High Gradient Accelerator Research

International Nuclear Information System (INIS)

Temkin, Richard

2016-01-01

The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave cold test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.

A randomised controlled study of standard versus accelerated deflation of the Terumo radial band haemostasis device after transradial diagnostic cardiac catheterisation.

Science.gov (United States)

Deuling, J Han; Vermeulen, Robert P; van den Heuvel, Ad Fm; Schurer, Remco Aj; van der Harst, Pim

2017-04-01

Radial access is the preferential access route in patients undergoing diagnostic coronary angiography. We hypothesised that we could reduce hospital stay and improve patient comfort by accelerated deflation of the radial compression device (Terumo radial band). The aim of this study was to compare accelerated pressure reduction with a standard Terumo radial band protocol with regard to local bleeding complications and reported pain scores after cardiac catheterisation. We performed a single centre prospective randomised trial to compare accelerated care to standard care for patients undergoing diagnostic catheterisation through radial access. Patients in the accelerated care group started deflation after 1 hour, with a 2 ml/10-minute interval. Patients in the standard care group started after 2 hours with additional steps of deflation at 3 and 4 hours. Of the 173 analysed patients 86 received accelerated care and 87 patients standard care. A total of 19 patients had pulsatile bleeding, which occurred similarly in the two groups (standard care 11 vs. accelerated care 8, P=0.47). The time to Terumo radial band removal was on average 129 minutes shorter for accelerated care patients compared to standard care ( P<0.01). At 1 hour after Terumo radial band placement, accelerated care patients more often reported pain scores of 0 than standard care patients (89% vs. 74%, P=0.02). There was no increase in local bleedings in the accelerated pressure reduction of the Terumo radial band after diagnostic cardiac catheterisation, increasing patient comfort and reducing hospital stay. These findings will further facilitate the widespread implementation of radial access.

PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes

International Nuclear Information System (INIS)

Chen, Min; Wang, Yanru; Qu, Aijuan

2010-01-01

Energy metabolism and Ca 2+ handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1α in cardiac Ca 2+ signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1α via adenoviral transduction. Our data shows that overexpressing PGC-1α improved myocyte contractility without increasing the amplitude of Ca 2+ transients, suggesting that myofilament sensitivity to Ca 2+ increased. Interestingly, the decay kinetics of global Ca 2+ transients and Ca 2+ waves accelerated in PGC-1α-expressing cells, but the decay rate of caffeine-elicited Ca 2+ transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2a), but not Na + /Ca 2+ exchange (NCX) contribute to PGC-1α-induced cytosolic Ca 2+ clearance. Furthermore, PGC-1α induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1α did not disturb cardiac Ca 2+ homeostasis, because SR Ca 2+ load and the propensity for Ca 2+ waves remained unchanged. These data suggest that PGC-1α can ameliorate cardiac Ca 2+ cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1α-calcium handing pathway sheds new light on the role of PGC-1α in the therapy of cardiac diseases.

Accelerated high-frame-rate mouse heart cine-MRI using compressed sensing reconstruction.

Science.gov (United States)

Motaal, Abdallah G; Coolen, Bram F; Abdurrachim, Desiree; Castro, Rui M; Prompers, Jeanine J; Florack, Luc M J; Nicolay, Klaas; Strijkers, Gustav J

2013-04-01

We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exploit the stochastic nature of the retrospective triggering acquisition scheme to produce an undersampled and random k-t space filling that allows for compressed sensing reconstruction and acceleration. As a standard, a self-gated FLASH sequence with a total acquisition time of 10 min was used to produce single-slice Cine movies of seven mouse hearts with 90 frames per cardiac cycle. Two times (2×) and three times (3×) k-t space undersampled Cine movies were produced from 2.5- and 1.5-min data acquisitions, respectively. The accelerated 90-frame Cine movies of mouse hearts were successfully reconstructed with a compressed sensing algorithm. The movies had high image quality and the undersampling artifacts were effectively removed. Left ventricular functional parameters, i.e. end-systolic and end-diastolic lumen surface areas and early-to-late filling rate ratio as a parameter to evaluate diastolic function, derived from the standard and accelerated Cine movies, were nearly identical. Copyright © 2012 John Wiley & Sons, Ltd.

A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.

Directory of Open Access Journals (Sweden)

Paul W Burridge

2011-04-01

Full Text Available The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC holds great promise for patient-specific cardiotoxicity drug testing, disease modeling, and cardiac regeneration. However, existing protocols for the differentiation of hiPSC to the cardiac lineage are inefficient and highly variable. We describe a highly efficient system for differentiation of human embryonic stem cells (hESC and hiPSC to the cardiac lineage. This system eliminated the variability in cardiac differentiation capacity of a variety of human pluripotent stem cells (hPSC, including hiPSC generated from CD34(+ cord blood using non-viral, non-integrating methods.We systematically and rigorously optimized >45 experimental variables to develop a universal cardiac differentiation system that produced contracting human embryoid bodies (hEB with an improved efficiency of 94.7±2.4% in an accelerated nine days from four hESC and seven hiPSC lines tested, including hiPSC derived from neonatal CD34(+ cord blood and adult fibroblasts using non-integrating episomal plasmids. This cost-effective differentiation method employed forced aggregation hEB formation in a chemically defined medium, along with staged exposure to physiological (5% oxygen, and optimized concentrations of mesodermal morphogens BMP4 and FGF2, polyvinyl alcohol, serum, and insulin. The contracting hEB derived using these methods were composed of high percentages (64-89% of cardiac troponin I(+ cells that displayed ultrastructural properties of functional cardiomyocytes and uniform electrophysiological profiles responsive to cardioactive drugs.This efficient and cost-effective universal system for cardiac differentiation of hiPSC allows a potentially unlimited production of functional cardiomyocytes suitable for application to hPSC-based drug development, cardiac disease modeling, and the future generation of clinically-safe nonviral human cardiac cells for regenerative medicine.

High intensity circular proton accelerators

International Nuclear Information System (INIS)

Craddock, M.K.

1987-12-01

Circular machines suitable for the acceleration of high intensity proton beams include cyclotrons, FFAG accelerators, and strong-focusing synchrotrons. This paper discusses considerations affecting the design of such machines for high intensity, especially space charge effects and the role of beam brightness in multistage accelerators. Current plans for building a new generation of high intensity 'kaon factories' are reviewed. 47 refs

Cardiac troponins--Translational biomarkers in cardiology: Theory and practice of cardiac troponin high-sensitivity assays.

Science.gov (United States)

Adamcova, Michaela; Popelova-Lencova, Olga; Jirkovsky, Eduard; Simko, Fedor; Gersl, Vladimir; Sterba, Martin

2016-01-01

Tn is a unique translational biomarker in cardiology whose potential has not been diminished in the new era of high sensitive assays. cTns can be valuable markers in cardiac diseases as well as in infectious diseases and respiratory diseases. Furthermore, the role of cTns is growing in the routine evaluation of cardioxicity and in determining the efficacy/safety ratio of novel cardioprotective strategies in clinical settings. cTns can detect myocardial injury not only in a wide spectrum of laboratory animals in experimental studies in vivo, but also in isolated heart models or cardiomyocytes in vitro. The crucial issue regarding the cross-species usage of cardiac troponin investigation remains the choice of cardiac troponin testing. This review summarizes the recent proteomic data on aminoacid sequences of cTnT and cTnI in various species, as well as selected analytical characteristics of human cardiac troponin high-sensitivity assays. Due to the highly phylogenetically conserved structure of troponins, the same bioindicator can be investigated using the same method in both clinical and experimental cardiology, thus contributing to a better understanding of the pathogenesis of cardiac diseases as well as to increased effectiveness of troponin use in clinical practice. Measuring cardiac troponins using commercially available human high-sensitivity cardiac troponin tests with convenient antibodies selected on the basis of adequate proteomic knowledge can solve many issues which would otherwise be difficult to address in clinical settings for various ethical and practical reasons. Our survey could help elaborate the practical guidelines for optimizing the choice of cTns assay in cardiology. © 2016 International Union of Biochemistry and Molecular Biology.

Cardiac Acceleration at the Onset of Exercise : A Potential Parameter for Monitoring Progress During Physical Training in Sports and Rehabilitation

NARCIS (Netherlands)

Hettinga, Florentina J.; Monden, Paul G.; van Meeteren, Nico L. U.; Daanen, Hein A. M.

There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were

Cardiac acceleration at the onset of exercise: A potential parameter for monitoring progress during physical training in sports and rehabilitation

NARCIS (Netherlands)

Hettinga, F.J.; Monden, P.G.; Meeteren, N.L.U. van; Daanen, H.A.M.

2014-01-01

There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were

The effects of ionizing radiation on eight cardiac pacemakers and the influence of electromagnetic interference from two linear accelerators

International Nuclear Information System (INIS)

Venselaar, J.L.M.

1985-01-01

Eight cardiac pacemakers were irradiated in a cobalt-60 beam. Two out of six demand-type pacemakers showed an alarming decrease in pulse repetition frequency when irradiated to dose levels that are used in radiotherapy. Two modern programmable pacemakers showed a failure at a dose of 97 and 147 Gy, respectively. The dose levels at which these failures occurred were low enough to recommend that cardiac pacemakers should always be kept outside the radiation beam. The signals induced by electromagnetic interference (EMI) from two linear accelerators were measured using a simulation model of a pacemaker. In the laboratory, 22 modern-type pacemakers were tested with these signals to determine the sensitivity for the electromagnetic fields in the treatment rooms. It was observed that an inhibition of one pacemaker pulse was to be expected on one of the two linear accelerators when switching the machine on and off. No permanent effects were found. These findings resulted in the recommendation in our department not to use this treatment machine for radiation therapy of pacemaker-bearing patients. (orig.)

High intensity proton accelerator program

International Nuclear Information System (INIS)

Kaneko, Yoshihiko; Mizumoto, Motoharu; Nishida, Takahiko

1991-06-01

Industrial applications of proton accelerators to the incineration of the long-lived nuclides contained in the spent fuels have long been investigated. Department of Reactor Engineering of Japan Atomic Energy Research Institute (JAERI) has formulated the Accelerator Program through the investigations on the required performances of the accelerator and its development strategies and also the research plan using the accelerator. Outline of the Program is described in the present report. The target of the Program is the construction of the Engineering Test Accelerators (ETA) of the type of a linear accelerator with the energy 1.5 GeV and the proton current ∼10 mA. It is decided that the construction of the Basic Technology Accelerator (BTA) is necessary as an intermediate step, aiming at obtaining the required technical basis and human resources. The Basic Technology Accelerator with the energy of 10 MeV and with the current of ∼10 mA is composed of the ion source, RFQ and DTL, of which system forms the mock-up of the injector of ETA. Development of the high-β structure which constitutes the main acceleration part of ETA is also scheduled. This report covers the basic parameters of the Basic Technology Accelerator (BTA), development steps of the element and system technologies of the high current accelerators and rough sketch of ETA which can be prospected at present. (J.P.N.)

PGC-1{alpha} accelerates cytosolic Ca{sup 2+} clearance without disturbing Ca{sup 2+} homeostasis in cardiac myocytes

Energy Technology Data Exchange (ETDEWEB)

Chen, Min, E-mail: chenminyx@gmail.com [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Yunnan Centers for Diseases Prevention and Control, Kunming 650022 (China); Wang, Yanru [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Qu, Aijuan [Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States)

2010-06-11

Energy metabolism and Ca{sup 2+} handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1{alpha}) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1{alpha} in cardiac Ca{sup 2+} signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1{alpha} via adenoviral transduction. Our data shows that overexpressing PGC-1{alpha} improved myocyte contractility without increasing the amplitude of Ca{sup 2+} transients, suggesting that myofilament sensitivity to Ca{sup 2+} increased. Interestingly, the decay kinetics of global Ca{sup 2+} transients and Ca{sup 2+} waves accelerated in PGC-1{alpha}-expressing cells, but the decay rate of caffeine-elicited Ca{sup 2+} transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca{sup 2+}-ATPase (SERCA2a), but not Na{sup +}/Ca{sup 2+} exchange (NCX) contribute to PGC-1{alpha}-induced cytosolic Ca{sup 2+} clearance. Furthermore, PGC-1{alpha} induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1{alpha} did not disturb cardiac Ca{sup 2+} homeostasis, because SR Ca{sup 2+} load and the propensity for Ca{sup 2+} waves remained unchanged. These data suggest that PGC-1{alpha} can ameliorate cardiac Ca{sup 2+} cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1{alpha}-calcium handing pathway sheds new light on the role of PGC-1{alpha} in the therapy of cardiac diseases.

High-energy cosmic-ray acceleration

CERN Document Server

Bustamante, M; de Paula, W; Duarte Chavez, J A; Gago, A M; Hakobyan, H; Jez, P; Monroy Montañez, J A; Ortiz Velasquez, A; Padilla Cabal, F; Pino Rozas, M; Rodriguez Patarroyo, D J; Romeo, G L; Saldaña-Salazar , U J; Velasquez, M; von Steinkirch, M

2010-01-01

We briefly review the basics of ultrahigh-energy cosmic-ray acceleration. The Hillas criterion is introduced as a geometrical criterion that must be fulfilled by potential acceleration sites, and energy losses are taken into account in order to obtain a more realistic scenario. The different available acceleration mechanisms are presented, with special emphasis on Fermi shock acceleration and its prediction of a power-law cosmic-ray energy spectrum. We conclude that first-order Fermi acceleration, though not entirely satisfactory, is the most promising mechanism for explaining the ultra-high-energy cosmic-ray flux.

New accelerators in high-energy physics

International Nuclear Information System (INIS)

Blewett, J.P.

1982-01-01

First, I should like to mention a few new ideas that have appeared during the last few years in the accelerator field. A couple are of importance in the design of injectors, usually linear accelerators, for high-energy machines. Then I shall review some of the somewhat sensational accelerator projects, now in operation, under construction or just being proposed. Finally, I propose to mention a few applications of high-energy accelerators in fields other than high-energy physics. I realize that this is a digression from my title but I hope that you will find it interesting

Metabolic and cardiac changes in high cholesterol-fructose-fed rats

DEFF Research Database (Denmark)

Axelsen, Lene N; Pedersen, Henrik D; Petersen, Jørgen S

2010-01-01

Introduction: High cholesterol-fructose (HCF) fed rats have previously been described as an animal model of impaired cardiac insulin signaling and decreased contractile performance. In this study, we evaluated the metabolic and cardiac effects of a HCF diet in rats. Methods: Male Sprague-Dawley r......Introduction: High cholesterol-fructose (HCF) fed rats have previously been described as an animal model of impaired cardiac insulin signaling and decreased contractile performance. In this study, we evaluated the metabolic and cardiac effects of a HCF diet in rats. Methods: Male Sprague...

Acceleration of polarized proton in high energy accelerators

International Nuclear Information System (INIS)

Lee, S.Y.

1991-01-01

In low to medium energy accelerators, betatron tune jumps and vertical orbit harmonic correction methods have been used to overcome the intrinsic and imperfection resonances. At high energy accelerators, snakes are needed to preserve polarization. The author analyzes the effects of snake resonances, snake imperfections, and overlapping resonances on spin depolarization. He discusses also results of recent snake experiments at the IUCF Cooler Ring. The snake can overcome various kinds of spin depolarization resonances. These experiments pointed out further that partial snake can be used to cure the imperfection resonances in low to medium energy accelerators

Highly accelerated cardiac cine parallel MRI using low-rank matrix completion and partial separability model

Science.gov (United States)

Lyu, Jingyuan; Nakarmi, Ukash; Zhang, Chaoyi; Ying, Leslie

2016-05-01

This paper presents a new approach to highly accelerated dynamic parallel MRI using low rank matrix completion, partial separability (PS) model. In data acquisition, k-space data is moderately randomly undersampled at the center kspace navigator locations, but highly undersampled at the outer k-space for each temporal frame. In reconstruction, the navigator data is reconstructed from undersampled data using structured low-rank matrix completion. After all the unacquired navigator data is estimated, the partial separable model is used to obtain partial k-t data. Then the parallel imaging method is used to acquire the entire dynamic image series from highly undersampled data. The proposed method has shown to achieve high quality reconstructions with reduction factors up to 31, and temporal resolution of 29ms, when the conventional PS method fails.

High-current proton accelerators-meson factories

International Nuclear Information System (INIS)

Dmitrievskij, V.P.

1979-01-01

A possibility of usage of accelerators of neutron as well as meson factories is considered. Parameters of linear and cyclic accelerators are given, which are employed as meson factories and as base for developing intense neutron generators. It is emphasized that the principal aim of developing neutron generators on the base of high current proton accelerators is production of intense neutron fluxes with a present energy spectrum. Production of tens-and-hundreds milliampere currents at the energy of 800-1000 MeV is considered at present for two types of accelerating facilities viz. linear accelerators under continuous operating conditions and cyclotrons with strong focusing. Quantitative evaluations of developing high-efficiency linear and cyclic accelerators are considered. The basic parameters of an ccelerating complex are given, viz. linear accelerator-injector and 800 MeV isochronous cyclotron. The main problems associated with their realization are listed [ru

Ultra-high vacuum photoelectron linear accelerator

Science.gov (United States)

Yu, David U.L.; Luo, Yan

2013-07-16

An rf linear accelerator for producing an electron beam. The outer wall of the rf cavity of said linear accelerator being perforated to allow gas inside said rf cavity to flow to a pressure chamber surrounding said rf cavity and having means of ultra high vacuum pumping of the cathode of said rf linear accelerator. Said rf linear accelerator is used to accelerate polarized or unpolarized electrons produced by a photocathode, or to accelerate thermally heated electrons produced by a thermionic cathode, or to accelerate rf heated field emission electrons produced by a field emission cathode.

Development of high intensity proton accelerator

International Nuclear Information System (INIS)

Mizumoto, M.; Kusano, J.; Hasegawa, K.; Ouchi, N.; Oguri, H.; Kinsho, M.; Touchi, Y.; Honda, Y.; Mukugi, K.; Ino, H.; Noda, F.; Akaoka, N.; Kaneko, H.; Chishiro, E.; Fechner, B.

1997-01-01

The high-intensity proton linear accelerator with an energy of 1.5 GeV and an average current of 5.33mA has been proposed for the Neutron Science Project (NSP) at JAERI. the NSP is aiming at exploring nuclear technologies for nuclear waste transmutation based on a proton induced spallation neutrons. The proposed accelerators facilities will be also used in the various basic research fields such as condensed matter physics in combination with a high intensity proton storage ring. The R and D work has been carried out for the components of the front-end of the proton accelerator. For the high energy portion above 100 MeV, superconducting (SC) accelerator linac has been designed and developed as a major option. (Author) 7 refs

HIGH-GRADIENT, HIGH-TRANSFORMER-RATIO, DIELECTRIC WAKE FIELD ACCELERATOR

Energy Technology Data Exchange (ETDEWEB)

Hirshfield, Jay L

2012-04-12

The Phase I work reported here responds to DoE'ss stated need "...to develop improved accelerator designs that can provide very high gradient (>200 MV/m for electrons...) acceleration of intense bunches of particles." Omega-P's approach to this goal is through use of a ramped train of annular electron bunches to drive a coaxial dielectric wakefield accelerator (CDWA) structure. This approach is a direct extension of the CDWA concept from acceleration in wake fields caused by a single drive bunch, to the more efficient acceleration that we predict can be realized from a tailored (or ramped) train of several drive bunches. This is possible because of a much higher transformer ratio for the latter. The CDWA structure itself has a number of unique features, including: a high accelerating gradient G, potentially with G > 1 GeV/m; continuous energy coupling from drive to test bunches without transfer structures; inherent transverse focusing forces for particles in the accelerated bunch; highly stable motion of high charge annular drive bunches; acceptable alignment tolerances for a multi-section system. What is new in the present approach is that the coaxial dielectric structure is now to be energized by-not one-but by a short train of ramped annular-shaped drive bunches moving in the outer coaxial channel of the structure. We have shown that this allows acceleration of an electron bunch traveling along the axis in the inner channel with a markedly higher transformer ratio T than for a single drive bunch. As described in this report, the structure will be a GHz-scale prototype with cm-scale transverse dimensions that is expected to confirm principles that can be applied to the design of a future THz-scale high gradient (> 500 MV/m) accelerator with mm-scale transverse dimensions. We show here a new means to significantly increase the transformer ratio T of the device, and thereby to significantly improve its suitability as a flexible and effective component in

Accuracy of accelerated cine MR imaging at 3 Tesla in longitudinal follow-up of cardiac function

International Nuclear Information System (INIS)

Sandner, Torleif A.; Huber, Armin M.; Theisen, Daniel; Reiser, Maximilian F.; Wintersperger, Bernd J.; Houck, Philip; Runge, Val M.; Sincleair, Spencer

2008-01-01

The ability of fast, parallel-imaging-based cine magnetic resonance (MR) to monitor global cardiac function in longitudinal exams at 3 Tesla was evaluated. Seventeen patients with chronic cardiac disease underwent serial cine MR imaging exams (n=3) at 3 Tesla. Data were acquired in short-axis orientation using cine steady-state free precession (SSFP) with a spatial resolution of 2.5 x 1.9 mm 2 at 45 ms temporal resolution. Multislice imaging (three slices/breath-hold) was performed using TSENSE acceleration (R=3) and standard single-slice cine (non-TSENSE) was performed at identical locations in consecutive breath-holds. End-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF) and myocardial mass (MM) of both cine approaches were compared for individual time-points as well as for longitudinal comparison. TSENSE-cine did not show significant differences for EDV (2.6 ml; P=.79), ESV (2.2 ml; P=0.81), EF (-0.3%; P=0.95) and MM (2.4 g; P=0.72) in comparison with non-TSENSE. Longitudinal ANOVA analysis did not reveal significant differences for any parameter, neither for non-TSENSE data (all P>0.7) nor for TSENSE data (all P>0.9). Multifactorial ANOVA showed non-significant differences (all P>0.7) at comparable data variances. Data acquisition was significantly shortened using TSENSE. Threefold accelerated multislice cine at 3 Tesla allows accurate assessment of volumetric LV data and accurate longitudinal monitoring of global LV function at a substantially shorter overall examination time. (orig.)

Very high pulse-energy accelerators

International Nuclear Information System (INIS)

Ramirez, J.J.

1989-01-01

The dominant trend in the development of pulsed power accelerator technology over the last decade has been towards higher power and shorter pulse widths. Limitations in high voltage, high current switch performance, and in power flow through vacuum insulator housings led to the development of highly modular designs. This modular approach requires precise synchronization of the various modules and efficient methods of combining the power from these modules to drive a common load. The need to drive very low impedance loads led to effective ways to combine these modules in parallel. The Particle Beam Fusion Accelerator I (PBFA I) and Saturn are representative of these designs. Hermes III represent a new approach towards the efficient generation of higher voltages. It is designed to drive a 22-MV, 730-kA, 40-ns electron beam diode and combines conventional, modular pulsed power technology with linear induction accelerator concepts. High-power induction accelerator cavities are combined with voltage addition along a MITL to generate the desired output. This design differs from a conventional linac in that the voltages are added by the MITL flow rather than by a drifting beam that gains kinetic energy at each stage. This design is a major extrapolation of previous state-of-the-art technology represented by the injector module of the Advanced Test Accelerator and has proven to be efficient and reliable. The design and performance of Hermes III are presented together with a discussion of the application of this technology to the light ion beam inertial confinement fusion program. 18 refs., 9 figs

High energy particle accelerators as radiation Sources

Energy Technology Data Exchange (ETDEWEB)

Abdelaziz, M E [National Center for Nuclear Safety and Radiation Vontrol, Atomic Energy Authority, Cairo (Egypt)

1997-12-31

Small accelerators in the energy range of few million electron volts are usually used as radiation sources for various applications, like radiotherapy, food irradiation, radiation sterilization and in other industrial applications. High energy accelerators with energies reaching billions of electron volts also find wide field of applications as radiation sources. Synchrotrons with high energy range have unique features as radiation sources. This review presents a synopsis of cyclic accelerators with description of phase stability principle of high energy accelerators with emphasis on synchrotrons. Properties of synchrotron radiation are given together with their applications in basic and applied research. 13 figs.,1 tab.

High energy medical accelerators

International Nuclear Information System (INIS)

Mandrillon, P.

1990-01-01

The treatment of tumours with charged particles, ranging from protons to 'light ions' (carbon, oxygen, neon), has many advantages, but up to now has been little used because of the absence of facilities. After the successful pioneering work carried out with accelerators built for physics research, machines dedicated to this new radiotherapy are planned or already in construction. These high energy medical accelerators are presented in this paper. (author) 15 refs.; 14 figs.; 8 tabs

High intensity hadron accelerators

International Nuclear Information System (INIS)

Teng, L.C.

1989-05-01

This rapporteur report consists mainly of two parts. Part I is an abridged review of the status of all High Intensity Hadron Accelerator projects in the world in semi-tabulated form for quick reference and comparison. Part II is a brief discussion of the salient features of the different technologies involved. The discussion is based mainly on my personal experiences and opinions, tempered, I hope, by the discussions I participated in in the various parallel sessions of the workshop. In addition, appended at the end is my evaluation and expression of the merits of high intensity hadron accelerators as research facilities for nuclear and particle physics

A Statistical Perspective on Highly Accelerated Testing

Energy Technology Data Exchange (ETDEWEB)

Thomas, Edward V. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-02-01

Highly accelerated life testing has been heavily promoted at Sandia (and elsewhere) as a means to rapidly identify product weaknesses caused by flaws in the product's design or manufacturing process. During product development, a small number of units are forced to fail at high stress. The failed units are then examined to determine the root causes of failure. The identification of the root causes of product failures exposed by highly accelerated life testing can instigate changes to the product's design and/or manufacturing process that result in a product with increased reliability. It is widely viewed that this qualitative use of highly accelerated life testing (often associated with the acronym HALT) can be useful. However, highly accelerated life testing has also been proposed as a quantitative means for "demonstrating" the reliability of a product where unreliability is associated with loss of margin via an identified and dominating failure mechanism. It is assumed that the dominant failure mechanism can be accelerated by changing the level of a stress factor that is assumed to be related to the dominant failure mode. In extreme cases, a minimal number of units (often from a pre-production lot) are subjected to a single highly accelerated stress relative to normal use. If no (or, sufficiently few) units fail at this high stress level, some might claim that a certain level of reliability has been demonstrated (relative to normal use conditions). Underlying this claim are assumptions regarding the level of knowledge associated with the relationship between the stress level and the probability of failure. The primary purpose of this document is to discuss (from a statistical perspective) the efficacy of using accelerated life testing protocols (and, in particular, "highly accelerated" protocols) to make quantitative inferences concerning the performance of a product (e.g., reliability) when in fact there is lack-of-knowledge and uncertainty concerning

[Statocyst regulation of the heart and statokinetic reflexes in the crab, Hemigrapsus sanguineus, during linear acceleration].

Science.gov (United States)

Kuntsova, M Ia; Sveshnikov, V G; Timofeeva, E V

1978-01-01

In experiments on the shore crab H. sanguineus studies have been made of the effect of variable longitudinal acceleration during swinging (for 15--30 min) upon cardiac activity and gravitational reflexes. High sensitivity of gravitational receptors of the canal statocyst to the effect of acceleration was demonstrated. Removal of the statocysts increases the frequency and amplitude of cardiac contractions as revealed by ECG recording. Changes in stato-kinetic coordinations cause both the disorder of overturning reactions and the disorder of reciprocal inhibition in antagonistic muscles of the dactylopodite. Statocyst regulation of skeletal muscles and heart is presumably realised via contralateral inhibitory canal which is sensitive to linear accelerations.

High energy plasma accelerators

International Nuclear Information System (INIS)

Tajima, T.

1985-05-01

Colinear intense laser beams ω 0 , kappa 0 and ω 1 , kappa 1 shone on a plasma with frequency separation equal to the electron plasma frequency ω/sub pe/ are capable of creating a coherent large longitudinal electric field E/sub L/ = mc ω/sub pe//e of the order of 1GeV/cm for a plasma density of 10 18 cm -3 through the laser beat excitation of plasma oscillations. Accompanying favorable and deleterious physical effects using this process for a high energy beat-wave accelerator are discussed: the longitudinal dephasing, pump depletion, the transverse laser diffraction, plasma turbulence effects, self-steepening, self-focusing, etc. The basic equation, the driven nonlinear Schroedinger equation, is derived to describe this system. Advanced accelerator concepts to overcome some of these problems are proposed, including the plasma fiber accelerator of various variations. An advanced laser architecture suitable for the beat-wave accelerator is suggested. Accelerator physics issues such as the luminosity are discussed. Applications of the present process to the current drive in a plasma and to the excitation of collective oscillations within nuclei are also discussed

Relativistic klystrons for high-gradient accelerators

International Nuclear Information System (INIS)

Westenskow, G.A.; Aalberts, D.P.; Boyd, J.K.; Deis, G.A.; Houck, T.L.; Orzechowski, T.J.; Ryne, R.D.; Yu, S.S.; Allen, M.A.; Callin, R.S.; Deruyter, H.; Eppley, K.R.; Fant, K.S.; Fowkes, W.R.; Hoag, H.A.; Koontz, R.F.; Lavine, T.L.; Loew, G.A.; Miller, R.H.; Ruth, R.D.; Vlieks, A.E.; Wang, J.W.; Hopkins, D.B.; Sessler, A.M.; Haimson, J.; Mecklenburg, B.

1991-01-01

Experimental work is being performed by collaborators at LLNL, SLAC, and LBL to investigate relativistic klystrons as a possible rf power source for future high-gradient accelerators. The authors have learned how to overcome their previously reported problem of high power rf pulse shortening and have achieved peak rf power levels of 330 MW using an 11.4-GHz high-gain tube with multiple output structures. In these experiments the rf pulse is of the same duration as the beam current pulse. In addition, experiments have been performed on two short sections of a high-gradient accelerator using the rf power from a relativistic klystron. An average accelerating gradient of 84 MV/m has been achieved with 80-MW of rf power

Applications of High Intensity Proton Accelerators

Science.gov (United States)

Raja, Rajendran; Mishra, Shekhar

2010-06-01

Superconducting radiofrequency linac development at Fermilab / S. D. Holmes -- Rare muon decay experiments / Y. Kuno -- Rare kaon decays / D. Bryman -- Muon collider / R. B. Palmer -- Neutrino factories / S. Geer -- ADS and its potential / J.-P. Revol -- ADS history in the USA / R. L. Sheffield and E. J. Pitcher -- Accelerator driven transmutation of waste: high power accelerator for the European ADS demonstrator / J. L. Biarrotte and T. Junquera -- Myrrha, technology development for the realisation of ADS in EU: current status & prospects for realisation / R. Fernandez ... [et al.] -- High intensity proton beam production with cyclotrons / J. Grillenberger and M. Seidel -- FFAG for high intensity proton accelerator / Y. Mori -- Kaon yields for 2 to 8 GeV proton beams / K. K. Gudima, N. V. Mokhov and S. I. Striganov -- Pion yield studies for proton driver beams of 2-8 GeV kinetic energy for stopped muon and low-energy muon decay experiments / S. I. Striganov -- J-Parc accelerator status and future plans / H. Kobayashi -- Simulation and verification of DPA in materials / N. V. Mokhov, I. L. Rakhno and S. I. Striganov -- Performance and operational experience of the CNGS facility / E. Gschwendtner -- Particle physics enabled with super-conducting RF technology - summary of working group 1 / D. Jaffe and R. Tschirhart -- Proton beam requirements for a neutrino factory and muon collider / M. S. Zisman -- Proton bunching options / R. B. Palmer -- CW SRF H linac as a proton driver for muon colliders and neutrino factories / M. Popovic, C. M. Ankenbrandt and R. P. Johnson -- Rapid cycling synchrotron option for Project X / W. Chou -- Linac-based proton driver for a neutrino factory / R. Garoby ... [et al.] -- Pion production for neutrino factories and muon colliders / N. V. Mokhov ... [et al.] -- Proton bunch compression strategies / V. Lebedev -- Accelerator test facility for muon collider and neutrino factory R&D / V. Shiltsev -- The superconducting RF linac for muon

Accelerated dynamic cardiac MRI exploiting sparse-Kalman-smoother self-calibration and reconstruction (k  −  t SPARKS)

International Nuclear Information System (INIS)

Park, Suhyung; Park, Jaeseok

2015-01-01

Accelerated dynamic MRI, which exploits spatiotemporal redundancies in k  −  t space and coil dimension, has been widely used to reduce the number of signal encoding and thus increase imaging efficiency with minimal loss of image quality. Nonetheless, particularly in cardiac MRI it still suffers from artifacts and amplified noise in the presence of time-drifting coil sensitivity due to relative motion between coil and subject (e.g. free breathing). Furthermore, a substantial number of additional calibrating signals is to be acquired to warrant accurate calibration of coil sensitivity. In this work, we propose a novel, accelerated dynamic cardiac MRI with sparse-Kalman-smoother self-calibration and reconstruction (k  −  t SPARKS), which is robust to time-varying coil sensitivity even with a small number of calibrating signals. The proposed k  −  t SPARKS incorporates Kalman-smoother self-calibration in k  −  t space and sparse signal recovery in x  −   f space into a single optimization problem, leading to iterative, joint estimation of time-varying convolution kernels and missing signals in k  −  t space. In the Kalman-smoother calibration, motion-induced uncertainties over the entire time frames were included in modeling state transition while a coil-dependent noise statistic in describing measurement process. The sparse signal recovery iteratively alternates with the self-calibration to tackle the ill-conditioning problem potentially resulting from insufficient calibrating signals. Simulations and experiments were performed using both the proposed and conventional methods for comparison, revealing that the proposed k  −  t SPARKS yields higher signal-to-error ratio and superior temporal fidelity in both breath-hold and free-breathing cardiac applications over all reduction factors. (paper)

The evolution of high energy accelerators

International Nuclear Information System (INIS)

Courant, E.D.

1994-01-01

Accelerators have been devised and built for two reasons: In the first place, by physicists who needed high energy particles in order to have a means to explore the interactions between particles that probe the fundamental elementary forces of nature. And conversely, sometimes accelerator builders produce new machines for higher energy than ever before just because it can be done, and then challenge potential users to make new discoveries with the new means at hand. These two approaches or motivations have gone hand in hand. This lecture traces how high energy particle accelerators have grown from tools used for esoteric small-scale experiments to the gigantic projects of today. So far all the really high-energy machines built and planned in the world--except the SLC--have been ring accelerators and storage rings using the strong-focusing method. But this method has not removed the energy limit, it has only pushed it higher. It would seem unlikely that one can go beyond the Large Hadron Collider (LHC)--but in fact a workshop was held in Sicily in November 1991, concerned with the question of extrapolating to 100 TeV. Other acceleration and beam-forming methods are now being discussed--collective fields, laser acceleration, wake-field accelerators etc., all aimed primarily at making linear colliders possible and more attractive than with present radiofrequency methods. So far it is not entirely clear which of these schemes will dominate particle physics in the future--maybe something that has not been thought of as yet

Accelerator System Development at High Voltage Engineering

International Nuclear Information System (INIS)

Klein, M. G.; Gottdang, A.; Haitsma, R. G.; Mous, D. J. W.

2009-01-01

Throughout the years, HVE has continuously extended the capabilities of its accelerator systems to meet the rising demands from a diverse field of applications, among which are deep level ion implantation, micro-machining, neutron production for biomedical research, isotope production or accelerator mass spectrometry. Characteristic for HVE accelerators is the coaxial construction of the all solid state power supply around the acceleration tubes. With the use of solid state technology, the accelerators feature high stability and very low ripple. Terminal voltages range from 1 to 6 MV for HVE Singletrons and Tandetrons. The high-current versions of these accelerators can provide ion beams with powers of several kW. In the last years, several systems have been built with terminal voltages of 1.25 MV, 2 MV and 5 MV. Recently, the first system based on a 6 MV Tandetron has passed the factory tests. In this paper we describe the characteristics of the HVE accelerator systems and present as example recent systems.

Dielectric-Lined High-Gradient Accelerator Structure

Energy Technology Data Exchange (ETDEWEB)

Jay L. Hirshfield

2012-04-24

Rectangular particle accelerator structures with internal planar dielectric elements have been studied, with a view towards devising structures with lower surface fields for a given accelerating field, as compared with structures without dielectrics. Success with this concept is expected to allow operation at higher accelerating gradients than otherwise on account of reduced breakdown probabilities. The project involves studies of RF breakdown on amorphous dielectrics in test cavities that could enable high-gradient structures to be built for a future multi-TeV collider. The aim is to determine what the limits are for RF fields at the surfaces of selected dielectrics, and the resulting acceleration gradient that could be achieved in a working structure. The dielectric of principal interest in this study is artificial CVD diamond, on account of its advertised high breakdown field ({approx}2 GV/m for dc), low loss tangent, and high thermal conductivity. Experimental studies at mm-wavelengths on materials and structures for achieving high acceleration gradient were based on the availability of the 34.3 GHz third-harmonic magnicon amplifier developed by Omega-P, and installed at the Yale University Beam Physics Laboratory. Peak power from the magnicon was measured to be about 20 MW in 0.5 {micro}s pulses, with a gain of 54 dB. Experiments for studying RF high-field effects on CVD diamond samples failed to show any evidence after more than 10{sup 5} RF pulses of RF breakdown up to a tangential surface field strength of 153 MV/m; studies at higher fields were not possible due to a degradation in magnicon performance. A rebuild of the tube is underway at this writing. Computed performance for a dielectric-loaded rectangular accelerator structure (DLA) shows highly competitive properties, as compared with an existing all-metal structure. For example, comparisons were made of a DLA structure having two planar CVD diamond elements with a all-metal CERN structure HDS

Dielectric-Lined High-Gradient Accelerator Structure

International Nuclear Information System (INIS)

Hirshfield, Jay L.

2012-01-01

Rectangular particle accelerator structures with internal planar dielectric elements have been studied, with a view towards devising structures with lower surface fields for a given accelerating field, as compared with structures without dielectrics. Success with this concept is expected to allow operation at higher accelerating gradients than otherwise on account of reduced breakdown probabilities. The project involves studies of RF breakdown on amorphous dielectrics in test cavities that could enable high-gradient structures to be built for a future multi-TeV collider. The aim is to determine what the limits are for RF fields at the surfaces of selected dielectrics, and the resulting acceleration gradient that could be achieved in a working structure. The dielectric of principal interest in this study is artificial CVD diamond, on account of its advertised high breakdown field (∼2 GV/m for dc), low loss tangent, and high thermal conductivity. Experimental studies at mm-wavelengths on materials and structures for achieving high acceleration gradient were based on the availability of the 34.3 GHz third-harmonic magnicon amplifier developed by Omega-P, and installed at the Yale University Beam Physics Laboratory. Peak power from the magnicon was measured to be about 20 MW in 0.5 (micro)s pulses, with a gain of 54 dB. Experiments for studying RF high-field effects on CVD diamond samples failed to show any evidence after more than 10 5 RF pulses of RF breakdown up to a tangential surface field strength of 153 MV/m; studies at higher fields were not possible due to a degradation in magnicon performance. A rebuild of the tube is underway at this writing. Computed performance for a dielectric-loaded rectangular accelerator structure (DLA) shows highly competitive properties, as compared with an existing all-metal structure. For example, comparisons were made of a DLA structure having two planar CVD diamond elements with a all-metal CERN structure HDS operating at 30

New Pulsed Power Technology for High Current Accelerators

International Nuclear Information System (INIS)

Caporaso, G J

2002-01-01

Recent advances in solid-state modulators now permit the design of a new class of high current accelerators. These new accelerators will be able to operate in burst mode at frequencies of several MHz with unprecedented flexibility and precision in pulse format. These new modulators can drive accelerators to high average powers that far exceed those of any other technology and can be used to enable precision beam manipulations. New insulator technology combined with novel pulse forming lines and switching may enable the construction of a new type of high gradient, high current accelerator. Recent developments in these areas will be reviewed

Chamber-dependent circadian expression of cardiac natriuretic peptides

DEFF Research Database (Denmark)

Gøtze, Jens Peter; Georg, Birgitte; Jørgensen, Henrik L

2010-01-01

Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) have important local functions within the myocardium, where they protect against accelerated fibrosis. As circadian expression of cardiac natriuretic peptides could be of importance in local cardiac protection against disease, we...

Accelerated cardiovascular magnetic resonance of the mouse heart using self-gated parallel imaging strategies does not compromise accuracy of structural and functional measures

Directory of Open Access Journals (Sweden)

Dörries Carola

2010-07-01

Full Text Available Abstract Background Self-gated dynamic cardiovascular magnetic resonance (CMR enables non-invasive visualization of the heart and accurate assessment of cardiac function in mouse models of human disease. However, self-gated CMR requires the acquisition of large datasets to ensure accurate and artifact-free reconstruction of cardiac cines and is therefore hampered by long acquisition times putting high demands on the physiological stability of the animal. For this reason, we evaluated the feasibility of accelerating the data collection using the parallel imaging technique SENSE with respect to both anatomical definition and cardiac function quantification. Results Findings obtained from accelerated data sets were compared to fully sampled reference data. Our results revealed only minor differences in image quality of short- and long-axis cardiac cines: small anatomical structures (papillary muscles and the aortic valve and left-ventricular (LV remodeling after myocardial infarction (MI were accurately detected even for 3-fold accelerated data acquisition using a four-element phased array coil. Quantitative analysis of LV cardiac function (end-diastolic volume (EDV, end-systolic volume (ESV, stroke volume (SV, ejection fraction (EF and LV mass in healthy and infarcted animals revealed no substantial deviations from reference (fully sampled data for all investigated acceleration factors with deviations ranging from 2% to 6% in healthy animals and from 2% to 8% in infarcted mice for the highest acceleration factor of 3.0. CNR calculations performed between LV myocardial wall and LV cavity revealed a maximum CNR decrease of 50% for the 3-fold accelerated data acquisition when compared to the fully-sampled acquisition. Conclusions We have demonstrated the feasibility of accelerated self-gated retrospective CMR in mice using the parallel imaging technique SENSE. The proposed method led to considerably reduced acquisition times, while preserving high

Multistage charged particle accelerator, with high-vacuum insulation

International Nuclear Information System (INIS)

Holl, P.

1976-01-01

A multistage charged-particle accelerator for operating with accelerating voltages higher than 150 kV is described. The device consists essentially of a high-voltage insulator, a source for producing charged particles, a Wehnelt cylinder, an anode, and a post-accelerating tube containing stack-wise positioned post-accelerating electrodes. A high vacuum is used for insulating the parts carrying the high voltages, and at least one cylindrical screen surrounding these parts is interposed between them and the vacuum vessel, which can itself also function as a cylindrical screen

High power electron accelerators for flue gas treatment

International Nuclear Information System (INIS)

Zimek, Z.

2011-01-01

Flue gas treatment process based on electron beam application for SO 2 and NO x removal was successfully demonstrated in number of laboratories, pilot plants and industrial demonstration facilities. The industrial scale application of an electron beam process for flue gas treatment requires accelerators modules with a beam power 100-500 kW and electron energy range 0.8-1.5 MeV. The most important accelerator parameters for successful flue gas radiation technology implementation are related to accelerator reliability/availability, electrical efficiency and accelerator price. Experience gained in high power accelerators exploitation in flue gas treatment industrial demonstration facility was described and high power accelerator constructions have been reviewed. (author)

Development of a high intensity proton accelerator

International Nuclear Information System (INIS)

Mizumoto, Motoharu; Kusano, Joichi; Hasegawa, Kazuo; Ito, Nobuo; Oguri, Hidetomo; Touchi, Yutaka; Mukugi, Ken; Ino, Hiroshi

1997-01-01

The high-intensity proton linear accelerator with a beam power of 15 MW has been proposed for various engineering tests for the nuclear waste transmutation system as one of the research plans in the Neutron Science Research Program (NSRP) in JAERI. High intensity proton beam and secondary particle beams such as neutron, pion, muon and unstable radio isotope (RI) beam generated from the proton spallation reaction will be utilized at these facilities in each research field. The R and D work has been carried out for the components of the front-end part of the proton accelerator; ion source, RFQ, DTL and RF source. In the beam test, the current of 70 mA with a duty factor of 7% has been accelerated from the RFQ at the energy of 2 MeV. A hot test model of the DTL for the high power and high duty operation was fabricated and tested. For the high energy portion above 100 MeV, superconducting accelerating cavity is studied as a main option. The superconducting linac is expected to have several favourable characteristics for high intensity accelerator such as short accelerator length, large bore radius resulting in low beam losses and cost effectiveness for construction and operation. A test stand with equipment of cryogenics system, vacuum system, RF system and cavity processing and cleaning is prepared to test the physics issues and fabrication process. The proposed plan for accelerator design and construction will compose of two consecutive stages. The first stage will be completed in about 7 years with the beam power of 1.5 MW. As the second stage gradual upgrading of the beam power will be made up to 15 MW. 7 refs., 3 figs., 4 tabs

High-brightness H/sup -/ accelerators

International Nuclear Information System (INIS)

Jameson, R.A.

1987-01-01

Neutral particle beam (NPB) devices based on high-brightness H/sup -/ accelerators are an important component of proposed strategic defense systems. The basic rational and R and D program are outlined and examples given of the underlying technology thrusts toward advanced systems. Much of the research accomplished in the past year is applicable to accelerator systems in general; some of these activities are discussed

Frequency of cardiac arrhythmias in high and low- yielding dairy cows

Directory of Open Access Journals (Sweden)

Afshin Jafari Dehkordi

2014-06-01

Full Text Available Electrocardiography (ECG may be used to recognize cardiac disorders. Levels of milk production may change the serum electrolytes which its imbalance has a role in cardiac arrhythmia. Fifty high yielding and fifty low yielding Holstein dairy cows were used in this study. Electrocardiography was recorded by base-apex lead and blood samples were collected from jugular vein for measurement of serum elements such as sodium, potassium, calcium, phosphorous, iron and magnesium. Cardiac dysrhythmias were detected more frequent in low yielding Holstein cows (62.00% compared to high yielding Holstein cows (46.00%. The cardiac dysrhythmias that were observed in low yielding Holstein cows included sinus arrhythmia (34.70%, wandering pacemaker (22.45 %, bradycardia (18.37%, tachycardia (10.20%, atrial premature beat (2.04%, sinoatrial block (2.04%, atrial fibrillation (8.16% and atrial tachycardia (2.04%. The cardiac dysrhythmias were observed in high yielding Holstein cows including, sinus arrhythmia (86.95% and wandering pacemaker (13.05%. Also, notched P wave was observed to be 30% and 14% in high- and low- yielding Holstein cows respectively. The serum calcium concentration of low yielding Holstein cows was significantly lower than that of high yielding Holstein cows. There was not any detectable significant difference in other serum elements between high- and low- yielding Holstein cows. Based on the result of present study, could be concluded that low serum concentration of calcium results to more frequent dysrhythmias in low yielding Holstein cows.

High power electron accelerators for flue gas treatment

Energy Technology Data Exchange (ETDEWEB)

Zimek, Z. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

2011-07-01

Flue gas treatment process based on electron beam application for SO{sub 2} and NO{sub x} removal was successfully demonstrated in number of laboratories, pilot plants and industrial demonstration facilities. The industrial scale application of an electron beam process for flue gas treatment requires accelerators modules with a beam power 100-500 kW and electron energy range 0.8-1.5 MeV. The most important accelerator parameters for successful flue gas radiation technology implementation are related to accelerator reliability/availability, electrical efficiency and accelerator price. Experience gained in high power accelerators exploitation in flue gas treatment industrial demonstration facility was described and high power accelerator constructions have been reviewed. (author)

Acceleration of a high-current single bunch in a linear accelerator

International Nuclear Information System (INIS)

Takeda, Seishi

1984-01-01

Some problems associated with the feasibility of an electron-positron linear collider with colliding energy of about 1x1 TeV are discussed. The first problem is related to the generation of high-current single bunch. A quasi-relativistic electron beam from an electron gun is injected into one bucket of the accelerating fields, in opposition to the longitudinal defocusing due to the space-charge effect. For generating a high-current single bunch, the beam bunching by means of the velocity modulation with a subharmonic prebuncher (SHPB) is indispensable. Three existing second generation single bunch electron linear accelerators (SLC, ANL and ISLR-Osaka Univ.) are briefly described. The results of the simulation of subharmonic-bunching is also reported. The second problem is associated with the physics of accelerating high-current single bunch. The longitudinal and transverse wake fields generated by a bunch-cavity interaction and the energy spread of the single bunch are analyzed and discussed. (Aoki, K.)

