WorldWideScience

Sample records for higher load factor

  1. Intelligence Tests with Higher G-Loadings Show Higher Correlations with Body Symmetry: Evidence for a General Fitness Factor Mediated by Developmental Stability

    Science.gov (United States)

    Prokosch, M.D.; Yeo, R.A.; Miller, G.F.

    2005-01-01

    Just as body symmetry reveals developmental stability at the morphological level, general intelligence may reveal developmental stability at the level of brain development and cognitive functioning. These two forms of developmental stability may overlap by tapping into a ''general fitness factor.'' If so, then intellectual tests with higher…

  2. Dynamical load factor of impact loaded shell structures

    International Nuclear Information System (INIS)

    Hammel, J.

    1977-01-01

    Dynamical loaded structures can be analysed by spectral representations, which usually lead to an enormous computational effort. If it is possible to find a fitting dynamical load factor, the dynamical problem can be reduced to a statical one. The computation of this statical problem is much simpler. The disadvantage is that the dynamical load factor usually leads to a very rough approximation. In this paper it will be shown, that by combination of these two methods, the approximation of the dynamical load factor can be improved and the consumption of computation time can be enormously reduced. (Auth.)

  3. Consideration of higher seismic loads at existing plants

    Energy Technology Data Exchange (ETDEWEB)

    Liebig, J.; Pellissetti, M.

    2015-07-01

    Because of advancement of methods in probabilistic seismic hazard analysis, plenty of existing plants face higher seismic loads as an obligation from the national authorities. In case of such obligations safety related structures and equipment have to be reevaluated or requalified for the increased seismic loads. The paper provides solutions for different kinds of structures and equipment inside the plant, avoiding cost intensive hardware exchange. Due to higher seismic loads different kinds of structures and equipment inside a plant have to be reevaluated. For civil structures, primary components, mechanical components, distribution lines and electrical and I&C equipment different innovative concepts will be applied to keep structures and equipment qualified for the higher seismic loads. Detailed analysis, including the modeling of non-linear phenomena, or minor structural upgrades are cost competitive, compared to cost intensive hardware exchanges. Several case studies regarding the re-evaluation and requalification of structures and equipment due to higher seismic loads are presented. It is shown how the creation of coupled finite element models and the consistent propagation of acceleration time histories through the soil, building and primary circuit lead to a significant load reduction Electrical and I&C equipment is reinforced by smart upgrades which increase the natural equipment frequencies. Therefore for all devices inside the cabinets the local acceleration will not increase and the seismic qualification will be maintained. The case studies cover both classical deterministic and probabilistic re-evaluations (fragility analysis). Furthermore, the substantial benefits of non-linear limit load evaluation, such as push-over analysis of buildings and limit load analysis of fuel assemblies, are demonstrated. (Author)

  4. Load factors to end March 1989

    International Nuclear Information System (INIS)

    Howles, L.

    1989-01-01

    Load factors for nuclear reactors of 150MWe gross and above for the 12 month period up to the end of March 1989, and over their lifetimes, are tabulated. Units which have been in operation for more than one year as of end March 1989 are ranked in order of annual load factor; cumulative load factors are also shown, measured from first synchronization to the grid not from start of commercial operation. New reactors which had operated for less than 12 months as of end of March 1989 are listed separately. With the exception of the four Paks units in Hungary, Comecon reactors are excluded due to lack of data. (author)

  5. Factor structure underlying components of allostatic load.

    Directory of Open Access Journals (Sweden)

    Jeanne M McCaffery

    Full Text Available Allostatic load is a commonly used metric of health risk based on the hypothesis that recurrent exposure to environmental demands (e.g., stress engenders a progressive dysregulation of multiple physiological systems. Prominent indicators of response to environmental challenges, such as stress-related hormones, sympatho-vagal balance, or inflammatory cytokines, comprise primary allostatic mediators. Secondary mediators reflect ensuing biological alterations that accumulate over time and confer risk for clinical disease but overlap substantially with a second metric of health risk, the metabolic syndrome. Whether allostatic load mediators covary and thus warrant treatment as a unitary construct remains to be established and, in particular, the relation of allostatic load parameters to the metabolic syndrome requires elucidation. Here, we employ confirmatory factor analysis to test: 1 whether a single common factor underlies variation in physiological systems associated with allostatic load; and 2 whether allostatic load parameters continue to load on a single common factor if a second factor representing the metabolic syndrome is also modeled. Participants were 645 adults from Allegheny County, PA (30-54 years old, 82% non-Hispanic white, 52% female who were free of confounding medications. Model fitting supported a single, second-order factor underlying variance in the allostatic load components available in this study (metabolic, inflammatory and vagal measures. Further, this common factor reflecting covariation among allostatic load components persisted when a latent factor representing metabolic syndrome facets was conjointly modeled. Overall, this study provides novel evidence that the modeled allostatic load components do share common variance as hypothesized. Moreover, the common variance suggests the existence of statistical coherence above and beyond that attributable to the metabolic syndrome.

  6. 14 CFR 27.337 - Limit maneuvering load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit maneuvering load factor. 27.337... Limit maneuvering load factor. The rotorcraft must be designed for— (a) A limit maneuvering load factor... load factor not less than 2.0 and any negative limit maneuvering load factor of not less than −0.5 for...

  7. 14 CFR 29.337 - Limit maneuvering load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit maneuvering load factor. 29.337... Limit maneuvering load factor. The rotorcraft must be designed for— (a) A limit maneuvering load factor... load factor not less than 2.0 and any negative limit maneuvering load factor of not less than −0.5 for...

  8. 14 CFR 31.23 - Flight load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flight load factor. 31.23 Section 31.23... STANDARDS: MANNED FREE BALLOONS Strength Requirements § 31.23 Flight load factor. In determining limit load, the limit flight load factor must be at least 1.4. ...

  9. Local load-sharing fiber bundle model in higher dimensions.

    Science.gov (United States)

    Sinha, Santanu; Kjellstadli, Jonas T; Hansen, Alex

    2015-08-01

    We consider the local load-sharing fiber bundle model in one to five dimensions. Depending on the breaking threshold distribution of the fibers, there is a transition where the fracture process becomes localized. In the localized phase, the model behaves as the invasion percolation model. The difference between the local load-sharing fiber bundle model and the equal load-sharing fiber bundle model vanishes with increasing dimensionality with the characteristics of a power law.

  10. Elastic form factors at higher CEBAF energies

    Energy Technology Data Exchange (ETDEWEB)

    Petratos, G.G. [Kent State Univ., OH (United States)

    1994-04-01

    The prospects for elastic scattering from few body systems with higher beam energies at CEBAF is presented. The deuteron and{sup 3}He elastic structure functions A(Q{sup 2}) can be measured at sufficiently high momentum transfers to study the transition between the conventional meson-nucleon and the constituent quark-gluon descriptions. Possible improvements in the proton magnetic form factor data are also presented.

  11. Conservative flight with a varying load factor and closed form ...

    Indian Academy of Sciences (India)

    Conservative flight performance of an aircraft with constant load factor was analysed by ... Within the frame work of flat earth hypotheses the equations of motion of an aircraft as obtained by ..... load factor function if this inequality holds good.

  12. 14 CFR 398.9 - Load factor standards.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Load factor standards. 398.9 Section 398.9... STATEMENTS GUIDELINES FOR INDIVIDUAL DETERMINATIONS OF BASIC ESSENTIAL AIR SERVICE § 398.9 Load factor standards. The load factor standards used in this part may be raised for individual eligible places under...

  13. Probability based load factors for design of concrete containment structures

    International Nuclear Information System (INIS)

    Hwang, H.; Kagami, S.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper describes a procedure for developing probability-based load combinations for the design of concrete containments. The proposed criteria are in a load and resistance factor design (LRFD) format. The load factors and resistance factors are derived for use in limit states design and are based on a target limit state probability. In this paper, the load factors for accident pressure and safe shutdown earthquake are derived for three target limit state probabilities. Other load factors are recommended on the basis of prior experience with probability-based design criteria for ordinary building construction. 6 refs

  14. Response of inherently brittle materials on higher loading rates

    Czech Academy of Sciences Publication Activity Database

    Chlup, Zdeněk; Flašar, Petr; Dlouhý, Ivo

    2010-01-01

    Roč. 77, č. 2 (2010), s. 359-366 ISSN 0013-7944 R&D Projects: GA ČR GA101/09/1821; GA AV ČR IAA200410502 Institutional research plan: CEZ:AV0Z20410507 Keywords : Dynamic fracture toughness * Stress intensity factor * Ceramics Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 1.571, year: 2010

  15. Testing for time-varying loadings in dynamic factor models

    DEFF Research Database (Denmark)

    Mikkelsen, Jakob Guldbæk

    Abstract: In this paper we develop a test for time-varying factor loadings in factor models. The test is simple to compute and is constructed from estimated factors and residuals using the principal components estimator. The hypothesis is tested by regressing the squared residuals on the squared...... there is evidence of time-varying loadings on the risk factors underlying portfolio returns for around 80% of the portfolios....

  16. Load factor trends in light water reactor units

    International Nuclear Information System (INIS)

    Lehtinen, E.A.

    1990-01-01

    The Technical Research Centre of Finland follows up and analyses nuclear power plant availability performances worldwide. The results of a trend study for the load factors of the LWR units have been updated to the end of 1987. The whole operating history, in the sense of the annual and cumulative load factors achieved by all the Western commercial LWR units until the end of 1987, has been taken into consideration. Some trends in the load factors have been identified by using an exponential regression model developed. The LWR units form quite an inhomogeneous population with respect to their age, technical characteristics, site country as well as cumulative load factors achieved. The cumulative load factors achieved by all the LWR units until the end of 1987 are presented individually in the scattergrams

  17. Impact of measurement uncertainty from experimental load distribution factors on bridge load rating

    Science.gov (United States)

    Gangone, Michael V.; Whelan, Matthew J.

    2018-03-01

    Load rating and testing of highway bridges is important in determining the capacity of the structure. Experimental load rating utilizes strain transducers placed at critical locations of the superstructure to measure normal strains. These strains are then used in computing diagnostic performance measures (neutral axis of bending, load distribution factor) and ultimately a load rating. However, it has been shown that experimentally obtained strain measurements contain uncertainties associated with the accuracy and precision of the sensor and sensing system. These uncertainties propagate through to the diagnostic indicators that in turn transmit into the load rating calculation. This paper will analyze the effect that measurement uncertainties have on the experimental load rating results of a 3 span multi-girder/stringer steel and concrete bridge. The focus of this paper will be limited to the uncertainty associated with the experimental distribution factor estimate. For the testing discussed, strain readings were gathered at the midspan of each span of both exterior girders and the center girder. Test vehicles of known weight were positioned at specified locations on each span to generate maximum strain response for each of the five girders. The strain uncertainties were used in conjunction with a propagation formula developed by the authors to determine the standard uncertainty in the distribution factor estimates. This distribution factor uncertainty is then introduced into the load rating computation to determine the possible range of the load rating. The results show the importance of understanding measurement uncertainty in experimental load testing.

  18. Perceptual load corresponds with factors known to influence visual search.

    Science.gov (United States)

    Roper, Zachary J J; Cosman, Joshua D; Vecera, Shaun P

    2013-10-01

    One account of the early versus late selection debate in attention proposes that perceptual load determines the locus of selection. Attention selects stimuli at a late processing level under low-load conditions but selects stimuli at an early level under high-load conditions. Despite the successes of perceptual load theory, a noncircular definition of perceptual load remains elusive. We investigated the factors that influence perceptual load by using manipulations that have been studied extensively in visual search, namely target-distractor similarity and distractor-distractor similarity. Consistent with previous work, search was most efficient when targets and distractors were dissimilar and the displays contained homogeneous distractors; search became less efficient when target-distractor similarity increased irrespective of display heterogeneity. Importantly, we used these same stimuli in a typical perceptual load task that measured attentional spillover to a task-irrelevant flanker. We found a strong correspondence between search efficiency and perceptual load; stimuli that generated efficient searches produced flanker interference effects, suggesting that such displays involved low perceptual load. Flanker interference effects were reduced in displays that produced less efficient searches. Furthermore, our results demonstrate that search difficulty, as measured by search intercept, has little bearing on perceptual load. We conclude that rather than be arbitrarily defined, perceptual load might be defined by well-characterized, continuous factors that influence visual search. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  19. An alternative method for centrifugal compressor loading factor modelling

    Science.gov (United States)

    Galerkin, Y.; Drozdov, A.; Rekstin, A.; Soldatova, K.

    2017-08-01

    The loading factor at design point is calculated by one or other empirical formula in classical design methods. Performance modelling as a whole is out of consideration. Test data of compressor stages demonstrates that loading factor versus flow coefficient at the impeller exit has a linear character independent of compressibility. Known Universal Modelling Method exploits this fact. Two points define the function - loading factor at design point and at zero flow rate. The proper formulae include empirical coefficients. A good modelling result is possible if the choice of coefficients is based on experience and close analogs. Earlier Y. Galerkin and K. Soldatova had proposed to define loading factor performance by the angle of its inclination to the ordinate axis and by the loading factor at zero flow rate. Simple and definite equations with four geometry parameters were proposed for loading factor performance calculated for inviscid flow. The authors of this publication have studied the test performance of thirteen stages of different types. The equations are proposed with universal empirical coefficients. The calculation error lies in the range of plus to minus 1,5%. The alternative model of a loading factor performance modelling is included in new versions of the Universal Modelling Method.

  20. Residential Load Manageability Factor Analyses by Load Sensitivity Affected by Temperature

    Directory of Open Access Journals (Sweden)

    N. Eskandari

    2016-12-01

    Full Text Available Load side management is the basic and significant principle to keeping the balance between generation side and consumption side of electrical power energy. Load side management on typical medium voltage feeder is the power energy consumption control of connected loads with variation of essential parameters that loads do reaction to their variation. Knowing amount of load's reaction to each parameters variation in typical medium voltage feeder during the day, leads to gain Load Manageability Factor (LMF for that specific feeder that helps power utilities to manage their connected loads. Calculating this LMF needs to find out each types of load with unique inherent features behavior to each parameters variation. This paper results and future work results will help us to catch mentioned LMF. In this paper analysis of residential load behavior due to temperature variation with training artificial neural network will be done. Load behavior due to other essential parameters variations like energy pricing variation, major event happening, and power utility announcing to the customers, and etc will study in future works. Collecting all related works results in a unit mathematical equation or an artificial neural network will gain LMF.

  1. Loading factor and inclination parameter of diagonal type MHD generators

    International Nuclear Information System (INIS)

    Ishikawa, Motoo

    1979-01-01

    Regarding diagonal type MHD generators is studied the relation between the loading factor and inclination parameter which is required for attaining the maximum power density with a given electrical efficiency on the assumption of infinitely segmented electrodes. The average current density on electrodes is calculated against the Hall parameter, loading factor, and inclination parameter. The diagonal type generator is compared with Faraday type generator regarding the average current density. Decreasing the loading factor from inlet to outlet is appropriate to small size generators but increasing to large size generators. The inclination parameter had better decrease in both generators, being smaller for small generators than for large ones. The average current density on electrodes of diagonal type generators varies less with the loading factor than the Faraday type. In large size generators its value can become smaller compared with that of the Faraday type. (author)

  2. Load Distribution Factors for Composite Multicell Box Girder Bridges

    Science.gov (United States)

    Tiwari, Sanjay; Bhargava, Pradeep

    2017-12-01

    Cellular steel section composite with a concrete deck is one of the most suitable superstructures in resisting torsional and warping effects induced by highway loading. This type of structure has inherently created new design problems for engineers in estimating its load distribution when subjected to moving vehicles. Indian Codes of Practice does not provide any specific guidelines for the design of straight composite concrete deck-steel multi-cell bridges. To meet the practical requirements arising during the design process, a simple design method is needed for straight composite multi-cell bridges in the form of load distribution factors for moment and shear. This work presents load distribution characteristics of straight composite multi-cell box girder bridges under IRC trains of loads.

  3. Experimental study on the potential of higher octane number fuels for low load partially premixed combustion

    NARCIS (Netherlands)

    Wang, S.; van der Waart, K.; Somers, B.; de Goey, P.

    2017-01-01

    The optimal fuel for partially premixed combustion (PPC) is considered to be a gasoline boiling range fuel with an octane number around 70. Higher octane number fuels are considered problematic with low load and idle conditions. In previous studies mostly the intake air temperature did not exceed 30

  4. Higher harmonic imaging of tensile plastic deformation in loading and reloading processes by local resonance method

    International Nuclear Information System (INIS)

    Kawashima, Koichiro; Yasui, Hajime

    2015-01-01

    We have imaged plastically deformed region in a 5052 aluminum plate under tensile loading, unloading and reloading processes by using an immersion local resonance method. By transmitting large-amplitude burst wave of which frequency is a through-thickness resonant frequency of the plate, dislocation loops in plastic zone are forced to vibrate. The higher harmonic amplitude excited by the dislocation movement is mapped for the transducer position. The extension of plastic zone under monotonically increased loading, decrease in harmonic amplitude under unloading process and marked extension of plastic zone in reloading up to 0.4% plastic strain are clearly imaged. (author)

  5. Means of achieving high load factors at Olkiluoto 1 and 2

    International Nuclear Information System (INIS)

    Patrakka, E.

    2001-01-01

    Teollisuuden Voima Oy operates two BWR units Olkiluoto 1 and 2 that have achieved load factors typically higher than 90%. The operating experiences gained in the 1990s is summarised and the factors contributing to the high capacity factors are addressed. These include the general objectives for operation and maintenance, plant modernisation programme, maintenance principles, and outage policy and experiences. Finally, the international evaluations performed at Olkiluoto are mentioned. (author)

  6. EFFECT OF FLIPPED LEARNING ON COGNITIVE LOAD: A HIGHER EDUCATION RESEARCH

    Directory of Open Access Journals (Sweden)

    Celal Karaca

    2017-01-01

    Full Text Available The purpose of this study is to determine the effect of the flipped learning method on the cognitive load of the students. The study was conducted with a sample of 160 people who were trained in Department of Mechanical Engineering for algorithms and programming courses at a higher education level. The study, which lasted for 8 weeks, has a semi-experimental design. A 9-point scale developed by Paas and Van Merrienboer (1993 was used for cognitive load measurements. At the end of the weekly courses, the scale was filled by the experimental and control groups. Independent sample t test was applied through SPSS 24 program to the obtained data. In both instances, the cognitive load in the experimental group in which the flipped learning method was applied was found to be lower than the cognitive load in the control group in which traditional face-to-face training was applied. As a result, it can be said that flipped learning, if well structured, is a method reducing cognitive load.

  7. Reducing Undue Conservatism in "Higher Frequency" Structural Design Loads in Aerospace Components

    Science.gov (United States)

    Knight, J. Brent

    2012-01-01

    This study is intended to investigate the frequency dependency of significant strain due to vibratory loads in aerospace vehicle components. The notion that "higher frequency" dynamic loads applied as static loads is inherently conservative is perceived as widely accepted. This effort is focused on demonstrating that principle and attempting to evolve methods to capitalize on it to mitigate undue conservatism. It has been suggested that observations of higher frequency modes that resulted in very low corresponding strain did so due to those modes not being significant. Two avionics boxes, one with its first significant mode at 341 Hz and the other at 857 Hz, were attached to a flat panel installed on a curved orthogrid panel which was driven acoustically in tests performed at NASA/MSFC. Strain and acceleration were measured at select locations on each of the boxes. When possible, strain gage rosettes and accelerometers were installed on either side of a given structural member so that measured strain and acceleration data would directly correspond to one another. Ultimately, a frequency above which vibratory loads can be disregarded for purposes of static structural analyses and sizing of typical robust aerospace components is sought.

  8. Factors affecting the adoption and diffusion of Internet in higher ...

    African Journals Online (AJOL)

    Journal of Language, Technology & Entrepreneurship in Africa ... Factors affecting the adoption and diffusion of Internet in higher educational institutions in Kenya ... communication Technologies (ICTs) such as the Internet, Learning ...

  9. RIP INPUT TABLES FROM WAPDEG FOR LA DESIGN SELECTION: HIGHER THERMAL LOADING

    International Nuclear Information System (INIS)

    K. Mon

    1999-01-01

    The purpose of this calculation is to document (1) the Waste Package Degradation (WAPDEG) version 3.09 (CRWMS M and O 1998b. Software Routine Report for WAPDEG (Version 3.09)) simulations used to analyze waste package degradation and failure under the repository exposure conditions characterized by the higher thermal loading repository design feature and, (2) post-processing of these results into tables of waste package degradation time histories suitable for use as input into the Integrated Probabilistic Simulator for Environmental Systems version 5.19.01 (RIP) computer program (Golder Associates 1998). Specifically, the WAPDEG simulations discussed in this calculation correspond to waste package emplacement conditions (repository environment and design) defined in the Total System Performance Assessment-Viability Assessment (TSPA-VA), with the exception that the higher thermal loading Design Feature (Design Feature 26) of the License Application Design Selection (LADS) analysis was analyzed. Higher thermal loading would keep the drift temperature above the boiling point of water for a longer period of time, thereby minimizing moisture around the waste packages during a longer post-closure period. The higher thermal loading would also affect the surrounding rock, which may have adverse effects. The only failure mechanism of this feature would be if the effects on the surrounding rock were determined to be unacceptable. As a result of the change in waste package placement relative to the TSPA-VA base-case design, different temperature and relative humidity time histories at the waste package surface are calculated (input to the WAPDEG simulations), and consequently different waste package failure histories (as calculated by WAPDEG) result

  10. 14 CFR 23.527 - Hull and main float load factors.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull and main float load factors. 23.527... Water Loads § 23.527 Hull and main float load factors. (a) Water reaction load factors nw must be...=seaplane landing weight in pounds. (6) K1=empirical hull station weighing factor, in accordance with figure...

  11. Reliability-based load and resistance factor design for piping: an exploratory case study

    International Nuclear Information System (INIS)

    Gupta, Abhinav; Choi, Byounghoan

    2003-01-01

    This paper presents an exploratory case study on the application of Load and Resistance Factor Design (LRFD) approach to the Section III of ASME Boiler and Pressure Vessel code for piping design. The failure criterion for defining the performance function is considered as plastic instability. Presently used design equation is calibrated by evaluating the minimum reliability levels associated with it. If the target reliability in the LRFD approach is same as that evaluated for the presently used design equation, it is shown that the total safety factors for the two design equations are identical. It is observed that the load and resistance factors are not dependent upon the diameter to thickness ratio. A sensitivity analysis is also conducted to study the variations in the load and resistance factors due to changes in (a) coefficients of variation for pressure, moment, and ultimate stress, (b) ratio of mean design pressure to mean design moment, (c) distribution types used for characterizing the random variables, and (d) statistical correlation between random variables. It is observed that characterization of random variables by log-normal distribution is reasonable. Consideration of statistical correlation between the ultimate stress and section modulus gives higher values of the load factor for pressure but lower value for the moment than the corresponding values obtained by considering the variables to be uncorrelated. Since the effect of statistical correlation on the load and resistance factors is relatively insignificant for target reliability values of practical interest, the effect of correlated variables may be neglected

  12. Higher- and Lower-Order Factor Analyses of the Temperament in Middle Childhood Questionnaire

    Science.gov (United States)

    Kotelnikova, Yuliya; Olino, Thomas M.; Klein, Daniel N.; Mackrell, Sarah V.M.; Hayden, Elizabeth P.

    2017-01-01

    The Temperament in Middle Childhood Questionnaire (TMCQ; Simonds & Rothbart, 2004) is a widely used parent-report measure of temperament. However, neither its lower- nor higher-order structures have been tested via a bottom-up, empirically based approach. We conducted higher- and lower-order exploratory factor analyses (EFAs) of the TMCQ in a large (N = 654) sample of 9-year-olds. Item-level EFAs identified 92 items as suitable (i.e., with loadings ≥.40) for constructing lower-order factors, only half of which resembled a TMCQ scale posited by the measure’s authors. Higher-order EFAs of the lower-order factors showed that a three-factor structure (Impulsivity/Negative Affectivity, Negative Affectivity, and Openness/Assertiveness) was the only admissible solution. Overall, many TMCQ items did not load well onto a lower-order factor. In addition, only three factors, which did not show a clear resemblance to Rothbart’s four-factor model of temperament in middle childhood, were needed to account for the higher-order structure of the TMCQ. PMID:27002124

  13. Influential Factors in Choosing Higher Education Institutions Among Students

    Directory of Open Access Journals (Sweden)

    Zlata Kastelic

    2017-05-01

    Full Text Available Purpose and Originality:The purpose of this article is to determine which factors are influential for students inchoosinga specific higher education institution. Method:By analyzing available literature and existing surveys, we gained in-depthknowledgeof key theoretical conceptsof the researched problem. The latter represents the basis on which we have designed our own research algorithm and conducted a proper survey. The purpose of the research was to analyze, which factors affect the most individuals to enroll in aspecific higher education institution, and to what extent our findings coincide with other studies’ findings. Results:The results showed a significant degree of correlation between factors that motivate foreign students to enrol in a higher education institution. Society:By knowing which areinfluential factors for students’ enrollment in HEIs the latterwill be able to recognize and satisfy needs and desires of potential students and subsequently design attractive studying programmes and thus equip them with knowledge in order to become competent individuals to successfully compete on labour market. Limitations/Future Research: Generalisation of results was limited due to the small size of the sample, and since all respondents came from only one Slovenian region. But since this is the first such surveyit represents a complex and remarkable preliminary study that can be upgradedand generate important contribution in understanding the key factors, which stimultae students for enrollment in higher education institutions.

  14. Metasystem approach to increase the load factor FMS

    Directory of Open Access Journals (Sweden)

    Pishchukhin Alexandr

    2017-01-01

    Full Text Available The work is devoted to increasing the efficiency of using flexible manufacture systems (FMS by increasing the load factor. Unlike the well-known multi-agent approach to production management, we are investigating the addition of a metasystem level allowing flexible combination of the decentralized control method with centralization. The metasystem approach allows to reduce management to flexible switching of functioning technologies on the basis of the replacement rule, while describing FMS as a metasystem consisting of classification of the system analyst J. Klir from structured data systems. Production events are simulated in virtual space with the help of a multi-agent approach. At the same time, the number of requests from the waiting queue is chosen such that it becomes possible to optimize the loading of the FMS in the simplest case by the full-scan method, if the queue is not available, then the initiative of choice is provided to communications of agents-technologies and agents-equipments. Experimental studies were carried out on the FMS model including six pieces of equipment divided into three groups with a stream of six applications, each of which has a technological route of six operations each‥ The experimental results showed the consistency of the developed approach by increasing the load factor of the FMS.

  15. Conflict at Higher Education Institutions: Factors and Solutions for Yemen

    Science.gov (United States)

    Muthanna, Abdulghani; Sang, Guoyuan

    2018-01-01

    This is a qualitative case study focusing on reporting the dynamics that cause conflicts between academics and administrators in higher education in Yemen. Drawing upon a critical review of two policy documents, observational research and in-depth interviews with 59 administrators and academics, the article presents the key factors for conflict in…

  16. Factors Affecting English Language Teaching and Learning in Higher Education

    Science.gov (United States)

    Nguyen, Hong Thi; Warren, Wendy; Fehring, Heather

    2014-01-01

    This paper reports part of a study that aims to explore factors affecting the efficacy of non-major English teaching and learning in Vietnamese higher education through an investigation of classroom practices. Eight non-participant class observations were conducted at HUTECH University, Ho Chi Minh City, Vietnam. The study's findings show that…

  17. Higher School Marketing Strategy Formation: Classifying the Factors

    Directory of Open Access Journals (Sweden)

    N. K. Shemetova

    2012-01-01

    Full Text Available The paper deals with the main trends of higher school management strategy formation. The author specifies the educational changes in the modern information society determining the strategy options. For each professional training level the author denotes the set of strategic factors affecting the educational service consumers and, therefore, the effectiveness of the higher school marketing. The given factors are classified from the stand-points of the providers and consumers of educational service (enrollees, students, graduates and postgraduates. The research methods include the statistic analysis and general methods of scientific analysis, synthesis, induction, deduction, comparison, and classification. The author is convinced that the university management should develop the necessary prerequisites for raising the graduates’ competitiveness in the labor market, and stimulate the active marketing policies of the relating subdivisions and departments. In author’s opinion, the above classification of marketing strategy factors can be used as the system of values for educational service providers. 

  18. Psychosocial risks evaluation factors: study with higher education teachers

    Directory of Open Access Journals (Sweden)

    Sara Lopes Borges

    2018-02-01

    Method: The study consisted of the administration of two instruments, one for the characterization of the sample and the other for assessing psychosocial risk factors — the Copenhagen Psychosocial Questionnaire — consisting of 76 items (5-point Likert scale, distributed in five dimensions, which measure indicators of exposure to psychosocial risks and their effects. Results: The study included 59 teachers, mostly men (50.8%, aged between 41 - 50 years (45.8%, with master's degree (59%, assistant professors (47.5%; with a stable employment relationship (68%, years of service between 14-17 years (18.7% and teaching between 11 - 17 hours a week (64.4%. The analysis of the various subscales revealed a psychosocial risk, showing that teachers are in a situation of vulnerability. There were significant differences between the risks experienced in public higher education and those experienced in private higher education. Gender, age, academic background, and professional category influenced the type of psychosocial risk. Conclusions: The study confirms the importance of the evaluation of psychosocial risk factors in the exercise of the teaching profession in higher education. It is recognized that it is necessary to assess and manage psychosocial risks in order to promote healthy working conditions, ensure respect and fair treatment, and encourage the promotion of work / family life balance, in order to minimize psychosocial risks and situations of vulnerability in higher education teachers.

  19. A study on the load distribution factor in the perforated square plate with elastic support

    International Nuclear Information System (INIS)

    Lee, Y.S.; Yim, J.S.

    1993-01-01

    The load distribution factor in the perforated square plate supporting by angle shape legs under concentrated load acting at arbitrary points through elastic media is calculated. For the calculation the perforated plate was converted into an orthotropic plate using the method suggested by J.B. Mahoney. The deflection for the calculation of the load distribution factor was obtained from the auxiliary plate which was extended both sides of the plate and it was compared with the results from ANSYS calculation. With this deflection, the calculation of the load distribution factor was performed. The result shows that the load distribution factor at the periphery of the plate is larger than that of in the central location. This load distribution factor could be used for re-distribution of the applied load in more accurate analysis of the plate as well as in the analysis of the elastic media as the load factor. (author)

  20. Load and resistance factor design of drilled shafts in shale for lateral loading.

    Science.gov (United States)

    2014-04-01

    A research project involving 32 drilled shaft load tests was undertaken to establish LRFD procedures for : design of drilled shafts subjected to lateral loads. Tests were performed at two Missouri Department of : Transportation (MoDOT) geotechnical r...

  1. Impact Study on Power Factor of Electrical Load in Power Distribution System

    International Nuclear Information System (INIS)

    Syirrazie Che Soh; Harzawardi Hasim; Ahmad Asraf, A.S.

