Sample records for hitachi cml190sxw samsung
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Adriany, Nadya
2015-01-01
This study aims to determine the promotion of Samsung Smartphone at Business Administration FISIP USU, to determine the purchasing decision of Samsung Smartphone at Business Administration FISIP USU, and determine how much the promotion influences the purchasing decision of Samsung Smartphone at Business Administration FISIP USU. This research is an associative research with a quantitative approach using a statistical formula that is managed through the application program SPSS 19.0. This ...
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Hitachi's experience and achievements in ABWR construction
International Nuclear Information System (INIS)
Inoue, Takashi; Miura, Jun; Murayama, Kouichi
2003-01-01
Hitachi, Ltd. (Hitachi) is taking charge of the turbine island of Chubu Electric Power Company's Hamaoka nuclear power plant Unit No. 5 (Hamaoka 5), and all facilities of Hokuriku Electric Power Company's Shika Nuclear Power Station Unit No. 2 (Shika 2). Hitachi has achieved shorter schedules and lower costs in the two projects with the following construction methods. First, Hitachi applied modularization and the area-by-area method. These methods enable us to undertake building and installation work in parallel. Second, the floor packaging construction method enables us to finish installation in every area earlier than conventional methods. Moreover, manpower can be distributed evenly. This paper reports the application of these advanced construction methods to the Hamaoka 5 and Shika 2 projects. Installations such as RCCV modules and condenser blocks are presented in this paper. In addition, Hitachi is using 3D-CAD engineering and our own construction management system to optimize the planning of construction procedures and the installation of equipment in these projects. Thus Hitachi is always striving to improve the reliability, safety and economy of ABWR construction technologies. (author)
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Strategy of plant concept development in Hitachi
International Nuclear Information System (INIS)
Kumiaki, Moriya
2007-01-01
Hitachi contributes to the society in various fields of nuclear power such as the Light Water Reactor field, the Fast Breeder Reactor, the fuel cycle, and the medical treatment. Since the beginning of a first commercial operation of a BWR in Japan, Hitachi has constructed 20 units of BWR. Hitachi continues its efforts in achieving high reliability and large-scale output, and in 1996, it completed Advanced Boiling Water Reactor (ABWR) in cooperation with various BWR utilities, General Electric Company, and Toshiba Corporation. Hitachi has enhanced the ABWR technology further based on the above enough experience. The latest technologies were reflected in Hamaoka unit 5 and Shika unit 2 as the latest ABWR plants. The further upgrade technologies would been reflected in Shimane-3, Ohma-1 and Higashidori-1 as ABWR plants under planning. Hitachi obtains the chance to construct the nuclear power plant continuously. For the next generation, Hitachi is working on developing nuclear power plants that take diversified needs and global characteristics into account. As one of the approaches, the output series formation of BWR is extended as the following. ABWR-II and ESBWR (Economic and Simplified BWR) as a large-scale centralized power supply emphasizing cost efficiency, Medium size ABWR and natural circulation type BWR as medium and small-scale distributed power supply that features flexibility to various market needs, such as minimized capital risks, timely return on a capital investment, etc. As another approach, Hitachi tries to extend the Light Water Reactor technology. RBWR (Resource-Renewable BWR ) that achieves a high conversion ratio over 1.0 based on the BWR technology will make the fuel cycle flexible. Hitachi will continue the challenge for the next ABWR and the future with the enough experience of BWR construction. (author)
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Lele, Aco
2017-01-01
This study aims to identify and analyze: 1) the level of importance of Modern Marketing Management variable that includes People, Process, Programs and Performance to meet customer's satisfaction in Samsung Mobile Phones purchasing at Samsung Brand Store in Palu City; 2) significant influence of Modern Marketing Management (People, Process, Programs and Performance) simultaneously and partially on customer's satisfaction in Samsung Mobile Phones purchasing at Samsung Brand Store in Palu City....
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Mufarihah, Hanik; -, Triyono
2013-01-01
The purpose of this research is to determine the influence of advertising on buyer interest of Samsung Galaxy cell phone user in Semarang. Knowing and analyzing what factor of the message in the advertisement, the model of the advertisement, and the frequency of the advertisement broadcast on the television can influence the buying interest of Samsung Galaxy cell phone users. This research also determines which factor that has big influence on buying interest of Samsung Galaxy cell phone user...
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75 FR 21680 - GE-Hitachi Global Laser Enrichment LLC;
2010-04-26
... Global Laser Enrichment LLC; Establishment of Atomic Safety and Licensing Board Pursuant to delegation by... over the following proceeding: GE-Hitachi Global Laser Enrichment LLC (GLE Commercial Facility) This... application of GE-Hitachi Global Laser Enrichment LLC for a license to possess and use source, byproduct, and...
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2010-03-02
... Semiconductor, LLC, DRAM Fab 1, a Subsidiary of Samsung Electronics Corporation, Including On-Site Leased... Semiconductor, LLC, a subsidiary of Samsung Electronics Corporation, DRAM Fab 1, including on-site leased.... The workers are engaged in activities related to the production of DRAM chips for use in electronics...
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Current Hitachi knowledge engineering systems: an overview
Energy Technology Data Exchange (ETDEWEB)
Masui, S; Maeda, A; Masuishi, T [Hitachi, Ltd., Tokyo (Japan)
1992-02-01
In order to bring the knowledge engineering technology up to the practical phase, Hitachi has provided several knowledge engineering system products, including expert system building tools, knowledge acquisition tools, and many kinds of stand-alone and build-in expert systems in both the business and process control fields. In this review article, an overview of Hitachi{prime}s recent knowledge systems is described, which includes a trend analysis on recent market recognition. In addition, to introduce the Hitachi{prime}s current activities, a new product, a user interface building tool, and a new method of tuning fuzzy membership functions using a neuro-computing algorithm are also described. Furthermore, it is pointed out that not only practical tools and methodologies, but also a practical development team, including a planning section, a cooperating expert, a user section, and experienced knowledge engineers, is needed to achieve practical expert systems. 20 refs., 10 figs., 1 tab.
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Hughes, Bill
2015-01-01
Explore the capabilities of your Samsung Galaxy S 6 with this definitive guide! Learning to use a new phone can be both difficult and frustrating. With confusing documentation and baffling support, the references provided by phone manufacturers can be intimidating. Enter Samsung Galaxy S 6 For Dummies! This extensive yet practical guide walks you through the most useful features of your new Samsung Galaxy S 6-and it shows you all the best tricks to getting the most out of your device. With an accessible and fun, yet informative writing style, this is a text that you'll refer to again and agai
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Strategi Bisnis Teknologi Informasi pada Perusahaan Hitachi, Ltd.
Directory of Open Access Journals (Sweden)
Tri Pudjadi
2013-12-01
Full Text Available Information technology (IT application for corporate is now a very common thing. It brings many benefits, such as improving business performance, minimizing marketing cost and time, and minimizing the risk in doing business. Hitachi, Ltd. relies on information technology for the company's progress. Various IT strategies performed by Hitachi, Ltd. for improving the quality of their business which one of them is implementing enterprise resource planning (ERP system of Microsoft Dynamics Navision as its core business application. As a business management software, this system connects many components of the organization by presenting a comprehensive business management functionality-from the financial sector to supply chain. Nevertheless, one of the shortcomings of ERP system is its inefficient schedule solution. Therefore, Hitachi, Ltd. implements a lot of strategies, beside ERP, to survive in the competitive business world of information technology.
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Hughes, Bill
2014-01-01
Explore Samsung's next generation Galaxy smartphone Do you want an easy-to-follow guide to everything your new Galaxy S5 smartphone can do? From the basics of texting and accessing the Internet to the most advanced features and new software apps, Samsung Galaxy S5 For Dummies makes the need for tech support obsolete. The Galaxy S5 is designed to be faster and more powerful than ever. This latest release in the market-leading line of smartphones is full of new features for you to explore with the help of Samsung Galaxy S5 For Dummies. With over 1 million apps available for the Google Android o
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HITACHI security concept for industrial control systems
International Nuclear Information System (INIS)
Endoh, H.; Yamada, T.; Okubo, S.; Nakano, T.
2012-01-01
Security is a necessary factor for the safe and efficient operation of today's control systems. To ensure safe operation of control systems throughout their lifetime, security measures must be carefully planned in the development phase and then maintained continuously during the operation phase and other following phases. To ensure operation within the system's safe states, Hitachi proposes security concept processes (1) to derive security measures rationally and (2) to maintain the security model over the system life cycle. Hitachi also proposes security development programs which support the integration of standards-compliant systems and development of robust control equipment. (author)
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An Overview of medical solution business of Hitachi group
International Nuclear Information System (INIS)
Ninomiya, Ken; Tao, Ryuji; Umegaki, Kikuo; Hashizume, Akihide; Watanabe, Shigeru
2006-01-01
Hitachi is promoting the medicare business in the medical fields of imaging diagnosis, external diagnosis, medical information, treatment support and medical service with the concept that advancement of medical technology is essential for health and this paper describes its major details including research/development. In imaging diagnosis, Hitachi has apparatuses for MRI, X-ray radiography, X-CT, ultrasonography and PET, which are being subject to continuous technological improvement for patients (the principle, Patient Friendly). Clinical laboratory test equipments are in external diagnosis, where ''LABOSPECT series'', a support system for clinical chemistry, has been recently marketed. Medical information involves the total health-care system of people to connect the medical facilities (e.g., POMR, problem oriented medical record) and national medical institutions (e.g., IHE-J, integrating the healthcare enterprise-Japan). One of topics of Hitachi's res/dev is the molecular imaging like PET equipped with high magnetic field MRI and semi-conductor detector and, the other, targeting therapy with proton accelerator already operating in Tsukuba University and to be operated in The University of Texas. Hitachi is working for turning the dream of healthy and safe society into reality through technology. (T.I.)
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JUMAELA KADDAS, ANDI GUSTI
2008-01-01
2013 This research aims to analyze the brand image against the decision of buying the Samsung galaxy tab on of PT. Samsung Branch Makassar. The data were obtained from questionnaires (primary) and some observations as well as interviews with relevant parties. The findings showed that the variables that comprise the brand image keungglan brand association, brand association strength, uniqueness of brand association jointly significant influence on the purchase decision variables at a signif...
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Immediate behavioural responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan.
Lindell, Michael K; Prater, Carla S; Wu, Hao Che; Huang, Shih-Kai; Johnston, David M; Becker, Julia S; Shiroshita, Hideyuki
2016-01-01
This study examines people's immediate responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch and 332 respondents in Hitachi revealed notable similarities between the two cities in people's emotional reactions, risk perceptions, and immediate protective actions during the events. Respondents' physical, household, and social contexts were quite similar, but Hitachi residents reported somewhat higher levels of emotional reaction and risk perception than did Christchurch residents. Contrary to the recommendations of emergency officials, the most frequent response of residents in both cities was to freeze. Christchurch residents were more likely than Hitachi residents to drop to the ground and take cover, whereas Hitachi residents were more likely than Christchurch residents to evacuate immediately the building in which they were situated. There were relatively small correlations between immediate behavioural responses and demographic characteristics, earthquake experience, and physical, social, or household context. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.
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Supplier Partnership Strategy and Global Competitiveness: A Case of Samsung Electronics
Directory of Open Access Journals (Sweden)
Jangwoo Lee
2015-11-01
Full Text Available Samsung Group has accelerated its management innovation process, following the announcement of ‘New Management’ by the CEO Lee Kun-Hee. Particular attention must be paid to the smart-phone business of Samsung Electronics, which is the core company of the Samsung Group. In 2009, as Apple entered into the Korean market, the domestic smart-phone market faced the so called ‘Apple Shock’ due to its choice of a monopolistic and closed operating system. In response, Samsung Electronics introduced the innovative Galaxy series, replacing the old model of Omnia series. This move reaped dramatic success by dominating the world smart-phone market. Samsung Electronics ranked first in the 2012 world smart-phone market, and in 2013 it sold over 300 million devices for the first time in history, thereby solidifying the number one spot with a market share of 32.3%. Samsung Electronics’ achievement in its management innovation process was successful, due to its internal innovation and its partnership with sub-suppliers. Samsung Electronics strengthened its supplier partnership strategy, which in turn, led to an internalization of subparts assembly and process technology. By conducting the final assembly process on its own, it established the global supply chain that accompanies a high level of efficiency and operational elasticity. Samsung Electronics successfully systemized several hundred suppliers into an effective partnership and created an eco system where cooperation and competition can co-exist in its supply chain network. In sum, Samsung Electronics has successfully created the Samsung Production System that brings an economy of scale and allows prompt response. On the other hand, Apple did not get involved with subparts production, besides design and product design. This research identifies the effectiveness of Samsung Electronics’ supplier partnerships in its global competitiveness by examining characteristics of supplier partnership
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Supplier Partnership Strategy and Global Competitiveness: A Case of Samsung Electronics
Jangwoo Lee; Kapsoo Lee; Junseok Heo
2015-01-01
Samsung Group has accelerated its management innovation process, following the announcement of ‘New Management’ by the CEO Lee Kun-Hee. Particular attention must be paid to the smart-phone business of Samsung Electronics, which is the core company of the Samsung Group. In 2009, as Apple entered into the Korean market, the domestic smart-phone market faced the so called ‘Apple Shock’ due to its choice of a monopolistic and closed operating system. In response, Samsung Electronics introduced th...
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Interdisciplinary Integrated Engineering Development Course in HITACHI
Ojima, Masahiro
As an example of interdisciplinary education for engineers in private companies, IED (Integrated Engineering Development) course at HITACHI Ltd. is presented. To help 30 years old or so promising engineers create a new product based on a new technology, one year term course is designed for four types of engineers; mechanical, electric & electronic, information software, and digital systems. Each course has core basic technologies plus related supplementary subjects to promote an interdisciplinary integrated engineer. Not only lectures given by university professors but heavy duty home work is also given by senior engineers of HITACHI to make them apply basic theory to practical problems. Furthermore, self development planning, leadership development program and technology-marketing project are introduced to promote human skills and business sense needed for technology leaders in company.
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International Nuclear Information System (INIS)
Kaizuka, T.; Suzuki, M.
2006-01-01
In order to raise a red bunching onion, a thick leaf sheath with stabilized coloring, breeding has been carried out since 1984. 'Hitachi-benikko' was developed in 1997.It was selected from soft X-ray irradiated seeds in 1996, between crossing of ('Chouetsu' x 'A3-middle') x 'Akasyonai-strain'. The color of the leaf sheath in 'Hitachi-benikko' is stabilizes deep and the leaf sheath of 'Hitachi-benikko' is thick, because it has fewer tillers than 'Benizome'. If 'Hitachi-benikko' is planted in autumn, the growth and development increases, and the quality of the leaf shealth is greater than planting in spring. Standard amount of applied fertilizer is the best because a 20% reduction in amount of application slightly decreases the growth and development of 'Hitachi-benikko'. If the spacing between plants is 15 cm or 20 cm, the growth and development increases, and the quality of the leaf shealth is greater than 5 cm or 10 cm in 'Hitachi-benikko'
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Zhu, Xiaoyang; Perez, Manon; Aldon, Didier; Galaud, Jean-Philippe
2017-05-04
In their natural environment, plants have to continuously face constraints such as biotic and abiotic stresses. To achieve their life cycle, plants have to perceive and interpret the nature, but also the strength of environmental stimuli to activate appropriate physiological responses. Nowadays, it is well established that signaling pathways are crucial steps in the implementation of rapid and efficient plant responses such as genetic reprogramming. It is also reported that rapid raises in calcium (Ca 2+ ) levels within plant cells participate in these early signaling steps and are essential to coordinate adaptive responses. However, to be informative, calcium increases need to be decoded and relayed by calcium-binding proteins also referred as calcium sensors to carry-out the appropriate responses. In a recent study, we showed that CML8, an Arabidopsis calcium sensor belonging to the calmodulin-like (CML) protein family, promotes plant immunity against the phytopathogenic bacteria Pseudomonas syringae pv tomato (strain DC3000). Interestingly, other CML proteins such as CML9 were also reported to contribute to plant immunity using the same pathosystem. In this addendum, we propose to discuss about the specific contribution of these 2 CMLs in stress responses.
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Chronic myelogenous leukemia (CML)
CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...
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2012-03-05
... for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential Refrigerator... the Samsung Electronics America, Inc. (Samsung) petition for waiver (hereafter, ``petition'') from... consumption of electric refrigerators and refrigerator-freezers. In its petition, Samsung provides an...
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2013-07-05
..., Texas; Notification of Proposed Production Activity; Samsung Austin Semiconductor, LLC (Semiconductors); Austin, Texas Samsung Austin Semiconductor, LLC (Samsung), operator of Subzone 183B, submitted a... June 26, 2013. Samsung currently has authority to produce semiconductor memory devices for export...
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2012-03-06
... NUCLEAR REGULATORY COMMISSION [NRC-2009-0157] General Electric-Hitachi Global Laser Enrichment, LLC, Proposed Laser-Based Uranium Enrichment Facility, Wilmington, NC AGENCY: Nuclear Regulatory... Impact Statement (EIS) for the proposed General Electric- Hitachi Global Laser Enrichment, LLC (GLE...
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2010-04-16
... Conservation Program for Consumer Products: Notice of Petition for Waiver of Samsung Electronics America, Inc.... SUMMARY: This notice announces receipt of and publishes the Samsung Electronics America, Inc. (Samsung... refrigerator-freezers to additional Samsung basic models. Through this document, DOE also solicits comments...
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2013-03-13
... for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential Refrigerator... receipt of a petition for waiver from Samsung Electronics America, Inc. (Samsung) seeking an exemption... energy consumption of electric refrigerators and refrigerator-freezers. Samsung asks that it be permitted...
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2010-09-23
... Conservation Program for Consumer Products: Notice of Petition for Waiver of Samsung Electronics America, Inc... announces receipt of and publishes the Samsung Electronics America, Inc. (Samsung) petition for waiver... clothes washer test procedure. Through this notice, DOE also solicits comments with respect to the Samsung...
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2013-06-14
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Refrigerator and... decision and order (Case No. RF-026) that grants to Samsung Electronics America, Inc. (Samsung) a waiver... forth in its petition for waiver. In its petition, Samsung provides an alternate test procedure to...
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2013-06-14
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Refrigerator and... decision and order in Case No. RF-027 that grants to Samsung Electronics America, Inc. (Samsung) a waiver... set forth in its petition for waiver. In its petition, Samsung provides an alternate test procedure...
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2013-11-01
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Refrigerator and... decision and order in Case No. RF-032 that grants to Samsung Electronics America, Inc. (Samsung) a waiver... set forth in its petition for waiver. In its petition, Samsung provides an alternate test procedure...
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2013-06-14
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Refrigerator and... decision and order in Case No. RF-025 that grants to Samsung Electronics America, Inc. (Samsung) a waiver... set forth in its petition for waiver. In its petition, Samsung provides an alternate test procedure...
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2012-12-20
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Refrigerator and... decision and order (Case No. RF-021) that grants to Samsung Electronics America, Inc. (Samsung) a waiver... forth in its petition for waiver in Case RF-021. In its petition, Samsung provides an alternate test...
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2013-02-21
... Petition for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential... the Samsung Electronics America, Inc. (Samsung) petition for waiver (hereafter, ``petition'') from... consumption of electric refrigerators and refrigerator-freezers. In its petition, Samsung provides an...
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2011-03-16
... NUCLEAR REGULATORY COMMISSION [NRC-2011-0055] Economic Simplified Boiling Water Reactor Standard Design: GE Hitachi Nuclear Energy; Issuance of Final Design Approval The U.S. Nuclear Regulatory Commission has issued a final design approval (FDA) to GE Hitachi Nuclear Energy (GEH) for the economic...
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2013-11-01
... Petition for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential... waiver from Samsung Electronics America, Inc. (Samsung) regarding specified portions of the U.S... and refrigerator-freezers. In its petition, Samsung provides an alternate test procedure that is the...
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2013-03-13
... Petition for Waiver of Samsung Electronics America, Inc. from the Department of Energy Residential... waiver from Samsung Electronics America, Inc. (Samsung) regarding specified portions of the U.S... and refrigerator-freezers. In its petition, Samsung provides an alternate test procedure that is the...
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2013-09-17
... Petition for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential... waiver from Samsung Electronics America, Inc. (Samsung) regarding specified portions of the U.S... and refrigerator-freezers. In its petition, Samsung provides an alternate test procedure that is the...
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2011-04-19
... Conservation Program for Consumer Products: Notice of Petition for Waiver of Samsung Electronics America, Inc... comments. SUMMARY: This notice announces receipt of and publishes the Samsung Electronics America, Inc. (Samsung) petition for waiver and application for [[Page 21882
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International Nuclear Information System (INIS)
Zhang, ZiJian; Kakitani, Shunsuke; Ninomiya, Kazuhiko; Takahashi, Naruto; Shinohara, Atsushi; Yamaguchi, Yoshiaki; Yoshimura, Takashi; Kita, Kazuyuki; Watanabe, Akira
2013-01-01
Our group started gamma ray measurement of air dust sample after the Fukushima Dai-ichi nuclear power station accident. Air dust filters was collected at Hitachi, Fukushima and Marumori. The activity of Cs-134 and Cs-137 was determined by germanium semiconductor detector. The radiocesium activity concentration in air dust(Bq/m"3) after October 2011 were stable and 6.2×10"-"6 at Hitachi, 3.0×10"-"4 at Fukushima and 1.3×10"-"4 at Marumori. (author)
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2011-11-16
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Clothes Washer Test... No. CW-020) that grants to Samsung Electronics America, Inc. (Samsung) a waiver from the DOE clothes... forth in its petition for waiver. Under today's decision and order, Samsung shall be required to test...
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2011-08-12
... and Order Granting a Waiver to Samsung From the Department of Energy Residential Clothes Washer Test... No. CW-019) that grants to Samsung Electronics America, Inc. (Samsung) a waiver from the DOE clothes... forth in its petition for waiver. Under today's decision and order, Samsung shall be required to test...
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A power-efficient switchable CML driver at 10 Gbps
Peipei, Chen; Lei, Li; Huihua, Liu
2016-02-01
High static power limits the application of conventional current-mode logic(CML). This paper presents a power-efficient switchable CML driver, which achieves a significant current saving by 75% compared with conventional ones. Implemented in the 130 nm CMOS technology process, the proposed CML driver just occupies an area about 0.003 mm2 and provides a robust differential signal of 1600 mV for 10 Gbps optical line terminal (OLT) with a total current of 10 mA. The peak-to-peak jitter is about 4 ps (0.04TUI) and the offset voltage is 347.2 mV @ 1600 mVPP.
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International Nuclear Information System (INIS)
Akagi, K.; Morita, K.; Miyahara, R.; Murayama, K.; Deir, C.; Akahori, S.
2008-01-01
Shika Nuclear Power Station Unit No.2 began commercial operation in March 2006 as one of the latest new-build projects in the world. Hitachi-GE Nuclear Energy Ltd. (Hitachi) was the main contractor and supplied the entire plant including engineering, manufacturing of all major reactor and turbine-generator components, and executed the installation and commissioning. Hitachi completed the project on schedule and on budget owing in large part to its highly reliable advanced construction technology. This article describes Hitachi's unsurpassed advanced construction technology being applied to the current new-build projects in Japan. Furthermore, this article addresses a possible form of applications to new build nuclear power plants in North America. (author)
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Expression, purification and preliminary diffraction studies of CmlS
International Nuclear Information System (INIS)
Latimer, Ryan; Podzelinska, Kateryna; Soares, Alexei; Bhattacharya, Anupam; Vining, Leo C.; Jia, Zongchao; Zechel, David L.
2009-01-01
CmlS from S. venezuelae is a flavin-dependent halogenase that is involved in the biosynthesis of the widely used antibiotic chloramphenicol. Here, the crystallization of CmlS and analysis of the initial diffraction data are reported. CmlS, a flavin-dependent halogenase (FDH) present in the chloramphenicol-biosynthetic pathway in Streptomyces venezuelae, directs the dichlorination of an acetyl group. The reaction mechanism of CmlS is of considerable interest as it will help to explain how the FDH family can halogenate a wide range of substrates through a common mechanism. The protein has been recombinantly expressed in Escherichia coli and purified to homogeneity. The hanging-drop vapour-diffusion method was used to produce crystals that were suitable for X-ray diffraction. Data were collected to 2.0 Å resolution. The crystal belonged to space group C2, with unit-cell parameters a = 208.1, b = 57.7, c = 59.9 Å, β = 97.5°
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Samsung Salmonella Detection Kit. AOAC Performance Tested Method(SM) 021203.
Li, Jun; Cheung, Win Den; Opdyke, Jason; Harvey, John; Chong, Songchun; Moon, Cheol Gon
2012-01-01
Salmonella, one of the most common causes of foodborne illness, is a significant public health concern worldwide. There is a need in the food industry for methods that are simple, rapid, and sensitive for the detection of foodborne pathogens. In this study, the Samsung Salmonella Detection Kit, a real-time PCR assay for the detection of Salmonella, was evaluated according to the current AOAC guidelines. The validation consisted of lot-to-lot consistency, stability, robustness, and inclusivity/exclusivity studies, as well as a method comparison of 10 different food matrixes. In the validation, the Samsung Salmonella Detection Kit was used in conjunction with the Applied Biosystems StepOnePlus PCR system and the Samsung Food Testing Software for the detection of Salmonella species. The performance of the assays was compared to the U.S. Department of Agriculture/Food Safety and Inspection Service-Microbiology Laboratory Guidebook (USDA/FSIS-MLG) 4.05: Isolation and Identification of Salmonella from Meat, Poultry, Pasteurized Egg, and Catfish and the and U.S. Food and Drug Administration/Bacteriological Analytical Manual (FDA/BAM) Chapter 5 Salmonella reference methods. The validation was conducted using an unpaired study design for detection of Salmonella spp. in raw ground beef, raw pork, raw ground pork, raw chicken wings, raw salmon, alfalfa sprouts, pasteurized orange juice, peanut butter, pasteurized whole milk, and shell eggs. The Samsung Salmonella Detection Kit demonstrated lot-to-lot consistency among three independent lots as well as ruggedness with minor modifications to changes in enrichment incubation time, enrichment incubation temperature, and DNA sample volume for PCR reaction. Stability was observed for 13 months at -20 degrees C and 3 months at 5 degrees C. For the inclusivity/exclusivity study, the Samsung Salmonella Detection Kit correctly identified 147 Salmonella species isolates out of 147 isolates tested from each of three different enrichment
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A power-efficient switchable CML driver at 10 Gbps
International Nuclear Information System (INIS)
Chen Peipei; Li Lei; Liu Huihua
2016-01-01
High static power limits the application of conventional current-mode logic(CML). This paper presents a power-efficient switchable CML driver, which achieves a significant current saving by 75% compared with conventional ones. Implemented in the 130 nm CMOS technology process, the proposed CML driver just occupies an area about 0.003 mm 2 and provides a robust differential signal of 1600 mV for 10 Gbps optical line terminal (OLT) with a total current of 10 mA. The peak-to-peak jitter is about 4 ps (0.04T UI ) and the offset voltage is 347.2 mV @ 1600 mV PP . (paper)
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Veronica
2016-01-01
Purposes of this study is to determine the role of attitudes, subjective norms, and perceived behavioral control of the intention to buy Samsung smart TV and the role of each aspect on the intention to buy Samsung smart TV. The hypothesis of this research was that attitudes, subjective norms, and perceived behavioral control were positive predictor of intention to buy Samsung smart TV. This study used the quantitative approach using a hundred peoples selected using incidental sampling. The...
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Hitachi's proposed DCS solution for new build CANDU EC6 using the G-HIACS unified platform
Energy Technology Data Exchange (ETDEWEB)
Tan, D.; Ishii, K.; Otsuka, Y.; Uemura, K., E-mail: daisuke.tan.ye@hitachi.com [Hitachi Ltd., Infrastructure Systems Co., Ibaraki (Japan); Marko, P.E. [Hitachi Power Systems Canada Ltd., Power and Industry Div., Ontario (Canada)
2013-07-01
Hitachi Ltd. has developed the safe and secure functional safety DCS controller for potential new build NPP projects in the global market. Hitachi has improved the availability, maintainability, and reliability for its latest DCS systems named G-HIACS. In this latest paper on its DCS product development program, Hitachi would like to report a proposed DCS solution for new build CANDU NSP and BOP based on the G-HIACS Unified Architecture (R800FS/HSC800FS vSAFE Functional Safety Controller and R900/HSC900 General Purpose Controller) hybrid control system. (author)
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International Nuclear Information System (INIS)
Zhou Hongsheng; Zhang Donghua; Wang Yaya; Dai Ming; Zhang Lu; Liu Wenli; Liu Dan; Tan Huo; Huang Zhenqian
2006-01-01
CML28 is an attractive target for antigen-specific immunotherapy. SOCS1 represents an inhibitory control mechanism for DC antigen presentation and the magnitude of adaptive immunity. In this study, we evaluated the potential for inducing CML28-specific cytotoxic T lymphocytes (CTL) responses by dendritic cells (DCs)-based vaccination. We constructed a CML28 DNA vaccine and a SOCS1 siRNA vector and then cotransfect monocyte-derived DCs. Flow cytometry analysis showed gene silencing of SOCS1 resulted in higher expressions of costimulative moleculars in DCs. Mixed lymphocyte reaction (MLR) indicated downregulation of SOCS1 stronger capability to stimulate proliferation of responder cell in DCs. The CTL assay revealed transfected DCs effectively induced autologous CML28-specific CTL responses and the lytic activities induced by SOCS1-silenced DCs were significantly higher compared with those induced by SOCS1-expressing DCs. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs
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Las Redes Sociales en el Marketing Digital: el comportamiento de Samsung Mobile
García Mondelo, Raquel María
2013-01-01
Se analiza el comportamiento de Samsung a través de las redes sociales y cómo esto afecta a los usuarios. La información que recogen estas plataformas sobre la marca y cómo lo hacen será una de las acciones más importantes para reunir los datos necesarios sobre Samsung
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2012-11-16
... today's decision and order, Samsung shall be required to test and rate its variable capacity Digital.... Samsung requested the waiver for the specified basic model of Samsung's variable capacity Digital Variable... representations about the energy efficiency of its DVM multi-split equipment, for compliance, marketing, or other...
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2012-01-10
.... RF-019] Decision and Order Granting a Waiver to Samsung From the Department of Energy Residential... of the decision and order (Case Nos. RF-018, RF-019) that grants to Samsung Electronics America, Inc. (Samsung) a waiver from the DOE electric refrigerator and refrigerator-freezer test procedures for the...
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Training to Improve New Product Sales Performance: The Case of Samsung in China
Fu, Frank Q.; Yi, Hong; Zhai, Nanji
2013-01-01
The authors report a case study conducted with over 8,000 Samsung salespeople in the Chinese market. Using research-oriented, evidence-based, and systematic approaches, training professionals contributed to Samsung's business outcomes at multiple levels. The case highlights the valuable impacts of training on salespeople's behaviors and new…
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2011-01-27
... NUCLEAR REGULATORY COMMISSION [NRC-2011-0020] GE Hitachi Nuclear Energy; Notice of Receipt and... December 7, 2010, GE Hitachi Nuclear Energy (GEH) filed with the U.S. Nuclear Regulatory Commission (NRC..., Certifications, and Approvals for Nuclear Power Plants,'' an application for a design certification (DC) renewal...
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Emor, Angelina M.
2015-01-01
Consumers nowadays tend to value a product from its brand. Strong brand equity brings positive effect to the product. Thus, it is assumed that brand equity affects preference and purchase intention as well. Samsung has become popular in the Smartphone market these years. Currently, Samsung holds the place at the top of Android-based Smartphones globally. This research wants to study about the effect of brand equity on purchase intention through brand preference of Samsung Smartphone users in ...
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2011-08-08
... Petition for Waiver of Samsung Electronics America, Inc. From the Department of Energy Residential Clothes..., and request for comments. SUMMARY: This notice announces receipt of and publishes the Samsung Electronics America, Inc. (Samsung) petition for waiver and application for interim waiver (hereafter...
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Anggaeni, Maya; Farida, Naili; Listyorini, Sari
2015-01-01
This research is motivated their smartphone trends in society as well as themore famous brand Samsung in the community. In addition to improvements in thebrand image of Samsung, Samsung also increased sales both at the global level as wellas in Indonesia, however, the increased sales of Samsung have not made the Samsungranked number one in the Top Brand Index from 2012 to 2014. The sample are 100person of smartphone Samsung Galaxy consumers. The results showed that the effect ofpartially or s...
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2013-11-15
... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-70-2013] Subzone 183B; Authorization of Production Activity; Samsung Austin Semiconductor, LLC (Semiconductors); Austin, Texas On June 26, 2013, Samsung Austin Semiconductor, LLC submitted a notification of proposed export production activity to the...
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D Modelling with the Samsung Gear 360
Barazzetti, L.; Previtali, M.; Roncoroni, F.
2017-02-01
The Samsung Gear 360 is a consumer grade spherical camera able to capture photos and videos. The aim of this work is to test the metric accuracy and the level of detail achievable with the Samsung Gear 360 coupled with digital modelling techniques based on photogrammetry/computer vision algorithms. Results demonstrate that the direct use of the projection generated inside the mobile phone or with Gear 360 Action Direction (the desktop software for post-processing) have a relatively low metric accuracy. As results were in contrast with the accuracy achieved by using the original fisheye images (front and rear facing images) in photogrammetric reconstructions, an alternative solution to generate the equirectangular projections was developed. A calibration aimed at understanding the intrinsic parameters of the two lenses camera, as well as their relative orientation, allowed one to generate new equirectangular projections from which a significant improvement of geometric accuracy has been achieved.
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2011-12-27
...] Publication of the Petition for Waiver From Samsung Electronics America, Inc. and Granting of the Interim... notice announces receipt of and publishes a petition for waiver from Samsung Electronics America, Inc. (Samsung). The petition for waiver (hereafter ``petition'') requests a waiver from the U.S. Department of...
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Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML.
Directory of Open Access Journals (Sweden)
Young Kwang Chae
2008-07-01
Full Text Available Aquaporins (AQPs have previously been associated with increased expression in solid tumors. However, its expression in hematologic malignancies including CML has not been described yet. Here, we report the expression of AQP5 in CML cells by RT-PCR and immunohistochemistry. While normal bone marrow biopsy samples (n = 5 showed no expression of AQP5, 32% of CML patient samples (n = 41 demonstrated AQP5 expression. In addition, AQP5 expression level increased with the emergence of imatinib mesylate resistance in paired samples (p = 0.047. We have found that the overexpression of AQP5 in K562 cells resulted in increased cell proliferation. In addition, small interfering RNA (siRNA targeting AQP5 reduced the cell proliferation rate in both K562 and LAMA84 CML cells. Moreover, by immunoblotting and flow cytometry, we show that phosphorylation of BCR-ABL1 is increased in AQP5-overexpressing CML cells and decreased in AQP5 siRNA-treated CML cells. Interestingly, caspase9 activity increased in AQP5 siRNA-treated cells. Finally, FISH showed no evidence of AQP5 gene amplification in CML from bone marrow. In summary, we report for the first time that AQP5 is overexpressed in CML cells and plays a role in promoting cell proliferation and inhibiting apoptosis. Furthermore, our findings may provide the basis for a novel CML therapy targeting AQP5.
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Analysis of Samsung notebook strategy
Xu, Rui
2009-01-01
Under the fast growing background, Notebook industry draws lots attention from IT companies. It is expected that by 2010, the sales of notebook will overrun the sales of desktop. After the SWOT and SPACE analysis, we recommend Samsung to improve from two different perspectives, first, set up a clear and detailed marketing goal and plan, and ensure the enforcing of such strategies. Secondly, manage the distribution channels effectively and efficiently. There are two trends Samsu...
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Turkish Chronic Myeloid Leukemia Study: Retrospective Sectional Analysis of CML Patients
Directory of Open Access Journals (Sweden)
Fahri Şahin
2013-12-01
Full Text Available OBJECTIVE: here have been tremendous changes in treatment and follow-up of patients with chronic myeloid leukemia (CML in the last decade. Especially, regular publication and updating of NCCN and ELN guidelines have provided enermous rationale and base for close monitorization of patients with CML. But, it is stil needed to have registry results retrospectively to evaluate daily CML practices. METHODS: In this article, we have evaluated 1133 patients’ results with CML in terms of demographical features, disease status, response, resistance and use of second-generation TKIs. RESULTS: The response rate has been found relatively high in comparison with previously published articles, and we detected that there was a lack of appropriate and adequate molecular response assessment. CONCLUSION: We concluded that we need to improve registry systems and increase the availability of molecular response assessment to provide high-quality patient care.
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Technical highlights of the latest upgrades to Hitachi's G-HIACS νSAFE functional safety controller
International Nuclear Information System (INIS)
Tan, D.; Ishii, K.; Otsuka, Y.; Uemura, K.; Suenaga, M.; Koyamada, T.
2014-01-01
Hitachi has developed the G-HIACS νSAFE (pronounced 'nu-safe'), a Functional Safety (FS) controller compliant to IEC 61508 SIL 2, in part to satisfy the requirements of control systems for Nuclear Steam Plants (NSP). Hitachi has reported some of the main challenges, counter-measures and improvements encountered and designed during the several phases of development of controller system at previous Canadian Nuclear Society (CNS) Annual Conferences. Hitachi received initial Product Version 1 (PV1) certification from TUV Rheinland in 2010. Since then, additional functional and design improvements and changes have made product re-certification necessary, in order to cover the scope of the additional and improved capabilities. This paper describes some of these Product Version 2 (PV2) capabilities (certified by TUV Rheinland in 2013). (author)
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2011-02-18
... NUCLEAR REGULATORY COMMISSION [Docket No. 52-045; NRC-2011-0020] GE Hitachi Nuclear Energy... Certification On December 7, 2010, GE Hitachi Nuclear Energy (GEH) submitted an application to the U.S. Nuclear... and Approvals for Nuclear Power Plants.'' A notice of receipt and availability of this application was...
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2011-09-01
... for Waiver and Notice of Granting the Application for Interim Waiver of Samsung from the Department of... Public Comments. SUMMARY: This notice announces receipt of and publishes the Samsung Electronics America, Inc. (Samsung) petition for waiver (hereafter, ``petition'') from specified portions of the U.S...
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CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration.
Xu, Suining; Li, Lihua; Yan, Jinchuan; Ye, Fei; Shao, Chen; Sun, Zhen; Bao, Zhengyang; Dai, Zhiyin; Zhu, Jie; Jing, Lele; Wang, Zhongqun
2018-01-01
Among the various complications of type 2 diabetes mellitus, atherosclerosis causes the highest disability and morbidity. A multitude of macrophage-derived foam cells are retained in atherosclerotic plaques resulting not only from recruitment of monocytes into lesions but also from a reduced rate of macrophage migration from lesions. Nε-carboxymethyl-Lysine (CML), an advanced glycation end product, is responsible for most complications of diabetes. This study was designed to investigate the mechanism of CML/CD36 accelerating atherosclerotic progression via inhibiting foam cell migration. In vivo study and in vitro study were performed. For the in vivo investigation, CML/CD36 accelerated atherosclerotic progression via promoting the accumulation of macrophage-derived foam cells in aorta and inhibited macrophage-derived foam cells in aorta migrating to the para-aorta lymph node of diabetic apoE -/- mice. For the in vitro investigation, CML/CD36 inhibited RAW264.7-derived foam cell migration through NOX-derived ROS, FAK phosphorylation, Arp2/3 complex activation and F-actin polymerization. Thus, we concluded that CML/CD36 inhibited foam cells of plaque migrating to para-aorta lymph nodes, accelerating atherosclerotic progression. The corresponding mechanism may be via free cholesterol, ROS generation, p-FAK, Arp2/3, F-actin polymerization. Copyright © 2017 Elsevier Masson SAS. All rights reserved.
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Directory of Open Access Journals (Sweden)
Basrah Saidani
2013-04-01
Full Text Available Generally, the purpose of this research are: 1 to get more knowledge about Advertising, product attributes and the decision to purchase smartphone Samsung Galaxy series,. 2 to get more knowledge about the influence of Advertising to purchasing decisions smartphone Samsung Galaxy series, 3 to get more knowledge about the influence of product attributes to purchasing decisions smartphone Samsung Galaxy series, 4 to get more knowledge about influence of Advertising and product attributes simultaneously the decision to purchase smartphone Samsung Galaxy series. The observation unit in this research is 100 respondents visitors ITC Roxy Mas – Jakarta to purchase smartphone Samsung Galaxy series. Technique of determining the sample using a convenience sampling technique. Data collection techniques using the questionnaire Liker scale from 1 to 5. Descriptive analysis results showed: 1 the Advertising from Samsung Galaxy series is good enough as a whole but still lacking in message Acceptance and message retention. 2 Attribute a good product overall dimesi dominated by product futures, 3 the decision to purchase is dominated by post-purchase where consumers get satisfaction after buying the Samsung Galaxy series. Hypothesis testing results showed: 1 Advertising have a significant effect on purchasing decisions, 2 product attributes have a significant effect on purchasing decisions, 3 Advertising and product attributes a significant effect on purchasing decisions.
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SYAHPUTRA, ANDY
2014-01-01
2014 Penelitian ini bertujuan untuk mengetahui pengaruh ekuitas merek (Brand Equity) terhadap keputusan pembelian konsumen pada produk Samsung Galaxy Tab di Makassar. Data penelitian ini diperoleh dari kusioner (primer) dengan pihak pengguna Samsung Galaxy Tab. Temuan penelitian menunjukkan bahwa variabel brand equity yang terdiri dari dimensi kesadaran merek (brand awareness), kesan kualitas (perceive quality), asosiasi merek (brand ...
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DRUG THERAPY IN THE PROGRESSED CML PATIENT WITH MULTI-TKI FAILURE
Directory of Open Access Journals (Sweden)
Ibrahim C. Haznedaroglu
2015-02-01
Full Text Available The aim of this paper is to outline pharmacotherapy of the ‘third-line management of CML’ (progressive disease course after sequential TKI drugs. Current management of CML with multi-TKI failure is reviewed. TKI (bosutinib, ponatinib, dasatinib, nilotinib and non-TKI (omacetaxine mepussecinate, IFN or PEG-IFN drugs are available. The literature search was made in PubMed with particular focus on the clinical trials, recommendations, guidelines and expert opinions, as well as international recommendations. Progressing CML disease with multi-TKI failure should be treated with alloSCT based on the availability of the donor and EBMT transplant risk scores. The TKI and non-TKI drugs shall be used to get best promising (hematological, cytogenetic, molecular response. During the CP-CML phase of multi-TKI failure, 2nd generation TKIs (nilotinib or dasatinib are used if they remained. Bosutinib and ponatinib (3rd generation TKIs can be administered in triple-TKI failed (imatinib and nilotinib and dasatinib patients. The presence of T315I mutation at any phase requires ponatinib or omacetaxine mepussecinate therapy before allografting. During the AP/BC-CML phase of multi-TKI failure, the most powerful TKI available (ponatinib or dasatinib if remained together with chemotherapy should be given before alloSCT. Monitoring of CML disease and drug off-target risks (particularly vascular thrombotic events are vital.
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Planning and managing a corporate event : case: Event Activation Galaxy Studio Samsung S7/ S7 Edge
Bui, Quyen; Tran, Fa
2017-01-01
The thesis was written about the case: Event Activation Studio Galaxy Samsung S7/S7 Edge. Samsung is a global leading conglomerate company in the technology industry. This thesis discusses how to plan and manage an Event Activation for Samsung. The primary objective of this thesis was to provide a step-by-step guideline for planning and managing a corporate event. This objective was achieved by performing the following tasks: clarifying the influential role of corporate events in marketi...
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Current status of light water reactor and Hitachi's technical improvements for BWR
International Nuclear Information System (INIS)
Miki, Minoru; Ohki, Arahiko.
1984-01-01
Gradual technical improvements in Japan over the years has improved the reliability of light water reactors, and has achieved the highest capacity factor level in the world. Commercial operation of Fukushima 2-2 (1,100 MW) of the Tokyo Electric Power Co. was started in February, 1984, as the first standardized BWR base plant, ushering in a new age of domestic light water reactor technology. The ABWR (1,300 MW class) has been developed as Japan's next generation light water reactor, with construction aimed at the latter half of the 1980's. Hitachi's extensive efforts range from key nuclear equipment to various related robots, directed at improving safety, reliability, and the capacity factor, while reducing radiation exposure. This paper presents an outline of Hitachi's participation in the light water reactor's improvement and standardization, and the current status of our role in the international cooperation plan for the ABWR. (author)
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Directory of Open Access Journals (Sweden)
V. A. Shuvaev
2014-07-01
Full Text Available At present, introduction of target therapy to chronic myelogenous leukemia (CML treatment made CML not life-limiting disorder. The main condition of treatment efficacy is its continuity. The most common causes of dose reduction and CML therapy interruption is hematologic toxicities such as neutropenia and thrombocytopenia. The adverse events correction in these circumstances is vital. Recommendations for neutropenia and thrombocytopenia correction are proposed in this article. The basement and results of the use of granulocyte colony stimulating factor (G-CSF and thrombopoietine receptor agonist for hematologic toxicities correction with clinical case are presented.
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3D MODELLING WITH THE SAMSUNG GEAR 360
Directory of Open Access Journals (Sweden)
L. Barazzetti
2017-02-01
Full Text Available The Samsung Gear 360 is a consumer grade spherical camera able to capture photos and videos. The aim of this work is to test the metric accuracy and the level of detail achievable with the Samsung Gear 360 coupled with digital modelling techniques based on photogrammetry/computer vision algorithms. Results demonstrate that the direct use of the projection generated inside the mobile phone or with Gear 360 Action Direction (the desktop software for post-processing have a relatively low metric accuracy. As results were in contrast with the accuracy achieved by using the original fisheye images (front and rear facing images in photogrammetric reconstructions, an alternative solution to generate the equirectangular projections was developed. A calibration aimed at understanding the intrinsic parameters of the two lenses camera, as well as their relative orientation, allowed one to generate new equirectangular projections from which a significant improvement of geometric accuracy has been achieved.
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Midhat, Ubaid; Ting, Michael K Y; Teresinski, Howard J; Snedden, Wayne A
2018-03-01
We show that the calcium sensor, CML39, is important in various developmental processes from seeds to mature plants. This study bridges previous work on CML39 as a stress-induced gene and highlights the importance of calcium signalling in plant development. In addition to the evolutionarily-conserved Ca 2+ sensor, calmodulin (CaM), plants possess a large family of CaM-related proteins (CMLs). Using a cml39 loss-of-function mutant, we investigated the roles of CML39 in Arabidopsis and discovered a range of phenotypes across developmental stages and in different tissues. In mature plants, loss of CML39 results in shorter siliques, reduced seed number per silique, and reduced number of ovules per pistil. We also observed changes in seed development, germination, and seed coat properties in cml39 mutants in comparison to wild-type plants. Using radicle emergence as a measure of germination, cml39 mutants showed more rapid germination than wild-type plants. In marked contrast to wild-type seeds, the germination of developing, immature cml39 seeds was not sensitive to cold-stratification. In addition, germination of cml39 seeds was less sensitive than wild-type to inhibition by ABA or by treatments that impaired gibberellic acid biosynthesis. Tetrazolium red staining indicated that the seed-coat permeability of cml39 seeds is greater than that of wild-type seeds. RNA sequencing analysis of cml39 seedlings suggests that changes in chromatin modification may underlie some of the phenotypes associated with cml39 mutants, consistent with previous reports that orthologs of CML39 participate in gene silencing. Aberrant ectopic expression of transcripts for seed storage proteins in 7-day old cml39 seedlings was observed, suggesting mis-regulation of early developmental programs. Collectively, our data support a model where CML39 serves as an important Ca 2+ sensor during ovule and seed development, as well as during germination and seedling establishment.
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Directory of Open Access Journals (Sweden)
Aurélie Bedel
Full Text Available Chronic myeloid leukemia disease (CML found effective therapy by treating patients with tyrosine kinase inhibitors (TKI, which suppress the BCR-ABL1 oncogene activity. However, the majority of patients achieving remission with TKI still have molecular evidences of disease persistence. Various mechanisms have been proposed to explain the disease persistence and recurrence. One of the hypotheses is that the primitive leukemic stem cells (LSCs can survive in the presence of TKI. Understanding the mechanisms leading to TKI resistance of the LSCs in CML is a critical issue but is limited by availability of cells from patients. We generated induced pluripotent stem cells (iPSCs derived from CD34⁺ blood cells isolated from CML patients (CML-iPSCs as a model for studying LSCs survival in the presence of TKI and the mechanisms supporting TKI resistance. Interestingly, CML-iPSCs resisted to TKI treatment and their survival did not depend on BCR-ABL1, as for primitive LSCs. Induction of hematopoietic differentiation of CML-iPSC clones was reduced compared to normal clones. Hematopoietic progenitors obtained from iPSCs partially recovered TKI sensitivity. Notably, different CML-iPSCs obtained from the same CML patients were heterogeneous, in terms of BCR-ABL1 level and proliferation. Thus, several clones of CML-iPSCs are a powerful model to decipher all the mechanisms leading to LSC survival following TKI therapy and are a promising tool for testing new therapeutic agents.
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Payandeh, Mehrdad; Sadeghi, Edris; Khodarahmi, Reza; Sadeghi, Masoud
2014-10-01
Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly (>43 year). However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. In our report, a 52-year-old female was diagnosed with CLL (type of bone marrow (BM) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months after the diagnosis of CLL, she developed CML. She was treated with imatinib (400mg/day). After a few months, signs of CML were disappeared and CLL became dominant. This is first reported case.
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Fakhri, Yadolah; Alinejad, Azim; Keramati, Hassan; Bay, Abotaleb; Avazpour, Moayed; Zandsalimi, Yahya; Moradi, Bigard; Rasouli Amirhajeloo, Leila; Mirzaei, Maryam
2016-09-01
The use of smart phones is increasing in the world. This excessive use, especially in the last two decades, has created too much concern on the effects of emitted electromagnetic fields and specific absorption rate on human health. In this descriptive-analytical study of the electric field resulting from smart phones of Samsung and Nokia by portable measuring device, electromagnetic field, Model HI-3603-VDT/VLF, were measured. Then, head absorption rate was calculated in these two mobiles by ICNIRP equation. Finally, the comparison of specific absorption rate, especially between Samsung and Nokia smart phones, was conducted by T-Test statistics analysis. The mean of electric field for Samsung and Nokia smart mobile phones was obtained 1.8 ±0.19 v/m and 2.23±0.39 v/m , respectively, while the range of the electric field was obtained as 1.56-2.21 v/m and 1.69-2.89 v/m for them, respectively. The mean of specific absorption rate in Samsung and Nokia was obtained 0.002 ± 0.0005 W/Kg and 0.0041±0.0013 W/Kg at the frequency of 900 MHz and 0.004±0.001 W/Kg and 0.0062±0.0002 W/Kg at the frequency of 1800 MHz respectively. The ratio of mean electronic field to guidance in the Samsung mobile phone at the frequency of 900 MHz and 1800 MHz was 4.36% and 3.34%, while was 5.62% and 4.31% in the Nokia mobile phone, respectively. The ratio of mean head specific absorption rate in smart mobile phones of Samsung and Nokia in the guidance level at the frequency of 900 was 0.15% and 0.25%, respectively, while was 0.23 %and 0.38% at the frequency of 1800 MHz, respectively. The rate of specific absorption of Nokia smart mobile phones at the frequencies of 900 and 1800 MHz was significantly higher than Samsung (p value Samsung smart mobile phone.
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Influence of Samsung Marketing Tools to Smartphone Purchase Intention of Manado Youth People
Manoa, Giovanny Guruh
2014-01-01
Smartphone has been quite a phenomenon especially in Manado city when finding people own more than one is easy. There are so many company involves in Smartphone market one of them is Samsung a Korean company who has been selling many Smartphone despite of a raging battle of competitions, this has become a questions for many people. The purpose of this research is to find out how Samsung influence the purchase intentions of a young people the most fertile segment in gadget market through their...
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Frequency of BCR-ABL Transcript Types in Syrian CML Patients
Directory of Open Access Journals (Sweden)
Sulaf Farhat-Maghribi
2016-01-01
Full Text Available Background. In Syria, CML patients are started on tyrosine kinase inhibitors (TKIs and monitored until complete molecular response is achieved. BCR-ABL mRNA transcript type is not routinely identified, contrary to the recommendations. In this study we aimed to identify the frequency of different BCR-ABL transcripts in Syrian CML patients and highlight their significance on monitoring and treatment protocols. Methods. CML patients positive for BCR-ABL transcripts by quantitative RT-PCR were enrolled. BCR-ABL transcript types were investigated using a home-made PCR method that was adapted from published protocols and optimized. The transcript types were then confirmed using a commercially available research kit. Results. Twenty-four transcripts were found in 21 patients. The most common was b2a2, followed by b3a2, b3a3, and e1a3 present solely in 12 (57.1%, 3 (14.3%, 2 (9.5%, and 1 (4.8%, respectively. Three samples (14.3% contained dual transcripts. While b3a2 transcript was apparently associated with warning molecular response to imatinib treatment, b2a2, b3a3, and e1a3 transcripts collectively proved otherwise (P=0.047. Conclusion. It might be advisable to identify the BCR-ABL transcript type in CML patients at diagnosis, using an empirically verified method, in order to link the detected transcript with the clinical findings, possible resistance to treatment, and appropriate monitoring methods.
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Customer benefits and willingness to buy of Samsung Galaxy Gear in the Czech Republic
Hrabě, David
2014-01-01
This bachelor thesis is dedicated to analysis of customer benefits and willingness to buy of Samsung Galaxy Gear in the Czech Republic. The theoretical part includes information needed in relation to the marketing research problem and in the practical part the researcher collects and analyses the information gathered through several research methods. At the end the bachelor thesis, the author tries to explain the main reasons of willingness or unwilligness to buy of Samsung Galaxy Gear in the...
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Gulian, J M; Dalmasso, C; Millet, V; Unal, D; Charrel, M
1995-08-01
We compared data obtained with the Kodak Ektachem and Hitachi 717 Analysers and HPLC from 83 neonates under phototherapy. Total bilirubin values determined with the Kodak and Hitachi are in good agreement, but we observed a large discrepancy in the results for conjugated (Kodak) and direct (Hitachi) bilirubin. HPLC revealed that all the samples contained configurational isomers, while only 7.7% and 30.8% contained conjugated bilirubin and structural isomers, respectively. We developed a device for the specific and quantitative production of configurational or structural isomers, by irradiation with blue or green light. In vitro, total bilirubin values are coherent for the routine analysers in the presence of configurational or structural isomers. With configurational isomers, unconjugated bilirubin (Kodak) is lower than total bilirubin (Kodak), and conjugated bilirubin (Kodak) is always equal to zero, so the apparatus gives a false positive response for delta bilirubin. In contrast, the direct bilirubin (Hitachi) is constant. Furthermore, in the presence of structural isomers, unconjugated bilirubin (Kodak) is unexpectedly higher than total bilirubin (Kodak), conjugated bilirubin (Kodak) is proportional to the quantity of these isomers, and direct bilirubin (Hitachi) is constant. The contribution of photoisomers in bilirubin measurements is discussed.
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The semantics of Chemical Markup Language (CML): dictionaries and conventions
2011-01-01
The semantic architecture of CML consists of conventions, dictionaries and units. The conventions conform to a top-level specification and each convention can constrain compliant documents through machine-processing (validation). Dictionaries conform to a dictionary specification which also imposes machine validation on the dictionaries. Each dictionary can also be used to validate data in a CML document, and provide human-readable descriptions. An additional set of conventions and dictionaries are used to support scientific units. All conventions, dictionaries and dictionary elements are identifiable and addressable through unique URIs. PMID:21999509
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The semantics of Chemical Markup Language (CML): dictionaries and conventions.
Murray-Rust, Peter; Townsend, Joe A; Adams, Sam E; Phadungsukanan, Weerapong; Thomas, Jens
2011-10-14
The semantic architecture of CML consists of conventions, dictionaries and units. The conventions conform to a top-level specification and each convention can constrain compliant documents through machine-processing (validation). Dictionaries conform to a dictionary specification which also imposes machine validation on the dictionaries. Each dictionary can also be used to validate data in a CML document, and provide human-readable descriptions. An additional set of conventions and dictionaries are used to support scientific units. All conventions, dictionaries and dictionary elements are identifiable and addressable through unique URIs.