Fast acceleration of 2D wave propagation simulations using modern computational accelerators.

Directory of Open Access Journals (Sweden)

Wei Wang

Full Text Available Recent developments in modern computational accelerators like Graphics Processing Units (GPUs and coprocessors provide great opportunities for making scientific applications run faster than ever before. However, efficient parallelization of scientific code using new programming tools like CUDA requires a high level of expertise that is not available to many scientists. This, plus the fact that parallelized code is usually not portable to different architectures, creates major challenges for exploiting the full capabilities of modern computational accelerators. In this work, we sought to overcome these challenges by studying how to achieve both automated parallelization using OpenACC and enhanced portability using OpenCL. We applied our parallelization schemes using GPUs as well as Intel Many Integrated Core (MIC coprocessor to reduce the run time of wave propagation simulations. We used a well-established 2D cardiac action potential model as a specific case-study. To the best of our knowledge, we are the first to study auto-parallelization of 2D cardiac wave propagation simulations using OpenACC. Our results identify several approaches that provide substantial speedups. The OpenACC-generated GPU code achieved more than 150x speedup above the sequential implementation and required the addition of only a few OpenACC pragmas to the code. An OpenCL implementation provided speedups on GPUs of at least 200x faster than the sequential implementation and 30x faster than a parallelized OpenMP implementation. An implementation of OpenMP on Intel MIC coprocessor provided speedups of 120x with only a few code changes to the sequential implementation. We highlight that OpenACC provides an automatic, efficient, and portable approach to achieve parallelization of 2D cardiac wave simulations on GPUs. Our approach of using OpenACC, OpenCL, and OpenMP to parallelize this particular model on modern computational accelerators should be applicable to other

Prototyping high-gradient mm-wave accelerating structures

International Nuclear Information System (INIS)

Nanni, Emilio A.; Dolgashev, Valery A.; Haase, Andrew; Neilson, Jeffrey; Tantawi, Sami

2017-01-01

We present single-cell accelerating structures designed for high-gradient testing at 110 GHz. The purpose of this work is to study the basic physics of ultrahigh vacuum RF breakdown in high-gradient RF accelerators. The accelerating structures are π-mode standing-wave cavities fed with a TM 01 circular waveguide. The structures are fabricated using precision milling out of two metal blocks, and the blocks are joined with diffusion bonding and brazing. The impact of fabrication and joining techniques on the cell geometry and RF performance will be discussed. First prototypes had a measured Q 0 of 2800, approaching the theoretical design value of 3300. The geometry of these accelerating structures are as close as practical to singlecell standing-wave X-band accelerating structures more than 40 of which were tested at SLAC. This wealth of X-band data will serve as a baseline for these 110 GHz tests. Furthermore, the structures will be powered with short pulses from a MW gyrotron oscillator. RF power of 1 MW may allow an accelerating gradient of 400 MeV/m to be reached.

High Field Studies for CLIC Accelerating Structures Development

CERN Document Server

Profatilova, I

2017-01-01

Compact Linear Collider RF structures need to be able to achieve the very high average accelerating gradient of 100 MV/m. One of the main challenges in reaching such high accelerating gradients is to avoid vacuum electrical breakdown within CLIC accelerating structures. Accelerating structure tests are carried out in the klystron-based test stands known as the XBoxes. In order to investigate vacuum breakdown phenomena and its statistical characteristics in a simpler system and get results in a faster way, pulsed dc systems have been developed at CERN. To acquire sufficient breakdown data in a reasonable period of time, high repetition rate pulse generators are used in the systems for breakdown studies, so-called pulsed dc system. This paper describes the pulsed dc systems and the two high repetition rate circuits, which produce high-voltage pulses for it, available at CERN.

Accelerator technical design report for high-intensity proton accelerator facility project, J-PARC

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-03-01

This report presents the detail of the technical design of the accelerators for the High-Intensity Proton Accelerator Facility Project, J-PARC. The accelerator complex comprises a 400-MeV room-temperature linac (600-MeV superconducting linac), 3-GeV rapid-cycling synchrotron (RCS), and a 50-GeV synchrotron (MR). The 400-MeV beam is injected to the RCS, being accelerated to 3 GEV. The 1-MW beam thus produced is guided to the Materials Life Science Experimental Facility, with both the pulsed spallation neutron source and muon source. A part of the beam is transported to the MR, which provides the 0.75-MW beam to either the Nuclear and Fundamental Particle Experimental Facility or the Neutrino Production Target. On the other hand, the beam accelerated to 600 MeV by the superconducting linac is used for the Nuclear Waster Transmutation Experiment. In this way, this facility is unique, being multipurpose one, including many new inventions and Research and Development Results. This report is based upon the accomplishments made by the Accelerator Group and others of the Project Team, which is organized on the basis of the Agreement between JAERI and KEK on the Construction and Research and Development of the High-Intensity Proton Accelerator Facility. (author)

The high energy accelerator program in Japan

International Nuclear Information System (INIS)

Ozaki, S.

1987-01-01

The author observes that in order to survey the intentions of Japanese high energy physicists and to make a recommendation to the High Energy Committee on future plans for high energy physics in Japan, including accelerators after TRISTAN, international collaboration projects and non-accelerator physics, a subcommittee of fifteen members is formed. The committee recommendation reads: A) For a new energy frontier, 1. Immediate initiation of R/D efforts for an e/sup +/e/sup -/ linear collider of TeV class, constructs a possible home-based facility, 2. Promotes international collaborative experiments using the SSC for the hadron sector, B) As projects of immediate concern: 1. The energy of the TRISTAN main ring increases further makes a possible low energy, high luminosity e/sup +/e/sup -/ collider operation in the TRISTAN complex, 2. The intensity of the 12 GeV PS at KEK increases, 3. Experiments in non-accelerator particle physics are promoted. In this contribution, the current status of the TRISTAN project and some of the R/D program on accelerator technology are reported

Three-dimensional cardiac cine imaging using the kat ARC acceleration: Initial experience in clinical adult patients at 3T.

Science.gov (United States)

Okuda, Shigeo; Yamada, Yoshitake; Tanimoto, Akihiro; Fujita, Jun; Sano, Motoaki; Fukuda, Keiichi; Kuribayashi, Sachio; Jinzaki, Masahiro; Nozaki, Atsushi; Lai, Peng

2015-09-01

Three-dimensional cardiac cine imaging has demonstrated promising clinical 1.5-Tesla results; however, its application to 3T scanners has been limited because of the higher sensitivity to off-resonance artifacts. The aim of this study was to apply 3D cardiac cine imaging during a single breath hold in clinical patients on a 3T scanner using the kat ARC (k- and adaptive-t auto-calibrating reconstruction for Cartesian sampling) technique and to evaluate the interchangeability between 2D and 3D cine imaging for cardiac functional analysis and detection of abnormalities in regional wall motion. Following institutional review board approval, we obtained 2D cine images with an acceleration factor of two during multiple breath holds and 3D cine images with a net scan acceleration factor of 7.7 during a single breath hold in 20 patients using a 3T unit. Two readers independently evaluated the wall motion of the left ventricle (LV) using a 5-point scale, and the consistency in the detection of regional wall motion abnormality between 2D and 3D cine was analyzed by Cohen's kappa test. The LV volume was calculated at end-diastole and end-systole (LVEDV, LVESV); the ejection fraction (LVEF) and myocardial weight (LVmass) were also calculated. The relationship between functional parameters calculated for 2D and 3D cine images was analyzed using Pearson's correlation analysis. The bias and 95% limit of agreement (LA) were calculated using Bland-Altman plots. In addition, a qualitative evaluation of image quality was performed with regard to the myocardium-blood contrast, noise level and boundary definition. Despite slight degradation in image quality for 3D cine, excellent agreement was obtained for the detection of wall motion abnormalities between 2D and 3D cine images (κ=0.84 and 0.94 for each reader). Excellent correlations between the two imaging methods were shown for the evaluation of functional parameters (r>0.97). Slight differences in LVEDV, LVESV, LVEF and LVmass

High-energy accelerators in medicine

CERN Document Server

Mandrillon, Pierre

1992-05-04

The treatment of tumours with charged particles, ranging from protons to "light ions" ( Carbon, Oxygen, Neon) has many advantages, but up to now has been little used because of the absence of facilities. After the successful pioneering work carried out with accelerators built for physics research, machines dedicated to this new radiotherapy are planned or already in construction. The rationale for this new radiotherapy, the high energy accelerators and the beam delivery systems are presented in these two lectures.

Reliability of high power electron accelerators for radiation processing

Energy Technology Data Exchange (ETDEWEB)

Zimek, Z. [Department of Radiation Chemistry and Technology, Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

2011-07-01

Accelerators applied for radiation processing are installed in industrial facilities where accelerator availability coefficient should be at the level of 95% to fulfill requirements according to industry standards. Usually the exploitation of electron accelerator reviles the number of short and few long lasting failures. Some technical shortages can be overcome by practical implementation the experience gained in accelerator technology development by different accelerator manufactures. The reliability/availability of high power accelerators for application in flue gas treatment process must be dramatically improved to meet industrial standards. Support of accelerator technology dedicated for environment protection should be provided by governmental and international institutions to overcome accelerator reliability/availability problem and high risk and low direct profit in this particular application. (author)

Reliability of high power electron accelerators for radiation processing

International Nuclear Information System (INIS)

Zimek, Z.

2011-01-01

Accelerators applied for radiation processing are installed in industrial facilities where accelerator availability coefficient should be at the level of 95% to fulfill requirements according to industry standards. Usually the exploitation of electron accelerator reviles the number of short and few long lasting failures. Some technical shortages can be overcome by practical implementation the experience gained in accelerator technology development by different accelerator manufactures. The reliability/availability of high power accelerators for application in flue gas treatment process must be dramatically improved to meet industrial standards. Support of accelerator technology dedicated for environment protection should be provided by governmental and international institutions to overcome accelerator reliability/availability problem and high risk and low direct profit in this particular application. (author)

High Power Electron Accelerator Prototype

CERN Document Server

Tkachenko, Vadim; Cheskidov, Vladimir; Korobeynikov, G I; Kuznetsov, Gennady I; Lukin, A N; Makarov, Ivan; Ostreiko, Gennady; Panfilov, Alexander; Sidorov, Alexey; Tarnetsky, Vladimir V; Tiunov, Michael A

2005-01-01

In recent time the new powerful industrial electron accelerators appear on market. It caused the increased interest to radiation technologies using high energy X-rays due to their high penetration ability. However, because of low efficiency of X-ray conversion for electrons with energy below 5 MeV, the intensity of X-rays required for some industrial applications can be achieved only when the beam power exceeds 300 kW. The report describes a project of industrial electron accelerator ILU-12 for electron energy up to 5 MeV and beam power up to 300 kW specially designed for use in industrial applications. On the first stage of work we plan to use the existing generator designed for ILU-8 accelerator. It is realized on the GI-50A triode and provides the pulse power up to 1.5-2 MW and up to 20-30 kW of average power. In the report the basic concepts and a condition of the project for today are reflected.

rf coaxial couplers for high-intensity linear accelerators

International Nuclear Information System (INIS)

Manca, J.J.; Knapp, E.A.

1980-02-01

Two rf coaxial couplers that are particularly suitable for intertank connection of the disk-and-washer accelerating structure for use in high-intensity linear accelerators have been developed. These devices have very high coupling to the accelerating structure and very low rf power loss at the operating frequency, and they can be designed for any relative particle velocity β > 0.4. Focusing and monitoring devices can be located inside these couplers

High-performance computing in accelerating structure design and analysis

International Nuclear Information System (INIS)

Li Zenghai; Folwell, Nathan; Ge Lixin; Guetz, Adam; Ivanov, Valentin; Kowalski, Marc; Lee, Lie-Quan; Ng, Cho-Kuen; Schussman, Greg; Stingelin, Lukas; Uplenchwar, Ravindra; Wolf, Michael; Xiao, Liling; Ko, Kwok

2006-01-01

Future high-energy accelerators such as the Next Linear Collider (NLC) will accelerate multi-bunch beams of high current and low emittance to obtain high luminosity, which put stringent requirements on the accelerating structures for efficiency and beam stability. While numerical modeling has been quite standard in accelerator R and D, designing the NLC accelerating structure required a new simulation capability because of the geometric complexity and level of accuracy involved. Under the US DOE Advanced Computing initiatives (first the Grand Challenge and now SciDAC), SLAC has developed a suite of electromagnetic codes based on unstructured grids and utilizing high-performance computing to provide an advanced tool for modeling structures at accuracies and scales previously not possible. This paper will discuss the code development and computational science research (e.g. domain decomposition, scalable eigensolvers, adaptive mesh refinement) that have enabled the large-scale simulations needed for meeting the computational challenges posed by the NLC as well as projects such as the PEP-II and RIA. Numerical results will be presented to show how high-performance computing has made a qualitative improvement in accelerator structure modeling for these accelerators, either at the component level (single cell optimization), or on the scale of an entire structure (beam heating and long-range wakefields)

Influence of high magnetic field strengths and parallel acquisition strategies on image quality in cardiac 2D CINE magnetic resonance imaging: comparison of 1.5 T vs. 3.0 T

International Nuclear Information System (INIS)

Gutberlet, Matthias; Schwinge, Kerstin; Freyhardt, Patrick; Spors, Birgit; Grothoff, Matthias; Denecke, Timm; Luedemann, Lutz; Felix, Roland; Noeske, Ralph; Niendorf, Thoralf

2005-01-01

The aim of this paper is to examine signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and image quality of cardiac CINE imaging at 1.5 T and 3.0 T. Twenty volunteers underwent cardiac magnetic resonance imaging (MRI) examinations using a 1.5-T and a 3.0-T scanner. Three different sets of breath-held, electrocardiogram-gated (ECG) CINE imaging techniques were employed, including: (1) unaccelerated SSFP (steady state free precession), (2) accelerated SSFP imaging and (3) gradient-echo-based myocardial tagging. Two-dimensional CINE SSFP at 3.0 T revealed an SNR improvement of 103% and a CNR increase of 19% as compared to the results obtained at 1.5 T. The SNR reduction in accelerated 2D CINE SSFP imaging was larger at 1.5 T (37%) compared to 3.0 T (26%). The mean SNR and CNR increase at 3.0 T obtained for the tagging sequence was 88% and 187%, respectively. At 3.0 T, the duration of the saturation bands persisted throughout the entire cardiac cycle. For comparison, the saturation bands were significantly diminished at 1.5 T during end-diastole. For 2D CINE SSFP imaging, no significant difference in the left ventricular volumetry and in the overall image quality was obtained. For myocardial tagging, image quality was significantly improved at 3.0 T. The SNR reduction in accelerated SSFP imaging was overcompensated by the increase in the baseline SNR at 3.0 T and did not result in any image quality degradation. For cardiac tagging techniques, 3.0 T was highly beneficial, which holds the promise to improve its diagnostic value. (orig.)

On the mechanism of high-voltage discharge initiation in high-voltage accelerator accelerating tubes

International Nuclear Information System (INIS)

Zheleznikov, F.G.

1983-01-01

Experimental investigation into physical natupe of discharge processes in high-voltage accelerator accelerating tubes in the absence of the accelerated particle beam are conducted. The installation for the study of the mechanism of initiating vacuum isolation conductivity is used in the experiments. The vacuum chamber of the installation is made of steel and sealed with rubber packings. Electrodes 300-360 mm in diameter are made of stainless steel. Two variants of cleaning technology were used before electrode assembling: 1) degreasing by organic solvents; 2) cleaning by fine grinding cloth with successive washing by rectificated alcohol. Analysis of the obtained data shows that forma. tion of background flux of charged particles in interelectrode gap is caused by external photoelectric effect, excited by X radiation, which initiates the formation of intensive internal field in microfilms of non-conducting impurities on the electrode surfaces. The secondary electron emission plays the minor role at that

Superconductivity in high energy particle accelerators

International Nuclear Information System (INIS)

Schmueser, P.

2002-08-01

The basics of superconductivity are outlined with special emphasis on the features which are relevant for the application in magnets and radio frequency cavities for high energy particle accelerators. The special properties of superconducting accelerator magnets are described in detail: design principles, magnetic field calculations, magnetic forces, quench performance, persistent magnetization currents and eddy currents. The design principles and basic properties of superconducting cavities are explained as well as the observed performance limitations and the countermeasures. The ongoing research efforts towards maximum accelerating fields are addressed and the coupling of radio frequency power to the particle beam is treated. (orig.)

High Energy Density Physics and Exotic Acceleration Schemes

International Nuclear Information System (INIS)

Cowan, T.; Colby, E.

2005-01-01

The High Energy Density and Exotic Acceleration working group took as our goal to reach beyond the community of plasma accelerator research with its applications to high energy physics, to promote exchange with other disciplines which are challenged by related and demanding beam physics issues. The scope of the group was to cover particle acceleration and beam transport that, unlike other groups at AAC, are not mediated by plasmas or by electromagnetic structures. At this Workshop, we saw an impressive advancement from years past in the area of Vacuum Acceleration, for example with the LEAP experiment at Stanford. And we saw an influx of exciting new beam physics topics involving particle propagation inside of solid-density plasmas or at extremely high charge density, particularly in the areas of laser acceleration of ions, and extreme beams for fusion energy research, including Heavy-ion Inertial Fusion beam physics. One example of the importance and extreme nature of beam physics in HED research is the requirement in the Fast Ignitor scheme of inertial fusion to heat a compressed DT fusion pellet to keV temperatures by injection of laser-driven electron or ion beams of giga-Amp current. Even in modest experiments presently being performed on the laser-acceleration of ions from solids, mega-amp currents of MeV electrons must be transported through solid foils, requiring almost complete return current neutralization, and giving rise to a wide variety of beam-plasma instabilities. As keynote talks our group promoted Ion Acceleration (plenary talk by A. MacKinnon), which historically has grown out of inertial fusion research, and HIF Accelerator Research (invited talk by A. Friedman), which will require impressive advancements in space-charge-limited ion beam physics and in understanding the generation and transport of neutralized ion beams. A unifying aspect of High Energy Density applications was the physics of particle beams inside of solids, which is proving to

Accelerated Electron-Beam Formation with a High Capture Coefficient in a Parallel Coupled Accelerating Structure

Science.gov (United States)

Chernousov, Yu. D.; Shebolaev, I. V.; Ikryanov, I. M.

2018-01-01

An electron beam with a high (close to 100%) coefficient of electron capture into the regime of acceleration has been obtained in a linear electron accelerator based on a parallel coupled slow-wave structure, electron gun with microwave-controlled injection current, and permanent-magnet beam-focusing system. The high capture coefficient was due to the properties of the accelerating structure, beam-focusing system, and electron-injection system. Main characteristics of the proposed systems are presented.

High-Field Accelerator Magnets

International Nuclear Information System (INIS)

Rijk, G de

2014-01-01

In this lecture an overview is given of the present technology for high field accelerator magnets. We indicate how to get high fields and what are the most important parameters. The available conductors and their limitations are presented followed by the most relevant types of coils and support structures. We conclude by showing a number of recent examples of development magnets which are either pure R&D objects or models for the LHC luminosity upgrade

Voltage generators of high voltage high power accelerators

International Nuclear Information System (INIS)

Svinin, M.P.

1981-01-01

High voltage electron accelerators are widely used in modern radiation installations for industrial purposes. In the near future further increasing of their power may be effected, which enables to raise the efficiency of the radiation processes known and to master new power-consuming production in industry. Improvement of HV generators by increasing their power and efficiency is one of many scientific and engineering aspects the successful solution of which provides further development of these accelerators and their technical parameters. The subject is discussed in detail. (author)

Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.

Science.gov (United States)

Daltro, Pâmela Santana; Alves, Paula Santana; Castro, Murilo Fagundes; Azevedo, Carine M; Vasconcelos, Juliana Fraga; Allahdadi, Kyan James; de Freitas, Luiz Antônio Rodrigues; de Freitas Souza, Bruno Solano; Dos Santos, Ricardo Ribeiro; Soares, Milena Botelho Pereira; Macambira, Simone Garcia

2015-12-03

High fat diet (HFD) is a major contributor to the development of obesity and cardiovascular diseases due to the induction of cardiac structural and hemodynamic abnormalities. We used a model of diabetic cardiomyopathy in C57Bl/6 mice fed with a HFD to investigate the effects of granulocyte-colony stimulating factor (G-CSF), a cytokine known for its beneficial effects in the heart, on cardiac anatomical and functional abnormalities associated with obesity and type 2 diabetes. Groups of C57Bl/6 mice were fed with standard diet (n = 8) or HFD (n = 16). After 36 weeks, HFD animals were divided into a group treated with G-CSF + standard diet (n = 8) and a vehicle control group + standard diet (n = 8). Cardiac structure and function were assessed by electrocardiography, echocardiography and treadmill tests, in addition to the evaluation of body weight, fasting glicemia, insulin and glucose tolerance at different time points. Histological analyses were performed in the heart tissue. HFD consumption induced metabolic alterations characteristic of type 2 diabetes and obesity, as well as cardiac fibrosis and reduced exercise capacity. Upon returning to a standard diet, obese mice body weight returned to non-obese levels. G-CSF administration accelerated the reduction in of body weight in obese mice. Additionally, G-CSF treatment reduced insulin levels, diminished heart fibrosis, increased exercise capacity and reversed cardiac alterations, including bradycardia, elevated QRS amplitude, augmented P amplitude, increased septal wall thickness, left ventricular posterior thickening and cardiac output reduction. Our results indicate that G-CSF administration caused beneficial effects on obesity-associated cardiac impairment.

Nested high voltage generator/particle accelerator

International Nuclear Information System (INIS)

Adler, R.J.

1992-01-01

This patent describes a modular high voltage particle accelerator having an emission axis and an emission end, the accelerator. It comprises: a plurality of high voltage generators in nested adjacency to form a nested stack, each the generator comprising a cup-like housing having a base and a tubular sleeve extending from the base, a primary transformer winding encircling the nested stack; a secondary transformer winding between each adjacent pair of housings, magnetically linked to the primary transformer winding through the gaps; a power supply respective to each of the secondary windings converting alternating voltage from its respective secondary winding to d.c. voltage, the housings at the emission end forming a hollow throat for particle acceleration, a vacuum seal at the emission end of the throat which enables the throat to be evacuated; a particle source in the thrond power means to energize the primary transformer winding

Dose-modeling study to compare external beam techniques from protocol NSABP B-39/RTOG 0413 for patients with highly unfavorable cardiac anatomy

International Nuclear Information System (INIS)

Hiatt, Jessica R.; Evans, Suzanne B.; Price, Lori Lyn; Cardarelli, Gene A.; Di Petrillo, Thomas A.; Wazer, David E.

2006-01-01

Purpose: The aim of this study was to select patients with heart anatomy that is specifically unfavorable for tangential irradiation in whole-breast radiotherapy (WBRT), to be used as an experimental cohort to compare cardiac dosimetric and radiobiological parameters of three-dimensional conformal external beam accelerated partial breast irradiation (3D-CRT APBI) to WBRT with techniques as defined by the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-39/Radiation Therapy Oncology Group (RTOG) 0413 clinical trial. Methods and Materials: A dosimetric modeling study that compared WBRT and 3D-CRT APBI was performed on CT planning data from 8 patients with left-sided breast cancer. Highly unfavorable cardiac anatomy was defined by the measured contact of the myocardium with the anterior chest wall in the axial and para-sagittal planes. Treatment plans of WBRT and 3D-CRT APBI were generated for each patient in accordance with NSABP B-39/RTOG 0413 protocol. Dose-volume relationships of the heart, including the V 5 min (minimum dose delivered to 5% of the cardiac volume), biological effective dose (BED) of the V 5 min, and normal tissue complication probability (NTCP) were analyzed and compared. Results: Despite expected anatomic variation, significantly large differences were found favoring 3D-CRT APBI in cumulative dose-volume histograms (p 5 min (mean difference, 24.53 Gy; p 5 min (85%, p < 0.01). Conclusions: Use of 3D-CRT APBI can demonstrate improved sparing of the heart in select patients with highly unfavorable cardiac anatomy for WBRT, and may result in reduced risk of cardiac morbidity and mortality

Time to shift from contemporary to high-sensitivity cardiac troponin in diagnosis of acute coronary syndromes

Directory of Open Access Journals (Sweden)

Jamshed J. Dalal

2016-11-01

Training and displaying the clinical algorithm depicting the role of hs-TnI assay in acute cardiac care units and in EDs are an efficient way to deliver the new standard of care to patients. Compared with contemporary troponin assays, the hs-cTn assay accelerates the diagnostic pathway to 0–1 h, thus reducing the time for diagnosis of NSTEMI and hence, its management.

Radiation safety aspects of high energy particle accelerators

International Nuclear Information System (INIS)

Subbaiah, K.V.

2007-01-01

High-energy accelerators are widely used for various applications in industry, medicine and research. These accelerators are capable of accelerating both ions and electrons over a wide range of energy and subsequently are made to impinge on the target materials. Apart from generating intended reactions in the target, these projectiles can also generate highly penetrating radiations such as gamma rays and neutrons. Over exposure to these radiations will cause deleterious effects on the living beings. Various steps taken to protect workers and general public from these harmful radiations is called radiation safety. The primary objective in establishing permissible values for occupational workers is to keep the radiation worker well below a level at which adverse effects are likely to be observed during one's life time. Another objective is to minimize the incidence of genetic effects for the population as a whole. Today's presentation on radiation safety of accelerators will touch up on the following sub-topics: Types of particle accelerators and their applications; AERB directives on dose limits; Radiation Source term of accelerators; Shielding Design-Use of Transmission curves and Tenth Value layers; Challenges for accelerator health physicists

Radiation protection of the operation of accelerator facilities. On high energy proton and electron accelerators

International Nuclear Information System (INIS)

Kondo, Kenjiro

1997-01-01

Problems in the radiation protection raised by accelerated particles with energy higher than several hundreds MeV in strong accelerator facilities were discussed in comparison with those with lower energy in middle- and small-scale facilities. The characteristics in the protection in such strong accelerator facilities are derived from the qualitative changes in the interaction between the high energy particles and materials and from quantitative one due to the beam strength. In the former which is dependent on the emitting mechanism of the radiation, neutron with broad energy spectrum and muon are important in the protection, and in the latter, levels of radiation and radioactivity which are proportional to the beam strength are important. The author described details of the interaction between high energy particles and materials: leading to the conclusion that in the electron accelerator facilities, shielding against high energy-blemsstrahlung radiation and -neutron is important and in the proton acceleration, shielding against neutron is important. The characteristics of the radiation field in the strong accelerator facilities: among neutron, ionized particles and electromagnetic wave, neutron is most important in shielding since it has small cross sections relative to other two. Considerations for neutron are necessary in the management of exposure. Multiplicity of radionuclides produced: which is a result of nuclear spallation reaction due to high energy particles, especially to proton. Radioactivation of the accelerator equipment is a serious problem. Other problems: the interlock systems, radiation protection for experimenters and maintenance of the equipment by remote systems. (K.H.). 11 refs

High-current beam transport in electrostatic accelerator tubes

International Nuclear Information System (INIS)

Ramian, G.; Elais, L.

1987-01-01

The UCSB Free Electron Laser (FEL) has successfully demonstrated the use of a commercial 6 megavolt electrostatic accelerator as a high current beam source in a recirculating configuration. The accelerator, manufactured by National Electrostatics Corp. (NEC), Middleton WI, uses two standard high gradient accelerator tubes. Suppression of ion multiplication was accomplished by NEC with apertures and a shaped electrostatic field. This field shaping has fortuitously provided a periodically reversing radial field component with sufficient focusing strength to transport electron beams of up to 3 Amps current. Present two-stage FEL work requires a 20 Amp beam and proposed very high voltage FEL designs require currents as high as 100 Amps. A plan to permit transport of such high current beams by the addition of solenoidal focussing elements is described

High-sensitivity mass spectrometry with a tandem accelerator

International Nuclear Information System (INIS)

Henning, W.

1984-01-01

The characteristic features of accelerator mass spectrometry are discussed. A short overview is given of the current status of mass spectrometry with high-energy (MeV/nucleon) heavy-ion accelerators. Emphasis is placed on studies with tandem accelerators and on future mass spectrometry of heavier isotopes with the new generation of higher-voltage tandems

The joint project for high-intensity proton accelerators

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-08-01

Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK) agreed to promote the joint project integrating both the Neutron Science Project (NSP) of JAERI and the Japan Hadron Facility Project (JHF) of KEK for comprehensive studies on basic science and technology using high-intensity proton accelerator. This document describes the joint proposal prepared by the Joint Project Team of JAERI and KEK to construct accelerators and research facilities necessary both for the NSP and the JHF at the site of JAERI Tokai Establishment. (author)

Future Accelerator Challenges in Support of High-Energy Physics

International Nuclear Information System (INIS)

Zisman, Michael S.; Zisman, M.S.

2008-01-01

Historically, progress in high-energy physics has largely been determined by development of more capable particle accelerators. This trend continues today with the imminent commissioning of the Large Hadron Collider at CERN, and the worldwide development effort toward the International Linear Collider. Looking ahead, there are two scientific areas ripe for further exploration--the energy frontier and the precision frontier. To explore the energy frontier, two approaches toward multi-TeV beams are being studied, an electron-positron linear collider based on a novel two-beam powering system (CLIC), and a Muon Collider. Work on the precision frontier involves accelerators with very high intensity, including a Super-BFactory and a muon-based Neutrino Factory. Without question, one of the most promising approaches is the development of muon-beam accelerators. Such machines have very high scientific potential, and would substantially advance the state-of-the-art in accelerator design. The challenges of the new generation of accelerators, and how these can be accommodated in the accelerator design, are described. To reap their scientific benefits, all of these frontier accelerators will require sophisticated instrumentation to characterize the beam and control it with unprecedented precision

Future Accelerator Challenges in Support of High-Energy Physics

Energy Technology Data Exchange (ETDEWEB)

Zisman, Michael S.; Zisman, M.S.

2008-05-03

Historically, progress in high-energy physics has largely been determined by development of more capable particle accelerators. This trend continues today with the imminent commissioning of the Large Hadron Collider at CERN, and the worldwide development effort toward the International Linear Collider. Looking ahead, there are two scientific areas ripe for further exploration--the energy frontier and the precision frontier. To explore the energy frontier, two approaches toward multi-TeV beams are being studied, an electron-positron linear collider based on a novel two-beam powering system (CLIC), and a Muon Collider. Work on the precision frontier involves accelerators with very high intensity, including a Super-BFactory and a muon-based Neutrino Factory. Without question, one of the most promising approaches is the development of muon-beam accelerators. Such machines have very high scientific potential, and would substantially advance the state-of-the-art in accelerator design. The challenges of the new generation of accelerators, and how these can be accommodated in the accelerator design, are described. To reap their scientific benefits, all of these frontier accelerators will require sophisticated instrumentation to characterize the beam and control it with unprecedented precision.

Ultra-High Intensity Proton Accelerators and their Applications

International Nuclear Information System (INIS)

Weng, W. T.

1997-01-01

The science and technology of proton accelerators have progressed considerably in the past three decades. Three to four orders of magnitude increase in both peak intensity and average flux have made it possible to construct high intensity proton accelerators for modern applications, such as: spallation neutron sources, kaon factory, accelerator production of tritium, energy amplifier and muon collider drivers. The accelerator design focus switched over from intensity for synchrotrons, to brightness for colliders to halos for spallation sources. An overview of this tremendous progress in both accelerator science and technology is presented, with special emphasis on the new challenges of accelerator physics issues such as: H(-) injection, halo formation and reduction of losses

Predicting response to cardiac resynchronization therapy with cross-correlation analysis of myocardial systolic acceleration: a new approach to echocardiographic dyssynchrony evaluation

DEFF Research Database (Denmark)

Olsen, Niels Thue; Mogelvang, Rasmus; Jons, Christian

2009-01-01

BACKGROUND: We tested the ability of cross-correlation analysis of myocardial systolic acceleration (XCA), a new marker of dyssynchrony based on tissue Doppler echocardiography, to predict long-term outcome of cardiac resynchronization therapy (CRT) and to discriminate between control patients...... and patients with dyssynchrony. METHODS: XCA was performed by off-line analysis of digitally stored myocardial velocity curves in 44 patients treated with CRT and followed for 13 +/- 2 months. We tested the ability of preimplant XCA to identify long-term responders to CRT (defined by a decrease in left...

High temperature superconductor accelerator magnets

NARCIS (Netherlands)

van Nugteren, J.

2016-01-01

For future particle accelerators bending dipoles are considered with magnetic fields exceeding 20T. This can only be achieved using high temperature superconductors (HTS). These exhibit different properties from classical low temperature superconductors and still require significant research and

The heart rate increase at the onset of high-work intensity exercise is accelerated by central blood volume loading.

Science.gov (United States)

Miyamoto, Tadayoshi; Oshima, Yoshitake; Ikuta, Komei; Kinoshita, Hiroshi

2006-01-01

Using a water immersion (WI) method, the combined effect of central blood volume (CBV) loading and work intensity on the time course of heart rate (HR) at the onset of upright dynamic exercise was investigated. Seven males cranked a cycle ergometer for 12 min using their un-immersed arms at low-, moderate- and high-work intensities, followed by a 12-min rest. For WI, the pre-exercise resting cardiac output increased by 36%, while HR decreased by 22% [from 76.8 (10.4) to 59.6 (9.8) beats/min]. WI also increased the high-frequency (HF, 0.15-0.40 Hz) component of the HR variability, suggesting an increased vagal activity. During the initial 2 min of the exercise period at low-work intensity, HR increased by 34.9 and 25.8% in the WI and control conditions, respectively. These were 117 and 73% at high-work intensity, indicating more accelerated HR with WI than the control. The plasma norepinephrine concentration increased less during high-work intensity exercise during WI, as compared to exercise during control conditions. In conclusion, the HR increase at the onset of high-work intensity exercise is accelerated by CBV loading but not at low intensity, possibly reflecting vago-sympathetic interaction and reduced baroreflex sensitivity.

Relativistic klystron research for high gradient accelerators

International Nuclear Information System (INIS)

Allen, M.A.; Callin, R.S.; Deruyter, H.

1988-06-01

Relativistic klystrons are being developed as a power source for high gradient accelerator applications which include large linear electron--positron colliders, compact accelerators, and FEL sources. We have attained 200MW peak power at 11.4 GHz from a relativistic klystron, and 140 MV/m longitudinal gradient in a short 11.4 GHz accelerator section. We report here on the design of our first klystrons, the results of our experiments so far, and some of our plans for the near future. 5 refs., 7 figs

High current electron beam acceleration in dielectric-filled RF cavities

International Nuclear Information System (INIS)

Faehl, R.J.; Keinigs, R.K.

1996-01-01

The acceleration of charged particles in radio frequency (RF) cavities is a widely used mode in high energy accelerators. Advantages include very high accelerating gradients and very stable phase control. A traditional limitation for such acceleration has been their use for intense, high current beam generation. This constraint arises from the inability to store a large amount of electromagnetic energy in the cavity and from loading effects of the beam on the cavity. The authors have studied a simple modification to transcend these limitations. Following Humphries and Huang, they have conducted analytic and numerical investigations of RF accelerator cavities in which a high dielectric constant material, such as water, replaces most of the cavity volume. This raises the stored energy in a cavity of given dimensions by a factor var-epsilon/var-epsilon 0 . For a water fill, var-epsilon/var-epsilon 0 ∼ 80, depending on the frequency. This introduction of high dielectric constant material into the cavity reduces the resonant frequencies by a factor of (var-epsilon/var-epsilon 0 ) 1/2 . This reduced operating frequency mans that existing high efficiency power supplies, at lower frequencies, can be used for an accelerator

Experimental Studies of W-Band Accelerator Structures at High Field

Energy Technology Data Exchange (ETDEWEB)

Hill, Marc E

2001-02-09

A high-gradient electron accelerator is desired for high-energy physics research, where frequency scalings of breakdown and trapping of itinerant beamline particles dictates operation of the accelerator at short wavelengths. The first results of design and test of a high-gradient mm-wave linac with an operating frequency at 91.392 GHz (W-band) are presented. A novel approach to particle acceleration is presented employing a planar, dielectric lined waveguide used for particle acceleration. The traveling wave fields in the planar dielectric accelerator (PDA) are analyzed for an idealized structure, along with a circuit equivalent model used for understanding the structure as a microwave circuit. Along with the W-band accelerator structures, other components designed and tested are high power rf windows, high power attenuators, and a high power squeeze-type phase shifter. The design of the accelerator and its components where eased with the aide of numerical simulations using a finite-difference electromagnetic field solver. Manufacturing considerations of the small, delicate mm-wave components and the steps taken to reach a robust fabrication process are detailed. These devices were characterized under low power using a two-port vector network analyzer to verify tune and match, including measurements of the structures' fields using a bead-pull. The measurements are compared with theory throughout. Addition studies of the W-band structures were performed under high power utilizing a 11.424 GHz electron linac as a current source. Test results include W-band power levels of 200 kW, corresponding to fields in the PDA of over 20 MV/m, a higher gradient than any collider. Planar accelerator devices naturally have an rf quadrupole component of the accelerating field. Presented for the first time are the measurements of this effect.

Application of Plasma Waveguides to High Energy Accelerators

Energy Technology Data Exchange (ETDEWEB)

Milchberg, Howard M

2013-03-30

The eventual success of laser-plasma based acceleration schemes for high-energy particle physics will require the focusing and stable guiding of short intense laser pulses in reproducible plasma channels. For this goal to be realized, many scientific issues need to be addressed. These issues include an understanding of the basic physics of, and an exploration of various schemes for, plasma channel formation. In addition, the coupling of intense laser pulses to these channels and the stable propagation of pulses in the channels require study. Finally, new theoretical and computational tools need to be developed to aid in the design and analysis of experiments and future accelerators. Here we propose a 3-year renewal of our combined theoretical and experimental program on the applications of plasma waveguides to high-energy accelerators. During the past grant period we have made a number of significant advances in the science of laser-plasma based acceleration. We pioneered the development of clustered gases as a new highly efficient medium for plasma channel formation. Our contributions here include theoretical and experimental studies of the physics of cluster ionization, heating, explosion, and channel formation. We have demonstrated for the first time the generation of and guiding in a corrugated plasma waveguide. The fine structure demonstrated in these guides is only possible with cluster jet heating by lasers. The corrugated guide is a slow wave structure operable at arbitrarily high laser intensities, allowing direct laser acceleration, a process we have explored in detail with simulations. The development of these guides opens the possibility of direct laser acceleration, a true miniature analogue of the SLAC RF-based accelerator. Our theoretical studies during this period have also contributed to the further development of the simulation codes, Wake and QuickPIC, which can be used for both laser driven and beam driven plasma based acceleration schemes. We

Computer applications: Automatic control system for high-voltage accelerator

International Nuclear Information System (INIS)

Bryukhanov, A.N.; Komissarov, P.Yu.; Lapin, V.V.; Latushkin, S.T.. Fomenko, D.E.; Yudin, L.I.

1992-01-01

An automatic control system for a high-voltage electrostatic accelerator with an accelerating potential of up to 500 kV is described. The electronic apparatus on the high-voltage platform is controlled and monitored by means of a fiber-optic data-exchange system. The system is based on CAMAC modules that are controlled by a microprocessor crate controller. Data on accelerator operation are represented and control instructions are issued by means of an alphanumeric terminal. 8 refs., 6 figs

Towards a five-minute comprehensive cardiac MR examination using highly accelerated parallel imaging with a 32-element coil array: feasibility and initial comparative evaluation.

Science.gov (United States)

Xu, Jian; Kim, Daniel; Otazo, Ricardo; Srichai, Monvadi B; Lim, Ruth P; Axel, Leon; Mcgorty, Kelly Anne; Niendorf, Thoralf; Sodickson, Daniel K

2013-07-01

To evaluate the feasibility and perform initial comparative evaluations of a 5-minute comprehensive whole-heart magnetic resonance imaging (MRI) protocol with four image acquisition types: perfusion (PERF), function (CINE), coronary artery imaging (CAI), and late gadolinium enhancement (LGE). This study protocol was Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board-approved. A 5-minute comprehensive whole-heart MRI examination protocol (Accelerated) using 6-8-fold-accelerated volumetric parallel imaging was incorporated into and compared with a standard 2D clinical routine protocol (Standard). Following informed consent, 20 patients were imaged with both protocols. Datasets were reviewed for image quality using a 5-point Likert scale (0 = non-diagnostic, 4 = excellent) in blinded fashion by two readers. Good image quality with full whole-heart coverage was achieved using the accelerated protocol, particularly for CAI, although significant degradations in quality, as compared with traditional lengthy examinations, were observed for the other image types. Mean total scan time was significantly lower for the Accelerated as compared to Standard protocols (28.99 ± 4.59 min vs. 1.82 ± 0.05 min, P simplified scan prescription and high spatial and temporal resolution enabled by highly parallel imaging technology. The study also highlights technical hurdles that remain to be addressed. Although image quality remained diagnostic for most scan types, the reduced image quality of PERF, CINE, and LGE scans in the Accelerated protocol remain a concern. Copyright © 2012 Wiley Periodicals, Inc.

CERN/KEK: Very high accelerating gradients

Energy Technology Data Exchange (ETDEWEB)

Anon.

1993-01-15

Full text: A world-wide effort is under way to develop linear electron-positron colliders so that physics experiments can be extended into a range of energies where circular machines (necessarily much larger than CERN's 27-kilometre LEP machine) would be crippled by synchrotron radiation. CERN is studying the feasibility of building a 2 TeV machine called CLIC powered not by individual klystrons, but by a high intensity electron 'drive' linac running parallel to the main linac (November 1990, page 7). This drive linac will itself be powered by similar superconducting cavities to those developed for LEP. A high gradient is an obvious design aim for any future high energy linear collider because it makes it shorter and therefore cheaper - the design figure for the CLIC machine is 80 MV/m. The CLIC study group has taken a significant step forward in demonstrating the technical feasibility of their machine by achieving peak and average accelerating gradients of 137 MV/m and 84 MV/m respectively in a short section of accelerating structure during high gradient tests at the Japanese KEK Laboratory last year. This result obtained within the framework of a CERN/KEK collaboration on linear colliders was obtained using a 20-cell accelerating section built at CERN using state-of the- art technology which served both as a model for CLIC studies as well as a prototype for the Japanese Linear Collider studies. The operating frequency of the model accelerating section is 2.6 times lower than the CLIC frequency but was chosen because a high power r.f. source and pulse compression scheme has been developed for this frequency at KEK. Testing CLIC models at 11.4 GHz is however more stringent than at 30 GHz because the chance of electrical breakdown increases as the frequency is lowered. This recent result clearly demonstrates that a gradient of 80 MV/m is feasible.

CERN/KEK: Very high accelerating gradients

International Nuclear Information System (INIS)

Anon.

1993-01-01

Full text: A world-wide effort is under way to develop linear electron-positron colliders so that physics experiments can be extended into a range of energies where circular machines (necessarily much larger than CERN's 27-kilometre LEP machine) would be crippled by synchrotron radiation. CERN is studying the feasibility of building a 2 TeV machine called CLIC powered not by individual klystrons, but by a high intensity electron 'drive' linac running parallel to the main linac (November 1990, page 7). This drive linac will itself be powered by similar superconducting cavities to those developed for LEP. A high gradient is an obvious design aim for any future high energy linear collider because it makes it shorter and therefore cheaper - the design figure for the CLIC machine is 80 MV/m. The CLIC study group has taken a significant step forward in demonstrating the technical feasibility of their machine by achieving peak and average accelerating gradients of 137 MV/m and 84 MV/m respectively in a short section of accelerating structure during high gradient tests at the Japanese KEK Laboratory last year. This result obtained within the framework of a CERN/KEK collaboration on linear colliders was obtained using a 20-cell accelerating section built at CERN using state-of the- art technology which served both as a model for CLIC studies as well as a prototype for the Japanese Linear Collider studies. The operating frequency of the model accelerating section is 2.6 times lower than the CLIC frequency but was chosen because a high power r.f. source and pulse compression scheme has been developed for this frequency at KEK. Testing CLIC models at 11.4 GHz is however more stringent than at 30 GHz because the chance of electrical breakdown increases as the frequency is lowered. This recent result clearly demonstrates that a gradient of 80 MV/m is feasible

High Density Sphere Culture of Adult Cardiac Cells Increases the Levels of Cardiac and Progenitor Markers and Shows Signs of Vasculogenesis

Directory of Open Access Journals (Sweden)

Kristina Vukusic

2013-01-01

Full Text Available 3D environment and high cell density play an important role in restoring and supporting the phenotypes of cells represented in cardiac tissues. The aim of this study was therefore to investigate the suitability of high density sphere (HDS cultures for studies of cardiomyocyte-, endothelial-, and stem-cell biology. Primary adult cardiac cells from nine human biopsies were cultured using different media for up to 9 weeks. The possibilities to favor a certain cell phenotype and induce production of extra cellular matrix (ECM were studied by histology, immunohistochemistry, and quantitative real-time PCR. Defined media gave significant increase in both cardiac- and progenitor-specific markers and also an intraluminal position of endothelial cells over time. Cardiac media showed indication of differentiation and maturity of HDS considering the ECM production and activities within NOTCH regulation but no additional cardiac differentiation. Endothelial media gave no positive effects on endothelial phenotype but increased proliferation without fibroblast overgrowth. In addition, indications for early vasculogenesis were found. It was also possible to affect the Wnt signaling in HDS by addition of a glycogen synthase kinase 3 (GSK3 inhibitor. In conclusion, these findings show the suitability of HDS as in vitro model for studies of cardiomyocyte-, endothelial-, and stem-cell biology.

Assessment of left ventricular function with single breath-hold highly accelerated cine MRI combined with guide-point modeling

International Nuclear Information System (INIS)

Heilmaier, Christina; Nassenstein, Kai; Nielles-Vallespin, Sonia; Zuehlsdorff, Sven; Hunold, Peter; Barkhausen, Joerg

2010-01-01

Purpose: To prospectively assess the performance of highly accelerated cine MRI in multi-orientations combined with a new guide-point modeling post-processing technique (GPM approach) for assessment of left ventricular (LV) function compared to the standard summation of slices method based on a stack of short axis views (SoS approach). Materials and methods: 33 consecutive patients were examined on a 1.5 T scanner with a standard steady state free precession (SSFP) sequence (TR, 3.0 ms; TE, 1.5 m; flip angle (FA), 60 o ; acceleration factor (AF), 2) analyzed with the SoS method and a highly accelerated, single breath-hold temporal parallel acquisition SSFP sequence (TR, 4.6 ms; TE, 1.1 ms; AF, 3) post-processed with the GPM method. LV function values were measured by two independent readers with different experience in cardiac MRI and compared by using the paired t-test and F-test. Inter- and intraobserver agreements were calculated using Bland-Altman-Plots. Results: Mean acquisition and post-processing time was significantly shorter with the GPM approach (15 s/3 min versus 360 s/6 min). For all LV function parameters interobserver agreement between the experienced and non-experienced reader was significantly improved when the GPM approach was used. However, end-diastolic and end-systolic volumes were larger for the GPM technique when compared to the SoS method (P 0.121). In both readers and for all parameters variances did not differ significantly (P ≥ 0.409) and the two approaches showed an excellent linear correlation (r > 0.951). Conclusion: Due to its accurate, fast and reproducible assessment of LV function parameters highly accelerated MRI combined with the GPM technique may become the technique of first choice for assessment of LV function in clinical routine.

R and D status of high-current accelerators at IFP

International Nuclear Information System (INIS)

Deng, J. J.; Shi, J. S.; Xie, W. P.

2011-01-01

High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Z-pinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 x 60 ns) to be built will be presented briefly.