    2014-01-01

    Low Power Factor of electrical loads cause high current is drawn from power supply. The impact of this circumstance is influenced by impedance of electrical load. Therefore, the key consideration of this study is how impedance of electrical loads influence power factor of electrical loads, and then power distribution as the whole. This study is important to evaluate the right action to mitigate low power factor effectively for electrical energy efficiency purpose. (author)

  2. Factors associated with higher oxytocin requirements in labor.

    Science.gov (United States)

    Frey, Heather A; Tuuli, Methodius G; England, Sarah K; Roehl, Kimberly A; Odibo, Anthony O; Macones, George A; Cahill, Alison G

    2015-09-01

    To identify clinical characteristics associated with high maximum oxytocin doses in women who achieve complete cervical dilation. A retrospective nested case-control study was performed within a cohort of all term women at a single center between 2004 and 2008 who reached the second stage of labor. Cases were defined as women who had a maximum oxytocin dose during labor >20 mu/min, while women in the control group had a maximum oxytocin dose during labor of ≤20 mu/min. Exclusion criteria included no oxytocin administration during labor, multiple gestations, major fetal anomalies, nonvertex presentation, and prior cesarean delivery. Multiple maternal, fetal, and labor factors were evaluated with univariable analysis and multivariable logistic regression. Maximum oxytocin doses >20 mu/min were administered to 108 women (3.6%), while 2864 women received doses ≤20 mu/min. Factors associated with higher maximum oxytocin dose after adjusting for relevant confounders included maternal diabetes, birthweight >4000 g, intrapartum fever, administration of magnesium, and induction of labor. Few women who achieve complete cervical dilation require high doses of oxytocin. We identified maternal, fetal and labor factors that characterize this group of parturients.

  3. [Distribution of neural memory, loading factor, its regulation and optimization].

    Science.gov (United States)

    Radchenko, A N

    1999-01-01

    Recording and retrieving functions of the neural memory are simulated as a control of local conformational processes in neural synaptic fields. The localization of conformational changes is related to the afferent temporal-spatial pulse pattern flow, the microstructure of connections and a plurality of temporal delays in synaptic fields and afferent pathways. The loci of conformations are described by sets of afferent addresses named address domains. Being superimposed on each other, address domains form a multilayer covering of the address space of the neuron or the ensemble. The superposition factor determines the dissemination of the conformational process, and the fuzzing of memory, and its accuracy and reliability. The engram is formed as detects in the packing of the address space and hence can be retrieved in inverse form. The accuracy of the retrieved information depends on the threshold level of conformational transitions, the distribution of conformational changes in synaptic fields of the neuronal population, and the memory loading factor. The latter is represented in the model by a slow potential. It reflects total conformational changes and displaces the membrane potential to monostable conformational regimes, by governing the exit from the recording regime, the potentiation of the neurone, and the readiness to reproduction. A relative amplitude of the slow potential and the coefficient of postconformational modification of ionic conductivity, which provides maximum reliability, accuracy, and capacity of memory, are calculated.

  4. Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility.

    Science.gov (United States)

    Fostad, Ida G; Eidet, Jon R; Utheim, Tor P; Ræder, Sten; Lagali, Neil S; Messelt, Edvard B; Dartt, Darlene A

    2016-01-01

    The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies were consecutively included in the study. The patients underwent a comprehensive ophthalmological work-up and completed self-questionnaires on symptoms of ocular dryness (Ocular Surface Disease Index [OSDI] and McMonnies Dry Eye Questionnaire) and the Sjögren's syndrome (SS) questionnaire (SSQ). Three hundred and eighteen patients (52% women and 48% men) with DED were included. Patient demographics were: 0 to 19 years (1%), 20 to 39 (25%), 40 to 59 (34%), 60 to 79 (35%) and 80 to 99 (5%). Xerostomia, defined as "daily symptoms of dry mouth the last three months" (as presented in SSQ) was reported by 23% of the patients. Female sex was more common among patients with xerostomia (81%) than among non-xerostomia patients (44%; Pxerostomia (60 ± 15 years) were older than those without xerostomia (51 ± 17; Pxerostomia patients (65%) than among non-xerostomia patients (35%; Pxerostomia had a higher OSDI score (19.0 ± 10.0) than those without xerostomia (12.9 ± 8.0; Pxerostomia patients had more pathological meibum expressibility (0.9 ± 0.7) than those without xerostomia (0.7 ± 0.8; P = 0.046). Comparisons of OSDI and ocular signs were performed after controlling for the effects of sex, age and the number of systemic prescription drugs used. In conclusion, xerostomia patients demonstrated a higher DED symptom load and had poorer meibum expressibility than non-xerostomia patients.

  5. Household crowding is associated with higher allostatic load among the Inuit.

    Science.gov (United States)

    Riva, Mylene; Plusquellec, Pierrich; Juster, Robert-Paul; Laouan-Sidi, Elhadji A; Abdous, Belkacem; Lucas, Michel; Dery, Serge; Dewailly, Eric

    2014-04-01

    Household crowding is an important problem in some aboriginal communities that is reaching particularly high levels among the circumpolar Inuit. Living in overcrowded conditions may endanger health via stress pathophysiology. This study examines whether higher household crowding is associated with stress-related physiological dysregulations among the Inuit. Cross-sectional data on 822 Inuit adults were taken from the 2004 Qanuippitaa? How are we? Nunavik Inuit Health Survey. Chronic stress was measured using the concept of allostatic load (AL) representing the multisystemic biological 'wear and tear' of chronic stress. A summary index of AL was constructed using 14 physiological indicators compiled into a traditional count-based index and a binary variable that contrasted people at risk on at least seven physiological indicators. Household crowding was measured using indicators of household size (total number of people and number of children per house) and overcrowding defined as more than one person per room. Data were analysed using weighted Generalised Estimating Equations controlling for participants' age, sex, income, diet and involvement in traditional activities. Higher household crowding was significantly associated with elevated AL levels and with greater odds of being at risk on at least seven physiological indicators, especially among women and independently of individuals' characteristics. This study demonstrates that household crowding is a source of chronic stress among the Inuit of Nunavik. Differential housing conditions are shown to be a marker of health inequalities among this population. Housing conditions are a critical public health issue in many aboriginal communities that must be investigated further to inform healthy and sustainable housing strategies.

  6. Moving Aerospace Structural Design Practice to a Load and Resistance Factor Approach

    Science.gov (United States)

    Larsen, Curtis E.; Raju, Ivatury S.

    2016-01-01

    Aerospace structures are traditionally designed using the factor of safety (FOS) approach. The limit load on the structure is determined and the structure is then designed for FOS times the limit load - the ultimate load. Probabilistic approaches utilize distributions for loads and strengths. Failures are predicted to occur in the region of intersection of the two distributions. The load and resistance factor design (LRFD) approach judiciously combines these two approaches by intensive calibration studies on loads and strength to result in structures that are efficient and reliable. This paper discusses these three approaches.

  7. Higher prevalence of risk factors for type 2 diabetes mellitus and subsequent higher incidence in men

    DEFF Research Database (Denmark)

    Almdal, Thomas; Scharling, Henrik; Jensen, Jan Skov

    2008-01-01

    , non-fasting blood glucose and triglycerides. Significantly more men (242, 5.4%) than women (152, 2.5%) developed type 2 DM. The odds ratio (OR) for developing diabetes with a BMI above 30 kg/m(2) compared to a BMI of 20-25 kg/m(2) was 8.1 in women and 6.3 in men; for a non-fasting plasma glucose of 8.......4-11.0 mmol/l compared to a plasma glucose of 5.5-6.4, the ORs were 7.8 in women and 4.7 in men. The OR for developing diabetes in persons with a non-fasting triglyceride level above 2.0 mmol/l compared to 1.0-2.0 mmol/l was 1.8 in both sexes; women with non -fasting triglycerides below 1.0 mmol/l had...... or non-fasting plasma glucose >11.1 mmol/l) were excluded. Some 6154 women and 4733 men were studied and followed up in 1981-1983 or in 1991-1994. The significance of risk factors was examined by multiple logistic regression analysis. RESULTS: Initially, a higher proportion of men than women had high...

  8. Sustainable railway bridges with higher axle loads:monitoring examples from northern Sweden

    OpenAIRE

    Elfgren, Lennart; Enochsson, Ola; Täljsten, Björn; Paulsson, Björn

    2007-01-01

    Monitoring of several railway bridges has been carried out in northern Sweden in order to increase the allowable axle load. The work is part of a European Integrated Project "Sustainable Bridges - Assessment for Future Traffic Demands and Longer Lives". The paper describes the project and gives some examples of applications. Monitoring of several railway bridges has been carried out in northern Sweden in order to increase the allowable axle load. The work is part of a European Integrated P...

  9. Applying to Higher Education: Information Sources and Choice Factors

    Science.gov (United States)

    Simoes, Claudia; Soares, Ana Maria

    2010-01-01

    Higher education institutions are facing increasingly complex challenges, which demand a deeper understanding of the sources prospective students use when applying to a higher education institution. This research centres on students' decision-making process for higher education institutions, focusing on the pre-purchase period, and, in particular,…

  10. Is Higher Education Economically Unsustainable? An Exploration of Factors That Undermine Sustainability Assessments of Higher Education

    Science.gov (United States)

    Maragakis, Antonios; van den Dobbelsteen, Andy; Maragakis, Alexandros

    2016-01-01

    As students continue to review the sustainability of higher education institutions, there is a growing need to understand the economic returns of degrees as a function of a sustainable institution. This paper reviews a range of international research to summarize the economic drivers of higher education attainment. Although the cost inputs to…

  11. Impact of Higher Fidelity Models on Simulation of Active Aerodynamic Load Control For Fatigue Damage Reduction

    NARCIS (Netherlands)

    Resor, B.; Wilson, D.; Berg, D.; Berg, J.; Barlas, T.; Van Wingerden, J.W.; Van Kuik, G.A.M.

    2010-01-01

    Active aerodynamic load control of wind turbine blades is being investigated by the wind energy research community and shows great promise, especially for reduction of turbine fatigue damage in blades and nearby components. For much of this work, full system aeroelastic codes have been used to

  12. Factors Influencing Assessment Quality in Higher Vocational Education

    Science.gov (United States)

    Baartman, Liesbeth; Gulikers, Judith; Dijkstra, Asha

    2013-01-01

    The development of assessments that are fit to assess professional competence in higher vocational education requires a reconsideration of assessment methods, quality criteria and (self)evaluation. This article examines the self-evaluations of nine courses of a large higher vocational education institute. Per course, 4-11 teachers and 3-10…

  13. Assessment of Various Risk Factors for Success of Delayed and Immediate Loaded Dental Implants: A Retrospective Analysis.

    Science.gov (United States)

    Prasant, M C; Thukral, Rishi; Kumar, Sachin; Sadrani, Sannishth M; Baxi, Harsh; Shah, Aditi

    2016-10-01

    Ever since its introduction in 1977, a minimum of few months of period is required for osseointegration to take place after dental implant surgery. With the passage of time and advancements in the fields of dental implant, this healing period is getting smaller and smaller. Immediate loading of dental implants is becoming a very popular procedure in the recent time. Hence, we retrospectively analyzed the various risk factors for the failure of delayed and immediate loaded dental implants. In the present study, retrospective analysis of all the patients was done who underwent dental implant surgeries either by immediate loading procedure or by delayed loading procedures. All the patients were divided broadly into two groups with one group containing patients in which delayed loaded dental implants were placed while other consisted of patients in whom immediate loaded dental implants were placed. All the patients in whom follow-up records were missing and who had past medical history of any systemic diseases were excluded from the present study. Evaluation of associated possible risk factors was done by classifying the predictable factors as primary and secondary factors. All the results were analyzed by Statistical Package for the Social Sciences (SPSS) software. Kaplan-Meier survival analyses and chi-square test were used for assessment of level of significance. In delayed and immediate group of dental implants, mean age of the patients was 54.2 and 54.8 years respectively. Statistically significant results were obtained while comparing the clinical parameters of the dental implants in both the groups while demographic parameters showed nonsignificant correlation. Significant higher risk of dental implant failure is associated with immediate loaded dental implants. Tobacco smoking, shorter implant size, and other risk factors play a significant role in predicting the success and failure of dental implants. Delayed loaded dental implant placement should be preferred

  14. The use of simulated rainfall to study the discharge process and the influence factors of urban surface runoff pollution loads.

    Science.gov (United States)

    Qinqin, Li; Qiao, Chen; Jiancai, Deng; Weiping, Hu

    2015-01-01

    An understanding of the characteristics of pollutants on impervious surfaces is essential to estimate pollution loads and to design methods to minimize the impacts of pollutants on the environment. In this study, simulated rainfall equipment was constructed to investigate the pollutant discharge process and the influence factors of urban surface runoff (USR). The results indicated that concentrations of total suspended solids (TSS), total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (COD) appeared to be higher in the early period and then decreased gradually with rainfall duration until finally stabilized. The capacity and particle size of surface dust, rainfall intensity and urban surface slopes affected runoff pollution loads to a variable extent. The loads of TP, TN and COD showed a positive relationship with the surface dust capacity, whereas the maximum TSS load appeared when the surface dust was 0.0317 g·cm⁻². Smaller particle sizes (pollution carrying capacity of runoff, leading to higher pollution loads. Knowledge of the influence factors could assist in the management of USR pollution loads.

  15. 14 CFR 25.527 - Hull and main float load factors.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull and main float load factors. 25.527... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Water Loads § 25.527 Hull and main... 1=empirical hull station weighing factor, in accordance with figure 2 of appendix B. (7) r x=ratio...

  16. Partial safety factors for berthing velocity and loads on marine structures

    NARCIS (Netherlands)

    Roubos, A.A.; Peters, D.J.; Groenewegen, Leon; Steenbergen, R.

    2018-01-01

    Design methods for marine structures have evolved into load and resistance factor design, however existing partial safety factors related to berthing velocity and loads have not been verified and validated by measurement campaigns. In this study, field observations of modern seagoing vessels

  17. Reliability-Based Calibration of Load Duration Factors for Timber Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Svensson, Staffan; Stang, Birgitte Friis Dela

    2005-01-01

    John Dalsgaard Sørensen, Staffan Svensson, Birgitte Dela Stang : Reliability-Based Calibration of Load Duration Factors for Timber Structures     Abstract :   The load bearing capacity of timber structures decrease with time depending on the type of load and timber. Based on representative limit...... states and stochastic models for timber structures, load duration factors are calibrated using probabilistic methods. Load duration e.ects are estimated on basis of simulation of realizations of wind, snow and imposed loads in accordance with the load models in the Danish structural codes. Three damage...... accumulation models are considered, namely Gerhards model, Barrett and Foschi _ s model and Foschi and Yao _ s model. The parameters in these models are .tted by the Maximum Likelihood Method using data relevant for Danish structural timber and the statistical uncertainty is quanti .ed. The reliability...

  18. Calibration of Load Duration Factor kmod

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Stang, Birgitte Friis Dela; Svensson, Staffan

    and the stochastic models are formulated in accordance with the load models in the Danish structural codes, DS 409, and DS 410. three damage accumulation models are considered, namely Gerhards model, Barret & Foschi's model, and Foschi & Yao's model. The parameters in these moels are fitted using data relevant...

  19. Quality Instruction as a Motivating Factor in Higher Education

    Science.gov (United States)

    Sogunro, Olusegun A.

    2017-01-01

    The importance of quality instruction in motivating students in higher education cannot be overemphasized. Without quality instruction, students' motivation to learn recedes. Five focus groups of graduate students aided the data collection for this study. More than one-third of the 119 participating graduate students involved in this study claimed…

  20. Factors Influencing the Job Satisfaction of Academics in Higher Education

    Science.gov (United States)

    Schulze, S.

    2006-01-01

    Since there has not been much research focus on job satisfaction in Higher Education in South Africa, this article describes the job satisfaction of these academics in times of transformation. A survey design involved 94 respondents from similar departments at a residential and a distance education institution. A questionnaire focused on teaching,…

  1. Factor Analysis of the Aggregated Electric Vehicle Load Based on Data Mining

    Directory of Open Access Journals (Sweden)

    Yao Wang

    2012-06-01

    Full Text Available Electric vehicles (EVs and the related infrastructure are being developed rapidly. In order to evaluate the impact of factors on the aggregated EV load and to coordinate charging, a model is established to capture the relationship between the charging load and important factors based on data mining. The factors can be categorized as internal and external. The internal factors include the EV battery size, charging rate at different places, penetration of the charging infrastructure, and charging habits. The external factor is the time-of-use pricing (TOU policy. As a massive input data is necessary for data mining, an algorithm is implemented to generate a massive sample as input data which considers real-world travel patterns based on a historical travel dataset. With the input data, linear regression was used to build a linear model whose inputs were the internal factors. The impact of the internal factors on the EV load can be quantified by analyzing the sign, value, and temporal distribution of the model coefficients. The results showed that when no TOU policy is implemented, the rate of charging at home and range anxiety exerts the greatest influence on EV load. For the external factor, a support vector regression technique was used to build a relationship between the TOU policy and EV load. Then, an optimization model based on the relationship was proposed to devise a TOU policy that levels the load. The results suggest that implementing a TOU policy reduces the difference between the peak and valley loads remarkably.

  2. Measurement of the pion form factor at higher energies

    Energy Technology Data Exchange (ETDEWEB)

    Mack, D.J. [CEBAF, Newport News, VA (United States)

    1994-04-01

    One of the strongest arguments for increasing the nominal CEBAF beam energy to equal or exceed 6 GeV is that one would be able to make quality high Q{sup 2} measurements of the charged pion form factor.

  3. Factors influencing the job satisfaction of academics in higher ...

    African Journals Online (AJOL)

    These included university context, being employed on a full-time or part-time basis, rank, ethnic group, union membership and gender. Factors causing satisfaction and dissatisfaction were identified. These were sometimes influenced by the above-mentioned demographics. Three-quarters of the sample indicated that, ...

  4. The Meaning of Higher-Order Factors in Reflective-Measurement Models

    Science.gov (United States)

    Eid, Michael; Koch, Tobias

    2014-01-01

    Higher-order factor analysis is a widely used approach for analyzing the structure of a multidimensional test. Whenever first-order factors are correlated researchers are tempted to apply a higher-order factor model. But is this reasonable? What do the higher-order factors measure? What is their meaning? Willoughby, Holochwost, Blanton, and Blair…

  5. Factor Analysis on Criteria Affecting Lean Retrofit for Energy Efficient Initiatives in Higher Learning Institution Buildings

    Directory of Open Access Journals (Sweden)

    Abidin Nur IzieAdiana

    2017-01-01

    Full Text Available The expansion of Higher Learning Institution (HLI is a global concerns on energy demand due to campus act like a small city. Intensive mode of operation of a building is correlated to the energy utilization. Improvement in the current energy efficiency is crucial effort to minimize the environmental effect through minimisation of energy in operation by retrofitting and upgrade the existing building system or components to be more efficient. Basically, there are three recommended steps for the improvement known as lean initiatives, green technology and clean energy in response to becoming zero energy solutions for building. The deliberation of this paper is aimed to highlight the criteria affecting in retrofitting of existing building in HLI with lean initiatives in order to achieve energy efficiency and reduction of energy comsumption. Attention is devoted to reviewing the lean energy retrofitting initiatives criteria for daylighting (side lighting, daylighting (skylight and glazing. The questionnaire survey was employed and distributed to the architects who has an expertise in green building design. Factor analysis was adopted as a method of analysis by using Principal Component with Varimax Rotation. The result is presented through summarizing the sub-criteria according to its importance with a factor loading 0.50 and above. The result found that majority of the criteria developed achieved the significant factor loading value and in accordance with the protocal of analysis. In conclusion the results from analysis of this paper assists the stakeholders in assessing the significant criteria based on the desired lean energy retrofitting initiatives and also provides a huge contribution for future planning improvement in existing buildings to become an energy efficient building.

  6. Higher prevalence of risk factors for type 2 diabetes mellitus and subsequent higher incidence in men

    DEFF Research Database (Denmark)

    Almdal, T.; Scharling, H.; Jensen, J.S.

    2008-01-01

    Background: This study investigates risk factors and the incidence of type 2 diabetes mellitus (type 2 DM) in both sexes of a northern European population. Methods: A total of 14,223 randomly selected men and women were studied from 1976 to 1978. Patients with diabetes (self-reported type 2 DM......, non-fasting blood glucose and triglycerides. Significantly more men (242, 5.4%) than women (152, 2.5%) developed type 2 DM. The odds ratio (OR) for developing diabetes with a BMI above 30 kg/m(2) compared to a BMI of 20-25 kg/m(2) was 8.1 in women and 6.3 in men; for a non-fasting plasma glucose of 8.......4-11.0 mmol/l compared to a plasma glucose of 5.5-6.4, the ORs were 7.8 in women and 4.7 in men. The OR for developing diabetes in persons with a non-fasting triglyceride level above 2.0 mmol/l compared to 1.0-2.0 mmol/l was 1.8 in both sexes; women with non -fasting triglycerides below 1.0 mmol/l had...

  7. CEBAF at higher energies and the kaon electromagnetic form factor

    Energy Technology Data Exchange (ETDEWEB)

    Baker, O.K.

    1994-04-01

    The electromagnetic production of strangeness, the physics of exciting systems having strangeness degrees of freedom (production of hadrons with one or more strange constituent quarks) using electromagnetic probes (real or virtual photons), is one of the frontier areas of research which will be investigated at the Continuous Electron Beam Accelerator Facility (CEBAF) when it becomes operational. CEBAF is expected to have an important impact upon this field of research using its specialized set of detection instruments and high quality electron beam. This paper focusses upon one aspect of the associated production of strangeness - the determination of the kaon electromagnetic form factor at high squared momentum transfers.

  8. Mean Velocity vs. Mean Propulsive Velocity vs. Peak Velocity: Which Variable Determines Bench Press Relative Load With Higher Reliability?

    Science.gov (United States)

    García-Ramos, Amador; Pestaña-Melero, Francisco L; Pérez-Castilla, Alejandro; Rojas, Francisco J; Gregory Haff, G

    2018-05-01

    García-Ramos, A, Pestaña-Melero, FL, Pérez-Castilla, A, Rojas, FJ, and Haff, GG. Mean velocity vs. mean propulsive velocity vs. peak velocity: which variable determines bench press relative load with higher reliability? J Strength Cond Res 32(5): 1273-1279, 2018-This study aimed to compare between 3 velocity variables (mean velocity [MV], mean propulsive velocity [MPV], and peak velocity [PV]): (a) the linearity of the load-velocity relationship, (b) the accuracy of general regression equations to predict relative load (%1RM), and (c) the between-session reliability of the velocity attained at each percentage of the 1-repetition maximum (%1RM). The full load-velocity relationship of 30 men was evaluated by means of linear regression models in the concentric-only and eccentric-concentric bench press throw (BPT) variants performed with a Smith machine. The 2 sessions of each BPT variant were performed within the same week separated by 48-72 hours. The main findings were as follows: (a) the MV showed the strongest linearity of the load-velocity relationship (median r = 0.989 for concentric-only BPT and 0.993 for eccentric-concentric BPT), followed by MPV (median r = 0.983 for concentric-only BPT and 0.980 for eccentric-concentric BPT), and finally PV (median r = 0.974 for concentric-only BPT and 0.969 for eccentric-concentric BPT); (b) the accuracy of the general regression equations to predict relative load (%1RM) from movement velocity was higher for MV (SEE = 3.80-4.76%1RM) than for MPV (SEE = 4.91-5.56%1RM) and PV (SEE = 5.36-5.77%1RM); and (c) the PV showed the lowest within-subjects coefficient of variation (3.50%-3.87%), followed by MV (4.05%-4.93%), and finally MPV (5.11%-6.03%). Taken together, these results suggest that the MV could be the most appropriate variable for monitoring the relative load (%1RM) in the BPT exercise performed in a Smith machine.

  9. An estimation of finger-tapping rates and load capacities and the effects of various factors.

    Science.gov (United States)

    Ekşioğlu, Mahmut; İşeri, Ali

    2015-06-01

    The aim of this study was to estimate the finger-tapping rates and finger load capacities of eight fingers (excluding thumbs) for a healthy adult population and investigate the effects of various factors on tapping rate. Finger-tapping rate, the total number of finger taps per unit of time, can be used as a design parameter of various products and also as a psychomotor test for evaluating patients with neurologic problems. A 1-min tapping task was performed by 148 participants with maximum volitional tempo for each of eight fingers. For each of the tapping tasks, the participant with the corresponding finger tapped the associated key in the standard position on the home row of a conventional keyboard for touch typing. The index and middle fingers were the fastest fingers for both hands, and little fingers the slowest. All dominant-hand fingers, except little finger, had higher tapping rates than the fastest finger of the nondominant hand. Tapping rate decreased with age and smokers tapped faster than nonsmokers. Tapping duration and exercise had also significant effect on tapping rate. Normative data of tapping rates and load capacities of eight fingers were estimated for the adult population. In designs of psychomotor tests that require the use of tapping rate or finger load capacity data, the effects of finger, age, smoking, and tapping duration need to be taken into account. The findings can be used for ergonomic designs requiring finger-tapping capacity and also as a reference in psychomotor tests. © 2015, Human Factors and Ergonomics Society.

  10. New conceptual copper alloy bearing for diesel engine to achieve longer life under higher load; Diesel engine yo komen`atsu chojumyo jikuuke no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Tomikawa, T; Oshiro, H; Hashizume, K; Kamiya, S [Taiho Kogyo Co. Ltd., Aichi (Japan)

    1997-10-01

    Recently, the requirement like higher output, lower fuel consumption and cleaner exhaust gas for automotive engines has been increased. As a result, especially, higher bearing performance is required for diesel engine under a higher unit load and longer period. For this reason, we have developed the new conceptual copper alloy bearing to achieve higher performance under a higher unit load. This paper describes about the performance of this new bearing material. 3 refs., 12 figs., 5 tabs.

  11. Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes

    NARCIS (Netherlands)

    Juffer, P.; Jaspers, R.T.; Lips, P.; Bakker, A.D.; Klein-Nulend, J.

    2012-01-01

    Lack of physical activity results in muscle atrophy and bone loss, which can be counteracted by mechanical loading. Similar molecular signaling pathways are involved in the adaptation of muscle and bone mass to mechanical loading. Whether anabolic and metabolic factors regulating muscle mass, i.e.,

  12. The effect of some ecological factors on the intestinal parasite loads ...

    Indian Academy of Sciences (India)

    Some ecological factors that might potentially influence intestinal parasite loads in the Asian elephant (Elephas maximus Linn.) were investigated in the Nilgiris, southern India. Fresh dung samples from identified animals were analysed, and the number of eggs/g of dung used as an index of parasite load. Comparisons ...

  13. Anterior cruciate ligament injuries in soccer: Loading mechanisms, risk factors, and prevention programs

    Directory of Open Access Journals (Sweden)

    Boyi Dai

    2014-12-01

    Full Text Available Anterior cruciate ligament (ACL injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.

  14. Load and resistance factor rating (LRFR) in New York State : volume II.

    Science.gov (United States)

    2011-09-01

    This report develops a Load and Resistance Factor Rating (NYS-LRFR) methodology : for New York bridges. The methodology is applicable for the rating of existing : bridges, the posting of under-strength bridges, and checking Permit trucks. The : propo...

  15. Load and resistance factor rating (LRFR) in New York State : volume I.

    Science.gov (United States)

    2011-09-01

    This report develops a Load and Resistance Factor Rating (NYS-LRFR) methodology : for New York bridges. The methodology is applicable for the rating of existing : bridges, the posting of under-strength bridges, and checking Permit trucks. The : propo...

  16. Safeguarding subcriticality during loading and shuffling operations in the higher density of the RSG-GAS's silicide core

    International Nuclear Information System (INIS)

    Sembiring, T.M.; Kuntoro, I.

    2003-01-01

    The core conversion program of the RSG-GAS reactor is to convert the all-oxide to all-silicide core. The silicide equilibrium core with fuel meat density of 3.55 gU cm -3 is an optimal core for RSG-GAS reactor and it can significantly increase the operation cycle length from 25 to 32 full power days. Nevertheless, the subcriticality of the shutdown core and the shutdown margin are lower than of the oxide core. Therefore, the deviation of subcriticality condition in the higher silicide core caused by the fuel loading and shuffling error should be reanalysed. The objective of this work is to analyse the sufficiency of the subcriticality condition of the shutdown core to face the worst condition caused by an error during loading and shuffling operations. The calculations were carried out using the 2-dimensional multigroup neutron diffusion code of Batan-FUEL. In the fuel handling error, the calculated results showed that the subcriticality condition of the shutdown higher density silicide equilibrium core of RSG-GAS can be maintained. Therefore, all fuel management steps are fixed in the present reactor operation manual can be applied in the higher silicide equilibrium core of RSG-GAS reactor. (author)

  17. Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load

    Directory of Open Access Journals (Sweden)

    N. Wolfson

    2012-01-01

    Full Text Available Objective. Adiponectin has anti-atherogenic and anti-inflammatory properties. We investigated the influence of adiponectin on glucose tolerance status, adiposity and cardiovascular risk factors (CVRFs. Design and Patients. Study consisted of 107 subjects: 55 with normal glucose tolerance (NGT and 52 with impaired glucose regulation (IGR who were divided into two groups: 24 subjects with impaired fasting glucose (IFG Group and 28 patients with type 2 diabetes mellitus (DM Group. In additional analysis, study participants were divided into two groups, according to CVRFs: low and high risk. Measurements: Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin. Measurements. Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin. Results. Adiponectin was significantly higher in NGT group than in IFG (=0.003 and DM (=0.01 groups. Adiponectin was significantly, positively associated with HDL and inversely associated with glucose, HbA1c, ALT, AST, TG, HOMA-IR. Patients with higher CVRFs load have lesser adiponectin compared to patients with low cardiovascular risk <0.0001. Adiponectin was inversely associated with the number of risk factors (=−0.430, =0.0001. Conclusions. Circulating adiponectin was significantly lower in subjects with different degree of IGR compared to subjects with normal glucose homeostasis. Adiponectin was significantly lower in high risk group than low risk group and decreased concurrently with increased number of CVRFs.

  18. Field profile and loading measurements on higher order modes in a two cell 500 MHz superconducting structure

    International Nuclear Information System (INIS)

    Barry, W.; Edighoffer, J.; Chattopadhyay, S.; Fornaco, S.

    1992-01-01

    The Infrared Free Electron Laser, being designed at LBL as part of the Chemical Dynamics Research Laboratory, is based on a 500 MHz superconducting linac driver that consists of five 4-cell structures of the CERN/DESY type. A 500 MHz, 2-cell version of this structure is being used in a joint Stanford/LBL/BNL program to study accelerator issues relevant to the FEL applications. As part of this study, field profile and loading measurements of higher order modes have been made on the prototype structure. (Author) 3 refs., 2 figs., tab

  19. Field profile and loading measurements on higher order modes in a two cell 500 MHz superconducting structure

    International Nuclear Information System (INIS)

    Barry, W.; Edighoffer, J.; Chattopadhyay, S.; Fornaca, S.

    1992-08-01

    The Infrared Free Electron Laser, being designed at LBL as part of the Chemical Dynamics Research Laboratory, is based on a 500 MHz superconducting linac driver that consists of five 4-cell structures of the CERN/DESY type. A 500 MHz, 2-cell version of this structure is being used in a joint Stanford/LBL/BNL program to study accelerator issues relevant to the FEL applications. As part of this study, field profile and loading measurements of higher order modes have been made on the prototype structure

  20. Power factor improvement in three-phase networks with unbalanced inductive loads using the Roederstein ESTAmat RPR power factor controller

    Science.gov (United States)

    Diniş, C. M.; Cunţan, C. D.; Rob, R. O. S.; Popa, G. N.

    2018-01-01

    The paper presents the analysis of a power factor with capacitors banks, without series coils, used for improving power factor for a three-phase and single-phase inductive loads. In the experimental measurements, to improve the power factor, the Roederstein ESTAmat RPR power factor controller can command up to twelve capacitors banks, while experimenting using only six capacitors banks. Six delta capacitors banks with approximately equal reactive powers were used for experimentation. The experimental measurements were carried out with a three-phase power quality analyser which worked in three cases: a case without a controller with all capacitors banks permanently parallel connected with network, and two other cases with power factor controller (one with setting power factor at 0.92 and the other one at 1). When performing experiments with the power factor controller, a current transformer was used to measure the current on one phase (at a more charged or less loaded phase).

