Detection of Histoplasma capsulatum in Organic Fertilizers by Hc100 Nested Polymerase Chain Reaction and Its Correlation with the Physicochemical and Microbiological Characteristics of the Samples.

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Gómez, Luisa F; Torres, Isaura P; Jiménez-A, María Del Pilar; McEwen, Juan Gmo; de Bedout, Catalina; Peláez, Carlos A; Acevedo, José M; Taylor, María L; Arango, Myrtha

2018-05-01

Histoplasma capsulatum is the causative agent of histoplasmosis and this fungus inhabits soils rich in phosphorus and nitrogen that are enriched with bird and bat manure. The replacement of organic matter in agroecosystems is necessary in the tropics, and the use of organic fertilizers has increased. Cases and outbreaks due to the presence of the fungus in these components have been reported. The Instituto Colombiano Agropecuario resolution 150 of 2003 contains the parameters set by the Colombian Technical Standard (NTC 5167) on the physicochemical and microbiological features of fertilizers, but it does not regulate the search for H. capsulatum . The aim of this study was to demonstrate H. capsulatum presence in organic fertilizers by nested polymerase chain reaction (PCR). A total of 239 samples were collected: 201 (84.1%) corresponded to organic fertilizers, 30 (12.5%) to bird excrement, and 8 (3.4%) to cave soils. The Hc100 nested PCR had a detection limit of 0.1 pg/µL and a specificity of 100%. A total of 25 (10.5%) samples were positive and validated by sequencing. Seven of the positive samples represented locations where H. capsulatum was previously detected, suggesting the persistence of the fungus. No significant correlations were detected between the physicochemical and microbiological parameters with the presence of H. capsulatum by nested PCR, indicating the fungus existence in organic fertilizers that complied with the NTC 5167. The Hc100 nested PCR targeting H. capsulatum standardized in this work will improve the evaluation of organic fertilizers and ensure the prevention of outbreaks and cases due to manufacturing, marketing, and use of fertilizers contaminated with H. capsulatum .

21 CFR 866.3320 - Histoplasma capsulatum serological reagents.

Science.gov (United States)

2010-04-01

... SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Serological Reagents § 866.3320... capsulatum from clinical specimens or cultured isolates derived from clinical specimens. The identification...

Contribution to the study of the mycobiota present in the natural habitats of Histoplasma capsulatum: an integrative study in Guerrero, Mexico Contribución al conocimiento de la micobiota presente en los hábitats naturales de Histoplasma capsulatum: un estudio integral en Guerrero, México

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Miguel Ulloa

2006-12-01

Full Text Available The mycobiota present in natural habitats of Histoplasma capsulatum was determined in samples of bat guano, poultry droppings, and intestinal contents of bats. The following fungi were isolated: 1 from bat guano: the ascomycetes Aphanoascus fulvescens, Gymnascella citrina, Gymnoascus dankaliensis, and Chaetomidium fimeti; the mitosporic fungi Aspergillus flavo-furcatis, A. terreus, A. terreus var. aureus, Penicillium spp., Malbranchea aurantiaca, and Sporothrix sp.; and the yeasts Candida catenulata, C. ciferrii, C. famata var. flareri, C. guilliermondii var. guilliermondii, and Rhodotorula spp. 2 from poultry droppings: the coelomycete Phoma sp.; and the yeasts C. albicans, C. catenulata, C. ciferrii, C. famata var. flareri, C. tropicalis, Cryptococcus albidus, Trichosporon moniliiforme, and Trichosporon spp. 3 from the intestinal contents of insectivorous, hematophagous, nectarivorous, and frugivorous bats: Ch. fimeti; the mitosporic fungi Aspergillus candidus, A. flavo-furcatis, A. sulphureus, A. sydowii, A. terreus, A. versicolor, Aspergillus sp., M. aurantiaca, Gliomastix murorum, and Scopulariopsis sp.; and C. famata var. flareri, C. lipolytica, Cr. albidus, and Trichosporon spp. Most of the species found are first records for these substrata and environments in Mexico. The coexistence with H. capsulatum was demonstrated by high specific antibody titers in ELISA serological method, using sera from BALB/c mice previously inoculated with the supernatant of the different samples studied.Se determinó la micobiota presente en diferentes hábitats naturales de Histoplasma capsulatum, como guano de murciélago, excretas de aves de corral, y contenido intestinal de murciélagos. Se aislaron: 1 de guano: los ascomicetes Aphanoascus fulvescens, Gymnascella citrina, Gymnoascus dankaliensis, y Chaetomidium fimeti; los hongos mitospóricos Aspergillus flavo-furcatis, A. terreus, A. terreus var. aureus, Penicillium spp., Malbranchea aurantiaca, y

Development and Evaluation of a Molecular Diagnostic Method for Rapid Detection of Histoplasma capsulatum var. farciminosum, the Causative Agent of Epizootic Lymphangitis, in Equine Clinical Samples

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Pinchbeck, G. L.; Loughnane, P.; Aklilu, N.; Ashine, T.; Stringer, A. P.; Gordon, L.; Marshall, M.; Christley, R. M.

2016-01-01

Histoplasma capsulatum var. farciminosum, the causative agent of epizootic lymphangitis (EZL), is endemic in parts of Africa. Diagnosis based on clinical signs and microscopy lacks specificity and is a barrier to further understanding this neglected disease. Here, a nested PCR method targeting the internal transcribed spacer (ITS) region of the rRNA operon was validated for application to equine clinical samples. Twenty-nine horses with signs of EZL from different climatic regions of Ethiopia were clinically examined. Blood samples and aspirates of pus from cutaneous nodules were taken, along with blood from a further 20 horses with no cutaneous EZL lesions. Among the 29 horses with suspected cases of EZL, H. capsulatum var. farciminosum was confirmed by extraction of DNA from pus and blood samples from 25 and 17 horses, respectively. Positive PCR results were also obtained with heat-inactivated pus (24 horses) and blood (23 horses) spotted onto Whatman FTA cards. Two positive results were obtained among blood samples from 20 horses that did not exhibit clinical signs of EZL. These are the first reports of the direct detection of H. capsulatum var. farciminosum in equine blood and at high frequency among horses exhibiting cutaneous lesions. The nested PCR outperformed conventional microscopic diagnosis, as characteristic yeast cells could be observed only in 14 pus samples. The presence of H. capsulatum var. farciminosum DNA was confirmed by sequencing the cloned PCR products, and while alignment of the ITS amplicons showed very little sequence variation, there was preliminary single nucleotide polymorphism-based evidence for the existence of two subgroups of H. capsulatum var. farciminosum. This molecular diagnostic method now permits investigation of the epidemiology of EZL. PMID:27707938

Antibody Binding Alters the Characteristics and Contents of Extracellular Vesicles Released by Histoplasma capsulatum

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Baltazar, Ludmila M.; Nakayasu, Ernesto S.; Sobreira, Tiago; Choi, Hyungwon; Casadevall, Arturo; Nimrichter, Leonardo; Nosanchuk, Joshua D.

2016-03-30

Histoplasma capsulatumproduces extracellular vesicles containing virulence-associated molecules capable of modulating host machinery, benefiting the pathogen. Treatment ofH. capsulatumcells with monoclonal antibodies (MAbs) can change the outcome of infection in mice. We evaluated the sizes, enzymatic contents, and proteomic profiles of the vesicles released by fungal cells treated with either protective MAb 6B7 (IgG1) or nonprotective MAb 7B6 (IgG2b), both of which bindH. capsulatumheat shock protein 60 (Hsp60). Our results showed that treatment with either MAb was associated with changes in size and vesicle loading. MAb treatments reduced vesicle phosphatase and catalase activities compared to those of vesicles from untreated controls. We identified 1,125 proteins in vesicles, and 250 of these manifested differences in abundance relative to that of proteins in vesicles isolated from yeast cells exposed to Hsp60-binding MAbs, indicating that surface binding of fungal cells by MAbs modified protein loading in the vesicles. The abundance of upregulated proteins in vesicles upon MAb 7B6 treatment was 44.8% of the protein quantities in vesicles from fungal cells treated with MAb 6B7. Analysis of orthologous proteins previously identified in vesicles from other fungi showed that different ascomycete fungi have similar proteins in their extracellular milieu, many of which are associated with virulence. Our results demonstrate that antibody binding can modulate fungal cell responses, resulting in differential loading of vesicles, which could alter fungal cell susceptibility to host defenses. This finding provides additional evidence that antibody binding modulates microbial physiology and suggests a new function for specific immunoglobulins through alterations of fungal secretion.

IMPORTANCEDiverse fungal species release extracellular vesicles, indicating that this is a

Multiple skeletal lesions and pleural effusion owing to Histoplasma ...

African Journals Online (AJOL)

We describe a rare case of multiple skeletal lesions and a pleural effusion owing to Histoplasma capsulatum infection in a 16-year-old immunocompetent girl residing in a non-endemic region. Of note is that she had a lesion within a thoracic vertebra. Following an extensive literature search, we found that vertebral ...

Development and Evaluation of a Molecular Diagnostic Method for Rapid Detection of Histoplasma capsulatum var. farciminosum, the Causative Agent of Epizootic Lymphangitis, in Equine Clinical Samples.

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Scantlebury, C E; Pinchbeck, G L; Loughnane, P; Aklilu, N; Ashine, T; Stringer, A P; Gordon, L; Marshall, M; Christley, R M; McCarthy, A J

2016-12-01

Histoplasma capsulatum var. farciminosum, the causative agent of epizootic lymphangitis (EZL), is endemic in parts of Africa. Diagnosis based on clinical signs and microscopy lacks specificity and is a barrier to further understanding this neglected disease. Here, a nested PCR method targeting the internal transcribed spacer (ITS) region of the rRNA operon was validated for application to equine clinical samples. Twenty-nine horses with signs of EZL from different climatic regions of Ethiopia were clinically examined. Blood samples and aspirates of pus from cutaneous nodules were taken, along with blood from a further 20 horses with no cutaneous EZL lesions. Among the 29 horses with suspected cases of EZL, H. capsulatum var. farciminosum was confirmed by extraction of DNA from pus and blood samples from 25 and 17 horses, respectively. Positive PCR results were also obtained with heat-inactivated pus (24 horses) and blood (23 horses) spotted onto Whatman FTA cards. Two positive results were obtained among blood samples from 20 horses that did not exhibit clinical signs of EZL. These are the first reports of the direct detection of H. capsulatum var. farciminosum in equine blood and at high frequency among horses exhibiting cutaneous lesions. The nested PCR outperformed conventional microscopic diagnosis, as characteristic yeast cells could be observed only in 14 pus samples. The presence of H. capsulatum var. farciminosum DNA was confirmed by sequencing the cloned PCR products, and while alignment of the ITS amplicons showed very little sequence variation, there was preliminary single nucleotide polymorphism-based evidence for the existence of two subgroups of H. capsulatum var. farciminosum This molecular diagnostic method now permits investigation of the epidemiology of EZL. Copyright © 2016 Scantlebury et al.

Comparison of diagnostic methods to detect Histoplasma capsulatum in serum and blood samples from AIDS patients

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da Silva, Marcos Vinicius; Criado, Paulo Ricardo; Luiz, Olinda do Carmo; Vicentini, Adriana Pardini

2018-01-01

Background Although early and rapid detection of histoplasmosis is essential to prevent morbidity and mortality, few diagnostic tools are available in resource-limited areas, especially where it is endemic and HIV/AIDS is also epidemic. Thus, we compared conventional and molecular methods to detect Histoplasma capsulatum in sera and blood from HIV/AIDS patients. Methodology We collected a total of 40 samples from control volunteers and patients suspected of histoplasmosis, some of whom were also infected with other pathogens. Samples were then analyzed by mycological, serological, and molecular methods, and stratified as histoplasmostic with (group I) or without AIDS (group II), uninfected (group III), and infected with HIV and other pathogens only (group IV). All patients were receiving treatment for histoplasmosis and other infections at the time of sample collection. Results Comparison of conventional methods with nested PCR using primers against H. capsulatum 18S rRNA (HC18S), 5.8S rRNA ITS (HC5.8S-ITS), and a 100 kDa protein (HC100) revealed that sensitivity against sera was highest for PCR with HC5.8S-ITS, followed by immunoblotting, double immunodiffusion, PCR with HC18S, and PCR with HC100. Specificity was equally high for double immunodiffusion, immunoblotting and PCR with HC100, followed for PCR with HC18S and HC5.8-ITS. Against blood, sensitivity was highest for PCR with HC5.8S-ITS, followed by PCR with HC18S, Giemsa staining, and PCR with HC100. Specificity was highest for Giemsa staining and PCR with HC100, followed by PCR with HC18S and HC5.8S-ITS. PCR was less efficient in patients with immunodeficiency due to HIV/AIDS and/or related diseases. Conclusion Molecular techniques may detect histoplasmosis even in cases with negative serology and mycology, potentially enabling early diagnosis. PMID:29342162

Comparison of diagnostic methods to detect Histoplasma capsulatum in serum and blood samples from AIDS patients.

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Katia Cristina Dantas

Full Text Available Although early and rapid detection of histoplasmosis is essential to prevent morbidity and mortality, few diagnostic tools are available in resource-limited areas, especially where it is endemic and HIV/AIDS is also epidemic. Thus, we compared conventional and molecular methods to detect Histoplasma capsulatum in sera and blood from HIV/AIDS patients.We collected a total of 40 samples from control volunteers and patients suspected of histoplasmosis, some of whom were also infected with other pathogens. Samples were then analyzed by mycological, serological, and molecular methods, and stratified as histoplasmostic with (group I or without AIDS (group II, uninfected (group III, and infected with HIV and other pathogens only (group IV. All patients were receiving treatment for histoplasmosis and other infections at the time of sample collection.Comparison of conventional methods with nested PCR using primers against H. capsulatum 18S rRNA (HC18S, 5.8S rRNA ITS (HC5.8S-ITS, and a 100 kDa protein (HC100 revealed that sensitivity against sera was highest for PCR with HC5.8S-ITS, followed by immunoblotting, double immunodiffusion, PCR with HC18S, and PCR with HC100. Specificity was equally high for double immunodiffusion, immunoblotting and PCR with HC100, followed for PCR with HC18S and HC5.8-ITS. Against blood, sensitivity was highest for PCR with HC5.8S-ITS, followed by PCR with HC18S, Giemsa staining, and PCR with HC100. Specificity was highest for Giemsa staining and PCR with HC100, followed by PCR with HC18S and HC5.8S-ITS. PCR was less efficient in patients with immunodeficiency due to HIV/AIDS and/or related diseases.Molecular techniques may detect histoplasmosis even in cases with negative serology and mycology, potentially enabling early diagnosis.

Investigation of an optimal cell lysis method for the study of the zinc metalloproteome of Histoplasma capsulatum.

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Donnell, Anna M; Lewis, Stephanie; Abraham, Sami; Subramanian, Kavitha; Figueroa, Julio Landero; Deepe, George S; Vonderheide, Anne P

2017-10-01

This work sought to assess optimal extraction conditions in the study of the metalloproteome of the dimorphic fungus Histoplasma capsulatum. One of the body's responses to H. capsulatum infection is sequestration of zinc within host macrophage (MØ), as reported by Vignesh et al. (Immunity 39:697-710, 2013) and Vignesh et al. (PLOS Pathog 9:E1003815, 2013). Thus, metalloproteins containing zinc were of greatest interest as it plays a critical role in survival of the fungus. One challenge in metalloproteomics is the preservation of the native structure of proteins to retain non-covalently bound metals. Many of the conventional cell lysis, separation, and identification techniques in proteomics are carried out under conditions that could lead to protein denaturation. Various cell lysis techniques were investigated in an effort to both maintain the metalloproteins during lysis and subsequent analysis while, at the same time, serving to be strong enough to break the cell wall, allowing access to cytosolic metalloproteins. The addition of 1% Triton x-100, a non-ionic detergent, to the lysis buffer was also studied. Seven lysis methods were considered and these included: Glass Homogenizer (H), Bead Beater (BB), Sonication Probe (SP), Vortex with 1% Triton x-100 (V, T), Vortex with no Triton x-100 (V, NT), Sonication Bath, Vortex, and 1% Triton x-100 (SB, V, T) and Sonication Bath, Vortex, and no Triton x-100 (SB, V, NT). A Qubit® Assay was used to compare total protein concentration and inductively coupled plasma-mass spectrometry (ICP-MS) was utilized for total metal analysis of cell lysates. Size exclusion chromatography coupled to ICP-MS (SEC-HPLC-ICP-MS) was used for separation of the metalloproteins in the cell lysate and the concentration of Zn over a wide molecular weight range was examined. Additional factors such as potential contamination sources were also considered. A cell lysis method involving vortexing H. capsulatum yeast cells with 500 μm glass beads

Histoplasma capsulatum heat-shock 60 orchestrates the adaptation of the fungus to temperature stress.

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Allan Jefferson Guimarães

2011-02-01

Full Text Available Heat shock proteins (Hsps are among the most widely distributed and evolutionary conserved proteins. Hsps are essential regulators of diverse constitutive metabolic processes and are markedly upregulated during stress. A 62 kDa Hsp (Hsp60 of Histoplasma capsulatum (Hc is an immunodominant antigen and the major surface ligand to CR3 receptors on macrophages. However little is known about the function of this protein within the fungus. We characterized Hc Hsp60-protein interactions under different temperature to gain insights of its additional functions oncell wall dynamism, heat stress and pathogenesis. We conducted co-immunoprecipitations with antibodies to Hc Hsp60 using cytoplasmic and cell wall extracts. Interacting proteins were identified by shotgun proteomics. For the cell wall, 84 common interactions were identified among the 3 growth conditions, including proteins involved in heat-shock response, sugar and amino acid/protein metabolism and cell signaling. Unique interactions were found at each temperature [30°C (81 proteins, 37°C (14 and 37/40°C (47]. There were fewer unique interactions in cytoplasm [30°C (6, 37°C (25 and 37/40°C (39] and four common interactions, including additional Hsps and other known virulence factors. These results show the complexity of Hsp60 function and provide insights into Hc biology, which may lead to new avenues for the management of histoplasmosis.

Molecular detection of Histoplasma capsulatum in insectivorous and frugivorous bats in Southeastern Brazil.

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Dos Santos, Bruna; Langoni, Helio; da Silva, Rodrigo Costa; Menozzi, Benedito Donizete; Bosco, Sandra de Moraes Gimenes; Paiz, Laís Moraes; Augusto, Livia Carla Ramos; Richini-Pereira, Virgínia Bodelão

2017-12-27

Bats are considered to play a significant role in the epidemiology of histoplasmosis, worldwide. We investigated the occurrence of H. capsulatum in lung samples from 89 bats, from urban areas in Southeastern Brazil, using nested PCR based on ribosomal DNA. Fungal DNA was detected in 31/89 samples (34.8%), of which 13/31 were Molossids (41.9%), 4/31 Eumops spp. (12.9%), 2/31 Artibeus lituratus (6.5%), and 12/31 others (38.7%). This is the first report of natural infection by H. capsulatum in A. lituratus in Southeastern Brazil, which reinforces the importance of these synanthropic animals in the epidemiology of histoplasmosis in urban areas. © The Author(s) 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Granulomatous mastitis caused by histoplasma and mimicking inflammatory breast carcinoma.

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Osborne, B M

1989-01-01

Two cases of a lobular, necrotizing granulomatous process causing a unilateral painful breast mass mimicking carcinoma are presented for comparison. While the morphologic appearance in each case was that of lobular granulomatous mastitis, the etiologic agent in one case appeared to be Histoplasma capsulatum, based on Grocott methenamine silver staining, and represents the second reported case of histoplasmosis involving only breast parenchyma. Awareness of the rare entity, granulomatous mastitis, is important for the pathologist because the definitive diagnosis is made microscopically. Thorough evaluation of the breast tissue is essential for its management and should eventually contribute to the clarification of its etiology.

[Preservation of high risk fungal cultures of Histoplasma and Cryptococcus].

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Fernández Andreu, C Carlos Manuel; Díaz Suárez, Luis Alberto; Ilnait Zaragozi, María Teresa; Aragonés López, Carlos; Martínez Machín, Gerardo; Perurena Lancha, Mayda R

2012-01-01

culture collections are responsible for providing the microbial resources for development of biological sciences. Storage in distilled water is one of the easiest and least expensive method for long-term fungal preservation. to evaluate the usefulness of this preservation method in fungal culture of Histoplasma and Cryptococcus. the preservation condition of the highest biological risk species from Histoplasma y Cryptococcus genera, included in the fungal culture collection of "Pedro Kouri" Institute of Tropical Medicine in Havana, was evaluated in this study. One hundred and two strains stored in distilled water, 92% of which had been preserved for more than 10 years, were analyzed. the percentages of recovered strains from H. capsulatum, C. neoformans and C. gattii were 64.3%; 79.1% and 100% respectively. This method of preservation proved to be satisfactory for fungal culture in labs with limited financial resources. A web-based database with interesting information about the collection was made. The importance of strict compliance with the biosafety measures in these collections, particularly with high risk pathogens. preservation of fungal cultures in distilled water is a very useful method for laboratories with limited resources. Culture collections should be assumed as an essential activity in order to solve increasing challenges in the development of biomedical sciences.

Histoplasma meets Crohn's disease: a rare case of new-onset ascites.

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Bosshardt, Charles Robert; Gnann, John; Lodhia, Nilesh

2018-04-17

A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident. The patient completed 2 weeks of liposomal amphotericin B followed by oral itraconazole for 1 year. Adalimumab therapy was held for 10 weeks, then restarted. Presenting symptoms resolved following initiation of antifungal therapy. Follow-up MRI of his abdomen demonstrated resolution of ascites. To our knowledge, this is the first reported case of histoplasmosis presenting as peritonitis in a patient with Crohn's disease receiving antitumour necrosis factor-alpha (TNF-α) therapy. Many clinicians are aware that patients receiving anti-TNF-α therapy are at increased risk for histoplasmosis, but may fail to consider the diagnosis in the absence of lung involvement. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Histoplasma Urinary Antigen Testing Obviates the Need for Coincident Serum Antigen Testing.

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Libert, Diane; Procop, Gary W; Ansari, Mohammad Q

2018-03-07

Serum and urine antigen (SAg, UAg) detection are common tests for Histoplasma capsulatum. UAg detection is more widely used and reportedly has a higher sensitivity. We investigated whether SAg detection contributes meaningfully to the initial evaluation of patients with suspected histoplasmosis. We reviewed 20,285 UAg and 1,426 SAg tests ordered from 1997 to 2016 and analyzed paired UAg and SAg tests completed on the same patient within 1 week. We determined the positivity rate for each test. Of 601 paired specimens, 542 were concurrent negatives and 48 were concurrent positives (98% agreement). Medical records were available for eight of 11 pairs with discrepant results. UAg was falsely positive in six instances, truly positive once, and falsely negative once. These findings support using a single antigen detection test, rather than both UAg and SAg, as an initial screen for suspected histoplasmosis. This aligns with the current practice of most physicians.

Coccidioides posadasii infection in bats, Brazil.

Science.gov (United States)

Cordeiro, Rossana de Aguiar; e Silva, Kylvia Rocha de Castro; Brilhante, Raimunda Sâmia Nogueira; Moura, Francisco Bergson Pinheiro; Duarte, Naylê Francelino Holanda; Marques, Francisca Jakelyne de Farias; Cordeiro, Rebecca de Aguiar; Filho, Renato Evando Moreira; de Araújo, Roberto Wagner Bezerra; Bandeira, Tereza de Jesus Pinheiro Gomes; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

2012-04-01

To analyze the eco-epidemiologic aspects of Histoplasma capsulatum in Brazil, we tested 83 bats for this fungus. Although H. capsulatum was not isolated, Coccidioides posadasii was recovered from Carollia perspicillata bat lungs. Immunologic studies detected coccidioidal antibodies and antigens in Glossophaga soricina and Desmodus rotundus bats.

Coccidioides posadasii Infection in Bats, Brazil

OpenAIRE

Cordeiro, Rossana de Aguiar; Rocha de Castro e Silva, Kylvia; Brilhante, Raimunda Sâmia Nogueira; Moura, Francisco Bergson Pinheiro; Duarte, Naylê Francelino Holanda; Marques, Francisca Jakelyne de Farias; Cordeiro, Rebecca de Aguiar; Filho, Renato Evando Moreira; Bezerra de Araújo, Roberto Wagner; Bandeira, Tereza de Jesus Pinheiro Gomes; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

2012-01-01

To analyze the eco-epidemiologic aspects of Histoplasma capsulatum in Brazil, we tested 83 bats for this fungus. Although H. capsulatum was not isolated, Coccidioides posadasii was recovered from Carollia perspicillata bat lungs. Immunologic studies detected coccidioidal antibodies and antigens in Glossophaga soricina and Desmodus rotundus bats.

Disseminated cutaneous histoplasmosis in an immunocompetent adult

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Manoj Harnalikar

2012-01-01

Full Text Available Histoplasmosis, a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum var capsulatum and Histoplasma capsulatum var duboisii is endemic to many parts of the world. The clinical manifestations range from acute or chronic pulmonary infection to a progressive disseminated disease. After initial exposure to the fungus, the infection is self-limited and restricted to the lungs in 99% of healthy individuals. The remaining 1%, however, progress to either disseminated or chronic disease involving the lungs, liver, spleen, lymph nodes, bone marrow or rarely, the skin and mucous membranes. Mucocutaneous histoplasmosis is frequently reported in patients with acquired immune deficiency syndrome (AIDS, but it is rare in immunocompetent hosts. A 60-year-old male presented with asymptomatic swelling of the hard palate and crusted papules and nodules over the extremities, face and trunk. Clinically, the diagnoses of cutaneous cryptococcosis versus histoplasmosis was considered in this patient. A chest X-ray revealed hilar lymphadenopathy. Enzyme-linked immunosorbent assay (ELISA for human immunodeficiency virus (HIV was nonreactive. Skin biopsy revealed multiple tiny intracellular round yeast forms with a halo in the mid-dermis. Culture of the skin biopsy in Sabouraud′s dextrose agar showed colonies of Histoplasma capsulatum. Despite an investigation including no evidence of underlying immunosuppression was found, he was started on IV amphotericin-B (0.5 mg/kg/day. However, the patient succumbed to his disease 2 days after presentation. We report a rare case of disseminated cutaneous histoplasmosis in an immunocompetent individual.

Non-resolving pneumonia: A rare presentation of progressive disseminated histoplasmosis

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Supriya Sarkar

2014-01-01

Full Text Available Histoplasmosis, a fungal disease caused by Histoplasma capsulatum, is endemic in North and South America. Except few scattered cases, the disease is considered to be a non-entity in India. Furthermore, disseminated histoplasmosis is rare in the immunocompetent individuals. We report an adolescent boy presenting as middle lobe consolidation which did not respond to antibiotics. His condition deteriorated with the development of mediastinal lymphadenopathy, pleural effusion and hepatosplenomegaly. A diagnosis of progressive disseminated histoplasmosis was established by his clinical findings as well as bronchoscopic biopsy, transbronchial needle aspiration cytology and bronchoalveolar lavage culture demonstrating Histoplasma capsulatum. The case represents a unique example of progressive disseminated histoplasmosis in an immunocompetent individual in India.

Histoplasmosis and Paracoccidioidomycosis in northwestern Argentina III. Epidemiological survey in Vipos, La Toma, and Choromoro - Trancas, Tucuman, Argentina

International Nuclear Information System (INIS)

Komaid, Aida van Gelderen de; Duran, Estela; Kestelman, Isabel Borges de

1999-01-01

The present work was undertaken to obtain epidemiological data on the extent and distribution of Histoplasma capsulatum var. capsulatum and Paracoccidiodes brasiliensis diseases in the Vipos, La Toma and Choromoro areas. Skin test surveys with histoplasmin and paracoccidioidin were carried out in the permanent human population of those localities. Mycological sputum studies and serological tests were performed to skin test reactors to determine if there were signs or symptoms of active mycotic disease. La Toma and Choromoro are highly prevalent areas of histoplasmosis ( > 30% the histoplasmin positive individuals) whereas Vipos can be relatively considered a highly prevalent area (between 20-30% the histoplasmin reactors) according to the normally accepted range used to define an endemic disease [2]. Early Histoplasma capsulatum infection ( < 10 years old) is reported for Vipos and Choromoro. La Toma has the highest rate of previous exposure to P. brasiliensis detected in the studied area (10.2%). Vipos residents are not infected with P. brasiliensis

Chronic Progressive Disseminated Mucocutaneous Histoplasmosis

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T P Thankappan

1983-01-01

Full Text Available An unusual case of Histoplasma Capsulatum infection with cutaneous nodules, a feature of African histoplasmosis and granulomatous lesions, a manifestation of classical histoplasmosis is being reported.

75 Years of Histoplasmosis Outbreaks in the United States

Centers for Disease Control (CDC) Podcasts

2016-03-24

Kaitlin Benedict, CDC epidemiologist, discusses Histoplasma capsulatum infection.  Created: 3/24/2016 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 3/24/2016.

Seroprevalencia de micosis pulmonares en pacientes con sintomatología de enfermedad respiratoria crónica baja: Alto Huallaga, Perú 2004

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Walter Gómez

2006-06-01

Full Text Available Objetivo: Detectar por serología la presencia de micosis de localización pulmonar (Paracoccidioides brasiliensis, Aspergillus sp. e Histoplasma capsulatum, en pacientes con síntomas de enfermedad respiratoria crónica. Diseño: Estudio transversal. Lugar: Alto Huallaga (selva de los departamentos de Huánuco y San Martín, Perú. Pacientes: Se incluyó personas procedentes de seis distritos (Rupa Rupa, Tocache, Uchiza, Santa Lucia, Aucayacu y Puerto Inca - Sungaro con diagnóstico de enfermedad respiratoria crónica baja, tres episodios o más de bronquitis al año y/o tos con expectoración por más de tres meses y en quienes se descartó tuberculosis pulmonar mediante baciloscopia directa. Intervenciones: Por cada persona se llenó una ficha clínica-epidemiológica durante abril a septiembre de 2004, seguido de la toma de una muestra de suero (10 mL para las pruebas de inmunodifusión para Histoplasma capsulatum, Paraccocidiodes brasiliensis, Aspergilus sp, y Aspergillus fumigatus. Principales medidas de resultados: Seroprevalencia de micosis a Histoplasma capsulatum, Aspergilosis spp. y Paracoccidioides brasiliensis. Resultados: De 640 casos, 327 (51,1% fueron de sexo masculino, edad promedio 37,1 años y tiempo de enfermedad de 7,4 meses. La seroprevalencia de micosis fue 1,7% (11/640: 4 Histoplasma capsulatum y 7 Aspergilosis spp. No se obtuvo casos positivos de Paracoccidioides brasiliensis y, en los casos positivos, solo se encontró asociación con 'baja de peso' (p = 0,004. Conclusión: Si bien la frecuencia micoserológica obtenida fue baja, se sugiere en esta zona endémica considerar a las micosis dentro del diagnóstico diferencial de casos con enfermedades respiratorias crónicas bajas, así como la utilización de técnicas de inmunodifusión para el diagnóstico de estas etiologías.

Identification of the source of histoplasmosis infection in two captive maras (Dolichotis patagonum from the same colony by using molecular and immunologic assays Identificación de la fuente de infección de histoplasmosis de dos maras (Dolichotis patagonum cautivas procedentes de la misma colonia, utilizando ensayos moleculares e inmunológicos

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M. R. Reyes-Montes

2009-06-01

Full Text Available Histoplasma capsulatum was isolated from the spleen of a first infected mara (Dolichotis patagonum and from a second mara's liver and adrenal gland, both in the same colony at the Africam Safari, Puebla, Mexico. Studies of H. capsulatum isolates, using nested-PCR of a 100-kDa protein coding gene (Hcp100 fragment and a two-primer RAPDPCR method, suggest that these isolates were spreading in the environment of the maras' enclosure. By using a Dot- ELISA method, sera from mice inoculated with three homogenates of soil samples from the maras' enclosed space developed positive brown spot reactions to a purified H. capsulatum antigen, which identified the probable source of the maras' infection.Histoplasma capsulatum fue aislado del bazo de una primera mara (Dolichotis patagonum infectada y del hígado y la glándula suprarrenal de un segundo ejemplar, ambos de la misma colonia en el Africam Safari, Puebla, México. Los estudios de los aislamientos de H. capsulatum mediante PCR anidada para un fragmento del gen Hcp100 que codifica una proteína de 100 kDa y RAPD-PCR empleando doble iniciador sugieren que estos aislamientos estaban dispersos en el ambiente del refugio de las maras. Los sueros de ratones inoculados con tres homogenatos de muestras de suelo del refugio desarrollaron reacciones positivas a un antígeno purificado de H. capsulatum (manchas color castaño oscuro por el método de Dot-ELISA; con lo cual se identificó la probable fuente de infección de las maras.

Aetiological study of the presumed ocular histoplasmosis syndrome in the Netherlands

NARCIS (Netherlands)

Ongkosuwito, J.V.; Kortbeek, L.M.; Lelij, van der A.; Molicka, E.; Kijlstra, A.; Smet, de M.D.; Suttrop-Schulten, M.S.A.

1999-01-01

Aim. To investigate whether presumed ocular histoplasmosis syndrome in the Netherlands is caused by Histoplasma capsulatum and whether other risk factors might play a role in the pathogenesis of this syndrome. Methods. 23 patients were clinically diagnosed as having presumed ocular histoplasmosis

Recurrent poststernotomy mediastinitis due to histoplasmosis: The ...

African Journals Online (AJOL)

This report describes the first case of surgical site infection due to Histoplasma capsulatum. A 4 year-old presented with recurrent thoracotomy surgical site infection (SSI) requiring multiple debridements until the correct diagnosis was performed. This case illustrates the critical role of histopathology in early recognition of ...

Genome sequencing and comparative genomics analysis revealed pathogenic potential in Penicillium capsulatum as a novel fungal pathogen belonging to Eurotiales

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Ying Yang

2016-10-01

Full Text Available Penicillium capsulatum is a rare Penicillium species used in paper manufacturing, but recently it has been reported to cause invasive infection. To research the pathogenicity of the clinical Penicillium strain, we sequenced the genomes and transcriptome of the clinical and environmental strains of P. capsulatum. Comparative analyses of these two P. capsulatum strains and close related strains belonging to Eurotiales were performed. The assembled genome sizes of P. capsulatum are approximately 34.4 Mbp in length and encode 11,080 predicted genes. The different isolates of P. capsulatum are highly similar, with the exception of several unique genes, INDELs or SNP in the genes coding for glycosyl hydrolases, amino acid transporters and circumsporozoite protein. A phylogenomic analysis was performed based on the whole genome data of 38 strains belonging to Eurotiales. By comparing the whole genome sequences and the virulence-related genes from 20 important related species, including fungal pathogens and non-human pathogens belonging to Eurotiales, we found meaningful pathogenicity characteristics between P. capsulatum and its closely related species. Our research indicated that P. capsulatum may be a neglected opportunistic pathogen. This study is beneficial for mycologists, geneticists and epidemiologists to achieve a deeper understanding of the genetic basis of the role of P. capsulatum as a newly reported fungal pathogen.

Fluorescent in situ hybridization of pre-incubated blood culture material for the rapid diagnosis of histoplasmosis.

Science.gov (United States)

da Silva, Roberto Moreira; da Silva Neto, João Ricardo; Santos, Carla Silvana; Cruz, Kátia Santana; Frickmann, Hagen; Poppert, Sven; Koshikene, Daniela; de Souza, João Vicente Braga

2015-02-01

Fluorescence in situ hybridization (FISH) has been shown to be useful for the detection of Candida and Cryptococcus species in blood culture materials. FISH procedures for the detection of Histoplasma capsulatum var. capsulatum have not been reported so far. This study describes the development and evaluation of fluorescently labeled rRNA-targeting FISH probes to detect and identify H. capsulatum in blood cultures. All three analyzed H. capsulatum reference strains and clinical isolates showed positive signals with the newly designed specific oligonucleotide probes for H. capsulatum, whereas negative reactions were observed for all three nontarget yeast species and the two nontarget bacteria. The assay was also successfully applied for detections of H. capsulatum cells in pre-incubated blood culture samples of patients with clinical suspicion of histoplasmosis (n = 33). The described FISH-based assay was shown to be easy to apply, sensitive, and specific (compared to polymerase chain reaction) for the detection and identification of H. capsulatum in this proof-of-principle analysis. Larger multicentric assessments are recommended for a thorough diagnostic evaluation of the procedure. © The Author 2014. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Disseminated primary cutaneous histoplasmosis successfully treated with itraconazole

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Singhi M

2003-11-01

Full Text Available A 60-year-old immunocompetent lady with disseminated primary cutaneous histoplasmosis is reported. Histology showed a granulomatous skin infiltrate with numerous intracellular PAS positive rounded yeast cells within macrophages. Culture on Sabouraud′s dextrose agar yielded a typical cottony white colony characteristic of Histoplasma capsulatum. Treatment with itraconazole showed an excellent response.

Fuentes de infeccion de histoplasmosis en la Isla de la Juventud, Cuba Sources of infection of histoplasmosis in the Island of Youth, Cuba

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Carlos Manuel Fernandez Andreu

1992-10-01

Full Text Available El propósito del presente trabajo es reportar el aislamiento de Histoplasma capsulation, agente etiológico de la histoplasmosis, a partir del suelo de lugares habitados por murciélagos y gallinas en la Isla de la Juventud, Cuba. El hongo fue cultivado también a partir de los órganos de cuatro especies de murciélagos capturados en cuevas. La identificación de H. capsulatum se realizó mediante la conversión de la fase miceliana a levadura y por el test de exoantígenos. Se señala el valor epidemiológico de estos hallazgos en cuevas de gran importancia arqueológica, espeleológica y turística, así como el riesgo potencial que representan para la salud humana. Los autores concluyen con recomendaciones para evitar la infección por H. capsulatum en aquellas personas que por determinadas razones tengan que estar en contacto con estos ambientes contaminados.The purpose of this work is to report the isolation of Histoplasma capsulatum, etiologic agent of histoplasmosis, from soil in sites inhabited by bats and chicken in the Island of Youth, Cuba. The fungus was cultured from four species of cavedwelling bats too. The identification of H. capsulatum was done by mycelial to yeast conversion and exoantigen test. It is pointed out the epidemiological value of some of these isolations in caves of great importance from the archeologic, speleologic or touristic point of view; and the potential risk that they represent to human health. The authors conclude with some recommendation to prevent the infection with H. capsultatum in people who have to keep in contact with those environments.

Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis

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Jessica Lum

2018-01-01

Full Text Available Miliary histoplasmosis is a rare presentation that may mimic miliary tuberculosis. We report a case of miliary histoplasmosis in a 52-year-old male who was being treated with hydroxychloroquine, methotrexate, and sulfasalazine for his rheumatoid arthritis and presented to the emergency department with shortness of breath and fevers. Computed tomography (CT chest revealed miliary pulmonary nodules. Urine Histoplasma antigen and serum Histoplasma antigen were negative; however, Coccidioides immitis complement immunofixation assay and Coccidioides IgM were positive. The patient was initiated on treatment for pulmonary coccidioidomycosis and immunosuppression was held. However, a few days later, Histoplasma capsulatum was isolated from cultures from bronchoscopy. This case highlights the difficulty in diagnosing histoplasmosis in immunocompromised patients and the importance of having a broad differential diagnosis for miliary pulmonary nodules. Tissue culture and histopathology remain the gold standard for the diagnosis of histoplasmosis. Further research needs to be conducted to determine the optimal duration of histoplasmosis treatment in immunocompromised patients.

Associação da rifampicina à anfotericina B no tratamento da paracoccidioidomicose: resultados em três pacientes tratados Association of Amphotericin B and Rifampicin in the treatment of paracoccidioidomycosis. Report of efficacy in three cases

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Bodo Wanke

1984-08-01

Full Text Available Trabalhos experimentais demonstraram que a anfotericina B, desorganizando funcionalmente a membrana celular fúngica, permite a penetração da rifampicina no citoplasma e sua conseqüente ação contra Histoplasma capsulatum, Blastomyces dermatitidis e Candida albicans. Com metade das doses habituais' de anfotericina B associada à rifampicina conseguem-se melhores resultados do que com a anfotericina B isoladamente em doses plenas. Os Autores discutem as possíveis aplicações desta associação no tratamento da paracoccidioidomi-cose e apresentam 3 casos desta micose em que a inatividade clínica e micológica só foi obtida após o emprego combinado destas drogas.Experimental data have shown that low concentration of amphotericin B disrupts of the fungal cellular membranes, enhancing entrance of rifampicin into citoplasm, where it acts specifically as an antifungal agent against Histoplasma capsulatum, Blastomyces dermatitidis and Candida albicans. Amphotericin B in half dosage combined with rifampicin is more effective than when used alone in full dosage. The Authors discuss the possible indications of this association in the therapy of paracoccidioidomycosis, and report its efficacy in three cases of this disease only controlled after its use.

Water reform in the Murray-Darling Basin

Science.gov (United States)

Connell, Daniel; Grafton, R. Quentin

2011-12-01

In Australia's Murray-Darling Basin the Australian and state governments are attempting to introduce a system of water management that will halt ongoing decline in environmental conditions and resource security and provide a robust foundation for managing climate change. This parallels similar efforts being undertaken in regions such as southern Africa, the southern United States, and Spain. Central to the project is the Australian government's Water Act 2007, which requires the preparation of a comprehensive basin plan expected to be finalized in 2011. This paper places recent and expected developments occurring as part of this process in their historical context and examines factors that could affect implementation. Significant challenges to the success of the basin plan include human resource constraints, legislative tensions within the Australian federal system, difficulties in coordinating the network of water-related agencies in the six jurisdictions with responsibilities in the Murray-Darling Basin, and social, economic, and environmental limitations that restrict policy implementation.

Histoplasmosis in Africa: An emerging or a neglected disease?

Science.gov (United States)

2018-01-01

Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952–2017), 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H. capsulatum var. capsulatum (Hcc). There have been 12 histoplasmin skin test surveys with rates of 0% to 35% positivity. Most cases of Hcd presented as localised lesions in immunocompetent persons; however, it was disseminated in AIDS patients. Rapid diagnosis of histoplasmosis in Africa is only currently possible using microscopy; antigen testing and PCR are not available in most of Africa. Treatment requires amphotericin B and itraconazole, both of which are not licensed or available in several parts of Africa. PMID:29346384

Disseminated histoplasmosis simulating miliary tuberculosis: a case report

International Nuclear Information System (INIS)

Tavares Junior, Wilson Campos; Madureira, Marcus Magalhaes; Andrade, Diego Correa de; Guimaraes, Silvana Mangeon Meireles; Queiroz, Leonardo Campos; Avila, Renata Eliane de; Lambertucci, Jose Roberto

2005-01-01

Histoplasmosis is a disease caused by inhalation of the fungus Histoplasma capsulatum. In rare cases the disease affects immunocompetent individuals. Disseminated and severe disease is seen in immunocompromised patients. We report a case of a 45 year old immunocompromised patient presenting with weight loss and abdominal pain. Chest x-ray and computerized tomography examinations showed interstitial infiltrate and diffuse micro nodules. The initial diagnosis was miliary tuberculosis. However, the definitive diagnosis of miliary histoplasmosis was made later on. (author)

Disseminated histoplasmosis simulating miliary tuberculosis: a case report; Histoplasmose disseminada simulando tuberculose miliar: relato de caso

Energy Technology Data Exchange (ETDEWEB)

Tavares Junior, Wilson Campos; Madureira, Marcus Magalhaes; Andrade, Diego Correa de; Guimaraes, Silvana Mangeon Meireles; Queiroz, Leonardo Campos [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Hospital das Clinicas. Dept. de Radiologia e Diagnostico por Imagem]. E-mail: wilsontavaresjrmd@yahoo.fr; Avila, Renata Eliane de [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Hospital das Clinicas. Servico de Doencas Infecciosas e Parasitarias; Lambertucci, Jose Roberto [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Faculdade de Medicina. Clinica Medica

2005-04-15

Histoplasmosis is a disease caused by inhalation of the fungus Histoplasma capsulatum. In rare cases the disease affects immunocompetent individuals. Disseminated and severe disease is seen in immunocompromised patients. We report a case of a 45 year old immunocompromised patient presenting with weight loss and abdominal pain. Chest x-ray and computerized tomography examinations showed interstitial infiltrate and diffuse micro nodules. The initial diagnosis was miliary tuberculosis. However, the definitive diagnosis of miliary histoplasmosis was made later on. (author)

Usefulness of molecular markers in the diagnosis of occupational and recreational histoplasmosis outbreaks.

Science.gov (United States)

Frías-De-León, María Guadalupe; Ramírez-Bárcenas, José Antonio; Rodríguez-Arellanes, Gabriela; Velasco-Castrejón, Oscar; Taylor, Maria Lucia; Reyes-Montes, María Del Rocío

2017-03-01

Histoplasmosis is considered the most important systemic mycosis in Mexico, and its diagnosis requires fast and reliable methodologies. The present study evaluated the usefulness of PCR using Hcp100 and 1281-1283 (220) molecular markers in detecting Histoplasma capsulatum in occupational and recreational outbreaks. Seven clinical serum samples of infected individuals from three different histoplasmosis outbreaks were processed by enzyme-linked immunosorbent assay (ELISA) to titre anti-H. capsulatum antibodies and to extract DNA. Fourteen environmental samples were also processed for H. capsulatum isolation and DNA extraction. Both clinical and environmental DNA samples were analysed by PCR with Hcp100 and 1281-1283 (220) markers. Antibodies to H. capsulatum were detected by ELISA in all serum samples using specific antigens, and in six of these samples, the PCR products of both molecular markers were amplified. Four environmental samples amplified one of the two markers, but only one sample amplified both markers and an isolate of H. capsulatum was cultured from this sample. All PCR products were sequenced, and the sequences for each marker were analysed using the Basic Local Alignment Search Tool (BLASTn), which revealed 95-98 and 98-100 % similarities with the reference sequences deposited in the GenBank for Hcp100 and 1281-1283 (220) , respectively. Both molecular markers proved to be useful in studying histoplasmosis outbreaks because they are matched for pathogen detection in either clinical or environmental samples.

Immune reconstitution syndrome in a human immunodeficiency virus infected child due to giardiasis leading to shock

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Sneha Nandy

2015-01-01

Full Text Available Human immunodeficiency virus (HIV-associated immune reconstitution inflammatory syndrome has been reported in association with tuberculosis, herpes zoster (shingles, Cryptococcus neoformans, Kaposi′s sarcoma, Pneumocystis pneumonia, hepatitis B virus, hepatitis C virus, herpes simplex virus, Histoplasma capsulatum, human papillomavirus, and Cytomegalovirus. However, it has never been documented with giardiasis. We present a 7-year-old HIV infected girl who developed diarrhea and shock following the initiation of antiretroviral therapy, and her stool showed the presence of giardiasis.

Brotes de histoplasmosis registrados en el área andina colombiana

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Nelly Ordóñez

1997-06-01

Full Text Available A review of 12 histoplasmosis outbreaks that occurred in the Colombian Andean region, are presented. According to their location, 3 were detected in each of the following states: Tolima, Caldas and Antioquia and 1 each in Cundinamarca, Boyacá and Risaralda. In 9 of the outbreaks it was possible to trace the following activities which led to the infection: visits to bat-inhabited caves, removing debris incide a hollowed tree, demolition of an old house, use of contaminated lime for fertilization, handling chickenmanure fettilised soil and the severe pruning of coffee trees. Histoplasma capsulatum var. capsulatum was isolated from environmental samples in 5 of the 8 outbreaks where it was feasible to obtain material for culture and animal inoculation. It was found that 332 persons had been in contact with the various infectious sources, including the 11 index cases (2 outbreaks had the same index case. All of them were studied by means of immunological tests designed to detect antibodies; based on the findings of reactive tests, al1 the index cases and 140 (42% of those exposed had antibodies indicative of infection by the fungus. The above cases reveal the importance of histoplasmosis in immunocompetent individuals who, for occupational or recreational reasons, are exposed to infectious aerosols generated when disturbing the natural habitat of H. capsulatum var. capsulatum.

Histoplasmose pulmonar aguda no Rio Grande do Sul Acute pulmonary histoplasmosis in the State of Rio Grande do Sul, Brazil

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Gisela Unis

2005-02-01

Full Text Available INTRODUÇÃO: A histoplasmose pulmonar aguda depende da inalação de uma grande quantidade de propágulos fúngicos por um paciente hígido. O tempo de exposição determina a gravidade da doença. Uma epidemia é influenciada por fatores que afetam o crescimento e a transmissão do Histoplasma capsulatum var. capsulatum na natureza. OBJETIVO: Identificar os aspectos epidemiológicos e clínico-laboratoriais dos pacientes com histoplasmose pulmonar aguda no Rio Grande do Sul e compará-los com as microepidemias relatadas no Brasil. MÉTODO: Foram revisados 212 prontuários clínicos de pacientes com histoplasmose dos arquivos do Laboratório de Micologia do Complexo Hospitalar Santa Casa de Porto Alegre (RS num período de 25 anos (1977-2002. Foram identificados e incluídos no estudo os casos de histoplasmose pulmonar aguda com cultivo positivo e/ou achado histopatológico compatível. As microepidemias foram diagnosticadas com a comprovação de um caso ou evidência soromicológica com história clínica compatível. Foram revisadas as microepidemias publicadas no Brasil. RESULTADOS: Dezoito de um total de 212 pacientes (8,5% foram incluídos no trabalho. A idade variou de 8 a 63 anos (média de 35,4; mediana de 34,5, e 67% eram do sexo masculino. A história epidemiológica foi sugestiva em 11 pacientes (61%. O tipo primário de histoplasmose pulmonar aguda foi o mais freqüente (17; 95%. Houve predomínio de casos isolados. CONCLUSÃO: O reconhecimento de casos isolados e a presença de microepidemias demonstram a abundância do H. capsulatum no solo, e juntamente com a ocorrência de todas as formas da doença, confirmam o Rio Grande do Sul como hiperendêmico para histoplasmose.BACKGROUND: Acute pulmonary histoplasmosis is a respiratory infection occurring when an otherwise healthy individual inhales a large quantity of fungal propagules. Length of exposure determines disease severity. An epidemic is influenced by factors affecting the

Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

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Ana Carolina Alves de Paula e Silva

2014-01-01

Full Text Available This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14 compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.

Disseminated canine histoplasmosis: a clinical survey of 24 cases in Texas.

Science.gov (United States)

Mitchell, M; Stark, D R

1980-03-01

The clinical features of 24 cases of disseminated canine histoplasmosis are presented. The enteric form predominated and the age at presentation was from five months to ten years. The principal clinical findings were chronic diarrhea, weight loss, pyrexia and anemia.A premortem diagnosis was reached in 20 cases, by demonstrating Histoplasma capsulatum organisms in peripheral blood smears, rectal scrapings or surgical biopsies. Five of seven dogs treated with amphotericin B were released in asymptomatic condition. Four of these cases relapsed six to 15 months following therapy. The overall mortality rate was 80%.

Spatio-temporal modelling of rainfall in the Murray-Darling Basin

Science.gov (United States)

Nowak, Gen; Welsh, A. H.; O'Neill, T. J.; Feng, Lingbing

2018-02-01

The Murray-Darling Basin (MDB) is a large geographical region in southeastern Australia that contains many rivers and creeks, including Australia's three longest rivers, the Murray, the Murrumbidgee and the Darling. Understanding rainfall patterns in the MDB is very important due to the significant impact major events such as droughts and floods have on agricultural and resource productivity. We propose a model for modelling a set of monthly rainfall data obtained from stations in the MDB and for producing predictions in both the spatial and temporal dimensions. The model is a hierarchical spatio-temporal model fitted to geographical data that utilises both deterministic and data-derived components. Specifically, rainfall data at a given location are modelled as a linear combination of these deterministic and data-derived components. A key advantage of the model is that it is fitted in a step-by-step fashion, enabling appropriate empirical choices to be made at each step.

[Histoplasmosis - an unusual African souvenir].

Science.gov (United States)

Raselli, C; Reinhart, W H; Fleisch, F

2013-02-01

A 24-year-old woman (student of biology) was part of a study group in Uganda. She developed fever and headache, which was empirically treated as malaria. After she had returned to Switzerland, a chest x-ray showed bilateral miliary nodular infiltrates. In assumption of an atypical pneumonia, she was treated with levofloxacin, although without success. On admission, she was in a bad general condition and was markedly dyspneic. Rales were heard over both lungs. CRP, liver enzymes and LDH were elevated. A lung function test revealed a marked impairment of the diffusion capacity. The chest x-ray showed a progression of the lung infiltrates. The informal medical data exchange among the group members by a virtual social network abbreviated our diagnostic workup substantially, since we heard that histoplasmosis had been assumed in another group member. It turned out that the affected persons had visited a colony of bats living in a cave inside the trunk of a tree. Antibodies against Histoplasma capsulatum were positive. We began a treatment with itraconazole. The condition improved gradually; chest x-ray and lung function normalized after the 8 week treatment. Histoplasmosis with such a severe course is rare in immunocompetent humans, which indicates that the inoculum must have been very high. Soil contaminated with bats guano favours the proliferation of Histoplasma capsulatum. Our case is also an illustration of how the widespread use of electronic media can sometimes facilitate our work. © Georg Thieme Verlag KG Stuttgart · New York.

[Outbreak of histoplasmosis in province of Neuquén, Patagonia Argentina].

Science.gov (United States)

Calanni, Liliana María; Pérez, Rufina Ana; Brasili, Susana; Schmidt, Norma Graciela; Iovannitti, Cristina Adela; Zuiani, María Fernanda; Negroni, Ricardo; Finquelievich, Jorge; Canteros, Cristina Elena

2013-01-01

In Argentina, there are no reports of autochthonous cases of histoplasmosis in the southern regions of the country. To report a histoplasmosis outbreak in Zapala town, Province of Neuquén, Patagonia Argentina. We evaluated the clinical and epidemiological characteristics of 5 patients involved in the outbreak. Environmental studies were conducted to determine the source of infection. The genetic profile of Histoplasma capsulatum strains isolated from the index case (IC) were compared with clinical isolates from Argentinean patients not related to the outbreak, using RAPD-PCR with primers 1281-1283. The patients were residents of Zapala, and had not visited other geographical areas before. All patients had an influenza-like syndrome, and X-ray revealed disseminated micronodular images throughout the lung parenchyma. The IC needed specific antifungal therapy; the remaining 4 patients had mild symptoms, and did not require therapy. All of them had a good clinical outcome. Strains of H. capsulatum isolated from blood culture and lung biopsy of the IC showed a genetic profile different from other strains analyzed. The presence of the fungus in the environment was demonstrated by the detection of anti-Histoplasma antibodies in BALB/c mice inoculated with soil obtained in a culvert where workers had dug up earth after a landslide. This outbreak suggests the histoplasmosis endemic area is under the 38° S parallel. Patients from Neuquén, Patagonia Argentina, with compatible symptoms of histoplasmosis should be tested, regardless of their travel or exposure history. Copyright © 2012 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Diversity for sustainability: learning from the Murray-darling basin experience

International Nuclear Information System (INIS)

Syed, J.

2005-01-01

This paper investigates the inter-link between cultural diversity and biodiversity in the Indus basin in Pakistan with an aim to explore its impact on the environmental sustainability. I argue that culture is an important intermediary between behavior and environment, influencing social participation and environmental action and consequently sustainable development. Thus a better understanding of the interdependence between cultural and biological diversity is an essential prerequisite for the effective protection of both (people and environment). refer to and describe the Murray-Darling Basin Commission in Australia as a useful model for environmental sustainability. I argue that the Murray-Darling Basin Commission's model is useful due to: its focus on indigenous life as much as formal education, its involvement in multi-modal environmental literacies, and its emphasis on process and participation resulting in improved activity and ownership in the local communities. Within this context, I identify a number of issues as important for sustainability of the riverine environment in the Indus basin. I propose that the implementation of this model will result in increased awareness and dynamism vital for the environmental sustainability in the Indus basin. (author)

Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi

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Raimunda Sâmia Nogueira Brilhante

Full Text Available Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22 and Histoplasma capsulatum in both filamentous (n = 40 and yeast phases (n = 13, using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC and minimum fungicidal concentration (MFC of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720 µg/mL, 20-2860 µg/mL, and 40-1420 µg/mL, respectively for terpinen-4-ol; 250-4000 µg/mL, 30-2000 µg/mL, and 10-1000 µg/mL, respectively, for tyrosol; and 0.48-7.8 µg/mL, 0.25-16 µg/mL, and 0.125-4 µg/mL, respectively for β-lapachone. These compounds showed a decrease in MIC when the samples were subjected to osmotic stress, suggesting that the compounds acted on the fungal membrane. All the compounds were able to reduce the ergosterol content of the fungal strains. Finally, tyrosol was able to cause a leakage of intracellular molecules.

Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host.

Science.gov (United States)

Boyce, Kylie J; Andrianopoulos, Alex

2015-11-01

The ability of pathogenic fungi to switch between a multicellular hyphal and unicellular yeast growth form is a tightly regulated process known as dimorphic switching. Dimorphic switching requires the fungus to sense and respond to the host environment and is essential for pathogenicity. This review will focus on the role of dimorphism in fungi commonly called thermally dimorphic fungi, which switch to a yeast growth form during infection. This group of phylogenetically diverse ascomycetes includes Talaromyces marneffei (recently renamed from Penicillium marneffei), Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis), Coccidioides species (C. immitis and C. posadasii), Histoplasma capsulatum (teleomorph Ajellomyces capsulatum), Paracoccidioides species (P. brasiliensis and P. lutzii) and Sporothrix schenckii (teleomorph Ophiostoma schenckii). This review will explore both the signalling pathways regulating the morphological transition and the transcriptional responses necessary for intracellular growth. The physiological requirements of yeast cells during infection will also be discussed, highlighting recent advances in the understanding of the role of iron and calcium acquisition during infection. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2-/- mice.

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Verma, A H; Bueter, C L; Rothenberg, M E; Deepe, G S

2017-01-01

Eosinophils contribute to type II immune responses in helminth infections and allergic diseases; however, their influence on intracellular pathogens is less clear. We previously reported that CCR2 -/- mice exposed to the intracellular fungal pathogen Histoplasma capsulatum exhibit dampened immunity caused by an early exaggerated interleukin (IL)-4 response. We sought to identify the cellular source promulgating IL-4 in infected mutant animals. Eosinophils were the principal instigators of non-protective IL-4 and depleting this granulocyte population improved fungal clearance in CCR2 -/- animals. The deleterious impact of eosinophilia on mycosis was also recapitulated in transgenic animals overexpressing eosinophils. Mechanistic examination of IL-4 induction revealed that phagocytosis of H. capsulatum via the pattern recognition receptor complement receptor (CR) 3 triggered the heightened IL-4 response in murine eosinophils. This phenomenon was conserved in human eosinophils; exposure of cells to the fungal pathogen elicited a robust IL-4 response. Thus, our findings elucidate a detrimental attribute of eosinophil biology in fungal infections that could potentially trigger a collapse in host defenses by instigating type II immunity.

Eosinophils Subvert Host Resistance to an Intracellular Pathogen by Instigating Non-Protective IL-4 in CCR2−/− Mice

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Verma, Akash H.; Bueter, Chelsea L.; Rothenberg, Marc E.; Deepe, George S.

2016-01-01

Eosinophils contribute to type II immune responses in helminth infections and allergic diseases, however, their influence on intracellular pathogens is less clear. We previously reported that CCR2−/− mice exposed to the intracellular fungal pathogen Histoplasma capsulatum exhibit dampened immunity caused by an early exaggerated IL-4 response. We sought to identify the cellular source promulgating interleukin (IL)-4 in infected mutant animals. Eosinophils were the principal instigators of non-protective IL-4 and depleting this granulocyte population improved fungal clearance in CCR2−/− animals. The deleterious impact of eosinophilia on mycosis was also recapitulated in transgenic animals overexpressing eosinophils. Mechanistic examination of IL-4 induction revealed that phagocytosis of H. capsulatum via the pattern recognition receptor complement receptor (CR) 3 triggered the heightened IL-4 response in murine eosinophils. This phenomenon was conserved in human eosinophils; exposure of cells to the fungal pathogen elicited a robust IL-4 response. Thus, our findings elucidate a detrimental attribute of eosinophil biology in fungal infections that could potentially trigger a collapse in host defenses by instigating type II immunity. PMID:27049063

Laboratory and clinical assessment of ketoconazole in deep-seated mycoses.

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Drouhet, E; Dupont, B

1983-01-24

Forty-eight cases of deep mycoses were studied and treated with ketoconazole, each with in vitro evaluation of the minimum inhibitory concentrations (MIC) of the causative fungi, in vivo pharmacokinetic, clinical, and mycologic evaluations, several months to two years after the treatment was stopped. Excellent results were obtained in six cases of chronic mucocutaneous candidiasis, with restoration of immunologic disturbances; 23 cases of systemic candidiasis, including new aspects of heroin addicts with cutaneous, ocular, or osteoarticular manifestations; eight cases of histoplasmosis, five due to Histoplasma capsulatum and three to Histoplasma duboisii, with cure in seven and remission in one; one case of African blastomycosis (Blastomyces dermatitidis); three cases of mycetoma, two due to Monosporium apiospermum, one due to a dematiacious fungus; three cases of entomophthoromycosis with cure; one case of fungal arthritis, due to new hyphomycete similar to M. apiospermum, pathogenic for laboratory animals; one case of Drechslera longirostrata causing vertebral arthritis, following a fungal endocarditis and cured by combination of ketoconazole with amphotericin B, each agent alone being ineffective; and other deep mycoses.

