addition of 166 DyCl 3 to EDTMP at a molar ratio 1:1.75, with >99 % radiochemical purity, as determined by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In vitro studies demonstrated that 166 Dy/ 166 Ho-EDTMP is unstable after dilution in saline but stable in human serum with no translocation of the daughter nucleus subsequent to β decay of 166 Dy, which could release free 166 Ho 3+ . Biodistribution in mice

  9. Srovnání některých dat registru alert-cz s daty dřívějšího pilotního registru akutního infarktu myokardu

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Reissigová, Jindra; Tomečková, Marie; Grünfeldová, H.; Janský, P.; Monhart, Z.; Vojáček, J.; Widimský, J.; Zvárová, Jana

    2010-01-01

    Roč. 52, Suppl. 1 - CD ROM (2010), A248 ISSN 0010-8650. [Výroční sjezd České kardiologické společnosti /18./. 16.05.2010-19.05.2010, Brno] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : registr akutního infarktu myokardu * rizikové faktory infarktu myokardu * PCI a akutní farmakoterapie infarktu myokardu Subject RIV: IN - Informatics, Computer Science

  10. Highly efficient red upconversion fluorescence emission in Yb{sup 3+}/Ho{sup 3+}/Ce{sup 3+} codoped LaF{sub 3} nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Wei, E-mail: gaowei@xupt.edu.cn; Dong, Jun; Liu, Jihong; Yan, Xuewen

    2016-11-15

    The Yb{sup 3+}/Ho{sup 3+}/Ce{sup 3+} codoped LaF{sub 3} nanocrystals have been successfully prepared via a facile hydrothermal method. The significant enhancement in the red upconversion emission of Ho{sup 3+} is successfully obtained in LaF{sub 3}:Yb{sup 3+}/Ho{sup 3+} nanocrystals through introducing of Ce{sup 3+} under NIR excitation at 980 nm. The red-to-green emission ratio of Ho{sup 3+} is enhanced 18.9-fold with Ce{sup 3+} concentration increasing to 12%, which is due to the two efficient cross relaxation processes of {sup 5}I{sub 6} (Ho{sup 3+})+{sup 2}F{sub 5/2} (Ce{sup 3+})→{sup 5}I{sub 7} (Ho{sup 3+})+{sup 2}F{sub 7/2} (Ce{sup 3+}) and {sup 5}S{sub 2}/{sup 5}F{sub 4} (Ho{sup 3+})+{sup 2}F{sub 5/2} (Ce{sup 3+})→{sup 5}F{sub 5} (Ho{sup 3+})+{sup 2}F{sub 7/2} (Ce{sup 3+}) between Ho{sup 3+} and Ce{sup 3+} ions. The enhancement mechanism of red emission and conversion efficiency between Ho{sup 3+} and Ce{sup 3+} are investigated in detail.

  11. {sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, M; Errazu, X [Comision Chilena de Energia Nuclear, Santiago (Chile); Mendoza, P [Departamento de Medicina Nuclear, Hospital Militar, Santiago (Chile); Troncoso, F [Comision Chilena de Energia Nuclear, Santiago (Chile); Jofre, J; Sierralta, P [Departamento de Medicina Nuclear, Hospital Militar, Santiago (Chile)

    2003-01-01

    Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate {sup 166}Ho-Hydroxyapatite ({sup 166} Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: {sup 166}Holmiun was produced by irradiation of Ho{sub 2}O{sub 3} at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the {sup 166}Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using {sup 67}Ga citrate before and after {sup 166} Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The {sup 166} Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extraarticular leakage. From the {sup 67}Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The {sup 166}Ho-HA double dosis, compared to the single dosis, suggest a reduced uptake of {sup 67}Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: {sup 166} Ho-HA is usefull as therapeutic agent for the syntomatic treatment of rheumatoideal arthritis

  12. Structure determination, electronic and optical properties of rubidium holmium polyphosphate RbHo(PO3)4

    Science.gov (United States)

    Zhu, Jing; Chen, Hui; Wang, Yude; Guan, Hongtao; Xiao, Xuechun

    2012-12-01

    Structural, optical, and electronic properties of a new alkali metal-rare earth polyphosphate, RbHo(PO3)4, have been investigated by means of single-crystal X-ray diffraction, power X-ray diffraction, elemental analysis, and spectral measurement. RbHo(PO3)4 crystallizes in the monoclinic with space group P21/n and Z = 4. It is described as a three-dimensional (3D) architecture built up of PO4 double spiral chains and HoO8 polyhedra by corner-sharing. The 11-coordinated rubidium atoms are located in infinite tunnels. Additionally, in order to gain further insight into the relationship between property and structure of RbHo(PO3)4, theoretical calculation based on the density functional theory (DFT) was performed using the total-energy code CASTEP.

  13. Structural and electronic effects of the solid-state amorphization and recrystallization of Cu--Ho thin films

    International Nuclear Information System (INIS)

    Venkert, A.; Shamir, N.; Talianker, M.; Atzmony, U.; Dariel, M.P.; Ben-Gurion University, Material Engineering, P.O. Box 653, Beer-Sheva, Israel)

    1987-01-01

    Amorphous alloys can be produced as the outcome of diffusion reaction between evaporated thin crystalline films. The Cu--Ho system is a favorable one for such a reaction to occur. The amorphization and the recrystallization of Cu--Ho multilayers has been previously observed using transmission electron microscopy. In the present study the various stages of the interdiffusion processes in this multilayer system were investigated by means of electron spectroscopy techniques. Auger electron spectroscopy depth profiling showed the evolution of the mixing process from the multilayer structure to its completion. The mixing process was accompanied by a shift without broadening of the x-ray photoelectron spectroscopy Ho 4d line. This shift is attributed to a charge transfer from the Ho ion. The lack of line broadening indicated that the mixing was completed down to the atomic level

  14. Study of Ho-doped Bi{sub 2}Te{sub 3} topological insulator thin films

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, S. E. [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States); Collins-McIntyre, L. J.; Zhang, S. L.; Chen, Y. L.; Hesjedal, T., E-mail: Thorsten.Hesjedal@physics.ox.ac.uk [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Baker, A. A. [Department of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Magnetic Spectroscopy Group, Diamond Light Source, Didcot OX11 0DE (United Kingdom); Figueroa, A. I.; Laan, G. van der [Magnetic Spectroscopy Group, Diamond Light Source, Didcot OX11 0DE (United Kingdom); Kellock, A. J.; Pushp, A.; Parkin, S. S. P. [IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120 (United States); Harris, J. S. [Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States)

    2015-11-02

    Breaking time-reversal symmetry through magnetic doping of topological insulators has been identified as a key strategy for unlocking exotic physical states. Here, we report the growth of Bi{sub 2}Te{sub 3} thin films doped with the highest magnetic moment element Ho. Diffraction studies demonstrate high quality films for up to 21% Ho incorporation. Superconducting quantum interference device magnetometry reveals paramagnetism down to 2 K with an effective magnetic moment of ∼5 μ{sub B}/Ho. Angle-resolved photoemission spectroscopy shows that the topological surface state remains intact with Ho doping, consistent with the material's paramagnetic state. The large saturation moment achieved makes these films useful for incorporation into heterostructures, whereby magnetic order can be introduced via interfacial coupling.

  15. Search of fission products in 20Ne-ion beam interaction with 165Ho at 8 MeV/nucleon

    International Nuclear Information System (INIS)

    Singh, D.; Ali, R.; Afzal Ansari, M.; Rashid, M.H.

    2006-01-01

    In the present work, during the study complete fusion (CF) and incomplete fusion (ICF) in 20 Ne-induced reactions, the production cross-sections for several fission products in 20 Ne + 165 Ho system have been measured

  16. em cristais de Ho:YLF e Er:YLF na região de 3m

    Directory of Open Access Journals (Sweden)

    Fábio Henrique Jagosich

    2006-01-01

    Full Text Available In this work, the deactivation energy transfer mechanisms of 4I13/2 of Er3+ and 5I7 of Ho3+ levels in crystals of LiYF4 (YLF co-doped with Nd3+, Tb3+ and Eu3+ are studied. It was determined the best combination with deactivator ions, capable to maximize the laser gain in the middle of the Ho3+ in 2.9 micrometers (mm and the Er3+ in 2.75 mm operation. The results showed that the Tb3+ and Eu3+ are the best deactivators to the Ho3+ laser operation, while for the Ho3+ laser operation, the best ion deactivator is the Nd3+. The energy transfer characterizations were carried out using the Förster-Dexter method, which consists in the determination of the interaction critic ray, to start from the integral superposition of the absorption cross section spectrum and the involved ions emission.

  17. Dosimetric intercomparison of permanent Ho-166 seed's implants and HDR Ir-192 brachytherapy in breast cancer.

    Science.gov (United States)

    de Campos, Tarcisio Passos Ribeiro; Nogueira, Luciana Batista; Trindade, Bruno; Cuperschmid, Ethel Mizrahy

    2016-01-01

    To provide a comparative dosimetric analysis of permanent implants of Ho(166)-seeds and temporary HDR Ir(192)-brachytherapy through computational simulation. Brachytherapy with Ir(192)-HDR or LDR based on temporary wires or permanent radioactive seed implants can be used as dose reinforcement for breast radiation therapy. Permanent breast implants have not been a practical clinical routine; although, I(125) and Pd(103)-seeds have already been reported. Biodegradable Ho(166)-ceramic-seeds have been addressed recently. Simulations of implants of nine Ho(166)-seeds and equivalent with HDR Ir(192)-brachytherapy were elaborated in MCNP5, shaped in a computational multivoxel simulator which reproduced a female thorax phantom. Spatial dose rate distributions and dose-volume histograms were generated. Protocol's analysis involving exposure time, seed's activities and dose were performed. Permanent Ho(166)-seed implants presented a maximum dose rate per unit of contained activity (MDR) of 1.1601 μGy h(-1) Bq(-1); and, a normalized MDR in standard points (8 mm, equidistant to 03-seeds - SP1, 10 mm - SP2) of 1.0% (SP1) and 0.5% (SP2), respectively. Ir(192)-brachytherapy presented MDR of 4.3945 × 10(-3) μGy h(-1) Bq(-1); and, 30% (SP1), and 20% (SP2). Therefore, seed's implant activities of 333 MBq (Ho(166)) and 259 GBq (Ir(192)) produced prescribed doses of 58 Gy (SP1; 5d) and 56 Gy (SP1, 5 fractions, 6 min), respectively. Breast Ho(166)-implants of 37-111 MBq are attractive due to the high dose rate near 6-10 mm from seeds, equivalent to Ir(192)-brachytherapy of 259 GBq (3 fractions, 6 min) providing similar dose in standard points at a week; however, with spatial dose distribution better confined. The seed positioning can be adjusted for controlling the breast tumor, in stages I and II, in flat and deep tumors, without any breast volumetric limitation.

  18. Optical properties of Mg2+, Yb3+, and Ho3+ tri-doped LiNbO3 crystals

    Science.gov (United States)

    Dai, Li; Liu, Chun-Rui; Tan, Chao; Yan, Zhe-Hua; Xu, Yu-Heng

    2017-04-01

    A series of LiNbO3 crystals tri-doped with Mg{}2+, Yb{}3+, and Ho{}3+ are grown by the conventional Czochraski technique. The concentrations of Mg{}2+, Yb{}3+, and Ho{}3+ ions in Mg:Yb:Ho:LiNbO3 crystals are measured by using an inductively coupled plasma atomic emission spectrometry. The x-ray diffraction is proposed to determine the lattice constant and analyze the internal structure of the crystal. The light-induced scattering of Mg:Yb:Ho:LiNbO3 crystal is quantitatively described via the threshold effect of incident exposure energy flux. The exposure energy ({E}{{r}}) is calculated to discuss the optical damage resistance ability. The exposure energy of Mg(7 mol):Yb:Ho:LiNbO3 crystal is 709.17 J/cm2, approximately 425 times higher than that of the Mg(1 mol):Yb:Ho:LiNbO3 crystal in magnitude. The blue, red, and very intense green bands of Mg:Yb:Ho:LiNbO3 crystal are observed under the 980-nm laser excitation to evaluate the up-conversion emission properties. The dependence of the emission intensity on pumping power indicates that the up-conversion emission is a two-photon process. The up-conversion emission mechanism is discussed in detail. This study indicates that Mg:Yb:Ho:LiNbO3 crystal can be applied to the fabrication of new multifunctional photoluminescence devices. Project supported by the National Natural Science Foundation of China (Grant No. 51301055), the Youth Science Fund of Heilongjiang Province, China (Grant No. QC2015061), the Special Funds of Harbin Innovation Talents in Science and Technology Research, China (Grant No. 2015RQQXJ045 ), and the Science Funds for the Young Innovative Talents of Harbin University of Science and Technology, China (Grant No. 201501).

  19. hHO-1 combined with GATA-4 transduction promotes myocardial transdifferentiation and anti- apoptosis of rat mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Ning-bo DENG

    2017-06-01

    Full Text Available Objectives To explore if the rat bone marrow mesenchymal stem cells (BMSCs modified by human heme oxygenase 1 (hHO-1 gene combined with GATA-4 gene may promote the ability of anti-apoptosis and myocardial transdifferentiation in vitro in hypoxia ischemic environment. Methods The rat BMSCs were isolated and cultured by whole bone marrow adherence and identified in vitro, and then were transfected with recombinant adenovirus; Western blotting was used to determinate the optimal time of gene expression; the genetically modified BMSCs were taken to hypoxia serum-free conditions simulating ischemia hypoxia microenvironment in vivo; CCK-8 kit and trypan blue staining were performed to detect the 12, 24, 48 and 72h survival rates in hypoxia ischemia respectively; flow cytometry was used to detect the apoptosis of BMSCs in hypoxia ischemia for 24h. The cardiomyocyte-specific cardiac troponin I (cTnI was detected by Western blotting and cellular immunofluorescence. Results The 12, 24, 48 and 72h survival rates were higher in hHO-1+GATA-4 group cultured in ischemia and hypoxia condition than in hHO-1 group (P<0.05 and GATA-4 group (P<0.05. After 24h cultivation in ischemia hypoxia condition, the apoptotic rates were lower in hHO-1+GATA-4 group than in hHO-1 group (P<0.05 and GATA-4 group (P<0.05. No significant difference existed in cTnI expressions between GATA-4 group and hHO-1+GATA-4 group. Conclusion Compared with transfection of hHO-1 or GATA-4 single gene, hHO-1 combined with GATA-4 transduction can significantly increase the survival rate of BMSCs in hypoxia ischemic condition, but myocardial transdifferentiation does not increase significantly. DOI: 10.11855/j.issn.0577-7402.2017.04.08

  20. Kundalini Yoga, Yogi Tee und das Wassermannzeitalter: Bibliografische Einblicke in die Healthy, Happy, Holy Organization (3HO) des Yogi Bhajan

    OpenAIRE

    Laue, Thorsten

    2008-01-01

    Obwohl seit 40 Jahren im Westen aktiv, ist die Healthy, Happy, Holy Organization (3HO) des Yogi Bhajan (1929-2004) von der deutschen wie internationalen Forschung weitestgehend übersehen worden. Um dieser Forschungslücke entgegenzuwirken, verfasste ich 2003 meine religionswissenschaftlich begründete Magisterarbeit Darstellung und Quellen der 3HO Deutschland e.V. Aus dem Darstellungsteil entstand die 2007 im Münsteraner LIT-Verlag publizierte Monographie Kundalini Yoga, Yogi Tee und das Wasser...

  1. Investigation on Er{sup 3+}/Ho{sup 3+} co-doped silicate glass for ~2 µm fiber lasers

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xueqiang; Huang, Feifei; Cheng, Jimeng; Fan, Xiaokang; Gao, Song [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Science, Beijing 100039 (China); Zhang, Junjie [College of Materials Science and Technology, China Jiliang University, Hangzhou 310018 (China); Hu, Lili [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Chen, Danping, E-mail: dpchen2008@aliyun.com [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2015-06-15

    A stable Er{sup 3+}/Ho{sup 3+} co-doped lead silicate glass is developed. Luminescent properties are recorded under pumping with 808 and 1550 nm lasers. Energy-transfer mechanism and efficiency are analyzed. Energy-transfer efficiency from Er{sup 3+}:{sup 4}I{sub 13/2} to Ho{sup 3+}:{sup 5}I{sub 7} reaches 93.8% at 3 mol% Ho{sub 2}O{sub 3} doping concentration. Strong luminescence is detected when pumped at 1550 nm because of efficient energy transfer from Er{sup 3+}:{sup 4}I{sub 13/2} to Ho{sup 3+}:{sup 5}I{sub 7}. Peak gain coefficient at 2056 nm is detected as 1.62 cm{sup −1}. The excellent luminescent property and high stability indicate that Er{sup 3+}/Ho{sup 3+} co-doped lead silicate glass can be applied in 2 µm fiber lasers. - Highlights: • Er{sup 3+}/Ho{sup 3+} co-doped silicate glasses with high stability are prepared. • Strong luminescence is detected under pump of 1550 nm lasers owing to efficient energy transfer from Er{sup 3+} to Ho{sup 3+}. • Transfer efficiency is calculated to be 93.8% when Ho{sub 2}O{sub 3} doping concentration is up to 3 mol%. • Gain coefficient peaks at 2056 nm to be 1.62 cm{sup −1}.

  2. Magnetic phase transitions and large magnetic entropy change with a wide temperature span in HoZn

    Energy Technology Data Exchange (ETDEWEB)

    Li, Lingwei, E-mail: wei0396@hotmail.com [Key Laboratory of Electromagnetic Processing of Materials (Ministry of Education), Northeastern University, Shenyang 110819 (China); Institut für Anorganische und Analytische Chemie, Universität Münster, Corrensstrasse 30, D-48149 Münster (Germany); Yuan, Ye [Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Ion Beam Physics and Materials Research, P.O. Box 510119, 01314 Dresden (Germany); Zhang, Yikun [Key Laboratory of Electromagnetic Processing of Materials (Ministry of Education), Northeastern University, Shenyang 110819 (China); Pöttgen, Rainer [Institut für Anorganische und Analytische Chemie, Universität Münster, Corrensstrasse 30, D-48149 Münster (Germany); Zhou, Shengqiang [Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Ion Beam Physics and Materials Research, P.O. Box 510119, 01314 Dresden (Germany)

    2015-09-15

    Highlights: • Magnetic phase transitions and magnetocaloric effect in HoZn were studied. • The critical properties of HoZn were systematically investigated. • The obtained critical exponents are satisfied with scaling theory. • A large reversible magnetocaloric effect in HoZn was observed. • HoZn could be a promising candidate for magnetic refrigeration. - Abstract: CsCl-type HoZn undergoes two successive magnetic phase transitions: (i) paramagnetic to ferromagnetic (FM) at T{sub C} ∼ 72 K and (ii) a spin reorientation (SR) at T{sub SR} ∼ 26 K. Magnetization and modified Arrott plots indicate that HoZn undergoes a second-order magnetic phase transition around T{sub C}. The obtained critical exponents have some small deviations from the mean-field theory, indicating a short range or a local magnetic interaction which is properly related to the coexistence of FM and SR transitions at low temperature. Two successive magnetic transitions in HoZn induce one broad pronounced peak together with a shoulder in the temperature dependence of the magnetic entropy change −ΔS{sub M}(T) curves, resulting in a wide temperature range with a large relative cooling power (RCP). For a field change of 0–7 T, the maximum value of −ΔS{sub M} is 15.2 J/kg K around T{sub C} with a large RCP value of 1124 J/kg. The large reversible magnetocaloric effect (MCE) and RC indicate that HoZn is a good candidate for active magnetic refrigeration.

  3. Observation of a reorientation of the holmium moments in HoAl2 with polarized neutron diffraction

    International Nuclear Information System (INIS)

    Barbara, B.; Boucherle, J.X.; Rossignol, M.F.; Schweizer, J.

    1976-01-01

    Magnetization measurements performed on a single crystal of HoAl 2 show that the easy axis of magnetization is [110] at low temperature and suggest near 20 0 K a rotation of the easy direction of magnetization. This rotation has been strikingly demonstrated by polarized neutron diffraction experiments including measurements of intensities with both spin states and of depolarization through the sample. This result allows the interpretation of the magnetic properties of HoAl 2 in terms of crystal field

  4. Beam delivery system for Ho:YLF and applications in endodontics; Sistema de entrega de feixe para laser de Ho:YLF e aplicacoes em endodontia

    Energy Technology Data Exchange (ETDEWEB)

    Bachmann, Luciano

    2000-07-01

    The beam delivery systems, whether using fibers or articulated arms, are very important for the expansion of laser applications into life sciences. This work aims to couple an optical fiber to a home-made Er:Tm:Ho:LiYF{sub 4} laser. For this purpose the beam profile was studied using the beam quality factor M{sup 2} to achieve an homogeneous beam. To determine the M{sup 2} factor, the knife-edge technique was used, relating the laser energy eclipsed by the knife with its transversal position. The resonant cavity was made suitable in order to obtain a stable and homogeneous transversal beam profile, for the optical fiber coupling. It was used a 365 {mu}m diameter core low OH{sup -} content fused silica optical fiber, with a proximal SMA-905 connection and a flat distal end. M{sup 2} factors for the Ho:YLF were between 3 and 8, with a non astigmatic beam, although it was observed a divergence asymmetry in the transversal sections. The coupling efficiency was 96%, and in a repeated operation without any adjustment, the new coupling were 82% and 81%. Lasers have being recently used as an adjunct to conventional endodontic preparation to reduce intracanal microbial, preventing reinfection. The knowledge of thermal profile in endodontic procedures is important to determine laser irradiation conditions avoiding periodontal damages. In this sense, the second scope of this work was to use the Ho:YLF system to register the thermal profile in vitro and to compare the results with those obtained with Nd:YAG and Er:YAG commercial lasers. The temperature was recorded in real time through a thermocouple probe at the root apex , resulting in maximum increase of 7 deg C. (author)

  5. An inter-comparison of HO2 measured by Fluorescence Assay by Gas Expansion and Cavity Ringdown Spectroscopy in the Highly Instrumented Reactor for Atmospheric Chemistry.

    Science.gov (United States)

    Brennan, A.; Onel, L. C.; Gianella, M.; Ronnie, G.; Aguila, A. L.; Hancock, G.; Whalley, L.; Seakins, P. W.; Ritchie, G.; Heard, D. E.