  1. Application of Fracture Mechanics to Specify the Proof Load Factor for Clamp Band Systems of Launch Vehicles

    Science.gov (United States)

    Singaravelu, J.; Sundaresan, S.; Nageswara Rao, B.

    2013-04-01

    This article presents a methodology for evaluation of the proof load factor (PLF) for clamp band system (CBS) made of M250 Maraging steel following fracture mechanics principles.CBS is most widely used as a structural element and as a separation system. Using Taguchi's design of experiments and the response surface method (RSM) the compact tension specimens were tested to establish an empirical relation for the failure load ( P max) in terms of the ultimate strength, width, thickness, and initial crack length. The test results of P max closely matched with the developed RSM empirical relation. Crack growth rates of the maraging steel in different environments were examined. Fracture strength (σf) of center surface cracks and through-crack tension specimens are evaluated utilizing the fracture toughness ( K IC). Stress induced in merman band at flight loading conditions is evaluated to estimate the higher load factor and PLF. Statistical safety factor and reliability assessments were made for the specified flaw sizes useful in the development of fracture control plan for CBS of launch vehicles.

  2. Environmental load factors and system strength evaluation of offshore jacket platforms

    CERN Document Server

    Nizamani, Zafarullah

    2015-01-01

    This book presents a study for the determination of environmental load factors for Jacket Platforms in Malaysia and a methodology to determine the life extension of aging platforms. The simplified methods described here could be used for determining not only structural reliability but also safety factors. Its content is particularly interesting to design and maintenance engineers who are working in offshore or onshore industry.

  3. Evaluation of the Effect of Platelet-Released Growth Factor and Immediate Orthodontic Loading on the Removal Torque of Miniscrews.

    Science.gov (United States)

    Bayani, Shahin; Masoomi, Fatemeh; Aghaabbasi, Sharereh; Farsinejad, Alireza

    2016-01-01

    The purpose of this study was to evaluate the effect of platelet-released growth factor (PRGF) and immediate orthodontic forces on the removal torque of miniscrews. This study was conducted on three male dogs aged 6 to 8 months with a body weight of 17.6 to 18.4 kg. Sixty miniscrews were inserted in the posterior aspect of the femur. There were four groups, including loaded miniscrews with application of PRGF, unloaded miniscrews without application of PRGF, unloaded miniscrews with PRGF, and loaded miniscrews without PRGF. Twenty miniscrews were inserted in the femoral bone of one foot of each dog, including all the aforementioned subgroups. After 12 weeks, the miniscrews were removed by a removal torque tester device and measured in newton centimeters. The mean removal torque values in four groups of immediately loaded screws with PRGF, unloaded screws with PRGF, immediately loaded screws without PRGF, and unloaded screws without PRGF were 19.68, 21.74, 13.65, and 15.46 Ncm, respectively. It was shown that the mean removal torque value for the group with PRGF was significantly higher than that in the other groups (P = .0001). Although there was a tendency toward a decrease in removal torque value with immediate loading, it was not statistically significant (P = .21). According to the results of this study, applying PRGF with miniscrews increased their stability, but the delivery of immediate force on miniscrews had no effect on the miniscrews' stability.

  4. Importance of nuclear station load factor in applied ro energy policies

    International Nuclear Information System (INIS)

    Gomes, Daniel de Souza

    2015-01-01

    Load factor is the ration between the energy produced by a station and the energy it would have produced running at maximum power. The factor intends for all types of commercial reactors. Nuclear plants continuously provide over 11% of the world's electricity. The reactors for which data were available generated 618.7 TWh of electricity in 2014. Typical load factor was around 75% in worldwide during the first quarter of 2015. In this manner, it obtained from an average, three-monthly or yearly. The regular load factor of the reactors in operation was around 56% in 1970. While, in 1980's decade, we have an increase to 63%, the same situation occurred in next the decade and suffering increasing to 73%. Currently, the load factor reaches 78%. Accidents are seasonal factors, with the occurrence of reduction of power generation plants. In 2015 in January, there are over 437 operable commercial reactors in 31 countries, with over 377,728 MWe of full capacity. In Brazil, total capacity is 1901 MWe, with around 2.8% of electricity energy consumed. The primary objective of this study was to find a forecast model that express the evolution of the load factor in the next years. In recent years occur an extensive development of pressurized water reactors in Asia. The periodicity of seasonal effects on the performance of nuclear power plants due to aging. However, the impact of plant age depended on new technologies that allow the growth of the performance. The accident of Fukushima was an inflection point for energy policies. The event produced a trend that reduced the load in the world. (author)

  5. Optimization of economic load dispatch of higher order general cost polynomials and its sensitivity using modified particle swarm optimization

    International Nuclear Information System (INIS)

    Saber, Ahmed Yousuf; Chakraborty, Shantanu; Abdur Razzak, S.M.; Senjyu, Tomonobu

    2009-01-01

    This paper presents a modified particle swarm optimization (MPSO) for constrained economic load dispatch (ELD) problem. Real cost functions are more complex than conventional second order cost functions when multi-fuel operations, valve-point effects, accurate curve fitting, etc., are considering in deregulated changing market. The proposed modified particle swarm optimization (PSO) consists of problem dependent variable number of promising values (in velocity vector), unit vector and error-iteration dependent step length. It reliably and accurately tracks a continuously changing solution of the complex cost function and no extra concentration/effort is needed for the complex higher order cost polynomials in ELD. Constraint management is incorporated in the modified PSO. The modified PSO has balance between local and global searching abilities, and an appropriate fitness function helps to converge it quickly. To avoid the method to be frozen, stagnated/idle particles are reset. Sensitivity of the higher order cost polynomials is also analyzed visually to realize the importance of the higher order cost polynomials for the optimization of ELD. Finally, benchmark data sets and methods are used to show the effectiveness of the proposed method. (author)

  6. What is the relationship between mental workload factors and cognitive load types?

    Science.gov (United States)

    Galy, Edith; Cariou, Magali; Mélan, Claudine

    2012-03-01

    The present study tested the hypothesis of an additive interaction between intrinsic, extraneous and germane cognitive load, by manipulating factors of mental workload assumed to have a specific effect on either type of cognitive load. The study of cognitive load factors and their interaction is essential if we are to improve workers' wellbeing and safety at work. High cognitive load requires the individual to allocate extra resources to entering information. It is thought that this demand for extra resources may reduce processing efficiency and performance. The present study tested the effects of three factors thought to act on either cognitive load type, i.e. task difficulty, time pressure and alertness in a working memory task. Results revealed additive effects of task difficulty and time pressure, and a modulation by alertness on behavioral, subjective and psychophysiological workload measures. Mental overload can be the result of a combination of task-related components, but its occurrence may also depend on subject-related characteristics, including alertness. Solutions designed to reduce incidents and accidents at work should consider work organization in addition to task constraints in so far that both these factors may interfere with mental workload. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. The effect of load factor on fission product decay heat from discharged reactor fuel

    International Nuclear Information System (INIS)

    Davies, B.S.J.

    1978-07-01

    A sum-of-exponentials expression representing the decay heat power following a burst thermal irradiation of 235 U has been used to investigate the effect of load factor during irradiation on subsequent decay heat production. A sequence of random numbers was used to indicate reactor 'on' and 'off' periods for irradiations which continued for a total of 1500 days at power and were followed by 100 days cooling. It was found that for these conditions decay heat is almost proportional to load factor. Estimates of decay heat uncertainty arising from the random irradiation pattern are also given. (author)

  8. Nerve growth factor loaded heparin/chitosan scaffolds for accelerating peripheral nerve regeneration.

    Science.gov (United States)

    Li, Guicai; Xiao, Qinzhi; Zhang, Luzhong; Zhao, Yahong; Yang, Yumin

    2017-09-01

    Artificial chitosan scaffolds have been widely investigated for peripheral nerve regeneration. However, the effect was not as good as that of autologous grafts and therefore could not meet the clinical requirement. In the present study, the nerve growth factor (NGF) loaded heparin/chitosan scaffolds were fabricated via electrostatic interaction for further improving nerve regeneration. The physicochemical properties including morphology, wettability and composition were measured. The heparin immobilization, NGF loading and release were quantitatively and qualitatively characterized, respectively. The effect of NGF loaded heparin/chitosan scaffolds on nerve regeneration was evaluated by Schwann cells culture for different periods. The results showed that the heparin immobilization and NGF loading did not cause the change of bulk properties of chitosan scaffolds except for morphology and wettability. The pre-immobilization of heparin in chitosan scaffolds could enhance the stability of subsequently loaded NGF. The NGF loaded heparin/chitosan scaffolds could obviously improve the attachment and proliferation of Schwann cells in vitro. More importantly, the NGF loaded heparin/chitosan scaffolds could effectively promote the morphology development of Schwann cells. The study may provide a useful experimental basis to design and develop artificial implants for peripheral nerve regeneration and other tissue regeneration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Serviceability design load factors and reliability assessments for reinforced concrete containment structures

    International Nuclear Information System (INIS)

    Han Bong Koo

    1998-01-01

    A reinforced concrete nuclear power plant containment structure is subjected to various random static and stochastic loads during its lifetime. Since these loads involve inherent randomness and other uncertainties, an appropriate probabilistic model for each load must be established in order to perform reliability analysis. The current ASME code for reinforced concrete containment structures are not based on probability concepts. The stochastic nature of natural hazard or accidental loads and the variations of material properties require a probabilistic approach for a rational assessment of structural safety and performance. The paper develops probability-based load factors for the limit state design of reinforced concrete containment structures. The purpose of constructing reinforced concrete containment structure is to protect against radioactive release, and so the use of a serviceability limit state against crack failure that can cause the emission of radioactive materials is suggested as a critical limit state for reinforced concrete containment structures. Load factors for the design of reinforced concrete containment structures are proposed and carried out the reliability assessments. (orig.)

  10. A Market Segmentation Approach for Higher Education Based on Rational and Emotional Factors

    Science.gov (United States)

    Angulo, Fernando; Pergelova, Albena; Rialp, Josep

    2010-01-01

    Market segmentation is an important topic for higher education administrators and researchers. For segmenting the higher education market, we have to understand what factors are important for high school students in selecting a university. Extant literature has probed the importance of rational factors such as teaching staff, campus facilities,…

  11. The second higher education and additional education as factors of development of commercialization in Ukrainian higher education

    Directory of Open Access Journals (Sweden)

    M. V. Strigul

    2017-07-01

    Full Text Available The attention in the article has been drawn to the nature and characteristics of commercialization in the higher education system of Ukraine. It has been noted that commercialization in the consumer society is a social process of transformation of knowledge into a product or service. It provides the growing influence of market relations on the goals and objectives of higher education, promotes the growing importance of knowledge as a source for economic development and focuses on the concept of rooting and academic capitalism and the creation of market-oriented and entrepreneurial universities, which provide dynamic development of economy based on knowledge. Defining the essence of the Ukrainian forms of commercialization, there is a significant role of further and second higher education (that is, the presence of a variety of educational forms, which allows the University receiving the profit in the monetary form. The model of commercialization, which is implemented in Ukrainian higher education, differs from the American and Western European ones, as it is focused on financial returns, not on the economization of intellectual profit. Secondly, a peculiar type of consumer behavior, consumerism, which provides growth of profitability of higher education institutions by a variety of additional services (training, additional courses, further education, developing classes, retaking tests, etc.. The factors of development and dynamics of the Ukrainian forms of commercialization, as well as recommendations for avoiding the negative consequences of the economization and commercialization in higher education structure of modern Ukraine have been considered in the article. It has been noted that the University lost its original purpose and became a huge supermarket, which offers various kinds of knowledge. Rational action considers in the desire to buy the most qualitative product – a diploma from a prestigious University. Nowadays, the higher

  12. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  13. technical note: technical note: on the correctness of load loss factor ...

    African Journals Online (AJOL)

    eobe

    Load Loss Factor (LLF) is a function of the estimate of the losses between the grid supply point and the consumers. estimate ... i.e. the ratio of average demand to peak demand, and using this ratio to determine an approximation to the. LLF via ...

  14. Psychosocial factors and mental work load: a reality perceived by nurses in intensive care units

    Directory of Open Access Journals (Sweden)

    Paula Ceballos-Vásquez

    2015-04-01

    Full Text Available OBJECTIVE: To analyse the perception of psychosocial factors and mental workload of nurses who work in intensive care units. It is hypothesised that nurses in these units could perceive psychosocial risks, manifesting in a high mental work load. The psychosocial dimension related to the position's cognitive demands is hypothesised to mostly explain mental work load. METHOD: Quantitative study, with a descriptive, cross-sectional, and comparative design. A total of 91% of the intensive care unit populations of three Chilean hospitals was surveyed, corresponding to 111 nurses. The instruments utilised included (A a biosociodemographic history questionnaire; (b the SUSESO-ISTAS 21 questionnaire; and (c the Mental Work Load Subjective Scale (ESCAM, in Spanish. RESULTS: In total, 64% and 57% of participants perceived high levels of exposure to the psychosocial risks Psychosocial demands and Double shift, respectively. In addition, a medium-high level of overall mental load was observed. Positive and significant correlations between some of the SUSESO-ISTAS 21 and ESCAM dimensions were obtained. Using a regression analysis, it was determined that three dimensions of the psychosocial risk questionnaire helped to explain 38% of the overall mental load. CONCLUSION: Intensive care unit nurses felt that inadequate psychosocial factors and mental work overload existed in several of the tested dimensions.

  15. System incremental cost calculations using the participation factor load-flow formulation

    International Nuclear Information System (INIS)

    Meisel, J.

    1993-01-01

    The load-flow problem is reformulated such that the use of a slack-bus generator is included only as a special case. This reformulation, known as the participation factor load-flow, includes a total mismatch variable and a defined participation vector, which, in general, distributes this mismatch to all system buses. The slack-bus constraint can still be obtained by defining a particular participation vector. In using the participation factor load-flow in the transpose Jacobian approach to the economic optimal dispatch problem, the paper shows that the value of the system-λ can be controlled such that this value represents the minimal incremental change in generation costs per unit change in system total demand with this demand distributed according to the specified participation vector. Methods using the conventional B-coefficient loss formulas or slack-bus load-flows give system-λ values whereby the unit change in demand must be placed on a fictitious single load-bus or on the slack-bus, respectively. Having a system-λ value which more accurately represents a proposed energy interchange between interconnected systems is very important in developing valid costs for each system. An extensive 28-bus, 8-generator system is included to illustrate these results

  16. Analysis of bus passenger comfort perception based on passenger load factor and in-vehicle time.

    Science.gov (United States)

    Shen, Xianghao; Feng, Shumin; Li, Zhenning; Hu, Baoyu

    2016-01-01

    Although bus comfort is a crucial indicator of service quality, existing studies tend to focus on passenger load and ignore in-vehicle time, which can also affect passengers' comfort perception. Therefore, by conducting surveys, this study examines passengers' comfort perception while accounting for both factors. Then, using the survey data, it performs a two-way analysis of variance and shows that both in-vehicle time and passenger load significantly affect passenger comfort. Then, a bus comfort model is proposed to evaluate comfort level, followed by a sensitivity analysis. The method introduced in this study has theoretical implications for bus operators attempting to improve bus service quality.

  17. Influence of overelastic loading on the stress intensity factor under thermal fatigue conditions

    International Nuclear Information System (INIS)

    Stamm, H.; Munz, D.

    1983-10-01

    Thermal shock loading often creates high thermal stresses which may exceed yield strength of the material in a surface layer. In this report the application of the linear elastic ΔK-concept in the case of cyclic thermal loading within the shakedown region is discussed. To this K-factors for an edge crack in a linear elastic - perfectly plastic plate are calculated using the weight function method and are compared with results obtained with the Finite Element Method. It is shown, that rearrangement stresses during plastic flow in the first cycle must be taken into account developing conservative approximation procedures. (orig.) [de

  18. A New V2G Control Strategy for Load Factor Improvement Using Smoothing Technique

    Directory of Open Access Journals (Sweden)

    CHANHOM, P.

    2017-08-01

    Full Text Available This paper proposes a new vehicle-to-grid (V2G control strategy for improving the load factor in the power network. To operate the proposed strategy, the available storage capacity of the PEVs’ batteries is considered as a battery energy storage system (BESS for charging and discharging an amount of power corresponding to the V2G power command. Due to the remarkable advantages of the technique so-called simple moving average, it is selected for applying in the proposed V2G control strategy. In this research, for investigating the load factor improvement, the essential data including the daily-load profiles with 7-day and 14-day periods are used for the 3 studied cases. These 3 studied cases present the power network with variation of the PEVs locations for describing the PEVs usage and charging or discharging behavior. The performance of the proposed strategy is simulated and verified by the MATPOWER software. The simulation results show that the load factors of the 3 studied cases are improved. Moreover, the encouragement of energy arbitrage for the PEVs owners is also discussed in this paper.

  19. Development of reliability-based load and resistance factor design methods for piping

    International Nuclear Information System (INIS)

    Ayyub, Bilal M.; Hill, Ralph S. III; Balkey, Kenneth R.

    2003-01-01

    Current American Society of Mechanical Engineers (ASME) nuclear codes and standards rely primarily on deterministic and mechanistic approaches to design. The American Institute of Steel Construction and the American Concrete Institute, among other organizations, have incorporated probabilistic methodologies into their design codes. ASME nuclear codes and standards could benefit from developing a probabilistic, reliability-based, design methodology. This paper provides a plan to develop the technical basis for reliability-based, load and resistance factor design of ASME Section III, Class 2/3 piping for primary loading, i.e., pressure, deadweight and seismic. The plan provides a proof of concept in that LRFD can be used in the design of piping, and could achieve consistent reliability levels. Also, the results from future projects in this area could form the basis for code cases, and additional research for piping secondary loads. (author)

  20. Factors controlling strength of structures, and anticipated overstrength for seismic load conditions

    International Nuclear Information System (INIS)

    Singh, A.K.

    1985-01-01

    This paper discusses how the safe shutdown earthquake level, the ratio of operating basis earthquake to safe shutdown earthquake level, the shape of the earthquake spectra and the modeling of the structure affect the seismic overstrength of structures. The relationship between actual mean strength and the minimum specified strength of concrete and structural steel is also presented. The paper identifies which concrete and steel structures are generally sized for earthquake loads and which are generally sized for other factors, e.g., tornado missiles, loss of coolant accident pressure loads, equipment laydown loads and radiation shielding. The results of a study evaluating the mean ultimate capacity of a pressurized water reactor containment are presented to show that in terms of a ground motion, the seismic capacity may be four to five times the design safe shutdown earthquake level

  1. Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

    International Nuclear Information System (INIS)

    Talamo, A.; Gohar, Y.; Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C.

    2012-01-01

    The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

  2. Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, A.; Gohar, Y. [Argonne National Laboratory, 9700 S. Cass Ave, Argonne, IL 60439 (United States); Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C. [Joint Inst. for Power and Nuclear Research-Sosny, 99 Academician A.K.Krasin Str, Minsk 220109 (Belarus)

    2012-07-01

    The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

  3. A load factor based mean-variance analysis for fuel diversification

    Energy Technology Data Exchange (ETDEWEB)

    Gotham, Douglas; Preckel, Paul; Ruangpattana, Suriya [State Utility Forecasting Group, Purdue University, West Lafayette, IN (United States); Muthuraman, Kumar [McCombs School of Business, University of Texas, Austin, TX (United States); Rardin, Ronald [Department of Industrial Engineering, University of Arkansas, Fayetteville, AR (United States)

    2009-03-15

    Fuel diversification implies the selection of a mix of generation technologies for long-term electricity generation. The goal is to strike a good balance between reduced costs and reduced risk. The method of analysis that has been advocated and adopted for such studies is the mean-variance portfolio analysis pioneered by Markowitz (Markowitz, H., 1952. Portfolio selection. Journal of Finance 7(1) 77-91). However the standard mean-variance methodology, does not account for the ability of various fuels/technologies to adapt to varying loads. Such analysis often provides results that are easily dismissed by regulators and practitioners as unacceptable, since load cycles play critical roles in fuel selection. To account for such issues and still retain the convenience and elegance of the mean-variance approach, we propose a variant of the mean-variance analysis using the decomposition of the load into various types and utilizing the load factors of each load type. We also illustrate the approach using data for the state of Indiana and demonstrate the ability of the model in providing useful insights. (author)

  4. Exclusion Factors in Latin American Higher Education: A Preliminary Analyze From University Governing Board Perspective

    Science.gov (United States)

    Castro, Diego; Rodríguez-Gómez, David; Gairín, Joaquín

    2017-01-01

    Access to higher education has increased substantially in Latin America, but inequalities in access to and completion of higher education still remain. In this regard, identifying vulnerable groups and exclusion factors is a priority in Latin America's university systems. The aim of this article is to understand in depth governing board…

  5. Historic Factors Influencing Korean Higher Education. Korean Studies Series, No. 17.

    Science.gov (United States)

    Jeong-kyu, Lee

    This book examines the religious and philosophical factors historically affecting Korean higher education, and the characteristics of contemporary Korean higher education in relation to organizational structure, leadership, and organizational culture. The book is organized into 4 parts, with 11 chapters. Part One focuses on identifying the problem…

  6. Factors for Effective E-learning Integration in Higher Education in ...

    African Journals Online (AJOL)

    This article discusses factors that contribute to effective e-learning integration in higher education in the context of Sub-Sahara Africa. It involved retrieving articles using key words such as e-learning, perceptions, knowledge, skills, implementation, facilities, access, support, learning management system and higher ...

  7. In Situ Loading of Basic Fibroblast Growth Factor Within Porous Silica Nanoparticles for a Prolonged Release

    Directory of Open Access Journals (Sweden)

    Postovit Lynne-Marie

    2009-01-01

    Full Text Available Abstract Basic fibroblast growth factor (bFGF, a protein, plays a key role in wound healing and blood vessel regeneration. However, bFGF is easily degraded in biologic systems. Mesoporous silica nanoparticles (MSNs with well-tailored porous structure have been used for hosting guest molecules for drug delivery. Here, we report an in situ route to load bFGF in MSNs for a prolonged release. The average diameter (d of bFGF-loaded MSNs is 57 ± 8 nm produced by a water-in-oil microemulsion method. The in vitro releasing profile of bFGF from MSNs in phosphate buffer saline has been monitored for 20 days through a colorimetric enzyme linked immunosorbent assay. The loading efficiency of bFGF in MSNs is estimated at 72.5 ± 3%. In addition, the cytotoxicity test indicates that the MSNs are not toxic, even at a concentration of 50 μg/mL. It is expected that the in situ loading method makes the MSNs a new delivery system to deliver protein drugs, e.g. growth factors, to help blood vessel regeneration and potentiate greater angiogenesis.

  8. Orthogonal Higher Order Structure of the WISC-IV Spanish Using Hierarchical Exploratory Factor Analytic Procedures

    Science.gov (United States)

    McGill, Ryan J.; Canivez, Gary L.

    2016-01-01

    As recommended by Carroll, the present study examined the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish) normative sample using higher order exploratory factor analytic techniques not included in the WISC-IV Spanish Technical Manual. Results indicated that the WISC-IV Spanish subtests were…

  9. A Study of Factors Influencing International Students' Choice of Higher Education Institutions

    OpenAIRE

    Akadu, Victor Abia

    2013-01-01

    This paper discusses the factors that influence international students’ choice of higher education institutions. The research conducted using the international students in the University of Nottingham (Malaysia Campus) and Monash University (Malaysia Campus) and survey questionnaires were mainly used to gather primary data for the purpose of this study. Findings from this research indicated that product and university based factors, cost factors, promotion, location and social influences all ...

  10. Surface water acidification and critical loads: exploring the F-factor

    Directory of Open Access Journals (Sweden)

    K. Bishop

    2009-11-01

    Full Text Available As acid deposition decreases, uncertainties in methods for calculating critical loads become more important when judgements have to be made about whether or not further emission reductions are needed. An important aspect of one type of model that has been used to calculate surface water critical loads is the empirical F-factor which estimates the degree to which acid deposition is neutralised before it reaches a lake at any particular point in time relative to the pre-industrial, steady-state water chemistry conditions.

    In this paper we will examine how well the empirical F-functions are able to estimate pre-industrial lake chemistry as lake chemistry changes during different phases of acidification and recovery. To accomplish this, we use the dynamic, process-oriented biogeochemical model SAFE to generate a plausible time series of annual runoff chemistry for ca. 140 Swedish catchments between 1800 and 2100. These annual hydrochemistry data are then used to generate empirical F-factors that are compared to the "actual" F-factor seen in the SAFE data for each lake and year in the time series. The dynamics of the F-factor as catchments acidify, and then recover are not widely recognised.

    Our results suggest that the F-factor approach worked best during the acidification phase when soil processes buffer incoming acidity. However, the empirical functions for estimating F from contemporary lake chemistry are not well suited to the recovery phase when the F-factor turns negative due to recovery processes in the soil. This happens when acid deposition has depleted the soil store of BC, and then acid deposition declines, reducing the leaching of base cations to levels below those in the pre-industrial era. An estimate of critical load from water chemistry during recovery and empirical F functions would therefore result in critical loads that are too low. Therefore, the empirical estimates of the F-factor are a significant source of

  11. Effect of Loads and Other Key Factors on Oil-Transformer Ageing: Sustainability Benefits and Challenges

    Directory of Open Access Journals (Sweden)

    Radu Godina

    2015-10-01

    Full Text Available Transformers are one of the more expensive pieces of equipment found in a distribution network. The transformer’s role has not changed over the last decades. With simple construction and at the same time mechanically robust, they offer long term service that on average can reach half a century. Today, with the ongoing trend to supply a growing number of non-linear loads along with the notion of distributed generation (DG, a new challenge has arisen in terms of transformer sustainability, with one of the possible consequences being accelerated ageing. In this paper we carefully review the existing studies in the literature of the effect of loads and other key factors on oil-transformer ageing. The state-of-the-art is reviewed, each factor is analysed in detail, and in the end a smart transformer protection method is sought in order to monitor and protect it from upcoming challenges.

  12. An exact model for airline flight network optimization based on transport momentum and aircraft load factor

    Directory of Open Access Journals (Sweden)

    Daniel Jorge Caetano

    2017-12-01

    Full Text Available The problem of airline flight network optimization can be split into subproblems such as Schedule Generation (SG and Fleet Assignment (FA, solved in consecutive steps or in an integrated way, usually based on monetary costs and revenue forecasts. A linear pro­gramming model to solve SG and FA in an integrated way is presented, but with an al­ternative approach based on transport momentum and aircraft load factor. This alterna­tive approach relies on demand forecast and allows obtaining solutions considering min­imum average load factors. Results of the proposed model applications to instances of a regional Brazilian airline are presented. The comparison of the schedules generated by the proposed approach against those obtained by applying a model based on mone­tary costs and revenue forecasts demonstrates the validity of this alternative approach for airlines network planning.

  13. Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

    Science.gov (United States)

    Goldstein, Ido; Baek, Songjoon; Presman, Diego M.; Paakinaho, Ville; Swinstead, Erin E.; Hager, Gordon L.

    2017-01-01

    Fasting elicits transcriptional programs in hepatocytes leading to glucose and ketone production. This transcriptional program is regulated by many transcription factors (TFs). To understand how this complex network regulates the metabolic response to fasting, we aimed at isolating the enhancers and TFs dictating it. Measuring chromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous fasting-induced enhancers. By utilizing computational methods in combination with dissecting enhancer features and TF cistromes, we implicated four key TFs regulating the fasting response: glucocorticoid receptor (GR), cAMP responsive element binding protein 1 (CREB1), peroxisome proliferator activated receptor alpha (PPARA), and CCAAT/enhancer binding protein beta (CEBPB). These TFs regulate fuel production by two distinctly operating modules, each controlling a separate metabolic pathway. The gluconeogenic module operates through assisted loading, whereby GR doubles the number of sites occupied by CREB1 as well as enhances CREB1 binding intensity and increases accessibility of CREB1 binding sites. Importantly, this GR-assisted CREB1 binding was enhancer-selective and did not affect all CREB1-bound enhancers. Single-molecule tracking revealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 molecules. These events collectively result in rapid synergistic gene expression and higher hepatic glucose production. Conversely, the ketogenic module operates via a GR-induced TF cascade, whereby PPARA levels are increased following GR activation, facilitating gradual enhancer maturation next to PPARA target genes and delayed ketogenic gene expression. Our findings reveal a complex network of enhancers and TFs that dynamically cooperate to restore homeostasis upon fasting. PMID:28031249

  14. Assessment of vehicular live load and load factors for design of short-span bridges according to the new Egyptian Code

    Directory of Open Access Journals (Sweden)

    Hatem M. Seliem

    2015-04-01

    The study shows that concrete box-girders designed according to ECP-201:2012 and ECP-201:2003 using the ultimate limit state method yield almost the same demand. Despite the increase in the VLL of ECP-201:2012, and consequently the live load forces, concrete I-shaped girder bridges will be subjected to less total factored internal forces in comparison to ECP-201:2003 This is attributed to the interaction between the live to dead loads ratio and the load combinations. Design of composite steel plate girder bridges according to ECP-201:2012 using the allowable stress design method yields over designed sections.

  15. Evaluation on the Effect of Load Follow Controller's Weighting Factors

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Keuk Jong; Lee, Jae Gon [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    there are several important physical effects that limit the possibilities of power variations in NPPs. Some major effects are moderator and xenon effect. Moderator effect is relation with moderator density change and xenon effect is relation with the concentration change of Xe-135 which could affect axial power shape. These effects are more significant with large magnitudes of power variations and they are considered as major disturbances at the aspect of control method. Due to the above physical effects, it is necessary to carefully change nuclear power considering power distribution change in the core. So, when nuclear plants are required to operate on load variation mode, we could control not only reactor power but also power distribution. Generally, power distribution is controlled by reactor operators who have enough experience, whereas reactor power is automatically controlled by automatic controllers. So, it is necessary to design an automatic controller that controls both reactor power and power distribution for frequent load following operation. Korea Hydro and Nuclear Power Co., LTD (KHNP) has been developing automatic load follow controller as a part of Advanced Power Reactor Plus (APR+) development. The developing controller is composed of three algorithms which could control reactor power and axial power shape. This paper aimed to evaluate the effect of the controller’s weighting factors. So, in this paper, we identify the meaning of the weighting factors and the controlled output weighting factors are selected among them. In this study, the effect of output weighting factors is analyzed. According to the simulation results, it is recommended that the weighting factor of power be between 200 and 400 and that of ASI be between 200 and 600. In the near future, based on the study, optimization of power and ASI weighting factors will be performed at the same time.

  16. John Carroll’s Views on Intelligence: Bi-Factor vs. Higher-Order Models

    Directory of Open Access Journals (Sweden)

    A. Alexander Beaujean

    2015-10-01

    Full Text Available The development of factor models is inextricably tied to the history of intelligence research. One of the most commonly-cited scholars in the field is John Carroll, whose three-stratum theory of cognitive ability has been one of the most influential models of cognitive ability in the past 20 years. Nonetheless, there is disagreement about how Carroll conceptualized the factors in his model. Some argue that his model is best represented through a higher-order model, while others argue that a bi-factor model is a better representation. Carroll was explicit about what he perceived the best way to represent his model, but his writings are not always easy to understand. In this article, I clarify his position by first describing the details and implications of bi-factor and higher-order models then show that Carroll’s published views are better represented by a bi-factor model.