Fibrosing mediastinitis and thrombosis of superior vena cava associated with Behcet's disease

International Nuclear Information System (INIS)

Harman, Mustafa; Sayarlioglu, Mehmet; Arslan, Halil; Ayakta, Hayati; Harman, Ece

2003-01-01

We present CT, MRI and venography findings in 13-year boy with mediastinal fibrosis and superior vena cava (SVC) thrombosis associated with Behcet's disease. Fibrosing mediastinitis is an excessive fibrotic reaction that occurs in the mediastinum and may lead to compression of mediastinal structures (especially vascular). This condition is usually idiopathic, though many (and perhaps most) cases in the USA are thought to be caused by an abnormal immunologic response to Histoplasma capsulatum infection. SVC syndrome secondary to extrinsic compression by mediastinal fibrosis combined with Behcet's disease has rarely been described. Radiological investigations of this syndrome are necessary to avoid a useless anticoagulant therapy

Capítulo 4: histoplasmose Chapter 4: histoplasmosis

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Miguel Abidon Aidé

2009-11-01

Full Text Available Histoplasmose é uma micose sistêmica causada por um pequeno fungo, Histoplasma capsulatum var. capsulatum, cujo habitat é o solo rico em excrementos de pássaros e morcegos. A incidência da histoplasmose é mundial. No Brasil, a doença incide em todas as regiões; porém, o estado do Rio de Janeiro é responsável pelo maior número de microepidemias descritas até hoje. A infecção humana ocorre pela inalação de esporos do H. capsulatum. A forma clínica mais freqüente é a assintomática. Na histoplasmose aguda ou epidêmica, os sintomas são febre alta, tosse, astenia, dor retroesternal, acompanhados de aumento dos linfonodos cervicais, fígado e do baço. Os achados radiológicos mais frequentes são o infiltrado reticulonodular difuso em ambos os pulmões, associados a linfonodomegalias hílares e mediastinais. Na forma pulmonar crônica, o quadro clínico e radiológico é idêntico ao da tuberculose pulmonar do adulto. O diagnóstico da histoplasmose é feito pela identificação do fungo ou crescimento em cultura de escarro ou de material obtido por fibrobroncoscopia. A histopatologia identifica o fungo dentro e fora do macrófago em meio à lesão granulomatosa com ou sem necrose caseosa. A imunodifusão em duplo gel de ágar é o teste sorológico mais fácil e disponível para o diagnóstico imunológico. As formas agudas com sintomas prolongados, as formas disseminadas e a forma pulmonar crônica requerem tratamento. A droga de escolha é o itraconazol.Histoplasmosis is systemic mycosis caused by a small fungus, Histoplasma capsulatum var. capsulatum, whose natural habitat is soil contaminated by bat or bird excrement. The incidence of histoplasmosis is worldwide. In Brazil, the disease is found in all regions; however, the state of Rio de Janeiro is responsible for most of the microepidemics described. Human infection occurs when airborne spores of H. capsulatum are inhaled. The most common clinical presentation is

Education, Place and Sustainability: A Literature Review and Overview of Curriculum and Policy in the States and the Territory of the Murray-Darling Basin

Science.gov (United States)

Roberts, Philip; Downes, Natalie; Cook, Louise; Heiner, Irmgard; Caffery, Jo

2014-01-01

This report has been developed as part of the MDBfutures Collaborative Research Network project "Towards Place Based Education in the Murray-Darling Basin." The project explores the ways in which sustainability is understood in Murray Darling Basin (MDB) communities of Australia (including Indigenous, rural, small towns and regional…

Criteria for first- and second-order vibrational resonances and correct evaluation of the Darling-Dennison resonance coefficients using the canonical Van Vleck perturbation theory

International Nuclear Information System (INIS)

Krasnoshchekov, Sergey V.; Isayeva, Elena V.; Stepanov, Nikolay F.

2014-01-01

The second-order vibrational Hamiltonian of a semi-rigid polyatomic molecule when resonances are present can be reduced to a quasi-diagonal form using second-order vibrational perturbation theory. Obtaining exact vibrational energy levels requires subsequent numerical diagonalization of the Hamiltonian matrix including the first- and second-order resonance coupling coefficients. While the first-order Fermi resonance constants can be easily calculated, the evaluation of the second-order Darling-Dennison constants requires more complicated algebra for seven individual cases with different numbers of creation-annihilation vibrational quanta. The difficulty in precise evaluation of the Darling-Dennison coefficients is associated with the previously unrecognized interference with simultaneously present Fermi resonances that affect the form of the canonically transformed Hamiltonian. For the first time, we have presented the correct form of the general expression for the evaluation of the Darling-Dennison constants that accounts for the underlying effect of Fermi resonances. The physically meaningful criteria for selecting both Fermi and Darling-Dennison resonances are discussed and illustrated using numerical examples

Bacterial and fungal flora of seagull droppings in Jersey

Science.gov (United States)

Cragg, John; Clayton, Yvonne M.

1971-01-01

In Jersey 166 fresh and 122 dried seagull droppings were obtained and studied locally and in London for the presence of bacteria and fungi of potentially pathogenic nature. There were no salmonella or shigella bacteria isolated from the two groups but there was a high proportion of Candida albicans obtained from the fresh material (21·7%) and only 1·6% from the dry faeces. Cryptococcus neoformans and Histoplasma capsulatum were not found in either the dry or fresh droppings. The normal bacterial and fungal flora of the seagull was established and it is considered that the C. albicans in fresh gull droppings would not materially increase albicans infections in man. PMID:5104846

Chronicle pulmonary histoplasmosis

International Nuclear Information System (INIS)

Llanos, Elkin; Ojeda, Paulina

2004-01-01

Histoplasmosis is an acquired mycotic disease produced by the histoplasma capsulatum very frequent in Colombia, primarily affecting lungs. The pathogenesis of the histoplasmosis is similar to the one of tuberculosis. From the clinical point of view, this disease has several manifestations including the primary acute and chronic pulmonary forms. Histoplasmoma pulmonary disseminated histoplasmosis, mediastinal compromise due to granulomatosis and fibrosis, as well as ocular histoplasmosis. A clinical case of a 33-year old man is presented who consults for dry coughing of one year of evolution, without any other symptomatology, with a normal chest x-ray and after several studies including chest cat and fiber-bronchoscopy. A pulmonary histoplasmosis was determined by histopathology

The Leukotriene B4/BLT1 Axis Is a Key Determinant in Susceptibility and Resistance to Histoplasmosis

Science.gov (United States)

Secatto, Adriana; Soares, Elyara Maria; Locachevic, Gisele Aparecida; Assis, Patricia Aparecida; Paula-Silva, Francisco Wanderlei Garcia; Serezani, Carlos Henrique; de Medeiros, Alexandra Ivo; Faccioli, Lúcia Helena

2014-01-01

The bioactive lipid mediator leukotriene B4 (LTB4) greatly enhances phagocyte antimicrobial functions against a myriad of pathogens. In murine histoplasmosis, inhibition of the LT-generating enzyme 5-lypoxigenase (5-LO) increases the susceptibility of the host to infection. In this study, we investigated whether murine resistance or susceptibility to Histoplasma capsulatum infection is associated with leukotriene production and an enhancement of in vivo and/or in vitro antimicrobial effector function. We show that susceptible C57BL/6 mice exhibit a higher fungal burden in the lung and spleen, increased mortality, lower expression levels of 5-LO and leukotriene B4 receptor 1 (BLT1) and decreased LTB4 production compared to the resistant 129/Sv mice. Moreover, we demonstrate that endogenous and exogenous LTs are required for the optimal phagocytosis of H. capsulatum by macrophages from both murine strains, although C57BL/6 macrophages are more sensitive to the effects of LTB4 than 129/Sv macrophages. Therefore, our results provide novel evidence that LTB4 production and BLT1 signaling are required for a histoplasmosis-resistant phenotype. PMID:24465479

Effects of sediment quality on macroinvertebrates in the Sunraysia region of the Murray-Darling Rivers, Australia

Energy Technology Data Exchange (ETDEWEB)

Sharley, David J. [Centre for Environmental Stress and Adaptation Research-Hoffmann Laboratory, Zoology Department, University of Melbourne, Level 2, Bio 21 Institute, 30 Flemington Road, Parkville, Victoria 3010 (Australia)], E-mail: sharleyd@unimelb.edu.au; Hoffmann, Ary A. [Centre for Environmental Stress and Adaptation Research-Hoffmann Laboratory, Zoology Department, University of Melbourne, Level 2, Bio 21 Institute, 30 Flemington Road, Parkville, Victoria 3010 (Australia); Pettigrove, Vincent [Research and Technology, Melbourne Water, PO Box 4342, Melbourne, Victoria 3001 (Australia)

2008-12-15

A field-based microcosm approach was tested to identify deterioration of sediment quality in waterways using freshwater macroinvertebrates. The method can potentially identify the nature of contaminants based on species-specific responses. Sediments were collected from the Murray and Darling Rivers and irrigation drains within the Sunraysia region of south-eastern Australia and compared to non-polluted reference sediment. Clean sediments were also spiked with fertiliser to test whether nutrients affected the aquatic fauna. Seven of the eight sediments from the Sunraysia region had a negative impact on the macroinvertebrates, in particular sediment from the Darling River, which supported an impoverished fauna. Three species of chironomid showed varied responses to sediment quality and, although it was hypothesised that nutrients may have impacted on the macroinvertebrate fauna, the results suggest that other pollutants are also involved. The field-based microcosm method proved effective for determining the impact of sediment quality on indigenous macroinvertebrates. - Sediment quality effects on freshwater macroinvertebrates are isolated.

Effects of sediment quality on macroinvertebrates in the Sunraysia region of the Murray-Darling Rivers, Australia

International Nuclear Information System (INIS)

Sharley, David J.; Hoffmann, Ary A.; Pettigrove, Vincent

2008-01-01

A field-based microcosm approach was tested to identify deterioration of sediment quality in waterways using freshwater macroinvertebrates. The method can potentially identify the nature of contaminants based on species-specific responses. Sediments were collected from the Murray and Darling Rivers and irrigation drains within the Sunraysia region of south-eastern Australia and compared to non-polluted reference sediment. Clean sediments were also spiked with fertiliser to test whether nutrients affected the aquatic fauna. Seven of the eight sediments from the Sunraysia region had a negative impact on the macroinvertebrates, in particular sediment from the Darling River, which supported an impoverished fauna. Three species of chironomid showed varied responses to sediment quality and, although it was hypothesised that nutrients may have impacted on the macroinvertebrate fauna, the results suggest that other pollutants are also involved. The field-based microcosm method proved effective for determining the impact of sediment quality on indigenous macroinvertebrates. - Sediment quality effects on freshwater macroinvertebrates are isolated

Comparison of the lysis-centrifugation and agitated biphasic blood culture systems for detection of fungemia.

Science.gov (United States)

Murray, P R

1991-01-01

Although the detection of fungemia has been improved by the use of vented or biphasic blood culture bottles, the best recovery and earliest detection have been reported in the Isolator lysis-centrifugation system. It was recently demonstrated that improved detection of both bacteria and fungi was accomplished by mechanically agitating blood culture bottles for the first 24 h of incubation. In this study the detection of fungemia by use of the Isolator system was compared with that of an agitated biphasic system. A total of 182 fungi were isolated from blood specimens inoculated into both culture systems. No difference in the overall recovery of fungi or individual species of yeasts was observed between the two systems. However, all seven isolates of Histoplasma capsulatum were recovered in the Isolator system only. The time required to detect fungemia with each of the two systems was also compared. No statistically significant difference was observed. From the data collected during this 18-month study, it can be concluded that the overall recovery and time of detection of yeasts are equivalent in the lysis-centrifugation system and the agitated biphasic blood culture system. The lysis-centrifugation system is still superior for the detection of filamentous fungi such as H. capsulatum. PMID:1993772

Histoplasmosis diseminada, linfopenia, y síndrome de Sjögren

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Horacio F. Rodrigo

2012-10-01

Full Text Available El síndrome de Sjögren es una enfermedad autoinmune caracterizada por disminución de las secreciones de las glándulas exocrinas; puede presentar también diversas alteraciones hemáticas, entre ellas linfopenia. Presentamos el caso de un varón de 28 años que consultó por cefalea de un mes de evolución a la que se agregaron en las últimas 48 horas vómitos y fiebre. Presentaba lesiones en piel de tronco y cara; no tenía rigidez de nuca. Se demostró infección por Histoplasma capsulatum var. capsulatum en piel y líquido cefalorraquídeo, linfopenia, anticuerpos anti Ro-SSA positivos, baja concentración del trazador en centellograma de glándulas salivales e infiltración linfocitaria en glándulas salivales, lo que permitió confirmar al diagnóstico de síndrome de Sjögren. El tratamiento con anfotericina liposomal e itraconazol mejoró el cuadro clínico. Comunicamos este caso para referir que una infección oportunista, como la histoplasmosis diseminada, puede ser una forma poco común de presentación del síndrome de Sjögren.

Pulmonary histoplasmosis presenting as chronic productive cough, fever, and massive unilateral consolidation in a 15-year-old immune-competent boy: a case report

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Mshana Stephen E

2011-08-01

Full Text Available Abstract Introduction Severe histoplasmosis is known to be among the AIDS-defining opportunistic infections affecting patients with very low CD4 cell counts in histoplasmosis-endemic areas. Histoplasma capsulatum var. duboisii is common in West and Central Africa, where it occurs in both HIV/AIDS and non-HIV patients. Few cases of life-threatening histoplasmosis in immune-competent individuals have been reported worldwide. Case report We describe a case of pulmonary histoplasmosis diagnosed on the basis of autopsy and histological investigations. A 15-year old East African immune-competent boy with a history of smear-positive tuberculosis and a two-year history of rock cutting presented to our hospital with chronic productive cough, fever, and massive unilateral consolidation. At the time of presentation to our hospital, this patient was empirically treated for recurrent tuberculosis without success, and he died on the seventh day after admission. The autopsy revealed a huge granulomatous lesion with caseation, but no acid-fast bacilli were detected on several Ziehl-Neelsen stains. However, periodic acid-Schiff staining was positive, and the histological examination revealed features suggestive of Histoplasma yeast cells. Conclusion Severe pulmonary histoplasmosis should be considered in evaluating immune-competent patients with risk factors for the disease who present with pulmonary symptoms mimicking tuberculosis.

Integrative Governance of Environmental Water in Australia's Murray-Darling Basin: Evolving Challenges and Emerging Pathways.

Science.gov (United States)

Bischoff-Mattson, Zachary; Lynch, Amanda H

2017-07-01

Integration, a widely promoted response to the multi-scale complexities of social-environmental sustainability, is diversely and sometimes poorly conceptualized. In this paper we explore integrative governance, which we define as an iterative and contextual process for negotiating and advancing the common interest. We ground this definition in a discussion of institutional factors conditioning integrative governance of environmental water in Australia's Murray-Darling Basin. The Murray-Darling Basin is an iconic system of social-ecological complexity, evocative of large-scale conservation challenges in other developed arid river basins. Our critical assessment of integrative governance practices in that context emerges through analysis of interviews with policy participants and documents pertaining to environmental water management in the tri-state area of southwestern New South Wales, northwestern Victoria, and the South Australian Riverland. We identify four linked challenges: (i) decision support for developing socially robust environmental water management goals, (ii) resource constraints on adaptive practice, (iii) inter-state differences in participatory decision-making and devolution of authority, and (iv) representative inclusion in decision-making. Our appraisal demonstrates these as pivotal challenges for integrative governance in the common interest. We conclude by offering a perspective on the potential for supporting integrative governance through the bridging capacity of Australia's Commonwealth Environmental Water Holder.

Disseminated Infection by Mycobacterium sherrisii and Histoplasma capsulatum in an African HIV-Infected Patient

Science.gov (United States)

Taján, Juan; Espasa, Mateu; Sala, Montserrat; Navarro, Marta; Font, Bernat; González-Martín, Julián; Segura, Ferran

2013-01-01

Mycobacterium sherrisii is a new species of opportunistic, slow-growing, non-tuberculous Mycobacterium closely related to Mycobacterium simiae that can currently be identified with the sequence of 16S rARN gene and the heat-shock protein 65. Few cases of patients infected by this Mycobacterium have been reported and all of them were associated with human immunodeficiency virus or other immunosuppressive conditions. Clinical management is complex, because there is not a clear correlation between the in vitro antibiotic susceptibility testing and the patient's clinical outcome. PMID:23419367

Brote de histoplasmosis aguda en un grupo familiar: identificación de la fuente de infección

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Roberto Alonso Jiménez

2002-06-01

Full Text Available Se informa un brote de histoplasmosis ocurrido en los integrantes de una familia y que comprometió a cuatro personas, dos mujeres, una niña y un hombre. El caso índice consultó por sintomatología respiratoria grave, de comienzo súbito, que requirió hospitalización. En los otros casos, la infección cursó de manera asintomática pero se puso en evidencia por la reactividad en las pruebas serológicas con histoplasmina. La búsqueda de una fuente común de contagio llevó a sospechar que era la tierra de un vivero que se había utilizado como fertilizante de las plantas caseras. Las suspensiones de las tierras de las macetas sirvieron para inocular ratones BALB/c, de cuyos órganos fue posible aislar el agente etiológico, Histoplasma capsulatum var. capsulatum. Si bien la histoplasmosis es más frecuente en ciertas ocupaciones y es propia de áreas rurales, las epidemias y los brotes son ahora comunes en áreas urbanas debido a actividades como la urbanización masiva, la tala de árboles, las demoliciones y el uso de tierras enriquecidas con abonos orgánicos (gallinaza, guano. Se llama la atención sobre el peligro que representa esta última actividad.

Diagnóstico de micosis oportunistas en pacientes con VIH/sida: un estudio de casos en Colombia Diagnosis of fungal opportunistic infections in HIV/AIDS patients: A cases study in Colombia

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Miguel Ángel Castro-Jiménez

2011-06-01

Full Text Available Objetivos. Identificar las micosis oportunistas que afectan a los pacientes con VIH/sida, y determinar sus características demográficas, socioeconómicas y su relación con el número de células T CD4+. Métodos. Se trata de un estudio descriptivo de serie de casos basado en los participantes de un estudio diseñado para determinar el tipo y la frecuencia de las enfermedades oportunistas en pacientes con VIH/sida. Un caso se definió como un paciente con VIH/sida a quien se le diagnosticó una micosis oportunista, entre octubre de 2007 y mayo de 2010. Los pacientes elegibles estaban siendo tratados en dos instituciones médicas de Bogotá. Se recolectaron muestras respiratorias, de líquido cefalorraquídeo, de sangre y de raspado de lesión orofaríngea, para determinar la presencia de Histoplasma capsulatum, Paracoccidioides brasiliensis, Cryptococcus neoformans o Candida spp. Se utilizaron proporciones para resumir las variables cualitativas y medianas para las cuantitativas. Resultados. En 33 (9,8 % pacientes con VIH/sida del estudio base (n=336, se diagnosticó una o más de las micosis evaluadas. El 75 % tenía entre 23 y 42 años. La frecuencia de estas infecciones fueron: H. capsulatum (n=1; 3,0 %, P. brasiliensis (n=1; 3,0 %, C. neoformans (n=25; 75,8 %, y Cándida spp. (n=7; 21,2 %. Los valores medianos de células T CD4+ fueron de 176 o menos, independientemente de sus manifestaciones clínicas. Conclusión. Se necesitan estudios adicionales para identificar los factores que podrían estar determinando la presencia de las micosis oportunistas en estos pacientes.Objectives: To identify the opportunistic fungal infections affecting patients with HIV/AIDS, to determine their demographic and socioeconomic characteristics and the number of CD4+ T cells. Materials and methods: This is a descriptive case series study based on a major study aimed at determining the type and frequency of opportunistic diseases in HIV/AIDS patients. A case

Frecuencia de micosis en pacientes inmunosuprimidos de un hospital regional de la Ciudad de México Frequency of mycoses in immunosuppressed patients in a regional hospital in Mexico City

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Francisca Hernández-Hernández

2003-12-01

Full Text Available OBJETIVO: Aislar e identificar hongos en diferentes especímenes de pacientes inmunocomprometidos, atendidos en un hospital de la Ciudad de México, y determinar su asociación con micosis. MATERIAL Y MÉTODOS: Se realizó un estudio de tipo observacional transversal en pacientes del Hospital Regional General Ignacio Zaragoza, de junio de 1999 a mayo de 2000. De 108 pacientes se procesaron 268 especímenes para estudio micológico que incluyó examen directo, frotis, cultivos y microcultivos en medios específicos además de pruebas bioquímicas. La mayoría de pacientes tenía diagnóstico clínico de tuberculosis pulmonar y de síndrome de inmunodeficiencia adquirida. RESULTADOS: Se obtuvieron 183 aislamientos de levaduras y 66 de hongos filamentosos. Se diagnosticaron 45 micosis que en su mayoría correspondieron a candidosis pulmonar (32 casos. Las especies de Candida más frecuentes asociadas a patología fueron Candida albicans y C parapsilosis. Se obtuvieron cinco aislamientos de Cryptococcus neoformans variedad neoformans, uno de C albidus, tres de Histoplasma capsulatum y uno de Geotrichum candidum, asociados a infección micótica. CONCLUSIONES: El 41.6% de los pacientes estudiados presentaron una micosis asociada principalmente a síndrome de inmunodeficiencia adquirida y a tuberculosis pulmonar.OBJECTIVE: To isolate and identify the fungi in specimens collected from immunocompromised patients seen in Mexico City hospital, and to assess their association with mycosis. MATERIAL AND METHODS: A total of 268 specimens from 108 patients were processed for mycological study, including direct examination, smears, cultures, and microcultures in specific media, in addition to biochemical tests. Most of the patients had been diagnosed with pulmonary tuberculosis and Acquired Immunodeficiency Syndrome (AIDS. RESULTS: One hundred and eighty-three yeasts and 66 mycelial fungi were isolated. Forty-five mycoses were diagnosed; the most frequent

B-cell lymphoma in a dog with ehrlichiosis (Ehrlichia canis) and systemic histoplasmosis (Histoplasma capsulatum).

Science.gov (United States)

Brunker, Jill D; Hoover, John P

2007-03-01

A mixed breed dog treated for ehrlichiosis and systemic histoplasmosis developed a refractory thrombocytopenia. When an abdominal mass was detected, exploratory laparotomy and biopsies confirmed lymphoma, which on immunohistochemical stains was determined to be of B-cell origin. Conceivably, the B-cell lymphoma in this dog was associated with chronic inflammation from ehrlichiosis, histoplasmosis, or both.

Imaging spectrum in disseminated histoplasmosis: case report and brief review

International Nuclear Information System (INIS)

Grover, S.B.; Midha, N.; Gupta, M.; Sharma, U.; Talib, V.H.

2005-01-01

The clinical manifestations of chronic disseminated histoplasmosis are non-specific and resemble those of other chronic infections and malignancies. We report the radiographic, sonographic and contrast-enhanced CT appearances of histoplasmosis in an adult male with non-insulin dependent diabetes mellitus, who was HIV negative and presented with weight loss and pyrexia. Imaging studies simulated tuberculosis with mediastinal lymphadenopathy, bilateral fibrotic lung lesions, hepatomegaly and bilateral hypoattenuating adrenal enlargement, without clinical or laboratory evidence of hypoadrenalism. Computed tomography-guided fine-needle aspiration biopsy of adrenal glands revealed Histoplasma capsulatum. We report our experience to increase awareness of the imaging spectrum of disseminated histoplasmosis and its similarity to tuberculosis as, with increasing incidence of AIDS, the chances of these infections are likely to increase. Moreover, awareness of this entity is important because it is known that untreated disseminated histoplasmosis is fatal Copyright (2005) Blackwell Publishing Asia Pty Ltd

Virulence Factors IN Fungi OF Systemic Mycoses

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KUROKAWA Cilmery Suemi

1998-01-01

Full Text Available Pathogenic fungi that cause systemic mycoses retain several factors which allow their growth in adverse conditions provided by the host, leading to the establishment of the parasitic relationship and contributing to disease development. These factors are known as virulence factors which favor the infection process and the pathogenesis of the mycoses. The present study evaluates the virulence factors of pathogenic fungi such as Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum and Paracoccidioides brasiliensis in terms of thermotolerance, dimorphism, capsule or cell wall components as well as enzyme production. Virulence factors favor fungal adhesion, colonization, dissemination and the ability to survive in hostile environments and elude the immune response mechanisms of the host. Both the virulence factors presented by different fungi and the defense mechanisms provided by the host require action and interaction of complex processes whose knowledge allows a better understanding of the pathogenesis of systemic mycoses.

Diagnóstico molecular de histoplasmosis humana en muestras de sangre entera Molecular diagnosis of human histoplasmosis in whole blood samples

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A. I. Toranzo

2009-03-01

Full Text Available Se evaluó el uso de sangre entera para el diagnóstico molecular de histoplasmosis utilizando un método artesanal de extracción de ADN fúngico y una PCR anidada que amplifica una porción del gen HcP100 específica de Histoplasma capsulatum. La sangre entera se trató con liticasa, enzima lisante de Trichoderma harzianum y proteinasa K, seguido de una extracción fenólica. Este tratamiento permitió una lisis completa de las células, mostró buen rendimiento en la obtención de ADN y posibilitó la detección de la banda de 210 pb específica de H. capsulatum en la PCR anidada. El límite de detección fue de 0,25-1 levaduras/ml de sangre. El método se evaluó en 31 muestras de sangre de 19 pacientes con diagnóstico microbiológico de histoplasmosis, en 21 muestras de pacientes con otras micosis o infecciones por micobacterias y en 30 controles sanos. La PCR fue positiva en sangre para 17/19 pacientes con histoplasmosis (14/15 inmunocomprometidos y 3/4 sin inmunocompromiso aparente. Las muestras de sangre de los 30 controles sanos y de 20 pacientes con otras patologías fueron negativas, sólo hubo un falso positivo correspondiente a un paciente con infección por Mycobacterium avium-intracellulare. El método presentó 89% de sensibilidad y 96% de especificidad para el diagnóstico de histoplasmosis en sangre entera.To assess the value of using whole blood samples for the molecular diagnosis of histoplasmosis, we applied an in-house DNA extraction method and a nested PCR targeting a 210 bp specific segment of the Histoplasma capsulatum HcP100 gene. A whole blood volume of 2.5-3 milliliters was centrifuged and the cellular pellet was treated with Trichoderma harzianum lyticase and proteinase K prior to applying a conventional phenol DNA extraction. This procedure allowed complete cell lysis, high DNA yield and specific amplification. The PCR detection limit was 0.25-1 yeast cells/ml of blood sample. The method was assessed on 31 blood

Forage Options for Dairy Farms with Reduced Water Availability in the Southern Murray Darling Basin of Australia

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Mary-Jane Rogers

2017-12-01

Full Text Available The dairy industry in the southern Murray Darling Basin region of Australia is a major consumer of irrigation water because rainfall is low relative to evapotranspiration and the industrys relies heavily on irrigated temperate pastures and fodder crops. Water reforms, and potential climate change scenarios for this region suggest that there will be an overall decline in rainfall and water available for irrigation in the future. For the irrigated dairy industry to remain economically viable, there is a need for dairy farmers to improve the water productivity (WP of their forage systems and to be able to respond to year-to-year, and within year, variation in water availability. Researchers and dairy farmers are evaluating strategies to increase WP. These include: (i selecting better-adapted species for current and predicted climatic conditions; (ii using species that can survive and still be productive under reduced irrigation and then recover when full irrigation is restored; (iii modifying irrigation strategies to reduce water use whilst maintaining WP; and (iv grazing management strategies that facilitate the survival during, and recovery after, periods of moisture stress. This review will examine these strategies and discusses their potential to optimise forage production from irrigation water inputs so that the dairy industry in the southern Murray Darling Basin remains viable in the future.

Case reports 1964 - pathology. Histoplasmosis of the kidney

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Will, D W; Hasegawa, C M; Kawauchi, Tadanaga; Murashima, Shoichi

1964-07-16

A case is presented of isolated renal histoplasmosis in a Nagasaki woman who died of pulmonary tuberculosis following massive x-ray therapy for squamous carcinoma of the mouth. No primary pulmonary lesion was identified. While the patient's history includes a 40-year residence in Malaysia and a brief internment in New Delhi where a few cases of histoplasmosis have been reported, she had been in Japan for 16 years prior to her death. In view of the presently-known absence of viability of Histoplasma in old primary foci, it was concluded that the infection was acquired in Japan and represents the first case of Histoplasma capsulatum infection reported from Japan (37 references, 5 figures). A second case is presented of a 15-year-old Japanese girl with a clinical history and postmortem findings of a subacute necrotizing encephalomyelopathy is reported. The patient's parents were consanguinous and a similar disease was also present in one sibling. This case and those available in the literature indicate that a severe peripheral neuropathy associated frequently with secondary degeneration of the dorsal white columns of the spinal cord constitutes an integral part of the disorder. The presence of peripheral neuropathy reminiscent of that due to deficiency of thiamine and pantothenic acid, frequent familial occurrence of the disorder and consanguinity in some of the parents give support to the speculation of previous investigators that the disease may represent an inborn error of metabolism especially of pyruvate metabolism. 11 references, 15 figures, 1 table.

A Special Section on Reading Research--Murder Your Darlings: A Scientific Response to the Voice of Evidence in Reading Research

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Garan, Elaine M.

2005-01-01

Writers know how easy it is to be seduced by their own cleverness. Words and ideas have a way of turning heads as they take on lives of their own. However, the time comes when good writers must harden their hearts, sharpen the axe, and murder their darlings. The same must be said of good scientists. Even more so than with writing, ethical…

Woman in Patriarchal Culture: Gender Discrimination and Intersectionality Portrayed in Bob Darling by Carolyn Cooke

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Ida Rosida; Lestari Rejeki

2017-01-01

This  article  examines  gender  discrimination,  and  investigates  the  relation  between  gender  and social  class  relation  experienced  by  the  main  female  character,  Carla,  in  the  short  story  entitled Bob Darling by Carolyn Cooke. The method used in this study is descriptive qualitative applying the  concept  of  gender  discrimination  by  Mansour  Fakih  and  the  concept  of  intersectionality  by Kimberlé Crenshaw about the connection of multiple dimensions, such as gende...

Orofacial manifestations of histoplasmosis in HIV-positive patients: a case report.

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Gomes Ferreira, O; Vieira Fernandes, A; Sebastião Borges, A; Simão Ferreira, M; Mota Loyola, A

2001-01-01

Amongst the main opportunistic diseases that affect the HIV-positive patient, histoplasmosis is found. This systemic mycosis caused by the fungus Histoplasma capsulatum has the capacity to disseminate from the lung to the skin and oral mucosa. Oral lesions of histoplasmosis can be found with ulcerated or nodular aspect, being always very painful and infiltrating the mucosa. When they are present in the mouth, they strongly indicate the presence of some kind of immunosuppression. This study shows the disease's evolution in an HIV-positive patient, who presented several ulcerated lesions in the oral cavity and facial skin. The symptomatology and clinical aspects of the lesions were not specific for the disease, and due to this, the diagnosis was obtained by cytological smear and oral biopsy. The results of the exams defined the disseminated picture of the infection. The treatment plan involved the use of amphotericin B for the lesions' remission, and, following this, itraconazole was administered in the maintenance phase.

Histoplasmosis suprarrenal incidental

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C. Nine

2002-12-01

Full Text Available El hallazgo de masas adrenales detectadas mediante técnicas ecográficas o tomográficas solicitadas por algún otro motivo, y por ello incidentales, constituye un nuevo desafío diagnóstico. El paciente que presentamos se encontraba asintomático y no refería antecedentes patológicos. Una ecografía mostró agrandamiento de la glándula suprarrenal derecha, que medía 66 por 33mm. La tomografía computada mostró agrandamiento irregular de ambas suprarrenales. Se descartaron neoplasias extra-adrenales y tumores hiperfuncionantes. Se realizó una biopsia guiada por tomografía, y el estudio histopatológico informó Histoplasma capsulatum. El paciente vivía en una zona endémica para esta enfermedad y, por exposición laboral, tenía contacto diario con excremento de aves. La histoplasmosis es una causa infrecuente de masas adrenales bilaterales en el huesped inmu-nocompetente.

Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature

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Nancy A. Rihana

2014-01-01

Full Text Available Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare. Case Presentation. We report a rare case of histoplasmosis that presented as persistent fever and abnormal liver function tests in a 66-year-old female with rheumatoid arthritis, receiving infliximab. Conclusion. Emphasizing histoplasmosis as a major cause of acute granulomatous hepatitis and fever of unknown origin in cell mediated immunodeficient population, this case highlights the need for high index of suspicion and the importance of prompt diagnosis since any delay of treatment can be life threatening in this population.

Histoplasmosis presenting as granulomatous hepatitis: case report and review of the literature.

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Rihana, Nancy A; Kandula, Manasa; Velez, Ana; Dahal, Kumud; O'Neill, Edward B

2014-01-01

Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare. Case Presentation. We report a rare case of histoplasmosis that presented as persistent fever and abnormal liver function tests in a 66-year-old female with rheumatoid arthritis, receiving infliximab. Conclusion. Emphasizing histoplasmosis as a major cause of acute granulomatous hepatitis and fever of unknown origin in cell mediated immunodeficient population, this case highlights the need for high index of suspicion and the importance of prompt diagnosis since any delay of treatment can be life threatening in this population.

Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up

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Avigdor Hevroni

2018-01-01

Full Text Available A teenage girl was evaluated for recurrent right pneumonia. The evaluation revealed a calcified mediastinal mass that compressed the right intermediate and middle lobar bronchi, as well as the right pulmonary artery and veins. The clinical picture together with imaging studies and borderline positive serology testing suggested a diagnosis of fibrosing mediastinitis associated with histoplasmosis. This rare condition is characterized by the local proliferation of invasive fibrous tissue within the mediastinum due to a hyperimmune reaction to Histoplasma capsulatum. Antifungal and anti-inflammatory therapies are usually ineffective, and surgical intervention contains a high morbidity risk. Palliative surgery and stenting of the compressed airway have been suggested. In the past, the prognosis was thought to be poor, but recent studies demonstrate a more positive outcome. Our patient had been radiologically and functionally stable under follow-up for over thirteen years and has married and delivered two healthy children, both following an uneventful pregnancy.

Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis

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Alexandra I. Medeiros

2015-01-01

Full Text Available Histoplasma capsulatum (Hc induces a pulmonary disease in which leukotrienes promote activation and recruitment of effectors cells. It is also well-recognized that leukotriene B4 (LTB4 and platelet-activating factor (PAF induce leukocyte recruitment to inflammatory sites. We investigated the impact of pulmonary Hc infection on PMN migration to a remote inflammatory site. Our results show that pulmonary Hc infection impairs LTB4- or PAF-stimulated PMN recruitment to air pouch. Yet, remote inflammation did not modify PMN numbers in the bronchoalveolar lavage fluid (BALF of Hc-infected mice. Interestingly, the concomitant administration of PAF and LTB4 receptor antagonists inhibited PMN recruitment to both BALF and the remote site, demonstrating cooperation between both mediators. Along that line, our results show that PAF-elicited PMN chemotaxis was abrogated in 5-lipoxygenase-deficient animals. These results suggest caution in the indiscriminate use of anti-inflammatory drugs during infectious diseases.

Muddied Waters: the case for mitigating sediment and nutrient flux to optimise restoration response in the Murray-Darling Basin, Australia.

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Peter Andrew Gell

2016-03-01

Full Text Available The waters of the Murray Darling Basin, Australia, have endured multiple stressors for more than a century. Detectable salinisation impacts are evident from 1880 CE and elevated fluxes of sediments and nutrients are now widespread. Most wetlands examined paleolimnologically have shown increased sedimentation rates or have lost aquatic plant communities due to the shading effect of increased turbidity, prompting the observation that the waterways of the Murray Darling Basin are among ten Australian ecosystems most at risk from tipping points. This post-European heightened sediment flux threatens the potential ecological recovery from the application of scarce and expensive environmental water. Nutrients and fine sediments are implicated as drivers of regime shifts that advantage phytoplankton and inhibit the growth of productive macrophyte beds. However, with the river channels identified as likely sources of sediments and sediment-bound phosphorous, it remains possible that the documented ecological changes represent an ongoing response from continued doses from the River. Syntheses of multiple paleolimnological records provide evidence for the management focus to be on sediment supply to maximise the ecological benefit from environmental flow allocations. Here we use paleolimnology to examine in detail the nature and magnitude of the response in a subset of 17 wetlands, to propose means of optimising the ecological bounce from the release of river waters, encumbered with high doses of sediments and nutrients, to wetlands and floodplains.

Prioritizing Wetlands for Waterbirds in a Boom and Bust System: Waterbird Refugia and Breeding in the Murray-Darling Basin.

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Bino, Gilad; Kingsford, Richard T; Porter, John

2015-01-01

Dryland rivers have considerable flow variability, producing complex ecosystems, processes, and communities of organisms that vary over space and time. They are also among the more vulnerable of the world's ecosystems. A key strategy for conservation of dryland rivers is identifying and maintaining key sites for biodiversity conservation, particularly protecting the quantity and quality of flow and flooding regimes. Extreme variability considerably challenges freshwater conservation planning. We systematically prioritised wetlands for waterbirds (simultaneously for 52 species), across about 13.5% of the Murray-Darling Basin (1,061,469 km2), using a 30-year record of systematic aerial surveys of waterbird populations. Nine key wetlands in this area, primarily lakes, floodplains, and swamps, consistently contributed to a representation target (80%) of total abundances of all 52 waterbird species. The long temporal span of our data included dramatic availability (i.e., booms) and scarcity (i.e., busts) of water, providing a unique opportunity to test prioritisation at extremes of variation. These extremes represented periods when waterbirds were breeding or concentrating on refugia, varying wetland prioritisation. In dry years, important wetlands for waterbirds were riverine and lacustrine (12 wetlands) but this changed in wet years to lacustrine and palustrine (8 wetlands). Such variation in ecosystem condition substantially changes the relative importance of individual wetlands for waterbirds during boom and bust phases. Incorporating this variability is necessary for effective conservation of Murray-Darling Basin waterbirds, with considerable generality for other similarly variable systems around the world.

Prioritizing Wetlands for Waterbirds in a Boom and Bust System: Waterbird Refugia and Breeding in the Murray-Darling Basin.

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Gilad Bino

Full Text Available Dryland rivers have considerable flow variability, producing complex ecosystems, processes, and communities of organisms that vary over space and time. They are also among the more vulnerable of the world's ecosystems. A key strategy for conservation of dryland rivers is identifying and maintaining key sites for biodiversity conservation, particularly protecting the quantity and quality of flow and flooding regimes. Extreme variability considerably challenges freshwater conservation planning. We systematically prioritised wetlands for waterbirds (simultaneously for 52 species, across about 13.5% of the Murray-Darling Basin (1,061,469 km2, using a 30-year record of systematic aerial surveys of waterbird populations. Nine key wetlands in this area, primarily lakes, floodplains, and swamps, consistently contributed to a representation target (80% of total abundances of all 52 waterbird species. The long temporal span of our data included dramatic availability (i.e., booms and scarcity (i.e., busts of water, providing a unique opportunity to test prioritisation at extremes of variation. These extremes represented periods when waterbirds were breeding or concentrating on refugia, varying wetland prioritisation. In dry years, important wetlands for waterbirds were riverine and lacustrine (12 wetlands but this changed in wet years to lacustrine and palustrine (8 wetlands. Such variation in ecosystem condition substantially changes the relative importance of individual wetlands for waterbirds during boom and bust phases. Incorporating this variability is necessary for effective conservation of Murray-Darling Basin waterbirds, with considerable generality for other similarly variable systems around the world.

Predictability of current and future multi-river discharges: Ganges, Brahmaputra, Yangtze, Blue Nile, and Murray-Darling rivers

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Jian, Jun

2007-12-01

Determining river discharge is of critical importance to many societies as they struggle with fresh water supply and risk of flooding. In Bangladesh, floods occur almost every year but with sufficient irregularity to have adverse social and economical consequences. Important goals are to predict the discharge to be used for the optimization of agricultural practices, disaster mitigation and water resource management. The aim of this study is to determine the predictability of river discharge in a number of major rivers on time scale varying from weeks to a century. We investigated predictability considering relationship between SST and discharge. Next, we consider IPCC model projections of river discharge while the models are statistically adjusted against observed discharges. In this study, we consider five rivers, the Ganges, the Brahmaputra, the Yangtze, the Blue Nile, and the Murray-Darling Rivers. On seasonal time scales, statistically significant correlations are found between mean monthly equatorial Pacific sea surface temperature (SST) and the summer Ganges discharge with lead times of 2-3 months due to oscillations of the El Nino-Southern Oscillation (ENSO) phenomena. In addition, there are strong correlations in the southwest and northeast Pacific. These, too, appear to be tied to the ENSO cycle. The Brahmaputra discharge, on the other hand, shows somewhat weaker relationships with tropical SST. Strong lagged correlations relationships are found with SST in the Bay of Bengal but these are the result of very warm SSTs and exceptional Brahmaputra discharge during the summer of 1998. When this year is removed from the time series, relationships weaken everywhere except in the northwestern Pacific for the June discharge and in areas of the central Pacific straddling the equator for the July discharge. The relationships are relative strong, but they are persistent from month to month and suggest that two different and sequential factors influence Brahmaputra

[Imported histoplasmosis in Navarra: presentation of four cases].

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Navascués, Ana; Rodríguez, Irene; Repáraz, Jesús; Salvo, Soledad; Gil-Setas, Alberto; Martínez Peñuela, José María

2011-01-01

Histoplasmosis is a fungal infection caused by the dimorphic fungi Histoplasma capsulatum. Its incidence in Spain has increased in recent years, mainly due to the increased presence of immigrants from Latin America and increased travel to the continent for tourism and cooperation. Our aim was to review the clinical characteristics of cases of histoplasmosis diagnosed in our hospital during the last six years. We diagnosed 4 cases from 4 patients from South America, 3 of whom were HIV positive and 1 diagnosed with dermatomyositis was treated with immunosuppressive drugs. The laboratory diagnosis was carried out by histological and microbiological study, by culture and specific PCR directly on the sample. As it is an imported infection there needs to be a high level of suspicion and a detailed history taken to get a diagnosis. This infection requires a differential diagnosis between febrile syndrome in immunosuppressed patients, both HIV positive and immunosuppressive therapy, which originate from endemic areas, or who have a history of staying in them. Copyright © 2010 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Extracellular Vesicle-Associated Transitory Cell Wall Components and Their Impact on the Interaction of Fungi with Host Cells.

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Nimrichter, Leonardo; de Souza, Marcio M; Del Poeta, Maurizio; Nosanchuk, Joshua D; Joffe, Luna; Tavares, Patricia de M; Rodrigues, Marcio L

2016-01-01

Classic cell wall components of fungi comprise the polysaccharides glucans and chitin, in association with glycoproteins and pigments. During the last decade, however, system biology approaches clearly demonstrated that the composition of fungal cell walls include atypical molecules historically associated with intracellular or membrane locations. Elucidation of mechanisms by which many fungal molecules are exported to the extracellular space suggested that these atypical components are transitorily located to the cell wall. The presence of extracellular vesicles (EVs) at the fungal cell wall and in culture supernatants of distinct pathogenic species suggested a highly functional mechanism of molecular export in these organisms. Thus, the passage of EVs through fungal cell walls suggests remarkable molecular diversity and, consequently, a potentially variable influence on the host antifungal response. On the basis of information derived from the proteomic characterization of fungal EVs from the yeasts Cryptoccocus neoformans and Candida albicans and the dimorphic fungi Histoplasma capsulatum and Paracoccidioides brasiliensis, our manuscript is focused on the clear view that the fungal cell wall is much more complex than previously thought.

Histoplasmosis del sistema nervioso central en un paciente inmunocompetente

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Natalia Osorio

2014-12-01

Full Text Available La histoplasmosis es una afección polifacética producida por el hongo dimorfo Histoplasma capsulatum, cuyas esporas son inhaladas y llegan al pulmón, órgano primario de infección. La forma meníngea, considerada como una de las manifestaciones más graves de esta micosis, suele presentarse en individuos con alteraciones en la inmunidad celular: pacientes con síndrome de inmunodeficiencia humana adquirida, con lupus eritematoso sistémico o con trasplante de órgano sólido, así como en lactantes, debido a su inmadurez inmunológica. La forma de presentación más usual es de resolución espontánea y se observa en individuos inmunocompetentes que se han expuesto a altas concentraciones de conidias y fragmentos miceliares del hongo. En estas personas, la afección se manifiesta por trastornos pulmonares y por la posterior diseminación a otros órganos y sistemas. Se presenta un caso de histoplasmosis del sistema nervioso central en un niño inmunocompetente.

Systemic fungal infections in patients with human inmunodeficiency virus.

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Rodríguez-Cerdeira, C; Arenas, R; Moreno-Coutiño, G; Vásquez, E; Fernández, R; Chang, P

2014-01-01

Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulatum. In immunocompromised patients, primary pulmonary infection can spread to the skin and meninges. Clinical manifestations appear in patients with a CD4(+) lymphocyte count of less than 150 cells/μL. Coccidioidomycosis is a systemic mycosis caused by Coccidioides immitis and Coccidioides posadasii. It can present as diffuse pulmonary disease or as a disseminated form primarily affecting the central nervous system, the bones, and the skin. Cryptococcosis is caused by Cryptococcus neoformans (var. neoformans and var. grubii) and Cryptococcus gattii, which are members of the Cryptococcus species complex and have 5 serotypes: A, B, C, D, and AD. It is a common opportunistic infection in patients with human immunodeficiency virus (HIV)/AIDS, even those receiving antiretroviral therapy. Histopathologic examination and culture of samples from any suspicious lesions are essential for the correct diagnosis of systemic fungal infections in patients with HIV/AIDS. Copyright © 2011 Elsevier España, S.L. and AEDV. All rights reserved.

Institutional path dependence and environmental water recovery in Australia’s Murray-Darling Basin

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Graham R. Marshall

2016-10-01

Full Text Available The concept of institutional path dependence offers useful ways of understanding the trajectories of water policy reforms and how past institutional arrangements, policy paradigms and development patterns constrain current and future choices and limit institutional adaptability. The value of this concept is demonstrated through an analysis of environmental water recovery in Australia’s Murray-Darling Basin, where while significant water volumes have been reallocated to the environment, the costs have also been significant. While there are significant lessons from the Australian experience, attempts to emulate the approach involve substantive risks and may be prohibitively costly for less wealthy nations. Context-specific institutional analysis is emphasised as fundamental to water reform and critical for reform architecture and sequencing. A key finding is that while crisis can provide powerful catalysts for institutional innovation, institutional path dependence in the absence of active and disruptive policy entrepreneurs fosters a strong tendency to reinforce the status quo and limit innovation, potentially exposing social-ecological systems to greater shocks due to climate change and other sources of escalating uncertainty.

Steps toward “useful” hydroclimatic scenarios for water resource management in the Murray-Darling Basin

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Kiem, Anthony S.; Verdon-Kidd, Danielle C.

2011-12-01

There is currently a distinct gap between what climate science can provide and information that is practically useful for (and needed by) natural resource managers. Improved understanding, and model representations, of interactions between the various climate drivers (both regional and global scale), combined with increased knowledge about the interactions between climate processes and hydrological processes at the regional scale, is necessary for improved attribution of climate change impacts, forecasting at a range of temporal scales and extreme event risk profiling (e.g., flood, drought, and bushfire). It is clear that the science has a long way to go in closing these research gaps; however, in the meantime water resource managers in the Murray-Darling Basin, and elsewhere, require hydroclimatic projections (i.e., seasonal to multidecadal future scenarios) that are regionally specific and, importantly, take into account the impacts, and associated uncertainties, of both natural climate variability and anthropogenic change. The strengths and weaknesses of various approaches for supplying this information are discussed in this paper.

Evolving Governance and Contested Water Reforms in Australia’s Murray Darling Basin

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Jason Alexandra

2018-01-01

Full Text Available This paper explores the ways water governance adapts to changing social values and political imperatives by examining the case of water policy reforms in Australia’s Murray Darling Basin. Over more than two decades, Australia’s water reforms have explicitly aimed to promote ecological sustainability and economic efficiency, attempting to balance pro-market, micro-economic reforms with broader social and sustainability goals. Despite the formality of Australia’s intergovernmental agreements, water reforms have been expensive and heavily contested, experiencing many implementation challenges. However, water market reforms have generally been regarded as successful, enabling the reallocation of water for environmental and extractive uses, contributing to flexibility and adaptive capacity. Recognising that discursive contestation is central to policy development, the paper documents the way the reform processes have attempted to broker compromises between three competing policy paradigms—national development, economic rationalism and environmentalism. These inherent tensions resulted in prolonged contests for influence over policy directions long after formal statements of policy intent by Governments. Given that climate change is driving the need for water governance reforms, the paper looks to what lessons can be learnt about the redesigns of meta-governance arrangements, including through structured commitments to independent audits and evaluations that can provide the feedback needed for adaptive governance and policy learning.

Cognitive impairment and memory loss associated with histoplasmosis: a case study.

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Loughan, Ashlee R; Perna, Robert; Hertza, Jeremy

2014-01-01

Histoplasmosis is a rare disease caused by inhalation of the fungus Histoplasma capsulatum. It can spread via cerebral circulation to the central nervous system as a manifestation of a disseminated infection; particularly in patients with immune suppression, which can result in isolated ring-enhancing lesions and inflammation in the brain. Of the reported disseminated histoplasmosis cases (approximately 1 in 2000 per year), only 5-20% have evidence of central nervous system involvement. This paper reviews a single case study of a 57-year-old female diagnosed with disseminated CNS histoplasmosis. Patient's complaints included reduced short-term memory, word-finding problems, and difficulty organizing, making decisions, getting lost while driving, recalling names, retaining information while reading, and slowed processing speed. There was also a history of mild depression and anxiety. Direct testing revealed deficits in multiple cognitive domains including complex attention, processing speed, semantic fluency, visual scanning, motor speed, set-shifting, naming, nonverbal memory, and verbal memory. Neuropsychological deficits suggest cortical and subcortical brain dysfunction, including anterior, temporal, and mesial-temporal regions. This case illustrates the need for neuropsychologists to understand histoplasmosis, the related pathophysiology, and the neuropsychological impact; particularly with the potential for delayed progression.

[A comparative study of blood culture conventional method vs. a modified lysis/centrifugation technique for the diagnosis of fungemias].

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Santiago, Axel Rodolfo; Hernández, Betsy; Rodríguez, Marina; Romero, Hilda

2004-12-01

The purpose of this work was to compare the efficacy of blood culture conventional method vs. a modified lysis/centrifugation technique. Out of 450 blood specimens received in one year, 100 where chosen for this comparative study: 60 from patients with AIDS, 15 from leukemic patients, ten from febrile neutropenic patients, five from patients with respiratory infections, five from diabetics and five from septicemic patients. The specimens were processed, simultaneously, according to the above mentioned methodologies with daily inspections searching for fungal growth in order to obtain the final identification of the causative agent. The number (40) of isolates recovered was the same using both methods, which included; 18 Candida albicans (45%), ten Candida spp. (25%), ten Histoplasma capsulatum (25%), and two Cryptococcus neoformans (5%). When the fungal growth time was compared by both methods, growth was more rapid when using the modified lysis/centrifugation technique than when using the conventional method. Statistical analysis revealed a significant difference (pcentrifugation technique showed to be more efficacious than the conventional one, and therefore the implementation of this methodology is highly recommended for the isolation of fungi from blood.

Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy).

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Guimarães, Lucinda Calheiros; Silva, Ana Cristina Araújo Lemos da; Micheletti, Adilha Misson Rua; Moura, Everton Nunes Melo; Silva-Vergara, Mario Léon; Tostes, Sebastião; Adad, Sheila Jorge

2017-04-03

Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy.

Histoplasmosis en pacientes con sida: Un estudio de cohorte en Medellín, Colombia Histoplasmosis in AIDS patients: A cohort study in Medellín, Colombia

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Gloria Velásquez Uribe

2010-12-01

Full Text Available Introducción: la histoplasmosis es una micosis endémica en nuestro país y una complicación relativamente frecuente de los pacientes con sida. El objetivo del estudio era identificar las características clínicas, epidemiológicas y los factores de riesgo asociados a la mortalidad en pacientes con sida coinfectados con histoplasmosis. Materiales y métodos: se realizó un estudio de cohorte retrospectivo en el Hospital Universitario San Vicente de Paúl, en Medellín, con 1177 pacientes con VIH atendidos en un programa especializado de sida. Se identificaron los pacientes con histoplasmosis confirmada por aislamiento del hongo, o identificaci&oacut compatibles con Histoplasma capsulatum, mediante microscopía. Se analizaron variables demográficas, clínicas, de laboratorio, comorbilidad, tratamiento recibido y mortalidad. Resultados: La histoplasmosis afectó a 44 de 709 pacientes con sida (6,2%. Entre éstos, el 95,4% tuvo fiebre, el 54,5% enfermedad diseminada e;n de levaduras intracelulares y el 61,3% compromiso pulmonar. El cultivo fue positivo en el 89,3% y la histopatología en el 93,3%. Se encontró tuberculosis concomitante en el 15,9% y neumocistosis en el 11,4%. La mortalidad fue del 22,7%. El riesgo de morir fue mayor en pacientes con formas diseminadas (todas las muertes ocurrieron en sujetos con este tipo de compromiso, disnea (RR 13; IC95% 1,8-93,8, hipotensión (RR 4,5; IC95% 1,6-13,1, deshidrogenasa láctica (DHL >2 veces (RR 5,2; IC95% 1,2-22,5, y fue menor en quienes recibieron Anfotericina B (RR 0,3; IC95% 0,1-0,8. Discusión: en la región, la histoplasmosis es frecuente en pacientes con sida, y el rendimiento diagnóstico de las técnicas de rutina para H. capsulatum es alto, por lo que deben solicitarse en cualquier caso compatible. Demostrar la comorbilidad sida-histoplasmosis no descarta otras infecciones oportunistas. Los pacientes con formas diseminadas, disnea, hipotensión y DHL alta tienen mayor riesgo de muerte

A Trans-disciplinary Hydrogeological Systems Analysis Approach for Identifying and Assessing Managed Aquifer Recharge Options: Example from the Darling River Floodplain, N.S.W., Australia

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Lawrie, K.; Brodie, R. S.; Tan, K. P.; Halas, L.; Magee, J.; Gow, L.; Christensen, N. B.

2013-12-01

Surface water availability and quality generally limits managed aquifer recharge (MAR) opportunities in inland Australia's highly salinized landscapes and groundwater systems. Economic factors also commonly limit MAR investigations to shallow freshwater groundwater systems near existing infrastructure. Aquifer opportunities lie mainly in zones of fresh groundwater in relatively thin fluvial sedimentary aquifer systems with highly variable hydraulic properties. As part of a broader strategy to identify water savings in the Murray-Darling Basin, the Broken Hill Managed Aquifer Recharge (BHMAR) project was tasked with identifying and assessing MAR and/or groundwater extraction options to reduce evaporative losses from existing surface water storages, secure Broken Hill's water supply, protect the local environment and heritage, and return water to the river system. A trans-disciplinary research approach was used to identify and assess MAR options across a broad area of the Darling River floodplain. This methodology enabled the team to recognise fundamental problems in discipline approaches, helped identify critical data gaps, led to significant innovation across discipline boundaries, was critical in the development of a new hydrogeological conceptual model, facilitated development of new models of landscape, geological and tectonic evolution of the study area, and enabled completion of pre-commissioning maximal and residual MAR risk assessments. An airborne electromagnetics (AEM) survey, acquired over a large (>7,500 sq km) area of the Darling Floodplain, enabled rapid identification of a multi-layer sequence of aquifers and aquitards, while a phased assessment methodology was developed to rapidly identify and assess over 30 potential MAR targets (largely in fresh groundwater zones within palaeochannels and at palaeochannel confluences). Hydraulic properties were confirmed by a 7.5 km drilling program (100 sonic and rotary mud holes), and complementary field

[Immunohistochemistry diagnosis of fungal infections].

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Rocha, D C; Duarte, M I; Pagliari, C; de Oliveira, M S

1998-01-01

Because the mycosis incidence has increased a lot with the appearing of AIDS, the Immunohistochemistry study among fungus shows the importance of fast methods for their identification that have advantage of been a durable method in comparison with immunofluorescence and the possibility of making retrospective studies in material embedded in paraffin. The Immunohistochemistry reaction with Histoplasma capsulatum, Pneumocystis carinii; and Criptococcus neoformans antibodies were sensitive, specifics, and intensely positive in all the cases previously diagnosed as Histoplasmosis, Pneumocystosis and Cryptococcosis, without cross-reaction with other fungus; while the anti-Candida albicans antibody showed weak positiveness in four Histoplasmosis cases, in one of Paracoccidioidomycosis cases and Sporotrichosis case; and the reactions with the antibody anti-P. brasiliensis were intensely positive in all the Paracoccidioidomycosis cases and weakly positive in two Histoplasmosis and two of the four Candidiasis cases. The previous identification of each fungi on tissue sample was made by Grocott method. This preliminary study showed that it is necessary to use other kinds of antibody and fungus, in order to get more details about the possible occurrence of cross-reactions. We suggest the use of new antibodies, with new standardizations in order to find the best titles for each reaction and eliminate the cross-reactions.

High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala.

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Samayoa, Blanca; Roy, Monika; Cleveland, Angela Ahlquist; Medina, Narda; Lau-Bonilla, Dalia; Scheel, Christina M; Gomez, Beatriz L; Chiller, Tom; Arathoon, Eduardo

2017-07-01

Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients ≥ 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for Histoplasma capsulatum . Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases.

Risk management frameworks: supporting the next generation of Murray-Darling Basin water sharing plans

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G. M. Podger

2014-09-01

Full Text Available Water jurisdictions in Australia are required to prepare and implement water resource plans. In developing these plans the common goal is realising the best possible use of the water resources – maximising outcomes while minimising negative impacts. This requires managing the risks associated with assessing and balancing cultural, industrial, agricultural, social and environmental demands for water within a competitive and resource-limited environment. Recognising this, conformance to international risk management principles (ISO 31000:2009 have been embedded within the Murray-Darling Basin Plan. Yet, to date, there has been little strategic investment by water jurisdictions in bridging the gap between principle and practice. The ISO 31000 principles and the risk management framework that embodies them align well with an adaptive management paradigm within which to conduct water resource planning. They also provide an integrative framework for the development of workflows that link risk analysis with risk evaluation and mitigation (adaptation scenarios, providing a transparent, repeatable and robust platform. This study, through a demonstration use case and a series of workflows, demonstrates to policy makers how these principles can be used to support the development of the next generation of water sharing plans in 2019. The workflows consider the uncertainty associated with climate and flow inputs, and model parameters on irrigation and hydropower production, meeting environmental flow objectives and recreational use of the water resource. The results provide insights to the risks associated with meeting a range of different objectives.

Brote de histoplasmosis en la Escuela de Cadetes de la Base Aérea de Morón, Provincia de Buenos Aires, República Argentina Histoplasmosis outbreak in Morón, Buenos Aires Province, Argentina

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R. Negroni

2010-12-01

Full Text Available Se describe un brote de histoplasmosis que afectó a 6 cadetes de la Fuerza Aérea Argentina, sin antecedentes patológicos previos. Todos consultaron por problemas respiratorios después de haber limpiado un hangar. En ese recinto se encontraron abundantes deyecciones de animales, presuntamente de palomas y murciélagos. Los pacientes sufrieron fiebre, mialgias, taquipnea y tos no productiva. Las radiografías y tomografías de tórax mostraron imágenes pulmonares micronodulares, engrosamiento de los tabiques interalveolares y adenopatías hiliares. Todos tuvieron una evolución favorable y no requirieron tratamiento antifúngico. Las pruebas de inmunodifusión y contrainmunoelectroforesis con antígenos de Histoplasma capsulatum fueron positivas, al igual que las intradermorreacciones con histoplasmina. Se recogieron 5 muestras de tierra del lugar, las que fueron inoculadas por vía intraperitoneal a 20 hámsteres. De los cultivos de hígado y bazo de dichos animales se consiguió aislar la fase micelial de H. capsulatum. La cepa aislada se comparó con las obtenidas de 12 pacientes argentinos utilizando perfiles genéticos y se observó un clado único con más de 96% de similitud, lo que confirma la homogeneidad de las cepas argentinas. Si bien la histoplasmosis es endémica en la Pampa húmeda, este es el primer brote totalmente documentado al sur del paralelo 34°.An histoplasmosis outbreak affecting 6 previously healthy Air Force cadets is herein presented. The patients suffered from fever and respiratory symptoms after having cleaned an abandoned hangar soiled with pigeons and bat droppings. They all presented fever, myalgia, tachypnea, and nonproductive cough. Chest X-ray and CT scan studies showed disseminated reticulonodular images affecting both lungs. Hiliar adenomegalies were also observed. All patients achieved a favourable outcome without antifungal treatment. Both serologic tests searching for specificic antibodies

A conceptual model for groundwater - surface water interactions in the Darling River Floodplain, N.S.W., Australia

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Brodie, R. S.; Lawrie, K.; Somerville, P.; Hostetler, S.; Magee, J.; Tan, K. P.; Clarke, J.