Drift tube suspension for high intensity linear accelerators

International Nuclear Information System (INIS)

Clark, D.C.; Frank, J.A.; Liska, D.J.; Potter, R.C.; Schamaun, R.G.

1982-01-01

The disclosure relates to a drift tube suspension for high intensity linear accelerators. The system comprises a series of box-sections girders independently adjustably mounted on a linear accelerator. A plurality of drift tube holding stems are individually adjustably mounted on each girder

Drift tube suspension for high intensity linear accelerators

Science.gov (United States)

Liska, Donald J.; Schamaun, Roger G.; Clark, Donald C.; Potter, R. Christopher; Frank, Joseph A.

1982-01-01

The disclosure relates to a drift tube suspension for high intensity linear accelerators. The system comprises a series of box-sections girders independently adjustably mounted on a linear accelerator. A plurality of drift tube holding stems are individually adjustably mounted on each girder.

Parametric study of emerging high power accelerator applications using Accelerator Systems Model (ASM)

International Nuclear Information System (INIS)

Berwald, D.H.; Mendelsohn, S.S.; Myers, T.J.; Paulson, C.C.; Peacock, M.A.; Piaszczyk, CM.; Rathke, J.W.; Piechowiak, E.M.

1996-01-01

Emerging applications for high power rf linacs include fusion materials testing, generation of intense spallation neutrons for neutron physics and materials studies, production of nuclear materials and destruction of nuclear waste. Each requires the selection of an optimal configuration and operating parameters for its accelerator, rf power system and other supporting subsystems. Because of the high cost associated with these facilities, economic considerations become paramount, dictating a full evaluation of the electrical and rf performance, system reliability/availability, and capital, operating, and life cycle costs. The Accelerator Systems Model (ASM), expanded and modified by Northrop Grumman during 1993-96, provides a unique capability for detailed layout and evaluation of a wide variety of normal and superconducting accelerator and rf power configurations. This paper will discuss the current capabilities of ASM, including the available models and data base, and types of trade studies that can be performed for the above applications. (author)

Accelerated two-dimensional cine DENSE cardiovascular magnetic resonance using compressed sensing and parallel imaging.

Science.gov (United States)

Chen, Xiao; Yang, Yang; Cai, Xiaoying; Auger, Daniel A; Meyer, Craig H; Salerno, Michael; Epstein, Frederick H

2016-06-14

Cine Displacement Encoding with Stimulated Echoes (DENSE) provides accurate quantitative imaging of cardiac mechanics with rapid displacement and strain analysis; however, image acquisition times are relatively long. Compressed sensing (CS) with parallel imaging (PI) can generally provide high-quality images recovered from data sampled below the Nyquist rate. The purposes of the present study were to develop CS-PI-accelerated acquisition and reconstruction methods for cine DENSE, to assess their accuracy for cardiac imaging using retrospective undersampling, and to demonstrate their feasibility for prospectively-accelerated 2D cine DENSE imaging in a single breathhold. An accelerated cine DENSE sequence with variable-density spiral k-space sampling and golden angle rotations through time was implemented. A CS method, Block LOw-rank Sparsity with Motion-guidance (BLOSM), was combined with sensitivity encoding (SENSE) for the reconstruction of under-sampled multi-coil spiral data. Seven healthy volunteers and 7 patients underwent 2D cine DENSE imaging with fully-sampled acquisitions (14-26 heartbeats in duration) and with prospectively rate-2 and rate-4 accelerated acquisitions (14 and 8 heartbeats in duration). Retrospectively- and prospectively-accelerated data were reconstructed using BLOSM-SENSE and SENSE. Image quality of retrospectively-undersampled data was quantified using the relative root mean square error (rRMSE). Myocardial displacement and circumferential strain were computed for functional assessment, and linear correlation and Bland-Altman analyses were used to compare accelerated acquisitions to fully-sampled reference datasets. For retrospectively-undersampled data, BLOSM-SENSE provided similar or lower rRMSE at rate-2 and lower rRMSE at rate-4 acceleration compared to SENSE (p cine DENSE provided good image quality and expected values of displacement and strain. BLOSM-SENSE-accelerated spiral cine DENSE imaging with 2D displacement encoding can be

JAERI-KEK joint project on high intensity proton accelerators

International Nuclear Information System (INIS)

Nagamiya, Shoji

2000-01-01

Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Organization (KEK) are promoting the joint project integrating both the Neutron Science Project (NSP) of JAERI and the Japan Hadron Facility Project (JHF) of KEK for comprehensive studies on basic science and technology using high-intensity proton accelerator. This paper describes the joint project prepared by the Joint Project Team of JAERI and KEK to construct accelerators and research facilities necessary both for the NSP and the JHF at the site of JAERI Tokai Establishment. (author)

High Accelerating Field Superconducting Radio Frequency Cavities

Science.gov (United States)

Orr, R. S.; Saito, K.; Furuta, F.; Saeki, T.; Inoue, H.; Morozumi, Y.; Higo, T.; Higashi, Y.; Matsumoto, H.; Kazakov, S.; Yamaoka, H.; Ueno, K.; Sato, M.

2008-06-01

We have conducted a study of a series of single cell superconducting RF cavities at KEK. These tests were designed to investigate the effect of surface treatment on the maximum accelerating field attainable. All of these cavities are of the ICHIRO shape, based on the Low Loss shape. Our results indicate that accelerating fields as high as the theoretical maximum of 50MV/m are attainable.

High efficiency beam splitting for H- accelerators

International Nuclear Information System (INIS)

Kramer, S.L.; Stipp, V.; Krieger, C.; Madsen, J.

1985-01-01

Beam splitting for high energy accelerators has typically involved a significant loss of beam and radiation. This paper reports on a new method of splitting beams for H - accelerators. This technique uses a high intensity flash of light to strip a fraction of the H - beam to H 0 which are then easily separated by a small bending magnet. A system using a 900-watt (average electrical power) flashlamp and a highly efficient collector will provide 10 -3 to 10 -2 splitting of a 50 MeV H - beam. Results on the operation and comparisons with stripping cross sections are presented. Also discussed is the possibility for developing this system to yield a higher stripping fraction

High-field dipoles for future accelerators

International Nuclear Information System (INIS)

Wipf, S.L.

1984-09-01

This report presents the concept for building superconducting accelerator dipoles with record high fields. Economic considerations favor the highest possible current density in the windings. Further discussion indicates that there is an optimal range of pinning strength for a superconducting material and that it is not likely for multifilamentary conductors to ever equal the potential performance of tape conductors. A dipole design with a tape-wound, inner high-field winding is suggested. Methods are detailed to avoid degradation caused by flux jumps and to overcome problems with the dipole ends. Concerns for force support structure and field precision are also addressed. An R and D program leading to a prototype 11-T dipole is outlined. Past and future importance of superconductivity to high-energy physics is evident from a short historical survey. Successful dipoles in the 10- to 20-T range will allow interesting options for upgrading present largest accelerators

CAS Accelerator Physics (High-Power Hadron Machines) in Spain

CERN Multimedia

CAS

2011-01-01

The CERN Accelerator School (CAS) and ESS-Bilbao jointly organised a specialised course on High-Power Hadron Machines, held at the Hotel Barceló Nervión in Bilbao, Spain, from 24 May to 2 June, 2011.   CERN Accelerator School students. After recapitulation lectures on the essentials of accelerator physics and review lectures on the different types of accelerators, the programme focussed on the challenges of designing and operating high-power facilities. The particular problems for RF systems, beam instrumentation, vacuum, cryogenics, collimators and beam dumps were examined. Activation of equipment, radioprotection and remote handling issues were also addressed. The school was very successful, with 69 participants of 22 nationalities. Feedback from the participants was extremely positive, praising the expertise and enthusiasm of the lecturers, as well as the high standard and excellent quality of their lectures. In addition to the academic programme, the participants w...

Development of High-Gradient Dielectric Laser-Driven Particle Accelerator Structures

Energy Technology Data Exchange (ETDEWEB)

Byer, Robert L. [Stanford Univ., CA (United States). Edward L. Ginzton Lab.

2013-11-07

The thrust of Stanford's program is to conduct research on high-gradient dielectric accelerator structures driven with high repetition-rate, tabletop infrared lasers. The close collaboration between Stanford and SLAC (Stanford Linear Accelerator Center) is critical to the success of this project, because it provides a unique environment where prototype dielectric accelerator structures can be rapidly fabricated and tested with a relativistic electron beam.

Shielding for high energy, high intensity electron accelerator installation

International Nuclear Information System (INIS)

Warawas, C.; Chongkum, S.

1997-03-01

The utilization of electron accelerators (eBA) is gradually increased in Thailand. For instance, a 30-40 MeV eBA are used for tumor and cancer therapy in the hospitals, and a high current eBA in for gemstone colonization. In the near future, an application of eBA in industries will be grown up in a few directions, e.g., flue gases treatment from the coal fire-power plants, plastic processing, rubber vulcanization and food preservation. It is the major roles of Office of Atomic Energy for Peace (OAEP) to promote the peaceful uses of nuclear energy and to regulate the public safety and protection of the environment. By taking into account of radiation safety aspect, high energy electrons are not only harmful to human bodies, but the radioactive nuclides can be occurred. This report presents a literature review by following the National Committee on Radiation Protection and Measurements (NCRP) report No.31. This reviews for parametric calculation and shielding design of the high energy (up to 100 MeV), high intensity electron accelerator installation

Particle acceleration through the resonance of high magnetic field and high frequency electromagnetic wave

International Nuclear Information System (INIS)

Hong, Liu; He, X.T.; Chen, S.G.; Zhang, W.Y.; He, X.T.; Hong, Liu

2004-01-01

We propose a new particle acceleration mechanism. Electrons can be accelerated to relativistic energy within a few electromagnetic wave cycles through the mechanism which is named electromagnetic and magnetic field resonance acceleration (EMRA). We find that the electron acceleration depends not only on the electromagnetic wave intensity, but also on the ratio between electron Larmor frequency and electromagnetic wave frequency. As the ratio approaches to unity, a clear resonance peak is observed, corresponding to the EMRA. Near the resonance regime, the strong magnetic fields still affect the electron acceleration dramatically. We derive an approximate analytical solution of the relativistic electron energy in adiabatic limit, which provides a full understanding of this phenomenon. In typical parameters of pulsar magnetospheres, the mechanism allows particles to increase their energies through the resonance of high magnetic field and high frequency electromagnetic wave in each electromagnetic wave period. The energy spectra of the accelerated particles exhibit the synchrotron radiation behavior. These can help to understand the remaining emission of high energy electron from radio pulsar within supernova remnant. The other potential application of our theory in fast ignition scheme of inertial confinement fusion is also discussed. (authors)

The evolution of high energy accelerators

International Nuclear Information System (INIS)

Courant, E.D.

1989-10-01

In this lecture I would like to trace how high energy particle accelerators have grown from tools used for esoteric small-scale experiments to gigantic projects being hotly debated in Congress as well as in the scientific community

Cryogenic Beam Screens for High-Energy Particle Accelerators

CERN Document Server

Baglin, V; Tavian, L; van Weelderen, R

2013-01-01

Applied superconductivity has become a key enabling technology for high-energy particle accelerators, thus making them large helium cryogenic systems operating at very low temperature. The circulation of high-intensity particle beams in these machines generates energy deposition in the first wall through different processes. For thermodynamic efficiency, it is advisable to intercept these beam-induced heat loads, which may be large in comparison with cryostat heat in-leaks, at higher temperature than that of the superconducting magnets of the accelerator, by means of beam screens located in the magnet apertures. Beam screens may also be used as part of the ultra-high vacuum system of the accelerator, by sheltering the gas molecules cryopumped on the beam pipe from impinging radiation and thus avoiding pressure runaway. Space being extremely tight in the magnet apertures, cooling of the long, slender beam screens also raises substantial problems in cryogenic heat transfer and fluid flow. We present sizing rule...

Williams Syndrome and Anesthesia for Non-cardiac Surgery: High Risk Can Be Mitigated with Appropriate Planning.

Science.gov (United States)

Brown, Morgan L; Nasr, Viviane G; Toohey, Rebecca; DiNardo, James A

2018-03-23

Patients with Williams syndrome are considered at high risk for anesthesia-related adverse events. At our institution, all William syndrome patients undergoing cardiac surgical, cardiac catheterization/interventional procedures, and cardiac imaging studies are cared for by cardiac anesthesiologists. All William syndrome patients undergoing non-cardiac surgical, interventional, or imaging studies are cared for by main operating room pediatric anesthesiologists with consultative input from a cardiac anesthesiologist. We reviewed our experience with 75 patients undergoing 202 separate anesthetics for 95 non-cardiac procedures and 107 cardiac procedures from 2012 to 2016. The mean age was 7.5 ± 7.0 years and the mean weight was 22.3 ± 17.0 kg. One hundred and eighty-seven patients had a general anesthetic (92.6%). Medications used included etomidate in 26.2%, propofol in 37.6%, isoflurane in 47.5%, and sevoflurane in 68.3%. Vasopressors and inotropes were required including calcium (22.8%), dopamine (10.4%), norepinephrine (17.3%), phenylephrine (35.1%), vasopressin (0.5%), and ephedrine (5.4%). The median length of stay after anesthesia was 2.8 days (range 0-32). No adverse events occurred in 89.6% of anesthetics. There were two cases of cardiac arrest, one of which required extracorporeal life support for resuscitation. Of the non-cardiac surgical procedures, 95.7% did not have a cardiovascular adverse event. Patients with Williams syndrome are at high risk for anesthesia, especially when undergoing cardiac procedures. The risk can be mitigated with appropriate planning and adherence to the hemodynamic goals for non-cardiac surgical procedures.

Is there a future for high energy accelerators?

International Nuclear Information System (INIS)

Tigner, M.

1993-01-01

The question of continuing viability of high energy accelerators as instruments of fundamental physics is discussed. It is seen that the next decade in elementary CM energies beyond SSC may be achievable with accelerators that can be imagined now. Beyond that there is room for doubt that accelerators will be the instrument of choice. History teaches that there is a good likelihood that the present perspective on the matter will be much different when the results from the few TeV region of elementary collision energies are in hand

Microparticles in high-voltage accelerator tubes

International Nuclear Information System (INIS)

Griffith, G.L.; Eastham, D.A.

1979-01-01

Microparticles with radii greater than 2 μm have been observed in a high voltage vacuum accelerator tube. The charge acquired by most of the particles is similar to the contact charging of a conducting sphere on a plane. (author)

Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.

Science.gov (United States)

Kuo, Anderson H; Li, Cun; Li, Jinqi; Huber, Hillary F; Nathanielsz, Peter W; Clarke, Geoffrey D

2017-02-15

Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental-fetal development indicate a need for models in precocial species for translation to human development. We developed a baboon model for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac magnetic resonance imaging to evaluate offspring heart function in early adulthood. Impaired diastolic and systolic cardiac function was observed in IUGR offspring with differences between male and female subjects, compared to their respective controls. Aspects of cardiac impairment found in the IUGR offspring were similar to those found in normal controls in a geriatric cohort. Understanding early cardiac biomarkers of IUGR using non-invasive imaging in this susceptible population, especially taking into account sexual dimorphisms, will aid recognition of the clinical presentation, development of biomarkers suitable for use in humans and management of treatment strategies. Extensive rodent studies have shown that reduced perinatal nutrition programmes chronic cardiovascular disease. To enable translation to humans, we developed baboon offspring cohorts from mothers fed ad libitum (control) or 70% of the control ad libitum diet in pregnancy and lactation, which were growth restricted at birth. We hypothesized that intrauterine growth restriction (IUGR) offspring hearts would show impaired function and a premature ageing phenotype. We studied IUGR baboons (8 male, 8 female, 5.7 years), control offspring (8 male, 8 female, 5.6 years - human equivalent approximately 25 years), and normal elderly (OLD) baboons (6 male, 6 female, mean 15.9 years). Left ventricular (LV) morphology and systolic and diastolic function were evaluated with cardiac MRI and normalized to body surface area. Two-way ANOVA by group

High-performance control system for a heavy-ion medical accelerator

Energy Technology Data Exchange (ETDEWEB)

Lancaster, H.D.; Magyary, S.B.; Sah, R.C.

1983-03-01

A high performance control system is being designed as part of a heavy ion medical accelerator. The accelerator will be a synchrotron dedicated to clinical and other biomedical uses of heavy ions, and it will deliver fully stripped ions at energies up to 800 MeV/nucleon. A key element in the design of an accelerator which will operate in a hospital environment is to provide a high performance control system. This control system will provide accelerator modeling to facilitate changes in operating mode, provide automatic beam tuning to simplify accelerator operations, and provide diagnostics to enhance reliability. The control system being designed utilizes many microcomputers operating in parallel to collect and transmit data; complex numerical computations are performed by a powerful minicomputer. In order to provide the maximum operational flexibility, the Medical Accelerator control system will be capable of dealing with pulse-to-pulse changes in beam energy and ion species.

High-performance control system for a heavy-ion medical accelerator

International Nuclear Information System (INIS)

Lancaster, H.D.; Magyary, S.B.; Sah, R.C.

1983-03-01

A high performance control system is being designed as part of a heavy ion medical accelerator. The accelerator will be a synchrotron dedicated to clinical and other biomedical uses of heavy ions, and it will deliver fully stripped ions at energies up to 800 MeV/nucleon. A key element in the design of an accelerator which will operate in a hospital environment is to provide a high performance control system. This control system will provide accelerator modeling to facilitate changes in operating mode, provide automatic beam tuning to simplify accelerator operations, and provide diagnostics to enhance reliability. The control system being designed utilizes many microcomputers operating in parallel to collect and transmit data; complex numerical computations are performed by a powerful minicomputer. In order to provide the maximum operational flexibility, the Medical Accelerator control system will be capable of dealing with pulse-to-pulse changes in beam energy and ion species

Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation.

Science.gov (United States)

Blue, Rebecca S; Blacher, Eric; Castleberry, Tarah L; Vanderploeg, James M

2015-11-01

Commercial spaceflight participants (SFPs) will introduce new medical challenges to the aerospace community, with unique medical conditions never before exposed to the space environment. This is a case report regarding the response of a subject with multiple cardiac malformations, including aortic insufficiency, pulmonary atresia, pulmonary valve replacement, ventricular septal defect (post-repair), and pulmonary artery stenosis (post-dilation), to centrifuge acceleration simulating suborbital flight. A 23-yr-old man with a history of multiple congenital cardiac malformations underwent seven centrifuge runs over 2 d. Day 1 consisted of two +G(z) runs (peak = +3.5 G(z), run 2) and two +G(x) runs (peak = +6.0 G(x), run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +G(x) and +G(z)). Data collected included blood pressure, electrocardiogram, pulse oximetry, neurovestibular exams, and post-run questionnaires regarding motion sickness, disorientation, greyout, and other symptoms. Despite the subject's significant medical history, he tolerated the acceleration profiles well and demonstrated no significant abnormal physiological responses. Potential risks to SFPs with aortic insufficiency, artificial heart valves, or valvular insufficiency include lower +G(z) tolerance, earlier symptom onset, and ineffective mitigation strategies such as anti-G straining maneuvers. There are no prior studies of prolonged accelerations approximating spaceflight in such individuals. This case demonstrates tolerance of acceleration profiles in an otherwise young and healthy individual with significant cardiac malformations, suggesting that such conditions may not necessarily preclude participation in commercial spaceflight.

Reliability studies of a high-power proton accelerator for accelerator-driven system applications for nuclear waste transmutation

Energy Technology Data Exchange (ETDEWEB)

Burgazzi, Luciano [ENEA-Centro Ricerche ' Ezio Clementel' , Advanced Physics Technology Division, Via Martiri di Monte Sole, 4, 40129 Bologna (Italy)]. E-mail: burgazzi@bologna.enea.it; Pierini, Paolo [INFN-Sezione di Milano, Laboratorio Acceleratori e Superconduttivita Applicata, Via Fratelli Cervi 201, I-20090 Segrate (MI) (Italy)

2007-04-15

The main effort of the present study is to analyze the availability and reliability of a high-performance linac (linear accelerator) conceived for Accelerator-Driven Systems (ADS) purpose and to suggest recommendations, in order both to meet the high operability goals and to satisfy the safety requirements dictated by the reactor system. Reliability Block Diagrams (RBD) approach has been considered for system modelling, according to the present level of definition of the design: component failure modes are assessed in terms of Mean Time Between Failure (MTBF) and Mean Time To Repair (MTTR), reliability and availability figures are derived, applying the current reliability algorithms. The lack of a well-established component database has been pointed out as the main issue related to the accelerator reliability assessment. The results, affected by the conservative character of the study, show a high margin for the improvement in terms of accelerator reliability and availability figures prediction. The paper outlines the viable path towards the accelerator reliability and availability enhancement process and delineates the most proper strategies. The improvement in the reliability characteristics along this path is shown as well.

Reliability studies of a high-power proton accelerator for accelerator-driven system applications for nuclear waste transmutation

International Nuclear Information System (INIS)

Burgazzi, Luciano; Pierini, Paolo

2007-01-01

The main effort of the present study is to analyze the availability and reliability of a high-performance linac (linear accelerator) conceived for Accelerator-Driven Systems (ADS) purpose and to suggest recommendations, in order both to meet the high operability goals and to satisfy the safety requirements dictated by the reactor system. Reliability Block Diagrams (RBD) approach has been considered for system modelling, according to the present level of definition of the design: component failure modes are assessed in terms of Mean Time Between Failure (MTBF) and Mean Time To Repair (MTTR), reliability and availability figures are derived, applying the current reliability algorithms. The lack of a well-established component database has been pointed out as the main issue related to the accelerator reliability assessment. The results, affected by the conservative character of the study, show a high margin for the improvement in terms of accelerator reliability and availability figures prediction. The paper outlines the viable path towards the accelerator reliability and availability enhancement process and delineates the most proper strategies. The improvement in the reliability characteristics along this path is shown as well

High-gradient electron accelerator powered by a relativisitic klystron

International Nuclear Information System (INIS)

Allen, M.A.; Boyd, J.K.; Callin, R.S.; Deruyter, H.; Eppley, K.R.; Fant, K.S.; Fowkes, W.R.; Haimson, J.; Hoag, H.A.; Hopkins, D.B.; Houck, T.; Koontz, R.F.; Lavine, T.L.; Loew, G.A.; Mecklenburg, B.; Miller, R.H.; Ruth, R.D.; Ryne, R.D.; Sessler, A.M.; Vlieks, A.E.; Wang, J.W.; Westenskow, G.A.; Yu, S.S.

1989-01-01

We have used relativistic klystron technology to extract 290 MW of peak power at 11.4 GHz from an induction linac beam, and to power a short 11.4-GHz high-gradient accelerator. We have measured rf phase stability, field emission, and the momentum spectrum of an accelerated electron beam. An average accelerating gradient of 84 MV/m has been achieved with 80 MW of relativistic klystron power

Application of radiofrequency superconductivity to accelerators for high-current ion beams

International Nuclear Information System (INIS)

Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Roche, C.T.; Sagalovsky, L.

1992-01-01

A development program is underway to apply rf superconductivity to the design of continuous-wave (cw) linear accelerators for high-current, high-brightness ion beam. During the last few years, considerable progress has been made both experimentally and theoretically toward this application. Recent tests of niobium resonators for ion acceleration have yielded average accelerating gradients as high as 18 MV/m. In an experiment with a radio-frequency quadrupole geometry, niobium was found to sustain cw peak surface electric fields as high as 128 MV/m over large (10 cm) surface areas. Theoretical studies of beam halo, cumulative beam breakup and alternating-phase focusing have also yielded important results. This paper su-summarizes the recent progress and identifies current and future work in the areas of superconducting accelerator technology for high-current ion beams

A linear accelerator power amplification system for high gradient structure research

International Nuclear Information System (INIS)

Haimson, J.; Mecklenburg, B.

1999-01-01

The ongoing development of linear collider high power RF sources and pulse compression systems has resulted in substantial progress towards a goal of providing a peak RF power level of approximately 250 MW at the input of the accelerator structure. While the immediate development and the high power testing of specialized waveguide components required for power transmission at these high levels have proceeded expeditiously due to the availability of resonant ring systems, the testing of high gradient accelerator structures at very high power levels, and the investigation of coupler cavity RF breakdown problems have, typically, been curtailed due to the unavailability of suitable 200 to 300 MW RF test facilities. We describe herein a compact, high peak power amplification system based on a dual hybrid bridge configuration that avoids the need for power splitters at the accelerator dual feed couplers, and also provides a convenient interface for installing high gradient accelerator test structures. Design parameters are presented for a proposed power amplification system that makes use of a 75 MW, 1/2 μs flat-top RF source to produce 280 MW, 1/4 μs flat-top power for testing dual feed TW experimental accelerator sections

High-Power Electron Accelerators for Space (and other) Applications

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Dinh Cong [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lewellen, John W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-05-23

This is a presentation on high-power electron accelerators for space and other applications. The main points covered are: electron beams for space applications, new designs of RF accelerators, high-power high-electron mobility transistors (HEMT) testing, and Li-ion battery design. In summary, the authors have considered a concept of 1-MeV electron accelerator that can operate up to several seconds. This concept can be extended to higher energy to produce higher beam power. Going to higher beam energy requires adding more cavities and solid-state HEMT RF power devices. The commercial HEMT have been tested for frequency response and RF output power (up to 420 W). Finally, the authors are testing these HEMT into a resonant load and planning for an electron beam test in FY17.

High power laser exciter accelerators

International Nuclear Information System (INIS)

Martin, T.H.

1975-01-01

Recent developments in untriggered oil and water switching now permit the construction of compact, high energy density pulsed power sources for laser excitation. These accelerators, developed principally for electron beam fusion studies, appear adaptable to laser excitation and will provide electron beams of 10 13 to 10 14 W in the next several years. The accelerators proposed for e-beam fusion essentially concentrate the available power from the outside edge of a disk into the central region where the electron beam is formed. One of the main problem areas, that of power flow at the vacuum diode insulator, is greatly alleviated by the multiplicity of electron beams that are allowable for laser excitation. A proposal is made whereby the disk-shaped pulsed power sections are stacked vertically to form a series of radially flowing electron beams to excite the laser gas volume. (auth)

A high performance architecture for accelerator controls

International Nuclear Information System (INIS)

Allen, M.; Hunt, S.M; Lue, H.; Saltmarsh, C.G.; Parker, C.R.C.B.

1991-01-01

The demands placed on the Superconducting Super Collider (SSC) control system due to large distances, high bandwidth and fast response time required for operation will require a fresh approach to the data communications architecture of the accelerator. The prototype design effort aims at providing deterministic communication across the accelerator complex with a response time of < 100 ms and total bandwidth of 2 Gbits/sec. It will offer a consistent interface for a large number of equipment types, from vacuum pumps to beam position monitors, providing appropriate communications performance for each equipment type. It will consist of highly parallel links to all equipment: those with computing resources, non-intelligent direct control interfaces, and data concentrators. This system will give each piece of equipment a dedicated link of fixed bandwidth to the control system. Application programs will have access to all accelerator devices which will be memory mapped into a global virtual addressing scheme. Links to devices in the same geographical area will be multiplexed using commercial Time Division Multiplexing equipment. Low-level access will use reflective memory techniques, eliminating processing overhead and complexity of traditional data communication protocols. The use of commercial standards and equipment will enable a high performance system to be built at low cost

A high performance architecture for accelerator controls

International Nuclear Information System (INIS)

Allen, M.; Hunt, S.M.; Lue, H.; Saltmarsh, C.G.; Parker, C.R.C.B.

1991-03-01

The demands placed on the Superconducting Super Collider (SSC) control system due to large distances, high bandwidth and fast response time required for operation will require a fresh approach to the data communications architecture of the accelerator. The prototype design effort aims at providing deterministic communication across the accelerator complex with a response time of <100 ms and total bandwidth of 2 Gbits/sec. It will offer a consistent interface for a large number of equipment types, from vacuum pumps to beam position monitors, providing appropriate communications performance for each equipment type. It will consist of highly parallel links to all equipments: those with computing resources, non-intelligent direct control interfaces, and data concentrators. This system will give each piece of equipment a dedicated link of fixed bandwidth to the control system. Application programs will have access to all accelerator devices which will be memory mapped into a global virtual addressing scheme. Links to devices in the same geographical area will be multiplexed using commercial Time Division Multiplexing equipment. Low-level access will use reflective memory techniques, eliminating processing overhead and complexity of traditional data communication protocols. The use of commercial standards and equipment will enable a high performance system to be built at low cost. 1 fig

Quantum Accelerators for High-performance Computing Systems

Energy Technology Data Exchange (ETDEWEB)

Humble, Travis S. [ORNL; Britt, Keith A. [ORNL; Mohiyaddin, Fahd A. [ORNL

2017-11-01

We define some of the programming and system-level challenges facing the application of quantum processing to high-performance computing. Alongside barriers to physical integration, prominent differences in the execution of quantum and conventional programs challenges the intersection of these computational models. Following a brief overview of the state of the art, we discuss recent advances in programming and execution models for hybrid quantum-classical computing. We discuss a novel quantum-accelerator framework that uses specialized kernels to offload select workloads while integrating with existing computing infrastructure. We elaborate on the role of the host operating system to manage these unique accelerator resources, the prospects for deploying quantum modules, and the requirements placed on the language hierarchy connecting these different system components. We draw on recent advances in the modeling and simulation of quantum computing systems with the development of architectures for hybrid high-performance computing systems and the realization of software stacks for controlling quantum devices. Finally, we present simulation results that describe the expected system-level behavior of high-performance computing systems composed from compute nodes with quantum processing units. We describe performance for these hybrid systems in terms of time-to-solution, accuracy, and energy consumption, and we use simple application examples to estimate the performance advantage of quantum acceleration.

Modeling high-power RF accelerator cavities with SPICE

International Nuclear Information System (INIS)

Humphries, S. Jr.

1992-01-01

The dynamical interactions between RF accelerator cavities and high-power beams can be treated on personal computers using a lumped circuit element model and the SPICE circuit analysis code. Applications include studies of wake potentials, two-beam accelerators, microwave sources, and transverse mode damping. This report describes the construction of analogs for TM mn0 modes and the creation of SPICE input for cylindrical cavities. The models were used to study continuous generation of kA electron beam pulses from a vacuum cavity driven by a high-power RF source

High current proton linear accelerators and nuclear power

International Nuclear Information System (INIS)

Tunnicliffe, P.R.; Chidley, B.G.; Fraser, J.S.

1976-01-01

This paper outlines a possible role that high-current proton linear accelerators might play as ''electrical breeders'' in the forthcoming nuclear-power economy. A high-power beam of intermediate energy protons delivered to an actinide-element target surrounded by a blanket of fertile material may produce fissile material at a competitive cost. Criteria for technical performance and, in a Canadian context, for costs are given and the major problem areas outlined not only for the accelerator and its associated rf power source but also for the target assembly. (author)

Science opportunities at high power accelerators like APT

International Nuclear Information System (INIS)

Browne, J.C.

1996-01-01

This paper presents applications of high power RF proton linear accelerators to several fields. Radioisotope production is an area in which linacs have already provided new isotopes for use in medical and industrial applications. A new type of spallation neutron source, called a long-pulse spallation source (LPSS), is discussed for application to neutron scattering and to the production and use of ultra-cold neutrons (UCN). The concept of an accelerator-driven, transmutation of nuclear waste system, based on high power RF linac technology, is presented along with its impact on spent nuclear fuels

Preventing Sudden Cardiac Death: Automated External Defibrillators in Ohio High Schools.

Science.gov (United States)

Lear, Aaron; Hoang, Minh-Ha; Zyzanski, Stephen J

2015-10-01

Ohio passed legislation in 2004 for optional public funding of automated external defibrillators (AEDs) in all Ohio high schools. To report occurrences of sudden cardiac arrest in which AEDs were used in Ohio high schools and to evaluate the adherence of Ohio high schools with AEDs to state law and published guidelines on AEDs and emergency action plans (EAPs) in schools. Cross-sectional survey. Web-based survey. A total of 264 of 827 schools that were members of the Ohio High School Athletic Association. We surveyed schools on AED use, AED maintenance, and EAPs. Twenty-five episodes of AED deployment at 22 schools over an 11-year period were reported; 8 (32%) involved students and 17 (68%) involved adults. The reported survival rate was 60% (n = 15). Most events (n = 20, 80%) in both students and adults occurred at or near athletic facilities. The annual use rate of AEDs was 0.7%. Fifty-three percent (n = 140) of schools reported having an EAP in place for episodes of cardiac arrest. Of the schools with EAPs, 57% (n = 80) reported having rehearsed them. Our data supported the placement of AEDs in high schools given the frequency of use for sudden cardiac arrest and the survival rate reported. They also suggested the need for increased awareness of recommendations for EAPs and the need to formulate and practice EAPs. School EAPs should emphasize planning for events in the vicinity of athletic facilities.

A brief history of high power RF proton linear accelerators

International Nuclear Information System (INIS)

Browne, J.C.

1996-01-01

The first mention of linear acceleration was in a paper by G. Ising in 1924 in which he postulated the acceleration of positive ions induced by spark discharges which produced electric fields in gaps between a series of open-quotes drift tubesclose quotes. Ising apparently was not able to demonstrate his concept, most likely due to the limited state of electronic devices. Ising's work was followed by a seminal paper by R. Wideroe in 1928 in which he demonstrated the first linear accelerator. Wideroe was able to accelerate sodium or potassium ions to 50 keV of energy using drift tubes connected alternately to high frequency waves and to ground. Nuclear physics during this period was interested in accelerating protons, deuterons, electrons and alpha particles and not heavy ions like sodium or potassium. To accelerate the light ions required much higher frequencies than available at that time. So linear accelerators were not pursued heavily at that time. Research continued during the 1930s but the development of high frequency RF tubes for radar applications in World War 2 opened the potential for RF linear accelerators after the war. The Berkeley laboratory of E. 0. Lawrence under the leadership of Luis Alvarez developed a new linear proton accelerator concept that utilized drift tubes that required a full RF period to pass through as compared to the earlier concepts. This development resulted in the historic Berkeley 32 MeV proton linear accelerator which incorporated the open-quotes Alvarez drift tubeclose quotes as the basic acceleration scheme using surplus 200 MHz radar components

Induction linear accelerators with high-Tc bulk superconductor lenses

International Nuclear Information System (INIS)

Matsuzawa, Hidenori; Wada, Haruhisa; Mori, Satoshi; Yamamoto, Tadashi

1991-01-01

Solenoidal coils in a one-stage induction accelerator were replaced by a high-T c bulk superconductor lens (Supertron). The accelerator postaccelerated injected electron beams to ∼ 400 keV, ∼ 0.35 kA, and ∼ 10 ns of duration time. (author)

Application of pulse power technology to ultra high energy electron accelerators

International Nuclear Information System (INIS)

Nation, J.A.

1989-01-01

The author presents in this paper a review of the application of pulse power technology to the development of high gradient electron accelerators. The technology demands are relatively modest compared to the ultra high power technology used for inertial confinement fusion drivers. With the advent of magnetic switching intense electron beams can be generated with a sufficiently high repetition rate to be of interest for high energy electron accelerator driver applications. Most of the techniques considered rely on the excitation of large amplitude waves on the beams. Within this framework there are two broad categories of accelerator, those in which the waves are directly excited in and supported by the medium and, secondly, those where the waves are used to generate radiofrequency signals which are then coupled via structures to the beam being accelerated. In what follows we shall consider both approaches. Present-day pulse power technology limits pulse durations to about 100 nsec. Consequently, if these sources are to be used, we will need to use high group velocity structures to avoid the need for short accelerator module lengths. An advantage of the short pulse duration is that the available acceleration voltage gradient increases compared to that obtained using conventional rf drivers. 19 references, 9 figures, 1 table

Research on high beam-current accelerators

International Nuclear Information System (INIS)

Keefe, D.

1981-01-01

In this review of research being undertaken at present in the US on accelerating devices and concepts of a novel nature, both non-collective systems, including high-current rf linacs and a variety of induction linacs, and also collective systems are considered. (U.K.)

SU-E-T-797: Variations of Cardiac Dose at Different Respiratory Status in CyberKnife M6â„¢ Treatment Plans for Accelerated Partial Breast Irradiation (APBI)

Energy Technology Data Exchange (ETDEWEB)

Long, S [Florida Atlantic University, Boca Raton, FL (United States); Shang, C [Boca Raton Regional Hospital, Boca Raton, FL (United States); Evans, G [Boca Raton, FL (United States); Leventouri, T [FAU, Boca Raton, FL (United States)

2015-06-15

Purpose: Cyberknife robotic assisted radiation delivery has become a choice for accelerated breast RT, while a slightly increased cardiac dose has been reported. The dose dynamics throughout the respiration cycle has scarcely been explored. This study was designed to investigate the dose changes at each respiratory phase or status during respiration cycle. Methods: Six patients with 4DCT studies and six patients with a pair of free-breathing and deep breath-hold CT sets were used for dosimetry comparisons. 4DCT sets were obtained by Siemens™ CT and its respiratory gating system, comprising of 8 phases. Standard APBI plan at 340 cGy was done per fraction per NSABP B-39/RTOG 0413 and modulated with Cyberknife M6™ on MultiPlan™5.1.2. For the purpose of this study, the tumor volume was outlined in the media-lower quadrant of the left breast. Results: Except for D5cc in plans with 4DCT, cardiac doses are significantly different between respiratory phases in well inhaled breathing phases, and more significantly in plans with BH CT. Mean cardiac doses in 100% inhalation phase were often found to be 5–15% (p< 0.02) less than those in other phases. Conclusion: Although ineligible cardiac doses are noted in APBI plans using 4D free-breathing CT and instantaneous free breathing CT series, a reduction in cardiac dose was seen for the well-inhaled phases. This provides practical guidance for cardiac dose reduction applicable with CK M6 APBR.

SU-E-T-797: Variations of Cardiac Dose at Different Respiratory Status in CyberKnife M6â„¢ Treatment Plans for Accelerated Partial Breast Irradiation (APBI)

International Nuclear Information System (INIS)

Long, S; Shang, C; Evans, G; Leventouri, T

2015-01-01

Purpose: Cyberknife robotic assisted radiation delivery has become a choice for accelerated breast RT, while a slightly increased cardiac dose has been reported. The dose dynamics throughout the respiration cycle has scarcely been explored. This study was designed to investigate the dose changes at each respiratory phase or status during respiration cycle. Methods: Six patients with 4DCT studies and six patients with a pair of free-breathing and deep breath-hold CT sets were used for dosimetry comparisons. 4DCT sets were obtained by Siemens™ CT and its respiratory gating system, comprising of 8 phases. Standard APBI plan at 340 cGy was done per fraction per NSABP B-39/RTOG 0413 and modulated with Cyberknife M6™ on MultiPlan™5.1.2. For the purpose of this study, the tumor volume was outlined in the media-lower quadrant of the left breast. Results: Except for D5cc in plans with 4DCT, cardiac doses are significantly different between respiratory phases in well inhaled breathing phases, and more significantly in plans with BH CT. Mean cardiac doses in 100% inhalation phase were often found to be 5–15% (p< 0.02) less than those in other phases. Conclusion: Although ineligible cardiac doses are noted in APBI plans using 4D free-breathing CT and instantaneous free breathing CT series, a reduction in cardiac dose was seen for the well-inhaled phases. This provides practical guidance for cardiac dose reduction applicable with CK M6 APBR

High intensity proton linear accelerator for Neutron Science Project

International Nuclear Information System (INIS)

Mizumoto, Motoharu

1999-01-01

JAERI has been proposing the Neutron Science Project (NSP) which will be composed of a high intensity proton accelerator and various research facilities. With an energy of 1.5 GeV and a beam power of 8 MW, the accelerator is required for basic research fields and nuclear waste transmutation studies. The R and D work has been carried out for the components of the accelerator. In the low energy accelerator part, a beam test with an ion source and an RFQ has been performed with a current of 80 mA and a duty factor of 10% at an energy of 2 MeV. A 1 m long high power test model of DTL has been fabricated and tested with a duty factor of 20%. In the high energy accelerator part, a superconducting (SC) linac has been selected as a main option from 100 MeV to 1.5 GeV. A test stand for SC linac cavity with equipment of cryogenics, vacuum, RF source and cavity processing and cleaning system has been prepared to test the fabrication process and physics issues. The vertical tests of β = 0.5 (145 MeV) and β = 0.89 (1.1 GeV) single cell SC cavities have been made resulting in a maximum electric field strength of 44 MV/m and 47 MV/m at 2 K, respectively. (author)

Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus

NARCIS (Netherlands)

van der Meer, Rutger W.; Rijzewijk, Luuk J.; de Jong, Hugo W. A. M.; Lamb, Hildo J.; Lubberink, Mark; Romijn, Johannes A.; Bax, Jeroen J.; de Roos, Albert; Kamp, Otto; Paulus, Walter J.; Heine, Robert J.; Lammertsma, Adriaan A.; Smit, Johannes W. A.; Diamant, Michaela

2009-01-01

Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also with an elevated risk of heart failure. We determined the effects of pioglitazone on myocardial function in relation to cardiac high-energy

High intensity linear accelerator development topics for panel discussion on ''Nuclear Energy Research and Accelerators: Future Prospects''

International Nuclear Information System (INIS)

Jameson, R.A.

1989-01-01

Two companion papers at this meeting have introduced the subject of high intensity linacs for materials research and for radioactive waste transmutation; Prof. Kaneko's paper ''Intense Proton Accelerator,'' and my paper ''Accelerator-Based Intense Neutron Source for Materials R ampersand D.'' I will expand on those remarks to briefly outline some of the extensive work that has been done at Los Alamos toward those two application areas, plus a third --- the production of tritium in an accelerator-based facility (APT--Accelerator Production of Tritium). 1 ref., 11 figs

Predicting Induced Radioactivity at High Energy Accelerators

Energy Technology Data Exchange (ETDEWEB)

Fasso, Alberto

1999-08-27

Radioactive nuclides are produced at high-energy electron accelerators by different kinds of particle interactions with accelerator components and shielding structures. Radioactivity can also be induced in air, cooling fluids, soil and groundwater. The physical reactions involved include spallations due to the hadronic component of electromagnetic showers, photonuclear reactions by intermediate energy photons and low-energy neutron capture. Although the amount of induced radioactivity is less important than that of proton accelerators by about two orders of magnitude, reliable methods to predict induced radioactivity distributions are essential in order to assess the environmental impact of a facility and to plan its decommissioning. Conventional techniques used so far are reviewed, and a new integrated approach is presented, based on an extension of methods used at proton accelerators and on the unique capability of the FLUKA Monte Carlo code to handle the whole joint electromagnetic and hadronic cascade, scoring residual nuclei produced by all relevant particles. The radiation aspects related to the operation of superconducting RF cavities are also addressed.

Cardiac tumors: optimal cardiac MR sequences and spectrum of imaging appearances.

LENUS (Irish Health Repository)

O'Donnell, David H

2012-02-01

OBJECTIVE: This article reviews the optimal cardiac MRI sequences for and the spectrum of imaging appearances of cardiac tumors. CONCLUSION: Recent technologic advances in cardiac MRI have resulted in the rapid acquisition of images of the heart with high spatial and temporal resolution and excellent myocardial tissue characterization. Cardiac MRI provides optimal assessment of the location, functional characteristics, and soft-tissue features of cardiac tumors, allowing accurate differentiation of benign and malignant lesions.

High-energy cosmic-ray acceleration

OpenAIRE

Bustamante, M; Carrillo Montoya, G; de Paula, W; Duarte Chavez, J A; Gago, A M; Hakobyan, H; Jez, P; Monroy Montañez, J A; Ortiz Velasquez, A; Padilla Cabal, F; Pino Rozas, M; Rodriguez Patarroyo, D J; Romeo, G L; Saldaña-Salazar , U J; Velasquez, M

2010-01-01

We briefly review the basics of ultrahigh-energy cosmic-ray acceleration. The Hillas criterion is introduced as a geometrical criterion that must be fulfilled by potential acceleration sites, and energy losses are taken into account in order to obtain a more realistic scenario. The different available acceleration mechanisms are presented, with special emphasis on Fermi shock acceleration and its prediction of a power-law cosmic-ray energy spectrum. We conclude that first-order Fermi accelera...

High Gradient Accelerating Structures for Carbon Therapy Linac

Energy Technology Data Exchange (ETDEWEB)

Kutsaev, Sergey; Agustsson, R.; Faillace, L.; Goel, A.; Mustapha, B.; Nassiri, A.; Ostroumov, P.; Plastun, A.; Savin, E.

2016-05-01

Carbon therapy is the most promising among techniques for cancer treatment, as it has demonstrated significant improvements in clinical efficiency and reduced toxicity profiles in multiple types of cancer through much better localization of dose to the tumor volume. RadiaBeam, in collaboration with Argonne National Laboratory, are developing an ultra-high gradient linear accelerator, Advanced Compact Carbon Ion Linac (ACCIL), for the delivery of ion-beams with end-energies up to 450 MeV/u for 12C6+ ions and 250 MeV for protons. In this paper, we present a thorough comparison of standing and travelling wave designs for high gradient S-Band accelerating structures operating with ions at varying velocities, relative to the speed of light, in the range 0.3-0.7. In this paper we will compare these types of accelerating structures in terms of RF, beam dynamics and thermo-mechanical performance.

The effectiveness of and satisfaction with high-fidelity simulation to teach cardiac surgical resuscitation skills to nurses.

Science.gov (United States)

McRae, Marion E; Chan, Alice; Hulett, Renee; Lee, Ai Jin; Coleman, Bernice

2017-06-01

There are few reports of the effectiveness or satisfaction with simulation to learn cardiac surgical resuscitation skills. To test the effect of simulation on the self-confidence of nurses to perform cardiac surgical resuscitation simulation and nurses' satisfaction with the simulation experience. A convenience sample of sixty nurses rated their self-confidence to perform cardiac surgical resuscitation skills before and after two simulations. Simulation performance was assessed. Subjects completed the Satisfaction with Simulation Experience scale and demographics. Self-confidence scores to perform all cardiac surgical skills as measured by paired t-tests were significantly increased after the simulation (d=-0.50 to 1.78). Self-confidence and cardiac surgical work experience were not correlated with time to performance. Total satisfaction scores were high (mean 80.2, SD 1.06) indicating satisfaction with the simulation. There was no correlation of the satisfaction scores with cardiac surgical work experience (τ=-0.05, ns). Self-confidence scores to perform cardiac surgical resuscitation procedures were higher after the simulation. Nurses were highly satisfied with the simulation experience. Copyright © 2016 Elsevier Ltd. All rights reserved.

High energy gain electron beam acceleration by 100TW laser

International Nuclear Information System (INIS)

Kotaki, Hideyuki; Kando, Masaki; Kondo, Shuji; Hosokai, Tomonao; Kanazawa, Shuhei; Yokoyama, Takashi; Matoba, Toru; Nakajima, Kazuhisa

2001-01-01

A laser wakefield acceleration experiment using a 100TW laser is planed at JAERI-Kansai. High quality and short pulse electron beams are necessary to accelerate the electron beam by the laser. Electron beam - laser synchronization is also necessary. A microtron with a photocathode rf-gun was prepared as a high quality electron injector. The quantum efficiency (QE) of the photocathode of 2x10 -5 was obtained. A charge of 100pC from the microtron was measured. The emittance and pulse width of the electron beam was 6π mm-mrad and 10ps, respectively. In order to produce a short pulse electron beam, and to synchronize between the electron beam and the laser pulse, an inverse free electron laser (IFEL) is planned. One of problems of LWFA is the short acceleration length. In order to overcome the problem, a Z-pinch plasma waveguide will be prepared as a laser wakefield acceleration tube for 1 GeV acceleration. (author)

High average power linear induction accelerator development

International Nuclear Information System (INIS)

Bayless, J.R.; Adler, R.J.