  17. Edge loading in metal-on-metal hips: low clearance is a new risk factor.

    Science.gov (United States)

    Underwood, Richard J; Zografos, Angelos; Sayles, Ritchie S; Hart, Alister; Cann, Philippa

    2012-03-01

    The revision rate of large head metal-on-metal and resurfacing hips are significantly higher than conventional total hip replacements. The revision of these components has been linked to high wear caused by edge loading; which occurs when the head-cup contact patch extends over the cup rim. There are two current explanations for this; first, there is loss of entrainment of synovial fluid resulting in breakdown of the lubricating film and second, edge loading results in a large local increase in contact pressure and consequent film thickness reduction at the cup rim, which causes an increase in wear. This paper develops a method to calculate the distance between the joint reaction force vector and the cup rim--the contact patch centre to rim (CPCR) distance. However, the critical distance for the risk of edge loading is the distance from the contact patch edge to rim (CPER) distance. An analysis of explanted hip components, divided into edge worn and non-edge-worn components showed that there was no statistical difference in CPCR values, but the CPER value was significantly lower for edge worn hips. Low clearance hips, which have a more conformal contact, have a larger diameter contact patch and thus are more at risk of edge loading for similarly positioned hips.

  18. Determination of the usage factor of components after cyclic loading using high-resolution microstructural investigations

    International Nuclear Information System (INIS)

    Seibold, A.; Scheibe, A.; Assmann, H.D.

    1989-01-01

    The usage factor can be derived from the quantification of the structure changes and the allocation of the microstructural state to the fatigue curves of the component materials. Using the example of the low alloy fine grain structural steel 20 Mn Mo Ni 5 5 (annealed structure), the relationship between micro-structure and the number of load cycles is shown in the form of a calibration curve. By high resolution structural investigation, the usage factor can be determined to n = N/N B ≅ 0.5 under given vibration stress. Only a small volume sample is required for the electron microscope examination. (orig./DG) [de

  19. Field Study of Live Load Distribution Factors and Dynamic Load Allowance on Reinforced Concrete T-Beam Bridges

    National Research Council Canada - National Science Library

    Trimble, Matthew

    2003-01-01

    .... The vehicle under consideration in this study was a U.S. Army Palletized Loading System (PLS) military vehicle. Results from this evaluation were compared to those obtained from a civilian dump truck owned by the Virginia Department of Transportation...

  20. Dutch monitor on stress and physical load: risk factors, consequences, and preventive action.

    Science.gov (United States)

    Houtman, I L; Goudswaard, A; Dhondt, S; van der Grinten, M P; Hildebrandt, V H; van der Poel, E G

    1998-02-01

    Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational and environmental variables that facilitate preventive actions. Information was gathered from employers, employees, and employees' representatives. The monitor was used with a nationally representative sample of companies in industry, wholesale trade, and banking and finance, 782 companies in total. The information from the employees, aggregated at the company level, was not found to be correlated with that from the employer from the same companies. Although many employers do recognise risk factors for both physical load and stress as a problem they often seem to underestimate the problem when compared with employees or their representatives. This is particularly the case for psychosocial risk factors. Also, the perception of outcome measures, especially employers who consider emotional exhaustion to be work related, were fewer than the employees' representatives of the same organisation. Preventive measures on physical load are much more popular than measures against stress. It is the responsibility of the employer to take more preventive action of all kinds. They need to recognise risk factors as problems and health outcomes to be related to work. Employees of larger companies should participate with employers to consider effective measures, and more use should be made of support at branch level. For specific preventive measures, specific predictors emerged. Except for measures to prevent work stress, information from employees did not sufficiently contribute to the initiation of preventive measures in the workplace.

  1. Higher-moment stochastic discount factor specifications and the cross-section of asset returns

    OpenAIRE

    Wang, Dengli

    2013-01-01

    The stochastic discount factor model provides a general framework for pricing assets. A suitably specified discount factor encompasses most of the theories currently in use, including the CAPM, consumption CAPM, higher-moment CAPM and their conditional versions. In this thesis, we focus on the empirical admissibility of alternative SDFs under restrictions that ensure that investors’ risk-preferences are well behaved. More innovatively, we explore whether the SDF implied by the 3 and 4-mome...

  2. Analytical Dancoff factor evaluations for reactor designs loaded with TRISO particle fuel

    International Nuclear Information System (INIS)

    Ji, Wei; Liang, Chao; Pusateri, Elise N.

    2014-01-01

    Highlights: • The Dancoff factors for randomly distributed TRISO fuel particles are evaluated. • A new “dual-sphere” model is proposed to predict Dancoff factors. • The new model accurately accounts for the coating regions of fuel particles. • High accuracy is achieved over a broad range of design parameters. • The new model can be used to analyze reactors with double heterogeneity. - Abstract: A new mathematical model, the dual-sphere model, is proposed to analytically evaluate Dancoff factors of TRISO fuel kernels based on the chord method. The accurate evaluation of fuel kernel Dancoff factors is needed when one analyzes nuclear reactors loaded with TRISO particle fuel. In these reactor designs, fuel kernels are randomly distributed and shield each other, causing a shadowing effect. The Dancoff factor is a quantitative measure of this effect and is determined by the spatial distribution of fuel kernels. A TRISO fuel particle usually consists of four layers that form a coating region outside the fuel kernel. When fuel particles are loaded in the reactor, the spatial distribution of fuel kernels can be affected by the thickness of the coating region. Therefore, the coating region should be taken into account in the calculation of Dancoff factors. However, the previous model, the single-sphere model, assumes no coating regions in the Dancoff factor predictions. To address this model deficiency, the dual-sphere model is proposed by deriving a new chord length distribution function between two fuel kernels that explicitly accounts for coating regions. The new model is employed to derive analytical solutions of infinite medium, intra-fuel pebble and intra-fuel compact/pin Dancoff factors over a wide range of volume packing fractions of TRISO fuel particles, varying from 2% to 60%. Comparisons are made with the predictions from the single-sphere model and reference Monte Carlo simulations. A significant improvement of the accuracy, over the ranges of

  3. The Higher Order Factor Structure and Gender Invariance of the Pathological Narcissism Inventory

    Science.gov (United States)

    Wright, Aidan G. C.; Lukowitsky, Mark R.; Pincus, Aaron L.; Conroy, David E.

    2010-01-01

    The Pathological Narcissism Inventory (PNI) is a recently developed multidimensional inventory for the assessment of pathological narcissism. The authors describe and report the results of two studies that investigate the higher order factor structure and gender invariance of the PNI. The results of the first study indicate that the PNI has a…

  4. Factors that Impact Quality of E-Teaching/Learning Technologies in Higher Education

    Science.gov (United States)

    Daukilas, Sigitas; Kaciniene, Irma; Vaisnoriene, Daiva; Vascila, Vytautas

    2008-01-01

    The article analyzes and assesses factors that have impact upon the quality of eTeaching/learning technologies in higher education; it is on their basis that the concept of eTeaching/learning quality is denied. Research data about the students' motives in choosing various teaching/learning technologies for the development of their competence are…

  5. Native American High School Seniors' Perceptions of Higher Education: Motivating and Demotivating Factors

    Science.gov (United States)

    Krogman, Calvin

    2013-01-01

    For many Native American students, particularly those from reservations, the pursuit of higher education is a formidable concept to grasp. Poverty, rural isolation, and a myriad of social ills all take a role as demotivational factors that act as barriers between Native American students and a college education. On the other hand, family,…

  6. Effect of Demographic Factors on E-Learning Effectiveness in a Higher Learning Institution in Malaysia

    Science.gov (United States)

    Islam, Md. Aminul; Rahim, Noor Asliza Abdul; Liang, Tan Chee; Momtaz, Hasina

    2011-01-01

    This research attempted to find out the effect of demographic factors on the effectiveness of the e-learning system in a higher learning Institution. The students from this institution were randomly selected in order to evaluate the effectiveness of learning system in student's learning process. The primary data source is the questionnaires that…

  7. Students' educational careers in Higher Education: a search into key factors regarding study outcome

    NARCIS (Netherlands)

    Dr. Cyrille A.C. Van Bragt

    2010-01-01

    Students' educational careers in Higher Education: a search into key factors regarding study outcome One of the political goals of the EU is to develop 'the most competitive knowledge-based economy in the world by 2010'. The Dutch knowledge economy faces an increased demand for highly-educated

  8. Corporate Image of Public Higher Education Institutions: Relevant Factors to Distance Learning Students

    Science.gov (United States)

    da Costa, Fabio R.; Pelissari, Anderson S.; Gonzalez, Inayara V. D. P.

    2018-01-01

    Technological advances are generating a significant increase in the supply of distance learning (DL) courses via the Internet, increasing the importance of this type of education for the university's structure. This article identifies factors associated with perceptions of the public higher education institutions' image from the perspective of DL…

  9. Intrinsic and Extrinsic Factors That Influence Black Males to Attend Institutions of Higher Education

    Science.gov (United States)

    Etheridge, Robert

    2013-01-01

    The purpose of this qualitative, narrative study was to explore the intrinsic and extrinsic factors that motivated Black males to attend institutions of higher education. The Self-determination theory and the Integrated Model for Educational Choice formed the theoretical framework for this study. Eight Black males who were between the ages of 18…

  10. Factors Affecting Corporate Image from the Perspective of Distance Learning Students in Public Higher Education Institutions

    Science.gov (United States)

    da Costa, Fábio Reis; Pelissari, Anderson Soncini

    2016-01-01

    New information technologies enable different interactions in the educational environment, affecting how the image of educational institutions adopting distance-learning programmes is perceived. This article identifies factors affecting the perception of corporate image from the viewpoint of distance-learning students at public higher education…

  11. Identifying Factors That Affect Higher Educational Achievements of Jamaican Seventh-Day Adventists

    Science.gov (United States)

    Campbell, Samuel P.

    2011-01-01

    This mixed-method explanatory research examined factors that influenced Jamaican Seventh-day Adventist (SDA) members to pursue higher education. It sought to investigate whether the source of the motivation is tied to the Church's general philosophy on education or to its overall programs as experienced by the membership at large. The question of…

  12. Factors That Influence the Diffusion Process of Mobile Devices in Higher Education in Botswana and Namibia

    Science.gov (United States)

    Asino, Tutaleni I.

    2015-01-01

    This comparative study uses the Diffusion of Innovation (DoI) theoretical framework to explore factors that influence diffusion of mobile devices in higher education in Botswana and Namibia. The five attributes (Relative Avantage, Compatability, Complexity, Trialability, and Observability) of the persuasion stage, which have been found in previous…

  13. Examining Success Factors Related to ERP Implementations in Higher Education Shared Services Projects

    Science.gov (United States)

    Stoyanoff, Dawn Galadriel Pfeiffer

    2012-01-01

    This study examined the enterprise resource planning (ERP) implementations that utilized a shared services model in higher education. The purpose of this research was to examine the critical success factors which were perceived to contribute to project success. This research employed a quantitative non-experimental correlational design and the…

  14. Contextual Factors Influencing Student Absenteeism at a Higher Education Institution in South Africa

    Science.gov (United States)

    Ramchander, Manduth

    2017-01-01

    Student absenteeism at higher education institutions (HEIs) is a cause for concern as it has implications for students' academic performance and therefore graduation rates. Graduation rates to some extent influence funding to which universities are entitled. This study aimed to establish the contextual factors that influenced student absenteeism…

  15. Women in Higher Education: Exploring Stressful Workplace Factors and Coping Strategies

    Science.gov (United States)

    Kersh, Renique

    2018-01-01

    For women administrators in higher education, workplace factors like managing multiple roles; work bleeding into personal life; issues with leadership; discrimination and marginalization; and role insufficiency (i.e., ambiguity in work roles and reduced sense of control) contribute to increased workplace stress. Individual coping responses are…

  16. Implementing Research in Professional Higher Education: Factors That Influence Lecturers' Perceptions

    Science.gov (United States)

    Griffioen, Didi M. E.; de Jong, Uulkje

    2015-01-01

    Higher professional education in Europe has changed from teaching-only institutes to hybrids of teaching and research. The purpose of this study was to examine factors that influence the judgements of lecturers about new organisational goals and perceptions of their new research-related competencies. Lecturers' judgements of new organisational…

  17. Stress-intensity factors for cracks emanating from the loaded fastener hole

    Science.gov (United States)

    Shivakumar, V.; Hsu, Y. C.

    1977-01-01

    Using a series approach and the Muskhelishvili formulation in the two-dimensional theory of elasticity, stress-intensity factors K are derived for problems in which cracks emanate radially from the boundary of an arbitrarily loaded internal circular hole in an infinite plate. Numerical values are obtained for K(I) and K(II) for radial cracks from a hole containing a loose-fitted pin or rivet that is pulled perpendicular to the crack direction in the plane of the plate. The method is a general one for determining K for a set of symmetrically emanating radial cracks for a variety of concentrated or distributed tractions on the circular hole.

  18. Autotrophic and heterotrophic nitrification-anoxic denitrification dominated the anoxic/oxic sewage treatment process during optimization for higher loading rate and energy savings.

    Science.gov (United States)

    Zhang, Xueyu; Zheng, Shaokui; Zhang, Hangyu; Duan, Shoupeng

    2018-04-30

    This study clarified the dominant nitrogen (N)-transformation pathway and the key ammonia-oxidizing microbial species at three loading levels during optimization of the anoxic/oxic (A/O) process for sewage treatment. Comprehensive N-transformation activity analysis showed that ammonia oxidization was performed predominantly by aerobic chemolithotrophic and heterotrophic ammonia oxidization, whereas N 2 production was performed primarily by anoxic denitrification in the anoxic unit. The abundances of ammonia-oxidizing bacteria (AOB), nitrite-oxidizing bacteria, and anaerobic AOB in activated sludge reflected their activities on the basis of high-throughput sequencing data. AOB amoA gene clone libraries revealed that the predominant AOB species in sludge samples shifted from Nitrosomonas europaea (61% at the normal loading level) to Nitrosomonas oligotropha (58% and 81% at the two higher loading levels). Following isolation and sequencing, the predominant culturable heterotrophic AOB in sludge shifted from Agrobacterium tumefaciens (42% at the normal loading level) to Acinetobacter johnsonii (52% at the highest loading level). Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Intellectual Leadership of Researchers in Higher Education: Relationship Between the Demographic Factors and Roles (Lithuanian Context

    Directory of Open Access Journals (Sweden)

    Žydžiūnaitė Vilma

    2016-12-01

    Full Text Available The intellectual leadership of educators or teachers represents a topic of a great interest for educational research and practice. Variety of variables or factors have been examined to find the most complete explanations for teachers’, professors’ and educators’ roles, for example, institutional, financial, gender, organizational, spiritual, and intellectual. No literature was found on the relationship between the demographic variables and researchers’ roles in higher education regarding intellectual leadership. But a lot of studies are focused on the relationship between demographic and other factors in education: job satisfaction, organizational justice, religion, gender, culture, personal and professional roles, stress, mental health, and mobility. The research issue in this study is related to researchers’/scientists’ work in higher education schools and is focused on intellectual leadership, which consists of different roles. It is worth to think about researchers as intellectual leaders and to discover how they recognize or identify their roles in higher education. In this study, findings answer the following research question: “What are the relationships between researchers’ roles and their gender, work experience, dissertation defence date, and research field?” The object of the research study is the researchers’ roles in higher education. The aim of the study was to reveal the relationship between demographic factors and researchers’ roles in higher education. Data were collected by performing a questioning survey and using a validated questionnaire with 116 statements in total. The sample consisted of 304 researchers working in higher education institutions. For data analysis, Cronbach’s alpha, Mean and ANOVA calculations were used. The research findings reported that the female-researchers’ evaluations were higher in all cases regarding their roles in higher education schools. The results of the study

  20. Factors Affecting Female Lecturer Retention in Private Higher Institution in Perak

    OpenAIRE

    Juliana Abu Bakar; Zam Zuriyati Mohamad; S.A. Sharmeela-Banu

    2015-01-01

    The contribution of female lecturer in education profession is undeniable and their satisfaction is crucial to retain them in this field. This research was conducted with the aim to investigate the factors that influence the female lecturer satisfaction in private higher education institution in Perak, Malaysia. Subsequently it intends to examine the effect of female lecturer satisfaction on their job retention. Perceived Organization Support Theory and Theory of Organizational Equilibrium ha...

  1. Intellectual Leadership of Researchers in Higher Education: Relationship Between the Demographic Factors and Roles (Lithuanian Context)

    OpenAIRE

    Žydžiūnaitė Vilma

    2016-01-01

    The intellectual leadership of educators or teachers represents a topic of a great interest for educational research and practice. Variety of variables or factors have been examined to find the most complete explanations for teachers’, professors’ and educators’ roles, for example, institutional, financial, gender, organizational, spiritual, and intellectual. No literature was found on the relationship between the demographic variables and researchers’ roles in higher education regarding inte...

  2. Factors associated with higher levels of depressive symptoms among international university students in the Philippines.

    Science.gov (United States)

    Lee, Romeo B; Maria, Madelene Sta; Estanislao, Susana; Rodriguez, Cristina

    2013-11-01

    Over the years, the number of international university students has been increasing in the Philippines. Depression tends to be common among this demographic sector, because of the varying challenges and expectations associated with studying abroad. Depression can be prevented if its symptoms, particularly those at higher levels, are identified and addressed early and effectively. This survey examined the social and demographic factors that are significantly associated with higher levels of depressive symptoms. One hundred twenty-six international university students were interviewed using the University Students Depression Inventory. Of the 13 factors analyzed, 3 were found with statistically significant associations with more intense levels of depressive symptoms. These factors were: level of satisfaction with one's financial condition, level of closeness with parents, and level of closeness with peers. In identifying international students with greater risk for depression, characteristics related to their financial condition and primary group relationships can be considered. There is a need to carry out more studies to confirm this initial evidence. The findings can help guide further discourse, research and program to benefit international students with higher levels of depressive symptoms.

  3. Personal Efficacy and Factors of Effective Learning Environment in Higher Education: Croatian and American Students

    Directory of Open Access Journals (Sweden)

    Violeta Vidaček - Hainš

    2010-06-01

    Full Text Available Successful learning in higher education incorporates various factors related to knowledge, skills, habits, and motivation. Additionally, students’ personalities and self-efficacy may contribute to their adjustment, planning of activities, and achieving success. The objective of this paper is to analyze students’ needs for support services, which enhance the effectiveness of their learning environment at higher education institutions. Answers received from a sample of undergraduate freshmen at one American University and one Croatian University were analyzed and compared. The students from both countries agree that there is a need for developing self-reliance and personal responsibility in using support services, as well as for the timely and accurate information on availability of these services. Students’ suggestions and their desire to enhance effectiveness of their learning environment may be used in creating and improving support services in higher education institutions as well as training their staff.

  4. Encouraging Factors for Invest in Higher Education in the Private Sector in Iran

    Directory of Open Access Journals (Sweden)

    Shahram Yazdani

    2017-08-01

    Full Text Available Higher education which has the main role in the training of skilled human resource can also be considered as the foundation of wealth creation in the country. The quantitative and qualitative expansion of higher education is inevitable. The facilities and the government budget are not responsive for the need, due to the increasing demand of young people for entering higher education in Iran. Therefore, developing and equipping universities and unpublicized and private higher education institutions have received considerable attention and have grown substantially. We aimed to evaluate educational experts regarding encouraging factors of the private sections for more participating in financing of higher education centers and institutions in Iran. Qualitative content analysis method has been used.The participants were selected using purposive sampling. The professors were in positions of policymaking and managing and had opinions on the challenges of universities financing. Data collection was conducted with semi-structured interview in 2016 and all ethical considerations associated with qualitative research were respected. The main concepts obtained from the interview were reported in the three main themes and their sub-classes. We have found that with the authorities given to universitiesby law, and preparing the transition from the based solely on government resources to the private section is provided by taking the appropriate decisions of managers to attract investors Universities can benefit from promoting different mechanisms to attract private financing in the higher education section. Solutions also were presented in this way. The idea of educational investment not only can promote the community investments towards higher education, but also has been the promotion of knowledge-based business in the community and promotes entrepreneurship and knowledge-based economy.Keywords: HIGHER EDUCATION, EDUCATIONAL INVESTMENT, KNOWLEDGE-BASED ECONOMY

  5. Substance and Artifact in the Higher-Order Factors of the Big Five

    Science.gov (United States)

    McCrae, Robert R.; Jang, Kerry L.; Ando, Juko; Ono, Yutaka; Yamagata, Shinji; Riemann, Rainer; Angleitner, Alois; Spinath, Frank M.

    2018-01-01

    J. M. Digman (1997) proposed that the Big Five personality traits showed a higher-order structure with 2 factors he labeled α and β. These factors have been alternatively interpreted as heritable components of personality or as artifacts of evaluative bias. Using structural equation modeling, the authors reanalyzed data from a cross-national twin study and from American cross-observer studies and analyzed new multimethod data from a German twin study. In all analyses, artifact models outperformed substance models by root-mean-square error of approximation criteria, but models combining both artifact and substance were slightly better. These findings suggest that the search for the biological basis of personality traits may be more profitably focused on the 5 factors themselves and their specific facets, especially in monomethod studies. PMID:18665712

  6. Factor 10 Visions project: Higher Education Sector Towards Sustainable Higher Education: Environmental impacts of campus-based and distance higher education systems

    OpenAIRE

    Roy, Robin; Potter, Stephen; Yarrow, Karen; Smith, Mark

    2005-01-01

    This report gives the findings of a major UK study of the environmental impacts of four different methods of providing higher education (HE) courses: Conventional campus-based full-time courses; Conventional campus-based part-time courses; Print-based distance taught courses; Part electronically-delivered distance taught courses.\\ud This is an environmental assessment of these different HE systems and does not assess their educational effectiveness or socio-economic costs and benefits.\\ud KEY...

  7. Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

    Energy Technology Data Exchange (ETDEWEB)

    Nandi, Samit K., E-mail: samitnandi1967@gmail.com [Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata (India); Kundu, Biswanath, E-mail: biswa_kundu@rediffmail.com [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India); Basu, Debabrata [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India)

    2013-04-01

    Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85 ± 2%) with wide distribution of macroporous (70–900 μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87 ± 2 and 90 ± 2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples. - Highlights: ► Fabrication and characterization of porous chitosan with or without IGF-1 and BMP-2 ► Highly porous growth factor loaded chitosan studied in animal subjects for 3 months ► Parameters studied: histopathology, radiology and fluorochrome labeling ► IGF-1 loaded porous chitosan found to be very effective for bone defect healing.

  8. Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

    International Nuclear Information System (INIS)

    Nandi, Samit K.; Kundu, Biswanath; Basu, Debabrata

    2013-01-01

    Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85 ± 2%) with wide distribution of macroporous (70–900 μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87 ± 2 and 90 ± 2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples. - Highlights: ► Fabrication and characterization of porous chitosan with or without IGF-1 and BMP-2 ► Highly porous growth factor loaded chitosan studied in animal subjects for 3 months ► Parameters studied: histopathology, radiology and fluorochrome labeling ► IGF-1 loaded porous chitosan found to be very effective for bone defect healing

  9. Switch Panel wear loading - a parametric study regarding governing train operational factors

    Science.gov (United States)

    Hiensch, E. J. M.; Burgelman, N.

    2017-09-01

    The acting forces and resulting material degradation at the running surfaces of wheels and rail are determined by vehicle, track, interface and operational characteristics. To effectively manage the experienced wear, plastic deformation and crack development at wheels and rail, the interaction between vehicle and track demands a system approach both in maintenance and in design. This requires insight into the impact of train operational parameters on rail- and wheel degradation, in particular at switches and crossings due to the complex dynamic behaviour of a railway vehicle at a turnout. A parametric study was carried out by means of vehicle-track simulations within the VAMPIRE® multibody simulation software, performing a sensitivity analysis regarding operational factors and their impact on expected switch panel wear loading. Additionally, theoretical concepts were cross-checked with operational practices by means of a case study in response to a dramatic change in lateral rail wear development at specific switches in Dutch track. Data from train operation, track maintenance and track inspection were analysed, providing further insight into the operational dependencies. From the simulations performed in this study, it was found that switch rail lateral wear loading at the diverging route of a 1:9 type turnout is significantly influenced by the level of wheel-rail friction and to a lesser extent by the direction of travel (facing or trailing). The influence of other investigated parameters, being vehicle speed, traction, gauge widening and track layout is found to be small. Findings from the case study further confirm the simulation outcome. This research clearly demonstrates the contribution flange lubrication can have in preventing abnormal lateral wear at locations where the wheel-rail interface is heavily loaded.

  10. Building and environmental factors that influence bacterial and fungal loading on air conditioning cooling coils.

    Science.gov (United States)

    Bakker, A; Siegel, J A; Mendell, M J; Peccia, J

    2018-05-30

    We investigated bacterial and fungal concentrations on cooling coils of commercial AC units and quantified associations between microbial loads and AC unit or building operational parameters. A field campaign was conducted to sample 25 AC units in the humid, subtropical climate of Southern CT, USA and 15 AC units in the hot-summer Mediterranean climate of Sacramento, CA, USA. Median concentrations (with interquartile range) of bacteria and fungi on the cooling coils were 1.2 × 10 7 (5.1 × 10 6 -3.9 × 10 7 ) cells/m 2 and 7.6 × 10 5 (5.6 × 10 4 -4.4 × 10 6 ) spore equivalents (SE)/m 2 , respectively. Concentrations varied among units with median unit concentrations ranging three orders of magnitude for bacteria and seven orders of magnitude for fungi. Controlled comparisons and multivariable regressions indicate that dominant factors associated with AC coil loading include the nominal efficiency of upstream filters (P = .008 for bacteria and P < .001 for fungi) and coil moisture, which was reflected in fungal loading differences between top and bottom halves of the AC coils in Southern CT (P = .05) and the dew points of the two climates considered (P = .04). Environmental and building characteristics explained 42% (P < .001) of bacterial concentration variability and 66% (P < .001) of fungal concentration variability among samples. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Factors identified with higher levels of career satisfaction of physicians in Andalusia, Spain

    Directory of Open Access Journals (Sweden)

    Juan Nicolás Peña-Sánchez

    2014-09-01

    Full Text Available The satisfaction of physicians is a world-wide issue linked with the quality of health services; their satisfaction needs to be studied from a multi-dimensional perspective, considering lower- and higher-order needs. The objectives of this study were to: i measure the career satisfaction of physicians; ii identify differences in the dimensions of career satisfaction; and iii test factors that affect higher- and lower-order needs of satisfaction among physicians working in Andalusian hospitals (Spain. Forty-one percent of 299 eligible physicians participated in a study conducted in six selected hospitals. Physicians reported higher professional, inherent, and performance satisfaction than personal satisfaction. Foreign physicians reported higher levels of personal and performance satisfaction than local physicians, and those who received non-monetary incentives had higher professional and performance satisfaction. In conclusion, physicians in the selected Andalusian hospitals reported low levels of personal satisfaction. Non-monetary incentives were more relevant to influence their career satisfaction. Further investigations are recommended to study differences in the career satisfaction between foreign and local physicians.

  12. Process for improving the load factor of an electricity generating power station

    International Nuclear Information System (INIS)

    Rostaing, Michel.

    1974-01-01

    A description is given of a process for improving the load factor of an electricity generating power station feeding a supply network in which all or part of the power not required by the network during off-peak hours is used for producing hydrogen which is then stored. The stored hydrogen is then burned and the heat generated is employed for superheating the steam generated by the nuclear reactor of the power plant. This combustion is carried out permanently. The hydrogen is produced by water electrolysis. The oxygen also produced in this manner is used as a comburent in the combustion of the hydrogen. The reactor is of the pressurized water type [fr

  13. Stress intensity factors of eccentric cracks in bi-materials plate under mode I loading

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, A. E. [Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor (Malaysia)

    2015-05-15

    Bi-material plates were generally used to joint electronic devices or mechanical components requiring dissimilar materials to be attached. During services, mechanical failure can be occurred due to the formation of cracks at the interfacial joint or away from the centre. Generally, linear elastic fracture mechanics approach is used to characterize these cracks based on stress intensity factors (SIF). Based on the literature survey, the SIFs for the central cracks were easily available. However, the SIFs for eccentric cracks were difficult to obtain. Therefore, this paper presented the SIFs for eccentric cracks subjected to mode I tension loading. Three important parameters were used such as relative crack depth, a/L, relative offset distance, b/L and elastic mismatch, E{sub 1}/E{sub 2} or α. It was found that such parameters significantly affected the characteristic of SIFs and it was depend on the location of cracks.

  14. Fisher Information Based Meteorological Factors Introduction and Features Selection for Short-Term Load Forecasting

    Directory of Open Access Journals (Sweden)

    Shuping Cai

    2018-03-01

    Full Text Available Weather information is an important factor in short-term load forecasting (STLF. However, for a long time, more importance has always been attached to forecasting models instead of other processes such as the introduction of weather factors or feature selection for STLF. The main aim of this paper is to develop a novel methodology based on Fisher information for meteorological variables introduction and variable selection in STLF. Fisher information computation for one-dimensional and multidimensional weather variables is first described, and then the introduction of meteorological factors and variables selection for STLF models are discussed in detail. On this basis, different forecasting models with the proposed methodology are established. The proposed methodology is implemented on real data obtained from Electric Power Utility of Zhenjiang, Jiangsu Province, in southeast China. The results show the advantages of the proposed methodology in comparison with other traditional ones regarding prediction accuracy, and it has very good practical significance. Therefore, it can be used as a unified method for introducing weather variables into STLF models, and selecting their features.

  15. Exploring item and higher order factor structure with the Schmid-Leiman solution: syntax codes for SPSS and SAS.

    Science.gov (United States)

    Wolff, Hans-Georg; Preising, Katja

    2005-02-01

    To ease the interpretation of higher order factor analysis, the direct relationships between variables and higher order factors may be calculated by the Schmid-Leiman solution (SLS; Schmid & Leiman, 1957). This simple transformation of higher order factor analysis orthogonalizes first-order and higher order factors and thereby allows the interpretation of the relative impact of factor levels on variables. The Schmid-Leiman solution may also be used to facilitate theorizing and scale development. The rationale for the procedure is presented, supplemented by syntax codes for SPSS and SAS, since the transformation is not part of most statistical programs. Syntax codes may also be downloaded from www.psychonomic.org/archive/.

  16. Toxoplasma gondii, source to sea: higher contribution of domestic felids to terrestrial parasite loading despite lower infection prevalence.

    Science.gov (United States)

    Vanwormer, Elizabeth; Conrad, Patricia A; Miller, Melissa A; Melli, Ann C; Carpenter, Tim E; Mazet, Jonna A K

    2013-09-01

    Environmental transmission of Toxoplasma gondii, a global zoonotic parasite, adversely impacts human and animal health. Toxoplasma is a significant cause of mortality in threatened Southern sea otters, which serve as sentinels for disease threats to people and animals in coastal environments. As wild and domestic felids are the only recognized hosts capable of shedding Toxoplasma oocysts into the environment, otter infection suggests land-to-sea pathogen transmission. To assess relative contributions to terrestrial parasite loading, we evaluated infection and shedding among managed and unmanaged feral domestic cats, mountain lions, and bobcats in coastal California, USA. Infection prevalence differed among sympatric felids, with a significantly lower prevalence for managed feral cats (17%) than mountain lions, bobcats, or unmanaged feral cats subsisting on wild prey (73-81%). A geographic hotspot of infection in felids was identified near Monterey Bay, bordering a high-risk site for otter infection. Increased odds of oocyst shedding were detected in bobcats and unmanaged feral cats. Due to their large populations, pet and feral domestic cats likely contribute more oocysts to lands bordering the sea otter range than native wild felids. Continued coastal development may influence felid numbers and distribution, increase terrestrial pathogens in freshwater runoff, and alter disease dynamics at the human-animal-environment interface.