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Comparison of avian biochemical test results with Abaxis VetScan and Hitachi 911 analyzers.
Greenacre, Cheryl B; Flatland, Bente; Souza, Marcy J; Fry, Michael M
2008-12-01
To compare results of clinical biochemical analysis using an Abaxis VetScan bench-top analyzer with reagents specifically marketed for avian use and a Hitachi 911 analyzer, plasma (both methods) and whole blood (VetScan method) samples from 20 clinically healthy Hispaniolan Amazon parrots (Amazona ventralis) were analyzed. Correlation between methods was very high (r = 0.9-1.0) for aspartate aminotransferase (AST), calcium, glucose, and uric acid; high (r = 0.7-0.89) for creatine kinase (CK), phosphorus, potassium, and total protein; moderate (r = 0.5-0.69) for globulin; and low (r = 0.3-0.49) for albumin and sodium. VetScan analyzer results for globulin, sodium, and uric acid had a constant negative bias (values below those from the Hitachi method). Based on difference plot analysis, results for AST, calcium, CK, and glucose are comparable. Because 16 of 20 values fell below the lower detection limit of the VetScan analyzer, bile acid data were excluded from analysis. By using a relatively small sample size (0.1 ml whole blood or plasma), the VetScan analyzer offers rapid in-house results, compact size, and ease of operation. For 4 of the most clinically relevant biochemical analytes used in avian medicine (AST, calcium, CK, glucose), it offers reliable values. For an additional 4 analytes (phosphorous, potassium, total protein, uric acid), establishing analyzer-specific reference intervals is recommended. Neither the VetScan nor the Hitachi method is recommended to assess albumin and globulin concentrations.
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Payandeh, Mehrdad; Sadeghi, Edris; Khodarahmi, Reza; Sadeghi, Masoud
2014-01-01
Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly (>43 year). However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. In our report, a 52-year-old female was diagnosed with CLL (type of bone marrow (BM) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months after the diagnosis of CLL, she developed CML. She was treated with imatinib (400mg/day). After a fe...
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Management of CML in the Pediatric Age Group: Imatinib Mesylate or SCT.
El-Alfy, Mohsen S; Al-Haddad, Alaa M; Hamed, Ahmed A
2010-12-01
Management of CML has changed markedly since the introduction of tyrosine kinase inhibitors (TKIs). However stem cell transplantation (SCT) remains a valid therapeutic modality especially in developing countries due to its relatively lower cost. We aim to compare between imatinib mesylate and SCT as regard outcome in CML in the pediatric age group. Forty-eight patients with newly diagnosed CML in the chronic phase, aged 3 to 18 years were enrolled in this prospective study. Patients without a matched donor (Group I; N=30) were assigned to receive imatinib mesylate at a dose of 340mg÷m2÷day, while patients with a fully matched related donor (Group II; N=18), were offered SCT. Response (hematologic, cytogenetic and molecular), side effects and survival were analyzed. Complete hematologic response was obtained in 97% of the patients in group I and 94% in group II. Major cytogenetic response (CyR) was obtained in 80% of patients in group I and 100% in group II. Complete CyR was 57% in group I and 64% in group II. Major molecular response (MMR) was 36% in group I and 50% in group II with no significant difference between both groups. Six years overall survival (OS) was 87% in the 1st group and 61% in the 2nd group (pSCT group (55% had GVHD and 78% had infection). Imatinib mesylate has a superior OS and EFS than SCT in children. It is generally safe and well tolerated. Imatinib mesylate should be the 1st line treatment of pediatric patients with CML in the chronic phase. CML- Imatinib- SCT- Pediatrics.
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Ramos, Teresa L; Sánchez-Abarca, Luis Ignacio; López-Ruano, Guillermo; Muntión, Sandra; Preciado, Silvia; Hernández-Ruano, Montserrat; Rosado, Belén; de las Heras, Natalia; Chillón, M Carmen; Hernández-Hernández, Ángel; González, Marcos; Sánchez-Guijo, Fermín; Del Cañizo, Consuelo
2015-08-01
The expression of BCR-ABL in hematopoietic stem cells is a well-defined primary event in chronic myeloid leukemia (CML). Some reports have described the presence of BCR-ABL on endothelial cells from CML patients, suggesting the origin of the disease in a primitive hemangioblastic cell. On the other hand, extracellular vesicles (EVs) released by CML leukemic cells are involved in the angiogenesis modulation process. In the current work we hypothesized that EVs released from BCR-ABL(+) cells may carry inside the oncogene that can be transferred to endothelial cells leading to the expression of both BCR-ABL transcript and the oncoprotein. EVs from K562 cells and plasma of newly diagnosed CML patients were isolated by ultracentrifugation. RT-PCR analysis detected the presence of BCR-ABL RNA in the EVs isolated from both K562 cells and plasma of CML patients. The incorporation of these EVs into endothelial cells was demonstrated by flow cytometry and fluorescence microscopy showed that after 24h of incubation most EVs were incorporated. BCR-ABL transcripts were detected in all experiments on endothelial cells incubated with EVs from both sources. The presence of BCR-ABL on endothelial cells incubated with Philadelphia(+) EVs was also confirmed by Western blot assays. In summary, endothelial cells acquire BCR-ABL RNA and the oncoprotein after incubation with EVs released from Ph(+) positive cells (either from K562 cells or from plasma of newly diagnosed CML patients). This results challenge the hypothesis that endothelial cells may be part of the Philadelphia(+) clone in CML. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Wambui, Elizabeth
2013-01-01
This thesis research is going to analyze the marketing strategy Samsung has used for some of its smartphone devices in the Smartphone market. The thesis will look into products introduced within the last two years. This approach seems reasonable due to the rapid change of technology in high tech market and continuous introduction of new innovative products within a short period of time. The research will start by understanding the mission and goals of the company. Then it will continue in exp...
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Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression.
Negi, Vijay; Vishwakarma, Bandana A; Chu, Su; Oakley, Kevin; Han, Yufen; Bhatia, Ravi; Du, Yang
2017-11-17
Mechanisms underlying the progression of Chronic Myeloid Leukemia (CML) from chronic phase to myeloid blast crisis are poorly understood. Our previous studies have suggested that overexpression of SETBP1 can drive this progression by conferring unlimited self-renewal capability to granulocyte macrophage progenitors (GMPs). Here we show that overexpression of Hoxa9 or Hoxa10 , both transcriptional targets of Setbp1 , is also sufficient to induce self-renewal of primary myeloid progenitors, causing their immortalization in culture. More importantly, both are able to cooperate with BCR/ABL to consistently induce transformation of mouse GMPs and development of aggressive leukemias resembling CML myeloid blast crisis, suggesting that either gene can drive CML progression by promoting the self-renewal of GMPs. We further identify Myb as a common critical target for Hoxa9 and Hoxa10 in inducing self-renewal of myeloid progenitors as Myb knockdown significantly reduced colony-forming potential of myeloid progenitors immortalized by the expression of either gene. Interestingly, Myb is also capable of immortalizing primary myeloid progenitors in culture and cooperating with BCR/ABL to induce leukemic transformation of mouse GMPs. Significantly increased levels of MYB transcript also were detected in all human CML blast crisis samples examined over chronic phase samples, further suggesting the possibility that MYB overexpression may play a prevalent role in driving human CML myeloid blast crisis development. In summary, our results identify overexpression of HOXA9 , HOXA10 , and MYB as critical drivers of CML progression, and suggest MYB as a key therapeutic target for inhibiting the self-renewal of leukemia-initiating cells in CML myeloid blast crisis patients.
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2012-03-13
... Laser Enrichment LLC, Commercial Laser-Based Uranium Enrichment Facility, Wilmington, North Carolina... a license to General Electric-Hitachi Global Laser Enrichment LLC (GLE or the applicant) to authorize construction of a laser-based uranium enrichment facility and possession and use of byproduct...
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Hughes, Bill
2013-01-01
Explore a world of possibilities with your Samsung Galaxy S 4 smartphone Everything's more exciting when you've got the Galaxy in your hand. Let For Dummies be your guide to getting the most out of your Galaxy S 4. You'll cruise through the smartphone basics and set up process before moving on to the fun stuff like staying in touch with e-mail and texting, surfing the web, navigating with maps, shooting and sharing photos and video, watching movies, listening to music, and so much more. Whether you're entering the smartphone world for the first time or just moving up to
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Samsung Galaxy Tab S for dummies
Gookin, Dan
2015-01-01
Explore your Galaxy Tab S with an expert tour guide at your side Samsung Galaxy Tab S For Dummies is a user-friendly guide to getting the most out of your new tablet. You'll discover how different the tablet experience is from the desktop, laptop, or smartphone, and learn how to take advantage of everything your Galaxy Tab S has to offer. This entertaining guide walks you through each feature one by one, helping you learn exactly what your tablet can do for you. With everything from reading to playing games and surfing the Internet, you will learn how to be productive and have fun, too! Nav
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GE-Hitachi ABWR Design for 60 Years of Operation
International Nuclear Information System (INIS)
Hoang Xuan Hoa
2011-01-01
The GE Hitachi ABWR design benefits from the experiences of the prior generation BWRs in operation since the 1970s, and the knowledge learned from years of technical research on the aging effects on reactor systems, structures and components. The impact of exposure to neutrons over time to the reactor pressure vessel and internal components was evaluated to confirm their structural integrity. Other time-based plant analyses, such as fatigue vibration and corrosion effect, have also been performed on the ABWR to support a 60-year plant life assumption. Finally, operating experience and aging lessons learned have been used to verify the maintenance plans for plant aging management are acceptable to support operation up to 60 years. (author)
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Diagnosis and Treatment of Chronic Myeloid Leukemia (CML) in 2015
Thompson, Philip A; Kantarjian, Hagop; Cortes, Jorge E
2017-01-01
Few neoplastic diseases have undergone a transformation in a relatively short period of time like chronic myeloid leukemia (CML) has in the last few years. In 1960, CML was the first cancer where a unique chromosomal abnormality, “a minute chromosome”,1 was identified and a pathophysiologic correlation suggested. Landmark work followed, recognizing the underlying translocation between chromosomes 9 and 22 that gave rise to this abnormality2 and shortly afterward, the specific genes involved3,4 and the pathophysiologic implications of this novel rearrangement.5–7 Fast-forward a few years, this knowledge has given us the most remarkable example of a specific therapy targeting the dysregulated kinase activity represented by this molecular change. The broad use of tyrosine kinase inhibitors has resulted in an improvement in the overall survival to the point where the life expectancy of patients today is nearly equal to that of the general population.8 Still, there are challenges and unanswered questions that define the reasons why the progress still escapes many patients, and the details that separate patients from ultimate “cure”. In this manuscript we review our current understanding of CML in 2015, present recommendations for optimal management, and discuss the unanswered questions and what could be done to answer them in the near future. PMID:26434969
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Technical knowledge/skill transfer in nuclear division of Hitachi group
International Nuclear Information System (INIS)
Arima, Hiroshi
2008-01-01
Due to environmental concerns such as global warming, needs the nuclear power is increasing. However, many expert engineers and technicians are now entering a period of retirement. And due to weak demands of new plant construction for long years, opportunity for technology learning/experience had been lost. Therefore, to secure human resource and to develop their ability are urgent issues for nuclear industries. Hitachi nuclear division continues efforts for technology transfer and human resource training. This paper describes the following two activities. (1) Improvement of common technical basis, and implementation of PDCA cycle. (2) Development of supporting tools to accelerate technology transfer through OJT (On the Job Training). (author)
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GE Nuclear Hitachi Energy is prepared for the nuclear Renaissance
International Nuclear Information System (INIS)
Carelli, J. M.
2008-01-01
GE Hitachi Nuclear Energy (GEH) is offering two technologies to meet the needs of utilities planning new nuclear projects. An aging workforce, new technological developments and forecasts of considerable new construction projects, raise questions for the entire industry regarding our human resources. In order to prepare for the coming resurgence in new nuclear projects, GEH taking positive action to ensure that adequate human resources are available. From early learning programs that encourage young students to pursue careers in science and technology, to hands-on vocational and engineering programs, GEH works with communities and young people to recruit and train the workforce that will enable our success. (Author)
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Retail marketing a in-store promotion společnosti Samsung Electronics Czech and Slovak s.r.o.
Košťál, Michal
2015-01-01
This thesis deals with the retail marketing and the in-store promotion. It is prima-rily focused on merchandising, sales promotion and other selected activities. The work itself is devoted to Samsung Electronics Czech and Slovak s.r.o. and is mostly based on a practical experience gained from a position of an employee. Firstly, the amount of investments in marketing of Samsung in comparison with the competition is introduced. The following part describes the basic retail acti-vities across th...
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Beckers, Niek; Schreiner, Sam; Bertrand, Pierre; Mehler, Bruce; Reimer, Bryan
2017-01-01
The relative impact of using a Google Glass based voice interface to enter a destination address compared to voice and touch-entry methods using a handheld Samsung Galaxy S4 smartphone was assessed in a driving simulator. Voice entry (Google Glass and Samsung) had lower subjective workload ratings, lower standard deviation of lateral lane position, shorter task durations, faster remote Detection Response Task (DRT) reaction times, lower DRT miss rates, and resulted in less time glancing off-road than the primary visual-manual interaction with the Samsung Touch interface. Comparing voice entry methods, using Google Glass took less time, while glance metrics and reaction time to DRT events responded to were similar. In contrast, DRT miss rate was higher for Google Glass, suggesting that drivers may be under increased distraction levels but for a shorter period of time; whether one or the other equates to an overall safer driving experience is an open question. Copyright © 2016 Elsevier Ltd. All rights reserved.
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2010-01-13
... Energy Americas LLC (GEH), which is a wholly owned subsidiary of GE-Hitachi Nuclear Energy Holdings LLC..., 2009, the NRC published notice of its intent to prepare an Environmental Impact Statement (EIS) on the... on the issuance of a license is completed. See Notice of Intent to Prepare an Environmental Impact...
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Directory of Open Access Journals (Sweden)
Williams Jonathan
2007-10-01
Full Text Available Abstract Background Advanced glycation end-products (AGEs and their receptor (RAGE occur in dementia of the Alzheimer's type and diabetic microvascular disease. Accumulation of AGEs relates to risk factors for vascular dementia with ageing, including hypertension and diabetes. Cognitive dysfunction in vascular dementia may relate to microvascular disease resembling that in diabetes. We tested if, among people with cerebrovascular disease, (1 those with dementia have higher levels of neuronal and vascular AGEs and (2 if cognitive dysfunction depends on neuronal and/or vascular AGE levels. Methods Brain Sections from 25 cases of the OPTIMA (Oxford Project to Investigate Memory and Ageing cohort, with varying degrees of cerebrovascular pathology and cognitive dysfunction (but only minimal Alzheimer type pathology were immunostained for Nε-(carboxymethyl-lysine (CML, the most abundant AGE. The level of staining in vessels and neurons in the cortex, white matter and basal ganglia was compared to neuropsychological and other clinical measures. Results The probability of cortical neurons staining positive for CML was higher in cases with worse cognition (p = 0.01 or a history of hypertension (p = 0.028. Additionally, vascular CML staining related to cognitive impairment (p = 0.02 and a history of diabetes (p = 0.007. Neuronal CML staining in the basal ganglia related to a history of hypertension (p = 0.002. Conclusion CML staining in cortical neurons and cerebral vessels is related to the severity of cognitive impairment in people with cerebrovascular disease and only minimal Alzheimer pathology. These findings support the possibility that cerebral accumulation of AGEs may contribute to dementia in people with cerebrovascular disease.
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TRACG: Twenty years of collaboration between ENUSA and GE-HITACHI
International Nuclear Information System (INIS)
Haces, J.; Trueba, M.; Garcia, J.; Barrera, J.
2011-01-01
TRACG is the GE Hitachi Nuclear Energy (GEH) proprietary version of the Transient Reactor Analysis Code. It is a best-estimate code for analysis of boiling eater reactors (BWR). Enusa has extensively contributed to the development of TRACG, applying this code to different scenarios and BWR plants: loss-of-coolant accident (LOCA), anticipated operational occurrences (AOO), instability events licensing of GNF fuel for Nordic plants, anticipated transients without scram (ATWS) reactivity insertion accidents (RIA), validation of the simulator for the Advanced BWR (ABWR) plant, the licensing of the TRACG based U. s. Nuclear Regulatory commission (NRC)-approved AOO and LOCA licensing methodologies, and in the licensing of the passively safe generation III+ Economic Simplified Boiling Water Reactor (ESBWR).
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Coupled map lattice (CML) approach to power reactor dynamics (I) - preservation of normality
International Nuclear Information System (INIS)
Konno, H.
1996-01-01
An application of coupled map lattice (CML) model for simulating power fluctuations in nuclear power reactors is presented. (1) Preservation of Gaussianity in the point model is studied in a chaotic force driven Langevin equation in conjunction with the Gaussian-white noise driven Langevin equation. (2) Preservation of Guassianity is also studied in the space-dependent model with the use of a CML model near the onset of the Hopf bifurcation point. It is shown that the spatial dimensionality decreases as the maximum eigenvalue of the system increases. The result is consistent with the observation of neutron fluctuation in a BWR. (author)
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Li, Fengyin; He, Bing; Ma, Xiaoke; Yu, Shuyang; Bhave, Rupali R; Lentz, Steven R; Tan, Kai; Guzman, Monica L; Zhao, Chen; Xue, Hai-Hui
2017-09-07
Effective treatment of chronic myelogenous leukemia (CML) largely depends on the eradication of CML leukemic stem cells (LSCs). We recently showed that CML LSCs depend on Tcf1 and Lef1 factors for self-renewal. Using a connectivity map, we identified prostaglandin E1 (PGE1) as a small molecule that partly elicited the gene expression changes in LSCs caused by Tcf1/Lef1 deficiency. Although it has little impact on normal hematopoiesis, we found that PGE1 treatment impaired the persistence and activity of LSCs in a pre-clinical murine CML model and a xenograft model of transplanted CML patient CD34 + stem/progenitor cells. Mechanistically, PGE1 acted on the EP4 receptor and repressed Fosb and Fos AP-1 factors in a β-catenin-independent manner. Misoprostol, an FDA-approved EP4 agonist, conferred similar protection against CML. These findings suggest that activation of this PGE1-EP4 pathway specifically targets CML LSCs and that the combination of PGE1/misoprostol with conventional tyrosine-kinase inhibitors could provide effective therapy for CML. Copyright © 2017 Elsevier Inc. All rights reserved.
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PC data station for Hitachi F-2000 spectrofluorimeter
International Nuclear Information System (INIS)
Yakub Ali, Mohd; Dhoble, A.R.; Jadhav, R.T.; Godbole, S.V.
2004-01-01
The paper describes the PC based data station for stand-alone HIT ACHI F-2000 Spectrofluorimeter, for data acquisition, storage and analysis. The hardware link between the instrument and PC is made through RS232 serial port. The state of art software for control and data management is designed, developed and implemented in Visual Basic (Version 6). The software features on-screen editing of all operation parameters of the instrument and the operational control is achieved by Visual Basic command words communicated through serial port. Using this system, in addition to acquiring and storage of spectral data, it was possible to obtain the normalized absorption spectra of the samples. PC adapted Hitachi F-2000 Spectrofluorimeter can be successfully used for various operations such as photometric detection of UO22+ ions, recording of emission and excitation spectra and time evolution of fluorescence intensity on continuous UV irradiation. The data storage achieved through PC adaptation has also enabled recording of absorption spectra. (author)
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Woessner, David W.; Lim, Carol S.
2012-01-01
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell.1 Therapeutic management of CML uses tyrosine kinase inhibitors (TKIs), which blocks ABL-signaling and effectively kill peripheral cells with BCR-ABL. However, TKIs are not curative, and chronic use of is required in order to treat CML. The primary failure for TKIs is through development of a resistant population d...
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The semantics of Chemical Markup Language (CML for computational chemistry : CompChem
Directory of Open Access Journals (Sweden)
Phadungsukanan Weerapong
2012-08-01
Full Text Available Abstract This paper introduces a subdomain chemistry format for storing computational chemistry data called CompChem. It has been developed based on the design, concepts and methodologies of Chemical Markup Language (CML by adding computational chemistry semantics on top of the CML Schema. The format allows a wide range of ab initio quantum chemistry calculations of individual molecules to be stored. These calculations include, for example, single point energy calculation, molecular geometry optimization, and vibrational frequency analysis. The paper also describes the supporting infrastructure, such as processing software, dictionaries, validation tools and database repositories. In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed. The uses of CompChem are illustrated by two practical applications.
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The semantics of Chemical Markup Language (CML) for computational chemistry : CompChem.
Phadungsukanan, Weerapong; Kraft, Markus; Townsend, Joe A; Murray-Rust, Peter
2012-08-07
: This paper introduces a subdomain chemistry format for storing computational chemistry data called CompChem. It has been developed based on the design, concepts and methodologies of Chemical Markup Language (CML) by adding computational chemistry semantics on top of the CML Schema. The format allows a wide range of ab initio quantum chemistry calculations of individual molecules to be stored. These calculations include, for example, single point energy calculation, molecular geometry optimization, and vibrational frequency analysis. The paper also describes the supporting infrastructure, such as processing software, dictionaries, validation tools and database repositories. In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed. The uses of CompChem are illustrated by two practical applications.
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Performance and Safety Tests on Samsung 18650 Li-ion Cells with Two Capacities
Deng, Yi; Jeevarajan, Judith; Rehm, Raymond; Bragg, Bobby; Zhang, Wenlin
2001-01-01
In order to meet the applications for Space Shuttle in the future, Samsung 18650 cylindrical Li-ion cells with two different capacities have been evaluated. The capacities are 1800 mAh, and 2000 mAh. The studies focused on the performance and safety tests of the cells.
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Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML
D. van der Plas (D.); G.C. Grosveld (Gerard); A. Hagemeijer (Anne)
1991-01-01
markdownabstractAbstract Between 1985 and 1989, many cases of Philadelphia (Ph) chromosome negative chronic myelogenous leukemia (CML) were reported. For this review, the following selection criteria were used: the original articles on Ph-negative cases should provide clinical, hematologic,
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Tarigan, Azalea Azura
2015-01-01
This research is to study and analyze bertujuuan Lifestyle (X1), price (X2), and the Reference Group (X3) on Purchase Decision Samsung Smartphone the Student Faculty of Economics and Business University Of North Sumatera. The sampling technique using puposive Sampling, which samples were selected based on specific criteria. The population in this study were students of the Faculty of Economics and Business University of North Sumatra active college which has used Samsung Smartphone of the yea...
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Directory of Open Access Journals (Sweden)
Sungchul Choi
2016-12-01
Full Text Available The aim of this paper is to propose a method to investigate a firm’s strategic changes. Technologies or technological capabilities are a major resource for achieving competitive advantages, so a firm’s R&D effort to improve capabilities on specific technologies is aligned with strategic direction. Therefore, this research analyzes changes in R&D efforts by identifying key R&D personnel using patent co-inventor network and social network analysis. Based on characteristics of application and granted patents, the method analyzes current and future R&D efforts and so identifies strategic changes of a firm. We conducted an empirical analysis using the patents of Samsung Electronics. Our method analyzed the current and future strategies of Samsung Electronics and the result shows clear strategic changes in their focal technologies and business.
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Directory of Open Access Journals (Sweden)
Ihnji Jon
2016-11-01
Full Text Available This study examines people’s response actions in the first 30 min after shaking stopped following earthquakes in Christchurch and Wellington, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch, 332 respondents in Hitachi, and 204 respondents in Wellington revealed notable similarities in some response actions immediately after the shaking stopped. In all four events, people were most likely to contact family members and seek additional information about the situation. However, there were notable differences among events in the frequency of resuming previous activities. Actions taken in the first 30 min were weakly related to: demographic variables, earthquake experience, contextual variables, and actions taken during the shaking, but were significantly related to perceived shaking intensity, risk perception and affective responses to the shaking, and damage/infrastructure disruption. These results have important implications for future research and practice because they identify promising avenues for emergency managers to communicate seismic risks and appropriate responses to risk area populations.
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Directory of Open Access Journals (Sweden)
Guillaume Robert
Full Text Available CML is an hematopoietic stem cell disease characterized by the t(9;22 (q34;q11 translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL was investigated in different CML cell lines. Acadesine triggered loss of cell metabolism in K562, LAMA-84 and JURL-MK1 and was also effective in killing imatinib-resistant K562 cells and Ba/F3 cells carrying the T315I-BCR-ABL mutation. The anti-leukemic effect of acadesine did not involve apoptosis but required rather induction of autophagic cell death. AMPK knock-down by Sh-RNA failed to prevent the effect of acadesine, indicating an AMPK-independent mechanism. The effect of acadesine was abrogated by GF109203X and Ro-32-0432, both inhibitor of classical and new PKCs and accordingly, acadesine triggered relocation and activation of several PKC isoforms in K562 cells. In addition, this compound exhibited a potent anti-leukemic effect in clonogenic assays of CML cells in methyl cellulose and in a xenograft model of K562 cells in nude mice. In conclusion, our work identifies an original and unexpected mechanism by which acadesine triggers autophagic cell death through PKC activation. Therefore, in addition to its promising effects in B-CLL, acadesine might also be beneficial for Imatinib-resistant CML patients.
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2010-01-01
... 7 Agriculture 3 2010-01-01 2010-01-01 false Lamb. 65.190 Section 65.190 Agriculture Regulations of..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.190 Lamb. Lamb means meat produced from sheep. ...
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Directory of Open Access Journals (Sweden)
Giallongo Cesarina
2013-02-01
Full Text Available Abstract Background SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as a tumor suppressor or promoter, depending on its different functions in the tumor microenvironment. In this study we investigated the variations in SPARC production by peripheral blood cells from chronic myeloid leukemia (CML patients at diagnosis and after treatment and we identified the subpopulation of cells that are the prevalent source of SPARC. Methods We evaluated SPARC expression using real-time PCR and western blotting. SPARC serum levels were detected by ELISA assay. Finally we analyzed the interaction between exogenous SPARC and imatinib (IM, in vitro, using ATP-lite and cell cycle analysis. Results Our study shows that the CML cells of patients at diagnosis have a low mRNA and protein expression of SPARC. Low serum levels of this protein are also recorded in CML patients at diagnosis. However, after IM treatment we observed an increase of SPARC mRNA, protein, and serum level in the peripheral blood of these patients that had already started at 3 months and was maintained for at least the 18 months of observation. This SPARC increase was predominantly due to monocyte production. In addition, exogenous SPARC protein reduced the growth of K562 cell line and synergized in vitro with IM by inhibiting cell cycle progression from G1 to S phase. Conclusion Our results suggest that low endogenous SPARC expression is a constant feature of BCR/ABL positive cells and that IM treatment induces SPARC overproduction by normal cells. This exogenous SPARC may inhibit CML cell proliferation and may synergize with IM activity against CML.
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International Nuclear Information System (INIS)
Giallongo, Cesarina; Palumbo, Giuseppe A; Di Raimondo, Francesco; La Cava, Piera; Tibullo, Daniele; Barbagallo, Ignazio; Parrinello, Nunziatina; Cupri, Alessandra; Stagno, Fabio; Consoli, Carla; Chiarenza, Annalisa
2013-01-01
SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as a tumor suppressor or promoter, depending on its different functions in the tumor microenvironment. In this study we investigated the variations in SPARC production by peripheral blood cells from chronic myeloid leukemia (CML) patients at diagnosis and after treatment and we identified the subpopulation of cells that are the prevalent source of SPARC. We evaluated SPARC expression using real-time PCR and western blotting. SPARC serum levels were detected by ELISA assay. Finally we analyzed the interaction between exogenous SPARC and imatinib (IM), in vitro, using ATP-lite and cell cycle analysis. Our study shows that the CML cells of patients at diagnosis have a low mRNA and protein expression of SPARC. Low serum levels of this protein are also recorded in CML patients at diagnosis. However, after IM treatment we observed an increase of SPARC mRNA, protein, and serum level in the peripheral blood of these patients that had already started at 3 months and was maintained for at least the 18 months of observation. This SPARC increase was predominantly due to monocyte production. In addition, exogenous SPARC protein reduced the growth of K562 cell line and synergized in vitro with IM by inhibiting cell cycle progression from G1 to S phase. Our results suggest that low endogenous SPARC expression is a constant feature of BCR/ABL positive cells and that IM treatment induces SPARC overproduction by normal cells. This exogenous SPARC may inhibit CML cell proliferation and may synergize with IM activity against CML
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Plasma discharge in ferritic first wall vacuum vessel of the Hitachi Tokamak HT-2
International Nuclear Information System (INIS)
Abe, Mitsushi; Nakayama, Takeshi; Asano, Katsuhiko; Otsuka, Michio
1997-01-01
A tokamak discharge with ferritic material first wall was tried successfully. The Hitachi Tokamak HT-2 had a stainless steel SUS304 vacuum vessel and modified to have a ferritic plate first wall for experiments to investigate the possibility of ferritic material usage in magnetic fusion devices. The achieved vacuum pressure and times used for discharge cleaning was roughly identical with the stainless steel first wall or the original HT-2. We concluded that ferritic material vacuum vessel is possible for tokamaks. (author)
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Design and prototyping of real-time systems using CSP and CML
DEFF Research Database (Denmark)
Rischel, Hans; Sun, Hong Yan
1997-01-01
A procedure for systematic design of event based systems is introduced by means of the Production Cell case study. The design is documented by CSP style processes, which allow both verification using formal techniques and also validation of a rapid prototype in the functional language CML...
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2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Facilities. 1271.190 Section 1271.190 Food and... CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.190 Facilities. (a) General. Any facility used in the manufacture of HCT/Ps must be of suitable size, construction, and location to prevent...
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International Nuclear Information System (INIS)
Leitao, Catarine Canellas Gondim
2005-04-01
In this work, trace elements were analyzed in serum of patients with chronic myelogenous leukemia (CML) by Total Reflection X-Ray Fluorescence using synchrotron radiation (SRTXRF). Chronic myelogenous leukemia (CML) affects the myeloid cells in the blood and affects 1 to 2 people per 100,000 and accounts for 7-20% cases of leukemia. Sixty patients with CML and sixty healthy volunteers (control group) were studied. Blood was collected into vacutainers without additives. Directly after collection, each blood sample was centrifuged at 3000 rev/min for 10 min in order to separate blood cells and suspended particles from blood serum. Sera were transferred into polyethylene tubes and stored in a freezer at 253 K. A 500 m u L serum quantity was spiked with Ga (50 m u L ) as internal standard. 10 m u L aliquots were pipetted on Perspex sample carrier. After deposition, the samples were left to dry under an infrared lamp. The measurements were performed at the X-Ray Fluorescence Beamline at Brazilian National Synchrotron Light Laboratory (LNLS), using a polychromatic beam. Standard solutions with gallium as internal standard were prepared for calibration system. It was possible to determine the concentrations of the following elements: P, S, Cl, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Br and Rb. Starting from the ANOVA test was observed that the elements P, S, Ca, Cr, Mn, Fe, Cu and Rb presented real significant differences (α = 0.05) between groups (healthy subjects and CML patients) and Sex (males and females). (author)
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“Preleukemic or smoldering” chronic myelogenous leukemia (CML:BCR-ABL1 positive: A brief case report
Directory of Open Access Journals (Sweden)
John M. Bennett
2015-01-01
The most common feature of CML is an elevated WBC count, usually above 25×103/µL, and frequently above 100×103/µL. We report a case of confirmed Ph+CML with a normal CBC detected because of the presence of rare myelocytes and 2% basophils [Fig. 1]. Previous leukocyte counts for the preceding eight years were normal with the exception of one done four months prior to his presentation that showed an abnormal differential with 1% basophils, 2% metamyelocytes and 2% myelocytes.
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Analysis list: Cp190 [Chip-atlas[Archive
Lifescience Database Archive (English)
Full Text Available Cp190 Cell line,Embryo,Larvae + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/...target/Cp190.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Cp190.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/target/Cp190.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Cp190.Cell_l...ine.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Cp190.Embryo.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cp190.Larvae.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/
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Chromosome abnormalities in the acute phase of CML
Energy Technology Data Exchange (ETDEWEB)
Rowley, J D
1978-01-01
Additional chromosome changes are superimposed on the Ph/sup 1/ positive cell line in approximately 80% of patients in the acute phase of chronic myelogenous leukemia (CML). These changes may precede the onset of blast crisis by several months. They are nonrandom and frequently involve an extra No. 8, an isochromosome for the long arm of No. 17, an extra No. 19, and a second Ph/sup 1/ chromosome. Since such changes may occur in combination, modal numbers frequently range between 47 and 57 chromosomes. Although present evidence suggests that abnormal clones originate, or at least proliferate, in the spleen, similar changes have been observed in patients who underwent splenectomy during the chronic phase of their disease. The question of particular clinical-chromosomal correlations has been discussed in only one study. It appeared that patients whose karyotype did not change might have a longer median survival than those whose karyotype showed additional abnormalities. Tests for levels of terminal deoxynucleotidyl transferase (TDT) and response to anti-acute lymphoblastic leukemia (ALL) serum suggest that some, but not all patients react as do patients with ALL. Those who are similar to ALL have high levels of TDT and are anti-ALL serum-positive; the others have low levels of TDT and are anti-ALL serum-negative. In the future, correlations of these more sophisticated tests with the blast morphology, clinical course, and karyotype pattern should provide significant new insights into the acute phase of CML.
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International Nuclear Information System (INIS)
Podzelinska, K.; Latimer, R.; Bhattacharya, A.; Vining, L.; Zechel, D.; Jia, Z.
2010-01-01
Chloramphenicol is a halogenated natural product bearing an unusual dichloroacetyl moiety that is critical for its antibiotic activity. The operon for chloramphenicol biosynthesis in Streptomyces venezuelae encodes the chloramphenicol halogenase CmlS, which belongs to the large and diverse family of flavin-dependent halogenases (FDH's). CmlS was previously shown to be essential for the formation of the dichloroacetyl group. Here we report the X-ray crystal structure of CmlS determined at 2.2 (angstrom) resolution, revealing a flavin monooxygenase domain shared by all FDHs, but also a unique 'winged-helix' C-terminal domain that creates a T-shaped tunnel leading to the halogenation active site. Intriguingly, the C-terminal tail of this domain blocks access to the halogenation active site, suggesting a structurally dynamic role during catalysis. The halogenation active site is notably nonpolar and shares nearly identical residues with Chondromyces crocatus tyrosyl halogenase (CndH), including the conserved Lys (K71) that forms the reactive chloramine intermediate. The exception is Y350, which could be used to stabilize enolate formation during substrate halogenation. The strictly conserved residue E44, located near the isoalloxazine ring of the bound flavin adenine dinucleotide (FAD) cofactor, is optimally positioned to function as a remote general acid, through a water-mediated proton relay, which could accelerate the reaction of the chloramine intermediate during substrate halogenation, or the oxidation of chloride by the FAD(C4α)-OOH intermediate. Strikingly, the 8α carbon of the FAD cofactor is observed to be covalently attached to D277 of CmlS, a residue that is highly conserved in the FDH family. In addition to representing a new type of flavin modification, this has intriguing implications for the mechanism of FDHs. Based on the crystal structure and in analogy to known halogenases, we propose a reaction mechanism for CmlS.
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Directory of Open Access Journals (Sweden)
Alice Charwudzi
2014-01-01
Full Text Available Background. FISH is a molecular cytogenetic technique enabling rapid detection of genetic abnormalities. Facilities that can run fresh/wet samples for molecular diagnosis and monitoring of neoplastic disorders are not readily available in Ghana and other neighbouring countries. This study aims to demonstrate that interphase FISH can successfully be applied to archival methanol-fixed bone marrow and peripheral blood smear slides transported to a more equipped facility for molecular diagnosis of CML. Methods. Interphase FISH was performed on 22 archival methanol-fixed marrow (BM and 3 peripheral blood (PB smear slides obtained at diagnosis. The BM smears included 20 CML and 2 CMML cases diagnosed by morphology; the 3 PB smears were from 3 of the CML patients at the time of diagnosis. Six cases had known BCR-ABL fusion results at diagnosis by RQ-PCR. Full blood count reports at diagnosis were also retrieved. Result. 19 (95% of the CML marrow smears demonstrated the BCR-ABL translocation. There was a significant correlation between the BCR-ABL transcript detected at diagnosis by RQ-PCR and that retrospectively detected by FISH from the aged BM smears at diagnosis (r=0.870; P=0.035. Conclusion. Archival methanol-fixed marrow and peripheral blood smears can be used to detect the BCR-ABL transcript for CML diagnosis.
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Iriyama, Noriyoshi; Ohashi, Kazuteru; Hashino, Satoshi; Kimura, Shinya; Nakaseko, Chiaki; Takano, Hina; Hino, Masayuki; Uchiyama, Michihiro; Morita, Satoshi; Sakamoto, Junichi; Sakamaki, Hisashi; Inokuchi, Koiti
2017-01-01
Objective The aim of this study was to prospectively investigate the efficacy and safety profiles of low-dose dasatinib therapy (50 mg once daily). Methods Patients with chronic myeloid leukemia in the chronic phase (CML-CP) who were being treated with low-dose imatinib (≤200 mg/day), but were resistant to this agent were enrolled in the current study (referred to as the LD-CML study). Results There subjects included 9 patients (4 men and 5 women); all were treated with dasatinib at a dose of 50 mg once daily. Among 8 patients who had not experienced major molecular response (MMR; BCR-ABL1 transcript ≤0.1% according to International Scale [IS]) at study enrollment, 5 attained MMR by 12 months. In particular, 3 of 9 patients demonstrated a deep molecular response (DMR; IS ≤0.0069%) by 18 months. Five patients developed lymphocytosis accompanied by cytotoxic lymphocyte predominance. There was no mortality or disease progression, and all continue to receive dasatinib therapy at 18 months with only 2 patients requiring dose reduction. Toxicities were mild-to-moderate, and pleural effusion was observed in 1 patient (grade 1). Conclusion Low-dose dasatinib can attain MMR and DMR without severe toxicity in patients with CML-CP who are unable to achieve MMR with low-dose imatinib. Switching to low-dose dasatinib should therefore be considered for patients in this setting, especially if they are otherwise considering a cessation of treatment. PMID:29033428
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Recent development of the Cu/Nb-Ti superconducting cables for SSC in Hitachi Cable, Ltd
International Nuclear Information System (INIS)
Sakai, S.; Iwaki, G.; Sawada, Y.; Moriai, H.; Ishigami, Y.
1989-01-01
In these few years, Cu/Nb-Ti superconducting cables for the dipole magnets of SSC projects have been developed in the industrial scale in Hitachi Cable, Ltd. The features of these developed conductors are as follows. (1) The diameter of Nb-Ti filaments is very small, 4-6 μm. (2) The critical current density (J c ) is very high, 2,850-3,050 A/mm 2 at 5 T on wires, 2750-2950 A/mm 2 at 5 T on cables in industrial scale. The champion J c of wires is 3,460 A/mm 2 at 5 T in the laboratory scale. (3) The RRR Residual Resistivity Ratio values of developed cables is very high, approximately 200, due to the newly developed high purity Oxygen Free Copper (OFC). (4) The conductors have been wound to the 1 m length dipole magnet in Hitachi Ltd., and it has generated 6.7 T in the central magnetic field at 6,595 A. The Cu/Cu-Mn/Nb-Ti composite wires which avoid the possibility of electrical coupling of the filaments have been produced in laboratory scale. The RRR of the copper stabilizer and J c properties have not degraded because of no metallurgical reactions between Cu and Mn, Nb-Ti and Mn. 7 refs., 9 figs., 4 tabs
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DEFF Research Database (Denmark)
Dreyer, Louise Camilla; Niemann, Anne Louise; Hauschild, Michael Zwicky
2003-01-01
?’ To investigate this issue, a comparison is performed of three frequently applied life cycle impact assessment methods. Methods. The three life cycle impact assessment methods EDIP97 (1), CML2001 (2) and Eco-indicator 99 (3) are compared on their performance through application to the same life cycle inventory...... of the EDIP97 and CML2001 output, differences up to two orders of magnitude are found for some of the indicator results for the impact categories describing toxicity to humans and ecosystems, and there is little similarity in the patterns of major contributors among the two methods. For human toxicity the CML......2001 score is dominated by contribution from metals while the EDIP97 score is caused by a solvent and nitrogen oxides. For aquatic ecotoxicity, metals are the main contributors for both methods but while it is vanadium for CML2001, it is strontium for EDIP97. After normalisation, the differences...
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Energy Technology Data Exchange (ETDEWEB)
Miras, H.; Perez, M. A.; Macias, J.; Moreno, J. C.; Campo, J. L.; Ortiz, M.; Arrans, R.; Ortiz, A.; Terron, J. A.; Fernandez, D.
2011-07-01
The treatments of intensity modulated radiotherapy (IMRT) require a deep knowledge of the accuracy, precision and reproducibility of positioning of the plates that make up the multi leaf collimator (MLC). We have developed a computer application, 3CML, to analyze an image corresponding to a pattern of separate bands irradiation to determine the deviations of the positioning of the blades on the nominal values.
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46 CFR 190.07-10 - Construction.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Construction. 190.07-10 Section 190.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Structural Fire Protection § 190.07-10 Construction. (a) The hull, superstructure, structural...
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HLA restriction of non-HLA-A, -B, -C and -D cell mediated lympholysis (CML)
International Nuclear Information System (INIS)
Goulmy, E.; Termijtelen, A.; Bradley, B.A.; Rood, J.J. van
1976-01-01
The aim of our study was to define target determinations other than those coded for by the classical HLA-A, -B, -C or -D loci which were responsible for killing in CML. In one of the families studied, strong evidence was found for the existence of a determinant coded for within the HLA region. CML was restricted to targets carrying the classical HLA-Bw35 and Cw4 determinants but the targets were neither HLA-Bw35 nor Cw4 themselves. We therefore concluded that this new HLA determinant was either the product of a new locus closely associated with HLA-B or that it was a product of the classical HLA-B locus which has not been recognized by serology. (author)
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49 CFR 190.209 - Response options.
2010-10-01
... 49 Transportation 3 2010-10-01 2010-10-01 false Response options. 190.209 Section 190.209 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROCEDURES Enforcement § 190.209 Response options. Within 30 days of receipt of a notice of probable...
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46 CFR 190.20-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.20-1 Section 190.20-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Accomodations for Officers, Crew, and Scientific Personnel § 190.20-1 Application. (a) Except as...
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46 CFR 190.20-15 - Construction.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Construction. 190.20-15 Section 190.20-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Accomodations for Officers, Crew, and Scientific Personnel § 190.20-15 Construction. All crew...
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46 CFR 190.01-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.01-1 Section 190.01-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 190.01-1 Application. (a) The provisions of this subpart, with the exception of...
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46 CFR 190.05-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.05-1 Section 190.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT General Fire Protection § 190.05-1 Application. (a) The provisions of this subpart shall apply to...
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46 CFR 190.15-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.15-1 Section 190.15-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Ventilation § 190.15-1 Application. (a) The provisions of this subpart, with the exception of...
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46 CFR 190.07-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.07-1 Section 190.07-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Structural Fire Protection § 190.07-1 Application. (a) The provisions of this subpart, with the...
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Hitachi product data management system toward the 21st century by CALS approach
International Nuclear Information System (INIS)
Yoshinaga, Toshiaki; Kibushi, Haruo; Kitaur, Ayumu
1998-01-01
HIPDM21 (Hitachi Product Data Management System for the 21st century) is a comprehensive computer information management system which has been developed for the purpose of plant life cycle business support in terms of the electronics information exchange and sharing between the disciplines using the product data management technology. The system consists of core systems (Engineering Data Control System, Integrated Commodity Database system, and Document Management System) and business application systems. In the present development phase, the system is being enhanced to support CALS standards including EDT, SGML, and STEP, and to support information exchange and sharing with outside the company including clients, construction companies, and domestic/international vendors. (author)
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46 CFR 190.25-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.25-1 Section 190.25-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Rails and Guards § 190.25-1 Application. (a) The provisions of this subpart with the exception of...
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46 CFR 190.10-1 - Application.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 190.10-1 Section 190.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Means of Escape § 190.10-1 Application. (a) The provisions of this subpart, with the exception of...
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2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Location. 190.10-10 Section 190.10-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Means of Escape § 190.10-10 Location. (a) The two means of escape shall be as remote as...
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21 CFR 137.190 - Cracked wheat.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Cracked wheat. 137.190 Section 137.190 Food and... Related Products § 137.190 Cracked wheat. Cracked wheat is the food prepared by so cracking or cutting into angular fragments cleaned wheat other than durum wheat and red durum wheat that, when tested by...
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Samsung and Volkswagen Crisis Communication in Facebook and Twitter : A Comparative Study
Zhang, Boyang; Veijalainen, Jari; Kotkov, Denis
2017-01-01
Since September 2015 at least two major crises have emerged where major industrial companies producing consumer products have been involved. In September 2015 diesel cars manufactured by Volkswagen turned out to be equipped with cheating software that caused NO2 and other emission values to be reduced to acceptable levels while tested from the real, unacceptable values in normal use. In August 2016 reports began to appear that the battery of a new smart phone produced by Samsung, ...
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Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020
DEFF Research Database (Denmark)
Kildgaard, Sara; de Medeiros, Lívia S; Phillips, Emma
2018-01-01
Cyclopiamines C (1) and D (2) were isolated from the extract of Penicillium sp. CML 3020, a fungus sourced from an Atlantic Forest soil sample. Their structures and relative configuration were determined by 1D and 2D NMR, HRMS, and UV/vis data analysis. Cyclopiamines C and D belong to a small...
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Efficace, Fabio; Baccarani, Michele; Breccia, Massimo; Saussele, Susanne; Abel, Gregory; Caocci, Giovanni; Guilhot, Francois; Cocks, Kim; Naeem, Adel; Sprangers, Mirjam; Oerlemans, Simone; Chie, Weichu; Castagnetti, Fausto; Bombaci, Felice; Sharf, Giora; Cardoni, Annarita; Noens, Lucien; Pallua, Stephan; Salvucci, Marzia; Nicolatou-Galitis, Ourania; Rosti, Gianantonio; Mandelli, Franco
Background Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ
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Efficace, Fabio; Baccarani, Michele; Breccia, Massimo; Saussele, Susanne; Abel, Gregory; Caocci, Giovanni; Guilhot, Francois; Cocks, Kim; Naeem, Adel; Sprangers, Mirjam; Oerlemans, Simone; Chie, Weichu; Castagnetti, Fausto; Bombaci, Felice; Sharf, Giora; Cardoni, Annarita; Noens, Lucien; Pallua, Stephan; Salvucci, Marzia; Nicolatou-Galitis, Ourania; Rosti, Gianantonio; Mandelli, Franco
2014-01-01
Background Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ
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Performance and Safety Tests on Samsung 18650 Li-ion Cells: Two Cell Designs
Deng, Yi; Jeevarajan, Judith; Rehm, Raymond; Bragg, Bobby; Zhang, Wenlin
2002-01-01
In order to meet the applications for space shuttle in future, two types of Samsung cells, with capacity 1800 mAh and 2000 mAh, have been investigated. The studies focused on: (1) Performance tests: completed 250 cycles at various combinations of charge/discharge C rates and discharge capacity measurements at various temperatures; and (2) Safety tests: overcharge and overdischarge, heat abuse, short circuit, internal and external short, and vibration, vacuum, and drop tests
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2010-07-01
... materials from -the cycle. (c) General environment means the total terrestrial, atmospheric and aquatic... of the public means any individual that can receive a radiation dose in the general environment... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Definitions. 190.02 Section 190.02...
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Cheloni, Giulia; Tanturli, Michele
2016-01-01
Chronic myeloid leukemia (CML) is a stem cell-driven disorder caused by the BCR/Abl oncoprotein, a constitutively active tyrosine kinase (TK). Chronic-phase CML patients are treated with impressive efficacy with TK inhibitors (TKi) such as imatinib mesylate (IM). However, rather than definitively curing CML, TKi induces a state of minimal residual disease, due to the persistence of leukemia stem cells (LSC) which are insensitive to this class of drugs. LSC persistence may be due to different reasons, including the suppression of BCR/Abl oncoprotein. It has been shown that this suppression follows incubation in low oxygen under appropriate culture conditions and incubation times.Here we describe the culture repopulation ability (CRA) assay, a non-clonogenic assay capable - together with incubation in low oxygen - to reveal in vitro stem cells endowed with marrow repopulation ability (MRA) in vivo. The CRA assay can be used, before moving to animal tests, as a simple and reliable method for the prescreening of drugs potentially active on CML and other leukemias with respect to their activity on the more immature leukemia cell subsets.
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46 CFR 190.01-15 - Special consideration.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 190.01-15 Section 190.01-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 190.01-15 Special consideration. (a) Special consideration will...
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Astegno, Alessandra; Bonza, Maria Cristina; Vallone, Rosario; La Verde, Valentina; D'Onofrio, Mariapina; Luoni, Laura; Molesini, Barbara; Dominici, Paola
2017-09-08
Calmodulin-like (CML) proteins are major EF-hand-containing, calcium (Ca 2+ )-binding proteins with crucial roles in plant development and in coordinating plant stress tolerance. Given their abundance in plants, the properties of Ca 2+ sensors and identification of novel target proteins of CMLs deserve special attention. To this end, we recombinantly produced and biochemically characterized CML36 from Arabidopsis thaliana We analyzed Ca 2+ and Mg 2+ binding to the individual EF-hands, observed metal-induced conformational changes, and identified a physiologically relevant target. CML36 possesses two high-affinity Ca 2+ /Mg 2+ mixed binding sites and two low-affinity Ca 2+ -specific sites. Binding of Ca 2+ induced an increase in the α-helical content and a conformational change that lead to the exposure of hydrophobic regions responsible for target protein recognition. Cation binding, either Ca 2+ or Mg 2+ , stabilized the secondary and tertiary structures of CML36, guiding a large structural transition from a molten globule apo-state to a compact holoconformation. Importantly, through in vitro binding and activity assays, we showed that CML36 interacts directly with the regulative N terminus of the Arabidopsis plasma membrane Ca 2+ -ATPase isoform 8 (ACA8) and that this interaction stimulates ACA8 activity. Gene expression analysis revealed that CML36 and ACA8 are co-expressed mainly in inflorescences. Collectively, our results support a role for CML36 as a Ca 2+ sensor that binds to and modulates ACA8, uncovering a possible involvement of the CML protein family in the modulation of plant-autoinhibited Ca 2+ pumps. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
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Transition of the Course Programs in the 40 Years History of Hitachi Institute of Technology
Miura, Osamu; Katsura, Koyo; Takahashi, Masahiko
In 2010, the Hitachi Institute of Technology reached the 40th anniversary. In the beginning, the institute stood at the product-out-oriented view point and carried out extensive technical education from basis to advanced technology. After the 1990s, transition of the business environment with the globalization caused that the needs of the engineer education required by the business sections have been transformed. As the result, the changes of needs have been reflected for course program of the institute. Nowadays, in addition to the conventional course programs, the engineer education programs for the business competency and human skill have also been focused.
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Two cases of chronic myelogenous leukemia (CML) treated with Iminitab (Glivec) in different phases
International Nuclear Information System (INIS)
Davoli, R.; Ciarlo, S.; Acosta, I.; Perez, S.; Lagorio, S.; Pratti, A.A.
2003-01-01
Full text: IMINITAB, inhibitor of cytoplasmic transduction signs, and hindering neoplastic cells growth, is a new therapeutic agent for chronic myelogenous leukemia (CML). It is a tyrosine kinase bcrabl inhibitor, inhibiting also the c-kit receptor protein in gastrointestinal neoplasia and small cells lung cancer. The aim of the present work was to evaluate the effect of this agent in CML patients in two different time-periods, namely the chronic phase and the acute one. We hereby present two patients: 1) a 48 years old patient with radioactive contamination history, and 2) a 19 years old patient. In both cases diagnosis was confirmed by BM and BM biopsy, neutrophile alkaline phosphatase, and Ph chromosome t(9;22) (q34;q11). There were non-compatible BM donors available. Both patients were treated with hydroxyurea, hydroxyurea plus interferon, and one of them adding ARAC. Since there was no favorable response an Iminitab course was started. Patient (2) with blastic crisis remitted for 12 month until subsequent relapse and death. Patient (1) treated during chronic phase is still in remission. Neither of them attained negative Ph chromosome. Up to now, current reports show a high percentage of relapse in patients treated during the acute phase, while the chronic ones present a smaller number of relapses. It is to be noted the importance of the follow up during the chronic phase, due to the short time drug utilization in our country (May 2001). Good tolerance and sustained remission in CML patients allows being optimistic regarding this therapeutic agent. (author)
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46 CFR 190.20-35 - Hospital space.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Hospital space. 190.20-35 Section 190.20-35 Shipping... ARRANGEMENT Accomodations for Officers, Crew, and Scientific Personnel § 190.20-35 Hospital space. (a) Except... or more, must be provided with a hospital space. This space must be situated with regard to the...
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46 CFR 190.10-35 - Public spaces.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Public spaces. 190.10-35 Section 190.10-35 Shipping... ARRANGEMENT Means of Escape § 190.10-35 Public spaces. (a) In all cases, public spaces having a deck area of... different corridors, rooms, or spaces to minimize the possibility of one incident blocking both exits. ...
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21 CFR 160.190 - Frozen egg yolks.
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen egg yolks. 160.190 Section 160.190 Food and... CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.190 Frozen egg yolks. (a) Frozen egg yolks, frozen yolks is the food prepared by freezing egg yolks that...
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21 CFR 1.90 - Notice of sampling.
2010-04-01
... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Notice of sampling. 1.90 Section 1.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Imports and Exports § 1.90 Notice of sampling. When a sample of an article offered for import has...
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46 CFR 190.25-10 - Storm rails.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Storm rails. 190.25-10 Section 190.25-10 Shipping COAST... ARRANGEMENT Rails and Guards § 190.25-10 Storm rails. (a) On vessels in ocean and coastwise service, suitable storm rails shall be installed in all passageways and at the deckhouse sides where persons on board...
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3CML: a software application for quality control of multi leaf collimators
International Nuclear Information System (INIS)
Miras, H.; Perez, M. A.; Macias, J.; Moreno, J. C.; Campo, J. L.; Ortiz, M.; Arrans, R.; Ortiz, A.; Terron, J. A.; Fernandez, D.
2011-01-01
The treatments of intensity modulated radiotherapy (IMRT) require a deep knowledge of the accuracy, precision and reproducibility of positioning of the plates that make up the multi leaf collimator (MLC). We have developed a computer application, 3CML, to analyze an image corresponding to a pattern of separate bands irradiation to determine the deviations of the positioning of the blades on the nominal values.
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Directory of Open Access Journals (Sweden)
Masaaki Tsuji
2017-01-01
Full Text Available Myeloid blast crisis of chronic myeloid leukemia (CML-MBC is rarely seen at presentation and has a poor prognosis. There is no standard therapy for CML-MBC. It is often difficult to distinguish CML-MBC from acute myeloid leukemia expressing the Philadelphia chromosome (Ph+ AML. We present a case in which CML-MBC was seen at the initial presentation in a 75-year-old male. He was treated with conventional AML-directed chemotherapy followed by imatinib mesylate monotherapy, which failed to induce response. However, he achieved long-term complete molecular response after combination therapy involving dasatinib, a second-generation tyrosine kinase inhibitor, and conventional chemotherapy.
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GE Hitachi's parts asset management solutions (PAMS)
International Nuclear Information System (INIS)
Varno, M.; Lancaster, K.; Detamore, B.; Dinh, H.; Danielsson, J.; Vitaback, F.