1987-07-01

There is increasing interest in linear induction accelerators (LIAs) for applications including free electron lasers, high power microwave generators and other types of radiation sources. Lawrence Livermore National Laboratory has developed LIA technology in combination with magnetic pulse compression techniques to achieve very impressive performance levels. In this paper we will briefly discuss the LIA concept and describe our development program. Our goals are to improve the reliability and reduce the cost of LIA systems. An accelerator is presently under construction to demonstrate these improvements at an energy of 1.6 MeV in 2 kA, 65 ns beam pulses at an average beam power of approximately 30 kW. The unique features of this system are a low cost accelerator design and an SCR-switched, magnetically compressed, pulse power system. 4 refs., 7 figs

End-expiration respiratory gating for a high-resolution stationary cardiac SPECT system

International Nuclear Information System (INIS)

Chan, Chung; Sinusas, Albert J; Liu, Chi; Harris, Mark; Le, Max; Biondi, James; Grobshtein, Yariv; Liu, Yi-Hwa

2014-01-01

Respiratory and cardiac motions can degrade myocardial perfusion SPECT (MPS) image quality and reduce defect detection and quantitative accuracy. In this study, we developed a dual respiratory and cardiac gating system for a high-resolution fully stationary cardiac SPECT scanner in order to improve the image quality and defect detection. Respiratory motion was monitored using a compressive sensor pillow connected to a dual respiratory–cardiac gating box, which sends cardiac triggers only during end-expiration phases to the single cardiac trigger input on the SPECT scanners. The listmode data were rebinned retrospectively into end-expiration frames for respiratory motion reduction or eight cardiac gates only during end-expiration phases to compensate for both respiratory and cardiac motions. The proposed method was first validated on a motion phantom in the presence and absence of multiple perfusion defects, and then applied on 11 patient studies with and without perfusion defects. In the normal phantom studies, the end-expiration gated SPECT (EXG-SPECT) reduced respiratory motion blur and increased myocardium to blood pool contrast by 51.2% as compared to the ungated images. The proposed method also yielded an average of 11.2% increase in myocardium to defect contrast as compared to the ungated images in the phantom studies with perfusion defects. In the patient studies, EXG-SPECT significantly improved the myocardium to blood pool contrast (p < 0.005) by 24% on average as compared to the ungated images, and led to improved perfusion uniformity across segments on polar maps for normal patients. For a patient with defect, EXG-SPECT improved the defect contrast and definition. The dual respiratory–cardiac gating further reduced the blurring effect, increased the myocardium to blood pool contrast significantly by 36% (p < 0.05) compared to EXG-SPECT, and further improved defect characteristics and visualization of fine structures at the expense of increased

Power Supplies for High Energy Particle Accelerators

Science.gov (United States)

Dey, Pranab Kumar

2016-06-01

The on-going research and the development projects with Large Hadron Collider at CERN, Geneva, Switzerland has generated enormous enthusiasm and interest amongst all to know about the ultimate findings on `God's Particle'. This paper has made an attempt to unfold the power supply requirements and the methodology adopted to provide the stringent demand of such high energy particle accelerators during the initial stages of the search for the ultimate particles. An attempt has also been made to highlight the present status on the requirement of power supplies in some high energy accelerators with a view that, precautionary measures can be drawn during design and development from earlier experience which will be of help for the proposed third generation synchrotron to be installed in India at a huge cost.

False alarm reduction in BSN-based cardiac monitoring using signal quality and activity type information.

Science.gov (United States)

Tanantong, Tanatorn; Nantajeewarawat, Ekawit; Thiemjarus, Surapa

2015-02-09

False alarms in cardiac monitoring affect the quality of medical care, impacting on both patients and healthcare providers. In continuous cardiac monitoring using wireless Body Sensor Networks (BSNs), the quality of ECG signals can be deteriorated owing to several factors, e.g., noises, low battery power, and network transmission problems, often resulting in high false alarm rates. In addition, body movements occurring from activities of daily living (ADLs) can also create false alarms. This paper presents a two-phase framework for false arrhythmia alarm reduction in continuous cardiac monitoring, using signals from an ECG sensor and a 3D accelerometer. In the first phase, classification models constructed using machine learning algorithms are used for labeling input signals. ECG signals are labeled with heartbeat types and signal quality levels, while 3D acceleration signals are labeled with ADL types. In the second phase, a rule-based expert system is used for combining classification results in order to determine whether arrhythmia alarms should be accepted or suppressed. The proposed framework was validated on datasets acquired using BSNs and the MIT-BIH arrhythmia database. For the BSN dataset, acceleration and ECG signals were collected from 10 young and 10 elderly subjects while they were performing ADLs. The framework reduced the false alarm rate from 9.58% to 1.43% in our experimental study, showing that it can potentially assist physicians in diagnosing a vast amount of data acquired from wireless sensors and enhance the performance of continuous cardiac monitoring.

High-output cardiac failure secondary to multiple vascular malformations in the liver: case report

International Nuclear Information System (INIS)

Spaner, S.; Demeter, S.; Lien, D.; Shapiro, J.; McCarthy, M.; Raymond, G.

2001-01-01

High-output cardiac failure is associated with several systemic illnesses, including hyperthyroidism, thiamine deficiency, severe anemia, multiple myeloma, Paget's disease of bone and Osler-Weber-Rendu syndrome. We present an unusual case of a woman with high-output cardiac failure as a result of multiple arteriovenous fistulas in the liver, most likely representing an unusual variant of Osler-Weber-Rendu syndrome (i.e., no other telangiectasias or a family history of vascular malformations was demonstrated). (author)

High Temperature Superconductor Accelerator Magnets

CERN Document Server

AUTHOR|(CDS)2079328; de Rijk, Gijs; Dhalle, Marc

2016-11-10

For future particle accelerators bending dipoles are considered with magnetic fields exceeding $20T$. This can only be achieved using high temperature superconductors (HTS). These exhibit different properties from classical low temperature superconductors and still require significant research and development before they can be applied in a practical accelerator magnet. In order to study HTS in detail, a five tesla demonstrator magnet named Feather-M2 is designed and constructed. The magnet is based on ReBCO coated conductor, which is assembled into a $10kA$ class Roebel cable. A new and optimized Aligned Block layout is used, which takes advantage of the anisotropy of the conductor. This is achieved by providing local alignment of the Roebel cable in the coil windings with the magnetic field lines. A new Network Model capable of analyzing transient electro-magnetic and thermal phenomena in coated conductor cables and coils is developed. This model is necessary to solve critical issues in coated conductor ac...

Experimental and theoretical investigation of high gradient acceleration

International Nuclear Information System (INIS)

Wurtele, J.S.; Bekefi, G.; Chen, C.; Chen, S.C.; Temkin, R.J.

1993-01-01

This report contains a technical progress summary of the research conducted under the auspices of DOE Grant No. DE-AC02-91-ER40648, ''Experimental and Theoretical Investigations of High Gradient Acceleration''. This grant supports three research tasks: Task A consists of the design, fabrication and testing of a 17GHz RF photocathode gun, which can produce 2ps electron pulses with up to 1nC of charge at 2MeV energy and at a 1OHz repetition rate. Task B supports the testing of high gradient acceleration at 33GHz structure, and Task C comprises theoretical investigations, both in support of the experimental tasks and on critical physics issues for the development of high energy linear colliders

Some problems in the technique of high-voltage testing of the accelerating tube gaps in electrostatic accelerators

International Nuclear Information System (INIS)

Romanov, V.A.; Ivanov, V.V.; Mukhametshin, V.I.; Dmitriev, E.P.; Kidalov, A.I.

1983-01-01

Problems arising during high-voltage testing and training of accelerating taubes of electrostatic accelrators are discussed. A rig and technique of the accelerating tube testing and program designed for the processing of the data obtained and sorting out of the samples investigated are described

High intensity accelerator for a wide range of applications

International Nuclear Information System (INIS)

Conard, E.M.

1994-01-01

When looking at commercial applications of accelerators from a market point of view, it appears that a common accelerator design could meet different users' needs. This would benefit both the manufacturer and the user by multiplying the number of machines sold, thus lowering their cost and improving their quality. These applications include: radioisotope production for medical imaging (positron emission tomography), industrial imaging and non-destructive testing (e.g. neutron radiography, explosive and drug detection in luggage or freight). This paper investigates the needs of the various applications and defines their common denominator to establish suitable specifications (type of particles, energy, intensity). Different accelerator types (cyclotrons, linear accelerators and electrostatic machines) are reviewed and compared on performance and estimated costs. A high intensity tandem accelerator design is studied in more detail as it seems the most appropriate candidate. ((orig.))

Highly-stabilized power supply for synchrotron accelerators. High speed, low ripple power supply

Energy Technology Data Exchange (ETDEWEB)

Sato, Kenji [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Kumada, Masayuki; Fukami, Kenji; Koseki, Shoichiro; Kubo, Hiroshi; Kanazawa, Toru

1997-02-01

In synchrotron accelerators, in order to utilize high energy beam effectively, those are operated by repeating acceleration and taking-out at short period. In order to accelerate by maintaining beam track stable, the tracking performance with the error less than 10{sup -3} in the follow-up of current is required for the power supply. Further, in order to maintain the intensity and uniformity of beam when it is taken out, very low ripple is required for output current. The power supply having such characteristics has been developed, and applied to the HIMAC and the SPring-8. As the examples of the application of synchrotrons, the accelerators for medical treatment and the generation of synchrotron radiation are described. As to the power supply for the deflection magnets and quadrupole magnets of synchrotron accelerators, the specifications of the main power supply, the method of reducing ripple, the method of improving tracking, and active filter control are reported. As to the test results, the measurement of current ripple and tracking error is shown. The lowering of ripple was enabled by common mode filter and the symmetrical connection of electromagnets, and high speed response was realized by the compensation for delay with active filter. (K.I.)

High gradient test of X-band accelerating structure at GLCTA

International Nuclear Information System (INIS)

Watanabe, K.; Higo, T.; Hayano, H.; Terunuma, N.; Saeki, T.; Kudo, N.; Sanuki, T.; Seuhara, T.

2004-01-01

GLCTA (Global Linear Collider Test Accelerator) is the high power test facility for X-band acceleration. We have installed an X-band 60cm structure in April 2004 and have been processing it for more than 3 months. Now it is under test on long-term operation. We report here the installation process and high power test result to date. (author)

Diagnostic and prognostic value of high-sensitivity cardiac troponin T in patients with syncope.

Science.gov (United States)

Christ, Michael; Geier, Felicitas; Popp, Steffen; Singler, Katrin; Smolarsky, Alexander; Bertsch, Thomas; Müller, Christian; Greve, Yvonne

2015-02-01

We examined the diagnostic and predictive value of high-sensitivity cardiac troponin T (cTnThs) in patients with syncope. We performed an analysis of consecutive patients with syncope presenting to the emergency department. The primary end point was the accuracy to diagnose a cardiac syncope. In addition, the study explored the prognostic relevance of cTnThs in patients with cardiac and noncardiac syncope. A total of 360 patients were enrolled (median age, 70.5 years; male, 55.8%; 23.9% aged >80 years). Cardiac syncope was present in 22% of patients, reflex syncope was present in 40% of patients, syncope due to orthostatic hypotension was present in 20% of patients, and unexplained syncope was present in 17.5% of patients. A total of 148 patients (41%) had cTnThs levels above the 99% confidence interval (CI) (cutoff point). The diagnostic accuracy for cTnThs levels to determine the diagnosis of cardiac syncope was quantified by the area under the curve (0.77; CI, 0.72-0.83; P value of cTnThs levels within 30 days: Patients with increased cTnThs levels had a 52% likelihood for adverse events, patients with cTnThs levels below the cutoff point had a low risk (negative predictive value, 83.5%). Increased cTnThs levels indicate adverse prognosis in patients with noncardiac causes of syncope, but not in patients with cardiac syncope being a risk factor for adverse outcome by itself. Patients with syncope presenting to the emergency department have a high proportion of life-threatening conditions. cTnThs levels show a limited diagnostic and predictive accuracy for the identification of patients with syncope at high risk. Copyright © 2015 Elsevier Inc. All rights reserved.

High quality electron beams from a laser wakefield accelerator

Energy Technology Data Exchange (ETDEWEB)

Wiggins, S M; Issac, R C; Welsh, G H; Brunetti, E; Shanks, R P; Anania, M P; Cipiccia, S; Manahan, G G; Aniculaesei, C; Ersfeld, B; Islam, M R; Burgess, R T L; Vieux, G; Jaroszynski, D A [SUPA, Department of Physics, University of Strathclyde, Glasgow (United Kingdom); Gillespie, W A [SUPA, Division of Electronic Engineering and Physics, University of Dundee, Dundee (United Kingdom); MacLeod, A M [School of Computing and Creative Technologies, University of Abertay Dundee, Dundee (United Kingdom); Van der Geer, S B; De Loos, M J, E-mail: m.wiggins@phys.strath.ac.u [Pulsar Physics, Burghstraat 47, 5614 BC Eindhoven (Netherlands)

2010-12-15

High quality electron beams have been produced in a laser-plasma accelerator driven by femtosecond laser pulses with a peak power of 26 TW. Electrons are produced with an energy up to 150 MeV from the 2 mm gas jet accelerator and the measured rms relative energy spread is less than 1%. Shot-to-shot stability in the central energy is 3%. Pepper-pot measurements have shown that the normalized transverse emittance is {approx}1{pi} mm mrad while the beam charge is in the range 2-10 pC. The generation of high quality electron beams is understood from simulations accounting for beam loading of the wakefield accelerating structure. Experiments and self-consistent simulations indicate that the beam peak current is several kiloamperes. Efficient transportation of the beam through an undulator is simulated and progress is being made towards the realization of a compact, high peak brilliance free-electron laser operating in the vacuum ultraviolet and soft x-ray wavelength ranges.

High temperature experiment for accelerator inertial fusion

International Nuclear Information System (INIS)

Lee, E.P.

1985-01-01

The High Temperature Experiment (HTE) is intended to produce temperatures of 50-100 eV in solid density targets driven by heavy ion beams from a multiple beam induction linac. The fundamental variables (particle species, energy number of beamlets, current and pulse length) must be fixed to achieve the temperature at minimum cost, subject to criteria of technical feasibility and relevance to the development of a Fusion Driver. The conceptual design begins with an assumed (radiation-limited) target temperature and uses limitations due to particle range, beamlet perveance, and target disassembly to bound the allowable values of mass number (A) and energy (E). An accelerator model is then applied to determine the minimum length accelerator, which is a guide to total cost. The accelerator model takes into account limits on transportable charge, maximum gradient, core mass per linear meter, and head-to-tail momentum variation within a pulse

Cost optimisation studies of high power accelerators

Energy Technology Data Exchange (ETDEWEB)

McAdams, R.; Nightingale, M.P.S.; Godden, D. [AEA Technology, Oxon (United Kingdom)] [and others

1995-10-01

Cost optimisation studies are carried out for an accelerator based neutron source consisting of a series of linear accelerators. The characteristics of the lowest cost design for a given beam current and energy machine such as power and length are found to depend on the lifetime envisaged for it. For a fixed neutron yield it is preferable to have a low current, high energy machine. The benefits of superconducting technology are also investigated. A Separated Orbit Cyclotron (SOC) has the potential to reduce capital and operating costs and intial estimates for the transverse and longitudinal current limits of such machines are made.

OptoDyCE: Automated system for high-throughput all-optical dynamic cardiac electrophysiology

Science.gov (United States)

Klimas, Aleksandra; Yu, Jinzhu; Ambrosi, Christina M.; Williams, John C.; Bien, Harold; Entcheva, Emilia

2016-02-01

In the last two decades, market were due to cardiac toxicity, where unintended interactions with ion channels disrupt the heart's normal electrical function. Consequently, all new drugs must undergo preclinical testing for cardiac liability, adding to an already expensive and lengthy process. Recognition that proarrhythmic effects often result from drug action on multiple ion channels demonstrates a need for integrative and comprehensive measurements. Additionally, patient-specific therapies relying on emerging technologies employing stem-cell derived cardiomyocytes (e.g. induced pluripotent stem-cell-derived cardiomyocytes, iPSC-CMs) require better screening methods to become practical. However, a high-throughput, cost-effective approach for cellular cardiac electrophysiology has not been feasible. Optical techniques for manipulation and recording provide a contactless means of dynamic, high-throughput testing of cells and tissues. Here, we consider the requirements for all-optical electrophysiology for drug testing, and we implement and validate OptoDyCE, a fully automated system for all-optical cardiac electrophysiology. We demonstrate the high-throughput capabilities using multicellular samples in 96-well format by combining optogenetic actuation with simultaneous fast high-resolution optical sensing of voltage or intracellular calcium. The system can also be implemented using iPSC-CMs and other cell-types by delivery of optogenetic drivers, or through the modular use of dedicated light-sensitive somatic cells in conjunction with non-modified cells. OptoDyCE provides a truly modular and dynamic screening system, capable of fully-automated acquisition of high-content information integral for improved discovery and development of new drugs and biologics, as well as providing a means of better understanding of electrical disturbances in the heart.

A high-power rf linear accelerator for FELS [free-electron lasers

International Nuclear Information System (INIS)

Sheffield, R.L.; Watson, J.M.

1987-01-01

This paper describes the design of a high average current rf linear accelerator suitable for driving short-wavelength free-electron lasers (FEL). It is concluded that the design of a room-temperature rf linear acelerator that can meet the stringent requirements of a high-power short-wavelength FEL appears possible. The accelerator requires the use of an advanced photoelectric injector that is under development; the accelerator components, however, do not require appreciable development. At these large beam currents, low-frequency, large-bore room-temperature cavities can be highly efficient and give all specified performance with minimal risk. 20 refs

High-quality laser-accelerated ion beams for medical applications

Energy Technology Data Exchange (ETDEWEB)

Harman, Zoltan; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Salamin, Yousef I. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); American University of Sharjah (United Arab Emirates)

2009-07-01

Cancer radiation therapy requires accelerated ion beams of high energy sharpness and a narrow spatial profile. As shown recently, linearly and radially polarized, tightly focused and thus extremely strong laser beams should permit the direct acceleration of light atomic nuclei up to energies that may offer the potentiality for medical applications. Radially polarized beams have better emittance than their linearly polarized counterparts. We put forward the direct laser acceleration of ions, once the refocusing of ion beams by external fields is solved or radially polarized laser pulses of sufficient power can be generated.

High-energy acceleration of an intense negative ion beam

International Nuclear Information System (INIS)

Takeiri, Y.; Ando, A.; Kaneko, O.

1995-02-01

A high-current H - ion beam has been accelerated with the two-stage acceleration. A large negative hydrogen ion source with an external magnetic filter produces more than 10 A of the H - ions from the grid area of 25cm x 50cm with the arc efficiency of 0.1 A/kW by seeding a small amount of cesium. The H - ion current increases according to the 3/2-power of the total beam energy. A 13.6 A of H - ion beam has been accelerated to 125 keV at the operational gas pressure of 3.4 mTorr. The optimum beam acceleration is achieved with nearly the same electric fields in the first and the second acceleration gaps on condition that the ratio of the first acceleration to the extraction electric fields is adjusted for an aspect ratio of the extraction gap. The ratio of the acceleration drain current to the H - ion current is more than 1.7. That is mainly due to the secondary electron generated by the incident H - ions on the extraction grid and the electron suppression grid. The neutralization efficiency was measured and agrees with the theoretical calculation result. (author)

High frequency single mode traveling wave structure for particle acceleration

Energy Technology Data Exchange (ETDEWEB)

Ivanyan, M.I.; Danielyan, V.A.; Grigoryan, B.A.; Grigoryan, A.H. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Tsakanian, A.V. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Technische Universität Darmstadt, Institut TEMF, 64289 Darmstadt (Germany); Tsakanov, V.M., E-mail: tsakanov@asls.candle.am [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia); Vardanyan, A.S.; Zakaryan, S.V. [CANDLE Synchrotron Research Institute, 0040 Yerevan (Armenia)

2016-09-01

The development of the new high frequency slow traveling wave structures is one of the promising directions in accomplishment of charged particles high acceleration gradient. The disc and dielectric loaded structures are the most known structures with slowly propagating modes. In this paper a large aperture high frequency metallic two-layer accelerating structure is studied. The electrodynamical properties of the slowly propagating TM{sub 01} mode in a metallic tube with internally coated low conductive thin layer are examined.

Recent developments in the application of rf superconductivity to high-brightness and high-gradient ion beam accelerators

International Nuclear Information System (INIS)

Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

1991-01-01

A development program is underway to apply rf superconductivity to the design of continuous-wave (cw) linear accelerators for high- brightness ion beams. Since the last workshop, considerable progress has been made both experimentally and theoretically toward this application. Recent tests of niobium resonators for ion acceleration have yielded average accelerating gradients as high as 18 MV/m. In an experiment with a radio-frequency quadrupole geometry, niobium was found to sustain cw peak surface electric fields as high as 128 MV/m over large (10 cm 2 ) surface areas. Theoretical studies of beam impingement and cumulative beam breakup have also yielded encouraging results. Consequently, a section of superconducting resonators and focusing elements has been designed for tests with high-current deuteron beams. In addition, considerable data pertaining to the rf properties of high-T c superconductors has been collected at rf-field amplitudes and frequencies of interest in connection with accelerator operation. This paper summarizes the recent progress and identifies current and future work in the areas of accelerator technology and superconducting materials which will build upon it

High intensity proton linear accelerator development for nuclear waste transmutation

International Nuclear Information System (INIS)

Mizumoto, M.; Hasegawa, K.; Oguri, H.; Ito, N.; Kusano, J.; Okumura, Y.; Murata, H.; Sakogawa, K.

1997-01-01

A high-intensity proton linear accelerator with an energy of 1.5 GeV and an average current of 10 mA has been proposed for various engineering tests for the transmutation system of nuclear waste by JAERI. The conceptual and optimization studies for this accelerator performed for a proper choice of operating frequency, high b structure, mechanical engineering considerations and RF source aspects are briefly described

High quality electron beams from a plasma channel guided laser wakefield accelerator

International Nuclear Information System (INIS)

Geddes, C.G.R.; Toth, Cs.; Tilborg, J. van; Esarey, E.; Schroeder, C.B.; Bruhwiler, D.; Nieter, C.; Cary, J.; Leemans, W.P.

2004-01-01

Laser driven accelerators, in which particles are accelerated by the electric field of a plasma wave driven by an intense laser, have demonstrated accelerating electric fields of hundreds of GV/m. These fields are thousands of times those achievable in conventional radiofrequency (RF) accelerators, spurring interest in laser accelerators as compact next generation sources of energetic electrons and radiation. To date however, acceleration distances have been severely limited by lack of a controllable method for extending the propagation distance of the focused laser pulse. The ensuing short acceleration distance results in low energy beams with 100% electron energy spread, limiting applications. Here we demonstrate that a relativistically intense laser can be guided by a preformed plasma density channel and that the longer propagation distance can result in electron beams of percent energy spread with low emittance and increased energy, containing >10 9 electrons above 80 MeV. The preformed plasma channel technique forms the basis of a new class of accelerators, combining beam quality comparable to RF accelerators with the high gradients of laser accelerators to produce compact tunable high brightness electron and radiation sources

Bridging the gap between high and low acceleration for planetary escape

Science.gov (United States)

Indrikis, Janis; Preble, Jeffrey C.

With the exception of the often time consuming analysis by numerical optimization, no single orbit transfer analysis technique exists that can be applied over a wide range of accelerations. Using the simple planetary escape (parabolic trajectory) mission some of the more common techniques are considered as the limiting bastions at the high and the extremely low acceleration regimes. The brachistochrone, the minimum time of flight path, is proposed as the technique to bridge the gap between the high and low acceleration regions, providing a smooth bridge over the entire acceleration spectrum. A smooth and continuous velocity requirement is established for the planetary escape mission. By using these results, it becomes possible to determine the effect of finite accelerations on mission performance and target propulsion and power system designs which are consistent with a desired mission objective.

Extracellular high-mobility group box 1 mediates pressure overload-induced cardiac hypertrophy and heart failure.

Science.gov (United States)

Zhang, Lei; Liu, Ming; Jiang, Hong; Yu, Ying; Yu, Peng; Tong, Rui; Wu, Jian; Zhang, Shuning; Yao, Kang; Zou, Yunzeng; Ge, Junbo

2016-03-01

Inflammation plays a key role in pressure overload-induced cardiac hypertrophy and heart failure, but the mechanisms have not been fully elucidated. High-mobility group box 1 (HMGB1), which is increased in myocardium under pressure overload, may be involved in pressure overload-induced cardiac injury. The objectives of this study are to determine the role of HMGB1 in cardiac hypertrophy and cardiac dysfunction under pressure overload. Pressure overload was imposed on the heart of male wild-type mice by transverse aortic constriction (TAC), while recombinant HMGB1, HMGB1 box A (a competitive antagonist of HMGB1) or PBS was injected into the LV wall. Moreover, cardiac myocytes were cultured and given sustained mechanical stress. Transthoracic echocardiography was performed after the operation and sections for histological analyses were generated from paraffin-embedded hearts. Relevant proteins and genes were detected. Cardiac HMGB1 expression was increased after TAC, which was accompanied by its translocation from nucleus to both cytoplasm and intercellular space. Exogenous HMGB1 aggravated TAC-induced cardiac hypertrophy and cardiac dysfunction, as demonstrated by echocardiographic analyses, histological analyses and foetal cardiac genes detection. Nevertheless, the aforementioned pathological change induced by TAC could partially be reversed by HMGB1 inhibition. Consistent with the in vivo observations, mechanical stress evoked the release and synthesis of HMGB1 in cultured cardiac myocytes. This study indicates that the activated and up-regulated HMGB1 in myocardium, which might partially be derived from cardiac myocytes under pressure overload, may be of crucial importance in pressure overload-induced cardiac hypertrophy and cardiac dysfunction. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Development plan of basic technology for a high intensity proton linear accelerator

International Nuclear Information System (INIS)

Mizumoto, M.

1990-01-01

The national program called OMEGA (Option Making Extra Gains from Actinide and Fission Products) has started with the aim of promoting the research and development of the new technologies for nuclear waste partitioning and transmutation. As a part of this program, Japan Atomic Energy Research Institute, JAERI, has laid out several R and D plans for accelerator based actinide transmutation. The present article first outlines the status of the high intensity proton linear accelerator. Then it describes the time schedule for the development of a high intensity proton linac, focusing on the first step development (basic technology accelerator), second step development (engineering test accelerator, and third step development (commercial plant). It also outlines the conceptual design study and preliminary design calculations for basic technology accelerator, focusing on general consideration, ion source, radio frequency quadrupole, drift tube linac, and high beta linac. (N.K.)

High voltage high brightness electron accelerators with MITL voltage adder coupled to foilless diodes

International Nuclear Information System (INIS)

Mazarakis, M.G.; Poukey, J.W.; Frost, C.A.; Shope, S.L.; Halbleib, J.A.; Turman, B.N.

1993-01-01

During the last ten years the authors have extensively studied the physics and operation of magnetically-immersed electron foilless diodes. Most of these sources were utilized as injectors to high current, high energy linear induction accelerators such as those of the RADLAC family. Recently they have experimentally and theoretically demonstrated that foilless diodes can be successfully coupled to self-magnetically insulated transmission line voltage adders to produce very small high brightness, high definition (no halo) electron beams. The RADLAC/SMILE experience opened the path to a new approach in high brightness, high energy induction accelerators. There is no beam drifting through the device. The voltage addition occurs in a center conductor, and the beam is created at the high voltage end in an applied magnetic field diode. This work was motivated by the remarkable success of the HERMES-III accelerator and the need to produce small radius, high energy, high current electron beams for air propagation studies and flash x-ray radiography. In this paper they present experimental results compared with analytical and numerical simulations in addition to design examples of devices that can produce multikiloamp electron beams of as high as 100 MV energies and radii as small as 1 mm

Theory of factors limiting high gradient operation of warm accelerating structures

Energy Technology Data Exchange (ETDEWEB)

Nusinovich, Gregory S. [Univ. of Maryland, College Park, MD (United States)

2014-07-22

This report consists of two parts. In the first part we describe a study of the heating of microprotrusions on surfaces of accelerating structures. This ;process is believed to lead to breakdown in these structures. Our study revealed that for current accelerator parameters melting should not occur due to space charge limitations of the current emitted by a protrusion. The second part describes a novel concept to develop THz range sources based on harmonic cyclotron masers for driving future colliders. This work was stimulated by a recent request of SLAC to develop high power, high-efficiency sources of sub-THz radiation for future high-gradient accelerators.

Usefulness of an accelerated transoesophageal stress echocardiography in the preoperative evaluation of high risk severely obese subjects awaiting bariatric surgery

Directory of Open Access Journals (Sweden)

Tessier Michel

2010-07-01

Full Text Available Abstract Background Severe obesity is associated with an increased risk of coronary artery disease (CAD. Bariatric surgery is an effective procedure for long term weight management as well as reduction of comorbidities. Preoperative evaluation of cardiac operative risk may often be necessary but unfortunately standard imaging techniques are often suboptimal in these subjects. The purpose of this study was to demonstrate the feasibility, safety and utility of transesophageal dobutamine stress echocardiography (TE-DSE using an adapted accelerated dobutamine infusion protocol in severely obese subjects with comorbidities being evaluated for bariatric surgery for assessing the presence of myocardial ischemia. Methods Subjects with severe obesity [body mass index (BMI >40 kg/m2] with known or suspected CAD and being evaluated for bariatric surgery were recruited. Results Twenty subjects (9M/11F, aged 50 ± 8 years (mean ± SD, weighing 141 ± 21 kg and with a BMI of 50 ± 5 kg/m2 were enrolled in the study and underwent a TE-DSE. The accelerated dobutamine infusion protocol used was well tolerated. Eighteen (90% subjects reached their target heart rate with a mean intubation time of 13 ± 4 minutes. Mean dobutamine dose was 31.5 ± 9.9 ug/kg/min while mean atropine dose was 0.5 ± 0.3 mg. TE-DSE was well tolerated by all subjects without complications including no significant arrhythmia, hypotension or reduction in blood arterial saturation. Two subjects had abnormal TE-DSE suggestive of myocardial ischemia. All patients underwent bariatric surgery with no documented cardiovascular complications. Conclusions TE-DSE using an accelerated infusion protocol is a safe and well tolerated imaging technique for the evaluation of suspected myocardial ischemia and cardiac operative risk in severely obese patients awaiting bariatric surgery. Moreover, the absence of myocardial ischemia on TE-DSE correlates well with a low operative risk of cardiac event.

High power ring methods and accelerator driven subcritical reactor application

Energy Technology Data Exchange (ETDEWEB)

Tahar, Malek Haj [Univ. of Grenoble (France)

2016-08-07

High power proton accelerators allow providing, by spallation reaction, the neutron fluxes necessary in the synthesis of fissile material, starting from Uranium 238 or Thorium 232. This is the basis of the concept of sub-critical operation of a reactor, for energy production or nuclear waste transmutation, with the objective of achieving cleaner, safer and more efficient process than today’s technologies allow. Designing, building and operating a proton accelerator in the 500-1000 MeV energy range, CW regime, MW power class still remains a challenge nowadays. There is a limited number of installations at present achieving beam characteristics in that class, e.g., PSI in Villigen, 590 MeV CW beam from a cyclotron, SNS in Oakland, 1 GeV pulsed beam from a linear accelerator, in addition to projects as the ESS in Europe, a 5 MW beam from a linear accelerator. Furthermore, coupling an accelerator to a sub-critical nuclear reactor is a challenging proposition: some of the key issues/requirements are the design of a spallation target to withstand high power densities as well as ensure the safety of the installation. These two domains are the grounds of the PhD work: the focus is on the high power ring methods in the frame of the KURRI FFAG collaboration in Japan: upgrade of the installation towards high intensity is crucial to demonstrate the high beam power capability of FFAG. Thus, modeling of the beam dynamics and benchmarking of different codes was undertaken to validate the simulation results. Experimental results revealed some major losses that need to be understood and eventually overcome. By developing analytical models that account for the field defects, one identified major sources of imperfection in the design of scaling FFAG that explain the important tune variations resulting in the crossing of several betatron resonances. A new formula is derived to compute the tunes and properties established that characterize the effect of the field imperfections on the

Study of superconducting cavities for high power proton accelerators

International Nuclear Information System (INIS)

Biarrotte, J.L.

2000-01-01

The research program on hybrid reactors has started in France in order to study the technologies allowing the transmutation of radioactive wastes thanks to a spallation neutron source supplied by a linear high intensity proton accelerator. The study of the high energy part of this accelerator (superconducting accelerator for hybrid) has started, and its aim is the design of superconducting radiofrequency cavities which make the two different sections of the accelerator (0.47 and 0.65). This thesis presents the advance of the work carried out on this topic since 1997, in particular the design and optimization of the 5-cell cavities which work at the 704.4 MHz frequency. The experimental part of the study has been carried out in parallel with the industrial fabrication (Cerca) of several prototypes of mono-cell cavities. These cavities have shown very good RF performances during the tests in vertical cryostat; the A 102 A cavity, in particular develops a Q0 of 7.10 10 (indicating very low RF losses) and reaches an accelerator field of 25 MV/m, i.e. more than two times the specified value (about 10 MV/V). Finally, a new risk analysis method for the excitation of the upper modes is proposed. This method shows in particular the uselessness of the implementation of HOM couplers on the cavities for a continuous beam use. (J.S.)

KEK/JAERI joint project on high intensity proton accelerators

International Nuclear Information System (INIS)

Nagamiya, Shoji

2002-01-01

From JFY01, which started on April 1, 2001, a new accelerator project to provide high-intensity proton beams proceeded into a construction phase. This project is conducted under a cooperation of two institutions, KEK and JAERI. The accelerator complex will provide 1 MW proton beams at 3 GeV and 0.75 MW beams at 50 GeV. The project will be completed within six years. In this article I will describe a) the project itself, b) sciences to be pursued at this new accelerator complex and c) the present status and future plans of the project. (author)

KEK/JAERI Joint Project on high-intensity proton accelerators

International Nuclear Information System (INIS)

Nagamiya, Shoji

2003-01-01

From JFY01, which started on April 1, 2001, a new accelerator project to provide high-intensity proton beams proceeded into a construction phase. This project is conducted under a cooperation of two institutions, KEK and JAERI. The accelerator complex will provide 1 MW proton beams at 3 GeV and 0.75 MW beams at 50 GeV. The project will be completed within 6 years. In this article I will describe (a) the project itself, (b) sciences to be pursued at this new accelerator complex and (c) the present status and future plans of the project

Development of High Power Vacuum Tubes for Accelerators and Plasma Heating

International Nuclear Information System (INIS)

Srivastava, Vishnu

2012-01-01

High pulsed power magnetrons and klystrons for medical and industrial accelerators, and high CW power klystrons and gyrotrons for plasma heating in tokamak, are being developed at CEERI. S-band 2.0MW pulsed tunable magnetrons of centre frequency 2856MHz and 2998 MHz were developed, and S-band 2.6MW pulsed tunable magnetron is being developed for medical LINAC, and 3MW pulsed tunable magnetron is being developed for industrial accelerator. S-band (2856MHz), 5MW pulsed klystron was developed for particle accelerator, and S-band 6MW pulsed klystron is under development for 10MeV industrial accelerator. 350MHz, 100kW (CW) klystron is being developed for proton accelerator, and C-band 250kW (CW) klystron is being developed for plasma heating. 42GHz, 200kW (CW/Long pulse) gyrotron is under development for plasma heating. Plasma filled tubes are also being developed for switching. 25kV/1kA and 40kV/3kA thyratrons were developed for high voltage high current switching in pulse modulators for magnetrons and klystrons. 25kV/3kA Pseudospark switch of current rise time of 1kA/|a-sec and pulse repetition rate of 500Hz is being developed. Plasma assisted high power microwave device is also being investigated.

Development of High Power Vacuum Tubes for Accelerators and Plasma Heating

Science.gov (United States)

Srivastava, Vishnu

2012-11-01

High pulsed power magnetrons and klystrons for medical and industrial accelerators, and high CW power klystrons and gyrotrons for plasma heating in tokamak, are being developed at CEERI. S-band 2.0MW pulsed tunable magnetrons of centre frequency 2856MHz and 2998 MHz were developed, and S-band 2.6MW pulsed tunable magnetron is being developed for medical LINAC, and 3MW pulsed tunable magnetron is being developed for industrial accelerator. S-band (2856MHz), 5MW pulsed klystron was developed for particle accelerator, and S-band 6MW pulsed klystron is under development for 10MeV industrial accelerator. 350MHz, 100kW (CW) klystron is being developed for proton accelerator, and C-band 250kW (CW) klystron is being developed for plasma heating. 42GHz, 200kW (CW/Long pulse) gyrotron is under development for plasma heating. Plasma filled tubes are also being developed for switching. 25kV/1kA and 40kV/3kA thyratrons were developed for high voltage high current switching in pulse modulators for magnetrons and klystrons. 25kV/3kA Pseudospark switch of current rise time of 1kA/|a-sec and pulse repetition rate of 500Hz is being developed. Plasma assisted high power microwave device is also being investigated.

High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy (ECT)

Science.gov (United States)

Duma, Andreas; Pal, Swatilika; Johnston, Joshua; Helwani, Mohammad A.; Bhat, Adithya; Gill, Bali; Rosenkvist, Jessica; Cartmill, Christopher; Brown, Frank; Miller, J. Philip; Scott, Mitchell G; Sanchez-Conde, Francisco; Jarvis, Michael; Farber, Nuri B.; Zorumski, Charles F.; Conway, Charles; Nagele, Peter

2017-01-01

Background While electroconvulsive therapy (ECT) is widely regarded as a life-saving and safe procedure, evidence regarding its effects on myocardial cell injury are sparse. The objective of this investigation was to determine incidence and magnitude of new cardiac troponin elevation after ECT using a novel high-sensitivity cardiac troponin I (hscTnI) assay. Methods This was a prospective cohort study in adult patients undergoing ECT in a single academic center (up to three ECT treatments per patient). The primary outcome was new hscTnI elevation after ECT, defined as an increase of hscTnI >100% after ECT compared to baseline with at least one value above the limit of quantification (10 ng/L). 12-lead ECG and hscTnI values were obtained prior to and 15–30 minutes after ECT; in a subset of patients an additional 2-hour hscTnI value was obtained. Results The final study population was 100 patients and a total of 245 ECT treatment sessions. Eight patients (8/100, 8%) experienced new hscTnI elevation after ECT with a cumulative incidence of 3.7% (9/245 treatments; one patient had two hscTnI elevations), two of whom had a non-ST-elevation myocardial infarction (incidence 2/245, 0.8%). Median hscTnI concentrations did not increase significantly after ECT. Tachycardia and/or elevated systolic blood pressure developed after approximately two thirds of ECT treatments. Conclusions ECT appears safe from a cardiac standpoint in a large majority of patients. A small subset of patients with pre-existing cardiovascular risk factors, however, may develop new cardiac troponin elevation after ECT, the clinical relevance of which is unclear in the absence of signs of myocardial ischemia. PMID:28166110

Design and applications of a pneumatic accelerator for high speed punching

International Nuclear Information System (INIS)

Yaldiz, Sueleyman; Saglam, Haci; Unsacar, Faruk; Isik, Hakan

2007-01-01

High speed forming is an important production method that requires specially designed HERF (high energy rate forming) machines. Most of the HERF machines are devices that consist of a system in which energy is stored and a differential piston mechanism is used to release the energy at high rate. In order to eliminate the usage of specially designed HERF machines and to obtain the high speed forming benefits, the accelerator which can be adapted easily onto conventional presses has been designed and manufactured in this study. The designed energy accelerator can be incorporated into mechanical press to convert the low speed operation into high-speed operation of a hammer. Expectations from this work are reduced distortion rates, increased surface quality and precise dimensions in metal forming operations. From the performance test, the accelerator is able to achieve high speed and energy which require for high speed blanking of thick sheet metals

Short-term adaptation and chronic cardiac remodelling to high altitude in lowlander natives and Himalayan Sherpa.

Science.gov (United States)

Stembridge, Mike; Ainslie, Philip N; Shave, Rob

2015-11-01

What is the topic of this review? At high altitude, the cardiovascular system must adapt in order to meet the metabolic demand for oxygen. This review summarizes recent findings relating to short-term and life-long cardiac adaptation to high altitude in the context of exercise capacity. What advances does it highlight? Both Sherpa and lowlanders exhibit smaller left ventricular volumes at high altitude; however, myocardial relaxation, as evidenced by diastolic untwist, is reduced only in Sherpa, indicating that short-term hypoxia does not impair diastolic relaxation. Potential remodelling of systolic function, as evidenced by lower left ventricular systolic twist in Sherpa, may facilitate the requisite sea-level mechanical reserve required during exercise, although this remains to be confirmed. Both short-term and life-long high-altitude exposure challenge the cardiovascular system to meet the metabolic demand for O2 in a hypoxic environment. As the demand for O2 delivery increases during exercise, the circulatory component of oxygen transport is placed under additional stress. Acute adaptation and chronic remodelling of cardiac structure and function may occur to facilitate O2 delivery in lowlanders during sojourn to high altitude and in permanent highland residents. However, our understanding of cardiac structural and functional adaption in Sherpa remains confined to a higher maximal heart rate, lower pulmonary vascular resistance and no differences in resting cardiac output. Ventricular form and function are intrinsically linked through the left ventricular (LV) mechanics that facilitate efficient ejection, minimize myofibre stress during contraction and aid diastolic recoil. Recent examination of LV mechanics has allowed detailed insight into fundamental cardiac adaptation in high-altitude Sherpa. In this symposium report, we review recent advances in our understanding of LV function in both lowlanders and Sherpa at rest and discuss the potential consequences

Increasing break-down strength of the support colomn of high-voltage accelerators

International Nuclear Information System (INIS)

Rezvykh, K.A.; Romanov, V.A.

1981-01-01

Calculation results of strength of electric field of the EG-2.5 electrostatic accelerator for the support colomn with electrodes of circular and elliptical transverse cross sections are presented. Conducted is the choice of constructing the column under the condition that the dimensions of the tank, high-voltage electrode, step between the sections and internal diameter of the colomn electrodes are not changed. The potential at the high-voltage electrode equals 2.5 MV while the average longitudinal gradient of the colomn field equals 1.25 MV/m. The support insulation colomn of the high-voltage accelerator screened by rings with transverse cross section in the form of orientation oval in some accelerators promotes obtaining higher operating voltage and at the same time increase of operation reliability at the rest unchanged dimensions of the plant because the probability of break-down between the support colomn and the tank wall decreases. The latter is especially significant for most high-energy accelerators as well as for accelerators used in national economy [ru

Compressed sensing reconstruction of cardiac cine MRI using golden angle spiral trajectories.

Science.gov (United States)

Tolouee, Azar; Alirezaie, Javad; Babyn, Paul

2015-11-01

In dynamic cardiac cine Magnetic Resonance Imaging (MRI), the spatiotemporal resolution is limited by the low imaging speed. Compressed sensing (CS) theory has been applied to improve the imaging speed and thus the spatiotemporal resolution. The purpose of this paper is to improve CS reconstruction of under sampled data by exploiting spatiotemporal sparsity and efficient spiral trajectories. We extend k-t sparse algorithm to spiral trajectories to achieve high spatio temporal resolutions in cardiac cine imaging. We have exploited spatiotemporal sparsity of cardiac cine MRI by applying a 2D+time wavelet-Fourier transform. For efficient coverage of k-space, we have used a modified version of multi shot (interleaved) spirals trajectories. In order to reduce incoherent aliasing artifact, we use different random undersampling pattern for each temporal frame. Finally, we have used nonuniform fast Fourier transform (NUFFT) algorithm to reconstruct the image from the non-uniformly acquired samples. The proposed approach was tested in simulated and cardiac cine MRI data. Results show that higher acceleration factors with improved image quality can be obtained with the proposed approach in comparison to the existing state-of-the-art method. The flexibility of the introduced method should allow it to be used not only for the challenging case of cardiac imaging, but also for other patient motion where the patient moves or breathes during acquisition. Copyright © 2015 Elsevier Inc. All rights reserved.

High-gradient compact linear accelerator

Science.gov (United States)

Carder, Bruce M.

1998-01-01

A high-gradient linear accelerator comprises a solid-state stack in a vacuum of five sets of disc-shaped Blumlein modules each having a center hole through which particles are sequentially accelerated. Each Blumlein module is a sandwich of two outer conductive plates that bracket an inner conductive plate positioned between two dielectric plates with different thicknesses and dielectric constants. A third dielectric core in the shape of a hollow cylinder forms a casing down the series of center holes, and it has a dielectric constant different that the two dielectric plates that sandwich the inner conductive plate. In operation, all the inner conductive plates are charged to the same DC potential relative to the outer conductive plates. Next, all the inner conductive plates are simultaneously shorted to the outer conductive plates at the outer diameters. The signal short will propagate to the inner diameters at two different rates in each Blumlein module. A faster wave propagates quicker to the third dielectric core across the dielectric plates with the closer spacing and lower dielectric constant. When the faster wave reaches the inner extents of the outer and inner conductive plates, it reflects back outward and reverses the field in that segment of the dielectric core. All the field segments in the dielectric core are then in unipolar agreement until the slower wave finally propagates to the third dielectric core across the dielectric plates with the wider spacing and higher dielectric constant. During such unipolar agreement, particles in the core are accelerated with gradients that exceed twenty megavolts per meter.

Particle accelerators and lasers high energy sources

International Nuclear Information System (INIS)

Watteau, J.P.

1985-04-01

Particle accelerators and lasers are to-day precious devices for physicist and engineer. Their performance and scope do not stop growing. Producing thin beams of high energy particles or photons, they are able to be very high energy sources which interact strongly with matter. Numerous applications use them: research, industry, communication, medicine, agroalimentary, defence, and soon. In this note, their operation principles are described and some examples of their use as high energy sources are given [fr

Exercise Ameliorates High Fat Diet Induced Cardiac Dysfunction by Increasing Interleukin 10

Directory of Open Access Journals (Sweden)

Varun eKesherwani

2015-04-01

Full Text Available Increasing evidence suggests that a sedentary lifestyle and a high fat diet (HFD leads to cardiomyopathy. Moderate exercise ameliorates cardiac dysfunction, however underlying molecular mechanisms are poorly understood. Increased inflammation due to induction of pro-inflammatory cytokine such as tumor necrosis factor-alpha (TNF-α and attenuation of anti-inflammatory cytokine such as interleukin10 (IL-10 contributes to cardiac dysfunction in obese and diabetics. We hypothesized that exercise training ameliorates HFD- induced cardiac dysfunction by mitigating obesity and inflammation through upregulation of IL-10 and downregulation of TNF-α. To test this hypothesis, eight week old, female C57BL/6J mice were fed with HFD and exercised (swimming 1hr/day for 5 days/week for eight weeks. The four treatment groups: normal diet (ND, HFD, HFD + exercise (HFD + Ex and ND + Ex were analyzed for mean body weight, blood glucose level, TNF-α, IL-10, cardiac fibrosis by Masson Trichrome, and cardiac dysfunction by echocardiography. Mean body weights were increased in HFD but comparatively less in HFD + Ex. The level of TNF-α was elevated and IL-10 was downregulated in HFD but ameliorated in HFD + Ex. Cardiac fibrosis increased in HFD and was attenuated by exercise in the HFD + Ex group. The percentage ejection fraction and fractional shortening were decreased in HFD but comparatively increased in HFD + Ex. There was no difference between ND and ND + Ex for the above parameters except an increase in IL-10 level following exercise. Based on these results, we conclude that exercise mitigates HFD- induced cardiomyopathy by decreasing obesity, inducing IL-10, and reducing TNF-α in mice.