    2017-12-01

    HO2 is an important species in the atmosphere, as it is involved in the HOx radical reaction cycle that is critical to the oxidation of atmospheric pollutants and the ultimate cleaning of the troposphere. One of the most widely utilised methods to measure HO2 is Fluorescence Assay by Gas Expansion (FAGE), which indirectly measures HO2 by sampling into a low pressure cell and titrating HO2 with NO to produce OH that is then detected by Laser Induced Fluorescence. This is an indirect and non-absolute detection technique that requires careful calibration to convert the measured signal into [HO2], which involves the photolysis of H2O at 185 nm to produce OH and HO2, and is subject to 30 % errors at 2σ level. The work presented here shows the validation of the FAGE technique and its calibration procedure through inter-comparison experiments between the non-absolute FAGE technique and Cavity Ringdown Spectroscopy (CRDS), an absolute absorption based method. The CRDS system was used to excite the first O-H overtone of the HO2 absorption band at 1506.43 nm, and features a cavity length of 1.2 m and a total path of 60 km. The experiments were performed inside the 2.25 m3 stainless steel Highly Instrumented Reactor for Atmospheric Chemistry (HIRAC), using a synthetic air mixture at 150 and 1000 mbar of pressure and 298 K. HO2 was generated by photolysis of Cl2 at 365 nm in the presence of CH3OH and O2, and the [HO2] was monitored using both instruments. Additionally, monitoring the temporal decay of HO2 during its self-reaction provided an alternative calibration method for the FAGE instrument, and allowed the absorption cross section of HO2 at 1506.43 nm, σHO2, to be measured. FAGE calibration factors determined through the second order decays of HO2 at 1000 mbar agreed within 8 % of the H2O photolysis method, and determinations of σHO2 at 150 and 1000 mbar agree with previously reported data within 20 % and 12 % respectively. [HO2] correlation plots between the two

  6. Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Young; Kim, Joo Young; Sung, Yoon-Young; Jung, Won Hoon; Kim, Hee-Youn; Park, Ji Seon; Cheon, Hyae Gyeong [Medicinal Science Division, Korea Research Institute of Chemical Technology, 100 Jang-dong, Yuseong, 305-600 Daejon (Korea, Republic of); Rhee, Sang Dal, E-mail: sdrhee@krict.re.kr [Medicinal Science Division, Korea Research Institute of Chemical Technology, 100 Jang-dong, Yuseong, 305-600 Daejon (Korea, Republic of)

    2011-03-25

    Research highlights: {yields} In this study, we investigated the effects of leptin on adipocyte differentiation prepared from subcutaneous fat of TallyHo mice. {yields} Leptin inhibited the adipocytes differentiation at physiological concentration via inhibition of PPAR{gamma} expression. {yields} Inhibitors of ERK and STAT1 restored the leptin's inhibitory activity both in vitro and in vivo. -- Abstract: The effects of leptin on rosiglitazone-induced adipocyte differentiation were investigated in the primary adipocytes prepared from subcutaneous fat of TallyHO/Jng (TallyHO) mouse, a recently developed model animal for type 2 diabetes mellitus (T2DM). The treatment of leptin inhibited the rosiglitazone-induced adipocyte differentiation with a decreased expression of peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) a key adipogenic transcription factor, both in mRNA and protein levels. Leptin (10 nM) was sufficient to inhibit the adipocyte differentiation, which seemed to come from increased expression of leptin receptor genes in the fat of TallyHO mice. The inhibition of adipogenesis by leptin was restored by the treatment of inhibitors for extracellular-signal-regulated kinase (ERK) (PD98059) and signal transducer and activator of transcription-1 (STAT1) (fludarabine). Furthermore, in vivo intraperitoneal administration of PD98059 and fludarabine increased the PPAR{gamma} expression in the subcutaneous fat of TallyHO mice. These data suggest that leptin could inhibit the PPAR{gamma} expression and adipocyte differentiation in its physiological concentration in TallyHO mice.

  7. Návrh Rail-to-Rail operačního zesilovače v technologii CMOS

    OpenAIRE

    Cvešper, Stanislav

    2016-01-01

    Práce se zabývá návrhem rail-to-rail operačního zesilovače ve třídě AB v technologii CMOS I3T25. Práce začíná úvodem do CMOS tranzistorů, následuje rozbor struktur operačního zesilovače, jeho návrh a simulace v návrhovém prostředí Cadence, popsány jsou také různé metody pro minimalizaci napěťové symetrie. Hlavním cílem práce je dosažení rail-to-rail vstupního i výstupního rozsahu operačního zesilovače pracujícího ve třídě AB, s minimální napěťovou nesymetrií, včetně návrhu topologie navrženéh...

  8. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus.

    Science.gov (United States)

    Mósena, Ana Cristina S; Cibulski, Samuel P; Weber, Matheus N; Silveira, Simone; Silva, Mariana S; Mayer, Fabiana Q; Roehe, Paulo M; Canal, Cláudio W

    2017-10-01

    'HoBi'-like viruses comprise a putative new species within the genus Pestivirus of the family Flaviviridae. 'HoBi'-like viruses have been detected worldwide in batches of fetal calf serum, in surveillance programs for bovine pestiviruses and from animals presenting clinical signs resembling bovine viral diarrhea virus (BVDV)-associated diseases. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses, two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species.

  9. Purification of a 166mHo solution by successive high-performance liquid chromatography and gravitational chromatography for half-life determination

    International Nuclear Information System (INIS)

    Florence Gueguen; Helene Isnard; Carole Bresson; Celine Caussignac; Guillaume Stadelmann; Anthony Nonell; Sebastien Mialle; Karsten Kossert; Frederic Chartier

    2014-01-01

    A methodology to purify a 166m Ho solution has been developed by a combination of activity and mass concentration measurements in order to further determine the 166m Ho half-life. The isobaric interference at m/q ≃ 166 requires Ho purification from non-natural Er with a high purification degree due to the large amount of Ho as opposed to Er. The Ho/Er separation was achieved using high-performance liquid chromatography on a semi-preparative column followed by purification on gravitational chromatography. The efficiency of the separation was evaluated after precise determination of the Er isotopic composition. The purification methodology enabled to separate Ho from Er. (author)

  10. Podnikatelský plán - Založení internetového obchodu se sportovní halovou obuví

    OpenAIRE

    Možnár, Aleš

    2014-01-01

    Diplomová práca sa zaoberá zostavením realistického podnikateľského plánu na založenie internetového obchodu so športovou halovou obuvou. Podkladom pre návrh podnikateľského plánu je detailná analýza tržného prostredia a vlastných zdrojov. Cieľom tejto práce je posúdiť realizovateľnosť podnikateľského plánu, odhaliť jeho úzke miesta a riziká. The diploma thesis deals with formulating a realistic business plan for setting up online shop with indoor sport footware. This business plan proposa...

  11. Lanthanide recognition: A Ho3+ potentiometric membrane sensor as a probe for determination of terazosin

    International Nuclear Information System (INIS)

    Ganjali, Mohammad Reza; Shams, Haniyeh; Faridbod, Farnoush; Hajiaghababaei, Leila; Norouzi, Parviz

    2009-01-01

    In this study, complexation of N'-(1-pyridin-2-ylmethylene)-2-furohydrazide (NFH) with some metal ions was investigated by conductometry and spectroscopy. Then, a Ho 3+ potentiometric membrane sensor was prepared based on the highly selective complexation between this ionophore and Ho 3+ . These new ionophores are more selective than the previously reported ones. In this work, for the first time, the proposed sensor was applied in indirect determination of the terazocine in its pharmaceutical formulation. The interest in constructing lanthanide sensors arises because they have similar ionic radii to calcium, but a higher charge density, which allows them to be used as probes to find the interactions between Ca 2+ and biologically important molecules.

  12. The generalized second law of thermodynamics in Hořava-Lifshitz cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Jamil, Mubasher [Center for Advanced Mathematics and Physics, National University of Sciences and Technology, H-12, Islamabad (Pakistan); Saridakis, Emmanuel N. [Department of Physics, University of Athens, GR-15771 Athens (Greece); Setare, M.R., E-mail: mjamil@camp.nust.edu.pk, E-mail: msaridak@phys.uoa.gr, E-mail: rezakord@ipm.ir [Department of Campus of Bijar, University of Kurdistan, Takht Street, Bijar (Iran, Islamic Republic of)

    2010-11-01

    We investigate the validity of the generalized second law of thermodynamics in a universe governed by Hořava-Lifshitz gravity. Under the equilibrium assumption, that is in the late-time cosmological regime, we calculate separately the entropy time-variation for the matter fluid and, using the modified entropy relation, that of the apparent horizon itself. We find that under detailed balance the generalized second law is generally valid for flat and closed geometry and it is conditionally valid for an open universe, while beyond detailed balance it is only conditionally valid for all curvatures. Furthermore, we also follow the effective approach showing that it can lead to misleading results. The non-complete validity of the generalized second law could either provide a suggestion for its different application, or act as an additional problematic feature of Hořava-Lifshitz gravity.

  13. Resistance-Based Ceramic Ho123 Ionic Conductor for Oxygen Gas Sensing

    Science.gov (United States)

    Idrus, L. H.; Yahya, A. K.

    2009-07-01

    Oxygen sensing properties of HoBa2Cu3O7-δ ceramic rods utilizing hot-spot phenomenon have been characterized. The rods were prepared from high purity oxides using the conventional solid-state reaction method. I-V characterization showed increase in output current with voltage before the appearance of the hot spot. After the appearance of the hot-spot, the output current strongly depended on oxygen partial pressure. The rod showed stable sensing characteristics with good electrical stability and reproducibility with higher sensitivity at low oxygen partial pressure. The sensing property is associated with the absorption of oxygen and dissociation into holes and oxide ions. Ho123 is more sensitive at pO2 below 20% compared to Er123 possibly due to differences in oxygen activation energy related to RE ionic radius.

  14. Resistance-Based Ceramic Ho123 Ionic Conductor for Oxygen Gas Sensing

    International Nuclear Information System (INIS)

    Idrus, L. H.; Yahya, A. K.

    2009-01-01

    Oxygen sensing properties of HoBa 2 Cu 3 O 7-δ ceramic rods utilizing hot-spot phenomenon have been characterized. The rods were prepared from high purity oxides using the conventional solid-state reaction method. I-V characterization showed increase in output current with voltage before the appearance of the hot spot. After the appearance of the hot-spot, the output current strongly depended on oxygen partial pressure. The rod showed stable sensing characteristics with good electrical stability and reproducibility with higher sensitivity at low oxygen partial pressure. The sensing property is associated with the absorption of oxygen and dissociation into holes and oxide ions. Ho123 is more sensitive at pO 2 below 20% compared to Er123 possibly due to differences in oxygen activation energy related to RE ionic radius.

  15. Direct In Situ Quantification of HO2 from a Flow Reactor.

    Science.gov (United States)

    Brumfield, Brian; Sun, Wenting; Ju, Yiguang; Wysocki, Gerard

    2013-03-21

    The first direct in situ measurements of hydroperoxyl radical (HO2) at atmospheric pressure from the exit of a laminar flow reactor have been carried out using mid-infrared Faraday rotation spectroscopy. HO2 was generated by oxidation of dimethyl ether, a potential renewable biofuel with a simple molecular structure but rich low-temperature oxidation chemistry. On the basis of the results of nonlinear fitting of the experimental data to a theoretical spectroscopic model, the technique offers an estimated sensitivity of reactor exit temperature range of 398-673 K. Accurate in situ measurement of this species will aid in quantitative modeling of low-temperature and high-pressure combustion kinetics.

  16. Glyoxal Oxidation Mechanism: Implications for the Reactions HCO + O2 and OCHCHO + HO2

    DEFF Research Database (Denmark)

    Fassheber, Nancy; Friedrichs, Gernot; Marshall, Paul

    2015-01-01

    density ranges. HCO concentration–time profiles have been detected by frequency modulation spectroscopy at a wavelength of λ = 614.752 nm. The temperature range of available direct rate constant data of the high-temperature key reaction HCO + O2 → CO + HO2 has been extended up to 1705 K and confirms.......73 kJ/mol/RT). At intermediate temperatures, the reaction OCHCHO + HO2 becomes more important. A detailed reanalysis of previous experimental data as well as more recent theoretical predictions favor the formation of a recombination product in contrast to the formerly assumed dominating and fast OH......-forming channel. Modeling results of the present study support the formation of HOCH(OO)CHO and provide a 2 orders of magnitude lower rate constant estimate for the OH channel. Hence, low-temperature generation of chain carriers has to be attributed to secondary reactions of HOCH(OO)CHO....

  17. Výpočet aerodynamiky závodního automobilu

    OpenAIRE

    Vančura, Jan

    2008-01-01

    Diplomové práce je zaměřena na výpočty aerodynamických charakteristik závodního automobilu. Popisuje metodu sestavení CFD modelu s využitím 3D scanneru ATOS a prostředí softwaru Pro Engineer. V průběhu vytváření této práce byly zjištěny vlivy přídavných aerodynamických prvků závodního automobilu na výsledné zatížení náprav. The main subject of this diploma thesis is computation of race car aerodynamics. It describes composition method of CFD model with utilization of 3D scanner ATOS and CA...

  18. An actively mode-locked Ho: YAG solid laser pumped by a Tm: YLF laser

    International Nuclear Information System (INIS)

    Yao, B Q; Cui, Z; Wang, J; Duan, X M; Dai, T Y; Du, Y Q; Yuan, J H; Liu, W

    2015-01-01

    A continuous wave mode-locked (CWML) Ho: YAG laser based on an acousto-optic modulator (AOM) pumped by a 1.9 μm Tm: YLF laser is demonstrated. This is the first time a report on an active CWML Ho: YAG laser has been published. A maximum output power of 1.04 W at 2097.25 nm in the CWML regime is obtained at a pump power of 13.2 W, corresponding to a slope efficiency of 13.3%. The mode-locked pulse repetition frequency is 82.76 MHz and the single pulse energy is 12.57 nJ. The mode-locked pulse width is 102 ps measured through a no-background second harmonic autocorrelation with KTP as the nonlinear crystal. Furthermore, the M 2 factor is calculated to be 1.146. (letter)

  19. Hořava–Lifshitz gravity inspired Bianchi-II cosmology and the mixmaster universe

    International Nuclear Information System (INIS)

    Giani, Leonardo; Kamenshchik, Alexander Y

    2017-01-01

    We study different aspects of the Hořava-Lifshitz inspired Bianchi-II cosmology and its relations with the mixmaster universe model. First, we present exact solutions for a toy model, where only the cubic in spatial curvature terms are present in the action; then we briefly discuss some exotic singularities, which can appear in this toy model. We study also the toy model where only the quadratic in spatial curvature terms are present in the action. We establish relations between our results and those obtained by using the Hamiltonian formalism. Finally, we apply the results obtained by studying Bianchi-II cosmology to describe the evolution of the mixmaster universe in terms of the Belinsky–Khalatnikov–Lifshitz formalism. Generally, our analysis gives some arguments in favour of the existence of the oscillatory approach to the singularity in a universe governed by the Hořava–Lifshitz type gravity. (paper)

  20. Magnetic properties and structural characterization of Sr2RuHoO6 complex perovskite

    International Nuclear Information System (INIS)

    Corredor, L.T.; Landínez Téllez, D.A.; Martínez Buitrago, D.; Albino Aguiar, J.; Roa-Rojas, J.

    2012-01-01

    We report an experimental study of the crystallographic lattice, morphologic characteristics and magnetic feature of Sr 2 RuHoO 6 complex perovskite, which is used as a precursor in the fabrication process of the superconducting ruthenocuprate RuSr 2 HoCu 2 O 8 . The samples were produced through the standard solid state reaction. A Rietveld refinement of experimental X-ray diffraction patterns shows that the material crystallizes in a monoclinic structure, which belongs to the P21/n (no.14) space group, with lattice parameters a=5.7719(6) Å, b=5.8784(5) Å, c=8.1651(9) Å, and tilt angle β=90.200°. Magnetic susceptibility measurements reveal the occurrence of an antiferromagnetic ordering for a Néel temperature T N =10.1 K. From the Curie-Weiss fitting of the paramagnetic regime we obtain an effective magnetic moment of 11.31 μ B .

  1. Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis

    Directory of Open Access Journals (Sweden)

    Liomba N

    2003-11-01

    Full Text Available Abstract Background As well as being inducible by haem, haemoxygenase -1 (HO-1 is also induced by interleukin-10 and an anti-inflammatory prostaglandin, 15d PGJ2, the carbon monoxide thus produced mediating the anti-inflammatory effects of these molecules. The cellular distribution of HO-1, by immunohistochemistry, in brain, lung and liver in fatal falciparum malaria, and in sepsis, is reported. Methods Wax sections were stained, at a 1:1000 dilution of primary antibody, for HO-1 in tissues collected during paediatric autopsies in Blantyre, Malawi. These comprised 37 acutely ill comatose patients, 32 of whom were diagnosed clinically as cerebral malaria and the other 5 as bacterial diseases with coma. Another 3 died unexpectedly from an alert state. Other control tissues were from Australian adults. Results Apart from its presence in splenic red pulp macrophages and microhaemorrhages, staining for HO-1 was confined to intravascular monocytes and certain tissue macrophages. Of the 32 clinically diagnosed cerebral malaria cases, 11 (category A cases had negligible histological change in the brain and absence of or scanty intravascular sequestration of parasitized erythrocytes. Of these 11 cases, eight proved at autopsy to have other pathological changes as well, and none of these eight showed HO-1 staining within the brain apart from isolated moderate staining in one case. Two of the three without another pathological diagnosis showed moderate staining of scattered monocytes in brain vessels. Six of these 11 (category A cases exhibited strong lung staining, and the Kupffer cells of nine of them were intensely stained. Of the seven (category B cases with no histological changes in the brain, but appreciable sequestered parasitised erythrocytes present, one was without staining, and the other six showed strongly staining, rare or scattered monocytes in cerebral vessels. All six lung sections not obscured by neutrophils showed strong staining of

  2. Influences of Seasoned Equity Offerings on Stock Return of Ho Chi Minh Market

    Directory of Open Access Journals (Sweden)

    Ho Viet Tien

    2013-01-01

    Full Text Available This paper investigated the impact of seasoned equity offerings (SEO on stock return of listed companies in Ho Chi Minh City market using the method “event study” which has been basically formed by Campbell, Lo, and MacKinlay (1997. The sample includes 332 SEOs from 2007 to 2010. The main findings show evidence that the Ho Chi Minh City market was not efficient in terms of the semi-strong form because the price has increased significantly on the ex-right date, day 0. In an opposite way, the market also reacted significantly negatively from T-4 to T-2. There are some significant impacts of timing on issue methods – equity right issues were in priority for favorable time and issues as “dividend by stocks” were chosen during unfavorable time. Keywords: Efficient Market Hypothesis, event study, Seasoned Equity Offerings

  3. Global Climate Change and Solutions for Urban Sustainability of Ho Chi Minh City, Vietnam

    Directory of Open Access Journals (Sweden)

    Dao Phan

    2015-03-01

    Full Text Available Ho Chi Minh City (HCMC, the largest city in Vietnam, is steadily growing, certainly towards a mega city in the near future. Like other mega cities at the boom stage, it has to face with serious environmental matters insolvable for many years. The situation may be worse under the effects of global climate change, geological subsidence due to non-standard construction and sea level rise. The situation of HCMC can be damaged or even broken by resonant effects of unsolved environmental matters and latent impacts of climate change. This article shows the challenges to the urban sustainable development under the duo effect of urban environmental matters and climate change in Ho Chi Minh City. Opportunities and strategic directions to overcome the challenges are also analyzed and recommended.

  4. Crystal fields of dilute Tb, Dy, Ho, or Er in Lu obtained by magnetization measurements

    International Nuclear Information System (INIS)

    Touborg, P.; Hog, J.

    1975-01-01

    Magnetization measurements are reported on single crystals of dilute Tb, Dy, Ho, or Er in Lu. These measurements were performed in the temperature range 1.5--100 K and field range 0--6 T and include measurements of initial susceptibility, isothermal and isofield magnetization, and basal-plane anisotropy. The results show features similar to the corresponding Y-R alloys, where R is a rare earth. Crystal-field and molecular-field parameters could be unabiguously deduced from the experimental data. The effects of crystal-field level broadening were investigated and demonstrated for Ho. Comparison of the Y-R and Lu-R results makes possible an estimate of the crystal-field parameters in the pure-rare-earth metals

  5. Tunable band gap in epitaxial ferroelectric Ho(Mn,Ga)O{sub 3} films

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Daesu; Noh, Tae Won, E-mail: twnoh@snu.ac.kr [Center for Correlated Electron Systems, Institute for Basic Science, Seoul 151-742 (Korea, Republic of); Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Choi, Woo Seok [Department of Physics, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of)

    2016-05-09

    Ferroelectrics have recently attracted attention as a new class of materials for use in optical and photovoltaic devices. We studied the electronic properties in epitaxially stabilized ferroelectric hexagonal Ho(Mn{sub 1−x}Ga{sub x})O{sub 3} (x = 0, 0.33, 0.67, and 1) thin films. Our films exhibited systematic changes in electronic structures, such as bandgap and optical transitions, according to the Ga concentration. In particular, the bandgap increased systematically from 1.4 to 3.2 eV, including the visible light region, with increasing Ga concentration from x = 0 to 1. These systematic changes, attributed to lattice parameter variations in epitaxial Ho(Mn{sub 1−x}Ga{sub x})O{sub 3} films, should prove useful for the design of optoelectronic devices based on ferroelectrics.

  6. Numerical Simulation of the Micro-explosion during Ho:YAG laser lithotripsy

    International Nuclear Information System (INIS)

    Yao Yucheng; Huang Chuyun; Xu Guowang; Yan Xudong; Wang Yanlin

    2011-01-01

    The micro-explosion during Ho:YAG laser lithotripsy may cause calculus fragmentation and migration. It plays an important role to the surgery. A numerical simulation of the micro-explosion during Ho:YAG laser lithotripsy has been developed. The explosion problem in water environment was solved by the Euler algorithm and the piecewise parabolic method (PPM) was selected in the calculation. This simulation investigated the explosion dynamics evolution in the lithotripsy area. The pressure and intensity of the calculus surface were calculated for different laser pulse energy and different distance between calculus and fiber tip. The calculation results indicate that the micro-explosion's properties are determined by the pulse energy, pulse duration and the water distance. Though Short pulse duration and large pulse energy cause high ablation efficiency, it mains more calculus retropulsion at the same time. The ideal surgery results need property laser parameters.

  7. High Power Q-Switched Dual-End-Pumped Ho:YAG Laser

    Energy Technology Data Exchange (ETDEWEB)

    Xiao-Ming, Duan; Ying-Jie, Shen; Tong-Yu, Dai; Bao-Quan, Yao; Wang Yue-Zhu, E-mail: xmduan@hit.edu.cn [National Key Laboratory of Tunable Laser Technology, Harbin Institute of Technology, Harbin 150001 (China)

    2012-09-15

    We report the high power acousto-optically Q-switched operation of a dual-end-pumped Ho:YAG laser at room temperature. For the Q-swithched mode, a maximum pulse energy of 2.4 mJ and a minimum pulse width of 23 ns at the repetition rate of 10 kHz are achieved, resulting in a peak power of 104.3 kW. The beam quality factor of M{sup 2} {approx} 1.5, which is demonstrated by a knife-edge method. In addition, the Ho:YAG laser is employed as a pumping source of ZGP optical parametric oscillator, and its total average output power is 13.2 W at 3.9 {mu}m and 4.4 {mu}m with a slope efficiency of 68.4%.