2013-12-01

Multiple lines of evidence were used to develop a conceptual model for interaction between the Darling River and associated floodplain aquifers in western New South Wales, Australia. Hydrostratigraphy and groundwater salinities were mapped using airborne electromagnetics (AEM), validated by sonic-core drilling. The AEM was highly effective in mapping groundwater freshening due to river leakage in discrete zones along the river corridor. These fresh resources occurred in both the unconfined Quaternary aquifers and the underlying, largely semi-confined Pliocene aquifers. The AEM was also fundamental to mapping the Blanchetown Clay aquitard which separates these two aquifer systems. Major-ion chemistry highlighted a mixing signature between river waters and groundwaters in both the Quaternary and Pliocene aquifers. Stable isotope data indicates that recharge to the key Pliocene aquifers is episodic and linked to high-flow flood events rather than river leakage being continuous. This was also evident when groundwater chemistry was compared with river chemistry under different flow conditions. Mapping of borehole levels showed groundwater mounding near the river, emphasising the regional significance of losing river conditions for both aquifer systems. Critically, rapid and significant groundwater level responses were measured during large flood events. In the Pliocene aquifers, continuation of rising trends after the flood peak receded confirms that this is an actual recharge response rather than hydraulic loading. The flow dependency of river leakage can be explained by the presence of mud veneers and mineral precipitates along the Darling River channel bank when river flows are low. During low flow conditions these act as impediments to river leakage. During floods, high flow velocities scour these deposits, revealing lateral-accretion surfaces in the shallow scroll plain sediments. This scouring allows lateral bank recharge to the shallow aquifer. During flood

The evolution and performance of river basin management in the Murray-Darling Basin

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Andrew Ross

2016-09-01

Full Text Available We explore bioregional management in the Murray-Darling Basin (MDB in Australia through the institutional design characteristics of the MDB River Basin Organization (RBO, the actors and organizations who supported and resisted the establishment of the RBO, and the effectiveness of the RBO. During the last 25 years, there has been a major structural reform in the MDB RBO, which has changed from an interstate coordinating body to an Australian government agency. Responsibility for basin management has been centralized under the leadership of the Australian government, and a comprehensive integrated Basin plan has been adopted. The driving forces for this centralization include national policy to restore river basins to sustainable levels of extraction, state government difficulties in reversing overallocation of water entitlements, the millennium drought and its effects, political expediency on the part of the Australian government and state governments, and a major injection of Australian government funding. The increasing hierarchy and centralization of the MDB RBO does not follow a general trend toward multilevel participative governance of RBOs, but decentralization should not be overstated because of the special circumstances at the time of the centralization and the continuing existence of some decentralized elements, such as catchment water plans, land use planning, and water quality. Further swings in the centralization-decentralization pendulum could occur. The MDB reform has succeeded in rebalancing Basin water allocations, including an allocation for the environment and reduced diversion limits. There are some longer term risks to the implementation of reform, including lack of cooperation by state governments, vertical coordination difficulties, and perceived reductions in the accountability and legitimacy of reform at the local level. If implementation of the Basin plan is diverted or delayed, a new institution, the Commonwealth

Mycobacterial and nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus infection: A prospective, cohort study

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Afessa Bekele

2001-09-01

Full Text Available Abstract Background A prospective observational study was done to describe nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus (HIV infection. Methods The study included 1,225 consecutive hospital admissions of 599 HIV-infected patients treated from April 1995 through March 1998. Data included demographics, risk factors for HIV infection, Acute Physiology and Chronic Health Evaluation (APACHE II score, pulmonary complications, CD4+ lymphocyte count, hospital stay and case-fatality rate. Results Patient age (mean ± SD was 38.2 ± 8.9 years, 62% were men, and 84% were African American. The median APACHE II score was 14, and median CD4+ lymphocyte count was 60/μL. Pulmonary complications were Pneumocystis carinii pneumonia (85 in 78 patients, Mycobacterium avium complex (51 in 38, Mycobacterium tuberculosis (40 in 35, Mycobacterium gordonae (11 in 11, Mycobacterium kansasii (10 in 9, Cytomegalovirus (10 in 10, Nocardia asteroides (3 in 3, fungus ball (2 in 2, respiratory syncytial virus (1, herpes simplex virus (1, Histoplasma capsulatum (1, lymphoma (3 in 3, bronchogenic carcinoma (2 in 2, and Kaposi sarcoma (1. The case-fatality rate of patients was 11% with Pneumocystis carinii pneumonia; 5%, Mycobacterium tuberculosis; 6%, Mycobacterium avium complex; and 7%, noninfectious pulmonary complications. Conclusion Most pulmonary complications in hospitalized patients with HIV are from Pneumocystis and mycobacterial infection.

Glutathione-dependent extracellular ferric reductase activities in dimorphic zoopathogenic fungi

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Zarnowski, Robert; Woods, Jon P.

2009-01-01

In this study, extracellular glutathione-dependent ferric reductase (GSH-FeR) activities in different dimorphic zoopathogenic fungal species were characterized. Supernatants from Blastomyces dermatitidis, Histoplasma capsulatum, Paracoccidioides brasiliensis and Sporothrix schenckii strains grown in their yeast form were able to reduce iron enzymically with glutathione as a cofactor. Some variations in the level of reduction were noted amongst the strains. This activity was stable in acidic, neutral and slightly alkaline environments and was inhibited when trivalent aluminium and gallium ions were present. Using zymography, single bands of GSH-FeRs with apparent molecular masses varying from 430 to 460 kDa were identified in all strains. The same molecular mass range was determined by size exclusion chromatography. These data demonstrate that dimorphic zoopathogenic fungi produce and secrete a family of similar GSH-FeRs that may be involved in the acquisition and utilization of iron. Siderophore production by these and other fungi has sometimes been considered to provide a full explanation of iron acquisition in these organisms. Our work reveals an additional common mechanism that may be biologically and pathogenically important. Furthermore, while some characteristics of these enzymes such as extracellular location, cofactor utilization and large size are not individually unique, when considered together and shared across a range of fungi, they represent an important novel physiological feature. PMID:16000713

Development of vaccines and their use in the prevention of fungal infections.

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Dixon, D M; Casadevall, A; Klein, B; Mendoza, L; Travassos, L; Deepe, G S

1998-01-01

Vaccine approaches to infectious diseases are widely applied and appreciated. Disciplines such as bacteriology and virology have a rich history of successful vaccine development. The complexity of eukaryotic systems presents additional challenges to the development of vaccines against them. These challenges are being met in the fields of parasitology, and are being revisited for application in oncology. Vaccine opportunities exist in medical mycology. The National Institute of Allergy and Infectious Diseases has held a series of workshops in medical mycology where the need to develop vaccines for fungal diseases was noted and where important opportunities were discussed. Major advances in vaccinology and the technology of antigen preparation and delivery have increased feasibility and heightened interest. The recent epidemic of coccidioidomycosis in the American Southwest has demonstrated the need for developing a vaccine as an effective preventive measure for those living in and for those who subsequently move into regions with the endemic mycoses. The XIIth Congress of the International Society for Human and Animal Mycology included a symposium that summarized new vaccination strategies for selected fungi: Candida albicans, Coccidioides immitis, and Trichophyton verrucosum. The goal of the present summary is to provide representative examples of continuing efforts relating to vaccine development within the medical mycological community highlighting Blastomyces dermatidis, Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis, and Pythiumn insidiosum.

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway.

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Juin-Hua Huang

2015-07-01

Full Text Available Collaboration between heterogeneous pattern recognition receptors (PRRs leading to synergistic coordination of immune response is important for the host to fight against invading pathogens. Although complement receptor 3 (CR3 and Dectin-1 are major PRRs to detect fungi, crosstalk between these two receptors in antifungal immunity is largely undefined. Here we took advantage of Histoplasma capsulatum which is known to interact with both CR3 and Dectin-1 and specific particulate ligands to study the collaboration of CR3 and Dectin-1 in macrophage cytokine response. By employing Micro-Western Array (MWA, genetic approach, and pharmacological inhibitors, we demonstrated that CR3 and Dectin-1 act collaboratively to trigger macrophage TNF and IL-6 response through signaling integration at Syk kinase, allowing subsequent enhanced activation of Syk-JNK-AP-1 pathway. Upon engagement, CR3 and Dectin-1 colocalize and form clusters on lipid raft microdomains which serve as a platform facilitating their cooperation in signaling activation and cytokine production. Furthermore, in vivo studies showed that CR3 and Dectin-1 cooperatively participate in host defense against disseminated histoplasmosis and instruct adaptive immune response. Taken together, our findings define the mechanism of receptor crosstalk between CR3 and Dectin-1 and demonstrate the importance of their collaboration in host defense against fungal infection.

Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy

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Lucinda Calheiros Guimarães

Full Text Available ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases; B - one or two antiretroviral drugs or HAART for less than six months (83 cases; C - HAART for six months or longer (54 cases. In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%, followed by cytomegalovirus (19.2%, Histoplasma capsulatum (6.5%, mycobacteria (5.6%, and Toxoplasma gondii (4.3%. T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV was more frequent in group A compared with groups B and C (p < 0.05; 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy.

Frecuencia de micosis en pacientes inmunosuprimidos de un hospital regional de la Ciudad de México

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Hernández-Hernández Francisca

2003-01-01

Full Text Available OBJETIVO: Aislar e identificar hongos en diferentes especímenes de pacientes inmunocomprometidos, atendidos en un hospital de la Ciudad de México, y determinar su asociación con micosis. MATERIAL Y MÉTODOS: Se realizó un estudio de tipo observacional transversal en pacientes del Hospital Regional General Ignacio Zaragoza, de junio de 1999 a mayo de 2000. De 108 pacientes se procesaron 268 especímenes para estudio micológico que incluyó examen directo, frotis, cultivos y microcultivos en medios específicos además de pruebas bioquímicas. La mayoría de pacientes tenía diagnóstico clínico de tuberculosis pulmonar y de síndrome de inmunodeficiencia adquirida. RESULTADOS: Se obtuvieron 183 aislamientos de levaduras y 66 de hongos filamentosos. Se diagnosticaron 45 micosis que en su mayoría correspondieron a candidosis pulmonar (32 casos. Las especies de Candida más frecuentes asociadas a patología fueron Candida albicans y C parapsilosis. Se obtuvieron cinco aislamientos de Cryptococcus neoformans variedad neoformans, uno de C albidus, tres de Histoplasma capsulatum y uno de Geotrichum candidum, asociados a infección micótica. CONCLUSIONES: El 41.6% de los pacientes estudiados presentaron una micosis asociada principalmente a síndrome de inmunodeficiencia adquirida y a tuberculosis pulmonar.

Histoplasmosis in immunocompetent individuals living in an endemic area in the Brazilian Southeast

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Rivian Christina Lopes Faiolla

2013-07-01

Full Text Available Introduction The distribution of infection by Histoplasma capsulatum in Brazil is heterogeneous, and the number of cases affecting immunocompetent individuals is relatively small. This study reports the epidemiological and clinical data regarding histoplasmosis in non-immunosuppressed individuals. Methods The study included only the immunocompetent patients with histoplasmosis who were diagnosed between 1970 and 2012 at a university hospital located in Ribeirão Preto, State of São Paulo, Brazil. Clinical and epidemiological data were collected retrospectively from the patient records. Results Of the 123 patients analyzed, 95 had an active disease that manifested in the different clinical forms of histoplasmosis. Men were the predominant gender, and most patients resided in the Northeast of the State of São Paulo and in the nearby municipalities of the State of Minas Gerais. The risk factors for acquiring histoplasmosis and prolonged contact in a rural environment were recorded in 43.9% and 82.9% of cases, respectively. Smoking, alcoholism, and comorbidity rates were high among the patients with the chronic pulmonary and subacute/chronic disseminated forms of histoplasmosis. Many patients achieved clinical cure spontaneously, but 58.9% required antifungals; the disease lethality rate was 5.3%. Conclusions Immunocompetent individuals manifested the diverse clinical forms of histoplasmosis over a period of 4 decades, revealing an additional endemic area of this fungal disease in the Brazilian Southeast.

REMOTE-SENSING-BASED BIOPHYSICAL MODELS FOR ESTIMATING LAI OF IRRIGATED CROPS IN MURRY DARLING BASIN

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I. Wittamperuma

2012-07-01

Full Text Available Remote sensing is a rapid and reliable method for estimating crop growth data from individual plant to crops in irrigated agriculture ecosystem. The LAI is one of the important biophysical parameter for determining vegetation health, biomass, photosynthesis and evapotranspiration (ET for the modelling of crop yield and water productivity. Ground measurement of this parameter is tedious and time-consuming due to heterogeneity across the landscape over time and space. This study deals with the development of remote-sensing based empirical relationships for the estimation of ground-based LAI (LAIG using NDVI, modelled with and without atmospheric correction models for three irrigated crops (corn, wheat and rice grown in irrigated farms within Coleambally Irrigation Area (CIA which is located in southern Murray Darling basin, NSW in Australia. Extensive ground truthing campaigns were carried out to measure crop growth and to collect field samples of LAI using LAI- 2000 Plant Canopy Analyser and reflectance using CROPSCAN Multi Spectral Radiometer at several farms within the CIA. A Set of 12 cloud free Landsat 5 TM satellite images for the period of 2010-11 were downloaded and regression analysis was carried out to analyse the co-relationships between satellite and ground measured reflectance and to check the reliability of data sets for the crops. Among all the developed regression relationships between LAI and NDVI, the atmospheric correction process has significantly improved the relationship between LAI and NDVI for Landsat 5 TM images. The regression analysis also shows strong correlations for corn and wheat but weak correlations for rice which is currently being investigated.

The role of stakeholders in Murray-Darling Basin water management: How do irrigators make water use decisions and how can this influence water policy?

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Douglas, E. M.; Wheeler, S. A.; Smith, D. J.; Gray, S.; Overton, I. C.; Crossman, N. D.; Doody, T.

2014-12-01

Water stress and overallocation are at the forefront of water management and policy challenges in Australia, especially in the Murray Darling Basin (MDB). Farmland within the MDB generates 40 percent of Australia's total agricultural production and utilizes 60 percent of all irrigation water withdrawn nationally. The Murray Darling Basin Plan, drafted in 2008 and enacted in November 2012, has at its core the establishment of environmentally sustainable diversion limits based on a threshold of water extraction which, if exceeded, would cause harm to key environmental assets in the MDB. The overall goal of the Plan is to balance economic, social and environmental outcomes within the Basin. Because irrigated agriculture is the major water user in the MDB, it is important to understand the factors that influence irrigation water use. We applied a mental modeling approach to assessing farmer water use decisions. The approach allowed us to solicit and document farmer insights into the multifaceted nature of irrigation water use decisions in the MDB. Following are a few insights gained from the workshops: 1) For both environmental and economic reasons, irrigators in the MDB have become experts in water use and water efficiency. Water managers and government officials could benefit by partnering with farmers and incorporating this expertise into water management decisions. 2) Irrigators in the MDB may have been misperceived when it comes to accepting policy change. Many, if not most, of the farmers we talked to understood the need for, or at least the inevitability of, governmental policies and regulations. But a lack of accountability and predictability has added to the uncertainty in farming decisions. 3) Irrigators in the MDB subscribe to the concept of environmental sustainability, although they might not always agree with how the concept is implemented. Farmers should be recognized for their significant investments in the long-term sustainability of their farms and

[Efficacy of the treatment and secondary antifungal prophylaxis in AIDS-related histoplasmosis. Experience at the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires].

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Negroni, Ricardo; Messina, Fernando; Arechavala, Alicia; Santiso, Gabriela; Bianchi, Mario

Classic histoplasmosis is a systemic endemic mycosis due to Histoplasma capsulatum var. capsulatum. A significant reduction in the morbidity and mortality of AIDS-related histoplasmosis has been observed since the introduction of highly active antiretroviral therapy (HAART) and secondary antifungal prophylaxis. The aim of this study was to determine the current state of prognosis and treatment response of HIV-positive patients with histoplasmosis in the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires City. A retrospective study was conducted using the demographic, clinical, immunological and treatment data of 80 patients suffering from AIDS-related histoplasmosis. Of the 80 cases studied 65 were male, the median age was 36 years, with 73.7% of the patients being drug addicts, 82.5% of the patients was not receiving HAART at diagnosis, and 58.7% of the cases had less than 50 CD4+ cells/μl at the beginning of the treatment. The initial phase of treatment consisted of intravenous amphotericin B and/or oral itraconazole for 3 months, with 78.7% of the cases showing a good clinical response. Only 26/63 patients who were discharged from hospital continued with the follow-up of the HAART, secondary prophylaxis with itraconazole or amphotericin B. Secondary prophylaxis was stopped after more than one year of HAART if the patients were asymptomatic, had two CD 4 + cell counts greater than 150cells/μl, and undetectable viral loads. No relapses were observed during a two-year follow up after prophylaxis was stopped. The treatment of histoplasmosis in HIV-positive patients was effective in 78.8% of the cases. The combination of HAART and secondary antifungal prophylaxis is safe, well tolerated, and effective. The low adherence of patients to HAART and the lack of laboratory kits for rapid histoplasmosis diagnosis should be addressed in the future. The usefulness of primary antifungal prophylaxis for cryptococcosis and histoplasmosis HIV-positive patients

Neuroinfection survey at a neurological ward in a Brazilian tertiary teaching hospital

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Paulo E Marchiori

2011-01-01

Full Text Available OBJECTIVES: This study was undertaken to characterize the neuroinfection profile in a tertiary neurological ward. INTRODUCTION: Neuroinfection is a worldwide concern and bacterial meningitis, tetanus and cerebral malaria have been reported as the commonest causes in developing countries. METHODS: From 1999 to 2007, all patients admitted to the Neurology Ward of Hospital das Clínicas, São Paulo University School of Medicine because of neuroinfection had their medical records reviewed. Age, gender, immunological status, neurological syndrome at presentation, infectious agent and clinical outcome were recorded. RESULTS: Three hundred and seventy four cases of neuroinfectious diseases accounted for 4.2% of ward admissions and the identification of infectious agent was successful in 81% of cases. Mean age was 40.5 + 13.4 years, 63.8% were male, 19.7% were immunocompromised patients and meningoencephalitis was the most common clinical presentation despite infectious agent. Viruses and bacteria were equally responsible for 29.4% of neuroinfectious diseases; parasitic, fungal and prion infections accounted for 28%, 9.6% and 3.5% respectively. Human immunodeficiency virus (HIV, herpes simplex virus 1 (HSV1, Mycobacterium tuberculosis, Treponema pallidum, Taenia solium, Schistosoma mansoni, Cryptococcus neoformans and Histoplasma capsulatum were the more common infectious pathogens in the patients. Infection mortality rate was 14.2%, of which 62.3% occurred in immunocompetent patients. CONCLUSION: Our institution appeared to share some results with developed and developing countries. Comparison with literature may be considered as quality control to health assistance.

Estudio histopatológico de 19 biopsias cutáneas de pacientes con sida e histoplasmosis diseminada

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Gerzaín Rodríguez

2001-06-01

Full Text Available La histoplasmosis diseminada (HD compromete la piel y la mucosa oronasofaríngea con alta frecuencia. Entre 1.800 enfermos con sida, 19 presentaron HD, todos con compromiso cutáneo o mucocutáneo. Las lesiones cutáneas fueron máculas, pápulas umbilicadas o escamocostrosas, nódulos y úlceras, en tanto que 42% de los pacientes presentaron ulceras orales. Las biopsias mostraron dermatitis perivasculares superficiales y profundas, nodulares y difusas, foliculitis pustulosa o vasculitis con PMN y leucocitoclasia, con cantidades variables del hongo, fagocitado por macrófagos. En 5 biopsias, Histoplasma ca~sulatums e vio dentro de los nervios cutáneos que estaban rodeados de inflamación variable o tenían perinervio desflecado y estaban invadidos por macrófagos con el hongo. Los principales diagnósticos diferenciales histológicos son: vasculitis leucocitoclásica, criptococosis, aftas, paracoccidioidomicosis y leishmaniasis difusa. Los clínicos, laboratoristas y patólogos deben tener en mente la HD en toda úlcera oral o erupción máculo-papular cutánea de pacientes con sida, pues el diagnóstico rápido de la micosis conduce a un tratamiento oportuno y eficaz, que controla la enfermedad. La biopsia es un procedimiento de diagnóstico rápido, seguro y confiable. H. capsulatum es capaz de invadir los nervios cutáneos.

Acquired immunodeficiency syndrome and its ocular complications

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Rao Narsing

1994-01-01

Full Text Available Human immunodeficiency virus infection is the first major pandemic of the 20th century. At present, almost 10 million people are known to be infected with this virus, and it is estimated that by the year 2000, approximately 40 million people will be infected. Transmission of this deadly infection is predominantly by sexual contact. Individuals infected with this virus pass through several predictable stages with progressive decrease in circulating CD4+ T cells. During the advanced stage, these patients develop various opportunistic infections or malignancies, or both. It is this advanced stage that was first recognized as AIDS, which has a 100% mortality rate. The opportunistic organisms that can involve the eye in patients with AIDS include cytomegalovirus, herpes zoster, Toxoplasma gondii, Mycobacterium tuberculosis, Cryptococcus neoformans, Mycobacterium avium-intracellulare, Pneumocystis carinii, Histoplasma capsulatum, Candida, and others. Intraocular lesions from these agents often represent disseminated infections. Visual morbidity occurs secondary to retinitis due to cytomegalovirus, herpes zoster, or Toxoplasma gondii. Anti-viral agents such as ganciclovir or foscarnet are effective against cytomegalovirus infection. The role of the ophthalmologist in the diagnosis and management of AIDS is becoming increasingly important. Not only does the eye reflect systemic disease, but ocular involvement may often precede systemic manifestations. In the AIDS patient, the ophthalmologist thus has an opportunity to make not only a slight-saving, but also life-saving diagnosis of disseminated opportunistic infections.

Encefalitis aguda: Manifestaciones neuropsiquiátricas como expresión de infección por virus de influenza Acute encephalitis: Neuropsychiatric manifestations as expression of influenza virus infection

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Noris Moreno-Flagge

2009-01-01

Full Text Available El objetivo fue revisar la encefalitis en niños y adolescentes, su etiología, manifestaciones clínicas, fisiopatología, métodos diagnósticos y tratamiento, enfatizando las manifestaciones neuropsiquiátricas de la encefalitis durante una epidemia de influenza. La encefalitis se considera una inflamación del sistema nervioso central (SNC que compromete el cerebro. Se manifiesta usualmente por cefaleas, fiebre y trastorno del estado de conciencia. Puede además manifestarse por convulsiones, cambios en la personalidad y manifestaciones obsesivas (síntomas neuropsiquiátricos. Las manifestaciones dependerán del tipo de virus y las células afectadas. La encefalitis puede ser causada por una gran variedad de agentes infecciosos incluyendo virus, bacterias, hongos y parásitos. Causas virales de encefalitis incluyen herpesvirus, arbovirus, rabia y enterovirus. Casos establecidos de bacterias incluyen Borrelia burgdorferi y rickettsia y el Mycoplasma neumoniae, al cual se atribuyen varios casos de encefalitis. Otros agentes como el hongo Coccidioides immitis e Histoplasma capsulatum pueden también generarla. Más de 100 agentes se han asociado a encefalitis. El diagnóstico de encefalitis constituye un reto para el clínico, y su etiología infecciosa usualmente se identifica entre el 40% al 70% de casos. El diagnóstico se hace con absoluta certeza sólo con una biopsia cerebral. La epidemiología depende de ciertos factores como la edad, la localización geográfica, la época del año, las condiciones climáticas y la inmunocompetencia del huésped. El tratamiento temprano puede disminuir el riesgo de muerte y las secuelas. Describimos cuatro pacientes con encefalitis y manifestaciones neuropsiquiátricas durante una epidemia de influenza, con el fin de alertar sobre esta asociación.The aim is to review the encephalitis in infants and adolescents as well as its etiology, clinical manifestation, epidemiology, physiopathology, diagnostic

Flavobacterium capsulatum

African Journals Online (AJOL)

long on the human skin surface. ... It produces septicaemia with serious lung and brain damage in the newborn, ... aches, tiredness and lack ofappetite, and lost IQ kg in weight. In ... globulin, complement and auto-antibody levels and full blood.

Firewood harvest from forests of the Murray-Darling Basin, Australia. Part 1: Long-term, sustainable supply available from native forests

International Nuclear Information System (INIS)

West, P.W.; Cawsey, E.M.; Stol, J.; Freudenberger, D.

2008-01-01

The Murray-Darling Basin is a 1 million km 2 agricultural region of south-eastern Australia, although 29% of it retains native forests. Some are mallee eucalypt types, whilst the 'principal' types are dominated mainly by other eucalypt species. One-third of the 6-7 million oven-dry tonne of firewood burnt annually in Australia is obtained from these forests, principally through collection of coarse woody debris. There are fears that removal of this debris may prejudice the floral and faunal biodiversity of the Basin. The present work considers what silvicultural management practices will allow the long-term maintenance of the native forests of the Basin and their continued contribution to its biodiversity. It then estimates that the maximum, long-term, annual, sustainable yield of firewood which could be harvested, by collection of coarse woody debris, from principal forest types of the Basin would be 10 million oven-dry tonne yr -1 . An alternative, harvest of firewood from live trees by thinning the principal forests and clear-felling mallee forests, would be able to supply 2.3 million tonne yr -1 sustainably. Whilst coarse woody debris harvests could supply far more than the present demand for firewood from the Basin, they would lead to substantial reductions of the debris remaining in the forests; this may be detrimental to biodiversity maintenance. Live tree harvest does not lead to this problem, but would barely be able to supply existing firewood demand

Emergence of epizootic ulcerative syndrome in native fish of the Murray-Darling River System, Australia: hosts, distribution and possible vectors.

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Craig A Boys

Full Text Available Epizootic ulcerative syndrome (EUS is a fish disease of international significance and reportable to the Office International des Epizootics. In June 2010, bony herring Nematalosa erebi, golden perch Macquaria ambigua, Murray cod Maccullochella peelii and spangled perch Leiopotherapon unicolor with severe ulcers were sampled from the Murray-Darling River System (MDRS between Bourke and Brewarrina, New South Wales Australia. Histopathology and polymerase chain reaction identified the fungus-like oomycete Aphanomyces invadans, the causative agent of EUS. Apart from one previous record in N. erebi, EUS has been recorded in the wild only from coastal drainages in Australia. This study is the first published account of A. invadans in the wild fish populations of the MDRS, and is the first confirmed record of EUS in M. ambigua, M. peelii and L. unicolor. Ulcerated carp Cyprinus carpio collected at the time of the same epizootic were not found to be infected by EUS, supporting previous accounts of resistance against the disease by this species. The lack of previous clinical evidence, the large number of new hosts (n = 3, the geographic extent (200 km of this epizootic, the severity of ulceration and apparent high pathogenicity suggest a relatively recent invasion by A. invadans. The epizootic and associated environmental factors are documented and discussed within the context of possible vectors for its entry into the MDRS and recommendations regarding continued surveillance, research and biosecurity are made.

Chest radiography for predicting the cause of febrile illness among inpatients in Moshi, Tanzania

International Nuclear Information System (INIS)

Fiorillo, S.P.; Diefenthal, H.C.; Goodman, P.C.; Ramadhani, H.O.; Njau, B.N.; Morrissey, A.B.; Maro, V.P.; Saganda, W.; Kinabo, G.D.; Mwako, M.S.; Bartlett, J.A.

2013-01-01

Aim: To describe chest radiographic abnormalities and assess their usefulness for predicting causes of fever in a resource-limited setting. Materials and methods: Febrile patients were enrolled in Moshi, Tanzania, and chest radiographs were evaluated by radiologists in Tanzania and the United States. Radiologists were blinded to the results of extensive laboratory evaluations to determine the cause of fever. Results: Of 870 febrile patients, 515 (59.2%) had a chest radiograph available; including 268 (66.5%) of the adolescents and adults, the remainder were infants and children. One hundred and nineteen (44.4%) adults and 51 (20.6%) children were human immunodeficiency virus (HIV)-infected. Among adults, radiographic abnormalities were present in 139 (51.9%), including 77 (28.7%) with homogeneous and heterogeneous lung opacities, 26 (9.7%) with lung nodules, 25 (9.3%) with pleural effusion, 23 (8.6%) with cardiomegaly, and 13 (4.9%) with lymphadenopathy. Among children, radiographic abnormalities were present in 87 (35.2%), including 76 (30.8%) with homogeneous and heterogeneous lung opacities and six (2.4%) with lymphadenopathy. Among adolescents and adults, the presence of opacities was predictive of Streptococcus pneumoniae and Coxiella burnetii, whereas the presence of pulmonary nodules was predictive of Histoplasma capsulatum and Cryptococcus neoformans. Conclusions: Chest radiograph abnormalities among febrile inpatients are common in northern Tanzania. Chest radiography is a useful adjunct for establishing an aetiologic diagnosis of febrile illness and may provide useful information for patient management, in particular for pneumococcal disease, Q fever, and fungal infections

Isolation, purification, and radiolabeling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients

International Nuclear Information System (INIS)

Klein, B.S.; Jones, J.M.

1990-01-01

No well-defined Blastomyces-specific antigens are currently available. We used sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting to identify immunologically active molecules in the cell wall of B. dermatitidis. A major immunoreactive 120-kD protein (WI-1) was present in all five strains studied and comprised 5% of the protein in the cell wall extract obtained after freezing and thawing yeast cells. WI-1 was recognized by serum from all 10 patients with blastomycosis but by none of those from 5 patients with histoplasmosis. It was purified by electroelution, radiolabeled with 125I, and incorporated into a radioimmunoassay (RIA) for serodiagnosis of blastomycosis. Antibody to WI-1 was detected in 58 (85%) of 68 patients with blastomycosis (geometric mean titer, 1:2,981), in two (3%) of 73 patients with histoplasmosis, coccidioidomycosis, sporotrichosis, or candidiasis (titers, 1:86 and 1:91) and in none of 44 healthy persons. WI-1 was shown to be a surface molecule abundant on B. dermatitidis yeasts that were indirectly stained with serum from a rabbit immunized with WI-1. Approximately 0.93 pg of WI-1 or 4.7 x 10(6) WI-1 molecules were found on the surface of an individual yeast using an antigen-inhibition RIA; none was found on Histoplasma capsulatum or Candida albicans yeasts. We conclude that WI-1 is a novel, immunologically active surface molecule on the invasive form of B. dermatitidis and that WI-1 can be used to reliably detect antibody and study the immunopathogenesis of blastomycosis

Isolation, purification, and radiolabeling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients

Energy Technology Data Exchange (ETDEWEB)

Klein, B.S.; Jones, J.M.

1990-01-01

No well-defined Blastomyces-specific antigens are currently available. We used sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting to identify immunologically active molecules in the cell wall of B. dermatitidis. A major immunoreactive 120-kD protein (WI-1) was present in all five strains studied and comprised 5% of the protein in the cell wall extract obtained after freezing and thawing yeast cells. WI-1 was recognized by serum from all 10 patients with blastomycosis but by none of those from 5 patients with histoplasmosis. It was purified by electroelution, radiolabeled with 125I, and incorporated into a radioimmunoassay (RIA) for serodiagnosis of blastomycosis. Antibody to WI-1 was detected in 58 (85%) of 68 patients with blastomycosis (geometric mean titer, 1:2,981), in two (3%) of 73 patients with histoplasmosis, coccidioidomycosis, sporotrichosis, or candidiasis (titers, 1:86 and 1:91) and in none of 44 healthy persons. WI-1 was shown to be a surface molecule abundant on B. dermatitidis yeasts that were indirectly stained with serum from a rabbit immunized with WI-1. Approximately 0.93 pg of WI-1 or 4.7 x 10(6) WI-1 molecules were found on the surface of an individual yeast using an antigen-inhibition RIA; none was found on Histoplasma capsulatum or Candida albicans yeasts. We conclude that WI-1 is a novel, immunologically active surface molecule on the invasive form of B. dermatitidis and that WI-1 can be used to reliably detect antibody and study the immunopathogenesis of blastomycosis.

Woman in Patriarchal Culture: Gender Discrimination and Intersectionality Portrayed in Bob Darling by Carolyn Cooke

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Ida Rosida

2017-05-01

Full Text Available This  article  examines  gender  discrimination,  and  investigates  the  relation  between  gender  and social  class  relation  experienced  by  the  main  female  character,  Carla,  in  the  short  story  entitled Bob Darling by Carolyn Cooke. The method used in this study is descriptive qualitative applying the  concept  of  gender  discrimination  by  Mansour  Fakih  and  the  concept  of  intersectionality  by Kimberlé Crenshaw about the connection of multiple dimensions, such as gender and class in making discrimination. This study aims to find how the main female character that lives in the patriarchal culture is depicted in the story. Moreover, it is to show how social segregation strengthens the gender discrimination.  Gender  discrimination  is  unjust  treatments  and  assumptions  against  someone, particularly based on a person’s sex that leads to the role that he or she should play in the society. The  different  role  however,  leads  to  the  harm  and  the  loss  of  person’s  right  in  life  especially  for woman who lives in patriarchal culture. The results show that stereotype, subordination and violence against woman are experienced by the main female character in the society as the effect of gender discrimination. Then, social class as a division of individual classes based on levels of individual’s position in society that can be determined by wealth, education, occupation, and others has a part in gender discrimination. When the woman is on lower class, she has less power and authority so that  it  makes  a  stronger  discrimination  against  her.  In  conclusion,  in  the  patriarchal  culture,  the discrimination against woman is not only influenced by the gender itself, but also the social class.DOI: 10.15408/insaniyat.v1i2.4345

HISTOPLASMIN SURVEY IN HIV-POSITIVE PATIENTS: RESULTS FROM AN ENDEMIC AREA IN NORTHEASTERN BRAZIL

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Fabricia Salvador Bezerra

2013-07-01

Full Text Available SUMMARY Background. Disseminated histoplasmosis is common in AIDS patients with advanced immunosuppression in Ceará, Northeastern Brazil. The goal of this study was to determine the prevalence of Histoplasma infection in patients with HIV/AIDS living in Fortaleza, the capital of Ceará. Methods. Intradermal tests with histoplasmin (mycelial phase were performed in 161 HIV patients with CD4 ≥ 350 cells/mm 3 . Evidence of recent illness was evaluated with immunodiffusion (ID tests in 76 of these individuals. Results. A total of 11.8% of patients reacted to histoplasmin and 2.63% had ID test positive to Histoplasma. The presence of mango trees (Mangifera indica in the patient neighborhood (OR = 2.870; 95% CI = 1.081-7.617; p = 0.040 and past activity involving soil (OR = 2.834; 95% CI = 1.045-7.687; p = 0.045 or visits to a farm (OR = 3.869; 95% CI = 1.189-12.591; p = 0.033 were significantly associated with Histoplasma infection. Conclusions. Patients with HIV living in Fortaleza have an expressive prevalence of infection with Histoplasma.

Media darling

CERN Multimedia

Chalmers, Matthew

2008-01-01

He is the media-friendly face of particle physics, appearing on countless TV and radio shows in the run-up to the opening of CERN's Large Hadron Collider. Matthew Chalmers discovers how Brian Cox finds the time to be both a physicist and a media personality. (2 pages)

Cellular and Molecular Defects Underlying Invasive Fungal Infections—Revelations from Endemic Mycoses

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Pamela P. Lee

2017-06-01

Full Text Available The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV, hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs. Dimorphic fungi such as Histoplasma capsulatum, Coccidioides spp., Paracoccidioides spp., Blastomyces dermatiditis, Sporothrix schenckii, Talaromyces (Penicillium marneffei, and Emmonsia spp. are geographically restricted to their respective habitats and cause endemic mycoses. Disseminated histoplasmosis, coccidioidomycosis, and T. marneffei infection are recognized as acquired immunodeficiency syndrome (AIDS-defining conditions, while the rest also cause high rate of morbidities and mortalities in patients with HIV infection and other immunocompromised conditions. In the past decade, a growing number of monogenic immunodeficiency disorders causing increased susceptibility to fungal infections have been discovered. In particular, defects of the IL-12/IFN-γ pathway and T-helper 17-mediated response are associated with increased susceptibility to endemic mycoses. In this review, we put together the various forms of endemic mycoses on the map and take a journey around the world to examine how cellular and molecular defects of the immune system predispose to invasive endemic fungal infections, including primary immunodeficiencies, individuals with autoantibodies against interferon-γ, and those receiving biologic response modifiers. Though rare, these conditions provide importance insights to host defense mechanisms against endemic fungi, which can only be appreciated in unique

Resource availability and competition shape the evolution of survival and growth ability in a bacterial community.

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Minna Pekkonen

Full Text Available Resource availability is one of the main factors determining the ecological dynamics of populations or species. Fluctuations in resource availability can increase or decrease the intensity of resource competition. Resource availability and competition can also cause evolutionary changes in life-history traits. We studied how community structure and resource fluctuations affect the evolution of fitness related traits using a two-species bacterial model system. Replicated populations of Serratia marcescens (copiotroph and Novosphingobium capsulatum (oligotroph were reared alone or together in environments with intergenerational, pulsed resource renewal. The comparison of ancestral and evolved bacterial clones with 1 or 13 weeks history in pulsed resource environment revealed species-specific changes in life-history traits. Co-evolution with S. marcescens caused N. capsulatum clones to grow faster. The evolved S. marcescens clones had higher survival and slower growth rate then their ancestor. The survival increased in all treatments after one week, and thereafter continued to increase only in the S. marcescens monocultures that experienced large resource pulses. Though adaptive radiation is often reported in evolution studies with bacteria, clonal variation increased only in N. capsulatum growth rate. Our results suggest that S. marcescens adapted to the resource renewal cycle whereas N. capsulatum was more affected by the interspecific competition. Our results exemplify species-specific evolutionary response to both competition and environmental variation.

Histoplasma skin test

Science.gov (United States)

Histoplasmosis skin test ... health care provider cleans an area of your skin, usually the forearm. An allergen is injected just below the cleaned skin surface. An allergen is a substance that causes ...

Lesson of the month 1: Lobar pulmonary consolidation in an immunocompromised host.

Science.gov (United States)

Reynolds, Daniel J; Andersen, Carl A; Hoskote, Sumedh S; Lee, Hee Eun; Raghunathan, Aditya; Kalra, Sanjay; Limper, Andrew H

2016-12-01

A 19-year-old male with a history of idiopathic panuveitis, currently taking methotrexate and infliximab, presented to our institution with 6 weeks of cough, dyspnoea and fevers. He had failed outpatient antimicrobial therapy. Computerised tomography (CT) of the chest revealed the presence of a lobar pneumonia and he was treated with broad spectrum antibiotics, which did not improve his symptoms. Bronchoalveolar lavage was performed with a transbronchial lung biopsy because of the diagnostic uncertainty of the patient's presentation. Pathology revealed non-budding yeasts, consistent with Pneumocystis Serological and urine studies were positive for both Histoplasma and Blastomyces The diagnosis of Histoplasma pneumonia was made because of the presentation being inconsistent with Pneumocystis pneumonia, and serology, urine and pathology testing being more consistent with Histoplasma The patient was treated with oral itraconazole and was doing well at follow-up 12 weeks after hospitalisation. © Royal College of Physicians 2016. All rights reserved.

Estudo da mcrobiota fúngica gastrintestinal de morcegos (Mammalia, Chiroptera da região noroeste do estado de São Paulo: potencial zoonótico

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Luciano Nery Tencate

2012-04-01

Full Text Available Os morcegos são hospedeiros de uma rica diversidade de microrganismos. Muitos trabalhos apontam uma estreita ligação entre quirópteros e fungos com potencial patogênico, principalmente por habitarem ambientes como cavernas, grutas e ocos de árvores, favoráveis à manutenção e propagação dos fungos. O objetivo do trabalho foi estudar a microbiota fúngica gastrintestinal de morcegos. Das 98 amostras pertencentes a 11 espécies de morcegos procedentes de 15 cidades estudadas, 20% são da espécie Carollia perspicillata, 19% Artibeus lituratus, 17% Molossus rufus, 13% Glossophaga soricina, 9% Nyctinomops macrotis, 8% Molossus molossus, 7% Desmodus rotundus, 2% Lasiurus ega, e 1% Eptesicus furinalis, Myotis nigricans e Tadarida brasiliensis. O gênero Aspergillus sp. foi isolado de 29% das amostras, seguidos por 6% Microsporum sp. e Penicillium sp., 4% Tricophyton sp. e zigomicetos e 2% Fusarium sp. Das espécies de leveduras, 14% foram de Rhodotorula sp., 10% Candida sp. e 2% Cryptococcus sp., 22% dos isolados permaneceram sem identificação. Todos os 82 cultivos de vísceras foram negativos para Histoplasma capsulatum. Houve associação estatística significativa entre os resultados do cultivo microbiológico e as espécies de morcegos (p < 0,05. Concluímos que os morcegos podem atuar como agentes veiculadores de fungos com potencial patogênico, entretanto outros trabalhos devem ser realizados a fim de estabelecer estratégias que permitam identificar os principais fatores correlacionados com o crescimento e a disseminação dos microrganismos na natureza e qual a implicação dos quirópteros no ciclo epidemiológico.

Quantifying water requirements of riparian river red gum (Eucalyptus camaldulensis) in the Murray-Darling Basin, Australia: Implications for the management of environmental flows

Science.gov (United States)

Doody, Tanya M.; Colloff, Matthew J.; Davies, Micah; Koul, Vijay; Benyon, Richard G.; Nagler, Pamela L.

2015-01-01

Water resource development and drought have altered river flow regimes, increasing average flood return intervals across floodplains in the Murray-Darling Basin, Australia, causing health declines in riparian river red gum (Eucalyptus camaldulensis) forests and woodlands. Environmental flow allocations helped to alleviate water stress during the recent Millennium Drought (1997–2010), however, quantification of the flood frequency required to support healthy E. camaldulensis communities is still needed. We quantified water requirements of E. camaldulensis for two years across a flood gradient (trees inundated at frequencies of 1:2, 1:5 and 1:10 years) at Yanga National Park, New South Wales to help inform management decision-making and design of environmental flows. Sap flow, evaporative losses and soil moisture measurements were used to determine transpiration, evapotranspiration and plant-available soil water before and after flooding. A formula was developed using plant-available soil water post-flooding and average annual rainfall, to estimate maintenance time of soil water reserves in each flood frequency zone. Results indicated that soil water reserves could sustain 1:2 and 1:5 trees for 15 months and six years, respectively. Trees regulated their transpiration rates, allowing them to persist within their flood frequency zone, and showed reduction in active sapwood area and transpiration rates when flood frequencies exceeded 1:2 years. A leaf area index of 0.5 was identified as a potential threshold indicator of severe drought stress. Our results suggest environmental water managers may have greater flexibility to adaptively manage floodplains in order to sustain E. camaldulensis forests and woodlands than has been appreciated hitherto.

Adaptive Management of Environmental Flows: Using Irrigation Infrastructure to Deliver Environmental Benefits During a Large Hypoxic Blackwater Event in the Southern Murray-Darling Basin, Australia

Science.gov (United States)

Watts, Robyn J.; Kopf, R. Keller; McCasker, Nicole; Howitt, Julia A.; Conallin, John; Wooden, Ian; Baumgartner, Lee

2018-03-01

Widespread flooding in south-eastern Australia in 2010 resulted in a hypoxic (low dissolved oxygen, DO) blackwater (high dissolved carbon) event affecting 1800 kilometres of the Murray-Darling Basin. There was concern that prolonged low DO would result in death of aquatic biota. Australian federal and state governments and local stakeholders collaborated to create refuge areas by releasing water with higher DO from irrigation canals via regulating structures (known as `irrigation canal escapes') into rivers in the Edward-Wakool system. To determine if these environmental flows resulted in good environmental outcomes in rivers affected by hypoxic blackwater, we evaluated (1) water chemistry data collected before, during and after the intervention, from river reaches upstream and downstream of the three irrigation canal escapes used to deliver the environmental flows, (2) fish assemblage surveys undertaken before and after the blackwater event, and (3) reports of fish kills from fisheries officers and local citizens. The environmental flows had positive outcomes; mean DO increased by 1-2 mg L-1 for at least 40 km downstream of two escapes, and there were fewer days when DO was below the sub-lethal threshold of 4 mg L-1 and the lethal threshold of 2 mg L-1 at which fish are known to become stressed or die, respectively. There were no fish deaths in reaches receiving environmental flows, whereas fish deaths were reported elsewhere throughout the system. This study demonstrates that adaptive management of environmental flows can occur through collaboration and the timely provision of monitoring results and local knowledge.

Estimates of evapotranspiration for riparian sites (Eucalyptus) in the Lower Murray -Darling Basin using ground validated sap flow and vegetation index scaling techniques

Science.gov (United States)

Doody, T.; Nagler, P. L.; Glenn, E. P.

2014-12-01

Water accounting is becoming critical globally, and balancing consumptive water demands with environmental water requirements is especially difficult in in arid and semi-arid regions. Within the Murray-Darling Basin (MDB) in Australia, riparian water use has not been assessed across broad scales. This study therefore aimed to apply and validate an existing U.S. riparian ecosystem evapotranspiration (ET) algorithm for the MDB river systems to assist water resource managers to quantify environmental water needs over wide ranges of niche conditions. Ground-based sap flow ET was correlated with remotely sensed predictions of ET, to provide a method to scale annual rates of water consumption by riparian vegetation over entire irrigation districts. Sap flux was measured at nine locations on the Murrumbidgee River between July 2011 and June 2012. Remotely sensed ET was calculated using a combination of local meteorological estimates of potential ET (ETo) and rainfall and MODIS Enhanced Vegetation Index (EVI) from selected 250 m resolution pixels. The sap flow data correlated well with MODIS EVI. Sap flow ranged from 0.81 mm/day to 3.60 mm/day and corresponded to a MODIS-based ET range of 1.43 mm/day to 2.42 mm/day. We found that mean ET across sites could be predicted by EVI-ETo methods with a standard error of about 20% across sites, but that ET at any given site could vary much more due to differences in aquifer and soil properties among sites. Water use was within range of that expected. We conclude that our algorithm developed for US arid land crops and riparian plants is applicable to this region of Australia. Future work includes the development of an adjusted algorithm using these sap flow validated results.

Transitions into and out of Teaching: A Longitudinal Analysis of Early Career Teacher Turnover

Science.gov (United States)

Perda, David

2013-01-01

There is widespread agreement among researchers and educators that teachers contribute to student learning (Darling-Hammond, 2002; Darling-Hammond; 2005; Ferguson, 1998; Goldhaber, 2003; Palardy and Rumberger, 2008; Rivkin, Hanushek, and Kain, 2005; Wright, Horn, and Sanders, 1997). In the face of teacher shortages and turnover, especially in hard…

DISSEMINATED HISTOPLASMOSIS DIAGNOSED ON BONE ...

African Journals Online (AJOL)

2009-12-02

Dec 2, 2009 ... Histoplasmosis, caused by two varieties of dimorphic fungi, Histoplasma ... from asymptomatic primary infection to disseminated disease in immunocompromised .... Addison's disease) tongue, gingivae, buccal mucosa,.

Testing Gone Amok: Leave No Teacher Candidate behind

Science.gov (United States)

Wepner, Shelley B.

2006-01-01

Teacher preparation, now acknowledged for its impact on K-12 student achievement (Darling-Hammond, 2000; Darling-Hammond, Berry, & Thoreson, 2000), needs to be part of the discussions about ways to address emerging issues with testing and accountability. What then do teacher educators who work with those preparing to teach do to guide their…

Three Phoma spp. synthesised novel silver nanoparticles that possess excellent antimicrobial efficacy.

Science.gov (United States)

Rai, Mahendra; Ingle, Avinash P; Gade, Aniket K; Duarte, Marta Cristina Teixeira; Duran, Nelson

2015-10-01

The authors report extracellular mycosynthesis of silver nanoparticles (AgNPs) by Phoma capsulatum, Phoma putaminum and Phoma citri. The AgNPs thus synthesised were characterised by UV-visible spectrophotometer, Fourier transform infrared spectroscopy, Nanosight LM20 and transmission electron microscopy, which confirmed the synthesis of mostly spherical and polydisperse nanoparticles capped with proteins. The size of AgNPs was found in the range of 10-80 , 5-80 and 5-90 nm with an average size of 31.85, 25.43 and 23.29 nm by P. capsulatum, P. putaminum and P. citri, respectively. Further, potential antimicrobial activity was reported against Aspergillus niger, Candida albicans, Salmonella choleraesuis, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. The lowest minimal inhibitory concentration (MIC) (0.85 µg/ml) was reported for AgNPs synthesised from P. citri against S. choleraesuis. However, AgNPs synthesised from P. capsulatum showed the highest MIC (10.62 µg/ml) against S. choleraesuis, P. aeruginosa and E. coli (clinical isolate). The same MIC values (10.62 µg/ml) were also reported against P. aeruginosa and both clinical and standard isolates of E. coli for AgNPs synthesised from P. citri. It was also observed that all the silver nanoparticles showed remarkable antifungal and antibacterial activity against these tested pathogens as compared with the commercially available antifungal and antibacterial agents.

Kiirusta, Murray-Darling / Robert Milliken

Index Scriptorium Estoniae

Milliken, Robert

2009-01-01

Veehulk Murray-Darlingu jõestikus, mis varustab veega seitsmendikku Austraaliast, on vähenemas ning veevarustuse säilimise eest peab hakkama võitlema peaminister Kevin Ruddi juhitud valitsus. Kaart

Evaluation of antagonistic fungi against charcoal rot of sunflower ...

African Journals Online (AJOL)

In vitro, sensitivity of Macrophomina phaseolina (Tassi) Goid determined through inhibition zone technique to various antagonistic fungi viz., Aspergillus niger, Aspergillus flavus, Trichoderma viride, Trichoderma harzianum and Penicillium capsulatum amended into PDA medium. All the antagonists reduced the colony ...

Comparative genomics allowed the identification of drug targets against human fungal pathogens

Directory of Open Access Journals (Sweden)

Martins Natalia F

2011-01-01

Full Text Available Abstract Background The prevalence of invasive fungal infections (IFIs has increased steadily worldwide in the last few decades. Particularly, there has been a global rise in the number of infections among immunosuppressed people. These patients present severe clinical forms of the infections, which are commonly fatal, and they are more susceptible to opportunistic fungal infections than non-immunocompromised people. IFIs have historically been associated with high morbidity and mortality, partly because of the limitations of available antifungal therapies, including side effects, toxicities, drug interactions and antifungal resistance. Thus, the search for alternative therapies and/or the development of more specific drugs is a challenge that needs to be met. Genomics has created new ways of examining genes, which open new strategies for drug development and control of human diseases. Results In silico analyses and manual mining selected initially 57 potential drug targets, based on 55 genes experimentally confirmed as essential for Candida albicans or Aspergillus fumigatus and other 2 genes (kre2 and erg6 relevant for fungal survival within the host. Orthologs for those 57 potential targets were also identified in eight human fungal pathogens (C. albicans, A. fumigatus, Blastomyces dermatitidis, Paracoccidioides brasiliensis, Paracoccidioides lutzii, Coccidioides immitis, Cryptococcus neoformans and Histoplasma capsulatum. Of those, 10 genes were present in all pathogenic fungi analyzed and absent in the human genome. We focused on four candidates: trr1 that encodes for thioredoxin reductase, rim8 that encodes for a protein involved in the proteolytic activation of a transcriptional factor in response to alkaline pH, kre2 that encodes for α-1,2-mannosyltransferase and erg6 that encodes for Δ(24-sterol C-methyltransferase. Conclusions Our data show that the comparative genomics analysis of eight fungal pathogens enabled the identification of

Effects of variations in flow characteristics through W.P. Franklin Lock and Dam on downstream water quality in the Caloosahatchee River Estuary and in McIntyre Creek in the J.N. “Ding” Darling National Wildlife Refuge, southern Florida, 2010–13

Science.gov (United States)

Booth, Amanda C.; Soderqvist, Lars E.; Knight, Travis M.

2016-05-17

The U.S. Geological Survey studied water-quality trends at the mouth of McIntyre Creek, an entry point to the J.N. “Ding” Darling National Wildlife Refuge, to investigate correlations between flow rates and volumes through the W.P. Franklin Lock and Dam and water-quality constituents inside the refuge from March 2010 to December 2013. Outflow from Lake Okeechobee, and flows from Franklin Lock, tributaries to the Caloosahatchee River Estuary, and the Cape Coral canal system were examined to determine the sources and quantity of water to the study area. Salinity, temperature, dissolved-oxygen concentration, pH, turbidity, and chromophoric dissolved organic matter fluorescence (FDOM) were measured during moving-boat surveys and at a fixed location in McIntyre Creek. Chlorophyll fluorescence was also recorded in McIntyre Creek. Water-quality surveys were completed on 20 dates between 2011 and 2014 using moving-boat surveys.Franklin Lock contributed the majority of flow to the Caloosahatchee River. Between 2010 and 2013, the monthly mean flow rate at Franklin Lock ranged from 29 cubic feet per second in May 2011 to 10,650 cubic feet per second in August 2013. Instantaneous near-surface salinity in McIntyre Creek ranged from 12.9 parts per thousand on September 26, 2013, to 37.9 parts per thousand on June 27, 2011. Salinity in McIntyre Creek decreased with increasing flow rate through Franklin Lock. Flow rates through Franklin Lock explained 61 percent of the variation in salinity in McIntyre Creek. Salinity data from moving-boat surveys also indicate that an increase in flow rate at Franklin Lock decreases salinity in the Caloosahatchee River Estuary, and a reduction or elimination in flow increases salinity. The FDOM in McIntyre Creek was positively correlated with flow at Franklin Lock, and 54 percent of the variation in FDOM can be attributed to the flow rate through Franklin Lock. Data from moving-boat surveys indicate that FDOM increases when flow volume from

CASE REPORT: Histoplasmosis of Paranasal Sinuses and Orbit: A ...

African Journals Online (AJOL)

Fungal sinusitis is a known cause of persistent or chronic sinusitis. Various authors have reported various fungal organisms such as aspergillus species, candida species and phycomycetes but not histoplasma duboisii as the cause of fungal sinusitis. A rare case of facial deformity secondary to invasive fungal infection by ...

Multiparameter probability distributions for heavy rainfall modeling in extreme southern Brazil

Directory of Open Access Journals (Sweden)

Samuel Beskow

2015-09-01

New hydrological insights for the region: The Anderson–Darling and Filliben tests were the most restrictive in this study. Based on the Anderson–Darling test, it was found that the Kappa distribution presented the best performance, followed by the GEV. This finding provides evidence that these multiparameter distributions result, for the region of study, in greater accuracy for the generation of intensity–duration–frequency curves and the prediction of peak streamflows and design hydrographs. As a result, this finding can support the design of hydraulic structures and flood management in river basins.

El capitalismo rentístico Elementos cuantitativos de la economía venezolana

OpenAIRE

Baptista, Asrúbal

2005-01-01

Desde 1920, la economía venezolana descansa sobre una estructura cuyo principal determinante es la renta del petróleo. Cabe así hablar, para darle un nombre propio, de capitalismo rentístico. Con el apoyo primario de una definición operativa de la renta petrolera que permite la introducción de un nuevo concepto contable, el producto interno bruto no rentístico, aquí se buscar darle su caracterización cuantitativa en términos de ciertos indicadores especialmente relevantes, a saber: la relació...

A 30 m Resolution Surface Water Mask Including Estimation of Positional and Thematic Differences Using Landsat 8, SRTM and OpenStreetMap: A Case Study in the Murray-Darling Basin, Australia

Directory of Open Access Journals (Sweden)

Gennadii Donchyts

2016-05-01

Full Text Available Accurate maps of surface water are essential for many environmental applications. Surface water maps can be generated by combining measurements from multiple sources. Precise estimation of surface water using satellite imagery remains a challenging task due to the sensor limitations, complex land cover, topography, and atmospheric conditions. As a complementary dataset, in the case of hilly landscapes, a drainage network can be extracted from high-resolution digital elevation models. Additionally, Volunteered Geographic Information (VGI initiatives, such as OpenStreetMap, can also be used to produce high-resolution surface water masks. In this study, we derive a high-resolution water mask using Landsat 8 imagery and OpenStreetMap as well as (potential a drainage network using 30 m SRTM. Our approach to derive a surface water mask from Landsat 8 imagery comprises the use of a lower 15% percentile of Landsat 8 Top of Atmosphere (TOA reflectance from 2013 to 2015. We introduce a new non-parametric unsupervised method based on the Canny edge filter and Otsu thresholding to detect water in flat areas. For hilly areas, the method is extended with an additional supervised classification step used to refine the water mask. We applied the method across the Murray-Darling basin, Australia. Differences between our new Landsat-based water mask and the OpenStreetMap water mask regarding positional differences along the rivers and overall coverage were analyzed. Our results show that about 50% of the OpenStreetMap linear water features can be confirmed using the water mask extracted from Landsat 8 imagery and the drainage network derived from SRTM. We also show that the observed distances between river features derived from OpenStreetMap and Landsat 8 are mostly smaller than 60 m. The differences between the new water mask and SRTM-based linear features and hilly areas are slightly larger (110 m. The overall agreement between OpenStreetMap and Landsat 8 water

Performance of Jatropha curcas L. in Semi-arid Zone: Seed Germination, Seedling Growth and Early Field Growth

Directory of Open Access Journals (Sweden)

Sharif AHAMAD

2013-05-01

Full Text Available There is a lack of information on basic agronomic properties of Jatropha curcas L. (jatropha cultivation on the marginal lands in the semi-arids. Evaluation of agronomic performance of identified elite strains of J. curcas in marginal lands would be of paramount importance for addressing gap areas in their agronomic properties and subsequently for harnessing their optimum economic potentials. The present study undertook the task of analysing the growth performance of a high oil bearing elite strain of J. curcas–DARL-2 in degraded land in semi-arid zone of Deccan Plateau, India. While undertaking the assessment of growth performance of elite strain DARL-2, two other native (wild strains (namely AHN-1 and AHN-2 of J. curcas were also considered so that a comparative evaluation could be carried out. The role of gypsum was also investigated on J. curcas in the nursery stage as well its carry over effects on growth performance of transplanted trees in the field. Two types of substrates, gypsum-treated soil (GS and untreated soil (SL were used for growing seedlings of all the three jatropha strains. Seedlings (120-days-old of DARL-2 exhibited greater plant height, collar diameter and number of branches but root length was greater in the local strains. In the second year of field transplantation, DARL-2 strain exhibited significantly (p<0.05 greater plant height and number of branches/plant. No carry over effects of gypsum treatment were observed in field transplanted plants as none of the growth parameters significantly varied among the substrate types.

Role of fluconazole in the long-term suppressive therapy of fungal infections in patients with artificial implants.

Science.gov (United States)

Penk, A; Pittrow, L

1999-12-01

With the increased use of artificial implants the management of related infections has become an important challenge. Normally an infected implant would be removed. In many cases this might be contraindicated and drug treatment remains as the only alternative. As microbiological eradication is often impossible, especially in fungal infections at artificial implants (FIAI) long-term suppressive therapy might be required. The objective of this study was to determine the therapeutic value of fluconazole (F) in the management of FIAI. Clinical data of 56 patients (pts) with proven or suspected fungal infections and artificial implants (FIAI) subsequently treated with F were analyzed retrospectively. FIAI caused by species with intrinsic resistance to F have been excluded from the study. The following implants were involved: prosthetic valve endocarditis (PVE) 25 pts (44.6%), intraocular lenses (IL) 9 pts (16.1%), ventriculoperitoneal shunts (VPS) 6 pts (10.7%), knee prostheses (KP) 5 pts (8.9%), biliary stents (BS) 4 pts (7.1 %), venous access devices (VAS) 3 pts (5.4%), urinary stents (US) 2 pts (3.6%), breast implant and pacemaker 1 patient (1.8%) each. Underlying diseases were valve insufficiency (in PVE), cataract surgery (in IL), prematurity in newborns (in VPS), arthrosis (in KP), biliary obstruction (in BS), cystic fibrosis (in VAS), and obstructive renal calculi (in US). Candida species (C. spp.) were the most frequently detected causative agents with C. parapsilosis as the leading cause (n = 19; 33.9%). Furthermore C. albicans (n = 15; 26.8%), C. spp. and fungi not further specified (n = 8; 14.3%), C. tropicalis (n = 3; 5.4%), C. glabrata (n = 3; 5.4%), and C. lusitaniae (n = 1; 1.8%) were identified. Acremonium kiliense has been detected in 4 pts (7.1%), Cryptococcus neoformans in 2 pts (3.6 %). Histoplasma capsulatum was identified in 1 patient (1.8%). The maximum duration of treatment with F was lifelong with a maximum recorded duration of 4,5 years. The

The measurement of thoron concentrations in Australia using the Japanese passive R-T dosimeter

International Nuclear Information System (INIS)

Toussaint, L.F.; Tokonami, S.; Doi, M.; Solomon, S.B.; Peggie, J.R.

1998-01-01

Previous studies have shown higher gamma radiation levels and higher soil thorium concentrations in the Darling Scarp area to the east of the city of Perth in Western Australia. It was considered desirable to measure the concentrations of the 220 Rn (thoron) in houses built near such areas and compare these measurements with similar measurements at other sites within Australia. A monitor developed for surveying 220 Rn and 222 Rn levels in Japan was considered most suitable for this purpose. The monitor used for the survey was a passive radon-thoron discriminative dosimeter, similar in type to that used to measure thoron concentrations in traditional Japanese houses. Houses for this study were selected from areas in the Darling Scarp. To provide data on what might be considered typical thoron concentrations associated with other soil types within Australia, a small number of houses in areas on the coastal plain of Western Australia and from the coastal areas of Victoria were also monitored. The mean thoron concentration in homes on the Darling Scarp of 14.0 Bq.m -3 was higher than that in the coastal plain in Western Australia (3.0 Bq.m -3 ) but comparable to the measurements in Victoria (11.3 Bq.m -3 ). For the radon measurements in homes, the mean Scarp concentration was typically 49.2 Bq.m -3 while the WA coastal plain and in Victoria mean concentrations were 11.6 Bq.m -3 and 15.4 Bq.m -3 respectively. For outdoors in the Darling Scarp, the thoron mean was 76.3 Bq.m -3 while the radon level was 18.2 Bq.m -3 . These measurements would suggest that the source of the thoron in homes on the Scarp is from the underlying soil rather than from the building materials. (author)

Goodness-of-fit tests for the Gompertz distribution

DEFF Research Database (Denmark)

Lenart, Adam; Missov, Trifon

The Gompertz distribution is often fitted to lifespan data, however testing whether the fit satisfies theoretical criteria was neglected. Here five goodness-of-fit measures, the Anderson-Darling statistic, the Kullback-Leibler discrimination information, the correlation coefficient test, testing ...... for the mean of the sample hazard and a nested test against the generalized extreme value distributions are discussed. Along with an application to laboratory rat data, critical values calculated by the empirical distribution of the test statistics are also presented.......The Gompertz distribution is often fitted to lifespan data, however testing whether the fit satisfies theoretical criteria was neglected. Here five goodness-of-fit measures, the Anderson-Darling statistic, the Kullback-Leibler discrimination information, the correlation coefficient test, testing...