False Alarm Reduction in BSN-Based Cardiac Monitoring Using Signal Quality and Activity Type Information

Directory of Open Access Journals (Sweden)

Tanatorn Tanantong

2015-02-01

Full Text Available False alarms in cardiac monitoring affect the quality of medical care, impacting on both patients and healthcare providers. In continuous cardiac monitoring using wireless Body Sensor Networks (BSNs, the quality of ECG signals can be deteriorated owing to several factors, e.g., noises, low battery power, and network transmission problems, often resulting in high false alarm rates. In addition, body movements occurring from activities of daily living (ADLs can also create false alarms. This paper presents a two-phase framework for false arrhythmia alarm reduction in continuous cardiac monitoring, using signals from an ECG sensor and a 3D accelerometer. In the first phase, classification models constructed using machine learning algorithms are used for labeling input signals. ECG signals are labeled with heartbeat types and signal quality levels, while 3D acceleration signals are labeled with ADL types. In the second phase, a rule-based expert system is used for combining classification results in order to determine whether arrhythmia alarms should be accepted or suppressed. The proposed framework was validated on datasets acquired using BSNs and the MIT-BIH arrhythmia database. For the BSN dataset, acceleration and ECG signals were collected from 10 young and 10 elderly subjects while they were performing ADLs. The framework reduced the false alarm rate from 9.58% to 1.43% in our experimental study, showing that it can potentially assist physicians in diagnosing a vast amount of data acquired from wireless sensors and enhance the performance of continuous cardiac monitoring.

Coaxial two-channel high-gradient dielectric wakefield accelerator

Directory of Open Access Journals (Sweden)

G. V. Sotnikov

2009-06-01

Full Text Available A new scheme for a dielectric wakefield accelerator is proposed that employs a cylindrical multizone dielectric structure configured as two concentric dielectric tubes with outer and inner vacuum channels for drive and accelerated bunches. Analytical and numerical studies have been carried out for such coaxial dielectric-loaded structures (CDS for high-gradient acceleration. An analytical theory of wakefield excitation by particle bunches in a multizone CDS has been formulated. Numerical calculations are presented for an example of a CDS using dielectric tubes with dielectric permittivity 5.7, having external diameters of 2.121 and 0.179 mm with inner diameters of 2.095 and 0.1 mm. An annular 5 GeV, 6 nC electron bunch with rms length of 0.035 mm energizes a wakefield on the structure axis having an accelerating gradient of ∼600  MeV/m with a transformer ratio ∼8∶1. The period of the accelerating field is ∼0.33  mm. If the width of the drive bunch channel is decreased, it is possible to obtain an accelerating gradient of >1  GeV/m while keeping the transformer ratio approximately the same. Full numerical simulations using a particle-in-cell code have confirmed results of the linear theory and furthermore have shown the important influence of the quenching wave that restricts the region of the wakefield to within several periods following the drive bunch. Numerical simulations for another example have shown nearly stable transport of drive and accelerated bunches through the CDS, using a short train of drive bunches.

KEK (High Energy Accelerator Research Organization) annual report, 2005

International Nuclear Information System (INIS)

2006-01-01

This report summarizes research activities of KEK (High Energy Accelerator Research Organization) in the fiscal year 2005. Two years have passed since the KEK was reorganized as an inter-university research institute corporation, and KEK continue to facilitate a wide range of research programs based on high-energy accelerators for users from universities. KEK consists of two research institutes, the Institute of Particle and Nuclear Studies (IPNS) and the Institute of Materials Science (IMSS); and two laboratories, the Accelerator Laboratory and the Applied Research Laboratory. KEK has been operating four major accelerator facilities in Tsukuba: the 12 GeV Proton Synchrotron (PS), the KEK B-factory (KEKB), the Photon Factory (PF), and the Electron/Positron Injector Linac. We are now engaged in the construction of the Japan Proton Accelerator Research Complex (J-PARC) in Tokai in cooperation with the Japan Atomic Energy Agency (JAEA). The J-PARC Center was established in February 2006 to take full responsibility for the operation of J-PARC. With the progress of construction, the PS ceased operation at the end of March 2006 after a history of 26 years. The task of KEK is to play a key role in the fields of elementary particle, nuclei, materials and life science as one of leading research facilities of the world. The fiscal year 2005 activities of both KEK employees and visiting researchers yielded excellent outcomes in these research fields. (J.P.N.)

Discussion of high brightness rf linear accelerators

International Nuclear Information System (INIS)

Jameson, R.A.

1987-01-01

The fundamental aspects of high-brightness rf linacs are outlined, showing the breadth and complexity of the technology and indicating that synergism with advancements in other areas is important. Areas of technology reviewed include ion sources, injectors, rf accelerator structures, beam dynamics, rf power, and automatic control

High-energy inverse free-electron laser accelerator

International Nuclear Information System (INIS)

Courant, E.D.; Pellegrini, C.; Zakowicz, W.

1985-01-01

We study the inverse free electron laser (IFEL) accelerator and show that it can accelerate electrons to the few hundred GeV region with average acceleration rates of the order of 200 meV/m. Several possible accelerating structures are analyzed, and the effect of synchrotron radiation losses is studied. The longitudinal phase stability of accelerated particles is also analyzed. A Hamiltonian description, which takes into account the dissipative features of the IFEL accelerator, is introduced to study perturbations from the resonant acceleration. Adiabatic invariants are obtained and used to estimate the change of the electron phase space density during the acceleration process

Cryogenics for high-energy particle accelerators: highlights from the first fifty years

CERN Document Server

AUTHOR|(CDS)2067931

2017-01-01

Applied superconductivity has become a key technology for high-energy particle accelerators, allowing to reach higher beam energy while containing size, capital expenditure and operating costs. Large and powerful cryogenic systems are therefore ancillary to low-temperature superconducting accelerator devices – magnets and high-frequency cavities – distributed over multi-kilometre distances and operating generally close to the normal boiling point of helium, but also above 4.2 K in supercritical and down to below 2 K in superfluid. Additionally, low-temperature operation in accelerators may also be required by considerations of ultra-high vacuum, limited stored energy and beam stability. We discuss the rationale for cryogenics in high-energy particle accelerators, review its development over the past half-century and present its outlook in future large projects, with reference to the main engineering domains of cryostat design and heat loads, cooling schemes, efficient power refrigeration and cryogenic flu...

High heat flux cooling for accelerator targets

International Nuclear Information System (INIS)

Silverman, I.; Nagler, A.

2002-01-01

Accelerator targets, both for radioisotope production and for high neutron flux sources generate very high thermal power in the target material which absorbs the particles beam. Generally, the geometric size of the targets is very small and the power density is high. The design of these targets requires dealing with very high heat fluxes and very efficient heat removal techniques in order to preserve the integrity of the target. Normal heat fluxes from these targets are in the order of 1 kw/cm 2 and may reach levels of an order of magnitude higher

Epidemiology and Outcomes After In-Hospital Cardiac Arrest After Pediatric Cardiac Surgery

Science.gov (United States)

Gupta, Punkaj; Jacobs, Jeffrey P.; Pasquali, Sara K.; Hill, Kevin D.; Gaynor, J. William; O’Brien, Sean M.; He, Max; Sheng, Shubin; Schexnayder, Stephen M.; Berg, Robert A.; Nadkarni, Vinay M.; Imamura, Michiaki; Jacobs, Marshall L.

2014-01-01

Background Multicenter data regarding cardiac arrest in children undergoing heart operations are limited. We describe epidemiology and outcomes associated with postoperative cardiac arrest in a large multiinstitutional cohort. Methods Patients younger than 18 years in the Society of Thoracic Surgeons Congenital Heart Surgery Database (2007 through 2012) were included. Patient factors, operative characteristics, and outcomes were described for patients with and without postoperative cardiac arrest. Multivariable models were used to evaluate the association of center volume with cardiac arrest rate and mortality after cardiac arrest, adjusting for patient and procedural factors. Results Of 70,270 patients (97 centers), 1,843 (2.6%) had postoperative cardiac arrest. Younger age, lower weight, and presence of preoperative morbidities (all p < 0.0001) were associated with cardiac arrest. Arrest rate increased with procedural complexity across common benchmark operations, ranging from 0.7% (ventricular septal defect repair) to 12.7% (Norwood operation). Cardiac arrest was associated with significant mortality risk across procedures, ranging from 15.4% to 62.3% (all p < 0.0001). In multivariable analysis, arrest rate was not associated with center volume (odds ratio, 1.06; 95% confidence interval, 0.71 to 1.57 in low- versus high-volume centers). However, mortality after cardiac arrest was higher in low-volume centers (odds ratio, 2.00; 95% confidence interval, 1.52 to 2.63). This association was present for both high- and low-complexity operations. Conclusions Cardiac arrest carries a significant mortality risk across the stratum of procedural complexity. Although arrest rates are not associated with center volume, lower-volume centers have increased mortality after cardiac arrest. Further study of mechanisms to prevent cardiac arrest and to reduce mortality in those with an arrest is warranted. PMID:25443018

High performance current controller for particle accelerator magnets supply

DEFF Research Database (Denmark)

Maheshwari, Ram Krishan; Bidoggia, Benoit; Munk-Nielsen, Stig

2013-01-01

The electromagnets in modern particle accelerators require high performance power supply whose output is required to track the current reference with a very high accuracy (down to 50 ppm). This demands very high bandwidth controller design. A converter based on buck converter topology is used...

Electron Acceleration by High Power Radio Waves in the Ionosphere

Science.gov (United States)

Bernhardt, Paul

2012-10-01

At the highest ERP of the High Altitude Auroral Research Program (HAARP) facility in Alaska, high frequency (HF) electromagnetic (EM) waves in the ionosphere produce artificial aurora and electron-ion plasma layers. Using HAARP, electrons are accelerated by high power electrostatic (ES) waves to energies >100 times the thermal temperature of the ambient plasma. These ES waves are driven by decay of the pump EM wave tuned to plasma resonances. The most efficient acceleration process occurs near the harmonics of the electron cyclotron frequency in earth's magnetic field. Mode conversion plays a role in transforming the ES waves into EM signals that are recorded with ground receivers. These diagnostic waves, called stimulated EM emissions (SEE), show unique resonant signatures of the strongest electron acceleration. This SEE also provides clues about the ES waves responsible for electron acceleration. The electron gas is accelerated by high frequency modes including Langmuir (electron plasma), upper hybrid, and electron Bernstein waves. All of these waves have been identified in the scattered EM spectra as downshifted sidebands of the EM pump frequency. Parametric decay is responsible low frequency companion modes such as ion acoustic, lower hybrid, and ion Bernstein waves. The temporal evolution of the scattered EM spectrum indicates development of field aligned irregularities that aid the mode conversion process. The onset of certain spectral features is strongly correlated with glow plasma discharge structures that are both visible with the unaided eye and detectable using radio backscatter techniques at HF and UHF frequencies. The primary goals are to understand natural plasma layers, to study basic plasma physics in a unique ``laboratory with walls,'' and to create artificial plasma structures that can aid radio communications.

A multi-region assessment of population rates of cardiac catheterization and yield of high-risk coronary artery disease

Directory of Open Access Journals (Sweden)

Clement Fiona M

2011-11-01

Full Text Available Abstract Background There is variation in cardiac catheterization utilization across jurisdictions. Previous work from Alberta, Canada, showed no evidence of a plateau in the yield of high-risk disease at cardiac catheterization rates as high as 600 per 100,000 population suggesting that the optimal rate is higher. This work aims 1 To determine if a previously demonstrated linear relationship between the yield of high-risk coronary disease and cardiac catheterization rates persists with contemporary data and 2 to explore whether the linear relationship exists in other jurisdictions. Methods Detailed clinical information on all patients undergoing cardiac catheterization in 3 Canadian provinces was available through the Alberta Provincial Project for Outcomes Assessment in Coronary Heart (APPROACH disease and partner initiatives in British Columbia and Nova Scotia. Population rates of catheterization and high-risk coronary disease detection for each health region in these three provinces, and age-adjusted rates produced using direct standardization. A mixed effects regression analysis was performed to assess the relationship between catheterization rate and high-risk coronary disease detection. Results In the contemporary Alberta data, we found a linear relationship between the population catheterization rate and the high-risk yield. Although the yield was slightly less in time period 2 (2002-2006 than in time period 1(1995-2001, there was no statistical evidence of a plateau. The linear relationship between catheterization rate and high-risk yield was similarly demonstrated in British Columbia and Nova Scotia and appears to extend, without a plateau in yield, to rates over 800 procedures per 100,000 population. Conclusions Our study demonstrates a consistent finding, over time and across jurisdictions, of linearly increasing detection of high-risk CAD as population rates of cardiac catheterization increase. This internationally-relevant finding

Advanced approaches to high intensity laser-driven ion acceleration

International Nuclear Information System (INIS)

Henig, Andreas

2010-01-01

Since the pioneering work that was carried out 10 years ago, the generation of highly energetic ion beams from laser-plasma interactions has been investigated in much detail in the regime of target normal sheath acceleration (TNSA). Creation of ion beams with small longitudinal and transverse emittance and energies extending up to tens of MeV fueled visions of compact, laser-driven ion sources for applications such as ion beam therapy of tumors or fast ignition inertial con finement fusion. However, new pathways are of crucial importance to push the current limits of laser-generated ion beams further towards parameters necessary for those applications. The presented PhD work was intended to develop and explore advanced approaches to high intensity laser-driven ion acceleration that reach beyond TNSA. In this spirit, ion acceleration from two novel target systems was investigated, namely mass-limited microspheres and nm-thin, free-standing diamond-like carbon (DLC) foils. Using such ultrathin foils, a new regime of ion acceleration was found where the laser transfers energy to all electrons located within the focal volume. While for TNSA the accelerating electric field is stationary and ion acceleration is spatially separated from laser absorption into electrons, now a localized longitudinal field enhancement is present that co-propagates with the ions as the accompanying laser pulse pushes the electrons forward. Unprecedented maximum ion energies were obtained, reaching beyond 0.5 GeV for carbon C 6+ and thus exceeding previous TNSA results by about one order of magnitude. When changing the laser polarization to circular, electron heating and expansion were shown to be efficiently suppressed, resulting for the first time in a phase-stable acceleration that is dominated by the laser radiation pressure which led to the observation of a peaked C 6+ spectrum. Compared to quasi-monoenergetic ion beam generation within the TNSA regime, a more than 40 times increase in

Advanced approaches to high intensity laser-driven ion acceleration

Energy Technology Data Exchange (ETDEWEB)

Henig, Andreas

2010-04-26

Since the pioneering work that was carried out 10 years ago, the generation of highly energetic ion beams from laser-plasma interactions has been investigated in much detail in the regime of target normal sheath acceleration (TNSA). Creation of ion beams with small longitudinal and transverse emittance and energies extending up to tens of MeV fueled visions of compact, laser-driven ion sources for applications such as ion beam therapy of tumors or fast ignition inertial con finement fusion. However, new pathways are of crucial importance to push the current limits of laser-generated ion beams further towards parameters necessary for those applications. The presented PhD work was intended to develop and explore advanced approaches to high intensity laser-driven ion acceleration that reach beyond TNSA. In this spirit, ion acceleration from two novel target systems was investigated, namely mass-limited microspheres and nm-thin, free-standing diamond-like carbon (DLC) foils. Using such ultrathin foils, a new regime of ion acceleration was found where the laser transfers energy to all electrons located within the focal volume. While for TNSA the accelerating electric field is stationary and ion acceleration is spatially separated from laser absorption into electrons, now a localized longitudinal field enhancement is present that co-propagates with the ions as the accompanying laser pulse pushes the electrons forward. Unprecedented maximum ion energies were obtained, reaching beyond 0.5 GeV for carbon C{sup 6+} and thus exceeding previous TNSA results by about one order of magnitude. When changing the laser polarization to circular, electron heating and expansion were shown to be efficiently suppressed, resulting for the first time in a phase-stable acceleration that is dominated by the laser radiation pressure which led to the observation of a peaked C{sup 6+} spectrum. Compared to quasi-monoenergetic ion beam generation within the TNSA regime, a more than 40 times

Technical development of high intensity proton accelerators in Japan Atomic Energy Research Institute (JAERI)

International Nuclear Information System (INIS)

Mizumoto, Motoharu

1995-01-01

Science and Technology Agency decided 'Options making extra gains of actinides and fission products (OMEGA)' and to promote the related researches. Also in JAERI, the research on the group separation method for separating transuranic elements, strontium and cesium from high level radioactive wastes has been carried out since the beginning of 1970s. Also the concept of the fast reactors using minor actinide mixture fuel is being established, and the accelerator annihilation treatment utilizing the nuclear spallation reaction by high energy protons has been examined. In this report, from the viewpoint of the application of accelerators to atomic energy field, the annihilation treatment method by the nuclear spallation reaction utilizing high intensity proton accelerators, the plan of the various engineering utilization of proton beam, and the development of accelerators in JAERI are described. The way of thinking on the annihilation treatment of radioactive waste, the system using fast neutrons, the way of thinking on the development of high intensity proton accelerator technology, the steps of the development, the research and development for constructing the basic technology accelerator, 2 MeV beam acceleration test, the basic technology accelerator utilization facility and so on are reported. (K.I.)

High voltage performance of BARC-TIFR Pelletron Accelerator

Energy Technology Data Exchange (ETDEWEB)

Surendran, P.; Ansari, Q.N.; Nair, J.P., E-mail: surendra@tifr.res.in [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai (India); and others

2014-07-01

The 14 UD Pelletron Accelerator at TIFR, Mumbai is operational since its inception in 1988. It was decided to impart enough time for high voltage conditioning to achieve higher operational voltage. Prior to this, comprehensive works such as replacing all the sputter ion pumps and Titanium sublimation pumps across the accelerator tube with new or refurbished ones and replacement of Alumina balls in the SF{sub 6} drier with fresh balls were carried out. High voltage conditioning of each module was done. Further conditioning of two modules at a time in overlapping mode improved the terminal voltage. As a result of this rigorous conditioning Terminal voltage of 12.6 MV was achieved and beam has been delivered to users at 12 MV terminal. Details of this effort will be presented in this paper. (author)

High voltage performance of BARC-TIFR Pelletron Accelerator

International Nuclear Information System (INIS)

Surendran, P.; Ansari, Q.N.; Nair, J.P.

2014-01-01

The 14 UD Pelletron Accelerator at TIFR, Mumbai is operational since its inception in 1988. It was decided to impart enough time for high voltage conditioning to achieve higher operational voltage. Prior to this, comprehensive works such as replacing all the sputter ion pumps and Titanium sublimation pumps across the accelerator tube with new or refurbished ones and replacement of Alumina balls in the SF_6 drier with fresh balls were carried out. High voltage conditioning of each module was done. Further conditioning of two modules at a time in overlapping mode improved the terminal voltage. As a result of this rigorous conditioning Terminal voltage of 12.6 MV was achieved and beam has been delivered to users at 12 MV terminal. Details of this effort will be presented in this paper. (author)

SLAC High Gradient Testing of a KEK X-Band Accelerator Structure

International Nuclear Information System (INIS)

Loewen, Rod

2000-01-01

The high accelerating gradients required for future linear colliders demands a better study of field emission and RF breakdown in accelerator structures. Changes in structure geometry, vacuum pumping, fabrication methods, and surface finish can all potentially impact the conditioning process, dark current emission, and peak RF power handling capability. Recent tests at SLAC of KEK's ''M2'' travelling wave x-band accelerator section provides an opportunity to investigate some of these effects by comparing its performance to previously high power tested structures at SLAC. In addition to studying ultimate power limitations, this test also demonstrates the use of computer automated conditioning to reach practical, achievable gradients

Defining the Intrinsic Cardiac Risks of Operations to Improve Preoperative Cardiac Risk Assessments.

Science.gov (United States)

Liu, Jason B; Liu, Yaoming; Cohen, Mark E; Ko, Clifford Y; Sweitzer, Bobbie J

2018-02-01

Current preoperative cardiac risk stratification practices group operations into broad categories, which might inadequately consider the intrinsic cardiac risks of individual operations. We sought to define the intrinsic cardiac risks of individual operations and to demonstrate how grouping operations might lead to imprecise estimates of perioperative cardiac risk. Elective operations (based on Common Procedural Terminology codes) performed from January 1, 2010 to December 31, 2015 at hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program were studied. A composite measure of perioperative adverse cardiac events was defined as either cardiac arrest requiring cardiopulmonary resuscitation or acute myocardial infarction. Operations' intrinsic cardiac risks were derived from mixed-effects models while controlling for patient mix. Resultant risks were sorted into low-, intermediate-, and high-risk categories, and the most commonly performed operations within each category were identified. Intrinsic operative risks were also examined using a representative grouping of operations to portray within-group variation. Sixty-six low, 30 intermediate, and 106 high intrinsic cardiac risk operations were identified. Excisional breast biopsy had the lowest intrinsic cardiac risk (overall rate, 0.01%; odds ratio, 0.11; 95% CI, 0.02 to 0.25) relative to the average, whereas aorto-bifemoral bypass grafting had the highest (overall rate, 4.1%; odds ratio, 6.61; 95% CI, 5.54 to 7.90). There was wide variation in the intrinsic cardiac risks of operations within the representative grouping (median odds ratio, 1.40; interquartile range, 0.88 to 2.17). A continuum of intrinsic cardiac risk exists among operations. Grouping operations into broad categories inadequately accounts for the intrinsic cardiac risk of individual operations.

High current pulsed ion inductor accelerator for destruction of radioactive wastes

Energy Technology Data Exchange (ETDEWEB)

Korenev, S A; Puzynin, I V; Samojlov, V N; Sissakyan, A N [Joint Institute for Nuclear Research, Dubna (Russian Federation)

1997-12-31

A new high-current pulsed linear induction accelerator proposed for application in beam-driven transmutation technologies is described. The accelerator consists of an ion injector, of ion separation and induction accelerating systems, and of an output system for extracting an ion beam into open air. An ion source with explosive ion emission, capable of producing various kinds of ions, is used as an injector. The ion separator exploits a pulsed magnetic system. The induction acceleration structure includes inductors with amorphous iron cores. Imbedded magnetic elements assure the ion beam transport. Main parameters of the accelerator are given in the paper and the design of an ion injector is discussed in more detail. (J.U.). 3 figs., 3 refs.

High current pulsed ion inductor accelerator for destruction of radioactive wastes

International Nuclear Information System (INIS)

Korenev, S.A.; Puzynin, I.V.; Samojlov, V.N.; Sissakyan, A.N.

1996-01-01

A new high-current pulsed linear induction accelerator proposed for application in beam-driven transmutation technologies is described. The accelerator consists of an ion injector, of ion separation and induction accelerating systems, and of an output system for extracting an ion beam into open air. An ion source with explosive ion emission, capable of producing various kinds of ions, is used as an injector. The ion separator exploits a pulsed magnetic system. The induction acceleration structure includes inductors with amorphous iron cores. Imbedded magnetic elements assure the ion beam transport. Main parameters of the accelerator are given in the paper and the design of an ion injector is discussed in more detail. (J.U.). 3 figs., 3 refs

Medium energy high intensity proton accelerator (MEHIPA): Reference Design Report (RDR) Ver. 1.0

International Nuclear Information System (INIS)

2016-11-01

Recent progress in accelerator technology has made it possible to use a proton accelerator to produce nuclear energy. In an accelerator-driven system (ADS), a high-intensity proton accelerator is used to produce protons of around 1 GeV energy, which strike a target such as lead or tungsten to produce spallation neutrons. ADS can be used to produce power, incinerate minor actinides and long-lived fission products, and for the utilization of thorium as an alternative nuclear fuel. The accelerator for ADS has to produce high energy (1 GeV) protons, and deliver tens of milli amperes of beam current with minimum (< 1 nA/m) beam loss for hands-on maintenance of the accelerator. This makes the development of accelerators for ADS very challenging. In India, it is planned to take a staged approach towards development of the requisite accelerator technology, and it is planned to develop the accelerator in three phases: 20 MeV, 200 MeV and 1 GeV. This report presents a reference design report for the Medium Energy High Intensity Proton Accelerator (MEHIPA) which will accelerate the beam to 200 MeV. The linac consists of a 3 MeV normal conducting RFQ followed by three families of superconducting Single Spoke Resonators (SSR) to accelerate the beam to 200 MeV. The major elements of the physics design of MEHIPA, as well as layouts and specifications of the major accelerator sub-systems are presented in this report. (author)

Practical aspects of shielding high-energy particle accelerators

International Nuclear Information System (INIS)

Thomas, R.H.; Univ. of California, Berkeley, CA

1993-09-01

The experimental basis of shielding design for high-energy accelerators that has been established over the past thirty years is described. Particular emphasis is given to the design of large accelerators constructed underground. The first data obtained from cosmic-ray physics were supplemented by basic nuclear physics. When these data proved insufficient, experiments were carried out and interpreted by several empirical formulae -- the most successful of which has been the Moyer Model. This empirical model has been used successfully to design the shields of most synchrotrons currently in operation, and is still being used in preliminary design and to check the results of neutron transport calculations. Accurate shield designs are needed to reduce external radiation levels during accelerator operations and to minimize environmental impacts such as open-quotes skyshineclose quotes and the production of radioactivity in groundwater. Examples of the cost of minimizing such environmental impacts are given

Effect of high image compression on the reproducibility of cardiac Sestamibi reporting

International Nuclear Information System (INIS)

Thomas, P.; Allen, L.; Beuzeville, S.

1999-01-01

Full text: Compression algorithms have been mooted to minimize storage space and transmission times of digital images. We assessed the impact of high-level lousy compression using JPEG and wavelet algorithms on image quality and reporting accuracy of cardiac Sestamibi studies. Twenty stress/rest Sestamibi cardiac perfusion studies were reconstructed into horizontal short, vertical long and horizontal long axis slices using conventional methods. Each of these six sets of slices were aligned for reporting and saved (uncompressed) as a bitmap. This bitmap was then compressed using JPEG compression, then decompressed and saved as a bitmap for later viewing. This process was repeated using the original bitmap and wavelet compression. Finally, a second copy of the original bitmap was made. All 80 bitmaps were randomly coded to ensure blind reporting. The bitmaps were read blinded and by consensus of 2 experienced nuclear medicine physicians using a 5-point scale and 25 cardiac segments. Subjective image quality was also reported using a 3-point scale. Samples of the compressed images were also subtracted from the original bitmap for visual comparison of differences. Results showed an average compression ratio of 23:1 for wavelet and 13:1 for JPEG. Image subtraction showed only very minor discordance between the original and compressed images. There was no significant difference in subjective quality between the compressed and uncompressed images. There was no significant difference in reporting reproducibility of the identical bitmap copy, the JPEG image and the wavelet image compared with the original bitmap. Use of the high compression algorithms described had no significant impact on reporting reproducibility and subjective image quality of cardiac Sestamibi perfusion studies

Safety and efficacy of high-dose melphalan and auto-SCT in patients with AL amyloidosis and cardiac involvement.

Science.gov (United States)

Girnius, S; Seldin, D C; Meier-Ewert, H K; Sloan, J M; Quillen, K; Ruberg, F L; Berk, J L; Doros, G; Sanchorawala, V

2014-03-01

In Ig light chain (AL) amyloidosis, cardiac involvement is associated with worse prognosis and increased treatment-related complications. In this retrospective cohort study, we assessed survival, hematologic and cardiac responses to high-dose melphalan and auto-SCT (HDM/SCT) in patients with AL amyloidosis and cardiac involvement, stratified by cardiac biomarkers brain natriuretic peptide and Troponin I, analogous to the Mayo cardiac staging. Forty-seven patients underwent HDM/SCT based upon functional measures; six patients had modified cardiac stage I disease, seventeen had modified cardiac stage II disease and twenty-four had modified cardiac stage III disease. Treatment-related mortality was 4% for all patients and 8% for patients with stage III disease. Three-year survival was 88% and EFS was 47%; these did not differ by stage. By intention-to-treat analysis, 27% of patients achieved a hematologic complete response and 32% a very good partial response, of whom 70 and 45%, respectively, have not required additional therapy at 36 months. Cardiac response was achieved in 53% of patients. We conclude that with appropriate patient selection and a risk-adapted treatment approach, HDM/SCT is safe and effective in patients with AL amyloidosis and cardiac involvement.

Choice of initial operating parameters for high average current linear accelerators

International Nuclear Information System (INIS)

Batchelor, K.

1976-01-01

Recent emphasis on alternative energy sources together with the need for intense neutron sources for testing of materials for CTR has resulted in renewed interest in high current (approximately 100 mA) c.w. proton and deuteron linear accelerators. In desinging an accelerator for such high currents, it is evident that beam losses in the machine must be minimized, which implies well matched beams, and that adequate acceptance under severe space charge conditions must be met. An investigation is presented of the input parameters to an Alvarez type drift-tube accelerator resulting from such factors. The analysis indicates that an accelerator operating at a frequency of 50 MHz is capable of accepting deuteron currents of about 0.4 amperes and proton currents of about 1.2 amperes. These values depend critically on the assumed values of beam emittance and on the ability to properly ''match'' this to the linac acceptance

High-quality electron beam generation in a proton-driven hollow plasma wakefield accelerator

Science.gov (United States)

Li, Y.; Xia, G.; Lotov, K. V.; Sosedkin, A. P.; Hanahoe, K.; Mete-Apsimon, O.

2017-10-01

Simulations of proton-driven plasma wakefield accelerators have demonstrated substantially higher accelerating gradients compared to conventional accelerators and the viability of accelerating electrons to the energy frontier in a single plasma stage. However, due to the strong intrinsic transverse fields varying both radially and in time, the witness beam quality is still far from suitable for practical application in future colliders. Here we demonstrate the efficient acceleration of electrons in proton-driven wakefields in a hollow plasma channel. In this regime, the witness bunch is positioned in the region with a strong accelerating field, free from plasma electrons and ions. We show that the electron beam carrying the charge of about 10% of 1 TeV proton driver charge can be accelerated to 0.6 TeV with a preserved normalized emittance in a single channel of 700 m. This high-quality and high-charge beam may pave the way for the development of future plasma-based energy frontier colliders.

Cardiac and vascular imaging with snapshot FLASH MR imaging

International Nuclear Information System (INIS)

Matthaei, D.; Haase, A.; Norris, D.; Leibfritz, D.; Henrich, D.; Duhmke, E.

1989-01-01

Acceleration of fast low-angle-shot (FLASH) MR imaging to about 200 msec measuring time on dedicated MR systems is called snapshot FLASH MR imaging. It snaps real-time series of MR images of the MR relaxation and of physiologic motions with nearly absent motion and susceptibility artifacts. Results in animals (4.7T) and human volunteers (2.0T) show plain vascular and cardiac snapshot FLASH MR images obtained as single shot, triggered reconstructed motion, or real-time films. The reduction of artifacts and the high resolution (triggered, three-dimensional moving heart images are possible) result in favorable applications in myocardial and great vascular disease

High current pulsed ion inductor accelerator for destruction of radioactive wastes

Energy Technology Data Exchange (ETDEWEB)

Korenev, S.A.; Puzynin, I.V.; Samoilov, V.N.; Sissakian, A.N. [Joint Inst. for Nuclear Research, Dubna (Russian Federation)

1997-09-01

The project of a high current pulsed linear ion accelerator is described in this paper. The accelerator consists of an ion injector, a system of charge and energy separation, an inductor accelerator and an output system. The ion source with explosive ion emission can produce all kinds of ions. The separation system includes a pulsed magnetic system. The inductors are based on amorphous iron with inside magnetic elements. 3 refs., 3 figs.

High current pulsed ion inductor accelerator for destruction of radioactive wastes

International Nuclear Information System (INIS)

Korenev, S.A.; Puzynin, I.V.; Samoilov, V.N.; Sissakian, A.N.

1997-01-01

The project of a high current pulsed linear ion accelerator is described in this paper. The accelerator consists of an ion injector, a system of charge and energy separation, an inductor accelerator and an output system. The ion source with explosive ion emission can produce all kinds of ions. The separation system includes a pulsed magnetic system. The inductors are based on amorphous iron with inside magnetic elements. 3 refs., 3 figs

Final Report for 'Modeling Electron Cloud Diagnostics for High-Intensity Proton Accelerators'

International Nuclear Information System (INIS)

Veitzer, Seth A.

2009-01-01

Electron clouds in accelerators such as the ILC degrade beam quality and limit operating efficiency. The need to mitigate electron clouds has a direct impact on the design and operation of these accelerators, translating into increased cost and reduced performance. Diagnostic techniques for measuring electron clouds in accelerating cavities are needed to provide an assessment of electron cloud evolution and mitigation. Accurate numerical modeling of these diagnostics is needed to validate the experimental techniques. In this Phase I, we developed detailed numerical models of microwave propagation through electron clouds in accelerating cavities with geometries relevant to existing and future high-intensity proton accelerators such as Project X and the ILC. Our numerical techniques and simulation results from the Phase I showed that there was a high probability of success in measuring both the evolution of electron clouds and the effects of non-uniform electron density distributions in Phase II.

Program for Plasma-Based Concepts for Future High Energy Accelerators

International Nuclear Information System (INIS)

Katsouleas, Thomas C.; Muggli, Patric

2003-01-01

OAK B204 Program for Plasma-Based Concepts for Future High Energy Accelerators. The progress made under this program in the period since November 15, 2002 is reflected in this report. The main activities for this period were to conduct the first run of the E-164 high-gradient wakefield experiment at SLAC, to prepare for run 2 and to continue our collaborative effort with CERN to model electron cloud interactions in circular accelerators. Each of these is described. Also attached to this report are papers that were prepared or appeared during this period

High gradient test of the C-band choke-mode type accelerating structure

International Nuclear Information System (INIS)

Inagaki, T.; Shintake, T.; Baba, H.; Togawa, K.; Onoe, K.; Marechal, X.; Takashima, T.; Takahashi, S.; Matsumoto, H.

2004-01-01

The C-band (5712 MHz) choke-mode type accelerating structure will be used for SPring-8 Compact SASE-FEL Source (SCSS). To make the accelerator length short, we designed the field gradient as high as 40 MV/m. Since it is higher gradient than other traditional electron accelerators, we have to carefully check its performance (RF breakdown, dark current emission, etc.) in the high gradient test stand. The first experiment will be scheduled in this summer. In this paper, we will describe the preparation progress for the test. (author)

High-power, solid-state rf source for accelerator cavities

International Nuclear Information System (INIS)

Vaughan, D.R.; Mols, G.E.; Reid, D.W.; Potter, J.M.

1985-01-01

During the past few years the Defense and Electronics Center of Westinghouse Electric Corporation has developed a solid-state, 250-kW peak, rf amplifier for use with the SPS-40 radar system. This system has a pulse length of 60 μs and operates across the frequency band from 400 to 450 MHz. Because of the potential use of such a system as an rf source for accelerator applications, a collaborative experiment was initiated between Los Alamos National Laboratory and Westinghouse to simulate the resonant load conditions of an accelerator cavity. This paper describes the positive results of that experiment as well as the solid-state amplifier architecture. It also explores the future of high-power, solid-state amplifiers as rf sources for accelerator structures

High power testing oa ANL X-band dielectric-loaded accelerating structures

International Nuclear Information System (INIS)

Power, J. G.; Gai, W.; Jing, C.; Konecny, R.; Gold, S. H.; Kinkead, A. K.

2002-01-01

In the second phase of a program to develop a compact accelerator based on a dielectric-loaded accelerating structure, we have conducted high power tests on a traveling-wave and a standing-wave prototype. Indications are that the traveling-wave structure achieved an accelerating gradient of 3-5 MV/m before the input coupling window failed, while the standing wave structure was poorly matched at high power due to contamination of copper residue on its coupling window. To solve both of these problems, a new method for coupling RF into the structures has been developed. The new couplers and the rest of the modular structure are currently under construction and will be tested at the Naval Research Laboratory shortly

Van-de-Graaf accelerator operation with laser source of highly-charged heavy ions

International Nuclear Information System (INIS)

Barabash, L.S.; Golubev, A.A.; Koshkarev, S.G.; Krechet, K.I.; Sharkov, B.Y.; Shumshurov, A.V.

1988-01-01

Multicharged ions (Z = +1 divided-by +10) of practically any elements of the periodical table have been generated by the laser source based on a simple in operation and fabrication laser. One of the features of the laser source is that the energy needed for plasma heating is transported to the target from a great distance. In this case the target can be placed under high voltage or in a magnetic field. These advantages of the laser source are particularly important for its application in the Van-de-Graaf accelerator, where absence of resonance units allows to accelerate ions with any charge-to-mass ratio. The goal of this paper consists in designing a laser source of highly- charged heavy ions in the Van-de-Graaf accelerator and in measuring charge spectra of the accelerated ion beam. The peculiarities of this accelerator are taken into account in the discussion of the source scheme. Such peculiarities include potential up to 5 MV on the high-voltage conductor, where the ion source is placed, and high up to 15 atm gas environment pressure

Cardiac dose sparing and avoidance techniques in breast cancer radiotherapy

International Nuclear Information System (INIS)

Shah, Chirag; Badiyan, Shahed; Berry, Sameer; Khan, Atif J.; Goyal, Sharad; Schulte, Kevin; Nanavati, Anish; Lynch, Melanie; Vicini, Frank A.

2014-01-01

Breast cancer radiotherapy represents an essential component in the overall management of both early stage and locally advanced breast cancer. As the number of breast cancer survivors has increased, chronic sequelae of breast cancer radiotherapy become more important. While recently published data suggest a potential for an increase in cardiac events with radiotherapy, these studies do not consider the impact of newer radiotherapy techniques commonly utilized. Therefore, the purpose of this review is to evaluate cardiac dose sparing techniques in breast cancer radiotherapy. Current options for cardiac protection/avoidance include (1) maneuvers that displace the heart from the field such as coordinating the breathing cycle or through prone patient positioning, (2) technological advances such as intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT), and (3) techniques that treat a smaller volume around the lumpectomy cavity such as accelerated partial breast irradiation (APBI), or intraoperative radiotherapy (IORT). While these techniques have shown promise dosimetrically, limited data on late cardiac events exist due to the difficulties of long-term follow up. Future studies are required to validate the efficacy of cardiac dose sparing techniques and may use surrogates for cardiac events such as biomarkers or perfusion imaging

High intensity proton operation at the Brookhaven AGS accelerator complex

International Nuclear Information System (INIS)

Ahrens, L.A.; Blaskiewicz, M.; Bleser, E.; Brennan, J.M.; Gardner, C.; Glenn, J.W.; Onillon, E.; Reece, R.K.; Roser, T.; Soukas, A.

1994-01-01

With the completion of the AGS rf upgrade, and the implementation of a transition open-quotes jumpclose quotes, all of accelerator systems were in place in 1994 to allow acceleration of the proton intensity available from the AGS Booster injector to AGS extraction energy and delivery to the high energy users. Beam commissioning results with these new systems are presented. Progress in identifying and overcoming other obstacles to higher intensity are given. These include a careful exploration of the stopband strengths present on the AGS injection magnetic porch, and implementation of the AGS single bunch transverse dampers throughout the acceleration cycle

History of the development and manufacture of Czechoslovak high-frequency linear electron accelerators

International Nuclear Information System (INIS)

Cerny, R.

2007-01-01

The paper is structured as follows: History of linear accelerators worldwide (beginnings); Development of the Czechoslovak high-frequency linear electron accelerator (Layout and working principle; The first model of the accelerator and the Faculty of Technical and Nuclear Physics and cooperation with the Research Institute for Vacuum Electronics (VUVET); Continuing development of the accelerator at VUVET); Construction of linear accelerators at VUVET and their application (Construction of the accelerating unit; UR 4/1200 accelerator for radiation technology tests at VUVET; UR 4PR ('LUPUR') accelerator for the Nuclear Research Institute at Rez; UR 4/1200 technological accelerator for the Nuclear Research Institute at Rez; LPR4 accelerator for the Hungarian Academy of Sciences; L 4/1200 accelerators for the Research Institute of Cables and Insulators in Bratislava, CKD Semiconductors in Prague, Animal Feed Research Institute at Ivanka pri Dunaji, and Synthesia Semtin). Appendix contains paragraphs devoted to the Accelerator Dept. staff and equipment, key accelerator spare parts, and radiation safety at the accelerator department, (P.A.)

Thermally Induced Ultra High Cycle Fatigue of Copper Alloys of the High Gradient Accelerating Structures

CERN Document Server

Heikkinen, Samuli; Wuensch, Walter

2010-01-01

In order to keep the overall length of the compact linear collider (CLIC), currently being studied at the European Organization for Nuclear Research (CERN), within reasonable limits, i.e. less than 50 km, an accelerating gradient above 100 MV/m is required. This imposes considerable demands on the materials of the accelerating structures. The internal surfaces of these core components of a linear accelerator are exposed to pulsed radio frequency (RF) currents resulting in cyclic thermal stresses expected to cause surface damage by fatigue. The designed lifetime of CLIC is 20 years, which results in a number of thermal stress cycles of the order of 2.33•1010. Since no fatigue data existed in the literature for CLIC parameter space, a set of three complementary experiments were initiated: ultra high cycle mechanical fatigue by ultrasound, low cycle fatigue by pulsed laser irradiation and low cycle thermal fatigue by high power microwaves, each test representing a subset of the original problem. High conductiv...

Perspectives on stem cell therapy for cardiac regeneration. Advances and challenges.

Science.gov (United States)

Choi, Sung Hyun; Jung, Seok Yun; Kwon, Sang-Mo; Baek, Sang Hong

2012-01-01

Ischemic heart disease (IHD) accelerates cardiomyocyte loss, but the developing stem cell research could be useful for regenerating a variety of tissue cells, including cardiomyocytes. Diverse sources of stem cells for IHD have been reported, including embryonic stem cells, induced pluripotent stem cells, skeletal myoblasts, bone marrow-derived stem cells, mesenchymal stem cells, and cardiac stem cells. However, stem cells have unique advantages and disadvantages for cardiac tissue regeneration, which are important considerations in determining the specific cells for improving cell survival and long-term engraftment after transplantation. Additionally, the dosage and administration method of stem cells need to be standardized to increase stability and efficacy for clinical applications. Accordingly, this review presents a summary of the stem cell therapies that have been studied for cardiac regeneration thus far, and discusses the direction of future cardiac regeneration research for stem cells.

Nuclear design aspect of the Korean high intensity proton accelerator project

Energy Technology Data Exchange (ETDEWEB)

Chang, Jonghwa; Song, Tae-Yung [Korea Atomic Energy Research Inst., Yusong, Taejon (Korea, Republic of)

1998-11-01

A plan to construct a high current proton accelerator has been proposed by KAERI. We are presenting the required nuclear design to support the project as well as a brief overview of the proposed proton accelerator. The target and core design is highlighted to show feasibility of incineration of minor actinides from the spent fuel of light water reactors. Radiation shielding and activation analyses are also important for the design and the license of the accelerator. (author)

To the problem of reliability of high-voltage accelerators for industrial purposes

International Nuclear Information System (INIS)

Al'bertinskij, B.I.; Svin'in, M.P.; Tsepakin, S.G.

1979-01-01

Statistical data characterizing the reliability of ELECTRON and AVRORA-2 type accelerators are presented. Used as a reliability index was the mean time to failure of the main accelerator units. The analysis of accelerator failures allowed a number of conclusions to be drawn. The high failure rate level is connected with inadequate training of the servicing personnel and a natural period of equipment adjustment. The mathematical analysis of the failure rate showed that the main responsibility for insufficient high reliability rests with selenium diodes which are employed in the high voltage power supply. Substitution of selenium diodes by silicon ones increases time between failures. It is shown that accumulation and processing of operational statistical data will permit more accurate prediction of the reliability of produced high-voltage accelerators, make it possible to cope with the problems of planning optimal, in time, preventive inspections and repair, and to select optimal safety factors and test procedures n time, preventive inspections and repair, and to select optimal safety factors and test procedures n time, prevent

Initial Efficacy of a Cardiac Rehabilitation Transition Program: Cardiac TRUST

Science.gov (United States)

Zullo, Melissa; Boxer, Rebecca; Moore, Shirley M.

2012-01-01

Patients recovering from cardiac events are increasingly using postacute care, such as home health care and skilled nursing facility services. The purpose of this pilot study was to test the initial efficacy, feasibility, and safety of a specially designed postacute care transitional rehabilitation intervention for cardiac patients. Cardiac Transitional Rehabilitation Using Self- Management Techniques (Cardiac TRUST) is a family-focused intervention that includes progressive low-intensity walking and education in self-management skills to facilitate recovery following a cardiac event. Using a randomized two-group design, exercise self-efficacy, steps walked, and participation in an outpatient cardiac rehabilitation program were compared in a sample of 38 older adults; 17 who received the Cardiac TRUST program and 21 who received usual care only. At discharge from postacute care, the intervention group had a trend for higher levels of self-efficacy for exercise outcomes (X=39.1, SD=7.4) than the usual care group (X=34.5; SD=7.0) (t-test 1.9, p=.06). During the 6 weeks following discharge, compared with the usual care group, the intervention group had more attendance in out-patient cardiac rehabilitation (33% compared to 11.8%, F=7.1, p=.03) and a trend toward more steps walked during the first week (X=1,307, SD=652 compared to X=782, SD=544, t-test 1.8, p=.07). The feasibility of the intervention was better for the home health participants than for those in the skilled nursing facility and there were no safety concerns. The provision of cardiac-focused rehabilitation during postacute care has the potential to bridge the gap in transitional services from hospitalization to outpatient cardiac rehabilitation for these patients at high risk for future cardiac events. Further evidence of the efficacy of Cardiac TRUST is warranted. PMID:22084960

Poisson simulation for high voltage terminal of test stand for 1MV electrostatic accelerator

Energy Technology Data Exchange (ETDEWEB)

Park, Sae-Hoon; Kim, Jeong-Tae; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Yu-Seok [Dongguk Univ.., Gyeongju (Korea, Republic of)

2014-10-15

KOMAC provide ion beam to user which energy range need to expand to MeV range and develop 1 MV electrostatic accelerator. The specifications of the electrostatic accelerator are 1MV acceleration voltage, 10 mA peak current and variable gas ion. We are developing test stand before set up 1 MV electrostatic accelerator. The test stand voltage is 300 kV and operating time is 8 hours. The test stand is consist of 300 kV high voltage terminal, DC-AC-DC inverter, power supply device inside terminal, 200MHz RF power, 5 kV extraction power supply, 300 kV accelerating tube and vacuum system.. The beam measurement system and beam dump will be installed next to accelerating tube. Poisson code simulation results of the high voltage terminal are presented in this paper. Poisson code has been used to calculate the electric field for high voltage terminal. The results of simulation were verified with reasonable results. The poisson code structure could be apply to the high voltage terminal of the test stand.

Poisson simulation for high voltage terminal of test stand for 1MV electrostatic accelerator

International Nuclear Information System (INIS)

Park, Sae-Hoon; Kim, Jeong-Tae; Kwon, Hyeok-Jung; Cho, Yong-Sub; Kim, Yu-Seok

2014-01-01

KOMAC provide ion beam to user which energy range need to expand to MeV range and develop 1 MV electrostatic accelerator. The specifications of the electrostatic accelerator are 1MV acceleration voltage, 10 mA peak current and variable gas ion. We are developing test stand before set up 1 MV electrostatic accelerator. The test stand voltage is 300 kV and operating time is 8 hours. The test stand is consist of 300 kV high voltage terminal, DC-AC-DC inverter, power supply device inside terminal, 200MHz RF power, 5 kV extraction power supply, 300 kV accelerating tube and vacuum system.. The beam measurement system and beam dump will be installed next to accelerating tube. Poisson code simulation results of the high voltage terminal are presented in this paper. Poisson code has been used to calculate the electric field for high voltage terminal. The results of simulation were verified with reasonable results. The poisson code structure could be apply to the high voltage terminal of the test stand

Post-acceleration of laser driven protons with a compact high field linac

Science.gov (United States)

Sinigardi, Stefano; Londrillo, Pasquale; Rossi, Francesco; Turchetti, Giorgio; Bolton, Paul R.

2013-05-01

We present a start-to-end 3D numerical simulation of a hybrid scheme for the acceleration of protons. The scheme is based on a first stage laser acceleration, followed by a transport line with a solenoid or a multiplet of quadrupoles, and then a post-acceleration section in a compact linac. Our simulations show that from a laser accelerated proton bunch with energy selection at ~ 30MeV, it is possible to obtain a high quality monochromatic beam of 60MeV with intensity at the threshold of interest for medical use. In the present day experiments using solid targets, the TNSA mechanism describes accelerated bunches with an exponential energy spectrum up to a cut-off value typically below ~ 60MeV and wide angular distribution. At the cut-off energy, the number of protons to be collimated and post-accelerated in a hybrid scheme are still too low. We investigate laser-plasma acceleration to improve the quality and number of the injected protons at ~ 30MeV in order to assure efficient post-acceleration in the hybrid scheme. The results are obtained with 3D PIC simulations using a code where optical acceleration with over-dense targets, transport and post-acceleration in a linac can all be investigated in an integrated framework. The high intensity experiments at Nara are taken as a reference benchmarks for our virtual laboratory. If experimentally confirmed, a hybrid scheme could be the core of a medium sized infrastructure for medical research, capable of producing protons for therapy and x-rays for diagnosis, which complements the development of all optical systems.