2014-01-01
To ensure operational excellence and improve plant reliability, GE Hitachi Nuclear Energy (GEH) has partnered with its customers to develop PARTS Asset Management Solutions (PAMS). PAMS is a comprehensive set of services that enable plants to proactively manage inventory, obtain after-market replacement parts quickly, and resolve obsolescence issues, ensuring operation of equipment is maintained. PAMS includes: - Electronics Exchange Service Program (EESP) - On-demand exchange service program for GE electronics parts that guarantees rapid shipment of parts, results in cost savings and eliminates all obsolescence risk. - Engineering Services (ES) - Service that finds replacement electronics parts for customers encountering obsolescence. - System Assessment Report (SAR) - Comprehensive, customised report for customer systems that provides all information needed to minimise part availability risk. - Inventory Management (IM) - Visual application based on OEM drawings and decades of industry operational experience that enables customers to proactively identify obsolescence and inventory management issues. - Material Solutions (MS) - Fixed price and lead time model that allows the customer to set-up blanket contracts or purchase orders for obtaining needed parts with a focus on reduced overall cycle time. This paper will provide an overview of PAMS and showcase a case study of the PAMS Digitized deployment for an existing GEH customer. (authors)
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49 CFR 190.323 - Consideration of comments received.
2010-10-01
... 49 Transportation 3 2010-10-01 2010-10-01 false Consideration of comments received. 190.323 Section 190.323 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... SAFETY PROGRAMS AND RULEMAKING PROCEDURES Procedures for Adoption of Rules § 190.323 Consideration of...
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HLA-DRB1*16-restricted recognition of myeloid cells, including CD34+ CML progenitor cells
Ebeling, Saskia B.; Ivanov, Roman; Hol, Samantha; Aarts, Tineke I.; Hagenbeek, Anton; Verdonck, Leo F.; Petersen, Eefke J.
2003-01-01
The therapeutic effect of a human leucocyte antigen (HLA)-identical allogeneic stem cell transplantation (allo-SCT) for the treatment of haematological malignancies is mediated partly by the allogeneic T cells that are administered together with the stem cell graft. Chronic myeloid leukaemia (CML)
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Woessner, David W; Lim, Carol S
2013-01-07
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell. Therapeutic management of CML uses tyrosine kinase inhibitors (TKIs), which block ABL-signaling and effectively kill peripheral cells with BCR-ABL. However, TKIs are not curative, and chronic use is required in order to treat CML. The primary failure for TKIs is through the development of a resistant population due to mutations in the TKI binding regions. This led us to develop the mutant coiled-coil, CC(mut2), an alternative method for BCR-ABL signaling inhibition by targeting the N-terminal oligomerization domain of BCR, necessary for ABL activation. In this article, we explore additional pathways that are important for leukemic stem cell survival in K562 cells. Using a candidate-based approach, we test the combination of CC(mut2) and inhibitors of unique secondary pathways in leukemic cells. Transformative potential was reduced following silencing of the leukemic stem cell factor Alox5 by RNA interference. Furthermore, blockade of the oncogenic protein MUC-1 by the novel peptide GO-201 yielded reductions in proliferation and increased cell death. Finally, we found that inhibiting macroautophagy using chloroquine in addition to blocking BCR-ABL signaling with the CC(mut2) was most effective in limiting cell survival and proliferation. This study has elucidated possible combination therapies for CML using novel blockade of BCR-ABL and secondary leukemia-specific pathways.
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Hehlmann, R; Lauseker, M; Saußele, S; Pfirrmann, M; Krause, S; Kolb, H J; Neubauer, A; Hossfeld, D K; Nerl, C; Gratwohl, A; Baerlocher, G M; Heim, D; Brümmendorf, T H; Fabarius, A; Haferlach, C; Schlegelberger, B; Müller, M C; Jeromin, S; Proetel, U; Kohlbrenner, K; Voskanyan, A; Rinaldetti, S; Seifarth, W; Spieß, B; Balleisen, L; Goebeler, M C; Hänel, M; Ho, A; Dengler, J; Falge, C; Kanz, L; Kremers, S; Burchert, A; Kneba, M; Stegelmann, F; Köhne, C A; Lindemann, H W; Waller, C F; Pfreundschuh, M; Spiekermann, K; Berdel, W E; Müller, L; Edinger, M; Mayer, J; Beelen, D W; Bentz, M; Link, H; Hertenstein, B; Fuchs, R; Wernli, M; Schlegel, F; Schlag, R; de Wit, M; Trümper, L; Hebart, H; Hahn, M; Thomalla, J; Scheid, C; Schafhausen, P; Verbeek, W; Eckart, M J; Gassmann, W; Pezzutto, A; Schenk, M; Brossart, P; Geer, T; Bildat, S; Schäfer, E; Hochhaus, A; Hasford, J
2017-11-01
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytarabine (n=158) or using IM after IFN-failure (n=128). From July 2002 to March 2012, 1551 newly diagnosed patients in chronic phase were randomized into a 5-arm study. The study was powered to detect a survival difference of 5% at 5 years. After a median observation time of 9.5 years, 10-year overall survival was 82%, 10-year progression-free survival was 80% and 10-year relative survival was 92%. Survival between IM400 mg and any experimental arm was not different. In a multivariate analysis, risk group, major-route chromosomal aberrations, comorbidities, smoking and treatment center (academic vs other) influenced survival significantly, but not any form of treatment optimization. Patients reaching the molecular response milestones at 3, 6 and 12 months had a significant survival advantage. For responders, monotherapy with IM400 mg provides a close to normal life expectancy independent of the time to response. Survival is more determined by patients' and disease factors than by initial treatment selection. Although improvements are also needed for refractory disease, more life-time can currently be gained by carefully addressing non-CML determinants of survival.
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Altunkan, Sekip; Ilman, Nevzat; Altunkan, Erkan
2007-04-01
A variety of automatic blood measurement devices with diverse features have been introduced to the medical markets recently. Among these devices, models that measure at the wrist have become increasingly popular in self measurements. The objective of this study was to evaluate the accuracy of the Samsung SBM-100A and Microlife BP 3BU1-5 wrist blood pressure devices against the mercury sphygmomanometer in adults according to the International Protocol criteria. Fifty-four patients over 30 years of age were studied and classified based on the International Protocol range. Blood pressure measurements at the wrist with the Samsung SBM-100A and Microlife BP 3BU1-5 were compared with the results obtained by two trained observers using a mercury sphygmomanometer. Nine sequential blood pressure measurements were taken. A total of 33 participants with randomly distributed arm circumferences were selected for both of the validation studies. During each validation study, 99 measurements were obtained for comparison from 33 participants. The first phase was performed on 15 participants and if the device passed this phase, 18 more participants were selected. Mean discrepancies and standard deviations of the device-sphygmomanometer were 0.9+/-9.2 and -2.7+/-9.3 mmHg for systolic blood pressure and -1.4+/-8.0 mmHg and 1.4+/-5.7 for diastolic blood pressure in the Samsung and Microlife study groups, respectively. The Samsung SBM-100A passed Phase 1 in 15 participants. Despite the fact that Microlife BP 3BU1-5 passed Phase 1 for diastolic pressure, it failed according to the systolic pressure criteria. Eighteen patients were added and Phase 2 was continued, in which Samsung SBM-100A failed to meet the criteria of Phases 2.1 and 2.2 for adults in systolic and diastolic blood pressure. It was found that the Microlife BP 3BU1-5 does not meet the criteria of either of Phases 2.1 and 2.2 for systolic blood pressure and Phase 2.2 for diastolic blood pressure. In this study, Samsung SBM
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Inadvertently programmed bits in Samsung 128 Mbit flash devices: a flaky investigation
Swift, G.
2002-01-01
JPL's X2000 avionics design pioneers new territory by specifying a non-volatile memory (NVM) board based on flash memories. The Samsung 128Mb device chosen was found to demonstrate bit errors (mostly program disturbs) and block-erase failures that increase with cycling. Low temperature, certain pseudo- random patterns, and, probably, higher bias increase the observable bit errors. An experiment was conducted to determine the wearout dependence of the bit errors to 100k cycles at cold temperature using flight-lot devices (some pre-irradiated). The results show an exponential growth rate, a wide part-to-part variation, and some annealing behavior.
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23 CFR 190.3 - Agreement to control advertising.
2010-04-01
... 23 Highways 1 2010-04-01 2010-04-01 false Agreement to control advertising. 190.3 Section 190.3... FOR CONTROLLING OUTDOOR ADVERTISING ON THE INTERSTATE SYSTEM § 190.3 Agreement to control advertising... control outdoor advertising. It must fulfill, and must continue to fulfill its obligations under such...
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38 CFR 52.190 - Infection control.
2010-07-01
... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Infection control. 52.190... FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.190 Infection control. The program management must establish and maintain an infection control program designed to prevent the development and...
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38 CFR 51.190 - Infection control.
2010-07-01
... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Infection control. 51.190... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.190 Infection control. The facility management must establish and maintain an infection control program designed to provide a safe, sanitary, and...
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46 CFR 190.20-50 - Heating and cooling.
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Heating and cooling. 190.20-50 Section 190.20-50... CONSTRUCTION AND ARRANGEMENT Accomodations for Officers, Crew, and Scientific Personnel § 190.20-50 Heating and... the space. (b) Radiators and other heating apparatus must be so placed and shielded, where necessary...
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21 CFR 145.190 - Canned prunes.
2010-04-01
... of a mixture of brown sugar and honey, an appropriate statement would be “___ sirup of brown sugar... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned prunes. 145.190 Section 145.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...
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Wang, Wen-Jun; Zheng, Chao-Feng; Liu, Zhuang; Tan, Yan-Hong; Chen, Xiu-Hua; Zhao, Bin-Liang; Li, Guo-Xia; Xu, Zhi-Fang; Ren, Fang-Gang; Zhang, Yao-Fang; Chang, Jian-Mei; Wang, Hong-Wei
2018-04-25
The present study intended to establish a droplet digital PCR (dd-PCR) for monitoring minimal residual disease (MRD) in patients with BCR/ABL (P210)-positive CML, thereby achieving deep-level monitoring of tumor load and determining the efficacy for guided clinically individualized treatment. Using dd-PCR and RT-qPCR, two cell suspensions were obtained from K562 cells and normal peripheral blood mononuclear cells by gradient dilution and were measured at the cellular level. At peripheral blood(PB) level, 61 cases with CML-chronic phase (CML-CP) were obtained after tyrosine kinase inhibitors (TKIs) treatment and regular follow-ups. By RT-qPCR, BCR/ABL (P210) fusion gene was undetectable in PB after three successive analyses, which were performed once every three months. At the same time, dd-PCR was performed simultaneously with the last equal amount of cDNA. Ten CML patients with MR4.5 were followed up by the two methods. At the cellular level, consistency of results of dd-PCR and RT-qPCR reached R 2 ≥0.99, with conversion equation of Y=33.148X 1.222 (Y: dd-PCR results; X: RT-qPCR results). In the dd-PCR test, 11 of the 61 CML patients (18.03%) tested positive and showed statistically significant difference (PPCR 3 months earlier than by RT-qPCR. In contrast with RT-qPCR, dd-PCR is more sensitive, thus enabling accurate conversion of dd-PCR results into internationally standard RT-qPCR results by conversion equation, to achieve a deeper molecular biology-based stratification of BCR/ABL(P210) MRD. It has some reference value to monitor disease progression in clinic. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
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In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides
The sensory, biological, chemical, and immunological characteristics of foods can be modified non-enzymatically during processing. Notably, these modifications may modulate the allergenic potency of food allergens, such as the Ara h 1 peanut allergen. Carboxymethyl-lysine (CML) modification is a p...
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Use of COTS microelectronics in radiation environments
International Nuclear Information System (INIS)
Winokur, P.S.; Lum, G.K.; Shaneyfelt, M.R.; Sexton, F.W.; Hash, G.L.; Scott, L.
1999-01-01
This paper addresses key issues for the cost-effective use of COTS (Commercially available Off The Shelf) microelectronics in radiation environments that enable circuit or system designers to manage risks and ensure mission success. They review several factors and tradeoffs affecting the successful application of COTS parts including (1) hardness assurance and qualification issues, (2) system hardening techniques, and (3) life-cycle costs. The paper also describes several experimental studies that address trends in total-dose, transient, and single-event radiation hardness as COTS technology scales to smaller feature sizes. As an example, the level at which dose-rate upset occurs in Samsung SRAMs increases from 1.4 x 10 8 rad(Si)/s for a 256K SRAM to 7.7 x 10 9 rad(Si)/s for a 4M SRAM, indicating unintentional hardening improvements in the design of process of a commercial technology. Additional experiments were performed to quantify variations in radiation hardness for COTS parts. In one study, only small (10--15%) variations were found in the dose-rate upset and latchup thresholds for Samsung 4M SRAMs from three different date codes. In another study, irradiations of 4M SRAMs from Samsung, Hitachi, and Toshiba indicate large differences in total-dose radiation hardness. The paper attempts to carefully define terms and clear up misunderstandings about the definitions of COTS and radiation-hardened (RH) technology
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Yani, Ahmad; Farida, Naili
2017-01-01
This research based on the high growth of smartphone business development, this phenomenon is characterized with increasing number of smartphone brand that released by smartphone vendor that offer a lot of new features of its products. Samsung smartphone nowadays being a market leader in Indonesia and in the world, however in 2012-2015 samsung's market share always decreased throughout the year while at the same time market share's rival competitor such as Xiaomi, Oppo, Asus and etc always in...
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Brand Image and Perceived Quality on Consumer Buying Decision of Samsung Mobile Phone in Manado
Tumewu, Ferdinand; Lapian, Joyce; Maindoka, Raiza
2014-01-01
Buying decision is the stage in which consumers make the decision or take an action whether to purchase a certain product or not. The purpose of this research is to analyze the simultaneous effect of brand images and perceived quality of consumer buying decision. This research, the population refers to people in the city of Manado which used mobile phone brand Samsung with sample size as many as 100 respondents. This research used quantitative analyze by using questionnaires and used Multiple...
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Holmgren, Rune
2015-01-01
This thesis explore the energy efficiency of task based programming with OpenMP SuperScalar (OmpSs) on the heterogeneous Samsung Exynos 5422 system on a chip. The system features small energy efficient cores, large high performance cores and a GPGPU, and OmpSs tasks were run on all three different processors. Experiments running a genetic algorithm and a Cholesky decomposition were used to gather results. The option of running applications on the energy efficient cores, on the high perfo...
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International Nuclear Information System (INIS)
Mochida, T.; Hamamoto, M.; Nakamitsu, N.
2016-01-01
Full text: Hitachi-GE Nuclear Energy, Ltd. (HGNE) has more than 40 years BWR plants construction experience. The company continues to develop plant engineering system and plant construction systems based on the experience and the lessons learned. Currently, these systems are integrated in a variety of knowledge bases using the latest information technology (IT). Their performance is continuously validated in the recent NPP constructions. Typical examples are shown as case studies for knowledge management. These plant engineering and construction management systems are essential to achieve the on-time and on-budget-goals in NPP construction projects. (author
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Energy Technology Data Exchange (ETDEWEB)
Okanoue, M
1958-03-01
In the summer of 1965, smoke from a smelter at Hitachi caused injury to a national forest approximately one to three km distant. The smelter had been equipped with control devices and no previous injuries had been reported. An investigation of meteorological conditions at the time of the emission revealed the presence of a temperature inversion between Mt. Kamimine (594 m) and Sukegawa (52 m). However, these inversions are not uncommon in the area. Presumably, poisonous gas was emitted from the smelter chimney as a result of equipment malfunction just at the time of unfavorable meteorological conditions.
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Final report for the 190-D complex decontamination and decommissioning
International Nuclear Information System (INIS)
Thoren, S.D.
1996-09-01
This report documents the decontamination and decommissioning (D ampersand D) of the 190-D complex. (located on the Hanford Site in Richland, Washington). D ampersand D of the 190-D complex included decontaminating and removing hazardous and radiologically contaminated materials; dismantling equipment piping and utility infrastructure; demolishing the structure; and restoring the site. The 100-D Area contains two of the nine inactive plutonium production reactors. The reactor sites are located along the south shore of the Columbia River where the sites cover the northern part of the Hanford Site. The 190-D complex is located in the 100-D Area and is composed of the following seven buildings: 185-D De-aeration Building, 189-D Refrigeration Building, 190-D Tank Room Highbay, 190-D Process Pump Room, 190-DA Process Pump Room Annex, 195-D Vertical Safety Rod Test Tower, 1724-D Underwater Test Facility
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Andu, Risca A.
2013-01-01
Brand personality is a potential marketing strategy to increase the customer loyalty towards the particular brand. Many customers will choose products with a brand that suitable with their personality. It also applies to tablet computer customers. The objectives of this research are to describe the effect of brand personality on customer loyalty in purchasing Apple Ipad and Samsung Galaxy Tab. This research also will analyze the difference in customer loyalty based on brand personality betwee...
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Rumokoy, Farlane; Pangemanan, Sifrid S.; Manorek, Sutria Langling
2015-01-01
Smartphone has been quite a phenomenon especially in Manado city when finding people own more than one is easy. There are so many company involves in Smartphone market one of them is Samsung a Korean company who has been selling many Smartphone despite of a raging battle of competitions, this has become a questions for many people. Marketing is needed for the process of buying and selling a product or service , marketing as a liaison to the process or it can be regarded as a market that meet ...
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International Nuclear Information System (INIS)
Ujita, H.; Futami, T.; Saito, M.; Murata, F.; Shimizu, M.
2012-01-01
Many Asian countries are willing to learn Japanese nuclear power plants experiences, and are interested in introducing nuclear power generation to meet their future energy demand. Special course for Global Nuclear Human Resource Development was established in April, 2011 in the Department of Nuclear Engineering at Graduate School of Tokyo Institute of Technology in cooperation with Hitachi-GE Nuclear Energy. Purpose of the special course is to develop global nuclear engineers and researchers not only in the Tokyo Institute of Technology but also in the educational institutes of Southeast Asian countries
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P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells
International Nuclear Information System (INIS)
Hwang, Melissa; Peddibhotla, Sirisha; McHenry, Peter; Chang, Peggy; Yochum, Zachary; Park, Ko Un; Sears, James Cooper; Vargo-Gogola, Tracy
2012-01-01
Rho GTPases are overexpressed and hyperactivated in many cancers, including breast cancer. Rho proteins, as well as their regulators and effectors, have been implicated in mitosis, and their altered expression promotes mitotic defects and aneuploidy. Previously, we demonstrated that p190B Rho GTPase activating protein (RhoGAP) deficiency inhibits ErbB2-induced mammary tumor formation in mice. Here we describe a novel role for p190B as a regulator of mitosis. We found that p190B localized to centrosomes during interphase and mitosis, and that it is differentially phosphorylated during mitosis. Knockdown of p190B expression in MCF-7 and Hela cells increased the incidence of aberrant microtubule-kinetochore attachments at metaphase, lagging chromosomes at anaphase, and micronucleation, all of which are indicative of aneuploidy. Cell cycle analysis of p190B deficient MCF-7 cells revealed a significant increase in apoptotic cells with a concomitant decrease in cells in G1 and S phase, suggesting that p190B deficient cells die at the G1 to S transition. Chemical inhibition of the Rac GTPase during mitosis reduced the incidence of lagging chromosomes in p190B knockdown cells to levels detected in control cells, suggesting that aberrant Rac activity in the absence of p190B promotes chromosome segregation defects. Taken together, these data suggest that p190B regulates chromosome segregation and apoptosis in cancer cells. We propose that disruption of mitosis may be one mechanism by which p190B deficiency inhibits tumorigenesis
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P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells
Energy Technology Data Exchange (ETDEWEB)
Hwang, Melissa [Department of Biochemistry and Molecular Biology and the Indiana University Simon Cancer Center, Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617 (United States); Peddibhotla, Sirisha [Department of Molecular and Human Genetics, Baylor College of Medicine, John P. McGovern Campus, NABS-0250, Houston, TX 77030 (United States); McHenry, Peter [Department of Biology, Southwestern Adventist University, 100 W. Hillcrest, Keene, TX 76059 (United States); Chang, Peggy; Yochum, Zachary; Park, Ko Un; Sears, James Cooper; Vargo-Gogola, Tracy, E-mail: vargo-gogola.1@nd.edu [Department of Biochemistry and Molecular Biology and the Indiana University Simon Cancer Center, Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617 (United States)
2012-04-25
Rho GTPases are overexpressed and hyperactivated in many cancers, including breast cancer. Rho proteins, as well as their regulators and effectors, have been implicated in mitosis, and their altered expression promotes mitotic defects and aneuploidy. Previously, we demonstrated that p190B Rho GTPase activating protein (RhoGAP) deficiency inhibits ErbB2-induced mammary tumor formation in mice. Here we describe a novel role for p190B as a regulator of mitosis. We found that p190B localized to centrosomes during interphase and mitosis, and that it is differentially phosphorylated during mitosis. Knockdown of p190B expression in MCF-7 and Hela cells increased the incidence of aberrant microtubule-kinetochore attachments at metaphase, lagging chromosomes at anaphase, and micronucleation, all of which are indicative of aneuploidy. Cell cycle analysis of p190B deficient MCF-7 cells revealed a significant increase in apoptotic cells with a concomitant decrease in cells in G1 and S phase, suggesting that p190B deficient cells die at the G1 to S transition. Chemical inhibition of the Rac GTPase during mitosis reduced the incidence of lagging chromosomes in p190B knockdown cells to levels detected in control cells, suggesting that aberrant Rac activity in the absence of p190B promotes chromosome segregation defects. Taken together, these data suggest that p190B regulates chromosome segregation and apoptosis in cancer cells. We propose that disruption of mitosis may be one mechanism by which p190B deficiency inhibits tumorigenesis.
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Use of COTS [commercial-off-the-shelf] Microelectronics in Radiation Environments
International Nuclear Information System (INIS)
Winokur, P.S.; Lum, G.K.; Shaneyfelt, M.R.; Sexton, F.W.; Hash, G.L.; Scott, L.
1999-01-01
This paper addresses key issues for the cost-effective use of COTS microelectronics in radiation environments that enable circuit or system designers to manage risks and ensure mission success. COTS parts with low radiation tolerance should not be used when they degrade mission critical functions or lead to premature system failure. We review several factors and tradeoffs affecting the successful application of COTS parts including (1) hardness assurance and qualification issues, (2) system hardening techniques, and (3) life-cycle costs. The paper also describes several experimental studies that address trends in total-dose, transient, and single-event radiation hardness as COTS technology scales to smaller feature sizes. As an example, the level at which dose-rate upset occurs in Samsung SRAMS increases from 1.4x10 8 rads(Si)/s for a 256K SRAM to 7.7x10 9 rads(Si)/s for a 4M SRAM, indicating unintentional hardening improvements in the design or process of a commercial technology. Additional experiments were performed to quantify variations in radiation hardness for COTS parts. In one study, only small (10-15%) variations were found in the dose-rate upset and latchup thresholds for Samsung 4M SRAMS from three different date codes. In another study, irradiations of 4M SRAMS from Samsung, Hitachi, and Toshiba indicate large differences in total-dose radiation hardness. The paper attempts to carefully define terms and clear up misunderstandings about the definitions of ''COTS'' and ''radiation-hardened'' technology
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Role of STAT3 in Transformation and Drug Resistance in CML
International Nuclear Information System (INIS)
Nair, Rajesh R.; Tolentino, Joel H.; Hazlehurst, Lori A.
2012-01-01
Chronic myeloid leukemia (CML) is initially driven by the bcr–abl fusion oncoprotein. The identification of bcr–abl led to the discovery and rapid translation into the clinic of bcr–abl kinase inhibitors. Although, bcr–abl inhibitors are efficacious, experimental evidence indicates that targeting bcr–abl is not sufficient for elimination of minimal residual disease found within the bone marrow (BM). Experimental evidence indicates that the failure to eliminate the leukemic stem cell contributes to persistent minimal residual disease. Thus curative strategies will likely need to focus on strategies where bcr–abl inhibitors are given in combination with agents that specifically target the leukemic stem cell or the leukemic stem cell niche. One potential target to be exploited is the Janus kinase (JAK)/signal transducers and activators of transcription 3 (STAT3) pathway. Recently using STAT3 conditional knock-out mice it was shown that STAT3 is critical for initiating the disease. Interestingly, in the absence of treatment, STAT3 was not shown to be required for maintenance of the disease, suggesting that STAT3 is required only in the tumor initiating stem cell population (Hoelbl et al., 2010). In the context of the BM microenvironment, STAT3 is activated in a bcr–abl independent manner by the cytokine milieu. Activation of JAK/STAT3 was shown to contribute to cell survival even in the event of complete inhibition of bcr–abl activity within the BM compartment. Taken together, these studies suggest that JAK/STAT3 is an attractive therapeutic target for developing strategies for targeting the JAK–STAT3 pathway in combination with bcr–abl kinase inhibitors and may represent a viable strategy for eliminating or reducing minimal residual disease located in the BM in CML.
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Role of STAT3 in Transformation and Drug Resistance in CML
Energy Technology Data Exchange (ETDEWEB)
Nair, Rajesh R.; Tolentino, Joel H.; Hazlehurst, Lori A., E-mail: lori.hazlehurst@moffitt.org [Molecular Oncology Program, H. Lee Moffitt Cancer Center, Tampa, FL (United States)
2012-04-10
Chronic myeloid leukemia (CML) is initially driven by the bcr–abl fusion oncoprotein. The identification of bcr–abl led to the discovery and rapid translation into the clinic of bcr–abl kinase inhibitors. Although, bcr–abl inhibitors are efficacious, experimental evidence indicates that targeting bcr–abl is not sufficient for elimination of minimal residual disease found within the bone marrow (BM). Experimental evidence indicates that the failure to eliminate the leukemic stem cell contributes to persistent minimal residual disease. Thus curative strategies will likely need to focus on strategies where bcr–abl inhibitors are given in combination with agents that specifically target the leukemic stem cell or the leukemic stem cell niche. One potential target to be exploited is the Janus kinase (JAK)/signal transducers and activators of transcription 3 (STAT3) pathway. Recently using STAT3 conditional knock-out mice it was shown that STAT3 is critical for initiating the disease. Interestingly, in the absence of treatment, STAT3 was not shown to be required for maintenance of the disease, suggesting that STAT3 is required only in the tumor initiating stem cell population (Hoelbl et al., 2010). In the context of the BM microenvironment, STAT3 is activated in a bcr–abl independent manner by the cytokine milieu. Activation of JAK/STAT3 was shown to contribute to cell survival even in the event of complete inhibition of bcr–abl activity within the BM compartment. Taken together, these studies suggest that JAK/STAT3 is an attractive therapeutic target for developing strategies for targeting the JAK–STAT3 pathway in combination with bcr–abl kinase inhibitors and may represent a viable strategy for eliminating or reducing minimal residual disease located in the BM in CML.
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Ru, Yi; Wang, Qinhao; Liu, Xiping; Zhang, Mei; Zhong, Daixing; Ye, Mingxiang; Li, Yuanchun; Han, Hua; Yao, Libo; Li, Xia
2016-06-22
Chronic myeloid leukemia (CML) is characterized by constitutively active fusion protein tyrosine kinase BCR-ABL. Although the tyrosine kinase inhibitor (TKI) against BCR-ABL, imatinib, is the first-line therapy for CML, acquired resistance almost inevitably emerges. The underlying mechanism are point mutations within the BCR-ABL gene, among which T315I is notorious because it resists to almost all currently available inhibitors. Here we took use of a previously generated chimeric ubiquitin ligase, SH2-U-box, in which SH2 from the adaptor protein Grb2 acts as a binding domain for activated BCR-ABL, while U-box from CHIP functions as an E3 ubiquitin ligase domain, so as to target the ubiquitination and degradation of both native and T315I-mutant BCR-ABL. As such, SH2-U-box significantly inhibited proliferation and induced apoptosis in CML cells harboring either the wild-type or T315I-mutant BCR-ABL (K562 or K562R), with BCR-ABL-dependent signaling pathways being repressed. Moreover, SH2-U-box worked in concert with imatinib in K562 cells. Importantly, SH2-U-box-carrying lentivirus could markedly suppress the growth of K562-xenografts in nude mice or K562R-xenografts in SCID mice, as well as that of primary CML cells. Collectively, by degrading the native and T315I-mutant BCR-ABL, the chimeric ubiquitin ligase SH2-U-box may serve as a potential therapy for both imatinib-sensitive and resistant CML.
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Directory of Open Access Journals (Sweden)
Avik Acharya Chowdhury
Full Text Available BACKGROUND: Hydroxychavicol (HCH, a constituent of Piper betle leaf has been reported to exert anti-leukemic activity through induction of reactive oxygen species (ROS. The aim of the study is to optimize the oxidative stress -induced chronic myeloid leukemic (CML cell death by combining glutathione synthesis inhibitor, buthionine sulfoximine (BSO with HCH and studying the underlying mechanism. MATERIALS AND METHODS: Anti-proliferative activity of BSO and HCH alone or in combination against a number of leukemic (K562, KCL22, KU812, U937, Molt4, non-leukemic (A549, MIA-PaCa2, PC-3, HepG2 cancer cell lines and normal cell lines (NIH3T3, Vero was measured by MTT assay. Apoptotic activity in CML cell line K562 was detected by flow cytometry (FCM after staining with annexin V-FITC/propidium iodide (PI, detection of reduced mitochondrial membrane potential after staining with JC-1, cleavage of caspase- 3 and poly (ADP-ribose polymerase proteins by western blot analysis and translocation of apoptosis inducing factor (AIF by confocal microscopy. Intracellular reduced glutathione (GSH was measured by colorimetric assay using GSH assay kit. 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA and 4-amino-5-methylamino-2',7'-difluorofluorescein (DAF-FM were used as probes to measure intracellular increase in ROS and nitric oxide (NO levels respectively. Multiple techniques like siRNA transfection and pharmacological inhibition were used to understand the mechanisms of action. RESULTS: Non-apoptotic concentrations of BSO significantly potentiated HCH-induced apoptosis in K562 cells. BSO potentiated apoptosis-inducing activity of HCH in CML cells by caspase-dependent as well as caspase-independent but apoptosis inducing factor (AIF-dependent manner. Enhanced depletion of intracellular GSH induced by combined treatment correlated with induction of ROS. Activation of ROS- dependent JNK played a crucial role in ERK1/2 activation which subsequently induced the
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Edmonds, Larry D.; Irom, Farokh; Allen, Gregory R.
2017-08-01
A recent model provides risk estimates for the deprogramming of initially programmed floating gates via prompt charge loss produced by an ionizing radiation environment. The environment can be a mixture of electrons, protons, and heavy ions. The model requires several input parameters. This paper extends the model to include TID effects in the control circuitry by including one additional parameter. Parameters intended to produce conservative risk estimates for the Samsung 8 Gb SLC NAND flash memory are given, subject to some qualifications.
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An InGaAs/InP 40 GHz CML static frequency divider
International Nuclear Information System (INIS)
Su Yongbo; Jin Zhi; Cheng Wei; Ge Ji; Wang Xiantai; Chen Gaopeng; Liu Xinyu; Xu Anhuai; Qi Ming
2011-01-01
Static frequency dividers are widely used as a circuit performance benchmark or figure-of-merit indicator to gauge a particular device technology's ability to implement high speed digital and integrated high performance mixed-signal circuits. We report a 2 : 1 static frequency divider in InGaAs/InP heterojunction bipolar transistor technology. This is the first InP based digital integrated circuit ever reported on the mainland of China. The divider is implemented in differential current mode logic (CML) with 30 transistors. The circuit operated at a peak clock frequency of 40 GHz and dissipated 650 mW from a single -5 V supply. (semiconductor integrated circuits)
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Performance evaluation of Samsung LABGEO(HC10) Hematology Analyzer.
Park, Il Joong; Ahn, Sunhyun; Kim, Young In; Kang, Seon Joo; Cho, Sung Ran
2014-08-01
The Samsung LABGEO(HC10) Hematology Analyzer (LABGEO(HC10)) is a recently developed automated hematology analyzer that uses impedance technologies. The analyzer provides 18 parameters including 3-part differential at a maximum rate of 80 samples per hour. To evaluate the performance of the LABGEO(HC10). We evaluated precision, linearity, carryover, and relationship for complete blood cell count parameters between the LABGEO(HC10) and the LH780 (Beckman Coulter Inc) in a university hospital in Korea according to the Clinical and Laboratory Standards Institute guidelines. Sample stability and differences due to the anticoagulant used (K₂EDTA versus K₃EDTA) were also evaluated. The LABGEO(HC10) showed linearity over a wide range and minimal carryover ( 0.92) except for mean corpuscular hemoglobin concentration. The bias estimated was acceptable for all parameters investigated except for monocyte count. Most parameters were stable until 24 hours both at room temperature and at 4°C. The difference by anticoagulant type was statistically insignificant for all parameters except for a few red cell parameters. The accurate results achievable and simplicity of operation make the unit recommendable for small to medium-sized laboratories.
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The Concept of the Luxury Branding in Samsung Galaxy S6 Edge Series Through Triadic Modes of Sign
Paksi, Tiyo; Gunawan, Samuel
2017-01-01
This thesis mainly deals with the iconisation of signs and naturalisation process in order to reveal the way Samsung Galaxy S6 Edge is naturalised as a luxury product. This thesis also involves analysis of the luxury branding concept through the analysis of a product which conceptualises its advertisement using the concept of luxury identifiers. The focus of the writer's analysis is the advertisements themselves as the writer will use the triadic modes of signs, naturalisation process, and th...
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Research activities of Samsung Heavy Industries in the conservation of the environment
International Nuclear Information System (INIS)
Han, B.; Kim, D.K.; Pikaev, A.K.
1998-01-01
Research activities for accelerator fields at Samsung Heavy Industries could be categorized into the accelerator development and its industrial applications. As the initial step of the efforts, high voltage industrial electron accelerators are developed, and development of synchrotron light source and other accelerators are also investigated. The research activities for the applications of accelerator include wastewater treatment, combustion flue gas purification, semiconductor treatment, and other radio-chemical processing. For wastewater treatment, an electron beam pilot plant for treating 1,000m 3 /day of wastewater from 60,000m 3 /day of total dyeing wastewater is under construction in Taegu Dyeing Industrial Complex. A commercial plant for re-circulation of wastewater from papermill company is also under construction in S-paper Co. in Cheongwon city, and after the successful installation, up to 80% of wastewater could be re-used in paper producing process
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International Nuclear Information System (INIS)
Abe, Mitsushi; Takeuchi, Kazuhiro; Fukumoto, Hideshi; Otsuka, Michio
1989-01-01
A magnetic analysis to determine plasma surface position is applied to the magnetic data of the Hitachi Tokamak (HT-2). The analysis takes account of toroidal eddy currents on the vacuum vessel wall. Magnetic probes in HT-2 are placed on both sides of the wall (plasma side and outside), making it possible to determine magnitudes of eddy currents which flow in the toroidal direction. The magnitudes of the coil currents and eddy currents are determined so as to reproduce the measured magnetic fields, and to reconstruct flux surfaces and plasma surface are reconstructed. Taking into account the eddy currents, the determination errors of the plasma surface position are reduced by up to 1/2.3 during start-up and terminating phases, compared with the case without eddy currents. (author)
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Chakraborty, Jayashree B; Mahato, Sanjit K; Joshi, Kalpana; Shinde, Vaibhav; Rakshit, Srabanti; Biswas, Nabendu; Choudhury Mukherjee, Indrani; Mandal, Labanya; Ganguly, Dipyaman; Chowdhury, Avik A; Chaudhuri, Jaydeep; Paul, Kausik; Pal, Bikas C; Vinayagam, Jayaraman; Pal, Churala; Manna, Anirban; Jaisankar, Parasuraman; Chaudhuri, Utpal; Konar, Aditya; Roy, Siddhartha; Bandyopadhyay, Santu
2012-01-01
Alcoholic extract of Piper betle (Piper betle L.) leaves was recently found to induce apoptosis of CML cells expressing wild type and mutated Bcr-Abl with imatinib resistance phenotype. Hydroxy-chavicol (HCH), a constituent of the alcoholic extract of Piper betle leaves, was evaluated for anti-CML activity. Here, we report that HCH and its analogues induce killing of primary cells in CML patients and leukemic cell lines expressing wild type and mutated Bcr-Abl, including the T315I mutation, with minimal toxicity to normal human peripheral blood mononuclear cells. HCH causes early but transient increase of mitochondria-derived reactive oxygen species. Reactive oxygen species-dependent persistent activation of JNK leads to an increase in endothelial nitric oxide synthase-mediated nitric oxide generation. This causes loss of mitochondrial membrane potential, release of cytochrome c from mitochondria, cleavage of caspase 9, 3 and poly-adenosine diphosphate-ribose polymerase leading to apoptosis. One HCH analogue was also effective in vivo in SCID mice against grafts expressing the T315I mutation, although to a lesser extent than grafts expressing wild type Bcr-Abl, without showing significant bodyweight loss. Our data describe the role of JNK-dependent endothelial nitric oxide synthase-mediated nitric oxide for anti-CML activity of HCH and this molecule merits further testing in pre-clinical and clinical settings. © 2011 Japanese Cancer Association.
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Talati, Chetasi; Padron, Eric
2016-12-01
According to the recently published 2016 World Health Organization (WHO) classification of myeloid malignancies, myelodysplastic/myeloproliferative neoplasms (MDS/MPN) include atypical chronic myeloid leukemia (aCML), MDS/MPN-unclassifiable (MDS/MPN-U), chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and MDS/MPN ring sideroblasts with thrombocytosis (MDS/MPN-RS-T). MDS/MPN-RS-T was previously a provisional category known as refractory anemia with ring sideroblasts with thrombocytosis (RARS-T) which has now attained a distinct designation in the 2016 WHO classification. In this review, we focus on biology and management of aCML, MDS/MPN-U, and MDS/MPN-RS-T. There is considerable overlap between these entities which we attempt to further elucidate in this review. We also discuss recent advances in the field of molecular landscape that further defines and characterizes this heterogeneous group of disorders. The paucity of clinical trials available secondary to unclear pathogenesis and rarity of these diseases makes the management of these entities clinically challenging. This review summarizes some of the current knowledge of the molecular pathogenesis and suggested treatment guidelines based on the available data.
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2010-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.190 Updates. (a) The owner or operator shall... later than the date on which a new regulated substance is first present in an already covered process...
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Directory of Open Access Journals (Sweden)
Eliyahu M. Goldratt
2009-09-01
Full Text Available This article analyzes the methodologies of Henry Ford, Taiichi Ohno, and Eliyahu Goldratt and presents explicitly the four principles of flow management according to these operations management philosophies. The differences among them are related to different instances of the same principles in different environments: Ford in his industry focusing on mass production of few (or one products, Ohno at Toyota with the Toyota production System (TPS, and Goldratt in a wide range of production environments. The concepts are illustrated and tested in a practical case of implementation in the Hitachi Tool Engineering company. Here, we have the classic case of an unlikely successful attempt to implement a methodology (Lean, and how the Theory of Constraints (TOC solved this issue. Finally, the limits for the solution proposed by Goldratt for operations management (DBR are described.Este artigo avalia as metodologias de Henry Ford, Taiichi Ohno e Elyahu Goldratt e apresenta de maneira explícita os quatros princípios de gestão do fluxo que estão por trás destas filosofias de gestão de operações. As diferenças entre estas três são traçadas para diferentes instâncias dos mesmos princípios em ambientes específicos: Ford em sua indústria, com foco na produção em massa de poucos (ou um produtos; Ohno na Toyota, com o Toyota Production System (TPS; e Goldratt, em uma classe ampla de ambientes de produção. Os conceitos são ilustrados e postos à prova no caso prático da Hitachi Tool Engineering. Este é o caso clássico de tentativa de implementação de uma metodologia (Lean que não se aplica e como isto foi resolvido pela Teoria das Restrições (TOC. Finalmente os limites da solução proposta por Goldratt para a gestão de operações (TPC são explicitados.
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Use of COTS [commercial-off-the-shelf] Microelectronics in Radiation Environments
Energy Technology Data Exchange (ETDEWEB)
Winokur, P.S.; Lum, G.K.; Shaneyfelt, M.R.; Sexton, F.W.; Hash, G.L.; Scott, L.
1999-07-07
This paper addresses key issues for the cost-effective use of COTS microelectronics in radiation environments that enable circuit or system designers to manage risks and ensure mission success. COTS parts with low radiation tolerance should not be used when they degrade mission critical functions or lead to premature system failure. We review several factors and tradeoffs affecting the successful application of COTS parts including (1) hardness assurance and qualification issues, (2) system hardening techniques, and (3) life-cycle costs. The paper also describes several experimental studies that address trends in total-dose, transient, and single-event radiation hardness as COTS technology scales to smaller feature sizes. As an example, the level at which dose-rate upset occurs in Samsung SRAMS increases from 1.4x10{sup 8} rads(Si)/s for a 256K SRAM to 7.7x10{sup 9} rads(Si)/s for a 4M SRAM, indicating unintentional hardening improvements in the design or process of a commercial technology. Additional experiments were performed to quantify variations in radiation hardness for COTS parts. In one study, only small (10-15%) variations were found in the dose-rate upset and latchup thresholds for Samsung 4M SRAMS from three different date codes. In another study, irradiations of 4M SRAMS from Samsung, Hitachi, and Toshiba indicate large differences in total-dose radiation hardness. The paper attempts to carefully define terms and clear up misunderstandings about the definitions of ''COTS'' and ''radiation-hardened'' technology.
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Tangkuman, Ridsa Septiyan; Saerang, David P.E
2016-01-01
Information and communication technology has made great strides in recent years which also had an effect on advertising such as product placement and celebrity endorsement. Smartphone is one of products that is often to be found on advertising media. This study aims to analyze the effects of product placement in movies and celebrity on consumer purchase with Samsung smartphone as its case study. This is a causal type of research which uses primary data obtained from questionnaires and uses or...
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Han Nguyen
2014-01-01
The objectives of this study is to investigate the impact of culture on advertising appeals in mobile phone industry via social media channel in UK, Brazil and India. Content analysis on Samsung and Nokia commercials in YouTube is conducted. The result indicates that the advertising appeals are both congruent and incongruent with cultural dimensions in UK, Brazil and India. The result suggests that Hofstede and value paradoxes might be the tools to predict the relationshi...
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International Nuclear Information System (INIS)
Kumagai, N.; Ishida, N.; Ootsuka, M.; Kamoshida, M.; Hiranuma, T.; Doumori, S.; Hoshikawa, T.; Shimizu, M.; Kashiwakura, J.; Hayashi, M.
2004-01-01
Hitachi has been developing dual-purpose metal casks for transport and storage of spent nuclear fuels. The Hitachi cask, HDP69B can store 69 BWR fuel assemblies. The cask features are as follows. 1) The fuel basket is assembled mainly with plates of borated stainless steel. The plates are not welded, but cross-inserted into each other like the dividers in an egg carton. Since the borated stainless steel has relatively low heat conductivity, aluminum alloy plates are inserted along with some stainless steel plates to enhance heat removal ability. 2) Cured resin blocks are fitted into the inner shell of the cask for neutron shielding of the cask body. The resin blocks are surrounded by an aluminum casing which transfers heat of stored fuel from the inner shell to the outer shell of the cask. The block type shield structure eliminates the need for welding the heat transfer fins to the inner and outer shells. The weldless structures of the HDP69B lead to its enhanced manufacturability, but they complicate the heat transfer characteristics because there are gaps between such components as the aluminum casing and inner/outer shells. We carried out full-scale prototyping of the HDP69B and ran a heat transfer test using the prototype. The purposes of the heat transfer test were to check the heat removal ability of the HDP69B and to verify the safety analysis model for heat removal. Results of the heat transfer test and optimized analysis model for heat transfer characteristics of the HDP69B are the focus of this paper. The heat transfer test is summarized as follows. Sixty nine heaters simulating the shape and heat power of spent fuel assemblies were inserted into the fuel basket. After replacing the inner atmosphere with 0.1 MPa of helium, the heat transfer test was started. About 7 days were required to equilibrate the temperature distribution. The temperature at the center of the basket was 194 C. The results confirmed the HDP69B had sufficient heat removal ability. The
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42 CFR 415.190 - Conditions of payment: Assistants at surgery in teaching hospitals.
2010-10-01
... teaching hospitals. 415.190 Section 415.190 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... PROVIDERS, SUPERVISING PHYSICIANS IN TEACHING SETTINGS, AND RESIDENTS IN CERTAIN SETTINGS Physician Services in Teaching Settings § 415.190 Conditions of payment: Assistants at surgery in teaching hospitals. (a...
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Dissanayake, Ravindra; Amarasuriya, Thustan
2015-01-01
This paper has focused on reviewing brand identity as an integral strategic component in developing global brands via figuring out literature sources along with the case practices on apple iPhone and Samsung Smart Phone Brands. Researchers followed an approach as literature review along with case review to connect theory into practice by sourcing the formally published evidences. Paper provides the insights on how empirical findings being shared in literature reviews connecting the concept of...
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Lifescience Database Archive (English)
Full Text Available l*ryi*ylyi*k*ll*kfiq*psc*sik*mlqs*wiy*n ynsnrvflf*cq--- ---lffkmsaks*m*i**prssmlckgsp**mfikmsxcp*m*s*sxw*rml...xqip*ttt trslfikmpxkt*m*i**sw*kmlckdsl**sl*frlw*rf*m*n*t*wfkmlcpfrktt pttt*xm**empxrp*m*s*stwkrmlrccp*tttkmlfkmsx...kt*m*sxplw*rmlc*s spr*mfiemsxrp*m*s*stwkrmlrccp*tttkmxikmsxkt*m*nqslw*rmlc*k
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46 CFR 190.15-15 - Ventilation for living spaces and quarters.
2010-10-01
... mechanical system unless it can be shown that a natural system will provide adequate ventilation. By a... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation for living spaces and quarters. 190.15-15... VESSELS CONSTRUCTION AND ARRANGEMENT Ventilation § 190.15-15 Ventilation for living spaces and quarters...
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21 CFR 58.190 - Storage and retrieval of records and data.
2010-04-01
... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Storage and retrieval of records and data. 58.190 Section 58.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., protocols, specimens, and interim and final reports. Conditions of storage shall minimize deterioration of...
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Balducci, Estelle; Loosveld, Marie; Rahal, Ilhem; Boudjarane, John; Alazard, Emilie; Missirian, Chantal; Lafage-Pochitaloff, Marina; Michel, Gérard; Zattara, Hélène
2018-02-01
Discrimination between lymphoid blast crisis of chronic myeloid leukemia (CML) and de novo BCR-ABL1 positive acute lymphoblastic leukemia (ALL) represents a diagnostic challenge because this distinction has a major incidence on the management of patients. Here, we report an uncommon pediatric case of ALL with cryptic ins(22;9)(q11;q34q34) and p190-type BCR-ABL1 transcript. We performed interphase fluorescence in situ hybridization (FISH) for BCR-ABL1 rearrangement on blood neutrophils, which was positive consistent with the diagnosis of lymphoid blast crisis of CML. This case illustrates the major interest of interphase FISH for BCR-ABL1 rearrangement on blood neutrophils as a decisive method to discriminate a lymphoid blast crisis of CML from a de novo BCR-ABL1 positive ALL. Copyright © 2017 John Wiley & Sons, Ltd.
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Energy Technology Data Exchange (ETDEWEB)
Leitao, Catarine Canellas Gondim
2005-04-15
In this work, trace elements were analyzed in serum of patients with chronic myelogenous leukemia (CML) by Total Reflection X-Ray Fluorescence using synchrotron radiation (SRTXRF). Chronic myelogenous leukemia (CML) affects the myeloid cells in the blood and affects 1 to 2 people per 100,000 and accounts for 7-20% cases of leukemia. Sixty patients with CML and sixty healthy volunteers (control group) were studied. Blood was collected into vacutainers without additives. Directly after collection, each blood sample was centrifuged at 3000 rev/min for 10 min in order to separate blood cells and suspended particles from blood serum. Sera were transferred into polyethylene tubes and stored in a freezer at 253 K. A 500 {sup m}u{sup L} serum quantity was spiked with Ga (50 {sup m}u{sup L} ) as internal standard. 10 {sup m}u{sup L} aliquots were pipetted on Perspex sample carrier. After deposition, the samples were left to dry under an infrared lamp. The measurements were performed at the X-Ray Fluorescence Beamline at Brazilian National Synchrotron Light Laboratory (LNLS), using a polychromatic beam. Standard solutions with gallium as internal standard were prepared for calibration system. It was possible to determine the concentrations of the following elements: P, S, Cl, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Br and Rb. Starting from the ANOVA test was observed that the elements P, S, Ca, Cr, Mn, Fe, Cu and Rb presented real significant differences ({alpha} = 0.05) between groups (healthy subjects and CML patients) and Sex (males and females). (author)
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Social Studies, 2004
2004-01-01
Five key questions form the basis of the new CML MediaLit Kit, an educational framework and curriculum guide developed by the Center for Media Literacy. Adaptable to all grades, the key questions help children and young people evaluate the thousands of media messages that bombard them daily. More than two years in development and available for…
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[MPLW515L point mutation in patients with myeloproliferative disease].
Xia, Jun; Xu, Wei; Zhang, Su-Jiang; Fan, Lei; Qiao, Chun; Li, Jian-Yong
2008-12-01
In order to investigate the frequency of MPLW515L and JAK2V617F point mutations of the patients with myeloproliferative disease (MPD) in Nanjing area, MPLW515L and JAK2V617F point mutations were simultaneously detected by alleles specific polymerase chain reaction (AS-PCR) and sequencing in 190 MPD patients. The results showed that MPLW515L point mutation was detected in 1 out of 102 essential thrombocythemia (ET) patients (1.0%) and was not detected in 32 polycythemia vera (PV) patients, 13 idiopathic myelofibrosis (IMF) patients, 43 chronic myelogenous leukemia (CML) patients. JAK2V617F point mutation was detected in 20 out of 32 PV patients (62.5%), 43 out of 102 ET patients (42.2%), 5 out of 13 IMF patients (38.5%), and was not detected in 43 CML patients. It is concluded that MPLW515L point mutation exists in ET patient, but is not found in PV, IMF and CML. JAK2V617F point mutation exists in PV, ET and IMF, but not in CML.
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Energy Technology Data Exchange (ETDEWEB)
Oshima, N; Saiki, Y; Sunaga, K [Hitachi, Ltd., Tokyo (Japan)
1990-10-01
The medium/small-scale HITACHI M-620, M-630, and M-640 computer systems are outlined. Every system is featured by the configuration usable as a medium or small-scale host computer in offices, the function connectable with large-scale host computers, the performance of 5-50 times those of conventional office computers, easy operation and fast processing. As features of the hardware, the one-board CPU and small integrated cubicle structure containing the CPU board, high-speed large-capacity magnetic disk storage device, various kinds of controllers and others are illustrated. As features of the software, the OS (VOS K) featured by the virtual data space control (VDSA) and relational database (RDB) functions, EAGLE/4GL (effective approach to achieving high level software productivity/4th generation language), STEP (self training environmental support program) and simple end user language ACE3/E2 are outlined. 7 figs.
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17 CFR 256.190 - Accumulated deferred income taxes.
2010-04-01
.... proprietary capital ... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 4. Deferred Debits § 256.190 Accumulated deferred income taxes. (a...
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23 CFR 190.5 - Bonus project claims.
2010-04-01
... which advertising controls are in effect. The eligible system mileage reported in subsequent projects on... CONTROLLING OUTDOOR ADVERTISING ON THE INTERSTATE SYSTEM § 190.5 Bonus project claims. (a) The State may claim payment by submitting a form PR-20 voucher, supported by strip maps which identify advertising control...
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49 CFR 190.233 - Corrective action orders.
2010-10-01
... effective, the Associate Administrator, OPS may request the Attorney General to bring an action for appropriate relief in accordance with § 190.235. (i) Upon petition by the Attorney General, the District... must notify the Associate Administrator, OPS of that election in writing within 10 days of service of...
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Rădulescu, I R; Cândea, D; Halanay, A
2014-12-21
We study a mathematical model describing the dynamics of leukemic and normal cell populations (stem-like and differentiated) in chronic myeloid leukemia (CML). This model is a system of four delay differential equations incorporating three types of cell division. The competition between normal and leukemic stem cell populations for the common microenvironment is taken into consideration. The stability of one steady state is investigated. The results are discussed via their medical interpretation. Copyright © 2014 Elsevier Ltd. All rights reserved.
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190-C Facility <90 Day Storage Pad training plan
International Nuclear Information System (INIS)
Little, N.C.
1996-12-01
This is the Environmental Restoration Contractor (ERC) team training plan for the 190-C Facility <90 Day Storage Pad of Hazardous Waste. It is intended to meet the requirements of Washington Administrative Code (WAC) 173-303-330 and the Hanford Dangerous Waste Permit. Training unrelated to compliance with WAC 173-303-330 is not addressed in this training plan. WAC 173-303-330(1)(d)(ii, v, vi) requires that personnel be familiarized, where applicable, with waste feed cut-off systems, response to ground-water contamination incidents, and shutdown of operations. These are not applicable to 190-C Facility <90 Day Storage Pad, and are therefore not covered in this training plan
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Phenotype-gene: 190 [Arabidopsis Phenome Database[Archive
Lifescience Database Archive (English)
Full Text Available 190 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1188i decreased responsivity under influence...:471-81. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18263776i decreased responsivity under influence
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Intracellular Retention of ABL Kinase Inhibitors Determines Commitment to Apoptosis in CML Cells
Dziadosz, Marek; Schnöder, Tina; Heidel, Florian; Schemionek, Mirle; Melo, Junia V.; Kindler, Thomas; Müller-Tidow, Carsten; Koschmieder, Steffen; Fischer, Thomas
2012-01-01
Clinical development of imatinib in CML established continuous target inhibition as a paradigm for successful tyrosine kinase inhibitor (TKI) therapy. However, recent reports suggested that transient potent target inhibition of BCR-ABL by high-dose TKI (HD-TKI) pulse-exposure is sufficient to irreversibly commit cells to apoptosis. Here, we report a novel mechanism of prolonged intracellular TKI activity upon HD-TKI pulse-exposure (imatinib, dasatinib) in BCR-ABL-positive cells. Comprehensive mechanistic exploration revealed dramatic intracellular accumulation of TKIs which closely correlated with induction of apoptosis. Cells were rescued from apoptosis upon HD-TKI pulse either by repetitive drug wash-out or by overexpression of ABC-family drug transporters. Inhibition of ABCB1 restored sensitivity to HD-TKI pulse-exposure. Thus, our data provide evidence that intracellular drug retention crucially determines biological activity of imatinib and dasatinib. These studies may refine our current thinking on critical requirements of TKI dose and duration of target inhibition for biological activity of TKIs. PMID:22815843
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Cardoso, Eve Alexandra Reyes Pinto
2017-01-01
Esta dissertação irá consistir na análise do êxito da internacionalização das duas grandes empresas na indústria de smartphones: nomeadamente a Apple Inc. E a Samsung Electronics. A importância deste estudo consiste no fato de que estas duas grandes empresas foram construídas em dois países diferentes com estratégias de ação distintas. Ambas as empresas, aplicam diferentes abordagens no seu processo de internacionalização. No entanto, hoje em dia as duas empresas são líderes do mercado. ...
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28 CFR 0.190 - Changes within organizational units.
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Changes within organizational units. 0... JUSTICE Sections and Subunits § 0.190 Changes within organizational units. (a) The head of each Office... termination of major functions within his organizational unit as he may deem necessary or appropriate. In each...
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Spitzer Observations of a 24 μm Shadow: Bok Globule CB 190
Stutz, Amelia M.; Bieging, John H.; Rieke, George H.; Shirley, Yancy L.; Balog, Zoltan; Gordon, Karl D.; Green, Elizabeth M.; Keene, Jocelyn; Kelly, Brandon C.; Rubin, Mark; Werner, Michael W.
2007-08-01
We present Spitzer observations of the dark globule CB 190 (LDN 771). We observe a roughly circular 24 μm shadow with a 70" radius. The extinction profile of this shadow matches the profile derived from 2MASS photometry at the outer edges of the globule and reaches a maximum of ~32 visual magnitudes at the center. The corresponding mass of CB 190 is ~10 Msolar. Our 12CO and 13CO J=2-1 data over a 10'×10' region centered on the shadow show a temperature ~10 K. The thermal continuum indicates a similar temperature for the dust. The molecular data also show evidence of freezeout onto dust grains. We estimate a distance to CB 190 of 400 pc using the spectroscopic parallax of a star associated with the globule. Bonnor-Ebert fits to the density profile, in conjunction with this distance, yield ξmax=7.2, indicating that CB 190 may be unstable. The high temperature (56 K) of the best-fit Bonnor-Ebert model is in contradiction with the CO and thermal continuum data, leading to the conclusion that the thermal pressure is not enough to prevent free-fall collapse. We also find that the turbulence in the cloud is inadequate to support it. However, the cloud may be supported by the magnetic field, if this field is at the average level for dark globules. Since the magnetic field will eventually leak out through ambipolar diffusion, it is likely that CB 190 is collapsing or in a late precollapse stage. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 1407.