Selling “Performance” Assessments with Inaccurate Pictures from Kentucky

Directory of Open Access Journals (Sweden)

Richard G. Innes

2015-02-01

Full Text Available A new white paper from Ace Parsi and Linda Darling-Hammond, “Performance Assessments: How State Policy Can Advance Assessments for 21st Century Learning,” has a discussion on Page 7 about supposed success of the Kentucky Instructional Results Information System (KIRIS used in that state from 1992 to 1998. This discussion paper explains the numerous problems with that description. The Kentucky-related comments in the Parsi/Darling-Hammond paper claim a basis in a technical report titled “Commonwealth Accountability and Testing System: 2007–08 Technical report, Version 1.2” created by Measured Progress in 2009. Unfortunately, the Kentucky Department of Education recently redesigned its web site and this technical report is no longer online. However, if the report actually does show the information attributed to it by Parsi and Darling-Hammond, that information is incorrect. Of course, as a closeout epitaph of yet another failure, Kentucky’s now failed Commonwealth Accountability Testing System (CATS, which succeeded the failed KIRIS system, the 2007-08 technical report may not have received an appropriate level of attention to detail. The comments below are referenced to reports issued during or shortly after the events occurred and are known to this long-time Kentucky resident to present an accurate picture.

How should agriculture adapt to worrying but uncertain information from climate science?

Energy Technology Data Exchange (ETDEWEB)

Hayman, P. [Climate Change Risk and Vulnerability, Allen Consulting Group, Melbourne (Australia)

2006-02-15

Overview of the impacts, adaptive capacity and vulnerability at crop, farm, industry and community level in the agricultural sector of the Murray-Darling basin and other key Australian agricultural areas.

Täna kell 20 esitletakse EKA galerii...

Index Scriptorium Estoniae

2004-01-01

Esitletakse norra kunstnike (loetletud) videosid "Darling, don't leave me all by myself". Korraldaja Bergeni kuraatoriduo Rakett (Asa Lövgren, Karolin Tampere). 4. IV näeb Tallinna projekti Von Krahli teatris

Modified Anderson-Darling tests with selective power improvement

OpenAIRE

Cabaña Nigro, Alejandra

2001-01-01

Transformed empirical processes (TEPs) have been used by the authors in a previous paper to construct consistent and selectively efficient goodness-of-fit tests of the Kolmogorov-Smirnov type. A straightforward application of the same ideas to the construction of tests of the Cramér-von-Mises type with the same properties leads to cumbersome computations. This short note of the incovenients encountered, and introduces a new family of quadratic statistics of the Cramér-von Mises type, in order...

Siim Nestor soovitab : Tallinn Doom Night vol.1. Odessa Pop / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Soome doom-metal ansambel Reverend Bizarre üritusel "Tallinn Doom Night vol.1" 8. dets. klubis Rockstar's. Indipoppi viljelev Rootsi duo My Darling Yoy! üritusel "Odessa Pop" 9. dets. Tallinnas klubis KuKu

78 FR 30872 - Marine Mammals; File Nos. 14451, 14353, and 13846

Science.gov (United States)

2013-05-23

... Organization, 11 Des Isle Ave Bar Harbor, ME 04609; and Jim Darling, Ph.D., Whale Trust, P.O. Box 384, Tofino... geographic area throughout the Hawaiian Islands, including the Northwestern Hawaiian Islands chain. Permit No...

Plaadid / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2004-01-01

Uutest heliplaatidest Travis "Singles", Talking Heads "The Best Of", The Hidden Cameras "Mississauga Goddam", Aberfeldy "Young Forever", The Music "Welcome To The North", Bitch Alert "Kill Your Darlings", Manic Street Preachers "Lifeblood", Depeche Mode "Remixes81-04"

Isotope Effects Associated with N2O Production by Fungal and Bacterial Nitric Oxide Reductases: Implications for Enzyme Mechanisms

Science.gov (United States)

Hegg, E. L.; Yang, H.; Gandhi, H.; McQuarters, A.; Lehnert, N.; Ostrom, N. E.

2014-12-01

Nitrous oxide (N2O) is both a powerful greenhouse gas and a key participant in ozone destruction. Microbial activity accounts for over 70% of the N2O produced annually, and the atmospheric concentration of N2O continues to rise. Because the fungal and bacterial denitrification pathways are major contributors to microbial N2O production, understanding the mechanism by which NO is reduced to N2O will contribute to both N2O source tracing and quantification. Our strategy utilizes stable isotopes to probe the enzymatic mechanism of microbial N2O production. Although the use of stable isotopes to study enzyme mechanisms is not new, our approach is distinct in that we employ both measurements of isotopic preferences of purified enzyme and DFT calculations, thereby providing a synergistic combination of experimental and computational approaches. We analyzed δ18O, δ15Nα (central N atom in N2O), and δ15Nβ (terminal N atom) of N2O produced by purified fungal cytochrome P450 nitric oxide reductase (P450nor) from Histoplasma capsulatum as well as bacterial cytochrome c dependent nitric oxide reductase (cNOR) from Paracoccus denitrificans. P450nor exhibits an inverse kinetic isotope effect for Nβ (KIE = 0.9651) but a normal isotope effect for both Nα (KIE = 1.0127) and the oxygen atom (KIE = 1.0264). These results suggest a mechanism where NO binds to the ferric heme in the P450nor active site and becomes Nβ. Analysis of the NO-binding step indicated a greater difference in zero point energy in the transition state than the ground state, resulting in the inverse KIE observed for Nβ. Following protonation and rearrangement, it is speculated that this complex forms a FeIV-NHOH- species as a key intermediate. Our data are consistent with the second NO (which becomes Nα and O in the N2O product) attacking the FeIV-NHOH- species to generate a FeIII-N2O2H2 complex that enzymatically (as opposed to abiotically) breaks down to release N2O. Conversely, our preliminary data

A Tale of Two Gases: Isotope Effects Associated with the Enzymatic Production of H2 and N2O

Science.gov (United States)

Yang, H.; Gandhi, H.; Kreuzer, H. W.; Moran, J.; Hill, E. A.; McQuarters, A.; Lehnert, N.; Ostrom, N. E.; Hegg, E. L.

2014-12-01

Stable isotopes can provide considerable insight into enzymatic mechanisms and fluxes in various biological processes. In our studies, we used stable isotopes to characterize both enzyme-catalyzed H2 and N2O production. H2 is a potential alternative clean energy source and also a key metabolite in many microbial communities. Biological H2 production is generally catalyzed by hydrogenases, enzymes that combine protons and electrons to produce H2 under anaerobic conditions. In our study, H isotopes and fractionation factors (α) were used to characterize two types of hydrogenases: [FeFe]- and [NiFe]-hydrogenases. Due to differences in the active site, the α associated with H2 production for [FeFe]- and [NiFe]-hydrogenases separated into two distinct clusters (αFeFe > αNiFe). The calculated kinetic isotope effects indicate that hydrogenase-catalyzed H2 production has a preference for light isotopes, consistent with the relative bond strengths of O-H and H-H bonds. Interestingly, the isotope effects associated with H2 consumption and H2-H2O exchange reactions were also characterized, but in this case no specific difference was observed between the different enzymes. N2O is a potent greenhouse gas with a global warming potential 300 times that of CO2, and the concentration of N2O is currently increasing at a rate of ~0.25% per year. Thus far, bacterial and fungal denitrification processes have been identified as two of the major sources of biologically generated N2O. In this study, we measured the δ15N, δ18O, δ15Nα (central N atom in N2O), and δ15Nβ (terminal N atom in N2O) of N2O generated by purified fungal P450 nitric oxide reductase (P450nor) from Histoplasma capsulatum. We observed normal isotope effects for δ18O and δ15Nα, and inverse isotope effects for bulk δ15N (the average of Nα and Nβ) and δ15Nβ. The observed isotope effects have been used in conjunction with DFT calculations to provide important insight into the mechanism of P450nor. Similar

Life history and habitat preference in the Darling hardyhead, Craterocephalus amniculus (Teleostei, Atherinidae) in the northern Murray-Darling Basin, Australia

DEFF Research Database (Denmark)

Moy, Karl G.; Wilson, G. Glenn; Ellison, Tanya L.

2018-01-01

and spatial variation in diet, and habitat selection in this species across multiple sites and years in the upper Macintyre River, northern New South Wales. Preserved specimens from a separate study were used to obtain information on diet and size structure. Size structures suggested a single annual spawning...... most of the diet while over half the gut contents at the downstream site was unidentified detritus. Preference was shown for pool habitats with a sand or cobble substrate, increased channel depth and width and distance from the bank, and reduced flow velocity. Overhanging exotic riparian vegetation...

Maternal and perinatal outcome of patients with severe pre ...

African Journals Online (AJOL)

ABEOLUGBENGAS

Eclampsia occurred in 3 members of the diazepam group and none in the MgSO group. There were no .... in pre-eclampsia- abnormal trophoblastic invasion of uterine blood vessels and endothelial cell ..... O'Brien E, Conroy R & Darling MR.

Using technology to scaffold progressive teaching

DEFF Research Database (Denmark)

Bundsgaard, Jeppe

2018-01-01

An encouraging consensus has arisen in recent decades among researchers and policy organizations in favor of more progressive teaching practices like Inquiry Based Science Education (B. Barron & Darling-Hammond, 2010; Rocard et al., 2007) and Project Based Learning (Krajcik & Shin, 2014; OECD Pub...

La identidad caribe en los 12 cuentos peregrinos.

OpenAIRE

Herrera Molina, Luis Carlos

2014-01-01

En un análisis tentativo sobre los Cuentos Peregrinos aparece una obsesión que trasciende la totalidad de estos cuentos: la identidad latinoamericana. Aspecto que queremos resaltar, para lo cual partimos de la posibilidad de darles una interpretación global.

The Poor Don’t Need Another Prophet: A People-Centered Approach to Microfinance and Education in Bolivia

NARCIS (Netherlands)

P.A. Arora (Payal)

2006-01-01

textabstractIntroduction: As international aid agencies increasingly embrace microfinance, the darling of international development, questions are beginning to surface. Who benefits from this savings and lending system that claims to target the poor? Does an increase in social capital of the poor

The influence of climate variability on numbers of three waterbird species in Western Port, Victoria, 1973 2002

Science.gov (United States)

Chambers, Lynda E.; Loyn, Richard H.

2006-05-01

Seasonal and annual movements of Australian waterbirds are generally more complex than those of their Northern Hemisphere counterparts, and long-term data are needed to understand their relationships with climatic variables. This paper explores a long-term (1973 2002) set of waterbird counts from coastal Victoria and relates them to climatic data at local and continental scales. Three species (Black Swan Cygnus atratus, White-faced Heron Egretta novaehollandiae and Grey Teal Anas gracilis) were chosen for this analysis. Black Swans have large local breeding populations near the study region; White-faced Herons have smaller local breeding populations and Grey Teal breed extensively in ephemeral inland floodplains, such as those in the Murray-Darling Basin. All showed significant relationships with streamflow, regional rainfall and the Southern Oscillation Index (SOI) at appropriate scales and time-lags, with streamflow explaining the most variance. Black Swans showed a strong seasonal cycle in abundance and local climate variables had the greatest influence on the counts. Numbers were positively correlated with streamflow in southern Victoria three to six seasons before each count. Broader-scale climatic patterns were more important for the other two species. Numbers of White-faced Herons were positively correlated with streamflow or rainfall over various parts of Australia seven to nine seasons before each count. Numbers of Grey Teal showed weak seasonal cycles, and were negatively correlated with rainfall in Victoria or the Murray-Darling Basin in the seasons before or during each count, and positively with streamflow in the Murray-Darling Basin 15 18 months before each count.

Generating new telehealth services using a whole of community approach: experience in regional Queensland.

Science.gov (United States)

Smith, Anthony C; Caffery, Liam J; Saunders, Ruth; Bradford, Natalie K; Gray, Leonard C

2014-10-01

We implemented a community telehealth project in the three towns in the Darling Downs area of Queensland over a 2-year period starting in July 2012. The purpose of the project was to generate telehealth activity in hospitals, general practice and selected residential aged care facilities. Telehealth education and training was provided to clinicians in the three towns and a community awareness campaign was delivered using advertisements in newspapers, messages in social media and presentations at community events. A total of 55 stakeholders were engaged with during 61 site visits to health care facilities during the first two years of the project. During the study period, telehealth activity in Queensland increased in the hospital sector by 39% and in the non-hospital sector by 99%. In the Darling Downs region, telehealth activity in the hospital sector increased by 104%, compared to 28% in the rest of Queensland. However, in the non-hospital sector, the increase in telehealth activity in the Darling Downs region was similar to the rest of Queensland. Telehealth services established and/or facilitated by the project included specialist geriatric ward rounds in Dalby, Chinchilla and Miles for patients in the local hospitals and nursing homes; and ad-hoc teleconsultations for children and adults living in these communities, with specialists at Toowoomba and hospitals in Brisbane. An increase in telehealth implies better access to a range of clinical services, which may result in improved clinical outcomes for patients. © The Author(s) 2014 Reprints and permissions:]br]sagepub.co.uk/journalsPermissions.nav.

A comparison of changes in river runoff from multiple global and catchment-scale hydrological models under global warming scenarios of 1 °C, 2 °C and 3 °C

NARCIS (Netherlands)

Gosling, S.N.; Zaherpour, J.J.; Mount, N.J.; Hattermann, F.F.; Dankers, R.; Arheimer, B.; Breuer, L.; Ding, J.; Haddeland, I.; Kumar, R.; Kundu, D.; Liu, J.; van Griensven, A.; Veldkamp, T.I.E.; Vetter, T.; Wang, X.; Zhang, X.

2017-01-01

We present one of the first climate change impact assessments on river runoff that utilises an ensemble of global hydrological models (Glob-HMs) and an ensemble of catchment-scale hydrological models (Cat-HMs), across multiple catchments: the upper Amazon, Darling, Ganges, Lena, upper Mississippi,

Engaging Second-Stage Teachers in Their Work: The Role of Professional Culture in Schools

Science.gov (United States)

Kirkpatrick, Cheryl Lynne

2009-01-01

Educational researchers acknowledge that teachers make a difference in the educational outcomes of youth (Boyd, Lankford, Loeb, Rockoff, & Wyckoff, 2008; Darling-Hammond, 2000; Hanushek, 1992; Hanushek & Rivkin, 2007; Johnson, 2006; Sanders & Rivers, 1996; Sanders & Horn, 1998). However, staffing schools with qualified teachers has proven…

From Good to Great: Exemplary Teachers Share Perspectives on Increasing Teacher Effectiveness across the Career Continuum

Science.gov (United States)

Behrstock-Sherratt, Ellen; Bassett, Katherine; Olson, Derek; Jacques, Catherine

2014-01-01

For well over a decade, teachers have been recognized as the single most important school-level factor influencing student achievement (Darling-Hammond, 2000; McCaffrey, Lockwood, Koretz, & Hamilton, 2003; Rivkin, Hanushek, & Kain, 2000; Rowan, Correnti & Miller, 2002; Wright, Horn, & Sanders, 1997). Tremendous public resources…

Reciprocal Relations between Perceived Parental Knowledge and Adolescent Substance Use and Delinquency: The Moderating Role of Parent-Teen Relationship Quality

Science.gov (United States)

Abar, Caitlin C.; Jackson, Kristina M.; Wood, Mark

2014-01-01

The current study prospectively examined hypothesized short- and long-term reciprocal relations between perceived parental knowledge and adolescent heavy episodic drinking, marijuana use, and delinquency. Using the contextual model of parenting style (Darling & Steinberg, 1993), we examined the extent to which the bidirectional nature of…

Paradox or Prudence? Analyzing the Coherence of the US’ China Strategy

Science.gov (United States)

2013-06-01

transitioned from being America’s darling reforming communist country to being its poster child for communist repression, the Soviet Bloc (and soon afterward...http://www.globaltimes.cn/NEWS/tabid/99/ID/680694/ Dont - take-peaceful-approach-for-granted.aspx (accessed February 22, 2013). Kanter, James. "Wen

We still love SUSY

Energy Technology Data Exchange (ETDEWEB)

Anon.

1992-11-15

Supersymmetry, affectionately known as SUSY, is still the darling of theoretical particle physics. Invented some 20 years ago, the charismatic idea really took off at the beginning of the 1980s. At the time, a workshop at CERN reflected the youthful enthusiasm for these new ideas.

Parental Characteristics, Ecological Factors, and the Academic Achievement of African American Males

Science.gov (United States)

Hines, Erik M.; Holcomb-McCoy, Cheryl

2013-01-01

Parental characteristics, ecological factors, and the academic achievement of African American male high school students were examined. One hundred fifty-three 11th and 12th grade African American males completed the Parenting Style Index (Steinberg, Lamborn, Darling, Mounts, & Dornbusch, 1994) and a demographic questionnaire. Results…

Professional Accountability for Improving Life, College, and Career Readiness

Science.gov (United States)

Snyder, Jon; Bristol, Travis J.

2015-01-01

This article builds on Darling-Hammond, Wilhoit, and Pittenger's (2014) new paradigm on "Accountability for College and Career Readiness" by focusing on one of its three pillars--professional accountability. The article begins by offering a conceptual framework for professional accountability for improvement. Next, it highlights slices…

Asymptotics for ratios with applications to reinsurance

NARCIS (Netherlands)

Ladoucette, S.A.; Teugels, J.L.

2007-01-01

This paper provides an overview of results pertaining to moment convergence for certain ratios of random variables involving sums, order statistics and extreme terms in the sense of modulus. Most of the literature on this matter originates from Darling (1952) who gave a criterion for the convergence

An Extreme-Value Analysis of the LIL for Brownian Motion

OpenAIRE

Khoshnevisan, Davar; Levin, David; Shi, Zhan

2005-01-01

We use excursion theory and the ergodic theorem to present an extreme-value analysis of the classical law of the iterated logarithm (LIL) for Brownian motion. A simplified version of our method also proves, in a paragraph, the classical theorem of Darling and Erdős (1956).

We still love SUSY

International Nuclear Information System (INIS)

Anon.

1992-01-01

Supersymmetry, affectionately known as SUSY, is still the darling of theoretical particle physics. Invented some 20 years ago, the charismatic idea really took off at the beginning of the 1980s. At the time, a workshop at CERN reflected the youthful enthusiasm for these new ideas

Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment.

Science.gov (United States)

Wheat, Joseph; Myint, Thein; Guo, Ying; Kemmer, Phebe; Hage, Chadi; Terry, Colin; Azar, Marwan M; Riddell, James; Ender, Peter; Chen, Sharon; Shehab, Kareem; Cleveland, Kerry; Esguerra, Eden; Johnson, James; Wright, Patty; Douglas, Vanja; Vergidis, Pascalis; Ooi, Winnie; Baddley, John; Bamberger, David; Khairy, Raed; Vikram, Holenarasipur R; Jenny-Avital, Elizabeth; Sivasubramanian, Geetha; Bowlware, Karen; Pahud, Barbara; Sarria, Juan; Tsai, Townson; Assi, Maha; Mocherla, Satish; Prakash, Vidhya; Allen, David; Passaretti, Catherine; Huprikar, Shirish; Anderson, Albert

2018-03-01

Central nervous system (CNS) involvement occurs in 5 to 10% of individuals with disseminated histoplasmosis. Most experience has been derived from small single center case series, or case report literature reviews. Therefore, a larger study of central nervous system (CNS) histoplasmosis is needed in order to guide the approach to diagnosis, and treatment.A convenience sample of 77 patients with histoplasmosis infection of the CNS was evaluated. Data was collected that focused on recognition of infection, diagnostic techniques, and outcomes of treatment.Twenty nine percent of patients were not immunosuppressed. Histoplasma antigen, or anti-Histoplasma antibodies were detected in the cerebrospinal fluid (CSF) in 75% of patients. One year survival was 75% among patients treated initially with amphotericin B, and was highest with liposomal, or deoxycholate formulations. Mortality was higher in immunocompromised patients, and patients 54 years of age, or older. Six percent of patients relapsed, all of whom had the acquired immunodeficiency syndrome (AIDS), and were poorly adherent with treatment.While CNS histoplasmosis occurred most often in immunocompromised individuals, a significant proportion of patients were previously, healthy. The diagnosis can be established by antigen, and antibody testing of the CSF, and serum, and antigen testing of the urine in most patients. Treatment with liposomal amphotericin B (AMB-L) for at least 1 month; followed by itraconazole for at least 1 year, results in survival among the majority of individuals. Patients should be followed for relapse for at least 1 year, after stopping therapy.

Hip-Hop Literature: The Politics, Poetics, and Power of Hip-Hop in the English Classroom

Science.gov (United States)

Kelly, Lauren Leigh

2013-01-01

There is an educational disconnect between students' individual backgrounds and the instruction that they traditionally receive in school (Darling-Hammond 3). This division is even more severe for black, Latino/Latina, and economically underprivileged students, who often lack the support, experience, or resources to fully engage in…

Beyond Authoritarianism: A Cultural Perspective on Asian American Parenting Practices.

Science.gov (United States)

Chao, Ruth K.

A study was conducted to determine Asian American conceptualizations of parenting, focusing on socialization goals, parenting style, and parenting practices related to schooling, aspects of parental influences discussed by D. Darling and L. Steinberg (1993). It was suggested that the standard conceptualizations of parenting style, those of D.…

Romanticizing Culture: The Role of Teachers' Cultural Intelligence in Working with Diversity

Science.gov (United States)

Molina, Sarina Chugani

2013-01-01

As the world is becoming increasingly flat (Ang, Van Dyne, Koh, Templer, & Chandrasekar, 2007; Darling-Hammond, 2010; Friedman, 2005), the classroom has become a mirror that often reflects this phenomenon at a microcosmic level. As such, teacher preparation programs are continuing to emphasize the importance of understanding and valuing…

Character in Action: A Case of Authentic Educational Leadership That Advanced Equity and Excellence

Science.gov (United States)

Beard, Karen Stansberry

2013-01-01

The third pillar of No Child Left Behind emphasizes determining which educational programs and practices have been proven effective through rigorous scientific research. This study addressed Davis, Darling-Hammond, LaPointe, and Meyerson's (2005) call for a "need for additional research to determine the impact and relative importance of…

Data Drive These Coaches: Literacy Project Merges School Goals with Teachers' Learning Needs

Science.gov (United States)

Ittner, Anne; Helman, Lori; Burns, Matthew; McComas, Jennifer

2015-01-01

Research highlights the importance of individualized approaches and coaching to ongoing professional learning (Darling-Hammond, Wei, Andree, Richardson, & Orphanos, 2009). The purpose of this article is to describe an initiative that set out to help all students become proficient readers by 3rd grade. It demonstrates how coaching can support…

Book of abstracts. Thirty ninth annual scientific meeting

International Nuclear Information System (INIS)

2009-04-01

The 39 th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine was held in Sydney, Australia. The Meeting was held from Thursday, 23 April to Monday, 27 April at the Sydney Convention and Exhibition Centre in Darling Harbour and the theme was Multimodality - Here and Now.

An Expert Instructor's Use of Social Congruence, Cognitive Congruence, and Expertise in an Online Case-Based Instructional Design Course

Science.gov (United States)

Watson, Sunnie Lee; Koehler, Adrie A.; Ertmer, Peggy; Kim, WooRi; Rico, Rudy

2018-01-01

Promoting and sustaining effective discussion--that which contributes to learning--is a skill that eludes many instructors (Darling-Hammond, 2008; Ge, Yamashiro, & Lee, 2000). This study explored the role and strategies of an expert instructor in an online advanced instructional design (ID) course that utilized a case-based learning (CBL)…

75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

Science.gov (United States)

2010-04-27

.... Phillips, Joseph A. Ragan, Mark C. Reineke, David J. Schie, David M. Sims, Roland D. Spaniol, Kevin Stein... conditions: James H. Bailey, Johnny J. Campbell, Malcolm J. Celestine, Dale G. Darling, Keith E. Fimon.... Georgeff, Joseph Revis, Jr., Lawrence C. Smoak, III, David C. Watson, Paula L. Wharton. One applicant...

Dropout Factories: The Profitability of "At-Risk" Students

Science.gov (United States)

Eastman, Nicholas J.

2016-01-01

Every public school teacher today is charged, above all else, with a utilitarian form of workforce preparation: college and career readiness. The distinction between college and career is superficial. The overarching goal of both is career readiness, and STEM careers are the darlings of the "readiness" discourse. Within the STEM reform…

Teacher Retention and Satisfaction with a Servant Leader as Principal

Science.gov (United States)

Shaw, Jimmy; Newton, Jodi

2014-01-01

If the most precious product developed in education is the student, then our most prized commodity should be the classroom teacher. According to numerous studies (Allen, Pianta, Gregory, Mikami, & Lun, 2011; Clotfelter, Ladd, & Vigdor, 2010; Darling-Hammond, 2000), the greatest influence on a student's achievement is the classroom…

Histoplasma-associated inflammatory pseudotumour of the kidney mimicking renal carcinoma

NARCIS (Netherlands)

M.A. den Bakker (Michael); N.N.T. Goemaere (Natascha); J.A. Severin (Juliëtte); J.L. Nouwen (Jan); P.C.M.S. Verhagen (Paul)

2009-01-01

textabstractA 56-year-old female, originally from Suriname, with an otherwise unremarkable previous medical history was found to have a renal mass highly suspicious for renal cancer for which a nephrectomy was performed. Within the kidney, a tumourous mass was found which, on histological

Afghanistan: Narcotics and U.S. Policy

Science.gov (United States)

2008-01-24

markets, and to restore wheat and other cereal crop production levels. Work began on phase one projects in early 2005 and continued through 2006...Barnett, “UK in Secret Biological War on Drugs,” Observer (London), September 17, 2000; Juanita Darling, “ Fungi May Be the Newest Recruits in War on Drugs

Wonder girls: Undercurrents of resistance in the representation of teenage girls in 1980s American cinema

NARCIS (Netherlands)

Wilkinson, M.C.

2013-01-01

This thesis explores the representation of teenage girls in 1980s American teen films such as Little Darlings (1980), Smooth Talk (1985), Just One of the Guys (1985), Pretty in Pink (1986) and Mermaids (1990). It uses film analysis and feminist film theory to subject a range of case studies to three

Plaadid : Pop & rock. Ameerika. Klassika

Index Scriptorium Estoniae

2002-01-01

Uutest heliplaatidest. Kid Loco "Kill Your Darlings", Creed "Weathered", Cranberries "Wake Up and Smell the Coffee", "America - A Tribute To Heroes", "The Concert For New York City", "God Bless America", Michael Nyman "The Very Best of Film Music 1980-2001". Eesti plaadid : Dave Benton "From Monday to Sunday", 2 Quick Start "Ühena miljoneist"

Distorting the Past

Science.gov (United States)

Klehr, Harvey

2004-01-01

Many historians on the left are unwilling to renounce communism and the agents in this country who ran its insidious errands. Despite damning evidence from Soviet archives, Julius and Ethel Rosenberg, Alger Hiss, and other traitors remain the darlings of many leaders of the profession. Harvey Klehr documents how, in journals and recent textbooks,…

Digital Adults: Beyond the Myth of the Digital Native Generation Gap

Science.gov (United States)

Tufts, Debra Roben

2010-01-01

The digital native has been the darling of market research and a major focus of education consternation throughout the first decade of the 2000s. These are the children and young adults the literature describes as those born after 1980 and who exhibit high technical savvy, particularly as it pertains to information and communication technology…

Changing the Game: What Happens when Video Games Enter the Classroom?

Science.gov (United States)

Squire, Kurt

2005-01-01

Over the past few years, games have gone from social pariahs to the darlings of the media, technology, and now educational industries. E-learning educators in particular stand to learn a lot about building next-generation learning environments from games. While online courses are usually little more than "online course notes," games offer entire…

Sõrmuste isand Karl Fritsch / Merike Alber

Index Scriptorium Estoniae

Alber, Merike

2008-01-01

Saksa ehtekunstniku Karl Fritschi (sünd. 1963) näitus "Metrosideros robusta. Ehted" Eesti Tarbekunsti- ja Disainimuuseumis kuni 29. VI. Karl Fritsch pälvis 2006. a. Francoise van den Boschi (hollandi ehtekunstnik, 1944-1977) auhinna, 1995. ja 2007. a. Herbert Hoffmanni preemia. Darling Publications kirjastas Karl Fritschist raamatud "Metrosideros Robusta" ja "Baby Brick"

Things to Remember During the Teacher Hiring Season. Newsletter

Science.gov (United States)

Center for Comprehensive School Reform and Improvement, 2005

2005-01-01

Of all the factors that schools control, teacher quality is the one that most affects student achievement (Darling-Hammond, 2000). In fact, researcher Eric Hanushek (2002) found the difference in annual student achievement growth between a student taught by an effective teacher and one taught by an ineffective teacher can be as much as one…

Guidelines for inclusion: Ensuring Indigenous peoples' involvement in water planning processes across South Eastern Australia

Science.gov (United States)

Saenz Quitian, Alejandra; Rodríguez, Gloria Amparo

2016-11-01

Indigenous peoples within the Murray-Darling Basin have traditionally struggled for the recognition of their cultural, social, environmental, spiritual, commercial and economic connection to the waters that they have traditionally used, as well as their right to engage in all stages of water planning processes. Despite Australian national and federal frameworks providing for the inclusion of Indigenous Australians' objectives in planning frameworks, water plans have rarely addressed these objectives in water, or the strategies to achieve them. Indeed, insufficient resources, a lack of institutional capacity in both Indigenous communities and agencies and an inadequate understanding of Indigenous people's objectives in water management have limited the extent to which Indigenous objectives are addressed in water plans within the Murray-Darling Basin. In this context, the adoption of specific guidelines to meet Indigenous requirements in relation to basin water resources is crucial to support Indigenous engagement in water planning processes. Using insights from participatory planning methods and human rights frameworks, this article outlines a set of alternative and collaborative guidelines to improve Indigenous involvement in water planning and to promote sustainable and just water allocations.

La promoción de la salud en el contexto del desarrollo social

Directory of Open Access Journals (Sweden)

Enrique Guada

2002-01-01

Full Text Available En el marco del desarrollo social, la promoción de la salud pretende el logro del bienestar y la calidad de vida individual, familiar y comunitaria, reconciliando los intereses particulares con lo institucional y colectivo, incorporando la participación ciudadana en la gestión de salud. Ese ser humano íntegro, forma parte de un grupo familiar y es miembro de una comunidad, es el ser humano cotidiano dentro de su realidad social, en una búsqueda permanente de protagonizar su propio proceso de vida, desde la perspectiva de la salud integral y de un proyecto de salud comunitario. La noción moderna de salud está asociada a la prevención, más aún en los países en vías de desarrollo con enormes dificultades económicas para darle sustentabilidad a los procesos de desarrollo humano. La Promoción de la Salud toma cada vez mayor importancia para darle viabilidad a los procesos que buscan la superación de la pobreza en sus múltiples expresiones

Cine y psicología: las emociones en el cine de terror y la comedia en personajes trastornados

OpenAIRE

Cabrera Muñoz, Beatriz

2013-01-01

Se analiza la visión que se ha dado en el cine sobre los trastornos de la personalidad. Cómo el comunicador construye a esos personajes para darle la mayor credibilidad y realidad posible. Se repasan las diferentes estrategias empleadas en el lenguaje cinematográfico en los géneros de terror y comedia

Artes y posconflicto

Directory of Open Access Journals (Sweden)

PENSAMIENTO, PALABRA Y OBRA

2014-12-01

No bastará que las artes estén presentes en el nuevo escenario social. Tenemos que formular política y tenemos que formar  a  quienes  se  encargarán  de darle sentido a las artes en la escuela, en los espacios comunitarios, en los medios masivos, en fin, en la vida.

SRM, motor para el desarrollo de la cadena de valor Supplier Relationship Management – SRM gestión de las relaciones con los proveedores

Directory of Open Access Journals (Sweden)

Luis Leonardo Mendoza S.

2010-01-01

Ejemplo de ello es el SRM, Supplier Relationship Management, en donde por medio de la constitución de acuerdos basados en intereses comunes, se establecen relaciones estrechas, funcionales y eficientes entre las partes, permitiendo por esta vía la garantía del suministro, y de esta forma, darle un importante impulso para el desarrollo de la cadena de valor.

78 FR 2955 - Marine Mammals; File Nos. 14451, 14353, and 13846

Science.gov (United States)

2013-01-15

..., Oakland, CA 94611; and Jim Darling, Ph.D., Whale Trust, P.O. Box 384, Tofino, BC V0R2Z0, Canada, have... area throughout the Hawaiian Islands, including the Northwestern Hawaiian Islands (NWHI) chain. Permit...., Whale Trust, P.O. Box 384, Tofino, BC V0R2Z0, Canada, to study humpback whales in Hawaii (primarily off...

Quantifying an Integral Ecology Framework: A Case Study of the Riverina, Australia

Science.gov (United States)

Wheeler, Sarah A.; Haensch, Juliane; Edwards, Jane; Schirmer, Jackie; Zuo, Alec

2018-02-01

Communities in Australia's Murray-Darling Basin face the challenge of trying to achieve social, economic, and environmental sustainability; but experience entrenched conflict about the best way to achieve a sustainable future, especially for small rural communities. Integral ecology is a philosophical concept that seeks to address community, economic, social, and environmental sustainability simultaneously. Its inclusive processes are designed to reduce stakeholder conflict. However, to date the application of the integral ecology concept has been largely qualitative in nature. This study developed a quantitative integral ecology framework, and applied this framework to a case study of the Riverina, in the Murray-Darling Basin. Seventy-seven community-focused initiatives were assessed, ranked, and quantified. The majority of the community-focused ranked initiatives did not exhibit all aspects of integral ecology. Initiatives typically prioritized either (1) economic and community development or (2) environmental health; rarely both together. The integral ecology framework developed here enables recommendations on future community initiatives and may provide a pathway for community leaders and other policy-makers to more readily apply integral ecology objectives. Further research refining the framework's operationalization, application and implementation to a wider-scale may enhance communities' capacity to develop and grow sustainably.

Shallow groundwater resources and future climate change impacts: a comparison of the Ovens and Namoi catchments, Eastern Australia

Energy Technology Data Exchange (ETDEWEB)

Smith, T.J., E-mail: tjsmith@skm.com.au [Sinclair Knight Merz, Malvern, Victoria (Australia); Mudd, G.M., E-mail: gavin.mudd@monash.edu [Monash University, Clayton, Victoria (Australia). Dept. of Civil Engineering

2010-07-01

The Murray-Darling Basin (MDB) river system is a critical province and water resource for Eastern Australia. Over the past decade the MDB has been subject to a protracted and severe drought, as well undergoing major institutional, social and economic reforms. A lesser understood area of MDB water resource issues is the status of groundwater, especially with respect to trends in groundwater resources, groundwater-surface water issues and the longer term susceptibility of groundwater to climate variability and climate change. Following the cap on MDB surface water allocations in 1994, a major expansion of groundwater use was observed across many parts of the MDB, which has probably been further exacerbated by the current drought leading to lower groundwater recharge. This paper presents an overview of the current status of Murray-Darling Basin groundwater resource use and management, contrasts two case study sites in the Ovens and Namoi catchments of Victoria and New South Wales respectively, assesses the potential risks that climate variability and climate change present, and finally considers some long term solutions to ensure that the MDB continues on its transition to a more sustainable future.

Best Statistical Distribution of flood variables for Johor River in Malaysia

Science.gov (United States)

Salarpour Goodarzi, M.; Yusop, Z.; Yusof, F.

2012-12-01

A complex flood event is always characterized by a few characteristics such as flood peak, flood volume, and flood duration, which might be mutually correlated. This study explored the statistical distribution of peakflow, flood duration and flood volume at Rantau Panjang gauging station on the Johor River in Malaysia. Hourly data were recorded for 45 years. The data were analysed based on water year (July - June). Five distributions namely, Log Normal, Generalize Pareto, Log Pearson, Normal and Generalize Extreme Value (GEV) were used to model the distribution of all the three variables. Anderson-Darling and Kolmogorov-Smirnov goodness-of-fit tests were used to evaluate the best fit. Goodness-of-fit tests at 5% level of significance indicate that all the models can be used to model the distribution of peakflow, flood duration and flood volume. However, Generalize Pareto distribution is found to be the most suitable model when tested with the Anderson-Darling test and the, Kolmogorov-Smirnov suggested that GEV is the best for peakflow. The result of this research can be used to improve flood frequency analysis. Comparison between Generalized Extreme Value, Generalized Pareto and Log Pearson distributions in the Cumulative Distribution Function of peakflow

The Silver Darlings: An Emblem of the Scottish Sea and History

OpenAIRE

Berton-Charrière, Danièle

2017-01-01

From the Middle Ages onwards, herring—one of the most used marine resources—has provided Scotland with a precious, cheap, plentiful and nutritious source of food. Fishing was first a subsistence activity, and it then developed into an industry. Once in unbelievable abundance—the Old German word ‘herring’ means ‘multitude’—herring attracted thousands of boats from all over Europe to the Scottish waters, and at the peak of the herring boom, Britain exported a quarter of a million tonnes a year....

A new species of Smicromorpha (Hymenoptera, Chalcididae from Vietnam, with notes on the host association of the genus

Directory of Open Access Journals (Sweden)

Chris Darling

2009-09-01

Full Text Available Smicromorpha masneri Darling, sp. n. is described from Bach Ma National Park, Thua Thien-Hue Province, Vietnam. This is the first confirmed record for the genus on mainland southeast Asia. It is generally accepted that species of Smicromorpha are parasitoids of green tree or weaver ants, Oecophylla smaragdina (Fabricius but this is first rearing record of these parasitoids from the nests of weaver ants.

Ehtekunsti kõrgmäestik Münchenis / Kadri Mälk, Piret Hirv, Tanel Veenre

Index Scriptorium Estoniae

Mälk, Kadri, 1958-

2009-01-01

Ehtekunsti suurüritusest "Schmuckszene" ("Ehtepaik"). Arnoldsche Art Publishers esitles viit aasta paremaks ehtekunstiraamatuks tituleeritut, nende seas Eestis trükikojas Pakett trükitud raamatut "Just must" (kujundaja Aadam Kaarma, fotod: Tanel Veenre). Darling Publications'i poolt esitletud raamatust "The Compendium Finale of Contemporary Jewellery Makes", kus tutvustatakse kümmet eesti ehtekunstnikku, tekstide autorid on Kadri Mälk, Harry Liivrand ja Tamara Luuk

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing

Science.gov (United States)

O’Donovan, Brian D.; Gelfand, Jeffrey M.; Sample, Hannah A.; Chow, Felicia C.; Betjemann, John P.; Shah, Maulik P.; Richie, Megan B.; Gorman, Mark P.; Hajj-Ali, Rula A.; Calabrese, Leonard H.; Zorn, Kelsey C.; Chow, Eric D.; Greenlee, John E.; Blum, Jonathan H.; Green, Gary; Khan, Lillian M.; Banerji, Debarko; Langelier, Charles; Bryson-Cahn, Chloe; Harrington, Whitney; Lingappa, Jairam R.; Shanbhag, Niraj M.; Green, Ari J.; Brew, Bruce J.; Soldatos, Ariane; Strnad, Luke; Doernberg, Sarah B.; Jay, Cheryl A.; Douglas, Vanja; Josephson, S. Andrew; DeRisi, Joseph L.

2018-01-01

, Aspergillus oryzae, Histoplasma capsulatum, and Candida dubliniensis) were identified among the 7 participants by using mNGS. Evaluating mNGS data with a weighted z score–based scoring algorithm reduced the reported microbial taxa by a mean of 87% (range, 41%-99%) when taxa with a combined score of 0 or less were removed, effectively separating bona fide pathogen sequences from spurious environmental sequences so that, in each case, the causative pathogen was found within the top 2 scoring microbes identified using the algorithm. Conclusions and Relevance Diverse microbial pathogens were identified by mNGS in the CSF of patients with diagnostically challenging subacute or chronic meningitis, including a case of subarachnoid neurocysticercosis that defied diagnosis for 1 year, the first reported case of CNS vasculitis caused by Aspergillus oryzae, and the fourth reported case of C dubliniensis meningitis. Prioritizing metagenomic data with a scoring algorithm greatly clarified data interpretation and highlighted the problem of attributing biological significance to organisms present in control samples used for metagenomic sequencing studies. PMID:29710329

Los centros de gravedad de la Web

Directory of Open Access Journals (Sweden)

Sandra González-Bailón

2009-12-01

Full Text Available El acceso a información en la Web no es independiente de la estructura de red que forman los enlaces entre páginas y dominios. Los buscadores reconstruyen mapas de esas conexiones para identificar los recursos más centrales y darles prioridad en sus algoritmos. Sin embargo, la estructura de la Web no responde sólo a la calidad de los contenidos.

Mobilization of the south against food crisis

Directory of Open Access Journals (Sweden)

Laurent Delcourt

2009-06-01

Full Text Available “Creemos que a esta crisis alimentaria hay que darle un nombre más exacto. Todavía no damos con ese nombre. Pero no es una crisis de alimentos,es una crisis de valores en las empresas transnacionales, en los gobiernos y en la cooperación internacional”, Sinforiano Cáceres, presidente de la Federación nacional de cooperativas, Nicaragua (Envío, 2008.

Proposal of the genus Sphingomonas sensu stricto and three new genera, Sphingobium, Novosphingobium and Sphingopyxis, on the basis of phylogenetic and chemotaxonomic analyses.

Science.gov (United States)

Takeuchi, M; Hamana, K; Hiraishi, A

2001-07-01

Phylogenetic analyses of 16S rRNA gene sequences by distance matrix and parsimony methods indicated that the currently known species of the genus Sphingomonas can be divided into four clusters. Some chemotaxonomic and phenotypic differences were noted among these clusters. Three new genera, Sphingobium, Novosphingobium and Sphingopyxis, are proposed in addition to the genus Sphingomonas sensu stricto. The genus Sphingobium is proposed to accommodate Sphingomonas chlorophenolica, Sphingomonas herbicidovorans and Sphingomonas yanoikuyae. The genus Novosphingobium is proposed for Sphingomonas aromaticivorans, Sphingomonas capsulata, Sphingomonas rosa, Sphingomonas stygia, Sphingomonas subarctica and Sphingomonas subterranea. Sphingomonas macrogoltabidus and Sphingomonas terrae are reclassified in the genus Sphingopyxis. The type species of Sphingobium, Novosphingobium and Sphingopyxis are Sphingobium yanoikuyae, Novosphingobium capsulatum and Sphingopyxis macrogoltabida, respectively.

Support of the Laboratory in the Diagnosis of Fungal Ocular Infections

Science.gov (United States)

Vanzzini Zago, Virginia; Alcantara Castro, Marino; Naranjo Tackman, Ramon

2012-01-01

This is a retrospective, and descriptive study about the support that the laboratory of microbiology aids can provide in the diagnosis of ocular infections in patients whom were attended a tertiary-care hospital in México City in a 10-year-time period. We describe the microbiological diagnosis in palpebral mycose; in keratitis caused by Fusarium, Aspergillus, Candida, and melanized fungi; endophthalmitis; one Histoplasma scleritis and one mucormycosis. Nowadays, ocular fungal infections are more often diagnosed, because there is more clinical suspicion and there are easy laboratory confirmations. Correct diagnosis is important because an early medical treatment gives a better prognosis for visual acuity. In some cases, fungal infections are misdiagnosed and the antifungal treatment is delayed. PMID:22518339

Review of world genera of Ceinae, with the description of two new Palaearctic species of Spalangiopelta Masi (Hymenoptera, Chalcidoidea, Pteromalidae

Directory of Open Access Journals (Sweden)

Mircea-Dan Mitroiu

2016-12-01

Full Text Available The paper provides the first illustrated key to all described genera of Ceinae, i.e., Bohpa Darling, 1991, Cea Walker, 1837, and Spalangiopelta Masi, 1922. Based on the study of the original material, the genus Diparisca Hedqvist, 1964 stat. nov. is removed from the synonymy with Spalangiopelta and its higher classification is discussed. Spalangiopelta rameli sp. nov. and S. viridis sp. nov. are described from Greece and the Canary Islands, respectively.

Los derivados financieros desde una perspectiva jurídica

OpenAIRE

Cuartas Gómez, Lucas; Sierra Vásquez, Paula

2008-01-01

El importante aumento en el uso de los contratos de derivados en Colombia1 y el mundo, además de la dificultad que puede traer su comprensión, nos ha llevado a escribir el presente trabajo, con el fin de darle a el lector una perspectiva general sobre el funcionamiento de estos instrumentos financieros, su regulación en Colombia y la forma como éstos se han venido contratando a nivel internacional.

Toward a Leaner, More Agile Force: The Army in a Time of Fiscal Austerity

Science.gov (United States)

2016-10-27

National Guard 3650 Saylors Pond Road Joint Base McGuire-Dix-Lakehurst, New Jersey 08640 609-562-0948 brian.c.darling.mil@mail.mil Dear...Qaeda and other terrorist groups, the pivot to the Asia-Pacific has been delayed. Meanwhile, it is still necessary to reduce the size of the Army...involved, creating an equal partnership between American Soldiers and those of our allies. Budget woes and the pivot to the Asia- Pacific are making

Defense Labs: The Innovation Engine for Sustaining Our Quality Edge

Science.gov (United States)

2015-10-01

to magnetics. • Dr. Rasha Hammamieh, U.S. Army Center for Environ- mental Health , for her work in the Post-Traumatic Stress Disorder (PTSD) Systems...U.S. Army Aeromedical Research Laboratory (USAARL) • U.S. Army Center for Environmental Health Research (USACEHR) • U.S. Army Institute of...themselves in those same roles, and it pushes them to pursue STEM fields,” says Faith Darling, the STEM Coordinator at the Bullis School in Potomac

A nonpedagogical teacher education?

DEFF Research Database (Denmark)

Kvols, Anja Madsen; Madsen, Peter Hougaard; Beck, Mette Holdsendorf

regarding changes in education – which seem to come from evaluations more than from educational and pedagogical theories (Gruschka, 2011). Moreover, the teacher education has increased its focus on both research-based academic training and professional training at the same time. Our study is double – 1...... characterizes teacher professionalism? (Subject studies? Pedagogical studies? Professional training? Academic studies? Bildung studies? Etc.) - What characterizes ‘pedagogy of teacher education’ (Darling-Hammond, 2006; Loughran, 2008; Zeichner, 2005)?...

Lake Darling Flood Control Project, Souris River, North Dakota. General Project Design.

Science.gov (United States)

1983-06-01

difference between the air temperature measured at 10 feet and snow surface temperature. Td ’ - is the difference between dewpoint temperature measured at 10...to atmospheric conditions in the river reach between the outlet of the dam and the gage. f. Total dissolved solids ( TDS ) are generally considered to be...C c o o c a m m o i p - g - *tm-ett 41JI IhcaU ICI (U 4 ) flU)WwooQ- flJ ~rVlrnj M W Nfr- r- 0 r- M WMM - I# )-z .Lr n LZ n Lrr r 4r 111

Who is Everyone's Darling in Cyberspace? The Characteristics of Popular Online Daters

Directory of Open Access Journals (Sweden)

Chih-Chien Wang

2010-06-01

Full Text Available Online dating current is a popular activity in cyberspace. More and more people make new friends and find their partners through online dating web sites. There is an interesting observation that some people are more popular than others in online dating web sites. The current study focuses on the personal profile characteristics that make one a popular dater. By two field surveys, this study discusses the relationship between online daters' personal profiles and their popularity. The first survey investigated 800 online daters' profiles from dating web sites. The statistical analysis results indicated thatphysical body types and looks, education level, occupation, personality, and interests were characteristics that influenced the popularity of online daters, while significant gender differences were found in the characteristics that related to popularity of online daters. The second survey searched 960 online daters with profiles of popular and unpopular characteristics. By observing the popularity of these online daters, it was found that those with "popular" characteristics also were the popular daters and those with "unpopular" characteristics were the unpopular daters. This may serve as evidence that the found personal profile characteristics were indeed factors influencing the popularity of the online daters.

Adaptive salinity management in the Murray-Darling Basin: a transaction cost study

Science.gov (United States)

Loch, A. J.

2017-12-01

Transaction costs hinder or promote effective management of common good resource intertemporal externalities. Appropriate policy choices may reduce externalities and improve social welfare, and transaction cost analysis can help to evaluate policy choices. However, without measurement of relevant transaction costs such policy evaluation remains challenging. This article uses a time series dataset of salinity management program to test theory aimed at transaction cost-based policy evaluation and adaptive resource management over a period of 30 years worth of data. We identify peaks and troughs in transaction costs over time, lag-effects in program expenditure, and calculate the decay in transaction cost impacts. We conclude that Australian salinity management programs are achieving flexible institutional outcomes and effective policy arrangements with long-term benefits. Proposed changes to the program moving forward add weight to our assertions of adaptive strategies, and illustrate the value of the novel data-driven tracnsaction cost analysis approach for other jurisdictions.

Bridging the Gap between Scientific and Indigenous knowledge to Better Understand Social Impacts of Changing Rainfall Regimes

Science.gov (United States)

Lynch, A. H.; Joachim, L.; Zhu, X.; Hammer, C.; Harris, M.; Griggs, D.

2011-12-01

The Murray-Darling Basin incorporates Australia's three longest rivers and is important for an agricultural industry worth more than $9 billion per annum, a rich biodiversity of habitat and species, and the very life of its traditional owners. The complex and sometimes enigmatic relationships between modes of variability and Australian regional rainfall distribution means that reliable projections of future water availability remain highly uncertain. Persistent drought, with associated heat stress and high fire danger, and episodic flooding rains present further challenges. Indeed, recent extremes likely herald a tipping point for the communities and ecosystems that rely on the river system. The Barmah-Millewa region in the Murray-Darling Basin is the heart of Yorta Yorta Traditional Tribal Lands. The Yorta Yorta continue to assert their inherent rights to country and have shown through oral, documentary and material evidence, that their social, spiritual, economic and cultural links with country have never been broken. Current water policy and practice, highly contested community consultation processes, cross-border governance issues and a changing social landscape create in this region a microcosm for understanding the complex demands of economic, environmental and cultural security along the Murray-Darling Basin as the climate changes. New approaches to bridging the gap between scientific and Indigenous epistemologies have emerged in recent years, including for example ecosystem-based adaptation (Vignola et al. 2009) and the analysis of cultural water flows (Weir 2010). The potential for innovation using these approaches has informed a study that investigates how the deep knowledge of country of the Yorta Yorta people can be combined with state of the art climate science to develop a better understanding of the competing demands on water resources in the Barmah-Millewa region now and in the future. An important dimension of this collaborative work with the Yorta

Realidad virtual como buena práctica para trabajo en equipo con estudiantes de ingeniería

OpenAIRE

Gasca-Hurtado G.P.; Peña A.; Gómez-Álvarez M.C.; Plascencia-Osuna O.A.; Calvo-Manzano J.A.

2015-01-01

La realidad virtual es una alternativa de motivación de los estudiantes al darles la posibilidad de realizar acciones como volar u observar el entorno desde diferentes perspectivas de manera controlada. La interacción multiusuario en realidad virtual da lugar a los entornos virtuales colaborativos que favorecen el desarrollo de habilidades sociales como el trabajo en equipo, en particular en equipos con integrantes con ubicaciones geográficas diferentes. En estos contextos se encuentran diver...

Usted puede ser Empresario!

Directory of Open Access Journals (Sweden)

Pedro A. López Guzmán

1988-04-01

Full Text Available RESUMEN Con este artículo se pretende  que usted  señor lectos ea  un empresario consciente y lo más competente posible. A medida que usted mismo pueda plantearse un problema e ir  resumiendo y analizando los datos que ha obtenido, verá de qué manera esa práctica contribuirá a darle la claridad mental necesaria para encarar con éxito su tarea de Empresario.

Sistema de actividades para lograr que la Secundaria Básica se convierta en Palacio de Pioneros

Directory of Open Access Journals (Sweden)

Margot Hernández Leyva

2017-11-01

Full Text Available Se propone un sistema de acciones para darle salida al funcionamiento de la escuela como palacio de pioneros, teniendo en cuenta la integración de componentes como: la educación patriótica, la orientación profesional, la educación física y el deporte, la educación artística y estética, La salud escolar y el trabajo preventivo, y la educación laboral.

LA ORALIDAD COMO PARTE DE LA INVESTIGACIÓN HISTÓRICA: DE LAS FUENTES ORALES A LA LLAMADA HISTORIA ORAL

Directory of Open Access Journals (Sweden)

José Ignacio Reyes González

2010-03-01

Full Text Available El artículo profundiza en uno de los temas más polémicos de la investigación histórica, lo relacionado con el reconocimiento del valor de las fuentes orales para reconstruir la historia. Se exponen los argumentos que fundamentan la necesidad de darle el espacio que merece la historia oral, así como la connotación que esto puede tener para la enseñanza de la disciplina.

Employment-based health benefits and public-sector coverage: opportunity for leadership.

Science.gov (United States)

Darling, Helen

2006-01-01

In this commentary, Helen Darling, speaking from the large-employer perspective, responds to James Robinson's paper on the mature health insurance industry, which faces declining opportunities with employer-based health benefits and growing but less appealing public-sector opportunities for management and other services. The similar needs of public and private employers and payers provide an opportunity for leadership, accelerating innovation and using value-added services to improve safety, quality, and efficiency of health care for all.

Supracardiac total anomalous pulmonary venous connection with a descending vertical vein.

Science.gov (United States)

Shah, Sejal; Singh, Mukesh; John, Colin; Maheshwari, Sunita

2009-10-01

The commonly used Darling classification for total anomalous pulmonary venous connection (TAPVC) consists of supracardiac, cardiac, infracardiac, and mixed types (Craig et al., Lab Invest 6:44-64, 1967). In supracardiac TAPVC, the common pulmonary vein drains superiorly into the left innominate vein, the superior vena cava, or the azygos vein by way of an ascending vertical vein. We describe a case of supracardiac TAPVC draining into the azygos vein atypically by way of a descending vertical vein.

Espaço Literário Queer em “Triunfo dos Pelos”, DE Aretusa Von, e “Mi Buenos Aires Querido”, de Cíntia Moscovich

Directory of Open Access Journals (Sweden)

Adelaide Calhman de Miranda

2012-04-01

Full Text Available This article analyses the connection between urban space and sexual diversity in two contemporary Brazilian short stories: “The triumph of hair”, by Aretusa Von, and “My darling Buenos Aires”, by Cíntia Moscovich. Both texts question the space/gender relation, as they accuse and subvert the gendered nature of geographic and discursive places. Besides this, they outline a type of queer space, by questioning compulsory heterosexuality and by deconstructing the binaries that hierarchize contemporary society.   

Bestiarios medievales e imaginario social

OpenAIRE

Valentini, Carlos; Ristorto, Marcela

2015-01-01

Los historiadores medievalistas se concentran, en la actualidad, en descubrir y penetrar el sistema de valores, creencias y sentimientos de hombres y mujeres de aquella época, cómo se representaban el mundo y el espíritu de una sociedad para la cual lo invisible merecía tanto interés como lo visible. Los Bestiarios fueron considerados en su época libros de historia natural y sus autores pretendieron darles características científicas...

Instabilities of Damage and Surface Degradation Mechanisms in Brittle Material Structural Systems

Science.gov (United States)

1992-03-15

metals and the spacing of travelling Portevin- Le Chatelier bands in viscoplastic metals [Zbib and Aifantis 1988]. The origin of higher order strain...DTIC AFOSR*TR* 02I MAY1 9 1992 fl THE UNIVERSrYOF C DARlZONA AD-A250 785 TUCSON AjuzoN lE liti IIl lFinal Report AFOSR Grant No. 89-0460...for a conservative system can be described by the principle of minimum potential energy. The principle of minimum potential energy dictates that a

Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study

OpenAIRE

Darling, Chad E; Fisher, Kimberly A; McManus, David D; Coles, Andrew H; Spencer, Frederick A; Gore, Joel M; Goldberg, Robert J

2013-01-01

Chad E Darling,1 Kimberly A Fisher,2 David D McManus,3,4 Andrew H Coles,5 Frederick A Spencer,5,6 Joel M Gore,3,4 Robert J Goldberg31Department of Emergency Medicine, 2Division of Pulmonary Critical Care, 3Department of Quantitative Health Sciences, 4Department of Medicine, 5Program for Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA, USA; 6Department of Medicine, McMaster University, Hamilton, Ontario, CanadaBackground: Limited recent data are availabl...

Seguimiento a patógenos presentes en biosólido empleado como enmienda para revegetalizar un talud

OpenAIRE

López Sánchez, Idalia Jacqueline; Acevedo Cifuentes, Diana Rocío; Ordóñez Ante, Carlos Andrés

2010-01-01

Con el fin de evaluar la factibilidad del uso del biosólido como enmienda orgánica para el establecimiento de vegetación y el control de procesos erosivos superficiales activos, se seleccionó un corte de carretera ubicado sobrela Variante a Caldas (Antioquia). Para darle amarre y cobertura al suelo, se sembraron dos especies vegetales tipo pasto Brachiaria Decumbens y Kikuyo (Pennisetum clandestinum), utilizando biosólido proveniente de la PTAR San Fernando, mezclado con suelo de la zon...

Rutas gastronómicas chilenas : una aproximación al tema

Directory of Open Access Journals (Sweden)

Alfredo Ascanio

2009-01-01

En el artículo se parte de la premisa que la geografía recreativa consiste en darle valor al paisaje cultural en su sentido amplio. La gastronomía no es más que un elemento de esos paisajes que se deben ofrecer de una manera sistémica y no aislada. Este artículo se ha basado en la literatura ya existente de ensayistas y poetas chilenos que han enriquecido sus propias experiencias con el conocimiento cabal de su territorio.

Historia de la animación

Directory of Open Access Journals (Sweden)

Juan Ruiz

2015-01-01

Full Text Available Desde hace varios años se ha venido trabajando en darle movimiento a las imágenes dibujadas o pintadas. Este artículo expone una síntesis del desarrollo de los dibujos animados desde que el hombre primitivo, impresionado por los movimientos de los animales que cazaba, plasmó estas acciones en las pinturas rupestres de las grutas de Lascaux en Francia, o las de Altamira en España, hasta los creados por la genialidad de Walt Disney.

Marine Corps Provisioning Policy Review Staff Study Report.

Science.gov (United States)

1980-10-28

H.DErw,MCLB,Albany,Ga. major P.P.Darling,Hr.MC,Cb) de LPP Captain D.L. Chadwick,HOMC,Cocle LIPS Captain C.G.Durand,HCMC,Cbde M Mr.K.R.Storms,HQt4C...8217ros:iZicnir." packaoes for selected: iti . h.ve bZen a.-: .. c - .. as a c:$Jter tao? file. " ioa s ... been reqiestei frcm Alanv for inclusion in tniz...the orograns develoo:-5 to calculate the measures of effectiveness. The likelihood of programaing errors increases withcomplexity, thereby extending

Aportes al desarrollo sostenible desde la identificación de la problemática de los residuos de aparatos eléctricos y electrónicos hospitalarios en 24 hospitales de Bogotá-Colombia

OpenAIRE

Díaz Franky, María Carolina

2017-01-01

Artículo (Maestría en Desarrollo Sostenible y Medio Ambiente). Universidad de Manizales. Facultad de Ciencias Contables, Económicas y Administrativas. CIMAD, 2016 Los residuos de aparatos eléctricos y electrónicos - RAEE tipo biomédicos, tienen diferencias en cuanto a cantidades generadas en cada hospital y en las formas de darles manejo, lo cual trae como consecuencia riesgos para el ambiente y salud. Se pretende conocer la problemática generando una propuesta de aportes al desarrollo sos...

Clima organizacional y el alineamiento estratégico en los trabajadores administrativos y asistenciales de la Clínica Good Hope, Lima, 2016.

OpenAIRE

Chilón Troncos, Ronny Francisco

2016-01-01

El objetivo del estudio fue determinar la relación entre clima organizacional y el alineamiento estratégico de los trabajadores administrativos y asistenciales, en la Clínica Good Hope, Lima, cuyos tipos son: descriptivo, transversal y correlacional, con enfoque no experimental, en una población de 1000 trabajadores y una muestra de 127, seleccionados y elegidos por conveniencia. Para darle consistencia teórica, se abordaron teorías sobre el clima organizacional y plan estratégico. Existe una...

La “seguridad” depredadora/Depredator “security”

Directory of Open Access Journals (Sweden)

Augusto Sánchez Sandoval (México

2014-08-01

Full Text Available Se analizan diversas definiciones de “seguridad” con el fin de darle contexto, a la aquí llamada “seguridad depredadora”, para desenmascarar los abusos de poder y la mala fe de los discursos político-jurídicos sobre el respeto a los Derechos Humanos. Different definitions of "security" are analysed in order to give context to the here called "predatory security", to expose abuses of power and bad faith of the politic-legal speeches on respect for human rights.