  8. Children thermal comfort in primary schools in Ho Chi Minh City in Vietnam

    OpenAIRE

    Le, Thi Ho Vi; Gillott, Mark C.; Rodrigues, Lucélia Taranto

    2017-01-01

    Indoor environmental quality significantly impacts on students’ performance and productivity, particularly thermal comfort levels. Currently in Vietnam, very few studies have dealt with the issue and the current trend is to install energy-intensive air-conditioning in primary schools as this is perceived as more comfortable. In this study, the authors investigated the users’ perceptions of thermal comfort in three primary schools in Ho Chi Minh City during the mid-season (September 2015) and ...

  9. Holographic dark energy with varying gravitational constant in Hořava-Lifshitz cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Setare, M.R. [Department of Physics, University of Kurdistan, Pasdaran Ave., Sanandaj (Iran, Islamic Republic of); Jamil, Mubasher, E-mail: rezakord@ipm.ir, E-mail: mjamil@camp.nust.edu.pk [Center for Advanced Mathematics and Physics, National University of Sciences and Technology, Rawalpindi, 46000 (Pakistan)

    2010-02-01

    We investigate the holographic dark energy scenario with a varying gravitational constant in a flat background in the context of Hořava-Lifshitz gravity. We extract the exact differential equation determining the evolution of the dark energy density parameter, which includes G variation term. Also we discuss a cosmological implication of our work by evaluating the dark energy equation of state for low redshifts containing varying G corrections.

  10. Thermal stability of LiNaR2F8 compounds (R=Ho-Lu, Y)

    International Nuclear Information System (INIS)

    Fedorov, P.P.; Medvedeva, L.V.; Bondareva, O.S.; Sobolev, B.P.

    1990-01-01

    Monoclinic pseudorhombic compound mentioned in the title are investigated. It is determined, that the compounds are stable within temperature narrow range: Ho - 575-693 degC, Er - 566-712deg C, Tm - 560-710 deg C, Yb - less than 685 deg C, Y - 580-712 deg C. Triangulation of LiF-NaF-YF 3 system is carried out

  11. Re-evaluation of the reactivity of hydroxylamine with O2-/HO2

    International Nuclear Information System (INIS)

    Bielski, B.H.J.; Arudi, R.L.; Cabelli, D.E.; Bors, W.

    1984-01-01

    The reactivity of hydroxylamine with HO 2 /O 2 - radicals was studied by pulse radiolysis and stopped-flow photolysis over a pH range of 1.1-10.5. Upper limits for the rate of reaction indicate that hydroxylamine, if it reacts at all, reacts at a very slow rate. Its use as an indicator for O 2 - and an assay for superoxide dismutase is, therefore, inappropriate. 20 references, 1 table

  12. Homozygous familial hypercholesterolemia (HoFH in Germany: an epidemiological survey

    Directory of Open Access Journals (Sweden)

    Walzer S

    2013-05-01

    Full Text Available S Walzer,1 K Travers,2 S Rieder,3 E Erazo-Fischer,3 D Matusiewicz41MArS Market Access and Pricing Strategy UG (hb, Weil am Rhein, Germany; 2United Biosource Corporation, Lexington, USA; 3Alcimed GmbH, Cologne, Germany; 4Institute for Health Care Management and Research, Faculty of Economics and Business Administration, University of Duisburg-Essen, Essen, GermanyIntroduction: In Europe a disease is recognized as rare if less than 1 in 2000 people suffer from the specific disease. In patients with familial homozygous hypercholesterolemia (HoFH the accumulation of low-density lipoprotein cholesterol (LDL-C leads to generalized atherosclerosis due to an insufficient functioning of the LDL-C receptors. Patients die early sometimes even in the mid-30s, from myocardial infarction or stroke. For the German population, insufficient epidemiological evidence exists.Methods: A systematic literature search in EMBASE and Medline was performed in conjunction with a targeted manual search for epidemiological HoFH studies. Additionally a nationwide survey was conducted in Germany in all identified apheresis- and lipid centers. The purpose of the survey was the validation of the systematic literature search results based on empirical (practice data.Results: In total 961 publications were found, 874 were excluded based on pre-defined exclusion criteria leaving only 87 for further review. After review of the identified abstracts (n = 87 23 publications were identified as epidemiological studies. Only one publication was found which reported a prevalence of 1:1,000,000. The qualitative survey among 187 physicians in Germany also revealed a low prevalence: 95 HoFH patients were identified in 35 centers.Conclusion: The estimated frequency of homozygous familial hypercholesterolemia patients in Germany is around 95 (1:860,000 and the disease should be recognized as rare according to the definition of the European Medical Agency.Keywords: epidemiology, homozygous

  13. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1.

    Science.gov (United States)

    Abdelbaset-Ismail, A; Borkowska-Rzeszotek, S; Kubis, E; Bujko, K; Brzeźniakiewicz-Janus, K; Bolkun, L; Kloczko, J; Moniuszko, M; Basak, G W; Wiktor-Jedrzejczak, W; Ratajczak, M Z

    2017-02-01

    As a crucial arm of innate immunity, the complement cascade (ComC) is involved both in mobilization of normal hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood and in their homing to BM. Despite the fact that ComC cleavage fragments alone do not chemoattract normal HSPCs, we found that leukemia cell lines as well as clonogenic blasts from chronic myeloid leukemia and acute myeloid leukemia patients respond robustly to C3 and C5 cleavage fragments by chemotaxis and increased adhesion. This finding was supported by the detection of C3a and C5a receptors in cells from human malignant hematopoietic cell lines and patient blasts at the mRNA (reverse transcriptase-polymerase chain reaction) and protein level (fluorescence-activated cell sorting), and by the demonstration that these receptors respond to stimulation by C3a and C5a by phosphorylation of p42/44 and p38 mitogen-activated protein kinases (MAPK), and protein kinase B (PKB/AKT). We also found that inducible heme oxygenase 1 (HO-1) is a negative regulator of ComC-mediated trafficking of leukemic cells, and that stimulation of leukemic cells by C3 or C5 cleavage fragments activates p38 MAPK, which downregulates HO-1 expression, rendering cells more mobile. We conclude that activation of the ComC in leukemia/lymphoma patients (for example, as a result of accompanying infections) enhances the motility of malignant cells and contributes to their spread in a p38 MAPK-HO-1-dependent manner. Therefore, inhibition of p38 MAPK or upregulation of HO-1 by small-molecule modulators would have a beneficial effect on ameliorating cell migration-mediated expansion of leukemia/lymphoma cells when the ComC becomes activated.

  14. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1

    Science.gov (United States)

    Abdelbaset-Ismail, A; Borkowska-Rzeszotek, S; Kubis, E; Bujko, K; Brzeźniakiewicz-Janus, K; Bolkun, L; Kloczko, J; Moniuszko, M; Basak, G W; Wiktor-Jedrzejczak, W; Ratajczak, M Z

    2017-01-01

    As a crucial arm of innate immunity, the complement cascade (ComC) is involved both in mobilization of normal hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood and in their homing to BM. Despite the fact that ComC cleavage fragments alone do not chemoattract normal HSPCs, we found that leukemia cell lines as well as clonogenic blasts from chronic myeloid leukemia and acute myeloid leukemia patients respond robustly to C3 and C5 cleavage fragments by chemotaxis and increased adhesion. This finding was supported by the detection of C3a and C5a receptors in cells from human malignant hematopoietic cell lines and patient blasts at the mRNA (reverse transcriptase-polymerase chain reaction) and protein level (fluorescence-activated cell sorting), and by the demonstration that these receptors respond to stimulation by C3a and C5a by phosphorylation of p42/44 and p38 mitogen-activated protein kinases (MAPK), and protein kinase B (PKB/AKT). We also found that inducible heme oxygenase 1 (HO-1) is a negative regulator of ComC-mediated trafficking of leukemic cells, and that stimulation of leukemic cells by C3 or C5 cleavage fragments activates p38 MAPK, which downregulates HO-1 expression, rendering cells more mobile. We conclude that activation of the ComC in leukemia/lymphoma patients (for example, as a result of accompanying infections) enhances the motility of malignant cells and contributes to their spread in a p38 MAPK–HO-1-dependent manner. Therefore, inhibition of p38 MAPK or upregulation of HO-1 by small-molecule modulators would have a beneficial effect on ameliorating cell migration-mediated expansion of leukemia/lymphoma cells when the ComC becomes activated. PMID:27451975

  15. Preparation and Quality Control of 166Ho-Boro-Macroaggregates for Radiosynoviorthesis

    Czech Academy of Sciences Publication Activity Database

    Kropáček, Martin; Melichar, František; Šrank, Jiří; Mirzajevová, Marcela; Klejzarová, Michaela; Kraft, O.; Kašpárek, R.; Záhlava, J.; Chodacki, A.

    2006-01-01

    Roč. 33, Suppl. 2 (2006), S327-S328 ISSN 1619-7070. [Annual Congress of the European Association of Nuclear Medicine. 01.10.2006-03.10.2006, Athens] R&D Projects: GA AV ČR(CZ) IQS10480501 Institutional research plan: CEZ:AV0Z10480505 Keywords : 166Ho- Boro -Macroaggregate * Radiosynoviorthesis Subject RIV: CH - Nuclear ; Quantum Chemistry

  16. Reaction rate constants of HO2 + O3 in the temperature range 233-400 K

    Science.gov (United States)

    Wang, Xiuyan; Suto, Masako; Lee, L. C.

    1988-01-01

    The reaction rate constants of HO2 + O3 were measured in the temperature range 233-400 K using a discharge flow system with photofragment emission detection. In the range 233-253 K, the constants are approximately a constant value, and then increase with increasing temperature. This result suggests that the reaction may have two different channels. An expression representing the reaction rate constants is presented.

  17. The system HoCl3-YCl3-H2O (25 deg C)

    International Nuclear Information System (INIS)

    Sorokina, A.A.; Yudina, N.G.

    1981-01-01

    By solubility method the system HoCl 3 -YCl 3 -H 2 O at 25 deg C has been studied. It is shown that in this system the continuous serie of solid solutions is formed. The liquid solutions of this system have been investigated by the isopiestic method. The values of activity coefficients, activity, free energy formation and excess free energy of solid solutions are calculated [ru

  18. Hořava-Lifshitz gravity and effective theory of the fractional quantum Hall effect

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Chaolun [Kadanoff Center for Theoretical Physics and Enrico Fermi Institute, University of Chicago,Chicago, Illinois 60637 (United States); Wu, Shao-Feng [Department of Physics, Shanghai University,Shanghai 200444 (China); Kadanoff Center for Theoretical Physics and Enrico Fermi Institute, University of Chicago,Chicago, Illinois 60637 (United States)

    2015-01-22

    We show that Hořava-Lifshitz gravity theory can be employed as a covariant framework to build an effective field theory for the fractional quantum Hall effect that respects all the spacetime symmetries such as non-relativistic diffeomorphism invariance and anisotropic Weyl invariance as well as the gauge symmetry. The key to this formalism is a set of correspondence relations that maps all the field degrees of freedom in the Hořava-Lifshitz gravity theory to external background (source) fields among others in the effective action of the quantum Hall effect, according to their symmetry transformation properties. We originally derive the map as a holographic dictionary, but its form is independent of the existence of holographic duality. This paves the way for the application of Hořava-Lifshitz holography on fractional quantum Hall effect. Using the simplest holographic Chern-Simons model, we compute the low energy effective action at leading orders and show that it captures universal electromagnetic and geometric properties of quantum Hall states, including the Wen-Zee shift, Hall viscosity, angular momentum density and their relations. We identify the shift function in Hořava-Lifshitz gravity theory as minus of guiding center velocity and conjugate to guiding center momentum. This enables us to distinguish guiding center angular momentum density from the internal one, which is the sum of Landau orbit spin and intrinsic (topological) spin of the composite particles. Our effective action shows that Hall viscosity is minus half of the internal angular momentum density and proportional to Wen-Zee shift, and Hall bulk viscosity is half of the guiding center angular momentum density.

  19. 330 mJ single-frequency Ho:YLF slab amplifier

    CSIR Research Space (South Africa)

    Strauss, HJ

    2013-04-01

    Full Text Available We report on a double-pass Ho:YLF slab amplifier which delivered 350 ns long single-frequency pulses of up to 330 mJ at 2064 nm, with a maximum M(sup2) of 1.5 at 50 Hz. It was end pumped with a diode-pumped Tm:YLF slab laser and seeded with up to 50...

  20. Beta dosimetry in intraperitoneal administration of 166Ho-chitosan complex

    International Nuclear Information System (INIS)

    Kim, E. H.; Lim, S. M.; Park, K. B.

    1998-01-01

    Intraperitoneal administration of radioisotopes is suggested to treat the metastatic ovarian cancer in the peritoneal cavity. Administering beta-emitting radioisotopes into the peritoneal cavity allows the maximum energy delivery to the cancerous cells of the peritoneal wall surface while sparing the normal cells located in deep site of the peritoneal wall. In this study, dose estimates of the peritoneal wall are provided to be used for prescribing the amount of 166 Ho-chitosan complex administered. The 166 Ho-chitosan complex diffused in the peritoneal fluid may attach to the peritoneal wall surface. The attachment fraction of 166 Ho-chitosan complex to the peritoneal wall surface is obtained by simulating the ascites with Fischer rats. Both volume source in the peritoneal fluid and the surface source over the peritoneal wall surface are counted for the contribution to the peritoneal wall dose. The Monte Carlo code EGS4 is used to simulate the energy transfer of the beta particles emitted from 166 Ho. A plane geometrical model of semi-infinite volume describes the peritoneal cavity and the peritoneal wall. A semi-infinite plane of 10 μm in thickness at every 1 mm of depth in the peritoneal wall is taken as the target in dose estimation. Greater than 98 percents of attachment fraction has been observed from the experiments with Fischer rats. Given 1.3 μCi/cm 2 and 2.4 μCi/ml of uniform activity density, absorbed dose is 123 Gy, 8.59 Gy, 3.00 Gy, 1.03 Gy, and 327 Gy at 0 mm, 1 mm, 2 mm, 3 mm, and 4 mm in depth to the peritoneal wall, respectively

  1. Complete and incomplete fusion dynamics in 20Ne + 165Ho system

    International Nuclear Information System (INIS)

    Linda, Sneha Bharti; Giri, Pankaj K.; Singh, D.; Kumar, Harish; Afzal Ansari, M.; Ali, Rahbar; Rashid, M.H.; Guin, R.; Das, S.K.

    2016-01-01

    In the present work, an attempt has been made to address some of the important aspects of CF and ICF dynamics for the system 20 Ne + 165 Ho in the projectile energy range 4-8 MeV/nucleon by employing the recoil catcher technique followed by off-line γ-ray spectroscopy. The excitation functions (EFs) of the two ERs 171 Ta and 168 Hf have been measured. In the present measurement no precursor decay contributions has been measured

  2. Optical spectroscopy of Ho{sup 3+}-doped SrWO{sub 4} scheelite crystal

    Energy Technology Data Exchange (ETDEWEB)

    Li Jianfu; Jia Guohua; Zhu Zhaojie; You Zhenyu; Wang Yan; Wu Baichang; Tu Chaoyang [Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry and National Engineering Research Center for Optoelectronic Crystalline Materials, Fuzhou, Fujian 350002 (China)

    2007-04-07

    Ho{sup 3+}-doped SrWO{sub 4} crystal was grown by the Czochralski method. The polarized absorption and emission spectra together with the fluorescent decay curve were measured at room temperature. The intensity parameters, radiative lifetimes and branching ratios were calculated based on the Judd-Ofelt theory. The stimulated emission cross-sections of the potential laser transitions were determined using the reciprocity method.

  3. Spin reorientation in HoIG investigated by means of Faraday effect

    International Nuclear Information System (INIS)

    Balanda, M.; Niziol, S.

    1979-01-01

    Faraday rotation measurements in pulsed magnetic fields up to 160 kOe and in low dc fields are carried out for Ho 3 Fe 5 O 12 near the compensation point. Transition to the canted phase is observed and the temperature dependence of the critical field determined. From the holmium sublattice magnetization and Hsub(cr) versus. T gradient, values of the two molecular field coefficients are determined. (author)

  4. Domácí měření krevního tlaku

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan

    2006-01-01

    Roč. 3, č. 3 (2006), s. 111-114 ISSN 1214-8687 R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : hypertenze * domácí měření krevního tlaku * typy tonometrů Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  5. Preoperative radiotherapy (RT) for prevention of heterotopic ossification (HO) after total hip replacement

    International Nuclear Information System (INIS)

    Heyd, R.; Schopohl, B.; Boettcher, H.D.; Kirchner, J.

    1997-01-01

    Preliminary results of a prospective study which investigates the efficacy of preoperative radiotherapy (RT) for prevention of heterotopic ossification (HO) after total hip arthroplasty are summarized. A total number of 20 hip joints (18 patients) were irradiated with a single dose of 6.0 Gy Brooker grade II). The functional outcome quantified with the Harris score was improved by an average of 37.9 points. The authors conclude that preoperative RT is an effective alternative for postoperative irradiation. (orig.) [de

  6. Role and molecular mechanism of HO-1-mediated NF-κB modulation in fibrosis progression of nonalcoholic steatohepatitis

    Directory of Open Access Journals (Sweden)

    NAN Yuemin

    2013-05-01

    Full Text Available ObjectiveTo investigate the potential effects and molecular mechanisms of heme oxygenase-1 (HO-1-mediated modulation of nuclear factor-kappa B (NF-κB, and its downstream activation of intercellular adhesion molecule 1 (ICAM-1 and platelet derived growth factor (PDGF, in fibrosis progression of non-alcoholic steatohepatitis (NASH using the methionine and choline deficient (MCD mouse model of NASH. Methods Forty C57BL/6J male mice (18-20 g were randomly divided into four groups (n=10 each: NASH model group, administered the MCD diet; HO-1 agonist group, administered the MCD diet with intraperitoneal (ip injections of hemin (30 μmol/kg every other day; HO-1 inhibitor group, administered the MCD diet with ip injections of zinc protoporphyrin (ZnPP-IX; 20 μmol/kg every other day; and control group, administered a methionine and choline sufficient (MCS diet, without agonist nor inhibitor injections. After eight weeks, the mice were sacrificed and resected liver tissues used to assess successful model establishment by histological analysis (hematoxylin-eosin and Masson staining and the differential mRNA expression of HO-1, NF-κB, ICAM-1, and PDGF by real-time quantitative PCR (GAPDH normalized and protein expression of HO-1 and PDGF by western blotting ( β-actin normalized. Significance of an intergroup difference was assessed by single-factor analysis of variance test, and the Student-Newman-Keuls test was used for pairwise comparisons. ResultsThe NASH model group showed the appropriate histologic features of hepatic steatosis, necroinflammation and fibrogenesis, while the control group showed normal lobular architecture. In addition, the NASH model group showed significantly higher expression of HO-1, NF-κB, ICAM-1 and PDGF mRNA (all P<0.05, and concomitant increases in HO-1 and PDGF protein. The group treated with HO-1 agonist showed significant down-regulation of the NASH-induced NF-κB, ICAM-1 and PDGF expressions, while the opposite

  7. Magnetic ordering in Ho-doped Bi{sub 2}Te{sub 3} topological insulator

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, A.I.; Van der Laan, G.; Hesjedal, T. [Magnetic Spectroscopy Group, Diamond Light Source, Didcot (United Kingdom); Harrison, S.E. [Department of Physics, Clarendon Laboratory, University of Oxford (United Kingdom); Department of Electrical Engineering, Stanford University, Stanford, CA (United States); Collins-McIntyre, L.J. [Department of Physics, Clarendon Laboratory, University of Oxford (United Kingdom)

    2016-06-15

    We investigate the magnetic properties of Ho-doped Bi{sub 2}Te{sub 3} thin films grown by molecular beam epitaxy. Analysis of the polarized X-ray absorption spectra at the Ho M{sub 5} absorption edge gives an effective 4f magnetic moment which is ∝45% of the Hund's rule ground state value. X-ray magnetic circular dichroism (XMCD) shows no significant anisotropy, which suggests that the reduced spin moment is not due to the crystal field effects, but rather the presence of non-magnetic or antiferromagnetic Ho sites. Extrapolating the temperature dependence of the XMCD measured in total electron yield and fluorescence yield mode in a field of 7 T gives a Curie-Weiss temperature of and vartheta;{sub CW} ∼ -30 K, which suggests antiferromagnetic ordering, in contrast to the paramagnetic behavior observed with SQUID magnetometry. From the anomaly of the XMCD signal at low temperatures, a Neel temperature T{sub N} between 10 K and 25 K is estimated. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  8. The normal and inverse magnetocaloric effect in RCu2 (R=Tb, Dy, Ho, Er) compounds

    International Nuclear Information System (INIS)

    Zheng, X.Q.; Xu, Z.Y.; Zhang, B.; Hu, F.X.; Shen, B.G.

    2017-01-01

    Orthorhombic polycrystalline RCu 2 (R=Tb, Dy, Ho and Er) compounds were synthesized and the magnetic properties and magnetocaloric effect (MCE) were investigated in detail. All of the RCu 2 compounds are antiferromagnetic (AFM) ordered. As temperature increases, RCu 2 compounds undergo an AFM to AFM transition at T t and an AFM to paramagnetic (PM) transition at T N . Besides of the normal MCE around T N , large inverse MCE around T t was found in TbCu 2 compound. Under a field change of 0–7 T, the maximal value of inverse MCE is even larger than the value of normal MCE around T N for TbCu 2 compound. Considering of the normal and inverse MCE, TbCu 2 shows the largest refrigerant capacity among the RCu 2 (R=Tb, Dy, Ho and Er) compounds indicating its potential applications in low temperature multistage refrigeration. - Highlights: • Large inverse magnetocaloric effect is observed in TbCu 2 compound. • The AFM to AFM transition is observed in RCu 2 (R=Tb, Dy, Ho, Er) compounds. • The MCE performance of TbCu 2 compound is evaluated in a more comprehensively way.