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Three-dimensional structure and stoichiometry of Helmintosporium victoriae190S totivirus
International Nuclear Information System (INIS)
Caston, Jose R.; Luque, Daniel; Trus, Benes L.; Rivas, German; Alfonso, Carlos; Gonzalez, Jose M.; Carrascosa, Jose L.; Annamalai, Padmanaban; Ghabrial, Said A.
2006-01-01
Most double-stranded RNA viruses have a characteristic capsid consisting of 60 asymmetric coat protein dimers in a so-called T = 2 organization, a feature probably related to their unique life cycle. These capsids organize the replicative complex(es) that is actively involved in genome transcription and replication. Available structural data indicate that their RNA-dependent RNA polymerase (RDRP) is packaged as an integral capsid component, either as a replicative complex at the pentameric vertex (as in reovirus capsids) or as a fusion protein with the coat protein (as in some totivirus). In contrast with members of the family Reoviridae, there are two well-established capsid arrangements for dsRNA fungal viruses, exemplified by the totiviruses L-A and UmV and the chrysovirus PcV. Whereas L-A and UmV have a canonical T = 2 capsid, the PcV capsid is based on a T = 1 lattice composed of 60 capsid proteins. We used cryo-electron microscopy combined with three-dimensional reconstruction techniques and hydrodynamic analysis to determine the structure at 13.8 A resolution of Helminthosporium victoriae 190S virus (Hv190SV), a totivirus isolated from a filamentous fungus. The Hv190SV capsid has a smooth surface and is based on a T = 2 lattice with 60 equivalent dimers. Unlike the RDRP of some other totiviruses, which are expressed as a capsid protein-RDRP fusion protein, the Hv190SV RDRP is incorporated into the capsid as a separate, nonfused protein, free or non-covalently associated to the capsid interior
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33 CFR 110.190 - Tortugas Harbor, in vicinity of Garden Key, Dry Tortugas, Fla.
2010-07-01
... Garden Key, Dry Tortugas, Fla. 110.190 Section 110.190 Navigation and Navigable Waters COAST GUARD..., in vicinity of Garden Key, Dry Tortugas, Fla. (a) The anchorage grounds. All of Bird Key Harbor, southwest of Garden Key, bounded by the surrounding reefs and shoals and, on the northeast, by a line...
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2010-07-01
..., fans and other such devices allowed in Government-controlled facilities? 102-74.190 Section 102-74.190... § 102-74.190 Are portable heaters, fans and other such devices allowed in Government-controlled facilities? Federal agencies are prohibited from operating portable heaters, fans, and other such devices in...
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Quadrupole moments of the 12+ isomers in 188Hg and 190Hg
International Nuclear Information System (INIS)
Dracoulis, G.D.; Lonnroth, T.; Vajda, S.; Dafni, E.; Schatz, G.
1984-01-01
The electric quadrupole interaction of the 12 + isomers in 188 Hg and 190 Hg has been measured in solid Hg. The quadrupole moments deduced, vertical strokeQ[ 188 Hg(12 + )]vertical stroke = 91(11) e fm 2 and vertical strokeQ[ 190 Hg(12 + )]vertical stroke = 117(14) e fm 2 suggest a possible change in γ-deformation due to the rotation alignment of the isub(13/2) quasi-neutrons. The temperature dependence of the electric field gradient tensor in Hg was also determined. (orig.)
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Alpha activity of 190 Pt isotope measured with CR-39 track detector
International Nuclear Information System (INIS)
Tavares, O.A.P.; Terranova, M.L.
1996-11-01
A new method to measure alpha activity of long-lived radioisotopes is reported. The method consists basically in using CR-39 track detectors in close contact with thick samples of the radioelement to be investigated. Accordingly, a long-term exposure experiment has been performed using metallic sheets of natural platinum to measure alpha activity of platinum 190 isotope. The half-life of platinum 190 has been obtained in good agreement with two recent theoretical half-life predictions. (author). 21 refs., 3 figs., 2 tabs
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2010-01-01
... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Transactions in slaughtered poultry and other poultry products restricted; vehicle sanitation requirements. 381.190 Section 381.190... sanitation requirements. (a) No person shall sell, transport, offer for sale or transportation, or receive...
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41 CFR 102-33.190 - What are the aircraft operations and ownership costs for which we must account?
2010-07-01
... operations and ownership costs for which we must account? 102-33.190 Section 102-33.190 Public Contracts and... Parts Accounting for the Cost of Government Aircraft § 102-33.190 What are the aircraft operations and ownership costs for which we must account? You must account for the operations and ownership costs of your...
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Directory of Open Access Journals (Sweden)
Shantashri Vaidya
Full Text Available BACKGROUND: Mutations in the ABL kinase domain and SH3-SH2 domain of the BCR/ABL gene and amplification of the Philadelphia chromosome are the two important BCR/ABL dependent mechanisms of imatinib resistance. Here, we intended to study the role played by TKI, imatinib, in selection of gene mutations and development of chromosomal abnormalities in Indian CML patients. METHODS: Direct sequencing methodology was employed to detect mutations and conventional cytogenetics was done to identify Philadelphia duplication. RESULTS: Among the different mechanisms of imatinib resistance, kinase domain mutations (39% of the BCR/ABL gene were seen to be more prevalent, followed by mutations in the SH3-SH2 domain (4% and then BCR/ABL amplification with the least frequency (1%. The median duration of occurrence of mutation was significantly shorter for patients with front line imatinib than those pre-treated with hydroxyurea. Patients with high Sokal score (p = 0.003 showed significantly higher incidence of mutations, as compared to patients with low/intermediate score. Impact of mutations on the clinical outcome in AP and BC was observed to be insignificant. Of the 94 imatinib resistant patients, only 1 patient exhibited duplication of Philadelphia chromosome, suggesting a less frequent occurrence of this abnormality in Indian CML patients. CONCLUSION: Close monitoring at regular intervals and proper analysis of the disease resistance would facilitate early detection of resistance and thus aid in the selection of the most appropriate therapy.
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Samsung Electro-Mechanics - электронные компоненты: прорыв на российском рынке
Асташкевич, Павел
2002-01-01
— Марка Samsung хорошо известна в России в основном благодаря бытовой технике этой компании. Нашим читателям было бы интересно больше узнать о Samsung Electro-Mechanics.
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Anggraeni, Melisa R; Connors, Natalie K; Wu, Yang; Chuan, Yap P; Lua, Linda H L; Middelberg, Anton P J
2013-09-13
Biomolecular engineering enables synthesis of improved proteins through synergistic fusion of modules from unrelated biomolecules. Modularization of peptide antigen from an unrelated pathogen for presentation on a modular virus-like particle (VLP) represents a new and promising approach to synthesize safe and efficacious vaccines. Addressing a key knowledge gap in modular VLP engineering, this study investigates the underlying fundamentals affecting the ability of induced antibodies to recognize the native pathogen. Specifically, this quality of immune response is correlated to the peptide antigen module structure. We modularized a helical peptide antigen element, helix 190 (H190) from the influenza hemagglutinin (HA) receptor binding region, for presentation on murine polyomavirus VLP, using two strategies aimed to promote H190 helicity on the VLP. In the first strategy, H190 was flanked by GCN4 structure-promoting elements within the antigen module; in the second, dual H190 copies were arrayed as tandem repeats in the module. Molecular dynamics simulation predicted that tandem repeat arraying would minimize secondary structural deviation of modularized H190 from its native conformation. In vivo testing supported this finding, showing that although both modularization strategies conferred high H190-specific immunogenicity, tandem repeat arraying of H190 led to a strikingly higher immune response quality, as measured by ability to generate antibodies recognizing a recombinant HA domain and split influenza virion. These findings provide new insights into the rational engineering of VLP vaccines, and could ultimately enable safe and efficacious vaccine design as an alternative to conventional approaches necessitating pathogen cultivation. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Evaluation of tumor registry validity in Samsung medical center radiation oncology department
International Nuclear Information System (INIS)
Park, Won; Huh, Seung Jae; Kim, Dae Yong; Shin, Seong Soo; Ahn, Yong Chan; Lim, Do Hoon; Kim, Seon Woo
2004-01-01
A tumor registry system for the patients treated by radiotherapy at Samsung Medical Center since the opening of a hospital at 1994 was employed. In this study, the tumor registry system was introduced and the validity of the tumor registration was analyzed. The tumor registry system was composed of three parts: patient demographic, diagnostic, and treatment information. All data were input in a screen using a mouse only. Among the 10,000 registered cases in the tumor registry system until Aug, 2002, 199 were randomly selected and their registration data were compared with the patients' medical records. Total input errors were detected in 15 cases (7.5%). There were 8 error items in the part relating to diagnostic information: tumor site 3, pathology 2, AJCC staging 2 and performance status 1. In the part relating to treatment information there were 9 mistaken items: combination treatment 4, the date of initial treatment 3 and radiation completeness 2. According to the assignment doctor, the error ratio was consequently variable. The doctors who did no double-checks showed higher errors than those that did (15.6%: 3.7%). Our tumor registry had errors within 2% for each item. Although the overall data quality was high, further improvement might be achieved through promoting sincerity, continuing training periodic validity tests and keeping double-checks. Also, some items associated with the hospital information system will be input automatically in the next step
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17 CFR 190.07 - Calculation of allowed net equity.
2010-04-01
...; and (iii) The current realizable market value, determined as of the close of the market on the last... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Calculation of allowed net... BANKRUPTCY § 190.07 Calculation of allowed net equity. Allowed net equity shall be computed as follows: (a...
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Troise, A.D.; Fiore, A.; Wiltafsky, M.; Fogliano, V.
2015-01-01
The control of Maillard reaction (MR) is a key point to ensure processed foods quality. Due to the presence of a primary amino group on its side chain, lysine is particularly prone to chemical modifications with the formation of Amadori products (AP), Nε-(Carboxymethyl)-L-lysine (CML),
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Troise, Antonio Dario; Fiore, Alberto; Wiltafsky, Markus; Fogliano, Vincenzo
2015-12-01
The control of Maillard reaction (MR) is a key point to ensure processed foods quality. Due to the presence of a primary amino group on its side chain, lysine is particularly prone to chemical modifications with the formation of Amadori products (AP), Nε-(Carboxymethyl)-L-lysine (CML), Nε-(Carboxyethyl)-L-lysine (CEL). A new analytical strategy was proposed which allowed to simultaneously quantify lysine, CML, CEL and the Nε-(2-Furoylmethyl)-L-lysine (furosine), the indirect marker of AP. The procedure is based on stable isotope dilution assay followed by liquid chromatography tandem mass spectrometry. It showed high sensitivity and good reproducibility and repeatability in different foods. The limit of detection and the RSD% were lower than 5 ppb and below 8%, respectively. Results obtained with the new procedure not only improved the knowledge about the reliability of thermal treatment markers, but also defined new insights in the relationship between Maillard reaction products and their precursors. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Diagnostic radiography as a risk factor for chronic myeloid and monocytic leukaemia (CML)
International Nuclear Information System (INIS)
Preston-Martin, S.; Thomas, D.C.; Yu, M.C.; Henderson, B.E.
1989-01-01
The study included 136 Los Angeles County residents aged 20-69 with chronic myeloid and monocytic leukemia CML diagnosed from 1979 to 1985 (cases) and 136 neighbourhood controls. During 3-20 years before diagnosis more cases than controls had radiographic examinations of back, gastrointestinal (GI) tract and kidneys, and cases more often had GI and back radiography on multiple occasions (odds ratio (OR) for back X-rays on five or more occasions = 12.0; P < 0.01). Published estimates were used to assign a minimum dose to active bone marrow for various radiographic procedures. ORs were estimated for cumulative marrow doses for each of four time periods (3-5 years, 6-10 years, 11-20 years and 3-20 years before diagnosis). ORs for exposure to 0.99, 100-999, 1000-1999 and ≥ 2000 mrad in the 3-20 years before diagnosis were 1.0, 1.4, 1.6 and 2.4 (P for highest exposure category and P for trend both < 0.05). The association was strongest for 6-10 years before diagnosis, and effects of radiation exposure during this period remained significant after consideration of other risk factors in a logistic regression analysis. (author)
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P190-B RhoGAP (p190-B, also known as ARHGAP5) has been shown to play an essential role in invasion of the terminal end buds (TEBs) into the surrounding fat pad during mammary gland ductal morphogenesis. Here we report that embryos with a homozygous p190-B gene deletion exhibit major defects in embry...
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A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.
Directory of Open Access Journals (Sweden)
Katherine Stewart
2016-02-01
Full Text Available Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs, including p190A, that promote the intrinsic GTPase activity of Rho proteins. In the current study we have performed a small-scale ENU mutagenesis screen and identified a novel loss of function allele of the p190A gene Arhgap35, which introduces a Leu1396 to Gln substitution in the GAP domain. This results in decreased GAP activity for the prototypical Rho-family members, RhoA and Rac1, likely due to disrupted ordering of the Rho binding surface. Consequently, Arhgap35-deficient animals exhibit hypoplastic and glomerulocystic kidneys. Investigation into the cystic phenotype shows that p190A is required for appropriate primary cilium formation in renal nephrons. P190A specifically localizes to the base of the cilia to permit axoneme elongation, which requires a functional GAP domain. Pharmacological manipulations further reveal that inhibition of either Rho kinase (ROCK or F-actin polymerization is able to rescue the ciliogenesis defects observed upon loss of p190A activity. We propose a model in which p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation. Together, our results establish an unexpected link between Rho GTPase regulation, ciliogenesis and glomerulocystic kidney disease.
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New evaluation of alpha decay half-life of 190Pt isotope for the Pt-Os dating system
International Nuclear Information System (INIS)
Tavares, O.A.P.; Medeiros, E.L.; Terranova, M.L.
2005-08-01
A semiempirical model based on the quantum mechanical tunnelling mechanism of alpha emission from nuclei has been used to evaluate the half-life of the Pt isotopes. For the important naturally occurring 190 Pt isotope, the radiogenic parent in the 190 Pt → 186 Os dating system, the model yielded a half-life value of (3.7± 0.3) versus 10 11 y. This is comparable to (3.2±0.1) versus 10 11 y which was obtained in the last direct counting experiment to measure the alpha activity of 190 Pt (Tavares and Terranova, Rad. Measurem. 27 (1997) 19). A literature survey of available alpha decay half-life values for 190 Pt isotope is also reported. The significant discrepancies found between data obtained by direct counting, indirect geological methods and different calculation models are analysed and discussed. (author)
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27 CFR 9.190 - Red Hill Douglas County, Oregon.
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Red Hill Douglas County... Areas § 9.190 Red Hill Douglas County, Oregon. (a) Name. The name of the viticultural area described in this section is “Red Hill Douglas County, Oregon”. For purposes of part 4 of this chapter, “Red Hill...
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Predicting superdeformed rotational band-head spin in A ∼ 190 ...
Indian Academy of Sciences (India)
PACS No. 21.60.−n. 1. Introduction. Superdeformed (SD) nuclei are one of the most challenging and ... like A ∼ 60, 80, 130, 150 and 190 [2,3]. ..... work and the research is progressing to give systematic features of rotational bands of SD.
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Evidence for octupole vibration in the superdeformed well of {sup 190}Hg from eurogam
Energy Technology Data Exchange (ETDEWEB)
Crowell, B.; Carpenter, M.P.; Janssens, R.V.F. [and others
1995-08-01
Gammasphere experiments in 1993-94 brought to light the existence of an excited superdeformed (SD) band in {sup 190}Hg with the unusual property of decaying entirely to the lowest (yrast) SD band over 3-4 transitions, rather than to the normally deformed states as is usually the case in the A {approximately} 150 and A {approximately} 190 regions of superdeformation. Although M1 transitions between signature-partner SD bands were previously observed in {sup 193}Hg, no such mechanism was available to explain the situation in the even-even nucleus {sup 190}Hg, whose yrast SD band has no signature partner. The best explanation appears to lie in long-standing theoretical predictions that the SD minimum in the potential energy surface would be quite soft with respect to octupole vibrations. This would lead to enhanced E1 transitions connecting the one-phonon and zero-phonon states. The data and this interpretation were published. A shortcoming of the Gammasphere experiments was that they did not allow the definitive measurement of the energies of the gamma-ray transitions connecting the two bands, due to the very weak population of the excited band ({approximately}0.05% of the {sup 190}Hg channel) and also partly, we believed, to the angular distributions of the transitions, which were peaked near 90 degrees, where Gammasphere had few detectors.
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Review of the technical bases of 40 CFR Part 190.
Energy Technology Data Exchange (ETDEWEB)
Kelly, John E.; McMahon, Kevin A.; Siegel, Malcolm Dean; Weiner, Ruth F.; Bixler, Nathan E.; Klein, Keith A. (Longenecker and Associates)
2010-07-01
The dose limits for emissions from the nuclear fuel cycle were established by the Environmental Protection Agency in 40 CFR Part 190 in 1977. These limits were based on assumptions regarding the growth of nuclear power and the technical capabilities of decontamination systems as well as the then-current knowledge of atmospheric dispersion and the biological effects of ionizing radiation. In the more than thirty years since the adoption of the limits, much has changed with respect to the scale of nuclear energy deployment in the United States and the scientific knowledge associated with modeling health effects from radioactivity release. Sandia National Laboratories conducted a study to examine and understand the methodologies and technical bases of 40 CFR 190 and also to determine if the conclusions of the earlier work would be different today given the current projected growth of nuclear power and the advances in scientific understanding. This report documents the results of that work.
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Zhao, J J; Zhang, Y L; Zhang, S J; Zhou, J; Yu, F K; Zu, Y L; Zhao, H F; Li, Z; Song, Y P
2018-03-14
Objective: To investigate the molecular-cytogenetic characterization and impact on tyrosine kinase inhibitors (TKIs) therapy in chronic phase of chronic myeloid leukemia (CML-CP) patients with variant Ph chromosome (vPh). Methods: The clinical data of 32 patients with vPh chromosomes were collected and compared with 703 patients with typical Ph chromosome in newly diagnosed CML-CP who were on first-line imatinib (IM) and with BCR-ABL transcript of P210. Results: There was no significant difference in demographic and hematological characteristics between vPh and classic Ph patients. 3(9.4%) of the 32 vPh cases were simple variant translocations. Among the remaining 29 cases with complex variant translocations, 28 cases (87.5%) involved 3 chromosomes, and only 1 (3.1%) involved 4 chromosomes. Except for 8, 15, 18, X, and Y chromosomes, the other chromosomes were involved. The frequency of chromosome 12q(15.5%) and 1p (12.1%) were higher involved. The most common FISH signal pattern was 2G2R1Y (74.1%), followed by 1G1R2F (14.8%), 2G1R1Y (3.7%), 1G2R1Y (3.7%), 1G1R1Y (3.7%). The comparison of complete cytogenetic response (CCyR) ( P =0.269), major molecular response (MMR) ( P =0.391) were carried out between simple and complex mechanisms, without difference. Compared with the classic Ph, the patients with vPh had higher IM primary resistance rate ( χ 2 =3.978, P =0.046), especially primary hematological resistance ( χ 2 =7.870, P =0.005), but the difference of CCyR ( χ 2 =0.192, P =0.661), MMR ( χ 2 =0.822, P =0.365), EFS ( χ 2 =0.509, P =0.476), OS ( χ 2 =3.485, P =0.062) were not statistically significant, and multivariate analysis showed that the presence of vPh did not affect OS ( RR =0.692, 95% CI 0.393-1.765, P =0.658)、EFS ( RR =0.893, 95% CI 0.347-2.132, P =0.126) and PFS ( RR =1.176, 95% CI 0.643-2.682, P =0.703). Conclusion: CML-CP patients with vPh and classic Ph had similar demographic and hematological characteristics. Except for 22q11, 9q34, the
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Microscopic structure of high-spin vibrational states in superdeformed A=190 nuclei
Energy Technology Data Exchange (ETDEWEB)
Nakatsukasa, Takashi [Chalk River Labs., Ontario (Canada); Matsuyanagi, Kenichi [Kyoto Univ. (Japan); Mizutori, Shoujirou [Oak Ridge National Lab., TN (United States)] [and others
1996-12-31
Microscopic RPA calculations based on the cranked shell model are performed to investigate the quadrupole and octupole correlations for excited superdeformed (SD) bands in even-even A=190 nuclei. The K = 2 octupole vibrations are predicted to be the lowest excitation modes at zero rotational frequency. The Coriolis coupling at finite frequency produces different effects depending on the neutron and proton number of nucleus. The calculations also indicate that some collective excitations may produce moments of inertia almost identical to those of the yrast SD band. An interpretation of the observed excited bands invoking the octupole vibrations is proposed, which suggests those octupole vibrations may be prevalent in even-even SD A=190 nuclei.
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Inter-band coincidences in the superdeformed well of {sup 190}Hg from gammasphere
Energy Technology Data Exchange (ETDEWEB)
Crowell, B.; Carpenter, M.P.; Janssens, R.V.F. [and others
1995-08-01
Very few experimental observables are ordinarily accessible for superdeformed (SD) states in the A {approximately} 150 and A {approximately} 190 regions. The gamma-decay out of the superdeformed bands usually proceeds directly to the normally deformed states, through highly fragmented pathways, making it difficult to determine the spins, parities and excitation energies of the SD states. The in-band E2 transitions are so collective (2 x 10{sup 3} single-particle units in the A {approximately} 190 region) that it is typically impossible to detect any of the competing M1 and E1 transitions between states in the SD well.
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c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells.
Waldron, T; De Dominici, M; Soliera, A R; Audia, A; Iacobucci, I; Lonetti, A; Martinelli, G; Zhang, Y; Martinez, R; Hyslop, T; Bender, T P; Calabretta, B
2012-04-01
Expression of c-Myb is required for normal hematopoiesis and for proliferation of myeloid leukemia blasts and a subset of T-cell leukemia, but its role in B-cell leukemogenesis is unknown. We tested the role of c-Myb in p190(BCR/ABL)-dependent B-cell leukemia in mice transplanted with p190(BCR/ABL)-transduced marrow cells with a c-Myb allele (Myb(f/d)) and in double transgenic p190(BCR/ABL)/Myb(w/d) mice. In both models, loss of a c-Myb allele caused a less aggressive B-cell leukemia. In p190(BCR/ABL)-expressing human B-cell leukemia lines, knockdown of c-Myb expression suppressed proliferation and colony formation. Compared with c-Myb(w/f) cells, expression of Bmi1, a regulator of stem cell proliferation and maintenance, was decreased in pre-B cells from Myb(w/d) p190(BCR/ABL) transgenic mice. Ectopic expression of a mutant c-Myb or Bmi1 enhanced the proliferation and colony formation of Myb(w/d) p190(BCR/ABL) B-cells; by contrast, Bmi1 downregulation inhibited colony formation of p190(BCR/ABL)-expressing murine B cells and human B-cell leukemia lines. Moreover, c-Myb interacted with a segment of the human Bmi1 promoter and enhanced its activity. In blasts from 19 Ph(1) adult acute lymphoblastic leukemia patients, levels of c-Myb and Bmi1 showed a positive correlation. Together, these findings support the existence of a c-Myb-Bmi1 transcription-regulatory pathway required for p190(BCR/ABL) leukemogenesis.
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Shape transition in Pt-nuclei with mass A ∼190
International Nuclear Information System (INIS)
Chamoli, S.K.
2017-01-01
The nuclei in mass region A ∼190 are well known for the prolate-oblate shape co-existence/transition phenomena. The shape coexistence phenomena has been observed in nuclei like Hg and Tl of this mass region. The calculations done for Pt nuclei in indicate a smooth shape change from prolate deformed "1"8"6Pt to nearly spherical "2"0"2"-"2"0"4 Pt through the region of triaxially deformed "1"8"8"-"1"9"8Pt and slightly oblate "2"0"0Pt. In these calculations, a change of shape from prolate to oblate is expected at A = 188. In recent high spin spectroscopic investigations, significant amount of reduced prolate collectivity has been observed in "1"8"8Pt. The level lifetimes provide valuable information about the nuclear shape and also the shape change with increase in spin along a band. So, to get clear signature of prolate to oblate shape inversion in Pt nuclei near A = 190, it is required to perform lifetime measurements. With this objective, the RDM lifetime measurements of high spin states have been done for various even-even Pt isotopes with masss A ≤ 186 over the years. The results obtained in these measurements are very encouraging and do indicate changing nuclear structure for Pt-isotopes with increasing mass at low spins. A gradual increase in B(E2) values upto 4"+ state and near constant nature there after in "1"8"8Pt, contrary to the other light neighboring Pt nuclei tends to indicate the volatile nature of deformation in Pt nuclei near A ∼ 190 which needs further theoretical investigations. (author)
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Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan.
Tabassum, Najia; Saboor, Mohammad; Ghani, Rubina; Moinuddin, Moinuddin
2014-07-01
Breakpoint cluster region-Abelson (BCR-ABL) rearrangement or Philadelphia (Ph) chromosome in Chronic Myeloid Leukemia (CML) is derived from a reciprocal chromosomal translocation between ABL gene on chromosome 9 and BCR gene on chromosome 22. This chimeric protein has various sizes and therefore different clinical behaviour. The purpose of this study was to determine the heterogeneity of BCR-ABL rearrangement in patients with Ph(+)CML in Pakistan. The study was conducted at Civil Hospital and Baqai Institute of Hematology (BIH) Karachi. Blood samples from 25 patients with CML were collected. Multiplex reverse transcription polymerase chain reaction (RT-PCR) was performed to identify various BCR-ABL transcripts. All 25 samples showed BCR-ABL rearrangements. Out of these, 24 (96%) patients expressed p210 BCR-ABL rearrangements i.e. 60% (n=15) had b3a2 and 32% (n=8) had b2a2 rearrangements. Co-expression of b3a2 /b2a2 rearrangement and p190 (e1a3) rearrangement was also identified in two patients. It is apparent that majority of the patients had p210 BCR-ABL rearrangements. Frequency of co-expression and rare fusion transcripts was very low.
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2010-07-01
... when standard levels of service are performed by other customer agencies? 102-85.190 Section 102-85.190... perform or contract for such services must be obtained in advance by the customer agency from the... of Service § 102-85.190 Can GSA Rent be adjusted when standard levels of service are performed by...
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The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study.
Kim, Hyun Tae; Kim, Joon Mo; Kim, Jung Hoon; Lee, Mi Yeon; Won, Yu Sam; Lee, Jae Yeun; Park, Ki Ho
2016-12-01
To investigate the relationship between vitamin D and glaucoma. This retrospective, cross-sectional study included subjects who underwent a health screening at the Health Screening Center of Kangbuk Samsung Hospital from August 2012 to July 2013. All fundus photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye was glaucomatous based on the criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and by the appearance of the retinal nerve fiber layer and optic disc. If the subjects previously underwent an ophthalmologic examination, they were enrolled based on the documented history. In addition to fundus photographs, each participant underwent a systemic examination including blood sampling and sociodemographic and behavioral questionnaires. The subjects were divided into five groups according to serum 25-hydroxyvitamin D (25(OH)D) level. Multivariate logistic regression models were constructed to assess possible associations between elevated glaucoma risk and systemic factors with a p < 0.2 on univariate analysis. Of the 169,208 subjects older than 20 years, 123,331 were eligible for the study. There was no difference in the prevalence of glaucoma according to quintile of serum 25(OH)D level based on sex ( p = 0.412 for males, p = 0.169 for females). According to the multivariable-adjusted logistic analysis, the odds ratio of glaucoma for the fourth quintile was significantly lower than that of the first quintile in females (odds ratio, 0.713; 95% confidence interval, 0.520 to 0.979). Lower 25(OH)D level was significantly associated with an elevated risk of glaucoma in females compared with higher 25(OH)D level. Further evaluation is needed to investigate the relationship between glaucoma and vitamin D.
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27 CFR 19.742 - Tank record of wine or spirits of less than 190 degrees of proof.
2010-04-01
... Records and Reports Storage Account § 19.742 Tank record of wine or spirits of less than 190 degrees of... wine or spirits of less than 190 degrees of proof to show deposits into, withdrawals from, and the...; (3) Identification of the tank; (4) Kind of wine or spirits; (5) Number and average proof gallon...
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49 CFR 190.319 - Petitions for extension of time to comment.
2010-10-01
... the time for petitioner's comments. A petition is granted only if the petitioner shows good cause for... 49 Transportation 3 2010-10-01 2010-10-01 false Petitions for extension of time to comment. 190... AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE...
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High density plasma gun generates plasmas at 190 kilometers per second
Espy, P. N.
1971-01-01
Gun has thin metal foil disc which positions or localizes gas to be ionized during electrical discharge cycle, overcoming major limiting factor in obtaining such plasmas. Expanding plasma front travels at 190 km/sec, compared to plasmas of 50 to 60 km/sec previously achieved.
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International Nuclear Information System (INIS)
Brengle, T.A.; Maron, N.
1980-01-01
Results are presented of comparative timing tests made by running a typical FORTRAN physics simulation code on the following machines: DEC PDP-10 with KI processor; DEC PDP-10, KI processor, and FPS AP-190L; CDC 7600; and CRAY-1. Factors such as DMA overhead, code size for the AP-190L, and the relative utilization of floating point functional units for the different machines are discussed. 1 table
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40 CFR 725.190 - Notice of commencement of manufacture or import.
2010-07-01
... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Notice of commencement of manufacture... Microbial Commercial Activities Notification Requirements § 725.190 Notice of commencement of manufacture or import. (a) Applicability. Any person who commences the manufacture or import of a new microorganism for...
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Analytical performance of centrifuge-based device for clinical chemistry testing.
Suk-Anake, Jamikorn; Promptmas, Chamras
2012-01-01
A centrifuge-based device has been introduced to the Samsung Blood Analyzer (SBA). The verification of this analyzer is essential to meet the ISO15189 standard. Analytical performance was evaluated according to the NCCLS EP05-A method. The results of plasma samples were compared between the SBA and a Hitachi 917 analyzer according to the NCCLS EP09-A2-IR method. Percent recovery was determined via analysis of original control serum and spiked serum. Within-run precision was found to be 0.00 - 6.61% and 0.96 - 5.99% in normal- and abnormal-level assays, respectively, while between-run precision was 1.31 - 9.09% and 0.89 - 6.92%, respectively. The correlation coefficients (r) were > 0.990. The SBA presented analytical accuracy at 96.64 +/- 3.39% to 102.82 +/- 2.75% and 98.31 +/- 4.04% to 103.61 +/- 8.28% recovery, respectively. The results obtained verify that all of the 13 tests performed using the SBA demonstrates good and reliable precision suitable for use in qualified clinical chemistry laboratory service.
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Using the DP-190 glue for adhesive attachment of a large space mirror and its rim
Vlasenko, Oleg; Zverev, Alexey; Sachkov, Mikhail
2014-07-01
The glue DP-190 is widely used for adhesive attachment of astrositall (zerodur) lightweight large-size space astronomical mirrors (diameter of 1.7 m and more) with elements of their frames of invar. Peculiarities of physicalmechanical behavior of the glue DP-190 when exposed to the environment during the ground operation and in orbit cause instability of the reflective surface quality of mirrors. In this report we show that even a small (around 1%-5%) volumetric deformation of a cylindrical adhesive layer with a thickness of 0.8 mm between the mirror and the rim element causes significant mirrors deformation. We propose to use adhesive layer of special form that allows to reduce volumetric deformations of the glue DP-190 up to three times. Here we present results based on primary mirror tests of the WSO-UV project.
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Thermionics. A bibliography with abstracts. Search period covered: 1970--Apr 1975. [190 references
Energy Technology Data Exchange (ETDEWEB)
Grooms, D.W.
1975-04-01
Research on thermionic power generation, power plant design, converter design, and basic research on thermionic materials are cited in the bibliography. Spacecraft applications are included. (Contains 190 abstracts).
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A Study of the 190 keV Transition in {sup 141}La
Energy Technology Data Exchange (ETDEWEB)
Berg, V; Hoeglund, Aa [Inst. of Physics, Univ. of Stockholm (Sweden); [AB Atome nergi, Nykoping (Sweden); Fogelberg, B [Inst. of Physics, Uppsala Univ. (Sweden)
1970-05-15
The gamma-ray spectrum from the decay of 18 min 141 Ba has been studied. Seventeen transitions were found below 900 keV, with energies and (intensities) as follows: 112.9{+-}0.2(3.0), 163.1{+-}0.3 (1.0), 165.7{+-}0.4(0.7), 180.5{+-}0.2(0.9), 190.3{+-}0.1(100), 276.9{+-}0.1 (52.2), 304.2{+-}0.1(55.8), 343.6{+-}0.1(30.8), 364.4{+-}0.6(1.6), 389.7{+-}0.2(2.8), 457.7{+-}0.2(10.4), 462.3{+-}0.2(10.5), 467.3{+-}0.1(11.4), 625.1{+-}0.2(6.1), 647.9{+-}0.2(10.7), 739.1{+-}0.3(8.7), 876.5{+-}0.3(6.7). K- and L-shell conversion coefficients have been measured for the 190. 3 keV transition, yielding a multipolarity of M1 + < 8 % E2. Half-life measurements using delayed coincidence technique have given the following results: T{sub 1/2} (190 keV level) = 1.27 {sup +0.06}{sub -0.10} ns, T{sub 1/2} (304 keV level) < 200 ps, T{sub 1/2} (467 keV level) < 120 ps. A level scheme of {sup 141}La has been constructed, and the spin-parity assignments of the ground state and first excited state are discussed in terms of the shell model.
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The proton therapy nozzles at Samsung Medical Center: A Monte Carlo simulation study using TOPAS
Chung, Kwangzoo; Kim, Jinsung; Kim, Dae-Hyun; Ahn, Sunghwan; Han, Youngyih
2015-07-01
To expedite the commissioning process of the proton therapy system at Samsung Medical Center (SMC), we have developed a Monte Carlo simulation model of the proton therapy nozzles by using TOol for PArticle Simulation (TOPAS). At SMC proton therapy center, we have two gantry rooms with different types of nozzles: a multi-purpose nozzle and a dedicated scanning nozzle. Each nozzle has been modeled in detail following the geometry information provided by the manufacturer, Sumitomo Heavy Industries, Ltd. For this purpose, the novel features of TOPAS, such as the time feature or the ridge filter class, have been used, and the appropriate physics models for proton nozzle simulation have been defined. Dosimetric properties, like percent depth dose curve, spreadout Bragg peak (SOBP), and beam spot size, have been simulated and verified against measured beam data. Beyond the Monte Carlo nozzle modeling, we have developed an interface between TOPAS and the treatment planning system (TPS), RayStation. An exported radiotherapy (RT) plan from the TPS is interpreted by using an interface and is then translated into the TOPAS input text. The developed Monte Carlo nozzle model can be used to estimate the non-beam performance, such as the neutron background, of the nozzles. Furthermore, the nozzle model can be used to study the mechanical optimization of the design of the nozzle.
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Systematic description of superdeformed bands in the mass-190 region
Energy Technology Data Exchange (ETDEWEB)
Sun, Yang; Guidry, M. [Oak Ridge National Lab., TN (United States)]|[Univ. of Tennessee, Knoxville, TN (United States); Zhang, Jing-ye [Univ. of Tennessee, Knoxville, TN (United States)
1996-12-31
Superdeformed bands for the mass-190 region are described by the Projected Shell Model. Even-even, odd mass and odd-odd nuclei are equally well described. Good agreement with available data for all isotopes studied is obtained. The authors calculation of electromagnetic properties and pairing correlations provides an understanding of the observed gradual increase of dynamical moments of inertia with angular momentum observed in many bands in this mass region.
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Optimization and validation of CEDIA drugs of abuse immunoassay tests in serum on Hitachi 912.
Kirschbaum, Katrin M; Musshoff, Frank; Schmithausen, Ricarda; Stockhausen, Sarah; Madea, Burkhard
2011-10-10
Due to sensitive limits of detection of chromatographic methods and low limit values regarding the screening of drugs under the terms of impairment in safe driving (§ 24a StVG, Street Traffic Law in Germany), preliminary immunoassay (IA) tests should be able to detect also low concentrations of legal and illegal drugs in serum in forensic cases. False-negatives should be avoided, the rate of false-positive samples should be low due to cost and time. An optimization of IA cutoff values and a validation of the assay is required for each laboratory. In a retrospective study results for serum samples containing amphetamine, methylenedioxy derivatives, cannabinoids, benzodiazepines, cocaine (metabolites), methadone and opiates obtained with CEDIA drugs of abuse reagents on a Hitachi 912 autoanalyzer were compared with quantitative results of chromatographic methods (gas or liquid chromatography coupled with mass spectrometry (GC/MS or LC/MS)). Firstly sensitivity, specificity, positive and negative predictive values and overall misclassification rates were evaluated by contingency tables and compared to ROC-analyses and Youden-Indices. Secondly ideal cutoffs were statistically calculated on the basis of sensitivity and specificity as decisive statistical criteria with focus on a high sensitivity (low rates of false-negatives), i.e. using the Youden-Index. Immunoassay (IA) and confirmatory results were available for 3014 blood samples. Sensitivity was 90% or more for nearly all analytes: amphetamines (IA cutoff 9.5 ng/ml), methylenedioxy derivatives (IA cutoff 5.5 ng/ml), cannabinoids (IA cutoff 14.5 ng/ml), benzodiazepines (IA cutoff >0 ng/ml). Test of opiates showed a sensitivity of 86% for a IA cutoff value of >0 ng/ml. Values for specificity ranged between 33% (methadone, IA cutoff 10 ng/ml) and 90% (cocaine, IA cutoff 20 ng/ml). Lower cutoff values as recommended by ROC analyses were chosen for most tests to decrease the rate of false-negatives. Analyses enabled
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Utilities for developing HITAC 10-2 program with U-400 and M-190 systems
International Nuclear Information System (INIS)
Tsuda, Kenzo.
1979-06-01
At the time of developing ''On-line experimental data processing system for JIPP (Japan Institute of Plasma Physics) T-2'', a number of utilities have been developed, which can develop the programs on the HITAC 10-2 side through the PANAFACOM U-400 and the FACOM M-190 computer systems. The HITAC 10-2 is a computer mainly composed of core memories, whose performances of processing speed, peripherals and softwares are considerably different from large and medium size computers. For this reason, it requires tremendous time and labor to develop large scale programs or systems by utilizing only the HITAC 10-2. Accordingly, some utilities have been developed with the U-400 and M-190 systems in order to shorten the developing time and improve the developing efficiency. In the example of above ''On-line experimental data processing system for JIPP T-2'', the time required for one debugging can be reduced to 20 minutes from former 5 to 6 hours. In this report, first, the program development by the HITAC 10-2, and next, the bind processing with U-400 and the cross-assembling with M-190 are described. Then the functions and the method for use of the utilities are explained. (Wakatsuki, Y.)
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Kim, Sun-Young; Shin, Dong-Won; Oh, Kang-Seob; Kim, Eun-Jin; Park, Yang-Ri; Shin, Young-Chul; Lim, Se-Won
2018-02-01
In this study, the relationship between occupational stress and suicidal ideation was investigated, focusing on gender differences among Korean employees. Cross-sectional data for 53,969 workers were collected at Kangbuk Samsung Hospital health screening centers. Risk of suicidal ideation was assessed using a self-reported questionnaire examining suicidal ideation during the past year. Occupational stress was measured using 24 items of the Korean Occupational Stress Scale-Short Form (KOSS-SF). Logistic regression analysis was employed to estimate the odds ratios and 95% confidence intervals of the relationships between suicidal ideation and components of occupational stress. In multivariable-adjusted models, all job stress contributed to increased risk of suicidal ideation in males. Most subscales, except insufficient job control and organizational system, were risk factors of suicidal ideation in females. Further adjustments for depression markedly attenuated this relationship. However, the effects of insufficient job control and lack of reward on suicidal ideation remained significant in males, and interpersonal conflict remained significant in females. The results suggest that occupational stress plays a significant role in increasing risk of suicidal ideation through elevation of depressive symptoms. Gender differences in components of occupational stress associated with suicidal ideation were also observed.
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The uses of the smartphone for doctors: an empirical study from samsung medical center.
Choi, Jong Soo; Yi, Byoungkee; Park, Jong Hwan; Choi, Kyesook; Jung, Jaegon; Park, Seung Woo; Rhee, Poong-Lyul
2011-06-01
In healthcare, mobile computing made possible by smartphones is becoming an important tool among healthcare professionals. However, currently there is very little research into the effectiveness of such applications of technology. This study aims to present a framework for a smartphone application to give doctors mobile access to patient information, then review the consequences of its use and discuss its future direction. Since 2003 when Samsung Medical Center introduced its first mobile application, a need to develop a new application targeting the latest smartphone technology was identified. To that end, an application named Dr. SMART S was officially launched on December 22nd, 2010. We analyzed the usage data of the application for a month until April 25th, 2011. On average, 170 doctors (13% of the entire body of doctors) logged on 2.4 times per day and that number keeps growing. The number was uniformly distributed across all working hours, with exceptions of heavy accesses around 6-8 AM and 4-6 PM when doctors do their regular rounds to see the patients. The most commonly accessed content was inpatient information, this constituted 78.6% of all accesses, within this 50% was to accesses lab results. Looking at the usage data, we can see the use of Dr. SMART S by doctors is growing in sync with the popularity of smartphones. Since u-Health seem an inevitable future trend, a more rigorous study needs to be conducted on how such mobile applications as Dr. SMART S affect the quality of care and patient safety to derive directions for further improvements.
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2011-07-15
... investigation named numerous respondents, including Samsung Electronics Co., Ltd. of Seoul, South Korea (``Samsung''); Samsung Electronics America, Inc. of Ridgefield Park, New Jersey, Samsung International, Inc. of San Diego, California, Samsung Semiconductor, Inc. of San Jose, California, and Samsung...
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Estevez Aguado, M.E.; Agramunt, J.; Rubio, B.; Tain, J.L.; Jordan, D.; Fraile, L.M.; Gelletly, W.; Frank, A.; Csatlos, M.; Csige, L.; Dombradi, Zs.; Krasznahorkay, A.; Nacher, E.; Sarriguren, P.; Borge, M.J.G.; Briz, J.A.; Tengblad, O.; Molina, F.; Moreno, O.; Kowalska, M.; Fedosseev, V.N.; Marsh, B.A.; Fedorov, D.V.; Molkanov, P.L.; Andreyev, A.N.; Seliverstov, M.D.; Burkard, K.; Huller, W.
2015-01-01
The beta decay of $^{192,190}$Pb has been studied using the total absorption technique at the ISOLDE(CERN) facility. The beta-decay strength deduced from the measurements, combined with QRPA theoretical calculations, allow us to infer that the ground states of the $^{192,190}$Pb isotopes are spherical. These results represent the first application of the shape determination method using the total absorption technique for heavy nuclei and in a region where there is considerable interest in nuclear shapes and shape effects.
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Infants 1-90 days old hospitalized with human rhinovirus infection.
Bender, Jeffrey M; Taylor, Charla S; Cumpio, Joven; Novak, Susan M; She, Rosemary C; Steinberg, Evan A; Marlowe, Elizabeth M
2014-09-01
Human rhinovirus (HRV) is a common cause of respiratory illness in children. The impact of HRV infection on 1- to 90-day-old infants is unclear. We hypothesized that HRV infection would be clinically similar to respiratory syncytial virus (RSV) infection in the hospitalized infants. We conducted a retrospective study of hospitalized infants, who were 1-90 days old, with HRV or RSV within the Southern California Kaiser Permanente network over a 1-year period (August 2010 to October 2011). We identified 245 hospitalized infants who underwent respiratory virus testing. HRV was found in 52 infants (21%) compared to 79 infants (32%) with RSV (P = 0.008). Infants with HRV infection experienced longer hospital stays compared to those with RSV (median length of stay 4 days vs. 3 days, P = 0.009) and had fewer short hospital stays ≤3 days (P = 0.029). There was a trend in infants with HRV infection to be younger (P = 0.071) and have more fevers (P = 0.052). Recent advances in diagnostics allow for identification of a broad range of viral pathogens in infants. Compared to RSV, HRV was associated with longer hospital stays. Additional studies and improved, more specific testing, methods are needed to further define the effects of HRV infection in infants 1-90 days old. © 2014 Wiley Periodicals, Inc.
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Energy Technology Data Exchange (ETDEWEB)
Santos, Julio A. dos; Mól, Antônio C. de A.; Santo, André C. Do E., E-mail: julio_andrade11@hotmail.com [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Centro Universitário Carioca (UniCarioca), Rio de Janeiro, RJ (Brazil)
2017-07-01
Radioactive waste is all material resulting from human activity that contains elements that emit radiation that can generate risks to health and the environment. In this sense, they are very toxic also for those who perform the storage of radioactive waste in nuclear facilities. On the other hand, the virtual reality (VR) has been destined to the most diverse purposes, like simulations for educational systems, for military purposes as for diverse training. VR can be considered as the junction of three basic principles: immersion, interaction and involvement. Bases on these principles of VR, this work aimed to develop a simulator of a repository of nuclear tailings, for mobile computing, whose interaction interface will be through the Samsung Gear VR helmet. The simulator of the nuclear waste repository was developed in the unity 3D tool and the elements that make up the scenario in the 3D MAX program. In this work we tried to put virtual reality under scrutiny in conjunction with Gear VR, to help in the sensation of immersion, as well as, the possibility of interaction with joysticks. The purpose was to provide greater insight into the operating environment. (author)
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International Nuclear Information System (INIS)
Santos, Julio A. dos; Mól, Antônio C. de A.; Santo, André C. Do E.
2017-01-01
Radioactive waste is all material resulting from human activity that contains elements that emit radiation that can generate risks to health and the environment. In this sense, they are very toxic also for those who perform the storage of radioactive waste in nuclear facilities. On the other hand, the virtual reality (VR) has been destined to the most diverse purposes, like simulations for educational systems, for military purposes as for diverse training. VR can be considered as the junction of three basic principles: immersion, interaction and involvement. Bases on these principles of VR, this work aimed to develop a simulator of a repository of nuclear tailings, for mobile computing, whose interaction interface will be through the Samsung Gear VR helmet. The simulator of the nuclear waste repository was developed in the unity 3D tool and the elements that make up the scenario in the 3D MAX program. In this work we tried to put virtual reality under scrutiny in conjunction with Gear VR, to help in the sensation of immersion, as well as, the possibility of interaction with joysticks. The purpose was to provide greater insight into the operating environment. (author)
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Isomers in neutron-rich A ∼ 190 nuclides from 208Pb fragmentation
International Nuclear Information System (INIS)
Rykaczewski, Krzysztof Piotr; Caamano, M.; Banu, A.; Walker, P.M.; Morton, N.H.; Regan, P. H.; Regan, Patrick H; Pfutzner, M.; Podolyak, Zs.; Gerl, J.; Hellstrom, M.; Mayet, P.; Miernik, K.; Mineva, M.N.; Aprahamian, A.; Benlliure, J.; Bruce, A.M.; Butler, P.A.; Cortina Gil, D.; Cullen, D.M.; Doring, J.; Enqvist, T.; Fox, C.; Garces Narro, J.; Geissel, H.; Gelletly, W.; Giovinazzo, J.; Gorska, M.; Grawe, H.; Grzywacz, R.; Kleinbohl, A.; Korten, W.; Lewitowicz, M.; Lucas, R.; Mach, H.; O'Leary, C.D.; De Oliveira, F.; Pearson, C.J.; Rejmund, F.
2004-01-01
Relativistic projectile fragmentation of 208 Pb has been used to produce isomers in neutron-rich, A ∼ 190 nuclides. A forward-focusing spectrometer provided ion-by-ion mass and charge identification. The detection of gamma-rays emitted by stopped ions has led to the assignment of isomers in 188 Ta, 190 W, 192 Re, 193 Re, 195 Os, 197 Ir, 198 Ir, 200 Pt, 201 Pt, 202 Pt and 203 Au, with half-lives ranging from approximately 10 ns to 1 ms. Tentative isomer information has been found also for 174 Er, 175 Er, 185 Hf, 191 Re, 194 Re and 199 Ir. In most cases, time-correlated, singles gamma-ray events provided the first spectroscopic data on excited states for each nuclide. In 200 Pt and 201 Pt, the assignments are supported by gamma-gamma coincidences. Isomeric ratios provide additional information, such as half-life and transition energy constraints in particular cases. The level structures of the platinum isotopes are discussed, and comparisons are made with isomer systematics
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Lafi, Feras Fawzi
2016-12-23
Pseudomonas argentinensis strain SA190 is a plant endophytic-inhabiting bacterium that was isolated from root nodules of the desert plant Indigofera argentea collected from the Jizan region of Saudi Arabia. Here, we report the genome sequence of SA190, highlighting several functional genes related to plant growth-promoting activity, environment adaption, and antifungal activity.
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Hung, Tzu-Min; Ho, Cheng-Maw; Liu, Yen-Chun; Lee, Jia-Ling; Liao, Yow-Rong; Wu, Yao-Ming; Ho, Ming-Chih; Chen, Chien-Hung; Lai, Hong-Shiee; Lee, Po-Huang
2014-01-01
Background & Aims Insulin-like growth factor, (IGF)-1, is produced mainly by the liver and plays important roles in promoting growth and regulating metabolism. Previous study reported that development of hepatocellular carcinoma (HCC) was accompanied by a significant reduction in serum IGF-1 levels. Here, we hypothesized that dysregulation of microRNAs (miRNA) in HCC can modulate IGF-1 expression post-transcriptionally. Methods The miRNAs expression profiles in a dataset of 29 HCC patients were examined using illumina BeadArray. Specific miRNA (miR)-190b, which was significantly up-regulated in HCC tumor tissues when compared with paired non-tumor tissues, was among those predicted to interact with 3′-untranslated region (UTR) of IGF-1. In order to explore the regulatory effects of miR-190b on IGF-1 expression, luciferase reporter assay, quantitative real-time PCR, western blotting and immunofluorecence analysis were performed in HCC cells. Results Overexpression of miR-190b in Huh7 cells attenuated the expression of IGF-1, whereas inhibition of miR-190b resulted in up-regulation of IGF-1. Restoration of IGF-1 expression reversed miR-190b-mediated impaired insulin signaling in Huh7 cells, supporting that IGF-1 was a direct and functional target of miR-190b. Additionally, low serum IGF-1 level was associated with insulin resistance and poor overall survival in HCC patients. Conclusions Increased expression of miR-190 may cause decreased IGF-1 in HCC development. Insulin resistance appears to be a part of the physiopathologic significance of decreased IGF-1 levels in HCC progression. This study provides a novel miRNA-mediated regulatory mechanism for controlling IGF-1 expression in HCC and elucidates the biological relevance of this interaction in HCC. PMID:24586785
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Photoreduction of Carbon Dioxide to Methane Over Sb1.5Sn8.5-x Ti x O19.0 with High Conductivity.
Do, Jeong Yeon; Kwak, Byeong Sub; Kang, Misook
2018-09-01
In order to enhance the photoreduction of CO2 to CH4, a new type of photocatalyst, Sb1.5Sn8.5-xTixO19.0, with high conductivity and low bandgap was developed by partially incorporating Ti into the framework of Sb1.5Sn8.5O19.0 (antimony-doped tin oxide, ATO) using a controlled hydrothermal method. XRD and TEM analyses indicated that the Sb1.5Sn8.5-xTixO19.0 particles exhibited a tetragonal crystal structure and were approximately 20 nm in size. Furthermore, the bandgap and conductivity of these materials increased with increasing Ti content. A study of the photoreduction of CO2 with H2O revealed a remarkable increase in the generation of CH4 over the Sb1.5Sn8.5-xTixO19.0 catalysts. In particular, CH4 generation was the highest when Sb1.5Sn8.5Ti1.0O19.0 was used as the photocatalyst, and was three-fold higher than that achieved by using anatase TiO2. Photoluminescence studies showed that the enhanced photocatalytic activity of the Sb1.5Sn8.5-xTixO19.0 materials could be attributed to the interfacial transfer of photogenerated charges, which led to an effective charge separation and inhibition of the recombination of photogenerated electron-hole (e-/h+) pairs.
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International Nuclear Information System (INIS)
Waetzig, W.
1980-01-01
Using the reaction 197 Au( 3 He,xn) Tl the decay of the nuclides 188 Tl and 190 Tl to 188 Hg (Tsub(1/2) = 70s) respectively to 190 Hg(Tsub(1/2) = 3.0 min) was studied at the mass separator ISOCELE of the Orsay-synchrocyclotron by gamma, conversion electron, gamma-gamma coincidence, and electron-gamma coincidence spectroscopy. The level schemes of 188 Hg and 190 Hg could be remarkably extended in comparison with earlier works. By a statistical analysis of the nuclear level density the nuclear temperature was calculated as a measure for the number of excitation modes of these nuclei. (orig./HSI) [de
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A new color image encryption scheme using CML and a fractional-order chaotic system.
Directory of Open Access Journals (Sweden)
Xiangjun Wu
Full Text Available The chaos-based image cryptosystems have been widely investigated in recent years to provide real-time encryption and transmission. In this paper, a novel color image encryption algorithm by using coupled-map lattices (CML and a fractional-order chaotic system is proposed to enhance the security and robustness of the encryption algorithms with a permutation-diffusion structure. To make the encryption procedure more confusing and complex, an image division-shuffling process is put forward, where the plain-image is first divided into four sub-images, and then the position of the pixels in the whole image is shuffled. In order to generate initial conditions and parameters of two chaotic systems, a 280-bit long external secret key is employed. The key space analysis, various statistical analysis, information entropy analysis, differential analysis and key sensitivity analysis are introduced to test the security of the new image encryption algorithm. The cryptosystem speed is analyzed and tested as well. Experimental results confirm that, in comparison to other image encryption schemes, the new algorithm has higher security and is fast for practical image encryption. Moreover, an extensive tolerance analysis of some common image processing operations such as noise adding, cropping, JPEG compression, rotation, brightening and darkening, has been performed on the proposed image encryption technique. Corresponding results reveal that the proposed image encryption method has good robustness against some image processing operations and geometric attacks.
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Exotic superdeformed structure in A∼190 nuclei observed using Eurogam2
International Nuclear Information System (INIS)
Wilson, A.N.; Timar, J.; Bergstroem, M.; Paul, E.S.; Bouneau, S.; Azaiez, F.; Korichi, A.; Nakatsukasa, T.
1995-01-01
Dipole transitions between superdeformed rotational bands are only very rarely observed due to the competition from the very strong in-band E2 decays. We have carried out two experiments with the EUROGAM2 γ-ray spectrometer, situated at the Vivitron tandem accelerator at CRN Strasbourg, in September and October 1994. In the first experiment we observe M1 dipole transitions between the signature partner yrast superdeformed bands in 193 Tl. This measurement gives a mean value of (g K -g R ) K/Q o = 0.135 ± 0.010 μ N /eb identifying the bands as belonging to the (642)5/2 single particle orbital. We also observe 5 additional new superdeformed bands in 193 Tl, whose structures are discussed. In the second experiment we observe three transitions, at 911, 865 and 831 keV, which link an excited superdeformed band in 190 Hg to the yrast superdeformed band. The data suggest that these are stretched dipole transitions with E1 multipolarity and strengths of about 10 -3 Wu. This is the first observation of a collective vibration of the superdeformed mean field. We also observe two new superdeformed bands in 190 Hg. (authors). 39 refs., 11 figs., 3 tabs
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The alpha-branching ratios of the 188,190,192Pb isotopes
International Nuclear Information System (INIS)
Wauters, J.; Dendooven, P.; Decrock, P.; Huyse, M.; Reusen, G.; Duppen, P. van
1992-01-01
The α-branching ratios (b α ) of 192,190,188 Pb are measured using mass-separated sources. Different experimental set-ups are used - one detector as well as two detector set-ups - thereby detecting the α particles from the parent and/or via α decay formed daughter nuclei, the β-delayed gamma radiation from the parent and/or via β decay formed daughter nuclei in the Tl KX Rays from electron capture decay. Values for b α of 6.2(6) 10 -5 and 4.0(4) 10 -3 were found for 191,190 Pb respectively. For 188 Pb, limits on the b α values were obtained: 0.03 α α values showed that the discrepancies in the b α values were not due to inadequate correction procedures, as was suggested, but to experimental uncertainties in the efficiency determination of the different detection set-ups and to an unreliable β-decay scheme for 188 Pb. The b α obtained in this work show that the lead α decay is not faster than the Hg α decay and that there is no need to assume a disappearance of the Z=82 shell closure halfway between N=82 and N=126. (orig.)