Leishmaniosis laríngea recidivante: un caso inusual en un paciente inmunocompetente tratado con corticoides Recidivant laryngeal leishmaniosis: an unusual case in an immunocompetent patient treated with corticosteroids

Directory of Open Access Journals (Sweden)

R. Casero

2010-06-01

Full Text Available La leishmaniosis es una parasitosis de evolución crónica; en Argentina, sus agentes etiológicos principales pertenecen al complejo Leishmania (Viannia braziliensis, habitualmente asociado a lesiones cutáneas y mucocutáneas. Informamos en este trabajo un caso de leishmaniosis laríngea en un hombre de 29 años procedente de Jujuy, quien a raíz de múltiples subdiagnósticos portaba esta parasitosis desde hacía 20 años. En el año 2008 este paciente consulta por disfonía crónica y trastornos en las vías aéreas superiores, refiere que fue sometido a terapias con tuberculostáticos, antifúngicos y corticoides desde 2002. Diferentes biopsias y fibroscopías revelaron los siguientes diagnósticos: laringitis granulomatosa inespecífica, laringitis compatible con tuberculosis, laringitis compatible con histoplasmosis, linfoma Natural Killer extraganglionar a células pequeñas. Finalmente, estudios realizados en nuestro hospital demostraron la presencia de una laringe granulomatosa en toda su extensión, amastigotes intra y extracelulares de Leishmania spp., ausencia de formas compatibles con Micobacterias e Histoplasma, y laringitis crónica vinculable a Leishmania spp. El paciente realizó tratamiento con antimoniato de N-metil-glucamina y demostró una muy buena evolución clínica tras ser examinado 2 meses después. Si bien la leishmaniosis laríngea como lesión única no es la presentación prevalente de esta zoonosis, su estudio amerita especial atención en pacientes tratados con corticoides, pues esto evitará un diagnóstico tardío y las mayores consecuencias asociadas a la morbimortalidad propia de esta parasitosis.Leishmaniosis is a chronic parasitic disease, which in Argentina is mainly caused by protozoa belonging to the Leishmania (Viannia braziliensis complex, leading to cutaneous and mucosal pathologies. We report a rare case of laryngeal leishmaniosis in a 29 year-old man from Jujuy province, Argentina, who had been

Geomorphology of the Namoi alluvial plain, northwestern New South Wales

International Nuclear Information System (INIS)

Young, R.W.; Young, A.R.M.; Price, D.M.; Wray, R.A.L.

2002-01-01

The Quaternary history of the extensive alluvial plains of the northern part of the Darling River Basin has received little attention, and has generally been assumed to be an analogue of the very detailed history compiled for the Riverine Plain of southeastern Australia. Our study of the Namoi valley, which is a tributary to the upper Darling, shows that this assumption is unfounded. Thermoluminescence dating demonstrates that the oldest palaeochannels of the Namoi River correspond only to the youngest palaeochannels on the Riverine Plain. The thermoluminescence analyses were carried out on the 90-125 μm quartz fraction thermally stimulated by ionizing radiation using the combined additive/regenerative technique. This technique utilises a second glow normalisation procedure that involves re-irradiating each of the quartz sample aliquots and measuring the thermoluminescence induced in the grains. It has ben demonstrated that unlike the streams on the Riverine Plain, the Namoi River has moved progressively away from its buried Tertiary palaeovalley, probably due to declining sediment input from its southern tributaries. In contrast to the streams of the Riverine Plain, the dimensions of the Namoi palaeochannels are indicative of substantially greater discharges until the mid-Holocene. There is also evidence of significant aeolian input throughout the Late Quaternary. The study indicates that the water resources of this increasingly important irrigated region seem to be considerably constrained by the Quaternary heritage of the Namoi valley. Copyright (2002) Geological Society of Australia

The role of integrative taxonomy in the conservation management of cryptic species: the taxonomic status of endangered earless dragons (Agamidae: Tympanocryptis in the grasslands of Queensland, Australia.

Directory of Open Access Journals (Sweden)

Jane Melville

Full Text Available Molecular phylogenetics is increasingly highlighting the prevalence of cryptic species, where morphologically similar organisms have long independent evolutionary histories. When such cryptic species are known to be declining in numbers and are at risk of extinction due to a range of threatening processes, the disjunction between molecular systematics research and conservation policy becomes a significant problem. We investigate the taxonomic status of Tympanocryptis populations in Queensland, which have previously been assigned to T. tetraporophora, using three species delimitation approaches. The taxonomic uncertainties in this species-group are of particular importance in the Darling Downs Earless Dragon (T. cf. tetraporophora, which is ranked as an endangered 'species' of high priority for conservation by the Queensland Department of Environment and Heritage Protection. We undertook a morphological study, integrated with a comprehensive genetic study and species delimitation analyses, to investigate the species status of populations in the region. Phylogenetic analyses of two gene regions (mtDNA: ND2; nuclear: RAG1 revealed high levels of genetic divergence between populations, indicating isolation over long evolutionary time frames, and strongly supporting two independent evolutionary lineages in southeastern Queensland, from the Darling Downs, and a third in the Gulf Region of northern Queensland. Of the three species delimitation protocols used, we found integrative taxonomy the most applicable to this cryptic species complex. Our study demonstrates the utility of integrative taxonomy as a species delimitation approach in cryptic complexes of species with conservation significance, where limited numbers of specimens are available.

The role of integrative taxonomy in the conservation management of cryptic species: the taxonomic status of endangered earless dragons (Agamidae: Tympanocryptis) in the grasslands of Queensland, Australia.

Science.gov (United States)

Melville, Jane; Smith, Katie; Hobson, Rod; Hunjan, Sumitha; Shoo, Luke

2014-01-01

Molecular phylogenetics is increasingly highlighting the prevalence of cryptic species, where morphologically similar organisms have long independent evolutionary histories. When such cryptic species are known to be declining in numbers and are at risk of extinction due to a range of threatening processes, the disjunction between molecular systematics research and conservation policy becomes a significant problem. We investigate the taxonomic status of Tympanocryptis populations in Queensland, which have previously been assigned to T. tetraporophora, using three species delimitation approaches. The taxonomic uncertainties in this species-group are of particular importance in the Darling Downs Earless Dragon (T. cf. tetraporophora), which is ranked as an endangered 'species' of high priority for conservation by the Queensland Department of Environment and Heritage Protection. We undertook a morphological study, integrated with a comprehensive genetic study and species delimitation analyses, to investigate the species status of populations in the region. Phylogenetic analyses of two gene regions (mtDNA: ND2; nuclear: RAG1) revealed high levels of genetic divergence between populations, indicating isolation over long evolutionary time frames, and strongly supporting two independent evolutionary lineages in southeastern Queensland, from the Darling Downs, and a third in the Gulf Region of northern Queensland. Of the three species delimitation protocols used, we found integrative taxonomy the most applicable to this cryptic species complex. Our study demonstrates the utility of integrative taxonomy as a species delimitation approach in cryptic complexes of species with conservation significance, where limited numbers of specimens are available.

Proceso de construcción de la identidad del adolescente que consulta en la Comisaría de Familia de la ciudad de Manizales

OpenAIRE

Pinilla Amador, Claudia Patricia

2000-01-01

Tesis de grado (Maestría en Pedagogías Activas y Desarrollo Humano). Centro Internacional de Educación y Desarrollo humano -Cinde-Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2000 La investigación desarrollada se implementa dentro de la perspectiva Histórico Hermenéutica, busca darle un sentido a la información obtenida a través de instrumentos como una guía de registro y análisis, la entrevista, la historia de vida y la prueba de autoconcepto de Tennessee; utiliza...

Contabilidad de costos ambientales en la industria cárnica, recomendaciones para su desarrollo

OpenAIRE

Yunier Maresma-Hernández

2016-01-01

La contabilidad ambiental ha logrado darle un matiz económico y financiero al uso, cuidado y conservación del medio ambiente, convirtiéndose esta, en una valiosa herramienta para la toma de decisiones, generando beneficios tanto para las organizaciones como para el medio natural. Es por tal razón que se enfoca este trabajo al estudio de los sistemas de costos empleados por la industria cárnica; tomando como estudio de caso la Empresa Cárnica Holguín. Para la realización de la investigación se...

Del Diseño 2D al diseño digital

OpenAIRE

Enrique Chiroque

2014-01-01

En un inicio, hablar de Diseño Gráfico involucraba un proceso editorial interesante, comprendiendo desde la idea inicial hasta el producto impreso. Luego, conforme fue evolucionando, pasamos a otras plataformas adicionales a la impresa, como productos digitales y audiovisuales. Considero que, en el proceso de crear y darle movimiento a un personaje en 3D, me involucro aún más en el mundo de la animación y fue justamente que este proceso de cambios se presentó de manera progresiva a la par que...

Colombia y el transpacific partnership agreement

OpenAIRE

Navarro León, Karen Sofía

2015-01-01

Colombia, a partir de 1990, inicia un plan de gobierno enfocado en la apertura económica, con estrategias que propugnaban por un cambio en el modelo económico a través de políticas como la reducción de aranceles a las importaciones y otra serie de medidas proteccionistas, flexibilización laboral, la reducción del papel del Estado para darle protagonismo al sector privado y procesos de privatización de empresas públicas En este entorno internacional se ha adquirido conciencia de que, en un...

Amenazas actuales a la institucionalidad electoral en América Latina: La experiencia panameña

OpenAIRE

Eduardo Valdés Escoffery

2017-01-01

Analiza la reforma constitucional de Panamá de 2004 y el conflicto de competencias que genera al darle a la Corte Suprema de Justica la facultad exclusiva para juzgar penalmente a los diputados, sin excepción por tipo de delito. Por tal motivo, juzgará también los delitos electorales y por ende de forma implícita tendrá la potestad de interpretar la normativa electoral; competencia privativa del Tribunal Electoral desde su creación en el año 1956, donde se le asigna la jurisdicción de interpr...

Teleportation the impossible leap

CERN Document Server

Darling, David

2005-01-01

An authoritative, entertaining examination of the ultimate thrill ride Until recently the stuff of sci-fi fiction and Star Trek reruns, teleportation has become a reality-for subatomic particles at least. In this eye-opening book, science author David Darling follows the remarkable evolution of teleportation, visiting the key labs that have cradled this cutting-edge science and relating the all-too-human stories behind its birth. He ties in the fast emerging fields of cryptography and quantum computing, tackles some thorny philosophical questions (for instance, can a soul be teleported?)

Un plan de acción para incrementar la incorporación de las embarazadas al programa de psicoprofilaxis con actividad física

Directory of Open Access Journals (Sweden)

Rafaela Montero Lafargue

2017-11-01

Full Text Available El artículo contiene un plan de acción para incrementar la incorporación de las embarazadas al programa de psicoprofilaxis con actividad física. Para darle solución al objetivo propuesto se utilizaron métodos de nivel teórico, empírico y estadístico, logrando el trabajo conjunto del equipo multidisciplinario de salud en la atención a embarazadas, permitiendo incrementar su articipación en la actividad física del programa de psicoprofilaxis.

Sra. Clemencia Restrepo de Vergara

Directory of Open Access Journals (Sweden)

Efraím Otero Ruiz

2006-06-01

Fue una de tantas damas, la mayoría de las cuales aún nos acompañan, que han sabido darle a esta centenaria Academia un aire como de “gran familia” en la que nos sentimos acogidos, aunque ya no enciendan con la debida frecuencia una de sus cálidas y enormes chimeneas. Esa calidez es la que permanece en el espíritu de todos los que conocimos a Clemencia. Por eso van para Roberto, sus admirables hijos y todos sus familiares, nuestros votos de solidaridad y sincera condolencia...

La ciudad musulmana y la influencia del urbanismo occidental en su confirmación

OpenAIRE

Suleiman Shinaq, Mazen

2011-01-01

La ciudad musulmana se estudia como algo misterioso, encerrado dentro de sus muros, lo que despertó la curiosidad de los investigadores por descifrar este misterio y por despojar del antifaz a las distintas fases de su evolución, no sólo por la peculiaridad que supone el modelo urbanístico musulmán, sino también por su aportación al urbanismo universal. El objetivo de este estudio consiste en comprobar por una parte, el debate abierto sobre el papel del Islam como religión urbana al darle...

Liderazgo y autoeficacia en el comportamiento organizacional positivo

OpenAIRE

Sanchez Hernandez, Maria Paula; Pinto Erazo, Laura María; Contreras Ruiz, Ivan Camilo

2016-01-01

El objetivo que tiene este proyecto es revisar los conceptos básicos acerca de las relaciones que crean los líderes con sus colaboradores dentro de las organizaciones, dichas relaciones y vínculos pueden afectar positiva o negativamente el desempeño de sus actividades diarias dentro de una organización. Para darle inicio a la investigación se estudió como primer paso el concepto de liderazgo transformacional, capital psicológico y que componentes hacían parte de este factor. El desarrollo ...

Los Primeros Auxilios en la escuela

OpenAIRE

Gas Ferrando, David; Safont Babiloni, David

2015-01-01

Treball Final de Grau en Mestre o Mestra d'Educació Primària. Codi: MP1040. Curs acadèmic 2014-2015 Los primeros auxilios son los cuidados que podemos darle a una persona que acaba de tener un accidente y tratamos de mejorar su salud mientras llega la asistencia sanitaria. Por ello, es de vital importancia tener unas nociones básicas sobre estos, con el fin de saber cómo debemos actuar ante una situación de accidente. La mejor manera de que toda la población, adquiera conocimie...

UN PRIVILEGIO PARA EL ESTADO DE MICHOACÁN: SUS PUEBLOS MÁGICOS

OpenAIRE

Horacio Mercado Vargas; Edgar Allan Mercado Flores

2013-01-01

El Estado de Michoacán, que se ubica en la parte del extremo sur occidental de México, posee paisajes muy hermosos: de bosques, praderas y lagunas de gran belleza, montañas y volcanes que descienden hacia el mar. Es uno de los más ricos en recursos naturales. La Secretaría de Turismo, diversas entidades del gobierno federal y gobiernos estatales y municipales desarrollaron el Programa de Pueblos Mágicos, para darle un valor a ciertas poblaciones del país que tienen características culturales ...

Automatización Fuzzy aplicado en la contabilidad decisional

OpenAIRE

Jaime Tinto Arandes; María Emilia Molina; Habbid Chávez Acosta; Sylvia Mosquera Maldonado

2016-01-01

El propósito de este trabajo es introducir la automatización en los instrumentos que la teoría de la incertidumbre contiene, dentro de las ciencias contables como herramienta fundamental para la toma de decisiones debido a la necesidad de darle al área contable una visión predictiva y dinámica. Con ello se pretende ir introduciendo los conceptos de la teoría de la incertidumbre para la construcción de los balances previsionales de situación y unos estados previsionales de resultados, donde qu...

Control de legalidad en la formulación de la acusación en el sistema penal acusatorio colombiano

OpenAIRE

Orozco Villamizar, Raul; Suarez Ayala, Juan Carlos

2015-01-01

En el sistema procesal acusatorio colombiano al legislar el inicio formal de la etapa del juicio omitió darle un espacio para el control judicial al escrito de acusación, argumentándose que esa era precisamente una expresión de la división de funciones entre investigación y juzgamiento, empero cierto es que una ausencia absoluta de control de la acusación hace nugatoria la posibilidad de la tutela real efectiva que como principio dentro del marco del derecho al debido proceso constitucional s...

La política pública de seguridad en las edificaciones y los factores que condicionan su cumplimiento en Lima Metropolitana

OpenAIRE

Arroyo Núñez, Nancy Esther

2017-01-01

La inseguridad en las edificaciones de Lima Metropolitana, caracterizada básicamente por el incumplimiento de las reglas de seguridad en edificaciones, no se ha logrado erradicar hasta el día de hoy. La política construida para darle término fue pensanda en un público formal, sin considerar que más del 90% de los empresarios en el Perú es informal. La obligatoriedad de someter a los establecimientos que desarrollan cualquier actividad económica a las Inspecciones Técnicas de Seguridad (ITS...

El capital social y su tratamiento en las entidades en las entidades de ahorro y crédito popular sobre la base de la normativa contable internacional

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Luis Carlos Gámez Adame

2013-03-01

Full Text Available Las Entidades de Ahorro y Crédito Popular (Cooperativas constituyen un segmento importante dentro de los servicios financieros que se prestan en diferentes países y que han tenido un desarrollo vertiginoso al satisfacer demandas y necesidades de numerosas masas poblacionales.Se presentan algunas consideraciones asociadas al tratamiento del capital social en estas entidades sobre la base de la normatividad contable internacional vigente y donde a criterio de los autores existen una serie de incongruencias a las que hay que darles solución.

Enhancing pathogen identification in patients with meningitis and a negative Gram stain using the BioFire FilmArray(®) Meningitis/Encephalitis panel.

Science.gov (United States)

Wootton, Susan H; Aguilera, Elizabeth; Salazar, Lucrecia; Hemmert, Andrew C; Hasbun, Rodrigo

2016-04-21

Meningitis with a negative cerebrospinal (CSF) Gram stain represents a diagnostic and therapeutic challenge. The purpose of our study was to evaluate the performance of the BioFire FilmArray(®) Meningitis/Encephalitis (FA ME) panel in patients presenting with community-acquired meningitis with a negative Gram stain. CSF from 48 patients with community-acquired meningitis with a negative Gram stain admitted to four hospitals in Houston, TX underwent additional testing by the FA ME. FA ME results were compared to results obtained as part of routine evaluation. The panel detected pathogens not previously identified in 11 (22.9 %) of 48, but did not detect pathogens identified by standard technique (West Nile virus, Histoplasma) in 5 (15.2 %) patients. Rapid testing for the most common pathogens causing meningitis will aid in the diagnosis and treatment of patients with meningitis.

75 FR 27576 - J.N. “Ding” Darling National Wildlife Refuge, Lee County, FL

Science.gov (United States)

2010-05-17

... wildlife and habitat diversity and the minimization of human impacts on these resources. In general... and lack of a comprehensive habitat management plan; and (8) insufficient resources to address refuge... (Native Wildlife and Habitat Diversity) Alternative B would expand or initiate our management activities...

How to put your darlings on a diet. Philosophical practice as an epistemological practice

DEFF Research Database (Denmark)

Lystbæk, Christian Tang

Today, health care organizations are changing in several ways. New technologies, new audit regimes and new relationships with clients of various kinds all contribute to altering what it takes to perform in health care organizations. Consequently, one of the characteristics of health care organiza......Today, health care organizations are changing in several ways. New technologies, new audit regimes and new relationships with clients of various kinds all contribute to altering what it takes to perform in health care organizations. Consequently, one of the characteristics of health care...... that is spreading, but also ways of engaging with knowledge, historically associated with research communities. This contribution to the 5th Nordic Conference on Philosophical Practice describes how Philosophical Practice can enter the epistemic practices in health care organizations by inviting an open...

Goodness-of-Fit Tests for Generalized Normal Distribution for Use in Hydrological Frequency Analysis

Science.gov (United States)

Das, Samiran

2018-04-01

The use of three-parameter generalized normal (GNO) as a hydrological frequency distribution is well recognized, but its application is limited due to unavailability of popular goodness-of-fit (GOF) test statistics. This study develops popular empirical distribution function (EDF)-based test statistics to investigate the goodness-of-fit of the GNO distribution. The focus is on the case most relevant to the hydrologist, namely, that in which the parameter values are unidentified and estimated from a sample using the method of L-moments. The widely used EDF tests such as Kolmogorov-Smirnov, Cramer von Mises, and Anderson-Darling (AD) are considered in this study. A modified version of AD, namely, the Modified Anderson-Darling (MAD) test, is also considered and its performance is assessed against other EDF tests using a power study that incorporates six specific Wakeby distributions (WA-1, WA-2, WA-3, WA-4, WA-5, and WA-6) as the alternative distributions. The critical values of the proposed test statistics are approximated using Monte Carlo techniques and are summarized in chart and regression equation form to show the dependence of shape parameter and sample size. The performance results obtained from the power study suggest that the AD and a variant of the MAD (MAD-L) are the most powerful tests. Finally, the study performs case studies involving annual maximum flow data of selected gauged sites from Irish and US catchments to show the application of the derived critical values and recommends further assessments to be carried out on flow data sets of rivers with various hydrological regimes.

Log-stable concentration distributions of trace elements in biomedical samples

International Nuclear Information System (INIS)

Kubala-Kukus, A.; Kuternoga, E.; Braziewicz, J.; Pajek, M.

2004-01-01

In the present paper, which follows our earlier observation that the asymmetric and long-tailed concentration distributions of trace elements in biomedical samples, measured by the X-ray fluorescence techniques, can be modeled by the log-stable distributions, further specific aspects of this observation are discussed. First, we demonstrate that, typically, for a quite substantial fraction (10-20%) of trace elements studied in different kinds of biomedical samples, the measured concentration distributions are described in fact by the 'symmetric' log-stable distributions, i.e. the asymmetric distributions which are described by the symmetric stable distributions. This observation is, in fact, expected for the random multiplicative process, which models the concentration distributions of trace elements in the biomedical samples. The log-stable nature of concentration distribution of trace elements results in several problems of statistical nature, which have to be addressed in XRF data analysis practice. Consequently, in the present paper, the following problems, namely (i) the estimation of parameters for stable distributions and (ii) the testing of the log-stable nature of the concentration distribution by using the Anderson-Darling (A 2 ) test, especially for symmetric stable distributions, are discussed in detail. In particular, the maximum likelihood estimation and Monte Carlo simulation techniques were used, respectively, for estimation of stable distribution parameters and calculation of the critical values for the Anderson-Darling test. The discussed ideas are exemplified by the results of the study of trace element concentration distributions in selected biomedical samples, which were obtained by using the X-ray fluorescence (XRF, TXRF) methods

Bidirectional Associations between Bedtime Parenting and Infant Sleep: Parenting Quality, Parenting Practices, and their Interaction

Science.gov (United States)

Philbrook, Lauren E.; Teti, Douglas M.

2016-01-01

In keeping with transactional conceptualizations of infant sleep development (Sadeh et al., 2010), the present study examined longitudinal, bidirectional linkages between bedtime parenting (direct observations of parenting practices and quality) and infant sleep across the first six months postpartum. In doing so, we also drew from Darling and Steinberg's (1993) conceptual model to examine parenting quality as a moderator of linkages between specific bedtime practices and infant sleep. Multilevel model analyses revealed that the strongest increases in infant nighttime sleep across the first six months occurred among infants of mothers who engaged in low levels of nursing at bedtime. Within-person linkages between mothers' emotional availability (EA) at bedtime, infant distress, and infant sleep were found, such that at time points when mothers were more emotionally available, infants were less distressed and slept more throughout the night. Several moderating effects of maternal EA on linkages between parenting practices and infant sleep were obtained that were consistent with predictions from Darling and Steinberg (1993). Higher maternal EA in combination with less close contact at bedtime was associated with more infant sleep across the night on average, and higher EA in combination with fewer arousing bedtime activities predicted more rapid increases in infant sleep with age. Finally, there was evidence of infant-driven effects, as higher infant nighttime distress predicted lower EA at subsequent time points. Results showcased the complex, reciprocal interplay between parents and infants in the development of infant sleep patterns and parenting behavior during the first six months postpartum. PMID:27010601

SOME OBJECTS OF MEANING RELATED TO LOVER IN THE DIVAN OF BAKI BÂKÎ DÎVÂNI’NDA ÂŞIK İLE İLGİLİ BAZI ANLAM UNSURLARI

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Meheddin İSPİR

2010-07-01

Full Text Available Lover is one of the most important factors in Divan poem. The position of lover before the darling is handed and studied on in a clear frame. The lover is a slave and servant. İt suffers from living alone without darling and tolarate the fortune derived from loved one. İt is miserable, indulgent and poor. But it exists with all these features and tries to make everybady know that it than the other ones with the same features. İn this study the features of the lovers and some other similar features were handed and studied on. Âşık divan şiirinin en önemli unsurlarından biridir. Âşığın sevgili karşısındaki konumu belli bir çerçevede ele alınır ve işlenir. Âşık sevgili karşısında kuldur, köledir. Sevgiliden ayrı olmanın acısını çeker, sevgiliden gelen eziyetlere katlanır. Perişan, düşkün ve yoksuldur. Ancak o bütün bu özellikleriyle vardır ve bu özelliklerle âşık olduğunu hatta diğer âşıklardan daha üstün olduğunu ispatlamaya çalışır. Âşık ile ilgili bu ve buna benzer özellikler ele alınıp değerlendirildi.

Cuidados de enfermería en el paciente de revascularizacion miocárdica con circulación extracorpórea

Directory of Open Access Journals (Sweden)

Ruby Elizabeth Vargas-Toloza

2004-12-01

Full Text Available La presente revisión pretende mostrar la complejidad del trabajo de enfermería con los pacientes sometidos a cirugías cardiovasculares, donde el plan de atención antes y después del procedimiento hace parte del éxito y recuperación del paciente. Siendo los síndromes coronarios agudos, una de las primeras causas de muerte a nivel mundial, se ha hecho el mayor esfuerzo por darle solución a este problema como lo son la cirugía de revascularización miocardica con circulación extracorporea.

Redalyc: una alternativa a las asimetrías en la distribución del conocimiento científico

OpenAIRE

Eduardo Aguado López; Rosario Rogel Salazar; Gustavo Garduño Oropeza; María Fernanda Zúñiga

2008-01-01

En el presente artículo se analiza el problema de la distribución asimétrica del conocimiento científico, partiendo del supuesto de que las revistas especializadas son el principal medio para la comunicación científica, por lo que a través de ellas se legitima el conocimiento. De ahí la importancia de apoyar los proyectos regionales que buscan darles visibilidad y coadyuvar a la consolidación de los procesos editoriales. El Sistema de Información Científica Redalyc (SICR) es uno de estos proy...

Edificio de apartamentos, Cuba

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Fernández, Emilio

1961-07-01

Full Text Available La obra consta de dos plantas iguales y en cada una de ellas se distribuyen dos apartamentos: uno de tres dormitorios, dos baños., portal, sala, comedor, cocina, patio de servicio y W.C. de servicio; otro, al fondo, con sala-comedor, dos dormitorios, cocina y patio de servicio. Los portales y patios de servicios han sido cerrados casi totalmente por medio de celosías, con objeto de darles un carácter privado y protegerlos de la exposición directa del sol, evitando así los inconvenientes de nuestro clima.

Ukola Club. Bar americano

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Azpiazu, J. R.

1961-03-01

Full Text Available En la calle de Serrano, aprovechando un semisótano dedicado a otro negocio anteriormente, se ha instalado un bar americano, de cuyo interior ofrecemos algunos pormenores. Se han cuidado, especialmente, las condiciones acústicas, resueltas por medio de un techo de escayola perforada, con vitrofib en su parte superior, y paredes de madera, que contribuyen a darle un ambiente cálido y acogedor. El soporte de hierro laminado existente en el centro del local, cuya supresión hubiera sido costosa, se ha revestido con lajas de mármol que le convierten en un elemento decorativo.

UNA ACUSTEMOLOGÍA DE LA SELVA TROPICAL

OpenAIRE

FELD, STEVEN

2013-01-01

Este texto tiene por objeto darle voz a un tipo de realidad alterna, a un tipo de sensibilidad sonora que he encontrado a través de la investigación antropológica de una ecología del lenguaje, la música y la acústica. La esperanza es que, al dar a las voces marginadas espacios desde donde hablar, gritar y cantar, la antropología podrá contrarrestar en alguna medida la arraigada arrogancia de la autoridad colonial e imperial, de la historia escrita en una sola lengua, a una sola voz, como una ...

Fábrica de paños en Tunja, en el siglo XVIII

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Sergio Elías Ortíz

1968-05-01

Full Text Available Con los pocos datos que se tiene respecto del desarrollo de la manufactura de tejidos en los tiempos coloniales, parece que pudiera corresponder a los señores Juan Manuel de Muelle y Pedro Hernández de Zurita el honor de haber sido los iniciadores en nuestra patria de la industria de textiles, ramo que ellos trataron de sacar del ámbito familiar para darle categoría de industria cuando menos regional, con carácter de fábrica para producción en masa y empleo de muchos brazos para las labores.

Casos prácticos Normativa APA 6ª ed.

OpenAIRE

Guerras-Frías, Miroslava (tr)

2010-01-01

A la hora de realizar un trabajo es importante leer otros documentos relacionados para ver el estado de la cuestión, además de apoyarte en sus teorías para darle valor y peso a tu trabajo. Pero todo trabajo que este basado en otros debe de citar y tener sus referencias bibliográficas normalizadas. Para esto hay muchos estilos validos normalizados, el que aquí nos ocupa es sobre el estilo de la American Psychological Association, más conocido como Nomas o Estilo APA de la 6ª edición.

Minería para el desarrollo

OpenAIRE

Castroviejo Bolibar, Ricardo

1997-01-01

Este trabajo continúa la reflexión presentada por el autor en esta revista (número Noviembre-Diciembre 1995, pág. 76-78), aportando nuevos datos y propuestas, a fin de completarla y darle cuerpo en proyectos concretos. El sector minero se enfrenta en un futuro próximo, según recientes previsiones económicas (E&MJ,1995 b), a un notable crecimiento, comparable al boom de los años 50/70, motivado en gran parte por las demandas de nuevos países en proceso acelerado de industrialización. Esto cont...

A mi pintura le gustaría llegar a la textura de la piedra, de un árbol o del agua

Directory of Open Access Journals (Sweden)

Kindi Llajtu

2014-09-01

Full Text Available Kindi Llajtu viene trabajando con las huellas que encuentra y las que él mismo produce y deja atrás por medio de intervenciones en el espacio, los cuerpos y las superficies. Recuperar los rastros del pueblo Inga al que pertenece, sus antiguos objetos, sus comidas, sus fiestas, para darles nueva vivacidad o hacerlos desvanecer de una nueva manera, tiene por finalidad generar y jugar con las texturas del recuerdo que cubre y descubre todo; hacer texturas que evidencian el paso del tiempo y sus fantasmas que lo van puliendo, tejiendo y transformando todo.

Obesidad y sus co-morbilidades: estrategias desde la actividad física

OpenAIRE

Lhuillier, Geraldine

2013-01-01

La obesidad fue declarada en el año 1997 por la OMS la epidemia del siglo XXI, siendo la enfermedad no transmisible más prevalente en el mundo. En virtud de esta situación, surge la necesidad de conocer aspectos relevantes de esta patología, para darle un correcto abordaje en su tratamiento a través de la actividad física, basado en la evidencia científica. Se acepta que el efecto del ejercicio físico en la pérdida de peso es generalmente modesto, sin embargo, es significativo su valor com...

Estudio longitudinal de la evolución y la forma como se relaciona TPM con el SPR y su modelo de integración al sistema industrial en una empresa del sector automotriz –Renault-SOFASA–

OpenAIRE

Aguirre Muñoz, Marytzabel

2011-01-01

El presente estudio tiene como fin actualizar al año 2010 las dinámicas de cambio seguidas en la implantación de Mantenimiento Productivo Total (TPM) en una empresa ensambladora de automóviles (Renault-Sofasa), reuniendo los aspectos más relevantes que influyeron en darle a TPM un nuevo enfoque, integrándolo completamente a los procesos de la compañía y al sistema industrial y direccionándolo a contribuir directamente en la consecución de los objetivos corporativos en un período de tiempo com...

La renovación curricular en el programa de Medicina de la Universidad de Antioquia Curricular renovations in the medical program at the university of Antioquia, in Medellin, Colombia

OpenAIRE

Carlos Aguirre Muñoz; Angela María Arango Rave; Elsa María Villegas Múnera

2007-01-01

En este artículo se hace un análisis de la renovación curricular en el programa de medicina de la Universidad de Antioquia, especialmente entre los años 2000 y 2005, cuyo propósito se enfocaba en pasar de una concepción tRadicional y tecnológica del currículo a una tendencia integracionista, centrada en el estudiante, flexible, enfocada en los procesos cognitivos y en lograr la formación de un médico capaz de darles respuesta a las necesidades sociales locales y globales. Se analizan la imple...

Realidad aumentada en fisiología: descarga y breves instrucciones del uso de la aplicación HP REVEAL (AURASMA) sobre marcadores de nivel 1 y 2 en la docencia

OpenAIRE

Domínguez Vías, Germán; Carrasco Viñuela, Manuel; González Forero, David; Portillo Pacheco, Federico Luís; Vallo de Castro, Jose Juan

2018-01-01

Diálogo (Script): - Hola a todos. Una vez descargada la aplicación Aurasma, ahora llamada HP Reveal, tendréis que pulsar la aplicación, app AURASMA, y buscar y darle a seguir al grupo fisiologiaUCA. A continuación, podréis probar en clase activando el escáner y enfocando sobre marcadores de realidad aumentada de nivel 1, como código, o al final de este video marcadores de nivel 2, como son las fotos. Os saldrán, como estáis viendo, animaciones que os ayudarán a ver y comprender conceptos ...

Validez del modelo bidimensional de socialización parental en diferentes entornos sociales de la cultura española : implicaciones para el ajuste psicosocial de los adolescentes

OpenAIRE

Fuentes Durán, María del Castillo

2014-01-01

Durante las últimas décadas, la literatura empírica ha demostrado en repetidas ocasiones la influencia que tienen las diferentes formas de actuación de los padres en el proceso de socialización en el ajuste psicológico y social de los hijos. La investigación en torno a la socialización familiar se ha basado tradicionalmente en el modelo teórico de dos grandes dimensiones teóricamente independientes (aceptación/implicación y severidad/imposición, Darling y Steinberg, 1993; Maccoby y Martin...

El petróleo en el presupuesto general del Estado. Su incidencia en el sistema financiero nacional.

OpenAIRE

Villao Plúa, Karina del Rocío

2017-01-01

La presente investigación muestra como principal objetivo evidenciar la importancia del precio del petróleo en el Presupuesto General del Estado para determinar la situación del Sistema Financiero Nacional. Para el cumplimiento de dicho objetivo, la investigación fue desglosada en 5 capítulos; en el primero de ellos se plantea la situación polémica, así como los objetivos planteados para darle solución a dicha problemática y la metodología aplicada durante la investigación. En el capí...

Análisis sobre la percepción y participación de los profesores de carrera y de planta de la facultad de administración en el plan de desarrollo profesoral ofertada por la Universidad del Rosario

OpenAIRE

Luque Molano, Sonia María; Mondragón Herrera, Diana Milena; Pinzón Zambrano, Nicolás; Castro Mahecha, Javier Mauricio

2013-01-01

En los últimos años, la educación superior ha sufrido cambios que han influenciado directamente en la calidad educativa y el aprendizaje de los estudiantes. Estos procesos se han visto afectados en una evolución metodológica gracias al avance tecnológico a servicio de los estudiantes que es orientada por el cuerpo docente que a su vez ha sido partícipe en dicha evolución. Por su parte la Universidad del Rosario se ha preocupado por darle relevancia a la opinión de los estudiantes, quienes...

Intradermo reacción a la Histoplasmina entre los escolares de Tingo María

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Manuel Villa

1956-07-01

Full Text Available En 1955 se realizó una encuesta entre 696 escolares de las zonas, urbana y rural de Tingo María para investigar la reacción histoplasmínica y tuberculínica en este grupo, con el objeto de conocer el grado de sensibilidad a la histoplasmina que pudiera existir en dicha área. Los resultados obtenidos han sido los siguientes: 1.- El 41.9 por ciento de escolares de la zona de Tingo María. han presentado positividad a la intradermo reacción a la histoplasmina. 2.- Entre el grupo que presentó reacción positiva a la histoplasmina, el 51.7 por ciento mostraron ser negativos a la tuberculina, la que constituye el 21.7 por ciento del total de niños. 3.- La proporción de niños sensibles a la histoplasmina está distribuída uniformemente en toda el área de Tingo María tanto urbana como rural. 4.- El tiempo de residencia en la zona ha demostrado influir en la positividad de la reacción histoplasmínica; esto es, que conforme se prolonga el tiempo de residencia, aumenta la proporción de niños histoplasmino positivos. 5.- Los escolares procedentes de los departamentos de San Martín y Huánuco (excluida la zona de Tingo María han mostrado tener los más altos porcentajes de positividad a la prueba. Hechos los cálculos estadísticos se concluye que estas dos áreas podrían ser también zonas contaminadas por el H. capsulatum. 6. No se ha demostrado en esta encuesta que la "Cueva de las Lechuzas" tenga una influencia mayor que el resto del área de Tingo María para adquirir la sensibilidad a la histoplasmina. Se sugiere realizar posteriores estudios que determinen hasta qué punto la mencionada cueva tiene valor como factor predominante en la epidemiología de la reacción a la histoplasmina. 7. Toda la zona cubierta por la encuesta parece estar contaminada por el H. capsulatum.

Histoplasma com derrame pleural: relato de um caso Histoplasmoma and pleural effusion: a case report

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Marcos C. de Almeida

1990-10-01

Full Text Available Efusões pleurais surgem raramente em associação com a histoplasmose capsu-lata, ocorrendo em geral nas formas agudas da doença. Relatamos e discutimos um caso clínico em que um histoplasmoma subpleural acompanhou-se de dor pleurítica, hidrotórax e pleurite fibrosante.

Potential conflict between the coal and arable land resources in australia: A case for corporate responsiveness

Science.gov (United States)

Langkamp, Peter J.

1985-01-01

Background information on possible surface-coal-mining operations in arable agricultural areas in Australia is provided. The major co-occurrence of the coal and arable land resources was in the Darling Downs region of Queensland and the Liverpool Plains region of New South Wales; however, coal development will probably only occur in the former region over the next decade. Analysis of the situation in the Darling Downs region, which consists of 11 Shires, found five companies conducting prefeasibility projects for surface-coal development and the size of exploration areas concerned far exceeding final mined-land disturbance estimates. Most of the land included in the prefeasibility studies was classified as “arable with moderate crop restrictions requiring intensive management” (classes II IV). The total area of land that may be disturbed at some time in the future was less than 2% of the arable land in the Shires concerned. Project mutual exclusivity and ongoing rehabilitation of disturbed areas further reduce arable land out of production at any one time. It is suggested that, if self-regulation by the coal industry in Australia on rehabilitation issues is to remain a viable option in these areas, an understanding between the corporate and public sectors on the extent and limitations of its responsibilities must be obtained. The current development of a National Conservation Strategy for Australia should assist this to proceed. Research on various rehabilitation issues may be required prior to project commitment to ensure the responsibilities identified are realizable. Integrative problem-solving, incorporating audit procedures, was suggested as a suitable method to achieve these aims and corporate responsiveness was seen as a necessary first step.

Bidirectional associations between bedtime parenting and infant sleep: Parenting quality, parenting practices, and their interaction.

Science.gov (United States)

Philbrook, Lauren E; Teti, Douglas M

2016-06-01

In keeping with transactional conceptualizations of infant sleep development (Sadeh, Tikotzky, & Scher, 2010), the present study was an examination of longitudinal, bidirectional linkages between bedtime parenting (through direct observations of parenting practices and quality) and infant sleep across the first 6 months postpartum. In doing so, we also drew from Darling and Steinberg's (1993) conceptual model to examine parenting quality as a moderator of linkages between specific bedtime practices and infant sleep. Multilevel model analyses revealed that the strongest increases in infant nighttime sleep across the first 6 months occurred among infants of mothers who engaged in low levels of nursing at bedtime. Within-person linkages between mothers' emotional availability (EA) at bedtime, infant distress, and infant sleep were found, such that at time points when mothers were more emotionally available, infants were less distressed and slept more throughout the night. Several moderating effects of maternal EA on linkages between parenting practices and infant sleep were obtained that were consistent with predictions from Darling and Steinberg (1993). Higher maternal EA in combination with less close contact at bedtime was associated with more infant sleep across the night on average, and higher EA in combination with fewer arousing bedtime activities predicted more rapid increases in infant sleep with age. Finally, there was evidence of infant-driven effects, as higher infant nighttime distress predicted lower EA at subsequent time points. Results showcased the complex, reciprocal interplay between parents and infants in the development of infant sleep patterns and parenting behavior during the first 6 months postpartum. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

NOTA EDITORIAL

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Mario Camacho Pinto

1985-04-01

Full Text Available

RESOLUCIÓN

La Presidencia de la Academia Nacional de Medicina, resuelve cambiar y darle una nueva organización a las publicaciones de la institución en la siguiente forma:

1o. Créase el Consejo Editorial compuesto por la Comisión Permanente de Biblioteca y Publicaciones integrada actualmente por los Académicos Mario Camacho Pinto, Juan Di Doménico, Juan Mendoza-Yega, Alvaro López Pardo y Fernando Serpa Flórez.

2o. Se crean los cargos de Editores y se designó como Editor al Académico Mario Camacho Pinto y Coeditor al Académico Alberto Albornoz Plata; y como Editor Asociado al señor Alfonso Yelasco, de la Editorial Catálogo Científico.

3o. Se crea la sección de Editores Asistentes, la cual estará constituida por un grupo de especialistas de las distintas ramas de la medicina representadas en la Academia, estos Editores Asistentes serán nombrados por la Junta Directiva. La misión principal del Editor Mario Camacho Pinto consistirá, además de coordinar las actividades del Consejo Editorial, la de decidir con el Coeditor y el Editor Asociado las publicaciones definitivas que se hayan seleccionado para los Anales. Los Editores Asistentes tendrán como misión especial la revisión de los trabajos científicos que se presenten a la Academia y darles el visto bueno para su publicación en los Anales...

Connecting optical and X-ray tracers of galaxy cluster relaxation

Science.gov (United States)

Roberts, Ian D.; Parker, Laura C.; Hlavacek-Larrondo, Julie

2018-04-01

Substantial effort has been devoted in determining the ideal proxy for quantifying the morphology of the hot intracluster medium in clusters of galaxies. These proxies, based on X-ray emission, typically require expensive, high-quality X-ray observations making them difficult to apply to large surveys of groups and clusters. Here, we compare optical relaxation proxies with X-ray asymmetries and centroid shifts for a sample of Sloan Digital Sky Survey clusters with high-quality, archival X-ray data from Chandra and XMM-Newton. The three optical relaxation measures considered are the shape of the member-galaxy projected velocity distribution - measured by the Anderson-Darling (AD) statistic, the stellar mass gap between the most-massive and second-most-massive cluster galaxy, and the offset between the most-massive galaxy (MMG) position and the luminosity-weighted cluster centre. The AD statistic and stellar mass gap correlate significantly with X-ray relaxation proxies, with the AD statistic being the stronger correlator. Conversely, we find no evidence for a correlation between X-ray asymmetry or centroid shift and the MMG offset. High-mass clusters (Mhalo > 1014.5 M⊙) in this sample have X-ray asymmetries, centroid shifts, and Anderson-Darling statistics which are systematically larger than for low-mass systems. Finally, considering the dichotomy of Gaussian and non-Gaussian clusters (measured by the AD test), we show that the probability of being a non-Gaussian cluster correlates significantly with X-ray asymmetry but only shows a marginal correlation with centroid shift. These results confirm the shape of the radial velocity distribution as a useful proxy for cluster relaxation, which can then be applied to large redshift surveys lacking extensive X-ray coverage.

Espacios Sónicos: Intersecciones entre Arquitectura y Sonido

OpenAIRE

Goller, Beatrice

2014-01-01

En un mundo cada vez más poblado y complejo, el flujo de datos se incrementa a pasos gigantescos y la tecnología avanza en la profundización de temas cada día más concretos y específicos. A la vez, se ha entrado de lleno en la era digital, proporcionando infinitud de posibilidades de conectar campos de la ciencia, de la comunicación y del arte, que antes eran disciplinas independientes. Añadir la capa sonora en el ámbito arquitectónico intenta darle un significado más amplio al hecho de proye...

Las implicaciones de la era tecnológica en el Derecho Registral Civil costarricense

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Luis Bolaños Bolaños

2010-07-01

Full Text Available A partir de los conceptos y construcciones prácticas del Derecho Registral Civil, el artículo pretende, de la forma más práctica posible, dar a conocer el nuevo norte del Derecho Registral Civil en nuestro país, al describir los logros, esfuerzos y proyectos que el Tribunal Supremo de Elecciones ha desarrollado al incorporar las nuevas tecnologías en el registro de los hechos vitales. Pone especial interés en los cambios en los envíos de los datos registrales a la Institución y la forma de darles publicidad.

El cuerpo sensible - David Le Breton

OpenAIRE

Arcila Rojas, Claudia

2016-01-01

Como si la mano se deslizara por una superficie para darle vida al contacto amoroso de este vínculo; como si de esta caricia nacieran el color, la forma y el sonido; como si nacieran la sonrisa, la voz, la humedad y el beso; como si tocar significara grabar la intención de una creación al placer, a la satisfacción y al gusto; como si la práctica expresara la vivencia del maestro en el hacer imaginario donde se funde la obra de la enseñanza en el esfuerzo del artesano que nos asombra.

Lecciones de hermenéutica jurídica

OpenAIRE

Dueñas-Ruiz, Óscar-José

2006-01-01

Este libro contiene información y conceptos sobre hermenéutica jurídica. En él se tratan temas como la teoría de la interpretación; las orientaciones, reglas y principios que sirven en la práctica; la ideología como telón de fondo en las decisiones judiciales; la lógica como instrumento para la correcta interpretación; la importancia de un rompimiento del esquema formal y la búsqueda de la verdad para darle a la hermenéutica una razón histórica y social. Dentro de estos temas también se...

De un videojuego a las ecuaciones del tiro parabólico: una propuesta didáctica

OpenAIRE

Ruiz, Andrés; Oktaç, Asuman

2014-01-01

¿Es posible partir de un videojuego para enseñar matemáticas o física? En el presente diseño de actividades didácticas se parte precisamente del conocimiento intuitivo que puede generar en el alumno el uso del videojuego “AngryBirds”, para darle significado y aplicación a lo que en él acontece, y que en escenarios escolares se estudia como la “función de posición” o bien, las ecuaciones del tiro parabólico. Se presenta una propuesta didáctica para el estudio del tiro parabólico a partir de un...

Freudenthal es un arma cargada de futuro

OpenAIRE

Villarroya, Florencio

2000-01-01

Las matemáticas modernas han sido un slogan durante una década. Las matemáticas modernas, interpretadas literalmente matan la educación; interpretadas de acuerdo con su espíritu pueden darle vida. El autor sitúa las matemáticas en sus contextos, histórico, social y de desarrollo intelectual, y la educación matemática en el contexto de la educación en general, así como su desarrollo pasado y presente. En la cúspide de la producción científica, generalmente se reconoce que las matemáticas son un...

Amenazas actuales a la institucionalidad electoral en América Latina: La experiencia panameña

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Eduardo Valdés Escoffery

2017-07-01

Full Text Available Analiza la reforma constitucional de Panamá de 2004 y el conflicto de competencias que genera al darle a la Corte Suprema de Justica la facultad exclusiva para juzgar penalmente a los diputados, sin excepción por tipo de delito. Por tal motivo, juzgará también los delitos electorales y por ende de forma implícita tendrá la potestad de interpretar la normativa electoral; competencia privativa del Tribunal Electoral desde su creación en el año 1956, donde se le asigna la jurisdicción de interpretar, reglamentar y aplicar la ley electoral.

Media dalam Perspektif Masyarakat Tontonan “Jokowi Spectacle”

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Sukma Ari Ragil Putri

2016-03-01

Full Text Available In this era, celebrities are shaped and disseminated by the media. Media generates celebrities. When someone become the most popular person in the news then he/she would instantly become a celebrity. One of the figures that always make an interesting spectacle is Jokowi. As a presidential candidate of PDI Perjuangan, Jokowi have all aspects to be an interesting spectacle because of his construction of self-image that is different from the self-image of other president in Indonesia. As a media darling, Jokowi makes a Jokowi Spectacle. It becomes much more interesting when Jokowi Spectacle is compared with its successor, Obama Spectacle.

Juan Valdez la estrategia detrás de la marca

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Ana María Parente

2017-10-01

Full Text Available El libro Juan Valdez, la estrategia detrás de la marca busca explicar la táctica de valorización del café colombiano desarrollada por la Federación Nacional de Cafeteros (FNC, que tiene como principal objetivo beneficiar a los caficultores colombianos a lo largo de la cadena de valor. Para ello, el texto hace un recuento del contexto del mercado cafetero mundial, haciendo énfasis en los principales proveedores y consumidores hasta finalmente centrarse en la construcción de la marca Café de Colombia® y Juan Valdez® como estrategias para darle competitividad al grano colombiano.

Anti-Ageing Cultures, Biopolitics and Globalisation

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Brett Neilson

2011-11-01

Full Text Available In March 2004, the author attended the Inaugural International Conference on Longevity at the Sydney Exhibition and Convention Centre in Darling Harbour. As a cultural researcher interested in the interactions between demographic shifts, capitalist globalisation and changing forms of political power, the prospect of a direct encounter with the debates and practices surrounding the burgeoning field of anti-ageing medicine promised a means to observe the complex cultural dynamics of population ageing at play. This article explores the discord the atuhor witnessed; a quarrel that, despite the march of technological advance, attests the ongoing conflict in the nexus where politics meets life.

Categorization of States Beyond Strong and Weak

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Peter Tikuisis

2017-09-01

Full Text Available The discourse on poor state performers has suffered from widely varying definitions on what distinguishes certain weak states from others. Indices that rank states from strong to weak conceal important distinctions that can adversely affect intervention policy. This deficiency is addressed by grouping states according to their performance on three dimensions of statehood: authority, legitimacy, and capacity. The resultant categorization identifies brittle states that are susceptible to regime change, impoverished states often considered as aid darlings, and fragile states that experience disproportionately high levels of violent internal conflict. It also provides a quantifiable means to analyze transitions from one state type to another for more insightful intervention policy.

Protección contra inundaciones en zonas urbanas: Caso de la urbanización San Diego distrito de San Martín de Porres-Lima

OpenAIRE

Orosco Benites, Juan Carlos Felipe; Orosco Benites, Juan Carlos Felipe

2004-01-01

El presente trabajo de investigación, trate de explicar en forma didáctica los conocimientos necesarios para poder hacer un análisis y diseño de una protección contra inundaciones en zonas urbanas. En este caso se tomará como ejemplo la urbanización San Diego, en el distrito de San Martín de Porres, el cual periódicamente sufre graves peligros en los meses de enero a marzo por las crecidas del río Chillón. Por tal motivo, se buscó darle una solución técnica a este problema, por...

Granulomatous dermatitis due to Malassezia sympodialis.

Science.gov (United States)

Desai, Harsha B; Perkins, Philip L; Procop, Gary W

2011-09-01

A 67-year-old man, with multiple skin lesions that appeared over 2 years, had biopsies that disclosed granulomatous dermatitis with associated small yeasts. The urinary antigen test results were negative for Histoplasma infection; cultures from the biopsies did not grow any fungi or other potential pathogens. The chest roentgenogram results were normal. Morphologic examination revealed features of a Malassezia species. Broad-range fungal polymerase chain reaction and DNA sequencing disclosed that the infecting fungus was Malassezia sympodialis , a lipid-dependent yeast. This report supports one other case report that Malassezia species may cause granulomatous dermatitis; in the previous case, the etiologic agent was Malassezia pachydermatis , a nonlipid-dependent species. We recommend the use of lipid-supplemented culture media for specimens from patients with granulomatous dermatitis because several Malassezia species are dependent on lipid; the absence of lipid supplementation in routine cultures likely explains the negative culture results for this patient. This, to our knowledge, is the first report of granulomatous dermatitis caused by M sympodialis.

Microepidemia de histoplasmose na zona rural de Brasília - DF - 1967: II - Estudos Epidemiológico e Parasitológico da Fonte de Infecção

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Sydney Schmidt

1973-04-01

Full Text Available Neste trabalho são relatadas pesquisas parasitológicas e epiâemiológicas realizadas numa provável fonte de infecção de Histoplasmose da área rural do D. F. - Brasília, onde 14 pessoas contraíram a doença. Os estudos clínico, imunológico e radiológico foram anteriormente descritos. Os autores conseguiram isolar o H. capsulatum do solo da caverna e das vísceras e do sangue de morcegos (Phyllostomus hastatus hastatus, Pallas 1767 que nela habitavam. Resultaram negativas as tentativas de isolamento do fungo de animais sentinelas (cobaios, assim como não se obteve neles a viragem dos testes intradérmicos com histoplasmina. Em impressões de vísceras dos morcegos, constataram-se formas semelhantes as do T. gondii que posteriormente foram isoladas, em camundongos jovens, por inoculação de vísceras maceradas e sangue. Foram encontrados 2 ectoparasitos nos morcegos: Boophilus microplus e um díptero da família Streblidae. O ácaro albergava tripomastigotos do tipo cruzi, não sendo porém conseguido seu isolamento. No tubo digestivo dos quirópteros, foram retirados nematódeos (Histiostrongylus octaeantus e cestódeos do gênero Mathevotaenia. Foram capturados, em torno da entrada da caverna, 2 exemplares de Cercomys cunicularis apereoide não sendo examinados sob o ponto de vista parasitológico. Testes intradérmicos realizados em 826 habitantes da área resultaram positivos em 184 (22,27%. A gruta, fonte da infecção, está localizada em uma formação calcárea, pertencente à série Bambuí, acreditando-se, pelos aspectos tectônicos, ser da idade siluriana. No Brasil, o isolamento de H. capsulatum de solo, guanos de morcegos e vísceras de roedores já tinham sido realizados; contudo, esta foi a primeira vez que se conseguiu isolá-lo do solo de uma caverna, fonte de infecção, e das vísceras e sangue de morcegos. Os resultados obtidos com os testes intradérmicos com histoplasmina demonstraram a prevalência de

Influence of approach velocity and mesh size on the entrainment and contact of a lowland river fish assemblage at a screened irrigation pump.

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Craig A Boys

Full Text Available Fish screens can help prevent the entrainment or injury of fish at irrigation diversions, but only when designed appropriately. Design criteria cannot simply be transferred between sites or pump systems and need to be developed using an evidence-based approach with the needs of local species in mind. Laboratory testing is typically used to quantify fish responses at intake screens, but often limits the number of species that can studied and creates artificial conditions not directly applicable to screens in the wild. In this study a field-based approach was used to assess the appropriateness of different screen design attributes for the protection of a lowland river fish assemblage at an experimental irrigation pump. Direct netting of entrained fish was used along with sonar technology to quantify the probability of screen contact for a Murray-Darling Basin (Australia fish species. Two approach velocities (0.1 and 0.5 m.sec(-1 and different sizes of woven mesh (5, 10 and 20 mm were evaluated. Smaller fish (<150 mm in the assemblage were significantly more susceptible to entrainment and screen contact, especially at higher approach velocities. Mesh size appeared to have little impact on screen contact and entrainment, suggesting that approach velocity rather than mesh size is likely to be the primary consideration when developing screens. Until the effects of screen contacts on injury and survival of these species are better understood, it is recommended that approach velocities not exceed 0.1 m.sec(-1 when the desire is to protect the largest range of species and size classes for lowland river fish assemblages in the Murray-Darling Basin. The field method tested proved to be a useful approach that could compliment laboratory studies to refine fish screen design and facilitate field validation.

Empirical Power Comparison Of Goodness of Fit Tests for Normality In The Presence of Outliers

International Nuclear Information System (INIS)

Saculinggan, Mayette; Balase, Emily Amor

2013-01-01

Most statistical tests such as t-tests, linear regression analysis and Analysis of Variance (ANOVA) require the normality assumptions. When the normality assumption is violated, interpretation and inferences may not be reliable. Therefore it is important to assess such assumption before using any appropriate statistical test. One of the commonly used procedures in determining whether a random sample of size n comes from a normal population are the goodness-of-fit tests for normality. Several studies have already been conducted on the comparison of the different goodness-of-fit(see, for example [2]) but it is generally limited to the sample size or to the number of GOF tests being compared(see, for example [2] [5] [6] [7] [8]). This paper compares the power of six formal tests of normality: Kolmogorov-Smirnov test (see [3]), Anderson-Darling test, Shapiro-Wilk test, Lilliefors test, Chi-Square test (see [1]) and D'Agostino-Pearson test. Small, moderate and large sample sizes and various contamination levels were used to obtain the power of each test via Monte Carlo simulation. Ten thousand samples of each sample size and contamination level at a fixed type I error rate α were generated from the given alternative distribution. The power of each test was then obtained by comparing the normality test statistics with the respective critical values. Results show that the power of all six tests is low for small sample size(see, for example [2]). But for n = 20, the Shapiro-Wilk test and Anderson – Darling test have achieved high power. For n = 60, Shapiro-Wilk test and Liliefors test are most powerful. For large sample size, Shapiro-Wilk test is most powerful (see, for example [5]). However, the test that achieves the highest power under all conditions for large sample size is D'Agostino-Pearson test (see, for example [9]).

A latitudinal study of oxygen isotopes within horsehair

Science.gov (United States)

Thompson, E.; Bronk Ramsey, C.; McConnell, J. R.

2016-12-01

This study aims to explore the hypothesis that 'if oxygen isotope ratios deplete with decreasing temperature then a study of oxygen isotope ratios within horsehair from Oxfordshire to Iceland will show a latitudinal depletion gradient'. By looking at oxygen isotope values at different geographical positions, we can track the relationship with latitude and with different regional climate features. This will provide a firmer understanding of how to compare climate records from different locations. Additionally, a comparison of the horse breeds from this study to those analysed within previous studies will create an even better understanding of the intra-species variation within the δ18O values of horsehair. A total of 24 horses were sampled on the 7th March from Thordale Stud in Shetland, the Icelandic Food And Veterinary Authority in Iceland, the Exmoor Pony Centre in Exmoor and the Pigeon House Equestrian Centre in Oxfordshire. By starting the sampling process from the most recent growth at the follicle, the sampling date becomes a chronological marker, temporally fixing the first sample within a sequential set of data points extending for one year or longer, depending on the length of each individual hair. The samples were analysed for oxygen isotope values using an IRMS coupled within a Sercon HTEA. Preliminary results show a latitudinal gradient is evident on comparison between the locations, consistent with the findings of Darling and Talbot's study of fresh water isotopes in the British Isles (2003). These results support the hypothesis, showing that a study of oxygen isotope ratios within horse hair from Oxfordshire to Iceland showing a latitudinal depletion gradient, consistent with a depletion of oxygen isotope ratios due to decreasing temperatures. Darling, W. and Talbot, J. (2003). The O and H stable isotope composition of freshwaters in the British Isles. 1. Rainfall. Hydrol. Earth System Science, 7(2), pp.163-181.

Propuestas para el Plan Nacional de Salud y Medio Ambiente

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José María Ordóñez Iriarte

2008-12-01

Full Text Available De acuerdo con las estrategias internacionales en materia de salud y medio ambiente, los Ministerios de Sanidad y de Medio Ambiente pusieron en marcha en 2007 los mecanismos necesarios para la elaboración del Plan Nacional de Salud y Medio Ambiente. El primer paso ha sido la firma de un acuerdo de encomienda de gestión con el Instituto de Salud Carlos III para que éste diseñara las bases sobre las que sustentar el plan. El comité científico creado al efecto ha redactado un informe de bases para lo que ha contado con el concurso de un nutrido grupo de expertos. Las propuestas que se recogen en el informe constituyen el contenido del presente trabajo. Las propuestas hacen referencia a los ítems considerados prioritarios en la Estrategia Europea de Medio Ambiente y Salud, es decir, cáncer, alteraciones endocrinas, trastornos del desarrollo neurológico y enfermedades respiratorias, y se organizan en torno a los principales factores de riesgo ambiental para la salud: agua, compuestos químicos tóxicos persistentes, campos electromagnéticos, radicaciones ionizantes, ruido y cambio climático y temperaturas extremas. Para dar consistencia al plan se señalan algunas medidas imprescindibles que aseguren su viabilidad administrativa, política, técnica y financiera. Para darle coherencia, se arbitran unas líneas prioritarias comunes y unas estrategias metodológicas compatibles. Para darle forma, se señalan los programas nacionales que deberán implementarse y que deberán basarse en esa consistencia y coherencia. Más que entrar a concretar lo que se debe hacer —materia propia del futuro plan—, el informe señala cómo se debe hacer para lograr resultados exitosos.

Using a Population Model to Inform the Management of River Flows and Invasive Carp ( Cyprinus carpio)

Science.gov (United States)

Koehn, John D.; Todd, Charles R.; Zampatti, Brenton P.; Stuart, Ivor G.; Conallin, Anthony; Thwaites, Leigh; Ye, Qifeng

2018-03-01

Carp are a highly successful invasive fish species, now widespread, abundant and considered a pest in south-eastern Australia. To date, most management effort has been directed at reducing abundances of adult fish, with little consideration of population growth through reproduction. Environmental water allocations are now an important option for the rehabilitation of aquatic ecosystems, particularly in the Murray-Darling Basin. As carp respond to flows, there is concern that environmental watering may cause floodplain inundation and provide access to spawning habitats subsequently causing unwanted population increase. This is a management conundrum that needs to be carefully considered within the context of contemporary river flow management (natural, environmental, irrigation). This paper uses a population model to investigate flow-related carp population dynamics for three case studies in the Murray-Darling Basin: (1) river and terminal lakes; (2) wetlands and floodplain lakes; and (3) complex river channel and floodplain system. Results highlight distinctive outcomes depending on site characteristics. In particular, the terminal lakes maintain a significant source carp population regardless of river flow; hence any additional within-channel environmental flows are likely to have little impact on carp populations. In contrast, large-scale removal of carp from the lakes may be beneficial, especially in times of extended low river flows. Case studies 2 and 3 show how wetlands, floodplain lakes and the floodplain itself can now often be inundated for several months over the carp spawning season by high volume flows provided for irrigation or water transfers. Such inundations can be a major driver of carp populations, compared to within channel flows that have relatively little effecton recruitment. The use of a population model that incorporates river flows and different habitats for this flow-responsive species, allows for the comparison of likely population

Lo fantástico y la memoria histórica en Rivas

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Frauke Bode

2015-07-01

Full Text Available A partir de tres ejemplos, En salvaje compañía (1994, El lápiz del carpintero (1998 y Los libros arden mal (2006, esta contribución pretende determinar la función de ‘lo fantástico’ en las novelas de Ma-nuel Rivas, con respecto a la memoria cultural de un evento traumático como la Guerra Civil y el fran-quismo. La argumentación parte de la hipótesis de que lo ‘real maravilloso gallego’ ofrece una estruc-tura particularmente apta para hablar de la Guerra Civil al darles a los muertos un espació ficticio de acción

Vivienda Social y Violencia Intrafamiliar: Una Relación Inquietante. ¿Una Política Social que Genera Nuevos Problemas Sociales?