  9. Water radiolysis in extreme conditions of temperature and LET. Scavenging of HO. by Br- ions

    International Nuclear Information System (INIS)

    Saffre, Dimitri

    2011-01-01

    The purpose of this thesis is to contribute to the understanding of the oxidation mechanism of Br - in which the HO . radical is involved. The HO . radiolytic yield is strongly connected with the oxidation yield of Br - , and therefore we have studied the influence of different physical and chemical parameters on this global yield: temperature, LET, dose rate, pH, saturation gas. The solutions have been irradiated with 4 types of ionizing rays: X-rays (from 13 to 18 keV), electrons (from 7 to 10 MeV), C 6+ -ions beam of 975 MeV and He 2+ -ions beam of 70 MeV. The development of an optical autoclave with solution flow, compatible with high LET ionizing rays has allowed us conduct the first experiments at constant high LET and high temperature. This cell has turned out to be compatible with the picosecond pump-probe experiments performed with the ELYSE accelerator. The HO . scavenging yield has been, therefore, estimated at both high LET and high temperature. A better understanding of the Br - oxidation mechanism has been achieved, in acid medium, in particular, by comparing the kinetics results with Monte Carlo Simulations for time scales inferior to the microsecond and with Chemsimul for the stable products (Br 2 .- and Br 3 - formations). (author) [fr

  10. Vliv teplotní historie na vztah mezi strukturou a vlastnostmi orientovaného polypropylenu

    OpenAIRE

    Sadílek, Jiří

    2010-01-01

    Tato práce se zabývá tím, jak teplotní historie ovlivňuje strukturu a vlastnosti polypropylenových monofilů s různým stupněm orientace a také výchozího isotropního neorientovaného polypropylenu. Pojmem teplotní historie jsou v této práci označeny teplotní režimy, které se pohybují od teploty alfa relaxace (T?) po teplotu tání polypropylenu (Tm). Práce je rozdělena do tří částí. V první části jsou popsány změny dynamických mechanických vlastností, pevnosti, tažnosti a modulu pružnosti polyprop...

  11. Single crystal growth and anisotropic magnetic properties of HoAl2Ge2

    Science.gov (United States)

    Matin, Md.; Mondal, Rajib; Thamizhavel, A.; Provino, A.; Manfrinetti, P.; Dhar, S. K.

    2018-05-01

    We have grown a single crystal of HoAl2Ge2, which crystallizes in the hexagonal CaAl2Si2 type structure with Ho ions in the trigonal coordination in the ab plane. The data obtained from the bulk measurement techniques of magnetization, heat capacity and transport reveal that HoAl2Ge2 orders antiferromagnetically at TN ˜6.5 K. The susceptibility below TN and isothermal magnetization at 2 K indicate the ab plane as the easy plane of magnetization. Heat capacity data reveal a prominent Schottky anomaly with a broad peak centered around 25 K, suggesting a relatively low crystal electric field (CEF) splitting. The electrical resistivity reveals the occurrence of a superzone gap below TN. The point charge model of the CEF is applied to the magnetization and the heat capacity data. While a good fit to the paramagnetic susceptibility is obtained, the CEF parameters do not provide a satisfactory fit to the isothermal magnetization at 2 K and the Schottky anomaly.

  12. Influence of low Co substitution on magnetoelastic properties of HoFe11Ti intermetallic compound

    International Nuclear Information System (INIS)

    Motevalizadeh, L.; Tajabor, N.; Sanavi Khoshnoud, D.; Fruchart, D.; Pourarian, F.

    2012-01-01

    The thermal expansion and magnetostriction of HoFe 11−x Co x Ti (x=0, 0.3, 0.7 and 1) intermetallic compounds were measured, using the strain gauge method in the temperature range 77–590 K under applied magnetic fields up to 1.5 T. Results show that for samples with x=0 and 0.3, both linear thermal expansion and linear thermal expansion coefficient exhibit anomalies below the Curie temperature. Below room temperature, the spontaneous volume magnetostriction decreases with Co content. For all compounds studied, the anisotropic magnetostriction shows similar behaviour in the measured temperature range. The magnetostriction compensation occurs above room temperature in all samples. The volume magnetostriction shows a linear dependence on the applied field and by approaching the Curie temperature this trend changes to parastrictive behaviour. The results of the spontaneous magnetostriction are discussed based on the local magnetic moment model. The contribution of magnetostriction attributed to the magnetic sublattices R and T (Fe or Co) is discussed. - Highlights: ► Magnetostriction of HoFe 11−x Co x Ti have been measured by using strain gauge method. ► The measurement was carried in 77–590 K under applied magnetic fields up to 1.5 T. ► Spontaneous volume magnetostriction and Invar effect decrease with Co substitution. ► Ho sublattice has negative contribution to spontaneous volume magnetostriction. ► Absolute values of anisotropic magnetostriction decrease slightly with Co content.

  13. Rekonstrukce sportovního areálu - zdravotně technické instalace

    OpenAIRE

    Kohutek, Ivo

    2013-01-01

    Tato bakalářská práce se zabývá zdravotně technickými instalacemi v čás-ti rekonstruovaného sportovního objektu STARS v městě Třinci. Řešená část objektu je jed-nopodlažní s užitným podzemním podlažím. V teoretické části se věnuje druhům vodovodních armatur a jejich vlivu na úsporu pitné vody. Projektová část následně řeší výpočet, di-menzování vnitřního vodovodu a rozvodů vnitřní kanalizace v rekonstruované části objektu. This bachelor's thesis is focused on medicinal technical instalatio...

  14. New agegraphic dark energy in Hořava-Lifshitz cosmology

    International Nuclear Information System (INIS)

    Jamil, Mubasher; Saridakis, Emmanuel N.

    2010-01-01

    We investigate the new agegraphic dark energy scenario in a universe governed by Hořava-Lifshitz gravity. We consider both the detailed and non-detailed balanced version of the theory, we impose an arbitrary curvature, and we allow for an interaction between the matter and dark energy sectors. Extracting the differential equation for the evolution of the dark energy density parameter and performing an expansion of the dark energy equation-of-state parameter, we calculate its present and its low-redshift value as functions of the dark energy and curvature density parameters at present, of the Hořava-Lifshitz running parameter λ, of the new agegraphic dark energy parameter n, and of the interaction coupling b. We find that w 0 = −0.82 +0.08 −0.08 and w 1 = 0.08 +0.09 −0.07 . Although this analysis indicates that the scenario can be compatible with observations, it does not enlighten the discussion about the possible conceptual and theoretical problems of Hořava-Lifshitz gravity

  15. Identification and epidemiology of a rare HoBi-like pestivirus strain in Bangladesh.

    Science.gov (United States)

    Haider, N; Rahman, M S; Khan, S U; Mikolon, A; Gurley, E S; Osmani, M G; Shanta, I S; Paul, S K; Macfarlane-Berry, L; Islam, A; Desmond, J; Epstein, J H; Daszak, P; Azim, T; Luby, S P; Zeidner, N; Rahman, M Z

    2014-06-01

    The genus pestivirus of the family flaviviridae consists of four recognized species: bovine viral diarrhoea virus 1 (BVDV-1), bovine viral diarrhoea virus 2 (BVDV-2), classical swine fever virus and border disease virus. A new putative pestivirus species tentatively named as either 'HoBi-like pestivirus' or BVDV-3 has recently been identified in Brazil, Italy and Thailand. Despite reports of serological evidence of BVDV in Bangladesh, the types of the virus circulating in cattle have not been identified. We conducted surveillance in cattle from May 2009 to August 2010 in three government veterinary hospitals to characterize BVDV in cattle of Bangladesh. We tested serum for BVDV using an antigen-capture ELISA. Of 638 cattle samples, 3% (16/638) tested positive for BVDV antigen. The ELISA-positive samples were selected for further molecular detection and characterization of BVDV. Molecular analysis of the partial 5' untranslated region (UTR) nucleotide sequences of BVDV-positive samples identified the rare HoBi-like pestivirus or BVDV-3 virus circulating in cattle of Bangladesh. The identification of this rare HoBi-like pestivirus or BVDV-3 strain in Bangladesh warrants further surveillance to evaluate its impact on livestock production. © 2014 Blackwell Verlag GmbH.

  16. Návrh strategie pro vybudování ziskového víceúrovňového podnikání

    OpenAIRE

    Mokrý, Martin

    2010-01-01

    Předložená diplomová práce se zabývá tématem víceúrovňového marketingu jako oboru pro samostatné podnikání jednotlivce. Posuzuje pozitiva a negativa této metody podnikání a rozdílnost od podvodných modelů. Diplomová práce se zaměřuje zejména na navržení konkrétních postupů vedoucích k vybudování stabilního příjmu v tomto odvětví a k tomu využívá současné poznatky o víceúrovňovém marketingu, základní metody určování kompetencí, kompetenčních modelů a koučování. This diploma thesis deals wit...

  17. 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"

    Directory of Open Access Journals (Sweden)

    Lemieux Bruno

    2010-12-01

    Full Text Available Abstract Background In cancer cells the three-dimensional (3D telomere organization of interphase nuclei into a telomeric disk is heavily distorted and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH reveals a major impact of nuclear telomere dynamics during the transition form mononuclear Hodgkin (H to diagnostic multinuclear Reed-Sternberg (RS cells. In vitro and in vivo formation of RS-cells is associated with the increase of very short telomeres including "t-stumps", telomere loss, telomeric aggregate formation and the generation of "ghost nuclei". Results Here we analyze the 3D telomere dynamics by Q-FISH in the novel Hodgkin cell line U-HO1 and its non-receptor protein-tyrosine phosphatase N1 (PTPN1 stable transfectant U-HO1-PTPN1, derived from a primary refractory Hodgkin's lymphoma. Both cell lines show equally high telomerase activity but U-HO1-PTPN differs from U-HO1 by a three times longer doubling time, low STAT5A expression, accumulation of RS-cells (p As expected, multinuclear U-HO1-RS-cells and multinuclear U-HO1-PTPN1-RS-cells differ from their mononuclear H-precursors by their nuclear volume (p Conclusion Abundant RS-cells without additional very short telomeres including "t-stumps", high rate of apoptosis, but low STAT5A expression, are hallmarks of the U-HO1-PTPN1 cell line. These characteristics are independent of telomerase activity. Thus, PTPN1 induced dephosphorylation of STAT5 with consecutive lack of Akt/PKB activation and cellular arrest in G2, promoting induction of apoptosis, appears as a possible pathogenetic mechanism deserving further experimental investigation.

  18. Measurement of thermal neutron cross-section and resonance integral for the 165Ho(n,γ) 166gHo reaction using electron linac-based neutron source

    Science.gov (United States)

    Nguyen, Van Do; Pham, Duc Khue; Kim, Tien Thanh; Kim, Guinyun; Lee, Manwoo; Kim, Kyung Sook; Kang, Heung-Sik; Cho, Moo-Hyun; Ko, In Soo; Namkung, Won

    2011-01-01

    The thermal neutron cross-section and the resonance integral of the 165Ho(n,γ) 166gHo reaction have been measured by the activation method using a 197Au(n,γ) 198Au monitor reaction as a single comparator. The high-purity natural Ho and Au foils with and without a cadmium shield case of 0.5 mm thickness were irradiated in a neutron field of the Pohang neutron facility. The induced activities in the activated foils were measured with a calibrated p-type high-purity Ge detector. The correction factors for the γ-ray attenuation ( Fg), the thermal neutron self-shielding ( Gth), the resonance neutron self-shielding ( Gepi) effects, and the epithermal neutron spectrum shape factor ( α) were taken into account. The thermal neutron cross-section for the 165Ho(n,γ) 166gHo reaction has been determined to be 59.7 ± 2.5 barn, relative to the reference value of 98.65 ± 0.09 barn for the 197Au(n,γ) 198Au reaction. By assuming the cadmium cut-off energy of 0.55 eV, the resonance integral for the 165Ho(n,γ) 166gHo reaction is 671 ± 47 barn, which is determined relative to the reference value of 1550 ± 28 barn for the 197Au(n,γ) 198Au reaction. The present results are, in general, good agreement with most of the previously reported data within uncertainty limits.

  19. Magnetic properties of pure and Fe doped HoCrO{sub 3} thin films fabricated via a solution route

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Shiqi; Sauyet, Theodore [Department of Physics, University of Connecticut, Storrs, CT 06269 (United States); Guild, Curt [Department of Chemistry, University of Connecticut, Storrs, CT 06269 (United States); Suib, S.L. [Department of Chemistry, University of Connecticut, Storrs, CT 06269 (United States); Institute of Materials Science, University of Connecticut, Storrs, CT 06269 (United States); Jain, Menka, E-mail: menka.jain@uconn.edu [Department of Physics, University of Connecticut, Storrs, CT 06269 (United States); Institute of Materials Science, University of Connecticut, Storrs, CT 06269 (United States)

    2017-04-15

    Multiferroic properties of orthorhombically distorted perovskite rare-earth chromites, such as HoCrO{sub 3}, are being investigated extensively in recent years. In the present work, we report on the effect of Fe substitution on the magnetic properties of HoCrO{sub 3} thin films. Thin films of HoCrO{sub 3} and HoCr{sub 0.7}Fe{sub 0.3}O{sub 3} were fabricated via a solution route on platinized silicon substrates. Structural properties of the films were evaluated by X-ray diffraction and Raman spectroscopy techniques. The surface morphology and cross-sections of the films were examined using scanning electron microscopy. Optical band gaps of pure and Fe doped HoCrO{sub 3} films are found to be 3.45 eV and 3.39 eV, respectively. The magnetization measurements show that the Néel temperatures (where Cr{sup 3+} orders) for the HoCrO{sub 3} and HoCr{sub 0.7}Fe{sub 0.3}O{sub 3} films are 134 and 148 K, respectively. In a magnetic field of 2 T, the maximum entropy change and relative cooling power, two parameters to evaluate the magnetocaloric properties of a material, were 0.813 J/kg K at 11 K and 21.1 J/kg for HoCrO{sub 3} film, in comparison with 0.748 J/kg K at 15 K and 26.8 J/kg for HoCr{sub 0.7}Fe{sub 0.3}O{sub 3} film. To our knowledge, this is the first work exploring the band gap and magnetocaloric properties of rare-earth chromite thin films. These findings should inspire the development of rare-earth chromite thin films for temperature control of nanoscale electronic devices and sensors in the low temperature region (< 30 K). - Highlights: • Phase-pure HoCrO{sub 3} and HoCr{sub 0.7}Fe{sub 0.3}O{sub 3}films were fabricated on platinized Sivia a solution route. • This is the first work on the exploration of band gap and magnetocaloric properties of rare-earth chromitefilms. • From 0-2 T, maximum entropy change for the HoCrO{sub 3} film was 0.813 J/kg K at 11 K.From 0-2 T, maximum entropy change for HoCr{sub 0.7}Fe{sub 0.3}O{sub 3} film was 0.748 J/kg K at 15

  20. Labeling of biotin with 166Dy/166Ho as a stable in vivo generator system

    International Nuclear Information System (INIS)

    Ferro-Flores, G.; Monroy-Guzman, F.; Tendilla, J.I.; Garcia-Salinas, L.; Villarreal-Barajas, J.E.; Arteaga-Murphy, C.

    2002-01-01

    Biotin (cis-tetrahydro-2-oxothieno[3,4-d]imidazoline-4-valeric acid) is a 244 Da vitamin found in low concentration in blood and tissue (vitamin H). The aim of this work was to synthesize 166 Dy/ 166 Ho-DTPA-bisBiotin to evaluate its potential as a new radiopharmaceutical for targeted radiotherapy. Dysprosium-166/ holmium-166 chloride was obtained by neutron irradiation of 20 mg of enriched Dy 2 O 3 ( 164 Dy, 99 %, from Oak Ridge NL) in a Triga Mark III reactor at a flux in the central thimble of 3.10 13 n. cm -2 s -1 for 20 h. Following irradiation, the target was allowed to decay for 2 days, then 100 μL of 12 N chloride acid were added and stirred for 1 min. To this solution was added 500 μL of injectable water and the whole was also stirred for 2 min. The average radioactive concentration was 332 MBq/ml. The biotin used in this investigation was covalently conjugated to diethylenetriamine pentaacetic acid (DTPA) through the use of the cyclic anhydride and lysine conjugate to biotin (biocytin) to produce DTPA-α,ω-bis(biocytin amide)(DTPA-bisBiotin). Sterile and apyrogenic V-vial was prepared to contain 2.0 mg (1.9 x 10 -3 mmol) of the DTPA-bisbiotin compound in 1.0 ml of 0.05 M bicarbonate buffer (pH 8.0) and then 20 μL of 166 Dy2Cl3 solution were added to the preparation. Thin Layer Chromatography aluminum cellulose sheets were utilised as the stationary phase and a ternary mixture of methanol:water:ammonium hydroxide (20:40:2) as the mobile phase. 166 Dy/ 166 Ho-DTPA-bisBiotin travelled with the solvent front R f 0.9-1.0 and the Dy +3 /Ho +3 species remained at the origin (R f = 0). The biological integrity of labelled biotin was achieved evaluating its avidity for avidin in an agarose column. Stability studies against dilution were carried out by diluting the radiocomplex solution with saline and with human serum at 310 K. After 10 min and 24 h the radiochemical purity of each 166 Dy/ 166 Ho complex solution was determined by TLC. The complex 166 Dy/ 166

  1. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    International Nuclear Information System (INIS)

    Pecorelli, Alessandra; Bocci, Velio; Acquaviva, Alessandra; Belmonte, Giuseppe; Gardi, Concetta; Virgili, Fabio; Ciccoli, Lucia; Valacchi, Giuseppe

    2013-01-01

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 μg/mL O 3 per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H 2 O 2 ) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ► Endothelial HO1 is upregulated by ozonated plasma ► This activation is induced by NRF2 and it is ERK independent. ► 4HNE and H 2 O 2 are the main molecules involved in this process. ► Ozonated plasma induced a hormetic effect ► Combination of orthodox medicine and ozonated plasma can be a useful treatment

  2. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 μg/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ► Endothelial HO1 is upregulated by ozonated plasma ► This activation is induced by NRF2 and it is ERK independent. ► 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ► Ozonated plasma induced a hormetic effect ► Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  3. Heterogeneous photochemistry of imidazole-2-carboxaldehyde: HO2 radical formation and aerosol growth

    Directory of Open Access Journals (Sweden)

    L. González Palacios

    2016-09-01

    Full Text Available The multiphase chemistry of glyoxal is a source of secondary organic aerosol (SOA, including its light-absorbing product imidazole-2-carboxaldehyde (IC. IC is a photosensitizer that can contribute to additional aerosol ageing and growth when its excited triplet state oxidizes hydrocarbons (reactive uptake via H-transfer chemistry. We have conducted a series of photochemical coated-wall flow tube (CWFT experiments using films of IC and citric acid (CA, an organic proxy and H donor in the condensed phase. The formation rate of gas-phase HO2 radicals (PHO2 was measured indirectly by converting gas-phase NO into NO2. We report on experiments that relied on measurements of NO2 formation, NO loss and HONO formation. PHO2 was found to be a linear function of (1 the [IC]  ×  [CA] concentration product and (2 the photon actinic flux. Additionally, (3 a more complex function of relative humidity (25 %  <  RH  <  63 % and of (4 the O2 ∕ N2 ratio (15 %  <  O2 ∕ N2  <  56 % was observed, most likely indicating competing effects of dilution, HO2 mobility and losses in the film. The maximum PHO2 was observed at 25–55 % RH and at ambient O2 ∕ N2. The HO2 radicals form in the condensed phase when excited IC triplet states are reduced by H transfer from a donor, CA in our system, and subsequently react with O2 to regenerate IC, leading to a catalytic cycle. OH does not appear to be formed as a primary product but is produced from the reaction of NO with HO2 in the gas phase. Further, seed aerosols containing IC and ammonium sulfate were exposed to gas-phase limonene and NOx in aerosol flow tube experiments, confirming significant PHO2 from aerosol surfaces. Our results indicate a potentially relevant contribution of triplet state photochemistry for gas-phase HO2 production, aerosol growth and ageing in the atmosphere.

  4. Chilean experience in production of therapeutic radiopharmaceuticals labelled with 153Sm and 166Ho

    International Nuclear Information System (INIS)

    Chandia, M.; Gil, M.G.; Tomicic, M.; Araya, G.; Olea, E.; Chong, G.

    1998-01-01

    153 Samarium ( 153 Sm) and 166 Holmium ( 166 Ho) were produced at the Nuclear Center of La Reina Research Reactor, Chilean Nuclear Energy Commission. 153 Sm-EDTMP (Ethylenediaminetetramethylene Phosphonate) used for clinical trial of therapy for painful skeletal metastases and labeled particles such as 166 Ho-FHMA (ferric hydroxide macroagregattes) and 153 Sm-HAP (hydroxiapatite particles) used for radiation synevectomy, were labeled. Radionuclide purity of both radionuclides was analyzed by gamma spectrometry using a multichannel gamma spectrometer. Radiochemical labeled reaction parameters of 153 Sm-EDTMP such as: Sm/EDTMP molar ratio, 153 Sm specific activity, labeled pH and temperature, were determined in order to get high radiolabeling yields. Radiochemical Quality Controls of 153 Sm-EDTMP using different chromatographic systems were carried out in order to determine labeling yields. Bodistribution studies were achieved in mice by dissection of animals and by autoradiography of histological slices in rats, after 2h post injection. 153 Sm-HAP and 166 Ho-FHMA labeled particles were prepared using the methods described. Radiochemical purity, in case of radiolabeled particles was carried out by centrifugation, measuring activity in the supernatant and in particles pellet. Physical parameters, such as particle size and range of the radiopharmaceuticals based on particles labeling were evaluated in order to determine the ideal conditions to obtain particles size range between 10 - 40μ. In vitro labeling stability for over seven days and wash out activity by incubation in human synovial fluid after 6 and 24h post labeling, was also studied. 153 Sm-EDTMP was easily labeled with a Radiochemical purity over 99.5% and stable for over 7 days. Biodistribution studies in mice give more than 50% of ID uptake in bone and less than 0,1% in liver this was correlated by autoradiographic image. 153 Sm-HAP and 166 Ho-FHMA were also labeling obtaining radiochemical purity over 95

  5. Preparation of 166 Dy/166 Ho DTPA-bis biotin as a system of In vivo generator

    International Nuclear Information System (INIS)

    Jimenez V, M.R.