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46 CFR 190.07-90 - Vessels contracted for prior to March 1, 1968.
2010-10-01
... considered satisfactory so long as they are maintained in good condition to the satisfaction of the Officer in Charge, Marine Inspection. Minor repairs and alterations may be made to the same standards as the... VESSELS CONSTRUCTION AND ARRANGEMENT Structural Fire Protection § 190.07-90 Vessels contracted for prior...
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Quantification of dsDNA using the Hitachi F-7000 Fluorescence Spectrophotometer and PicoGreen dye.
Moreno, Luis A; Cox, Kendra L
2010-11-05
Quantification of DNA, especially in small concentrations, is an important task with a wide range of biological applications including standard molecular biology assays such as synthesis and purification of DNA, diagnostic applications such as quantification of DNA amplification products, and detection of DNA molecules in drug preparations. During this video we will demonstrate the capability of the Hitachi F-7000 Fluorescence Spectrophotometer equipped with a Micro Plate Reader accessory to perform dsDNA quantification using Molecular Probes Quant-it PicoGreen dye reagent kit. The F-7000 Fluorescence Spectrophotometer offers high sensitivity and high speed measurements. It is a highly flexible system capable of measuring fluorescence, luminescence, and phosphorescence. Several measuring modes are available, including wavelength scan, time scan, photometry and 3-D scan measurement. The spectrophotometer has sensitivity in the range of 50 picomoles of fluorescein when using a 300 μL sample volume in the microplate, and is capable of measuring scan speeds of 60,000 nm/minute. It also has a wide dynamic range of up to 5 orders of magnitude which allows for the use of calibration curves over a wide range of concentrations. The optical system uses all reflective optics for maximum energy and sensitivity. The standard wavelength range is 200 to 750 nm, and can be extended to 900 nm when using one of the optional near infrared photomultipliers. The system allows optional temperature control for the plate reader from 5 to 60 degrees Celsius using an optional external temperature controlled liquid circulator. The microplate reader allows for the use of 96 well microplates, and the measuring speed for 96 wells is less than 60 seconds when using the kinetics mode. Software controls for the F-7000 and Microplate Reader are also highly flexible. Samples may be set in either column or row formats, and any combination of wells may be chosen for sample measurements. This allows
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2012-12-19
... investigation named Samsung Electronics Co., Ltd. of Gyeonggi-do, Korea; Samsung LED Co., Ltd. of Gyeonggi Province, Korea; Samsung Electronics America, Inc. of Ridgefield Park, New Jersey; Samsung LED America, Inc. of Atlanta, Georgia (collectively, ``Samsung''); and LG as respondents. No Commission investigative...
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2013-01-31
.... Sec. 1337, on behalf of Samsung Electronics Co., Ltd., Seoul, Republic of Korea and Samsung... complainants are: Samsung Electronics Co., Ltd., Samsung Main Building, 250, Taepyung-ro 2-ka, Chung-ku, Seoul 100-742, Republic of Korea. Samsung Telecommunications America, LLC, 1301 East Lookout Drive...
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International Nuclear Information System (INIS)
1982-03-01
Uranium Milling operations are licensed by the Nuclear Regulatory Commission and by some States in agreement with the Commission. The radiation dose to any individual from the operation of facilities within the uranium fuel cycle is limited to levels set by the Environmental Protection Agency. These levels are contained in the EPA Environmental Radiation Protection Standards for Nuclear Power Operations, in Part 190 of Title 40 of the Code of Federal Regulations (40 CFR Part 190). This report describes the procedures used within NRC's Uranium Recovery Licensing Branch for evaluating compliance with these regulations for uranium milling operations. The report contains descriptions of these procedures, dose factors for evaluating environmental measurement data, and guidance to the NRC staff reviewer
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2011-10-17
...: Samsung Electronics Co., Ltd. of Gyeonggi-do, Korea; Samsung LED Co., Ltd. of Gyeonggi Province, Korea; Samsung Electronics America, Inc. of Ridgefield Park, New Jersey; Samsung LED America, Inc. of Atlanta... corporate name change from OSRAM GmbH to OSRAM AG, to correct the addresses of Samsung Electronics Co., Ltd...
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International Nuclear Information System (INIS)
Alfred Wickline
2008-01-01
This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 190, Contaminated Waste Sites, Nevada Test Site, Nevada, in accordance with the Federal Facility Agreement and Consent Order that was agreed to by the State of Nevada; U.S. Department of Energy, Environmental Management; U.S. Department of Defense; and DOE, Legacy Management (1996, as amended January 2007). Corrective Action Unit 190 is comprised of the following four corrective action sites (CASs): (1) 11-02-01, Underground Centrifuge; (2) 11-02-02, Drain Lines and Outfall; (3) 11-59-01, Tweezer Facility Septic System; (4) 14-23-01, LTU-6 Test Area The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 190 with no further corrective action. To achieve this, corrective action investigation (CAI) activities were performed from March 21 through June 26, 2007. All CAI activities were conducted as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 190: Contaminated Waste Sites, Nevada Test Site, Nevada (NNSA/NSO, 2006). The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 190 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling the data quality objective data needs
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Ylönen, Raimo
2009-01-01
TM võrdleb mobiiltelefone hinnaga 500-2000 krooni: Nokia 1650, Nokia 3110 classic, Nokia 3120 classic, Nokia 5030 XpressRadio, Nokia 5130 XpressMusic, Nokia 7070 Prism, Samsung SGH-B100, Samsung SGH-C260, Samsung SGH-J400, Samsung SGH-M110, Samsung SGH-M310, Sony Ericsson T280i, Sony Ericsson W302
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2012-11-16
... electronic digital media devices and components thereof imported by respondents Samsung Electronics Co, Ltd. of Korea; Samsung Electronics America, Inc. of Ridgefield Park, New Jersey; and Samsung Telecommunications America, LLC of Richardson, Texas (collectively ``Samsung''), and cease and desist orders against...
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Predicting superdeformed rotational band-head spin in A ∼ 190 ...
Indian Academy of Sciences (India)
Table1 Shi2 ab3. Becker4 CBM5 SAM6 Zeng7. 191Au(b1). 187. 184.6. 1.5. 0.1185. 9.5. 9.5. 7.5. 7.5. –. 7.5. 7.5. 7.5. 191Au(b2). 398. 398.7. 8.4. 0.0928. 17.5. 17.5 17.5. 17.5. –. 17.5. 17.5 17.5. 191Au(b3). 383. 383.3. 7.4. 0.0916. 16.5. 16.5 17.5. 17.5. –. 16.5. 16.5 16.5. 190Hg(b1). 317. 316.8. 6.8. 0.0834. 12. 12. 13. 13. 12.
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Rhee, Eun-Jung; Cho, Jung-Hwan; Kwon, Hyemi; Park, Se Eun; Park, Cheol-Young; Oh, Ki-Won; Park, Sung-Woo; Lee, Won-Young
2017-12-01
The hemoglobin glycation index (HGI) is known to be correlated with the risk for cardiovascular disease. To analyze the association between incident coronary artery calcification (CAC) and the changes in HGI among participants without diabetes, over 4 years. A retrospective study of 2052 nondiabetic participants in whom the coronary artery calcium score was measured repeatedly over 4 years, as part of a health checkup program in Kangbuk Samsung Hospital in Korea, and who had no CAC at baseline. The HGI was defined as the difference between the measured and predicted hemoglobin A1c (HbA1c) levels. A total of 201 participants developed CAC after 4 years, and the mean baseline HGI was significantly higher in those patients. The incidence of CAC gradually increased from the first to the fourth quartile groups of baseline HGI. The odds ratio (OR) for incident CAC was the highest among the four groups divided by the quartiles of the baseline HGI and was significant after adjustment for confounding variables (vs first quartile group: OR, 1.632; 95% confidence interval, 1.024 to 2.601). The incidence of and risk for CAC development were significantly higher than in other groups compared with the low-to-low group after adjustment for confounding factors; however, when baseline HbA1c level was included in the model, only participants with a low-to-high HGI over 4 years showed a significantly increased OR for CAC development compared with the low-to-low group (OR, 1.722; 95% confidence interval, 1.046 to 2.833). The participants with a high baseline HGI and consistently high HGI showed a higher risk for incident CAC than those with a low baseline HGI. An increased HGI over 4 years significantly increased the risk for CAC regardless of the baseline HbA1c levels. Copyright © 2017 Endocrine Society
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2013-01-29
... a domestic industry. The respondents named in the Commission's notice of investigation are Samsung Electronics Co, Ltd. of Korea; Samsung Electronics America, Inc. of Ridgefield Park, New Jersey; and Samsung Telecommunications America, LLC of Richardson, Texas (collectively, ``Samsung''). A Commission investigative attorney...
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2011-07-11
... served: Samsung Electronics Co., Ltd., 416 Maetan-dong, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-742, Korea. Samsung Electronics America, Inc., 85 Challenger Road, Ridgefield Park, NJ 07660. Samsung LED Co., Ltd., 206, Cheomdansaneop Road, Yeongtong-gu, Suwon City, Gyeonggi Province 443-743, Korea. Samsung...
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2010-09-13
... served: Samsung Electronics Co., Ltd., 250, Taepyeongno 2-ga, Jung-gu, Seoul 100-742, South Korea. Samsung Electronics America, Inc., 105 Challenger Road, Ridgefield Park, NJ 07660. Samsung International, Inc., 10220 Sorrento Valley Road, San Diego, CA 92121. Samsung Semiconductor, Inc., 3655 North First...
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2011-06-09
... light- emitting diodes and products containing same. The complaint names as respondents Samsung Electronics Co., Ltd of Korea; Samsung Electronics America, Inc. of Ridgefield Park, NJ; Samsung LED Co., Ltd. of Korea and Samsung LED America, Inc. of Atlanta, GA. The complainant, proposed respondents, other...
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2012-06-05
...) investigation of washing machines from Korea.\\1\\ In the Initiation Notice, the Department selected Samsung Electronics Co., Ltd. (Samsung), LG Electronics, Inc. (LG), and Daewoo Electronics Corporation (Daewoo) as the..., 2012, the GOK, Samsung, and LG submitted their questionnaire responses. On April 13, 2012, Samsung...
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2010-03-18
... Conservation Program for Consumer Products: Decision and Order Granting a Waiver to Samsung Electronics America... (Case No. RF-011) that grants to Samsung Electronics America, Inc. (Samsung) a waiver from the DOE... humidity sensors and adaptive control anti-sweat heaters. Under today's decision and order, Samsung shall...
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2010-08-03
... Conservation Program for Consumer Products: Decision and Order Granting a Waiver to Samsung Electronics America...-014) that grants to Samsung Electronics America, Inc. (Samsung) a waiver from the DOE electric... decision and order, Samsung shall be required to test and rate these refrigerator- freezers equipped with...
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New isomers in the neutron-rich A∼190 mass region
International Nuclear Information System (INIS)
Caamano, M.
2002-02-01
Previously unobserved isomeric states in 188 Ta, 190 W, 192 Re, 193 Re, 195 Os, 197 Ir, 198 Ir, 200 Pt, 201 Pt, 202 Pt and 203 Au, with half-lives ranging from 10 ns to 290 μs have been populated and studied using a fragmentation reaction in conjunction with a forward focussing spectrometer. In most cases, this provided the first ever spectroscopic data made available for the nucleus, and 200 Pt presented the first new seniority 4 state, on the basis of γ-γ coincidences, following a fragmentation reaction. Half-lives have been measured and tentative level schemes have been drawn for each isomer, spins and parities being consistent with blocked BCS calculations, hindrance factors, systematics and the relative intensities of γ-rays and X-rays (where possible). Isomeric ratios have been measured, values ranging from 1 % to 64 %. Potential Energy Surface calculations were performed in parallel to the blocked BCS calculations, in order to provide deformation parameters, excitation energies and quasiparticle configurations. Ground state (or lowest level) shape calculations reveal a change from axially symmetric, through triaxial, to spherical shapes across the data set, from 188 Ta to 203 Au, as 208 Pb is approached. Weisskopf hindrance factors provide evidence for the erosion of the goodness of the K-quantum number, compatible with soft or axially symmetric shapes. The prolate-oblate phase transition region, with respect to tungsten, osmium and platinum, shows 195 Os to be the pivotal nucleus in the osmium isotopic chain, with a calculated triaxial ground state. On comparison with the systematics of the region, results obtained for 190 W show evidence for a Z ≤ 74 sub-shell closure, analogous to that at Z = 64. Finally, new isotopes, 167 Tb, 170 Dy and 199 Ir were discovered. (author)
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2011-04-28
... Samsung Electro-Mechanics Co., Ltd. of Suwon City, Korea and Samsung Electro- Mechanics America, Inc. of Irvine, California (collectively, ``Samsung'') as respondents. On December 22, 2010, the ALJ issued his... the ID. That same day, Samsung filed a contingent petition for review of the ID. On January 12, 2011...
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2012-09-10
... filed by Samsung LED Co., Ltd. of Suwon City, Korea, and Samsung LED America, Inc. of Atlanta, Georgia... Complaint and Notice of Investigation to substitute Samsung Electronics Co., Ltd. of Suwon City, Korea (``Samsung Electronics''), for the SLED complainants, as a result of corporate reorganization. On July 30...
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2015-05-20
Joint Oil Analysis Program Spectrometer Standards SCP Science (Conostan) Qualification Report For D19-0, D3-100, and D12- XXX Series Standards NF...Candidate Type D19-0 ICP-AES Results ..................................................................... 4 Table V. Candidate Type D12- XXX ...Physical Property Results .................................................. 5 Table VI. Candidate Type D12- XXX Rotrode-AES Results
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Lifetime measurements and dipole transition rates for superdeformed states in 190Hg
International Nuclear Information System (INIS)
Amro, H.
1999-01-01
The Doppler-shift attenuation method was used to measure life-times of superdeformed (SD) states for both the yrast and the first excited superdeformed band of 190 Hg. Intrinsic quadruple moments Q 0 were extracted. For the first time, the dipole transition rates have been extracted for the inter-band transitions which connect the excited SD band to the yrast states in the second minimum. The results support the interpretation of the excited SD band as a rotational band built on an octupole vibration
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Superdeformation in the A=150 and A=190 regions
International Nuclear Information System (INIS)
Carpenter, M. P.
1998-01-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in γ-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, ΔI = 4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well
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Superdeformation in the A=150 and A=190 regions.
Energy Technology Data Exchange (ETDEWEB)
Carpenter, M. P.
1998-12-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in {gamma}-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, {Delta}I = 4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well.
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International Nuclear Information System (INIS)
Chung, Kwang Zoo; Han, Young Yih; Kim, Jin Sung
2015-01-01
The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015
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Chung, Kwangzoo; Han, Youngyih; Kim, Jinsung; Ahn, Sung Hwan; Ju, Sang Gyu; Jung, Sang Hoon; Chung, Yoonsun; Cho, Sungkoo; Jo, Kwanghyun; Shin, Eun Hyuk; Hong, Chae-Seon; Shin, Jung Suk; Park, Seyjoon; Kim, Dae-Hyun; Kim, Hye Young; Lee, Boram; Shibagaki, Gantaro; Nonaka, Hideki; Sasai, Kenzo; Koyabu, Yukio; Choi, Changhoon; Huh, Seung Jae; Ahn, Yong Chan; Pyo, Hong Ryull; Lim, Do Hoon; Park, Hee Chul; Park, Won; Oh, Dong Ryul; Noh, Jae Myung; Yu, Jeong Il; Song, Sanghyuk; Lee, Ji Eun; Lee, Bomi; Choi, Doo Ho
2015-12-01
The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.
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Kim, D Y; Ahn, Y C; Oh, D G; Choi, D R; Ju, S G; Yeo, I H; Huh, S J
2000-09-01
A new collimator cone system has been developed at the Samsung Medical Center that overcomes some of the limitations of present commercially supplied collimator cones. The physical properties of the newly developed cone system are described in this report. The new cones have relatively larger aperture sizes (3.0-7.0 cm in diameter) and are 16 cm in length. Each new cone is fabricated with cerrobend alloy melted and poured into a stainless steel housing that is permanently fixed to a mounting plate. The mounting plate of the new cone is designed to insert into the wedge mount slot of the gantry head. The mechanical accuracy of the central axis of the cone pointing to the isocenter was tested using film, a steel ball positioned at the isocenter by the mechanical isocenter device. For the evaluation of beam flatness and penumbra, off-axis ratios at 5 cm depth were measured by film dosimetry using polystyrene phantom. The average error of the mechanical isocenter was 0.27 mm (+/- 0.16 mm). The beam flatness was excellent in the central region of the beam, and the average penumbra width was 3.35 mm (+/- 0.25 mm). The new cone design has more clearance between the patient's head and the gantry, and can more easily be removed from the gantry head because it slides in and out of the wedge slot. This facilitates changing cone sizes during one treatment session, and makes the process of double exposure port films easier. A new collimator cone system for stereotactic radiation therapy has been developed. The mechanical accuracy and physical properties are satisfactory for clinical use, and the new design permits a wider range of clinical applications for stereotactic radiation therapy.
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Kwon, Yu Hyun; Kim, Seul Ki; Cho, Jung Hwan; Kwon, Hyemi; Park, Se Eun; Oh, Hyung Geun; Park, Cheol Young; Lee, Won Young; Oh, Ki Won; Park, Sung Woo; Rhee, Eun Jung
2018-03-01
Hypertriglyceridemia is known to have an association with increased risks of insulin resistance and diabetes. The aim of this study was to investigate the risk of diabetes mellitus, according to changes in the concentrations of triglycerides, over time. A total of 15,932 non-diabetic participants (mean age 43.2 years, 68% men) who attended five consecutive annual health check-ups at Kangbuk Samsung Hospital, between January 2010 and December 2014, were recruited. Participants were classified according to their triglyceride concentrations; normal (<150 mg/dL) and abnormal (≥150 mg/dL). According to the triglyceride levels in 2010 and 2012, subjects were divided into four groups: normal-normal, normal-abnormal, abnormal-normal, and abnormal-abnormal. The risk for incident diabetes was assessed in 2014. Among the total subjects, 67.5% belonged to the normal-normal group, 8.6% to the normal-abnormal group, 9.4% to the abnormal-normal group, and 14.5% to the abnormal-abnormal group. A total of 234 subjects (1.5%) were newly diagnosed with diabetes, between 2010 and 2014. Over 4 years, 1%, 1.5%, 2.1%, and 3.0% of the subjects developed diabetes in the normal-normal, normal-abnormal, abnormal-normal, and abnormal-abnormal groups, respectively. When the risk for incident diabetes was analyzed in the groups, after adjusting the confounding variables, a 1.58-fold increase in the risk of diabetes (95% confidence interval [CI], 1.10 to 2.26) was observed in the participants with persistent hypertriglyceridemia (abnormal-abnormal group). This was attenuated by further adjustments for body mass index (BMI) (hazard ratio, 1.25; 95% CI, 0.86 to 1.80). In this large study population, persistent hypertriglyceridemia, over a period of 2 years, was significantly associated with the risk of incident diabetes, which was attenuated after adjustment for BMI. Copyright © 2018 Korean Endocrine Society.
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Higher superdeformed band members in {sup 190}Hg. Evidence for a band interaction
Energy Technology Data Exchange (ETDEWEB)
Bearden, I G; Daly, P J [Purdue Univ., Lafayette, IN (United States); Janssens, V F; Carpenter, M P; Ahmad, I; Khoo, T L; Lauritsen, T; Liang, Y [Argonne National Lab., IL (United States); Drigert, M W [Idaho National Engineering Lab., Idaho Falls, ID (United States); Garg, U; Reviol, W [Notre Dame Univ., IN (United States); Wyss, R [Joint Inst. for Heavy Ion Research, Oak Ridge, TN (United States)
1992-08-01
The superdeformed band of {sup 190}Hg has been traced up to a frequency {Dirac_h}{omega} {>=} 0.4 MeV by combining data from several experiments. A distinct change in the slope of the dynamic moment of inertia J{sup (2)} vs {Dirac_h}{omega} is observed at {Dirac_h}{omega} 0.32 MeV. This result is interpreted as evidence for a band interaction at the highest frequencies. Possible interpretations are reviewed. (author) 14 refs., 3 figs.
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2011-07-11
... electronic digital media devices and components thereof. The complaint names as respondents Samsung Electronics Co., Ltd. of Korea; Samsung Electronics America Inc. of Ridgefield Park, NJ; and Samsung...
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2012-02-24
.... of TX; Samsung Electronics Co, Ltd. of South Korea; Samsung Electronics America, Inc. of NJ; and Samsung Telecommunications America LLC of TX. Proposed respondents, other interested parties, and members...
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Takefuji, K.; Sugiyama, K.; Yonekura, Y.; Saito, T.; Fujisawa, K.; Kondo, T.
2017-11-01
For the sake of high-sensitivity 6.7 GHz methanol maser observations, we developed a new technology for coherently combining the two signals from the Hitachi 32 m radio telescope and the Takahagi 32 m radio telescope of the Japanese Very long baseline interferometer Network (JVN), where the two telescopes were separated by about 260 m. After the two telescopes were phased as a twofold larger single telescope, the mean signal-to-noise ratio (S/N) of the 6.7 GHz methanol masers observed by the phased telescopes was improved to 1.254-fold higher than that of the single dish, through a very long baseline interferometry (VLBI) experiment on the 50 km baseline of the Kashima 34 m telescope and the 1000 km baseline of the Yamaguchi 32 m telescope. Furthermore, we compared the S/Ns of the 6.7 GHz maser spectra for two methods. One is a VLBI method and the other is the newly developed digital position switching that is a similar technology to that used in noise-canceling headphones. Finally, we confirmed that the mean S/N of method of the digital position switching (ON-OFF) was 1.597-fold higher than that of the VLBI method.
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Superdeformation in the A=150 and A=190 regions
International Nuclear Information System (INIS)
Carpenter, M. P.; Janssens, R. V. F.
1999-01-01
Superdeformation has been established for over a decade in the mass 150 region and nearly as long in the A=190 region. The first measurements directed at nuclei in these regions concentrated on mapping out the superdeformed (SD) islands by identifying SD rotational bands in γ-ray coincidence data. These early studies provided new insights into the physics of superdeformation, but also raised unexpected issues. The new gamma-ray arrays (Gammasphere, Eurogam/Euroball and Gasp) have provided a wealth of new data on properties of SD states in these two mass regions. This paper highlights some of the more recent results from the large arrays which have addressed the outstanding issues in the field, namely, ΔI=4 staggering, identical bands, SD vibrational bands, and questions about the feeding into and the decay out of the SD well. (c) 1999 American Institute of Physics
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2011-08-17
.... 1337, based on a complaint filed by Samsung Electronics Co., Ltd. of Korea (``Samsung'') alleging a... FR 39897 (Jul. 7, 2011). Complainant Samsung named AU Optronics Corp. of Hsinchu, Taiwan; AU...
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Boyko, K. M.; Nikolaeva, A. Yu.; Kachalova, G. S.; Bonchuk, A. N.; Popov, V. O.
2017-11-01
The spatial organization of the genome is controlled by a special class of architectural proteins, including proteins containing BTB domains that are able to dimerize or multimerize. The centrosomal protein 190 is one of such architectural proteins. The purification, crystallization, and preliminary X-ray diffraction study of the BTB domain of the centrosomal protein 190 are reported. The crystallization conditions were found by the vapor-diffusion technique. The crystals diffracted to 1.5 Å resolution and belonged to sp. gr. P3221. The structure was solved by the molecular replacement method. The structure refinement is currently underway.
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Lifetime measurements and dipole transition rates for superdeformed states in {sup 190}Hg.
Energy Technology Data Exchange (ETDEWEB)
Amro, H.
1999-03-24
The Doppler-shift attenuation method was used to measure life-times of superdeformed (SD) states for both the yrast and the first excited superdeformed band of {sup 190}Hg. Intrinsic quadruple moments Q{sub 0} were extracted. For the first time, the dipole transition rates have been extracted for the inter-band transitions which connect the excited SD band to the yrast states in the second minimum. The results support the interpretation of the excited SD band as a rotational band built on an octupole vibration.
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Half-life measurements in doubly-odd sup(186,188,190)Au nuclei and the 188Hg -> Au decay
International Nuclear Information System (INIS)
Abreu, M.C.; Berg, V.; Fransson, K.; Hoeglund, A.; Oms, J.; Porquet, M.G.
1985-01-01
A level scheme has been established for 188 Hg -> Au decay which was studied with the online isotope separator ISOCELE. Precise conversion-electron measurements were performed with a semicircular magnetic spectrograph. The half-lives of the 16.0, 82.7 and 114.8 keV levels in 188 Au were measured with a lens electron spectrometer and reduced transition rates were deduced. Similarly the half-lives of the 36.1, 113.9, 227.7, 251.5, 288.0 and 363.6 keV levels in 186 Au and of the 28.9 and 171.5 keV levels in 190 Au were measured. Comparison of the reduced e.m. transition rates shows that a 1 + and a 2 - state have respectively the same structure in sup(186,) sup(188,) sup(190,) 192 Au, the same conclusion holding for the 1 - sub(g.s.) of sup(188,) sup(190,) 192 Au. Additional measurements in 189 , 191 Hg and 185 , 187 Au together with data from the literature enable us to interpret them as a coupling of certain quasiparticle states of neighbouring odd-A nuclei corresponding to oblate shapes. Indications are given that some other negative- and positive-parity states in 188 Au also belong to an oblate system. The nucleus 188 Au appears as the last of a series of doubly-odd gold nuclei where no shape coexistence has, as yet, been observed. (orig.)
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Directory of Open Access Journals (Sweden)
Sri Wahyuningsih
2014-12-01
Full Text Available This article aims to provide an overview of the cultural wisdom of Madura in advertisement Samsung Galaxy Ivory version by Indonesian celebritis Gading and Giselle in the island of Madura. This study, usin a semiotic analysis of Roland Barthes, tried to unlock the meaning of the signs that are used and re veal the hidden message contained in this advertisement. The author conducted a qualitative study with a research focus on scenes depicting local wisdom of Madurese culture, and then select scenes in advertising that represents local cultural wisdom Madura. Local knowledge of Madurese culture has its own persuasive power. Theme choice by producer of the advertisement is very interesting and has its own character, especially of cattle races, clothing style Madurese, as well as their language and dialect. Madura Island in East Java island region known as the island of salt, and exotic, so well known nationally and internationally. The results of the analysis of mobile phone mentioned found some connotations as follows: (1 the existence of a form of Madurese community thanksgiving in the lens, and (2 cow races, clothing Madura, and language of madurese is indigenous culture of Madura.
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Improvement of strain Penicillium sp. EZ-ZH190 for tannase production by induced mutation.
Zakipour-Molkabadi, E; Hamidi-Esfahani, Z; Sahari, M A; Azizi, M H
2013-11-01
In the search for an efficient producer of tannase, Penicillium sp. EZ-ZH190 was subjected to mutagenesis using heat treatment and strain EZ-ZH290 was isolated. The maximum tannase in this mutant strain was 4.32 U/mL with an incubation period of 84 h as compared to wild strain EZ-ZH190 where the incubation period was 96 h with a maximum enzyme activity of 4.33 U/mL. Also, the Penicillium sp. EZ-ZH290 tannase had a maximum activity at 40 °C and pH 5.5. Then, the spores of strain EZ-ZH290 were subjected to γ irradiation mutagenesis and strain EZ-ZH390 was isolated. Strain EZ-ZH390 exhibited higher tannase activity (7.66 U/mL) than the parent strain EZ-ZH290. It was also found that Penicillium sp. EZ-ZH390 tannase had an optimum activity at 35 °C and a broad pH profile with an optimum at pH 5.5. The tannase pH stability of Penicillium sp. EZ-ZH390 and its maximum production of tannase followed the same trend for five generations confirming the occurrence of stable mutant. This paper is shown that γ irradiation can mutate the Penicillium sp. leading to increase the tannase production.
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AP190L and PDP-KI10: a hardware/software measurement report
International Nuclear Information System (INIS)
Maron, N.; Sutherland, G.G.
1979-01-01
This report discusses an AP190L array processor (manufactured by Floating Point Systems of Beaverton, Oregon) interfaced to a PDP-10 (Digital Equipment Corporation, Maynard, Mass.). After AP software installation, an analysis of the overhead was performed. The results of these measurements and some conclusions are presented. An AP monitor and software interface were written to minimize the overhead from the PDP-10. A vector extension to the FORTRAN language called FIVE was developed to increase user access to the AP. Some of the problems associated with defining and implementing FIVE are discussed. Its successes and limitations are reviewed. 2 figures, 2 tables
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Directory of Open Access Journals (Sweden)
Hirofumi Ota
2012-01-01
Full Text Available Much research has been carried out on the accumulation and effective use of knowledge as a company-specific form of intellectual property. However, insufficient attention has been given to research focusing on the effects of micro-level knowledge absorption and its effective use. In this paper, we try to demonstrate what should be done in order to promote new biotech business from the perspective of each engineer’s knowledge, through a micro-level investigation focusing on the life science business section of one IT enterprise. Based on the results of a questionnaire survey of engineers, interviews of several engineers, and patent data analysis, we discuss the progress of the biotech business in an IT enterprise from the aspect of accumulation and circulation of knowledge in a core technology field, the IT business, and a technology field of new entry, the biotech business. This paper reports that the positive growth cycle of biotech business promotion in an IT enterprise, using Hitachi Software Engineering Co., Ltd. as a case, attained by incorporating the latest biotech knowledge from junior engineers and utilizing IT knowledge from middle engineers leads to the recruiting of qualified students.Keywords: accumulation and circulation of the knowledge, biotech business, open innovation, patent data analysis, questionnaire survey
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2010-04-01
... § 1.190-2(b) of this chapter). In the case of a partnership, the election shall be made by the partnership. The election applies to expenditures paid or incurred during the taxable year which (but for the election) are chargeable to capital account. (b) Limitation. The maximum deduction for a taxpayer...
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2011-12-20
... granted to Mitsubishi, Fujitsu General Ltd. (Fujitsu), Samsung Air Conditioning (Samsung), Daikin, Sanyo... characteristics similar to the commercial multi-split products manufactured by Mitsubishi, as well as by Samsung... V III VRF multi-split equipment, for compliance, marketing, or other purposes, LG must fairly...
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2010-02-19
... the Tariff Act of 1930, as amended, 19 U.S.C. Sec. 1337, based on a complaint filed by Samsung Electronics Co., Ltd. of Korea and Samsung Electronics America, Inc. of Ridgefield Park, New Jersey (collectively, ``Samsung'') on February 17, 2009, and supplemented [[Page 7520
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International Nuclear Information System (INIS)
Cizeron-Clairac, Geraldine; Lallemand, François; Vacher, Sophie; Lidereau, Rosette; Bieche, Ivan; Callens, Celine
2015-01-01
MicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles. Numerous microarray studies reported different expression patterns of miRNAs in breast cancers and found clinical interest for several miRNAs but often with contradictory results. Aim of this study is to identify miRNAs that are differentially expressed in estrogen receptor positive (ER + ) and negative (ER − ) breast primary tumors to better understand the molecular basis for the phenotypic differences between these two sub-types of carcinomas and to find potential clinically relevant miRNAs. We used the robust and reproductive tool of quantitative RT-PCR in a large cohort of well-annotated 153 breast cancers with long-term follow-up to identify miRNAs specifically differentially expressed between ER + and ER − breast cancers. Cytotoxicity tests and transfection experiments were then used to examine the role and the regulation mechanisms of selected miRNAs. We identified a robust collection of 20 miRNAs significantly deregulated in ER + compared to ER − breast cancers : 12 up-regulated and eight down-regulated miRNAs. MiR-190b retained our attention as it was the miRNA the most strongly over-expressed in ER + compared to ER − with a fold change upper to 23. It was also significantly up-regulated in ER + /Normal breast tissue and down-regulated in ER − /Normal breast tissue. Functional experiments showed that miR-190b expression is not directly regulated by estradiol and that miR-190b does not affect breast cancer cell lines proliferation. Expression level of miR-190b impacts metastasis-free and event-free survival independently of ER status. This study reveals miR-190b as the highest up-regulated miRNA in hormone-dependent breast cancers. Due to its specificity and high expression level, miR-190b could therefore represent a new biomarker in hormone-dependent breast cancers but its exact role carcinogenesis remains to
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Gye, Hyo Jung; Kim, Joon Mo; Yoo, Chungkwon; Shim, Seong Hee; Won, Yu Sam; Sung, Ki Chul; Lee, Mi Yeon; Park, Ki Ho
2016-12-01
To investigate the association between serum ferritin levels and glaucoma in a South Korean population. This retrospective cross-sectional study included 164 029 subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. All subjects underwent a physical examination, answered sociodemographic and behavioural questions, and provided samples for laboratory analyses. A digital fundus photograph of both eyes was taken, and all photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye had glaucoma based on criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and the appearance of the retinal nerve fibre layer and optic disc. The mean serum ferritin level was 56.98 ng/mL in women and 223.82 ng/mL in men. After adjusting for age, serum iron, total iron-binding capacity (TIBC), transferrin saturation, white blood cell (WBC) count, high-sensitivity C-reactive protein (HsCRP) and total vitamin D level, males in the highest quartile for serum ferritin level had a higher OR for glaucoma than males in the lowest quartile (OR=1.176, 95% CI 1.030 to 1.342, p=0.016); we did not observe this relationship among women. Other markers of iron metabolism, such as iron level, transferrin saturation and TIBC, and inflammation measures, including WBC, HsCRP and total vitamin D, were not associated with glaucoma. High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
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AVC/H.264 patent portfolio license
Skandalis, Dean A.
2006-08-01
MPEG LA, LLC offers a joint patent license for the AVC (a/k/a H.264) Standard (ISO/IEC IS 14496-10:2004). Like MPEG LA's other licenses, the AVC Patent Portfolio License is offered for the convenience of the marketplace as an alternative enabling users to access essential intellectual property owned by many patent holders under a single license rather than negotiating licenses with each of them individually. The AVC Patent Portfolio License includes essential patents owned by DAEWOO Electronics Corporation; Electronics and Telecommunications Research Institute (ETRI); France Telecom, societe anonyme; Fujitsu Limited; Hitachi, Ltd.; Koninklijke Philips Electronics N.V.; LG Electronics Inc.; Matsushita Electric Industrial Co., Ltd.; Microsoft Corporation; Mitsubishi Electric Corporation; Robert Bosch GmbH; Samsung Electronics Co., Ltd.; Sedna Patent Services, LLC; Sharp Kabushiki Kaisha; Siemens AG; Sony Corporation; The Trustees of Columbia University in the City of New York; Toshiba Corporation; UB Video Inc.; and Victor Company of Japan, Limited. Another is expected also to join as of August 1, 2006. MPEG LA's objective is to provide worldwide access to as much AVC essential intellectual property as possible for the benefit of AVC users. Therefore, any party that believes it has essential patents is welcome to submit them for evaluation of their essentiality and inclusion in the License if found essential.
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Staggering in signature partners of A∼190 mass region of superdeformed rotational bands
International Nuclear Information System (INIS)
Uma, V.S.; Goel, Alpana; Yadav, Archana
2014-01-01
This paper discuss about ΔI=1 signature splitting in signature partner pairs of A∼190 mass region. Around twenty signature partner pairs (usually called as two bands, each with a fixed signature) have been reported in this mass region. For these signature pairs, band head moment of inertia (J 0 ) and intrinsic structure of each pair of signature partners have been found as almost identical. Also, these signature partner pairs showed large amplitude signature splitting. As each of the two signature partner forms a regular spin sequence and signature bands are not equivalent in terms of energies. This difference in energies results in signature splitting
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International Nuclear Information System (INIS)
Lin, Pei-Jan P.; Schueler, Beth A.; Balter, Stephen; Strauss, Keith J.; Wunderle, Kevin A.; LaFrance, M. Terry; Kim, Don-Soo; Behrman, Richard H.; Shepard, S. Jeff; Bercha, Ishtiaq H.
2015-01-01
Due to the proliferation of disciplines employing fluoroscopy as their primary imaging tool and the prolonged extensive use of fluoroscopy in interventional and cardiovascular angiography procedures, “dose-area-product” (DAP) meters were installed to monitor and record the radiation dose delivered to patients. In some cases, the radiation dose or the output value is calculated, rather than measured, using the pertinent radiological parameters and geometrical information. The AAPM Task Group 190 (TG-190) was established to evaluate the accuracy of the DAP meter in 2008. Since then, the term “DAP-meter” has been revised to air kerma-area product (KAP) meter. The charge of TG 190 (Accuracy and Calibration of Integrated Radiation Output Indicators in Diagnostic Radiology) has also been realigned to investigate the “Accuracy and Calibration of Integrated Radiation Output Indicators” which is reflected in the title of the task group, to include situations where the KAP may be acquired with or without the presence of a physical “meter.” To accomplish this goal, validation test protocols were developed to compare the displayed radiation output value to an external measurement. These test protocols were applied to a number of clinical systems to collect information on the accuracy of dose display values in the field
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Energy Technology Data Exchange (ETDEWEB)
Lin, Pei-Jan P., E-mail: Pei-Jan.Lin@vcuhealth.org [Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 (United States); Schueler, Beth A. [Mayo Clinic, Rochester, Minnesota 55905 (United States); Balter, Stephen [Columbia University Medical Center, New York, New York 10032 (United States); Strauss, Keith J. [Children’s Hospital Medical Center, Cincinnati, Ohio 45229 (United States); Wunderle, Kevin A. [Cleveland Clinic Foundation, Cleveland, Ohio 44195 (United States); LaFrance, M. Terry [Baystate Health Systems, Inc., Springfield, Massachusetts 01199 (United States); Kim, Don-Soo [Children’s Hospital Boston, Boston, Massachusetts 02115 (United States); Behrman, Richard H. [Boston University Medical Center, Boston, Massachusetts 02118 (United States); Shepard, S. Jeff [University of Texas MD Anderson Cancer Center, Houston, Texas 77096 (United States); Bercha, Ishtiaq H. [Children’s Hospital Colorado, Aurora, Colorado 80045 (United States)
2015-12-15
Due to the proliferation of disciplines employing fluoroscopy as their primary imaging tool and the prolonged extensive use of fluoroscopy in interventional and cardiovascular angiography procedures, “dose-area-product” (DAP) meters were installed to monitor and record the radiation dose delivered to patients. In some cases, the radiation dose or the output value is calculated, rather than measured, using the pertinent radiological parameters and geometrical information. The AAPM Task Group 190 (TG-190) was established to evaluate the accuracy of the DAP meter in 2008. Since then, the term “DAP-meter” has been revised to air kerma-area product (KAP) meter. The charge of TG 190 (Accuracy and Calibration of Integrated Radiation Output Indicators in Diagnostic Radiology) has also been realigned to investigate the “Accuracy and Calibration of Integrated Radiation Output Indicators” which is reflected in the title of the task group, to include situations where the KAP may be acquired with or without the presence of a physical “meter.” To accomplish this goal, validation test protocols were developed to compare the displayed radiation output value to an external measurement. These test protocols were applied to a number of clinical systems to collect information on the accuracy of dose display values in the field.
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Lafi, Feras Fawzi; Alam, Intikhab; Geurts, Rene; Bisseling, Ton; Bajic, Vladimir B.; Hirt, Heribert; Saad, Maged
2016-01-01
Pseudomonas argentinensis strain SA190 is a plant endophytic-inhabiting bacterium that was isolated from root nodules of the desert plant Indigofera argentea collected from the Jizan region of Saudi Arabia. Here, we report the genome sequence of SA
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MRI-detection rate and incidence of lumbar bleeding sources in 190 patients with non-aneurysmal SAH.
Directory of Open Access Journals (Sweden)
Sepide Kashefiolasl
Full Text Available Up to 15% of all spontaneous subarachnoid hemorrhages (SAH have a non-aneurysmal SAH (NASAH. The evaluation of SAH patients with negative digital subtraction angiography (DSA is sometimes a diagnostic challenge. Our goal in this study was to reassess the yield of standard MR-imaging of the complete spinal axis to rule out spinal bleeding sources in patients with NASAH.We retrospectively analyzed the spinal MRI findings in 190 patients with spontaneous NASAH, containing perimesencephalic (PM and non-perimesencephalic (NPM SAH, diagnosed by computer tomography (CT and/or lumbar puncture (LP, and negative 2nd DSA.190 NASAH patients were included in the study, divided into PM-SAH (n = 87; 46% and NPM-SAH (n = 103; 54%. Overall, 23 (22% patients had a CT negative SAH, diagnosed by positive LP. MR-imaging of the spinal axis detected two patients with lumbar ependymoma (n = 2; 1,05%. Both patients complained of radicular sciatic pain. The detection rate raised up to 25%, if only patients with radicular sciatic pain received an MRI.Routine radiological investigation of the complete spinal axis in NASAH patients is expensive and can not be recommended for standard procedure. However, patients with clinical signs of low-back/sciatic pain should be worked up for a spinal pathology.
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Directory of Open Access Journals (Sweden)
Luz M Morera Barrios
2002-12-01
Full Text Available Se estudió la histocompatibilidad de los loci ABC y del locus D del sistema principal de histocompatibilidad mediante las técnicas serológicas de microlinfocitotoxicidad en 383 pacientes con diferentes enfermedades hematológicas. Se comparó por la técnica celular y la reactividad linfocitaria en el cultivo mixto de linfocitos (CML de 39 de los 145 individuos idénticos para los antígenos HLA, de los estudios familiares realizados en el IHI, de los que resultaron 29 CML negativos, para el 74,35 %. No se correspondieron en el 100 % los estudios serológicos y celulares, ya que no se compatibilizó en todos los casos para los antígenos HLA de clase II, y en ninguno para los antígenos menores de histocompatibilidad, que influyen tanto en los resultados del CML, como en las causas de fracaso del trasplante de médula ósea (TMO en individuos idénticos. Esto corrobora la importancia de los estudios de tipificación de Biología Molecular y antígenos menores de histocompatibilidadThe histocompatibility of loci ABC and locus D of the main histocompatibility system was studied by serological techniques of microlymphocytotoxicity in 383 patients with various hematological diseases. Lymphocyte reactivity was compared in the mixed lymphocyte culture of 39 of 145 identical individuals for HLA antigens, of whom 29 were negative MLC for 74,35%. There was not 100% correspondence between serological and cellular studies since there was no compatibility in all the cases for HLA class II antigens and in any case for minor histocompatibility antigens that influence both the results of MLC and the causes of failed bone marrow transplantation in identical individuals. This confirms the importance of Molecular Biology typing studies and of minor histocompatibility antigens
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2011-08-18
... 337 of the Tariff Act of 1930, as amended, 19 U.S.C. 1337, on behalf of Samsung LED Co., Ltd. of Korea and Samsung LED America, Inc. of Atlanta, Georgia. The complaint alleges violations of section 337... shall be served: (a) The complainants are: Samsung LED Co., Ltd., 314, Maetan 3-Dong, Yeongtong-gu...
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Directory of Open Access Journals (Sweden)
Camila S. Hamú
2007-12-01
Full Text Available A leucemia mielóide crônica (LMC é uma doença proliferativa do sistema hematopoiético, caracterizada pela expansão clonal de uma célula-tronco primitiva e pluripotente denominada stem cell. Este tipo de leucemia está associado, em 90% dos casos, à translocação t(9;22(q34;q11. Essa alteração cromossômica estrutural codifica para uma proteína quimérica BCR-ABL, que confere às células leucêmicas uma alta resistência à morte, independente do agente indutor desse processo. A proteína p53 é uma reguladora transcricional induzida por danos no DNA, fato que resulta na parada do ciclo celular com conseqüente ativação de mecanismos de reparo ou mesmo na indução à apoptose. As mutações no gene TP53 são as alterações genéticas mais comuns em tumores malignos humanos. O presente estudo teve como objetivo genotipar e determinar a freqüência alélica do polimorfismo do TP53 no códon 72 (arginina - Arg e prolina - Pro, em pacientes com suspeita de LMC, pela Reação em Cadeia da Polimerase. Desta forma, os resultados indicaram que 73,4% (23/30 dos pacientes apresentaram homozigose para arginina (Arg/Arg e 26,6% (7/30 heterozigose (Arg/Pro. Não foi encontrado nenhum paciente homozigoto para prolina (Pro/Pro. Os resultados obtidos sugerem que o polimorfismo do gene TP53 no códon 72 não é um fator de risco importante para a iniciação, promoção e progressão da LMC.Chronic myeloid leukemia (CML is a proliferative disorder of the hematopoietic system characterized by clonal expansion of a primitive and pluripotent stem cell. In this type of leukemia, up to 90% of all cases is associated to a specific chromosomal translocation, t(9;22(q34;q11. The genomic alteration results in a chimeric protein, BCR-ABL, that confers a high resistance leukemia cells to death, independent of the induction mechanism of this process. Protein p53 is a transcriptional factor expressed after DNA damage which ceases cell cycle progression and
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2011-08-22
... section 337 of the Tariff Act of 1930, as amended, 19 U.S.C. 1337, on behalf of Samsung LED Co., Ltd. of Korea and Samsung LED America, Inc. of Atlanta, Georgia. The complaint alleges violations of section 337... shall be served: (a) The complainants are: Samsung LED Co., Ltd., 314, Maetan 3-Dong, Yeongtong-gu...
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Investigations of fast neutron production by 190 GeV/c muon interactions on graphite target
Chazal, V; Cook, B; Henrikson, H; Jonkmans, G; Paic, A; Mascarenhas, N; Vogel, P; Vuilleumier, J L
2002-01-01
The production of fast neutrons (1 MeV - 1 GeV) in high energy muon-nucleus interactions is poorly understood, yet it is fundamental to the understanding of the background in many underground experiments. The aim of the present experiment (CERN NA55) was to measure spallation neutrons produced by 190 GeV/c muons scattering on carbon target. We have investigated the energy spectrum and angular distribution of spallation neutrons, and we report the result of our measurement of the neutron production differential cross section.
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International Nuclear Information System (INIS)
Wickline, Alfred
2006-01-01
Corrective Action Unit (CAU) 190 is located in Areas 11 and 14 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 190 is comprised of the four Corrective Action Sites (CASs) listed below: (1) 11-02-01, Underground Centrifuge; (2) 11-02-02, Drain Lines and Outfall; (3) 11-59-01, Tweezer Facility Septic System; and (4) 14-23-01, LTU-6 Test Area. These sites are being investigated because existing information is insufficient on the nature and extent of potential contamination to evaluate and recommend corrective action alternatives. Additional information will be obtained before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS by conducting a corrective action investigation (CAI). The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on August 24, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture, and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 190. The scope of the CAU 190 CAI includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling; (2) Conduct radiological and geophysical surveys; (3) Perform field screening; (4) Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern (COCs) are present; (5) If COCs are present, collect additional step-out samples to define the lateral and vertical extent of the contamination; (6) Collect samples of source material, if present
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International Nuclear Information System (INIS)
Adebayo, Matthew A.; Prola, Lizie D.T.; Lima, Eder C.; Puchana-Rosero, M.J.; Cataluña, Renato; Saucier, Caroline; Umpierres, Cibele S.; Vaghetti, Julio C.P.; Silva, Leandro G. da; Ruggiero, Reinaldo
2014-01-01
Graphical abstract: - Highlights: • Complexes of carboxy-methylated lignin with Al and Mn were used as adsorbents. • The optimum adsorption conditions were achieved at pH 2 and 298 K. • Maximum adsorption capacities are 73.52 mg g −1 (CML-Al) and 55.16 mg g −1 (CML-Mn). • CML-Al could remove ca. 95.83% of dye-contaminated industrial effluents. • CML-Al and CML-Mn are effective for treatment of simulated dye-house effluents. - Abstract: A macromolecule, CML, was obtained by purifying and carboxy-methylating the lignin generated from acid hydrolysis of sugarcane bagasse during bioethanol production from biomass. The CMLs complexed with Al 3+ (CML-Al) and Mn 2+ (CML-Mn) were utilised for the removal of a textile dye, Procion Blue MX-R (PB), from aqueous solutions. CML-Al and CML-Mn were characterised using Fourier transform infrared spectroscopy (FTIR), scanning differential calorimetry (SDC), scanning electron microscopy (SEM) and pH PZC . The established optimum pH and contact time were 2.0 and 5 h, respectively. The kinetic and equilibrium data fit into the general order kinetic model and Liu isotherm model, respectively. The CML-Al and CML-Mn have respective values of maximum adsorption capacities of 73.52 and 55.16 mg g −1 at 298 K. Four cycles of adsorption/desorption experiments were performed attaining regenerations of up to 98.33% (CML-Al) and 98.08% (CML-Mn) from dye-loaded adsorbents, using 50% acetone + 50% of 0.05 mol L −1 NaOH. The CML-Al removed ca. 93.97% while CML-Mn removed ca. 75.91% of simulated dye house effluents
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Directory of Open Access Journals (Sweden)
K. Nishio
2015-09-01
Full Text Available Mass distributions of fission fragments from the compound nuclei 180Hg and 190Hg formed in fusion reactions 36Ar + 144Sm and 36Ar + 154Sm, respectively, were measured at initial excitation energies of E⁎(Hg180=33–66 MeV and E⁎(Hg190=48–71 MeV. In the fission of 180Hg, the mass spectra were well reproduced by assuming only an asymmetric-mass division, with most probable light and heavy fragment masses A¯L/A¯H=79/101. The mass asymmetry for 180Hg agrees well with that obtained in the low-energy β+/EC-delayed fission of 180Tl, from our earlier ISOLDE(CERN experiment. Fission of 190Hg is found to proceed in a similar way, delivering the mass asymmetry of A¯L/A¯H=83/107, throughout the measured excitation energy range. The persistence as a function of excitation energy of the mass-asymmetric fission for both proton-rich Hg isotopes gives strong evidence for the survival of microscopic effects up to effective excitation energies of compound nuclei as high as 40 MeV. This behavior is different from fission of actinide nuclei and heavier mercury isotope 198Hg.
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DEFF Research Database (Denmark)
Järås, Marcus; Johnels, Petra; Agerstam, Helena
2009-01-01
OBJECTIVE: The P190 and P210 BCR/ABL1 fusion genes are mainly associated with different types of hematologic malignancies, but it is presently unclear whether they are functionally different following expression in primitive human hematopoietic cells. MATERIALS AND METHODS: We investigated...... and systematically compared the effects of retroviral P190 BCR/ABL1 and P210 BCR/ABL1 expression on cell proliferation, differentiation, and global gene expression in human CD34(+) cells from cord blood. RESULTS: Expression of either P190 BCR/ABL1 or P210 BCR/ABL1 resulted in expansion of erythroid cells...... and stimulated erythropoietin-independent burst-forming unit-erythroid colony formation. By using a lentiviral anti-signal transducer and activator of transcription 5 (STAT5) short-hairpin RNA, we found that both P190 BCR/ABL1- and P210 BCR/ABL1-induced erythroid cell expansion were STAT5-dependent. Under...
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Gamma-ray deexcitation of 0/sup +/, 2/sup +/ states in /sup 188/ /sup 190/Os
Energy Technology Data Exchange (ETDEWEB)
Macphail, M R; Casten, R F; Kane, W R [Brookhaven National Lab., Upton, N.Y. (USA)
1975-12-08
The ..gamma..-ray deexcitation of eight 0/sup +/ states in /sup 188/ /sup 190/Os was studied with the (n,..gamma..) reaction. For all eight 0/sup +/ states the depopulation was primarily to the 2/sup +//sub ..gamma../ rather than to the 2/sup +//sub g/ level. The 2/sup +/ level above the lowest excited 0/sup +/ state in each nucleus was found to decay predominantly to the excited 0/sup +/ level. Comparisons of these results to the longitudinal correspondence model and to the calculations of Kumar and Barranger are made.
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Investigations of fast neutron production by 190 GeV/c muon interactions on different targets
International Nuclear Information System (INIS)
Chazal, V.; Boehm, F.; Cook, B.; Henrikson, H.; Jonkmans, G.; Paic, A.; Mascarenhas, N.; Vogel, P.; Vuilleumier, J.-L.
2002-01-01
The production of fast neutrons (1 MeV-1 GeV) in high-energy muon-nucleus interactions is poorly understood, yet it is fundamental to the understanding of the background in many underground experiments. The aim of the present experiment (CERN NA55) was to measure spallation neutrons produced by 190 GeV/c muons scattering on carbon, copper and lead targets. We have investigated the energy spectrum and angular distribution of spallation neutrons, and we report the result of our measurement of the neutron production differential cross-section
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International Nuclear Information System (INIS)
Marske, S.G.
1996-07-01
This sampling and analysis plan describes the sample collection and sample analysis in support of the 105-C water tunnels and 190-C main pumphouse concrete and soil sampling activities. These analytical data will be used to identify the radiological contamination and presence of hazardous materials to support the decontamination and disposal activities
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Yu, L; Wang, H B; Huang, X J; Jiang, Q
2016-07-01
To explore the impact of Glivec related side effects on daily life in Chinese patients with chronic myeloid leukemia (CML) in the chronic phase (CP). From May to November in 2014, anonymous questionnaires were distributed to adult CML patients who were receiving tyrosine kinase inhibitors (TKI) treatment in China. The impact of TKI related side effects on daily life were assessed by the score of 1 (no impact) to 5 (high impact) from patient self- report. Data from 548 respondents in the CP on Glivec were collected. 303(55%) cases were male with the median age of 40 years (range, 18 to 88 years). 437 (80% ) cases started Glivec treatment within one year after diagnosis with a median treatment duration of 3 years (range, effects were edema (n=278, 51% ), fatigue (n=218, 40% ), gastrointestinal disorders (n=190, 35%), muscle cramps (n=118, 22%), skin color changes (n=118, 22%), weight gain (n=71, 13%), rash (n=60, 11%), hepatic function abnormality (n=55, 10%), and cytopenia (n=38, 7%). Among the 548 respondents, the mean score of Glivec-related side effects on daily life was 2.4±1.2. There was no negative impact of Glivec related side effects on daily life in 161(29%) respondents. 295 (54% ) and 92 (17% ) respondents reported slightly or moderately (2- 3 score) and significantly decreased (4-5 score) daily life, respectively. Multivariate analysis showed that Glivec treatment duration effects including fatigue (OR=2.9, 95% CI 2.1-4.1;Pnegative effect on daily life. Daily life was impaired seriously in a minority of Chinese CML patients who received Glivec, especially in the first 4 years of treatment. Fatigue, edema, gastrointestinal disorders, rash and hepatic function abnormality were side effects associated with negative impact on patients' daily life.
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1990 Annual Tropical Cyclone Report
1995-01-01
land) - followed further loss of convective organization as system underwent increased vertical wind shear and loss of latent and sensible heat. III...FOLXTECHNICOF HONG KONG CIUDAD UNIVERSITARLA,M)XICO CML DEFENSE, BELAU CML DEFENSE, MAJURO CML DEFENSE, POHNPEI CML DEFENSE, SAIPAN CML DEFENSE, TRUK
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International Nuclear Information System (INIS)
Duprat, J.
1995-01-01
This work concerns the study of the nuclear superdeformation phenomenon in the A = 190 mass region. The superdeformed (SD) states in 193 Tl, 194 Tl 195 Tl were produced via heavy-ion induced reactions and studied with the EUROGAM gamma multidetector array. The analysis of high-multiplicity events allowed the study of the magnetic properties of the SD states in these nuclei. For the first time, the g-factor of a proton orbital in a SD nucleus in the A = 190 mass region has been extracted. This measurement indicates that the two known bands in 195 Tl-SD are built on the i 13/2 proton intruder orbital. A new SD band has been found in this isotope: it is the first SD band built on an excited proton state found in the A = 190 region. Finally an interaction between two pairs of bands has been established in 194 Tl; this interaction indicate the crossing of two neutron orbitals above the N = 112 gap. The magnetic properties of the states of the SD bands in 194 Tl reveals that these bands are built on configurations in which the single proton and neutron intrinsic spins are aligned. Comparison between different SD bands in the Thallium isotopes shows the prominent role of the i 13/2 proton and the j 15/2 neutron intruder orbitals in the smooth increase of the dynamical moment of inertia as a function of the rotational frequency. In addition, this work reports on the first observation of a SD rotational band produced in a (HI, αxn) reaction channel. The study of the maximum spin reached by the SD bands indicates both a competition between alpha emission and fission of the compound nucleus, and the limitation due to the fission process in the population of the SD nuclei in the A = 190 region. (author). 120 refs., 112 figs., 22 tabs., 2 ann
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Effect of structural defects on the magnetic properties of the EuBaCo1.90O5.36 single crystal
Arbuzova, T. I.; Naumov, S. V.; Telegin, S. V.