Cardiac Magnetic Resonance Imaging Predictors of Short-Term Outcomes after High Risk Coronary Surgery.

Science.gov (United States)

Sheriff, Mohammed J; Mouline, Omar; Hsu, Chijen; Grieve, Stuart M; Wilson, Michael K; Bannon, Paul G; Vallely, Michael P; Puranik, Rajesh

2016-06-01

The euroSCORE II is a widely used pre-coronary artery bypass graft surgery (CAGS) risk score, but its predictive power lacks the specificity to predict outcomes in high-risk patients (surgery case mix, revascularisation techniques and related outcomes in recent years. We investigated the utility of Cardiac Magnetic Resonance Imaging (CMRI) in predicting immediate and six-week outcomes after CAGS. Fifty-two consecutive patients with high euroSCORE II (>16) and left ventricular (LV) dysfunction (magnetic resonance imaging parameters were assessed in patients who either had complications immediately post-surgery (n=35), six weeks post-surgery (n=20) or were uncomplicated. The average age of patients recruited was 69±5 years with high euroSCORE II (22±4) and low 2D-echocardiography LV ejection fraction (38%±2%). Cardiac magnetic resonance imaging results demonstrated that those with immediate complications had higher LV scar/infarct burden as a proportion of LV mass (17±3% vs 10±3%; p=0.04) with lower circumferential relaxation index (2.5±0.46 vs 2.8±0.56; p=0.05) compared to those with no complications. Early mortality from surgery was 17% (n=9) and was associated with lower RV stroke volume (55±12 vs 68±18; p=0.03) and higher LV infarct scar/burden (18±2% vs 10±2%, p=0.04). Cardiac magnetic resonance imaging showed patients with complications at six weeks post-surgery had higher LV scar/infarct burden (14.5±2% vs 6.8±2%, p=0.03) compared to those without complications. Cardiac magnetic resonance imaging preoperative LV and RV parameters are valuable in assessing the likelihood of successful outcomes from CAGS in high-risk patients with LV dysfunction. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

Acceleration of high charge density electron beams in the SLAC linac

International Nuclear Information System (INIS)

Sheppard, J.C.; Clendenin, J.E.; Jobe, R.K.; Lueth, V.G.; Millich, A.; Ross, M.C.; Seeman, J.T.; Stiening, R.F.

1984-01-01

The SLAC Linear Collider (SLC) will require both electron and positron beams of very high charge density and low emittance to be accelerated to about 50 GeV in the SLAC 3-km linac. The linac is in the process of being improved to meet this requirement. The program to accelerate an electron beam of high charge density through the first third of the SLC linac is described and the experimental results are discussed. 7 references, 5 figures

Comprehensive cardiac rehabilitation

DEFF Research Database (Denmark)

Kruse, Marie; Hochstrasser, Stefan; Zwisler, Ann-Dorthe O

2006-01-01

OBJECTIVES: The costs of comprehensive cardiac rehabilitation are established and compared to the corresponding costs of usual care. The effect on health-related quality of life is analyzed. METHODS: An unprecedented and very detailed cost assessment was carried out, as no guidelines existed...... and may be as high as euro 1.877. CONCLUSIONS: Comprehensive cardiac rehabilitation is more costly than usual care, and the higher costs are not outweighed by a quality of life gain. Comprehensive cardiac rehabilitation is, therefore, not cost-effective....

Superconductor Requirements and Characterization for High Field Accelerator Magnets

Energy Technology Data Exchange (ETDEWEB)

Barzi, E.; Zlobin, A. V.

2015-05-01

The 2014 Particle Physics Project Prioritization Panel (P5) strategic plan for U.S. High Energy Physics (HEP) endorses a continued world leadership role in superconducting magnet technology for future Energy Frontier Programs. This includes 10 to 15 T Nb₃Sn accelerator magnets for LHC upgrades and a future 100 TeV scale pp collider, and as ultimate goal that of developing magnet technologies above 20 T based on both High Temperature Superconductors (HTS) and Low Temperature Superconductors (LTS) for accelerator magnets. To achieve these objectives, a sound conductor development and characterization program is needed and is herein described. This program is intended to be conducted in close collaboration with U.S. and International labs, Universities and Industry.

A high-current racetrack induction accelerator

International Nuclear Information System (INIS)

Mondelli, A.; Roberson, C.W.

1983-01-01

In this paper, the energy and system scaling laws of the Racetrack Induction Accelerator are determined and its operating principles are discussed. This device is a cyclic accelerator that is capable of multi-kiloamp operation. Long pulse induction linac technology is used to obtain short acceleration times. The accelerator consists of a long-pulse linear induction module and a racetrack beam transport system. For detailed studies of the particle dynamics in a racetrack, a numerical model is required to integrate the fully-relativistic single-particle equations of motion in an externally applied magnetic field. The numerical model is a compromise between the need for a large rotational transform and the need for a reasonable volume within the separatrix

Annotated bibliography on high-intensity linear accelerators

International Nuclear Information System (INIS)

Jameson, R.A.; Roybal, E.U.

1978-01-01

A technical bibliography covering subjects important to the design of high-intensity beam transport systems and linear accelerators is presented. Space charge and emittance growth are stressed. Subject and author concordances provide cross-reference to detailed citations, which include an abstract and notes on the material. The bibliography resides in a computer database that can be searched for key words and phrases

High-speed hydrogen pellet acceleration using an electromagnetic railgun system

International Nuclear Information System (INIS)

Onozuka, M.; Oda, Y.

1997-01-01

Using a low electric energy railgun system, solid hydrogen pellet acceleration test have been conducted to investigate the application of the electromagnetic railgun system for high-speed pellet injection into fusion plasmas. Pneumatically pre-accelerated hydrogen pellets measuring 3 mm in diameter and 4-9 mm in length were successfully accelerated by a railgun system that uses a laser-induced plasma armature formation. A 2 m long single railgun with ceramic insulators accelerated th hydrogen pellet to 2.6 kms -1 with a supplied energy of 1.7 kJ. The average acceleration rate and the energy conversion coefficient were improved to about 1.6 x 10 6 ms -2 and 0.37%, which is 1.6 times and three times as large as that using a railgun with plastic insulators, respectively. Furthermore, using the 1 m long augment railgun with ceramic insulators, the energy conversion coefficient was improved to about 0.55% while the acceleration rate was increased to 2.4 x 10 6 ms -2 . The highest hydrogen pellet velocity attained was about 2.3 kms -1 for the augment railgun under an energy supply of 1.1 kJ. Based on the findings, it is expected that the acceleration efficiency and the pellet velocity can be further improved by using a longer augment railgun with ceramic insulators and by applying an optimal power supply. (orig.)

A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.

Science.gov (United States)

Carbone, Salvatore; Mauro, Adolfo G; Mezzaroma, Eleonora; Kraskauskas, Donatas; Marchetti, Carlo; Buzzetti, Raffaella; Van Tassell, Benjamin W; Abbate, Antonio; Toldo, Stefano

2015-11-01

Heart failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, exercise intolerance and cardiac dysfunction. Unhealthy diet has been associated with increased risk of obesity and heart disease, but whether it directly affects cardiac function, and promotes the development and progression of HF is unknown. We fed 8-week old male or female CD-1 mice with a standard diet (SD) or a diet rich in saturated fat and sugar, resembling a "Western" diet (WD). Cardiac systolic and diastolic function was measured at baseline and 4 and 8 weeks by Doppler echocardiography, and left ventricular (LV) end-diastolic pressure (EDP) by cardiac catheterization prior to sacrifice. An additional group of mice received WD for 4 weeks followed by SD (wash-out) for 8 weeks. WD-fed mice experienced a significant decreased in LV ejection fraction (LVEF), reflecting impaired systolic function, and a significant increase in isovolumetric relaxation time (IRT), myocardial performance index (MPI), and LVEDP, showing impaired diastolic function, without any sex-related differences. Switching to a SD after 4 weeks of WD partially reversed the cardiac systolic and diastolic dysfunction. A diet rich in saturated fat and sugars (WD) impairs cardiac systolic and diastolic function in the mouse. Further studies are required to define the mechanism through which diet affects cardiac function, and whether dietary interventions can be used in patients with, or at risk for, HF. Published by Elsevier Ireland Ltd.

When is reacquisition necessary due to high extra-cardiac uptake in myocardial perfusion scintigraphy?

DEFF Research Database (Denmark)

Johansen, Allan; Lomsky, Milan; Gerke, Oke

2013-01-01

Technetium-labeled agents, which are most often used for assessing myocardial perfusion in myocardial perfusion scintigraphy (MPS), are cleared by the liver and excreted by the biliary system. Spillover from extra-cardiac activity into the myocardium, especially the inferior wall, might conceal d...... defects and lower the diagnostic accuracy of the study. The objective was to determine rules of thumb for when reacquisition is useful due to high extra-cardiac uptake, i.e., when interpretation of the studies was affected by poor image quality....

Choice of initial operating parameters for high average current linear accelerators

International Nuclear Information System (INIS)

Batchelor, K.

1976-01-01

In designing an accelerator for high currents it is evident that beam losses in the machine must be minimized, which implies well matched beams, and that adequate acceptance under severe space charge conditions must be met. This paper investigates the input parameters to an Alvarez type drift-tube accelerator resulting from such factors

High energy electron acceleration with PW-class laser system

International Nuclear Information System (INIS)

Nakanii, N.; Kondo, K.; Yabuuchi, T.; Tsuji, K.; Kimura, K.; Fukumochi, S.; Kashihara, M.; Tanimoto, T.; Nakamura, H.; Ishikura, T.; Kodama, R.; Mima, K.; Tanaka, K. A.; Mori, Y.; Miura, E.; Suzuki, S.; Asaka, T.; Yanagida, K.; Hanaki, H.; Kobayashi, T.

2008-01-01

We performed electron acceleration experiment with PW-class laser and a plasma tube, which was created by imploding a hollow polystyrene cylinder. In this experiment, electron energies in excess of 600 MeV have been observed. Moreover, the spectra of a comparatively high-density plasma ∼10 19 cm -3 had a bump around 10 MeV. Additionally, we performed the absolute sensitivity calibration of imaging plate for 1 GeV electrons from the injector Linac of Spring-8 in order to evaluate absolute number of GeV-class electrons in the laser acceleration experiment

Current state of X-band accelerating structure high gradient test. Be held at high energy accelerator organization on April 15, 2005

International Nuclear Information System (INIS)

Watanabe, Ken; Higo, Toshiyasu

2005-01-01

XTF (X-band Test Facility, Old name is GLCTA) is the high gradient test facility for X-band acceleration. We have installed an X-band 60cm structure (KX01) in the April 2004 and have been processing it for more than 10 months. Now it is under test on long-term operation. We report here the high gradient test result to date. (author)

The UCLA/SLAC Ultra-High Gradient Cerenkov Wakefield Accelerator Experiment

CERN Document Server

Thompson, Matthew C; Hogan, Mark; Ischebeck, Rasmus; Muggli, Patric; Rosenzweig, James E; Scott, A; Siemann, Robert; Travish, Gil; Walz, Dieter; Yoder, Rodney

2005-01-01

An experiment is planned to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range. This new UCLA/SLAC collaboration will take advantage of the unique SLAC FFTB electron beam and its demonstrated ultra-short pulse lengths and high currents (e.g., sz = 20 μm at Q = 3 nC). The electron beam will be focused down and sent through varying lengths of fused silica capillary tubing with two different sizes: ID = 200 μm / OD = 325 μm and ID = 100 μm / OD = 325 μm. The pulse length of the electron beam will be varied in order to alter the accelerating gradient and probe the breakdown threshold of the dielectric structures. In addition to breakdown studies, we plan to collect and measure coherent Cerenkov radiation emitted from the capillary tube to gain information about the strength of the accelerating fields. Status and progress on the experiment are reported.

High current pulsed linear ion accelerators for inertial fusion applications

International Nuclear Information System (INIS)

Humphries, S. Jr.; Yonas, G.; Poukey, J.W.

1978-01-01

Pulsed ion beams have a number of advantages for use as inertial fusion drivers. Among these are classical interaction with targets and good efficiency of production. As has been pointed out by members of the accelerator community, multistage accelerators are attractive in this context because of lower current requirements, low power flow per energy conversion stage and low beam divergence at higher ion energies. On the other hand, current transport limits in conventional accelerators constrain them to the use of heavy ions at energies much higher than those needed to meet the divergence requirements, resulting in large, costly systems. We have studied methods of neutralizing ion beams with electrons within the accelerator volume to achieve higher currents. The aim is to arrive at an inexpensive accelerator that can advantageously use existing pulsed voltage technology while being conservative enough to achieve a high repetition rate. Typical output parameters for reactor applications would be an 0 + beam of 30 kA at 300 MeV. We will describe reactor scaling studies and the physics of neutralized linear accelerators using magnetic fields to control the electron dynamics. Recent results are discussed from PULSELAC, a five stage multikiloampere device being tested at Sandia Laboratories

Numerical simulation on range of high-energy electron moving in accelerator target

International Nuclear Information System (INIS)

Shao Wencheng; Sun Punan; Dai Wenjiang

2008-01-01

In order to determine the range of high-energy electron moving in accelerator target, the range of electron with the energy range of 1 to 100 MeV moving in common target material of accelerator was calculated by Monte-Carlo method. Comparison between the calculated result and the published data were performed. The results of Monte-Carlo calculation are in good agreement with the published data. Empirical formulas were obtained for the range of high-energy electron with the energy range of 1 to 100 MeV in common target material by curve fitting, offering a series of referenced data for the design of targets in electron accelerator. (authors)

New initiatives for producing high current electron accelerators

International Nuclear Information System (INIS)

Faehl, R.J.; Keinigs, R.K.; Pogue, E.W.

1996-01-01

New classes of compact electron accelerators able to deliver multi-kiloamperes of pulsed 10-50 MeV electron beams are being studied. One class is based upon rf linac technology with dielectric-filled cavities. For materials with ε/ε o >>1, the greatly increased energy storage permits high current operation. The second type is a high energy injected betatron. Circulating current limits scale as Β 2 γ 3

Conceptual study of high power proton linac for accelerator driven subcritical nuclear power system

CERN Document Server

Yu Qi; Ouyang Hua Fu; Xu Tao Guang

2001-01-01

As a prior option of the next generation of energy source, the accelerator driven subcritical nuclear power system (ADS) can use efficiently the uranium and thorium resource, transmute the high-level long-lived radioactive wastes and raise nuclear safety. The ADS accelerator should provide the proton beam with tens megawatts. The superconducting linac is a good selection of ADS accelerator because of its high efficiency and low beam loss rate. The ADS accelerator presented by the consists of a 5 MeV radio-frequency quadrupole, a 100 MeV independently phased superconducting cavity linac and a 1 GeV elliptical superconducting cavity linac. The accelerating structures and main parameters are determined and the research and development plan is considered

Development of a RAMI model for LANSCE and high power APT accelerators

International Nuclear Information System (INIS)

Tallerico, P.J.

1994-01-01

Assessment of the reliability, availability, maintainability and inspectability (RAMI) of all high power, high cost systems is important to justify and improve the cost effectiveness of these systems. For the very large (over 100 MW) accelerator systems associated with APT, a RAMI model is very valuable in guiding the design and allocation of resources. A RAMI model of an existing machine is also valuable, since machine improvement funds must be allocated to increase the availability by the largest amount. The authors have developed a RAMI model using the critical subsystems of the LANSCE accelerator and beam delivery complex as an example and to evaluate the effectiveness for estimating reliability and beam availability. LAMPF and LANSCE together provide most of the features required for the accelerator and beam delivery part of a high-power APT machine, but LANSCE is pulsed, rather than CW. This complex is capable of a 1-MW average power H - beam, and it is the most powerful proton accelerator in the US built to date

Design concept of radiation control system for the high intensity proton accelerator facility

Energy Technology Data Exchange (ETDEWEB)

Miyamoto, Yukihiro; Ikeno, Koichi; Akiyama, Shigenori; Harada, Yasunori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2002-11-01

Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics. (author)

Ionizing wave via high-power HF acceleration

OpenAIRE

Mishin, Evgeny; Pedersen, Todd

2010-01-01

Recent ionospheric modification experiments with the 3.6 MW transmitter at the High Frequency Active Auroral Research Program (HAARP) facility in Alaska led to discovery of artificial ionization descending from the nominal interaction altitude in the background F-region ionosphere by ~60 km. This paper presents a physical model of an ionizing wavefront created by suprathermal electrons accelerated by the HF-excited plasma turbulence.

Radioactive airborne species formed in the air in high energy accelerator tunnels

International Nuclear Information System (INIS)

Kondo, K.

2005-01-01

Many radioactive airborne species have been observed in the air of high energy accelerator tunnels during machine operation. Radiation protection against these induced airborne radioactivities is one of the key issues for radiation safety, especially at high-energy and high-intense proton accelerators such as the J-PARC (Japan Proton Accelerator Research Complex, Joint project of KEK and JAERI), which is now under construction at the TOKAI site of JAERI. Information on the chemical forms and particle sizes of airborne radioactivities is essential for the estimation of internal doses. For that purpose, the study on radioactive airborne species formed in the air of beam-line tunnels at high-energy accelerators have been extensively conducted by our group. For Be-7, Na-24, S-38, Cl-38,-39, C-11, and N-13, formed by various types of nuclear reactions including nuclear spallation reactions, their aerosol and gaseous fractions are determined by a filter technique. A parallel plate diffusion battery is used for the measurement of aerosol size distributions, and the formation of radioactive aerosols is explained by the attachment of radionuclides to ambient non-radioactive aerosols which are formed through radiation induced reactions. The chemical forms of gaseous species are also determined by using a selective collection method based on a filter technique. A review is given of the physico-chemical properties of these airborne radionuclides produced in the air of accelerator beam-line tunnels.

Regional blood flow in the domestic fowl immediately following chronic acceleration

International Nuclear Information System (INIS)

Weidner, W.J.; Hoffman, L.F.; Clark, S.D.

1982-01-01

In order to examine the effects of chronic low G acceleration on blood flow distribution and cardiac output, chickens (N.10) were centrifuged at +2Gz for 30-61 d. Controls (N.12) were not centrifuged. The animals were anesthetized with sodium pentobarbital after removal from the centrifuge and surgically prepared in order to measure cardiac output and regional blood flows by the reference sample method with 85 Sr labeled microspheres (15 +/- 5 mum diam.). Both brachial arteries were cannulated to withdraw timed, paired blood samples at a known rate. The chest was opened and a cannula inserted into the left ventricle for administration of microspheres. Tissue samples were taken after completion of experimental procedures and their radioactivity was determined. The cardiac outputs in the two groups were not significantly different. Regional blood flows to the kidney, eyes, and skeletal muscle were significantly increased in the animals subjected to chronic +2Gz. While the mechanism by which these increases in blood flow occurred is not known, results indicate that chronic exposure to hyperdynamic gravitational fields can alter circulatory dynamics. We conclude that the cardiovascular system is directly involved in the process of adaptation to chronic positive acceleration

High-voltage terminal test of a test stand for a 1-MV electrostatic accelerator

Science.gov (United States)

Park, Sae-Hoon; Kim, Yu-Seok

2015-10-01

The Korea Multipurpose Accelerator Complex has been developing a 300-kV test stand for a 1-MV electrostatic accelerator ion source. The ion source and accelerating tube will be installed in a high-pressure vessel. The ion source in the high-pressure vessel is required to have a high reliability. The test stand has been proposed and developed to confirm the stable operating conditions of the ion source. The ion source will be tested at the test stand to verify the long-time operating conditions. The test stand comprises a 300-kV high-voltage terminal, a battery for the ion-source power, a 60-Hz inverter, 200-MHz radio-frequency power supply, a 5-kV extraction power supply, a 300-kV accelerating tube, and a vacuum system. The results of the 300-kV high-voltage terminal tests are presented in this paper.

High-speed hydrogen pellet acceleration using an electromagnetic railgun system

Energy Technology Data Exchange (ETDEWEB)

Onozuka, M.; Oda, Y. [Mitsubishi Heavy Ind., Ltd., Yokohama (Japan). Nucl. Fuel Cycle Eng. Dept.; Azuma, K.; Kasai, S.; Hasegawa, K. [Japan Atomic Energy Res. Inst., Tokai (Japan)

1997-07-01

Using a low electric energy railgun system, solid hydrogen pellet acceleration test have been conducted to investigate the application of the electromagnetic railgun system for high-speed pellet injection into fusion plasmas. Pneumatically pre-accelerated hydrogen pellets measuring 3 mm in diameter and 4-9 mm in length were successfully accelerated by a railgun system that uses a laser-induced plasma armature formation. A 2 m long single railgun with ceramic insulators accelerated th hydrogen pellet to 2.6 kms{sup -1} with a supplied energy of 1.7 kJ. The average acceleration rate and the energy conversion coefficient were improved to about 1.6 x 10{sup 6} ms{sup -2} and 0.37%, which is 1.6 times and three times as large as that using a railgun with plastic insulators, respectively. Furthermore, using the 1 m long augment railgun with ceramic insulators, the energy conversion coefficient was improved to about 0.55% while the acceleration rate was increased to 2.4 x 10{sup 6} ms{sup -2}. The highest hydrogen pellet velocity attained was about 2.3 kms{sup -1} for the augment railgun under an energy supply of 1.1 kJ. Based on the findings, it is expected that the acceleration efficiency and the pellet velocity can be further improved by using a longer augment railgun with ceramic insulators and by applying an optimal power supply. (orig.)

Ultrafast terawatt laser sources for high-field particle acceleration and short wavelength generation

International Nuclear Information System (INIS)

Downer, M.C.

1996-01-01

The Laser Sources working group concerned itself with recent advances in and future requirements for the development of laser sources relevant to high-energy physics (HEP) colliders, small scale accelerators, and the generation of short wave-length radiation. We heavily emphasized pulsed terawatt peak power laser sources for several reasons. First, their development over the past five years has been rapid and multi-faceted, and has made relativistic light intensity available to the advanced accelerator community, as well as the wider physics community, for the first time. Secondly, they have strongly impacted plasma-based accelerator research over the past two years, producing the first experimental demonstrations of the laser wakefield accelerator (LWFA) in both its resonantly-driven and self-modulated forms. Thirdly, their average power and wall-plug efficiency currently fall well short of projected requirements for future accelerators and other high average power applications, but show considerable promise for improving substantially over the next few years. A review of this rapidly emerging laser technology in the context of advanced accelerator research is therefore timely

Transport and acceleration of the high-current ion beam in magneto-isolated gap

International Nuclear Information System (INIS)

Karas', V.I.; Kornilov, E.A.; Manuilenko, O.V.; Fedorovskaya, O.V.; Tarakanov, V.P.

2015-01-01

The possibility of transportation and acceleration of the high-current ion beam in the magneto-isolated gap has been demonstrated. Found the parameters of the system and beams (the magnetic field produced by the coils with opposing currents, the size of the system, and the parameters of the beams), under which the uniform acceleration of the high-current ion beam all along the gap length is realized. It is shown that the quality of the ion beam, during transport and acceleration, at the exit of the gap is acceptable for many technological applications.

Status of spallation neutron source program in High Intensity Proton Accelerator Project

International Nuclear Information System (INIS)

Oyama, Yukio

2001-01-01

Japan Atomic Energy Research Institute and High Energy Accelerator Organization are jointly designing a 1 MW spallation neutron source as one of the research facilities planned in the High Intensity Proton Accelerator Project. The spallation neutron source is driven by 3 GeV proton beam with a mercury target and liquid hydrogen moderators. The present status of design for these spallation source and relevant facility is overviewed. (author)

The application analysis of high energy electron accelerator in food irradiation processing

International Nuclear Information System (INIS)

Deng Wenmin; Chen Hao; Feng Lei; Zhang Yaqun; Chen Xun; Li Wenjun; Xiang Chengfen; Pei Ying; Wang Zhidong

2012-01-01

Irradiation technology of high energy electron accelerator has been highly concerned in food processing industry with its fast development, especially in the field of food irradiation processing. In this paper, equipment and research situation of high energy electron accelerator were collected, meanwhile, the similarities and differences between high energy electron beam and 60 Co γ-rays were discussed. In order to provide more references of high energy electron beam irradiation, the usages of high energy electron in food irradiation processing was prospected. These information would promote the development of domestic food irradiation industry and give a useful message to irradiation enterprises and researchers. (authors)

Pulsed high field magnets. An efficient way of shaping laser accelerated proton beams for application

Energy Technology Data Exchange (ETDEWEB)

Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany); Technische Universitaet Dresden, 01062 Dresden (Germany); Bagnoud, Vincent; Blazevic, Abel; Busold, Simon [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Helmholtz Institut Jena, 07734 Jena (Germany); Brabetz, Christian; Schumacher, Dennis [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Deppert, Oliver; Jahn, Diana; Roth, Markus [Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Karsch, Leonhard; Masood, Umar [OncoRay-National Center for Radiation Research in Oncology, TU Dresden, 01307 Dresden (Germany); Kraft, Stephan [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany)

2015-07-01

Compact laser-driven proton accelerators are a potential alternative to complex, expensive conventional accelerators, enabling unique beam properties, like ultra-high pulse dose. Nevertheless, they still require substantial development in reliable beam generation and transport. We present experimental studies on capture, shape and transport of laser and conventionally accelerated protons via pulsed high-field magnets. These magnets, common research tools in the fields of solid state physics, have been adapted to meet the demands of laser acceleration experiments.Our work distinctively shows that pulsed magnet technology makes laser acceleration more suitable for application and can facilitate compact and efficient accelerators, e.g. for material research as well as medical and biological purposes.

Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement.

Science.gov (United States)

Sandoval, Yader; Smith, Stephen W; Shah, Anoop S V; Anand, Atul; Chapman, Andrew R; Love, Sara A; Schulz, Karen; Cao, Jing; Mills, Nicholas L; Apple, Fred S

2017-01-01

Rapid rule-out strategies using high-sensitivity cardiac troponin assays are largely supported by studies performed outside the US in selected cohorts of patients with chest pain that are atypical of US practice, and focused exclusively on ruling out acute myocardial infarction (AMI), rather than acute myocardial injury, which is more common and associated with a poor prognosis. Prospective, observational study of consecutive patients presenting to emergency departments [derivation (n = 1647) and validation (n = 2198) cohorts], where high-sensitivity cardiac troponin I (hs-cTnI) was measured on clinical indication. The negative predictive value (NPV) and diagnostic sensitivity of an hs-cTnI concentration rules out acute myocardial injury, regardless of etiology, with an excellent NPV and diagnostic sensitivity, and identifies patients at minimal risk of AMI or cardiac death at 30 days. ClinicalTrials.gov Identifier: NCT02060760. © 2016 American Association for Clinical Chemistry.

Conceptual study of high power proton linac for accelerator driven subcritical nuclear power system

International Nuclear Information System (INIS)

Yu Qingchang; Ouyang Huafu; Xu Taoguang

2002-01-01

As a prior option of the next generation of energy source, the accelerator driven subcritical nuclear power system (ADS) can use efficiently the uranium and thorium resource, transmute the high-level long-lived radioactive wastes and raise nuclear safety. The ADS accelerator should provide the proton beam with tens megawatts. The superconducting linac is a good selection of ADS accelerator because of its high efficiency and low beam loss rate. The ADS accelerator presented by the authors consists of a 5 MeV radio-frequency quadrupole, a 100 MeV independently phased superconducting cavity linac and a 1 GeV elliptical superconducting cavity linac. The accelerating structures and main parameters are determined and the research and development plan is considered

Open cell conducting foams for high synchrotron radiation accelerators

Directory of Open Access Journals (Sweden)

S. Petracca

2014-08-01

Full Text Available The possible use of open cell conductive foams in high synchrotron radiation particle accelerators is considered. Available materials and modeling tools are reviewed, potential pros and cons are discussed, and preliminary conclusions are drawn.

High power radiation guiding systems for laser driven accelerators

International Nuclear Information System (INIS)

Cutolo, A.

1985-01-01

This paper reviews the main problems encountered in the design of an optical system for transmitting high fluence radiation in a laser driven accelerator. Particular attention is devoted to the analysis of mirror and waveguide systems. (orig.)

Siberian Snakes in high-energy accelerators

International Nuclear Information System (INIS)

Mane, S R; Shatunov, Yu M; Yokoya, K

2005-01-01

We review modern techniques to accelerate spin-polarized beams to high energy and to preserve their polarization in storage rings. Crucial to the success of such work is the use of so-called Siberian Snakes. We explain these devices and the reason for their necessity. Closely related to Snakes is the concept of 'spin rotators'. The designs and merits of several types of Snakes and spin rotators are examined. Theoretical work with Snakes and spin rotators, and experimental results from several storage rings, are reviewed, including the so-called Snake resonances. (topical review)

High gradient accelerators for linear light sources

International Nuclear Information System (INIS)

Barletta, W.A.

1988-01-01

Ultra-high gradient radio frequency linacs powered by relativistic klystrons appear to be able to provide compact sources of radiation at XUV and soft x-ray wavelengths with a duration of 1 picosecond or less. This paper provides a tutorial review of the physics applicable to scaling the present experience of the accelerator community to the regime applicable to compact linear light sources. 22 refs., 11 figs., 21 tabs

High-current power supply for accelerator magnets

International Nuclear Information System (INIS)

Bourkland, K.R.; Winje, R.A.

1978-01-01

A power supply for controlling the current to accelerator magnets produces a high current at a precisely controlled time rate of change by varying the resonant frequency of an RLC circuit that includes the magnet and applying the current to the magnet during a predetermined portion of the waveform of an oscillation. The current is kept from going negative despite the reverse-current characteristics of thyristors by a quenching circuit

Beam manipulation techniques, nonlinear beam dynamics, and space charge effect in high energy high power accelerators

Energy Technology Data Exchange (ETDEWEB)

Lee, S. Y. [Indiana Univ., Bloomington, IN (United States)

2014-04-07

We had carried out a design of an ultimate storage ring with beam emittance less than 10 picometer for the feasibility of coherent light source at X-ray wavelength. The accelerator has an inherent small dynamic aperture. We study method to improve the dynamic aperture and collective instability for an ultimate storage ring. Beam measurement and accelerator modeling are an integral part of accelerator physics. We develop the independent component analysis (ICA) and the orbit response matrix method for improving accelerator reliability and performance. In collaboration with scientists in National Laboratories, we also carry out experimental and theoretical studies on beam dynamics. Our proposed research topics are relevant to nuclear and particle physics using high brightness particle and photon beams.

Concept for high-charge-state ion induction accelerators

International Nuclear Information System (INIS)

Logan, B.G.; Perry, M.D.; Caporaso, G.J.

1996-01-01

This work describes a particular concept for ion induction linac accelerators using high-charge-state ions produced by an intense, short pulse laser, and compares the costs of a modular driver system producing 6.5 MJ for a variety of ion masses and charge states using a simple but consistent cost model

Microwave superconductivity for particle accelerators - How the high TC superconductors measure up

International Nuclear Information System (INIS)

Padamsee, H.; Green, K.; Gruschus, J.

1988-01-01

Application of superconducting niobium cavities to accelerators for high energy physics, nuclear physics and free electron laser is growing rapidly. Cornell has a long standing effort in the development of superconducting RF accelerator technology. Nb cavities developed here from the basis for constructing the world's highest energy electron accelerator for nuclear physics. These cavities have set a standard against which the behavior of the new superconductors must be compared. From available results on dc critical fields, and the energy gap, it appears that the new materials could make a significant impact on the capabilities of future accelerators. Crucial to this assessment, however, are direct microwave loss measurements, together with measurements of the energy gap and RF frequency dependence as well as the behavior at high RF fields. Latest results on these properties for bulk sintered ceramics, thin films and single crystals at RF frequencies of 1.5 and 6 Ghz are presented

ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS

International Nuclear Information System (INIS)

Wei, J.; Macek, R.J.

2002-01-01

One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures

Trial of accelerator cells machining with high precision and high efficiency at Okayama region

International Nuclear Information System (INIS)

Yoshikawa, Mitsuo; Yoden, Hiroyuki; Yokomizo, Seiichi; Sumida, Tsuneto; Kunishida, Jun; Oshita, Isao

2005-01-01

In the framework of the project 'Promotion of Science and Technology in Regional Areas' by the Ministry of Education, Culture, Sports, Science and Technology, we have prepared a special apparatus for machining accelerator cells with a high precision and a high efficiency for the future linear collider. A machining with as small an error as 2 micrometers has been realized. Necessary time to finish one accelerator cell is reduced from 128 minutes to 34 minutes due to the suppression of the heating of the object at the machining. If newly developed one chuck method was employed, the precision and efficiency would be further improved. By cutting at both sides of the spindle, the necessary time for machining would be reduced by half. (author)

Comparison of high group velocity accelerating structures

International Nuclear Information System (INIS)

Farkas, Z.D.; Wilson, P.B.

1987-02-01

It is well known that waveguides with no perturbations have phase velocities greater than the velocity of light c. If the waveguide dimensions are chosen so that the phase velocity is only moderately greater than c, only small perturbations are required to reduce the phase velocity to be synchronous with a high energy particle bunch. Such a lightly loaded accelerator structure will have smaller longitudinal and transverse wake potentials and hence will lead to lower emittance growth in an accelerated beam. Since these structures are lightly loaded, their group velocities are only slightly less than c and not in the order of 0.01c, as is the case for the standard disk-loaded structures. To ascertain that the peak and average power requirements for these structures are not prohibitive, we examine the elastance and the Q for several traveling wave structures: phase slip structures, bellows-like structures, and lightly loaded disk-loaded structures

A conceptual design of the RF system for the NSP high intensity proton accelerator at JAERI

International Nuclear Information System (INIS)

Chishiro, Etsuji; Kusano, Joichi; Mizumoto, Motoharu; Touchi, Yutaka; Kaneko, Hiroshi; Takado, Hiroshi; Sawada, Junichi

1999-03-01

JAERI has been proposing the Neutron Science Project which aims at exploring the fields of basic science and nuclear technology using a high power spallation neutron source. The neutron source will be driven by a high intensity linear accelerator with an energy of 1.5 GeV and an average beam current of 5.33 mA and beam power of 8 MW. The RF system for the accelerator consists of a high-energy accelerator part and a low energy accelerator part. The maximum RF power requirements at the high and low energy accelerator parts are 25 MW and 8.3 MW, respectively. In this report, we describe the conceptual design of the RF system. In the low energy accelerator part, we estimated the requirement for the high-power amplifier tube and made the basis design for RF components. In the high energy accelerator part, we studied the effect of tuning errors, Lorentz forces and microphonics in the superconducting cavity. We calculated the klystron efficiency and supply power in the arrangement of where one klystron distributes the RF power to four cavities. We also considered an IOT RF system. Finally, we describe the electrical capacity and quantity of cooling water in the RF system. (author)

MHz repetition rate solid-state driver for high current induction accelerators

International Nuclear Information System (INIS)

Brooksby, C; Caporaso, G; Goerz, D; Hanks, R; Hickman, B; Kirbie, H; Lee, B; Saethre, R.

1999-01-01

A research team from the Lawrence Livermore National Laboratory and Bechtel Nevada Corporation is developing an all solid-state power source for high current induction accelerators. The original power system design, developed for heavy-ion fusion accelerators, is based on the simple idea of using an array of field effect transistors to switch energy from a pre-charged capacitor bank to an induction accelerator cell. Recently, that idea has been expanded to accommodate the greater power needs of a new class of high-current electron accelerators for advanced radiography. For this purpose, we developed a 3-stage induction adder that uses over 4,000 field effect transistors to switch peak voltages of 45 kV at currents up to 4.8 kA with pulse repetition rates of up to 2 MHz. This radically advanced power system can generate a burst of five or more pulses that vary from 200 ns to 2 ampersand micro;s at a duty cycle of up to 25%. Our new source is precise, robust, flexible, and exceeds all previous drivers for induction machines by a factor of 400 in repetition rate and a factor of 1000 in duty cycle

Laser-plasma accelerators, acceleration of particles through laser-matter interaction at ultra-high intensity

International Nuclear Information System (INIS)

Lefebvre, E.

2010-01-01

This series of slides overviews the development of powerful lasers for inertial confinement fusion (Icf) at NIF (National Ignition Facility, Usa) and LMJ (Laser Megajoule, France) facilities. Then the principle of laser wakefield acceleration is presented and the possibility of designing compact accelerators delivering 200 GeV/m while conventional RF accelerators reach only 50 MeV/m, is considered. This technical breakthrough will bring important gains in terms of size, cost and new uses for accelerators. While Icf will use nanosecond (10 -9 s) laser pulses, wakefield accelerators will use femtosecond (10 -15 s) laser pulses which means more power but less energy. The electrons accelerated by laser can produce a multi-MeV X radiation useful for industrial radiography or cancer treatment. (A.C.)

Educational program in crisis management for cardiac surgery teams including high realism simulation.

Science.gov (United States)

Stevens, Louis-Mathieu; Cooper, Jeffrey B; Raemer, Daniel B; Schneider, Robert C; Frankel, Allan S; Berry, William R; Agnihotri, Arvind K

2012-07-01

Cardiac surgery demands effective teamwork for safe, high-quality care. The objective of this pilot study was to develop a comprehensive program to sharpen performance of experienced cardiac surgical teams in acute crisis management. We developed and implemented an educational program for cardiac surgery based on high realism acute crisis simulation scenarios and interactive whole-unit workshop. The impact of these interventions was assessed with postintervention questionnaires, preintervention and 6-month postintervention surveys, and structured interviews. The realism of the acute crisis simulation scenarios gradually improved; most participants rated both the simulation and whole-unit workshop as very good or excellent. Repeat simulation training was recommended every 6 to 12 months by 82% of the participants. Participants of the interactive workshop identified 2 areas of highest priority: encouraging speaking up about critical information and interprofessional information sharing. They also stressed the importance of briefings, early communication of surgical plan, knowing members of the team, and continued simulation for practice. The pre/post survey response rates were 70% (55/79) and 66% (52/79), respectively. The concept of working as a team improved between surveys (P = .028), with a trend for improvement in gaining common understanding of the plan before a procedure (P = .075) and appropriate resolution of disagreements (P = .092). Interviewees reported that the training had a positive effect on their personal behaviors and patient care, including speaking up more readily and communicating more clearly. Comprehensive team training using simulation and a whole-unit interactive workshop can be successfully deployed for experienced cardiac surgery teams with demonstrable benefits in participant's perception of team performance. Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Cardiac pacemaker

International Nuclear Information System (INIS)

Kolenik, S.A.

1976-01-01

The construction of a cardiac pacemaker is described which is characterized by particularly small dimensions, small weight and long life duration. The weight is under 100g, the specific weight under 1.7. Mass inertia forces which occur through acceleration and retardation processes, thus remain below the threshold values, above which one would have to reckon with considerable damaging of the surrounding body tissue. The maintaining of small size and slight weight is achieved by using an oscillator on COSMOS basis, where by considerably lower energy consumption, amongst others the lifetimes of the batteries used - a lithium anode with thionyl chloride electrolyte - is extended to over 5 years. The reliability can be increased by the use of 2 or more batteries. The designed dimension are 20x60x60 mm 3 . (ORU/LH) [de

Surfing and drift acceleration at high mach number quasi-perpendicular shocks

International Nuclear Information System (INIS)

Amano, T.

2008-01-01

Electron acceleration in high Mach number collisionless shocks relevant to supernova remnant is discussed. By performing one- and two-dimensional particle-in-cell simulations of quasi-perpendicular shocks, we find that energetic electrons are quickly generated in the shock transition region through shock surfing and drift acceleration. The electron energization is strong enough to account for the observed injection at supernova remnant shocks. (author)

Ultra-high gradient compact accelerator developments

NARCIS (Netherlands)

Brussaard, G.J.H.; Wiel, van der M.J.

2004-01-01

Continued development of relatively compact, although not quite 'table-top', lasers with peak powers in the range up to 100 TW has enabled laser-plasma-based acceleration experiments with amazing gradients of up to 1 TV/m. In order to usefully apply such gradients to 'controlled' acceleration,

Super High Energy Colliding Beam Accelerators

International Nuclear Information System (INIS)

Abdelaziz, M.E.

2009-01-01

This lecture presents a review of cyclic accelerators and their energy limitations. A description is given of the phase stability principle and evolution of the synchrotron, an accelerator without energy limitation. Then the concept of colliding beams emerged to yield doubling of the beam energy as in the Tevatron 2 trillion electron volts (TeV) proton collider at Fermilab and the Large Hadron Collider (LHC) which is now planned as a 14-TeV machine in the 27 kilometer tunnel of the Large Electron Positron (LEP) collider at CERN. Then presentation is given of the Superconducting Supercollider (SSC), a giant accelerator complex with energy 40-TeV in a tunnel 87 kilometers in circumference under the country surrounding Waxahachie in Texas, U.S.A. These superhigh energy accelerators are intended to smash protons against protons at energy sufficient to reveal the nature of matter and to consolidate the prevailing general theory of elementary particle.

Modeling high-Power Accelerators Reliability-SNS LINAC (SNS-ORNL); MAX LINAC (MYRRHA)

International Nuclear Information System (INIS)

Pitigoi, A. E.; Fernandez Ramos, P.

2013-01-01

Improving reliability has recently become a very important objective in the field of particle accelerators. The particle accelerators in operation are constantly undergoing modifications, and improvements are implemented using new technologies, more reliable components or redundant schemes (to obtain more reliability, strength, more power, etc.) A reliability model of SNS (Spallation Neutron Source) LINAC has been developed within MAX project and analysis of the accelerator systems reliability has been performed within the MAX project, using the Risk Spectrum reliability analysis software. The analysis results have been evaluated by comparison with the SNS operational data. Results and conclusions are presented in this paper, oriented to identify design weaknesses and provide recommendations for improving reliability of MYRRHA linear accelerator. The SNS reliability model developed for the MAX preliminary design phase indicates possible avenues for further investigation that could be needed to improve the reliability of the high-power accelerators, in view of the future reliability targets of ADS accelerators.

Application of high power modulated intense relativistic electron beams for development of Wake Field Accelerator

International Nuclear Information System (INIS)

Friedman, M.

1989-01-01

This final Progress Report addresses DOE-sponsored research on the development of future high-gradient particle accelerators. The experimental and the theoretical research, which lasted three years, investigated the Two Beam Accelerator (TBA). This high-voltage-gradient accelerator was powered by a modulated intense relativistic electron beam (MIREB) of power >10 10 watts. This research was conceived after a series of successful experiments performed at NRL generating and using MIREBs. This work showed that an RF structure could be built which was directly powered by a modulated intense relativistic electron beam. This structure was then used to accelerate a second electron beam. At the end of the three year project the proof-of-principle accelerator demonstrated the generation of a high current beam of electrons with energy >60 MeV. Scaling laws needed to design practical devices for future applications were also derived

Optical design for increased interaction length in a high gradient dielectric laser accelerator

OpenAIRE

Cesar, D.; Maxson, J.; Musumeci, P.; Shen, X.; England, R. J.; Wootton, K. P.

2018-01-01

We present a methodology for designing and measuring pulse front tilt in an ultrafast laser for use in dielectric laser acceleration. Previous research into dielectric laser accelerating modules has focused on measuring high accelerating gradients in novel structures, but has done so only for short electron-laser coupling lengths. Here we demonstrate an optical design to extend the laser-electron interaction to 1mm.

Distributed coupling high efficiency linear accelerator

Science.gov (United States)

Tantawi, Sami G.; Neilson, Jeffrey

2016-07-19

A microwave circuit for a linear accelerator includes multiple monolithic metallic cell plates stacked upon each other so that the beam axis passes vertically through a central acceleration cavity of each plate. Each plate has a directional coupler with coupling arms. A first coupling slot couples the directional coupler to an adjacent directional coupler of an adjacent cell plate, and a second coupling slot couples the directional coupler to the central acceleration cavity. Each directional coupler also has an iris protrusion spaced from corners joining the arms, a convex rounded corner at a first corner joining the arms, and a corner protrusion at a second corner joining the arms.

Ultra-high vacuum technology for accelerators

CERN Multimedia

CERN. Geneva. Audiovisual Unit; Hilleret, Noël; Strubin, Pierre M

2002-01-01

The lectures will start with a review of the basics of vacuum physics required to build Ultra High Vacuum (UHV) systems, such as static and dynamic outgassing. Before reviewing the various pumping and measurement devices, including the most modern one like Non Evaporable Getter (NEG) coatings, an overview of adequate materials to be used in UHV systems will be given together with their treatment (e.g. cleaning procedures and bake out). Practical examples based on existing or future accelerators will be used to illustrate the topics. Finally, a short overview of modern vacuum controls and interlocks will be given.

Compact high-current, subnanosecond electron accelerator

Energy Technology Data Exchange (ETDEWEB)

Shpak, V G; Shunajlov, S A; Ulmaskulov, M R; Yalandin, M I [Russian Academy of Sciences, Ekaterinburg (Russian Federation). Inst. of Electrophysics; Pegel, I V [Russian Academy of Sciences, Tomsk (Russian Federation). High-Current Electronics Inst.; Tarakanov, V P [Russian Academy of Sciences, Moscow (Russian Federation). High-Temperature Inst.

1997-12-31

A compact subnanosecond, high-current electron accelerator producing an annular electron beam of duration up to 300 - 400 ps, energy about 250 keV, and current up to 1 kA has been developed to study transient processes in pulsed power microwave devices. The measuring and recording techniques used to experimentally investigate the dynamics of the beam current pulse and the transformation of the electron energy during the transportation of the beam in a longitudinal magnetic field are described. The experimental data obtained are compared with the predictions of a numerical simulation. (author). 6 figs., 5 refs.

Neutron dose measurements with the GSI ball at high energy accelerators

International Nuclear Information System (INIS)

Fehrenbacher, G.; Gutermuth, F.; Radon, T.; Kozlova, E.

2005-01-01

Full text: At high energy particle accelerators the production of neutron radiation dominates radiation protection. For the radiation survey at accelerators there is a need for reliable detection systems (passive radiation monitors), which can measure the dose for a wide range of neutron energies independently on the beam pulse structure of the produced radiation. In this work a passive neutron dosemeter for the measurement of the ambient dose equivalent is presented. The dosemeter is suitable for measurements of the emerging neutron radiation at accelerators for the whole energy range up to about 10 GeV. The dosemeter consists of a polyethylene sphere, TL elements (pairs of TLD600/700) and an additional lead layer (PE/Pb) in neutron fields at high energy accelerators is investigated in this work. Results of dose measurements which were performed in realistic neutron fields at the high energy accelerator SPS at CERN (CERF facility) and in Cave A at the heavy ion synchrotron SIS at GSI are presented. The results of these measurements are compared with the expected dose values from the neutron spectra determined for the measurement positions at CERF and in Cave A (FLUKA) and with the dosemeter response derived by the calculated response functions (FLUKA) folded with the neutron spectra. The comparisons show that the additional lead layer in the PE/Pb-sphere improves significantly the response of the dosemeter. The response of the PE/Pb-sphere is 40 to 50 % higher at CERF and Cave A in comparison to the bare PE-sphere. At CERF the dose values of the PE/Pb-sphere is about 25 % lower than the expected dose value, whilst for Cave A, a rather good agreement was found (2 % deviation). (author)

SOLVING BY PARALLEL COMPUTATION THE POISSON PROBLEM FOR HIGH INTENSITY BEAMS IN CIRCULAR ACCELERATORS

International Nuclear Information System (INIS)

LUCCIO, A.U.; DIMPERIO, N.L.; SAMULYAK, R.; BEEB-WANG, J.