    2003-01-01

    The objective of this work was to synthesize the complex 166 Dy/ 166 Ho - diethylen triamine pentaacetic-bis Biotin ( 166 Dy/ 166 Ho DTPA-bis Biotin) to evaluate its potential as a new radiopharmaceutical in directed radiotherapy. The Dysprosium-166 was obtained for neutron irradiation of 164 Dy 2 0 3 in the TRIGA Mark III reactor. The labelled was carried out in aqueous solution to p H 8.0 for addition of 166 Dy Cl 3 to the diethylen triamine pentaacetic-α, ω-bis Biotin (DTPA-bis Biotin). The radiochemical purity was determined for HPLC and ITLC. The biological integrity of the marked biotin is evaluated by the biological recognition of the avidin for HPLC - molecular exclusion with and without avidin addition. The studies of stability in vitro were made in dilutions of saline solution to 0.9% and with human serum at 37 C incubated 1 and 24 hours. The complex 166 Dy/ 166 Ho DTPA-bis Biotin was obtained with a radiochemical purity of 99.1 ± 0.6%. The biological recognition of the complex 166 Dy/ 166 Ho DTPA-bis Biotin for the avidin it doesn't affect the labelling procedure. The studies in vitro demonstrated that the 166 Dy/ 166 Ho DTPA-bis Biotin is stable after the dilution in saline solution and in human serum that there is not translocation of the one radionuclide subsequent son to the beta decay of the 166 Dy that could produce the 166 Ho 3+ liberation. The studies of Biodistribution in healthy mice demonstrated that the one complex 166 Dy/ 166 Ho DTPA-bis Biotin have a high renal distribution. In conclusion the radiolabelled biotin in this investigation has the appropriate properties to be used as an In vivo generator system stable for directed radiotherapy. (Author)

  6. Recoil and conversion electron considerations of the {sup 166}Dy/{sup 166}Ho in vivo generator

    Energy Technology Data Exchange (ETDEWEB)

    Zeevaart, J.R. [North-West Univ., Mmabatho (South Africa). CARST; Szuecs, Z. [Nesca (South African Nuclear Energy Corporation Ltd.), Pretoria (South Africa). Radiochemistry; Hungarian Academy of Sciences, Debrecen (Hungary). Inst. of Nuclear Research; Takacs, S.; Jarvis, N. [Hungarian Academy of Sciences, Debrecen (Hungary). Inst. of Nuclear Research; Jansen, D. [Nesca (South African Nuclear Energy Corporation Ltd.), Pretoria (South Africa). Radiochemistry

    2012-07-01

    The use of radionuclides as potential therapeutic radiopharmaceuticals is increasingly investigated. An important aspect is the delivery of the radionuclide to the target, i.e. the radionuclide is not lost from the chelating agent. For in vivo generators, it is not only the log K of complexation between the metal ion and the chelator that is important, but also whether the daughter radionuclide stays inside the chelator after decay of the parent radionuclide. In our previous work, we showed that the classical recoil effect is only applicable for decays with a Q value higher than 0.6 MeV (in the atomic mass range around 100). However, Zhernosekov et al. published a result for {sup 140}Nd/{sup 140}Pr (Q = 0.222 MeV) which indicated that > 95% of the daughter ({sup 140}Pr) was lost by a DOTA chelator upon decay of {sup 140}Nd. The authors ascribed this to the ''post-effect''. Their experiment was repeated with the {sup 166}Dy/{sup 166}Ho generator to ascertain whether our calculations were correct. It was found that 72% of the daughter ({sup 166}Ho) was liberated from the DOTA chelator, indicating that the 'post effect' does exist in contrast to our recoil calculations. Upon further investigation, we determined that one should not only consider recoil energy levels but also the mode of decay which was able to explain the partial recoil found for {sup 166}Dy/{sup 166}Ho. It is concluded for the {sup 166}Dy/{sup 166}Ho system that the low recoil energy of the daughter nucleus {sup 166}Ho is not a sufficient reason to rule out release of the nuclide from chelators. On the other hand, we found that the ratio of the {sup 166}Ho that gets released corresponds to the ratio of relaxation of Ho atoms via the Auger process. (orig.)

  7. Concentrations and uncertainties of stratospheric trace species inferred from limb infrared monitor of the stratosphere data. I - Methodology and application to OH and HO2. II - Monthly averaged OH, HO2, H2O2, and HO2NO2

    Science.gov (United States)

    Kaye, J. A.; Jackman, C. H.

    1986-01-01

    Difficulties arise in connection with the verification of multidimensional chemical models of the stratosphere. The present study shows that LIMS data, together with a photochemical equilibrium model, may be used to infer concentrations of a variety of zonally averaged trace Ox, OHx, and NOx species over much of the stratosphere. In the lower stratosphere, where the photochemical equilibrium assumption for HOx species breaks down, inferred concentrations should still be accurate to about a factor of 2 for OH and 2.5 for HO2. The algebraic nature of the considered model makes it possible to see easily to the first order the effect of variation of any model input parameter or its uncertainty on the inferred concontration of the HOx species and their uncertainties.

  8. Labeling of biotin with Dy-166/Ho-166 as a stable in vivo generator system

    International Nuclear Information System (INIS)

    Ferro-Flores, G.; Monroy-Guzman, F.; Jimenez-Varela, R.; Tendilla, J.I.; Arteaga-Murphy, C.; Pedraza-Lopez, M.

    2002-01-01

    Aim: Biotin is a vitamin found in low concentration in blood and tissue. In radioimmunodiagnosis and radioimmunotherapy practice, the pre-targeting avidin-biotin strategy has shown that target-to-nontarget radioactivity ratios can be significantly improved. In addition, the biotin content of cancerous tumors is higher than that of normal tissue and it has been found in the cellular nucleus due to a specific transfer of biotin to histones by human serum biotinidase. Because of its nuclear properties, the 166 Dy/ 166 Ho radionuclide pair can be considered as an in vivo generator system. The aim of this work was to synthesize 166 Dy/ 166 Ho-DTPA-bisBiotin to evaluate its potential as a new radiopharmaceutical for targeted radiotherapy. Material and Methods: Dysprosium-166/Holmium-166 chloride was obtained by neutron irradiation of 50 mg of 99% enriched 164 Dy 2 O 3 in a TRIGA Mark III reactor at a flux in the central thimble of 3.10 13 n. cm -2 s -1 for 20 h. Following irradiation, the target was allowed to decay for 2 days, 100 μL of 12 N chloride acid were added and the mixture stirred for 3 min. To this suspension 1.0 mL of injectable water were added and heated for 2 min at 90 0 C. The biotin used in this investigation was diethylenetriaminepentaacetic-α,ω-bis(biocytinamide)(DTPA-bisBiotin, Sigma). Sterile and apyrogenic V-vial was prepared to contain 16.0 mg (1.52 x 10 -4 mmol) of the DTPA-bisBiotin in 4.0 mL of 0.05 M bicarbonate buffer (pH 8.5), then 50 μL of the radiochloride solution were added to the preparation. TLC aluminum cellulose sheets were used as the stationary phase and a ternary mixture of methanol: water: ammonium hydroxide (20:40:2) as the mobile phase. 166 Dy/ 166 Ho-DTPA-bisBiotin traveled with the solvent front R f 0.9-1.0 and the Dy +3 /Ho +3 species remained at the origin (R f 0.0). HPLC reverse phase was also used to evaluate radiochemical purity. The biological integrity of labeled biotin was achieved evaluating its avidity for avidin

  9. Is the 'Bromine Explosion' generated from the reaction BrO HO2 alone?

    Science.gov (United States)

    Behnke, Wolfgang; Zetzsch, Cornelius

    2010-05-01

    We observed bromine explosions (a fast production of atomic Br and Cl under tropospheric conditions) in various smog chamber experiments in Teflon bags at room temperature at a relative humidity of about 80% in the presence of NaCl/NaBr-aerosol, simulated sunlight and ozone (200 - 400 ppb). Time profiles of ozone and hydrocarbons (HCs: n-butane, 2,2-dimethylbutane, tetramethylbutane and toluene, initially about 2 ppb each) were monitored to determine concentrations and source strengths of OH radicals, atomic Cl and Br and the corresponding time profiles of BrCl and Br2 as their photolytic precursors. The number and size of aerosols are measured as well as their chemical composition (Br-, Cl- and oxalic acid). Full records of raw data from the smog chamber runs are available at www.eurochamp.org for potential users. Chemical box model calculations deliver concentrations of various intermediates, such as aldehydes, HO2 and RO2 radicals and the inorganic halogen compounds ClO, BrO, HOCl and HOBr, where HOBr from O3 + Br- => BrO- + O2 in the aqueous/adsorbed phase induces the following gas-phase/ heterogeneous chain reaction Br + O3 => BrO + O2(1) BrO + HO2 => HOBr + O2(2a) HOBr + (Aerosol) => HOBrad(3) Surface-adsorbed HOBr reacts with Br- or Cl- to produce Br2 or BrCl, both of which are released and photolysed. Formation of Br2 should prevail up to Cl-/Br- -ratios of about 104 (Fickert, S., J.W. Adams, J.N. Crowley, J. Geophys. Res., D104, 23719-23727, 1999). A maximum of this ratio is reached about 30 minutes after the beginning and decreases during the next hours - probably by reaction of Br2 with oxalate and absorption of HBr, formed from the reaction of Br with aldehydes. Parallel to chain reaction (1)-(3) a chain reaction replacing Br by Cl seems possible but can not be realized, since the main sink of atomic Cl is its reaction with hydrocarbons - leading to chain termination - in contrast to atomic Br (ratio of rates: kCl[O3]/kCl[HC] ~ 0.1; kBr[O3]/k

  10. Textbook on X-ray diagnostics. Substantiated by Marianne Zimmer-Brossy. 6. new rev. ed.; Lehrbuch der roentgendiagnostischen Einstelltechnik. Begruendet von Marianne Zimmer-Brossy

    Energy Technology Data Exchange (ETDEWEB)

    Becht, Stefanie [Unfallkrankenhaus Berlin (Germany). Inst. fuer Radiologie; Bittner, Roland C. [Helios Klinikum Emil von Behring, Berlin (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Ohmstede, Anke [Klinikum Oldenburg gGmbH (Germany). MTA-Schule; Pfeiffer, Andreas [Klinikum Stuttgart (Germany). Servicecenter Informationstechnik; Rossdeutscher, Reinhard [Johanniter-Krankenhaus im Flaeming, Treuenbrietzen (Germany). Abt. fuer Roentgendiagnostik

    2008-07-01

    The standard textbook on x-ray diagnostics has been revised by the MTRA team and radiologists: The book covers the following topics: General information: the profession of a radiologist, the x-ray department, radiation protection, quality assurance, basic physics, x-ray imaging, analog and digital image processing, archives, image interpretation. Skeleton diagnostics; Inner organs (thorax organs, neck, abdomen, gastrointestinal tract, colon, gall bladder and biliary tract): Special x-ray diagnostic methods: x-ray diagnostic of the female and male chest, x-ray diagnostics of bone joints (arthrography, and contrast media), x-ray diagnostics of the urinary-genital system, x-ray diagnostics of cavities and syrinx, x-ray diagnostics of arteries (arteriography, angiography), percutaneous transluminal angioplasty, x-ray diagnostics of veins (phlebography), x-ray diagnostics of lymphatic vessels and lymph nodes, x-ray diagnostics of spinal cord (myelography); Specific imaging methods: computerized tomography. [German] Ein erfahrenes Team aus MTRA und Radiologen ueberarbeitete und verbesserte das bewaehrte Standardwerk grundlegend. Detailliert, praezise und ausfuehrlich erlaeutert die 6. Neuauflage technische und physikalische Grundlagen, Strahlenschutz, alle wichtigen Einstellungen (vom Skelettsystem bis hin zur Mammadiagnostik) und aktuelle Leitlinien. Nah an der Praxis sind insbesondere die Hinweise zur Patientenvorbereitung und -lagerung, Qualitaetskriterien und Bildmerkmale sowie viele Tipps und Checklisten. Alle Einstellbilder sowie die Mehrzahl der radiologischen Aufnahmen sind erneuert. Die Kapitel zur digitalen Radiographie und den Grundlagen der MRT sind neu, die Kapitel zu CT-Protokollen und zur interventionellen Radiologie erweitert. Ein ausfuehrliches Glossar rundet das Buch ab. Insgesamt ein wertvolles und unverzichtbares Standardwerk fuer Ausbildung und Beruf. (orig.)

  11. Optical characteristics of BaGa{sub 2}S{sub 4}:Ho{sup 3+} and BaGa{sub 2}Se{sub 4}:Ho{sup 3+} single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Sung-Hyu [Chosun University, Kwangju (Korea, Republic of); Jin, Moon-Seog [Dongshin University, Naju (Korea, Republic of); Kim, Wha-Tek [Chonnam National University, Kwangju (Korea, Republic of)

    2005-11-15

    BaGa{sub 2}S{sub 4}, BaGa{sub 2}S{sub 4}:Ho{sup 3+}, BaGa{sub 2}Se{sub 4}, and BaGa{sub 2}Se{sub 4}:Ho{sup 3+} single crystals were grown by using the chemical transport reaction method. The optical energy gaps of the single crystals were investigated in the temperature region from 11 K to 300 K. The temperature dependence of the optical energy gap was well fitted by the Varshni equation. Two broad emission bands were observed in the photoluminescence spectra of the single crystals. These bands were attributed to donor-acceptor pair recombinations. Sharp emission peaks were observed in the BaGa{sub 2}S{sub 4}:Ho{sup 3+} and the BaGa{sub 2}Se{sub 4}:Ho{sup 3+} single crystals and were assigned to radiation recombination between split Stark levels of Ho{sup 3+}.

  12. Návrh na slaďování pracovního a soukromého života ve vybraném podniku

    OpenAIRE

    Švejdíková, Romana

    2013-01-01

    Diplomová práce se zabývá problematikou slaďování práce a soukromého života ve zvolené organizaci. Detailně popisuje nástroje slaďování práce a soukromého života, srovnává teoretické poznatky se skutečností. Práce identifikuje možnosti a překážky slaďování práce a soukromého života u zaměstnanců zkoumané firmy. Na základě semistrukturovaného rozhovoru a dotazníkového šetření jsou navržena opatření pro optimální slaďování práce a života v organizaci. The diploma thesis deals with the issue ...

  13. Preparation of 166 Dy/166 Ho-Macro aggregates as an In vivo generator system for the treatment of arthrophaties

    International Nuclear Information System (INIS)

    Aldama A, T.K.

    2003-01-01

    The present work reports the obtention of macro aggregates of hydroxides of Dysprosium-166/Holmium-166 ( 166 Dy/ 166 Ho-MH), as a generator system in vivo to be used in the treatment of arthritis rheumatoid. The 166 Dy was obtained by neutron irradiation of 166 DyO 3 (enriched to 98.45%) by 20 h in the TRIGA Mark III Reactor and 50 h of decay, to the oxide of 166 Dy/ 166 Ho formed, it was added HCl 0.12 N to obtain a final volume of 3.5 ml of solution of 166 Dy/ 166 Ho chloride. The solution of 166D yCl 3 solution was obtained with an activity of 3.502 mCi (129 MBq), appropriate for the preparation of the radiopharmaceutical 166 Dy/ 166 Ho-MH. The separation of the 166 Dy from the 166 Ho, was carried out by chromatography in an cation exchange column, gaining an appropriate separation, obtaining a 166 Dy with a radionuclide purity greater than 90%. The 166 Dy/ 166 Ho-MH were prepared by addition to the solution of 166 DyCI 3 NaOH 0.5 N low ultrasonic bath with later centrifugation, decanted and resuspension in saline solution, obtaining a radiopharmaceutical with a generator system 166 Dy/ 166 Ho with particles of size average of 3 μm, in form of 166 Dy / 166 Ho-MH. Under these conditions, it was obtained a radiochemical yield greater than 99%. The microscopic analysis and of filtration showed that the formulation doesn't present particles smaller than to 1 μm, neither greater to 50 μm, which will allow, the quick phagocytosis for the synoviocytes of the synovial membrane, and by consequence, an homogeneous distribution of the radiation dose could exist. The sedimentation velocity for the formulated suspension is of 0.04 cm/min that it will allow the administration of homogeneous activities of the radiopharmaceutical, to the no deposit in the injection devices. The studies of stability in vitro indicate us that inside the articulation, the particles won't probably reduce its size neither their radiochemical purity, for that the flight extra articular will be

  14. Line Identification of Atomic and Ionic Spectra of Holmium in the Near-UV. Part I. Spectrum of Ho i

    Energy Technology Data Exchange (ETDEWEB)

    Al-Labady, N.; Özdalgiç, B. [Graduate School of Engineering and Sciences, Istanbul University, TR-34452 Beyazıt, Istanbul (Turkey); Er, A.; Güzelçimen, F.; Öztürk, I. K.; Başar, Gö. [Faculty of Science, Department of Physics, Istanbul University, TR-34134 Vezneciler, Istanbul (Turkey); Kröger, S. [Hochschule für Technik und Wirtschaft Berlin, Wilhelminenhofstr. 75A, D-12459 Berlin (Germany); Kruzins, A.; Tamanis, M.; Ferber, R., E-mail: ikanat@istanbul.edu.tr [Laser Centre, The University of Latvia, Rainis Boulevard 19, LV-1586 Riga (Latvia)

    2017-02-01

    The Fourier Transform spectra of a Holmium hollow cathode discharge lamp have been investigated in the UV spectral range from 25,000 up to 31,530 cm{sup −1} (317 to 400 nm). Two Ho spectra have been measured with neon and argon as buffer gases. Based on the intensity ratios from these two spectra, a distinction was made between atomic and ionic lines (ionic lines are discussed in an accompanying paper). Using the known Ho i energy levels, 71 lines could be classified as transitions of atomic Ho, 34 of which have not been published previously. Another 32 lines, which could not be classified, are listed in the literature and assigned as atomic Ho. An additional 370 spectral lines have been assigned to atomic Ho based on the signal-to-noise ratio in the two spectra measured under different discharge conditions, namely with buffer gases argon and neon, respectively. These 370 lines have not been previously listed in the literature.

  15. Spectroscopic studies of the energy transfer processes important to obtain holmium laser action in the Er:Tm:Ho:YLF

    International Nuclear Information System (INIS)

    Tarelho, Luiz Vicente Gomes

    1995-01-01

    There are several processes of energy transfer between Er, Tm and Ho ions in YLF crystal that could be evaluated using the Foerster-Dexter method. Energy transfer processes, important to understand Holmium laser action, were studied, specially involving the energy transfer between the first excited states of Er and Tm donors and Ho acceptor. The back-transfer processes were evaluated too in order to minimize the system losses. Another important process to understand Ho laser action in the host is the energy diffusion mechanism between donor ions due to excitation migration processes which take place before the energy transfer to Ho. The proposed model of energy transfer was developed to include the diffusion mechanism between donors in the absence and presence of the acceptors. The energy transfer probability was evaluated including the back-transfer processes besides the diffusion assistance. A laser medium model based on the fundamental spectroscopic parameters was used in order to determine the ideal donor acceptor concentrations in order to maximize the laser action of Ho at 2,1 μm. (author)

  16. Determination of Elevator Shaft Uprightness Applying the Terrestrial Laser Scanning Method / Určovanie Zvislosti Výťahovej Šachty Metódou Terestrického Laserového Skenovania

    Directory of Open Access Journals (Sweden)

    Kovanič Ľudovít

    2013-09-01

    Full Text Available V príspevku sú prezentované výsledky geodetického merania a spracovania údajov na určenie geometrických parametrov výťahovej šachty použitím klasických a tiež moderných prístupov získavania meraných dát. Zámerom je overenie možnosti využitia terestrického laserového skenovania ako vhodnej, efektívnej a detailnej metódy pre zber priestorových údajov.

  17. Magnetic interactions in HoCr{sub 1-x}Fe{sub x}O{sub 3} (x = 0, 0.2) investigated by neutron powder diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xinzhi, E-mail: liuxinzhi1984.cn@163.com [Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413 (China); Hao, Lijie; Ma, Xiaobai [Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413 (China); Wang, Chin-Wei [Neutron Group, National Synchrotron Radiation Research Center, Hsinchu 30077, Taiwan (China); Klose, Frank [Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 (Australia); Department of Physics and Materials Science, The City University of Hong Kong, Hong Kong Special Administrative Region (Hong Kong); Liu, Yuntao, E-mail: ytliu@ciae.ac.cn [Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413 (China); Sun, Kai; Li, Yuqing [Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413 (China); Chen, Dongfeng, E-mail: dongfeng@ciae.ac.cn [Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413 (China)

    2017-07-01

    Highlights: • The temperature dependent magnetism of HoCr{sub 1-x}Fe{sub x}O{sub 3} (x = 0, 0.2) were investigated by neutron diffraction. • Cr{sup 3+} moment follows a mean field theory while Ho{sup 3+} follows a spin 1/2 model. • An magneto-elastic strain was observed accompanying with the ordering of Cr{sup 3+}. - Abstract: The temperature dependent magnetism of Fe-doped rare earth orthochromite HoCr{sub 1-x}Fe{sub x}O{sub 3}(x = 0, 0.2) was investigated by neutron powder diffraction. It is found that the magnetism of Cr(Fe){sup 3+} can be well understood within mean field theory, while the ordering of Ho{sup 3+} was induced by the Cr(Fe){sup 3+} sublattice and can be satisfyingly described by an effective S = 1/2 model. The absences of both the most common G{sub x}F{sub z} configuration of Cr{sup 3+} and the ordering of Ho{sup 3+} caused by Ho-Ho interaction evidence a strong Ho{sup 3+}-Cr{sup 3+} interaction which dominates this system. On the other hand, a remarkable magnetoelastic strain was observed accompanying the Cr(Fe){sup 3+} ordering. An analysis based on the equation of state with a Grüneisen approximation was performed and revealed magnetic origin of this strain.

  18. Geometrical frustration in the ferromagnetic pyrochlore Ho2Ti2O7

    DEFF Research Database (Denmark)

    Harris, M.J.; Bramwell, S.T.; McMorrow, D.F.

    1997-01-01

    We report a detailed study of the pyrochlore Ho2Ti2O7, in which the magnetic ions (Ho3+) are ferromagnetically coupled with J similar to 1 K. We show that the presence of local Ising anisotropy leads to a geometrically frustrated ground state, preventing long-range magnetic order down to at least 0...

  19. Experimental infection of calves, sheep, goats and pigs with HoBi-like viruses by direct inoculation or exposure to persistently infected calves

    Science.gov (United States)

    HoBi-like viruses are an emerging species of pestiviruses associated with respiratory and reproductive disease in cattle and in water buffaloes. Although cattle appear to be the main natural hosts, little is know about the potential for HoBi-like viruses to be transmitted to other livestock. In t...

  20. Synthesis, crystal structure, optical and thermal properties of lanthanide hydrogen-polyphosphates Ln[H(PO3)4] (Ln = Tb, Dy, Ho).

    Science.gov (United States)

    Förg, Katharina; Höppe, Henning A

    2015-11-28

    Lanthanide hydrogen-polyphosphates Ln[H(PO3)4] (Ln = Tb, Dy, Ho) were synthesised as colourless (Ln = Tb, Dy) and light pink (Ln = Ho) crystalline powders by reaction of Tb4O7/Dy2O3/Ho2O3 with H3PO3 at 380 °C. All compounds crystallise isotypically (P2(1)/c (no. 14), Z = 4, a(Tb) = 1368.24(4) pm, b(Tb) = 710.42(2) pm, c(Tb) = 965.79(3) pm, β(Tb) = 101.200(1)°, 3112 data, 160 parameters, wR2 = 0.062, a(Ho) = 1363.34(5) pm, b(Ho) = 709.24(3) pm, c(Ho) = 959.07(4) pm, β(Ho) = 101.055(1)°, 1607 data, 158 parameters, wR2 = 0.058). The crystal structure comprises two different infinite helical chains of corner-sharing phosphate tetrahedra. In-between these chains the lanthanide ions are located, coordinated by seven oxygen atoms belonging to four different polyphosphate chains. Vibrational, UV/Vis and fluorescence spectra of Ln[H(PO3)4] (Ln = Tb, Dy, Ho) as well as Dy[H(PO3)4]:Ln (Ln = Ce, Eu) and the magnetic and thermal behaviour of Tb[H(PO3)4] are reported.