2018-01-01
The effect of structural defects in cobalt and oxygen sublattices with the constant average oxidation level 3+ of all cobalt ions on the magnetic properties of the EuBaCo1.90O5.36 single crystal has been studied. The magnetic properties of the single crystal and the polycrystalline sample of the corresponding composition are compared in the range T = 200-650 K. The results show that the cobalt-deficient EuBaCo2- x O5.5-δ samples demonstrate a three-dimensional XY ferromagnetic ordering of magnetic sublattices. The values of the effective magnetic moment at T > 480 K indicate the existence of the IS and HS states of Co3+ ions. The large difference of values of μeff of the EuBaCo1.90O5.36 single crystal and polycrystal can be due to that the magnetic ion spins lie in plane ab. The magnetic field directed along plane ab substantially influences the magnetic ordering at T < 300 K.
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Directory of Open Access Journals (Sweden)
Ryosuke Shirasaki
2012-01-01
Full Text Available We recently reported that chronic myelogenous leukemia (CML cells converted into myofibroblasts to create a microenvironment for proliferation of CML cells in vitro. To analyze a biological contribution of CML-derived myofibroblasts in vivo, we observed the characters of leukemic nonobese diabetes/severe combined immunodeficiency (NOD/SCID mouse. Bone marrow nonadherent mononuclear cells as well as human CD45-positive cells obtained from CML patients were injected to the irradiated NOD/SCID mice. When the chimeric BCR-ABL transcript was demonstrated in blood, human CML cells were detected in NOD/SCID murine bone marrow. And CML-derived myofibroblasts composed with the bone marrow-stroma, which produced significant amounts of human vascular endothelial growth factor A. When the parental CML cells were cultured with myofibroblasts separated from CML cell-engrafted NOD/SCID murine bone marrow, CML cells proliferated significantly. These observations indicate that CML cells make an adequate microenvironment for their own proliferation in vivo.
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Energy Technology Data Exchange (ETDEWEB)
Adebayo, Matthew A. [Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500, Postal Box 15003, 91501-970 Porto Alegre, RS (Brazil); Department of Chemical Sciences, Ajayi Crowther University, PMB 1066 Oyo, Oyo State (Nigeria); Prola, Lizie D.T. [Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500, Postal Box 15003, 91501-970 Porto Alegre, RS (Brazil); Lima, Eder C., E-mail: eder.lima@ufrgs.br [Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500, Postal Box 15003, 91501-970 Porto Alegre, RS (Brazil); Puchana-Rosero, M.J.; Cataluña, Renato; Saucier, Caroline; Umpierres, Cibele S.; Vaghetti, Julio C.P. [Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500, Postal Box 15003, 91501-970 Porto Alegre, RS (Brazil); Silva, Leandro G. da; Ruggiero, Reinaldo [Institute of Chemistry, Federal University of Uberlândia (UFU), AV. João Naves de Ávila 2121 block 1D—Campus Santa Mônica, 38400-902 Uberlândia, MG (Brazil)
2014-03-01
Graphical abstract: - Highlights: • Complexes of carboxy-methylated lignin with Al and Mn were used as adsorbents. • The optimum adsorption conditions were achieved at pH 2 and 298 K. • Maximum adsorption capacities are 73.52 mg g{sup −1} (CML-Al) and 55.16 mg g{sup −1} (CML-Mn). • CML-Al could remove ca. 95.83% of dye-contaminated industrial effluents. • CML-Al and CML-Mn are effective for treatment of simulated dye-house effluents. - Abstract: A macromolecule, CML, was obtained by purifying and carboxy-methylating the lignin generated from acid hydrolysis of sugarcane bagasse during bioethanol production from biomass. The CMLs complexed with Al{sup 3+} (CML-Al) and Mn{sup 2+} (CML-Mn) were utilised for the removal of a textile dye, Procion Blue MX-R (PB), from aqueous solutions. CML-Al and CML-Mn were characterised using Fourier transform infrared spectroscopy (FTIR), scanning differential calorimetry (SDC), scanning electron microscopy (SEM) and pH{sub PZC}. The established optimum pH and contact time were 2.0 and 5 h, respectively. The kinetic and equilibrium data fit into the general order kinetic model and Liu isotherm model, respectively. The CML-Al and CML-Mn have respective values of maximum adsorption capacities of 73.52 and 55.16 mg g{sup −1} at 298 K. Four cycles of adsorption/desorption experiments were performed attaining regenerations of up to 98.33% (CML-Al) and 98.08% (CML-Mn) from dye-loaded adsorbents, using 50% acetone + 50% of 0.05 mol L{sup −1} NaOH. The CML-Al removed ca. 93.97% while CML-Mn removed ca. 75.91% of simulated dye house effluents.
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HITACHI construction CAE system
International Nuclear Information System (INIS)
Yoshida, M.
1994-01-01
Construction and maintenance of nuclear power plants have important problems such as shortening the construction period and reducing the construction cost. Recently, the problem of insufficient construction labor has arisen, and as drastic strategic development has become a necessary counter-measure. The following four principles are included in the measures to be taken for efficient execution of the construction work within the short construction period: (1) reduction of on-site work and expansion of module block making, (2)improvement of the accuracy of the on-site work process, adjustment and expansion of the work in parallel with the construction process, (3)improvement of efficiency of the on-site work and mechanization and automation of the work, (4)improvement of the accuracy of the management of the construction. A three dimensional simulation system plant construction plan CAE, comprising five modules has been developed. A project management system was also developed to improve the accuracy and efficiency of management work in the field
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Production and chemical characterization of pigments in filamentous fungi.
Souza, Patrícia Nirlane da Costa; Grigoletto, Tahuana Luiza Bim; de Moraes, Luiz Alberto Beraldo; Abreu, Lucas M; Guimarães, Luís Henrique Souza; Santos, Cledir; Galvão, Luciano Ribeiro; Cardoso, Patrícia Gomes
2016-01-01
Production of pigments by filamentous fungi is gaining interest owing to their use as food colourants, in cosmetics and textiles, and because of the important biological activities of these compounds. In this context, the objectives of this study were to select pigment-producing fungi, identify these fungi based on internal transcribed spacer sequences, evaluate the growth and pigment production of the selected strains on four different media, and characterize the major coloured metabolites in their extracts. Of the selected fungal strains, eight were identified as Aspergillus sydowii (CML2967), Aspergillus aureolatus (CML2964), Aspergillus keveii (CML2968), Penicillium flavigenum (CML2965), Penicillium chermesinum (CML2966), Epicoccum nigrum (CML2971), Lecanicillium aphanocladii (CML2970) and Fusarium sp. (CML2969). Fungal pigment production was influenced by medium composition. Complex media, such as potato dextrose and malt extract, favoured increased pigment production. The coloured compounds oosporein, orevactaene and dihydrotrichodimerol were identified in extracts of L. aphanocladii (CML2970), E. nigrum (CML2971), and P. flavigenum (CML2965), respectively. These results indicate that the selected fungal strains can serve as novel sources of pigments that have important industrial applications.
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Energy Technology Data Exchange (ETDEWEB)
Duprat, J
1995-01-01
This work concerns the study of the nuclear superdeformation phenomenon in the A = 190 mass region. The superdeformed (SD) states in {sup 193}Tl, {sup 194}Tl {sup 195}Tl were produced via heavy-ion induced reactions and studied with the EUROGAM gamma multidetector array. The analysis of high-multiplicity events allowed the study of the magnetic properties of the SD states in these nuclei. For the first time, the g-factor of a proton orbital in a SD nucleus in the A = 190 mass region has been extracted. This measurement indicates that the two known bands in {sup 195}Tl-SD are built on the i{sub 13/2} proton intruder orbital. A new SD band has been found in this isotope: it is the first SD band built on an excited proton state found in the A = 190 region. Finally an interaction between two pairs of bands has been established in {sup 194}Tl; this interaction indicate the crossing of two neutron orbitals above the N = 112 gap. The magnetic properties of the states of the SD bands in {sup 194}Tl reveals that these bands are built on configurations in which the single proton and neutron intrinsic spins are aligned. Comparison between different SD bands in the Thallium isotopes shows the prominent role of the i{sub 13/2} proton and the j{sub 15/2} neutron intruder orbitals in the smooth increase of the dynamical moment of inertia as a function of the rotational frequency. In addition, this work reports on the first observation of a SD rotational band produced in a (HI, {alpha}xn) reaction channel. The study of the maximum spin reached by the SD bands indicates both a competition between alpha emission and fission of the compound nucleus, and the limitation due to the fission process in the population of the SD nuclei in the A = 190 region. (author). 120 refs., 112 figs., 22 tabs., 2 ann.
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International Nuclear Information System (INIS)
Babaev, B.N.; Dalimov, D.N.; Gafurova, R.N.; Kadyrova, D.M.; Abdullaeva, L.K.; Abdurakhmanova, U.K.; Ganiev, A.G.; Rakhimov, Kh.R.
1997-01-01
The method of labelled atoms(silver 110 and gold 190) was used for study of extraction properties of different derivatives of thiophosphoric acids. The study have shown that the extraction effectiveness depends both on matter structure and on ph value of medium and type of acid used. (A.A.D.)
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2007-01-01
countries in developing market nations in Asia (such as Korea, Taiwan, Singapore, Malaysia , China and Vietnam). The competition for the knowledge, economic...Intel, Infineon Technologies, STMicroelectronics, Samsung Electronics, Texas Instruments, AMD Spansion, Philips Semiconductor, Freescale... Samsung ($19.7B), #5 Toshiba ($9.8B), #6 TSMC ($9.7B), #7 Hynix ($8.0B) and #8 Renesas ($7.9B) (McGrath, 2007, p. 3). Samsung , headquartered in
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Case Study: Modelling Telecommunication Systems using Concurrent ML
DEFF Research Database (Denmark)
Hoffmann, Torben
1998-01-01
How can telecommunication hardware be modelled in CML. How are generalities and parallelism captured in CML.......How can telecommunication hardware be modelled in CML. How are generalities and parallelism captured in CML....
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International Nuclear Information System (INIS)
Laurian, Ion Mihai; Angelescu, T.; Lazanu, I.; Mihul, A.; Malace, S.; Haiduc, M.; Biasini, Maurizio; Santinelli, R.; Pioppi, M.
2002-01-01
The conservation of lepton number separately for each generation has no strong theoretical basis. LEP experiments have investigated the channels in the Z mass region and obtained a limit of about 95% confidence level. First results have been published by L3 Collaboration in 1993. New data at energies between 190 and 210 GeV have been obtained. These data have been analysed in order to search for events violating lepton flavour number in this energy range. (authors)
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Novel grading system for quantification of cystic macular lesions in Usher syndrome.
Sliesoraityte, Ieva; Peto, Tunde; Mohand-Said, Saddek; Sahel, Jose Alain
2015-12-10
To evaluate novel grading system used to quantify optical coherence tomography (OCT) scans for cystic macular lesions (CML) in Usher syndrome (USH) patients, focusing on CML associated alterations in MOY7A and USH2A mutations. Two readers evaluated 76 patients' (mean age 42 ± 14 years) data prospectively uploaded on Eurush database. OCT was used to obtain high quality cross-sectional images through the fovea. The CML was graded as none, mild, moderate or severe, depending on the following features set: subretinal fluid without clearly detectable CML boundaries; central macular thickness; largest diameter of CML; calculated mean of all detectable CML; total number of detectable CML; retinal layers affected by CML. Intra-and inter-grader reproducibility was evaluated. CML were observed in 37 % of USH eyes, while 45 % were observed in MYO7A and 29 % in USH2A cases. Of those with CML: 52 % had mild, 22 % had moderate and 26 % had severe changes, respectively. CML were found in following retinal layers: 50 % inner nuclear layer, 44 % outer nuclear layer, 6 % retinal ganglion cell layer. For the inter-grader repeatability analysis, agreements rates for CML were 97 % and kappa statistics was 0.91 (95 % CI 0.83-0.99). For the intra-grader analysis, agreement rates for CML were 98 %, while kappa statistics was 0.96 (95 % CI 0.92-0.99). The novel grading system is a reproducible tool for grading OCT images in USH complicated by CML, and potentially could be used for objective tracking of macular pathology in clinical therapy trials.
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Neutron-deuteron analyzing power data at 19.0 MeV
International Nuclear Information System (INIS)
Weisel, G. J.; Tornow, W.; Crowe, B. J. III; Crowell, A. S.; Esterline, J. H.; Howell, C. R.; Kelley, J. H.; Macri, R. A.; Pedroni, R. S.; Walter, R. L.; Witala, H.
2010-01-01
Measurements of neutron-deuteron (n-d) analyzing power A y (θ) at E n =19.0 MeV are reported at 16 angles from θ c.m. =46.7 to 152.0 deg. The objective of the experiment is to better characterize the discrepancies between n-d data and the predictions of three-nucleon calculations for neutron energies above 16.0 MeV. The experiment used a shielded neutron source, which produced polarized neutrons via the 2 H(d-vector,n-vector) 3 He reaction, a deuterated liquid scintillator center detector (CD) and liquid-scintillator neutron side detectors. A coincidence between the CD and the side detectors isolated the elastic-scattering events. The CD pulse height spectrum associated with each side detector was sorted by using pulse-shape discrimination, time-of-flight techniques, and by removing accidental coincidences. A Monte Carlo computer simulation of the experiment accounted for effects due to finite geometry, multiple scattering, and CD edge effects. The resulting high-precision data (with absolute uncertainties ranging from 0.0022 to 0.0132) have a somewhat lower discrepancy with the predictions of three-body calculations, as compared to those found at lower energies.
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DCS emulator development for the ACR-1000 simulator
International Nuclear Information System (INIS)
Nakashima, Y.; Trueman, R.; Ishii, K.
2010-01-01
Nuclear Power Plant (NPP) simulators are the main means for operator training and as such are a crucial part of the NPP operation life-cycle. Hitachi, Ltd., Information and Control Systems Company (henceforth 'Hitachi') is the preferred DCS and DCS emulator developer and supplier for the ACR-1000 NPP control system. Hitachi's concept for the DCS (distributed control system) portion of the ACR-1000 simulator is 'total emulation of the DCS' by software. This paper will review the current status of the technical development and the major project milestones. (author)
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Directory of Open Access Journals (Sweden)
Liu Z
2017-07-01
Full Text Available Zhihe Liu, Hongqiong Fan, Yuying Li, Chunshui Liu Department of Hematology, Cancer Center, The First Hospital of Jilin University, Changchun, People’s Republic of China Abstract: The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January 2010 to December 2014 were retrospectively recruited. Based on the platelet (PLT count, 22 patients were assigned into CML with thrombocytosis (CML-T group (PLT >1,000×109/L and 65 patients were classified into CML without extreme thrombocytosis (CML-N group (PLT ≤1,000×109/L. Fifty-four point five percent of patients in the CML-T group were female, which was higher than that in the CML-N group (27.7% (P=0.022. Except for gender, there was no significant difference for clinical information of patients between the two groups. For Sokal and Hasford scoring systems, the percentage of patients at high risk in the CML-T group were higher than those in the CML-N group, 95.5% vs 52.3% (P=0.000 and 68.2% vs 41.5% (P=0.031, respectively; however, there was no significant difference for European Treatment and Outcome Study (EUTOS score system between the two groups (P=0.213. In terms of major molecular response (MMR rate, the percent of patients with MMR in CML-T group was lower than that in CML-N group at 36 months after tyrosine kinase inhibitor therapy (P=0.037. Up until December 2016, the median of event-free survival was 21 months in the CML-T group, however, that was not reached in the CML-N group (P=0.027. The majority of CML patients with extreme thrombocytosis were females, and compared to patients in the CML-N group, the percentage of high risk patients based on the Sokal and Hasford scoring systems was higher in the CML-T group, and the median
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α-decay properties of 190Po and the identification of 191Po
International Nuclear Information System (INIS)
Batchelder, J.C.; Batchelder, J.C.; Zganjar, E.F.; Toth, K.S.; Bingham, C.R.; Bingham, C.R.; Wauters, J.; Brown, L.T.; Davids, C.N.; Seweryniak, D.; Brown, L.T.; Conticchio, L.F.; Seweryniak, D.; Conticchio, L.F.; Wood, J.L.
1997-01-01
The α-decay properties of 190 Po were investigated through the use of a fragment mass analyzer in conjunction with a double-sided Si strip detector. The isotope was produced via the 96 Mo( 96 Mo,2n) reaction, and its α-decay energy and T 1/2 were measured as 7529(10) keV and 2.4 -0.3 +0.4 ms, respectively. The resulting reduced width is nearly identical to that of the 192,194 Po isotopes. This is believed to result from significant mixing between the ground state π(2p) and the low-lying 0 + π(4p-2h) intruder state in the Po parent. The result provides further evidence for shape coexistence in the light Po isotopes. In addition, 191 Po was unambiguously identified, and the 186 Pb α-decay branch was determined experimentally for the first time. copyright 1997 The American Physical Society
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Schmidt, M; Hochhaus, A; König-Merediz, S A; Brendel, C; Proba, J; Hoppe, G J; Wittig, B; Ehninger, G; Hehlmann, R; Neubauer, A
2000-10-01
Mice experiments have established an important role for interferon regulatory factor (IRF) family members in hematopoiesis. We wanted to study the expression of interferon regulatory factor 4 (IRF4) in various hematologic disorders, especially chronic myeloid leukemia (CML), and its association with response to interferon alfa (IFN-alpha) treatment in CML. Blood samples from various hematopoietic cell lines, different leukemia patients (70 CML, 29 acute myeloid leukemia [AML], 10 chronic myelomonocytic leukemia [CMMoL], 10 acute lymphoblastic leukemia, and 10 chronic lymphoid leukemia patients), and 33 healthy volunteers were monitored for IRF4 expression by reverse transcriptase polymerase chain reaction. Then, with a focus on CML, the IRF4 level was determined in sorted cell subpopulations from CML patients and healthy volunteers and in in vitro-stimulated CML cells. Furthermore, IRF4 expression was compared in the CML samples taken before IFN-alpha therapy and in 47 additional CML samples taken during IFN-alpha therapy. IRF4 expression was then correlated with cytogenetic response to IFN-alpha. IRF4 expression was significantly impaired in CML, AML, and CMMoL samples. The downregulation of IRF4 in CML samples was predominantly found in T cells. In CML patients during IFN-alpha therapy, a significant increase in IRF4 levels was detected, and this was also observed in sorted T cells from CML patients. The increase seen during IFN-alpha therapy was not due to different blood counts. In regard to the cytogenetic response with IFN-alpha, a good response was associated with high IRF4 expression. IRF4 expression is downregulated in T cells of CML patients, and its increase is associated with a good response to IFN-alpha therapy. These data suggest IRF4 expression as a useful marker to monitor, if not predict, response to IFN-alpha in CML.
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Smartphones and Programmable Shunts: Are These Indispensable Phones Safe and Smart?
Ozturk, Sait; Cakin, Hakan; Kurtuldu, Huseyin; Kocak, Onur; Erol, Fatih S; Kaplan, Metin
2017-06-01
This study aimed to determine whether smartphones affect programmable shunts. iPhone 5S (Apple Inc., Cupertino, CA, USA) and Samsung Galaxy S5 (Samsung Electronics, Gumi, South Korea) smartphones were chosen for this study. For both phones, magnetic field mapping was performed with 3-dimensional magnetic scanning systems constructed with high-precision motorized stages, and a Hall effect sensor was used to measure the flux density on the smartphone surface. The distance (h) between the distal outlet of the reservoir and the rugby ball of the Strata valve (Medtronic Inc., Minneapolis, MN, USA) was measured using highly sensitive microanalysis optical method. During optical microanalysis, while keeping a 3-cm distance between the valve and the magnetic generator, the h value (μm) was recorded for different magnetic flux densities (MFDs). Then, direct x-ray radiography was performed for radiologic assessment after each process under different magnetic fields. For analysis of the Codman Certas valve (Codman Neuro, Raynham, MA, USA), the magnet orientation and the angle between the magnet with the tantalum ball were measured with the same optical analysis. Maximum MFDs found 62 G for iPhone 5S and 61 G for Samsung Galaxy S5. When the magnetic generator formed a current at 0, 30, 60, and 90 G, the h values of the Strata valve adjusted to 100 mm H 2 O opening pressure were 320, 280, 190, and 175 μm, respectively. When the magnetic generator was removed from the environment, the h value returned to 320 μm. In direct graphs taken after each optical analysis at different Gauss values, substitution was not observed at the indicator. The angle in the Codman Certas valve was 123.9°, 112.5°, and 103.6° at the magnetic flux densities of 0, 60, and 90 G, respectively. When the magnetic field was removed (0 G), the angle was still 103.6°, suggesting an irreversible effect in the shunt construct. Smartphones exert reversible effects on Strata programmable valves without
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190-C Facility <90 Day Storage Pad supplemental information to the Hanford facility contingency plan
International Nuclear Information System (INIS)
Little, N.C.
1996-12-01
The 190-C Facility <90 Day Storage Pad stores waste oils primarily contaminated with lead generated while draining equipment within the building of residual lubricating oils. Waste oils are packaged and stored in fifty-five gallon drums, or other containers permitted by the Site Specific Waste Management Instruction. Bechtel Hanford, Inc. (BHI) manual BHI-EE-02, Environmental Requirements Procedures, references this document. This document is to be used to demonstrate compliance with the contingency plan requirements in Washington Administrative Code, Chapter 173-303, Dangerous Waste Regulations, for certain Resource Conservation and Recovery Act of 1976 (RCRA) waste management units (units). Refer to BHI-EE-02, for additional information
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International Nuclear Information System (INIS)
Yu, Ligang; He, Zhiyong; Zeng, Maomao; Zheng, Zongping; Chen, Jie
2016-01-01
This study investigated the effects of irradiation on N ε -carboxymethyl-lysine (CML) and N ε -carboxyethyl-lysine (CEL) formation in cooked red and white meats during storage. The results showed that irradiation did not affect CML/CEL formation (0 weeks). After 6 weeks, CML/CEL contents in the irradiated samples exhibited a higher growth rate than the non-irradiated samples, especially the red meat. The results of electron spin resonance spectrometry and 2-Thiobarbituric acid-reactive substances suggested irradiation had induced free-radical reactions and accelerated lipid oxidation during storage. A linear correlation (r=0.810–0.906, p<0.01) was found between the loss of polyunsaturated fatty acids content and increase of CML/CEL content in the irradiated samples after 0 and 6 weeks of storage. The results indicate that irradiation-induced lipid oxidation promotes CML/CEL formation, and CML/CEL formation by the lipid oxidation pathways may be an important pathway for CML/CEL accumulation in irradiated meat products during storage. - Highlights: • The effect of irradiation on CML and CEL formation in meat products is investigated. • CML and CEL contents in irradiated meat products exhibit a higher growth rate than non-irradiated samples. • PUFAs oxidation induced by irradiation promotes CML and CEL formation. • Lipid oxidation pathways are an important pathway for CML and CEL accumulation in irradiated samples during storage.
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Operationalizing Mobile Applications for Humanitarian Assistance/Disaster Relief Missions
2014-03-01
the Samsung Galaxy SII (i9100) if it is the Unlocked GSM International Version that runs Gingerbread 2.3.4 OS; the 8 Samsung Nexus S if it is the...runs Gingerbread 2.3.4 OS (Naval Postgraduate School, 2013). Likewise he software can also be run on tablets, including the Samsung Galaxy Tab 7...Concept of FIST The FIST application was created to function in numerous diverse environments to support various possible missions, such as
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JPRS Report, Soviet Union, International Affairs
1990-07-06
household appliances. " Samsung " has divisions in the USA and Mexico, England, Portugal and Spain, Thailand and Malaysia . Construction of four new... Samsung Corporation. Samsung —"Three Stars"—unites 37 companies of dif- ferent description which produce textiles and sugar, build ships, hotels and...nition throughout the world primarily for its broad spectrum of electronic products. Out of 150,000 employees (the ratio of "blue" to "white" collar
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The effectiveness of heat pumps as part of CCGT-190/220 Tyumen CHP-1
Directory of Open Access Journals (Sweden)
Tretyakova Polina
2017-01-01
Full Text Available The article considers the possibility of increasing the energy efficiency of CCGT-190/220 Tyumen CHP-1 due to the utilization of low-grade heat given off in the condenser unit of the steam turbine. To assess the effectiveness of the proposed system, the indexes of thermal efficiency are given. As a result of a research the following conclusions are received: The heat-transfer agent heat pump, when heated uses low-grade heat TPP and increases heat output, but consumes the electricity. Using a heat pump is effective for a small temperature difference between the condenser and the evaporator. Good example is heating water before chemical treatment. This method is more efficient than using a replacement boiler and it is used in steam selection.
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Fundamental BOP I and C systems structure in nuclear power plants
International Nuclear Information System (INIS)
Ishii, K.; Harada, H.; Yamamori, T.; Igarashi, K.; Arakida, T.
2008-01-01
Digital instrumentation and control (I and C) systems using distributed control systems (DCS) are essential elements for nuclear power plants (NPPs) seeking higher reliability, availability and maintainability. Hitachi can boast its broad new build and refurbishment project experience in Japan and other markets since the 1970s. Throughout its continuous involvement in NPP design, fabrication, construction and maintenance over 30 years, Hitachi has increasingly integrated digital I and C system with its own DCS suite. This paper focuses on the fundamental characteristics of Hitachi's Balance of Plant (BOP) I and C systems structure for new build nuclear projects. (author)
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Koinuma, Shingo; Takeuchi, Kohei; Wada, Naoyuki; Nakamura, Takeshi
2017-11-01
Cyclic AMP plays a pivotal role in neurite growth. During outgrowth, a trafficking system supplies membrane at growth cones. However, the cAMP-induced signaling leading to the regulation of membrane trafficking remains unknown. TC10 is a Rho family GTPase that is essential for specific types of vesicular trafficking. Recent studies have shown a role of TC10 in neurite growth in NGF-treated PC12 cells. Here, we investigated a mechanical linkage between cAMP and TC10 in neuritogenesis. Plasmalemmal TC10 activity decreased abruptly after cAMP addition in neuronal cells. TC10 was locally inactivated at extending neurite tips in cAMP-treated PC12 cells. TC10 depletion led to a decrease in cAMP-induced neurite outgrowth. Constitutively active TC10 could not rescue this growth reduction, supporting our model for a role of GTP hydrolysis of TC10 in neuritogenesis by accelerating vesicle fusion. The cAMP-induced TC10 inactivation was mediated by PKA. Considering cAMP-induced RhoA inactivation, we found that p190B, but not p190A, mediated inactivation of TC10 and RhoA. Upon cAMP treatment, p190B was recruited to the plasma membrane. STEF depletion and Rac1-N17 expression reduced cAMP-induced TC10 inactivation. Together, the PKA-STEF-Rac1-p190B pathway leading to inactivation of TC10 and RhoA at the plasma membrane plays an important role in cAMP-induced neurite outgrowth. © 2017 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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Energy Technology Data Exchange (ETDEWEB)
Hao, Jiabin; Bai, Hongli; Liu, Jintao; Yang, Fangli; Li, Qiling; Su, Changwei [Key Laboratory of Comprehensive Utilization of Mineral Resources in Ethnic Regions, Yunnan Minzu University, Kunming 650500 (China); Key Laboratory of Resource Clean Conversion in Ethnic Regions, Education Department of Yunnan, Yunnan Minzu University, Kunming 650500 (China); Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500 (China); Guo, Junming, E-mail: guojunming@tsinghua.org.cn [Key Laboratory of Comprehensive Utilization of Mineral Resources in Ethnic Regions, Yunnan Minzu University, Kunming 650500 (China); Key Laboratory of Resource Clean Conversion in Ethnic Regions, Education Department of Yunnan, Yunnan Minzu University, Kunming 650500 (China); Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500 (China)
2016-05-25
A (Li, Cu)-co-doped cathode material Li(Li{sub 0.05}Cu{sub 0.05}Mn{sub 1.90})O{sub 4} was prepared by a flameless combustion synthesis at 500 °C for 3 h and then two-stage calcination at 700 °C for 6 h. Physical and electrochemical performances were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscope (TEM), galvanostatic charge–discharge cycling test, cyclic voltammogram (CV) and electrochemical impedance spectroscopy (EIS) to investigate the influence of Li and Cu substitution on the lithium ion batteries. Li(Li{sub 0.05}Cu{sub 0.05}Mn{sub 1.90})O{sub 4} not only exhibited the initial discharge capacity of 106.9 mAh g{sup −1} with a high retention of 89.2% after 500 cycles at 1.0 C but also retained 63.5% capacity after 1500 cycles at 5.0 C. Besides, a good rate capability at different current densities from 0.5 C to 5.0 C can be acquired. The (Li, Cu)-co-doped sample had excellent cycling stability in comparison with the LiMn{sub 2}O{sub 4} cathode. - Highlights: • A (Li, Cu)-co-doped Li(Li{sub 0.05}Cu{sub 0.05}Mn{sub 1.90})O{sub 4} was synthesized by a flameless combustion method. • The (Li, Cu)-co-doped Li(Li{sub 0.05}Cu{sub 0.05}Mn{sub 1.90})O{sub 4} has higher crystallinity. • Low level of Li and Cu doping exhibits better rate capability and cycling performance.
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Metabolic transit of N(ε)-carboxymethyl-lysine after consumption of AGEs from bread crust.
Roncero-Ramos, Irene; Delgado-Andrade, Cristina; Tessier, Frédéric J; Niquet-Léridon, Céline; Strauch, Christopher; Monnier, Vincent M; Navarro, María Pilar
2013-07-01
Our aim was to investigate carboxymethyl-lysine (CML) intake and excretion after feeding rats with diets containing advanced glycation end-products (AGEs) from bread crust (BC) or its soluble or insoluble fractions, and to identify the factors responsible for the effects observed. CML in serum and different tissues was measured to detect possible accumulations. For 88 days, weanling rats were fed with either a control diet or one containing BC, or its soluble low molecular weight (LMW), soluble high molecular weight (HMW) or insoluble fractions. In the last week of the assay, faeces and urine were collected daily and stored as a 1 week pool. After sacrifice, blood was drawn to obtain serum and some organs were removed. CML analysis was performed by HPLC/MS/MS in diets, faeces, urines, serum and tissues. Faecal excretion of CML was strongly influenced by dietary CML levels and represents the major route of excretion (i.e. 33.2%). However, the urinary elimination of CML was probably limited or saturated, especially when more complex compounds were present in the diet. BC consumption increased CML in the cardiac tissue (170 ± 18 vs. 97 ± 3 μmol per mol lysine for BC and control groups), which correlated with the CML intake. The levels of this AGE in bone were unaffected by the dietary treatment, but in tail tendons CML was greatly increased in the animals that consumed the BC diet (102 ± 13 vs. 51 ± 8 μmol per mol lysine for BC and control groups, P = 0.006), which was associated with the intake of soluble LMW compounds present in BC. Despite the CML accumulation detected in different tissues, serum levels of protein-bound CML were unchanged, indicating the importance of measuring the free CML in this fluid as a real index of dietary CML.
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Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells
Directory of Open Access Journals (Sweden)
Ahmad Hamad
2013-01-01
Full Text Available Chronic myeloid leukemia (CML is a clonal myeloproliferative disorder. Current targeted therapies designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein have made a significant breakthrough in the treatment of CML patients. However, CML remains a chronic disease that a patient must manage for life. Although tyrosine kinase inhibitors (TKI therapy has completely transformed the prognosis of CML, it has made the therapeutic management more complex. The interruption of TKI treatment results in early disease progression because it does not eliminate quiescent CML stem cells which remain a potential reservoir for disease relapse. This highlights the need to develop new therapeutic strategies for CML to achieve a permanent cure, and to allow TKI interruption. This review summarizes recent research done on alternative targeted therapies with a particular focus on some important signaling pathways (such as Alox5, Hedgehog, Wnt/b-catenin, autophagy, and PML that have the potential to target CML stem cells and potentially provide cure for CML.
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Naka, Kazuhito; Jomen, Yoshie; Ishihara, Kaori; Kim, Junil; Ishimoto, Takahiro; Bae, Eun-Jin; Mohney, Robert P.; Stirdivant, Steven M.; Oshima, Hiroko; Oshima, Masanobu; Kim, Dong-Wook; Nakauchi, Hiromitsu; Takihara, Yoshihiro; Kato, Yukio; Ooshima, Akira; Kim, Seong-Jin
2015-01-01
Understanding the specific survival of the rare chronic myelogenous leukaemia (CML) stem cell population could provide a target for therapeutics aimed at eradicating these cells. However, little is known about how survival signalling is regulated in CML stem cells. In this study, we survey global metabolic differences between murine normal haematopoietic stem cells (HSCs) and CML stem cells using metabolomics techniques. Strikingly, we show that CML stem cells accumulate significantly higher levels of certain dipeptide species than normal HSCs. Once internalized, these dipeptide species activate amino-acid signalling via a pathway involving p38MAPK and the stemness transcription factor Smad3, which promotes CML stem cell maintenance. Importantly, pharmacological inhibition of dipeptide uptake inhibits CML stem cell activity in vivo. Our results demonstrate that dipeptide species support CML stem cell maintenance by activating p38MAPK–Smad3 signalling in vivo, and thus point towards a potential therapeutic target for CML treatment. PMID:26289811
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Directory of Open Access Journals (Sweden)
Ilana de França Azevedo
2014-10-01
Full Text Available Objective: This study investigated the occurrence of the p190 and p210 break point clusterregion-Abelson (BCR-ABL rearrangements in adults with acute lymphoblastic leukemia and possible associations with clinical and laboratory characteristics and survival. Methods: Forty-one over 18-year-old patients with acute lymphoblastic leukemia of both genders followed-up between January 2008 and May 2012 were included in this study. Clinical and laboratory data were obtained from the medical charts of the patients. Reverse transcription polymerase chain reaction (RT-PCR using specific primers was employed to identify molecular rearrangements. Results: At diagnosis, the median age was 33 years, and there was a predominance of males (61%. The most common immunophenotype was B lineage (76%. BCR-ABL rearrangements was detected in 14 (34% patients with the following distribution: p190 (28%, p210 (50% and double positive (22%. Overall survival of patients with a mean/median of 331/246 days of follow up was 39%, respectively, negative BCR-ABL (44% and positive BCR-ABL (28%. Conclusion: These results confirm the high frequency of BCR-ABL rearrangements and the low survival rate of adult Brazilian patients with acute lymphoblastic leukemia.
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Jabbour, Elias J; Cortes, Jorge E; Kantarjian, Hagop M
2014-01-01
Chronic myeloid leukemia (CML) is a hematologic neoplasm with a progressive, ultimately terminal, disease course. In most cases, CML arises owing to the aberrant formation of a chimeric gene for a constitutively active tyrosine kinase. Inhibition of the signaling activity of this kinase has proved to be a highly successful treatment target transforming the prognosis of patients with CML. New tyrosine kinase inhibitors (TKIs) continue to improve the management of CML, offering alternative options for those resistant to or intolerant of standard TKIs. Here we review the pathobiology of CML and explore emerging strategies to optimize the management of chronic-phase CML, particularly first-line treatment. PMID:24236822
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Kutseõppurid saavad peagi esimesed digipassid / Kerli Onno
Onno, Kerli
2016-01-01
Programmist Samsung DigiPass, mis lihtsustab noorte tööturule sisenemist. Programmi korraldab Samsung Electronics Baltics koostöös Tallinna ülikooli ja Eesti noorteühenduste liidu, haridus- ja teadusministeeriumi ning UNESCO-ga
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Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes
Beyan, Huriya; Riese, Harriette; Hawa, Mohammed I.; Beretta, Guisi; Davidson, Howard W.; Hutton, John C.; Burger, Huibert; Schlosser, Michael; Snieder, Harold; Boehm, Bernhard O.; Leslie, R. David
2012-01-01
In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum Nε-carboxymethyl-lysine (CML), an advanced glycation end product, is associated with proinflammation. We assessed whether serum CML and autoantibodies predicted type 1 diabetes and to what extent they were determined by genetic or environmental factors. Of 7,287 unselected schoolchildren screened, 115 were ICA+ and were tested for baseline CML and diabetes autoantibodies and followed (for median 7 years), whereas a random selection (n = 2,102) had CML tested. CML and diabetes autoantibodies were determined in a classic twin study of twin pairs discordant for type 1 diabetes (32 monozygotic, 32 dizygotic pairs). CML was determined by enzyme-linked immunosorbent assay, autoantibodies were determined by radioimmunoprecipitation, ICA was determined by indirect immunofluorescence, and HLA class II genotyping was determined by sequence-specific oligonucleotides. CML was increased in ICA+ and prediabetic schoolchildren and in diabetic and nondiabetic twins (all P < 0.001). Elevated levels of CML in ICA+ children were a persistent, independent predictor of diabetes progression, in addition to autoantibodies and HLA risk. In twins model fitting, familial environment explained 75% of CML variance, and nonshared environment explained all autoantibody variance. Serum CML, a glycotoxin, emerged as an environmentally determined diabetes risk factor, in addition to autoimmunity and HLA genetic risk, and a potential therapeutic target. PMID:22396204
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Hochhaus, Andreas; le Coutre, Philipp D.; Rosti, Gianantonio; Pinilla-Ibarz, Javier; Jabbour, Elias; Gillis, Kathryn; Woodman, Richard C.; Blakesley, Rick E.; Giles, Francis J.; Kantarjian, Hagop M.; Baccarani, Michele
2011-01-01
Nilotinib has significant efficacy in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) and in patients with CML-CP or CML in accelerated phase (CML-AP) after imatinib failure. We investigated the occurrence of cross-intolerance to nilotinib in imatinib-intolerant patients with CML. Only 1/75 (1%) patients with nonhematologic imatinib intolerance experienced a similar grade 3/4 adverse event (AE), and 3/75 (4%) experienced a similar persistent grade 2 nonhematologic AE on nilotinib. Only 7/40 (18%) patients with hematologic imatinib intolerance discontinued nilotinib, all because of grade 3/4 thrombocytopenia. Ninety percent of imatinib-intolerant patients with CML-CP who did not have complete hematologic response (CHR) at baseline (n = 52) achieved CHR on nilotinib. Nilotinib induced a major cytogenetic response in 66% and 41% of patients with imatinib-intolerant CML-CP and CML-AP (complete cytogenetic response in 51% and 30%), respectively. Minimal cross-intolerance was confirmed in patients with imatinib-intolerant CML. The favorable tolerability of nilotinib in patients with imatinib intolerance leads to alleviation of AE-related symptoms and significant and durable responses. In addition to its established clinical benefit in patients with newly diagnosed CML and those resistant to imatinib, nilotinib is effective and well-tolerated for long-term use in patients with imatinib intolerance. This study is registered at http://www.clinicaltrials.gov as NCT00471497 PMID:21467546
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International Nuclear Information System (INIS)
Dracoulis, G.D.; Lane, G.J.; Byrne, A.P.; Watanabe, H.; Hughes, R.O.; Kondev, F.G.; Carpenter, M.P.; Janssens, R.V.F.; Lauritsen, T.; Lister, C.J.; Seweryniak, D.; Zhu, S.; Chowdhury, P.; Shi, Y.; Xu, F.R.
2014-01-01
Recent results on high-spin isomers populated in deep-inelastic reactions in the transitional tungsten-osmium region are outlined with a focus on 190 Os, 192 Os and 194 Os. As well as the characterization of several two-quasineutron isomers, the 12 + and 20 + isomers in 192 Os are interpreted as manifestations of maximal rotation alignment within the neutron i(13/2) and possibly proton h(11/2) shells at oblate deformation. (authors)
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A Percepção dos Fatores de Erosão no Processo de Construção da Marca Samsung no Brasil
Directory of Open Access Journals (Sweden)
Camila da Silva Schmitt
2016-12-01
Full Text Available Devido a hipercompetitividade no mercado, a preocupação e necessidade de se planejar adequadamente as estratégias mercadológicas são essenciais (Too, Harvey & Too, 2010. Nesse domínio as marcas são utilizadas pelas empresas como estratégia para criar valor e diferenciação, para que possam se distanciar dessa concorrência. Marcas fortes tendem a criar uma vantagem competitiva duradoura (Tavares, 1998; Bedbury, 2002; Keller & Machado, 2006; Aaker, 2007; Scharf, 2007. Porém, mesmo consolidadas no mercado, marcas sólidas estão vulneráveis aos fatores que causam sua erosão. Nesse contexto, este artigo pretendeu estabelecer a percepção dos fatores de erosão no processo de construção de marcas sólidas, analisando as ações estratégicas incorporadas e trabalhadas pela marca Samsung no Brasil. Para responder as indagações ostentadas, foram utilizados dados primários instaurados nas entrevistas realizadas com executivos estrategistas da marca, e informações advindas também de dados secundários com análise documental de artigos publicados sobre a marca investigada. Quanto aos fatores de erosão estabelecidos, alguns foram percebidos integralmente como erosivo pelos executivos, como é o caso da Proliferação de concorrentes e Pressão por resultados a curto prazo. Com a análise das informações se abarcou o estabelecimento de outros fatores que causam erosão na perspectiva de marca no contexto brasileiro.
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SiRen: Leveraging Similar Regions for Efficient and Accurate Variant Calling
2015-05-30
Cloudera, EMC2, Ericsson, Facebook, Guavus, HP, Huawei, Informatica , Intel, Microsoft, NetApp, Pivotal, Samsung, Schlumberger, Splunk, Virdata and VMware...EMC2, Ericsson, Facebook, Guavus, HP, Huawei, Informatica , Intel, Microsoft, NetApp, Pivotal, Samsung, Schlumberger, Splunk, Virdata and VMware
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Pilli, Tania; Cantara, Silvia; Marzocchi, Carlotta; Cardinale, Sandro; Santini, Chiara; Cevenini, Gabriele; Pacini, Furio
2017-08-01
It has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy. The present study aimed to validate these results in a larger cohort of patients. This study prospectively analyzed 1000 patients. Cytological diagnosis was available in 982/1000 (98.2%) and histological diagnosis in 445/1000 (44.5%). The expression levels of circulating miRNA-190 and -95 were determined by real time polymerase chain reaction with the 2 -ΔΔct method. The diagnostic performance (sensitivity, specificity, and accuracy) of fine-needle aspiration cytology (FNAC), pmiRNA, and a combination of the two methods was correlated with the cytological and histological diagnoses. The combination of pmiRNA and FNAC significantly increased the sensitivity (96.3%) with respect to each method alone (88.9% for FNAC and 89.6% for pmiRNA) by reducing the rate of false-negative results from 18 for FNAC and 17 for pmiRNA to only five. In patients in whom FNAC was not performed (n = 14) or in those with inadequate (n = 18) or indeterminate (n = 72) lesions submitted to surgery, pmiRNA correctly identified 90.8% of patients with benign disease and 74.3% of patients with cancer. These results confirm that a combination of serum expression levels of miRNA-95 and -190 is an accurate and noninvasive tool for the differential diagnosis of thyroid nodules in the Italian population.
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DEFF Research Database (Denmark)
Madsen, B K; Videbaek, R; Stokholm, H
1996-01-01
Survival in 190 consecutive patients with congestive heart failure, discharged from a general hospital, was studied. Sixteen patients were in New York Heart Association (NYHA) class I, 87 in II, 83 in III and 4 in IV. Median left ventricular ejection fraction (LVEF) from radionuclide...
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International Nuclear Information System (INIS)
Shalaby, A.S.
2005-01-01
Using the three-parameter expression of harris expansion of the rotational energy, the dynamical moment of inertia is represented by a power-series expansion in even powers of the rotational frequency. The three expansion coefficients were determined by using Marquardt method of nonlinear least-squares routines, to fit the proposed dynamical moment of inertia with its recent experimental data for the superdeformed (SD) nuclei in the A 190 mass region. The calculated dynamical moment of inertia with the best parameters is then integrated to obtain the spin, which in turn was used to determine the static moment of inertia. The comparison of the dynamic moment of inertia and spin with their available experimental data shows good agreements between them. These procedures were succeedingly done for nine superdeformed bands in the A 190 nuclei: 1 90Hg(B1, B3), 1 94PB(B1, B2, B3), 1 96PB(B1, B2, B3), 1 94PB(B1, B22, B3), 1 96BP((B1, B2, B3) and 1 98PO. We have also investigated the identity exist among these SD bands. It was shown that some of these SD bands are identical to each other
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Directory of Open Access Journals (Sweden)
Bing Li
2012-10-01
Full Text Available Nε-(carboxymethyl lysine (CML is the most abundant advanced glycation end product (AGE, and frequently selected as an AGEs marker in laboratory studies. In this paper, the formation and inhibition of Nε-(carboxymethyllysine in saccharide-lysine model systems during microwave heating have been studied. The microwave heating treatment significantly promoted the formation of CML during Maillard reactions, which was related to the reaction temperature, time and type of saccharide. The order of CML formation for different saccharides was lactose > glucose > sucrose. Then, the inhibition effect on CML by five inhibitors was further examined. According to the results, ascorbic acid and tocopherol did not affect inhibition of CML, in contrast, thiamin, rutin and quercetin inhibited CML formation, and the inhibitory effects were concentration dependent.
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Directory of Open Access Journals (Sweden)
Wiwik Melwinda
2017-04-01
Full Text Available This research aims to find out laptop brand selection perceptual map of among Telkom University students. The object of this research study are some of incoming laptop brand in Top Brand 2016 which are Acer, Lenovo, Asus, Toshiba, HP, Samsung and Apple. The attributes of the study are design instrument, operation system, variation, feature set, specification, processor, battery resistance, product price, price resale, warranty, LCD display, storage capacity, product quality, sustainability to defect, and keyboard quality. This research used quantitative method. Research instrument used was a questionnaire, which distributed to 100 respondent sample area of the object of research. In taking a sample of this study, the researcher used Non-Probability technique by using purposive sampling method. The data analysis that used is multidimensional scalling analysis, this analysis gives perception map picture, appeared the position of each laptop brand that is close together or far apart. Laptop brand that showed in a perceptual map will display rank of the best position than another laptop brand. As perception, Apple occupies the first best position among another best laptop brands. That is proved by the rank position from respondents preference based on overall attributes which is more excellent in design, operation system, variation, feature set, specification, processor, battery resistance, product quality, and keyboard quality. For price product attribute is occupied by Lenovo as the cheapest rather than another laptop brands. Meanwhile, for the LCD display attribute, price resale, and storage capacity are occupied by Asus which get the second best rank based overall attribute.
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77 FR 41919 - Hearing Aid Compatibility Technical Standard
2012-07-17
... equipment can be developed and the relevant tests applied. In particular, Samsung Telecommunications America, LLC (Samsung) states that guidelines are required to facilitate use of the Modulation Interference... that a two-year period will appropriately accommodate their design, engineering, and marketing needs as...
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Directory of Open Access Journals (Sweden)
Luz M Morera Barrios
2003-12-01
Full Text Available Se estudió la histocompatibilidad de los loci ABC y del locus D del sistema principal de histocompatibilidad mediante las técnicas serológicas de microlinfocitotoxicidad en 383 pacientes con diferentes enfermedades hematológicas. Se realizó una comparación por la técnica celular y la reactividad linfocitaria en el cultivo mixto de linfocitos (CML, en 39 de los 145 individuos idénticos para los antígenos HLA, tomados de los estudios familiares realizados en el IHI. Resultaron 29 CML negativos, para el 74,35 %. No se corresponden en el 100 % los estudios serológicos y celulares, ya que no se compatibilizó en todos los casos para los antígenos HLA de clase II, y en ninguno para los antígenos menores de histocompatibilidad, que influyen tanto en los resultados del CML y en las causas de fracaso del trasplante de médula ósea (TMO en individuos idénticos. Esto corrobora la importancia de los estudios de tipificación de biología molecular y antígenos menores de histocompatibilidadCompatibility study by serological (HLA and cellular methods (MLC during 22 years of work at the Institute of Hematology and Immunology The histocompatibility of the loci ABC and of the locus D of the main histocompatibility system was studied by the serological techniques of microlymphocytoxicity in 383 patients with different hematological diseases. A comparison was made in 39 of the 145 identical individuals for the HLA antigens obtained from the family studies conducted at the Institute of Hematology and Immunology by using the cellular technique and the lymphocytary reactivity in the mixed lymphocyte culture (MLC. 29 MLC proved to be negative, accounting for 74.35 %. There was not a 100 % correspondance between the serological and cellular studies, since it was not compatibilized in all cases for class II HLA antigens and in no case for the minor histocompatibility antigens that influence on the results of the MLC and on the causes of the failure of
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Laboratory tools for diagnosis and monitoring response in patients with chronic myeloid leukemia.
Tohami, Tali; Nagler, Arnon; Amariglio, Ninette
2012-08-01
Chronic myeloid leukemia (CML) is a clonal hematological disease that represents 15-20% of all adult leukemia cases. The study and treatment of CML has contributed pivotal advances to translational medicine and cancer therapy. The discovery that a single chromosomal abnormality, the Philadelphia (Ph) chromosome, is responsible for the etiology of this disease was a milestone for treating and understanding CML. Subsequently, CML became the first disease for which allogeneic bone marrow transplantation is the treatment of choice. Currently, CML is one of the few diseases where treatment targeted against the chromosomal abnormality is the sole frontline therapy for newly diagnosed patients. The use of directed therapy for CML challenged disease monitoring during treatment and led to the development of definitions that document response and predict relapse sooner than the former routine methods. These methods relied on classical cytogenetics through molecular cytogenetics (FISH) and, finally, on molecular monitoring assays. This review discusses the laboratory tools used for diagnosing CML, for monitoring during treatment, and for assessing remission or relapse. The advantages and disadvantages of each test, the common definition of response levels, and the efforts to standardize molecular monitoring for CML patient management are discussed.
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Re-emergence of interferon-α in the treatment of chronic myeloid leukemia
Talpaz, M; Hehlmann, R; Quintás-Cardama, A; Mercer, J; Cortes, J
2013-01-01
Treatment for chronic myeloid leukemia (CML) has evolved from chemotherapy (busulfan, hydroxyurea) to interferon-α (IFNα), and finally to tyrosine kinase inhibitors such as imatinib. Although imatinib has profoundly improved outcomes for patients with CML, it has limitations. Most significantly, imatinib cannot eradicate CML primitive progenitors, which likely accounts for the high relapse rate when imatinib is discontinued. IFNα, unlike imatinib, preferentially targets CML stem cells. Early studies with IFNα in CML demonstrated its ability to induce cytogenetic remission. Moreover, a small percentage of patients treated with IFNα were able to sustain durable remissions after discontinuing therapy and were probably cured. The mechanisms by which IFNα exerts its antitumor activity in CML are not well understood; however, activation of leukemia-specific immunity may have a role. Some clinical studies have demonstrated that the combination of imatinib and IFNα is superior to either therapy alone, perhaps because of their different mechanisms of action. Nonetheless, the side effects of IFNα often impede its administration, especially in combination therapy. Here, we review the role of IFNα in CML treatment and the recent developments that have renewed interest in this once standard therapy for patients with CML. PMID:23238589
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Ni, Xinzhi; Krakowsky, Matthew D; Buntin, G David; Rector, Brian G; Guo, Baozhu; Snook, Maurice E
2008-08-01
Ninety four corn inbred lines selected from International Center for the Improvement of Maize and Wheat (CIMMYT) in Mexico were evaluated for levels of silk maysin in 2001 and 2002. Damage by major ear-feeding insects [i.e., corn earworm, Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae); maize weevil, Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae); brown stink bug, Euschistus servus (Say); southern green stink bugs, Nezara viridula (L.) (Heteroptera: Pentatomidae)], and common smut [Ustilago maydis DC (Corda)] infection on these inbred lines were evaluated in 2005 and 2006 under subtropical conditions at Tifton, GA. Ten inbred lines possessing good agronomic traits were also resistant to the corn earworm. The correlation between ear-feeding insect damage or smut infection and three phenotypic traits (silk maysin level, husk extension, and husk tightness of corn ears) was also examined. Corn earworm and stink bug damage was negatively correlated to husk extension, but not to either silk maysin levels or husk tightness. In combination with the best agronomic trait ratings that show the least corn earworm and stink bug damage, lowest smut infection rate, and good insect-resistant phenotypic traits (i.e., high maysin and good husk coverage and husk tightness), 10 best inbred lines (CML90, CML92, CML94, CML99, CML104, CML108, CML114, CML128, CML137, and CML373) were identified from the 94 lines examined. These selected inbred lines will be used for further examination of their resistance mechanisms and development of new corn germplasm that confers multiple ear-colonizing pest resistance.