2001-01-01

Simulation of high intensity accelerators leads to the solution of the Poisson Equation, to calculate space charge forces in the presence of acceleration chamber walls. We reduced the problem to ''two-and-a-half'' dimensions for long particle bunches, characteristic of large circular accelerators, and applied the results to the tracking code Orbit

Cardiac CT

International Nuclear Information System (INIS)

Dewey, Marc

2011-01-01

Computed tomography of the heart has become a highly accurate diagnostic modality that is attracting increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues to be discussed are coronary artery bypass grafts, stents, plaques, and anomalies, cardiac valves, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as plaque imaging and functional assessment, are also explored. (orig.)

Cardiac CT

Energy Technology Data Exchange (ETDEWEB)

Dewey, Marc [Charite - Universitaetsmedizin Berlin (Germany). Inst. fuer Radiologie

2011-07-01

Computed tomography of the heart has become a highly accurate diagnostic modality that is attracting increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues to be discussed are coronary artery bypass grafts, stents, plaques, and anomalies, cardiac valves, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as plaque imaging and functional assessment, are also explored. (orig.)

Proton and Ion Sources for High Intensity Accelerators

CERN Multimedia

Scrivens, R

2004-01-01

Future high intensity ion accelerators, including the Spallation Neutron Source (SNS), the European Spallation Source (ESS), the Superconducting Proton Linac (SPL) etc, will require high current and high duty factor sources for protons and negative hydrogen ions. In order to achieve these goals, a comparison of the Electron Cyclotron Resonance, radio-frequency and Penning ion sources, among others, will be made. For each of these source types, the present operational sources will be compared to the state-of-the-art research devices with special attention given to reliability and availability. Finally, the future research and development aims will be discussed.

ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS.

Energy Technology Data Exchange (ETDEWEB)

WEI,J.; MACEK,R.J.

2002-04-14

One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures.

High-brightness negative-hydrogen linear accelerator

International Nuclear Information System (INIS)

Wadlinger, E.A.; Farrell, J.A.; Dogliani, H.O.

1982-01-01

We have designed a linear accelerator to accelerate negative hydrogen ions to 50 MeV with an instantaneous output current of 100 mA and a normalized rms emittance in both transverse planes of 0.02 π cm mrad. The design and results obtained to date with a 2-MeV prototype are presented

Design and Optimization of Large Accelerator Systems through High-Fidelity Electromagnetic Simulations

International Nuclear Information System (INIS)

Ng, Cho; Akcelik, Volkan; Candel, Arno; Chen, Sheng; Ge, Lixin; Kabel, Andreas; Lee, Lie-Quan; Li, Zenghai; Prudencio, Ernesto; Schussman, Greg; Uplenchwar1, Ravi; Xiao1, Liling; Ko1, Kwok; Austin, T.; Cary, J.R.; Ovtchinnikov, S.; Smith, D.N.; Werner, G.R.; Bellantoni, L.; TechX Corp.; Fermilab

2008-01-01

SciDAC1, with its support for the 'Advanced Computing for 21st Century Accelerator Science and Technology' (AST) project, witnessed dramatic advances in electromagnetic (EM) simulations for the design and optimization of important accelerators across the Office of Science. In SciDAC2, EM simulations continue to play an important role in the 'Community Petascale Project for Accelerator Science and Simulation' (ComPASS), through close collaborations with SciDAC CETs/Institutes in computational science. Existing codes will be improved and new multi-physics tools will be developed to model large accelerator systems with unprecedented realism and high accuracy using computing resources at petascale. These tools aim at targeting the most challenging problems facing the ComPASS project. Supported by advances in computational science research, they have been successfully applied to the International Linear Collider (ILC) and the Large Hadron Collider (LHC) in High Energy Physics (HEP), the JLab 12-GeV Upgrade in Nuclear Physics (NP), as well as the Spallation Neutron Source (SNS) and the Linac Coherent Light Source (LCLS) in Basic Energy Sciences (BES)

Design and optimization of large accelerator systems through high-fidelity electromagnetic simulations

International Nuclear Information System (INIS)

Ng, C; Akcelik, V; Candel, A; Chen, S; Ge, L; Kabel, A; Lee, Lie-Quan; Li, Z; Prudencio, E; Schussman, G; Uplenchwar, R; Xiao, L; Ko, K; Austin, T; Cary, J R; Ovtchinnikov, S; Smith, D N; Werner, G R; Bellantoni, L

2008-01-01

SciDAC-1, with its support for the 'Advanced Computing for 21st Century Accelerator Science and Technology' project, witnessed dramatic advances in electromagnetic (EM) simulations for the design and optimization of important accelerators across the Office of Science. In SciDAC2, EM simulations continue to play an important role in the 'Community Petascale Project for Accelerator Science and Simulation' (ComPASS), through close collaborations with SciDAC Centers and Insitutes in computational science. Existing codes will be improved and new multi-physics tools will be developed to model large accelerator systems with unprecedented realism and high accuracy using computing resources at petascale. These tools aim at targeting the most challenging problems facing the ComPASS project. Supported by advances in computational science research, they have been successfully applied to the International Linear Collider and the Large Hadron Collider in high energy physics, the JLab 12-GeV Upgrade in nuclear physics, and the Spallation Neutron Source and the Linac Coherent Light Source in basic energy sciences

Special scientific programme on use of high energy accelerators for transmutation of actinides and power production

International Nuclear Information System (INIS)

1994-09-01

Various techniques for the transmutation of radioactive waste through the use of high energy accelerators are reviewed and discussed. In particular, the present publication contains presentations on (i) requirements and the technical possibilities for the transmutation of long-lived radionuclides (background paper); (ii) high energy particle accelerators for bulk transformation of elements and energy generation; (iii) the resolution of nuclear energy issues using accelerator-driven technology; (iv) the use of proton accelerators for the transmutation of actinides and power production; (v) the coupling of an accelerator to a subcritical fission reactor (with a view on its potential impact on waste transmutation); (vi) research and development of accelerator-based transmutation technology at JAERI (Japan); and (vii) questions and problems with regard to accelerator-driven nuclear power and transmutation facilities. Refs, figs and tabs

Application of magnetically insulated transmission lines for high current, high voltage electron beam accelerators

International Nuclear Information System (INIS)

Shope, S.L.; Mazarakis, M.G.; Frost, C.A.; Poukey, J.W.; Turman, B.N.

1993-01-01

Self Magnetically Insulated Transmission Lines (MITL) adders have been used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently the authors used a MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r b < 2 cm), 11 to 15 MeV, 50 to 100-kA beams with a small transverse velocity v perpendicular/c = β perpendicular ≤ 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. The authors' success with the MITL technology led them to investigate the application to higher energy accelerator designs. They have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30-50-ns FWHM output pulse

Application of Magnetically Insulated Transmission Lines for high current, high voltage electron beam accelerators

International Nuclear Information System (INIS)

Shope, S.L.; Mazarakis, M.G.; Frost, C.A.; Poukey, J.W.; Turman, B.N.

1991-01-01

Self Magnetically Insulated Transmission Lines (MITL) adders have been used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently we used at MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r ρ < 2 cm), 11 to 15 MeV, 50 to 100-kA beams with a small transverse velocity v perpendicular/c = β perpendicular ≤ 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. Our success with the MITL technology led us to investigate the application to higher energy accelerator designs. We have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30--50 ns FWHM output pulse. 10 refs

Application of magnetically insulated transmission lines for high current, high voltage electron beam accelerators

Science.gov (United States)

Shope, S. L.; Mazarakis, M. G.; Frost, C. A.; Poukey, J. W.; Turman, B. N.

Self Magnetically Insulated Transmission Lines (MITL) adders were used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently we used at MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r(sub rho) less than 2 cm), 11 - 15 MeV, 50 - 100-kA beams with a small transverse velocity v(perpendicular)/c = beta(perpendicular) less than or equal to 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. Our success with the MITL technology led us to investigate the application to higher energy accelerator designs. We have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30 - 50 ns FWHM output pulse.

A high current, short pulse electron source for wakefield accelerators

International Nuclear Information System (INIS)

Ho, Ching-Hung.

1992-01-01

Design studies for the generation of a high current, short pulse electron source for the Argonne Wakefield Accelerator are presented. An L-band laser photocathode rf gun cavity is designed using the computer code URMEL to maximize the electric field on the cathode surface for fixed frequency and rf input power. A new technique using a curved incoming laser wavefront to minimize the space charge effect near the photocathode is studied. A preaccelerator with large iris to minimize wakefield effects is used to boost the drive beam to a useful energy of around 20 MeV for wakefield acceleration experiments. Focusing in the photocathode gun and the preaccelerator is accomplished with solenoids. Beam dynamics simulations throughout the preaccelerator are performed using particle simulation codes TBCI-SF and PARMELA. An example providing a useful set of operation parameters for the Argonne Wakefield Accelerator is given. The effects of the sagitta of the curved beam and laser amplitude and timing jitter effects are discussed. Measurement results of low rf power level bench tests and a high power test for the gun cavity are presented and discussed

Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol

NARCIS (Netherlands)

Than, Martin; Flaws, Dylan; Sanders, Sharon; Doust, Jenny; Glasziou, Paul; Kline, Jeffery; Aldous, Sally; Troughton, Richard; Reid, Christopher; Parsonage, William A.; Frampton, Christopher; Greenslade, Jaimi H.; Deely, Joanne M.; Hess, Erik; Sadiq, Amr Bin; Singleton, Rose; Shopland, Rosie; Vercoe, Laura; Woolhouse-Williams, Morgana; Ardagh, Michael; Bossuyt, Patrick; Bannister, Laura; Cullen, Louise

2014-01-01

Risk scores and accelerated diagnostic protocols can identify chest pain patients with low risk of major adverse cardiac event who could be discharged early from the ED, saving time and costs. We aimed to derive and validate a chest pain score and accelerated diagnostic protocol (ADP) that could

Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression.

Science.gov (United States)

Jiang, Yong; Wang, Hui-Yan; Zheng, Sheng; Mu, Shang-Qiang; Ma, Meng-Ni; Xie, Xin; Zhang, Yang-Yang; Zhang, Chun-Xue; Cai, Jian-Hui

2015-01-01

Hypertension is the most common risk factor for various cardiovascular and cerebrovascular diseases that affects approximately 61 million, or 25% of the population in United States. The dietary salt intake is one of the most important but modifiable factors for hypertension. In the current study, we aim to elucidate the role of aquaporin 1 in high-salt-induced hypertension and cardiac injuries and whether angiotensin II receptor blocker valsartan could ameliorate the effect of high salt on blood pressure. Mice were fed with normal diet, high-salt diet in the presence or absence of valsartan for 4 weeks. The body weight gain, feeding behavior, blood pressure, and cardiac pathology changes were monitored after 4 weeks. The expression of aquaporin 1, vascular endothelial growth factor, transforming growth factor β1, and basic fibroblast growth factor were analyzed using quantitative real-time polymerase chain reaction, Western blot, and immunohistochemical staining. Valsartan partially reversed the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone did not exert such effects. The current data demonstrated that the reduction of cardiac aquaporin 1 and angiogenic factor expression level might be associated with high-salt-induced hypertension and cardiac injuries in mice, which could be ameliorated by angiotensin II receptor blocker treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion.

Science.gov (United States)

Bai, Wenjia; Shi, Wenzhe; de Marvao, Antonio; Dawes, Timothy J W; O'Regan, Declan P; Cook, Stuart A; Rueckert, Daniel

2015-12-01

Atlases encode valuable anatomical and functional information from a population. In this work, a bi-ventricular cardiac atlas was built from a unique data set, which consists of high resolution cardiac MR images of 1000+ normal subjects. Based on the atlas, statistical methods were used to study the variation of cardiac shapes and the distribution of cardiac motion across the spatio-temporal domain. We have shown how statistical parametric mapping (SPM) can be combined with a general linear model to study the impact of gender and age on regional myocardial wall thickness. Finally, we have also investigated the influence of the population size on atlas construction and atlas-based analysis. The high resolution atlas, the statistical models and the SPM method will benefit more studies on cardiac anatomy and function analysis in the future. Copyright © 2015 Elsevier B.V. All rights reserved.

Application of High Temperature Superconductors to Accelerators

CERN Document Server

Ballarino, A

2000-01-01

Since the discovery of high temperature superconductivity, a large effort has been made by the scientific community to investigate this field towards a possible application of the new oxide superconductors to different devices like SMES, magnetic bearings, flywheels energy storage, magnetic shielding, transmission cables, fault current limiters, etc. However, all present day large scale applications using superconductivity in accelerator technology are based on conventional materials operating at liquid helium temperatures. Poor mechanical properties, low critical current density and sensitivity to the magnetic field at high temperature are the key parameters whose improvement is essential for a large scale application of high temperature superconductors to such devices. Current leads, used for transferring currents from the power converters, working at room temperature, into the liquid helium environment, where the magnets are operating, represent an immediate application of the emerging technology of high t...

High-resolution accelerator alignment using x-ray optics

Directory of Open Access Journals (Sweden)

Bingxin Yang

2006-03-01

Full Text Available We propose a novel alignment technique utilizing the x-ray beam of an undulator in conjunction with pinholes and position-sensitive detectors for positioning components of the accelerator, undulator, and beam line in an x-ray free-electron laser. Two retractable pinholes at each end of the undulator define a stable and reproducible x-ray beam axis (XBA. Targets are precisely positioned on the XBA using a pinhole camera technique. Position-sensitive detectors responding to both x-ray and electron beams enable direct transfer of the position setting from the XBA to the electron beam. This system has the potential to deliver superior alignment accuracy (1–3   μm for target pinholes in the transverse directions over a long distance (200 m or longer. It can be used to define the beam axis of the electron-beam–based alignment, enabling high reproducibility of the latter. This x-ray–based concept should complement the electron-beam–based alignment and the existing survey methods to raise the alignment accuracy of long accelerators to an unprecedented level. Further improvement of the transverse accuracy using x-ray zone plates will be discussed. We also propose a concurrent measurement scheme during accelerator operation to allow real-time feedback for transverse position correction.

SRAM-Based Passive Dosimeter for High-Energy Accelerator Environments

CERN Document Server

Makowski, D R; Napieralski, A; Swiercz, B P

2005-01-01

This paper reports a novel NVRAM-based neutron dose monitor (REM counter). The principle of this device is based on the radiation effect initiating the Single Event Upset SEU in high density microelectronic memories. Several batches of Non-Volatile memories from different manufactures were examined in various radiation environments, i.e. 241Am-Be (alpha,n) and Linear accelerators produced radiation fields. A suitable moderator was used to enhance the detector sensitivity. Further experiments were carried out in Linear Accelerators: Linac II, TTF2 and Beam Loss Environment of various Experimental Facilities at DESY Research Centre in Hamburg. A separate batch of SRAM was irradiated with 60Co-gamma rays up to a dose of about 60 Gy. No Single Event Upset (SEU) was registered. This validates, that gamma radiation has a negligible effect to trigger SEU in the SRAM. The proposed detector could be ideal for a neutron dose measurement produced by a high-energy electron linac, including synchrotron and Free Electron L...

High gradient tests of SLAC Linear Collider Accelerator Structures

International Nuclear Information System (INIS)

Wang, J.W.; Deruyter, H.; Eichner, J.; Fant, K.H.; Hoag, H.A.; Koontz, R.F.; Lavine, T.; Loew, G.A.; Loewen, R.; Menegat, L.

1994-08-01

This paper describes the current SLAC R ampersand D program to develop room temperature accelerator structures for the Next Linear Collider (NLC). The structures are designed to operate at 11.4 GHz at an accelerating gradient in the range of 50 to 100 MV/m. In the past year a 26 cm constant-impedance traveling-wave section, a 75 cm constant-impedance traveling-wave section, and a 1.8 m traveling-wave section with detuned deflecting modes have been high-power tested. The paper presents a brief description of the RF test setup, the design and manufacturing details of the structures, and a discussion of test results including field emission, RF processing, dark current spectrum and RF breakdown

Transport of accelerator produced high energy neutrons though concrete

International Nuclear Information System (INIS)

Prabhakar Rao, G.; Sarkar, P.K.

1996-01-01

Development of a computational system for estimating the production and transport of high energy neutrons in particle accelerators is reported. The energy-angle distribution of neutrons from accelerated ions bombarding thick targets is calculated by a hybrid nuclear reaction model code, ALICE-91, modified to suit the purpose. Subsequent transmission of these neutrons through concrete slabs is treated using the anisotropic source-flux iteration technique (ASFIT) in the framework of a coupled neutron-gamma transport. Several parameters of both the codes have been optimized to obtain the transmitted dose through concrete. The calculations are found to be accurate and at the same time faster compared to the detailed Monte Carlo calculations. (author). 8 refs., 2 figs

Cardiac arrest

Science.gov (United States)

... magnesium. These minerals help your heart's electrical system work. Abnormally high or low levels can cause cardiac arrest. Severe physical stress. Anything that causes a severe stress on your ...

Design and construction of tetrode tube modulator for high power electron accelerator

Directory of Open Access Journals (Sweden)

A M Poursaleh

2015-09-01

Full Text Available In this paper, a high power tetrode tube (TH781-200kW, cw modulator is designed and implemented. This modulator is used for a part of RF system of the first Iranian high power electron accelerator project with similar structure to Rhodotron accelerator. Regarding to the level of sensitive and importance of TH781 tube the modulator system designed with high accuracy. So beside of power supplies design the control circuits for protection of the tube have been considered. The results of test and operation of this system that have been constructed in Iran for fist time is very satisfactory

Biosynthesis of cardiac natriuretic peptides

DEFF Research Database (Denmark)

Goetze, Jens Peter

2010-01-01

Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac...... peptides has only been elucidated during the last decade. The cellular synthesis including amino acid modifications and proteolytic cleavages has proven considerably more complex than initially perceived. Consequently, the elimination phase of the peptide products in circulation is not yet well....... An inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...

High efficiency RF amplifier development over wide dynamic range for accelerator application

Science.gov (United States)

Mishra, Jitendra Kumar; Ramarao, B. V.; Pande, Manjiri M.; Joshi, Gopal; Sharma, Archana; Singh, Pitamber

2017-10-01

Superconducting (SC) cavities in an accelerating section are designed to have the same geometrical velocity factor (βg). For these cavities, Radio Frequency (RF) power needed to accelerate charged particles varies with the particle velocity factor (β). RF power requirement from one cavity to other can vary by 2-5 dB within the accelerating section depending on the energy gain in the cavity and beam current. In this paper, we have presented an idea to improve operating efficiency of the SC RF accelerators using envelope tracking technique. A study on envelope tracking technique without feedback is carried out on a 1 kW, 325 MHz, class B (conduction angle of 180 degrees) tuned load power amplifier (PA). We have derived expressions for the efficiency and power output for tuned load amplifier operating on the envelope tracking technique. From the derived expressions, it is observed that under constant load resistance to the device (MOSFET), optimum amplifier efficiency is invariant whereas output power varies with the square of drain bias voltage. Experimental results on 1 kW PA module show that its optimum efficiency is always greater than 62% with variation less than 5% from mean value over 7 dB dynamic range. Low power amplifier modules are the basic building block for the high power amplifiers. Therefore, results for 1 kW PA modules remain valid for the high power solid state amplifiers built using these PA modules. The SC RF accelerators using these constant efficiency power amplifiers can improve overall accelerator efficiency.

Study of the power supply topology with high stability for accelerator

International Nuclear Information System (INIS)

Wu Wei; Wang Yunfang; Wang Jiewei

2005-01-01

The requirements of the power supply for accelerator are analyzed. A few of topologies of the highly stabilized power supply are discussed. The types are listed: Auto-transformers-diode rectifier-transistor regulating current. Thyristor rectifier regulating voltage -transistor regulating current, Diode rectifier -DC-chopping. Thyristor rectifier regulating voltage -two-quadrant-chopping. The advantages and disadvantages of the topologies for power supply are discussed. The notice questions of the power supply designed for accelerator are analyzed. (authors)

High performance proton accelerators

International Nuclear Information System (INIS)

Favale, A.J.

1989-01-01

In concert with this theme this paper briefly outlines how Grumman, over the past 4 years, has evolved from a company that designed and fabricated a Radio Frequency Quadrupole (RFQ) accelerator from the Los Alamos National Laboratory (LANL) physics and specifications to a company who, as prime contractor, is designing, fabricating, assembling and commissioning the US Army Strategic Defense Commands (USA SDC) Continuous Wave Deuterium Demonstrator (CWDD) accelerator as a turn-key operation. In the case of the RFQ, LANL scientists performed the physics analysis, established the specifications supported Grumman on the mechanical design, conducted the RFQ tuning and tested the RFQ at their laboratory. For the CWDD Program Grumman has the responsibility for the physics and engineering designs, assembly, testing and commissioning albeit with the support of consultants from LANL, Lawrence Berkeley Laboratory (LBL) and Brookhaven National laboratory. In addition, Culham Laboratory and LANL are team members on CWDD. LANL scientists have reviewed the physics design as well as a USA SDC review board. 9 figs

Electron beam welding of high-purity copper accelerator cells

International Nuclear Information System (INIS)

Delis, K.; Haas, H.; Schlebusch, P.; Sigismund, E.

1986-01-01

The operating conditions of accelerator cells require high thermal conductivity, low gas release in the ultrahigh vacuum, low content of low-melting metals and an extremely good surface quality. In order to meet these requirements, high-purity copper (OFHC, Grade 1, according to ASTM B 170-82 and extra specifications) is used as structural material. The prefabricated components of the accelerator cells (noses, jackets, flanges) are joined by electron beam welding, the weld seam being assessed on the basis of the same criteria as the base material. The welding procedures required depend, first, on the material and, secondly, on the geometries involved. Therefore experimental welds were made first on standardized specimens in order to study the behaviour of the material during electron beam welding and the influence of parameter variations. The welded joints of the cell design were planned on the basis of these results. Seam configuration, welding procedures and the parameters were optimized on components of original geometry. The experiments have shown that high-quality joints of this grade of copper can be produced by the electron beam welding process, if careful planning and preparation of the seams and adequate containment of the welding pool are assured. (orig.)

Teaching Electromagnetism to High-School Students Using Particle Accelerators

Science.gov (United States)

Sinflorio, D. A.; Fonseca, P.; Coelho, L. F. S.; Santos, A. C. F.

2006-01-01

In this article we describe two simple experiments using an ion accelerator as an aid to the teaching of electromagnetism to high-school students. This is part of a programme developed by a Brazilian State funding agency (FAPERJ) which aims to help scientifically minded students take their first steps in research.

The neutron dose equivalent around high energy medical electron linear accelerators

Directory of Open Access Journals (Sweden)

Poje Marina

2014-01-01

Full Text Available The measurement of neutron dose equivalent was made in four dual energy linear accelerator rooms. Two of the rooms were reconstructed after decommissioning of 60Co units, so the main limitation was the space. The measurements were performed by a nuclear track etched detectors LR-115 associated with the converter (radiator that consist of 10B and with the active neutron detector Thermo BIOREM FHT 742. The detectors were set at several locations to evaluate the neutron ambient dose equivalent and/or neutron dose rate to which medical personnel could be exposed. Also, the neutron dose dependence on collimator aperture was analyzed. The obtained neutron dose rates outside the accelerator rooms were several times smaller than the neutron dose rates inside the accelerator rooms. Nevertheless, the measured neutron dose equivalent was not negligible from the aspect of the personal dosimetry with almost 2 mSv a year per person in the areas occupied by staff (conservative estimation. In rooms with 15 MV accelerators, the neutron exposure to the personnel was significantly lower than in the rooms having 18 MV accelerators installed. It was even more pronounced in the room reconstructed after the 60Co decommissioning. This study confirms that shielding from the neutron radiation should be considered when building vaults for high energy linear accelerators, especially when the space constraints exist.

2014 Joint International Accelerator School: Beam Loss and Accelerator Protection

CERN Document Server

JAS - Joint US-CERN-Japan-Russia Accelerator School

2016-01-01

Many particle accelerators operate with very high beam power and very high energy stored in particle beams as well as in magnet systems. In the future, the beam power in high intensity accelerators will further increase. The protection of the accelerator equipment from the consequences of uncontrolled release of the energy is essential. This was the motivation for organizing a first school on beam losses and accelerator protection (in general referred to as machine protection). During the school the methods and technologies to identify, mitigate, monitor and manage the technical risks associated with the operation of accelerators with high-power beams or subsystems with large stored energy were presented. At the completion of the school the participants should have been able to understand the physical phenomena that can damage machine subsystems or interrupt operations and to analyze an accelerator facility to produce a register of technical risks and the corresponding risk mitigation and management strategie...

Can Accelerators Accelerate Learning?

International Nuclear Information System (INIS)

Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

2009-01-01

The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ)[1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

Can Accelerators Accelerate Learning?

Science.gov (United States)

Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

2009-03-01

The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ) [1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

Measuring high-sensitivity cardiac troponin T blood concentration in population surveys.

OpenAIRE

Lazzarino, AI; Mindell, JS

2017-01-01

Introduction The blood test for high-sensitivity cardiac troponin T (HS-CTnT) has been proposed as a marker of cardiovascular risk in the general population, as it is associated with subsequent incidence of cardiovascular events and mortality. We aimed at evaluating the feasibility of HS-CTnT testing within large nationally-representative population surveys in which blood samples are collected during household visits, shipped using the standard civil postal service, and then frozen for subseq...

Measuring high-sensitivity cardiac troponin T blood concentration in population surveys

OpenAIRE

Lazzarino, A. I.; Mindell, J. S.

2017-01-01

INTRODUCTION: The blood test for high-sensitivity cardiac troponin T (HS-CTnT) has been proposed as a marker of cardiovascular risk in the general population, as it is associated with subsequent incidence of cardiovascular events and mortality. We aimed at evaluating the feasibility of HS-CTnT testing within large nationally-representative population surveys in which blood samples are collected during household visits, shipped using the standard civil postal service, and then frozen for subse...

Plasma accelerators

International Nuclear Information System (INIS)

Bingham, R.; Angelis, U. de; Johnston, T.W.

1991-01-01

Recently attention has focused on charged particle acceleration in a plasma by a fast, large amplitude, longitudinal electron plasma wave. The plasma beat wave and plasma wakefield accelerators are two efficient ways of producing ultra-high accelerating gradients. Starting with the plasma beat wave accelerator (PBWA) and laser wakefield accelerator (LWFA) schemes and the plasma wakefield accelerator (PWFA) steady progress has been made in theory, simulations and experiments. Computations are presented for the study of LWFA. (author)

High-current heavy-ion accelerator system and its application to material modification

International Nuclear Information System (INIS)

Kishimoto, Naoki; Takeda, Yoshihiko; Lee, C.G.; Umeda, Naoki; Okubo, Nariaki; Iwamoto, Eiji

2001-01-01

A high-current heavy-ion accelerator system has been developed to realize intense particle fluxes for material modification. The facility of a tandem accelerator attained 1 mA-class ion current both for negative low-energy ions and positive high-energy ions. The negative ion source of the key device is of the plasma-sputter type, equipped with mutli-cusp magnets and Cs supply. The intense negative ions are either directly used for material irradiation at 60 keV or further accelerated up to 6 MeV after charge transformation. Application of negative ions, which alleviates surface charging, enables us to conduct low-energy high-current irradiation on insulating substrates. Since positive ions above the MeV range are irrelevant for Coulomb repulsion, the facility as a whole meets the needs of high-current irradiation onto insulators over a wide energy range. Application of high flux ions provides technological merits not only for efficient implantation but also for essentially different material kinetics, which may become an important tool of material modification. Other advantages of the system are co-irradiation by intense laser and in-situ detection of kinetic processes. For examples of material modifications, we present nanoparticle fabrication in insulators, and synergistic phenomena by co-irradiation due to ions and photons. (author)

Commissioning experiences on high voltage generator of 750 KeV DC accelerator at RRCAT, Indore

International Nuclear Information System (INIS)

Banwari, R.; Kasliwal, A.; Pandit, T.G.

2009-01-01

Design approach of high voltage generator for 750 keV DC accelerator, developed at RRCAT Indore, inculcates a unique feature of high frequency operation of symmetrical Cockcroft-Walton voltage generator. Apart from design simplicity and feasibility of modular construction, the high frequency use of symmetrical Cockcroft-Walton circuit gives added advantages of less ripple, better regulation, faster response and low stored energy in the system. Additionally the scheme allows us the use of low voltage, light weight components thus improving the overall economy of the system. The accelerator has been commissioned and made operational at its rated energy of 750 keV in the recent past. With brief introduction on design aspects of high voltage generator and filament power supply of this accelerator, the paper presented here describes the developmental steps of various components with focus on challenges encountered and solutions implemented. Development of high frequency inverter, high voltage ferrite core transformer, compensating inductors, interface bushings, voltage multiplier stack, and filament transformer along with floating power supply for electron emitter of the accelerator has been dealt in detail. The failures encountered during commissioning stages of the accelerator have been reported with measures taken for improvement of the specific components. Intricacies of the reflected capacitance of the multiplier stack and arc-current ground return are also described with their effects on system operation and reliability. (author)

Cardiac complications in diphtheria and predictors of outcomes.

Science.gov (United States)

Samdani, Sunil; Jain, Avani; Meena, Vinod; Meena, C B

2018-01-01

To study the cardiac complications in diphtheria patients and to study the predictors of outcomes. Single centre prospective analysis of cardiac complications in diphtheria patients. In this study, there were 60 patients diagnosed with diphtheria with ECG changes. The ECG changes seen were sinus tachycardia (68.3%), T wave inversion (20%), ST segment depression (13.3%), right bundle branch block (5%), multiple atrial ectopics (3.3%). The case fatality rate in our study was 25% (15 patients). High CPK-MB, myoglobulin and cardiac troponin levels were associated with cardiac mortality. In our study, cardiac troponin T had the highest sensitivity (80%) and CK-MB had the highest specificity (95.56%). Cardiac involvement is a common complication of infection with C. diphtheria and is associated with high mortality. As diphtheria can be prevented by adequate vaccination, efforts should be maximized for high vaccine coverage with booster doses. Copyright © 2017. Published by Elsevier B.V.

High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure.

Science.gov (United States)

Rosa-Garrido, Manuel; Chapski, Douglas J; Schmitt, Anthony D; Kimball, Todd H; Karbassi, Elaheh; Monte, Emma; Balderas, Enrique; Pellegrini, Matteo; Shih, Tsai-Ting; Soehalim, Elizabeth; Liem, David; Ping, Peipei; Galjart, Niels J; Ren, Shuxun; Wang, Yibin; Ren, Bing; Vondriska, Thomas M

2017-10-24

Cardiovascular disease is associated with epigenomic changes in the heart; however, the endogenous structure of cardiac myocyte chromatin has never been determined. To investigate the mechanisms of epigenomic function in the heart, genome-wide chromatin conformation capture (Hi-C) and DNA sequencing were performed in adult cardiac myocytes following development of pressure overload-induced hypertrophy. Mice with cardiac-specific deletion of CTCF (a ubiquitous chromatin structural protein) were generated to explore the role of this protein in chromatin structure and cardiac phenotype. Transcriptome analyses by RNA-seq were conducted as a functional readout of the epigenomic structural changes. Depletion of CTCF was sufficient to induce heart failure in mice, and human patients with heart failure receiving mechanical unloading via left ventricular assist devices show increased CTCF abundance. Chromatin structural analyses revealed interactions within the cardiac myocyte genome at 5-kb resolution, enabling examination of intra- and interchromosomal events, and providing a resource for future cardiac epigenomic investigations. Pressure overload or CTCF depletion selectively altered boundary strength between topologically associating domains and A/B compartmentalization, measurements of genome accessibility. Heart failure involved decreased stability of chromatin interactions around disease-causing genes. In addition, pressure overload or CTCF depletion remodeled long-range interactions of cardiac enhancers, resulting in a significant decrease in local chromatin interactions around these functional elements. These findings provide a high-resolution chromatin architecture resource for cardiac epigenomic investigations and demonstrate that global structural remodeling of chromatin underpins heart failure. The newly identified principles of endogenous chromatin structure have key implications for epigenetic therapy. © 2017 The Authors.

Charged particle accelerator

International Nuclear Information System (INIS)

Arakawa, Kazuo.

1969-01-01

An accelerator is disclosed having a device which permits the electrodes of an accelerator tube to be readily conditioned in an uncomplicated manner before commencing operation. In particle accelerators, it is necessary to condition the accelerator electrodes before a stable high voltage can be applied. Large current accelerators of the cockcroft-walton type require a complicated manual operation which entails applying to the electrodes a low voltage which is gradually increased to induce a vacuum discharge and then terminated. When the discharge attains an extremely low level, the voltage is again impressed and again raised to a high value in low current type accelerators, a high voltage power supply charges the electrodes once to induce discharge followed by reapplying the voltage when the vacuum discharge reaches a low level, according to which high voltage is automatically applied. This procedure, however, requires that the high voltage power supply be provided with a large internal resistance to limit the current to within several milliamps. The present invention connects a high voltage power supply and an accelerator tube through a discharge current limiting resistor wired in parallel with a switch. Initially, the switch is opened enabling the power supply to impress a voltage limited to a prescribed value by a suitably chosen resistor. Conditioning is effected by allowing the voltage between electrodes to increase and is followed by closing the switch through which high voltage is applied directly to the accelerator for operation. (K.J. Owens)

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Directory of Open Access Journals (Sweden)

Gabriele G. Schiattarella

2018-05-01

Full Text Available Left ventricular hypertrophy (LVH is a major contributor to the development of heart failure (HF. Alterations in cyclic adenosine monophosphate (cAMP-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated by a family of cAMP-dependent protein kinase A (PKA anchor proteins (AKAPs, tethering PKA to discrete cellular locations. AKAPs encoded by the Akap1 gene (mitoAKAPs promote PKA mitochondrial targeting, regulating mitochondrial structure and function, reactive oxygen species production, and cell survival. To determine the role of mitoAKAPs in LVH development, in the present investigation, mice with global genetic deletion of Akap1 (Akap1-/-, Akap1 heterozygous (Akap1+/-, and their wild-type (wt littermates underwent transverse aortic constriction (TAC or SHAM procedure for 1 week. In wt mice, pressure overload induced the downregulation of AKAP121, the major cardiac mitoAKAP. Compared to wt, Akap1-/- mice did not display basal alterations in cardiac structure or function and cardiomyocyte size or fibrosis. However, loss of Akap1 exacerbated LVH and cardiomyocyte hypertrophy induced by pressure overload and accelerated the progression toward HF in TAC mice, and these changes were not observed upon prevention of AKAP121 degradation in seven in absentia homolog 2 (Siah2 knockout mice (Siah2-/-. Loss of Akap1 was also associated to a significant increase in cardiac apoptosis as well as lack of activation of Akt signaling after pressure overload. Taken together, these results demonstrate that in vivo genetic deletion of Akap1 enhances LVH development and accelerates pressure overload-induced cardiac dysfunction, pointing at Akap1 as a novel repressor of pathological LVH. These results confirm and extend the important role of mitoAKAPs in cardiac response to stress.

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure.

Science.gov (United States)

Schiattarella, Gabriele G; Boccella, Nicola; Paolillo, Roberta; Cattaneo, Fabio; Trimarco, Valentina; Franzone, Anna; D'Apice, Stefania; Giugliano, Giuseppe; Rinaldi, Laura; Borzacchiello, Domenica; Gentile, Alessandra; Lombardi, Assunta; Feliciello, Antonio; Esposito, Giovanni; Perrino, Cinzia

2018-01-01

Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated by a family of cAMP-dependent protein kinase A (PKA) anchor proteins (AKAPs), tethering PKA to discrete cellular locations. AKAPs encoded by the Akap1 gene (mitoAKAPs) promote PKA mitochondrial targeting, regulating mitochondrial structure and function, reactive oxygen species production, and cell survival. To determine the role of mitoAKAPs in LVH development, in the present investigation, mice with global genetic deletion of Akap1 ( Akap1 -/- ), Akap1 heterozygous ( Akap1 +/- ), and their wild-type ( wt ) littermates underwent transverse aortic constriction (TAC) or SHAM procedure for 1 week. In wt mice, pressure overload induced the downregulation of AKAP121, the major cardiac mitoAKAP. Compared to wt, Akap1 -/- mice did not display basal alterations in cardiac structure or function and cardiomyocyte size or fibrosis. However, loss of Akap1 exacerbated LVH and cardiomyocyte hypertrophy induced by pressure overload and accelerated the progression toward HF in TAC mice, and these changes were not observed upon prevention of AKAP121 degradation in seven in absentia homolog 2 ( Siah2 ) knockout mice ( Siah2 -/- ). Loss of Akap1 was also associated to a significant increase in cardiac apoptosis as well as lack of activation of Akt signaling after pressure overload. Taken together, these results demonstrate that in vivo genetic deletion of Akap1 enhances LVH development and accelerates pressure overload-induced cardiac dysfunction, pointing at Akap1 as a novel repressor of pathological LVH. These results confirm and extend the important role of mitoAKAPs in cardiac response to stress.

Cardiac CT and cardiac MRI - competitive or complementary for nuclear cardiology

International Nuclear Information System (INIS)

Moshage, W.

2004-01-01

In summary, cardiac computed tomography (CT) and cardiac magnetic resonance (MR) are two different technologies with distinct imaging properties that gain increasing importance in clinical cardiology. Even though images may look similar, the areas of application of CT and MR are quite different. Clinical applications of cardiac CT focus on on-invasive imaging of the coronary arteries. In this respect, the higher spatial resolution of cardiac CT constitutes a significant advantage as compared to MR and clinical results are superior. Clinical applications of cardiac MR, next to morphologic imaging of the heart, are most frequently found in the context of intra-and pericardial masses, complex congenital anomalies, and the assessment of left ventricular function (dobutamine) and perfusion (adenosine) under stress. The evaluation of the size and localization of myocardial necrosis, scars, and fibrosis gains increasing importance, for example in the workup of myocardial infarction, but also myocarditis and cardiomyopathies. In this respect, magnetic resonance imaging partly constitutes an alternative to nuclear medicine methods. Due to the lack of ionizing radiation and a relatively high spatial resolution, an increase of MR diagnostic procedures at the expense of nuclear medicine can be expected. (orig.)

Accelerator Technology and High Energy Physic Experiments, WILGA 2012; EuCARD Sessions

CERN Document Server

Romaniuk, R S

2012-01-01

Wilga Sessions on HEP experiments, astroparticle physica and accelerator technology were organized under the umbrella of the EU FP7 Project EuCARD – European Coordination for Accelerator Research and Development. The paper is the second part (out of five) of the research survey of WILGA Symposium work, May 2012 Edition, concerned with accelerator technology and high energy physics experiments. It presents a digest of chosen technical work results shown by young researchers from different technical universities from this country during the XXXth Jubilee SPIE-IEEE Wilga 2012, May Edition, symposium on Photonics and Web Engineering. Topical tracks of the symposium embraced, among others, nanomaterials and nanotechnologies for photonics, sensory and nonlinear optical fibers, object oriented design of hardware, photonic metrology, optoelectronics and photonics applications, photonics-electronics co-design, optoelectronic and electronic systems for astronomy and high energy physics experiments, JET and pi-of-the ...

Accelerated Creep Testing of High Strength Aramid Webbing

Science.gov (United States)

Jones, Thomas C.; Doggett, William R.; Stnfield, Clarence E.; Valverde, Omar

2012-01-01

A series of preliminary accelerated creep tests were performed on four variants of 12K and 24K lbf rated Vectran webbing to help develop an accelerated creep test methodology and analysis capability for high strength aramid webbings. The variants included pristine, aged, folded and stitched samples. This class of webbings is used in the restraint layer of habitable, inflatable space structures, for which the lifetime properties are currently not well characterized. The Stepped Isothermal Method was used to accelerate the creep life of the webbings and a novel stereo photogrammetry system was used to measure the full-field strains. A custom MATLAB code is described, and used to reduce the strain data to produce master creep curves for the test samples. Initial results show good correlation between replicates; however, it is clear that a larger number of samples are needed to build confidence in the consistency of the results. It is noted that local fiber breaks affect the creep response in a similar manner to increasing the load, thus raising the creep rate and reducing the time to creep failure. The stitched webbings produced the highest variance between replicates, due to the combination of higher local stresses and thread-on-fiber damage. Large variability in the strength of the webbings is also shown to have an impact on the range of predicted creep life.

Real-time SPARSE-SENSE cardiac cine MR imaging: optimization of image reconstruction and sequence validation.

Science.gov (United States)

Goebel, Juliane; Nensa, Felix; Bomas, Bettina; Schemuth, Haemi P; Maderwald, Stefan; Gratz, Marcel; Quick, Harald H; Schlosser, Thomas; Nassenstein, Kai

2016-12-01

Improved real-time cardiac magnetic resonance (CMR) sequences have currently been introduced, but so far only limited practical experience exists. This study aimed at image reconstruction optimization and clinical validation of a new highly accelerated real-time cine SPARSE-SENSE sequence. Left ventricular (LV) short-axis stacks of a real-time free-breathing SPARSE-SENSE sequence with high spatiotemporal resolution and of a standard segmented cine SSFP sequence were acquired at 1.5 T in 11 volunteers and 15 patients. To determine the optimal iterations, all volunteers' SPARSE-SENSE images were reconstructed using 10-200 iterations, and contrast ratios, image entropies, and reconstruction times were assessed. Subsequently, the patients' SPARSE-SENSE images were reconstructed with the clinically optimal iterations. LV volumetric values were evaluated and compared between both sequences. Sufficient image quality and acceptable reconstruction times were achieved when using 80 iterations. Bland-Altman plots and Passing-Bablok regression showed good agreement for all volumetric parameters. 80 iterations are recommended for iterative SPARSE-SENSE image reconstruction in clinical routine. Real-time cine SPARSE-SENSE yielded comparable volumetric results as the current standard SSFP sequence. Due to its intrinsic low image acquisition times, real-time cine SPARSE-SENSE imaging with iterative image reconstruction seems to be an attractive alternative for LV function analysis. • A highly accelerated real-time CMR sequence using SPARSE-SENSE was evaluated. • SPARSE-SENSE allows free breathing in real-time cardiac cine imaging. • For clinically optimal SPARSE-SENSE image reconstruction, 80 iterations are recommended. • Real-time SPARSE-SENSE imaging yielded comparable volumetric results as the reference SSFP sequence. • The fast SPARSE-SENSE sequence is an attractive alternative to standard SSFP sequences.

Generation of annular, high-charge electron beams at the Argonne wakefield accelerator

Science.gov (United States)

Wisniewski, E. E.; Li, C.; Gai, W.; Power, J.

2013-01-01

We present and discuss the results from the experimental generation of high-charge annular(ring-shaped)electron beams at the Argonne Wakefield Accelerator (AWA). These beams were produced by using laser masks to project annular laser profiles of various inner and outer diameters onto the photocathode of an RF gun. The ring beam is accelerated to 15 MeV, then it is imaged by means of solenoid lenses. Transverse profiles are compared for different solenoid settings. Discussion includes a comparison with Parmela simulations, some applications of high-charge ring beams,and an outline of a planned extension of this study.

Generation of annular, high-charge electron beams at the Argonne wakefield accelerator

Science.gov (United States)

Wisniewski, E. E.; Li, C.; Gai, W.; Power, J.

2012-12-01

We present and discuss the results from the experimental generation of high-charge annular(ring-shaped)electron beams at the Argonne Wakefield Accelerator (AWA). These beams were produced by using laser masks to project annular laser profiles of various inner and outer diameters onto the photocathode of an RF gun. The ring beam is accelerated to 15 MeV, then it is imaged by means of solenoid lenses. Transverse profiles are compared for different solenoid settings. Discussion includes a comparison with Parmela simulations, some applications of high-charge ring beams,and an outline of a planned extension of this study.

Cardiac regeneration therapy: connections to cardiac physiology.

Science.gov (United States)

Takehara, Naofumi; Matsubara, Hiroaki

2011-12-01

Without heart transplantation, a large number of patients with failing hearts worldwide face poor outcomes. By means of cardiomyocyte regeneration, cardiac regeneration therapy is emerging with great promise as a means for restoring loss of cardiac function. However, the limited success of clinical trials using bone marrow-derived cells and myoblasts with heterogeneous constituents, transplanted at a wide range of cell doses, has led to disagreement on the efficacy of cell therapy. It is therefore essential to reevaluate the evidence for the efficacy of cell-based cardiac regeneration therapy, focusing on targets, materials, and methodologies. Meanwhile, the revolutionary innovation of cardiac regeneration therapy is sorely needed to help the millions of people who suffer heart failure from acquired loss of cardiomyocytes. Cardiac regeneration has been used only in limited species or as a developing process in the rodent heart; now, the possibility of cardiomyocyte turnover in the human heart is being revisited. In the pursuit of this concept, the use of cardiac stem/progenitor stem cells in the cardiac niche must be focused to usher in a second era of cardiac regeneration therapy for the severely injured heart. In addition, tissue engineering and cellular reprogramming will advance the next era of treatment that will enable current cell-based therapy to progress to "real" cardiac regeneration therapy. Although many barriers remain, the prevention of refractory heart failure through cardiac regeneration is now becoming a realistic possibility.

A Two-dimensional Sixteen Channel Transmit/Receive Coil Array for Cardiac MRI at 7.0 Tesla: Design, Evaluation and Application

Science.gov (United States)

Thalhammer, Christof; Renz, Wolfgang; Winter, Lukas; Hezel, Fabian; Rieger, Jan; Pfeiffer, Harald; Graessl, Andreas; Seifert, Frank; Hoffmann, Werner; von Knobelsdorff-Brenkenhoff, Florian; Tkachenko, Valeriy; Schulz-Menger, Jeanette; Kellman, Peter; Niendorf, Thoralf

2012-01-01

Purpose To design, evaluate and apply a two-dimensional 16 channel transmit/receive coil array tailored for cardiac MRI at 7.0 Tesla. Material and Methods The cardiac coil array consists of 2 sections each using 8 elements arranged in a 2 × 4 array. RF safety was validated by SAR simulations. Cardiac imaging was performed using 2D CINE FLASH imaging, T2* mapping and fat-water separation imaging. The characteristics of the coil array were analyzed including parallel imaging performance, left ventricular chamber quantification and overall image quality. Results RF characteristics were found to be appropriate for all subjects included in the study. The SAR values derived from the simulations fall well in the limits of legal guidelines. The baseline SNR advantage at 7.0 T was put to use to acquire 2D CINE images of the heart with a very high spatial resolution of (1 × 1 × 4) mm3. The proposed coil array supports 1D acceleration factors of up to R=4 without impairing image quality significantly. Conclusions The 16 channel TX/RX coil has the capability to acquire high contrast and high spatial resolution images of the heart at 7.0 Tesla. PMID:22706727

Cardiac pacing systems and implantable cardiac defibrillators (ICDs): a radiological perspective of equipment, anatomy and complications

Energy Technology Data Exchange (ETDEWEB)

Burney, K. E-mail: apqz59@dsl.pipex.comk1511@hotmail.com; Burchard, F.; Papouchado, M.; Wilde, P

2004-08-01

Cardiac pacing is a proven and effective treatment in the management of many cardiac arrhythmias. Implantable cardiac defibrillators (ICDs) are beneficial for certain patient groups with a history of serious, recurrent ventricular dysrhythmias, with a high risk of sudden cardiac death. Pacemaker devices take many forms and are highly visible on the chest radiograph. The radiographic appearances of ICDs and pacemakers can be similar and are subject to similar complications. The anatomical approach to the implantation, the type of device used and anatomical variations will all affect the appearance of these devices on the chest film. Pacemaker complications identified radiographically include pneumothorax, lead malpositioning, lead displacement or fracture, fracture of outer conductor coil, loose connection between the lead and pacemaker connector block, lack of redundant loops in paediatric patients and excessive manipulation of the device by the patient (Twiddler's syndrome). This pictorial review highlights the role of chest radiography in the diagnosis of post-cardiac pacing and ICD insertion complications, as well as demonstrating the normal appearances of the most frequently implanted devices.

A systematic review of basic life support training targeted to family members of high-risk cardiac patients.