  1. Rasch Validation and Cross-validation of the Health of Nation Outcome Scales (HoNOS) for Monitoring of Psychiatric Disability in Traumatized Refugees in Western Psychiatric Care

    DEFF Research Database (Denmark)

    Palic, Sabina; Kappel, Michelle Lind; Makransky, Guido

    2016-01-01

    group. A revised 10-item HoNOS fit the Rasch model at pre-treatment, and also showed excellent fit within the cross-validation data. Culture, gender, and need for translation did not exert serious bias on the measure’s performance. The results establish good monitoring properties of the 10-item Ho...

  2. The reactions of SO3 with HO2 radical and H2O...HO2 radical complex. Theoretical study on the atmospheric formation of HSO5 and H2SO4.

    Science.gov (United States)

    Gonzalez, Javier; Torrent-Sucarrat, Miquel; Anglada, Josep M

    2010-03-07

    The influence of a single water molecule on the gas-phase reactivity of the HO(2) radical has been investigated by studying the reactions of SO(3) with the HO(2) radical and with the H(2)O...HO(2) radical complex. The naked reaction leads to the formation of the HSO(5) radical, with a computed binding energy of 13.81 kcal mol(-1). The reaction with the H(2)O...HO(2) radical complex can give two different products, namely (a) HSO(5) + H(2)O, which has a binding energy that is computed to be 4.76 kcal mol(-1) more stable than the SO(3) + H(2)O...HO(2) reactants (Delta(E + ZPE) at 0K) and an estimated branching ratio of about 34% at 298K and (b) sulfuric acid and the hydroperoxyl radical, which is computed to be 10.51 kcal mol(-1) below the energy of the reactants (Delta(E + ZPE) at 0K), with an estimated branching ratio of about 66% at 298K. The fact that one of the products is H(2)SO(4) may have relevance in the chemistry of the atmosphere. Interestingly, the water molecule acts as a catalyst, [as it occurs in (a)] or as a reactant [as it occurs in (b)]. For a sake of completeness we have also calculated the anharmonic vibrational frequencies for HO(2), HSO(5), the HSO(5)...H(2)O hydrogen bonded complex, H(2)SO(4), and two H(2)SO(4)...H(2)O complexes, in order to help with the possible experimental identification of some of these species.

  3. Microwave absorption in the singlet paramagnet HoVO4 in high pulsed magnetic fields up to 40 T

    International Nuclear Information System (INIS)

    Goiran, M.; Klingeler, R.; Kazei, Z.A.; Snegirev, V.V.

    2007-01-01

    Microwave absorption of the rare-earth (RE) oxide compound HoVO 4 (tetragonal-zircon structure) is investigated in pulsed magnetic fields up to 40 T in the low-temperature range. For a magnetic field along the tetragonal crystal axis a few resonance absorption lines are observed at the wavelengths 871, 406 and 305 μm corresponding to electron transitions from the ground and low-lying energy levels of the Ho 3+ ion. In addition, broad non-resonance absorption is observed at 871 and 406 μm in fields up to 15 T. The positions and intensities of the observed resonance lines are described quite well within the crystal field formalism with the known crystal field parameters. The effects of the small orthorhombic component of the crystal field, magnetic field misorientation out the symmetry axis and various pair interactions on the absorption spectra in HoVO 4 are analyzed and discussed

  4. Structure, magnetic and superconducting properties of MoSr2HoCu2O8-δ

    International Nuclear Information System (INIS)

    Balchev, N.; Nenkov, K.; Mihova, G.; Kunev, B.; Pirov, J.; Dimitrov, D.A.

    2009-01-01

    Samples with nominal composition MoSr 2 HoCu 2 O 8-δ were synthesized and their magnetic and superconducting (SC) properties were investigated. The obtained samples are Mo-deficient. It was established that the magnetic order is of a long-range type. The coincidence of the experimental value of the Curie constant and the theoretical one of MoSr 2 HoCu 2 O 8-δ shows that the observed magnetic properties of the samples are determined by the highly dominating phase Mo-1212. The two-step resistive SC transition, together with the absence of both diamagnetism and a peak in the specific heat between the two critical temperatures may be associated with the presence of a granular superconductivity. The effect of the Mo-deficiency on the magnetic and SC properties of MoSr 2 HoCu 2 O 8-δ was discussed

  5. Možnosti vstřikovacího systému common-rail

    OpenAIRE

    Smilek, Tomáš

    2008-01-01

    Tomáš Smilek Možnosti vstřikovacího systému common-rail BP, Ústav automobilního a dopravního inženýrství, 2008, str. 23, obr. 18, přílohy 0 Bakalářská práce se zabývá vstřikovacím systémem common-rail. Popisuje historii vývoje stejně jako jednotlivé části systému a jejich funkci. Také stanovuje výhody oproti starým způsobům vstřikování. Tomáš Smilek Possibilities of Common-rail Injection System BT, Institute of Automotive Engineering, 2008, p. 23, fig. 18, appendices 0 This study´s motivat...

  6. Comparative Study of Customer Satisfaction for Four Service Center by Using House of Quality (HoQ)

    International Nuclear Information System (INIS)

    Fazila Said; Mohammad Nasir Saluddin

    2012-01-01

    The comparative study between four service center was constructed from the development of House of Quality (HoQ). HoQ is a simple and attractive service innovation tool which can be used to directly show a comprehensive information which contained the voice of customer (VOC), technical response, technical correlation and matrix relationship. The indirect information is a report on technical and planning part which shows the comparison between four service center. This study revealed that the information from HoQ with further discussion on planning part which can be used to assist management in knowing the overall detail information of service center achievement and recognizes the solution for unsatisfied customer through priority improvement activity to enhance the customer satisfaction in future. (author)

  7. Absence of a spin-signature from a single Ho adatom as probed by spin-sensitive tunneling.

    Science.gov (United States)

    Steinbrecher, M; Sonntag, A; dos Santos Dias, M; Bouhassoune, M; Lounis, S; Wiebe, J; Wiesendanger, R; Khajetoorians, A A

    2016-02-03

    Whether rare-earth materials can be used as single-atom magnetic memory is an ongoing debate in recent literature. Here we show, by inelastic and spin-resolved scanning tunnelling-based methods, that we observe a strong magnetic signal and excitation from Fe atoms adsorbed on Pt(111), but see no signatures of magnetic excitation or spin-based telegraph noise for Ho atoms. Moreover, we observe that the indirect exchange field produced by a single Ho atom is negligible, as sensed by nearby Fe atoms. We demonstrate, using ab initio methods, that this stems from a comparatively weak coupling of the Ho 4f electrons with both tunnelling electrons and substrate-derived itinerant electrons, making both magnetic coupling and detection very difficult when compared to 3d elements. We discuss these results in the context of ongoing disputes and clarify important controversies.

  8. The H+/O ratio of proton translocation linked to the oxidation of succinate by mitochondria. Reply to a commentary.

    Science.gov (United States)

    Lehninger, A L; Reynafarje, B; Hendler, R W; Shrager, R I

    1985-11-18

    Costa, L.E., Reynafarje, B. and Lehninger, A.L. [(1984) J. Biol. Chem. 259, 4802-4811] have reported 'second-generation' measurements of the H+/O ratio approaching 8.0 for vectorial H+ translocation coupled to succinate oxidation by rat liver mitochondria. In a Commentary in this Journal [Krab, K., Soos, J. and Wikström, M. (1984) FEBS Lett. 178, 187-192] it was concluded that the measurements of Costa et al. significantly overestimated the true H+/O stoichiometry. It is shown here that the mathematical simulation on which Krab et al. based this claim is faulty and that data reported by Costa et al. had already excluded the criticism advanced by Krab et al. Also reported are new data, obtained under conditions in which the arguments of Krab et al. are irrelevant, which confirm that the H+/O ratio for succinate oxidation extrapolated to level flow is close to 8.

  9. Vliv různé technologie mletí na vlastnosti Portlandského cementu

    OpenAIRE

    Švéda, Matěj

    2017-01-01

    Tato diplomová práce se zabývá vlivem různých technologií vysokoenergetického mletí na krystalografické vlastnosti hlavních minerálů portlandského cementu a jeho granulometrické vlastnosti. Dále sleduje vliv konvenční a vysokorychlostní technologie mletí na výsledné fyzikálně-mechanické vlastnosti portlandského cementu v závislosti na jeho době odležení. This diploma thesis compares impact of various high-energy grinding technologies on crystallographic and granulometric properties of port...

  10. Evaluation of the performance of a Ho: Sc2SiO5 laser pumped by a Tm:YAP laser

    Science.gov (United States)

    Yang, Xiao-tao; Xie, Wen-qiang; Li, Wen-hui; Li, Xue-min

    2016-05-01

    A continuous-wave 0.5 % Ho3+-doped Ho:Sc2SiO5 (Ho:SSO) laser output at 2112 nm pumped by a Tm:YAP laser is reported. The Ho:SSO bulk crystal was grown by the Czochralski technique. A maximum laser power of 3.72 W was obtained with a slope efficiency of 32.9%, when the transmittance of output mirror was 30%. In this experiment, two output mirrors with different transmittance were also researched. The output spectra of Ho:SSO laser with different output mirrors are also given. The M 2 factor is found to be 1.29. In addition, the absorption and emission spectra are given in this paper.

  11. Evaluation of the performance of a Ho: Sc2SiO5 laser pumped by a Tm:YAP laser

    International Nuclear Information System (INIS)

    Yang, Xiao-tao; Xie, Wen-qiang; Li, Wen-hui; Li, Xue-min

    2016-01-01

    A continuous-wave 0.5 % Ho 3+ -doped Ho:Sc 2 SiO 5 (Ho:SSO) laser output at 2112 nm pumped by a Tm:YAP laser is reported. The Ho:SSO bulk crystal was grown by the Czochralski technique. A maximum laser power of 3.72 W was obtained with a slope efficiency of 32.9%, when the transmittance of output mirror was 30%. In this experiment, two output mirrors with different transmittance were also researched. The output spectra of Ho:SSO laser with different output mirrors are also given. The M 2 factor is found to be 1.29. In addition, the absorption and emission spectra are given in this paper. (paper)

  12. Impact of pulse duration on Ho:YAG laser lithotripsy: fragmentation and dusting performance.

    Science.gov (United States)

    Bader, Markus J; Pongratz, Thomas; Khoder, Wael; Stief, Christian G; Herrmann, Thomas; Nagele, Udo; Sroka, Ronald

    2015-04-01

    In vitro investigations of Ho:YAG laser-induced stone fragmentation were performed to identify potential impacts of different pulse durations on stone fragmentation characteristics. A Ho:YAG laser system (Swiss LaserClast, EMS S.A., Nyon, Switzerland) with selectable long or short pulse mode was tested with regard to its fragmentation and laser hardware compatibility properties. The pulse duration is depending on the specific laser parameters. Fragmentation tests (hand-held, hands-free, single-pulse-induced crater) on artificial BEGO stones were performed under reproducible experimental conditions (fibre sizes: 365 and 200 µm; laser settings: 10 W through combinations of 0.5, 1, 2 J/pulse and 20, 10, 5 Hz, respectively). Differences in fragmentation rates between the two pulse duration regimes were detected with statistical significance for defined settings. Hand-held and motivated Ho:YAG laser-assisted fragmentation of BEGO stones showed no significant difference between short pulse mode and long pulse mode, neither in fragmentation rates nor in number of fragments and fragment sizes. Similarly, the results of the hands-free fragmentation tests (with and without anti-repulsion device) showed no statistical differences between long pulse and short pulse modes. The study showed that fragmentation rates for long and short pulse durations at identical power settings remain at a comparable level. Longer holmium laser pulse duration reduces stone pushback. Therefore, longer laser pulses may result in better clinical outcome of laser lithotripsy and more convenient handling during clinical use without compromising fragmentation effectiveness.

  13. The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.

    Science.gov (United States)

    Pecorella, Shelly R H; Potter, Jennifer V F; Cherry, Anne D; Peacher, Dionne F; Welty-Wolf, Karen E; Moon, Richard E; Piantadosi, Claude A; Suliman, Hagir B

    2015-10-15

    The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here we examined whether CO breathing can be used to produce a coordinated metabolic and vascular response in human skeletal muscle. In 19 healthy subjects, we performed vastus lateralis muscle biopsies and tested one-legged maximal O2 uptake (V̇o2max) before and after breathing air or CO (200 ppm) for 1 h daily for 5 days. In response to CO, there was robust HO-1 induction along with increased mRNA levels for nuclear-encoded mitochondrial transcription factor A (Tfam), cytochrome c, cytochrome oxidase subunit IV (COX IV), and mitochondrial-encoded COX I and NADH dehydrogenase subunit 1 (NDI). CO breathing did not increase V̇o2max (1.96 ± 0.51 pre-CO, 1.87 ± 0.50 post-CO l/min; P = not significant) but did increase muscle citrate synthase, mitochondrial density (139.0 ± 34.9 pre-CO, 219.0 ± 36.2 post-CO; no. of mitochondrial profiles/field), myoglobin content and glucose transporter (GLUT4) protein level and led to GLUT4 localization to the myocyte membrane, all consistent with expansion of the tissue O2 transport system. These responses were attended by increased cluster of differentiation 31 (CD31)-positive muscle capillaries (1.78 ± 0.16 pre-CO, 2.37 ± 0.59 post-CO; capillaries/muscle fiber), implying the enrichment of microvascular O2 reserve. The findings support that induction of the HO-1/CO system by CO not only improves muscle mitochondrial density, but regulates myoglobin content, GLUT4 localization, and capillarity in accordance with current concepts of skeletal muscle plasticity. Copyright © 2015 the American Physiological Society.

  14. Beam delivery system for Ho:YLF and applications in endodontics

    International Nuclear Information System (INIS)

    Bachmann, Luciano

    2000-01-01

    The beam delivery systems, whether using fibers or articulated arms, are very important for the expansion of laser applications into life sciences. This work aims to couple an optical fiber to a home-made Er:Tm:Ho:LiYF 4 laser. For this purpose the beam profile was studied using the beam quality factor M 2 to achieve an homogeneous beam. To determine the M 2 factor, the knife-edge technique was used, relating the laser energy eclipsed by the knife with its transversal position. The resonant cavity was made suitable in order to obtain a stable and homogeneous transversal beam profile, for the optical fiber coupling. It was used a 365 μm diameter core low OH - content fused silica optical fiber, with a proximal SMA-905 connection and a flat distal end. M 2 factors for the Ho:YLF were between 3 and 8, with a non astigmatic beam, although it was observed a divergence asymmetry in the transversal sections. The coupling efficiency was 96%, and in a repeated operation without any adjustment, the new coupling were 82% and 81%. Lasers have being recently used as an adjunct to conventional endodontic preparation to reduce intracanal microbial, preventing reinfection. The knowledge of thermal profile in endodontic procedures is important to determine laser irradiation conditions avoiding periodontal damages. In this sense, the second scope of this work was to use the Ho:YLF system to register the thermal profile in vitro and to compare the results with those obtained with Nd:YAG and Er:YAG commercial lasers. The temperature was recorded in real time through a thermocouple probe at the root apex , resulting in maximum increase of 7 deg C. (author)

  15. Transport properties of RCo_2B_2C with R = Dy, Ho, and Pr single

    Science.gov (United States)

    Duran, Alejandro; Escudero, Roberto

    2002-03-01

    Single crystals of (Dy, Ho, Pr)Co_2B_2C have been grown by a cold copper crucible method. Metallurgical and structural studies indicate that this borocarbide family melts incongruently and crystallizes as a derivative structure of the ThCr_2Si_2. The family accepts rare earth atoms depending on the type of transition metals used to form the compound. For instance with Ni atoms, all lanthanides ranging from the large lanthanum to lutetium ions are reported to form RNi_2B_2C single crystals, so far no single crystals have been obtained when changing Ni by Cobalt. A comparison of the structural parameters of the RCo_2B_2C with the RNiHo, Pr) compounds indicate that the atomic distance between transition metal atoms contracts with the insertion of the Co ion, resulting in an increasing of the c parameter and decreasing volume. Several recent reports published in the current literature related on the physical properties of RCo_2B_2C (R = rare earth metals and Y) have been only performed on polycrystalline samples, they commonly contain small amounts of second phases. High quality single crystals are necessaries in order to better understand the physical properties, such as anisotropy in the transport and in the magnetic properties. In this report we show magnetic susceptibility and resistivity measurements performed in single crystals in the ab-plane and c direction for 2 - 320 K temperature range for the three single crystals of (Dy, Ho, Pr)Co_2B_2C.

  16. Anomalies of magnetoresistance of compounds with atomic clusters RB12 (R = Ho, Er, Tm, Lu)

    International Nuclear Information System (INIS)

    Sluchanko, N. E.; Bogach, A. V.; Glushkov, V. V.; Demishev, S. V.; Samarin, N. A.; Sluchanko, D. N.; Dukhnenko, A. V.; Levchenko, A. V.

    2009-01-01

    The magnetoresistance and magnetization of single-crystal samples of rare-earth dodecaborides RB 12 (R = Ho, Er, Tm, Lu) have been measured at low temperatures (1.8-35 K) in a magnetic field of up to 70 kOe. The effect of positive magnetoresistance that obeys the Kohler's rule Δρ/ρ = f(ρ(0, 300 K)H/ρ(0, T)) is observed for the nonmagnetic metal LuB 12 . In the magnetic dodecaborides HoB 12 , ErB 12 , and TmB 12 , three characteristic regimes of the magnetoresistance behavior have been revealed: the positive magnetoresistance effect similar to the case of LuB 12 is observed at T > 25 K; in the range T N ≤ T ≤ 15 K, the magnetoresistance becomes negative and depends quadratically on the external magnetic field; and, finally, upon the transition to the antiferromagnetic phase (T N ), the positive magnetoresistance is again observed and its amplitude reaches 150% for HoB 12 . It has been shown that the observed anomalies of negative magnetoresistance in the paramagnetic phase can be explained within the Yosida model of conduction electron scattering by localized magnetic moments. The performed analysis confirms the formation of spin-polaron states in the 5d band in the vicinity of rare-earth ions in paramagnetic and magnetically ordered phases of RB 12 and makes it possible to reveal a number of specific features in the transformation of the magnetic structure of the compounds under investigation

  17. Transport and thermodynamic properties of Ho5SixGe4-x

    International Nuclear Information System (INIS)

    Prokleska, J.; Vejpravova, J.; Danis, S.; Sechovsky, V.

    2006-01-01

    We report on the evolution of magnetic phase transitions (MPTs) in the Ho 5 Si x Ge 4-x compounds investigated by means of electrical-resistivity (R) and specific-heat (C p ) measurements with respect to temperature and magnetic field. These materials apparently order antiferromagnetically and undergo two order-order transitions at lower temperatures, which was revealed by appearance and magnetic-field induced evolution of corresponding anomalies in the R(T) and C p (T) curves. The Neel temperature, T N , decreases with increasing x. An applied magnetic field yields reduction of critical temperatures, suppression and smearing of the reported MPTs

  18. Adapting TESLA technology for future cw light sources using HoBiCaT

    Science.gov (United States)

    Kugeler, O.; Neumann, A.; Anders, W.; Knobloch, J.

    2010-07-01

    The HoBiCaT facility has been set up and operated at the Helmholtz-Zentrum-Berlin and BESSY since 2005. Its purpose is testing superconducting cavities in cw mode of operation and it was successfully demonstrated that TESLA pulsed technology can be used for cw mode of operation with only minor changes. Issues that were addressed comprise of elevated dynamic thermal losses in the cavity walls, necessary modifications in the cryogenics and the cavity processing, the optimum choice of operational parameters such as cavity temperature or bandwidth, the characterization of higher order modes in the cavity, and the usability of existing tuners and couplers for cw.

  19. Magnetic Coulomb phase in the spin ice Ho2Ti2O7.

    Science.gov (United States)

    Fennell, T; Deen, P P; Wildes, A R; Schmalzl, K; Prabhakaran, D; Boothroyd, A T; Aldus, R J; McMorrow, D F; Bramwell, S T

    2009-10-16

    Spin-ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice. Their low-temperature magnetic state has been predicted to be a phase that obeys a Gauss' law and supports magnetic monopole excitations: in short, a Coulomb phase. We used polarized neutron scattering to show that the spin-ice material Ho2Ti2O7 exhibits an almost perfect Coulomb phase. Our result proves the existence of such phases in magnetic materials and strongly supports the magnetic monopole theory of spin ice.

  20. Therapeutical radiopharmaceuticals based In vivo generator system [166 Dy] Dy/166 Ho

    International Nuclear Information System (INIS)

    Ferro F, G.; Garcia S, L.; Monroy G, F.; Tendilla, J.I.; Pedraza L, M.; Murphy, C.A. de

    2002-01-01

    At the idea to administer to a patient a molecule containing in it structure a father radionuclide, with a half life enough large which allows to the radiolabelled molecule to take up position specifically in a white tissue and decaying In vivo to the daughter radionuclide with properties potentially therapeutic, it is known as In vivo generator system. In this work the preparation and the preliminary dosimetric valuations of radiopharmaceuticals based In vivo generator system 166 Dy Dy/ 166 Ho for applications in radioimmunotherapy, in the treatment of the rheumatoid arthritis and in the bone marrow ablation (m.o.) for candidates patients to bone marrow transplant are presented. (Author)

  1. Photoabsorption by the 3d shell in Ce, Pr, Ho, and Er: Observations and calculations

    International Nuclear Information System (INIS)

    Sugar, J.; Brewer, W.D.; Kalkowski, G.; Kaindl, G.; Paparazzo, E.

    1985-01-01

    Improved 3d photoabsorption spectra of the series of rare-earth fluorides have been obtained by recording total electron yield and using monochromatized synchrotron radiation. They are compared with predicted spectra resulting from an average-of-configuration calculation of wave functions employing radial integrals adjusted to the observed spectrum in each case; results are presented here for Ce, Pr, Ho, and Er spectra. Improved resolution of the Ce spectrum permitted for the first time a determination of the proper scaling for all of the electrostatic parameters

  2. Laser excited fluorescence spectrum of Ho3+:SrF2 single crystal

    International Nuclear Information System (INIS)

    Lal, Bansi; Ramachandra Rao, D.