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Frolova, Olga; Benito, Juliana; Brooks, Chris; Wang, Rui-Yu; Korchin, Borys; Rowinsky, Eric K.; Cortes, Jorge; Kantarjian, Hagop; Andreeff, Michael; Frankel, Arthur E.; Konopleva, Marina
2014-01-01
SUMMARY While imatinib and other tyrosine kinase inhibitors (TKIs) are highly efficacious in the treatment of chronic myeloid leukaemia (CML), some patients become refractory to these therapies. After confirming that interleukin-3 receptor (IL3R, CD123) is highly expressed on CD34+/CD38− BCR-ABL1+ CML stem cells, we investigated whether targeting IL3R with diphtheria toxin (DT)-IL3 fusion proteins SL-401 (DT388-IL3) and SL-501 (DT388-IL3[K116W]) could eradicate these stem cells. SL-401 and SL-501 inhibited cell growth and induced apoptosis in the KBM5 cell line and its TKI-resistant KBM5-STI subline. Combinations of imatinib with these agents increased apoptosis in KBM5 and in primary CML cells. In six primary CML samples, including CML cells harbouring the ABL1 T315I mutation, SL-401 and SL-501 decreased the absolute numbers of viable CD34+/CD38−/CD123+ CML progenitor cells by inducing apoptosis. IL3-targeting agents reduced clonogenic growth and diminished the fraction of primitive long-term culture-initiating cells in samples from patients with advanced phase CML that were resistant to TKIs or harboured an ABL1 mutation. Survival was also extended in a mouse model of primary TKI-resistant CML blast crisis. These data suggest that the DT-IL3 fusion proteins, SL-401 and SL-501, deplete CML stem cells and may increase the effectiveness of current CML treatment, which principally targets tumour bulk. PMID:24942980
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Liu, Shing Hwa; Sheu, Wayne Huey Herng; Lee, Maw Rong; Lee, Wen Jane; Yi, Yu Chiao; Yang, Tzung Jie; Jen, Jen Fon; Pan, Hung Chuan; Shen, Chin Chang; Chen, Wen Bao; Tien, Hsing Ru; Sheu, Meei Ling
2013-06-01
N(ε)-carboxymethyllysine (CML), a major advanced glycation end product, plays a crucial role in diabetes-induced vascular injury. The roles of protein tyrosine phosphatases and vascular endothelial growth factor (VEGF) receptors in CML-related endothelial cell injury are still unclear. Human umbilical vein endothelial cells (HUVECs) are a commonly used human EC type. Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury. CML significantly inhibited cell proliferation and induced apoptosis and reduced VEGFR-2 activation in parallel with the increased SHP-1 protein expression and activity in HUVECs. Adding recombinant VEGF increased forward biological effects, which were attenuated by CML. The effects of CML on HUVECs were abolished by SHP-1 siRNA transfection. Exposure of HUVECs to CML also remarkably escalated the integration of SHP-1 with VEGFR-2. Consistently, SHP-1 siRNA transfection and pharmacological inhibitors could block this interaction and elevating [(3)H]thymidine incorporation. CML also markedly activated the NADPH oxidase and ROS production. The CML-increased SHP-1 activity in HUVECs was effectively attenuated by antioxidants. Moreover, the immunohistochemical staining of SHP-1 and CML was increased, but phospho-VEGFR-2 staining was decreased in the aortic endothelium of streptozotocin-induced and high-fat diet-induced diabetic mice. We conclude that a pathway of tyrosine phosphatase SHP-1-regulated VEGFR-2 dephosphorylation through NADPH oxidase-derived ROS is involved in the CML-triggered endothelial cell dysfunction/injury. These findings suggest new insights into the development of therapeutic approaches to reduce diabetic vascular complications. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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RhoA: A therapeutic target for chronic myeloid leukemia
Directory of Open Access Journals (Sweden)
Molli Poonam R
2012-03-01
Full Text Available Abstract Background Chronic Myeloid Leukemia (CML is a malignant pluripotent stem cells disorder of myeloid cells. In CML patients, polymorphonuclear leukocytes (PMNL the terminally differentiated cells of myeloid series exhibit defects in several actin dependent functions such as adhesion, motility, chemotaxis, agglutination, phagocytosis and microbicidal activities. A definite and global abnormality was observed in stimulation of actin polymerization in CML PMNL. Signalling molecules ras and rhoGTPases regulate spatial and temporal polymerization of actin and thus, a broad range of physiological processes. Therefore, status of these GTPases as well as actin was studied in resting and fMLP stimulated normal and CML PMNL. Methods To study expression of GTPases and actin, Western blotting and flow cytometry analysis were done, while spatial expression and colocalization of these proteins were studied by using laser confocal microscopy. To study effect of inhibitors on cell proliferation CCK-8 assay was done. Significance of differences in expression of proteins within the samples and between normal and CML was tested by using Wilcoxon signed rank test and Mann-Whitney test, respectively. Bivariate and partial correlation analyses were done to study relationship between all the parameters. Results In CML PMNL, actin expression and its architecture were altered and stimulation of actin polymerization was absent. Differences were also observed in expression, organization or stimulation of all the three GTPases in normal and CML PMNL. In normal PMNL, ras was the critical GTPase regulating expression of rhoGTPases and actin and actin polymerization. But in CML PMNL, rhoA took a central place. In accordance with these, treatment with rho/ROCK pathway inhibitors resulted in specific growth inhibition of CML cell lines. Conclusions RhoA has emerged as the key molecule responsible for functional defects in CML PMNL and therefore can be used as a
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Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission
Directory of Open Access Journals (Sweden)
Agnes S. M. Yong
2017-04-01
Full Text Available Chronic myeloid leukemia (CML is a hematological cancer, characterized by a reciprocal chromosomal translocation between chromosomes 9 and 22 [t(9;22], producing the Bcr-Abl oncogene. Tyrosine kinase inhibitors (TKIs represent the standard of care for CML patients and exert a dual mode of action: direct oncokinase inhibition and restoration of effector-mediated immune surveillance, which is rendered dysfunctional in CML patients at diagnosis, prior to TKI therapy. TKIs such as imatinib, and more potent second-generation nilotinib and dasatinib induce a high rate of deep molecular response (DMR, BCR-ABL1 ≤ 0.01% in CML patients. As a result, the more recent goal of therapy in CML treatment is to induce a durable DMR as a prelude to successful treatment-free remission (TFR, which occurs in approximately half of all CML patients who cease TKI therapy. The lack of overt relapse in such patients has been attributed to immunological control of CML. In this review, we discuss an immunological timeline to successful TFR, focusing on the immunology of CML during TKI treatment; an initial period of immune suppression, limiting antitumor immune effector responses in newly diagnosed CML patients, linked to an expansion of immature myeloid-derived suppressor cells and regulatory T cells and aberrant expression of immune checkpoint signaling pathways, including programmed death-1/programmed death ligand-1. Commencement of TKI treatment is associated with immune system re-activation and restoration of effector-mediated [natural killer (NK cell and T cell] immune surveillance in CML patients, albeit with differing frequencies in concert with differing levels of molecular response achieved on TKI. DMR is associated with maximal restoration of immune recovery in CML patients on TKI. Current data suggest a net balance between both the effector and suppressor arms of the immune system, at a minimum involving mature, cytotoxic CD56dim NK cells may be important
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Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission
Hughes, Amy; Yong, Agnes S. M.
2017-01-01
Chronic myeloid leukemia (CML) is a hematological cancer, characterized by a reciprocal chromosomal translocation between chromosomes 9 and 22 [t(9;22)], producing the Bcr-Abl oncogene. Tyrosine kinase inhibitors (TKIs) represent the standard of care for CML patients and exert a dual mode of action: direct oncokinase inhibition and restoration of effector-mediated immune surveillance, which is rendered dysfunctional in CML patients at diagnosis, prior to TKI therapy. TKIs such as imatinib, and more potent second-generation nilotinib and dasatinib induce a high rate of deep molecular response (DMR, BCR-ABL1 ≤ 0.01%) in CML patients. As a result, the more recent goal of therapy in CML treatment is to induce a durable DMR as a prelude to successful treatment-free remission (TFR), which occurs in approximately half of all CML patients who cease TKI therapy. The lack of overt relapse in such patients has been attributed to immunological control of CML. In this review, we discuss an immunological timeline to successful TFR, focusing on the immunology of CML during TKI treatment; an initial period of immune suppression, limiting antitumor immune effector responses in newly diagnosed CML patients, linked to an expansion of immature myeloid-derived suppressor cells and regulatory T cells and aberrant expression of immune checkpoint signaling pathways, including programmed death-1/programmed death ligand-1. Commencement of TKI treatment is associated with immune system re-activation and restoration of effector-mediated [natural killer (NK) cell and T cell] immune surveillance in CML patients, albeit with differing frequencies in concert with differing levels of molecular response achieved on TKI. DMR is associated with maximal restoration of immune recovery in CML patients on TKI. Current data suggest a net balance between both the effector and suppressor arms of the immune system, at a minimum involving mature, cytotoxic CD56dim NK cells may be important in mediating
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2011-03-08
... Determinations: ``Poetry in Clay: Korean Buncheong Ceramics from the Leeum, Samsung Museum of Art'' SUMMARY... in Clay: Korean Buncheong Ceramics from the Leeum, Samsung Museum of Art,'' imported from abroad for temporary exhibition within the United States, are of cultural significance. The objects are imported...
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The Association between Fruit and Vegetable Intake and Liver ...
African Journals Online (AJOL)
GB
2017-07-01
Jul 1, 2017 ... Dietary intake data were analyzed using the NUTRITIONIST 4 (First Data. Bank, San Bruno, CA) food analyzer. Blood pressure measurement: Blood pressure was measured by the Automatic Inflate Blood. Pressure Monitor (Samsung BA507S automatic digital blood pressure monitor, Samsung America,.
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Erinevate GPS-funktsiooniga seadmete võrdlus metsanduses / Mikko Buht
Buht, Mikko
2014-01-01
2014. aastal kaitstud metsanduse eriala lõputöö põhjal. Töös kasutati kolme GPS-seadet: Garmin Oregon GPSMAP 60CSX, Magellan eXplorist 510 ja Garmin Oregon 600, samuti nutitelefoni Samsung Galaxy SII Plus ja tahvelarvutit Samsung Galaxy Note 10.1
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2012-03-26
....99.8060. Although the HTSUS subheadings are provided for convenience and customs purposes, the... methodology of calculating a weighted-average margin due to requests to protect business-proprietary... Presented at the Start of Samsung's Sales Verifications 27. Samsung's U.S. Rebates 28. Treatment of Payments...
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Oh, Hyung Geun; Nallamshetty, Shriram; Rhee, Eun Jung
2016-02-01
The waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of baseline WHtR and progression of coronary artery calcification (CAC) over 4 years of follow-up in apparently healthy Korean men. A total of 1,048 male participants (mean age, 40.9 years) in a health-screening program in Kangbuk Samsung Hospital, Seoul, Korea who repeated a medical check-up in 2010 and 2014 were recruited. Baseline WHtR was calculated using the value for the waist in 2010 divided by the value for height in 2010. The CAC score (CACS) of each subject was measured by multi-detector computed tomography in both 2010 and 2014. Progression of CAC was defined as a CACS change over 4 years greater than 0. During the follow-up period, progression of CAC occurred in 278 subjects (26.5%). The subjects with CAC progression had slightly higher but significant baseline WHtR compared to those who did not show CAC progression (0.51±0.04 vs. 0.50±0.04, P<0.01). The proportion of subjects with CAC progression significantly increased as the baseline WHtR increased from the 1st quartile to 4th quartile groups (18.3%, 18.7%, 28.8%, and 34.2%; P<0.01). The risk for CAC progression was elevated with an odds ratio of 1.602 in the 4th quartile group of baseline WHtR even after adjustment for confounding variables (95% confidence interval, 1.040 to 2.466). Increased baseline WHtR was associated with increased risk for CAC progression. WHtR might be a useful screening tool to identify individuals at high risk for subclinical atherosclerosis.
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Schiffer, Charles A; Cortes, Jorge E; Hochhaus, Andreas; Saglio, Giuseppe; le Coutre, Philipp; Porkka, Kimmo; Mustjoki, Satu; Mohamed, Hesham; Shah, Neil P
2016-05-01
The proliferation of clonal cytotoxic T-cells or natural killer cells has been observed after dasatinib treatment in small studies of patients with chronic myeloid leukemia (CML). The incidence of lymphocytosis and its association with response, survival, and side effects were assessed in patients from 3 large clinical trials. Overall, 1402 dasatinib-treated patients with newly diagnosed CML in chronic phase (CML-CP), CML-CP refractory/intolerant to imatinib, or with CML in accelerated or myeloid-blast phase were analyzed. Lymphocytosis developed in 32% to 35% of patients and persisted for >12 months. This was not observed in the patients who received treatment with imatinib. Dasatinib-treated patients in all stages of CML who developed lymphocytosis were more likely to achieve a complete cytogenetic response, and patients who had CML-CP with lymphocytosis were more likely to achieve major and deep molecular responses. Progression-free and overall survival rates were significantly longer in patients with CML-CP who were refractory to or intolerant of imatinib and had lymphocytosis. Pleural effusions developed more commonly in patients with lymphocytosis. Overall, lymphocytosis occurred and persisted in many dasatinib-treated patients in all phases of CML. Its presence was associated with higher response rates, significantly longer response durations, and increased overall survival, suggesting an immunomodulatory effect. Prospective studies are warranted to characterize the functional activity of these cells and to assess whether an immunologic effect against CML is detectable. Cancer 2016;122:1398-1407. © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
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The option value of innovative treatments in the context of chronic myeloid leukemia.
Sanchez, Yuri; Penrod, John R; Qiu, Xiaoli Lily; Romley, John; Thornton Snider, Julia; Philipson, Tomas
2012-11-01
To quantify in the context of chronic myeloid leukemia (CML) the additional value patients receive when innovative treatments enable them to survive until the advent of even more effective future treatments (ie, the "option value"). Observational study using data from the Surveillance, Epidemiology and End Results (SEER) cancer registry comprising all US patients with CML diagnosed between 2000 and 2008 (N = 9,760). We quantified the option value of recent breakthroughs in CML treatment by first conducting retrospective survival analyses on SEER data to assess the effectiveness of TKI treatments, and then forecasting survival from CML and other causes to measure expected future medical progress. We then developed an analytical framework to calculate option value of innovative CML therapies, and used an economic model to value these gains. We calculated the option value created both by future innovations in CML treatment and by medical progress in reducing background mortality. For a recently diagnosed CML patient, the option value of innovative therapies from future medical innovation amounts to 0.76 life-years. This option value is worth $63,000, equivalent to 9% of the average survival gains from existing treatments. Future innovations in CML treatment jointly account for 96% of this benefit. The option value of innovative treatments has significance in the context of CML and, more broadly, in disease areas with rapid innovation. Incorporating option value into traditional valuations of medical innovations is both a feasible and a necessary practice in health technology assessment.
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Совершенствование системы мотивации персонала в торговой организации Samsung
Турыгина, А. А.
2017-01-01
Проблема исследования: необходима разработка мероприятий по совершенствованию системы мотивации персонала в магазине «Samsung» с целью повышения эффективности деятельности организации. Целью выпускной квалификационной работы является изучение системы мотивации персонала магазина «Samsung» и разработка мероприятий по ее совершенствованию. Объект исследования: система мотивации персонала. Предмет исследования: совершенствование системы мотивации персонала в магазине «Samsung». Структура работы....
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Совершенствование системы мотивации персонала в торговой организации Samsung
Турыгина, А. А.
2017-01-01
Проблема исследования: необходима разработка мероприятий по совершенствованию системы мотивации персонала в магазине «Samsung» с целью повышения эффективности деятельности организации. Целью выпускной квалификационной работы является изучение системы мотивации персонала магазина «Samsung» и разработка мероприятий по ее совершенствованию/Объект исследования: система мотивации персонала. Предмет исследования: совершенствование системы мотивации персонала в магазине «Samsung».Структура работы. Р...
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Mak, Po Yee; Mu, Hong; Zhou, Hongsheng; Mak, Duncan H.; Schober, Wendy; Leverson, Joel D.; Zhang, Bin; Bhatia, Ravi; Huang, Xuelin; Cortes, Jorge; Kantarjian, Hagop; Konopleva, Marina
2016-01-01
BCR-ABL tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML), but they rarely eliminate CML stem cells. Disease relapse is common upon therapy cessation, even in patients with complete molecular responses. Furthermore, once CML progresses to blast crisis (BC), treatment outcomes are dismal. We hypothesized that concomitant targeting of BCL-2 and BCR-ABL tyrosine kinase could overcome these limitations. We demonstrate increased BCL-2 expression at the protein level in bone marrow cells, particularly in Lin−Sca-1+cKit+ cells of inducible CML in mice as determined by CyTOF mass cytometry. Further, selective inhibition of BCL-2, aided by TKI-mediated MCL-1 and BCL-XL inhibition, markedly decreased leukemic Lin−Sca-1+cKit+ cell numbers and long-term stem cell frequency, and prolonged survival in a murine CML model. Additionally, this combination effectively eradicated CD34+CD38−, CD34+CD38+, and quiescent stem/progenitor CD34+ cells from BC CML patient samples. Our results suggest that BCL-2 is a key survival factor for CML stem/progenitor cells and that combined inhibition of BCL-2 and BCR-ABL tyrosine kinase has the potential to significantly improve depth of response and cure rates of chronic phase and BC CML. PMID:27605552
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Hydrothermal studies in a new diamond anvil cell up to 10 GPa and from -190°C to 1200°C
Bassett, W. A.; Shen, A. H.; Bucknum, M.; Chou, I.-Ming
1993-06-01
The new hydrothermal diamond anvil cell (HDAC) has been designed for optical microscopy and X-ray diffraction at pressures up to 10 GPa and temperatures between -190°C and 1200°C. Laser light reffected from the top and bottom anvil faces and the top and bottom solid sample faces produce interference fringes that provide a very sensitive means of monitoring the volume of sample chamber and for observing volume and refractive index changes in solid samples due to transitions and reactions. Synchrotron radiation has been used to make X-ray diffraction patterns of samples under hydrothermal conditions. Individual heaters and individual thermocouples provide temperature control with an accuracy of ±0.5°C. Liquid nitrogen directly introduced into the HDAC has been used to reduce the sample temperature to -190°C. The α-β phase boundary of quartz has been used to calculate the transition pressures from measured transition temperatures. With this method we have redetermined 5 isochores of H2O up to 850°C and 1.2 GPa at which the solution rate of the quartz became so rapid that the quartz dissolved completely before the α-β transition could be observed. When silica solutions were cooled, opal spherules and rods formed.
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2011-06-02
... operational characteristics similar to the commercial multi-split products manufactured by Mitsubishi, Samsung... reducing its operating capacity to as little as 10% of its rated capacity. Zone diversity enables AIRSTAGE... 17528, April 9,2007); Samsung (72 FR 71387, Dec. 17, 2007); FUJITSU (72 FR 71383, Dec. 17, 2007); Daikin...
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Directory of Open Access Journals (Sweden)
Verhasselt Bruno
2008-07-01
Full Text Available Abstract Background Variant translocations t(9;22 occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60–80% of patients in blast crisis (BC. Here, we report on a CML patient in blast crisis presenting with a four-way variant t(9;22 rearrangement involving the EVI1 locus. Methods Dual-colour Fluorescence In Situ Hybridisation was performed to unravel the different cytogenetic aberrations. Expression levels of EVI1 and BCR/ABL1 were investigated using real-time quantitative RT-PCR. Results In this paper we identified a patient with a complex 4-way t(3;9;17;22 which, in addition to BCR/ABL1 gene fusion, also resulted in EVI1 rearrangement and overexpression. Conclusion This report illustrates how a variant t(9;22 translocation can specifically target a second oncogene most likely contributing to the more aggressive phenotype of the disease. Molecular analysis of such variants is thus warranted to understand the phenotypic consequences and to open the way for combined molecular therapies in order to tackle the secondary oncogenic effect which is unresponsive to imatinib treatment.
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Directory of Open Access Journals (Sweden)
Chang Chao-Sung
2012-10-01
Full Text Available Abstract Background Few studies have examined the longitudinal changes in the patterns, selection, and utilization of treatments for chronic myeloid leukemia (CML in routine clinical practice since the introduction of imatinib. Therefore, we investigated the trends in CML therapy, including changes, patterns, and persistence to imatinib therapy among patients with newly diagnosed CML. Methods We conducted a cross-sectional and longitudinal analysis of 11 years of claims data for patients with newly diagnosed CML included in the Taiwan National Health Insurance program. Pharmacy and diagnosis claims for newly diagnosed CML recorded between 1997 and 2007 year were extracted from the database. Annual overall use, new use of CML therapy, and persistence to imatinib therapy were estimated. The Anatomical Therapeutic Chemical codes for CML therapy [i.e., imatinib and conventional therapy: busulfan, hydroxyurea, interferon-α (IFNα, and cytarabine], and the process code for hematopoietic stem cell transplantation were used to categorize treatment patterns. Associations with patients characteristics were analyzed by multivariate logistic regression. Results Overall, the proportion of patients with newly diagnosed CML to all patients with CML increased by approximately 4-fold between 1998 and 2007. There were steady increases in the proportions of all treated patients and those starting therapy from 2003 to 2007. Fewer comorbid conditions and lower severity of CML were associated with treatment initiation. Medication persistence varied according to treatment duration, as 38.7% patients continued imatinib for ≥ 18 months without interruption but only 7.7% continued imatinib for ≥ 5 years. Factors associated with persistence to imatinib therapy were removal of the need for prior authorization for imatinib, and prior use of hydroxyurea and IFNα, whereas having undergone hematopoietic stem cell transplantation led to reduced likelihood
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2012-02-15
...; Samsung Electronics America, Inc. of NJ; Samsung Telecommunications America L.L.C. of TX; Sony Corporation of Japan; Sony Corporation of America of NY; Sony Electronics, Inc. of CA; Sony Ericsson Mobile of... respondents Research In Motion Ltd. of Canada; Research In Motion Corp. of TX; HTC Corporation of Taiwan; HTC...
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2011-04-19
... granted waivers to Electrolux (76 FR 11440 (March 2, 2011)) and Samsung (76 FR 13169 (March 10, 2011... granted to Whirlpool, GE, Samsung and Electrolux, as well as previously to LG, the clothes washer test... make representations about the energy use of its clothes washer products for compliance, marketing, or...
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2011-12-22
..., 2011)) and Samsung (76 FR 13169 (Mar. 10, 2011); 76 FR 50207 (Aug. 12, 2011)). DOE notes that its... was submitted by LG, the waivers granted to Whirlpool, GE, Samsung and Electrolux, as well as... may make representations about the energy use of its clothes washer products for compliance, marketing...
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2014-05-30
dataType ="xsd:double" dictRef="cml:molwt" units...34units:g ">30.0690 </scalar > </property > <property dictRef="cml:monoisotopicwt" title="Monoisotopic weight" > <scalar dataType ="xsd:double" dictRef...34cml:monoisotopicwt" units ="units:g">30.0469502 </scalar > </property > <property dictRef="cml:mp" title="Melting point"> <scalar dataType
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[Experiments with sausage meat on the formation of N epsilon-carboxymethyllysine].
Hartkopf, J; Erbersdobler, H F
1995-07-01
In model experiments the influence of ingredients normally used for sausage production to a meat homogenate on the formation of N epsilon-carboxymethyllysine (CML) was investigated. The formation of CML is obviously more promoted from the reaction of ascorbate with lysine than from that of glucose with lysine. The addition of ascorbate in a practical concentration yielded 35 mg, the addition of glucose only 23 mg compared to 17 mg CML/kg protein in the control sample. The addition of diphosphate in a practical concentration besides glucose significantly increased the CML values from 23 mg to 30 mg CML/kg protein. On the other hand, nitrite did not enhance the formation of CML (21 mg/kg protein) in the sausage when used in concentrations usually applied in meat processing. Generally the values found in the meat products are quite low compared to data in other foods like milk products.
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Estimation of the target stem-cell population size in chronic myeloid leukemogenesis
International Nuclear Information System (INIS)
Radivoyevitch, T.; Ramsey, M.J.; Tucker, J.D.
1999-01-01
Estimation of the number of hematopoietic stem cells capable of causing chronic myeloid leukemia (CML) is relevant to the development of biologically based risk models of radiation-induced CML. Through a comparison of the age structure of CML incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program and the age structure of chromosomal translocations found in healthy subjects, the number of CML target stem cells is estimated for individuals above 20 years of age. The estimation involves three steps. First, CML incidence among adults is fit to an exponentially increasing function of age. Next, assuming a relatively short waiting time distribution between BCR-ABL induction and the appearance of CML, an exponential age function with rate constants fixed to the values found for CML is fitted to the translocation data. Finally, assuming that translocations are equally likely to occur between any two points in the genome, the parameter estimates found in the first two steps are used to estimate the number of target stem cells for CML. The population-averaged estimates of this number are found to be 1.86 x 10 8 for men and 1.21 x 10 8 for women; the 95% confidence intervals of these estimates are (1.34 x 10 8 , 2.50 x 10 8 ) and (0.84 x 10 8 , 1.83 x 10 8 ), respectively. (orig.)
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International Nuclear Information System (INIS)
Askmyr, M; Ågerstam, H; Lilljebjörn, H; Hansen, N; Karlsson, C; Palffy, S von; Landberg, N; Högberg, C; Lassen, C; Rissler, M; Richter, J; Ehinger, M; Järås, M; Fioretos, T
2014-01-01
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CML, whereas additional genetic lesions are needed for progression into CML BC. To generate a humanized CML model, we retrovirally expressed BCR-ABL1 in the cord blood CD34 + cells and transplanted these into NOD-SCID (non-obese diabetic/severe-combined immunodeficient) interleukin-2-receptor γ-deficient mice. In primary mice, BCR-ABL1 expression induced an inflammatory-like state in the bone marrow and spleen, and mast cells were the only myeloid lineage specifically expanded by BCR-ABL1. Upon secondary transplantation, the pronounced inflammatory phenotype was lost and mainly human mast cells and macrophages were found in the bone marrow. Moreover, a striking block at the pre-B-cell stage was observed in primary mice, resulting in an accumulation of pre-B cells. A similar block in B-cell differentiation could be confirmed in primary cells from CML patients. Hence, this humanized mouse model of CML reveals previously unexplored features of CP CML and should be useful for further studies to understand the disease pathogenesis of CML
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Tanabe, Y; Dan, K; Kuriya, S; Nomura, T
1989-10-01
The effects of recombinant human interferon (IFN) alpha-2b and gamma on the bone marrow megakaryocyte progenitors (CFU-Meg) were compared between eight patients in the chronic phase of Ph1-positive chronic myelocytic leukemia (CML) and five hematologically normal patients. CFU-Meg was assayed in plasma clot culture added with phytohemagglutinin-stimulated leukocyte-conditioned medium as a source of colony stimulating activity. The average count of CFU-Meg colonies formed from the bone marrow of CML patients was 5.5 times that of normal controls. Spontaneous CFU-Meg colonies were grown in seven of eight CML patients, but in none of five controls. Colony formation by CFU-Meg in CML as well as normal bone marrow was suppressed by the two preparations of IFN in a dose dependent fashion. Their suppressive influence on colonies from CFU-Meg was comparable between CML and normal bone marrow at lower concentrations, but was less marked for CML than normal bone marrow at higher concentrations. The formation of CFU-Meg colonies from CML bone marrow was more severely suppressed by IFN-gamma than IFN-alpha-2b. Depletion of either T lymphocytes or adherent cells from the CML bone marrow cells diminished the suppressive effects of IFN-gamma, but had no influence on the effects of IFN-alpha-2b.
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Scribano, Daniela; Damico, Rosanna; Ambrosi, Cecilia; Superti, Fabiana; Marazzato, Massimiliano; Conte, Maria Pia; Longhi, Catia; Palamara, Anna Teresa; Zagaglia, Carlo; Nicoletti, Mauro
2016-12-01
Shigella flexneri is an intracellular pathogen that deploys an arsenal of virulence factors promoting host cell invasion, intracellular multiplication and intra- and inter-cellular dissemination. We have previously reported that the interaction between apyrase (PhoN2), a periplasmic ATP-diphosphohydrolase, and the C-terminal domain of the outer membrane (OM) protein OmpA is likely required for proper IcsA exposition at the old bacterial pole and thus for full virulence expression of Shigella flexneri (Scribano et al., 2014). OmpA, that is the major OM protein of Gram-negative bacteria, is a multifaceted protein that plays many different roles both in the OM structural integrity and in the virulence of several pathogens. Here, by using yeast two-hybrid technology and by constructing an in silico 3D model of OmpA from S. flexneri 5a strain M90T, we observed that the OmpA residues 188 EVQ 190 are likely essential for PhoN2-OmpA interaction. The 188 EVQ 190 amino acids are located within a flexible region of the OmpA protein that could represent a scaffold for protein-protein interaction.
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Directory of Open Access Journals (Sweden)
Muhammad Rauzan
Full Text Available Chronic myeloid leukemia (CML treatment has been improved by tyrosine kinase inhibitors (TKIs such as imatinib mesylate (IM but various factors can cause TKI resistance in patients with CML. One factor which contributes to TKI resistance is a germline intronic deletion polymorphism in the BCL2-like 11 (BIM gene which impairs the expression of pro-apoptotic splice isoforms of BIM. SB939 (pracinostat is a hydroxamic acid based HDAC inhibitor with favorable pharmacokinetic, physicochemical and pharmaceutical properties, and we investigated if this drug could overcome BIM deletion polymorphism-induced TKI resistance. We found that SB939 corrects BIM pre-mRNA splicing in CML cells with the BIM deletion polymorphism, and induces apoptotic cell death in CML cell lines and primary cells with the BIM deletion polymorphism. More importantly, SB939 both decreases the viability of CML cell lines and primary CML progenitors with the BIM deletion and restores TKI-sensitivity. Our results demonstrate that SB939 overcomes BIM deletion polymorphism-induced TKI resistance, and suggest that SB939 may be useful in treating CML patients with BIM deletion-associated TKI resistance.
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Chronic Myeloid Leukemia In a Pregnant Woman: A Case Report
Directory of Open Access Journals (Sweden)
Aytekin Tokmak
2015-12-01
Full Text Available Chronic myeloid leukemia (CML is a rare disease in pregnancy. Our aim is to present a 37 weeks of pregnant woman with chronic myelogenous leukemia. A 27 Years in multigravi (gravida 5, parity: 4, at 37 weeks gestation was admitted with the diagnosis of painful pregnancy and CML. Physical examination findings were normal, complete blood count and peripheral blood smear results were consistent with CML. The patient was diagnosed CML in the 30th week of pregnancy and were treated with hydroxyurea and interferon. Treatment depends on the mother and the fetus did not develop any side effects. Our patient with CML is interesting due to lack of perinatal effects and take the diagnosis at an early age. CML diagnosed during pregnancy requires a multidisciplinary approach and hydroxyurea and interferon treatment on the mother and fetus are at low risk of inducing adverse effects. [Cukurova Med J 2015; 40(4.000: 811-813
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Okamura, Keisuke; Okuda, Tetsu; Shirai, Kazuyuki; Urata, Hidenori
2018-01-01
The aim of the present study was to establish a convenient clinically applicable assay method for chymase-dependent angiotensin II forming activity of circulating mononuclear leukocytes (CML), which was potentially a marker of tissue chymase activity. Using this method, association between CML chymase activity and clinical parameters was determined. Cardiovascular outpatients (n = 170) without taking antihypertensive medication were recruited. An ELISA for chymase-dependent angiotensin II-forming activity in CML was established using Nma /Dnp-modified angiotensin I. Logistic regression analysis revealed that age and male gender were significant independent determinants of the increased CML chymase activity. After adjustment by age and gender, the CML chymase activity was positively correlated with systolic blood pressure, pulse rate, and the brain natriuretic peptide level. The relation between blood pressure and CML chymase activity suggests that it might reflect that increased tissue chymase activity contributes to systemic high blood pressure and heart rate because plasma chymase is inactive due to inhibitory plasma inhibitors.
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Circulating endothelial cells are increased in chronic myeloid leukemia blast crisis
Directory of Open Access Journals (Sweden)
C.R.T. Godoy
2015-06-01
Full Text Available We measured circulating endothelial precursor cells (EPCs, activated circulating endothelial cells (aCECs, and mature circulating endothelial cells (mCECs using four-color multiparametric flow cytometry in the peripheral blood of 84 chronic myeloid leukemia (CML patients and 65 healthy controls; and vascular endothelial growth factor (VEGF by quantitative real-time PCR in 50 CML patients and 32 healthy controls. Because of an increase in mCECs, the median percentage of CECs in CML blast crisis (0.0146% was significantly higher than in healthy subjects (0.0059%, P0.05. In addition, VEGF gene expression was significantly higher in all phases of CML: 0.245 in blast crisis, 0.320 in the active phase, and 0.330 in chronic phase patients than it was in healthy subjects (0.145. In conclusion, CML in blast crisis had increased levels of CECs and VEGF gene expression, which may serve as markers of disease progression and may become targets for the management of CML.
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Robust zero resistance in a superconducting high-entropy alloy at pressures up to 190 GPa
Guo, Jing; Wang, Honghong; von Rohr, Fabian; Wang, Zhe; Cai, Shu; Zhou, Yazhou; Yang, Ke; Li, Aiguo; Jiang, Sheng; Wu, Qi; Cava, Robert J.; Sun, Liling
2017-12-01
We report the observation of extraordinarily robust zero-resistance superconductivity in the pressurized (TaNb)0.67(HfZrTi)0.33 high-entropy alloy--a material with a body-centered-cubic crystal structure made from five randomly distributed transition-metal elements. The transition to superconductivity (TC) increases from an initial temperature of 7.7 K at ambient pressure to 10 K at ˜60 GPa, and then slowly decreases to 9 K by 190.6 GPa, a pressure that falls within that of the outer core of the earth. We infer that the continuous existence of the zero-resistance superconductivity from 1 atm up to such a high pressure requires a special combination of electronic and mechanical characteristics. This high-entropy alloy superconductor thus may have a bright future for applications under extreme conditions, and also poses a challenge for understanding the underlying quantum physics.
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2012-02-01
..., 2011)); (76 FR 79666 (Dec. 22, 2011)) and Samsung (76 FR 13169 (Mar. 10, 2011)); 76 FR 50207 (Aug. 12... consideration of all the material that was submitted by LG, the waivers granted to Whirlpool, GE, Samsung and... clothes washer products for compliance, marketing, or other purposes only to the extent that such products...
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Excitation of the high-spin isomers 180m Hf, 190m Os and 204m Pb in (γ, γ') reactions
International Nuclear Information System (INIS)
Balabanov, N.P.; Belov, A.G.; Gangrskij, Yu.P.; Kondev, F.G.; Tonchev, A.P.
1993-01-01
Excitation of isomeric states of 180 Hf (J m π = 8 - ), 190 Os (J m π = 10 - ) and 204 Pb (J m π = 9 - ) is studied for (γ, γ') reactions. The cross sections and isomeric ratios are measured using activation technique in the energy region from 6 up to 15 MeV. Experimental results were compared with statistical theory predictions. A relative contribution of different γ-ray multipolarities into the process of the population of isomeric states excited in the photoabsorption reaction and γ-cascade is investigated. (author). 32 refs.; 4 figs.; 2 tabs
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Wang, Zhiqiong; Zen, Wen; Meng, Fankai; Xin, Xing; Luo, Li; Sun, Hanying; Zhou, Jianfeng; Huang, Lifang
2015-01-01
Chronic myeloid leukemia (CML) is most frequently observed in middle-aged individuals. In most patients, normal marrow cells are replaced by cells with an abnormal G-group chromosome, the Philadelphia (Ph) chromosome. The Ph chromosome that is characterized by the translocation (9;22) (q34;q11) is noted in 90-95% of patients diagnosed with CML. Studies have also shown that CML can be associated with various other cytogenetic abnormalities, with 5-10% of these cases showing complex translocation involving another chromosome in addition to the Ph chromosome. Here, we report the case of a Ph(+) CML patient with an inserted karyotype who presented clinically in the chronic phase but with atypical features. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML.
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Huang, Jixian; Lu, Ziyuan; Xiao, Yajuan; He, Bolin; Pan, Chengyun; Zhou, Xuan; Xu, Na; Liu, Xiaoli
2018-02-05
BACKGROUND A hypoxic microenvironment is associated with resistance to tyrosine kinase inhibitors (TKIs) and a poor prognosis in chronic myeloid leukemia (CML). The E3 ubiquitin ligase Siah2 plays a vital role in the regulation of hypoxia response, as well as in leukemogenesis. However, the role of Siah2 in CML resistance is unclear, and it is unknown whether vitaminK3 (a Siah2 inhibitor) can improve the chemo-sensitivity of CML cells in a hypoxic microenvironment. MATERIAL AND METHODS The expression of Siah2 was detected in CML patients (CML-CP and CML-BC), K562 cells, and K562-imatinib-resistant cells (K562-R cells). We measured the expression of PHD3, HIF-1α, and VEGF in both cell lines under normoxia and hypoxic conditions, and the degree of leukemic sensitivity to imatinib and VitaminK3 were evaluated. RESULTS Siah2 was overexpressed in CML-BC patients (n=9) as compared to CML-CP patients (n=13). Similarly, K562-imatinib-resistant cells (K562-R cells) showed a significantly higher expression of Siah2 as compared to K562 cells in a hypoxic microenvironment. Compared to normoxia, under hypoxic conditions, both cell lines had lower PHD3, higher HIF-1α, and higher VEGF expression. Additionally, Vitamin K3 (an inhibitor of Siah2) reversed these changes and promoted a higher degree of leukemic sensitivity to imatinib. CONCLUSIONS Our findings indicate that the Siah2-PHD3- HIF-1α-VEGF axis is an important hypoxic signaling pathway in a leukemic microenvironment. An inhibitor of Siah2, combined with TKIs, might be a promising therapy for relapsing and refractory CML patients.
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Zhou, H; Mak, P Y; Mu, H; Mak, D H; Zeng, Z; Cortes, J; Liu, Q; Andreeff, M; Carter, B Z
2017-01-01
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation, remain formidable challenges for chronic myeloid leukemia (CML). We observed overexpression of β-catenin in BC-CML stem/progenitor cells, particularly in granulocyte–macrophage progenitors, and highest among a novel CD34+CD38+CD123hiTim-3hi subset as determined by CyTOF analysis. Co-culture with mesenchymal stromal cells (MSCs) induced the expression of β-catenin and its target CD44 in CML cells. A novel Wnt/β-catenin signaling modulator, C82, and nilotinib synergistically killed KBM5T315I and TKI-resistant primary BC-CML cells with or without BCR–ABL kinase mutations even under leukemia/MSC co-culture conditions. Silencing of β-catenin by short interfering RNA restored sensitivity of primary BCR–ABLT315I/E255V BC-CML cells to nilotinib. Combining the C82 pro-drug, PRI-724, with nilotinib significantly prolonged the survival of NOD/SCID/IL2Rγ null mice injected with primary BCR–ABLT315I/E255V BC-CML cells. The combined treatment selectively targeted CML progenitors and inhibited CD44, c-Myc, survivin, p-CRKL and p-STAT5 expression. In addition, pretreating primary BC-CML cells with C82, or the combination, but not with nilotinib alone, significantly impaired their engraftment potential in NOD/SCID/IL2Rγ-null-3/GM/SF mice and significantly prolonged survival. Our data suggest potential benefit of concomitant β-catenin and Bcr–Abl inhibition to prevent or overcome Bcr–Abl kinase-dependent or -independent TKI resistance in BC-CML. PMID:28321124
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Zhou, H; Mak, P Y; Mu, H; Mak, D H; Zeng, Z; Cortes, J; Liu, Q; Andreeff, M; Carter, B Z
2017-10-01
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation, remain formidable challenges for chronic myeloid leukemia (CML). We observed overexpression of β-catenin in BC-CML stem/progenitor cells, particularly in granulocyte-macrophage progenitors, and highest among a novel CD34 + CD38 + CD123 hi Tim-3 hi subset as determined by CyTOF analysis. Co-culture with mesenchymal stromal cells (MSCs) induced the expression of β-catenin and its target CD44 in CML cells. A novel Wnt/β-catenin signaling modulator, C82, and nilotinib synergistically killed KBM5 T315I and TKI-resistant primary BC-CML cells with or without BCR-ABL kinase mutations even under leukemia/MSC co-culture conditions. Silencing of β-catenin by short interfering RNA restored sensitivity of primary BCR-ABL T315I/E255V BC-CML cells to nilotinib. Combining the C82 pro-drug, PRI-724, with nilotinib significantly prolonged the survival of NOD/SCID/IL2Rγ null mice injected with primary BCR-ABL T315I/E255V BC-CML cells. The combined treatment selectively targeted CML progenitors and inhibited CD44, c-Myc, survivin, p-CRKL and p-STAT5 expression. In addition, pretreating primary BC-CML cells with C82, or the combination, but not with nilotinib alone, significantly impaired their engraftment potential in NOD/SCID/IL2Rγ-null-3/GM/SF mice and significantly prolonged survival. Our data suggest potential benefit of concomitant β-catenin and Bcr-Abl inhibition to prevent or overcome Bcr-Abl kinase-dependent or -independent TKI resistance in BC-CML.
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Clinical medical librarian: the last unicorn?
Demas, J M; Ludwig, L T
1991-01-01
In the information age of the 1990s, the clinical medical librarian (CML) concept, like many other personalized library services, is often criticized as being too labor-intensive and expensive; others praise its advantages. To determine the attitudes of medical school library directors and clinical department heads toward implementation and feasibility of a CML program, forty randomly selected medical schools were surveyed. A double-blind procedure was used to sample department heads in internal medicine, pediatrics, and surgery, as well as health sciences library directors identified by the Association of Academic Health Sciences Library Directors (AAHSLD) annual statistics. The survey instrument was designed to measure responses to the following attitudinal variables: acceptance and nonacceptance of a CML program; importance to patient care, education, and research; influence on information-seeking patterns of health care professionals; ethical issues; CML extension services; and costs. Seventy-nine usable questionnaires out of a total of 120 (66%) were obtained from clinical medical personnel, and 30 usable questionnaires out of a total of 40 (75%) were obtained from medical school library directors. Survey results indicated significant differences between clinical medical personnel and library personnel regarding attitudes toward CML influence on information-seeking patterns, ethics, alternative CML services, and costs. Survey results also indicated a continuing strong support for CML programs in the medical school setting; however, differences of opinion existed toward defining the role of the CML and determining responsibility for funding.
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Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients.
Zahran, Asmaa M; Badrawy, Hosny; Ibrahim, Abeer
2014-08-01
Chronic myeloid leukemia (CML) is a clonal disease, characterized by a reciprocal t(9, 22) that results in a chimeric BCR/ABL fusion gene. Regulatory T cells (Tregs) constitute the main cell population that enables cancer cells to evade immune surveillance. The purpose of our study was to investigate the level of Tregs in newly diagnosed CML patients and to correlate it with the patients' clinical, laboratory and molecular data. We also aimed to assess the effect of treatment using tyrosine kinase inhibitor (TKI) on Treg levels. Tregs were characterized and quantified by flow cytometry in 63 newly diagnosed CML patients and 40 healthy controls. TKI was used in 45 patients with chronic phase CML, and the response to therapy was correlated with baseline Treg levels. The percentages of Tregs were significantly increased in CML patients compared to the controls. Treg numbers were significantly lower in patients with chronic phase CML versus the accelerated and blast phases, and were significantly lower in patients with complete molecular remission (CMR) compared to those patients without CMR. Tregs may play a role in the maintenance of CML. Moreover, the decrease of their levels in patients with CMR suggests that Tregs might have a clinical value in evaluating the effects of therapy.
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International Nuclear Information System (INIS)
Sun, Yang; Zhang, Jing-ye; Guidry, Mike
2001-01-01
Interplay of collective and single-particle degrees of freedom is a common phenomenon in strongly correlated many-body systems. Despite many successful efforts in the study of superdeformed nuclei, there is still unexplored physics that can be best understood only through the nuclear magnetic properties. We point out that study of the gyromagnetic factor (g factor) may open a unique opportunity for understanding superdeformed structure. Our calculations suggest that investigation of the g-factor dependence on spin and particle number can provide important information on single-particle structure and its interplay with collective motion in the superdeformed mass-190 nuclei. Modern experimental techniques combined with the new generation of sensitive detectors should be capable of testing our predictions
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Caballero ontanaya, L; Garcia borge, M J; Malbrunot, S
2002-01-01
This proposal is aimed at the study of the $\\beta$- decay of the neutron-deficient $^{188,190,192}$Pb nuclei. The main motivation of the proposed experiment is to determine the Gamow-Teller strength distribution in the daughter nuclei using the Total Absorption Spectrometer "Lucrecia". Recent theoretical results show that from this measurement the shapes of the ground states of the decaying Pb nuclei can be inferred. This study offers an independent way to study the phenomenon of shape co-existence in a region of particular interest.
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Targeting of the BLT2 in chronic myeloid leukemia inhibits leukemia stem/progenitor cell function
Energy Technology Data Exchange (ETDEWEB)
Xiao, Meifang; Ai, Hongmei; Li, Tao [Department of Laboratory Medicine, JingZhou Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Jingzhou (China); Rajoria, Pasupati; Shahu, Prakash [Department of Clinical Medicine, Medical School of Yangtze University, Jingzhou (China); Li, Xiansong, E-mail: lixiansongjz@hotmail.com [Department of Neurosurgery, JingZhou Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Jingzhou (China)
2016-04-15
Imatinib, a tyrosine kinase inhibitor (TKI) has significantly improved clinical outcome for chronic myeloid leukemia (CML) patients. However, patients develop resistance when the disease progresses to the blast phase (BP) and the mechanisms are not well understood. Here we show that BCR-ABL activates BLT2 in hematopoietic stem/progenitor cells to promote leukemogenesis and this involves the p53 signaling pathway. Compared to normal bone marrow (NBM), the mRNA and protein levels of BLT2 are significantly increased in BP-CML CD34{sup +} stem/progenitor cells. This is correlated with increasing BCR-ABL expression. In contrast, knockdown of BCR-ABL or inhibition of its tyrosine kinase activity decreases Blt2 protein level. BLT2 inhibition induces apoptosis, inhibits proliferation, colony formation and self-renewal capacity of CD34{sup +} cells from TKI-resistant BP-CML patients. Importantly, the inhibitory effects of BCR-ABL TKI on CML stem/progenitor cells are further enhanced upon combination with BLT2 inhibition. We further show that BLT2 activation selectively suppresses p53 but not Wnt or BMP-mediated luciferase activity and transcription. Our results demonstrate that BLT2 is a novel pathway activated by BCR-ABL and critically involved in the resistance of BP-CML CD34{sup +} stem/progenitors to TKIs treatment. Our findings suggest that BLT2 and p53 can serve as therapeutic targets for CML treatment. - Highlights: • BCR-ABL regulates BLT2 expression to promote leukemogenesis. • BLT2 is essential to maintain CML cell function. • Activation of BLT2 suppresses p53 signaling pathway in CML cells. • Inhibition of BLT2 and BCR-ABL synergize in eliminating CML CD34{sup +} stem/progenitors.
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Superdeformation in the A = 190 region. The lead nuclei
Energy Technology Data Exchange (ETDEWEB)
Henry, E A; Becker, J A; Brinkman, M J; Kuhnert, A; Stoyer, M A; Wang, T F; Yates, S W [Lawrence Livermore National Lab., CA (United States); Azaiez, F A; Beausang, C W; Burde, J; Deleplanque, M A; Diamond, R M; Draper, J E; Kelly, W H; Korton, W; Macchiavelli, A O; Oliveira, J; Rubel, E; Stephens, F S [Lawrence Berkeley Lab., CA (United States); Cizewski, J A [Rutgers--the State Univ., New Brunswick, NJ (United States)
1992-08-01
Superdeformed (SD) bands have been identified in the four even-even lead nuclei {sup 192}Pb, {sup 194}Pb, {sup 196}Pb, and {sup 198}Pb. The discovery of SD bands in these nuclei extended the region of superdeformation in the A = 190 region to Z = 82, and to neutron numbers up to N = 116. All of the SD bands in these nuclei are observed with transition energies ranging from about 250 keV to about 600 keV, with the lowest energy SD band transition for the entire region of 169 keV in {sup 194}Pb. The spins deduced for the lowest levels in the SD bands are 6, 8, and 12 for {sup 192,194,196,198}Pb, respectively. The dynamic moments of inertia of {sup 192}Pb and {sup 194}Pb are similar to each other, and to those of many other SD bands in this mass region. The dynamic moments of inertia of {sup 1}`9{sup 6}Pb and {sup 198}Pb are somewhat lower than those of {sup 192,194}Pb at a given frequency. The experimental lifetimes in {sup 194}Pb and the deduced transition quadrupole moments (Qt {approx} 20 eb) are equal to those of other nuclei in the region within errors. While SD bands have been observed in the odd-neutron Hg and Tl nuclei, SD bands have not been reported for the odd-neutron Pb nuclei. In this contribution we discuss briefly three topics on superdeformation in the lead nuclei. First, we have recent experimental data on {sup 196}Pb that extends our knowledge of the SD band in that nucleus. Next we review briefly the population of low-lying yrast levels from the decay of the SD bands in {sup 192,194,196}Pb. Finally, we summarize our efforts to identify superdeformation in the odd-A Pb nuclei. All of the experiments described here were performed using the HERA spectrometer at the 88-Inch Cyclotron facility located at Lawrence Berkeley Laboratory. (author) 9 refs., 4 figs.
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Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells.
Wang, Yalin; Jiang, Yan; Ma, Ning; Sang, Bailu; Hu, Xiaolin; Cong, Xiaofeng; Liu, Ziling
2015-09-01
Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by dysregulated growth and proliferation of hematopoietic stem/progenitor cells in bone marrow and excessive expansion of hematopoietic compartments in peripheral blood. Expression deletion of Hiwi, a human Piwi homolog, has been reported to be implicated in leukemogenesis. We here explored Hiwi's role in CML pathogenesis by determining how and whether its forced overexpression could affect CML cell growth and migration. The present results showed that lentivirus-mediated overexpression of Hiwi significantly suppressed cell proliferation and induced obvious apoptosis in K562 cells, a CML line cell line. Tumors in BALB/c nude mice generated by the K562 cells expressing Hiwi were much smaller than those formed by the control cells. Like in vitro, Hiwi upregulation induced cell apoptosis in the tumor tissues in vivo. Additionally, Hiwi elevation suppressed K562 cell migration and inhibited the activity and expression of matrix metalloproteinase-2 and -9. In summary, our study demonstrates that Hiwi overexpression inhibits CML cell growth and migration, providing insights into its role in CML pathogenesis.
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International Nuclear Information System (INIS)
Wajid, N.; Ali, M.; Javed, S.; Ali, F.; Anwar, S. S.
2016-01-01
Objective: To determine the effects of blood from CML patients on human umbilical cord derived Wharton's jelly mesenchymal stem cells (WJMSCs) for evaluation of their therapeutic potential. Study Design: An experimental study. Place and Duration of Study: Centre for Research in Molecular Medicine, University of Lahore, from September 2013 to December 2014. Methodology: Possible behavior of WJMSCs in CML patients was assessed by culturing these cells in their plasma. WJMSCs at passage 3 were cultured in plasma isolated from 9 CML patients as well as 9 normal subjects. Effects on cell viability, proliferation, LDH release, paracrine factors (p38 and p53) and oxidative stress were evaluated. Result: WJMSCs cultured in plasma of CML patients showed decreased viability, slow proliferation, high LDH release, high expression of p38 and p53 and a high oxidative stress compared to normal subjects. Conclusion: Stressed environment of CML patients' blood/plasma induced injury to WJMSCs as well as reduced their viability. Effectiveness of these cells for therapeutics of CML is, therefore, likely to be reduced. (author)
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Patel, Ami B; Wilds, Brandon W; Deininger, Michael W
2017-07-01
With the discovery of imatinib mesylate nearly 20 years ago, tyrosine kinase inhibitors (TKIs) were found to be effective in chronic myeloid leukemia (CML). TKI therapy has since revolutionized the treatment of CML and has served as a paradigm of success for targeted drug therapy in cancer. Several new TKIs for CML have been approved over the last two decades that exhibit improved potency over imatinib and have different off-target profiles, providing options for individualized therapy selection. Areas covered: Current management of chronic phase CML, including guidance on the sequential use of imatinib and newer-generation TKIs and evolving treatment strategies such as TKI discontinuation. Relevant literature was identified by searching biomedical databases (i.e. PubMed) for primary research material. Expert commentary: Although survival outcomes have drastically improved for CML patients, treatment for CML has grown more complex with the introduction of next-generation TKIs and the advent of treatment-free remissions (TFR). Goals of therapy have shifted accordingly, with increased focus on improving quality of life, managing patient expectations and optimizing patient adherence.
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Jiao, Ye; He, Jialiang; Li, Fengli; Tao, Guanjun; Zhang, Shuang; Zhang, Shikang; Qin, Fang; Zeng, Maomao; Chen, Jie
2017-10-01
The levels of N ε -(carboxymethyl)lysine (CML) and N ε -(carboxyethyl)lysine (CEL) in 99 tea samples from 14 geographic regions, including 44 green, 7 oolong, 41 black, and 7 dark teas were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The CML and CEL contents varied from 11.0 to 1701μg/g tea and 4.6 to 133μg/g tea, respectively. Dark tea presented the highest levels of CML and CEL, whereas green and oolong teas presented the lowest levels. Five kinds of catechins in the tea were also analyzed, and spearman's correlation coefficients showed that all the catechins negatively correlated with CML and CEL. The results suggested that withering, fermentation and pile fermentation may facilitate the formation of CML and CEL. Catechins might inhibit the formation of CML and CEL, but their inhibitory effects may be affected by tea processing. The results of this study are useful for the production of healthier tea. Copyright © 2017. Published by Elsevier Ltd.
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Ali, Mohamed A M
2016-08-01
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, characterized by the unrestrained expansion of pluripotent hematopoietic stem cells. CML was the first malignancy in which a unique chromosomal abnormality was identified and a pathophysiologic association was suggested. The hallmark of CML is a reciprocal chromosomal translocation between the long arms of chromosomes 9 and 22, t(9; 22)(q34; q11), creating a derivative 9q+ and a shortened 22q-. The latter, known as the Philadelphia (Ph) chromosome, harbors the breakpoint cluster region-abelson (BCR-ABL) fusion gene, encoding the constitutively active BCR-ABL tyrosine kinase that is necessary and sufficient for initiating CML. The successful implementation of tyrosine kinase inhibitors (TKIs) for the treatment of CML remains a flagship for molecularly targeted therapy in cancer. TKIs have changed the clinical course of CML; however, some patients nonetheless demonstrate primary or secondary resistance to such therapy and require an alternative therapeutic strategy. Therefore, the assessment of early response to treatment with TKIs has become an important tool in the clinical monitoring of CML patients. Although mutations in the BCR-ABL have proven to be the most prominent mechanism of resistance to TKIs, other mechanisms-either rendering the leukemic cells still dependent on BCR-ABL activity or supporting oncogenic properties of the leukemic cells independent of BCR-ABL signaling-have been identified. This article provides an overview of the current understanding of CML pathogenesis; recommendations for diagnostic tools, treatment strategies, and management guidelines; and highlights the BCR-ABL-dependent and -independent mechanisms that contribute to the development of resistance to TKIs.
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Sun, Yingying; Hua, Xiuyi; Ge, Rui; Guo, Aitong; Guo, Zhiyong; Dong, Deming; Sun, Wentian
2013-08-01
Centrifugal mother liquid (CML) is one of the main sources of wastewater produced during the production of polyvinyl chloride in chlor-alkali industry. CML is a typical poorly biodegradable organic wastewater, containing many kinds of refractory pollutants. Specifically, it contains dissolved refractory polymers, especially polyvinyl alcohol (PVA), which can pass though the biotreatment processes and clog the membranes used for further treatment. In this study, to ensure the CML applicable to biotreatment and membrane treatment, a novel efficient and mild technique, air-Fenton treatment, was employed as a pretreatment technique to improve biodegradability of the CML and to break down the polymers in the CML. Firstly, the technique was optimized for the CML treatment by optimizing the main parameters, including the dosage of ferrous sulfate, initial pH of the wastewater, [H2O2]/[Fe(2+)], aeration rate, reaction time, and temperature, based on removal efficiency of COD and PVA from the CML. Then, the optimized technique was tested and evaluated. The results indicated that under the optimized conditions, the air-Fenton treatment could remove 66, 98, and 55 % of the COD, PVA, and TOC, respectively, from the CML. After the treatment, biodegradability of the wastewater increased significantly (BOD/COD increased from 0.31 to 0.68), and almost all of the PVA polymers were removed or broken down. Meanwhile, concentration of the remaining iron ions, which were added during the treatment, was also quite low (only 2.9 mg/L). Furthermore, most of the suspended materials and ammonia nitrogen, and some of the phosphorus in the wastewater were removed simultaneously.
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DEFF Research Database (Denmark)
Järås, Marcus; Johnels, Petra; Hansen, Nils Gunder
2010-01-01
Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML...... will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression profiling to identify IL-1 receptor accessory protein (IL1RAP) as up-regulated in CML CD34(+) cells and also in cord blood CD34(+) cells as a consequence of retroviral BCR/ABL1 expression. To test...
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International Nuclear Information System (INIS)
Tanaka, Kimio; Takechi, Miho; Shigeta, Chiharu; Sakatani, Keiko; Oguma, Nobuo; Kamada, Nanao; Takimoto, Yasuo; Kuramoto, Atsushi
1989-01-01
This study compared findings of chronic myelocytic leukemia (CML) in A-bomb survivors (n=8) developing CML within 10 years after the bombing and in non-exposed CML patients (n=14). Both Ph 1 chromosomes and bcr rearrangement were observed in all patients in both exposed and non-exposed groups. There was no significant difference in distribution sites of bcr rearrangement between the groups. These results suggest that bcr-abl chimera mRNA and chimera protein associated with Ph 1 chromosomes have an important role in the development of CML among A-bomb survivors, as well as among non-exposed patients. (N.K.)