  17. Employee Retention Factors For South African Higher Education Institutions: A Case Study

    Directory of Open Access Journals (Sweden)

    F. G. Netswera

    2005-11-01

    Full Text Available The success of the most competitive companies throughout the world, including higher education institutions, lies in their highly skilled employees on which these institutions spend millions to retain. Literature reveals the cost of losing best employees to be enormous – beyond monetary quantification. Also worth noting is that the loss of one competent employee to a competitor institution strengthens the competitor’s advantage. This case study analysed human resources turnover data, and interviewed academic managers and employees in order to examine the possible employee retention factors for a higher education institution in South Africa. The findings reveal different institutional interests between institutional managers and employees. The former are concerned more about profits, business sustenance and justification for spending, while the latter are driven by introverted interests such as development, monetary rewards and personal fulfilment.

  18. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis

    Directory of Open Access Journals (Sweden)

    Giovanni A. Salum

    2016-03-01

    Full Text Available Objective To investigate the validity and reliability of a multi-informant approach to measuring child maltreatment (CM comprising seven questions assessing CM administered to children and their parents in a large community sample. Methods Our sample comprised 2,512 children aged 6 to 12 years and their parents. Child maltreatment (CM was assessed with three questions answered by the children and four answered by their parents, covering physical abuse, physical neglect, emotional abuse and sexual abuse. Confirmatory factor analysis was used to compare the fit indices of different models. Convergent and divergent validity were tested using parent-report and teacher-report scores on the Strengths and Difficulties Questionnaire. Discriminant validity was investigated using the Development and Well-Being Assessment to divide subjects into five diagnostic groups: typically developing controls (n = 1,880, fear disorders (n = 108, distress disorders (n = 76, attention deficit hyperactivity disorder (n = 143 and oppositional defiant disorder/conduct disorder (n = 56. Results A higher-order model with one higher-order factor (child maltreatment encompassing two lower-order factors (child report and parent report exhibited the best fit to the data and this model's reliability results were acceptable. As expected, child maltreatment was positively associated with measures of psychopathology and negatively associated with prosocial measures. All diagnostic category groups had higher levels of overall child maltreatment than typically developing children. Conclusions We found evidence for the validity and reliability of this brief measure of child maltreatment using data from a large survey combining information from parents and their children.

  19. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis.

    Science.gov (United States)

    Salum, Giovanni A; DeSousa, Diogo Araújo; Manfro, Gisele Gus; Pan, Pedro Mario; Gadelha, Ary; Brietzke, Elisa; Miguel, Eurípedes Constantino; Mari, Jair J; do Rosário, Maria Conceição; Grassi-Oliveira, Rodrigo

    2016-01-01

    To investigate the validity and reliability of a multi-informant approach to measuring child maltreatment (CM) comprising seven questions assessing CM administered to children and their parents in a large community sample. Our sample comprised 2,512 children aged 6 to 12 years and their parents. Child maltreatment (CM) was assessed with three questions answered by the children and four answered by their parents, covering physical abuse, physical neglect, emotional abuse and sexual abuse. Confirmatory factor analysis was used to compare the fit indices of different models. Convergent and divergent validity were tested using parent-report and teacher-report scores on the Strengths and Difficulties Questionnaire. Discriminant validity was investigated using the Development and Well-Being Assessment to divide subjects into five diagnostic groups: typically developing controls (n = 1,880), fear disorders (n = 108), distress disorders (n = 76), attention deficit hyperactivity disorder (n = 143) and oppositional defiant disorder/conduct disorder (n = 56). A higher-order model with one higher-order factor (child maltreatment) encompassing two lower-order factors (child report and parent report) exhibited the best fit to the data and this model's reliability results were acceptable. As expected, child maltreatment was positively associated with measures of psychopathology and negatively associated with prosocial measures. All diagnostic category groups had higher levels of overall child maltreatment than typically developing children. We found evidence for the validity and reliability of this brief measure of child maltreatment using data from a large survey combining information from parents and their children.

  20. Factors Influencing the Organizational Stress among Teachers Working in Higher Education Sector in Kerala: An Empirical Analysis

    Science.gov (United States)

    Areekkuzhiyil, Santhosh

    2014-01-01

    The study aims to explore the various factors that influence the organizational stress of teachers working in higher education sector in the state of Kerala. The data required for the study has been conveniently collected from 200 teachers working in higher education sector. Exploratory factor analysis revealed nine factors, which significantly…

  1. The perceived influence of diversity factors on effective strategy implementation in a higher education institution

    Directory of Open Access Journals (Sweden)

    K. Strydom

    2018-04-01

    Full Text Available Managing diversity is one of the major challenges in higher education institutions in South Africa. Additionally, effective strategy implementation is vital for an institution to be successful and sustainable. Questionnaires were distributed to the management of Walter Sisulu University, South Africa, to investigate the relationship between diversity factors and effective strategy implementation. The questionnaires interrogated the effect of the acculturation process, the degree of structural integration, the degree of informal integration, institutional bias and intergroup conflict, and how these factors influence strategy implementation. Structural equation modelling (SEM was employed as the statistical tool to confirm the hypothetical model. Results of this study revealed that there is no statistically significant relationship between diversity and strategy implementation at the institution, and imply that diversity among staff do not impact on the successful achievement of strategic objectives in the institution. The findings of the study are contrary to empirical evidence by other studies. Keywords: Education, Sociology, Political science, Psychology

  2. Human Factors Evaluation of the Modular Lightweight Load-Carrying Equipment (MOLLE) System

    National Research Council Canada - National Science Library

    Sampson, James

    2001-01-01

    .... The FEA was used in drafting a new user requirements document and initiating the development of a modular load-carrying system which ultimately became known as the Modular Lightweight Load-carrying Equipment (MOLLE...

  3. Factors for Successful Use of Social Networking Sites in Higher Education

    Directory of Open Access Journals (Sweden)

    L Schlenkrich

    2012-09-01

    Full Text Available Social networking sites are extremely popular online destinations that offer users easy ways to build and maintain relationships with each other, and to disseminate information in an activity referred to as social networking. Students, lecturers, teachers, parents and businesses, in increasing numbers, use tools available on social networking sites to communicate with each other in a fast and cost-effective manner. The use of social networking sites to support educational initiatives has received much attention. However, the full potential of social network sites has yet to be achieved as users continue to strive for optimal ways of using these sites, as well as battle to overcome the negative characteristics (for example, privacy, security, governance, user behaviour, information quality of these sites. This paper proposes factors for successful use of social networking sites in higher educational institutions. These success factors need to be adopted by users in order to develop the positive aspects of social networking, while at the same time mitigating the negative characteristics. An initial set of factors for successful use of social networking sites, as well as measures to test successful use of social networking sites were derived from the literature. These factors were tested by means of an online survey of students at a university, the results of which informed the final factors for successful use of social networking sites. The factors enable users to overcome the negative characteristics associated with social networking sites. If used successfully, social networking sites can offer lecturers and students a useful tool with which to develop their relationship and contribute to their learning experience.

  4. Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen

    Directory of Open Access Journals (Sweden)

    Junmin Lai

    2017-02-01

    Full Text Available The aim of the study was to investigate the effects of the loading factors, i.e., the initial drug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical performance of drug-loaded mesoporous systems. Ibuprofen (IBU was used as a model drug, and two non-ordered mesoporous materials of commercial silica Syloid® 244FP (S244FP and Neusilin® US2 (NS2 were selected in the study. The IBU-loaded mesoporous samples were prepared by a solvent immersion method with a rotary evaporation drying technique and characterized by polarized light microscopy (PLM, Fourier transform infrared (FTIR spectroscopy, X-ray powder diffraction (XRPD and differential scanning calorimetry (DSC. Dissolution experiments were performed in simulated gastric media at 37 °C under non-sink conditions. The concentration of IBU in solution was determined by HPLC. The study showed that the dissolution rate of IBU can be improved significantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into the amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the molecular interaction between the IBU and NS2 carriers, the loading factors had little effects on the drug release kinetics with incomplete drug desorption recovery and insignificant dissolution enhancement. Care and extensive evaluation must therefore be taken when mesoporous materials are chosen as carrier delivery systems.

  5. Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load.

    Science.gov (United States)

    Attonito, Jennifer; Dévieux, Jessy G; Lerner, Brenda D G; Hospital, Michelle M; Rosenberg, Rhonda

    2014-01-01

    Psychosocial factors may directly impact HIV health measures such as viral load (VL) whether or not patients are taking antiretroviral treatment (ART) consistently. Structural equation modeling plus Baron and Kenny's (1986) four-step approach were used to test a mediated model predicting VL among 246 HIV-infected adults who were on ART. Exogenous variables were social support, barriers to adherence, and stress. Moderators were alcohol use, marijuana use, and neurocognitive impairment. A small positive association between marijuana use and ART adherence approached significance. Only barriers to adherence predicted a decrease in adherence rates and an increase in VL. No other factors were significantly associated with either VL or adherence, and no interaction effects between exogenous variables and moderators were identified. The association between barriers to adherence and VL was partially mediated by ART adherence. Findings provide modest support for a direct link between psychosocial variables and a virologic response to ART. Copyright © 2014 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

  6. Influential Factors for Accurate Load Prediction in a Demand Response Context

    DEFF Research Database (Denmark)

    Wollsen, Morten Gill; Kjærgaard, Mikkel Baun; Jørgensen, Bo Nørregaard

    2016-01-01

    Accurate prediction of a buildings electricity load is crucial to respond to Demand Response events with an assessable load change. However, previous work on load prediction lacks to consider a wider set of possible data sources. In this paper we study different data scenarios to map the influence....... Next, the time of day that is being predicted greatly influence the prediction which is related to the weather pattern. By presenting these results we hope to improve the modeling of building loads and algorithms for Demand Response planning.......Accurate prediction of a buildings electricity load is crucial to respond to Demand Response events with an assessable load change. However, previous work on load prediction lacks to consider a wider set of possible data sources. In this paper we study different data scenarios to map the influence...

  7. Factorization and resummation: A new paradigm to improve gravitational wave amplitudes. II. The higher multipolar modes

    Science.gov (United States)

    Messina, Francesco; Maldarella, Alberto; Nagar, Alessandro

    2018-04-01

    The factorization and resummation approach of Nagar and Shah [Phys. Rev. D 94, 104017 (2016), 10.1103/PhysRevD.94.104017], designed to improve the strong-field behavior of the post-Newtonian (PN) residual waveform amplitudes fℓm's entering the effective-one-body, circularized, gravitational waveform for spinning coalescing binaries, is improved and generalized here to all multipoles up to ℓ=6 . For a test particle orbiting a Kerr black hole, each multipolar amplitude is truncated at relative 6 PN order, both for the orbital (nonspinning) and spin factors. By taking a certain Padé approximant (typically the P24 one) of the orbital factor in conjunction with the inverse Taylor (iResum) representation of the spin factor, it is possible to push the analytical/numerical agreement of the energy flux at the level of 5% at the last-stable orbit for a quasimaximally spinning black hole with dimensionless spin parameter +0.99 . When the procedure is generalized to comparable-mass binaries, each orbital factor is kept at relative 3+3 PN order; i.e., the globally 3 PN-accurate comparable-mass terms are hybridized with higher-PN test-particle terms up to 6 PN relative order in each mode. The same Padé resummation is used for continuity. By contrast, the spin factor is only kept at the highest comparable-mass PN order currently available. We illustrate that the consistency between different truncations in the spin content of the waveform amplitudes is more marked in the resummed case than when using the standard Taylor-expanded form of Pan et al. [Phys. Rev. D 83, 064003 (2011), 10.1103/PhysRevD.83.064003]. We finally introduce a method to consistently hybridize comparable-mass and test-particle information also in the presence of spin (including the spin of the particle), discussing it explicitly for the ℓ=m =2 spin-orbit and spin-square terms. The improved, factorized and resummed, multipolar waveform amplitudes presented here are expected to set a new standard for

  8. Factors related to external loads in buried pipelines; Consideracoes quanto as variaveis relacionadas ao carregamento externo em dutos enterrados

    Energy Technology Data Exchange (ETDEWEB)

    Provenzano, Carlos E.C.; Silva, Breno S.; Fernandes, Lincoln F.; Santos Junior, Sergio J.F. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Louzada, Carlos H.C.M.

    2005-07-01

    Work of heavy equipment or vehicles above existent right-of-ways, may cause undesired external overload at buried pipelines in operation. The effect of these loads shall be analyzed considering the deflections and stresses on the pipelines. The major variables, nominal diameter, thickness, material, soil parameters, operation pressure and external loads shall be related and verified according to the limits from original project. Cases when the external loads cause higher efforts, the traffic over the pipelines shall be restricted in order to avoid damages. In other cases, it may be adapted to any technical alternatives to modify the parameters in such a way to make possible work above the right-of-way, such as increase the machine support area, increase backfill covering, a reduction in the internal operation pressure in a short time, etc. This work presents the study on the parameters used to establish the maximum allowable external loads over buried pipelines in operation. (author)

  9. Form factors and complete spectrum of XXX antiperiodic higher spin chains by quantum separation of variables

    Energy Technology Data Exchange (ETDEWEB)

    Niccoli, G. [YITP, Stony Brook University, New York 11794-3840 (United States)

    2013-05-15

    The antiperiodic transfer matrices associated to higher spin representations of the rational 6-vertex Yang-Baxter algebra are analyzed by generalizing the approach introduced recently in the framework of Sklyanin's quantum separation of variables (SOV) for cyclic representations, spin-1/2 highest weight representations, and also for spin-1/2 representations of the 6-vertex reflection algebra. Such SOV approach allow us to derive exactly results which represent complicate tasks for more traditional methods based on Bethe ansatz and Baxter Q-operator. In particular, we both prove the completeness of the SOV characterization of the transfer matrix spectrum and its simplicity. Then, the derived characterization of local operators by Sklyanin's quantum separate variables and the expression of the scalar products of separate states by determinant formulae allow us to compute the form factors of the local spin operators by one determinant formulae similar to those of the scalar products.

  10. Choosing to lead the motivational factors of underrepresented minority librarians in higher education

    CERN Document Server

    Olivas, Antonia

    2017-01-01

    Choosing to Lead: The Motivational Factors of Underrepresented Minority Librarians in Higher Education takes a positive inquiry approach by providing first-hand accounts of success stories, best practices, and practical advice from a collection of diverse authors. Instead of looking at academic library "failures" when it comes to diversifying the leadership workforce, this book highlights what's going right and how to implement it across the profession-with an emphasis on building strengths and fully leveraging one's interests, behaviors, and passions, while never ignoring or deemphasizing the prevailing challenges that exist for diverse LIS professionals who wish to advance their leadership skills. Through case studies, promising practices, and specific strategies for cultivating diversity in academic library leadership, this is a resource for both librarians of color who wish to seek leadership positions and current library leaders who want to nurture these future leaders.

  11. Floodplain methylmercury biomagnification factor higher than that of the contiguous river (South River, Virginia USA)

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Michael C., E-mail: newman@vims.edu [College of William and Mary - VIMS, P.O. Box 1346, Rt. 1208 Greate Rd., Gloucester Point, VA 23062 (United States); Xu Xiaoyu, E-mail: xiaoyu@vims.edu [College of William and Mary - VIMS, P.O. Box 1346, Rt. 1208 Greate Rd., Gloucester Point, VA 23062 (United States); Condon, Anne, E-mail: anne_condon@fws.gov [U.S. Fish and Wildlife, 6669 Short Lane, Gloucester, VA 23061 (United States); Liang Lian, E-mail: liang@cebam.net [Cebam Analytical, Inc., 18804 North Creek Parkway, Suite 110, Bothell, WA 98011 (United States)

    2011-10-15

    Mercury biomagnification on the South River floodplain (Virginia, USA) was modeled at two locations along a river reach previously modeled for methylmercury movement through the aquatic trophic web. This provided an opportunity to compare biomagnification in adjoining trophic webs. Like the aquatic modeling results, methylmercury-based models provided better prediction than those for total mercury. Total mercury Food Web Magnification Factors (FWMF, fold per trophic level) for the two locations were 4.9 and 9.5. Methylmercury FWMF for the floodplain locations were higher (9.3 and 25.1) than that of the adjacent river (4.6). Previous speculation was not resolved regarding whether the high mercury concentrations observed in floodplain birds was materially influenced by river prey consumption by riparian spiders and subsequent spider movement into the trophic web of the adjacent floodplains. Results were consistent with a gradual methylmercury concentration increase from contaminated floodplain soil, to arthropod prey, and finally, to avian predators. - Highlights: > First comparison of methylmercury biomagnification in adjacent river/land food webs. > Methylmercury increased more rapidly in the terrestrial, than the aquatic, food web. > Methylmercury increased gradually from soil, to prey, and, to avian predators. - Higher methylmercury biomagnification on South River floodplain than the associated river likely explain high mercury in floodplain birds.

  12. Utilization of Plutonium and Higher Actinides in the HTGR as Possibility to Maintain Long-Term Operation on One Fuel Loading

    International Nuclear Information System (INIS)

    Tsvetkova, Galina V.; Peddicord, Kenneth L.

    2002-01-01

    Promising existing nuclear reactor concepts together with new ideas are being discussed worldwide. Many new studies are underway in order to identify prototypes that will be analyzed and developed further as systems for Generation IV. The focus is on designs demonstrating full inherent safety, competitive economics and proliferation resistance. The work discussed here is centered on a modularized small-size High Temperature Gas-cooled Reactor (HTGR) concept. This paper discusses the possibility of maintaining long-term operation on one fuel loading through utilization of plutonium and higher actinides in the small-size pebble-bed reactor (PBR). Acknowledging the well-known flexibility of the PBR design with respect to fuel composition, the principal limitations of the long-term burning of plutonium and higher actinides are considered. The technological challenges and further research are outlined. The results allow the identification of physical features of the PBR that significantly influence flexibility of the design and its applications. (authors)

  13. Governance of the research activities in higher educational institutions: factors and outcomes

    Directory of Open Access Journals (Sweden)

    Musawenkosi Ngibe

    2016-07-01

    Full Text Available South African higher education institutions, specifically, universities of technology have been faced with an arduous battle of increasing postgraduate students enrolment (masters and doctoral and improve their completion rate. However, the situation is exacerbated by inadequate number and inexperience of supervisors to supervise these postgraduate students. The Durban University of Technology has formulated research structures to administer and co-ordinate research activities in order to improve the number of staff members with doctoral qualifications in order to aid the current challenges. Therefore, the aim of this study is to evaluate the circumstances and factors hindering the academic staff throughput rates and the impact it has on the university. The use of qualitative and quantitative approach was used for this study, with closed and open-ended questionnaires used to collect data from 278 academic staff members using a probability sampling. The respondents 9 (4.9% indicated that lack of external funding and project management skills proved to be major contributory factors hindering academics staff to complete their postgraduate degrees within the required time. The study recommends that funding should be made easily available to academics pursuing doctoral studies, while project management workshops should be organised regularly to help academics appropriately management their studies. This can have a positive impact which will benefit the university and aid to the current crisis of lack of supervisor for masters and doctoral studies

  14. Factors relating to the attraction of talented early career academics in South African higher education institutions

    Directory of Open Access Journals (Sweden)

    Dorcas L. Lesenyeho

    2018-06-01

    Full Text Available Orientation: South African higher education institutions (HEIs are facing significant challenges in attracting talents to academic positions. Research purpose: The main objective of this research was to determine factors that will attract early career academics to South African HEIs. Motivation for the study: Currently there exists limited research on factors that attract early career academics to HEIs as preferred employers. Research approach, design and method: A qualitative approach was adopted for this study; semi-structured interviews were conducted to gain data. The study participants comprised of 23 academic staff members from various merged South African HEIs. Main findings: The findings show that nine themes are related to the attraction of early career academics to HEIs: career development and advancement, opportunities to make a contribution, employer branding and prestige, job security, flexible working hours (work–life balance, intellectual stimulation, innovation, opportunity to apply skills and autonomy. Practical/managerial implications: The results also challenge HEIs to develop a superior employer brand with a strong employee value proposition (EVP that would attract, develop and reward early career academics for their work efforts. Contribution/value-add: The study provides important practical guidelines that could assist HEIs to attract talented early career academics and become an employer of choice.

  15. Nearshore hydrodynamics as loading and forcing factors for Escherichia coli contamination at an embayed beach

    Science.gov (United States)

    Ge, Zhongfu; Whitman, Richard L.; Nevers, Meredith B.; Phanikumar, Mantha S.; Byappanahalli, Muruleedhara N.

    2012-01-01

    Numerical simulations of the transport and fate of Escherichia coli were conducted at Chicago's 63rd Street Beach, an embayed beach that had the highest mean E. coli concentration among 23 similar Lake Michigan beaches during summer months of 2000-2005, in order to find the cause for the high bacterial contamination. The numerical model was based on the transport of E. coli by current circulation patterns in the embayment driven by longshore main currents and the loss of E. coli in the water column, taking settling as well as bacterial dark- and solar-related decay into account. Two E. coli loading scenarios were considered: one from the open boundary north of the embayment and the other from the shallow water near the beachfront. Simulations showed that the embayed beach behaves as a sink for E. coli in that it generally receives E. coli more efficiently than it releases them. This is a result of the significantly different hydrodynamic forcing factors between the inside of the embayment and the main coastal flow outside. The settled E. coli inside the embayment can be a potential source of contamination during subsequent sediment resuspension events, suggesting that deposition-resuspension cycles of E. coli have resulted in excessive bacterial contamination of beach water. A further hypothetical case with a breakwater shortened to half its original length, which was anticipated to enhance the current circulation in the embayment, showed a reduction in E. coli concentrations of nearly 20%.

  16. Evaluation of Dynamic Load Factors for a High-Speed Railway Truss Arch Bridge

    Directory of Open Access Journals (Sweden)

    Ding Youliang

    2016-01-01

    Full Text Available Studies on dynamic impact of high-speed trains on long-span bridges are important for the design and evaluation of high-speed railway bridges. The use of the dynamic load factor (DLF to account for the impact effect has been widely accepted in bridge engineering. Although the field monitoring studies are the most dependable way to study the actual DLF of the bridge, according to previous studies there are few field monitoring data on high-speed railway truss arch bridges. This paper presents an evaluation of DLF based on field monitoring and finite element simulation of Nanjing DaShengGuan Bridge, which is a high-speed railway truss arch bridge with the longest span throughout the world. The DLFs in different members of steel truss arch are measured using monitoring data and simulated using finite element model, respectively. The effects of lane position, number of train carriages, and speed of trains on DLF are further investigated. By using the accumulative probability function of the Generalized Extreme Value Distribution, the probability distribution model of DLF is proposed, based on which the standard value of DLF within 50-year return period is evaluated and compared with different bridge design codes.

  17. Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A

    Science.gov (United States)

    Lee, Hyun Woong; Chang, Dong-Yeop; Moon, Hong Ju; Chang, Hye Young; Shin, Eui-Cheol; Lee, June Sung; Kim, Kyung-Ah; Kim, Hyung Joon

    2015-01-01

    Background and Aims Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, and clinical outcomes in patients with acute hepatitis A (AHA) and evaluated predictive factors for severe acute hepatitis (s-AH). Methods We analyzed the clinical manifestations of AHA in 770 patients. Patients with a prothrombin time (PT) of less than 40% of normal were classified as s-AH and included 4 patients with FHF, 11 patients with acute renal failure, and 3 patients with prolonged jaundice (n = 128). Other patients were defined as mild acute hepatitis (m-AH) (n = 642). Serum samples were obtained from 48 patients with acute hepatitis A. Among them, 20 with s-AH, and 28 with m-AH, were tested for HAV RNA titer. Results In a multivariate analysis, age (HR = 1.042, P = 0.041), peak creatinine (HR = 4.014, P = 0.001), bilirubin (HR = 1.153, P = 0.003), alanine aminotransferase (ALT) (HR = 1.001, Phepatitis A. PMID:26090677

  18. Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A.

    Science.gov (United States)

    Lee, Hyun Woong; Chang, Dong-Yeop; Moon, Hong Ju; Chang, Hye Young; Shin, Eui-Cheol; Lee, June Sung; Kim, Kyung-Ah; Kim, Hyung Joon

    2015-01-01

    Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, and clinical outcomes in patients with acute hepatitis A (AHA) and evaluated predictive factors for severe acute hepatitis (s-AH). We analyzed the clinical manifestations of AHA in 770 patients. Patients with a prothrombin time (PT) of less than 40% of normal were classified as s-AH and included 4 patients with FHF, 11 patients with acute renal failure, and 3 patients with prolonged jaundice (n = 128). Other patients were defined as mild acute hepatitis (m-AH) (n = 642). Serum samples were obtained from 48 patients with acute hepatitis A. Among them, 20 with s-AH, and 28 with m-AH, were tested for HAV RNA titer. In a multivariate analysis, age (HR = 1.042, P = 0.041), peak creatinine (HR = 4.014, P = 0.001), bilirubin (HR = 1.153, P = 0.003), alanine aminotransferase (ALT) (HR = 1.001, P hepatitis A.

  19. Factors associated with staff development processes and the creation of innovative science courses in higher education

    Science.gov (United States)

    Hodges, Jeanelle Bland

    1999-11-01

    The purpose of the study was to determine factors associated with staff development processes and the creation of innovative science courses by higher education faculty who have participated in a model staff development project. The staff development program was designed for college faculty interested in creating interdisciplinary, constructivist-based science, mathematics, or engineering courses designed for non-majors. The program includes workshops on incorporating constructivist pedagogy, alternative assessment, and technology into interdisciplinary courses. Staff development interventions used in the program include grant opportunities, distribution of resource materials, and peer mentoring. University teams attending the workshops are comprised of faculty from the sciences, mathematics, or engineering, as well as education, and administration. A purposeful and convenient sample of three university teams were subjects for this qualitative study. Each team had attended a NASA Opportunities for Visionary Academics (NOVA) workshop, received funding for course development, and offered innovative courses. Five questions were addressed in this study: (a) What methods were used by faculty teams in planning the courses? (b) What changes occurred in existing science courses? (c) What factors affected the team collaboration process? (d) What personal characteristics of faculty members were important in successful course development? and (e) What barriers existed for faculty in the course development process? Data was collected at each site through individual faculty interviews (N = 11), student focus group interviews (N = 15), and classroom observations. Secondary data included original funding proposals. The NOVA staff development model incorporated effective K--12 interventions with higher education interventions. Analysis of data revealed that there were four factors of staff development processes that were most beneficial. First, the team collaborative processes

  20. Dutch monitor on stress and physical load : risk factors, consequences, and preventive action

    NARCIS (Netherlands)

    Houtman, I.L.D.; Goudswaard, A.; Dhondt, S.; Grinten, M.P. van der; Hildebrandt, V.H.; Poel, E.G.T. van der

    1998-01-01

    Objectives - Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks,

  1. Stress concentration factors for integral and pad reinforced nozzles in spherical pressure vessels subjected to radial load and moment

    International Nuclear Information System (INIS)

    Soliman, S.F.; Gill, S.S.

    1979-01-01

    Charts are presented giving the elastic stress concentration factors in spherical pressure vessels with pad and integral reinforcement for radial branches subjected to radial load and moment. The effect of all the geometrical parameters is discussed, including the limitations of thin shell theory on the validity of the results. (author)

  2. Reliability Analysis of Offshore Jacket Structures with Wave Load on Deck using the Model Correction Factor Method

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Friis-Hansen, P.; Nielsen, J.S.

    2006-01-01

    failure/collapse of jacket type platforms with wave in deck loads using the so-called Model Correction Factor Method (MCFM). A simple representative model for the RSR measure is developed and used in the MCFM technique. A realistic example is evaluated and it is seen that it is possible to perform...

  3. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect

    Directory of Open Access Journals (Sweden)

    Lucia Montenegro

    2017-12-01

    Full Text Available Lipid nanocarriers show occlusive properties that may be related to their ability to improve skin hydration. The aim of this work was to evaluate the relationship between in vitro occlusion factor and in vivo skin hydration for three types of lipid nanocarriers: nanoemulsions (NEs, solid lipid nanoparticles (SLNs and nanostructured lipid carriers (NLCs. These lipid nanocarriers were loaded with trans-resveratrol (RSV and incorporated in gel vehicles. In vitro occlusion factor was in the order SLNs > NLCs > NEs. Gels containing unloaded or RSV loaded lipid nanocarriers were applied on the back of a hand of 12 healthy volunteers twice a day for one week, recording skin hydration changes using the instrument Soft Plus. An increase of skin hydration was observed for all lipid nanocarriers (SLNs > NLCs > NEs. RSV loading into these nanocarriers did not affect in vitro and in vivo lipid nanocarriers effects. A linear relationship (r2 = 0.969 was observed between occlusion factor and in vivo increase of skin hydration. Therefore, the results of this study showed the feasibility of using the occlusion factor to predict in vivo skin hydration resulting from topical application of different lipid nanocarriers loading an active ingredient with no inherent hydrating activity.

  4. CHANGES IN HIGHER EDUCATION: A COMPARISON OF KEY FACTORS CONCERNING UNIVERSITIES IN AUSTRIA AND SWITZERLAND

    Directory of Open Access Journals (Sweden)

    Robert Rybnicek

    2016-10-01

    Full Text Available Society has changed sustainably and universities have thus faced new requirements. As a result of competition and globalization, education and knowledge management had to be adapted. Universities were forced to establish a modern management system primarily known from the private sector and governments had to reconsider their legal and economic relationship to universities. In recent years, many countries have implemented new rules for their universities. Two of these countries were Austria and Switzerland. But even when they pursued the same goals, they have chosen quite different approaches and as a matter of fact achieved very differing results. The objective of this study was twofold. Firstly, we analyzed the challenges and contradictions when implementing a modern university model. Secondly, we investigated specific characteristics of the university systems of Austria and Switzerland to identify factors that may have impacted the performance and success of the universities. Referring to our first objective, a literature review has revealed severe contradictions between modern university management and the traditional understanding of it. While the traditional scheme has focused mainly on research, teaching is becoming more relevant in the new demand orientated university. Also, the freedom of science and teaching is limited by the strong orientation on goals that have been agreed upon with the government. Further contradictions can be identified in autonomy, budgeting, leadership, hierarchy, and employee participation. To examine the second research aim, we reviewed national and international databases and reports. Our results emphasize the importance of monetary aspects, the student-teacher-ratio, autonomy, and the relevance of the universities’ reputation and acceptance within society and politics. Our findings can help to understand the different approaches which have been chosen to cope with global changes in higher education. They

  5. Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load

    Directory of Open Access Journals (Sweden)

    Ana Júlia Luz

    Full Text Available OBJECTIVE: To evaluate the factors associated with plasma concentrations of atazanavir (ATV in a cohort of well-controlled HIV infected subjects (undetectable viremia. Design: Cross-sectional study where 69 subjects were consecutively enrolled between April and November, 2011. METHODS: Patients had to be on atazanavir for at least six months, undetectable viral load for a period equal to or longer than 12 months, T CD4+ lymphocyte count higher than 200 cells/mm³, and aged between 18 years and 70 years old. Exclusion criteria were pregnancy, any neurologic disease, active opportunistic disease, hepatitis or cancer. Atazanavir plasma levels were measured by ultra-performance liquid chromatography. RESULTS AND DISCUSSION: Overall, 54 patients (mean age of 47 years and 50% women were included in the analysis. Those without ritonavir (unboosted atazanavir had statistically lower plasma concentrations than those with ritonavir boosted atazanavir (p = 0.001 and total and indirect bilirubin were statistically associated with plasma concentration of atazanavir (r = 0.32 and r = 0.33 respectively; p < 0.05 in both cases. no statistical association was found among gender, ethnicity, age, weight, body mass index (BMI, lipid profile, and the plasma concentration of atazanavir. CONCLUSION: in summary, as expected, concomitant ritonavir use was the only factor associated with atazanavir plasma levels. prospective studies with a larger sample size might help to observe an association of atazanavir concentrations to other characteristics such as body weight, since the p-value showed to be close to significance (p = 0.068.