    1980-01-01

    The fluorescence spectrum of Ho 3+ : SrF 2 single crystal excited by the various lines of an Ar + laser, is reported. The three fluorescence groups recorded in the region 5300-7700 A, correspond to the transitions from ( 5 F 4 , 5 S 2 ) to 5 I 8 , 5 F 5 to 5 I 8 , 5 F 3 to 5 I 7 and ( 5 F 4 , 5 S 2 ) to 5 I 7 . Marked changes in the total integrated intensity of the various fluorescence groups with the change in the exciting wavelength are observed. (author)

  3. The innovation and tradition of science: centennial of academician Ho Zah-Wei

    International Nuclear Information System (INIS)

    Liu Xiao

    2014-01-01

    This article reviews Mrs. Ho Zah-Wei's academic experiences in several different aspects. She inherited the idea of 'Saving the Nation by Science' from older scholars such as Cai Yuanpei. Receiving advanced scientific education and discipline, she made the important innovation through international communication and collaboration. After returned to China, She took part in the foundation of the Chinese nuclear science, assembled and trained many prominent scientists. To commemorate her centennial, we should not only cherish her scientific innovation and undertaking, but also develop her scientific spirit and tradition. (authors)

  4. 159Ho levels excited by 159 Er EC/β+ decay

    International Nuclear Information System (INIS)

    Kallinnikov, V.G.; Ibraheem, Y.S.; Vaganov, Yu.A.; Stegailov, V.I.; Sereeter, Zh.; Chaloun, P.

    2004-01-01

    Full text: The present study of the EC/β + decay of 159 Er to the levels in 159 Ho was completed at the ISOL complex of YASNAPP-2 at JINR, Dubna. Single γ-ray and γ- γ-coincidence spectra were recorded with HPGe-detectors. Conversion electron spectra were measured by using magnetic spectrometer 'mini-orange' with Si(Li) detector. Results of γ-ray and ICE measurements previously reported by Boutet [1] and in our laboratory [2] have been investigated very accurately. It was shown, that a number of week γ-transitions does not belong to the isotope 159 Er. The special attention was given to high-energy part of a γ-spectrum where in ref. [3] 50 γ -transitions were attributed to the decay of 159 Er with E γ ≥1838.5 keV. We shall point out, that some of them were attributed to this nuclide unreasonably, as their energies E γ exceed the energy of β-decay of 159 Er (2768.5 keV). The most of transitions which have been listed in [3] according to our analysis belong to impurities. In addition to the results [1,2] multipolarities of several γ-transitions with E γ >500 keV were determined, that allowed to establish quantum characteristics of separate levels in 159 Ho. The existence of transition with admixture of E0-component indicates that β-vibrational states in daughter nucleus are excited. We observed this E0-component in the γ- transition (939.5 keV) in the case of 159 Er decay to the levels in 159 Ho. As in the case of 161 Er decay, it was not possible for us to find out three-quasiparticle states in 159 Ho, predicted by superfluid model at excitation energies E γ ≥ 1.5 MeV by observation of the fast au- β- transitions. This work was supported by RFBR (grant No. 03-02-17395)

  5. Sources of HO x and production of ozone in the upper troposphere over the United States

    OpenAIRE

    Jaeglé, L.; Jacob, Daniel James; Brune, W. H.; Tan, D.; Faloona, I. C.; Weinheimer, A. J.; Ridley, B. A.; Campos, T. L.; Sachse, G. W.

    1998-01-01

    The sources of HOx (OH+peroxy radicals) and the associated production of ozone at 8–12 km over the United States are examined by modeling observations of OH, HO2, NO, and other species during the SUCCESS aircraft campaign in April–May 1996. The HOx concentrations measured in SUCCESS are up to a factor of 3 higher than can be calculated from oxidation of water vapor and photolysis of acetone. The highest discrepancy was seen in the outflow of a convective storm. We show that convective injecti...

  6. Phase transition and thermodynamic stability of topological black holes in Hořava-Lifshitz gravity

    Science.gov (United States)

    Ma, Meng-Sen; Zhao, Ren; Liu, Yan-Song

    2017-08-01

    On the basis of horizon thermodynamics, we study the thermodynamic stability and P-V criticality of topological black holes constructed in Hořava-Lifshitz (HL) gravity without the detailed-balance condition (with general ɛ). In the framework of horizon thermodynamics, we do not need the concrete black hole solution (the metric function) and the concrete matter fields. It is shown that the HL black hole for k=0 is always thermodynamically stable. For k=1 , the thermodynamic behaviors and P-V criticality of the HL black hole are similar to those of RN-AdS black hole for some \

  7. Právní aspekty jeruzalémského procesu s Adolfem Eichmannem

    OpenAIRE

    Kohout, David

    2009-01-01

    -89- 6 English Résumé, Key Words Právní aspekty jeruzalémského procesu s Adolfem Eichmannem Legal Aspects of the Jerusalem Trial of Adolf Eichmann Résumé In this diploma thesis I tried to provide a more or less complete overview of legal aspects of the trial of Adolf Eichmann and to point out some of its extra-legal consequences too. This trial took place in Jerusalem and together with the pre-trial proceedings it spanned more than two years. On the course of those two years (and predominan...

  8. Redakční systém sportovního klubu

    OpenAIRE

    Gvizd, Peter

    2015-01-01

    GVIZD, P., Redakční systém sportovního klubu. Brno, 2015. The aim of this Bachelor thesis is to create a content management systems's de-sign for the sport club Jednota Sokol Chocholná -- Velčice. The design is created on the basis of the club analysis and the identification of the key properties, which should be met by the content management system. Other properties of the content management system are deduced from the club requirements. The implementation was realized by standard technologi...

  9. Infra-red laser source using Tm:Ho optical fibre for potential sensor applications

    International Nuclear Information System (INIS)

    Chen, S Y; Yeo, T L; Leighton, J; Sun, T; Grattan, K T V; Lade, R; Powell, B; Foster-Turner, G; Osborne, M

    2007-01-01

    In this work, a 1600nm Er fibre laser, which demonstrates a high pumping efficiency, has been used to pump an efficient all-fibre Tm:Ho laser system using a 0.3 m length of optical fibre. A low threshold of 33 mW and a slope efficiency of 0.6% have been achieved with operation at a wavelength of ∼1870 nm. A cross-comparison has been made with the output of a device pumped by a 785 nm laser diode. The focus of the work is better and more compact sources for gas sensing in the near infra red region of the spectrum

  10. Giant Magnetic Fluctuations at the Critical Endpoint in Insulating HoMnO3

    Science.gov (United States)

    Choi, Y. J.; Lee, N.; Sharma, P. A.; Kim, S. B.; Vajk, O. P.; Lynn, J. W.; Oh, Y. S.; Cheong, S.-W.

    2013-04-01

    Although abundant research has focused recently on the quantum criticality of itinerant magnets, critical phenomena of insulating magnets in the vicinity of critical endpoints (CEP’s) have rarely been revealed. Here we observe an emergent CEP at 2.05 T and 2.2 K with a suppressed thermal conductivity and concomitant strong critical fluctuations evident via a divergent magnetic susceptibility (e.g., χ''(2.05T,2.2K)/χ''(3T,2.2K)≈23,500%, comparable to the critical opalescence in water) in the hexagonal insulating antiferromagnet HoMnO3.

  11. Growth and characterization of Yb:Ho:YAG single crystal fiber

    Science.gov (United States)

    Yang, Yilun; Ye, Linhua; Bao, Renjie; Li, Shanming; Zhang, Peixiong; Xu, Min; Hang, Yin

    2018-06-01

    High quality Yb and Ho co-doped Y3Al5O12 single crystal fibers have been successfully grown by the laser heated pedestal growth method of up to 124 mm in length and 450 μm in diameter for the first time. The results of inductively coupled plasma-atomic emission spectrometry analysis, X-ray diffraction and Raman spectroscopy reveal that the lattice structure and doping concentrations of the SCF are the same as that of the bulk. Scanning electron microscopy microphotographs shows that the fibers only have minor diameter fluctuations within 0.5%.

  12. HO-1 gene overexpression enhances the beneficial effects of superparamagnetic iron oxide labeled bone marrow stromal cells transplantation in swine hearts underwent ischemia/reperfusion: an MRI study.

    Science.gov (United States)

    Jiang, Yibo; Chen, Lijuan; Tang, Yaoliang; Ma, Genshan; Shen, Chengxing; Qi, Chunmei; Zhu, Qi; Yao, Yuyu; Liu, Naifeng

    2010-05-01

    To determine the effect of intracoronary transfer of superparamagnetic iron oxide (SPIO) labeled heme oxygenase-1 (HO-1) overexpressed bone marrow stromal cells (BMSCs) in a porcine myocardial ischemia/reperfusion model. Cell apoptosis was assayed and supernatant cytokine concentrations were measured in BMSCs that underwent hypoxia/reoxygen in vitro. Female mini-swines that underwent 1 h LAD occlusion followed by 1 h reperfusion were randomly allocated to receive intracoronary saline (control), 1 x 10(7) SPIO-labeled BMSCs transfected with pcDNA3.1-Lacz plasmid (Lacz-BMSCs), pcDNA3.1-human HO-1 (HO-1-BMSCs), pcDNA3.1-hHO-1 pretreated with a HO inhibitor, tin protoporphyrin (SnPP, n = 10 each). MRI and postmortem histological analysis were made at 1 week or 3 months thereafter. Post hypoxia/reoxygen in vitro, apoptosis was significantly reduced, supernatant VEGF significantly increased while TNF-alpha and IL-6 significantly reduced in HO-1-BMSCs group compared with Lacz-BMSCs group (all p < 0.05). Myocardial expression of VEGF was significantly higher in HO-1-BMSCs than in Lacz-BMSCs group at 1 week post transplantation (all p < 0.05). Signal voids induced by the SPIO were detected in the peri-infarction region in all BMSC groups at 1 week but not at 3 months post transplantation and the extent of the hypointense signal was the highest in HO-1-BMSCs group, and histological analysis showed that signal voids represented cardiac macrophages that engulfed the SPIO-labeled BMSCs. Pretreatment with SnPP significantly attenuated the beneficial effects of HO-1-BMSCs. Transplantation of HO-1-overexpressed BMSCs significantly enhanced the beneficial effects of BMSCs on improving cardiac function in this model.

  13. HO-1 inhibits IL-13-induced goblet cell hyperplasia associated with CLCA1 suppression in normal human bronchial epithelial cells.

    Science.gov (United States)

    Mishina, Kei; Shinkai, Masaharu; Shimokawaji, Tadasuke; Nagashima, Akimichi; Hashimoto, Yusuke; Inoue, Yoriko; Inayama, Yoshiaki; Rubin, Bruce K; Ishigatsubo, Yoshiaki; Kaneko, Takeshi

    2015-12-01

    Mucus hypersecretion and goblet cell hyperplasia are common features that characterize asthma. IL-13 increases mucin (MUC) 5AC, the major component of airway mucus, in airway epithelial cells. According to the literature, IL-13 receptor activation leads to STAT6 activation and consequent induction of chloride channel accessory 1 (CLCA1) gene expression, associated with the induction of MUC5AC. Heme oxygenase-1 (HO-1) is an enzyme that catalyzes oxidation of heme to biliverdin, and has anti-inflammatory and anti-oxidant properties. We examined the effects of HO-1 on mucin production and goblet cell hyperplasia induced by IL-13. Moreover, we assessed the cell signaling intermediates that appear to be responsible for mucin production. Normal human bronchial epithelial (NHBE) cells were grown at air liquid interface (ALI) in the presence or absence of IL-13 and hemin, a HO-1 inducer, for 14 days. Protein concentration was analyzed using ELISA, and mRNA expression was examined by real-time PCR. Histochemical analysis was performed using HE staining, andWestern blotting was performed to evaluate signaling transduction pathway. Hemin (4 μM) significantly increased HO-1 protein expression (p b 0.01) and HO-1 mRNA expression (p b 0.001). IL-13 significantly increased goblet cells, MUC5AC protein secretion (p b 0.01) and MUC5AC mRNA (p b 0.001), and these were decreased by hemin by way of HO-1. Tin protoporphyrin (SnPP)-IX, a HO-1 inhibitor, blocked the effect of hemin restoring MUC5AC protein secretion (p b 0.05) and goblet cell hyperplasia. Hemin decreased the expression of CLCA1 mRNA (p b 0.05) and it was reversed by SnPP-IX, but could not suppress IL-13-induced phosphorylation of STAT6 or SAM pointed domain-containing ETS transcription factor (SPDEF) and Forkhead box A2 (FOXA2) mRNA expression. In summary, HO-1 overexpression suppressed IL-13-induced goblet cell hyperplasia and MUC5AC production, and involvement of CLCA1 in the mechanism was suggested.

  14. Magnetic and Mössbauer studies of amorphous Fe 72- xY xHo 8B 20 alloys

    Science.gov (United States)

    Krishnan, R.; Driouch, L.; Lassri, H.; Dumond, Y.; Ajan, Antony; Shringi, S. N.; Prasad, Shiva

    1996-11-01

    We have carried out magnetic and Mössbauer studies of amorphous Fe 72- xY xHo 8B 20 alloys. The Fe moment decreases with the addition of Y and a magnetic compensation occurs at 4 K for x = 16. The temperature and field dependences of the magnetization have been interpreted using the mean field theory and Chudnovsky's model, respectively. These analyses yield some interesting parameters such as the random anisotropy, the exchange interactions JFe-Fe, JFe-Ho, etc. The Mössbauer studies show that the average hyperfine field decreases linearly with the addition of Y, in accordance with the decrease in the Fe moment.

  15. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Yuanxue; Xu, Xiaojun; Chang, Sai; Wang, Yunjie; Xu, Yazhou; Ran, Siqi [Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009 (China); Huang, Zhangjian [Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009 (China); Li, Ping [Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009 (China); Li, Jia [National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Road, Shanghai 201203 (China); Zhang, Luyong [Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009 (China); Saavedra, Juan M. [Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057 (United States); Liao, Hong, E-mail: liaohong56@hotmail.com [Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009 (China); Pang, Tao, E-mail: tpang@cpu.edu.cn [Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009 (China); Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057 (United States)

    2015-12-01

    The natural product totarol, a phenolic diterpenoid and a major constituent isolated from the sap of Podocarpus totara, has been reported to have a potent antimicrobial activity. In this study, we determined whether totarol possessed an additional neuroprotective activity in vitro and in vivo. We found that totarol prevented glutamate- and oxygen and glucose deprivation-induced neuronal death in primary rat cerebellar granule neuronal cells and cerebral cortical neurons. Totarol increased Akt and GSK-3β phosphorylation, Nrf2 and heme oxygenase-1 (HO-1) protein expressions and suppressed oxidative stress by increasing GSH and SOD activities. The PI3K/Akt inhibitor LY294002 prevented totarol neuroprotective effect by suppressing the totarol-induced changes in HO-1 expression and the activities of GSH and SOD. The HO-1 inhibitor ZnPPIX also prevented totarol-increased GSH and SOD activities. In a model of acute cerebral ischemic injury in Sprague–Dawley rats, produced by occlusion of the middle cerebral artery for 2 h followed by 22 h or 46 h of reperfusion, totarol significantly reduced infarct volume and improved the neurological deficit. In this model, totarol increased HO-1 expression and the activities of GSH and SOD. These observations suggest that totarol may be a novel activator of the Akt/HO-1 pathway protecting against ischemic stroke through reduction of oxidative stress. - Graphical abstract: It is unknown whether the natural product totarol has neuroprotective effects in vitro and in vivo. This study underscores that totarol prevents neuronal injury in vitro, not only by activating PI3K/Akt pathway, but also via induction of Nrf2, HO-1, GSH and SOD expressions. Totarol also ameliorated acute cerebral ischemic injury in a rat ischemic stroke model. The findings highlight that totarol may be exploited for protecting against ischemic stroke through Akt/HO-1 pathway. - Highlights: • Totarol protects glutamate- and OGD-induced neuronal injury in vitro.

  16. Marketingový plán fitness centra Expreska Jiřího z Poděbrad

    OpenAIRE

    Štěchová, Kristýna

    2016-01-01

    Title: The marketing plan of fitness center Expreska Jiřího z Poděbrad. Objectives: The main aim of the dimploma thesis is to construct a marketing plan for fitness center Expreska Jiřího z Poděbrad for the year 2017. The proposed marketing strategy, including the implementation plan will be directed to achieve marketing and business goals of the organization. Methods: For analysis of the microenvironment is used Porter matrix. Analysis of macroenvironment is done with the help of PEST analys...

  17. Modeling Photodetachment from HO2- Using the pd Case of the Generalized Mixed Character Molecular Orbital Model

    Science.gov (United States)

    Blackstone, Christopher C.; Sanov, Andrei

    2016-06-01

    Using the generalized model for photodetachment of electrons from mixed-character molecular orbitals, we gain insight into the nature of the HOMO of HO2- by treating it as a coherent superpostion of one p- and one d-type atomic orbital. Fitting the pd model function to the ab initio calculated HOMO of HO2- yields a fractional d-character, γp, of 0.979. The modeled curve of the anisotropy parameter, β, as a function of electron kinetic energy for a pd-type mixed character orbital is matched to the experimental data.

  18. Nanosecond Tm:Y2O3 ceramic laser passively Q-switched by a Ho:LuAG ceramic

    Science.gov (United States)

    Wang, Hui; Huang, Haitao; Wang, Shiqiang; Shen, Deyuan

    2018-02-01

    A passively Q-switched 2.05-μm Tm:Y2O3 ceramic laser, employing Ho:LuAG ceramic as a saturable absorber, was demonstrated for the first time. Under the absorbed pump power of 20.5 W, a maximum output power of 497 mW was obtained. Pulses with a minimum pulse width of 642 ns under the repetition rate of 33 kHz were achieved. Our works validate that Ho-doped materials have good potential for passive Q-switching of Tm-doped lasers at 2-μm wavelength region.

  19. Antiperovskite nitridophosphate oxide Ho{sub 3}[PN{sub 4}]O by high-pressure metathesis

    Energy Technology Data Exchange (ETDEWEB)

    Kloss, Simon D.; Weidmann, Niels; Schnick, Wolfgang [Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich (Germany)

    2017-04-03

    Rare-earth nitridophosphates are a recently discovered class of materials, which are accessible by high-pressure metathesis. Antiperovskite-type Ho{sub 3}[PN{sub 4}]O was synthesized from HoF{sub 3}, LiPN{sub 2}, Li{sub 3}N, and Li{sub 2}O at 5 GPa and ca. 1025 C by this method and the multianvil technique. Ho{sub 3}[PN{sub 4}]O contains rarely observed isolated PN{sub 4} tetrahedra and can be derived by the hierarchical substitution of the ABX{sub 3} perovskite, in which Ho occupies the X positions, O occupies the B position, and the PN{sub 4} tetrahedra occupy the A position. The structure was refined on the basis of powder diffraction data [I4/mcm, a = 6.36112(3), c = 10.5571(1) Aa, Z = 4, R{sub wp} = 0.04, R{sub Bragg} = 0.01, χ{sup 2} = 2.275] starting from the structural model of isotypic Gd{sub 3}[SiN{sub 3}O]O. To characterize Ho{sub 3}[PN{sub 4}]O, elemental analyses were performed through energy-dispersive X-ray spectroscopy (EDX) and inductively coupled plasma optical emission spectroscopy (ICP-OES). Ho{sub 3}[PN{sub 4}]O is paramagnetic down to low temperatures with μ{sub eff} = 10.43(1) μ{sub B} and a Curie temperature (Θ) of 0.11(4) K. It shows the optical characteristics of Ho{sup 3+} ions and vibrations corresponding to isolated PN{sub 4} tetrahedra. On the basis of DFT calculations [generalized gradient approximation (GGA)], Ho{sub 3}[PN{sub 4}]O has an indirect band gap of 1.87 eV. We demonstrate the versatility of high-pressure metathesis by attaining the low end of the P/N atomic ratio κ = 1/4. This confirms the previous assumption that rare-earth nitridophosphates with κ = 1/2 to 1/4 are feasible by this method. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction

    International Nuclear Information System (INIS)

    Gao, Yuanxue; Xu, Xiaojun; Chang, Sai; Wang, Yunjie; Xu, Yazhou; Ran, Siqi; Huang, Zhangjian; Li, Ping; Li, Jia; Zhang, Luyong; Saavedra, Juan M.; Liao, Hong; Pang, Tao

    2015-01-01

    The natural product totarol, a phenolic diterpenoid and a major constituent isolated from the sap of Podocarpus totara, has been reported to have a potent antimicrobial activity. In this study, we determined whether totarol possessed an additional neuroprotective activity in vitro and in vivo. We found that totarol prevented glutamate- and oxygen and glucose deprivation-induced neuronal death in primary rat cerebellar granule neuronal cells and cerebral cortical neurons. Totarol increased Akt and GSK-3β phosphorylation, Nrf2 and heme oxygenase-1 (HO-1) protein expressions and suppressed oxidative stress by increasing GSH and SOD activities. The PI3K/Akt inhibitor LY294002 prevented totarol neuroprotective effect by suppressing the totarol-induced changes in HO-1 expression and the activities of GSH and SOD. The HO-1 inhibitor ZnPPIX also prevented totarol-increased GSH and SOD activities. In a model of acute cerebral ischemic injury in Sprague–Dawley rats, produced by occlusion of the middle cerebral artery for 2 h followed by 22 h or 46 h of reperfusion, totarol significantly reduced infarct volume and improved the neurological deficit. In this model, totarol increased HO-1 expression and the activities of GSH and SOD. These observations suggest that totarol may be a novel activator of the Akt/HO-1 pathway protecting against ischemic stroke through reduction of oxidative stress. - Graphical abstract: It is unknown whether the natural product totarol has neuroprotective effects in vitro and in vivo. This study underscores that totarol prevents neuronal injury in vitro, not only by activating PI3K/Akt pathway, but also via induction of Nrf2, HO-1, GSH and SOD expressions. Totarol also ameliorated acute cerebral ischemic injury in a rat ischemic stroke model. The findings highlight that totarol may be exploited for protecting against ischemic stroke through Akt/HO-1 pathway. - Highlights: • Totarol protects glutamate- and OGD-induced neuronal injury in vitro.