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Directory of Open Access Journals (Sweden)
Thiago Cezar Fujita
2010-09-01
Full Text Available Chronic myeloid leukemia (CML is a malignant myeloproliferative disorder that originates from a pluripotent stem cell characterized by abnormal release of the expanded, malignant stem cell clone from the bone marrow into the bloodstream. The vast majority of patients with CML present Bcr-Abl transcripts. Lactate dehydrogenase (LDH is considered a biochemical marker common for tumor growth, anaerobic glycolysis and has been considered a poor prognostic factor for acute myeloid leukemia. Therefore, this study aimed to evaluate the concentration of LDH in plasma and the detection of the Bcr-Abl transcripts in patients with CML and healthy donors. We analyzed 22 patients demonstrably diagnosed with CML and 56 healthy donors. LDH concentration in plasma was higher in patients with CML. All patients with CML in this study were under treatment, but even so four patients had the Bcr-Abl (b3a2 transcript in peripheral blood. Two out of the four patients with b3a2 showed higher LDH (486 U L-1 and 589 U L-1. Thus, although the study was conducted with small numbers of samples, it is possible to suggest therapy alteration for two patients who presented transcript b3a2 in the peripheral blood samples and whose LDH concentration was high, in order to improve the disease.Chronic myeloid leukemia (CML is a malignant myeloproliferative disorder that originates from a pluripotent stem cell characterized by abnormal release of the expanded, malignant stem cell clone from the bone marrow into the bloodstream. The vast majority of patients with CML present Bcr-Abl transcripts. Lactate dehydrogenase (LDH is considered a biochemical marker common for tumor growth, anaerobic glycolysis and has been considered a poor prognostic factor for acute myeloid leukemia. Therefore, this study aimed to evaluate the concentration of LDH in plasma and the detection of the Bcr-Abl transcripts in patients with CML and healthy donors. We analyzed 22 patients demonstrably diagnosed
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Changing trends of chronic myeloid leukemia in greater Mumbai, India over a period of 30 years
Dikshit, Rajesh P.; Nagrani, Rajini; Yeole, Balkrishna; Koyande, Shravani; Banawali, Shripad
2011-01-01
Background: Little is known about burden of chronic myeloid leukemia (CML) in India. There is a recent interest to observe incidence and mortality because of advent of new diagnostic and treatment policies for CML. Materials and Methods: We extracted data from the oldest population-based cancer registry of Mumbai for 30 years period from 1976−2005 to observe incidence and mortality rates of CML. We classified the data into four age groups 0–14, 15–29, 30–54 and 55–74 to observe incidence rates in the respective age groups. Results: The age specific rates were highest for the age group of 55–74 years. No significant change in trends of CML was observed for 30 years period. However, there was a significant reduction in incidence rate for recent 15-years period (Estimated average annual percentage change=-3.9). No significant reduction in mortality rate was observed till 2005. Conclusion: The study demonstrates that age-specific rates for CML are highest in age group of 55-74 years, although they are lower compared to western populations. Significant reduction in incidence of CML in recent periods might be because of reduced misclassification of leukemias. The data of CML has to be observed for another decade to witness reduction in mortality because of changes in treatment management. PMID:22174498
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Directory of Open Access Journals (Sweden)
Cesarina Giallongo
Full Text Available It is well known that mesenchymal stem cells (MSC have a role in promotion of tumor growth, survival and drug-resistance in chronic myeloid leukemia (CML. Recent reports indicated that a subpopulation of myeloid cells, defined as granulocyte-like myeloid-derived suppressor cells (G-MDSC is increased in these patients. So far, the role of MSC in MDSC expansion and activation into the BM microenvironment remains unexplored. To address this question, here we use a specific experimental model in vitro, co-culturing MSC with peripheral blood mononucleated cells (PBMC from normal individuals, in order to generate MSC-educated G-MDSC. Although MSC of healthy donors (HD and CML patients were able to generate the same amount of MDSC, only CML-MSC-educated G-MDSC exhibited suppressive ability on autologous T lymphocytes. In addition, compared with HD-MSC, CML-MSC over-expressed some immunomodulatory factors including TGFβ, IL6 and IL10, that could be involved in MDSC activation. CML-MSC-educated G-MDSC expressed higher levels of ARG1, TNFα, IL1β, COX2 and IL6 than G-MDSC isolated from co-culture with HD-MSC. Our data provide evidence that CML-MSC may play a critical role in tumor microenvironment by orchestrating G-MDSC activation and regulating T lymphocytes-mediated leukemia surveillance, thus contributing to CML immune escape.
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Giallongo, Cesarina; Romano, Alessandra; Parrinello, Nunziatina Laura; La Cava, Piera; Brundo, Maria Violetta; Bramanti, Vincenzo; Stagno, Fabio; Vigneri, Paolo; Chiarenza, Annalisa; Palumbo, Giuseppe Alberto; Tibullo, Daniele; Di Raimondo, Francesco
2016-01-01
It is well known that mesenchymal stem cells (MSC) have a role in promotion of tumor growth, survival and drug-resistance in chronic myeloid leukemia (CML). Recent reports indicated that a subpopulation of myeloid cells, defined as granulocyte-like myeloid-derived suppressor cells (G-MDSC) is increased in these patients. So far, the role of MSC in MDSC expansion and activation into the BM microenvironment remains unexplored. To address this question, here we use a specific experimental model in vitro, co-culturing MSC with peripheral blood mononucleated cells (PBMC) from normal individuals, in order to generate MSC-educated G-MDSC. Although MSC of healthy donors (HD) and CML patients were able to generate the same amount of MDSC, only CML-MSC-educated G-MDSC exhibited suppressive ability on autologous T lymphocytes. In addition, compared with HD-MSC, CML-MSC over-expressed some immunomodulatory factors including TGFβ, IL6 and IL10, that could be involved in MDSC activation. CML-MSC-educated G-MDSC expressed higher levels of ARG1, TNFα, IL1β, COX2 and IL6 than G-MDSC isolated from co-culture with HD-MSC. Our data provide evidence that CML-MSC may play a critical role in tumor microenvironment by orchestrating G-MDSC activation and regulating T lymphocytes-mediated leukemia surveillance, thus contributing to CML immune escape.
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International Nuclear Information System (INIS)
Uma, V.S.; Goel, Alpana; Yadav, Archana; Jain, A.K.
2016-01-01
The band-head spin (I 0 ) of superdeformed (SD) rotational bands in A ∼ 190 mass region is predicted using the variable moment of inertia (VMI) model for 66 SD rotational bands. The superdeformed rotational bands exhibited considerably good rotational property and rigid behaviour. The transition energies were dependent on the prescribed band-head spins. The ratio of transition energies over spin Eγ/ 2 I (RTEOS) vs. angular momentum (I) have confirmed the rigid behaviour, provided the band-head spin value is assigned correctly. There is a good agreement between the calculated and the observed transition energies. This method gives a very comprehensive interpretation for spin assignment of SD rotational bands which could help in designing future experiments for SD bands. (author)
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International Nuclear Information System (INIS)
Zhang, Zijian; Kakitani, Shunsuke; Ninomiya, Kazuhiko
2013-01-01
Radioactivities of Sr-90 in air-dust filters collected in Hitachi, Kawasaki and Toyonaka were determined using solid state extraction method and low background beta-ray counting system. In Hitachi, though the Sr-90 activity concentration was decreased with time, the activity rates of Sr-90/Cs-137 kept about 10"-"3 order. This fact suggests that Sr-90 transportation behavior in the atmosphere is similar to that of Cs-137 during the time of sample collection. (author)
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2006-10-31
VHS video, 90 min., (Arlington: Public Broadcasting Service, 2003). Shiri, DVD, 125 min., (Seoul: Kang Je-Kyu Film Co. Ltd., Samsung Entertainment...export-led economic expansion of the Asian tigers (South Korea, Malaysia , Singapore, Thailand, and Indonesia) and the extraordinary trade performance...DVD, 125 min., (Seoul: Kang Je-Kyu Film Co. Ltd., Samsung Entertainment, 2003). Additional Readings “Anti-Kim Front: DPRK Military May Revolt
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2010-01-01
Background Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I is the notorious point mutation that causes resistance to imatinib and the second generation tyrosine kinase inhibitors, leading to poor prognosis. CML blasts have constitutive p65 (RelA NF-κB) transcriptional activity, and NF-κB may be a potential target for molecular therapies in CML that may also be effective against CML cells with Bcr-Abl-T315I. Results In this report, we discovered that pristimerin, a quinonemethide triterpenoid isolated from Celastraceae and Hippocrateaceae, inhibited growth and induced apoptosis in CML cells, including the cells harboring Bcr-Abl-T315I mutation. Additionally, pristimerin inhibited the growth of imatinib-resistant Bcr-Abl-T315I xenografts in nude mice. Pristimerin blocked the TNFα-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB-regulated genes. Pristimerin inhibited two steps in NF-κB signaling: TAK1→IKK and IKK→IκBα. Pristimerin potently inhibited two pairs of CML cell lines (KBM5 versus KBM5-T315I, 32D-Bcr-Abl versus 32D-Bcr-Abl-T315I) and primary cells from a CML patient with acquired resistance to imatinib. The mRNA and protein levels of Bcr-Abl in imatinib-sensitive (KBM5) or imatinib-resistant (KBM5-T315I) CML cells were reduced after pristimerin treatment. Further, inactivation of Bcr-Abl by imatinib pretreatment did not abrogate the TNFα-induced NF-κB activation while silencing p65 by siRNA did not affect the levels of Bcr-Abl, both results together indicating that NF-κB inactivation and Bcr-Abl inhibition may be parallel independent pathways. Conclusion To our knowledge, this is the first report to show that pristimerin is effective in vitro and in vivo against CML cells, including those with the T315I mutation. The mechanisms may involve inhibition of NF-κB and Bcr-Abl. We concluded that pristimerin could be a lead compound for further drug development to
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Lin, Pei-Jung; Winn, Aaron N; Parsons, Susan K; Neumann, Peter J; Weiss, Elisa S; Cohen, Joshua T
2016-04-01
The high prices of chronic myeloid leukemia (CML) therapy are well recognized, but less discussion has focused on the value of health care spending on the disease. This study examined whether the added costs have been "worth" the benefits among older adults with CML. We analyzed trends in health care costs and survival over time of 2164 CML patients over age 65 using the Surveillance, Epidemiology and End Results-Medicare-linked database. We estimated life expectancy over a 15-year duration after diagnosis using a Weibull survival model and projected the corresponding costs using a 2-part model, adjusting for patient characteristics. We estimated population-level survival, total health care costs, and incremental cost-effectiveness ratios (expressed as cost per life year gained) over the period of 1995-2007. We found that therapeutic improvements in the treatment of CML have been associated with survival gains among older adults. Mean life expectancy was 2.2 years in 1995 and increased to 4.2 years in 2007. During the same timeframe, CML care costs have increased, from $127,000 in 1995 to $278,000 in 2007 (2010 dollars), mostly due to increasing tyrosine kinase inhibitor costs. The aggregated incremental cost-effectiveness ratio was $74,000/life year gained. Our findings showed that, despite high costs, CML care may provide reasonable value for money among older patients between 1995-2007. Our study sheds light on the value of health care spending on CML by considering both the costs and the benefits. Future research should investigate strategies to improve treatment adherence to maximize the value of CML care.
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The effect of a clinical medical librarian on in-patient care outcomes.
Esparza, Julia M; Shi, Runhua; McLarty, Jerry; Comegys, Marianne; Banks, Daniel E
2013-07-01
The research sought to determine the effect of a clinical medical librarian (CML) on outcomes of in-patients on the internal medicine service. A prospective study was performed with two internal medicine in-patient teams. Team 1 included a CML who accompanied the team on daily rounds. The CML answered questions posed at the point of care immediately or in emails post-rounds. Patients on Team 2, which did not include a CML, as well as patients who did not require consultation by the CML on Team 1, served as the control population. Numerous clinical and library metrics were gathered on each question. Patients on Team 1 who required an answer to a clinical question were more ill and had a longer length of stay, higher costs, and higher readmission rates compared to those in the control group. Using a matched pair analysis, we showed no difference in clinical outcomes between the intervention group and the control group. This study is the largest attempt to prospectively measure changes in patient outcomes when physicians were accompanied by a CML on rounds. This approach may serve as a model for further studies to define when and how CMLs are most effective.
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Directory of Open Access Journals (Sweden)
Cesarina Giallongo
Full Text Available Tumor immune tolerance can derive from the recruitment of suppressor cell population, including myeloid derived suppressor cells (MDSCs, able to inhibit T cells activity. We identified a significantly expanded MDSCs population in chronic myeloid leukemia (CML patients at diagnosis that decreased to normal levels after imatinib therapy. In addition, expression of arginase 1 (Arg1 that depletes microenvironment of arginine, an essential aminoacid for T cell function, resulted in an increase in patients at diagnosis. Purified CML CD11b+CD33+CD14-HLADR- cells markedly suppressed normal donor T cell proliferation in vitro. Comparing CML Gr-MDSCs to autologous polymorphonuclear leukocytes (PMNs we observed a higher Arg1 expression and activity in PMNs, together with an inhibitory effect on T cells in vitro. Our data indicate that CML cells create an immuno-tolerant environment associated to MDSCs expansion with immunosuppressive capacity mediated by Arg1. In addition, we demonstrated for the first time also an immunosuppressive activity of CML PMNs, suggesting a strong potential immune escape mechanism created by CML cells, which control the anti-tumor reactive T cells. MDSCs should be monitored in imatinib discontinuation trials to understand their importance in relapsing patients.
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Determination of advanced glycation endproducts in cooked meat products.
Chen, Gengjun; Smith, J Scott
2015-02-01
Advanced glycation endproducts (AGEs), a pathogenic factor implicated in diabetes and other chronic diseases, are produced in cooked meat products. The objective of this study was to determine the AGE content, as measured by Nε-carboxymethyllysine (CML) levels, in cooked chicken, pork, beef and fish (salmon and tilapia) prepared by three common cooking methods used by U.S. consumers: frying, baking, and broiling. The CML was detected in all the cooked samples, but the levels were dependent on types of meat, cooking conditions, and the final internal temperature. Broiling and frying at higher cooking temperature produced higher levels of CML, and broiled beef contained the highest CML content (21.8μg/g). Baked salmon (8.6μg/g) and baked tilapia (9.7μg/g) contained less CML as compared to the other muscle food samples. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Molecular techniques for the personalised management of patients with chronic myeloid leukaemia.
Alikian, Mary; Gale, Robert Peter; Apperley, Jane F; Foroni, Letizia
2017-03-01
Chronic myeloid leukemia (CML) is the paradigm for targeted cancer therapy. RT-qPCR is the gold standard for monitoring response to tyrosine kinase-inhibitor (TKI) therapy based on the reduction of blood or bone marrow BCR-ABL1 . Some patients with CML and very low or undetectable levels of BCR-ABL1 transcripts can stop TKI-therapy without CML recurrence. However, about 60 percent of patients discontinuing TKI-therapy have rapid leukaemia recurrence. This has increased the need for more sensitive and specific techniques to measure residual CML cells. The clinical challenge is to determine when it is safe to stop TKI-therapy. In this review we describe and critically evaluate the current state of CML clinical management, different technologies used to monitor measurable residual disease (MRD) focus on comparingRT-qPCR and new methods entering clinical practice. We discuss advantages and disadvantages of new methods.
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Directory of Open Access Journals (Sweden)
Marianna Greco
2013-01-01
Full Text Available Chronic myeloid leukemia (CML with the rare fusion gene e19a2, encoding a p230 protein, has been described in patients with typical or rather aggressive clinical course. Although tyrosine kinase inhibitors (TKIs induce a substantial cytogenetic and molecular response in all phases of CML, a minority of p230 positive patients have been treated with TKIs. We report two cases of CML patients carrying the p230 transcript, who achieved fast and deep complete molecular response (CMR after frontline treatment with nilotinib. Our results suggest the use of nilotinib as frontline agent for the treatment of this CML variant.
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Room temperature ferromagnetism of nanocrystalline Nd1.90Ni0.10O3-δ
Sarkar, B. J.; Mandal, J.; Dalal, M.; Bandyopadhyay, A.; Chakrabarti, P. K.
2018-05-01
Nanocrystalline sample of Ni2+ doped neodymium oxide (Nd1.90Ni0.10O3-δ, NNO) is synthesized by co-precipitation method. Analysis of X-ray diffraction (XRD) pattern by Rietveld refinement method confirms the desired phase of NNO and complete substitution of Ni2+ ions in the Nd2O3 lattice. Analyses of transmission electron microscopy (TEM) and Raman spectroscopy of NNO recorded at room temperature (RT) also substantiate this fact. Besides, no traces of impurities are found in the analyses of XRD, TEM and Raman data. Room temperature hysteresis loop of NNO suggests the presence of weak ferromagnetism (FM) in low field region ( 600 mT), but in high field region paramagnetism of the host is more prominent. Magnetization vs. temperature ( M- T) curve in the entire temperature range (300-5 K) is analyzed successfully by a combined equation generated from three-dimensional (3D) spin wave model and Curie-Weiss law, which suggests the presence of mixed paramagnetic phase together with ferromagnetic phase in the doped sample. The onset of magnetic ordering is analyzed by oxygen vacancy mediated F-center exchange (FCE) coupling mechanism.
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Synthetical analysis of the spin assignment for the superdeformed bands in A≅190 region
International Nuclear Information System (INIS)
Di Yaomin
2002-01-01
The spin assignment for the superdeformed bands of even-even nuclei in A ≅190 region is given by means of using the method of synthetical analysis. The I( I + 1) expression is used to fit the experimental data of the transition γ energies. In contrast to other procedure, the convergence process of the series expansions is put stress upon, whereas taking how many terms exactly in the expression does not emphasized. Moreover as well as the method of fitting the physical quantity, by use of these series expansions the moment of inertia of band heads is also calculated and then the systematics is used for the spin assignments. In practice, when the experimental data is abundant the systematics of the moment of inertia of band heads is more efficient than the method of fitting the physical quantity in the spin assignment. As for a few bands which spin assignment is difficult, the deviation from the typical rotational bands must be considered, which may be judged easily from the second class of moment of inertia of the bands. Finally the results of the spin assignment and the comparison with other literature are presented. These results should be more reliable
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Directory of Open Access Journals (Sweden)
Paras Nuwal
2012-01-01
Full Text Available Pleural effusion in patients with chronic myeloid leukemia (CML is very rare and poorly understood. We report here a 26-year-old male patient having CML and presenting with pleural effusion as the first clinical sign. The possible mechanism of pleural effusion in CML, the cytological interpretive problem and the clinical significance of finding immature leucocytes in pleural fluid are also briefly discussed.
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The decay-out of superdeformed bands in the A = 190 region. What have we learned?
International Nuclear Information System (INIS)
Lauritsen, T.; Hackman, G.; Khoo, T.L.; Carpenter, M.P.; Janssens, R.V.F.; Ackermann, D.; Ahmad, I.; Blumenthal, D.J.; Lopez-Martens, A.
1997-01-01
One-step decay transitions linking the superdeformed (SD) bands 1 and 3 in 194 Hg to yrast levels are discussed. Inter-band transitions between bands 1 and 3 have also been identified. For the first time, the spin, parity and excitation energy have been determined for two SD bands in the same nucleus. The low excitation energy of the excited band supports the view that it is based on an octupole excitation. It is believed that Porter-Thomas fluctuations play a major role in determining the strength of the one-step transitions as suggested by the fact that only one other SD band has been linked in the A = 190 mass region ( 194 Pb) at the present time. When Porter-Thomas fluctuations prevent the observation of one-step or two-step linking transitions, as e.g. in the case of 192 Hg, the analysis of the quasi-continuous part of the decay-out spectrum provides an alternative method for the determination of the excitation energy and spin of an SD band. This method is discussed in detail. (author)
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Chronic Myelogenous Leukemia (CML)
... talk about donating their baby's cord blood College football player stays true to his commitment Be the ... appointment, the transplant doctor will: Review your medical history Talk with you about your treatment options Discuss ...
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2007-02-01
to a fulminant acute leukemic disorder in which patients die of bleeding and infection (1). Allogeneic bone marrow transplantation was the first...acetylenes were created in one step by the coupling of a propiolate anion and isocyanate. These acetylenes were then used as a precursor in the synthesis of...the furans. The furan synthesis was based on early research in the Austin laboratory, which was centered on the concept of adapting the 1,3-dipolar
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Recchia, Anna Grazia; Caruso, Nadia; Bossio, Sabrina; Pellicanò, Mariavaleria; De Stefano, Laura; Franzese, Stefania; Palummo, Angela; Abbadessa, Vincenzo; Lucia, Eugenio; Gentile, Massimo; Vigna, Ernesto; Caracciolo, Clementina; Agostino, Antolino; Galimberti, Sara; Levato, Luciano; Stagno, Fabio; Molica, Stefano; Martino, Bruno; Vigneri, Paolo; Di Raimondo, Francesco; Morabito, Fortunato
2015-01-01
Chronic Myeloid Leukemia (CML) is characterized by a balanced translocation juxtaposing the Abelson (ABL) and breakpoint cluster region (BCR) genes. The resulting BCR-ABL1 oncogene leads to increased proliferation and survival of leukemic cells. Successful treatment of CML has been accompanied by steady improvements in our capacity to accurately and sensitively monitor therapy response. Currently, measurement of BCR-ABL1 mRNA transcript levels by real-time quantitative PCR (RQ-PCR) defines critical response endpoints. An antibody-based technique for BCR-ABL1 protein recognition could be an attractive alternative to RQ-PCR. To date, there have been no studies evaluating whether flow-cytometry based assays could be of clinical utility in evaluating residual disease in CML patients. Here we describe a flow-cytometry assay that detects the presence of BCR-ABL1 fusion proteins in CML lysates to determine the applicability, reliability, and specificity of this method for both diagnosis and monitoring of CML patients for initial response to therapy. We show that: i) CML can be properly diagnosed at onset, (ii) follow-up assessments show detectable fusion protein (i.e. relative mean fluorescent intensity, rMFI%>1) when BCR-ABL1IS transcripts are between 1–10%, and (iii) rMFI% levels predict CCyR as defined by FISH analysis. Overall, the FCBA assay is a rapid technique, fully translatable to the routine management of CML patients. PMID:26111048
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Directory of Open Access Journals (Sweden)
Anna Grazia Recchia
Full Text Available Chronic Myeloid Leukemia (CML is characterized by a balanced translocation juxtaposing the Abelson (ABL and breakpoint cluster region (BCR genes. The resulting BCR-ABL1 oncogene leads to increased proliferation and survival of leukemic cells. Successful treatment of CML has been accompanied by steady improvements in our capacity to accurately and sensitively monitor therapy response. Currently, measurement of BCR-ABL1 mRNA transcript levels by real-time quantitative PCR (RQ-PCR defines critical response endpoints. An antibody-based technique for BCR-ABL1 protein recognition could be an attractive alternative to RQ-PCR. To date, there have been no studies evaluating whether flow-cytometry based assays could be of clinical utility in evaluating residual disease in CML patients. Here we describe a flow-cytometry assay that detects the presence of BCR-ABL1 fusion proteins in CML lysates to determine the applicability, reliability, and specificity of this method for both diagnosis and monitoring of CML patients for initial response to therapy. We show that: i CML can be properly diagnosed at onset, (ii follow-up assessments show detectable fusion protein (i.e. relative mean fluorescent intensity, rMFI%>1 when BCR-ABL1IS transcripts are between 1-10%, and (iii rMFI% levels predict CCyR as defined by FISH analysis. Overall, the FCBA assay is a rapid technique, fully translatable to the routine management of CML patients.
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Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia.
Hattori, Ayuna; Tsunoda, Makoto; Konuma, Takaaki; Kobayashi, Masayuki; Nagy, Tamas; Glushka, John; Tayyari, Fariba; McSkimming, Daniel; Kannan, Natarajan; Tojo, Arinobu; Edison, Arthur S; Ito, Takahiro
2017-05-25
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. However, whether metabolic changes directly regulate cancer development and progression remains poorly understood. Here we show that BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for chronic myeloid leukaemia (CML) in humans and in mouse models of CML. BCAT1 is upregulated during progression of CML and promotes BCAA production in leukaemia cells by aminating the branched-chain keto acids. Blocking BCAT1 gene expression or enzymatic activity induces cellular differentiation and impairs the propagation of blast crisis CML both in vitro and in vivo. Stable-isotope tracer experiments combined with nuclear magnetic resonance-based metabolic analysis demonstrate the intracellular production of BCAAs by BCAT1. Direct supplementation with BCAAs ameliorates the defects caused by BCAT1 knockdown, indicating that BCAT1 exerts its oncogenic function through BCAA production in blast crisis CML cells. Importantly, BCAT1 expression not only is activated in human blast crisis CML and de novo acute myeloid leukaemia, but also predicts disease outcome in patients. As an upstream regulator of BCAT1 expression, we identified Musashi2 (MSI2), an oncogenic RNA binding protein that is required for blast crisis CML. MSI2 is physically associated with the BCAT1 transcript and positively regulates its protein expression in leukaemia. Taken together, this work reveals that altered BCAA metabolism activated through the MSI2-BCAT1 axis drives cancer progression in myeloid leukaemia.
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Soltani, Ismael; Douzi, Kais; Gharbi, Hanen; Benhassine, Islem; Teber, Mouheb; Amouri, Hassiba; Ben Hadj Othman, Hind; Farrah, Ahlem; Ben Lakhel, Raihane; Abbes, Salem; Menif, Samia
2017-05-01
Resistance to imatinib has been recognized as a major challenge for the treatment of chronic myeloid leukemia (CML). Aberrant expression of miR-451 has been reported to participate in anticancer drug resistance. However, the role of miR-451 in imatinib resistance has not been investigated. The present study was undertaken to determine the expression of miR-451 in order to find a possible association between the expression of this miRNA and imatinib resistance in Tunisian CML patients. First, real-time RT-PCR was performed to identify the expression of miR-451 in peripheral leukocytes of 59 CML patients treated with imatinib. Then, bioinformatics analysis was carried out to understand the regulatory roles of miR-451 in imatinib-resistant process. Downregulated miR-451 was observed in imatinib-resistant CML cases. In silico analysis identified MYC as a potential target of miR-451. We further revealed the existence of an MYC-binding site in MiR-451 promoter region. On the other hand, increased level of MYC was detected in imatinib-resistant CML cases which may explain the causative role of MYC in CML cases and the downregulation of miR-451. Taken together, our findings suggest that miR-451 and MYC form together a regulatory loop which may act as a potential therapeutic target, and disruption of suggested regulatory loop could help to improve CML therapy.
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Clinical pathway for patients with Chronic Myeloid Leukaemia: The Euriclea Project.
Botti, Stefano; Gargiulo, Gianpaolo; Bombaci, Felice; Artioli, Giovanna; Cosentino, Chiara; Pignatelli, Adriana Concetta; Torino, Daniela; Lionetti, Maria Marcella; Samarani, Emanuela; Cappucciati, Lorella; Bordiga, Paola; Diodati, Antonella; Caffarri, Cristiana; Rosini, Irene; Pane, Fabrizio
2017-07-18
The use of Tirosine Kinase Ihnibitors (TKIs) for the treatment of Chronic Myeloid Leukemia (CML) has definitely represented a turning point in the treatment of the onco-hematological diseases. Over the years, the interest of physicians, nurses, patients and caregivers has increasingly focused on the aspects of the humanization of care, the management of side effects and on the full and constant therapeutic adherence. The aim of the project was to define patient-oriented care processes, based on a proactive approach that can fully respond to the new health needs of CML patients. A nursing expert Working Group (WG) was established. WG reviewed literature about CML patients assistance and then it was conducted a survey on organizational models for the treatment of CML patients, adopted by Italian haematologic and transplant centers. Finally, the main issues regarding CML patients care were identified and discussed on a multiprofessional basis. Euriclea Project for care of CML patients with the description of a new and expanded nurse role was defined. The Nurse Case Manager or Nursing Clinical Experts were identified as key people for the management of the side effects of treatment, the promotion of the therapeutic adherence and the evaluation of efficacy and effectiveness of the process through the identification of specific indicators for structure, process and outcome. The focal areas of the care process were identified so as to define a different approach to the CML patient, through a holistic view of care and the multidisciplinary interventions.
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Collaborative journalism: the Twitter @plantao190 and police journalism in Curitiba
Directory of Open Access Journals (Sweden)
Bruno Henrique Marques de Mendonça
2013-04-01
Full Text Available This article aims to show how the Internet and the popularization of production tools potentialize the ability of ordinary, amateur people, to produce news, a fact previously reserved to professional journalists in lieu of service communication vehicles. Thus, ownership of technology and the eliminationof geographical barriers, provided by the Internet, helped spread the content of these amateurs, removing the, until then, absolute exclusivity of the journalist to spread facts and disclose information. For this, we carried out a bibliographic review to try and understand how this empowerment process of the amateur started and what are its effects on the practice of journalism. As a theoretical reference, it is possible to highlight authors such as: Dam Gilmor (2005, reference in engaging the topic of evolution of the practice of journalism and collaborative journalism; Francis Pisani & Dominique Piotet (2010, that have dedicated their studies to show the transformation of the web and its impacts on communication, and, finally, author Clay Shirky, who analyses the amateur productions published on the Internet and their relation with its users. As an empirical approach to exemplify the presented theory, a Twitter profile, microblogging tool on which is it possible to post texts with up to 140 characters via mobile devices with an internet connection, was selected. The profile @plantao190 is curated by photographer João Carlos Frigério, who is not a journalist (despite his title, but still informs in real time the police occurrences in the city of Curitiba, becoming a reference in the area and being read by thousands of users who, besides consuming his content, interact and even send their reports which later become new posts.
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The RISC-V Instruction Set Manual Volume 2: Privileged Architecture Version 1.7
2015-05-09
DIG07-10227). Additional support came from Par Lab affiliates Nokia, NVIDIA , Oracle, and Samsung. • Project Isis: DoE Award DE-SC0003624. • ASPIRE...STARnet center funded by the Semiconductor Research Corporation . Additional sup- port from ASPIRE industrial sponsor, Intel, and ASPIRE affiliates...Google, Huawei, Nokia, NVIDIA , Oracle, and Samsung. The content of this paper does not necessarily reflect the position or the policy of the US
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Buetler, Timo M; Leclerc, Estelle; Baumeyer, Alexandra; Latado, Helia; Newell, John; Adolfsson, Oskar; Parisod, Véronique; Richoz, Janique; Maurer, Sarah; Foata, Francis; Piguet, Dominique; Junod, Sylviane; Heizmann, Claus W; Delatour, Thierry
2008-03-01
Advanced glycation endproducts (AGEs) containing carboxymethyllysine (CML) modifications are generally thought to be ligands of the receptor for AGEs, RAGEs. It has been argued that this results in the activation of pro-inflammatory pathways and diseases. However, it has not been shown conclusively that a CML-modified protein can interact directly with RAGE. Here, we have analyzed whether beta-lactoglobulin (bLG) or human serum albumin (HSA) modified chemically to contain only CML (10-40% lysine modification) can (i) interact with RAGE in vitro and (ii) interact with and activate RAGE in lung epithelial cells. Our results show that CML-modified bLG or HSA are unable to bind to RAGE in a cell-free assay system (Biacore). Furthermore, they are unable to activate pro-inflammatory signaling in the cellular system. Thus, CML probably does not form the necessary structure(s) to interact with RAGE and activate an inflammatory signaling cascade in RAGE-expressing cells.
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Willmann, Michael; Sadovnik, Irina; Eisenwort, Gregor; Entner, Martin; Bernthaler, Tina; Stefanzl, Gabriele; Hadzijusufovic, Emir; Berger, Daniela; Herrmann, Harald; Hoermann, Gregor; Valent, Peter; Rülicke, Thomas
2018-01-01
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although the disease can be kept under control using BCR/ABL1 tyrosine kinase inhibitors (TKIs) in most cases, some patients relapse or have resistant disease, so there is a need to identify new therapeutic targets in this malignancy. Recent data suggest that leukemic SCs (LSCs) in CML display the stem-cell (SC)-mobilizing cell surface enzyme dipeptidyl-peptidase IV (DPPIV = CD26) in an aberrant manner. In the present study, we analyzed the effects of the DPPIV blocker vildagliptin as single agent or in combination with the BCR/ABL1 TKI imatinib or nilotinib on growth and survival of CML LSCs in vitro and on LSC engraftment in an in vivo xenotransplantation nonobese diabetic SCID-IL-2Rγ -/- (NSG) mouse model. We found that nilotinib induces apoptosis in CML LSCs and inhibits their engraftment in NSG mice. In contrast, no substantial effects were seen with imatinib or vildagliptin. Nevertheless, vildagliptin was found to reduce the "mobilization" of CML LSCs from a stroma cell layer consisting of mouse fibroblasts in an in vitro co-culture model, suggesting reduced disease expansion. However, although vildagliptin and nilotinib produced cooperative effects in individual experiments, overall, no significant effects of coadministered vildagliptin over nilotinib or imatinib treatment alone were seen on the engraftment of CML cells in NSG mice. Gliptins may be interesting drugs in the context of CML and nilotinib therapy, but our preclinical studies did not reveal a major cooperative effect of the drug-combination vildagliptin + nilotinib on engraftment of CML cells in NSG mice. Copyright © 2018 ISEH – Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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de Jong, Wibe A; Walker, Andrew M; Hanwell, Marcus D
2013-05-24
Multidisciplinary integrated research requires the ability to couple the diverse sets of data obtained from a range of complex experiments and computer simulations. Integrating data requires semantically rich information. In this paper an end-to-end use of semantically rich data in computational chemistry is demonstrated utilizing the Chemical Markup Language (CML) framework. Semantically rich data is generated by the NWChem computational chemistry software with the FoX library and utilized by the Avogadro molecular editor for analysis and visualization. The NWChem computational chemistry software has been modified and coupled to the FoX library to write CML compliant XML data files. The FoX library was expanded to represent the lexical input files and molecular orbitals used by the computational chemistry software. Draft dictionary entries and a format for molecular orbitals within CML CompChem were developed. The Avogadro application was extended to read in CML data, and display molecular geometry and electronic structure in the GUI allowing for an end-to-end solution where Avogadro can create input structures, generate input files, NWChem can run the calculation and Avogadro can then read in and analyse the CML output produced. The developments outlined in this paper will be made available in future releases of NWChem, FoX, and Avogadro. The production of CML compliant XML files for computational chemistry software such as NWChem can be accomplished relatively easily using the FoX library. The CML data can be read in by a newly developed reader in Avogadro and analysed or visualized in various ways. A community-based effort is needed to further develop the CML CompChem convention and dictionary. This will enable the long-term goal of allowing a researcher to run simple "Google-style" searches of chemistry and physics and have the results of computational calculations returned in a comprehensible form alongside articles from the published literature.
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Gore, Lia; Kearns, Pamela R; de Martino, Maria Lucia; Lee; De Souza, Carmino Antonio; Bertrand, Yves; Hijiya, Nobuko; Stork, Linda C; Chung, Nack-Gyun; Cardos, Rocio Cardenas; Saikia, Tapan; Fagioli, Franca; Seo, Jong Jin; Landman-Parker, Judith; Lancaster, Donna; Place, Andrew E; Rabin, Karen R; Sacchi, Mariana; Swanink, Rene; Zwaan, C Michel
2018-05-01
Purpose Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for treatment of adults and children with CML-CP. A phase I study determined suitable dosing for children with Philadelphia chromosome-positive (Ph+) leukemias. Methods CA180-226/NCT00777036 is a phase II, open-label, nonrandomized prospective trial of patients 30% for imatinib-resistant/intolerant patients and complete cytogenetic response (CCyR) > 55% for newly diagnosed patients were of clinical interest. Results Of 113 patients with CML-CP, 14 (48%) who were imatinib-resistant/intolerant and 61 (73%) who were newly diagnosed remained on treatment at time of analysis. Major cytogenetic response > 30% was reached by 3 months in the imatinib-resistant/intolerant group and CCyR > 55% was reached by 6 months in the newly diagnosed CML-CP group. CCyR and major molecular response by 12 months, respectively, were 76% and 41% in the imatinib-resistant/intolerant group and 92% and 52% in newly diagnosed CML-CP group. Progression-free survival by 48 months was 78% and 93% in the imatinib-resistant/intolerant and newly diagnosed CML-CP groups, respectively. No dasatinib-related pleural or pericardial effusion, pulmonary edema, or pulmonary arterial hypertension were reported. Bone growth and development events were reported in 4% of patients. Conclusion In the largest prospective trial to date in children with CML-CP, we demonstrate that dasatinib is a safe, effective treatment of pediatric CML-CP. Target responses to first- or second-line dasatinib were met early, and deep molecular responses were observed. Safety of dasatinib in pediatric patients was similar to that observed in adults; however, no cases of pleural or pericardial effusion or pulmonary arterial hypertension were reported.
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Comparison between ground tests and flight data for two static 32 KB memories
International Nuclear Information System (INIS)
Cheynet, Ph.; Velazco, R.; Cheynet, Ph.; Ecoffet, R.; Duzellier, S.; David, J.P.; Loquet, J.G.
1999-01-01
The study concerns two 32 K-byte static memories, one from Hitachi (HM62256) and the other (HM65756) from Matra-MHS. The results correspond to around one year of measurement in high radiation orbit and a total of 268 upsets were detected. As a preliminary conclusion it can be stated that the MHS SRAM is probably at least 4 times more sensitive to SEU (single event upset) than the Hitachi SRAM. The Hitachi memory has exhibited what we call ''stuck-at'' bit errors. This kind of event is identified when the same address and data is found in error (fixed read data) for several consecutive read cycles. A confrontation of SEU rates derived from predictions to those measured in flight has shown that: - error rate is underestimated for HM62256 using standard prediction models, - error rate can be under or over-estimated for HM65756 but the dispersion on heavy-ion ground results does not allow us to conclude. (A.C.)
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Indirectly cooled large thin superconducting CDF solenoid
International Nuclear Information System (INIS)
Kondo, Kunitaka; Mori, Shigeki; Yoshizaki, Ryozo; Saito, Ryusei; Asano, Katsuhiko.
1985-01-01
The manufacturing technique of the indirectly cooled large thin superconducting solenoid for the collider detector facility (CDF solenoid) has been studied through cooperation of University of Tsukuba and the National Laboratory for High Energy Physics of the Ministry of Education of Japan, and the Fermi National Accelerator Laboratory in the U.S. Fabrication and testing of the solenoid has recently been completed by Hitachi. The CDF solenoid has a large-sized thin structure for meeting the requirement by experiments to be applied. Hitachi has thus developed a variety of new technologies including the design standard, coil cooling method, material selection, and manufacturing technique in accordance with experimental data, which were confirmed in a series of analyses and tests made on various prototypes. The CDF solenoid, built using Hitachi's new technologies, is of the world's top class among equipment of this type. This paper outlines the design criteria for the major components employed in the CDF solenoid and the test results of the solenoid. (author)
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DEFF Research Database (Denmark)
Klein, John P.; Keiding, Niels; Shu, Youyi
2000-01-01
CML, donor lymphocyte infusion, leukaemia-free survival, current leukaemia-free survival, statistical methods......CML, donor lymphocyte infusion, leukaemia-free survival, current leukaemia-free survival, statistical methods...
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Occurrence of chronic lymphocytic leukemia in patients with chronic myelogenous leukemia
Directory of Open Access Journals (Sweden)
Pritish K Bhattacharyya
2013-01-01
Full Text Available Chronic lymphocytic leukemia (CLL is the most common leukemia of adults in the western world and constitutes about 33% of all leukemia′s. The incidence of CLL increases with age and are more common in older population. Chronic myeloid leukemia (CML on the contrary occurs in both young adults and elderly and is a chronic myeloproliferative disease that originates from abnormal pluripotent stem cells and results in involvement of multiple hematopoietic lineages, but predominantly myeloid and less commonly lymphoid. Association between CLL and myeloid malignancies (CML, acute myeloid leukemia and MDS, myelodysplastic syndrome is rare. In literature documenting CLL and CML in same patients, occur either simultaneously or CML is preceded by CLL.
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Dose calculations for the concrete water tunnels at 190-C Area, Hanford Site
International Nuclear Information System (INIS)
Kamboj, S.; Yu, C.
1997-01-01
The RESRAD-BUILD code was used to calculate the radiological dose from the contaminated concrete water tunnels at the 190-C Area at the Hanford Site. Two exposure scenarios, recreationist and maintenance worker, were considered. A residential scenario was not considered because the material was assumed to be left intact (i.e., the concrete would not be rubbleized because the location would not be suitable for construction of a house). The recreationist was assumed to use the tunnel for 8 hours per day for 1 week as an overnight shelter. The maintenance worker was assumed to spend 20 hours per year working in the tunnel. Six exposure pathways were considered in calculating the dose. Three external exposure pathways involved penetrating radiation emitted directly from the contaminated tunnel floor, emitted from radioactive particulates deposited on the tunnel floor, and resulting from submersion in airborne radioactive particulates. Three internal exposure pathways involved inhalation of airborne radioactive particulates; inadvertent direct ingestion of removable, contaminated material on the tunnel floor; and inadvertent indirect ingestion of airborne particulates deposited on the tunnel floor. The gradual removal of surface contamination over time and the ingrowth of decay products were considered in calculating the dose at different times. The maximum doses were estimated to be 1.5 mrem/yr for the recreationist and 0.34 mrem/yr for the maintenance worker
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Abollo-Jiménez, Fernando; Campos-Sánchez, Elena; Toboso-Navasa, Amparo; Vicente-Dueñas, Carolina; González-Herrero, Inés; Alonso-Escudero, Esther; González, Marcos; Segura, Víctor; Blanco, Oscar; Martínez-Climent, José Angel; Sánchez-García, Isidro; Cobaleda, César
2014-01-01
In hematopoietic malignancies, oncogenic alterations interfere with cellular differentiation and lead to tumoral development. Identification of the proteins regulating differentiation is essential to understand how they are altered in malignancies. Chronic myelogenous leukemia (CML) is a biphasic disease initiated by an alteration taking place in hematopoietic stem cells. CML progresses to a blast crisis (BC) due to a secondary differentiation block in any of the hematopoietic lineages. However, the molecular mechanisms of CML evolution to T-cell BC remain unclear. Here, we have profiled the changes in DNA methylation patterns in human samples from BC-CML, in order to identify genes whose expression is epigenetically silenced during progression to T-cell lineage-specific BC. We have found that the CpG-island of the ENGRAILED-2 (EN2) gene becomes methylated in this progression. Afterwards, we demonstrate that En2 is expressed during T-cell development in mice and humans. Finally, we further show that genetic deletion of En2 in a CML transgenic mouse model induces a T-cell lineage BC that recapitulates human disease. These results identify En2 as a new regulator of T-cell differentiation whose disruption induces a malignant T-cell fate in CML progression, and validate the strategy used to identify new developmental regulators of hematopoiesis.
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The effect of a clinical medical librarian on in-patient care outcomes*
Esparza, Julia M.; Shi, Runhua; McLarty, Jerry; Comegys, Marianne; Banks, Daniel E.
2013-01-01
Objective: The research sought to determine the effect of a clinical medical librarian (CML) on outcomes of in-patients on the internal medicine service. Methods: A prospective study was performed with two internal medicine in-patient teams. Team 1 included a CML who accompanied the team on daily rounds. The CML answered questions posed at the point of care immediately or in emails post-rounds. Patients on Team 2, which did not include a CML, as well as patients who did not require consultation by the CML on Team 1, served as the control population. Numerous clinical and library metrics were gathered on each question. Results: Patients on Team 1 who required an answer to a clinical question were more ill and had a longer length of stay, higher costs, and higher readmission rates compared to those in the control group. Using a matched pair analysis, we showed no difference in clinical outcomes between the intervention group and the control group. Conclusions: This study is the largest attempt to prospectively measure changes in patient outcomes when physicians were accompanied by a CML on rounds. This approach may serve as a model for further studies to define when and how CMLs are most effective. PMID:23930088
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Mechanical touch responses of Arabidopsis TCH1-3 mutant roots on inclined hard-agar surface
Zha, Guodong; Wang, Bochu; Liu, Junyu; Yan, Jie; Zhu, Liqing; Yang, Xingyan
2016-01-01
The gravity-induced mechanical touch stimulus can affect plant root architecture. Mechanical touch responses of plant roots are an important aspect of plant root growth and development. Previous studies have reported that Arabidopsis TCH1-3 genes are involved in mechano-related events, how-ever, the physiological functions of TCH1-3 genes in Arabidopsis root mechanoresponses remain unclear. In the present study, we applied an inclined hard agar plate method to produce mechanical touch stimulus, and provided evidence that altered mechanical environment could influence root growth. Furthermore, tch1-3 Arabidopsis mutants were investigated on inclined agar surfaces to explore the functions of TCH1-3 genes on Arabidopsis root mechanoresponses. The results showed that two tch2 mutants, cml24-2 and cml24-4, exhibited significantly reduced root length, biased skewing, and decreased density of lateral root. In addition, primary root length and density of lateral root of tch3 (cml12-2) was significantly decreased on inclined agar surfaces. This study indicates that the tch2 and tch3 mutants are hypersensitive to mechanical touch stimulus, and TCH2 (CML24-2 and CML24-4) and TCH3 (CML12-2) genes may participate in the mechanical touch response of Arabidopsis roots.
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Benefits of obtaining log data in horizontal wells in the WCSB
Energy Technology Data Exchange (ETDEWEB)
Spratt, D. [Reeves Wireline Technologies Ltd., Calgary, AB (Canada)
2001-11-01
A Compact Memory Logging (CML) system developed by Reeves Wireline Technologies was presented. It can be used to obtain log data from horizontal wells to get a better understanding of how to enhance production or completion techniques. The methods that are commonly used to obtain data from horizontal wells include measurement while drilling (MWD), logging while drilling (LWD), wet connect pipe conveyed wireline logging and CML. Each method has its unique benefits that range from information on lithology, rock parameters and fluid interfaces. Reeves has been using wireless pipe conveyed CML over the past two years. The log data includes array induction, dual spaced neutron and photo density porosity, Pe, gamma ray, compensated sonic and hose size caliper. Reeves CML is smaller, easily conveyed and has an unprecedented capability to bend and is considered to be well suited for both newly and previously drilled horizontal wells that require remedial assessment. The tool can be used to determine reservoir quality and boundaries, establish zone structures, or identify fluid interfaces for strategic planning of completions and stimulations. This paper presented examples of logs on some horizontal wells that indicate the value of obtaining log data. Reeves CML is considered to be economically and operationally ideal, particularly since data from the CML includes depth of investigation. 5 figs.
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Giustacchini, Alice; Thongjuea, Supat; Barkas, Nikolaos; Woll, Petter S; Povinelli, Benjamin J; Booth, Christopher A G; Sopp, Paul; Norfo, Ruggiero; Rodriguez-Meira, Alba; Ashley, Neil; Jamieson, Lauren; Vyas, Paresh; Anderson, Kristina; Segerstolpe, Åsa; Qian, Hong; Olsson-Strömberg, Ulla; Mustjoki, Satu; Sandberg, Rickard; Jacobsen, Sten Eirik W; Mead, Adam J
2017-06-01
Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies. However, current single-cell RNA-sequencing approaches lack the sensitivity required to reliably detect somatic mutations. We developed a method that combines high-sensitivity mutation detection with whole-transcriptome analysis of the same single cell. We applied this technique to analyze more than 2,000 SCs from patients with chronic myeloid leukemia (CML) throughout the disease course, revealing heterogeneity of CML-SCs, including the identification of a subgroup of CML-SCs with a distinct molecular signature that selectively persisted during prolonged therapy. Analysis of nonleukemic SCs from patients with CML also provided new insights into cell-extrinsic disruption of hematopoiesis in CML associated with clinical outcome. Furthermore, we used this single-cell approach to identify a blast-crisis-specific SC population, which was also present in a subclone of CML-SCs during the chronic phase in a patient who subsequently developed blast crisis. This approach, which might be broadly applied to any malignancy, illustrates how single-cell analysis can identify subpopulations of therapy-resistant SCs that are not apparent through cell-population analysis.
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Directory of Open Access Journals (Sweden)
Sterfen S. Aquino
2009-01-01
Full Text Available Leucemia mieloide crônica (LMC é uma desordem genética de etiologia desconhecida, caracterizada por crescimento aumentado e não regulado de células precursoras mieloides na medula óssea. LMC está associada com uma característica translocação cromossômica chamada de cromossoma Philadelphia. Esse é um estudo observacional descritivo de pacientes com LMC do Hospital Universitário Walter Cantídio, Universidade Federal de Ceará, Brasil. O objetivo foi estudar a eficácia e a frequência de efeitos colaterais da terapia com mesilato de imatinibe. Vinte e seis pacientes foram incluídos: 09 em fase crônica (34,61%, 06 em fase acelerada (23,08% e 11 em crise blástica (42,31 %. Os casos em fase crônica tiveram intolerância prévia para interferon alfa (IFN- α. Resposta hematológica completa foi observada em sete pacientes, cinco em fase crônica, um em acelerada e um em crise blástica. Durante o primeiro ano de tratamento, quatro pacientes em fase crônica mostraram resposta citogenética completa. Um destes pacientes perdeu a resposta posteriormente. Nenhum paciente em fase acelerada ou crise blástica mostrou resposta citogenética completa. Entre os 18 pacientes que estavam vivos no fim do estudo, apenas quatro (22,22% não tiveram nenhuma queixa. Os mais comuns efeitos adversos foram: edema (50%, adinamia (33,33%, dor óssea e/ou articular (33,33%, cefaléia (27,78%, cãimbra (16,67%, diarreia (16,67%, insônia (16,67%, prurido (16,67%, equimoses (11,11%, náuseas (11,11%, dor epigástrica (5,55%, eritema (5,55%, lacrimejamento (5,55%, ressecamento da pele e lábios (5,55%, rush (5,55%, sudorese (5,55%. Uma minoria de pacientes desenvolveu resistência ao imatinibe. Para superar a resistência e aumentar a resposta positiva aos inibidores de tirosino- quinase novos fármacos e testes estão sendo utilizados e pesquisados.Chronic myeloid leukemia (CML is a genetic disorder of unknown etiology characterized by increased and
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Cheng, Lu; Jin, Cheng; Zhang, Ying
2014-05-01
Baking processing is indispensable to determine special sensory prosperities of cookies and induces the formation of some beneficial components such as antioxidants. However, the formation of some Maillard reaction-derived chemical hazards, such as acrylamide (AA) and N(ε) -(carboxymethyl) lysine (CML) in cookies is also a significant consequence of baking processing from a food safety standpoint. This study investigated the effects of baking conditions on the formation of AA and CML, as well as the antioxidant activity (AOA) of cookies. Cookies were baked at various baking temperatures (155 to 230 °C) and times (1.5 to 31 min). AA and CML contents were determined by ultra-performance liquid chromatography-tandem mass spectrometry, respectively. The highest level of AA was obtained in the cookies baked at 155 °C/21 min and 205 °C/11 min (328.93 ± 3.10 μg/kg and 329.29 ± 5.29 μg/kg), while the highest level of CML was obtained in the cookies baked at 230 °C/1.5 min (118.05 ± 0.21 mg/kg). AA was prone to form at relatively low temperature range (155 to 205 °C), however, CML at relatively high temperature range (205 to 230 °C). The CML content was much higher than the AA content in the same set of cookies, by about 2 to 3 orders of magnitude. The AOA of cookies increased at more severe baking conditions. According to the AA and CML content, AOA and sensory properties of cookies, the temperature-time regime of 180 °C/16 min might be a compromised selection. However, only optimizing the baking condition was not enough for manufacture of high-quality cookies. Cookies, a kind of widely consumed bakery products in the world, contain some potentially harmful compounds, like acrylamide (AA) and N(ε) -(carboxymethyl) lysine (CML). AA in cookies has led to public health concern and several research efforts. But CML, another Maillard reaction-derived chemical hazard, has been neglected so far, even though its content is much higher than that of AA in cookies. The
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Aptitud combinatoria general y especifica de líneas tropicales de maiz usando probadores
Directory of Open Access Journals (Sweden)
Mauro Sierra
2000-01-01
Full Text Available Aptitud combinatoria general y específica de líneas tropicales de maíz usando probadores. Durante el ciclo O - I 1996/97 fueron evaluados en el Campo Experimental Cotaxtla mestizos de líneas sobresalientes y provenientes de varias fuentes de germoplasma como son : a Líneas recicladas de H-513 X VS-536, b Líneas derivadas de un compuesto de amplia base genética, c Líneas élite de programa de maíz de Cotaxtla (LTs y d Líneas de CIMMYT (CMLs. Como probadores se usaron las líneas LT-154 y LT-155 progenitores del híbrido H-513 y las líneas CML247 y CML254 cuya cruza es un patrón heterótico definido por CIMMYT para el trópico. Hubo líneas con buen comportamiento per-se tanto en rendimiento como en características agronómicas y que se encuentran formando mestizos sobresalientes con uno o varios probadores. Con relación a la Aptitud combinatoria, se encontró que las líneas F31XF30-4-3-1, F41XF40-1-2-1, CABG3-12-2-1-2-1-1, LT174 y CML15 registraron los máximos valores con el probador 2 (LT155; F4XF3-5-2-1 y CML15 con el probador 4 (CMl254. Así también, las líneas F4XF5-5-1-1, y CABG3-12-2-1-2-1-1, LT174, CML13 y CML15 con buena ACG. Con relación a los probadores, se encontró que para el grupo de líneas Recicladas , los probadores 1(LT154 y 4 (CML254 registraron los coeficientes de regresión más altos, lo que indica que permiten identificar líneas sobresalientes. Para líneas CABG fué el probador 2 (LT155 el que registró el mejor valor y en líneas Élite , los probadores 2(LT155, y 3(CML247 identificaron mejor a las líneas sobresalientes. Para las líneas del CIMMYT el mejor valor fué para el probador 4(CML254
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Near net shape forming unsing semi-solid metal forming
CSIR Research Space (South Africa)
Govender, G
2005-10-01
Full Text Available (NRC) – UBE • Semi-Solid Rheocasting (SSR) – MIT • New Semi-Solid Casting – Hitachi • Sub-liquidus Casting (SLC) –JLH Technologies & THT Presses • Slurry on Demand (SoD) – AEMP 2005 Contech –USA Citation – USA Intermet – USA Stampal - ITALY... Stampal - producing engine brackets for Fiat PUNTO 50000 pcs per month New Rheocasting (NRC) - UBE 2005 Semi-Solid Rheocasting – MIT 2005 Hitachi Process 2005 SLC Process 2005 Advantages and Disadvantages of Rheocasting Advantages Disadvantages...
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Electronics Industry Study Report
2005-01-01
nearest rival, Korea’s Samsung , by a factor of 2:1 with more than $30 billion in sales and $7.5 billion profit in 2004, although Intel has been losing...firms, conversely, have built their reputations and sales volume on lower end commodities. Korea’s Samsung , and Germany’s Infineon, for example, are...facilities in China, Costa Rica, Ireland, Israel, Malaysia , and the Philippines.14 Texas Instruments has over 15,000 employees in production
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Electronics Industry Study Report: Semiconductors and Defense Electronics
2003-01-01
Access Memory (DRAM) chips and microprocessors. Samsung , Micron, Hynix, and Infineon control almost three-fourths of the DRAM market,8 while Intel alone...Country 2001 Sales ($B) 2002 Sales ($B) % Change % 2002 Mkt 1 1 Intel U.S. 23.7 24.0 1% 16.9% 2 3 Samsung Semiconductor S. Korea 6.3...located in four major regions: the United States, Europe, Japan, and the Asia-Pacific region (includes South Korea, China, Singapore, Malaysia , Taiwan
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Description of identical superdeformed bands of the A ∝ 190 mass region
International Nuclear Information System (INIS)
Dadwal, Anshul; Mittal, H.M.
2017-01-01
The two-parameter formula/model viz. nuclear softness (NS) formula, semiclassical particle rotor model (PRM) and exponential model with pairing attenuation are used for the reliable phenomenological analysis of identical superdeformed bands. These formulae/models are employed to study the identical superdeformed bands of the A ∝ 190 mass region, {"1"9"1Hg(2), "1"9"3Hg(2)}, {"1"9"1Hg(3), "1"9"3Hg(3)}, {"1"9"3Tl(3), "1"9"3Tl(5)}, {"1"9"3Tl(1), "1"9"4Tl(3)}, {"1"9"3Tl(1), "1"9"4Tl(4)}, {"1"9"3Pb(3), "1"9"1Hg(2)}, {"1"9"3Pb(4), "1"9"1Hg(3)}, {"1"9"4Pb(1), "1"9"2Hg(1)}, {"1"9"4Pb(1), "1"9"4Hg(1)} and middle-point identical bands {"1"9"3Tl(1), "1"9"3Tl(2)}, {"1"9"3Tl(1), "1"9"5Tl(1)} and {"1"9"3Tl(2), "1"9"5Tl(2)}. Quantitatively, good results of γ-ray transitions energies and dynamic moment of inertia are obtained using the NS formula. The parameters, band-head moment of inertia (I_0), alignment (i) and effective pairing parameter (Δ_0) are calculated using the least-squares fitting of the γ-ray transitions energies in the NS formula, semiclassical PRM and exponential model with pairing attenuation, respectively. The calculated parameters are found to depend sensitively on the proposed band-head spin. (orig.)