  6. Session-RPE Method for Training Load Monitoring: Validity, Ecological Usefulness, and Influencing Factors

    Directory of Open Access Journals (Sweden)

    Monoem Haddad

    2017-11-01

    Full Text Available Purpose: The aim of this review is to (1 retrieve all data validating the Session-rating of perceived exertion (RPE-method using various criteria, (2 highlight the rationale of this method and its ecological usefulness, and (3 describe factors that can alter RPE and users of this method should take into consideration.Method: Search engines such as SPORTDiscus, PubMed, and Google Scholar databases in the English language between 2001 and 2016 were consulted for the validity and usefulness of the session-RPE method. Studies were considered for further analysis when they used the session-RPE method proposed by Foster et al. in 2001. Participants were athletes of any gender, age, or level of competition. Studies using languages other than English were excluded in the analysis of the validity and reliability of the session-RPE method. Other studies were examined to explain the rationale of the session-RPE method and the origin of RPE.Results: A total of 950 studies cited the Foster et al. study that proposed the session RPE-method. 36 studies have examined the validity and reliability of this proposed method using the modified CR-10.Conclusion: These studies confirmed the validity and good reliability and internal consistency of session-RPE method in several sports and physical activities with men and women of different age categories (children, adolescents, and adults among various expertise levels. This method could be used as “standing alone” method for training load (TL monitoring purposes though some recommend to combine it with other physiological parameters as heart rate.

  7. Determination of the usage factor of components after cyclic loading by means of high-resolution microstructural examination

    International Nuclear Information System (INIS)

    Seibold, A.; Scheibe, A.; Assmann, H.D.

    1991-01-01

    Materials subjected to cyclic loading experience a change in the microstructure which may affect the service life. Quantification of the microstructural changes and allocation of the microstructural condition to the corresponding point on the fatigue curve for the component material allows the usage factor to be derived. Taking the low-alloy, fine-grained structural steel 20MnMoNi55 (quenched and tempered structure) as an example, the relationship between microstructure and number of load cycles can be represented in the form of a reference curve. High-resolution examination allows the usage factor to be determined up to η=N/N f ≅0.5 under the given cyclic loading. Only a small specimen volume is required for examination using a transmission electron microscope. It can be taken from the component without affecting the required minimum wall thickness. The location of the specimen must, however, be stipulated, e.g. the location of highest loading according to calculations. When removing the specimen, care must be taken to ensure that the micro-structure is not affected. If these requirements are observed, high-resolution microstructural examination provides a method for checking the usage factor of a component. (orig.)

  8. Embedded data collector (EDC) phase II load and resistance factor design (LRFD) : [summary].

    Science.gov (United States)

    2015-07-01

    Piles that support bridge structures are designed for the specific site characteristics and loads : that the piles are expected to bear. In Florida, driven piles are monitored during installation : (dynamically tested) to assess resistance, com...

  9. Influence of load type on power factor and harmonic composition of three-phase rectifier current

    Science.gov (United States)

    Nikolayzin, N. V.; Vstavskaya, E. V.; Konstantinov, V. I.; Konstantinova, O. V.

    2018-05-01

    This article is devoted to research of the harmonic composition of the three-phase rectifier current consumed when it operates with different types of load. The results are compared with Standard requirements.

  10. Risk factors and long-term outcomes of pediatric liver transplant recipients with chronic high Epstein-Barr virus loads.

    Science.gov (United States)

    Kamei, Hideya; Ito, Yoshinori; Kawada, Junichi; Ogiso, Satoshi; Onishi, Yasuharu; Komagome, Masahiko; Kurata, Nobuhiko; Ogura, Yasuhiro

    2018-04-20

    Serial monitoring of Epstein-Barr virus (EBV) reveals that certain pediatric liver transplant (LT) recipients exhibit high EBV loads for long periods. We investigated the incidence and risk factors of chronic high EBV (CHEBV) loads (continuous EBV DNA >10 000 IU/mL of whole blood for ≥6 months) and long-term outcomes. This single center, retrospective observational study investigated pediatric LT recipients who survived ≥6 months. We quantitated EBV DNA weekly during hospitalization and subsequently every 4 or 6 weeks at the outpatient clinic. Tacrolimus was maintained at a low trough level (5000 IU/mL). Thirty-one of 77 LT recipients developed CHEBV. Univariate analysis revealed that age 35 minutes, graft-to-recipient weight ratio (GRWR) >2.7%, and preoperative EBV seronegativity were significantly associated with the development of CHEBV loads. Multivariate analysis identified significant associations of CHEBV with WIT >35 minutes, GRWR >2.7%, and preoperative seronegative. None of the recipients developed post-transplantation lymphoproliferative disorder. Survival rates of patients with and without CHEBV loads were not significantly different. A significant number of pediatric LT recipients developed CHEBV loads. Long WIT, high GRWR, and preoperative EBV seronegativity were significantly associated with the development of CHEBV loads. Although the long-term outcomes of patients with or without CHEBV loads were not significantly different, further studies of more subjects are warranted. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Hierarchy of factors exerting an impact on nutrient load of the Baltic Sea and sustainable management of its drainage basin.

    Science.gov (United States)

    Kiedrzyńska, Edyta; Jóźwik, Adam; Kiedrzyński, Marcin; Zalewski, Maciej

    2014-11-15

    The aim of the paper was to evaluate 23 catchment factors that determine total phosphorus and total nitrogen load to the Baltic Sea. Standard correlation analysis and clustering were used. Both phosphorus and nitrogen loads were found to be positively related to the number of pigs and the human population associated with wastewater treatment plants (WWTPs) per km(2), while the number of cattle and agricultural area were found to influence nitrogen rather than phosphorus load, and the area of forests is negatively related to loads of both nutrients. Clustering indicates an overall north-south pattern in the spatial co-occurrence of socio-ecological factors, with some exceptions discussed in the paper. Positive steps in the Baltic Sea region have already been taken, but much remains to be done. The development of coherent response policies to reduce eutrophication in the Baltic Sea should be based on a comprehensive knowledge base, an appropriate information strategy and learning alliance platform in each drainage river catchments. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Enhancement of skin wound healing with decellularized scaffolds loaded with hyaluronic acid and epidermal growth factor

    Energy Technology Data Exchange (ETDEWEB)

    Su, Zhongchun; Ma, Huan; Wu, Zhengzheng [Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Jinan University, Guangzhou 510632 (China); Zeng, Huilan [Department of Hematology, The First Affiliated Hospital, Jinan University, Guangzhou 510632 (China); Li, Zhizhong [Department of Bone, The First Affiliated Hospital, Jinan University, Guangzhou 510632 (China); Wang, Yuechun; Liu, Gexiu [Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632 (China); Xu, Bin; Lin, Yongliang; Zhang, Peng [Grandhope Biotech Co., Ltd., Building D, #408, Guangzhou International Business Incubator, Guangzhou Science Park, Guangzhou 510663, Guangdong (China); Wei, Xing, E-mail: wei70@hotmail.com [Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Jinan University, Guangzhou 510632 (China)

    2014-11-01

    Current therapy for skin wound healing still relies on skin transplantation. Many studies were done to try to find out ways to replace skin transplantation, but there is still no effective alternative therapy. In this study, decellularized scaffolds were prepared from pig peritoneum by a series of physical and chemical treatments, and scaffolds loaded with hyaluronic acid (HA) and epidermal growth factor (EGF) were tested for their effect on wound healing. MTT assay showed that EGF increased NIH3T3 cell viability and confirmed that EGF used in this study was biologically active in vitro. Scanning electron microscope (SEM) showed that HA stably attached to scaffolds even after soaking in PBS for 48 h. ELISA assay showed that HA increased the adsorption of EGF to scaffolds and sustained the release of EGF from scaffolds. Animal study showed that the wounds covered with scaffolds containing HA and EGF recovered best among all 4 groups and had wound healing rates of 49.86%, 70.94% and 87.41% respectively for days 10, 15 and 20 post-surgery compared to scaffolds alone with wound healing rates of 29.26%, 42.80% and 70.14%. In addition, the wounds covered with scaffolds containing EGF alone were smaller than no EGF scaffolds on days 10, 15 and 20 post-surgery. Hematoxylin–Eosin (HE) staining confirmed these results by showing that on days 10, 15 and 20 post-surgery, the thicker epidermis and dermis layers were observed in the wounds covered with scaffolds containing HA and EGF than scaffolds alone. In addition, the thicker epidermis and dermis layers were also observed in the wounds covered with scaffolds containing EGF than scaffolds alone. Skin appendages were observed on day 20 only in the wound covered with scaffolds containing HA and EGF. These results demonstrate that the scaffolds containing HA and EGF can enhance wound healing. - Highlights: • HA can increase the adsorption of EGF to decellularized scaffolds. • HA can sustain the release of EGF from

  13. Comparative limb bone loading in the humerus and femur of the tiger salamander: testing the 'mixed-chain' hypothesis for skeletal safety factors.

    Science.gov (United States)

    Kawano, Sandy M; Economy, D Ross; Kennedy, Marian S; Dean, Delphine; Blob, Richard W

    2016-02-01

    Locomotion imposes some of the highest loads upon the skeleton, and diverse bone designs have evolved to withstand these demands. Excessive loads can fatally injure organisms; however, bones have a margin of extra protection, called a 'safety factor' (SF), to accommodate loads that are higher than normal. The extent to which SFs might vary amongst an animal's limb bones is unclear. If the limbs are likened to a chain composed of bones as 'links', then similar SFs might be expected for all limb bones because failure of the system would be determined by the weakest link, and extra protection in other links could waste energetic resources. However, Alexander proposed that a 'mixed-chain' of SFs might be found amongst bones if: (1) their energetic costs differ, (2) some elements face variable demands, or (3) SFs are generally high. To test whether such conditions contribute to diversity in limb bone SFs, we compared the biomechanical properties and locomotor loading of the humerus and femur in the tiger salamander (Ambystoma tigrinum). Despite high SFs in salamanders and similar sizes of the humerus and femur that would suggest similar energetic costs, the humerus had lower bone stresses, higher mechanical hardness and larger SFs. SFs were greatest in the anatomical regions where yield stresses were highest in the humerus and lowest in the femur. Such intraspecific variation between and within bones may relate to their different biomechanical functions, providing insight into the emergence of novel locomotor capabilities during the invasion of land by tetrapods. © 2016. Published by The Company of Biologists Ltd.

  14. Higher Education Marketing Strategies Based on Factors Impacting the Enrollees' Choice of a University and an Academic Program

    Science.gov (United States)

    Kalimullin, Aydar M.; Dobrotvorskaya, Svetlana G.

    2016-01-01

    The relevance of studying the stated problem is due to the fact that for increasing the efficiency of higher education marketing it is necessary to take into account several factors, namely, factors that impact the choice of a university and an academic program by enrollees, as well as socio-psychological characteristics of the latter, while…

  15. Load forecasting

    International Nuclear Information System (INIS)

    Mak, H.

    1995-01-01

    Slides used in a presentation at The Power of Change Conference in Vancouver, BC in April 1995 about the changing needs for load forecasting were presented. Technological innovations and population increase were said to be the prime driving forces behind the changing needs in load forecasting. Structural changes, market place changes, electricity supply planning changes, and changes in planning objectives were other factors discussed. It was concluded that load forecasting was a form of information gathering, that provided important market intelligence

  16. Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon

    DEFF Research Database (Denmark)

    Olesen, Jens L; Heinemeier, Katja M; Haddad, Fadia

    2006-01-01

    Insulin-like growth factor I (IGF-I) is known to exert an anabolic effect on tendon fibroblast production of collagen. IGF-I's regulation is complex and involves six different IGF binding proteins (IGFBPs). Of these, IGFBP-4 and -5 could potentially influence the effect of IGF-I in the tendon...... because they both are produced in fibroblast; however, the response of IGFBP-4 and -5 to mechanical loading and their role in IGF-I regulation in tendinous tissue are unknown. A splice variant of IGF-I, mechano-growth factor (MGF) is upregulated and known to be important for adaptation in loaded muscle....... However, it is not known whether MGF is expressed and upregulated in mechanically loaded tendon. This study examined the effect of mechanical load on tendon collagen mRNA in relation to changes in the IGF-I systems mRNA expression. Data were collected at 2, 4, 8 and 16 days after surgical removal...

  17. Transitioning in Higher Education: An Exploration of Psychological and Contextual Factors Affecting Student Satisfaction

    Science.gov (United States)

    Pennington, Charlotte R.; Bates, Elizabeth A.; Kaye, Linda K.; Bolam, Lauren T.

    2018-01-01

    In view of recent changes in the higher education sector, such as increased tuition fees, a greater focus has been placed on widening participation initiatives and monitoring student satisfaction. The aims of the current study were twofold: (1) to explore whether pre-entry programmes foster successful transition to higher education, and (2) to…

  18. Management and Accounting in English Higher Education Influenced by Environmental and Academia-Specific Factors

    Science.gov (United States)

    von Alberti-Alhtaybat, Larissa; Al-Htaybat, Khaldoon; Hutaibat, Khaled

    2012-01-01

    This article originates from a longitudinal study of management and accounting practices in the English higher education sector. The processes of strategic management and strategic management accounting in several English higher education institutions were investigated, from planning to assessment, and their meaning to members of staff. The study…

  19. Factors Favouring or Impeding Building a Stronger Higher Education System in the United Arab Emirates

    Science.gov (United States)

    Ashour, Sanaa; Fatima, Syeda Kauser

    2016-01-01

    The paper examines the inherent strengths and weaknesses of the higher education system in the United Arab Emirates (UAE). Using a literature review, three elements were examined: its development and structure, quality, and research capacity. The findings reveal that the UAE's higher education sector has witnessed remarkable growth since 1997,…

  20. Internet Plagiarism in Higher Education: Tendencies, Triggering Factors and Reasons among Teacher Candidates

    Science.gov (United States)

    Eret, Esra; Ok, Ahmet

    2014-01-01

    While plagiarism has been a growing problem in higher education for a long time, the use of the Internet has made this increasing problem more unmanageable. In many countries, this problem has become a matter of discussion, and higher education institutions feel obliged to review their policies on academic dishonesty. As part of these efforts, the…

  1. Understanding Taiwanese Students' Decision-Making Factors regarding Australian International Higher Education

    Science.gov (United States)

    Chen, Ching-Huei; Zimitat, Craig

    2006-01-01

    Purpose: The purpose of this paper is to investigate the motivators for Taiwanese students to study higher education in a western society. The behavioural motivations of Taiwanese students intending to undertake higher education in Australia and the USA were analysed using the theory of planned behaviour (TPB). Design/methodology/approach:…

  2. Instructional Benefits of Spoken Words: A Review of Cognitive Load Factors

    Science.gov (United States)

    Kalyuga, Slava

    2012-01-01

    Spoken words have always been an important component of traditional instruction. With the development of modern educational technology tools, spoken text more often replaces or supplements written or on-screen textual representations. However, there could be a cognitive load cost involved in this trend, as spoken words can have both benefits and…

  3. Investigation of the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV): exploratory and higher order factor analyses.

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W

    2010-12-01

    The present study examined the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical and Interpretation Manual (D. Wechsler, 2008b). Results indicated that the WAIS-IV subtests were properly associated with the theoretically proposed first-order factors, but all but one factor-extraction criterion recommended extraction of one or two factors. Hierarchical exploratory analyses with the Schmid and Leiman procedure found that the second-order g factor accounted for large portions of total and common variance, whereas the four first-order factors accounted for small portions of total and common variance. It was concluded that the WAIS-IV provides strong measurement of general intelligence, and clinical interpretation should be primarily at that level.

  4. Factors affecting stream nutrient loads: A synthesis of regional SPARROW model results for the continental United States

    Science.gov (United States)

    Preston, Stephen D.; Alexander, Richard B.; Schwarz, Gregory E.; Crawford, Charles G.

    2011-01-01

    We compared the results of 12 recently calibrated regional SPARROW (SPAtially Referenced Regressions On Watershed attributes) models covering most of the continental United States to evaluate the consistency and regional differences in factors affecting stream nutrient loads. The models - 6 for total nitrogen and 6 for total phosphorus - all provide similar levels of prediction accuracy, but those for major river basins in the eastern half of the country were somewhat more accurate. The models simulate long-term mean annual stream nutrient loads as a function of a wide range of known sources and climatic (precipitation, temperature), landscape (e.g., soils, geology), and aquatic factors affecting nutrient fate and transport. The results confirm the dominant effects of urban and agricultural sources on stream nutrient loads nationally and regionally, but reveal considerable spatial variability in the specific types of sources that control water quality. These include regional differences in the relative importance of different types of urban (municipal and industrial point vs. diffuse urban runoff) and agriculture (crop cultivation vs. animal waste) sources, as well as the effects of atmospheric deposition, mining, and background (e.g., soil phosphorus) sources on stream nutrients. Overall, we found that the SPARROW model results provide a consistent set of information for identifying the major sources and environmental factors affecting nutrient fate and transport in United States watersheds at regional and subregional scales. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

  5. Modeling and Finite Element Analysis of Load-Carrying Performance of a Wind Turbine Considering the Influence of Assembly Factors

    Directory of Open Access Journals (Sweden)

    Jianmei Wang

    2017-03-01

    Full Text Available In this work, a wind turbine shrink disk is used as the research object to investigate load-carrying performance of a multi-layer interference fit, and the theoretical model and finite element model are constructed. According to those models, a MW-level turbine shrink disk is designed, and a test device is developed to apply torque to this turbine shrink disk by hydraulic jack. Then, the circumferential slip between the contact surfaces is monitored and the slip of all contact surfaces is zero. This conclusion verifies the reasonability of the proposed models. The effect of the key influencing factors, such as machining deviation, assembly clearance and propel stroke, were analyzed. The contact pressure and load torque of the mating surfaces were obtained by building typical models with different parameters using finite element analysis (FEA. The results show that the minimum assembly clearance and the machining deviation within the machining range have little influence on load-carrying performance of multi-layer interference fit, while having a greater influence on the maximum assembly clearance and the propel stroke. The results also show that the load-carrying performance of a multiple-layer interference fit can be ensured only if the key factors are set within a reasonable design range. To avoid the abnormal operation of equipment caused by insufficient load torque, the propel stroke during practical assembly should be at least 0.95 times the designed propel stroke, which is significant in guiding the design and assembly of the multi-layer interference fit.

  6. The stress and stress intensity factors computation by BEM and FEM combination for nozzle junction under pressure and thermal loads

    International Nuclear Information System (INIS)

    Du, Q.; Cen, Z.; Zhu, H.

    1989-01-01

    This paper reports linear elastic fracture analysis based upon the stress intensity factor evaluation successfully applied to safety assessments of cracked structures. The nozzle junction are usually subjected to high pressure and thermal loads simultaneously. In validity of linear elastic fracture analysis, K can be decomposed into K P (caused by mechanic loads) and K τ (caused by thermal loads). Under thermal transient loading, explicit analysis (say by the FEM or BEM) of K tracing an entire history respectively for a range of crack depth may be much more time consuming. The techniques of weight function provide efficient means for transforming the problem into the stress computation of the uncracked structure and generation of influence function (for the given structure and size of crack). In this paper, a combination of BE-FEM has been used for the analysis of the cracked nozzle structure by techniques of weight function. The influence functions are obtained by coupled BE-FEM and the uncracked structure stress are computed by finite element methods

  7. Determination of Actual Friction Factors in Metal Forming under Heavy Loaded Regimes Combining Experimental and Numerical Analysis

    Science.gov (United States)

    Camacho, Ana María; Veganzones, Mariano; Claver, Juan; Martín, Francisco; Sevilla, Lorenzo; Sebastián, Miguel Ángel

    2016-01-01

    Tribological conditions can change drastically during heavy loaded regimes as experienced in metal forming; this is especially critical when lubrication can only be applied at the early stage of the process because the homogeneous lubricant layer can break along the die-workpiece interface. In these cases, adopting a constant friction factor for the lubricant-surface pair may not be a valid assumption. This paper presents a procedure based on the use of dual friction factor maps to determine friction factors employed in heavy loaded regimes. A finite element (FE) simulation is used to obtain the friction factor map for the alloy UNS A96082. Experiments were conducted using four lubricants (aluminum anti-size, MoS2 grease, silicone oil, and copper paste) to determine the actual friction curves. The experimental procedure is based on the application of lubricant only at the beginning of the first stage of ring compression, and not at intermediate stages as is usual in typical ring compression tests (RCTs). The results show that for small reductions (rh 20%), it is recommended to obtain an average value of the friction factor for every lubricant-surface pair in the range of deformation considered. PMID:28773868

  8. Determination of Actual Friction Factors in Metal Forming under Heavy Loaded Regimes Combining Experimental and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Ana María Camacho

    2016-09-01

    Full Text Available Tribological conditions can change drastically during heavy loaded regimes as experienced in metal forming; this is especially critical when lubrication can only be applied at the early stage of the process because the homogeneous lubricant layer can break along the die-workpiece interface. In these cases, adopting a constant friction factor for the lubricant-surface pair may not be a valid assumption. This paper presents a procedure based on the use of dual friction factor maps to determine friction factors employed in heavy loaded regimes. A finite element (FE simulation is used to obtain the friction factor map for the alloy UNS A96082. Experiments were conducted using four lubricants (aluminum anti-size, MoS2 grease, silicone oil, and copper paste to determine the actual friction curves. The experimental procedure is based on the application of lubricant only at the beginning of the first stage of ring compression, and not at intermediate stages as is usual in typical ring compression tests (RCTs. The results show that for small reductions (rh < 20%, the conventional RCT can be applied because the tribological conditions remain similar. For large reductions (rh > 20%, it is recommended to obtain an average value of the friction factor for every lubricant-surface pair in the range of deformation considered.

  9. Performance study of K{sub e} factors in simplified elastic plastic fatigue analyses with emphasis on thermal cyclic loading

    Energy Technology Data Exchange (ETDEWEB)

    Lang, Hermann, E-mail: hermann.lang@areva.com [AREVA NP GmbH, PEEA-G, Henri-Dunant-Strasse 50, 91058 Erlangen (Germany); Rudolph, Juergen; Ziegler, Rainer [AREVA NP GmbH, PEEA-G, Henri-Dunant-Strasse 50, 91058 Erlangen (Germany)

    2011-08-15

    As code-based fully elastic plastic code conforming fatigue analyses are still time consuming, simplified elastic plastic analysis is often applied. This procedure is known to be overly conservative for some conditions due to the applied plastification (penalty) factor K{sub e}. As a consequence, less conservative fully elastic plastic fatigue analyses based on non-linear finite element analyses (FEA) or simplified elastic plastic analysis based on more realistic K{sub e} factors have to be used for fatigue design. The demand for more realistic K{sub e} factors is covered as a requirement of practical fatigue analysis. Different code-based K{sub e} procedures are reviewed in this paper with special regard to performance under thermal cyclic loading conditions. Other approximation formulae such as those by Neuber, Seeger/Beste or Kuehnapfel are not evaluated in this context because of their applicability to mechanical loading excluding thermal cyclic loading conditions typical for power plant operation. Besides the current code-based K{sub e} corrections, the ASME Code Case N-779 (e.g. Adam's proposal) and its modification in ASME Section VIII is considered. Comparison of elastic plastic results and results from the Rules for Nuclear Facility Components and Rules for Pressure Vessels reveals a considerable overestimation of usage factor in the case of ASME III and KTA 3201.2 for the examined examples. Usage factors according to RCC-M, Adams (ASME Code Case N-779), ASME VIII (alternative) and EN 13445-3 are essentially comparable and less conservative for these examples. The K{sub v} correction as well as the applied yield criterion (Tresca or von Mises) essentially influence the quality of the more advanced plasticity corrections (e.g. ASME Code Case N-779 and RCC-M). Hence, new proposals are based on a refined K{sub v} correction.

  10. Performance study of Ke factors in simplified elastic plastic fatigue analyses with emphasis on thermal cyclic loading

    International Nuclear Information System (INIS)

    Lang, Hermann; Rudolph, Juergen; Ziegler, Rainer

    2011-01-01

    As code-based fully elastic plastic code conforming fatigue analyses are still time consuming, simplified elastic plastic analysis is often applied. This procedure is known to be overly conservative for some conditions due to the applied plastification (penalty) factor K e . As a consequence, less conservative fully elastic plastic fatigue analyses based on non-linear finite element analyses (FEA) or simplified elastic plastic analysis based on more realistic K e factors have to be used for fatigue design. The demand for more realistic K e factors is covered as a requirement of practical fatigue analysis. Different code-based K e procedures are reviewed in this paper with special regard to performance under thermal cyclic loading conditions. Other approximation formulae such as those by Neuber, Seeger/Beste or Kuehnapfel are not evaluated in this context because of their applicability to mechanical loading excluding thermal cyclic loading conditions typical for power plant operation. Besides the current code-based K e corrections, the ASME Code Case N-779 (e.g. Adam's proposal) and its modification in ASME Section VIII is considered. Comparison of elastic plastic results and results from the Rules for Nuclear Facility Components and Rules for Pressure Vessels reveals a considerable overestimation of usage factor in the case of ASME III and KTA 3201.2 for the examined examples. Usage factors according to RCC-M, Adams (ASME Code Case N-779), ASME VIII (alternative) and EN 13445-3 are essentially comparable and less conservative for these examples. The K v correction as well as the applied yield criterion (Tresca or von Mises) essentially influence the quality of the more advanced plasticity corrections (e.g. ASME Code Case N-779 and RCC-M). Hence, new proposals are based on a refined K v correction.

  11. Effect of Loads and Other Key Factors on Oil-Transformer Ageing: Sustainability Benefits and Challenges

    OpenAIRE

    Radu Godina; Eduardo M. G. Rodrigues; João C. O. Matias; João P. S. Catalão

    2015-01-01

    Transformers are one of the more expensive pieces of equipment found in a distribution network. The transformer’s role has not changed over the last decades. With simple construction and at the same time mechanically robust, they offer long term service that on average can reach half a century. Today, with the ongoing trend to supply a growing number of non-linear loads along with the notion of distributed generation (DG), a new challenge has arisen in terms of transformer sustainability, ...

  12. Stress Intensity Factors for Cracked Metallic Structures Under Rapid Thermal Loading

    Science.gov (United States)

    1987-10-01

    solution algorithm was developed based on the influence function method, and numerical results were generated to show the variation of K with flaw size and...numerical algorithms developed can be executed on a desktop microcomputer illustrating the efficient and powerful characteristic of the influence function method... Function Method 3-6 Superposition and Crack Face Loading Equivalence 3-7 Influence Function Generation 3-10 Influence Functions For Two Cracked Body

  13. Pre-aeration of food waste to augment acidogenic process at higher organic load: Valorizing biohydrogen, volatile fatty acids and biohythane.

    Science.gov (United States)

    Sarkar, Omprakash; Venkata Mohan, S

    2017-10-01

    Application of pre-aeration (AS) to waste prior to feeding was evaluated on acidogenic process in a semi-pilot scale biosystem for the production of biobased products (biohydrogen, volatile fatty acids (VFA) and biohythane) from food waste. Oxygen assisted in pre-hydrolysis of waste along with the suppression of methanogenic activity resulting in enhanced acidogenic product formation. AS operation resulted in 97% improvement in hydrogen conversion efficiency (HCE) and 10% more VFA production than the control. Increasing the organic load (OL) of food waste in association with AS application improved the productivity. The application of AS also influenced concentration and composition of fatty acid. Highest fraction of acetic (5.3g/l), butyric (0.7g/l) and propionic acid (0.84g/l) was achieved at higher OL (100g COD/l) with good degree of acidification (DOA). AS strategy showed positive influence on biofuel (biohydrogen and biohythane) production along with the biosynthesis of short chain fatty acids functioning as a low-cost pretreatment strategy in a single stage bioprocess. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Factors controlling stream water nitrate and phosphor loads during precipitation events

    Science.gov (United States)

    Rozemeijer, J.; van der Velde, Y.; van Geer, F.; de Rooij, G. H.; Broers, H.; Bierkens, M. F.

    2009-12-01

    Pollution of surface waters in densely populated areas with intensive land use is a serious threat to their ecological, industrial and recreational utilization. European and national manure policies and several regional and local pilot projects aim at reducing pollution loads to surface waters. For the evaluation of measures, water authorities and environmental research institutes are putting a lot of effort into monitoring surface water quality. Within regional surface water quality monitoring networks, the measurement locations are usually situated in the downstream part of the catchment to represent a larger area. The monitoring frequency is usually low (e.g. monthly), due to the high costs for sampling and analysis. As a consequence, human induced trends in nutrient loads and concentrations in these monitoring data are often concealed by the large variability of surface water quality caused by meteorological variations. Because this natural variability in surface water quality is poorly understood, large uncertainties occur in the estimates of (trends in) nutrient loads or average concentrations. This study aims at uncertainty reduction in the estimates of mean concentrations and loads of N and P from regional monitoring data. For this purpose, we related continuous records of stream water N and P concentrations to easier and cheaper to collect quantitative data on precipitation, discharge, groundwater level and tube drain discharge. A specially designed multi scale experimental setup was installed in an agricultural lowland catchment in The Netherlands. At the catchment outlet, continuous measurements of water quality and discharge were performed from July 2007-January 2009. At an experimental field within the catchment we collected continuous measurements of precipitation, groundwater levels and tube drain discharges. 20 significant rainfall events with a variety of antecedent conditions, durations and intensities were selected for analysis. Singular and

  15. Geometrical Sparing Factors for the Rectum and Bladder in the Prediction of Grade 2 and Higher Complications After High-Dose-Rate Brachytherapy for Cervical Cancer

    International Nuclear Information System (INIS)

    Chen, S.-W.; Liang, J.-A.; Hung, Y.-C.; Yeh, L.-S.; Chang, W.-C.; Yang, S.-N.; Lin, F.-J.

    2009-01-01

    Purpose: This study aimed to assess the predictive values of geometrical sparing factors for the rectum and bladder in high-dose-rate intracavitary brachytherapy (HDRICB) for Grade 2 and higher late sequelae in patients with cervical cancer. Methods: A total of 392 patients were enrolled in this study. They were treated with external beam radiotherapy to the pelvis, after which HDRICB was performed using Ir-192 remote after-loading at 1-week intervals for three or four sessions. The geometrical sparing factor (GSF) was defined as the average of the ratios between the reference doses and the Point A dose. Results: A total of 46 patients (11.7%) had Grade 2 or higher late rectal complications (36 Grade 2, 9 Grade 3, and 1 Grade 4). In all, 32 patients (8.2%) had Grade 2 or higher late bladder complications (14 Grade 2, 16 Grade 3, and 2 Grade 4). Multivariate analysis demonstrated a high risk of rectal sequelae in patients who developed bladder complications (p = 0.0004, hazard ratio 3.54) and had a rectal GSF greater than 0.7 (p = 0.01, hazard ratio 1.99). The high risk factors for bladder complications were development of rectal complications (p = 0.0004, hazard ratio 3.74), concurrent chemotherapy (p = 0.0001, relative risk 3.94), and a bladder GSF greater than 0.9 (p = 0.01, hazard ratio, 2.53). Conclusion: This study demonstrates the predictive value of GSFs in HDRICB for cervical cancer. Patients with rectal GSFs greater than 0.7 or bladder GSFs greater than 0.9 are at risk for Grade 2 and higher late sequelae.