  1. Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes

    International Nuclear Information System (INIS)

    Chien, Peter Tzu-Yu; Lin, Chih-Chung; Hsiao, Li-Der; Yang, Chuen-Mao

    2015-01-01

    Carbon monoxide (CO) is one of the cytoprotective byproducts of heme oxygenase (HO)-1 and exerts anti-inflammatory action in various models. However, the detailed mechanisms underlying CO-induced HO-1 expression in primary human cardiomyocytes remain largely unidentified. We used primary left ventricle myocytes as a model and applied CO releasing molecule (CORM)-2 to investigate the relationship of CO and HO-1 expression. We herein used Western blot, real-time PCR, promoter activity and EIA to investigate the role of HO-1 expression protecting against thrombin-mediated responses. We found that thrombin-induced COX-2 expression, PGE 2 release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. CORM-2-induced HO-1 protein expression, mRNA and promoter was attenuated by pretreatment with the inhibitors of Pyk2 (PF431396), PDGFR (AG1296), PI3K (LY294002), Akt (SH-5), p38 (SB202530), JNK1/2 (SP600125), FoxO1 (AS1842856) and Sp1 (mithramycin A). The involvement of these signaling components was further confirmed by transfection with respective siRNAs, consistent with those of pharmacological inhibitors. These results suggested that CORM-2-induced HO-1 expression is mediated through a Pyk2/PDGFR/PI3K/Akt/FoxO1/Sp1-dependent manner and exerts a cytoprotective effect in human cardiomyocytes. - Graphical abstract: In summary, CORM-2 treatment induces Pyk2 transactivated PDGFR, which induces PI3K/Akt/MAPK activation, and then recruits Sp1/Foxo1 transcriptional factors to regulate HO-1 gene expression in primary human cardiomyocytes. - Highlights: • CORM-2 induces HO-1 expression. • Pyk2-dependent PDGFR activates PI3K/Akt/MAPK pathway in CORM-2-induced HO-1

  2. Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes

    Energy Technology Data Exchange (ETDEWEB)

    Chien, Peter Tzu-Yu [Department of Physiology and Pharmacology and Health Ageing Research Center, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Lin, Chih-Chung; Hsiao, Li-Der [Department of Anesthetics, Chang Gung Memorial Hospital at Lin-Kou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Yang, Chuen-Mao, E-mail: chuenmao@mail.cgu.edu.tw [Department of Physiology and Pharmacology and Health Ageing Research Center, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan (China)

    2015-12-01

    Carbon monoxide (CO) is one of the cytoprotective byproducts of heme oxygenase (HO)-1 and exerts anti-inflammatory action in various models. However, the detailed mechanisms underlying CO-induced HO-1 expression in primary human cardiomyocytes remain largely unidentified. We used primary left ventricle myocytes as a model and applied CO releasing molecule (CORM)-2 to investigate the relationship of CO and HO-1 expression. We herein used Western blot, real-time PCR, promoter activity and EIA to investigate the role of HO-1 expression protecting against thrombin-mediated responses. We found that thrombin-induced COX-2 expression, PGE{sub 2} release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. CORM-2-induced HO-1 protein expression, mRNA and promoter was attenuated by pretreatment with the inhibitors of Pyk2 (PF431396), PDGFR (AG1296), PI3K (LY294002), Akt (SH-5), p38 (SB202530), JNK1/2 (SP600125), FoxO1 (AS1842856) and Sp1 (mithramycin A). The involvement of these signaling components was further confirmed by transfection with respective siRNAs, consistent with those of pharmacological inhibitors. These results suggested that CORM-2-induced HO-1 expression is mediated through a Pyk2/PDGFR/PI3K/Akt/FoxO1/Sp1-dependent manner and exerts a cytoprotective effect in human cardiomyocytes. - Graphical abstract: In summary, CORM-2 treatment induces Pyk2 transactivated PDGFR, which induces PI3K/Akt/MAPK activation, and then recruits Sp1/Foxo1 transcriptional factors to regulate HO-1 gene expression in primary human cardiomyocytes. - Highlights: • CORM-2 induces HO-1 expression. • Pyk2-dependent PDGFR activates PI3K/Akt/MAPK pathway in CORM-2-induced HO

  3. Hořava-Lifshitz gravity from dynamical Newton-Cartan geometry

    International Nuclear Information System (INIS)

    Hartong, Jelle; Obers, Niels A.

    2015-01-01

    Recently it has been established that torsional Newton-Cartan (TNC) geometry is the appropriate geometrical framework to which non-relativistic field theories couple. We show that when these geometries are made dynamical they give rise to Hořava-Lifshitz (HL) gravity. Projectable HL gravity corresponds to dynamical Newton-Cartan (NC) geometry without torsion and non-projectable HL gravity corresponds to dynamical NC geometry with twistless torsion (hypersurface orthogonal foliation). We build a precise dictionary relating all fields (including the scalar khronon), their transformations and other properties in both HL gravity and dynamical TNC geometry. We use TNC invariance to construct the effective action for dynamical twistless torsional Newton-Cartan geometries in 2+1 dimensions for dynamical exponent 1Hořava and Melby-Thompson as coming from the Bargmann extension of the local Galilean algebra that acts on the tangent space to TNC geometries. We argue that TNC geometry, which is manifestly diffeomorphism covariant, is a natural geometrical framework underlying HL gravity and discuss some of its implications.

  4. Magnetic properties and magnetocaloric effect of HoCo3B2 compound

    Directory of Open Access Journals (Sweden)

    X. Q. Zheng

    2018-05-01

    Full Text Available A sample of HoCo3B2 compound was synthesized, and the magnetic and MCE properties were investigated. Compound shows a change corresponding to R-R (R = rare earth sublattice magnetic order transition and the transition temperature is determined to be 11.8 K (TC. The characteristic of Arrott plots with positive slope around TC was observed, indicating a second-order phase transition. Based on isothermal magnetization data, together with Maxwell’s relationship, the magnetic entropy change (-ΔSM was calculated. The maximum -ΔSM reaches 7.8, 12.7 and 14.4 J/kg K for field range of 0-2 T, 0-5 T and 0-7 T, respectively. Accordingly, the value of RC (refrigerant capacity is 99, 289 and 432 J/kg for above field ranges. The large MCE of HoCo3B2 compound indicates its potential application for magnetic refrigeration in low temperature range.

  5. Středisko volného času Kostka

    OpenAIRE

    Křenková, Romana

    2017-01-01

    Tématem diplomové práce je novostavba školního zařízení Střediska volného času Kostka. SVČ je samostatně stojící objekt na mírně svažitém pozemku, se dvěma nadzemními podlažími. Objekt není podsklepen. SVČ se nachází vedle mateřské školy a základní školy. Dispozičně zahrnuje objekt 11 učeben a je navržen pro 163 dětí. Obvodové, vnitřní nosné i nenosné stěny jsou navrženy z cihelných bloků. Stropy jsou tvořeny pomocí předpjatých stropních panelů. Objekt je zastřešen jednoplášťovou plochou stře...

  6. Laboratorní měření předpjatého zdiva

    OpenAIRE

    Stará, Marie; Čajka, Radim; Matečková, Pavlína; Janulíková, Martina

    2012-01-01

    Předpínání zdiva je jednou z nejpoužívanějších a současně nejúčinějších metod sanace u staticky porušených objektů. Na stavební fakultě bylo vyrobeno laboratorní zařízení právě pro bližší zkoumání chování předpínaného zdiva. A to konkrétně pro měření deformací zděného rohu především v okolí kotevních desek, které slouží pro přenos předpínacích sil do zdiva. Měření bylo provedeno pro dvě hodnoty předpínacích sil. Předpětí bylo instalováno v obou směrech. Dále je zde okrajově poj...

  7. Interplay between magnetism and superconductivity in HoNi2B2C revisited

    Science.gov (United States)

    Alleno, E.; Singh, S.; Dhar, S. K.; André, G.

    2010-04-01

    In this work the magnetic and superconducting properties of HoNi2B2C were investigated by using powder neutron diffraction and the specific heat and upper critical field (Hc2) measurements as a function of temperature. Below T=8 K, three distinct anomalies at the temperatures TN=5.2 K, TH1=5.6 K and TM=6.0 K were observed in the specific heat of HoNi2B2C, as reported in the literature. Our neutron data confirm the transitions to the Néel structure (qN=c*) at TN and to the modulated structure (qM=0.586a*) at TM. The peak at TH1=5.7 K in the specific heat data, whose exact nature was not known hitherto, is now attributed to the onset of a qH1=0.905c* magnetic helical structure as seen in our neutron data. Comparison between the thermal evolution of the magnetic structures and the temperature dependence of the upper critical field confirms that the first Hc2(T) depression at 6.1 K arises from the qM=0.586a* modulated magnetic structure. The second depression in Hc2(T) below 5.7 K can be ascribed to the qH1=0.905c* magnetic helical structure.

  8. Činnost realitního makléře v praxi

    OpenAIRE

    Kiš, Miroslav

    2011-01-01

    Po roce 1989 se uvolnil trh s nemovitostmi tím se umožnilo nástupu novému podnikatelskému odvětví a tím je zprostředkování prodeje a služeb při prodeji, nákupu, či pronájmu nemovitosti, které zprostředkovává realitní makléř. Má diplomová práce s názvem, Činnost realitního makléře v praxi“ má za úkol zhodnotit činnost realitního makléře v terénu, systémově uspořádat jeho činnost a tyty činnosti pak vyhodnotit na časovou a ekonomickou náročnost. Svoji práci jsem rozdělil na dvě části. Teoretick...

  9. Einstein’s quadrupole formula from the kinetic-conformal Hořava theory

    Science.gov (United States)

    Bellorín, Jorge; Restuccia, Alvaro

    We analyze the radiative and nonradiative linearized variables in a gravity theory within the family of the nonprojectable Hořava theories, the Hořava theory at the kinetic-conformal point. There is no extra mode in this formulation, the theory shares the same number of degrees of freedom with general relativity. The large-distance effective action, which is the one we consider, can be given in a generally-covariant form under asymptotically flat boundary conditions, the Einstein-aether theory under the condition of hypersurface orthogonality on the aether vector. In the linearized theory, we find that only the transverse-traceless tensorial modes obey a sourced wave equation, as in general relativity. The rest of variables are nonradiative. The result is gauge-independent at the level of the linearized theory. For the case of a weak source, we find that the leading mode in the far zone is exactly Einstein’s quadrupole formula of general relativity, if some coupling constants are properly identified. There are no monopoles nor dipoles in this formulation, in distinction to the nonprojectable Horava theory outside the kinetic-conformal point. We also discuss some constraints on the theory arising from the observational bounds on Lorentz-violating theories.

  10. Solid Waste Management in Ho Chi Minh City, Vietnam: Moving towards a Circular Economy?

    Directory of Open Access Journals (Sweden)

    Petra Schneider

    2017-02-01

    Full Text Available The paper presents the current situation of the waste management system of the megacity Ho Chi Minh in Vietnam, and the options for waste and land recycling in a low income country. Generally, there is a large potential for circular economy in the city as the main proportion of the waste flows are recyclables. Due to the missing selective collection system, this potential is not used in the full extend yet, even if the collection of the entire waste volumes is envisaged in the National Waste Management Strategy by 2025. The waste stocks are the landfill locations in the region of Ho Chi Minh City (HCMC, two of them being in operation and two of them already being closed. A special focus is given to the landfill Gò Cát, which was subject to an option analysis in terms of waste and land recycling options. The results indicate that there are several reuse options: the use of the landfill material in a waste-to-energy process after landfill mining, the reuse of the re-gained land in case of landfill mining, the reuse of the capped landfill for energy crop cultivation, and the gasification in a biogas plant in case of a remaining landfill.

  11. Diagnostický terminál spalovacího motoru na Pocket PC

    OpenAIRE

    Kubiš, Ján

    2008-01-01

    Moja bakalárska práca, v ktorej som mal vytvoriť programový systém pracujúci pod operačním systémom Windows CE 2003, sa zaoberá príjmaním a spracovaním dat, ktoré posiela riadiaca jednotka osmivalcového zážehového motoru Tatra T613/4i. Program je schopný príjmať jednotlivé tabuľky, ktoré riadiaca jednotka vysiela. Veličiny jednotlivých tabuliek je možné zobrazovať vo forme textových a číselných dat. Ďalej systém tiež vie zobrazovať chybné hlásenia, ktoré je riadiaca jednotka schopná posielať....

  12. Adaptation to Sea Level Rise: A Multidisciplinary Analysis for Ho Chi Minh City, Vietnam

    Science.gov (United States)

    Scussolini, Paolo; Tran, Thi Van Thu; Koks, Elco; Diaz-Loaiza, Andres; Ho, Phi Long; Lasage, Ralph

    2017-12-01

    One of the most critical impacts of sea level rise is that flooding suffered by ever larger settlements in tropical deltas will increase. Here we look at Ho Chi Minh City, Vietnam, and quantify the threats that coastal floods pose to safety and to the economy. For this, we produce flood maps through hydrodynamic modeling and, by combining these with data sets of exposure and vulnerability, we estimate two indicators of risk: the damage to assets and the number of potential casualties. We simulate current and future (2050 and 2100) flood risk using IPCC scenarios of sea level rise and socioeconomic change. We find that annual damage may grow by more than 1 order of magnitude, and potential casualties may grow 5-20-fold until the end of the century, in the absence of adaptation. Impacts depend strongly on the climate and socioeconomic scenarios considered. Next, we simulate the implementation of adaptation measures and calculate their effectiveness in reducing impacts. We find that a ring dike would protect the inner city but increase risk in more rural districts, whereas elevating areas at risk and dryproofing buildings will reduce impacts to the city as a whole. Most measures perform well from an economic standpoint. Combinations of measures seem to be the optimal solution and may address potential equity conflicts. Based on our results, we design possible adaptation pathways for Ho Chi Minh City for the coming decades; these can inform policy-making and strategic thinking.

  13. Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Ji Yeon Seo

    2018-01-01

    Full Text Available As soy-derived glyceollins are known to induce antioxidant enzymes in various types of cells and tissues, we hypothesized that the compounds could protect neurons from damage due to reactive oxygen species (ROS. In order to examine the neuroprotective effect of glyceollins, primary cortical neurons collected from mice and mouse hippocampal HT22 cells were challenged with glutamate. Glyceollins attenuated glutamate-induced cytotoxicity in primary cortical neuron isolated from mice carrying wild-type nuclear factor (erythroid-derived 2-like 2 (Nrf2, but the compounds were ineffective in those isolated from Nrf2 knockout mice, suggesting the involvement of the Nrf2 signaling pathway in glyceollin-mediated neuroprotection. Furthermore, the inhibition of heme oxygenase-1 (HO-1, a major downstream enzyme of Nrf2, abolished the suppressive effect of glyceollins against glutamate-induced ROS production and cytotoxicity, confirming that activation of HO-1 by glyceollins is responsible for the neuroprotection. To examine whether glyceollins also improve cognitive ability, mice pretreated with glyceollins were challenged with scopolamine and subjected to behavioral tests. Glyceollins attenuated scopolamine-induced cognitive impairment of mice, but failed to enhance memory in Nrf2 knockout mice, suggesting that the memory-enhancing effect is also mediated by the Nrf2 signaling pathway. Overall, glyceollins showed neuroprotection against glutamate-induced damage, and attenuated scopolamine-induced memory deficits in an Nrf2-dependent manner.

  14. Phase composition of iron-rich R-Fe-Si (R=Dy, Ho, Er) alloys

    International Nuclear Information System (INIS)

    Ivanova, G.V.; Makarova, G.M.; Shcherbakova, E.V.; Belozerov, E.V.

    2005-01-01

    Phase composition is studied in iron-rich alloys of R-Fe-Si (R=Dy, Ho, Er). In the as-cast state R 2 (Fe, Si) 17 of type Th 2 Ni 17 and R(Fe, Si) 12 compounds are observed; in the alloys of rated composition of R(Fe 0.85 Si 0.15 ) 8.5 (R=Dy, Er) a compound R 2 (Fe, Si) 17 of Th 2 Zn 17 -type is revealed as well. The annealing at 1273 K results in formation of Dy 3 (Fe, Si) 29 and also the compounds with the presumed composition of Dy 4 (Fe, Si) 41 and Ho 4 (Fe, Si) 41 . As this takes place the alloys contain a transition structure as well that represents a set of small-sized areas with various type short-range order in mutual displacement of Fe-Fe(Si) dumpbell chains. The process of phase formation at 1273 K is faced with difficulties. Even the annealing for 1000 h does not result in the state of equilibrium [ru

  15. Magnetic properties and magnetocaloric effect of HoCo3B2 compound

    Science.gov (United States)

    Zheng, X. Q.; Xu, J. W.; Zhang, H.; Zhang, J. Y.; Wang, S. G.; Zhang, Y.; Xu, Z. Y.; Wang, L. C.; Shen, B. G.

    2018-05-01

    A sample of HoCo3B2 compound was synthesized, and the magnetic and MCE properties were investigated. Compound shows a change corresponding to R-R (R = rare earth) sublattice magnetic order transition and the transition temperature is determined to be 11.8 K (TC). The characteristic of Arrott plots with positive slope around TC was observed, indicating a second-order phase transition. Based on isothermal magnetization data, together with Maxwell's relationship, the magnetic entropy change (-ΔSM) was calculated. The maximum -ΔSM reaches 7.8, 12.7 and 14.4 J/kg K for field range of 0-2 T, 0-5 T and 0-7 T, respectively. Accordingly, the value of RC (refrigerant capacity) is 99, 289 and 432 J/kg for above field ranges. The large MCE of HoCo3B2 compound indicates its potential application for magnetic refrigeration in low temperature range.

  16. Hořava-Lifshitz gravity from dynamical Newton-Cartan geometry

    Energy Technology Data Exchange (ETDEWEB)

    Hartong, Jelle [Physique Théorique et Mathématique and International Solvay Institutes, Université Libre de Bruxelles,C.P. 231, 1050 Brussels (Belgium); Obers, Niels A. [The Niels Bohr Institute, Copenhagen University,Blegdamsvej 17, DK-2100 Copenhagen Ø (Denmark)

    2015-07-29

    Recently it has been established that torsional Newton-Cartan (TNC) geometry is the appropriate geometrical framework to which non-relativistic field theories couple. We show that when these geometries are made dynamical they give rise to Hořava-Lifshitz (HL) gravity. Projectable HL gravity corresponds to dynamical Newton-Cartan (NC) geometry without torsion and non-projectable HL gravity corresponds to dynamical NC geometry with twistless torsion (hypersurface orthogonal foliation). We build a precise dictionary relating all fields (including the scalar khronon), their transformations and other properties in both HL gravity and dynamical TNC geometry. We use TNC invariance to construct the effective action for dynamical twistless torsional Newton-Cartan geometries in 2+1 dimensions for dynamical exponent 1Hořava and Melby-Thompson as coming from the Bargmann extension of the local Galilean algebra that acts on the tangent space to TNC geometries. We argue that TNC geometry, which is manifestly diffeomorphism covariant, is a natural geometrical framework underlying HL gravity and discuss some of its implications.

  17. Contribution of the Heart of Borneo (HoB initiative towards botanical exploration in Sabah, Malaysia

    Directory of Open Access Journals (Sweden)

    Suzana Sabran

    2014-12-01

    Full Text Available The Heart of   Borneo (HoB declaration is a conservation agreement initiated by WWF and signed by three countries, i.e., Brunei       Darussalam, Indonesia and Malaysia in Bali, Indonesia on 12th February 2007 to protect more than 23 million hectares of forested region on Borneo Island. These forested areas could be well protected when conservation management plan is in place. One of the crucial activities to facilitate the planning and formulation of conservation plan is to conduct  scientific expeditions that include botanical exploration. The primary objective of the expedition is to identify the key conservation targets within the forest reserves. For the past five years, several expeditions have been conducted by the Sabah Forestry Department under the auspices of the HoB project to explore various forest reserves with conservation issues within the Heart of Borneo area. This paper will present the findings which include plant richness, endemism and plant conservation status in each forest reserves that has been explored. 

  18. The Calculation of Ho Production by indirect Method and Preparation of Polymeric Microsphere for Radioembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, K. H.; Kim, J. B.; Park, U. J.; Cho, E. H.; Nam, S. S.; Yoo, K. M.; Jang, K. D. [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The reactor-produced radiolanthanides have been essential for development of therapeutic radiopharmaceuticals because they emit proper beta energies to induce tumor necrosis. Some radiolanthanides are very useful in that they have the ability of simultaneous diagnosis and therapeutic effect. This nuclide with both capacities is called as theranostic nuclide. In general, radiolanthanides can be produced by (n,γ) and (n,γ)β reaction. Of the two reactions, (n,γ)β reaction-product, shows high specific activity which is important things to affect labeling yield, is suitable for preparing the radiophamaceuticals comprising the antibody or peptide. Some radiolanthanides show the good theranostic effect in that they have proper LET (Linear Energy Transfer) to induce apoptosis for cancer and gamma ray to use as a tracer for cancer diagnosis. Although Ho-166 has been studied for therapeutic purpose since early 1990, production has been limited to direct method. To inject Dy/Ho mixture into the microsphere, we first set-up the concepts which are prior metal-administration method and posterior administration method. The latter is shown in this paper. Metal inletting process was done by using alternating between vacuum and pressurization. To prevent the leak of metal ions from metal/microsphere hybrid, surface coating was done by using interfacial reaction between saline and THF contained Poly lactic acid. Surface coating is simply completed just swiveling the vial. All experiments in this study, we just only tested with cold state.

  19. Dependence of calculus retropulsion dynamics on fiber size and radiant exposure during Ho:YAG lithotripsy.

    Science.gov (United States)

    Lee, Ho; Ryan, Robert T; Kim, Jeehyun; Choi, Bernard; Arakeri, Navanit V; Teichman, Joel M H; Welch, A J

    2004-08-01

    During pulsed laser lithotripsy, the calculus is subject to a strong recoil momentum which moves the calculus away from laser delivery and prolongs the operation. This study was designed to quantify the recoil momentum during Ho:YAG laser lithotripsy. The correlation among crater shape, debris trajectory, laser-induced bubble and recoil momentum was investigated. Calculus phantoms made from plaster of Paris were ablated with free running Ho:YAG lasers. The dynamics of recoil action of a calculus phantom was monitored by a high-speed video camera and the laser ablation craters were examined with Optical Coherent Tomography (OCT). Higher radiant exposure resulted in larger ablation volume (mass) which increased the recoil momentum. Smaller fibers produced narrow craters with a steep contoured geometry and decreased recoil momentum compared to larger fibers. In the presence of water, recoil motion of the phantom deviated from that of phantom in air. Under certain conditions, we observed the phantom rocking towards the fiber after the laser pulse. The shape of the crater is one of the major contributing factors to the diminished recoil momentum of smaller fibers. The re-entrance flow of water induced by the bubble collapse is considered to be the cause of the rocking of the phantom.

  20. Elektrické charakteristiky klouzavého výboje

    OpenAIRE

    Jeřábek, Martin

    2010-01-01

    Předmětem této bakalářské práce bylo seznámit se s vlastnostmi plazmatu, jeho dělením a diagnostikou. Ve fyzice a chemii se za plazma považuje ionizovaný plyn složený z iontů, elektronů (a případně neutrálních atomů a molekul), který vzniká odtržením elektronů z elektronového obalu atomů plynu, či roztržením molekul (ionizací). O plazmatu se často mluví jako o čtvrtém skupenství hmoty. Pozornost byla zaměřena na popsání různých druhů elektrického výboje, jeho vlastností a výskytu. Jeden z nej...