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Ana Sugranyes

2005-01-01

Full Text Available El artículo hace presente que la producción de viviendas de laactual política de Estado ha permanecido con un bajo perfil deinnovación, llegando a una situación que amerita conurgencia un mejoramiento radical. Ello ocurre por lapermanencia de formas de licitación de construcciones,postulaciones, asignaciones, etc., donde las características delos agentes participantes permanecen estratificadas, dando lasensación de que todo marcha bien y en perfecto orden. Acontrapunto de lo anterior, se hacen ver los impactos socialesnegativos atribuibles a la calidad del hábitat producido, lo quereafirma la necesidad de darle un vuelco renovador a lapolítica habitacional estatal.

Mesa solución política al conflicto armado Oslo y la Habana 2: la imaginación pacificadora

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Humberto Vélez R

2012-01-01

Full Text Available El presente texto realizado en razón del I Congreso regional de paz – Antioquia, se realiza una recopilación investigativa respecto de los temas tocados en la agenda de paz entre el gobierno y la guerrilla y sus posibles consecuencias, para ello se toman las diferentes publicaciones realizadas en el blog Atisbos, desarrollado por el autor y tomando como referencia el número 158, y la expectativa generada por los resultados del proceso Santos-Guerrillas, con el fin de darle un marco conceptual analítico adecuado al proceso de Oslo y de la Habana 2, y para lo cual se realiza en lenguaje crítico-político.

Distribution functions for the linear region of the S-N curve

Energy Technology Data Exchange (ETDEWEB)

Mueller, Christian; Waechter, Michael; Masendorf, Rainer; Esderts, Alfons [TU Clausthal, Clausthal-Zellerfeld (Germany). Inst. for Plant Engineering and Fatigue Analysis

2017-08-01

This study establishes a database containing the results of fatigue tests from the linear region of the S-N curve using sources from the literature. Each set of test results originates from testing metallic components on a single load level. Eighty-nine test series with sample sizes of 14 ≤ n ≤ 500 are included in the database, resulting in a sum of 6,086 individual test results. The test series are tested in terms of the type of distribution function (log-normal or 2-parameter Weibull) using the Shapiro-Wilk test, the Anderson-Darling test and probability plots. The majority of the tested individual test results follows a log-normal distribution.

Simón Rodríguez, la Constitución de 1826 y el Proyecto de Educación Popular

OpenAIRE

GUÁNCHEZ DE MÉNDEZ, Zenaida

2005-01-01

En este trabajo se busca dilucidar, por una parte, la relación entre el proceso de conformación de la «ciudadanía política» indispensable para el ejercicio de la «soberanía», en el marco del establecimiento de la nueva Nación o en todo caso, de la nueva República de Bolivia y el necesario proceso de «aprendizaje político» o «socialización política» (proceso educativo) que permitiría darle existencia real a ese «ciudadano ideal» definido por la Constitución Boliviana de 1826. Y por la otra, la...

Límites para el concepto de desplazamiento forzado intraurbano. El papel de la acción de tutela y de la jurisprudencia en su construcción

OpenAIRE

Atehortúa Arredondo, Clara Inés

2009-01-01

La construcción del concepto de desplazamiento forzado intraurbano ha sido un problema no sólo de tipo teórico sino de política pública, y como tal su definición y limitación más que hacerse en los escenarios políticos se ha hecho en la esfera judicial, a través de la acción de tutela. Los desplazamientos masivos en Medellín han sido fuente para la discusión sobre el concepto, en especial para la discusión de los elementos que lo conforman. Este escrito se dirige a darle una lectura a las sen...

From sex strangler to model citizen: Mexico's most famous murderer and the defeat of the death penalty.

Science.gov (United States)

Meade, Everard

2010-01-01

Gregorio Cárdenas Hernández was Mexico's most infamous serial killer. After he confessed to killing four young women and burying them behind his home, he became the darling of the crime pages and criminological experts alike, and his case provoked a lively debate over the reinstatement of the death penalty in congress. The following essay uses his story, the policy debates it provoked, and his broader institutional odyssey in La Castañeda mental asylum (1943–1947) and Lecumberri prison (1948–1976) to explore how issues that affected Mexicans across the social spectrum were discussed and settled in a political system that was neither a dictatorship nor a democracy.

Using mental-modelling to explore how irrigators in the Murray–Darling Basin make water-use decisions

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Ellen M. Douglas

2016-06-01

New hydrological insights for the region: Results suggest support for greater local and irrigator involvement in water management decisions. Many, if not most, of the irrigators understood the need for, or at least the inevitability of, governmental policies and regulations. However, a lack of accountability, predictability, and transparency has added to the uncertainty in farm-based water decision-making. Irrigators supported the concept of environmental sustainability, although they might not always agree with how the concept is implemented. The mental modelling approach facilitated knowledge sharing among stakeholders and can be used to identify common goals. Future research utilizing the mental modelling approach may encourage co-management and knowledge partnerships between irrigators, water managers and government officials.

Environmental flows and water quality objectives for the River Murray.

Science.gov (United States)

Gippel, C; Jacobs, T; McLeod, T

2002-01-01

Over the past decade, there intense consideration of managing flows in the River Murray to provide environmental benefits. In 1990 the Murray-Darling Basin Ministerial Council adopted a water quality policy: To maintain and, where necessary, improve existing water quality in the rivers of the Murray-Darling Basin for all beneficial uses - agricultural, environmental, urban, industrial and recreational, and in 1994 a flow policy: To maintain and where necessary improve existing flow regimes in the waterways of the Murray-Darling Basin to protect and enhance the riverine environment. The Audit of Water Use followed in 1995, culminating in the decision of the Ministerial Council to implement an interim cap on new diversions for consumptive use (the "Cap") in a bid to halt declining river health. In March 1999 the Environmental Flows and Water Quality Objectives for the River Murray Project (the Project) was set up, primarily to establish be developed that aims to achieve a sustainable river environment and water quality, in accordance with community needs, and including an adaptive approach to management and operation of the River. It will lead to objectives for water quality and environmental flows that are feasible, appropriate, have the support of the scientific, management and stakeholder communities, and carry acceptable levels of risk. This paper describes four key aspects of the process being undertaken to determine the objectives, and design the flow options that will meet those objectives: establishment of an appropriate technical, advisory and administrative framework; establishing clear evidence for regulation impacts; undergoing assessment of environmental flow needs; and filling knowledge gaps. A review of the impacts of flow regulation on the health of the River Murray revealed evidence for decline, but the case for flow regulation as the main cause is circumstantial or uncertain. This is to be expected, because the decline of the River Murray results

Incidence and Control of Selakarang Disease In Horses

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Riza Zainuddin Ahmad

2012-06-01

Full Text Available Selakarang is a fungal disease attacking horses. Although the mortality rate is low, the morbidity is high leading to economic loss. The island of Sulawesi has about 151.000 horses and they are distributed in 5 provinces: North, Central, West, South, and South-East Sulawesi which potentially has endemic outbreaks caused by the Selakarang fungus, Histoplasma farciminosum. The disease might be endemic throughout Indonesia if the horse trading is not monitored. In Maros, South Sulawesi, the disease is found with symptoms in the form of nasal, cutan, and ocular symptoms. Ignorance of the appropriate authorities will increase the likelihood of spread of the disease. According to the Staatblad act produced in 1912 and the disease belonged to the zoonotic disease and when it is not well handled and properly managed, infection to human may occur. Prevention is better than treatment. In the future, we may propose to produce inactive vaccines and develop serological test to detect antigen and antibody in RIVS collaborating with other government agencies or private parties interested in this disease control.

TERRITÓRIOS, PAISAGENS E REPRESENTAÇÕES: um diálogo em construção

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Maria Geralda de Almeida

2011-01-01

Full Text Available Las conceptiones de territorio y paisajes, para los geógrafos de la abordagen cultural, son de un punto de vista en que la humanidad debe impregnar a "leer" el espacio, es decir, considerar cómo los hombres crean los territorios y paisajes de cómo atribuen un signifi cado y darles un sentido. Para los geógrafos, es comprender que en el espacio la materialidad tangible está bañada de elementos imateriales e intangibles. En este artículo tratamos de refl exionar sobre esa dimensión humana, por la abordagen de la geografi a cultural con el enfoque en los territorios culturales, en las paisajes culturales y en la cartografía.

¡SALUD, MINSALUD!

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Fernando Sánchez Torres

2012-01-01

Full Text Available Desde 1946, el Estado delegó en una agencia suya la responsabilidad directa de atender lo relacionado con la salud de los colombianos. Esa agencia nació con la categoría de Ministerio y al frente suyo se designó un funcionario con la investidura de ministro. Durante el gobierno del presidente Uribe, con ánimo de reducir la burocracia, se hizo un osado ensayo: fundir en uno de los ministerios de Trabajo y de Salud y encargar de él a un ministro bicéfalo. Los resultados no fueron afortunados, a tal punto que su sucesor, Juan Manuel Santos, decidió escindirlo y volver a lo que había, con miras a darles mayor solvencia a los dos sectores.

Redistribution of caesium-137 by erosion and deposition on an australian soil

International Nuclear Information System (INIS)

McCallan, M.E.; Rose, C.W.; O'Leary, B.M.

1980-01-01

Caesium-137, a nuclear fallout product which is carried down to the ground by rainfall and becomes tightly adsorbed to soil particles, is being used to study soil erosion and accumulation. The measurement of 137 Cs activity in soil cores in an upland catchment on the Darling Downs has revealed a vertical and areal distribution of this isotope which is in general agreement with expectations based on the topography, the observed erosion and deposition sites, the variation in 137 Cs fallout through time, and hypotheses of 137 Cs redistribution. Such information may allow the development of a practical technique for estimating soil erosion and accumulation rates using this isotope; it also allows testing of mathematical models of erosion/deposition processes

THE ECONOMIC AND PSYCHO-SOCIAL EXPERIENCES AND COPING RESOURCES OF FAMILY MEMBERS CARING FOR PEOPLE LIVING WITH AIDS IN THEIR HOMES IN BHAMBAYI, KWAZULU-NATAL, SOUTH AFRICA

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Raniga, Tanusha

2013-05-01

Full Text Available There is empirical evidence that families have responded with much resilience and compassion to caring for persons living with AIDS (PWAs in their homes (Engelbrecht & Kasiram, 2007; Sekokotla & Mturi, 2004; Simpson & Raniga, 2004. At the same time families in poverty-stricken communities are increasingly struggling and failing to provide optimally for the economic and psycho-social needs of PWAs who are in their care (Bartlett & Finkbeiner, 2006; Darling, Olmstead & Tiggleman, 2009. It is not surprising, however, at a time when the devastating effects of HIV and AIDS are all too evident, that international organisations, national governments and civil society organisations recognise the invaluable role played by extended family members as support caregivers in the care of those terminally ill with AIDS.

La precarización del trabajo desde una perspectiva sociocultural en un contexto fronterizo

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Marlene Solís

2014-01-01

Full Text Available En este artículo se analiza la conformación del mercado de trabajo de la industria del vestido en Tijuana; se identifican los factores estructurales generadores de precariedad y, según las vivencias respecto a ella, se reconstruyen perfiles distintos de los y las trabajadoras. El objetivo de esta propuesta analítica es mostrar la manera en que se entrelazan las escalas micro, meso y macrosocial reproduciendo o produciendo las condiciones de precariedad que prevalecen en los empleos de la industria de la confección en Tijuana. Para interpretar la experiencia de la precariedad, se aborda su dimensión sociocultural, al darle un papel central a los significados que le otorgan las personas al trabajo.

A Statistical Toolkit for Data Analysis

International Nuclear Information System (INIS)

Donadio, S.; Guatelli, S.; Mascialino, B.; Pfeiffer, A.; Pia, M.G.; Ribon, A.; Viarengo, P.

2006-01-01

The present project aims to develop an open-source and object-oriented software Toolkit for statistical data analysis. Its statistical testing component contains a variety of Goodness-of-Fit tests, from Chi-squared to Kolmogorov-Smirnov, to less known, but generally much more powerful tests such as Anderson-Darling, Goodman, Fisz-Cramer-von Mises, Kuiper, Tiku. Thanks to the component-based design and the usage of the standard abstract interfaces for data analysis, this tool can be used by other data analysis systems or integrated in experimental software frameworks. This Toolkit has been released and is downloadable from the web. In this paper we describe the statistical details of the algorithms, the computational features of the Toolkit and describe the code validation

L'aile dite « des prélats » au château de Grignan (Drôme 1684-1689

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Christian Trézin

2012-04-01

Full Text Available La construction de l'aile « des prélats » au château de Grignan de 1684 à 1689 correspond à la requalification d'un secteur composite constitué du XIIe au XVIIe siècle. Commanditée sans intervention d'architecte par l'évêque de Carcassonne et l'archevêque d'Arles, frères du comte de Grignan, elle est bâtie en deux chantiers successifs selon des partis distincts dont l'harmonisation laborieuse est restée inachevée. Si le bâtiment de Carcassonne reflète initialement le savoir traditionnel de l'entrepreneur Florent Loiseleur, celui d'Arles est imprégné des œuvres récentes de l'agence de Jules Hardouin-Mansart dont le maçon Jacque Jaquet dit Beaufleury a probablement été tenu de s'inspirer. Ce chantier est un exemple du mode d'action des architectes amateurs dans le milieu conservateur de la noblesse provençale.The "prelates" wing of the castle of Grignan was built from 1684 to 1689. It was supposed to be a requalification and a renewal of a heterogeneous area erected between 12th to 17th century. Sponsored by the bishop of Carcassonne and the archbishop of Arles, brothers of the count of Grignan, no architect was involved in its design. It was built in two successive phases reflecting distinct conceptions and accordingly its architctural harmonization was made difficult and remained unfulfilled. If the Carcassonne building reflects the traditional savoir faire of the building contractor Florent Loiseleur, Arles's was deeply close to the recent works of Jules Hardouin-Mansart's agency whom the master builder Jacque Jaquet, said Beaufleury, had most probably to be inspired of. This construction is an example of the way amateur architects used to work in the conservative circle of provençal nobility.

SISTEMA DE FALLAS DE CALIDAD: ESTUDIO DE CASO CON UN ENFOQUE DE GESTIÓN DEL CONOCIMIENTO

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Gerardo Sánchez Schmitz

2004-03-01

Full Text Available

El presente estudio de caso se desarrolló en el Departamento de Calidad en una de las empresas comercializadoras de carne más importantes de México, ubicada en Hermosillo, Sonora, al noroeste de México. El objetivo de este trabajo es presentar la solución a un problema de manejo de información de fallas de calidad documentadas en el Departamento de Control de Calidad, utilizando el enfoque de gestión del conocimiento mediante el desarrollo de una memoria organizacional, para darle una solución más rápida a las reclamaciones de los clientes (internos y externos.

Does high-stakes testing increase cultural capital among low-income and racial minority students?

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Won-Pyo Hong

2008-03-01

Full Text Available This article draws on research from Texas and Chicago to examine whether high-stakes testing enables low-income and racial minority students to acquire cultural capital. While students' performance on state or district tests rose after the implementation of high-stakes testing and accountability policies in Texas and Chicago in the 1990s, several studies indicate that these policies seemed to have had deleterious effects on curriculum, instruction, the percentage of students excluded from the tests, and student dropout rates. As a result, the policies seemed to have had mixed effects on students' opportunities to acquire embodied and institutionalized cultural capital. These findings are consistent with the work of Shepard (2000, Darling-Hammond (2004a, and others who have written of the likely negative repercussions of high-stakes testing and accountability policies.

Infancias Ignoradas. Hijos e Hijas de Mujeres Víctimas de Violencia en situación de Refugio

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Rosalia Carrillo Meráz

2018-04-01

Full Text Available En México, en la década de 1990 se crean los primeros refugios para mujeres víctimas de violencia con el fin de atenderlas y darles un lugar donde vivir al momento de huir de su agresor. Se diseñaron estrategias para atenderlas de manera integral pero, en un inicio no se pensó en sus hijos e hijas, quienes llegaban con ellas al refugio y sólo se les entretenía mientras psicólogas y trabajadoras sociales atendían a sus madres. Ahora, ante la necesidad de proteger a la comunidad infantil en situación de refugio, empiezan a diseñarse estrategias para dar seguimiento y atención a estos menores que antes eran ignorados como víctimas.

Emprendimiento social, una mirada a la equidad

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Ignacio Barrios Parejo

2017-07-01

Full Text Available Este artículo comprende una revisión teórica acerca del emprendimiento social, entendido como una iniciativa de negocio con o sin fin de lucro, cuyo objetivo es la generación de valor social. Siendo este un campo de investigación reciente y atractivo, el objetivo de esta revisión consiste a su vez en identificar y generar una transformación social real, a partir de la reducción de los índices de pobreza, de la percepción de injusticia entre los ciudadanos y del aumento de la capacidad del país para darle a cada uno de sus ciudadanos lo que se merece en función de sus méritos y condiciones.

Global monthly water scarcity: blue water footprints versus blue water availability.

Science.gov (United States)

Hoekstra, Arjen Y; Mekonnen, Mesfin M; Chapagain, Ashok K; Mathews, Ruth E; Richter, Brian D

2012-01-01

Freshwater scarcity is a growing concern, placing considerable importance on the accuracy of indicators used to characterize and map water scarcity worldwide. We improve upon past efforts by using estimates of blue water footprints (consumptive use of ground- and surface water flows) rather than water withdrawals, accounting for the flows needed to sustain critical ecological functions and by considering monthly rather than annual values. We analyzed 405 river basins for the period 1996-2005. In 201 basins with 2.67 billion inhabitants there was severe water scarcity during at least one month of the year. The ecological and economic consequences of increasing degrees of water scarcity--as evidenced by the Rio Grande (Rio Bravo), Indus, and Murray-Darling River Basins--can include complete desiccation during dry seasons, decimation of aquatic biodiversity, and substantial economic disruption.

Exporeciclaje 2015. Estrategia de educación ambiental

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César Morales

2016-01-01

Full Text Available La educación ambiental se facilita por el uso de actividades vivenciales (González, 2012. Esta investigación del tipo sistematización de experiencias (Martinic, 1984 tiene como finalidad la reflexión de los aprendizajes derivados de la actividad “exporeciclaje 2015”. El propósito de esta fue favorecer la formación de una consciencia ecológica en la escuela y disminuir la contaminación usando el reciclaje. Se instalaron 8 stands donde se dictaron charlas sobre la problemática en cuestión. La interacción indica que los estudiantes reconocieron la importancia del aprovechamiento de residuos con la finalidad de darle un mayor tiempo de vida útil, contribuyendo con el uso racional del ambiente.

Conclusiones adoptadas por la primera convención venerológica reunida en Medellín en abril de 1935

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Gustavo Uribe Escobar

1935-05-01

Full Text Available Unificación de los sistemas en los centros de tratamiento, con el fin de darles a todos la misma organización científica. Enfermeras sociales. Fomento de la creación de centros venerológicos en las poblaciones. Problema de la prostitución. Estudiar las medidas más convenientes al respecto. ¿prohibición? ¿abolición? ¿reglamentación de los lenocinios? campaña educativa popular. Comprende la educación del niño, del adolescente y del adulto en materia sexual, moral y antivenérea. Legislación venérea. Campaña educativa popular. Delito de contaminación. Tratamiento obligatorio. Certificado previo para colocarse en empresas particulares u oficiales.

Control Servo-Visual de un Robot Manipulador Planar Basado en Pasividad

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Carlos Soria

2008-10-01

Full Text Available Resumen: En este trabajo se diseña un controlador servo visual basado en la propiedad de pasividad del sistema visual. Se propone un regulador con ganancias de control variables, de tal manera que se evita la saturación de los actuadores y al mismo tiempo presenta la capacidad de corregir errores de pequeña magnitud. Asimismo el diseno se hace tenieñdo en cuenta el desempeño L2, a fin de darle capacidad de seguimiento de objetos en movimiento, con un error de control pequeño. Se muestran resultados experimentales realizados en un robot manipulador industrial tipo planar para verificar el cumplimiento de los objetivos del controlador propuesto. Palabras Clave: robot manipulador industrial, control servo visual, control no lineal, pasividad

Biocontrol of Phytophthora Blight and Anthracnose in Pepper by Sequentially Selected Antagonistic Rhizobacteria against Phytophthora capsici.

Science.gov (United States)

Sang, Mee Kyung; Shrestha, Anupama; Kim, Du-Yeon; Park, Kyungseok; Pak, Chun Ho; Kim, Ki Deok

2013-06-01

We previously developed a sequential screening procedure to select antagonistic bacterial strains against Phytophthora capsici in pepper plants. In this study, we used a modified screening procedure to select effective biocontrol strains against P. capsici; we evaluated the effect of selected strains on Phytophthora blight and anthracnose occurrence and fruit yield in pepper plants under field and plastic house conditions from 2007 to 2009. We selected four potential biocontrol strains (Pseudomonas otitidis YJR27, P. putida YJR92, Tsukamurella tyrosinosolvens YJR102, and Novosphingobium capsulatum YJR107) among 239 bacterial strains. In the 3-year field tests, all the selected strains significantly (P anthracnose incidence in at least one of the test years, but their biocontrol activities were variable. In addition, strains YJR27, YJR92, and YJR102, in certain harvests, increased pepper fruit numbers in field tests and red fruit weights in plastic house tests. Taken together, these results indicate that the screening procedure is rapid and reliable for the selection of potential biocontrol strains against P. capsici in pepper plants. In addition, these selected strains exhibited biocontrol activities against anthracnose, and some of the strains showed plant growth-promotion activities on pepper fruit.

Isolation and characterization of novel chitinolytic bacteria

Science.gov (United States)

Gürkök, Sümeyra; Görmez, Arzu

2016-04-01

Chitin, a linear polymer of β-1,4-N-acetylglucosamine units, is one of the most abundant biopolymers widely distributed in the marine and terrestrial environments. It is found as a structural component of insects, crustaceans and the cell walls of fungi. Chitinases, the enzymes degrading chitin by cleaving the β-(1-4) bond, have gained increased attention due to their wide range of biotechnological applications, especially for biocontrol of harmful insects and phytopathogenic fungi in agriculture. In the present study, 200 bacterial isolates from Western Anatolia Region of Turkey were screened for chitinolytic activity on agar media amended with colloidal chitin. Based on the chitin hydrolysis zone, 13 isolates were selected for further study. Bacterial isolates with the highest chitinase activity were identified as Acinetobacter calcoaceticus, Arthrobacter oxydans, Bacillus cereus, Bacillus megaterium, Brevibacillus reuszeri, Kocuria erythromyxa, Kocuria rosea, Novosphingobium capsulatum, Rhodococcus bratislaviensis, Rhodococcus fascians and Staphylococcus cohnii by MIS and BIOLOG systems. The next aims of the study are to compare the productivity of these bacteria quantitatively, to purify the enzyme from the most potent producer and to apply the pure enzyme for the fight against the phytopathogenic fungi and harmful insects.

CT scan findings of fungal pneumonia; Diagnose der Pilzpneumonie in der Thorax-CT

Energy Technology Data Exchange (ETDEWEB)

Heckmann, M.; Uder, M.; Bautz, W.; Heinrich, M. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Diagnostische Radiologie

2008-07-01

The importance of fungal infection of the lung in immunocompromised patients has increased substantially during the last decades. Numerically the most patients are those with neutropenia, e.g. patients with malignancies or solid organ and stem cell transplantation, chemotherapy, corticosteroid use and HIV infection. Although fungal infections can occur in immunocompetent patients, their frequency in this population is rare. The clinical symptoms such as fever accompanied with non-productive cough are unspecific. In some patients progression to hypoxemia and dyspnea may occur rapidly. In spite of improved antifungal therapy morbidity and mortality of these infections are still high. Therefore an early and non-invasive diagnosis is very important. That is why CT and even better High-Resolution-CT (HR-CT) is a very important modality in examining immunocompromised patients with a probability of fungal infection. CT is everywhere available and, as a non-invasive method, able to give the relevant diagnose efficiently. This paper should give an overview about the radiologic findings and possible differential diagnosis of diverse pulmonary fungal infections in CT. Pneumonias caused by Aspergillus, Cryptococcus, Candida, Histoplasma, Mucor and Geotrichum capitatum are illustrated. (orig.)

CT scan findings of fungal pneumonia

International Nuclear Information System (INIS)

Heckmann, M.; Uder, M.; Bautz, W.; Heinrich, M.

2008-01-01

The importance of fungal infection of the lung in immunocompromised patients has increased substantially during the last decades. Numerically the most patients are those with neutropenia, e.g. patients with malignancies or solid organ and stem cell transplantation, chemotherapy, corticosteroid use and HIV infection. Although fungal infections can occur in immunocompetent patients, their frequency in this population is rare. The clinical symptoms such as fever accompanied with non-productive cough are unspecific. In some patients progression to hypoxemia and dyspnea may occur rapidly. In spite of improved antifungal therapy morbidity and mortality of these infections are still high. Therefore an early and non-invasive diagnosis is very important. That is why CT and even better High-Resolution-CT (HR-CT) is a very important modality in examining immunocompromised patients with a probability of fungal infection. CT is everywhere available and, as a non-invasive method, able to give the relevant diagnose efficiently. This paper should give an overview about the radiologic findings and possible differential diagnosis of diverse pulmonary fungal infections in CT. Pneumonias caused by Aspergillus, Cryptococcus, Candida, Histoplasma, Mucor and Geotrichum capitatum are illustrated. (orig.)

The librarian as research informationist: a case study.

Science.gov (United States)

Federer, Lisa

2013-10-01

How can an embedded research informationist add value to the scientific output of research teams? The University of California-Los Angeles (UCLA) Louise M. Darling Biomedical Library is an academic health sciences library serving the clinical, educational, and research needs of the UCLA community. A grant from the National Library of Medicine funded a librarian to join a UCLA research team as an informationist. The informationist meets regularly with the research team and provides guidance related to data management, preservation, and other information-related issues. Early results suggest that the informationist's involvement has influenced the team's data gathering, storage, and curation methods. The UCLA Library has also changed the librarian's title to research informationist to reflect the new activities that she performs. The research informationist role provides an opportunity for librarians to become effective members of research teams and improve research output.

Public speaking: creating presentations that are awe inspiring not yawn producing.

Science.gov (United States)

DeVan, Marsheila; Baum, Neil

2013-01-01

Many physicians want to be good platform speakers; however, few of us have the background and training necessary to be an outstanding public speaker. Yes, we all have slide decks and PowerPoint programs provided to us so that we can turn our backs to the audience and read the verbiage on the slides. But does that technique generate useful information to the audience? Or if speaking to a lay audience, does that kind of talk make the audience members get out their cell phones and call the office to make an appointment in our practice? Probably not. This article will provide suggestions that will enhance your speaking and presentation skills. This, in turn, will make you a darling of the pharma industry and encourage potential patients in your audience to become patients in your practice.

Epidemia de tuberculosis multidrogo resistente y extensivamente resistente a drogas (TB MDR/XDR en el Perú: situación y propuestas para su control

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Hernán Del Castillo

2009-07-01

Full Text Available En este artículo se describe el estado actual de las epidemias de tuberculosis multidrogo resitente (TB MDR y tuberculosis extensivamente resistente a drogas (TB XDR en el Perú. Se realiza un análisis de nuestra situación con respecto al resto de Latinoamérica, y de la distribución temporo espacial de los casos de TB XDR en Lima. También presentamos nuestra reflexión de lo que está pasando y debe cambiar; lo que se resume en darle la importancia debida a un problema que nos está rebasando y anteponer a nuestros propios intereses, los intereses de la humanidad; por consiguiente no podemos callar, y debemos declarar a la tuberculosis como emergencia sanitaria nacional. Eso constituye una respuesta, esperamos, aún viable para el Perú.

Linfoma orbitario: reporte de un caso y revisión de la literatura

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Javier Andrés Galnares Olalde

2014-07-01

Full Text Available El linfoma orbitario es un tipo de tumor muy infrecuente que afecta a la órbita y a sus anexos. En raras ocasiones es bilateral. Es de vital importancia hacer un diagnóstico temprano para darle un tratamiento oportuno y así prevenir complicaciones. Nosotros reportamos un caso de un paciente del sexo femenino de 66 años que se presenta al servicio de urgencias de oftalmología por una celulitis periorbitaria. Al no remitir el cuadro, se le hospitalizó para realizar estudios complementarios que concluyeron que se trataba de un linfoma no Hodgkin de tipo B de la zona marginal (MALT. Los aspectos referentes a este tipo de linfoma como su epidemiología, etiología, etapas, diagnóstico y tratamiento se discuten en este reporte de caso.

La definición jurídica del fenómeno metropolitano en el ámbito subnacional mexicano

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Alberto Arellano Ríos

2014-10-01

Full Text Available En este texto se analiza la definición jurídica del fenómeno metropolitano en seis Estados de la república mexicana. Se estudian seis legislaciones estatales creadas expresamente para atender y darle forma jurídica a un problema que se ha acentuado con mayor fuerza en México, el cual desde el punto de vista de las instancias gubernamentales tiene mayor relevancia en los últimos veinte años. De este modo, el documento esboza el fenómeno metropolitano como contexto social. Luego traza los mecanismos constitucionales contemplados para gestionar y gobernar las zonas metropolitanos para, finalmente, exponer los casos estatales que ante la ausencia de un marco legal nacional, y desde la lógica del sistema federal, intentan sentar bases jurídicas para resolver este problema.

Principales prácticas de recursos humanos de las PyMEs industriales exitosas.

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Liliana Rocío López Suárez

2013-04-01

Full Text Available El éxito competitivo de la PyME depende en parte de la buena gestión de recursos humanos,por lo que no darle el valor que requiere constituye una de las principales causas de fracasode estas empresas. La responsabilidad de la gestión eficaz de los recursos humanos recae fundamentalmenteen los directivos. La presente investigación tiene como objetivo identificarlos estilos de dirección y las principales prácticas de recursos humanos que llevan a cabo lasPyMEs industriales exitosas de México y España. Para alcanzar los objetivos antes reseñados,se ha realizado un análisis documental, así como entrevistas en profundidad a expertosen el área de recursos humanos. En este trabajo se presentan los principales resultados conrespecto a las prácticas mencionadas.

El mundo rural latinoamericano y la nueva ruralidad

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Edelmira Pérez C.

2004-04-01

Full Text Available Es indudable la importancia del debate actual en América Latina acerca de las nuevas concepciones del desarrollo rural. Se empieza a presentar una coincidencia en la necesidad de darle a éste un enfoque territorial y a ello ha contribuido el aporte de la mirada de desarrollo rural de la Unión Europea, pero también la visión de “nueva ruralidad” que han venido planteando distintos estudiosos del continente, de manera especial en los últimos diez años.Aunque el mundo rural ha tenido grandes transformaciones, aún persisten en América Latina rezagos estructurales que impiden la incorporación de las áreas rurales y de sus pobladores a las dinámicas actuales del desarrollo los cuales son analizados en este artículo.

EL MUNDO RURAL LATINOAMERICANO Y LA NUEVA RURALIDAD

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Edelmira Pérez C.

2004-01-01

Full Text Available Es indudable la importancia del debate actual en América Latina acerca de las nuevas concepciones del desarrollo rural. Se empieza a presentar una coincidencia en la necesidad de darle a éste un enfoque territorial y a ello ha contribuido el aporte de la mirada de desarrollo rural de la Unión Europea, pero también la visión de "nueva ruralidad" que han venido planteando distintos estudiosos del continente, de manera especial en los últimos diez años. Aunque el mundo rural ha tenido grandes transformaciones, aún persisten en América Latina rezagos estructurales que impiden la incorporación de las áreas rurales y de sus pobladores a las dinámicas actuales del desarrollo los cuales son analizados en este artículo.

Stenotik Biküspid Aort Kapak Anomalisi Efor Sonrası Ani Ölüm Olgusu

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Elif Ülker Akyıldız

2006-12-01

Full Text Available Biküspid aort kapağı, erişkinde aort darlığının sık nedeni olan, toplumda %l-2 oranında görülen, bazen hiçbir bulgu vermeyen bir konjenital kalp kapak anomalisidir. Erkeklerde üç-dört kat daha sıklıkla görülmektedir. Aort kapak prolapsusu, aort stenozu, aort regurjitasyonu ile birliktelik gösterebilir. Bu sunuda; efor (spor sonrası baş dönmesi şikayeti ile hastaneye kaldırılan ve aynı gün ölen, 14 yaşında erkek olgu sunulmuştur. Otopside; dış muayenede travmatik bulgu tespit edilmemiştir. İç muayenede; akciğer ağırlıkları artmış, kesitleri ödemli, kalp 380 g ağırlıkta, sağ ventrikül duvar kalınlığı 0,4 cm, sol ventrikül duvar kalınlığı 2 cm ölçülmüştür. Aort kapağının toplam uzunluğu 3,8 cm ölçülmüş, fibrotik kalınlaşma gösteren iki kapakçık görülmüştür. Histopatolojik incelemede; myokartta hipertrofi, aort kapağında bağ dokusu artışı ile fibrotik kalınlaşma, kalsifikasyon, aort duvarmda ara madde artışı, media tabakasında miksoid dejenerasyon tespit edilmiştir. Tüm bulgular eşliğinde ölüm nedeni biküspit aort kapağı zemininde gelişen aort darlığına bağlı kalp yetmezliği olarak değerlendirilmiştir. Olgunun klinik ve otopsi bulguları tartışılarak, ani ölüm olgularında kardiyak anomalilerin rolü ve otopsinin önemi vurgulamıştır. Anahtar kelimeler: Biküspid aort kapağı, otopsi, aort stenozu, ani ölüm.

Distribuições de probabilidade para séries históricas mensais de pressão atmosférica no município de Mossoró-RN

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Janilson Pinheiro de Assis

2016-08-01

Full Text Available Objetivou-se verificar o ajuste de 12 séries históricas de pressão atmosférica mensal (milibar no período de 1970 a2007, em Mossoró, RN, à sete modelos de distribuição densidade de probabilidade Normal, Log-Normal, Beta, Gama, Log-Pearson (Tipo III, Gumbel e Weibull, através dos testes Kolmogorov-Smirnov, Qui-Quadrado, Cramer Von-Mises, Anderson Darling e Kuiper a 10 % de probabilidade e utilizando-se o Logaritmo da Máxima Verossimilhança. Verificou-se a superioridade do ajustamento da distribuição de probabilidade Normal, quando comparada com as outras seis distribuições. No geral, os critérios de ajuste concordaram com a aceitação da hipótese H0, no entanto, deve-se salientar que o teste de Kolmogorov-Smirnov apresenta um nível de aprovação de uma distribuição sob teste muito elevado, gerando insegurança aos critérios do teste, porém, como neste estudo os dados são aproximadamente simétricos, esse é o mais recomendado.Probability distributions for historic series of monthly atmospheric pressure in city of Mossoró-RNAbstract: The aim of this study was to determine the set of 12 time series of monthly atmospheric pressure (millibars in the period 1970-2007, in Natal, RN, the seven models of the probability density distribution Normal, Log-Normal, Beta, Gamma, Log -Pearson (Type III, Gumbel and Weibull, through the Kolmogorov-Smirnov tests, Chi-Square, Cramer-von Mises, Anderson Darling and Kuiper 10 probability and using the logarithm of the maximum likelihood. It is the superiority of adjusting the normal probability distribution compared to the other six distributions. Overall, the fit criteria agreed with the acceptance of the hypothesis, however, it should be noted that the Kolmogorov-Smirnov test shows a level of approval of a distribution under test very high, which creates some uncertainty to the criteria of test, but in this study as the data are roughly symmetrical it is the most recommended.

Riverbank Collapse on the lower Murray River: recent phenomenon or long-term geomorphic process?

Science.gov (United States)

De Carli, E.; Hubble, T.; Jaksa, M.; Clarke, S. L.; Airey, D.; O'Toole, J.; Carpenter, G.

2013-12-01

The lower Murray River connects the Murray-Darling River Basin to the Southern Ocean and drains 14% of Australia's landmass. During the Millennium Drought (1997-2011) record low inflows for the Basin were recorded and the lower Murray River received only 19% of its long-term average inflow for 2008-2009, causing the pool-level in the lowermost reaches near Goolwa to fall 1 m below sea level. This event triggered widespread mass failure in the alluvial river banks and ground subsidence in some river-adjacent floodplain deposits between Blanchetown and Lake Alexandrina. Multi-beam bathymetry, sediment core and geotechnical data are presented for a number of sites investigated between Mannum and White Sands. Interpretation of this data indicates three different bank-failure slide morphologies present in the banks and adjacent channel. Type 1, ';recent' (2009-2011) deep-seated rotational slumps characterised by distinct, sharply-defined failure scars and associated debris fields of angular blocks shed from the failure site. Type 2, ';relatively-recent' shallow planar-failures, with less well-defined smoother failure scars and associated debris fields of smoothed or rounded blocks and pinnacles. Type 3, ';relatively-old' shallow planar-failures characterised by subdued relief slump scars that do not present an associated debris field. It is suspected that successive floods or high-flow events progressively erode and redistribute material, smoothing the landslide scars and redistributing the slide-debris deposits. Bank-failure and the delivery of material from the slides into the channel is interpreted as an ongoing and long-term geomorphic characteristic of the lower Murray River, rather than a new phenomenon that occurred as a response to unusually low river levels during the Millennium Drought. The larger size and rotational style of the recent Type 1 failures is most likely to be a consequence of the drought and anthropogenic modifications of the river channel and

Three-dimensional mapping of salt load in the Murray-Darling Basin, 1 Steps in calibration of airborne electromagnetic surveys

NARCIS (Netherlands)

Cresswell, R.G.; Dent, D.L.; Jones, G.; Galloway, D.

2004-01-01

An airborne electromagnetic survey yields a three-dimensional map of ground electrical conductivity. The remotely sensed data are translated into salt load by field and laboratory calibration: drilling, measurement of borehole conductivity, electrical conductivity of 1 : 5 soil¿water extracts

CERN at Arles: LHC featured in prestigious photography festival

CERN Multimedia

Jordan Juras

2011-01-01

Six photographs of the LHC experiment are being featured in this year’s Rencontres d’Arles photography festival. Simon Norfolk’s series, The LHC: the spirit of enquiry, was chosen as part of an exhibition celebrating 30 years of photography at the New York Times Magazine.   Simon Norfolk’s series "The LHC: the spirit of enquiry" on display at the Rencontres d'Arles festival. The photographs were originally taken in October 2006, when Norfolk was sent on an assignment to a ‘little known’ laboratory in Switzerland. “When I came to CERN, nobody I knew had ever heard of the place,” explains Norfolk. “Everybody I spoke to when I came back said, ‘You’ve been where? You’ve done what?’” Kathy Ryan, New York Times Magazine photo editor, sent Norfolk to ‘capture something new’. He describes Ryan’s assignments...

Truticultura y el excursionista en áreas rurales.

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Celia Guzmán Hernández

2013-01-01

Full Text Available La condición actual en algunos bosques mexicanos deriva de una historia de depredación socioeconómica y física; sin embargo en los espacios naturales donde el impacto no fue tan severo, la truticultura ha logrado establecerse como una actividad importante en el ramo pecuario, cuidando de manera constante tanto la calidad de las aguas como la salud animal por los comités de fomento. Desde los años setenta, los pequeños propietarios y ejidatarios han encontrado una alternativa de subsistencia representada por el producto y la posibilidad de darle un valor agregado a sus paisajes, incorporando los servicios restauranteros y recreativos con la finalidad de atender a los excursionistas; empero el aprovechamiento de los mantos acuíferos en los bosques representa amenazas diversas y cambiantes al paso de los años.

Book review: Inside the Equal Access to Justice Act: Environmental litigation and the crippling battle over America's lands, endangered species, and critical habitats

Science.gov (United States)

Organ, John F.

2016-01-01

Inside the Equal Access to Justice Act is authored by Lowell E. Baier, an attorney, political scientist, and historian whose conservation portfolio includes the J. N. “Ding” Darling Conservation Award from the National Wildlife Federation (2016), Citizen Conservationist Award from the Association of Fish and Wildlife Agencies (2013), Conservationist of the Year Award from Outdoor Life magazine (2010), and Conservationist of the Year Award from the National Fish and Wildlife Foundation (2008). In the book, Baier stresses the need to reform the Equal Access to Justice Act (EAJA) because of unintended provisions that incentivize and reward environmental litigants for filing suit against federal regulatory and land management agencies, consequentially hindering pro-active, cooperative, conservation efforts. The book is the culmination of several years of legal research, case history analyses, and personal interviews with several key individuals from congress, conservation management agencies, and non-government organizations.

Precampañas en Medellín y Antioquia

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Diego Calle Pérez

2015-08-01

Full Text Available Empiezan aireando con sus vallas, camisetas y visitas a barrios. Convocan a periodistas a desayunos, con algunos almuerzan y con otros toman traguito en fincas o los invitan a sus casas. Llaman a los amigos, conocidos y parientes de los tantos contactos que tienen en una agenda o en la memoria del celular. Buscan a como dé lugar la foto con el expresidente. Tienen varios avales de partidos políticos, pero no se saben cuál les conviene más y prefieren en algunos casos, la consulta interna. Hacen cuenta de las personas que tienen en su equipo y de cuantas conexiones se pueden hacer efectivas a la hora de un voto. Hablan con diputados electos, con concejales en ejercicio, con funcionarios que puedan darles información confidencial. Algunos llaman a los alcaldes amigos de los diferentes municipios

How to Write (Even) Better Academic Student Reports and Papers

DEFF Research Database (Denmark)

Prætorius, Thim

2017-01-01

and Content of an Academic Report/Paper covers the seven required parts that make up an academic piece of work. That is, introduction (e.g., setting the hook), theory and/or literature review (e.g., which literature to you draw on and contribute to), methods (how did you study the research question), findings......Writing good academic papers or reports that demonstrate academic rigour is not necessarily easy for university students (or academics for that matter). Common problems include lacking academic rigour when studying the research problem and difficulties in identifying literature and using theo-ry...... students write methods before theory but doing so means you need to operationalize theory before you have introduced it. The second theme, Gen-eral Tips and Tricks, provide rules of thumb (e.g., that you should kill your darlings), writing style and argumentation hints (e.g., use direct voice) and layout...

The Complete Book of Spaceflight: From Apollo 1 to Zero Gravity

Science.gov (United States)

Darling, David

2002-11-01

A commanding encyclopedia of the history and principles of spaceflight-from earliest conceptions to faster-than-light galaxy-hopping Here is the first truly comprehensive guide to space exploration and propulsion, from the first musings of the Greeks to current scientific speculation about interstellar travel using "warp drives" and wormholes. Space buffs will delight in its in-depth coverage of all key manned and unmanned missions and space vehicles-past, present, and projected-and its clear explanations of the technologies involved. Over the course of more than 2,000 extensively cross-referenced entries, astronomer David Darling also provides fascinating insights into the cultural development of spaceflight. In vivid accounts of the major characters and historical events involved, he provides fascinating tales of early innovators, the cross-pollination that has long existed between science fiction and science fact, and the sometimes obscure links between geopolitics, warfare, and advances in rocketry.

Evaluation of statistical distributions to analyze the pollution of Cd and Pb in urban runoff.

Science.gov (United States)

Toranjian, Amin; Marofi, Safar

2017-05-01

Heavy metal pollution in urban runoff causes severe environmental damage. Identification of these pollutants and their statistical analysis is necessary to provide management guidelines. In this study, 45 continuous probability distribution functions were selected to fit the Cd and Pb data in the runoff events of an urban area during October 2014-May 2015. The sampling was conducted from the outlet of the city basin during seven precipitation events. For evaluation and ranking of the functions, we used the goodness of fit Kolmogorov-Smirnov and Anderson-Darling tests. The results of Cd analysis showed that Hyperbolic Secant, Wakeby and Log-Pearson 3 are suitable for frequency analysis of the event mean concentration (EMC), the instantaneous concentration series (ICS) and instantaneous concentration of each event (ICEE), respectively. In addition, the LP3, Wakeby and Generalized Extreme Value functions were chosen for the EMC, ICS and ICEE related to Pb contamination.

The efficiency of average linkage hierarchical clustering algorithm associated multi-scale bootstrap resampling in identifying homogeneous precipitation catchments

Science.gov (United States)

Chuan, Zun Liang; Ismail, Noriszura; Shinyie, Wendy Ling; Lit Ken, Tan; Fam, Soo-Fen; Senawi, Azlyna; Yusoff, Wan Nur Syahidah Wan

2018-04-01

Due to the limited of historical precipitation records, agglomerative hierarchical clustering algorithms widely used to extrapolate information from gauged to ungauged precipitation catchments in yielding a more reliable projection of extreme hydro-meteorological events such as extreme precipitation events. However, identifying the optimum number of homogeneous precipitation catchments accurately based on the dendrogram resulted using agglomerative hierarchical algorithms are very subjective. The main objective of this study is to propose an efficient regionalized algorithm to identify the homogeneous precipitation catchments for non-stationary precipitation time series. The homogeneous precipitation catchments are identified using average linkage hierarchical clustering algorithm associated multi-scale bootstrap resampling, while uncentered correlation coefficient as the similarity measure. The regionalized homogeneous precipitation is consolidated using K-sample Anderson Darling non-parametric test. The analysis result shows the proposed regionalized algorithm performed more better compared to the proposed agglomerative hierarchical clustering algorithm in previous studies.

Comunicación y lenguaje en personas que se ubican dentro del espectro autista

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Ronald Soto Calderón

2007-01-01

Full Text Available Una de las mayores dificultades de las personas que se ubican dentro del espectro autista, está relacionado con los elementos semántico pragmáticos de la comunicación, no obstante, quienes tienen relación con ellas en un afán de satisfacer sus necesidades procuran darle “entender lo que ellas dicen” sin tener en cuenta que muchas veces son meras interpretaciones propias, situación que afecta el desarrollo y utilización de un método o una estrategia de enseñanza del lenguaje y la comunicación a estas personas. Con este artículo se pretende realizar un corto recorrido por las características del lenguaje en personas con autismo, y algunos métodos que podrían favorecer el desarrollo de destrezas comunicativas en ellas.

Bat in our environment

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Mirjana Stantič-Pavlinič

2005-04-01

Full Text Available Background: All around the world exist more than thousand species of bats. In spite of some advantageous characteristics, mostly recognised in several insectivorous species, bats can transmit different kinds of microorganisms – the causes of infectious diseases. Microbial agents, recognised in connection with bats are: lyssavirus, Nipah virus, Hystoplasma capsulatum fungus, etc. In Europe there live about 28 species of bats. The most cases of European bat lyssaviruses (EBL1 and EBL2 were demonstrated in the Eptesicus serotinus species placed in Slovenia as well. We are presenting available data on rabies prevention. The rate of post-exposure treatment against rabies after the bite of bats in Slovenia is below 1% and is comparable with the remainder of Europe.Conclusions: In most European countries, including Slovenia, the bats are included in the lists of animal species protected by the law. In spite of that, the programs of investigations of bats, including the recognition and prevention of diseases transmitted by bats are implemented. We believe that such program should be prepared in Slovenia as well. We propose for that purposes the establishment of co-operation between the medical institutions, veterinarians, cave explorers associations, societies for bat protections and other interested institutions.

Immunological assays employed for the elucidation of an histoplasmosis outbreak in São Paulo, SP

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Angela Noronha Passos

2014-12-01

Full Text Available Several reports showed outbreaks of histoplasmosis acquired while bat-inhabited caves were visited by tourists, miners or researchers. We evaluated the performance of double immunodifusion (DI and immunoblotting (IB assays, employed for the histoplasmosis outbreak elucidation occurred in Vale do Paraíba, São Paulo. The existence of epidemiologic link, four patients with clinical signs suggestive of histoplasmosis and mycological confirmation has made that all 35 individuals involved to the cave visit were subjected to serological evaluation. By DI, we observed reactivity against H. capsulatum antigen in a single serum examined nearly 20 days after exposure to fungal propagules. On the other hand, IB showed reactivity against H and M fractions in 50% of samples evaluated. The analysis of the second sample batch, collected two months after the exposure showed that 96.7% were reactive by DI with antibodies titers ranging from 1 to 16 and 100% of reactivity against H and M fractions, by IB, suggesting an acute infection. The analysis of the overall agreement between the methods showed to be reasonable (κ = 0.37. This study confirms the importance and efficacy of more sensitive methodologies, such as IB assay, to early elucidation of disease, especially in cases of patients without mycological information.

EMPIRICAL DISTRIBUTION OF STOCK RETURNS OF SOUTHEAST EUROPEAN EMERGING MARKETS

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Aleksandar Naumoski

2017-06-01

Full Text Available The assumption that equity returns follow the normal distribution, most commonly made in financial economics theory and applications, is strongly rejected by empirical evidence presented in this paper. As it was found in many other studies, we confirm that stock returns follow a leptokurtic distribution and skewness, which in most of the Southeast European (SEE markets is negative. This paper investigates further whether there is any distribution that may be considered an optimal fit for stock returns in the SEE region. Using daily, weekly and monthly data samples for a period of five years from ten Southeast European emerging countries, we applied the Anderson-Darling test of Goodness-of-fit. We strongly rejected the aforementioned assumption of normality for all considered data samples and found that the daily stock returns are best fitted by the Johnson SU distribution whereas for the weekly and monthly stock returns there was not one predominant, but many distributions that can be considered a best fit.

PERCEPCIÓN SOBRE LA RESPONSABILIDAD SOCIAL EMPRESARIA DE ESTUDIANTES UNIVERSITARIOS

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Estefanía Solari

2012-04-01

Full Text Available La presente investigación, estudia la percepción de la Responsabilidad Social Empresaria (RSE, que tienen jóvenes estudiantes de las carreras de ciencias económicas en la Argentina y Venezuela. El estudio de tipo exploratorio, con utilización de encuestas, mostró que el 97% de los encuestados argentinos y el 92% de los venezolanos, valoran la RSE como positiva y piensan que la misma es fundamentalmente marketing (en un 78% y un 82% respectivamente. Al momento de la compra de un producto el 76% los argentinos y el 93% los venezolanos, manifiestan darle poca o ninguna importancia a la RSE. A su vez, no se observan diferencias significativas originadas en la nacionalidad de los encuestados. De esta manera, es como se percibe que los encuestados consideran que los empresarios actúan como un verdadero “homo economicus”, poniendo de manifiesto la necesidad de “humanizar la economía”.

Evaluation of the best fit distribution for partial duration series of daily rainfall in Madinah, western Saudi Arabia

Science.gov (United States)

Alahmadi, F.; Rahman, N. A.; Abdulrazzak, M.

2014-09-01

Rainfall frequency analysis is an essential tool for the design of water related infrastructure. It can be used to predict future flood magnitudes for a given magnitude and frequency of extreme rainfall events. This study analyses the application of rainfall partial duration series (PDS) in the vast growing urban Madinah city located in the western part of Saudi Arabia. Different statistical distributions were applied (i.e. Normal, Log Normal, Extreme Value type I, Generalized Extreme Value, Pearson Type III, Log Pearson Type III) and their distribution parameters were estimated using L-moments methods. Also, different selection criteria models are applied, e.g. Akaike Information Criterion (AIC), Corrected Akaike Information Criterion (AICc), Bayesian Information Criterion (BIC) and Anderson-Darling Criterion (ADC). The analysis indicated the advantage of Generalized Extreme Value as the best fit statistical distribution for Madinah partial duration daily rainfall series. The outcome of such an evaluation can contribute toward better design criteria for flood management, especially flood protection measures.

Automatización Fuzzy aplicado en la contabilidad decisional

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Jaime Tinto Arandes

2016-06-01

Full Text Available El propósito de este trabajo es introducir la automatización en los instrumentos que la teoría de la incertidumbre contiene, dentro de las ciencias contables como herramienta fundamental para la toma de decisiones debido a la necesidad de darle al área contable una visión predictiva y dinámica. Con ello se pretende ir introduciendo los conceptos de la teoría de la incertidumbre para la construcción de los balances previsionales de situación y unos estados previsionales de resultados, donde quede atrapada toda la incertidumbre reinante en un horizonte de mediano y largo plazo para la correcta toma de decisiones. Para ello, es necesario partir del dato contable actual cierto, plasmado en los balances generales de la empresa y en los estados de resultados financieros, técnicas como el expertizaje y el contra-expertizaje, entre otras. Palabras clave: Modelo, contabilidad decisional, construcción.

Statistical homogeneity tests applied to large data sets from high energy physics experiments

Science.gov (United States)

Trusina, J.; Franc, J.; Kůs, V.

2017-12-01

Homogeneity tests are used in high energy physics for the verification of simulated Monte Carlo samples, it means if they have the same distribution as a measured data from particle detector. Kolmogorov-Smirnov, χ 2, and Anderson-Darling tests are the most used techniques to assess the samples’ homogeneity. Since MC generators produce plenty of entries from different models, each entry has to be re-weighted to obtain the same sample size as the measured data has. One way of the homogeneity testing is through the binning. If we do not want to lose any information, we can apply generalized tests based on weighted empirical distribution functions. In this paper, we propose such generalized weighted homogeneity tests and introduce some of their asymptotic properties. We present the results based on numerical analysis which focuses on estimations of the type-I error and power of the test. Finally, we present application of our homogeneity tests to data from the experiment DØ in Fermilab.

Climate change and irrigation. An Australian response

International Nuclear Information System (INIS)

Pigram, J.J.

1995-01-01

Climatic changes on a global or regional scale, resulting from human activities, and the likely effects of such changes on Australia were discussed. Irrigation concerns of the Murray-Darling Basin in southeast Australia associated with global climate were described. Potential risks for regional economies and communities (agriculture in this instance) which may be significant, were assessed. Restructuring of the irrigation industry, and appropriate policy initiatives were urged now, while there is still some time to prepare. Application of the 'Precautionary Principle' to reduce global climate change effects was recommended. (This principle states that in areas threatened by severe climatic change lack of full scientific certainty should not be used as an excuse to delay decisive measures designed to mitigate environmental degradation). Bold policy adjustments and the creation of a new institutional framework to promote sustainable resource management were called for. It was suggested that the region could become a 'laboratory' for the whole world for assessing the effectiveness of managerial responses to environmental changes

Phase space structure of triatomic molecules

International Nuclear Information System (INIS)

Lu, Z.; Kellman, M.E.

1997-01-01

The bifurcation structure is investigated for a Hamiltonian for the three coupled nonlinear vibrations of a highly excited triatomic molecule. The starting point is a quantum Hamiltonian used to fit experimental spectra. This Hamiltonian includes 1:1 Darling endash Dennison resonance coupling between the stretches, and 2:1 Fermi resonance coupling between the stretches and bend. A classical Hamiltonian is obtained using the Heisenberg correspondence principle. Surfaces of section show a pronounced degree of chaos at high energies, with a mixture of chaotic and regular dynamics. The large-scale bifurcation structure is found semianalytically, without recourse to numerical solution of Hamilton close-quote s equations, by taking advantage of the fact that the spectroscopic Hamiltonian has a conserved polyad quantum number, corresponding to an approximate constant of the motion of the molecule. Bifurcation diagrams are analyzed for a number of molecules including H 2 O, D 2 O, NO 2 , ClO 2 , O 3 , and H 2 S. copyright 1997 American Institute of Physics

A new species of freshwater eel-tailed catfish of the genus Tandanus (Teleostei: Plotosidae) from coastal rivers of mid-northern New South Wales, Australia

Science.gov (United States)

Welsh, Stuart A.; Jerry, Dean R.; Burrows, Damien; Rourke, Meaghan L.

2017-01-01

Tandanus bellingerensis, new species, is described based on specimens from four river drainages (Bellinger, Macleay, Hastings, and Manning rivers) of the mid-northern coast of New South Wales, Australia. Previously, three species were recognized in the genus Tandanus: T. tropicanus of the wet tropics region of northeast Queensland, T. tandanus of the Murray-Darling drainage and coastal streams of central-southern Queensland and New South Wales, and T. bostocki of southwestern Western Australia. The new species is distinguished from all congeners by a combination of the following morphologic characters: a high count of rays in the continuous caudodorsal and anal fins (range 153–169, mode 159), a high count of gill rakers on the first arch (range 35–39, mode 36), and strongly recurved posterior serrae of the pectoral-fin spine. Additionally, results from previously conducted genetic studies corroborate morphologic and taxonomic distinctness of the new species.

Implementation of Environmental Flows for Intermittent River Systems: Adaptive Management and Stakeholder Participation Facilitate Implementation

Science.gov (United States)

Conallin, John; Wilson, Emma; Campbell, Josh

2018-03-01

Anthropogenic pressure on freshwater ecosystems is increasing, and often leading to unacceptable social-ecological outcomes. This is even more prevalent in intermittent river systems where many are already heavily modified, or human encroachment is increasing. Although adaptive management approaches have the potential to aid in providing the framework to consider the complexities of intermittent river systems and improve utility within the management of these systems, success has been variable. This paper looks at the application of an adaptive management pilot project within an environmental flows program in an intermittent stream (Tuppal Creek) in the Murray Darling Basin, Australia. The program focused on stakeholder involvement, participatory decision-making, and simple monitoring as the basis of an adaptive management approach. The approach found that by building trust and ownership through concentrating on inclusiveness and transparency, partnerships between government agencies and landholders were developed. This facilitated a willingness to accept greater risks and unintended consequences allowing implementation to occur.

Consideraciones sobre la administración de proyectos de desarrollo de software, con ciclo de vida ágil, en el contexto costarricense

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Anayansie Fallas Badilla

2011-10-01

Full Text Available En Costa Rica, la adopción de metodologías ágiles para el desarrollo de software ha traído consigo nuevas interrogantes para los administradores de proyectos: ¿cómo planificar este tipo de proyectos?, ¿cómo darles control y seguimiento en su ejecución? ¿cuáles competencias son las deseables para quienes tengan que administrar este tipo de proyectos? Este artículo presenta un marco teórico al respecto, da un panorama general del desarrollo de software en Costa Rica y del profesional en tecnologías de la información con que cuenta el país, y a partir de lo anterior enumera una serie de consideraciones que puedan servir como guía para quien requiera administrar proyectos de desarrollo de software con este tipo de metodología en el contexto costarricense.

LAS CLÁUSULAS SELF - EXECUTING DE LOS CONVENIOS DE LA ORGANIZACIÓN INTERNACIONAL DEL TRABAJO EN MATERIA DE DERECHO LABORAL COLECTIVO (CONVENIOS 87 Y 98

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Francisco Rafael Ostau de Lafont de León

2013-01-01

Full Text Available El artículo hace referencia a la aplicabilidad interna de los Convenios de la Organización Inter- nacional de Trabajo (OIT en cuanto a la condición de que sus cláusulas deben de ser claras y precisas para que los operadores judiciales puedan darle aplicabilidad directa en la solución de conflictos. La tesis apunta a que las cláusulas self executing y non self executing, cuando se trata de convenios sobre Derechos Humanos, pueden ser aplicables directamente por el ope- rador judicial sin tener en cuenta los criterios de auto ejecución. El interrogante que se plantea en el presente caso consiste en que si los convenios en materia de derechos laboral colectivo contemplan cláusulas non self executing o, en caso de que las contemplen por ser convenios sobre derechos humanos, ¿estos convenios podrían ser de aplicación auto ejecutiva?

AFIKS BAHASA MELAYU RIAU DIALEK KAMPAR (Kajian Fungsi dan Makna

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Martius Martius

2016-08-01

Full Text Available In languages agglutination, so that a basic word can be used in a substitutions, the word must first obtain gramatikalisasi process. Bahasa Melayu Riau Kampar is a kind of language agglutination gramatikalisasinya process performed by affixation. This study aimed to describe the form of prefixes and suffixes, see the function prefixes and suffixes, and know the meaning arising from the process and sufiksasi prefiksasi. To achieve these objectives, the authors used data through the method of introspection. Once the data is collected, then analyzed using the methods and techniques distributional vanished. After the data is analyzed, the research concluded that the prefixes in the form BMRK consists of a prefix ma (N - di-, Perhaps, pa(N - arms, Ka, and darling. Then the form of the suffix is the suffix -ang -eng, -ong, -in, -un, -i, -ki, -pi, -ti, and an. The function is forming verb affixes, the active verb is transitive, intransitive verb active, passive verbs, and nouns forming.

Water scarcity: moving beyond indexes to innovative institutions.

Science.gov (United States)

Jarvis, W Todd

2013-01-01

Water scarcity is a media darling often times described as a trigger of conflict in arid regions, a by-product of human influences ranging from desertification to climate change, or a combination of natural- and human-induced changes in the water cycle. A multitude of indexes have been developed over the past 20 years to define water scarcity to map the "problem" and guide international donor investment. Few indexes include groundwater within the metrics of "scarcity." Institutional communication contributes to the recognition of local or regional water scarcity. However, evaluations that neglect groundwater resources may incorrectly define conditions as scarce. In cases where there is a perception of scarcity, the incorporation of groundwater and related storage in aquifers, political willpower, new policy tools, and niche diplomacy often results in a revised status, either reducing or even eliminating the moniker locally. Imaginative conceptualization and innovative uses of aquifers are increasingly used to overcome water scarcity. © 2013, National Ground Water Association.

Closed Form Representations of Some Series in Darling’s Model for Squeeze Film Damping with a Rectangular Plate

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Martin Gugat

2012-05-01

Full Text Available Compressible squeeze film damping is a phenomenon of great importance for micromachines. For example, for the optimal design of an electrostatically actuated micro-cantilever mass sensor that operates in air, it is essential to have a model for the system behavior that can be evaluated efficiently. An analytical model that is based upon a solution of the linearized Reynolds equation has been given by R.B. Darling. In this paper we explain how some infinite sums that appear in Darling’s model can be evaluated analytically. As an example of applications of these closed form representations, we compute an approximation for the critical frequency where the spring component of the reaction force on the microplate, due to the motion through the air, is equal to a certain given multiple of the damping component. We also show how some double series that appear in the model can be reduced to a single infinite series that can be approximated efficiently.