  16. Geometrical sparing factors for the rectum and bladder in the prediction of grade 2 and higher complications after high-dose-rate brachytherapy for cervical cancer.

    Science.gov (United States)

    Chen, Shang-Wen; Liang, Ji-An; Hung, Yao-Ching; Yeh, Lian-Shung; Chang, Wei-Chun; Yang, Shih-Neng; Lin, Fang-Jen

    2009-12-01

    This study aimed to assess the predictive values of geometrical sparing factors for the rectum and bladder in high-dose-rate intracavitary brachytherapy (HDRICB) for Grade 2 and higher late sequelae in patients with cervical cancer. A total of 392 patients were enrolled in this study. They were treated with external beam radiotherapy to the pelvis, after which HDRICB was performed using Ir-192 remote after-loading at 1-week intervals for three or four sessions. The geometrical sparing factor (GSF) was defined as the average of the ratios between the reference doses and the Point A dose. A total of 46 patients (11.7%) had Grade 2 or higher late rectal complications (36 Grade 2, 9 Grade 3, and 1 Grade 4). In all, 32 patients (8.2%) had Grade 2 or higher late bladder complications (14 Grade 2, 16 Grade 3, and 2 Grade 4). Multivariate analysis demonstrated a high risk of rectal sequelae in patients who developed bladder complications (p = 0.0004, hazard ratio 3.54) and had a rectal GSF greater than 0.7 (p = 0.01, hazard ratio 1.99). The high risk factors for bladder complications were development of rectal complications (p = 0.0004, hazard ratio 3.74), concurrent chemotherapy (p = 0.0001, relative risk 3.94), and a bladder GSF greater than 0.9 (p = 0.01, hazard ratio, 2.53). This study demonstrates the predictive value of GSFs in HDRICB for cervical cancer. Patients with rectal GSFs greater than 0.7 or bladder GSFs greater than 0.9 are at risk for Grade 2 and higher late sequelae.

  17. The more publication, the higher impact factor: citation analysis of top nine gastroenterology and hepatology journals.

    Science.gov (United States)

    Karimi Elizee, Pegah; Karimzadeh Ghassab, Romina; Raoofi, Azam; Miri, Seyyed Mohammad

    2012-12-01

    The impact factor (IF), as the most important criterion for journal's quality measurement, is affected by the self-citation and number of publications in each journal. To find out the relationship between the number of publications and self-citations in a journal, and their correlations with IF. Self-citations and impact factors of nine top gastroenterology and hepatology journals were assessed during the seven recent years (2005-2011) through Journal Citation Reports (JCR, ISI Thomson Reuters). Although impact factors of all journals increased during the study, five out of nine journals increased the number of publications from 2005 to 2011. There was an increase in self-citation only in the journal of HEPATOLOGY (499 in 2005 vs. 707 in 2011). Impact factors of journals (6.5 ± 3.5) were positively correlated with total number of publications (248.6 ± 91.7) (R: 0.688, P citation rate (238.73 ± 195.317) was highly correlated with total number of publications in each journal (248.6 ± 91.7) (R: 0.861, P citation (6.08 ± 3.3) had a correlation (R: 0.672, P citation have definite effects on IF of a journal and because IF is the most prominent criterion for journal's quality measurement, it would be a good idea to consider factors affecting on IF such as self-citation.

  18. Factors Associated With Higher Caregiver Burden Among Family Caregivers of Elderly Cancer Patients: A Systematic Review.

    Science.gov (United States)

    Ge, Lixia; Mordiffi, Siti Zubaidah

    Caring for elderly cancer patients may cause multidimensional burden on family caregivers. Recognition of factors associated with caregiver burden is important for providing proactive support to caregivers at risk. The aim of this study was to identify factors associated with high caregiver burden among family caregivers of elderly cancer patients. A systematic search of 7 electronic databases was conducted from database inception to October 2014. The identified studies were screened, and full text was further assessed. The quality of included studies was assessed using a checklist, and relevant data were extracted using a predeveloped data extraction form. Best-evidence synthesis model was used for data synthesis. The search yielded a total of 3339 studies, and 7 studies involving 1233 family caregivers were included after screening and full assessment of 116 studies. Moderate evidence supported that younger caregivers, solid tumors, and assistance with patient's activities of daily living were significantly associated with high caregiver burden. Eighteen factors were supported by limited evidence, and 1 was a conflicting factor. The scientific literature to date proved that caregiver burden was commonly experienced by family caregivers of elderly cancer patients. The evidence indicated that family caregivers who were at younger age, caring for solid tumor patients, and providing assistance with patient's activities of daily living reported high caregiver burden. The data provide evidence in identifying family caregivers at high risk of high caregiver burden. More high-quality studies are needed to clarify and determine the estimates of the effects of individual factors.

  19. Determining e-learning success factor in higher education based on user perspective using Fuzzy AHP

    Directory of Open Access Journals (Sweden)

    Anggrainingsih Rini

    2018-01-01

    Full Text Available Recently almost all universities in the world have implemented E-learning to support their academic system. Previous studies have been conducted to determine CSF using Analytic Hierarchy Process (AHP method. However, AHP method cannot handle the uncertainty and vagueness of the human’s opinion, so then it causes less appropriate decision. Some researcher has proposed to use fuzzy sets theory with AHP to increase the ability of AHP to deal problem regarding the uncertainty/fuzziness. This study aims to determine ranks of priorities of the multiple factors which influence the E-learning success using FAHP method. The respondents consist of ten e-learning’s experts, 305 lecturers, and 4195 students at Sebelas Maret University. The result describes similar success factors ranking between both experienced and non-experienced user (lecturer and student. Then, the result shows that there are five most influencial success factors of e-learning at Sebelas Maret University based on the lectures perspective Financial Policy, Regulatory Policy, Course quality, Relevant Content and Technical Support. On the other hand, according to the student's point of view five most e-learning, critical success factors are Quality of Course, Relevant of Content, Completeness of Content, Attitudes toward Student, and Flexibility in taking Course. Therefore, this finding can be used by E-learning management of Sebelas Maret University to deteremine a strategy to to achieve successful implementation of e-learning at Sebelas Maret University with consider these factors.

  20. The Role of Socioeconomic Factor in Promoting Higher Education in the State of Kuwait

    Science.gov (United States)

    Al Darwish, Salwa

    2016-01-01

    The purpose of this research study is to determine the level of influence of parental education, social and financial status on their senior college students by encouraging them to pursue higher degrees. The sample of the study was 313 senior college students randomly selected from private and public universities in Kuwait to answer the…

  1. Instructor Support Services: An Inevitable Critical Success Factor in Blended Learning in Higher Education in Tanzania

    Science.gov (United States)

    Raphael, Christina; Mtebe, Joel S.

    2016-01-01

    The adoption of blended learning to widen access, reduce cost, and improve the quality of education is becoming prevalent in higher education in sub-Saharan Africa and Tanzania in particular. University of Dar es Salaam and the Open University of Tanzania offer various blended learning courses using Moodle system via regional centres scattered…

  2. Factors Affecting Teachers' Motivation: An HRM Challenge for Public Sector Higher Educational Institutions of Pakistan (HEIs)

    Science.gov (United States)

    Rasheed, Muhammad Imran; Humayon, Asad Afzal; Awan, Usama; Ahmed, Affan ud Din

    2016-01-01

    Purpose: The purpose of this paper is to explore/investigate various issues of teachers ' motivation in public sector Higher Educational Institutions of Pakistan. Design/methodology/approach: This is an exploratory research where surveys have been conducted in the well known public sector Universities of Pakistan; primary data have been collected…

  3. Attitudes of Higher Education Students to New Venture Creation: The Relevance of Competencies and Contextual Factors

    Science.gov (United States)

    Teixeira, Aurora A. C.; Davey, Todd

    2010-01-01

    Higher education institutions (HEIs) play an important role in the generation of high-tech "entrepreneurial capacity". As entrepreneurship education gives greater attention to the creation of new ventures, there is an urgent need for a better understanding of the attitudes of students, potentially the entrepreneurs of the future. Logit…

  4. Factors Affecting University Image Formation among Prospective Higher Education Students: The Case of International Branch Campuses

    Science.gov (United States)

    Wilkins, Stephen; Huisman, Jeroen

    2015-01-01

    Previous research has found that the images of universities formed by prospective students greatly influence their choices. With the advent of international branch campuses in several higher education hubs worldwide, many international students now attempt to construct images of these institutions when deciding where to study. The aim of this…

  5. Post-Implementation Success Factors for Enterprise Resource Planning Student Administration Systems in Higher Education Institutions

    Science.gov (United States)

    Sullivan, Linda; Bozeman, William

    2010-01-01

    Enterprise Resource Planning (ERP) systems can represent one of the largest investments of human and financial resources by a higher education institution. They also bring a significant process reengineering aspect to the institution and the associated implementation project through the integration of compiled industry best practices into the…

  6. Choices of Destination for Transnational Higher Education: "Pull" Factors in an Asia Pacific Market

    Science.gov (United States)

    Ahmad, Syed Zamberi; Buchanan, Frederick Robert

    2016-01-01

    Traditional assumptions favouring native English language countries in transnational higher education (TNHE) overlook experiences of international students in new emerging Asian education hubs. Specifically, there has been limited research relating to international students' choice for studying in Malaysia. Drawing from the "push-pull"…

  7. Students' educational careers in higher education : a search into key factors regarding study outcome

    NARCIS (Netherlands)

    Bragt, van C.A.C.

    2010-01-01

    One of the political goals of the EU is to develop ‘the most competitive knowledge-based economy in the world by 2010’. The Dutch knowledge economy faces an increased demand for highly-educated inhabitants, and more graduates from Higher Education are needed. Dutch Universities of Applied Sciences

  8. An Examination of Motivating Factors on Faculty Participation in Online Higher Education

    Science.gov (United States)

    Hoffman, Michael S.

    2013-01-01

    Online education has become a vital component of the American higher education system. Demand for online education is expected to grow, as online education offers a number of tangible benefits to potential students. Faculty member participation in online education has been found to be crucial to the success of new or expanded online education…

  9. National Culture and Higher Education as Pre-Determining Factors of Student Entrepreneurship

    Science.gov (United States)

    Roman, Teodora; Maxim, Alexandru

    2017-01-01

    Our purpose is to assess the influence of national culture and higher education on entrepreneurship among students and fresh graduates. The aim was to determine whether the grouping of students based on certain personality traits (most of which are connected to culture) is effective at predicting entrepreneurial intention and whether…

  10. Exploring Factors That Influence Adoption of e-Learning within Higher Education

    Science.gov (United States)

    King, Emma; Boyatt, Russell

    2015-01-01

    E-learning is increasingly adopted in the workplace for supporting professional development and continuing education; however, in higher education, the use of e-learning is predominantly used as a tool support teaching. As a relatively new priority for universities, this paper explores what influences its adoption. Challenges identified in the…

  11. Flexibility factors for small (d/D<1/3) branch connections with external loadings

    International Nuclear Information System (INIS)

    Rodabaugh, E.C.; Moore, S.E.

    1977-03-01

    A piping system analysis is accurate only to the extent that the flexibilities of all portions of the piping system are accurately known. The use of a ''conservative'' flexibility factor is not possible because such a factor cannot be defined. Branch connections require a definition of flexibility factor which is conceptually different than commonly used for curved pipe. An appropriate definition for the flexibility factors of branch connections is presented. The background of the present Code formulations of flexibility factors for branch connections is discussed. Additional theoretical data and test data are summarized. Recommendations are given for revisions to Code formulations for handling the flexibility of branch connections in a piping system analysis

  12. Higher-twist effects in the B → π transition form factor from QCD light-cone sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Khodjamirian, Alexander; Rusov, Aleksey [Universitaet Siegen (Germany). Fakultaet IV, Department Physik, Theoretische Physik 1 Walter-Flex-Strasse 3 57068 Siegen

    2016-07-01

    I report on the progress in calculating new higher-twist corrections to the QCD light-cone sum rule for the B → π transition form factor. First, the expansion of the massive heavy-quark propagator in the external gluonic field near the light-cone was extended to include new terms containing the gluon-field strength derivatives. The resulting analytical expressions for the twist-5 and twist-6 contributions to the correlation function were obtained in a factorized approximation, expressed via the product of the quark-condensate density and the lower-twist pion distribution amplitudes. The numerical analysis of new higher-twist effects is in progress.

  13. Low bone density risk is higher in exercising women with multiple triad risk factors.

    Science.gov (United States)

    Gibbs, Jenna C; Nattiv, Aurelia; Barrack, Michelle T; Williams, Nancy I; Rauh, Mitchell J; Nichols, Jeanne F; De Souza, Mary Jane

    2014-01-01

    The cumulative effect of the female athlete triad (Triad) risk factors on the likelihood of low bone mineral density (BMD) in exercising women is unclear. This study aimed to determine the risk of low BMD in exercising women with multiple Triad risk factors. We retrospectively examined cross-sectional data from 437 exercising women (mean ± SD age of 18.0 ± 3.5 yr, weighed 57.5 ± 7.1 kg with 24.5% ± 6.1% body fat) obtained at baseline from 4 prospective cohort studies examining Triad risk factors. Questionnaires were completed to obtain information on demographic characteristics, self-reported eating attitudes/behaviors, menstrual function, sport/activity participation, and medication use. Height and body weight were measured. BMD was measured using dual energy x-ray absorptiometry. Low BMD was defined as z-scores of exercising women. Further research should be conducted to develop a user-friendly algorithm integrating these indicators of risk for low BMD in exercising women (particularly factors associated with low BMI/body weight, menstrual dysfunction, lean sport/activity participation, and elevated dietary restraint).

  14. Determinants of Business Student Satisfaction and Retention in Higher Education: Applying Herzberg's Two-Factor Theory

    Science.gov (United States)

    DeShields, Oscar W., Jr.; Kara, Ali; Kaynak, Erdener

    2005-01-01

    Purpose: This paper focuses on the determinants of student satisfaction and retention in a college or university that are assumed to impact students' college experience. Design/methodology/approach: Using empirical data and Herzberg's two-factor theory, a modified version of the questionnaire developed by Keaveney and Young was administered to…

  15. Critical Factors Affecting Students' Satisfaction with Higher Education in Sri Lanka

    Science.gov (United States)

    Weerasinghe, I. M. S.; Fernando, R. L. S.

    2018-01-01

    Purpose: The purpose of this study is to explain critical factors affecting student satisfaction levels in selected state universities in Sri Lanka. Design/methodology/approach: The study has applied an quantitative survey design guided by six hypotheses. A conceptual framework has been developed to address the research questions on the basis of a…

  16. Reshaping Computer Literacy Teaching in Higher Education: Identification of Critical Success Factors

    Science.gov (United States)

    Taylor, Estelle; Goede, Roelien; Steyn, Tjaart

    2011-01-01

    Purpose: Acquiring computer skills is more important today than ever before, especially in a developing country. Teaching of computer skills, however, has to adapt to new technology. This paper aims to model factors influencing the success of the learning of computer literacy by means of an e-learning environment. The research question for this…

  17. Factors Influencing the Use of Learning Management System in Saudi Arabian Higher Education: A Theoretical Framework

    Science.gov (United States)

    Asiri, Mohammed J. Sherbib; Mahmud, Rosnaini bt; Bakar, Kamariah Abu; Ayub, Ahmad Fauzi bin Mohd

    2012-01-01

    The purpose of this paper is to present the theoretical framework underlying a research on factors that influence utilization of the Jusur Learning Management System (Jusur LMS) in Saudi Arabian public universities. Development of the theoretical framework was done based on library research approach. Initially, the existing literature relevant to…

  18. A Comparative Study of Factors Influencing Male and Female Lecturers' Job Satisfaction in Ghanaian Higher Education

    Science.gov (United States)

    Amos, Patricia Mawusi; Acquah, Sakina; Antwi, Theresa; Adzifome, Nixon Saba

    2015-01-01

    The study sought to compare factors influencing male and female lecturers' job satisfaction. Cross-sectional survey designs employing both quantitative and qualitative approaches were adopted for the study. Simple random sampling was used to select 163 lecturers from the four oldest public universities in Ghana. Celep's (2000) Organisational…

  19. Contemporary Constructivist Practices in Higher Education Settings and Academic Motivational Factors

    Science.gov (United States)

    Alt, Dorit

    2016-01-01

    This study was aimed at assessing the relationships between college students' pre-entry factors, self-efficacy and motivation for learning, and the perceived constructivist learning in traditional lecture-based courses and seminars (SM). The study included 411 undergraduate third-year college students. Several scales were administered to the…

  20. Refined shear correction factor for very thick simply supported and uniformly loaded isosceles right triangular auxetic plates

    International Nuclear Information System (INIS)

    Lim, Teik-Cheng

    2016-01-01

    For moderately thick plates, the use of First order Shear Deformation Theory (FSDT) with a constant shear correction factor of 5/6 is sufficient to take into account the plate deflection arising from transverse shear deformation. For very thick plates, the use of Third order Shear Deformation Theory (TSDT) is preferred as it allows the shear strain distribution to be varied through the plate thickness. Therefore no correction factor is required in TSDT, unlike FSDT. Due to the complexity involved in TSDT, this paper obtains a more accurate shear correction factor for use in FSDT of very thick simply supported and uniformly loaded isosceles right triangular plates based on the TSDT. By matching the maximum deflections for this plate according to FSDT and TSDT, a variable shear correction factor is obtained. Results show that the shear correction factor for the simplified TSDT, i.e. 14/17, is least accurate. The commonly adopted shear correction factor of 5/6 in FSDT is valid only for very thin or highly auxetic plates. This paper provides a variable shear correction for FSDT deflection that matches the plate deflection by TSDT. This variable shear correction factor allows designers to justify the use of a commonly adopted shear correction factor of 5/6 even for very thick plates as long as the Poisson’s ratio of the plate material is sufficiently negative. (paper)

  1. Family load estimates and risk factors of anxiety disorders in a nationwide three generation study

    DEFF Research Database (Denmark)

    Helenius, Dorte; Munk-Jørgensen, Povl; Steinhausen, Hans-Christoph

    2014-01-01

    region. Psychiatric diagnoses were also obtained for parents, siblings, and offspring. A family load component was obtained by using various mixed regression models. Anxiety disorders occurred significantly more often in case than in control families. Having a mother, father, or a sibling......The present study investigated how often anxiety disorders with different ages of onset occurred in affected families compared to control families. Furthermore, the study addressed the impact of sex, region of residence, year and month of birth, and parental age at birth. The sample included N=1373......, provide further and solid evidence for the family aggregation of anxiety disorders....

  2. COMPETITIVENESS AS A FACTOR FOR CHOICE OF UKRAINIAN YOUTHRECEIVE HIGHER EDUCATION ABROAD1

    OpenAIRE

    ZUBCHYK OLEG ANATOLIIOVYCH

    2017-01-01

    The author compared the country’s competitiveness performance and competitiveness of higher education in the Global Competitiveness Index of the World Economic Forum (Switzerland) and ranking of global competitiveness Management Institute (Switzerland). For comparison, selected countries whereResearch done withint here search theme of Kyiv National Taras Shevchenko University “16 BF 041-01. Modernization of philosophy and political science education and science of Ukraine on thebasis of inter...

  3. Neuropsychological factors related to returning to work in patients with higher brain dysfunction.

    Science.gov (United States)

    Kai, Akiko; Hashimoto, Manabu; Okazaki, Tetsuya; Hachisuka, Kenji

    2008-12-01

    We conducted neuropsychological tests of patients with higher brain dysfunction to examine the characteristics of barriers to employment. We tested 92 patients with higher brain dysfunction (average age of 36.3 +/- 13.8 years old, ranging between 16 and 63 years old, with an average post-injury period of 35.6 +/- 67.8 months) who were hospitalized at the university hospital between February 2002 and June 2007 for further neuropsychological evaluation, conducting the Wechsler Adult Intelligence Scale-Revised (WAIS-R), Wechsler Memory Scale-Revised (WMS-R), the Rivermead Behavioral Memory Test (RBMT), Frontal Assessment Battery (FAB) and Behavioral Assessment of Dysexecutive Syndrome (BADS). The outcomes after discharge were classified between competitive employment, sheltered employment and non-employment, and the three groups were compared using one-way analysis of variance and the Scheffe test. The WAIS-R subtests were mutually compared based on the standard values of significant differences described in the WAIS-R manual. Verbal performance and full scale Intelligence Quotient (IQ) of WAIS-R were 87.7 +/- 15.6 (mean +/- standard deviation), 78.5 +/- 18.1 and 81.0 +/- 17.2, respectively, and verbal memory, visual memory, general memory, attention/concentration and delayed recall were 74.6 +/- 20.0, 76.6 +/- 21.4, 72.0 +/- 20.4, 89.0 +/- 16.5 and 65.2 +/- 20.8, respectively. The competitive employment group showed significantly higher scores in performance IQ and full IQ on the WAIS-R and verbal memory, visual memory, general memory and delayed recall on the WMS-R and RBMT than the non-employment group. The sheltered employment group showed a significantly higher score in delayed recall than the non-employment group. No difference was observed in the FAB or BADS between the three groups. In the subtests of the WAIS-R, the score for Digit Symbol-Coding was significantly lower than almost all the other subtests. For patients with higher brain dysfunction, IQ (full

  4. Khat chewing among students of higher education in Jazan region, Saudi Arabia: prevalence, pattern, and related factors.

    Science.gov (United States)

    Alsanosy, Rashad Mohammed; Mahfouz, Mohamed Salih; Gaffar, Abdelrahim Mutwakel

    2013-01-01

    (1) To estimate the prevalence and behavioral patterns of Khat chewing and (2) to investigate factors that influenced the pattern of Khat use among undergraduate students in different higher education institutions in Jazan region, Saudi Arabia. A cross-sectional study using a pretested structured self-administered quantitative questionnaire was used to collect data. SPSS version 17 software program was used for data analysis. The overall current Khat chewing prevalence among higher education students was found to be 23.1%, significantly higher among males at 38.5% than among females at 2.1% (P higher compared with females at 3.7% (P higher education students in Jazan region. A multilevel, value based, comprehensive, and strategic long-term intervention plan is needed. The comprehensive plan may include social interventions geared by creating recreations alternatives and opportunities for youth and a critical review for current authorities' interventions and services.

  5. Stress-intensity factor equations for cracks in three-dimensional finite bodies subjected to tension and bending loads

    Science.gov (United States)

    Newman, J. C., Jr.; Raju, I. S.

    1984-01-01

    Stress intensity factor equations are presented for an embedded elliptical crack, a semielliptical surface crack, a quarter elliptical corner crack, a semielliptical surface crack along the bore of a circular hole, and a quarter elliptical corner crack at the edge of a circular hole in finite plates. The plates were subjected to either remote tension or bending loads. The stress intensity factors used to develop these equations were obtained from previous three dimensional finite element analyses of these crack configurations. The equations give stress intensity factors as a function of parametric angle, crack depth, crack length, plate thickness, and, where applicable, hole radius. The ratio of crack depth to plate thickness ranged from 0 to 1, the ratio of crack depth to crack length ranged from 0.2 to 2, and the ratio of hole radius to plate thickness ranged from 0.5 to 2. The effects of plate width on stress intensity variation along the crack front were also included.

  6. Confirmatory factor analysis of teaching and learning guiding principles instrument among teacher educators in higher education institutions

    Science.gov (United States)

    Masuwai, Azwani; Tajudin, Nor'ain Mohd; Saad, Noor Shah

    2017-05-01

    The purpose of this study is to develop and establish the validity and reliability of an instrument to generate teaching and learning guiding principles using Teaching and Learning Guiding Principles Instrument (TLGPI). Participants consisted of 171 Malaysian teacher educators. It is an essential instrument to reflect in generating the teaching and learning guiding principles in higher education level in Malaysia. Confirmatory Factor Analysis has validated all 19 items of TLGPI whereby all items indicated high reliability and internal consistency. A Confirmatory Factor Analysis also confirmed that a single factor model was used to generate teaching and learning guiding principles.

  7. Potential Explanatory Factors for Higher Incident Hip Fracture Risk in Older Diabetic Adults

    Directory of Open Access Journals (Sweden)

    Elsa S. Strotmeyer

    2011-01-01

    Full Text Available Type 2 diabetes is associated with higher fracture risk. Diabetes-related conditions may account for this risk. Cardiovascular Health Study participants (N=5641; 42.0% men; 15.5% black; 72.8±5.6 years were followed 10.9 ± 4.6 years. Diabetes was defined as hypoglycemic medication use or fasting glucose (FG ≥126 mg/dL. Peripheral artery disease (PAD was defined as ankle-arm index <0.9. Incident hip fractures were from medical records. Crude hip fracture rates (/1000 person-years were higher for diabetic vs. non-diabetic participants with BMI <25 (13.6, 95% CI: 8.9–20.2 versus 11.4, 95% CI: 10.1–12.9 and BMI ≥25 to <30 (8.3, 95% CI: 5.7–11.9 versus 6.6, 95% CI: 5.6–7.7, but similar for BMI ≥30. Adjusting for BMI, sex, race, and age, diabetes was related to fractures (HR = 1.34; 95% CI: 1.01–1.78. PAD (HR = 1.25 (95% CI: 0.92–1.57 and longer walk time (HR = 1.07 (95% CI: 1.04–1.10 modified the fracture risk in diabetes (HR = 1.17 (95% CI: 0.87–1.57. Diabetes was associated with higher hip fracture risk after adjusting for BMI though this association was modified by diabetes-related conditions.

  8. Higher serum levels of rheumatoid factor and anti-nuclear antibodies in helicobacter pylori-infected peptic ulcer patients.

    Science.gov (United States)

    Jafarzadeh, Abdollah; Nemati, Maryam; Rezayati, Mohammad Taghi; Nabizadeh, Mansooreh; Ebrahimi, Medhi

    2013-07-01

    H. pylori infection has been associated with some autoimmune disorders. The aim of this study was to evaluate the serum concentrations of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected peptic ulcer patients, H. pylori-infected asymptomatic carriers and a healthy control group. A Total of 100 H. pylori-infected peptic ulcer patients, 65 asymptomatic carriers and 30 healthy H. pylori-negative subjects (as a control group) were enrolled into study. Serum samples of participants tested for the levels of rheumatoid factor and anti-nuclear antibodies by use of ELISA. The mean serum levels of rheumatoid factor and anti-nuclear antibodies in peptic ulcer group was significantly higher in comparison to the control group (ppeptic ulcer patients and asymptomatic carriers groups regarding the mean serum levels of rheumatoid factor and anti-nuclear antibodies. The mean serum levels of rheumatoid factor in men with peptic ulcer was significantly higher compared to the group of healthy men (ppeptic ulcer patients or asymptomatic carriers groups, the mean serum levels of rheumatoid factor was higher than that in healthy women, but the differences were not statistically significant. Also, no significant differences were observed between men and women with peptic ulcer, asymptomatic carriers control groups based on the serum levels of anti-nuclear antibodies. The results showed higher serum levels of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected patients with peptic ulcer disease which represent the H. pylori-related immune disturbance in these patients. Additional follow-up studies are necessary to clarify the clinical significance of these autoantibodies in patients with H. pylori infection.

  9. Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

    International Nuclear Information System (INIS)

    Ribeiro, M.P.; Morgado, P.I.; Miguel, S.P.; Coutinho, P.; Correia, I.J.

    2013-01-01

    Skin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and histological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine. - Highlights: • Evaluation of a hydrogel loaded with microparticles containing growth factors for wound healing • In vitro and in vivo assays were performed to characterize the properties of the skin substitute. • The monitoring of the wound healing process was done by macroscopic and histological analysis

  10. Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, M.P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda (Portugal); Morgado, P.I.; Miguel, S.P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); Coutinho, P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda (Portugal); Correia, I.J., E-mail: icorreia@ubi.pt [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal)

    2013-07-01

    Skin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and histological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine. - Highlights: • Evaluation of a hydrogel loaded with microparticles containing growth factors for wound healing • In vitro and in vivo assays were performed to characterize the properties of the skin substitute. • The monitoring of the wound healing process was done by macroscopic and histological analysis.

  11. Toward Digital Citizenship: Examining Factors Affecting Participation and Involvement in the Internet Society among Higher Education Students

    Science.gov (United States)

    Al-Zahrani, Abdulrahman

    2015-01-01

    The current study aims to understand digital citizenship, based on the assumptions of Ribble (2014), by examining factors affecting participation and involvement in the Internet virtual societies among higher education students. A quantitative approach using a survey questionnaire was implemented. The participants were 174 students from the…

  12. Workforce Diversity in Higher Education: Career Support Factors Influencing Ascendancy of African American Women to Senior-Level Positions

    Science.gov (United States)

    Blackstone, Tondelaya K.

    2011-01-01

    The focus of this study was how knowledge of the barriers to advancement for African American women (AAW) and key career support factors (KCSFs) influence the career advancement of African American women (AAW) to senior-level positions in higher education. The research method for this study consisted of the triangulation of evidence from multiple…

  13. An Exploration of Support Factors Available to Higher Education Students with High Functioning Autism or Asperger Syndrome

    Science.gov (United States)

    Rutherford, Emily N.

    2013-01-01

    This qualitative phenomenological research study used narrative inquiry to explore the support factors available to students with High Functioning Autism or Asperger Syndrome in higher education that contribute to their success as perceived by the students. Creswell's (2009) six step method for analyzing phenomenological studies was used to…

  14. Dependence of twinned volume fraction on loading mode and Schmid factor in randomly textured magnesium

    Czech Academy of Sciences Publication Activity Database

    Čapek, Jan; Máthis, K.; Clausen, B.; Barnett, M.R.

    2017-01-01

    Roč. 130, MAY (2017), s. 319-328 ISSN 1359-6454 R&D Projects: GA ČR GB14-36566G Institutional support: RVO:61389005 Keywords : twinning * magnesium * neutron diffraction * Schmid factor Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 5.301, year: 2016

  15. Factors affecting students’ attitude towards introduction of tuition fees for higher education in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Martina Zámková

    2013-01-01

    Full Text Available Introduction of tuition fees has been much discussed in the Czech Republic over the recent years. Unfortunately, the current system of non-discriminate higher-education funding is no longer supportable, that is, provided that we do not want all universities to be evenly “mediocre”. A well configured tuition-fee system with low payments, suitably complemented by student loans covering not only the tuition fees but also the subsistence costs could be an acceptable vision of the future higher education. The obligation to pay for the study should also prevent from enrolment those applicants that only enter a university to avoid having to cater for themselves in real life. A survey was conducted to find out the views of Czech university students on the introduction of tuition fees and the possible methods of their payment. A subsequent analysis was made to see whether the introduction of tuition fees would aggravate students’ financial situation, whether they would be more motivated to complete the studies in due time, and whether they would be more concerned with the quality of teaching. The survey also analysed the relationship between a respondent’s view on the introduction of tuition fees and the current methods of financing the studies (accommodation, transport, meals, textbooks, …, the household income, and the gender. It also takes into account the attitude of respondents on the system of student loans proposed. In order to interpret the results correspondence and dependence analysis were used.