Science.gov (United States)

Cartledge, Susie; Bray, Janet E; Leary, Marion; Stub, Dion; Finn, Judith

2016-08-01

Targeting basic life support (BLS) training to bystanders who are most likely to witness an out of hospital cardiac arrest (OHCA) is an important public health intervention. We performed a systematic review examining the evidence of the effectiveness of providing BLS training to family members of high-risk cardiac patients. A search of Ovid MEDLINE, CINAL, EMBASE, Informit, Cochrane Library, Web of Science, Scopus, ERIC and ProQuest Dissertations and Theses Global was conducted. We included all studies training adult family members of high-risk cardiac patients regardless of methods used for cardiopulmonary resuscitation (CPR) or BLS training. Two reviewers independently extracted data and evaluated the quality of evidence using GRADE (Grades of Recommendation, Assessment, Development and Evaluation). We included 26 of the 1172 studies identified. The majority of studies were non-randomised controlled trials (n=18), of very low to moderate quality. Currently, there is insufficient evidence to indicate a benefit of this intervention for patients; largely because of low numbers of OHCA events and high loss to follow-up. However, the majority of trained individuals were able to competently perform BLS skills, reported a willingness to use these skills and experienced lower anxiety. Whilst there is no current evidence for improvement in patient outcomes from targeted BLS training for family members, this group are willing and capable to learn these skills. Future research may need to examine longer periods of follow-up using alternate methods (e.g. cardiac arrest registries), and examine the effectiveness of training in the modern era. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A conceptual design of the DTL-SDTL for the JAERI high intensity proton accelerator

Energy Technology Data Exchange (ETDEWEB)

Ino, Hiroshi; Kabeya, Zenzaburo [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Chishiro, Etsuji; Ouchi, Nobuo; Hasegawa, Kazuo; Mizumoto, Motoharu

1998-08-01

A high intensity proton linear accelerator with an energy of 1.5 GeV and an average beam power of 8 MW has been proposed for the Neutron Science Project (NSP) at JAERI. This linac starts with radio-frequency quadrupole (RFQ) linac, which is followed by a drift-tube linac (DTL), separated-type DTL (SDTL), and a superconducting structure. In this report, we focus on the DTL and SDTL part of the accelerator. The DTL accelerates the beam from 2 to 51 MeV, and SDTL accelerates the beam from 51 to 10 MeV. Since the main features of the requirement for the DTL-SDTL are high peak current ({approx}30 mA) and a high-duty factor ({approx}CW), the conceptual design should be determined not only based on the result of a beam-dynamics calculation, but by careful study of the cooling problems. The design processes of the DTL-SDTL and the matching sections (RFQ to DTL, CW-Pulse merge section, and SDTL to SCC) and the result of a heat transfer analysis of DTL are described. (author)

Resent advance in electron linear accelerators

International Nuclear Information System (INIS)

Takeda, Seishi; Tsumori, Kunihiko; Takamuku, Setsuo; Okada, Toichi; Hayashi, Koichiro; Kawanishi, Masaharu

1986-01-01

In recently constructed electron linear accelerators, there has been remarkable advance both in acceleration of a high-current single bunch electron beam for radiation research and in generation of high accelerating gradient for high energy accelerators. The ISIR single bunch electron linear accelerator has been modified an injector to increase a high-current single bunch charge up to 67 nC, which is ten times greater than the single bunch charge expected in early stage of construction. The linear collider projects require a high accelerating gradient of the order of 100 MeV/m in the linear accelerators. High-current and high-gradient linear accelerators make it possible to obtain high-energy electron beam with small-scale linear accelerators. The advance in linear accelerators stimulates the applications of linear accelerators not only to fundamental research of science but also to industrial uses. (author)

Study of laser driven plasma based electron acceleration and Bremsstrahlung radiation emission using ultra-high intensity laser pulses

International Nuclear Information System (INIS)

Rao, B.S.

2013-01-01

High energy particle accelerators are one of the most important inventions of the twentieth century which have led to enormous advances in basic scientific understanding of world around us. Despite their grand success, the present day high energy accelerators are hitting practical limits due to their large size and cost. This is because the accelerating gradients in conventional radio-frequency (RF) accelerators are typically limited to < 50 MV/m by the field breakdown of the accelerating structure. To address this major issue, many advanced accelerator techniques have been proposed and some of them are being actively pursued. Laser wakefield acceleration (LWFA) in plasma medium is one of the techniques being most actively pursued world over due to extremely large acceleration gradients of the order of 100 GV/m possible in this scheme which promises significant reduction of the size and cost of the future high energy accelerators. The present thesis work mainly deals with laser wakefield acceleration (LWFA) of self-injected electrons to 10s of MeV energy in plasma medium of length of the order of 500 μm using the table-top 10 TW laser at Laser Plasma Division, Raja Ramanna Centre for Advanced Technology

Drug-Induced Rhabdomyolysis with Elevated Cardiac Troponin T

Directory of Open Access Journals (Sweden)

Gro Egholm

2015-01-01

Full Text Available The essential role of cardiac troponin in the diagnosis of acute myocardial infarction has led to the development of high-sensitivity assays, which are able to detect very small amounts of myocardial necrosis. The high-sensitivity cardiac troponin T assay, however, is not entirely specific for myocardial injury. This case report describes a 48-year-old woman, who, two years after cardiac transplantation, presented with rhabdomyolysis. During the course of the disease, her troponin T level was elevated on repeated occasions, but other definitive evidence of myocardial injury was not found. Asymptomatic cardiac troponin T elevations during rhabdomyolysis may be due to either cardiac involvement or false positive results stemming from skeletal muscle injury.

A randomized controlled trial of levosimendan to reduce mortality in high-risk cardiac surgery patients (CHEETAH): Rationale and design.

Science.gov (United States)

Zangrillo, Alberto; Alvaro, Gabriele; Pisano, Antonio; Guarracino, Fabio; Lobreglio, Rosetta; Bradic, Nikola; Lembo, Rosalba; Gianni, Stefano; Calabrò, Maria Grazia; Likhvantsev, Valery; Grigoryev, Evgeny; Buscaglia, Giuseppe; Pala, Giovanni; Auci, Elisabetta; Amantea, Bruno; Monaco, Fabrizio; De Vuono, Giovanni; Corcione, Antonio; Galdieri, Nicola; Cariello, Claudia; Bove, Tiziana; Fominskiy, Evgeny; Auriemma, Stefano; Baiocchi, Massimo; Bianchi, Alessandro; Frontini, Mario; Paternoster, Gianluca; Sangalli, Fabio; Wang, Chew-Yin; Zucchetti, Maria Chiara; Biondi-Zoccai, Giuseppe; Gemma, Marco; Lipinski, Michael J; Lomivorotov, Vladimir V; Landoni, Giovanni

2016-07-01

Patients undergoing cardiac surgery are at risk of perioperative low cardiac output syndrome due to postoperative myocardial dysfunction. Myocardial dysfunction in patients undergoing cardiac surgery is a potential indication for the use of levosimendan, a calcium sensitizer with 3 beneficial cardiovascular effects (inotropic, vasodilatory, and anti-inflammatory), which appears effective in improving clinically relevant outcomes. Double-blind, placebo-controlled, multicenter randomized trial. Tertiary care hospitals. Cardiac surgery patients (n = 1,000) with postoperative myocardial dysfunction (defined as patients with intraaortic balloon pump and/or high-dose standard inotropic support) will be randomized to receive a continuous infusion of either levosimendan (0.05-0.2 μg/[kg min]) or placebo for 24-48 hours. The primary end point will be 30-day mortality. Secondary end points will be mortality at 1 year, time on mechanical ventilation, acute kidney injury, decision to stop the study drug due to adverse events or to start open-label levosimendan, and length of intensive care unit and hospital stay. We will test the hypothesis that levosimendan reduces 30-day mortality in cardiac surgery patients with postoperative myocardial dysfunction. This trial is planned to determine whether levosimendan could improve survival in patients with postoperative low cardiac output syndrome. The results of this double-blind, placebo-controlled randomized trial may provide important insights into the management of low cardiac output in cardiac surgery. Copyright © 2016 Elsevier Inc. All rights reserved.

Radiation Fields in High Energy Accelerators and their impact on Single Event Effects

CERN Document Server

García Alía, Rubén; Wrobel, Frédéric; Brugger, Markus

Including calculation models and measurements for a variety of electronic components and their concerned radiation environments, this thesis describes the complex radiation field present in the surrounding of a high-energy hadron accelerator and assesses the risks related to it in terms of Single Event Effects (SEE). It is shown that this poses not only a serious threat to the respective operation of modern accelerators but also highlights the impact on other high-energy radiation environments such as those for ground and avionics applications. Different LHC-like radiation environments are described in terms of their hadron composition and energy spectra. They are compared with other environments relevant for electronic component operation such as the ground-level, avionics or proton belt. The main characteristic of the high-energy accelerator radiation field is its mixed nature, both in terms of hadron types and energy interval. The threat to electronics ranges from neutrons of thermal energies to GeV hadron...

Multiperiodic accelerator structures for linear particle accelerators

International Nuclear Information System (INIS)

Tran, D.T.

1975-01-01

High efficiency linear accelerator structures, comprised of a succession of cylindrical resonant cavities for acceleration, are described. Coupling annular cavities are located at the periphery, each being coupled to two adjacent cylindrical cavities. (auth)

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure.

Science.gov (United States)

Morine, Kevin J; Qiao, Xiaoying; York, Sam; Natov, Peter S; Paruchuri, Vikram; Zhang, Yali; Aronovitz, Mark J; Karas, Richard H; Kapur, Navin K

2018-02-27

Background -Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counter-regulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a member of the TGFβ family of cytokines and signals via the downstream effector protein Smad1. Endoglin is a TGFβ co-receptor that promotes TGF-β1 signaling via Smad3 and binds BMP9 with high affinity. We hypothesized that BMP9 limits cardiac fibrosis by activating Smad1 and attenuating Smad3 and further that neutralizing endoglin activity promotes BMP9 activity. Methods -We examined BMP9 expression and signaling in human cardiac fibroblasts and human subjects with heart failure. We utilized the thoracic aortic constriction (TAC) induced model of heart failure to evaluate the functional effect of BMP9 signaling on cardiac remodeling. Results -BMP9 expression is increased in the circulation and left ventricle (LV) of human subjects with heart failure and is expressed by cardiac fibroblasts. Next, we observed that BMP9 attenuates Type I collagen synthesis in human cardiac fibroblasts using recombinant human BMP9 and an siRNA approach. In BMP9 -/- mice subjected to TAC, loss of BMP9 activity promotes cardiac fibrosis, impairs LV function, and increases LV levels of phosphorylated Smad3 (pSmad3), not pSmad1. In contrast, treatment of wild-type mice subjected to TAC with recombinant BMP9 limits progression of cardiac fibrosis, improves LV function, enhances myocardial capillary density, and increases LV levels of pSmad1, not pSmad3 compared to vehicle treated controls. Since endoglin binds BMP9 with high affinity, we explored the effect of reduced endoglin activity on BMP9 activity. Neutralizing endoglin activity in human cardiac fibroblasts or in wild-type mice subjected to TAC induced heart failure limits collagen production, increases BMP9 protein levels, and increases

Design of high-speed data transmission system for Lanzhou heavy ion therapy accelerator

International Nuclear Information System (INIS)

Mao Wenyu; Qiao Weimin; Jing Lan; Li Guihua

2012-01-01

In order to satisfy the transmission requirements of partial synchronization data and process data for the heavy ion therapy accelerator, a high-speed, error-correction, long-distance, and real-time data transmission system was proposed and achieved. It can improve the efficiency and reliability of the accelerator control and synchronization. The system optimizes the hardware configuration and layout of the traditional system. FPGA, gigabit fiber module, PXI and SDRAM are the main parts of the system. It replaces the low-speed, short-distance, and poor anti-interference of the traditional data path and the data processing chips. Through the programming in the two FPGA chips, the PXI and DMA transmission mode was used to exchange data with the server of the accelerator. The front-end of the system achieves a real-time, long-distance, and high-speed serial frame transmission with 800 MHz carrier and 100 MHz base band signal. The real-time -data like synchronous event signal, power waveform data of the heavy ion therapy accelerator can be transmitted efficiently between the server and the remote controller through the system. (authors)

Community petascale project for accelerator science and simulation: Advancing computational science for future accelerators and accelerator technologies

International Nuclear Information System (INIS)

Spentzouris, P.; Cary, J.; McInnes, L.C.; Mori, W.; Ng, C.; Ng, E.; Ryne, R.

2008-01-01

The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R and D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.

Analysis and design of a slotless tubular permanent magnet actuator for high acceleration applications

NARCIS (Netherlands)

Meessen, K.J.; Paulides, J.J.H.; Lomonova, E.A.

2009-01-01

This paper presents the design of a linear actuator for high acceleration applications. In the analysis, a slotless tubular permanent magnet actuator is modeled by means of semianalytical field solutions. Several slotless topologies are modeled and compared to achieve the highest acceleration. A

Accelerations in Flight

Science.gov (United States)

Doolittle, J H

1925-01-01

This work on accelerometry was done at McCook Field for the purpose of continuing the work done by other investigators and obtaining the accelerations which occur when a high-speed pursuit airplane is subjected to the more common maneuvers. The accelerations obtained in suddenly pulling out of a dive with well-balanced elevators are shown to be within 3 or 4 per cent of the theoretically possible accelerations. The maximum acceleration which a pilot can withstand depends upon the length of time the acceleration is continued. It is shown that he experiences no difficulty under the instantaneous accelerations as high as 7.8 G., but when under accelerations in excess of 4.5 G., continued for several seconds, he quickly loses his faculties.

The IBA rhodotron TT1000: a very high power E-beam accelerator

International Nuclear Information System (INIS)

Abs, M.; Jongen, Y.; Poncelet, E.; Bol, J.-L.

2004-01-01

Due to the relatively low conversion efficiency of electrons into X-rays, the use of X-rays on an industrial basis requires high-power high-energy electron accelerators. Based on its experience acquired in the development of the Rhodotron (Nucl. Instrum. Methods B 40/41 (1989) 943; Nucl. Instrum. Methods B 79 (1993) 865), IBA has launched a few years ago a vigorous R and D program to develop such high-power electron accelerator devoted to X-ray industrial applications. This research program resulted in the TT1000 Rhodotron aimed at delivering 5 and 7 MeV electron beams with a current intensity of 100 mA. This project is now reaching its final phase with the qualification tests of the first prototype of this new machine

Practical high-density shielding materials for medical linear accelerator rooms

International Nuclear Information System (INIS)

Barish, R.J.

1990-01-01

High-energy linear accelerators are replacing lower energy units in radiation therapy centers. Radiation protection requirements necessitate expensive reconstruction of existing treatment rooms to accommodate these new machines. We describe two shielding materials: one made by embedding small pieces of scrap steel in cement, and the other made with cast iron in cement. Both materials produce high-density barriers at low cost using standard construction methods

Synthetic acceleration methods for linear transport problems with highly anisotropic scattering

International Nuclear Information System (INIS)

Khattab, K.M.; Larsen, E.W.

1992-01-01

The diffusion synthetic acceleration (DSA) algorithm effectively accelerates the iterative solution of transport problems with isotropic or mildly anisotropic scattering. However, DSA loses its effectiveness for transport problems that have strongly anisotropic scattering. Two generalizations of DSA are proposed, which, for highly anisotropic scattering problems, converge at least an order of magnitude (clock time) faster than the DSA method. These two methods are developed, the results of Fourier analysis that theoretically predict their efficiency are described, and numerical results that verify the theoretical predictions are presented. (author). 10 refs., 7 figs., 5 tabs

Synthetic acceleration methods for linear transport problems with highly anisotropic scattering

International Nuclear Information System (INIS)

Khattab, K.M.; Larsen, E.W.

1991-01-01

This paper reports on the diffusion synthetic acceleration (DSA) algorithm that effectively accelerates the iterative solution of transport problems with isotropic or mildly anisotropic scattering. However, DSA loses its effectiveness for transport problems that have strongly anisotropic scattering. Two generalizations of DSA are proposed, which, for highly anisotropic scattering problems, converge at least an order of magnitude (clock time) faster than the DSA method. These two methods are developed, the results of Fourier analyses that theoretically predict their efficiency are described, and numerical results that verify the theoretical predictions are presented

Social inequality in phase II cardiac rehabilitation attendance

DEFF Research Database (Denmark)

Pedersen, Maria; Egerod, Ingrid; Overgaard, Dorthe

2018-01-01

: Thirty per cent attended full cardiac rehabilitation. Patients with low educational attainment, comorbidities, long commute to cardiac rehabilitation centre, and lone dwelling were less likely to attend full cardiac rehabilitation, whereas patients with high anxiety and depression score were more likely...

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

Directory of Open Access Journals (Sweden)

Georges N. Kanaan

2018-04-01

Full Text Available Glutaredoxin 2 (GRX2, a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and cardiac hypertrophy in mice but the impact on mitochondrial structure and function in intact cardiomyocytes and in humans has not been explored. We hypothesized that Grx2 controls cardiac mitochondrial dynamics and function in cellular and mouse models, and that low expression is associated with human cardiac dysfunction. Here we show that Grx2 absence impairs mitochondrial fusion, ultrastructure and energetics in primary cardiomyocytes and cardiac tissue. Moreover, provision of the glutathione precursor, N-acetylcysteine (NAC to Grx2-/- mice did not restore glutathione redox or prevent impairments. Using genetic and histopathological data from the human Genotype-Tissue Expression consortium we demonstrate that low GRX2 is associated with fibrosis, hypertrophy, and infarct in the left ventricle. Altogether, GRX2 is important in the control of cardiac mitochondrial structure and function, and protects against human cardiac pathologies. Keywords: Human heart, Mitochondria, Oxidative stress, Redox, Cardiac metabolism, Cardiac hypertrophy

High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.

Science.gov (United States)

Li, Yuquan; Cheng, Lihong; Qin, Qianhong; Liu, Jian; Lo, Woo-kuen; Brako, Lowrence A; Yang, Qinglin

2009-10-01

Peroxisome proliferator-activated receptor delta (PPARdelta) is an essential determinant of basal myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether increased lipid loading affects the PPARdelta deficient heart in transcriptional regulation of FAO and in the development of cardiac pathology. Cardiomyocyte-restricted PPARdelta knockout (CR-PPARdelta(-/-)) and control (alpha-MyHC-Cre) mice were subjected to 48 h of fasting and to a long-term maintenance on a (28 weeks) high-fat diet (HFD). The expression of key FAO proteins in heart was examined. Serum lipid profiles, cardiac pathology, and changes of various transduction signaling pathways were also examined. Mice subjected to fasting exhibited upregulated transcript expression of FAO genes in the CR-PPARdelta(-/-) hearts. Moreover, long-term HFD in CR-PPARdelta(-/-) mice induced a strikingly greater transcriptional response. After HFD, genes encoding key FAO enzymes were expressed remarkably more in CR-PPARdelta(-/-) hearts than in those of control mice. Despite the marked rise of FAO gene expression, corresponding protein expression remained low in the CR-PPARdelta(-/-) heart, accompanied by abnormalities in sarcomere structures and mitochondria that were similar to those of CR-PPARdelta(-/-) hearts with regular chow feeding. The CR-PPARdelta(-/-) mice displayed increased expression of PPARgamma co-activator-1alpha (PGC-1alpha) and PPARalpha in the heart with deactivated Akt and p42/44 MAPK signaling in response to HFD. We conclude that PPARdelta is an essential determinant of myocardial FAO. Increased lipid intake activates cardiac expression of FAO genes via PPARalpha/PGC-1alpha pathway, albeit it is not sufficient to improve cardiac pathology due to PPARdelta deficiency.

Therapy with mesenchymal stromal cells or conditioned medium reverse cardiac alterations in a high-fat diet-induced obesity model.

Science.gov (United States)

Daltro, P S; Barreto, B C; Silva, P G; Neto, P Chenaud; Sousa Filho, P H F; Santana Neta, D; Carvalho, G B; Silva, D N; Paredes, B D; de Alcantara, A C; Freitas, L A R; Couto, R D; Santos, R R; Souza, B S F; Soares, M B P; Macambira, S G

2017-10-01

Obesity is associated with numerous cardiac complications, including arrhythmias, cardiac fibrosis, remodeling and heart failure. Here we evaluated the therapeutic potential of mesenchymal stromal cells (MSCs) and their conditioned medium (CM) to treat cardiac complications in a mouse model of high-fat diet (HFD)-induced obesity. After obesity induction and HFD withdrawal, obese mice were treated with MSCs, CM or vehicle. Cardiac function was assessed using electrocardiography, echocardiography and treadmill test. Body weight and biochemical parameters were evaluated. Cardiac tissue was used for real time (RT)-polymerase chain reaction (PCR) and histopathologic analysis. Characterization of CM by protein array showed the presence of different cytokines and growth factors, including chemokines, osteopontin, cystatin C, Serpin E1 and Gas 6. HFD-fed mice presented cardiac arrhythmias, altered cardiac gene expression and fibrosis reflected in physical exercise incapacity associated with obesity and diabetes. Administration of MSCs or CM improved arrhythmias and exercise capacity. This functional improvement correlated with normalization of GATA4 gene expression in the hearts of MSC- or CM-treated mice. The gene expression of connexin 43, troponin I, adiponectin, transforming growth factor (TGF) β, peroxisome proliferator activated receptor gamma (PPARγ), insulin-like growth factor 1 (IGF-1), matrix metalloproteinase-9 (MMP9) and tissue inhibitor of metalloproteinases 1 (TIMP1) were significantly reduced in MSCs, but not in CM-treated mice. Moreover, MSC or CM administration reduced the intensity of cardiac fibrosis. Our results suggest that MSCs and CM have a recovery effect on cardiac disturbances due to obesity and corroborate to the paracrine action of MSCs in heart disease models. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

High voltage tests of an electrostatic accelerator for different mixtures of gases at various pressures

International Nuclear Information System (INIS)

Hellborg, R.

1996-01-01

An account is given of high voltage tests of an electrostatic accelerator. High voltage conditioning is measured and is reported for the same accelerator tube after different periods of usage. Tests of different mixtures of sulphur hexafluoride and nitrogen have been performed. A considerable amount of data was obtained for various parameters connected with the high voltage system for different proportions of nitrogen in sulphur hexafluoride at various gas pressures. (orig.)

Accelerated Irradiations for High Dose Microstructures in Fast Reactor Alloys

Energy Technology Data Exchange (ETDEWEB)

Jiao, Zhijie [Univ. of Michigan, Ann Arbor, MI (United States)

2017-03-31

The objective of this project is to determine the extent to which high dose rate, self-ion irradiation can be used as an accelerated irradiation tool to understand microstructure evolution at high doses and temperatures relevant to advanced fast reactors. We will accomplish the goal by evaluating phase stability and swelling of F-M alloys relevant to SFR systems at very high dose by combining experiment and modeling in an effort to obtain a quantitative description of the processes at high and low damage rates.

Safety management of a high energy accelerator used in the production of tritium

International Nuclear Information System (INIS)

Stark, R.M.; Brown, N.W.; Allen C.L.

1997-01-01

Interest in a high energy accelerator for producing tritium raises considerations regarding facility Safety Management. Accelerator facility hazards require safety analysis to consider factors such as: safe management of a large flux of very high energy neutrons, sustained operation in a very high energy proton and neutron field, neutron irradiation of a variety of materials, and handling and processing of significant quantities of tritium. Safety considerations of support systems and potential effects of magnetic fields must also be included. Existing Safety Management techniques, safety standards, and criteria for operation of high energy accelerators provide considerable guidance. These must, however, be reviewed to determine their appropriate use for safe operation of a very large, tritium-producing accelerator. New or revised safety standards may be required to establish and maintain the safe operating-envelope. The goal will be to develop a set of tailored standards and criteria that provide a reasonable operational envelope and assure adequate public, worker, and environmental safety. The generation of an appropriate set of safety standards and criteria will include several activities. One activity will involve evaluation of proposed facility designs to determine possible hazards. Another activity will involve a detailed review of existing accelerator safety management systems. A third activity will involve the review of operating histories of existing facilities. Facilities approximating the characteristics of the anticipated tritium production facility will be considered. Following completion of these activities a proposed Safety Management System and criteria for application to these facilities will be drafted. The need for new analytical methods and for additional safety standards will be identified. The draft document will then be reviewed and revised to establish the standards and criteria within the appropriate Department of Energy framework

High-powered pulsed-ion-beam acceleration and transport

Energy Technology Data Exchange (ETDEWEB)

Humphries, S. Jr.; Lockner, T.R.

1981-11-01

The state of research on intense ion beam acceleration and transport is reviewed. The limitations imposed on ion beam transport by space charge effects and methods available for neutralization are summarized. The general problem of ion beam neutralization in regions free of applied electric fields is treated. The physics of acceleration gaps is described. Finally, experiments on multi-stage ion acceleration are summarized.

High-powered pulsed-ion-beam acceleration and transport

International Nuclear Information System (INIS)

Humphries, S. Jr.; Lockner, T.R.

1981-11-01

The state of research on intense ion beam acceleration and transport is reviewed. The limitations imposed on ion beam transport by space charge effects and methods available for neutralization are summarized. The general problem of ion beam neutralization in regions free of applied electric fields is treated. The physics of acceleration gaps is described. Finally, experiments on multi-stage ion acceleration are summarized

The generation of high fields for particle acceleration to very high energies

International Nuclear Information System (INIS)

1985-01-01

A Workshop organised by the CERN Accelerator School, the European Committee for Future Accelerators and the Istituto Nazionale di Fisica Nucleare was held at the Frascati laboratory of INFN during the last week of September 1984. Its purpose was to bring together an inter-disciplinary group of physicists to review ideas for the acceleration of particles to energies beyond those attainable in machines whose construction is underway, or is currently contemplated. These proceedings contain some of the material presented and discussed at the Workshop, comprising papers on topics such as: the free-electron-laser, the lasertron, wakefield accelerators, the laser excitation of droplet arrays, a switched-power linac, plasma beat-wave accelerators and the choice of basic parameters for linear colliders intended for the TeV energy region. (orig.)

The longitudinal space charge problem in the high current linear proton accelerators

International Nuclear Information System (INIS)

Lustfeld, H.

1984-01-01

In a linear proton accelerator peak currents of 200 mA lead to high space charge densities and the resultant space charge forces reduce the effective focussing considerably. In particular the longitudinal focussing is affected. A new concept based on linear theory is proposed that restricts the influence of the space charge forces on the longitudinal focussing by increasing a, the mean transverse bunch radius, as a proportional(βγ)sup(3/8). This concept is compared with other concepts for the Alvarez (1 MeV - 100 MeV) and for the high energy part (100 MeV - 1100 MeV) of the SNQ linear accelerator. (orig.)

Use of the cardiopulmonary flow index to evaluate cardiac function in thoroughbred horses

International Nuclear Information System (INIS)

Guthrie, A.J.; Killeen, V.M.; Grosskopf, J.F.W.

1991-01-01

The ratio of the cardiopulmonary blood volume to stroke volume is called the cardiopulmonary flow index (CPFI). The CPFI can be determined indirectly from the simultaneous recording of a radiocardiogram and an electrocardiogram. The CPFI and cardiac output were measured simultaneously in horses that were diagnosed as having cardiac disease. The results obtained from these subjects were compared with those from control animals and significant differences were found between the mean CPFI of the control horses and those with macroscopically visible myocardial fibrosis on post mortem examination. No significant differences were found between the means of the cardiac output measured in either of the groups of horses. The effect of pharmacological acceleration of the heart rate on the CPFI was also studied. Significant differences were found between the mean CPFI and the slopes of the regression lines of CPFI on heart rate of the control and principal groups of horses. These differences were greatest at heart rates near to the resting heart rates of the individuals. The CPFI was found to be a more sensitive measure of cardiac function than cardiac output, in the horses. 16 refs., 2 figs., 2 tabs

Role of advanced RF/microwave technology and high power switch technology for developing/upgrading compact/existing accelerators

International Nuclear Information System (INIS)

Shrivastava, Purushottam

2001-01-01

With the advances in high power microwave devices as well as in microwave technologies it has become possible to go on higher frequencies at higher powers as well as to go for newer devices which are more efficient and compact and hence reducing the power needs as well as space and weight requirement for accelerators. New devices are now available in higher frequency spectrum for example at C-Band, X-band and even higher. Also new devices like klystrodes/Higher Order Mode Inductive Output Tubes (HOM IOTs) are now becoming competitors for existing tubes which are in use at present accelerator complexes. The design/planning of the accelerators used for particle physics research, medical accelerators, industrial irradiation, or even upcoming Driver Accelerators for Sub Critical Reactors for nuclear power generation are being done taking into account the newer technologies. The accelerators which use magnetrons, klystrons and similar devices at S-Band can be modified/redesigned with devices at higher frequencies like X-Band. Pulsed accelerators need high power high voltage pulsed modulators whereas CW accelerators need high voltage power supplies for functioning of RF / Microwave tubes. There had been a remarkable growth in the development and availability of solid state switches both for switching the pulsed modulators for microwave tubes as well as for making high frequency switch mode power supplies. Present paper discusses some of the advanced devices/technologies in this field as well as their capability to make advanced/compact/reliable accelerators. Microwave systems developed/under development at Centre for Advanced Technology are also discussed briefly along with some of the efforts done to make them compact. An overview of state of art vacuum tube devices and solid state switch technologies is given. (author)

[Hydatidosis simulating a cardiac tumour with pulmonary metastases].

Science.gov (United States)

Martín-Izquierdo, Marta; Martín-Trenor, Alejandro

2016-01-01

The presence of multiple symptomatic pulmonary nodules and one cardiac tumour in a child requires urgent diagnosis and treatment. Until a few decades ago, the diagnosis of a cardiac tumour was difficult and was based on a high index of suspicion from indirect signs, and required angiocardiography for confirmation. Echocardiography and other imaging techniques have also helped in the detection of cardiac neoplasms. However, it is not always easy to make the correct diagnosis. The case is presented of a 12 year-old boy with pulmonary symptoms, and diagnosed with a cardiac tumour with lung metastases. The presence of numerous pulmonary nodules was confirmed in our hospital. The echocardiogram detected a solid cardiac nodule in the right ventricle. Magnetic resonance imaging confirmed the findings and the diagnosis. Puncture-aspiration of a lung nodule gave the diagnosis of hydatidosis. He underwent open-heart surgery with cardiac cyst resection and treated with anthelmintics. The lung cysts were then excised, and he recovered uneventfully. This child had multiple pulmonary nodules and a solid cardiac nodule, and was suspected of having a cardiac tumour with pulmonary metastases. However, given the clinical history, background and morphology of pulmonary nodules, another possible aetiology for consideration is echinococcosis. The clinical picture of cardiac hydatidosis and its complications is highly variable. The clinical history is essential in these cases, as well as having a high index of suspicion. Hydatidosis should be included in the differential diagnosis of a solid, echogenic, cardiac nodule. The treatment for cardiopulmonary hydatid cysts is surgical, followed by anthelmintics. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

Linear induction accelerators

International Nuclear Information System (INIS)

Briggs, R.J.

1986-06-01

The development of linear induction accelerators has been motivated by applications requiring high-pulsed currents of charged particles at voltages exceeding the capability of single-stage, diode-type accelerators and at currents too high for rf accelerators. In principle, one can accelerate charged particles to arbitrarily high voltages using a multi-stage induction machine, but the 50-MeV, 10-kA Advanced Test Accelerator (ATA) at LLNL is the highest voltage machine in existence at this time. The advent of magnetic pulse power systems makes sustained operation at high-repetition rates practical, and this capability for high-average power is very likely to open up many new applications of induction machines in the future. This paper surveys the US induction linac technology with primary emphasis on electron machines. A simplified description of how induction machines couple energy to the electron beam is given, to illustrate many of the general issues that bound the design space of induction linacs

Imaging in cardiac mass lesions

International Nuclear Information System (INIS)

Mundinger, A.; Gruber, H.P.; Dinkel, E.; Geibel, A.; Beck, A.; Wimmer, B.; Schlosser, V.

1992-01-01

In 26 patients with cardiac mass lesions confirmed by surgery, diagnostic imaging was performed preoperatively by means of two-dimensional echocardiography (26 patients), angiography (12 patients), correlative computed tomography (CT, 8 patients), and magnetic resonance imaging (MRI, 3 patients). Two-dimensional echocardiography correctly identified the cardiac masses in all patients. Angiography missed two of 12 cardiac masses; CT missed one of eight. MRI identified three of three cardiac masses. Although the sensitivity of two-dimensional echocardiography was high (100%), all methods lacked specificity. None of the methods allowed differentiation between myxoma (n=13) and thrombus (n=7). Malignancy of the lesions was successfully predicted by noninvasive imaging methods in all six patients. However, CT and MRI provided additional information concerning cardiac mural infiltration, pericardial involvement, and extracardiac tumor extension, and should be integrated within a preoperative imaging strategy. Thus two-dimensional echocardiography is the method of choice for primary assessment of patients with suspected cardiac masses. Further preoperative imaging by CT or MRI can be limited to patients with malignancies suspected on the grounds of pericardial effusion or other clinical results. (author)

Annotated bibliography on high-intensity linear accelerators. [240 citations

Energy Technology Data Exchange (ETDEWEB)

Jameson, R.A.; Roybal, E.U.

1978-01-01

A technical bibliography covering subjects important to the design of high-intensity beam transport systems and linear accelerators is presented. Space charge and emittance growth are stressed. Subject and author concordances provide cross-reference to detailed citations, which include an abstract and notes on the material. The bibliography resides in a computer database that can be searched for key words and phrases.

Proceedings of the third ICFA mini-workshop on high intensity, high brightness hadron accelerators

International Nuclear Information System (INIS)

Roser, T.

1997-01-01

The third mini-workshop on high intensity, high brightness hadron accelerators was held at Brookhaven National Laboratory on May 7-9, 1997 and had about 30 participants. The workshop focussed on rf and longitudinal dynamics issues relevant to intense and/or bright hadron synchrotrons. A plenary session was followed by four sessions on particular topics. This document contains copies of the viewgraphs used as well as summaries written by the session chairs

Halogenated anaesthetics and cardiac protection in cardiac and non-cardiac anaesthesia

Directory of Open Access Journals (Sweden)

Landoni Giovanni

2009-01-01

Full Text Available Volatile anaesthetic agents have direct protective properties against ischemic myocardial damage. The implementation of these properties during clinical anaesthesia can provide an additional tool in the treatment or prevention, or both, of ischemic cardiac dysfunction in the perioperative period. A recent meta-analysis showed that desflurane and sevoflurane reduce postoperative mortality and incidence of myocardial infarction following cardiac surgery, with significant advantages in terms of postoperative cardiac troponin release, need for inotrope support, time on mechanical ventilation, intensive care unit and overall hospital stay. Multicentre, randomised clinical trials had previously demonstrated that the use of desflurane can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalisation following coronary artery bypass graft surgery either with and without cardiopulmonary bypass. The American College of Cardiology/American Heart Association Guidelines recommend volatile anaesthetic agents during non-cardiac surgery for the maintenance of general anaesthesia in patients at risk for myocardial infarction. Nonetheless, e vidence in non-coronary surgical settings is contradictory and will be reviewed in this paper together with the mechanisms of cardiac protection by volatile agents.

Energy dissipation on ion-accelerator grids during high-voltage breakdown

International Nuclear Information System (INIS)

Menon, M.M.; Ponte, N.S.

1981-01-01

The effects of stored energy in the system capacitance across the accelerator grids during high voltage vacuum breakdown are examined. Measurements were made of the current flow and the energy deposition on the grids during breakdown. It is shown that only a portion (less than or equal to 40 J) of the total stored energy (congruent to 100 J) is actually dissipated on the grids. Most of the energy is released during the formation phase of the vacuum arc and is deposited primarily on the most positive grid. Certain abnormal situations led to energy depositions of about 200 J on the grid, but the ion accelerator endured them without exhibiting any deterioration in performance

JAERI 20 MV tandem accelerator

International Nuclear Information System (INIS)

Tsukada, Kineo; Harada, Kichinosuke

1977-01-01

Accelerators have been developed as the experimental apparatuses for the studies on nuclei and elementary particles. One direction of the development is the acceleration of protons and electrons to more and more high energy, and another direction is the acceleration of heavy ions up to uranium to several MeV up to several hundreds MeV. However recently, accelerators are used as the useful tools for the studies in wider fields. There are electrostatic acceleration and high frequency acceleration in ion acceleration, and at present, super-large accelerators are high frequency acceleration type. In Japan Atomic Energy Research Institute, it was decided in 1975 to construct an electrostatic accelerator of tandem type in order to accelerate heavy ions. In case of the electrostatic acceleration, the construction is relatively simple, the acceleration of heavy ions is easy, the property of the ion beam is very good, and the energy is stable. Especially, the tandem type is convenient for obtaining high energy. The tandem accelerator of 20 MV terminal voltage was ordered from the National Electrostatics Corp., USA, and is expected to be completed in 1978. The significance of heavy ion acceleration in the development and research of atomic energy, tandem van de Graaff accelerators, the JAERI 20MV tandem accelerator, and the research project with this accelerator are described. (Kako, I.)

Design of a high average-power FEL driven by an existing 20 MV electrostatic-accelerator

Energy Technology Data Exchange (ETDEWEB)

Kimel, I.; Elias, L.R. [Univ. of Central Florida, Orlando, FL (United States)

1995-12-31

There are some important applications where high average-power radiation is required. Two examples are industrial machining and space power-beaming. Unfortunately, up to date no FEL has been able to show more than 10 Watts of average power. To remedy this situation we started a program geared towards the development of high average-power FELs. As a first step we are building in our CREOL laboratory, a compact FEL which will generate close to 1 kW in CW operation. As the next step we are also engaged in the design of a much higher average-power system based on a 20 MV electrostatic accelerator. This FEL will be capable of operating CW with a power output of 60 kW. The idea is to perform a high power demonstration using the existing 20 MV electrostatic accelerator at the Tandar facility in Buenos Aires. This machine has been dedicated to accelerate heavy ions for experiments and applications in nuclear and atomic physics. The necessary adaptations required to utilize the machine to accelerate electrons will be described. An important aspect of the design of the 20 MV system, is the electron beam optics through almost 30 meters of accelerating and decelerating tubes as well as the undulator. Of equal importance is a careful design of the long resonator with mirrors able to withstand high power loading with proper heat dissipation features.

Experimental results in superconducting niobium resonators for high-brightness ion beam acceleration

International Nuclear Information System (INIS)

Delayen, J.R.; Bohn, C.L.; Roche, C.T.

1991-01-01

Two niobium resonant cavities for high-brightness ion beam acceleration have been constructed and tested. The first was based on a coaxial quarter-wave geometry and was optimized for phase velocity β O = O.15. This cavity, which resonates at 400 MHz in the fundamental mode, operated at an average (wall-to-wall) accelerating gradient of 12.9 MV/m under continuous-wave (cw) fields. At this gradient, a cavity Q of 1.4x10 8 was measured. The second was based on a coaxial half-wave geometry and was optimized for β O = 0.12. This cavity, which resonates at 355 MHz in the fundamental mode, operated at an average accelerating gradient of 18.0 MV/m under cw fields. This is the highest average accelerating gradient achieved to date in low-velocity structures designed for cw operation. At this gradient, a cavity Q of 1.2 x 10 8 was measured

High gradient RF test results of S-band and C-band cavities for medical linear accelerators

Science.gov (United States)

Degiovanni, A.; Bonomi, R.; Garlasché, M.; Verdú-Andrés, S.; Wegner, R.; Amaldi, U.

2018-05-01

TERA Foundation has proposed and designed hadrontherapy facilities based on novel linacs, i.e. high gradient linacs which accelerate either protons or light ions. The overall length of the linac, and therefore its cost, is almost inversely proportional to the average accelerating gradient. With the scope of studying the limiting factors for high gradient operation and to optimize the linac design, TERA, in collaboration with the CLIC Structure Development Group, has conducted a series of high gradient experiments. The main goals were to study the high gradient behavior and to evaluate the maximum gradient reached in 3 and 5.7 GHz structures to direct the design of medical accelerators based on high gradient linacs. This paper summarizes the results of the high power tests of 3.0 and 5.7 GHz single-cell cavities.

Cardiac Hypertrophy and Brain Natriuretic Peptide Levels in an Ovariectomized Rat Model Fed a High-Fat Diet

Science.gov (United States)

Goncalves, Gleisy Kelly; de Oliveira, Thiago Henrique Caldeira; de Oliveira Belo, Najara

2017-01-01

Background Heart failure in women increases around the time of menopause when high-fat diets may result in obesity. The heart produces brain natriuretic peptide (BNP), also known as B-type natriuretic peptide. This aims of this study were to assess cardiac hypertrophy and BNP levels in ovariectomized rats fed a high-fat diet. Material/Methods Forty-eight female Wistar rats were divided into four groups: sham-operated rats fed a control diet (SC) (n=12); ovariectomized rats fed a control diet (OC) (n=12); sham-operated rats fed a high-fat diet (SF) (n=12); and ovariectomized rats fed a high-fat diet (OF) (n=12). Body weight and blood pressure were measured weekly for 24 weeks. Rats were then euthanized, and plasma samples and heart tissue were studied for gene expression, hydroxyproline levels, and histological examination. Results A high-fat diet and ovariectomy (group OF) increased the weight body and the systolic blood pressure after three months and five months, respectively. Cardiomyocyte hypertrophy was associated with increased expression of ventricular BNP, decreased natriuretic peptide receptor (NPR)-A and increased levels of hydroxyproline and transforming growth factor (TGF)-β. The plasma levels of BNP and estradiol were inversely correlated; expression of estrogen receptor (ER)β and ERα were reduced. Conclusions The findings of this study showed that, in the ovariectomized rats fed a high-fat diet, the BNP-NPR-A receptor complex was involved in cardiac remodeling. BNP may be a marker of cardiac hypertrophy in this animal model. PMID:29249795

DSP accelerator for the wavelet compression/decompression of high- resolution images

Energy Technology Data Exchange (ETDEWEB)

Hunt, M.A.; Gleason, S.S.; Jatko, W.B.

1993-07-23

A Texas Instruments (TI) TMS320C30-based S-Bus digital signal processing (DSP) module was used to accelerate a wavelet-based compression and decompression algorithm applied to high-resolution fingerprint images. The law enforcement community, together with the National Institute of Standards and Technology (NISI), is adopting a standard based on the wavelet transform for the compression, transmission, and decompression of scanned fingerprint images. A two-dimensional wavelet transform of the input image is computed. Then spatial/frequency regions are automatically analyzed for information content and quantized for subsequent Huffman encoding. Compression ratios range from 10:1 to 30:1 while maintaining the level of image quality necessary for identification. Several prototype systems were developed using SUN SPARCstation 2 with a 1280 {times} 1024 8-bit display, 64-Mbyte random access memory (RAM), Tiber distributed data interface (FDDI), and Spirit-30 S-Bus DSP-accelerators from Sonitech. The final implementation of the DSP-accelerated algorithm performed the compression or decompression operation in 3.5 s per print. Further increases in system throughput were obtained by adding several DSP accelerators operating in parallel.

Plasma based charged-particle accelerators

International Nuclear Information System (INIS)

Bingham, R; Mendonca, J T; Shukla, P K

2004-01-01

Studies of charged-particle acceleration processes remain one of the most important areas of research in laboratory, space and astrophysical plasmas. In this paper, we present the underlying physics and the present status of high gradient and high energy plasma accelerators. We will focus on the acceleration of charged particles to relativistic energies by plasma waves that are created by intense laser and particle beams. The generation of relativistic plasma waves by intense lasers or electron beams in plasmas is important in the quest for producing ultra-high acceleration gradients for accelerators. With the development of compact short pulse high brightness lasers and electron positron beams, new areas of studies for laser/particle beam-matter interactions is opening up. A number of methods are being pursued vigorously to achieve ultra-high acceleration gradients. These include the plasma beat wave accelerator mechanism, which uses conventional long pulse (∼100 ps) modest intensity lasers (I ∼ 10 14 -10 16 W cm -2 ), the laser wakefield accelerator (LWFA), which uses the new breed of compact high brightness lasers ( 10 18 W cm -2 , the self-modulated LWFA concept, which combines elements of stimulated Raman forward scattering, and electron acceleration by nonlinear plasma waves excited by relativistic electron and positron bunches. In the ultra-high intensity regime, laser/particle beam-plasma interactions are highly nonlinear and relativistic, leading to new phenomena such as the plasma wakefield excitation for particle acceleration, relativistic self-focusing and guiding of laser beams, high-harmonic generation, acceleration of electrons, positrons, protons and photons. Fields greater than 1 GV cm -1 have been generated with particles being accelerated to 200 MeV over a distance of millimetre. Plasma wakefields driven by positron beams at the Stanford Linear Accelerator Center facility have accelerated the tail of the positron beam. In the near future

Beam transport through electrostatic accelerators and matching into post accelerators

International Nuclear Information System (INIS)

Larson, J.D.

1986-01-01

Ion beam transport through electrostatic acceleration is briefly reviewed. Topics discussed include injection, matching into the low-energy acceleration stage, matching from the terminal stripper into the high-energy stage, transport to a post accelerator, space charge, bunching isochronism, dispersion and charge selection. Beam transport plans for the proposed Vivitron accelerator are described. (orig.)

Prognostic Value of High-Sensitivity Cardiac Troponin T Compared with Risk Scores in Stable Cardiovascular Disease.

Science.gov (United States)

Biener, Moritz; Giannitsis, Evangelos; Kuhner, Manuel; Zelniker, Thomas; Mueller-Hennessen, Matthias; Vafaie, Mehrshad; Trenk, Dietmar; Neumann, Franz-Josef; Hochholzer, Willibald; Katus, Hugo A

2017-05-01

Risk stratification of patients with cardiovascular disease remains challenging despite consideration of risk scores. We aimed to evaluate the prognostic performance of high-sensitivity cardiac troponin T in a low-risk outpatient population presenting for nonsecondary and secondary prevention. All-cause mortality, a composite of all-cause mortality, acute myocardial infarction, and stroke (end point 2), and a composite of all-cause mortality, acute myocardial infarction, stroke and rehospitalization for acute coronary syndrome, and decompensated heart failure (end point 3) were defined. The prognostic performance of high-sensitivity cardiac troponin T on index visit was compared with the PROCAM score and 3 FRAMINGHAM subscores. In 693 patients with a median follow-up of 796 days, we observed 16 deaths, 32 patients with end point 2, and 83 patients with end point 3. All risk scores performed better in the prediction of all-cause mortality in nonsecondary prevention (area under the curve [AUC]: PROCAM: 0.922 vs 0.523, P = .001, consistent for all other scores). In secondary prevention, high-sensitivity cardiac troponin T outperformed all risk scores in the prediction of all-cause mortality (ΔAUC: PROCAM: 0.319, P risk scores. Our findings on the prediction of all-cause mortality compared with the FRAMINGHAM-Hard Coronary Heart Disease score were confirmed in an independent validation cohort on 2046 patients. High-sensitivity troponin T provides excellent risk stratification regarding all-cause mortality and all-cause mortality, acute myocardial infarction, and stroke in a secondary prevention cohort in whom risk scores perform poorly. Copyright © 2016 Elsevier Inc. All rights reserved.

A practical guide to modern high energy particle accelerators

International Nuclear Information System (INIS)

Holmes, S.D.

1987-10-01

The purpose of these lectures is to convey an understanding of how particle accelerators work and why they look the way they do. The approach taken is physically intuitive rather than mathematically rigorous. The emphasis is on the description of proton circular accelerators and colliders. Linear accelerators are mentioned only in passing as sources of protons for higher energy rings. Electron accelerators/storage rings and antiproton sources are discussed only by way of brief descriptions of the features which distinguish them from proton accelerators. The basics of how generic accelerators work are discussed, focusing on descriptions of what sets the overall scale, single particle dynamics and stability, and descriptions of the phase space of the particle beam, the information thus presented is then used to go through the exercise of designing a Superconducting Super Collider

High gradient experiment by accelerator test facility for Japan Linear Collider