Culture, climate change and farm-level groundwater management: An Australian case study

Science.gov (United States)

Sanderson, Matthew R.; Curtis, Allen L.

2016-05-01

Cultural factors - values, beliefs, and norms - provide important insights into the environmental attitudes, risk perceptions, and behaviors of the general population. Little is known, however, about the ostensibly complex relationships linking those elements of culture to climate change risk perceptions, especially in the context of farm level decision in the ground water context. This paper addresses that gap through an analysis of survey data provided by irrigators in the Namoi catchment of Australia's Murray-Darling Basin. We use Values-Beliefs-Norms theory to construct multivariate models of the relationship between ground water irrigators' interpretations of climate change risks and their implementation of adaptive water conservation practices. Results indicate that these cultural factors are important explanations of irrigators' climate change risk perceptions, and these risk perceptions are related to adaptive ground water management strategies at the farm level. The implications of the findings are discussed for research on the culture-environment nexus and for outreach designed to encourage agricultural adaptations to climate change.

Evaluation of the best fit distribution for partial duration series of daily rainfall in Madinah, western Saudi Arabia

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F. Alahmadi

2014-09-01

Full Text Available Rainfall frequency analysis is an essential tool for the design of water related infrastructure. It can be used to predict future flood magnitudes for a given magnitude and frequency of extreme rainfall events. This study analyses the application of rainfall partial duration series (PDS in the vast growing urban Madinah city located in the western part of Saudi Arabia. Different statistical distributions were applied (i.e. Normal, Log Normal, Extreme Value type I, Generalized Extreme Value, Pearson Type III, Log Pearson Type III and their distribution parameters were estimated using L-moments methods. Also, different selection criteria models are applied, e.g. Akaike Information Criterion (AIC, Corrected Akaike Information Criterion (AICc, Bayesian Information Criterion (BIC and Anderson-Darling Criterion (ADC. The analysis indicated the advantage of Generalized Extreme Value as the best fit statistical distribution for Madinah partial duration daily rainfall series. The outcome of such an evaluation can contribute toward better design criteria for flood management, especially flood protection measures.

Una herramienta para la inclusión de alumnos/as con necesidades educativas especiales: el aprendizaje cooperativo

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Javier FERNÁNDEZ-RÍO

2009-11-01

Full Text Available RESUMEN: La atención del alumnado con necesidades educativas especiales en la Enseñanza Secundaria debe hacerse de una manera adecuada en todos los sentidos. Muchos consideran que con situar a este tipo de alumnado dentro de las aulas es suficiente; pero no se dan cuenta de que existen muchos alumnos/as de este tipo, y que para darles un tratamiento adecuado real hay que emplear métodos de enseñanza adecuados como parece ser el aprendizaje cooperativo.ABSTRACT: The treatment of students with special needs in Secondary Education has to be done in a proper way. Many believe that it is enough when you place those type of students in regular classrooms; but they do not realize that there are many of this type of students, and if you want to give them a real and adequate response you have to use adequate teaching methods like the cooperative learning seems to be.

EL ROL DE LOS PADRES EN LA FORMACIÓN FUTBOLÍSTICA DEL NIÑO

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Luis Roberto Sibaja Quesada

2003-12-01

Full Text Available La vivencia de un niño al involucrarse en cualquier deporte es condicionada por la mentalidad de sus padres. Frecuentemente, éstos transmiten a sus hijos sus propias motivaciones, frustraciones y sueños truncados. Indudablemente, los padres que no quieren dañar la experiencia deportiva de su hijo y en consecuencia el desarrollo de su personalidad, deben considerar cuidadosamente el sentido que ellos, atribuyen al deporte, su forma de visualizarlo y la manera en que intentan vivir la experiencia deportiva de su niño. En este período de la vida del niño es importante darle la posibilidad de realizar sus propias escogencias relacionadas con sus deseos de practicar algún deporte, la función de los padres es apoyarlo y orientarlo con relación a la preferencia del infante, nunca convertirse en una figura presionante que influya tendenciosamente en lo que el niño quiere hacer con su tiempo recreacional o deportivo.

Opportunities and Barriers for Water Co-Governance—A Critical Analysis of Seven Cases of Diffuse Water Pollution from Agriculture in Europe, Australia and North America

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Morten Graversgaard

2018-05-01

Full Text Available Diffuse Water Pollution from Agriculture (DWPA and its governance has received increased attention as a policy concern across the globe. Mitigation of DWPA is a complex problem that requires a mix of policy instruments and a multi-agency, broad societal response. In this paper, opportunities and barriers for developing co-governance, defined as collaborative societal involvement in the functions of government, and its suitability for mitigation of DWPA are reviewed using seven case studies in Europe (Poland, Denmark, Sweden, The Netherlands and UK, Australia (Murray-Darling Basin and North America (State of Minnesota. An analytical framework for assessing opportunities and barriers of co-governance was developed and applied in this review. Results indicated that five key issues constitute both opportunities and barriers, and include: (i pressure for change; (ii connected governance structures and allocation of resources and funding; (iii leadership and establishment of partnerships through capacity building; (iv use and co-production of knowledge; and (v time commitment to develop water co-governance.

La industria francesa del cemento su evolución, sus tendencias

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Coiffu, Pierre

1961-06-01

Full Text Available Not availableSeñores: Habiéndome pedido mi querido amigo don Julián Rezola les expusiera a ustedes la evolución de la industria del cemento en la Franela Metropolitana, desde unos años acá, así como sus tendencias actuales, voy a tratar de corresponder de la mejor manera a esta invitación, que tanto me satisface como me honra. Empezaré por situar la industria francesa del cemento, indicando sus características principales, así como los factores que han influido en su evolución, para luego explicarles la manera de cómo los fabricantes han ido resolviendo los problemas que se les han presentado, y examinar sucesivamente la evolución de las diferentes secciones y servicios de una fábrica de cemento. Finalmente, voy a precisarles los resultados de conjunto obtenidos por nuestra industria, y trataré de darles algunas indicaciones sobre sus previsiones futuras.

Efficacy of Pseudomonas fluorescens strain CL145A spray dried powder for controlling zebra mussels adhering to native unionid mussels within field enclosures

Science.gov (United States)

Luoma, James A.; Weber, Kerry L.; Severson, Todd J.; Mayer, Denise A.

2015-01-01

The efficacy of a commercially prepared spray dried powder (SDP) formulation of Pseudomonas fluorescens (strain CL145A) was evaluated for removing zebra mussels (Dreissena polymorpha) adhering to a population of unionid mussels in Lake Darling (Alexandria, Minnesota). Two groups of unionid mussels were used in the study. Unionid mussels were collected near the test area, weighed, photographed, individually tagged, and randomly allocated to one of nine test enclosures in equal proportions and then divided into two groups. The first group of unionid mussels (Group 1, n = 5 per test enclosure) were indiscriminately selected from each test enclosure and used to estimate the number of zebra mussels adhering to unionid mussels prior to exposure. The second group of unionid mussels (Group 2, n = 22 per test enclosure) were used to evaluate the efficacy of SDP for removal of adhering zebra mussels. Both Group 1 and Group 2 mussels were used to evaluate the effects of SDP exposure on unionid mussel survival.

La geografía como disciplina integral: notas teóricas y empíricas

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Mauricio Herrera Rodríguez

2010-01-01

Full Text Available Este artículo responde al llamado a trascender las divisiones tradicionales entre Ciencias Sociales, Naturales y Humanidades y subraya cómo la Geografía ha internalizado muchos de los más recientes aportes teóricos y empíricos elaborados desde estas áreas, en un esfuerzo transdisciplinario por entender mejor la realidad socioambiental. Para darle coherencia teórica y relevancia práctica a este sincretismo intelectual, se propone un marco conceptual no reduccionista, elaborado por el geógrafo humanista Robert D. Sack (1997, 2003, 2010. Con el objetivo de ilustrar su pertinencia empírica, se discuten algunos paralelismos entre sus postulados y los propuestos por la "Evaluación de los ecosistemas del milenio" (2003 y por varios intelectuales destacados. Finalmente, se señala su potencial para responder constructivamente tanto al avasallador triunfalismo del mercado, como al relativismo desorientador y paralizante que con frecuencia domina nuestras discusiones públicas e intelectuales.

Reanimating Lost Landscapes: Bringing Visualisation to Aboriginal History

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Peter Read

2010-12-01

Full Text Available In Public History Review volume 11, Peter Osborne called for the methodologies of environmental history to be brought more securely and more imaginatively into public history. Environmental history by its own definition, he argued, encompassed Indigenous, ethnic and Anglo-Celtic histories, and heritages natural and built, material and intangible. I believe too that we public historians need to Incorporate changing landscapes and topographies as a vital element in understanding why communities and their built heritages constantly transfigure. Sometimes a single geographic factor such as the northern Gulf Stream can go far to explain the spectacular rise of a small island like Great Britain to world power. Equally we can help to explain the precipitous decline of towns like Bourke by degradation and siltation in the Darling River. This paper uses the case study of the Narrabeen town camp to explore the potential of digital visual technologies in Aboriginal History.

The Portable Sawmill and Other Challenges to REDD+ in Papua New Guinea

DEFF Research Database (Denmark)

Dalsgaard, Steffen; Pedersen, Marianne

The future for REDD+ in Papua New Guinea (PNG) seems uncertain in these days. Logging companies are accessing much land via a controversial legal framework (Special Agricultural Business Lease), while conservation-oriented NGOs are struggling to find schemes to stop the deforestation. After the f......', where landowners log their own trees may paradoxically be the biggest challenge to conservation in PNG rather than its last hope.......The future for REDD+ in Papua New Guinea (PNG) seems uncertain in these days. Logging companies are accessing much land via a controversial legal framework (Special Agricultural Business Lease), while conservation-oriented NGOs are struggling to find schemes to stop the deforestation. After...... the failure of voluntary carbon trade due largely to scams, REDD+ has been their new darling. However, there are currently only a few pilot projects mainly in areas, without large-scale logging. This paper argues that to understand the possibility for successfully implementing REDD+, one must look...

The Narrative Voice in Aiwei’s Comrade Darling%艾伟《爱人同志》的叙述声音

Institute of Scientific and Technical Information of China (English)

2015-01-01

The narrative skills of Ai Wei’s novel Comrade Darlin g has achieved positive results in narrating voice.External things like narration and internal subjective mind like organic configuration,in-tersection,indirect speech and free direct speech integration,accommodation,description,evaluation, interpretation of the story,the narrator’s voice is compatible and sequent,which is an organic,blend, appropriate means Comrade Darlin g adopts in expressing the narrator’voice both inside and outside the story.%艾伟长篇小说《爱人同志》的叙述技巧在叙述声音方面取得了积极成效。外在客观事象的叙述与内在主观心象的有机配置、交汇，间接引语和自由直接引语的整合、融通，描述、评价、阐释时故事内、外叙述者声音的共通、一致，是《爱人同志》故事内叙述者的声音和故事外叙述者的声音有机混融、恰适化约的主要方式。

76 FR 16637 - J.N. “Ding” Darling NWR, Lee County, FL; Final Comprehensive Conservation Plan and Finding of No...

Science.gov (United States)

2011-03-24

... available in the CCP: (1) Wildlife observation and photography--including walking, hiking, motorized and non...--including walking, hiking, motorized and non-motorized boating, and motorized and non-motorized trail use.... Further benefits will be realized from increased control of exotic, invasive, and nuisance species. We...

Wide-area estimates of evapotranspiration by red gum (Eucalyptus camaldulensis) and associated vegetation in the Murray-Darling River Basin, Australia

Science.gov (United States)

Nagler, Pamela L.; Doody, Tanya M.; Glenn, Edward P.; Jarchow, Christopher J.; Barreto-Munoz, Armando; Didan, Kamel

2016-01-01

Floodplain red gum forests (Eucalyptus camaldulensis plus associated grasses, reeds and sedges) are sites of high biodiversity in otherwise arid regions of southeastern Australia. They depend on periodic floods from rivers, but dams and diversions have reduced flood frequencies and volumes, leading to deterioration of trees and associated biota. There is a need to determine their water requirements so environmental flows can be administered to maintain or restore the forests. Their water requirements include the frequency and extent of overbank flooding, which recharges the floodplain soils with water, as well as the actual amount of water consumed in evapotranspiration (ET). We estimated the flooding requirements and ET for a 38 134 ha area of red gum forest fed by the Murrumbidgee River in Yanga National Park, New South Wales. ET was estimated by three methods: sap flux sensors placed in individual trees; a remote sensing method based on the Enhanced Vegetation Index from MODIS satellite imagery and a water balance method based on differences between river flows into and out of the forest. The methods gave comparable estimates yet covered different spatial and temporal scales. We estimated flood frequency and volume requirements by comparing Normalized Difference Vegetation Index values from Landsat images with flood history from 1995 to 2014, which included both wet periods and dry periods. ET during wet years is about 50% of potential ET but is much less in dry years because of the trees' ability to control stomatal conductance. Based on our analyses plus other studies, red gum trees at this location require environmental flows of 2000 GL yr−1 every other year, with peak flows of 20 000 ML d−1, to produce flooding sufficient to keep them in good condition. However, only about 120–200 GL yr−1 of river water is consumed in ET, with the remainder flowing out of the forest where it enters the Murray River system.

Differences in Prokaryotic Species Between Primary and Logged-Over Deep Peat Forest in Sarawak, Malaysia

International Nuclear Information System (INIS)

Mohd Shawal Thakib Maidin; Sakinah Safari; Nur Aziemah Ghani; Sharifah Azura Syed Ibrahim; Shamsilawani Ahamed Bakeri; Mohamed Mazmira Mohd Masri; Siti Ramlah Ahmad Ali

2016-01-01

Peat land has an important role in environmental sustainability which can be used for agricultural purposes. However, deforestation in the logged-over forest may disrupt the diversity of microbial population in peat soil. Therefore, this study focuses on the differences of microbial populations in Maludam primary forest and Cermat Ceria logged-over forest in Sarawak, Malaysia. The prokaryotic 16S rDNA region was amplified followed by denaturing gradient gel electrophoresis (16S PCR-DGGE) analysis. Berger-Parker and Shannon-Weaver Biodiversity Index showed that Maludam (0.11, 7.75) was more diverse compared to Cermat Ceria (0.19, 7.63). Sequence analysis showed that the bacterial community in Maludam and Cermat Ceria were dominated by unclassified bacteria, followed by Acidobacteria, Actinobacteria, Firmicutes and a-Proteobacteria. Based on the findings, the distinct species that can be found in Maludam were Acidobacterium capsulatum, Solibacter sp., Mycobacterium intracellulare, Rhodoplanes sp., Clostridia bacterium, Exiguobacterium sp. and Lysinibacillus fusiformis. While, the distinct species that can be found in Cermat Ceria were Telmatobacter, Mycobacterium tuberculosis and Bacillus tequilensis. Overall, the findings showed that microbial population in the logged-over forest are less diverse compared to primary forest. Higher prokaryotic diversity identified in the primary forest compared to logged-over forest showed that deforestation might cause prokaryotic population changes to both ecosystems. (author)

Tuber indicum shapes the microbial communities of ectomycorhizosphere soil and ectomycorrhizae of an indigenous tree (Pinus armandii)

Science.gov (United States)

Li, Qiang; Zhao, Jian; Xiong, Chuan; Li, Xiaolin; Chen, Zuqin; Li, Ping; Huang, Wenli

2017-01-01

The aim of this study was to investigate the effect of an ectomycorrhizal fungus (Tuber indicum) on the diversity of microbial communities associated with an indigenous tree, Pinus armandii, and the microbial communities in the surrounding ectomycorhizosphere soil. High-throughput sequencing was used to analyze the richness of microbial communities in the roots or rhizosphere of treatments with or without ectomycorrhizae. The results indicated that the bacterial diversity of ectomycorhizosphere soil was significantly lower compared with the control soil. Presumably, the dominance of truffle mycelia in ectomycorhizosphere soil (80.91%) and ectomycorrhizae (97.64%) was the main factor that resulted in lower diversity and abundance of endophytic pathogenic fungi, including Fusarium, Monographella, Ustilago and Rhizopus and other competitive mycorrhizal fungi, such as Amanita, Lactarius and Boletus. Bacterial genera Reyranena, Rhizomicrobium, Nordella, Pseudomonas and fungal genera, Cuphophyllus, Leucangium, Histoplasma were significantly more abundant in ectomycorrhizosphere soil and ectomycorrhizae. Hierarchical cluster analysis of the similarities between rhizosphere and ectomycorrhizosphere soil based on the soil properties differed significantly, indicating the mycorrhizal synthesis may have a feedback effect on soil properties. Meanwhile, some soil properties were significantly correlated with bacterial and fungal diversity in the rhizosphere or root tips. Overall, this work illustrates the interactive network that exists among ectomycorrhizal fungi, soil properties and microbial communities associated with the host plant and furthers our understanding of the ecology and cultivation of T. indicum. PMID:28410376

Wildlife and habitat damage assessment from Hurricane Charley: recommendations for recovery of the J. N. "Ding" Darling National Wildlife Refuge Complex

Science.gov (United States)

Meyers, J. Michael; Langtimm, Catherine A.; Smith, Thomas J.; Pednault-Willett, Kendra

2006-01-01

• On 13 August 2004, the first of four hurricanes to strike Florida in Key waterbird nesting areas had >50% and sometimes 90% of their vegetation severely damaged (dead, broken tree stems, and tipped trees). The Shell Mound Trail area of JNDDNWR sustained catastrophic damage to its old growth mangrove forests. Direct storm mortality and injury to manatees in the area of the JNDDNWR Complex was probably slight as manatees may have several strategies to reduce storm mortality. Damage to seagrass beds, an important habitat for manatees, fishes and invertebrates, is believed to be limited to the breach at North Captiva Island. At this breach, refuge staff documented inundation of beds by sand and scarring by trees dragged by winds. • Because seagrass beads and manatee habitat extend beyond refuge boundaries (see p. 28), a regional approach with partner agencies to more thoroughly assess storm impacts and monitor recovery of seagrass and manatees is recommended. • Besides intensive monitoring of waterbirds and their nesting habitat (pre- and post-storm), the survey team recommends that the Mangrove Cuckoo be used as an indicator species for recovery of mangrove forests and also for monitoring songbirds at risk (this songbird is habitat-area sensitive). Black-whiskered Vireo may be another potential indicator species to monitor in mangrove forests. Monitoring for these species can be done by distance sampling on transects or by species presenceabsence from point counts. • Damaged vegetation should be monitored for recovery (permanent or long-term plots), especially where previous study plots have been established and with additional plots in mangrove forests of waterbird nesting islands and freshwater wetlands. • Potential loss of wetlands (and information for management) may be prevented by water level monitoring (3 permanent stations), locating the positions (GPS-GIS) and maintaining existing water control structures, creating a GIS map of the refuge with accurate vertical data, and monitoring and eradicating invasive plants. Invasive species, including Brazilian pepper (Schinus terebinthifolius) and air potato (Dioscorea bulbifora), were common in a very limited survey and may become more dominant in areas damaged by the storm. Special attention is needed to eradicate these exotic plants. • As an important monitoring goal, the survey team recommends that species presence-absence data analysis (with probability of detection) be used to determine changes in animal communities. This could be accomplished possibly with comparison to other storm-damaged and undamaged refuges in the Region. This information may be helpful to refuge managers when storms return in the future.

Les Representations Sociales de la Ville Chez les Ecoliers de Deux Villes Europeennes, d'Arles et de Sparte: Une Approche Comparative.

Science.gov (United States)

Zafeirakou, Aegli

1998-01-01

In an exchange program, 11- and 12-year olds from Arles (France) (n=25) and Sparta (Greece) (n=27) visited each other's cities and explored the culture and history. This study explores the ways they conceptualized the cultural patrimony of both cities through student drawings. The exchange created opportunities for dialog about European culture.…

Valor de los metodos directos e indirectos de diagnóstico en las micosis sitémicas asociadas al SIDA Efficacy of different diagnosis methods in systemic mycoses associated with AIDS

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A.I. Arechavala

1993-04-01

Full Text Available Durante 5 años se estudiaron 117 pacientes con micosis sistémicas asociadas al SIDA: 74 criptococosis, 39 histoplasmosis y 4 con ambas enfermedades. Para el diagnóstico analizamos los siguientes materiales: escarificaciones de lesiones cutáneas o mucosas, aspirados de médula ósea, secreciones bronquiales, biopsias de diversos órganos, líquido cefalorraquídeo, hemocultivos y sueros para determinaciones serológicas. Fueron estudiadas en total 203 muestras de pacientes con histoplasmosis, el 46.3% de las mismas acusó la presencia de H. capsulatum. Las escarificaciones cutáneas exhibieron la mayor sensibilidad (94.7%, seguidas por las biopsias (80% y los mielocultivos (42.1%. La demostración de anticuerpos circulantes por medio de 3 pruebas serológicas y con de 2 antígenos específicos dio resultados positivos en el 45.4% de los pacientes. Se estudiaron en total 413 especímenes de pacientes con criptococosis, la confirmación diagnóstica fue posible en el 69% de las muestras. El mayor rendimiento se obtuvo con el LCR (89.5%, le seguieron en sensibilidad los hemocultivos (61.2%, las escarificaciones cutáneas (42.9% y los urocultivos (41.7%. La búsqueda de antígeno en los fluidos orgánicos fue positiva en casi todos los casos. La revisión que presentamos permitirá una búsqueda más racional y rápida de los métodos de diagnóstico en las micosis asociadas al SIDA.One hundred and seventeen patients suffering systemic mycosis and AIDS were studied during 5 years in the Muñiz Hospital of Buenos Aires City. Seventy four of them presented cryptococcosis, 39 histoplasmosis and 4 both mycoses. The following specimens were studied for the diagnosis: skin and mucous membrane scrapings, bone marrow aspirations, bronchial secretions, biopsies of different organs, cerebral spinal fluid and blood cultures. Sera were also collected for serologic tests. A total of 203 samples from patients with histoplasmosis were studied, 46.3% of them

Tiroiditis de Quervain

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Idania Teresa Mora López

2015-06-01

Full Text Available Se presenta el caso de una paciente que asistió a la consulta externa de endocrinología del Hospital General Docente "Enrique Cabrera", Pinar del Río, Cuba; con 62 años de edad, de raza blanca, antecedentes de enfermedad respiratoria alta y, posteriormente, aumento de volumen en la región anterior del cuello, dolor intenso, espontáneo, disfagia, fiebre de 39ºC a 40ºC y malestar general. Se constata al examen físico un aumento de volumen difuso de la glándula tiroides y dolor a la palpación en la región anterior del cuello. Se decide darle seguimiento ambulatorio. Aspectos significativos en las investigaciones realizadas: hemograma con diferencial y eritrosedimentación; leucocitosis con desviación a la izquierda y eritrosedimentación acelerada, hormonas tiroideas y tiroestimulante normales en el inicio de la tiroiditis y elevada en meses posteriores, confirmando el diagnóstico de hipotiroidismo primario crónico.

Toward a synthetic economic systems modeling tool for sustainable exploitation of ecosystems.

Science.gov (United States)

Richardson, Colin; Courvisanos, Jerry; Crawford, John W

2011-02-01

Environmental resources that underpin the basic human needs of water, energy, and food are predicted to become in such short supply by 2050 that global security and the well-being of millions will be under threat. These natural commodities have been allowed to reach crisis levels of supply because of a failure of economic systems to sustain them. This is largely because there have been no means of integrating their exploitation into any economic model that effectively addresses ecological systemic failures in a way that provides an integrated ecological-economic tool that can monitor and evaluate market and policy targets. We review the reasons for this and recent attempts to address the problem while identifying outstanding issues. The key elements of a policy-oriented economic model that integrates ecosystem processes are described and form the basis of a proposed new synthesis approach. The approach is illustrated by an indicative case study that develops a simple model for rainfed and irrigated food production in the Murray-Darling basin of southeastern Australia. © 2011 New York Academy of Sciences.

La conversión social de Santa Mónica en una ciudad sustentable

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Guillermo Ibarra

2014-01-01

Full Text Available Santa Mónica, California, inició su transición hacia un sistema de planeación urbana sustentable a finales de la década de 1970, continuándolo hasta la actualidad. El punto de partida del fenómeno fue un movimiento ciudadano surgido en 1978, que se consolidó en 1981 como la principal fuerza política local, al obtener Por Primera vez la mayoría de los asientos en el Consejo de la Ciudad. Este trabajo analiza los factores propulsores del plan local de desarrollo sustentable en Santa Mónica. Asimismo, explica cómo se estructuró el andamiaje político que fue eficaz para traducir la negociación de los diferentes actores sociales entre los paradigmas de la competitividad urbana y el de desarrollo sustentable con justicia social. Se concluye que una ciudad sustentable es un ente social en medio de permanente conflicto y negociación, y que su éxito depende del compromiso y habilidad de los ciudadanos y las instituciones de gobierno para darles curso.

Proposed empirical gas geothermometer using multidimensional approach

Energy Technology Data Exchange (ETDEWEB)

Supranto; Sudjatmiko; Toha, Budianto; Wintolo, Djoko; Alhamid, Idrus

1996-01-24

Several formulas of surface gas geothermometer have been developed to utilize in geothermal exploration, i.e. by D'Amore and Panichi (1980) and by Darling and Talbot (1992). This paper presents an empirical gas geothermometer formula using multidimensional approach. The formula was derived from 37 selected chemical data of the 5 production wells from the Awibengkok Geothermal Volcanic Field in West Java. Seven components, i.e., gas volume percentage, CO₂, H₂S, CH₄, H₂, N₂, and NH₃, from these data are utilize to developed three model equations which represent relationship between temperature and gas compositions. These formulas are then tested by several fumarolic chemical data from Sibual-buali Area (North Sumatera) and from Ringgit Area (South Sumatera). Preliminary result indicated that gas volume percentage, H₂S and CO₂ concentrations have a significant role in term of gas geothermometer. Further verification is currently in progress.

Archivo y relato en el Río de la Plata Colonial. El difícil discurso de la violencia

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Loreley El Jaber

2013-11-01

Full Text Available La propuesta en esta ocasión es la de abordar la relación entre archivo y relato en el Río de la Plata durante el siglo XVI y, para esto, se analizará una información levantada por Cabeza de Vaca en su defensa, fechada en 1544, porque en ella se da lugar a la aparición de un conjunto de voces de españoles que denuncian los atropellos, gravámenes y “vejaciones” sufridas por parte de sus pares en procura de la cobranza del quinto. Estos discursos, no reproducidos por otros textos impresos durante el mencionado siglo, plantean una problemática compleja: la relación entre ley, violencia y espacio conquistado; pero también, otra de distinto orden: los alcances y efectos de discursividades como estas, devenires de un relato cruel detenido en el tiempo del archivo judicial. El presente trabajo busca abordar ambas problemáticas así como darle un lugar a esta serie de voces olvidadas.

Non-stationary covariance function modelling in 2D least-squares collocation

Science.gov (United States)

Darbeheshti, N.; Featherstone, W. E.

2009-06-01

Standard least-squares collocation (LSC) assumes 2D stationarity and 3D isotropy, and relies on a covariance function to account for spatial dependence in the observed data. However, the assumption that the spatial dependence is constant throughout the region of interest may sometimes be violated. Assuming a stationary covariance structure can result in over-smoothing of, e.g., the gravity field in mountains and under-smoothing in great plains. We introduce the kernel convolution method from spatial statistics for non-stationary covariance structures, and demonstrate its advantage for dealing with non-stationarity in geodetic data. We then compared stationary and non- stationary covariance functions in 2D LSC to the empirical example of gravity anomaly interpolation near the Darling Fault, Western Australia, where the field is anisotropic and non-stationary. The results with non-stationary covariance functions are better than standard LSC in terms of formal errors and cross-validation against data not used in the interpolation, demonstrating that the use of non-stationary covariance functions can improve upon standard (stationary) LSC.

COMUNICAÇÃO MÃE-FILHO DURANTE AMAMENTAÇÃO NATURAL E ARTIFICIAL NA ERA AIDS

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Simone Gonçalves Vasconcelos

2010-01-01

Full Text Available La lactancia natural de la madre infectada por el VIH al hijo es factor de riesgo para la transmisión del virus, por lo tanto se recomienda excluir la lactancia natural. El hecho de no darle el pecho puede dificultar la comunicación del binomio madre-hijo. Fue desarrollado un estudio comparativo a la luz de los factores proxémicos entre madre e hijo durante la alimentación artificial y lactancia materna entre madres seropositivas y seronegativas para el VIH. En alojamiento conjunto fueron analizadas 84 interacciones entre cuatro binomios. La distancia íntima prevalece en el 100% de las interacciones, así como la postura sentada. Los bebés de las madres seropositivas permanecieron la mayor parte del tiempo activos en comparación a los verticalmente expuestos. Probablemente, la calidad de las interacciones a lo largo del tiempo y la responsividad materna al bebé irán determinar los efectos de la falta de lactancia natural en el desarrollo del apego entre madre e hijo.

Normality test for determining the correction factor of isotopic composition in PWR spent fuel

International Nuclear Information System (INIS)

Lee, Y. H.; Shin, H. S.; Noh, S. K.; Seo, K. S.

2001-01-01

Normality test has been carried out for the ratios of the measured-to-calculated isotopic compositions in PWR spent fuel, using Shapiro-Wilk W, Lilliefors D, Cramer-von Mises and Anderson-Darling. All 38 istopices have been evaluated by means of the 1.5xIQR rule and then outliers have been discarded. As result, it seems that only 20 nuclides are satisfied with the normality at significance level 5 %. 18 Nuclides(samples) including U-235 have higher significance probability(p-value) than 25 % in W-test and p-values obtained by other three tests exceed the upper limit. Besides, in 6 nuclides including Pu-239, it seems that the p-values are between 5 % and 25 % in W test. From these results, in order to predict the isotopic compositions in the conservative point of view, it is decided that the correction factors for the nuclides are determined at the 95/95 probability and confidence level by using tolerance limit-methods with the assumption that only 18 nuclides are satisfied with thr normality

Los pobres sujetos de pobreza : Iglesia, sociedad, caridad cristiana y beneficiencia estatal en el siglo XIX

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José Domínguez San Martín

2004-01-01

Full Text Available En la primera mitad del siglo XIX hay una evolución a la respuesta del problema que plantea la pobreza y la ingente masa de pobres, que ya se viene produciendo, sobre todo, desde el siglo XVI. Es el paso de una caridad Cristiana a una beneficiencia estatal acentuado y agudizado por la secularización de la sociedad, la desamortización, las guerras, etc.. A ello hay que darle respuestas, que antes eran dadas, prioritariamente, por y desde la Iglesia y que ahora las acaparará el Estado.In the first haif of 19" centurythe response ti the probiem of poverty and the immense amount of impoverished people evolved. The increa in povery has beeen progressively growing, especially since the 1st century. It is the transition from christiam charity to State assistance, supported by the secularization ofsociety, the sale of church lands, wars, etc.. To this answers had to be given by the State that were previorisly given by the church.

Antonio Gramsci: el consejo de fábrica, germen de la sociedad futura

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Martín Prestía

2015-06-01

Full Text Available El propósito general del presente trabajo es realizar una reflexión y problematización en torno de la concepción de Antonio Gramsci del “consejo de fábrica” desde tres dimensiones que se vinculan orgánicamente: el consejo de fábrica en tanto forma político-organizativa; la problemática de la escisión entre hombre y ciudadano propia de la modernidad y la resolución que, a partir del consejo, es posible darle; y, por último, el consejo de fábrica como instancia a partir de la cual es posible construir un orden alternativo, prefigurando la sociedad de nuevo tipo. A modo de conclusión, se incluye una recapitulación de las principales claves interpretativas utilizadas en el análisis de los desarrollos gramscianos, a la vez que se propone la identificación de algunas tensiones hacia el interior de la propia argumentación del militante sardo.

Deliberate introduction of the European rabbit, Oryctolagus cuniculus, into Australia.

Science.gov (United States)

Fenner, F

2010-04-01

The European rabbit was brought to Australia as a companion animal by early settlers. It sometimes escaped, but failed to survive in the Australian bush. In 1879 wild rabbits were deliberately sent to Victoria to provide game for wealthy settlers to shoot. They soon spread all over Australia, except in the tropics, and became Australia's major animal pest. After careful testing in Australian wildlife and in humans, control by myxoma virus was introduced at various sites between 1937 and 1950, spreading all over the Murray-Darling Basin in 1950. Within one year mutations in the virus had led to slightly less virulence, and these continued for the next 50 years. In the early 21st Century testing viruses obtained from wild rabbits showed that the majority of these viruses were more virulent than the virus used to initiate the epidemic. In 1995 another virus specific for European rabbits, rabbit haemorrhagic disease virus, escaped from areas in which field trials were being carried out and spread around Australia. It was more successful than myxomatosis for rabbit control in arid regions.

Atmospheric pollutants in alpine peat bogs record a detailed chronology of industrial and agricultural development on the Australian continent

International Nuclear Information System (INIS)

Marx, Samuel K.; Kamber, Balz S.; McGowan, Hamish A.; Zawadzki, Atun

2010-01-01

Two peat bogs from remote alpine sites in Australia were found to contain detailed and coherent histories of atmospheric metal pollution for Pb, Zn, Cu, Mo, Ag, As, Cd, Sb, Zn, In, Cr, Ni, Tl and V. Dramatic increases in metal deposition in the post-1850 AD portion of the cores coincide with the onset of mining in Australia. Using both Pb isotopes and metals, pollutants were ascribed to the main atmospheric pollution emitting sources in Australia, namely mining and smelting, coal combustion and agriculture. Results imply mining and metal production are the major source of atmospheric metal pollution, although coal combustion may account for up to 30% of metal pollutants. A novel finding of this study is the increase in the otherwise near-constant Y/Ho ratio after 1900 AD. We link this change to widespread and increased application of marine phosphate fertiliser in Australia's main agricultural area (the Murray Darling Basin). - Detailed records of atmospheric metal pollution accumulation in Australia are presented and are shown to trace the industrial and agricultural development of the continent.

Diferencia racial en docentes de educación básica de Tijuana y Tecate. Un estudio exploratorio

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Jesús Aguilar Nery

2012-01-01

Full Text Available ¿En qué datos se fundamenta la idea generalizada de que existen razas humanas? Sabemos que en disciplinas como la biología y la antropología raza humana es un concepto rechazado. El propósito de este trabajo es conocer algunos de los elementos que nutren los pensamientos en torno al racismo de una muestra de profesionales de la educación básica de la franja fronteriza mexicana. Mediante un cuestionario aplicado en Tijuana y Tecate, encontramos que el concepto de raza se usa para agrupar y dividir grupos humanos. Los componentes que destacan en las definiciones son principalmente las características físicas de las personas. Concluyo señalando algunas implicaciones acerca de tener una deficiente base de conocimientos para construir una ideología racista, la cual se apoya tanto en un mecanismo cognitivo que ordena de cierto modo las diferencias, como en el procedimiento que se utiliza para darle contenido a tales diferencias.

Estimación y análisis de precios nodales como efecto de las restricciones de transmisión en el mercado mayorista de Colombia

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Luis Eduardo Gallego Vega

2010-09-01

Full Text Available El presente artículo presenta los resultados de una investigación sobre la estimación y análisis de precios nodales para el sistema de transmisión nacional de Colombia, como una alternativa para analizar el efecto de las restricciones de transmisión en el mercado mayorista de Colombia. Esta alternativa se plantea contra el modelo actual del mercado mayorista, el cual consiste en un modelo uninodal del sistema, sin darle un tratamiento adecuado a las restricciones de transmisión. La investigación describe el modelamiento del sistema de transmisión nacional, el modelamiento de la operación del despacho económico en el país y una metodología de refinamiento que incluye tanto las restricciones eléctricas como operativas del sistema. Como resultados se presenta un análisis de los precios nodales obtenidos para cada área operativa del sistema de transmisión colombiano y un análisis sobre las rentas de congestión del sistema.

Presentación del Libro “Tres Médicos Árabes” Rhases, Averroes, Avicena

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Efraim Otero Ruiz

2007-12-01

Pero esa misma migratoriedad, especialmente de las del norte, hizo que gradualmente se extendieran por Siria, Mesopotamia y por todo el antiguo imperio Persa hasta la India, por el oriente; y por Egipto y la costa norte del Africa hasta Gibraltar, por el occidente. Unidos por lenguajes ancestrales derivados del sumerio, el babilonio, el sánscrito y el urdu, que dieron origen al idioma árabe, en esas regiones había enclaves de muchas tribus y muchas religiones, mono y politeístas. El genio de Mahoma y su Corán fue el unificarlos monoteísticamente y darles un sentido de trascendencia, en esta vida y en la otra. Por eso, en el milenio que nos ocupa, se cumplió lo que después describiría maravillosamente Carlyle, el pensador inglés: Aquella estirpe, polvo inflamable por mucho tiempo aislado en el desierto, de golpe prendió fuego y sus llamas formidables se elevaron al cielo desde Dehli, en la India, hasta Granada en España...

Análisis de la adquisición del fonema /r/ en español por aprendices estadounidenses desde la fonética auditiva y articulatoria

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Pérez López, José María

2011-06-01

Full Text Available Suplemento del número 12 de marcoELE (enero - junio de 2011 El fonema /r/ es uno de los fonemas españoles que crea mayor dificultad en los aprendices de ELE por hablantes de lengua inglesa. Esta memoria plantea la hipótesis de que la máxima dificultad en la pronunciación de la [r] por parte de estudiantes universitarios estadounidenses estriba en la combinación del fonema /r/ con las consonantes oclusivas /t/ y /d/, en combinación con las cinco vocales y cuando la /r/ aparece en posición intervocálica. También especifica que la concienciación por parte del alumno es un factor primordial en el proceso de adquisición de este fonema. Por último pretende darle a la pronunciación y a la fonética el lugar que les corresponde en el proceso de enseñanza-aprendizaje de español así como una mayor presencia en los planes curriculares.

Aspiraciones y conocimientos: ¿cómo explicar que la innovación educativa resulte decepcionante? El caso de la comprensión lectora

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Emilio Sánchez Miguel

2016-06-01

Full Text Available En estas páginas tratamos de aclarar por qué tenemos tantas dificultades para dar un tratamiento adecuado a la lectura y a la comprensión de textos en el aula. Tenemos un volumen importante de conocimientos sobre qué, cómo y cuándo enseñar a comprender, pero las evidencias reunidas en diferentes paises sugieren que la implantación en las aulas de estas ideas es muy escasa. El objetivo del artículo es mostrar tres limitaciones que podrían explicar esta frustrante situación. La primera y fundamental es que no siempre se distingue entre conocimientos y aspiraciones. Una indiferenciación que afecta a nuestra visión de lo que es una lectura experta, a nuestros conocimiento sobre la vida en el aula y el papel de los profesores. Ambos problemas, repercuten decisivamente en el papel adoptado por asesores y formadores. Para aclarar estas ideas y darles un fundamento empírico, resumimos seis estudios que hemos llevado a cabo durante los últimos años.

'Doctor' or 'darling'? Decoding the communication partner from ECoG of the anterior temporal lobe during non-experimental, real-life social interaction

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Johanna eDerix

2012-09-01

Full Text Available Human brain processes underlying real-life social interaction in everyday situations have been difficult to study and have, until now, remained largely unknown. Here, we investigated whether electrocorticography (ECoG recorded for pre-neurosurgical diagnostics during the daily hospital life of epilepsy patients could provide a way to elucidate the neural correlates of non-experimental social interaction. We identified time periods in which patients were involved in conversations with either their respective life partners (Condition 1; C1 or attending physicians (Condition 2; C2. These two conditions can be expected to differentially involve subfunctions of social interaction which have been associated with activity in the anterior temporal lobe (ATL, including the temporal poles (TP. Therefore, we specifically focused on ECoG recordings from this brain region and investigated spectral power modulations in the alpha (8-12 Hz and theta (3-5 Hz frequency ranges, which have been previously assumed to play an important role in the processing of social interaction. We hypothesized that brain activity in this region might be sensitive to differences in the two interaction situations and tested whether these differences can be detected by single-trial decoding. Condition-specific effects in both theta and alpha bands were observed: the left and right TP exclusively showed increased power in C1 compared to C2, whereas more posterior parts of the ATL exhibited similar (C1 > C2 and also contrary (C2 > C1 effects. Single-trial decoding accuracies for classification of these effects were highly above chance. Our findings demonstrate that it is possible to study the neural correlates of human social interaction in non-experimental conditions. Decoding the identity of the communication partner and adjusting the speech output accordingly may be useful in the emerging field of brain- machine interfacing for restoration of expressive speech.

Ege bölgesi standart süreli yıllık maksimum yağışları için en uygun dağılımlar

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Halil Karahan

2013-03-01

Full Text Available Su kaynaklarının temel girdisi olan yağışların; miktarı, süresi, şiddeti, alansal ve zamansal değişimi v.b. özelliklerinin bilinmesi; su kaynakları, tarım, kentleşme, drenaj, taşkın kontrolü ve ulaşım gibi farklı sektörlere ait planlama, tasarım, inşaat ve işletme çalışmaları için gereklidir. Belirtilen faaliyetlerin gerçekleştirilebilmesi için; mevcut gözlemlere dayalı, güvenilir ve gerçekçi tahminlerin yapılması gerekir. Güvenilir tahmin yapabilmenin ilk aşaması ise mevcut gözlemlerin güvenirliğinin test edilmesidir. Bu çalışmada; DMİ Genel Müdürlüğü tarafından işletilen Ege Bölgesi il ve ilçe merkezlerinde yer alan meteoroloji istasyonlarında (1929-2005 yıllarında ölçülen standart süreli maksimum yağış değerlerinin hangi dağılıma uyduklarını belirlemek için; Kolmogorov-Smirnov, Anderson-Darling ve Ki-Kare dağılım uygunluk testleri uygulanmıştır. Anderson-Darling testine göre gözlemlerin tümüne yakını GEV dağılımına uyum gösterirken, Kolmogorov-Smirnov ve Ki-Kare testlerine göre kısa, orta ve uzun süreli yağış gözlemleri için genellikle GEV, Gamma ve Log-Normal dağılımın uygun olduğu görülmüştür. Seçilen olasılık dağılımının parametrelerini belirlemek için farklı dağılımlara göre maksimum olabilirlik (LN2, LN3, EXP2, Gamma3, olasılık-ağırlıklı momentler (LP3,Gamma2, L-momentler (GEV ve en küçük kareler (Weibull2 yöntemleri kullanılmıştır.

Five hydrologic and landscape databases for selected National Wildlife Refuges in the Southeastern United States

Science.gov (United States)

Buell, Gary R.; Gurley, Laura N.; Calhoun, Daniel L.; Hunt, Alexandria M.

2017-06-12

This report serves as metadata and a user guide for five out of six hydrologic and landscape databases developed by the U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, to describe data-collection, data-reduction, and data-analysis methods used to construct the databases and provides statistical and graphical descriptions of the databases. Six hydrologic and landscape databases were developed: (1) the Cache River and White River National Wildlife Refuges (NWRs) and contributing watersheds in Arkansas, Missouri, and Oklahoma, (2) the Cahaba River NWR and contributing watersheds in Alabama, (3) the Caloosahatchee and J.N. “Ding” Darling NWRs and contributing watersheds in Florida, (4) the Clarks River NWR and contributing watersheds in Kentucky, Tennessee, and Mississippi, (5) the Lower Suwannee NWR and contributing watersheds in Georgia and Florida, and (6) the Okefenokee NWR and contributing watersheds in Georgia and Florida. Each database is composed of a set of ASCII files, Microsoft Access files, and Microsoft Excel files. The databases were developed as an assessment and evaluation tool for use in examining NWR-specific hydrologic patterns and trends as related to water availability and water quality for NWR ecosystems, habitats, and target species. The databases include hydrologic time-series data, summary statistics on landscape and hydrologic time-series data, and hydroecological metrics that can be used to assess NWR hydrologic conditions and the availability of aquatic and riparian habitat. Landscape data that describe the NWR physiographic setting and the locations of hydrologic data-collection stations were compiled and mapped. Categories of landscape data include land cover, soil hydrologic characteristics, physiographic features, geographic and hydrographic boundaries, hydrographic features, and regional runoff estimates. The geographic extent of each database covers an area within which human activities, climatic

Tuber indicum shapes the microbial communities of ectomycorhizosphere soil and ectomycorrhizae of an indigenous tree (Pinus armandii.

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Qiang Li

Full Text Available The aim of this study was to investigate the effect of an ectomycorrhizal fungus (Tuber indicum on the diversity of microbial communities associated with an indigenous tree, Pinus armandii, and the microbial communities in the surrounding ectomycorhizosphere soil. High-throughput sequencing was used to analyze the richness of microbial communities in the roots or rhizosphere of treatments with or without ectomycorrhizae. The results indicated that the bacterial diversity of ectomycorhizosphere soil was significantly lower compared with the control soil. Presumably, the dominance of truffle mycelia in ectomycorhizosphere soil (80.91% and ectomycorrhizae (97.64% was the main factor that resulted in lower diversity and abundance of endophytic pathogenic fungi, including Fusarium, Monographella, Ustilago and Rhizopus and other competitive mycorrhizal fungi, such as Amanita, Lactarius and Boletus. Bacterial genera Reyranena, Rhizomicrobium, Nordella, Pseudomonas and fungal genera, Cuphophyllus, Leucangium, Histoplasma were significantly more abundant in ectomycorrhizosphere soil and ectomycorrhizae. Hierarchical cluster analysis of the similarities between rhizosphere and ectomycorrhizosphere soil based on the soil properties differed significantly, indicating the mycorrhizal synthesis may have a feedback effect on soil properties. Meanwhile, some soil properties were significantly correlated with bacterial and fungal diversity in the rhizosphere or root tips. Overall, this work illustrates the interactive network that exists among ectomycorrhizal fungi, soil properties and microbial communities associated with the host plant and furthers our understanding of the ecology and cultivation of T. indicum.

Fungemia in a university hospital: an epidemiological approach Fungemia em hospital universitário: uma abordagem epidemiológica

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Fabíola Maria Marques do Couto

2011-12-01

Full Text Available INTRODUCTION: Fungemia corresponds to the isolation of fungi in the bloodstream and occurs mostly in immunosuppressed patients. The early diagnosis and treatment of these infections are relevant given the serious threat to the affected patients and possible spread to other organs, often becoming fatal. The growing number of fungemia associated with poor prognosis resulted in this research aiming to diagnose and assess the epidemiological aspects of hematogenous infections by fungi. METHODS: The study included 58 blood samples collected within a 1-year period, from patients at the Hospital das Clinicas, Federal University of Pernambuco, by venipuncture in vacuum tubes. Blood samples were processed for direct examination and culture and identification, conducted by observing the macroscopic and microscopic characteristics, as well as physiological characteristics when necessary. RESULTS: Eight (13.8% episodes of fungemia were identified, accounting for the total sample, and these pathogens were Candida, Histoplasma, Trichosporon, Cryptococcus, and a dematiaceous fungus. C. albicans was the prevalent species, accounting for 37.5% of the cases. Most affected patients were adult males. There was no predominance for any activity, and the risk of acquired immunodeficiency syndrome was the underlying pathology most often cited. CONCLUSIONS: The isolation of fungi considered as emergent species, such as C. membranifaciens and dematiaceous species, highlights the importance of epidemiological monitoring of cases of fungemia in immunocompromised patients, as the therapy of choice depends on the knowledge of the aethiological agent.INTRODUÇÃO: Fungemia corresponde ao isolamento de fungos na corrente sanguínea e ocorre, sobretudo, em pacientes imunossuprimidos. O diagnóstico e tratamento precoce destas infecções são relevantes diante da grave ameaça aos pacientes acometidos e possível disseminação via hematogênica para outros órgãos, tornando

Foco Nasmyth para el telescopio 2,15mts. de CASLEO

Science.gov (United States)

Casagrande, A. R.

En principio, este proyecto intenta lograr el mayor aprovechamiento posible del instrumental que se dispone, buscando la manera de optimizar y hacer más eficiente el servicio que brinda el CASLEO a la comunidad astronómica. El mismo consiste en utilizar dispositivos ya existentes en el telescopio, y darle una utilidad. Tal es el caso del camino óptico destinado al foco Coude. Si tenemos en cuenta que disponemos de un tercer espejo Coude, con todos sus mecanismos automatizados, (actualmente sin uso), una distancia apropiada del plano focal, el espacio y el lugar físico necesario para instalar un periférico, es posible la habilitación de un foco Nasmyth en el telescopio 2,15mts. El hecho de contar con este nuevo foco, redundará en importantes beneficios. En primer lugar, posibilitará la observación, casi simultánea, con dos instrumentos. Otro aspecto a tener en cuenta, es que disminuirá el frecuente cambio del instrumental periférico, motivo este que degrada su ideal puesta a punto. Por último, también de interés, es de destacar su escaso costo de ejecución.

Data re-arranging techniques leading to proper variable selections in high energy physics

Science.gov (United States)

Kůs, Václav; Bouř, Petr

2017-12-01

We introduce a new data based approach to homogeneity testing and variable selection carried out in high energy physics experiments, where one of the basic tasks is to test the homogeneity of weighted samples, mainly the Monte Carlo simulations (weighted) and real data measurements (unweighted). This technique is called ’data re-arranging’ and it enables variable selection performed by means of the classical statistical homogeneity tests such as Kolmogorov-Smirnov, Anderson-Darling, or Pearson’s chi-square divergence test. P-values of our variants of homogeneity tests are investigated and the empirical verification through 46 dimensional high energy particle physics data sets is accomplished under newly proposed (equiprobable) quantile binning. Particularly, the procedure of homogeneity testing is applied to re-arranged Monte Carlo samples and real DATA sets measured at the particle accelerator Tevatron in Fermilab at DØ experiment originating from top-antitop quark pair production in two decay channels (electron, muon) with 2, 3, or 4+ jets detected. Finally, the variable selections in the electron and muon channels induced by the re-arranging procedure for homogeneity testing are provided for Tevatron top-antitop quark data sets.

A comparison of integrated river basin management strategies: A global perspective

Science.gov (United States)

Zhao, Chunhong; Wang, Pei; Zhang, Guanghong

In order to achieve the integrated river basin management in the arid and rapid developing region, the Heihe River Basin (HRB) in Northwestern China, one of critical river basins were selected as a representative example, while the Murray-Darling Basin (MDB) in Australia and the Colorado River Basin (CRB) in the USA were selected for comparative analysis in this paper. Firstly, the comparable characters and hydrological contexts of these three watersheds were introduced in this paper. Then, based on comparative studies on the river basin challenges in terms of the drought, intensive irrigation, and rapid industrialization, the hydrological background of the MDB, the CRB and the HRB was presented. Subsequently, the river management strategies were compared in three aspects: water allocation, water organizations, and water act and scientific projects. Finally, we proposed recommendations for integrated river basin management for the HRB: (1) Water allocation strategies should be based on laws and markets on the whole basin; (2) Public participation should be stressed by the channels between governance organizations and local communities; (3) Scientific research should be integrated into river management to understand the interactions between the human and nature.

Experiencias en la intervención del patrimonio industrial. Estudio comparativo

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Luz María Gilabert González

2017-01-01

Full Text Available La preservación del patrimonio arqueológico industrial, especialmente el arquitectónico, ha planteado en las últimas décadas la necesidad de darles nuevos usos para su correcta conservación. Desde este punto de vista, una de las experiencias más interesantes ha sido la reconversión de antiguos edificios industriales en museos, siendo los más abundantes por el viejo continente los denominados “de sitio” y los arqueológicos. En algunos casos, son intervenciones arquitectónicas y museográficas que han convertido a las instituciones museísticas en verdaderos centros de rehabilitación cultural y económica para su entorno urbano o rural y, de forma activa y abierta, en los motores de una creciente atracción turística de tipo cultural de esos lugares. En este artículo, se profundizará en el estudio de la Central Montemartini de Roma y el Centro Cultural Museo Hidráulico de Murcia, basándonos en tres aspectos: la historia de cada edificio, su nuevo uso y su funcionamiento como centros municipales.

en las iniciativas de Paz que construyen las bases desde lo local

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Esperanza Hernández Delgado

2002-01-01

Full Text Available El artículo destaca, desde los hallazgos de la investigación para la paz, los significados y alcances propios que comunidades indígenas, negras y campesinas, han dado a la paz y la no violencia en Colombia. Estas comunidades, no conocían la propuesta pacifista de Gandhi, Matin Luther King o Mandela, y sin embargo, desde sus necesidades y procesos propios, han generado, apropiado y jalonado, en forma perfectible, iniciativas de paz desde la base, en las que la paz ha sido concebida como defensa de la vida, resistencia civil al conflicto armado, protección de la autonomía y autodeterminación de las comunidades frente a los actores armados, participación política, desarrollo desde las bases, profundización de la democracia y defensa de la cultura, entre otras. En igual forma, estas comunidades han demostrado que Colombia también es escenario de paz y que esta no sólo se construye desde el Estado y los actores armados, sino desde las bases, que se organizan sin recurrir a las armas, en escenarios locales, para darle significados propios.

Capital social, desarrollo y políticas públicas en Medellín, 2004-2007

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Germán Darío Valencia Agudelo

2008-06-01

Full Text Available Con base en los casos de los programas de Planeación y Presupuesto Participativo y Administración Transparente y Control Social, del plan de desarrollo de Medellín 2004-2007, el artículo presenta y analiza la relación entre capital social, desarrollo (económico y social y políticas públicas. Se muestra cómo estos dos programas constituyen acciones que ayudan a fomentar y consolidar el capital social en la ciudad. En las dos primeras partes, se cuenta cómo se ha venido incorporando el capital social en las políticas del desarrollo; en la tercera, se utilizan los resultados de 1.210 encuestas para mostrar la relación de los dos programas con la dinámica de Medellín en 2007 en términos de participación ciudadana, transparencia administrativa y confianza en el gobierno; en la parte final, se presentan algunas propuestas para fortalecer estos programas en la ciudad y se concluye que el gobierno local debe mejorar estos programas y darles continuidad debido a su capacidad para generar confianza y cooperación en la ciudad.

Capital social, desarrollo y políticas públicas en Medellín, 2004-2007

Directory of Open Access Journals (Sweden)

Germán Darío Valencia Agudelo

2008-01-01

Full Text Available Con base en los casos de los programas de Planeación y Presupuesto Participativo y Administración Transparente y Control Social, del plan de desarrollo de Medellín 2004-2007, el artículo presenta y analiza la relación entre capital social, desarrollo (económico y social y políticas públicas. Se muestra cómo estos dos programas constituyen acciones que ayudan a fomentar y consolidar el capital social en la ciudad. En las dos primeras partes, se cuenta cómo se ha venido incorporando el capital social en las políticas del desarrollo; en la tercera, se utilizan los resultados de 1.210 encuestas para mostrar la relación de los dos programas con la dinámica de Medellín en 2007 en términos de participación ciudadana, transparencia administrativa y confianza en el gobierno; en la parte final, se presentan algunas propuestas para fortalecer estos programas en la ciudad y se concluye que el gobierno local debe mejorar estos programas y darles continuidad debido a su capacidad para generar confianza y cooperación en la ciudad.

Contabilidad de costos ambientales en la industria cárnica, recomendaciones para su desarrollo

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Yunier Maresma-Hernández

2016-01-01

Full Text Available La contabilidad ambiental ha logrado darle un matiz económico y financiero al uso, cuidado y conservación del medio ambiente, convirtiéndose esta, en una valiosa herramienta para la toma de decisiones, generando beneficios tanto para las organizaciones como para el medio natural. Es por tal razón que se enfoca este trabajo al estudio de los sistemas de costos empleados por la industria cárnica; tomando como estudio de caso la Empresa Cárnica Holguín. Para la realización de la investigación se utilizaron los métodos revisión de documentos, estudio de casos, análisis y síntesis, entrevistas a especialistas contables donde se pudo esclarecer aspectos descritos en el manual de costo. Se realizó un examen a los sistemas de costos empleados y los procedimientos contables que se aplican para la distribución de los gastos y como resultado de esta investigación se dan sugerencias para la implementación de un sistema de costos ambientales en esta entidad.

Normal probability plots with confidence.

Science.gov (United States)

Chantarangsi, Wanpen; Liu, Wei; Bretz, Frank; Kiatsupaibul, Seksan; Hayter, Anthony J; Wan, Fang

2015-01-01

Normal probability plots are widely used as a statistical tool for assessing whether an observed simple random sample is drawn from a normally distributed population. The users, however, have to judge subjectively, if no objective rule is provided, whether the plotted points fall close to a straight line. In this paper, we focus on how a normal probability plot can be augmented by intervals for all the points so that, if the population distribution is normal, then all the points should fall into the corresponding intervals simultaneously with probability 1-α. These simultaneous 1-α probability intervals provide therefore an objective mean to judge whether the plotted points fall close to the straight line: the plotted points fall close to the straight line if and only if all the points fall into the corresponding intervals. The powers of several normal probability plot based (graphical) tests and the most popular nongraphical Anderson-Darling and Shapiro-Wilk tests are compared by simulation. Based on this comparison, recommendations are given in Section 3 on which graphical tests should be used in what circumstances. An example is provided to illustrate the methods. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Tipos de tirano y resistencia en Francisco Suárez

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Pablo Font Oporto

2017-09-01

Full Text Available El presente artículo pretende analizar la discusión que Francisco Suárez mantiene con las tesis contrarias a la distinción entre tipos de tirano en la cuestión del tiranicidio (Defensio fidei, Libro VI, capítulo IV, números 10-13. Para esta visión no le es lícito a una persona privada matar a ninguno de los dos tipos de tirano; sólo es posible darles muerte en legítima defensa, porque se entiende que en tal caso se actúa en ejercicio de autoridad pública. Suárez acaba admitiendo esta tesis en el número 13, lo que parece contradecirse con lo sostenido en el número 7, donde se aceptaba la muerte del usurpador por cualquier particular. Sin embargo, en el fondo mantiene la diferencia entre ambos tipos de tirano, por cuanto que en el caso del usurpador sostiene que siempre se dan las condiciones para alegar legítima defensa. Queda sin aclarar qué ocurre en tal caso con las condiciones dispuestas en los números 8 y 9.

Bayesian inference method for stochastic damage accumulation modeling

International Nuclear Information System (INIS)

Jiang, Xiaomo; Yuan, Yong; Liu, Xian

2013-01-01

Damage accumulation based reliability model plays an increasingly important role in successful realization of condition based maintenance for complicated engineering systems. This paper developed a Bayesian framework to establish stochastic damage accumulation model from historical inspection data, considering data uncertainty. Proportional hazards modeling technique is developed to model the nonlinear effect of multiple influencing factors on system reliability. Different from other hazard modeling techniques such as normal linear regression model, the approach does not require any distribution assumption for the hazard model, and can be applied for a wide variety of distribution models. A Bayesian network is created to represent the nonlinear proportional hazards models and to estimate model parameters by Bayesian inference with Markov Chain Monte Carlo simulation. Both qualitative and quantitative approaches are developed to assess the validity of the established damage accumulation model. Anderson–Darling goodness-of-fit test is employed to perform the normality test, and Box–Cox transformation approach is utilized to convert the non-normality data into normal distribution for hypothesis testing in quantitative model validation. The methodology is illustrated with the seepage data collected from real-world subway tunnels.

Reading baby books: medicine, marketing, money and the lives of American infants.

Science.gov (United States)

Golden, Janet; Weiner, Lynn

2011-01-01

This article examines American baby books from the late nineteenth through the twentieth century. Baby books are ephemeral publications—formatted with one or more printed pages for recording developmental, health, and social information about infants and often including personal observations, artifacts such as photographs or palm prints, medical and other prescriptive advice, and advertisements. For historians they serve as records of the changing social and cultural worlds of infancy, offering insights into the interplay of childrearing practices and larger social movements.Baby books are a significant historical source both challenging and supporting current historiography, and they illustrate how medical, market and cultural forces shaped the ways babies were cared for and in turn how their won behavior shaped family lives. A typology of baby books includes the lavishly illustrated keepsake books of the late nineteenth century, commercial and public health books of the twentieth century, and on-line records of the present day. Themes that emerge over time include those of scientific medicine and infant psychology, religion and consumerism. The article relies on secondary literature and on archival sources including the collections of the UCLA Louise M. Darling Biomedical Library as well as privately held baby books.

UN PRIVILEGIO PARA EL ESTADO DE MICHOACÁN: SUS PUEBLOS MÁGICOS

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Horacio Mercado Vargas

2013-06-01

Full Text Available El Estado de Michoacán, que se ubica en la parte del extremo sur occidental de México, posee paisajes muy hermosos: de bosques, praderas y lagunas de gran belleza, montañas y volcanes que descienden hacia el mar. Es uno de los más ricos en recursos naturales. La Secretaría de Turismo, diversas entidades del gobierno federal y gobiernos estatales y municipales desarrollaron el Programa de Pueblos Mágicos, para darle un valor a ciertas poblaciones del país que tienen características culturales y que llaman la atención de los visitantes mexicanos y extranjeros. Michoacán es una entidad que por sus características culturales, se distingue del resto de las entidades, y por ello es el estado con mayor número de Pueblos Mágicos en todo el país. La belleza y cultura de Michoacán se puede constatar en sus Pueblos Mágicos, que siempre recordarán los visitantes. Sus formas, colores y tradiciones son expresiones de un pasado lleno de gloria que se manifiesta en el presente.

Entrevista con Patricia Ariza

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Esperanza Londoño La Rotta

2017-01-01

Full Text Available Pensamiento, Palabra y Obra entrevista a una artista, feminista y activista política, quien como mujer y artista ha permitido pensar el arte más allá de un simple espectáculo. Toda una vida dedicada al teatro y a darle voz, a través de sus obras, a víctimas del conflicto colombiano, defensora de derechos humanos; además de hacer evidente en su vida y a través de la plataforma “Artistas por la paz”, las múltiples relaciones que se pueden establecer entre el arte, la construcción de paz y la resolución de conflictos. Hablamos en su casa, en medio del calor de la bienvenida con Patricia Ariza, directora del festival alternativo de teatro, de Mujeres en Escena y de la Corporación Colombiana de Teatro, entre otras muchas actividades que voluntariamente su espíritu libertario ha asumido. Esta entrevista se realizó antes del 2 de octubre, pero con la revisión de los acuerdos que propició el plebiscito ganado por una ínfima minoría por el no, sigue siendo vigente este planteamiento.

Last glacial megafaunal death assemblage and early human occupation at Lake Menindee, southeastern Australia

Science.gov (United States)

Cupper, Matthew L.; Duncan, Jacqui

2006-09-01

The Tedford subfossil locality at Lake Menindee preserves a diverse assemblage of marsupials, monotremes and placental rodents. Of the 38 mammal taxa recorded at the site, almost a third are of extinct megafauna. Some of the bones are articulated or semi-articulated and include almost complete skeletons, indicating that aeolian sediments rapidly buried the animals following death. New optical ages show the site dates to the early part of the last glacial (55,700 ± 1300 yr weighted mean age). This is close to the 51,200-39,800 yr Australia-wide extinction age for megafauna suggested by Roberts et al. [2001, Science 292:1888-1892], but like all previous researchers, we cannot conclusively determine whether humans were implicated in the deaths of the animals. Although an intrusive hearth at the site dating to 45,100 ± 1400 yr ago is the oldest evidence of human occupation of the Darling River, no artifacts were identified in situ within the sub-fossil-bearing unit. Non-anthropogenic causes, such as natural senescence or ecosystem stress due to climatic aridity, probably explain the mortality of the faunal assemblage at Lake Menindee.

Near field plasmonic gradient effects on high vacuum tip-enhanced Raman spectroscopy.

Science.gov (United States)

Fang, Yurui; Zhang, Zhenglong; Chen, Li; Sun, Mengtao

2015-01-14

Near field gradient effects in high vacuum tip-enhanced Raman spectroscopy (HV-TERS) are a recent developing ultra-sensitive optical and spectral analysis technology on the nanoscale, based on the plasmons and plasmonic gradient enhancement in the near field and under high vacuum. HV-TERS can not only be used to detect ultra-sensitive Raman spectra enhanced by surface plasmon, but also to detect clear molecular IR-active modes enhanced by strongly plasmonic gradient. Furthermore, the molecular overtone modes and combinational modes can also be experimentally measured, where the Fermi resonance and Darling-Dennison resonance were successfully observed in HV-TERS. Theoretical calculations using electromagnetic field theory firmly supported experimental observation. The intensity ratio of the plasmon gradient term over the linear plasmon term can reach values greater than 1. Theoretical calculations also revealed that with the increase in gap distance between tip and substrate, the decrease in the plasmon gradient was more significant than the decrease in plasmon intensity, which is the reason that the gradient Raman can be only observed in the near field. Recent experimental results of near field gradient effects on HV-TERS were summarized, following the section of the theoretical analysis.

Numerical-analytic implementation of the higher-order canonical Van Vleck perturbation theory for the interpretation of medium-sized molecule vibrational spectra.

Science.gov (United States)

Krasnoshchekov, Sergey V; Isayeva, Elena V; Stepanov, Nikolay F

2012-04-12

Anharmonic vibrational states of semirigid polyatomic molecules are often studied using the second-order vibrational perturbation theory (VPT2). For efficient higher-order analysis, an approach based on the canonical Van Vleck perturbation theory (CVPT), the Watson Hamiltonian and operators of creation and annihilation of vibrational quanta is employed. This method allows analysis of the convergence of perturbation theory and solves a number of theoretical problems of VPT2, e.g., yields anharmonic constants y(ijk), z(ijkl), and allows the reliable evaluation of vibrational IR and Raman anharmonic intensities in the presence of resonances. Darling-Dennison and higher-order resonance coupling coefficients can be reliably evaluated as well. The method is illustrated on classic molecules: water and formaldehyde. A number of theoretical conclusions results, including the necessity of using sextic force field in the fourth order (CVPT4) and the nearly vanishing CVPT4 contributions for bending and wagging modes. The coefficients of perturbative Dunham-type Hamiltonians in high-orders of CVPT are found to conform to the rules of equality at different orders as earlier proven analytically for diatomic molecules. The method can serve as a good substitution of the more traditional VPT2.

La presencia y representación de la mujer científica en la prensa española

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E Aladro Vico

2014-02-01

Full Text Available Introducción: Este proyecto de investigación y desarrollo parte de la hipótesis de que las mujeres científicas son invisibles en los medios españoles. Objetivos y metodología: Para comprobar si esto es así en la prensa y cuál es la imagen de la mujer que se ofrece, analizamos la información científica difundida por los cinco principales diarios generalistas de pago durante seis meses no consecutivos. Conclusiones: Los resultados revelan que estos diarios dedican únicamente el 2,6% de sus páginas a información sobre ciencia y que, dentro de éstas, la mujer protagoniza el 14,3% de los artículos frente al 70,6%, que se centra en los hombres, y el 15%, que atiende a ambos. La representación que se hace de la mujer en estas informaciones relata sus investigaciones sin darle protagonismo y de forma aséptica, con ausencia de adjetivos valorativos. Encontramos así una importante desigualdad en el tratamiento informativo de los científicos y las científicas en España.

Propuesta de multimedia alternativa para la superación de entrenadores, primera categoría de la Federación Chilena de Boxeo. Su fundamento metodológico, la dirección técnico – táctica

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Lázaro A. Pastor Chirino

2007-03-01

Full Text Available Las experiencias de la presente investigación permiten establecer el criterio de la necesidad de introducir con la mayor brevedad posible los adelantos tecnológicos en función de una mayor eficiencia tanto en conocimiento de entrenadores y especialistas como en el cumplimiento de los principales objetivos de la preparación de los boxeadores (su alcance: la preparación Técnico-Táctica. La elaboración de este software en el que se combina de forma coherente la interconexión entre las principales direcciones funcionales y la dirección Técnica–Táctica, permite viabilizar el proceso de entrenamiento poniendo en mano del entrenador una herramienta de un importante valor para su constante explotación y perfeccionamiento. En el trabajo se arriban a importantes conclusiones sobre como interactuar con este adelanto tecnológico con recomendaciones precisas de cómo enriquecer y hacer más dinámico el proceso de entrenamiento apoyado en la aplicación de importantes métodos investigativos para darle cumplimiento de forma racional a los objetivos, tareas y preguntas plasmadas en la investigación.

Intervención\tcomunitaria\tcon\tla\ttécnica\tdel\t“ORIGAMI”\ten la ESBU “Ceferino Fernández Viñas” del municipio de Pinar del Río

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Sergio Abel Suárez García

2009-12-01

Full Text Available En nuestro trabajo pretendemos proponer una metodología para la enseñanza del “Origami”, como técnica que pueda ser usada por los docentes en los centro educacionales de la provincia, representando como algo de gran utilidad y que se complementa con la técnica de los audiovisuales que generan pasividad en los estudiantes; es una manera de favorecer el desarrollo integral, entiéndase cognitivo, emocional, físico, además de modificar conductas inadecuadas y mejorar los comportamientos en los centros educacionales y la comunidad. El uso de los materiales que son utilizados en la elaboración del medio, son materiales recuperados de fácil adquisición, logrando con ellos darle riendas sueltas al pensamiento creativo de los estudiantes, obteniendo unidad entre ciencia, arte y ejercicios manuales; podemos además con ellos embellecer nuestro entorno, ambiente y considerarse admirados por lo que hemos creado, contribuyendo con esta técnica a la armonía general del estudiante y de quienes comparten con ellos la dinámica y convivencia en los centros educacionales.

e- Learning approach in cathedra CORHUILA: Pedagogical Experience

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Eilin Lorena Pérez Montero

2015-12-01

Full Text Available Rev.esc.adm.neg La convergencia de las Tecnologías de la Información y comunicación (TIC, como mediador didáctico, ha construido rutas de aprendizaje creando ambientes que permiten desarrollar un pensamiento creativo, participativo, haciendo la educación más accesible y dinámica. En concordancia con la anterior reflexión, la Corporación Universitaria del Huila (CORHUILA, dentro de las necesidades de adoptar la tecnología y de darle herramientas a los docentes y estudiantes para su quehacer pedagógico, busca potenciar espacios donde confluyan procesos didácticos junto con la intermediación de dichas Tecnologías. De esta manera, el presente escrito es una aproximación de la experiencia pedagógica de la asignatura Cátedra CORHUILA bajo la modalidad e-learning orientada en todos los programas académicos de la Institución en el periodo académico B-2014 con el objetivo de señalar algunas recomendaciones y criterios a tener en cuenta para beneficiar en el desarrollo del conocimiento.

Satellite Remote Sensing For Aluminum And Nickel Laterites

Science.gov (United States)

Henderson, Frederick B.; Penfield, Glen T.; Grubbs, Donald K.

1984-08-01

The new LANDSAT-4,-5/Thematic Mapper (TM) land observational satellite remote sensing systems are providing dramatically new and important short wave infrared (SWIR) data, which combined with Landsat's Multi-Spectral Scanner (MSS) visible (VIS), very near infrared (VNIR), and thermal infrared (TI) data greatly improves regional geological mapping on a global scale. The TM will significantly improve clay, iron oxide, aluminum, and nickel laterite mapping capabilities over large areas of the world. It will also improve the ability to discriminate vegetation stress and species distribution associated with lateritic environments. Nickel laterites on Gag Island, Indonesia are defined by MSS imagery. Satellite imagery of the Cape Bougainville and the Darling Range, Australia bauxite deposits show the potential use of MSS data for exploration and mining applications. Examples of satellite syn-thetic aperture radar (SAR) for Jamaica document the use of this method for bauxite exploration. Thematic Mapper data will be combined with the French SPOT satellite's high spatial resolution and stereoscopic digital data, and U.S., Japanese, European, and Canadian Synthetic Aperture Radar (SAR) data to assist with logistics, mine development, and environ-mental concerns associated with aluminum and nickel lateritic deposits worldwide.

Optimal dynamic water allocation: Irrigation extractions and environmental tradeoffs in the Murray River, Australia

Science.gov (United States)

Grafton, R. Quentin; Chu, Hoang Long; Stewardson, Michael; Kompas, Tom

2011-12-01

A key challenge in managing semiarid basins, such as in the Murray-Darling in Australia, is to balance the trade-offs between the net benefits of allocating water for irrigated agriculture, and other uses, versus the costs of reduced surface flows for the environment. Typically, water planners do not have the tools to optimally and dynamically allocate water among competing uses. We address this problem by developing a general stochastic, dynamic programming model with four state variables (the drought status, the current weather, weather correlation, and current storage) and two controls (environmental release and irrigation allocation) to optimally allocate water between extractions and in situ uses. The model is calibrated to Australia's Murray River that generates: (1) a robust qualitative result that "pulse" or artificial flood events are an optimal way to deliver environmental flows over and above conveyance of base flows; (2) from 2001 to 2009 a water reallocation that would have given less to irrigated agriculture and more to environmental flows would have generated between half a billion and over 3 billion U.S. dollars in overall economic benefits; and (3) water markets increase optimal environmental releases by reducing the losses associated with reduced water diversions.

AUTOMATIZACIÓN DE OFICINAS S.A.

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Luis Carlos Diaz Osorio

1998-01-01

Full Text Available El caso muestra la situación de Automatización de Oficinas S.A., una empresa de gran trayectoria nacional, orientada a la comercialización de muebles y equipos para oficina. A principios de la década pasada, comenzó a comercializar microcomputadoras y elementos de conectividad de redes, manejando grandes márgenes por ser monopolio, aprovechando los beneficios de importación que le otorgaba el ser exportador de muebles. En el momento en que se abren las importaciones, más de doscientas empresas entran a competir en el mercado de los microcomputadores, llegando incluso a manejar márgenes de hasta el 10%. Las ventas de la empresa han bajado a niveles alarmantes, incluso se cree que únicamente compran empresas allegadas a los directivos o personas que no conocen nada del tema de los computadores. La situación puntual es la toma de decisión de las estrategias para ser competitivos o decidir salir del mercado de los PC. La orientación que hemos decidido darle al caso es “fijación de precios”.

Historia y crítica en la transformación ética de los sujetos. Michel Foucault, 1926–1984

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Alberto Castrillón

2016-01-01

Full Text Available Como reconocimiento a los aportes de Foucault a la investigación histórica, este análisis relaciona historia y crítica con la comprensión del funcionamiento de la subjetividad moderna y contemporánea, con el fin de descifrar la forma como este autor revela las matrices de subjetivación que nos constituyen como sujetos modernos. La analítica de sus obras permite entender la coherencia de su objetivo al relacionar el trabajo histórico con la comprensión minuciosa del presente, y así ubicarse en una línea de trabajo establecida por Kant. Lo cual implica entender relaciones problemáticas, como las que establecemos entre su comprensión del mundo greco-romano y la búsqueda de formas históricas de vida que permitan construir posiciones de sujeto frente a las situaciones contemporáneas de los mundos neoliberales, orientadas a darle un sentido al discurso histórico asociándolo a la búsqueda de una fundamentación ética de la existencia.

Creating institutional flexibility for adaptive water management: insights from two management agencies.

Science.gov (United States)

Peat, Michael; Moon, Katie; Dyer, Fiona; Johnson, William; Nichols, Susan J

2017-11-01

Adaptive management is an experimental approach used by water management agencies around the world to manage and restore aquatic ecosystems. The effectiveness of the approach can often be constrained by inflexible institutional arrangements. In this paper we compare two cases where agencies have implemented adaptive management to manage and restore aquatic ecosystems. Our aim was to understand practitioners' perceptions of how institutional flexibility can be created for adaptive management. We interviewed 14 adaptive management practitioners working in the Murray-Darling Basin, Australia and 14 practitioners in Southern Florida, United States of America. We found that in both cases, just enough flexibility was created to enable experimentation, but informal institutional arrangements tended to constrain adaptive management. We also found that adaptive management was effective when an agency adopted collaborative and distributed leadership, but these leadership styles were difficult to sustain, and not always appropriate when attempting to create institutional flexibility. Our results illustrate how agencies, stakeholders and researchers can develop a shared understanding of how to manage and restore aquatic ecosystems, which in turn, helps create institutional flexibility for an agency to manage adaptively. Copyright © 2017 Elsevier Ltd. All rights reserved.

¿Cómo darle visibilidad a la violencia contra las mujeres en Chile? Contribución de las Agencias de las Naciones Unidas

OpenAIRE

Jáuregui Mejía, María Luisa

2005-01-01

En este artículo se presenta el trabajo que está siendo realizado por la Mesa Temática de Género, que es un grupo de Expertas en Género de cinco Agencias de las Naciones Unidas con sede en Chile, que trabajan de forma unida dando apoyo al Servicio Nacional de la Mujer en Chile (SERNAM), para encarar el tema de la violencia contra las mujeres en Chile. El trabajo se concentra prioritariamente en tres áreas: prevención de la violencia, tratamiento de las víctimas y denuncia de...

Kapteni roll tõendite kogumisel / North East Branch of the Nautical Institute ; [tlk. Uno Laur ; toim. Viiu Suurväli ; eess.: Gerald Darling

Index Scriptorium Estoniae

1997-01-01

Kapteni osa, logiraamatud ; lasti kahjustus, kaotus ja puudujääk ; kindlustus ja laevarike ; vaegtäitmise- ja ülekulupretensioonid ; ohtlikud sadamad ja laadimispaigad ; statsionaarsete ja ujuvobjektide vigastused ; õlireostus ; üldavarii ; päästmine ; laevakokkupõrked ; töötülide lahendamine ja distsiplinaarküsimused ; õnnetusjuhtumid inimestega ; piletita reisijad , põgenikud

Kapteni roll tõendite kogumisel / North East Branch of the Nautical Institute ; [tlk. Uno Laur ; toim. Viiu Suurväli ; eess.: Gerald Darling

Index Scriptorium Estoniae

1998-01-01

Kapteni osa, logiraamatud ; lasti kahjustus, kaotus ja puudujääk ; kindlustus ja laevarike ; vaegtäitmise- ja ülekulupretensioonid ; ohtlikud sadamad ja laadimispaigad ; statsionaarsete ja ujuvobjektide vigastused ; õlireostus ; üldavarii ; päästmine ; laevakokkupõrked ; töötülide lahendamine ja distsiplinaarküsimused ; õnnetusjuhtumid inimestega ; piletita reisijad , põgenikud

Potential utility of environmental DNA for early detection of Eurasian watermilfoil (Myriophyllum spicatum)

Science.gov (United States)

Newton, Jeremy; Sepulveda, Adam; Sylvester, K; Thum, Ryan

2016-01-01

Considering the harmful and irreversible consequences of many biological invasions, early detection of an invasive species is an important step toward protecting ecosystems (Sepulveda et al. 2012). Early detection increases the probability that suppression or eradication efforts will be successful because invasive populations are small and localized (Vander Zanden et al. 2010). However, most invasive species are not detected early because current tools have low detection probabilities when target species are rare and the sampling effort required to achieve acceptable detection capabilities with current tools is seldom tractable (Jerde et al. 2011). As a result, many invasive species go undetected until they are abundant and suppression efforts become costly. Novel DNA-based surveillance tools have recently revolutionized early detection abilities using environmental DNA (eDNA) present in the water (Darling and Mahon 2011, Bohmann et al. 2014). In brief, eDNA monitoring enables the identification of organisms from DNA present and collected in water samples. Aquatic and semiaquatic organisms release DNA contained in sloughed, damaged, or partially decomposed tissue and waste products into the water and molecular techniques allow this eDNA in the water column to be identified from simple and easy-tocollect water samples (Darling and Mahon 2011). Despite limited understanding of the production, persistence, and spread of DNA in water (Barnes et al. 2014), eDNA monitoring has been applied not only to invasive species (Jerde et al. 2011), but also to species that are rare, endangered, or highly elusive (Spear et al. 2014). However, most eDNA research and monitoring has focused on detection of invertebrates and vertebrates and less attentionhas been given to developing eDNA techniques for detecting aquatic invasive plants. Eurasian watermilfoil (EWM; Myriophyllum spicatum L.) is an invasive species for which improved early detection would be particularly helpful. Advanced

Comparação entre as distribuições normal e de Weibull para análise da resistência à compressão do concreto (doi:10.5216/reec.v9i3.28814

Directory of Open Access Journals (Sweden)

Paulo Eduardo Teodoro

2014-11-01

Full Text Available RESUMO: O projeto de estruturas de concreto possui uma modelagem matemática de natureza bastante subjetiva. Portanto, objetivou-se com esta pesquisa verificar se as distribuições Normal e de Weibull podem ser aplicadas aos dados resistências à compressão do concreto pronto, agrupados comercialmente. O estudo foi realizado durante o ano de 2011 na cidade de Campo Grande/MS. A resistência à compressão foi avaliada em ensaios de 189 amostras aos 28 dias a partir de diferentes construções de concreto armado realizados na cidade. Os ensaios ocorreram conforme prescrito pela NBR 5739 (ABNT, 2007. Para quantificar o grau em que a distribuição Normal e de Weibull se ajustaram os dados experimentais foram utilizados três testes de adequação: qui-quadrado, Anderson-Darling e Kolmogorov-Smirnov. Com base no presente estudo, a distribuição Weibull pode ser aplicada aos dados de resistência à compressão para concreto. Isto sugere que, apesar de os complexos processos envolvidos na falha de compressão para um material compósito quase frágil como o concreto, um modelo de força estatística é eficaz. Além disso, ao comparar os testes de ajuste, há grande diferença prática entre as distribuições Normal e de Weibull. Esta informação é uma importante adição experimental para a literatura científica no que diz respeito à ruptura de materiais “semi-frágeis”. ABSTRACT: The design of concrete structures and their mathematical modeling is rather subjective in its nature. Therefore, it is the purpose of this study to see whether the Weibull or Normal distributions can be applied to the compressive strengths of commercially batched ready-mixed concrete. The study was conducted during the year 2011 in the city of Campo Grande / MS. The compressive strength was evaluated in 189 test samples at 28 days from different concrete constructions conducted in the city. The trials took place as prescribed by NBR 5739 (ABNT, 2007. To

Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease

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Tobias Peikert

2012-01-01

Full Text Available Fibrosing mediastinitis (FM and IgG4-related disease (IgG4-RD are two fibroinflammatory disorders with potentially overlapping clinical and radiological features. In this paper, we looked for histopathologic features of IgG4-RD and enumerated infiltrating IgG4-positive plasma cells within mediastinal tissue biopsies from FM patients. We identified 15 consecutive FM surgical mediastinal tissue biopsies between 1985 and 2006. All patients satisfied the clinical and radiological diagnostic criteria for FM. All patients had either serological or radiological evidence of prior histoplasmosis or granulomatous disease, respectively. Formalin-fixed paraffin-embedded tissue sections of all patients were stained for H&E, IgG, and IgG4. Three samples met the predefined diagnostic criteria for IgG4-RD. In addition, characteristic histopathologic changes of IgG4-RD in the absence of diagnostic numbers of tissue infiltrating IgG4-positive plasma cells were seen in a number of additional cases (storiform cell-rich fibrosis in 11 cases, lymphoplasmacytic infiltrate in 7 cases, and obliterative phlebitis/arteritis in 2 cases. We conclude that up to one-third of histoplasmosis or granulomatous-disease-associated FM cases demonstrate histopathological features of IgG4-RD spectrum. Whether these changes occur as the host immune response against Histoplasma or represent a manifestation of IgG4-RD remains to be determined. Studies to prospectively identify these cases and evaluate their therapeutic responses to glucocorticoids and/or other immunosuppressive agents such as rituximab are warranted.

Fungi that Infect Humans.

Science.gov (United States)

Köhler, Julia R; Hube, Bernhard; Puccia, Rosana; Casadevall, Arturo; Perfect, John R

2017-06-01

Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures. Morphogenesis between small round, detachable cells and long, connected cells is the mechanism by which fungi solve problems of locomotion around or through host barriers. Secretion of lytic enzymes, and uptake systems for the released nutrients, are necessary if a fungus is to nutritionally utilize human tissue. Last, the potent human immune system evolved in the interaction with potential fungal pathogens, so few fungi meet all four conditions for a healthy human host. Paradoxically, the advances of modern medicine have made millions of people newly susceptible to fungal infections by disrupting immune defenses. This article explores how different members of four fungal phyla use different strategies to fulfill the four criteria to infect humans: the Entomophthorales, the Mucorales, the Ascomycota, and the Basidiomycota. Unique traits confer human pathogenic potential on various important members of these phyla: pathogenic Onygenales comprising thermal dimorphs such as Histoplasma and Coccidioides ; the Cryptococcus spp. that infect immunocompromised as well as healthy humans; and important pathogens of immunocompromised patients- Candida , Pneumocystis , and Aspergillus spp. Also discussed are agents of neglected tropical diseases important in global health such as mycetoma and paracoccidiomycosis and common pathogens rarely implicated in serious illness such as dermatophytes. Commensalism is considered, as well as parasitism, in shaping genomes and physiological systems of hosts and fungi during evolution.

Alterações morfológicas da glândula supra-renal na síndrome da imunodeficiência adquirida

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Duch Francisco Moretti

1998-01-01

Full Text Available Na síndrome da imunodeficiência adquirida (AIDS pode-se verificar o acometimento da supra-renal por efeito citopático direto pelo HIV, por infecções oportunistas ou neoplasias. Estes achados poderiam variar de acordo com a procedência do paciente, devido às doenças peculiares à região. Neste trabalho avaliou-se o comprometimento da supra-renal em quatorze pacientes que morreram de AIDS no Hospital Escola, em Uberaba. Treze eram do sexo masculino e treze brancos. A idade foi de 29,9 ± 7,8 anos e o índice de massa corporal foi de 19 ± 4,1kg/m2. Os fragmentos de supra-renal obtidos nas necropsias foram analisados em microscópio de luz. Encontramos inflamação em 100% dos casos, identificando-se o agente etiológico em oito (58,1% casos. O Citomegalovírus foi identificado em sete casos, o Cryptococcus sp e o Herpes simplex em dois e o Histoplasma sp em um caso, estes achados são semelhantes aos da literatura. Em um caso, encontramos calcificação do parênquima e em outro, flebite da veia central. Em alguns casos que apresentavam lesão não foi possível identificar o agente etiológico, talvez em decorrência do efeito citopático direto pelo HIV ou devido a toxicidade das drogas utilizadas no tratamento da AIDS e das infecções oportunistas.

como promotores de la cultura

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Julio Julio Di Bella Roldán

2004-01-01

Full Text Available La televisión pública, por su mismo origen, es una televisión que se debe preocupar por cómo obtener una mejor calidad con un menor presupuesto en relación con las televisoras privadas. El gran reto cultural que las televisoras públicas afrontan es el de solventar sus recursos económicos para darle una viabilidad a su producción, hacerla rentable, atractiva y que cumpla con los estatutos gubernamentales de promoción a la educación y difusión de la cultura. La televisión pública debe, por los principios que la rigen, permanecer con una visión social responsable y dedicarse a las diversas áreas de la cultura de nuestro país desde una perspectiva interdisciplinaria y humanista, promoviendo contenidos de calidad. El compromiso que debe hacer la televisión pública con la audiencia es un compromiso en el ámbito nacional, llevando una cruzada junto con la Universidad Pública, por la libertad de pensamiento que conlleva una responsabilidad. La Universidad Pública y la televisión pública son, entonces, medios idóneos para la promoción de las expresiones del pensamiento y la cultura de nuestro país.

Elaboración y caracterización fisicoquímica de un vino joven de fruta de borojó (B patinoi Cuatrec

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Luis Alberto García Zapateiro

2016-01-01

Full Text Available El objetivo principal de esta investigación fue la elaboración y caracterización fisicoquímica y microbiológica de un vino joven de fruta a partir de Borojó (Borojoa patinoi Cuatrec, para el aprovechamiento de esta fruta exótica del Pacifico colombiano. Se elaboró un vino joven de borojó a partir del mosto fermentable, se realizaron los procesos de clarificación y filtración para darle brillo y acabado al vino final. La caracterización fisicoquímica presentó un contenido de 9.25 grado alcoholímetricos, dentro de los parámetros establecidos. Los valores cifrados como mínimos y máximos fueron tomados de la Norma Técnica Colombiana 708 (ntc 708. Bebidas Alcohólicas vinos de frutas y fueron de aceptación para vino de frutas que cumple con lo establecido en el decreto 1686 de 2012 de la legislación vigente de bebidas alcohólicas. Los resultados de los análisis microbiológicos estuvieron dentro de los rangos permitidos para la pulpa de borojó y el vino joven obtenido.

Contribuciones a la técnica de la prostatectomía suprapúbica

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Fabio Murillo Rivera

1949-01-01

Full Text Available En el panorama quirúrgico de la Urología domina el problema de la obstrucción prostática y hacia él se han dirigido la mayoría de las inquietudes de todo cirujano que transita en este delicado campo; su máxima aspiración es rodear al paciente de las mejores condiciones para realizar el acto operatorio, proporcionar la mayor seguridad para su vida durante aquél, empleando la técnica más apropiada a su caso particular, darle un período postoperatorio cómodo y rápido, y por sobre todo, alcanzar resultados finales satisfactorios desde el punto de vista funcional. Así vemos que en transcurso evolutivo de la cirugía prostática han aparecido diversidad de técnicas y preceptos para lograr esta finalidad, no de otra manera hubiéramos conocido las ventajas de los métodos transuretrales, la vía perineal, la clásica suprapúbica en uno o en dos tiempos y posteriormente la técnica de la prostatectomía retropúbica de Terence Millin con las modificaciones aconsejadas por Oswald Lowsley.

Horizontal biodigestor behavior at poultry litter treatment; Comportamento de um biodigestor horizontal no tratamento de cama de frango de corte

Energy Technology Data Exchange (ETDEWEB)

Alcantara, Michael Steinhorst; Citolin, Antonio Carlos; Rizelio, Wladimir; Tavares, Maria Herminia Ferreira; Gomes, Simone Damasceno [Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, PR (Brazil)], Emails: mhstavar@certto.com.br, simoned@unioeste.br

2009-07-01

This paper evaluated the biogas production and organic matter removal at poultry litter treatment in anaerobic horizontal reactor. The poultry litter was diluted with deionized water at a ratio of 5.6% of volatile solids (SV). It was used an organic load of 1.87 g SV L{sub biodigestor} {sup -1} day{sup -1} with hydraulic retention time of 30 days and 30 days for repetition. The evaluations were made daily, with TS, VS and biogas production analyses. The bioreactor stability was verified weekly, using the relation volatile acidity (VA)/total alkalinity (TA). It was utilized the Minitab 15 software, doing the statistical descriptive analysis of the data relative to biogas production, % of TS and VS removed. It was evidenced the variable 'biogas liters' has shown the largest variation coefficient, with a 1.28 L production at the 25 deg day. The average value for biogas production was 0.56 L day{sup -1} and the average values for TS and VS were 52,39 e 63,66 %, respectively. According to the Anderson Darling test, all the variables presented normality at the 5% significance. The process has shown stability through the VA/TA relation and it was concluded that it may be used at the poultry litter treatment. (author)

IceCube events and decaying dark matter: hints and constraints

Science.gov (United States)

Esmaili, Arman; Kang, Sin Kyu; Dario Serpico, Pasquale

2014-12-01

In the light of the new IceCube data on the (yet unidentified) astrophysical neutrino flux in the PeV and sub-PeV range, we present an update on the status of decaying dark matter interpretation of the events. In particular, we develop further the angular distribution analysis and discuss the perspectives for diagnostics. By performing various statistical tests (maximum likelihood, Kolmogorov-Smirnov and Anderson-Darling tests) we conclude that currently the data show a mild preference (below the two sigma level) for the angular distribution expected from dark matter decay vs. the isotropic distribution foreseen for a conventional astrophysical flux of extragalactic origin. Also, we briefly develop some general considerations on heavy dark matter model building and on the compatibility of the expected energy spectrum of decay products with the IceCube data, as well as with existing bounds from gamma-rays. Alternatively, assuming that the IceCube data originate from conventional astrophysical sources, we derive bounds on both decaying and annihilating dark matter for various final states. The lower limits on heavy dark matter lifetime improve by up to an order of magnitude with respect to existing constraints, definitively making these events—even if astrophysical in origin—an important tool for astroparticle physics studies.

IceCube events and decaying dark matter: hints and constraints

International Nuclear Information System (INIS)

Esmaili, Arman; Kang, Sin Kyu; Serpico, Pasquale Dario

2014-01-01

In the light of the new IceCube data on the (yet unidentified) astrophysical neutrino flux in the PeV and sub-PeV range, we present an update on the status of decaying dark matter interpretation of the events. In particular, we develop further the angular distribution analysis and discuss the perspectives for diagnostics. By performing various statistical tests (maximum likelihood, Kolmogorov-Smirnov and Anderson-Darling tests) we conclude that currently the data show a mild preference (below the two sigma level) for the angular distribution expected from dark matter decay vs. the isotropic distribution foreseen for a conventional astrophysical flux of extragalactic origin. Also, we briefly develop some general considerations on heavy dark matter model building and on the compatibility of the expected energy spectrum of decay products with the IceCube data, as well as with existing bounds from gamma-rays. Alternatively, assuming that the IceCube data originate from conventional astrophysical sources, we derive bounds on both decaying and annihilating dark matter for various final states. The lower limits on heavy dark matter lifetime improve by up to an order of magnitude with respect to existing constraints, definitively making these events—even if astrophysical in origin—an important tool for astroparticle physics studies

positivismo por su reduccionismo epistemológico

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Ignacio M. Ibarzábal

2007-01-01

Full Text Available A lo largo de la historia humana puede observarse la constante oscilación entre diversas teorías científicas. Esto puede demostrarse, por ejemplo, a partir de una reflexión sobre la evolución de las ideas filosóficas desde fines de la edad Media hasta la actualidad. este fenómeno no hace más que poner de relieve cierta inseguridad connatural al hombre, que genera la opción por soluciones simplistas, y “puras”, lo que culmina en muchos casos en una aproximación reduccionista a la realidad. El problema científico que plantea el reduccionismo epistemológico es que éste, al desentenderse de la realidad existencial del hombre, es incapaz de darle respuestas satisfactorias para resolver conflictos. Este inconveniente lo sufre el positivismo jurídico –así como también lo ha padecido el iusnaturalismo ingenuo–, por su imposibilidad de resolver conflictos jurídicos reales; y esto, a causa de su pretendida aproximación avalorativa que da lugar a dos especies de reduccionismos: el que desconoce tajantemente las valoraciones, y aquél que, reconociéndolas, escoge de manera arbitraria los valores objeto de su conocimiento.

Crater Topography on Titan: Implications for Landscape Evolution

Science.gov (United States)

Neish, Catherine D.; Kirk, R.L.; Lorenz, R. D.; Bray, V. J.; Schenk, P.; Stiles, B. W.; Turtle, E.; Mitchell, K.; Hayes, A.

2013-01-01

We present a comprehensive review of available crater topography measurements for Saturn's moon Titan. In general, the depths of Titan's craters are within the range of depths observed for similarly sized fresh craters on Ganymede, but several hundreds of meters shallower than Ganymede's average depth vs. diameter trend. Depth-to-diameter ratios are between 0.0012 +/- 0.0003 (for the largest crater studied, Menrva, D approximately 425 km) and 0.017 +/- 0.004 (for the smallest crater studied, Ksa, D approximately 39 km). When we evaluate the Anderson-Darling goodness-of-fit parameter, we find that there is less than a 10% probability that Titan's craters have a current depth distribution that is consistent with the depth distribution of fresh craters on Ganymede. There is, however, a much higher probability that the relative depths are uniformly distributed between 0 (fresh) and 1 (completely infilled). This distribution is consistent with an infilling process that is relatively constant with time, such as aeolian deposition. Assuming that Ganymede represents a close 'airless' analogue to Titan, the difference in depths represents the first quantitative measure of the amount of modification that has shaped Titan's surface, the only body in the outer Solar System with extensive surface-atmosphere exchange.

El centro histórico de Barranquilla: problemáticas ambientales y sociales

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Myriam Graciela Bonilla Becerra

2007-01-01

Full Text Available Los procesos de rehabilitación de los centros históricos en diversas ciudades del mundo, no solo se enfocan en los aspectos arquitectónicos o de espacio público, sino que deben atender los problemas ambientales. El centro histórico es por lo general el área con mayor degradación ambiental a nivel de contaminación atmosférica, contaminación por ruido, manejo de residuos sólidos y otras formas de contaminación de la ciudad; pero en el caso de Barranquilla el sistema de caños de la ciudad ha sido afectado por las actividades propias de su centro histórico, llevándolos a un estado de degradación y contaminación que no ha sido solucionado en forma definitiva. La recuperación de los caños de Barranquilla es un asunto prioritario y es por esto que el gobierno colombiano ha aprobado la “Implementación Plan de Saneamiento de los Caños de la Cuenca Oriental de la Ciudad de Barranquilla”, cuyo costo asciende 75.554 millones de pesos. Lo que permitirá darle una nueva cara al centro histórico de la ciudad.

El conflicto universitario (1999-2000 a la luz del discurso escrito

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Georgina Paulín Pérez

2000-01-01

Full Text Available El presente artículo recoge los resultados preliminares de una ambiciosa investigación semántica que examina detenidamente el manejo del conflicto universitario por parte de los principales medios escritos del país. El encuadramiento que estos medios han dado al conflicto parece concentrarse en dos líneas interpretativas que, tal y como lo demuestra esta investigación, no logran agotar adecuadamente sus complejidad interna. La primera de estas líneas de anilisis sostiene que el conflicto es la "única" altemativa que se ha dejado a la comunidad universitaria frente a los proyectos de transformación de la universidad dictados desde las altas esferas de las estructuras de poder. La segunda línea, en cambio, estima que la reacción de protesta de los estudiantes constituye el producto de una indeseable, innecesaria e inadecuada "salida" a los impulsos agresivos y las energías mal encauzadas del estudiantado de la universidad. Ambas interpretaciones son parciales y sesgadas. En este sentido, el artículo sostiene, como parte de sus conclusiones provisionales, que los medios periodísticos no han logrado superar las tentaciones de darle al conflicto un manejo sensacionalista y distorsionador del fenómeno en cuestión.

Miguel E. Bustamante. Un pilar de la Salud pública moderna en México

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Héctor Gómez Dantés

2017-01-01

Full Text Available Sociedad Mexicana de Salud Pública y la Fundación Carlos Slim tuvieron a bien regalarnos un texto que hace la semblanza –honorable y justa– de un mexicano excepcional. El texto ofrece la biografía del Dr. Miguel Enrique Bustamante Vasconcelos, oaxaqueño de origen pero mexicano universal por destino. Sin responder a un homenaje por su natalicio (2 de mayo de 1898 o por el aniversario de su muerte (4 de enero de 1986 –acaso 30 años más tarde–aparece este libro, elegante en su edición gracias al cuidado y la minuciosa investigación histórica, documental  e iconográfica de Ediciones Clío. Más allá de las atinadas motivaciones que tuvieron los coordinadores de esta obra –los doctores Rafael Lozano y Roberto Tapia Conyer– para embarcarse en su elaboración, es preciso darles un aplauso pues nunca es tarde para apreciar la labor de otros; dar una verdadera dimensión a su legado; recuperar su dignidad; identificar sus enseñanzas y mantener viva su memoria.

Ser cuidada por profissionais da saúde: percepções e sentimentos de mulheres que sofreram abortamento

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Kellen Daiane Valandro Bazotti

2009-01-01

Full Text Available El objetivo de la investigación es identificar las percepciones y sentimientos de mujeres que sufrieron aborto, principalmente, las relacionadas al cuidado de profesionales de la salud en un hospital. Es un estudio cualitativo, exploratorio-descriptivo. Los instrumentos para la recolección de los datos fueron: entrevista abierta y registro en el diario de campo. La recolección de los datos se hizo en dos momentos: durante la internación hospitalaria y en los domicilios. Integraron la investigación cinco mujeres que tuvieron aborto espontáneo. Para el análisis de las declaraciones se utilizó el análisis temático, del cual emergió una categoría: "ser cuidada" en un hospital: la visión de mujeres que abortaron, dividida en nueve subcategorías. Varios sentimientos y percepciones fueron mencionados, incluyendo miedo, nerviosismo, tristeza, vergüenza, dolor por la pérdida del hijo, satisfacción con la atención de los profesionales, apoyo, seguridad, entre otros. Esa investigación puede ser una contribución para los profesionales y estudiantes del área de la salud, en el sentido de permitirles reflexionar y darle calidad a la atención.

Three new species of Diascia (Scrophulariaceae from the Western Cape, South Africa

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K. E. Steiner

2009-08-01

Full Text Available Three new annual species of Diascia Link & Otto are described from the Western Cape Province of South Africa. D. collina is characterized by greyish magenta flowers with two divergent yellow sacs containing oil-secreting trichomes. It is restricted to granite outcrops in the vicinity of Saldanha Bay, from the West Coast National Park and Langebaan north to Vredenburg. D. pusilla is closely related to D. collina. but differs from that species in having smaller flowers with shorter, ± parallel sacs, and posticous filaments that lack a protuberance where they bend sharply backwards towards the upper lip. It occurs in grey to whitish sands usually near seasonally moist or wet areas. It has not been found more than 35 km from the coast and ranges from Modderrivier, south o f Darling, north to Lambert’s Bay. D. appendiculata is related to D. diffusa (Thunb. Benth. and is characterized by having small, mainly reddish lilac to greyish magenta flowers, two shallow depressions in the corolla tube at the base of the upper lip, and posticous filaments with sterile appendages. It is known from only six localities in the general vicinity of Citrusdal and occurs in fynbos vegetation on lower mountain slopes or flats, in loose alluvial sands derived from Table Mountain Sandstone.

El crédito a principios del siglo XVI en una ciudad de Castilla: la nobleza urbana como financiadora del comercio y de la industria en Segovia, 1503-1508

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Ángel GARCÍA-SANZ MARCOTEGUI

2009-12-01

Full Text Available Al principiar el mes de julio de 1969 defendía yo mi Memoria de Licenciatura en Historia en una de las viejas aulas del Palacio Anaya de Salamanca. D. Manuel Fernández Álvarez era el director del trabajo, que se titulaba Campesinos y mercaderes en Segovia durante la crisis agraria de 1502 a 1508. Recuerdo perfectamente que el tribunal estaba formado por el entrañable D. Rafael Laínez Alcalá, como Presidente; D. Manuel, el director, D. Ángel Cabo Alonso y D. Francisco Jordá Cerda eran los Vocales; Secretario era D. José Luis Martín Rodríguez, que había llegado a Salamanca como Catedrático de Medieval dos años antes. Recuerdo también que fueron muy amables conmigo, y generosos en la calificación, por lo que ahora, veinte años después, quiero darles las gracias en letra de imprenta, sintiendo que a D. Rafael no pueda ser ya más que a título postumo. Mi agradecimiento a ellos se extiende a cuantos fueron profesores míos en Salamanca, de cuya Universidad tengo muy a gala ser Licenciado.

Symmetric subgroup orbit closures on flag varieties: Their equivariant geometry, combinatorics, and connections with degeneracy loci

Science.gov (United States)

Wyser, Benjamin J.

The purpose of this study was to compare both traditional and Temporary Authorization Certificate (TAC) teacher's implementation of the state standards of education. The quality of teacher performance is a vital issue for school districts. Teacher quality is essential to increase student achievement. Since 2001, the state under study has experienced teacher shortages, and used a 1 year renewable certificate that does not require previous completion of a teacher education program. The theoretical base for the study included Darling-Hammond, Holtzman, and Heilig's research related to teacher quality dependent on teacher preparation and certification. The research questions were used to compare TAC with traditionally prepared teacher performance on 6 dimensions. Data for the comparative analysis were collected using a survey of high school principals who completed performance evaluations of both traditional and TAC certified teachers. Using descriptive statistics and independent-samples t tests, it was observed that while traditional teachers received greater mean scores on every dimension, the differences were statistically significant for the scales of organization of instruction, classroom management, and addressing diversity. The results may contribute to positive social change by presenting potential areas of growth for TAC teachers, which may positively impact the educational experience of students in high-need districts hiring alternatively certified teachers.

Conjunto de técnicas de motivación para elevar la práctica del ejercicio físico en edades de 30 a 50 años del sexo femenino en el Reparto Ceferino Fernández

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Marlen de la Caridad Labrador Vento

2009-09-01

Full Text Available La poca motivación del sexo femenino por la práctica del ejercicio físico, y más significativo en la edades de 30 a 50 años, es algo muy generalizado en las comunidades del municipio de Pinar del Río. Para darle solución a esta situación, se realizó un estudio de los motivos por los cuales las féminas no practican el ejercicio físico, en el consultorio # 38 del Reparto Ceferino Fernández, y se obtuvo como resultado fundamentalmente la falta de comunicación e información de la importancia que reviste para elevar la calidad de vida, la práctica sistemática del ejercicio físico, por parte de los diferentes factores de la comunidad, del profesor de cultura física y del médico del consultorio. Todo ello estuvo sustentado a través del uso de diferentes métodos investigativos, los que permitieron potenciar los criterios expresados por diferentes autores acerca de la motivación por las actividades y la importancia de la práctica del ejercicio físico.

Horizontal biodigestor behavior at poultry litter treatment; Comportamento de um biodigestor horizontal no tratamento de cama de frango de corte

Energy Technology Data Exchange (ETDEWEB)

Alcantara, Michael Steinhorst; Citolin, Antonio Carlos; Rizelio, Wladimir; Tavares, Maria Herminia Ferreira; Gomes, Simone Damasceno [Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, PR (Brazil)], Emails: mhstavar@certto.com.br, simoned@unioeste.br

2009-07-01

This paper evaluated the biogas production and organic matter removal at poultry litter treatment in anaerobic horizontal reactor. The poultry litter was diluted with deionized water at a ratio of 5.6% of volatile solids (SV). It was used an organic load of 1.87 g SV L{sub biodigestor} {sup -1} day{sup -1} with hydraulic retention time of 30 days and 30 days for repetition. The evaluations were made daily, with TS, VS and biogas production analyses. The bioreactor stability was verified weekly, using the relation volatile acidity (VA)/total alkalinity (TA). It was utilized the Minitab 15 software, doing the statistical descriptive analysis of the data relative to biogas production, % of TS and VS removed. It was evidenced the variable 'biogas liters' has shown the largest variation coefficient, with a 1.28 L production at the 25 deg day. The average value for biogas production was 0.56 L day{sup -1} and the average values for TS and VS were 52,39 e 63,66 %, respectively. According to the Anderson Darling test, all the variables presented normality at the 5% significance. The process has shown stability through the VA/TA relation and it was concluded that it may be used at the poultry litter treatment. (author)

Uncertainty of Hydrological Drought Characteristics with Copula Functions and Probability Distributions: A Case Study of Weihe River, China

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Panpan Zhao

2017-05-01

Full Text Available This study investigates the sensitivity and uncertainty of hydrological droughts frequencies and severity in the Weihe Basin, China during 1960–2012, by using six commonly used univariate probability distributions and three Archimedean copulas to fit the marginal and joint distributions of drought characteristics. The Anderson-Darling method is used for testing the goodness-of-fit of the univariate model, and the Akaike information criterion (AIC is applied to select the best distribution and copula functions. The results demonstrate that there is a very strong correlation between drought duration and drought severity in three stations. The drought return period varies depending on the selected marginal distributions and copula functions and, with an increase of the return period, the differences become larger. In addition, the estimated return periods (both co-occurrence and joint from the best-fitted copulas are the closet to those from empirical distribution. Therefore, it is critical to select the appropriate marginal distribution and copula function to model the hydrological drought frequency and severity. The results of this study can not only help drought investigation to select a suitable probability distribution and copulas function, but are also useful for regional water resource management. However, a few limitations remain in this study, such as the assumption of stationary of runoff series.

Reduced dimension rovibrational variational calculations of the S{sub 1} state of C{sub 2}H{sub 2}. II. The S{sub 1} rovibrational manifold and the effects of isomerization

Energy Technology Data Exchange (ETDEWEB)

Changala, P. Bryan, E-mail: bryan.changala@colorado.edu; Baraban, Joshua H.; Field, Robert W. [Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Stanton, John F. [Department of Chemistry and Biochemistry, Institute for Theoretical Chemistry, The University of Texas at Austin, Austin, Texas 78712 (United States); Merer, Anthony J. [Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan and Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1 (Canada)

2014-01-14

Reduced dimension variational calculations have been performed for the rovibrational level structure of the S{sub 1} state of acetylene. The state exhibits an unusually complicated level structure, for various reasons. First, the potential energy surface has two accessible conformers, trans and cis. The cis conformer lies about 2700 cm{sup −1} above the trans, and the barrier to cis-trans isomerization lies about 5000 cm{sup −1} above the trans minimum. The trans vibrations ν{sub 4} (torsion) and ν{sub 6} (asym. bend) interact very strongly by Darling-Dennison and Coriolis resonances, such that their combination levels and overtones form polyads with unexpected structures. Both conformers exhibit very large x{sub 36} cross-anharmonicity since the pathway to isomerization is a combination of ν{sub 6} and ν{sub 3} (sym. bend). Near the isomerization barrier, the vibrational levels show an even-odd K-staggering of their rotational levels as a result of quantum mechanical tunneling through the barrier. The present calculations address all of these complications, and reproduce the observed K-structures of the bending and C–C stretching levels with good qualitative accuracy. It is expected that they will assist with the assignment of the irregular patterns near the isomerization barrier.

Utilización del polvo de acería de horno de arco eléctrico. // Use of powder produced by electric arc furnaces at steel plants.

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D. Tápanes Robau

2001-01-01

Full Text Available El polvo de las Acerías de Horno de Arco Eléctrico se produce como consecuencia de la producción de Acero, durante ladepuración de los gases, y, en menor medida, en sus equipos de captación de aire. Estos polvos deben ser captados por lossistemas de depuración del taller. Con el presente trabajo pretendemos darle utilidad a un producto de desecho como es elpolvo, mejorar las condiciones ambientales en el taller, elevar la calidad del pavimento u hormigón asfáltico mediante lavariación de sus propiedades y disminuir el costo de la tonelada de acero mediante la comercialización de estos productosde desecho.Palabras claves: Polvos, aglutinantes, composición química, pruebas realizadas._______________________________________________________________________________SummaryThe powder generated by electric arc furnaces at steel plants is the result of processes such as the production of steel, thepurification of gases and, capturing air equipment .This article shows a method for recycling waste material – powder in this case- which also contributes to improve the steelplant environment, provides the possibility of improving asphalt paving and makes the production of steel cheaper throughthe commercialization of waste materials.Key words: Powder, binder, tests, chemical composition.

CARACTERIZACIÓN FISICOQUÍMICA Y ACTIVIDAD ANTIOXIDANTE DE EXTRACTOS DE JAMAICA (Hibiscus sabdariffa L. NACIONAL E IMPORTADA

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L. A. Galicia-Flores

2008-01-01

Full Text Available En el presente estudio se analizaron muestras de jamaica importada (Sudán y China y de México (Guerrero para determinar el color de sus cálices las bebidas preparadas con sus extractos, además del pH, acidez, perfil de antocianinas y la actividad antioxidante, a fin de encontrar si existen diferencias que pudieran repercutir en su apreciación comercial. Las soluciones preparadas con los extractos de jamaica China y México presentaron una coloración rojo brillante, mientras la muestra de Sudán fue café-rojizo. La muestra de México mostró los porcentajes de acidez más altos y los valores más bajos de pH, en tanto que la jamaica China tuvo la mayor concentración de antocianinas. Los extractos de las tres jamaicas presentaron el mismo perfil de antocianinas, obtenido mediante HPLC. De acuerdo con los parámetros de calidad determinados, la jamaica de México y China tiene mejor calidad que la de Sudán. El extracto de jamaica de México fue el que presentó la mayor actividad antioxidante, lo que podría ayudar a darle un valor agregado a la jamaica (Hibiscus sabdaritfa L. mexicana.

Procesos básicos en una aproximación cognitivo-conductual a los trastornos de personalidad

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Miguel Ángel Pérez Nieto

2007-01-01

Full Text Available El presente trabajo pretende revisar el protagonismo de procesos psicológicos básicos en la actual conceptualización de los trastornos de personalidad (TTPP, sus modelos explicativos más relevantes y las terapias cognitivo-conductuales centradas en estos trastornos. Para ello se revisará la tendencia actual a una aproximación más dimensional que categorial a los TTPP señalando la mayor relevancia implícita que en esa perspectiva tendrán los procesos psicológicos básicos. Para revisar el protagonismo de estos procesos se presentarán distintos modelos teóricos: el modelo de los siete factores, la aproximación desde el modelo de los cinco grandes, el modelo biosocial, y aproximación desde los modelos cognitivos. También se presentarán los principios de las dos terapias cognitivo-conductuales propias de los TTPP. Una vez presentado el estado actual de la cuestión se revisa el papel de la percepción, la atención, la memoria, el aprendizaje, la emoción y la impulsividad y su afrontamiento y regulación en la los modelos y terapias cognito-conductuales presentados, discutiendo sobre la necesidad de darles mayor protagonismo.

Home health care logistics management problems: a critical review of models and methods

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Elena Valentina Gutiérrez

2013-01-01

Full Text Available Los servicios de Hospitalización Domiciliaria (HD se basan en una red de distribución, en la cual los pacientes son hospitalizados en sus casas y los prestadores de servicios de salud deben entregar cuidados médicos coordinados a los pacientes. La demanda de estos servicios está creciendo rápidamente y los gobiernos y proveedores de servicios de salud enfrentan el reto de tomar un conjunto de decisiones complejas en un sector con un componente logístico importante. En este artículo se presenta una revisión crítica de los modelos y métodos utilizados para darle soporte a las decisiones logísticas en HD. Para esto se presenta primero un marco de referencia, con el objetivo de identificar las oportunidades de investigación en el campo. Con base en dicho marco, se presenta la revisión de la literatura y la identificación de brechas en la investigación. En particular, se hace énfasis en la necesidad de desarrollar e implementar metodologías más integradas para dar soporte a las decisiones estratégicas y tácticas y de considerar puntos clave de los sistemas reales.

Enacting resilience for adaptive water governance: a case study of irrigation modernization in an Australian catchment

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Margaret L. Ayre

2017-09-01

Full Text Available Adaptive governance relies on the collaboration of a diverse set of stakeholders in multiple institutions and organizations at different times and places. In the context of unprecedented water policy and management reform in Australia over the past decade, we add to insights from resilience scholarship, which identifies adaptive governance as critical to improving complex social-ecological systems, such as water management. We present empirical research with agricultural industry stakeholders who are responding to a major change initiative to renew or modernize the largest irrigation system in Australia's Murray Darling Basin and who ask: "What can a resilience assessment intervention contribute to adaptive water governance in this context?" Using resilience approaches and connecting these with insights from science and technology studies (STS, we found that a particular resilience assessment intervention supported dairy industry stakeholders to manage the complexity, uncertainty, and diversity of an irrigation modernization governance challenge. It did so by explicitly accounting for, representing, and aligning different water governing practices through the use of resilience concepts, a particular resilience assessment tool, and a participatory process for engaging social actors. Possibilities for adaptive governance emerged from the intervention in the form of new joint strategic actions and new understandings, alliances, and roles between people and institutions for addressing irrigation modernization.

Aprender a enseñar en el siglo XIX. La formación inicial de las maestras españolas

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Teresa GONZÁLEZ PÉREZ

2010-01-01

Full Text Available La irrupción de las mujeres en la Escuela, como alumnas y como enseñantes, comenzó muy tímidamente en la España del siglo XVIII, si bien no fue hasta finales del siglo XIX, con la Ley Moyano (1857, cuando se estableció la obligatoriedad de la instrucción primaria pública para las niñas. Pero las políticas educativas no sólo posibilitaron progresivamente la incorporación y la permanencia de las niñas en la institución escolar. También se hizo efectivo el ingreso de las mujeres en la profesión docente, ingreso que en un principio quedaba reducido a la enseñanza primaria y que respondía más a una cuestión de utilidad que a un interés social por darles a las mujeres la oportunidad de mejorar su formación para su incorporación al mercado laboral. En este trabajo nos proponemos analizar la trayectoria de la formación inicial de las maestras españolas, diseñada según el programa curricular concretado en diferentes planes de estudio a lo largo del siglo XIX.

Transplantes de Medula Óssea no Brasil: Dimensão Bioética

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Marcelo Moreira Corgozinho

2012-01-01

Full Text Available El presente estudio busca analizar la práctica de los trasplantes de médula ósea en Brasil a la luz de la Bioética. Partiendo del presupuesto constitucional brasileño de que la salud es un derecho de todas las personas, analiza el acceso a estos servicios médicos especializados por parte de los ciudadanos socialmente vulnerables. Presenta el panorama legal de este campo del conocimiento científico en el país, mostrando la legislación general relativa a los trasplantes de órganos y tejidos, además de la reglamentación específica relacionada con los trasplantes de médula ósea, incluyendo la logística pública de apoyo al desarrollo del proceso de atención médica. Considerando aspectos relacionados con el uso de células tronco hematopoyéticas y tomando la bioética como referencia, discute la vulnerabilidad de los pacientes de bajas condiciones socio-económicas, la responsabilidad pública del Estado para con esas personas y la necesidad de darles la debida protección, teniendo en cuenta los patrones sociales de desigualdad observados en los países periféricos como Brasil.

Building the perfect parasite: cell division in apicomplexa.

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Boris Striepen

2007-06-01

Full Text Available Apicomplexans are pathogens responsible for malaria, toxoplasmosis, and crytposporidiosis in humans, and a wide range of livestock diseases. These unicellular eukaryotes are stealthy invaders, sheltering from the immune response in the cells of their hosts, while at the same time tapping into these cells as source of nutrients. The complexity and beauty of the structures formed during their intracellular development have made apicomplexans the darling of electron microscopists. Dramatic technological progress over the last decade has transformed apicomplexans into respectable genetic model organisms. Extensive genomic resources are now available for many apicomplexan species. At the same time, parasite transfection has enabled researchers to test the function of specific genes through reverse and forward genetic approaches with increasing sophistication. Transfection also introduced the use of fluorescent reporters, opening the field to dynamic real time microscopic observation. Parasite cell biologists have used these tools to take a fresh look at a classic problem: how do apicomplexans build the perfect invasion machine, the zoite, and how is this process fine-tuned to fit the specific niche of each pathogen in this ancient and very diverse group? This work has unearthed a treasure trove of novel structures and mechanisms that are the focus of this review.

Alterações anatomopatológicas renais em indivíduos com a síndrome da imunodeficiência adquirida

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Laguna-Torres Victor Alberto

1998-01-01

Full Text Available As alterações anatomopatológicas renais foram estudadas em 119 casos de indivíduos com a síndrome da imunodeficiência humana adquirida (SIDA no Hospital Escola da Faculdade de Medicina do Triângulo Mineiro, Uberaba MG. A partir das amostras de rim fixadas em formol, foram confeccionadas lâminas e analisadas ao microscópio de luz. Dos 119 casos estudados, 67 tiveram diagnóstico de nefrite túbulo intersticial (NTI, sendo 18 inespecíficas, 2 xantogranulomatosas e encontrou-se agente infeccioso em 48: fungos em 28 (16 Cryptococcus sp, 9 Histoplasma sp, 1 Candida sp e 2 Paracoccidioides brasiliensis; bactérias em 18 (9 Mycobacterium sp; vírus em 6, Citomegalovírus. Em 43 havia necrose tubular aguda (NTA. Outros diagnósticos foram: nefrocalcinose (15,1% e hialinose arteriolar (22,7%. Encontrou-se também 2 casos com glomeruloesclerose segmentar focal (GESF e um caso de hiperplasia mesangial difusa. Houve predomínio da NTI, que pode ser devido às infecções oportunistas, predominando as fúngicas; a toxicidade por drogas ou ainda devido a possível ação direta do próprio vírus. A necrose tubular aguda (NTA, foi a segunda causa em freqüência, de acometimento renal da amostra. Concluiu-se que o envolvimento renal nos pacientes com SIDA apresenta um espectro variado de processos patológicos, principalmente relacionados com infecções oportunistas, o tratamento e os procedimentos para diagnósticos, e ainda as nefropatias associadas ao vírus da imunodeficiência humana (VIH.

Unexpected mechanical properties of very dry Berea sandstone near 45°C

Science.gov (United States)

Miller, R. A.; Darling, T. W.; TenCate, J. A.; Johnson, P. A.

2011-12-01

Office of Basic Energy Sciences]. [1] B. R. Tittmann, L. Ahlberg, and J. Curnow, "Internal friction and velocity measurements," Proc. of 7th Lunar Science Conference , pp. 3123-3132, 1997. [2] K. E.-A. Van Den Abeele, J. Carmeliet, P. A. Johnson, and B. Zinszner, "Influence of water saturation on the nonlinear elastic mesoscopic response in Earth materials and the implications to the mechanism of nonlinearity," Journal of Geophysical Research 107, p. 2121, June 2002. [3] "Dynamic Measures of Elastic Nonlinear (Anelastic) Behavior: Dynamic Acousto-Elasticity Testing (DAET)," G. Renaud, P-Y Le Bas, J. A. TenCate, T. J. Ulrich, J. W. Carey, J. Han, T.W. Darling and P. A. Johnson, AGU Fall Meeting, Dec. 2011. [4] "Water and CO2 chemistry influences on the mechanical integrity of rocks," T.W. Darling, P-Y Le Bas, J. W. Carey, P. A. Johnson and R. A. Miller, AGU Fall Meeting, Dec. 2010.

Acometimento pulmonar em crianças com a síndrome da imunodeficiência humana (AIDS: estudo clínico e de necrópsia de 14 casos Necroscopic study of 14 children with AIDS and pneumonia

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I.T.R. YPARRAGUIRRE

2001-06-01

Full Text Available OBJETIVOS: Descrever os aspectos clínicos, laboratoriais, radiológicos e anatomopatológicos encontrados em tecidos pulmonares de necrópsias de crianças com Aids e acometimento pulmonar. MÉTODOS: Foram revisados, retrospectivamente, prontuários, radiografias simples de tórax e laudos de necrópsias de 14 crianças com Aids e acometimento pulmonar. RESULTADOS: Oito casos eram do sexo masculino e seis do feminino. As idades variaram de três meses a nove anos, mediana de 1,2, sendo nove deles menores de dois anos. A transmissão foi vertical em 10 pacientes, dos quais cinco mães tinham história de contaminação por relação heterossexual; três, por hemotransfusão e em duas, ignorada. Pneumonia (n=8, candidíase oral (n=8 e diarréia (n=5 foram as doenças prévias mais referidas. Os sinais e sintomas observados à internação foram febre (n=12, dispnéia (n=10, tosse (n=11, linfoadenomegalia (n=11, hepato e/ou esplenomegalia (n=10, desnutrição (n=9, palidez (n=8, cianose (n=5 e baqueteamento digital (n=2. Os achados radiológicos mais comuns foram infiltrados difusos (n=6 e condensações (n=5. As alterações histológicas pulmonares foram compatíveis com pneumonia pelo citomegalovírus (n=9, por bactérias (n=8, por Pneumocystis carinii (n=3, por Hystoplasma capsulatum (n=1, por Toxoplasma gondii (n=1 e pneumonia intersticial linfocítica (n=1. A associação CMV e bactéria foi observada em seis casos. CONCLUSÕES: Houve predomínio de menores de dois anos, de transmissão vertical, de quadro clínico inespecífico de doença pulmonar e de infiltrados e condensações à radiografia. Citomegalovírus e bactérias foram os agentes mais comuns, sendo freqüente a sua associação. Pneumonia Intersticial Linfocítica e Pneumonia pelo P. carinii não foram causas freqüentes de doenças pulmonares.BACKGROUND: To describe clinical, laboratorial, radiological, and histopathological lung findings from necroscopy of aidetic children