  16. TEACHERS' PERSPECTIVE ABOUT FACTORS THAT PREVENT SUCCESS IN TEACHING AND LEARNING PROCESS IN HIGHER EDUCATION OF ENGINEERING IN BRAZIL

    Directory of Open Access Journals (Sweden)

    Gláucia Nolasco de Almeida Mello

    2016-12-01

    Full Text Available The last fifteen years, in Brazil, the number of engineering freshmen had a huge increased and, although the number of graduated also had increased over the same period, the percentage of engineering freshmen are by far higher than engineers graduated. In this context, there is a clear evidence of the high dropout rate in higher education courses of engineering in Brazil. Once most of developed researches about engineering courses dropout in Brazil are focused in the students and institutions point of view about factors that affect dropout rate, in this research it was investigated the professors perspective to answer the three questions: (1 What are the main factors which prevent success in teaching and learning process identified by professors of engineering during the classes? (2 How can professors to improve the teaching and learning process in higher education courses of engineering in Brazil? (3 How can Higher Education Institutions (HEI support the professors? The research data were collected through team activities developed with 134 professors of higher education courses of engineering. This research reveals that the most important factors that affect negatively the teaching and learning process are related to inadequate high school preparation and behaviour of students. Main suggestions of professors for improving the teaching and learning process and also students' motivation are related to pedagogical aspects such as: use of Information and Communication Technologies (ICTs as support of classes and implementation of professor and student support programs with significant participation of HEI.

  17. Higher incidence of nasopharyngeal carcinoma in some regions in the world confers for interplay between genetic factors and external stimuli.

    Science.gov (United States)

    Roy Chattopadhyay, Nabanita; Das, Piyanki; Chatterjee, Koustav; Choudhuri, Tathagata

    2017-01-01

    Nasopharyngeal carcinoma (NPC) is a rare variety of head and neck cancers. The risk factors include three major causes: genetic factors, viral infection, and environmental and dietary factors. The types of NPC show strong ethnic and geographic variations. The keratinizing and non-keratinizing types are prevalent in the lower incidence regions like North America and Europe; whereas the undifferentiated type is mostly found in the regions with higher incidences like China, North Africa, Arctic, and Nagaland of North-East India. These suggest a possible major role of the internal genetic factors for generation and promotion of this disease. Viral infections might accelerate the process of carcinogenesis by helping in cellular proliferation and loss of apoptosis. Diet and other environmental factors promote these neoplastic processes and further progression of the disease occurs.

  18. Interaction of higher plant ribosomal 5S RNAs with ''Xenopus laevis'' transcriptional factor IIIA

    International Nuclear Information System (INIS)

    Barciszewska, M.Z.

    1994-01-01

    In this paper transcriptional factor IIIA (TFIIIA) has been used as a probe for identity of three-dimensional-structure of eukaryotic 5S rRNAs. I was interested in finding a common motif in plant and ''Xenopus'' 5S rRNAs for TFIIIA recognition. I found that the two eukaryotic 5S rRNAs (from wheat germ and lupin seeds) are recognized by ''X. laevis'' TFIIIA and the data clearly suggest that these 5S rRNAs have very similar if not identical three-dimensional structures. Also effects of various conditions on stability of these complexes have been studied. (author). 30 refs, 6 figs, 1 tab

  19. Monitoring organic loading to swimming pools by fluorescence excitation–emission matrix with parallel factor analysis (PARAFAC)

    DEFF Research Database (Denmark)

    Seredynska-Sobecka, Bozena; Stedmon, Colin; Boe-Hansen, Rasmus

    2011-01-01

    Fluorescence Excitation–Emission Matrix spectroscopy combined with parallel factor analysis was employed to monitor water quality and organic contamination in swimming pools. The fluorescence signal of the swimming pool organic matter was low but increased slightly through the day. The analysis...... revealed that the organic matter fluorescence was characterised by five different components, one of which was unique to swimming pool organic matter and one which was specific to organic contamination. The latter component had emission peaks at 420nm and was found to be a sensitive indicator of organic...... loading in swimming pool water. The fluorescence at 420nm gradually increased during opening hours and represented material accumulating through the day....

  20. Does vertical integration have an effect on load factor? - A test on coal-fired plants in England and Wales

    International Nuclear Information System (INIS)

    Lopez, Jose A.; Salies, Evens

    2006-02-01

    Today in the British electricity industry, most electricity suppliers hedge a large proportion of their residential customer base requirements by owning their own plant. The non-storability of electricity and the corresponding need for an instantaneous matching of generation and consumption creates a business need for integration. From a sample of half-hour data on load factor for coal-fired power plants in England and Wales, this paper tests the hypothesis that vertical integration with retail businesses affects the extent to which producers utilize their capacity. We also pay attention to this potential effect during periods of peak demand. (authors)

  1. Criatividade na educação superior: fatores inibidores Creativity in higher education: inhibiting factors

    Directory of Open Access Journals (Sweden)

    Eunice Maria Lima Soriano de Alencar

    2010-07-01

    Full Text Available O objetivo deste estudo foi investigar elementos percebidos por professores da educação superior como inibidores à promoção de condições adequadas ao desenvolvimento e expressão da criatividade de seus alunos. Trezentos e trinta e oito professores de instituições públicas e particulares de ensino superior responderam a uma checklist de barreiras à promoção de condições favoráveis à criatividade em sala de aula. Alunos com dificuldades de aprendizagem em sala de aula, desinteresse do aluno pelo conteúdo ministrado, poucas oportunidades para discutir e trocar ideias com colegas de trabalho sobre estratégias instrucionais e elevado número de alunos em sala de aula foram os itens com maior percentual de respostas. Alguns elementos cerceadores foram mais indicados por docentes de instituições públicas e outros por docentes de instituições particulares. Ademais, maior percentual de docentes do gênero feminino, comparativamente ao do gênero masculino, apontou cobrança de aulas expositivas pelos alunos e extensão do programa das disciplinas.The purpose of this study was to investigate the perception of higher education professors regarding inhibiting elements to the promotion of adequate conditions for the development and expression of students' creativity in the classroom. The participants were 338 professors from public and private higher education institutions, who completed a checklist of obstacles to the promotion of creativity in the classroom. Students with learning difficulties, students' lack of interest in the content taught, few opportunities to discuss and exchange ideas with colleagues about instructional strategies and large number of students in the classroom were the items with greater number of responses. Significant differences were observed among professors from public and private institutions of higher education in several items. Furthermore, a greater percentage of female, comparatively to male

  2. Excited baryon form-factors at high momentum transfer at CEBAF at higher energies

    Energy Technology Data Exchange (ETDEWEB)

    Stoler, P. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    1994-04-01

    The possibilities of measuring the properties of excited nucleons at high Q{sup 2} by means of exclusive single meson production at CEBAF with an electron energy of 8 GeV is considered. The motivation is to access short range phenomena in baryon structure, and to investigate the transition from the low Q{sup 2} non-perturbative QCD regime, where constituent quark models are valid, to higher Q{sup 2} where it is believed perturbative QCD plays an increasingly important role. It is found that high quality baryon decay angular distributions can be obtained for the most prominent states up to Q{sup 2} {approximately} 12 GeV{sup 2}/c{sup 2} using a set of moderate resolution, large solid angle magnetic spectrometers.

  3. Demand characteristics and load factor in a sugar cane brandy distillery; Caracteristica de demanda e fator de carga numa destilaria de aguardente

    Energy Technology Data Exchange (ETDEWEB)

    Assumpcao, C R [UNESP, Ilha Solteira, SP (Brazil). Faculdade de Engenharia; Souza, L L.G. [UNESP, Botucatu, SP (Brazil). Faculdade de Ciencias Agronomicas

    1987-12-31

    The actual and calculated load factor values were also confronted for both harvests studied, looking for a polynomial equation that could represent the relationships among the variables. (author) 11 refs., 4 figs., 3 tabs.

  4. Social Cognition and Executive Functions As Key Factors for Effective Pedagogy in Higher Education.

    Science.gov (United States)

    Correia, Rut; Navarrete, Gorka

    2017-01-01

    Higher education (HE) faces the challenge of responding to an increasing diversity. In this context, more attention is being paid to teachers and teaching skills positively related to students learning. Beyond the knowledges identified as key components of an effective teacher, teachers also need to be capable of unraveling what their students think and believe, and how they accommodate the new information. More importantly, teachers need to be able to adapt their own teaching to their audience's needs. In learners, social cognition (SC) has been related to a better receptivity to the different teacher-student interactions. Since these interactions are bidirectional, SC could also help to explain teachers' receptiveness to the information available in feedback situations. However, little is known about how SC is related to teacher development, and therefore teaching effectiveness, in HE. In addition, executive functions (EFs), closely related to SC, could play a key role in the ability to self-regulate their own teaching to better answering their students emerging needs. Although there is wide evidence regarding the association of EFs to performance in high demanding settings, as far as we know, there are no studies exploring the relationship between teachers' EFs and teaching effectiveness in HE. Establishing a positive association between teaching effectiveness and these socio-cognitive functions could be a promising first step in designing professional development programs that promote HE academics' ability to understand and care about students thoughts and emotions, to eventually adapt their teaching to their students needs for a better learning.

  5. Factors in the development of higher levels of reading literacy: Argumentation skills in educational practice

    Directory of Open Access Journals (Sweden)

    Branković Marija

    2013-01-01

    Full Text Available The highest levels of reading literacy, as defined within PISA study, include the ability to use various cognitive skills, with argumentative skills being one of the most important among them. In the present study our goal was to reveal some of the factors that influence the development of argumentative skills in Serbian schools. We investigated the extent to which argumentative skills are required in PISA reading literacy tasks, as well as the specific difficulties our students have faced on these tasks, through an analysis of student performance. We also conducted an analysis of the educational practice - by doing in-depth interviews with teachers and content analysis of students' textbooks. The results revealed that: 1 Argumentations skills are an important requirement within PISA tasks; 2 Serbian students are mostly successful at basic tasks of recognizing arguments or providing arguments for the given position; they face difficulties answering the tasks which require precise formulation of relevant arguments as well as those demanding meta-cognitive skills (e.g. recognizing persuasive strategies in the given text. Their performance is particularly poor on tasks requiring the combination of information from different sources or information presented in different formats (text, tables, or graphs; 3 There is a significant gap between the requirements for argumentation skills our students usually encounter and PISA reading literacy tasks. In this paper we discuss some of the difficulties and obstacles to encouraging the development of argumentative thinking.

  6. The prediction of the impact of climatic factors on short-term electric power load based on the big data of smart city

    Science.gov (United States)

    Qiu, Yunfei; Li, Xizhong; Zheng, Wei; Hu, Qinghe; Wei, Zhanmeng; Yue, Yaqin

    2017-08-01

    The climate changes have great impact on the residents’ electricity consumption, so the study on the impact of climatic factors on electric power load is of significance. In this paper, the effects of the data of temperature, rainfall and wind of smart city on short-term power load is studied to predict power load. The authors studied the relation between power load and daily temperature, rainfall and wind in the 31 days of January of one year. In the research, the authors used the Matlab neural network toolbox to establish the combinational forecasting model. The authors trained the original input data continuously to get the internal rules inside the data and used the rules to predict the daily power load in the next January. The prediction method relies on the accuracy of weather forecasting. If the weather forecasting is different from the actual weather, we need to correct the climatic factors to ensure accurate prediction.

  7. Uniqueness conditions for constrained three-way factor decompositions with linearly dependent loadings

    NARCIS (Netherlands)

    Stegeman, Alwin; De Almeida, Andre L. F.

    2009-01-01

    In this paper, we derive uniqueness conditions for a constrained version of the parallel factor (Parafac) decomposition, also known as canonical decomposition (Candecomp). Candecomp/Parafac (CP) decomposes a three-way array into a prespecified number of outer product arrays. The constraint is that

  8. Comparison of Acceleration and Impact Stress as Possible Loading Factors in Phonation: A Computer Modeling Study

    Czech Academy of Sciences Publication Activity Database

    Horáček, Jaromír; Laukkanen, A. M.; Šidlof, Petr; Murphy, P.; Švec, J. G.

    2009-01-01

    Roč. 61, č. 3 (2009), s. 137-145 ISSN 1021-7762 R&D Projects: GA ČR(CZ) GA101/08/1155 Institutional research plan: CEZ:AV0Z20760514 Keywords : biomechanics of voice modeling * fundamental frequency * phoniation type * gender differences in voice Subject RIV: BI - Acoustics Impact factor: 1.439, year: 2007

  9. Using a latent variable model with non-constant factor loadings to examine PM2.5 constituents related to secondary inorganic aerosols.

    Science.gov (United States)

    Zhang, Zhenzhen; O'Neill, Marie S; Sánchez, Brisa N

    2016-04-01

    Factor analysis is a commonly used method of modelling correlated multivariate exposure data. Typically, the measurement model is assumed to have constant factor loadings. However, from our preliminary analyses of the Environmental Protection Agency's (EPA's) PM 2.5 fine speciation data, we have observed that the factor loadings for four constituents change considerably in stratified analyses. Since invariance of factor loadings is a prerequisite for valid comparison of the underlying latent variables, we propose a factor model that includes non-constant factor loadings that change over time and space using P-spline penalized with the generalized cross-validation (GCV) criterion. The model is implemented using the Expectation-Maximization (EM) algorithm and we select the multiple spline smoothing parameters by minimizing the GCV criterion with Newton's method during each iteration of the EM algorithm. The algorithm is applied to a one-factor model that includes four constituents. Through bootstrap confidence bands, we find that the factor loading for total nitrate changes across seasons and geographic regions.

  10. Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study

    Directory of Open Access Journals (Sweden)

    Zahra Bahadoran

    2015-06-01

    Full Text Available BackgroundIn this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL and protein to potassium (Pro:K ratio, with cardiometabolic risk factors in Tehranian adults.MethodsA cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011 on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C, serum creatinine, and fasting blood glucose.ResultsThe mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001, waist circumference (β=0.062, P<0.01, serum triglycerides (β=0.143, P<0.01, HDL-C (β=-0.11, P<0.01, diastolic blood pressure (β=0.062, P<0.01, and serum creatinine (β=0.142, P<0.001. Pro:K ratio was associated with weight (β=0.055, P<0.001, waist circumference (β=0.04, P<0.01, serum HDL-C (β=-0.06, P<0.01, serum triglycerides (β=0.03, P<0.05, diastolic blood pressure (β=0.026, P<0.05, and serum creatinine (β=0.07, P<0.01.ConclusionA more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

  11. Research Performance of Higher Education Institutions: A Review on the Measurements and Affecting Factors of Research Performance

    Directory of Open Access Journals (Sweden)

    Oya TAMTEKİN AYDIN

    2017-08-01

    Full Text Available Recently, the increasing competition in higher education has attracted attention by many researchers. They have emphasized that the aim of the growing competition between universities is to increase the number of students, the research performance and get research support, find qualified faculty members, and receive financial contributions. This paper aims to draw attention to “research performance” which is a significant part of the competition among the universities. In connection with this goal, the study tries to outline the results of an extensive literature review in the field of higher education research performance. Firstly, literature regarding research performance, its definition as a concept, and its indicators are discussed. Then, the factors influencing research performance are presented in a comprehensive manner. At the end of the study, a conceptual framework that will be useful for all university staff is provided. Understanding the concept of research performance and the factors affecting research performance can help relevant authorities improve their current positions.

  12. Factors Controlling Nitrogen Loadings in Major River Basins Across the United States

    Science.gov (United States)

    Boyer, E. W.; Alexander, R. B.; Galloway, J. N.; Golden, H. E.; Moore, R. B.; Schwarz, G. E.; Harvey, J. W.; Gomez-Velez, J. D.; Scott, D.; Clune, J.

    2017-12-01

    Inputs of reactive nitrogen (all N species except for N2) have been increasing worldwide, largely due to human activities associated with food production and energy consumption via the combustion of fossil fuels and biofuels. Despite the obvious essential benefits of a plentiful supply of food and energy, the adverse consequences associated with the accumulation of N in the environment are large. Most of the N created by human activities is released to the environment, often with unintended negative consequences. The greater the inputs of N to the landscape, the greater the potential for negative effects - caused by greenhouse gas production, ground level ozone, acid deposition, and N overload; which in turn can contribute to climate change, degradation of soils and vegetation, acidification of surface waters, coastal eutrophication, hypoxia, habitat loss, and loss of stratospheric ozone. Here we present a contemporary inventory of reactive N inputs to major water regions in the United States, and discuss accounting methods for quantifying N sources and transport. Furthermore, we quantify loadings of N from terrestrial headwaters downstream to coastal estuaries and embayments. N delivery to downstream waters is influenced by nutrient sources as well as coupled hydrological and biogeochemical processes occurring along the river corridor (e.g., travel time distributions, denitrification, and storage) that scale with stream size and are affected by impoundments such as lakes and reservoirs. This underscores the need to account for the nonlinear interactions of aquatic transport processes with watershed nutrient sources, as well as cumulative effects, in developing efficient nutrient reduction strategies. Our work is useful as a benchmark of the current N situation against which future progress can be assessed in varying water regions of the country; amidst changing N inputs, policies, and management strategies. Our results stem from the EPA Integrated Nitrogen

  13. Khat Chewing among Students of Higher Education in Jazan Region, Saudi Arabia: Prevalence, Pattern, and Related Factors

    OpenAIRE

    Alsanosy, Rashad Mohammed; Mahfouz, Mohamed Salih; Gaffar, Abdelrahim Mutwakel

    2013-01-01

    Objectives. (1) To estimate the prevalence and behavioral patterns of Khat chewing and (2) to investigate factors that influenced the pattern of Khat use among undergraduate students in different higher education institutions in Jazan region, Saudi Arabia. Materials and Methods. A cross-sectional study using a pretested structured self-administered quantitative questionnaire was used to collect data. SPSS version 17 software program was used for data analysis. Results. The overall current Kha...

  14. Separating method factors and higher order traits of the Big Five: a meta-analytic multitrait-multimethod approach.

    Science.gov (United States)

    Chang, Luye; Connelly, Brian S; Geeza, Alexis A

    2012-02-01

    Though most personality researchers now recognize that ratings of the Big Five are not orthogonal, the field has been divided about whether these trait intercorrelations are substantive (i.e., driven by higher order factors) or artifactual (i.e., driven by correlated measurement error). We used a meta-analytic multitrait-multirater study to estimate trait correlations after common method variance was controlled. Our results indicated that common method variance substantially inflates trait correlations, and, once controlled, correlations among the Big Five became relatively modest. We then evaluated whether two different theories of higher order factors could account for the pattern of Big Five trait correlations. Our results did not support Rushton and colleagues' (Rushton & Irwing, 2008; Rushton et al., 2009) proposed general factor of personality, but Digman's (1997) α and β metatraits (relabeled by DeYoung, Peterson, and Higgins (2002) as Stability and Plasticity, respectively) produced viable fit. However, our models showed considerable overlap between Stability and Emotional Stability and between Plasticity and Extraversion, raising the question of whether these metatraits are redundant with their dominant Big Five traits. This pattern of findings was robust when we included only studies whose observers were intimately acquainted with targets. Our results underscore the importance of using a multirater approach to studying personality and the need to separate the causes and outcomes of higher order metatraits from those of the Big Five. We discussed the implications of these findings for the array of research fields in which personality is studied.

  15. Who gets a job after graduation? Factors affecting the early career employment chances of higher education graduates in Poland

    Directory of Open Access Journals (Sweden)

    Mikołaj Jasiński

    2017-12-01

    Full Text Available The massification of higher education in Poland means that many students choose this educational pathway to improve their chances for a good job. Therefore, the labour market outcomes of graduates provide an important perspective for future students, higher education institutions, as well as decision makers at the national level. The Polish Graduate Tracking System (ELA, based on administrative data, is designed to monitor graduates’ outcomes in the labour market by type of studies, higher education institution, as well as individual curricula. Results of the first two years of graduate tracking show that the outcomes vary by study area, but also change over time. While in the first months after graduation, aspects such as prior experience in the labour market and place of residence have a substantial effect on employment chances, in the longer run, they lose their importance relative to other factors.

  16. Khat Chewing among Students of Higher Education in Jazan Region, Saudi Arabia: Prevalence, Pattern, and Related Factors

    Directory of Open Access Journals (Sweden)

    Rashad Mohammed Alsanosy

    2013-01-01

    Full Text Available Objectives. (1 To estimate the prevalence and behavioral patterns of Khat chewing and (2 to investigate factors that influenced the pattern of Khat use among undergraduate students in different higher education institutions in Jazan region, Saudi Arabia. Materials and Methods. A cross-sectional study using a pretested structured self-administered quantitative questionnaire was used to collect data. SPSS version 17 software program was used for data analysis. Results. The overall current Khat chewing prevalence among higher education students was found to be 23.1%, significantly higher among males at 38.5% than among females at 2.1% . Lifetime Khat chewer students were 24.8% for males at 40.5%, significantly higher compared with females at 3.7% . Univariate analysis revealed that the gender of student, smoking status of student, a friend’s smoking, and Khat chewing were associated with a significant high risk of Khat chewing (   for all. Conclusions. The use of Khat trend is increasing among higher education students in Jazan region. A multilevel, value based, comprehensive, and strategic long-term intervention plan is needed. The comprehensive plan may include social interventions geared by creating recreations alternatives and opportunities for youth and a critical review for current authorities’ interventions and services.

  17. Factors affecting the stability of drug-loaded polymeric micelles and strategies for improvement

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Weisai; Li, Caibin; Wang, Zhiyu; Zhang, Wenli, E-mail: zwllz@163.com; Liu, Jianping, E-mail: liujianpingljp@hotmail.com [China Pharmaceutical University, Department of Pharmaceutics (China)

    2016-09-15

    Polymeric micelles (PMs) self-assembled by amphiphilic block copolymers have been used as promising nanocarriers for tumor-targeted delivery due to their favorable properties, such as excellent biocompatibility, prolonged circulation time, favorable particle sizes (10–100 nm) to utilize enhanced permeability and retention effect and the possibility for functionalization. However, PMs can be easily destroyed due to dilution of body fluid and the absorption of proteins in system circulation, which may induce drug leakage from these micelles before reaching the target sites and compromise the therapeutic effect. This paper reviewed the factors that influence stability of micelles in terms of thermodynamics and kinetics consist of the critical micelle concentration of block copolymers, glass transition temperature of hydrophobic segments and polymer–polymer and polymer–cargo interaction. In addition, some effective strategies to improve the stability of micelles were also summarized.Graphical Abstract.

  18. Multiscale Thermohydrologic Model Analyses of Heterogeneity and Thermal-Loading Factors for the Proposed Repository at Yucca Mountain

    International Nuclear Information System (INIS)

    Glascoe, L.G.; Buscheck, T.A.; Gansemer, J.; Sun, Y.; Lee, K.

    2002-01-01

    The MultiScale ThermoHydrologic Model (MSTHM) predicts thermohydrologic (TH) conditions in emplacement drifts and the adjoining host rock throughout the proposed nuclear-waste repository at Yucca Mountain. The MSTHM is a computationally efficient approach that accounts for TH processes occurring at a scale of a few tens of centimeters around individual waste packages and emplacement drifts, and for heat flow at the multi-kilometer scale at Yucca Mountain. The modeling effort presented here is an early investigation of the repository and is simulated at a lower temperature mode and with a different panel loading than the repository currently being considered for license application. We present these recent lower temperature mode MSTHM simulations that address the influence of repository-scale thermal-conductivity heterogeneity and the influence of preclosure operational factors affecting thermal-loading conditions. We can now accommodate a complex repository layout with emplacement drifts lying in non-parallel planes using a superposition process that combines results from multiple mountain-scale submodels. This development, along with other improvements to the MSTHM, enables more rigorous analyses of preclosure operational factors. These improvements include the ability to (1) predict TH conditions on a drift-by-drift basis, (2) represent sequential emplacement of waste packages along the drifts, and (3) incorporate distance- and time-dependent heat-removal efficiency associated with drift ventilation. Alternative approaches to addressing repository-scale thermal-conductivity heterogeneity are investigated. We find that only one of the four MSTHM submodel types needs to incorporate thermal-conductivity heterogeneity. For a particular repository design, we find that the most influential parameters are (1) percolation-flux distribution, (2) thermal-conductivity heterogeneity within the host-rock units, (3) the sequencing of waste-package emplacement, and (4) the

  19. A hybrid filter to mitigate harmonics caused by nonlinear load and resonance caused by power factor correction capacitor

    Science.gov (United States)

    Adan, N. F.; Soomro, D. M.

    2017-01-01

    Power factor correction capacitor (PFCC) is commonly installed in industrial applications for power factor correction (PFC). With the expanding use of non-linear equipment such as ASDs, power converters, etc., power factor (PF) improvement has become difficult due to the presence of harmonics. The resulting capacitive impedance of the PFCC may form a resonant circuit with the source inductive reactance at a certain frequency, which is likely to coincide with one of the harmonic frequency of the load. This condition will trigger large oscillatory currents and voltages that may stress the insulation and cause subsequent damage to the PFCC and equipment connected to the power system (PS). Besides, high PF cannot be achieved due to power distortion. This paper presents the design of a three-phase hybrid filter consisting of a single tuned passive filter (STPF) and shunt active power filter (SAPF) to mitigate harmonics and resonance in the PS through simulation using PSCAD/EMTDC software. SAPF was developed using p-q theory. The hybrid filter has resulted in significant improvement on both total harmonic distortion for voltage (THDV) and total demand distortion for current (TDDI) with maximum values of 2.93% and 9.84% respectively which were within the recommended IEEE 519-2014 standard limits. Regarding PF improvement, the combined filters have achieved PF close to desired PF at 0.95 for firing angle, α values up to 40°.

  20. Drift Reliability Assessment of a Four Storey Frame Residential Building Under Seismic Loading Considering Multiple Factors

    Science.gov (United States)

    Sil, Arjun; Longmailai, Thaihamdau

    2017-09-01

    The lateral displacement of Reinforced Concrete (RC) frame building during an earthquake has an important impact on the structural stability and integrity. However, seismic analysis and design of RC building needs more concern due to its complex behavior as the performance of the structure links to the features of the system having many influencing parameters and other inherent uncertainties. The reliability approach takes into account the factors and uncertainty in design influencing the performance or response of the structure in which the safety level or the probability of failure could be ascertained. This present study, aims to assess the reliability of seismic performance of a four storey residential RC building seismically located in Zone-V as per the code provisions given in the Indian Standards IS: 1893-2002. The reliability assessment performed by deriving an explicit expression for maximum roof-lateral displacement as a failure function by regression method. A total of 319, four storey RC buildings were analyzed by linear static method using SAP2000. However, the change in the lateral-roof displacement with the variation of the parameters (column dimension, beam dimension, grade of concrete, floor height and total weight of the structure) was observed. A generalized relation established by regression method which could be used to estimate the expected lateral displacement owing to those selected parameters. A comparison made between the displacements obtained from analysis with that of the equation so formed. However, it shows that the proposed relation could be used directly to determine the expected maximum lateral displacement. The data obtained from the statistical computations was then used to obtain the probability of failure and the reliability.

  1. Lipid-load in peripheral blood mononuclear cells: Impact of food-consumption, dietary-macronutrients, extracellular lipid availability and demographic factors.

    Science.gov (United States)

    Ameer, Fatima; Munir, Rimsha; Usman, Hina; Rashid, Rida; Shahjahan, Muhammad; Hasnain, Shahida; Zaidi, Nousheen

    2017-04-01

    Lipid-load in peripheral blood mononuclear cells (PBMCs) has recently gained attention of the researchers working on nutritional regulation of metabolic health. Previous works have indicated that the metabolic circuitries in the circulating PBMCs are influenced by dietary-intake and macronutrient composition of diet. In the present work, we analyzed the impact of diet and dietary macronutrients on PBMCs' lipid-load. The overall analyses revealed that dietary carbohydrates and fats combinatorially induce triglyceride accumulation in PBMCs. On the other hand, dietary fats were shown to induce significant decrease in PBMCs' cholesterol-load. The effects of various demographic factors -including age, gender and body-weight- on PBMCs' lipid-load were also examined. Body-weight and age were both shown to affect PBMC's lipid-load. Our study fails to provide any direct association between extracellular lipid availability and cholesterol-load in both, freshly isolated and cultured PBMCs. The presented work significantly contributes to the current understanding of the impact of food-consumption, dietary macronutrients, extracellular lipid availability and demographic factors on lipid-load in PBMCs. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  2. Higher HOMA-IR index and correlated factors of insulin resistance in patients with IgA nephropathy.

    Science.gov (United States)

    Yang, Yue; Wei, Ri-Bao; Wang, Yuan-da; Zhang, Xue-Guang; Rong, Na; Tang, Li; Chen, Xiang-Mei

    2012-11-01

    To investigate the index of homeostasis model of insulin resistance (HOMA-IR) in IgA nephropathy (IgAN) patients, and to explore the possible correlated factors contributing to insulin resistance (IR) within these patients. There were 255 IgAN patients and 45 membranous nephropathy (MN) patients in our database. We identified 89 IgAN subjects and 21 MN subjects without diabetes and undergoing glucocorticoid therapy for at least 6 months. Data regarding physical examination, blood chemistry and renal pathology were collected from 89 IgAN subjects and 21 MN subjects. Then 62 IgAN patients and 19 MN patients with chronic kidney disease (CKD) Stage 1 - 2 were selected for the comparison of HOMA-IR index, 89 IgAN patients were selected for multiple regression analysis to test for correlated factors of HOMA-IR index with IgAN patients. Comparison between IgAN and MN show that HOMA-IR index was significantly higher in IgAN patients with CKD Stage 1 - 2. After logarithmic transformation with urine protein (UPr), Ln(UPr) (b = 0.186, p = 0.008), eGFR (b = -0.005, p = 0.014), > 50% of glomeruli with mesangial hypercellularity (b = 0.285, p = 0.027) and body mass index (BMI) (b = 0.039, p = 0.008) were correlated factors of HOMA-IR index in the multiple regression analysis. IgAN patients had higher HOMA-IR index compared with MN in the stages of CKD 1 - 2. For IgAN patients, more UPr, lower eGFR, > 50% of glomeruli with mesangial hypercellularity and higher BMI were correlated with IR.

  3. Shot loading platform analysis

    International Nuclear Information System (INIS)

    Norman, B.F.

    1994-01-01

    This document provides the wind/seismic analysis and evaluation for the shot loading platform. Hand calculations were used for the analysis. AISC and UBC load factors were used in this evaluation. The results show that the actual loads are under the allowable loads and all requirements are met

  4. A ORACLE-based system for data collection, storage and analysis of main equipment load factors in NPPs and TPPs

    International Nuclear Information System (INIS)

    Ivanova, L.

    1993-01-01

    This data base is developed by the National Electricity Company, Sofia (BG) as an aid to supervision, analysis and administration decision making in a variety of operational situations in NPPs and TPPs. As major indicators of the equipment condition the following primary data are stored: steam or electricity production per month; operation hours per month; equipment stand-by outages; planned outages; unplanned permitted maintenance outages; unplanned emergency maintenance outages; number of outages of the unit per month. These data cover the period from the putting of the corresponding equipment into operation till the present moment, i.e. or about 32 years. The data up to 1990 are annual and for the last three years - monthly. Based on these primary data, the following quantities are calculated: average capacity; average load factors; operation time factors - total and accounting for the planned and the permitted unplanned outages; unpermitted outages factors - total and accounting for the planned and the permitted outages. All the factors are calculated on user's request for a chosen time period, by summing up correspondingly the major indicators (production, operation hours and various outages) for the given period. The system operates on an IBM 4341 under VM/SP and DB ORACLE V.5. The input is entered directly from the TPP and NPP by telex lines from PCs, operating also as telex machines, into the mainframe of Energokibernetika Ltd. They are available to all authorised users from local terminals or PCs, connected to the computer by synchronous or asynchronous lines. A system for data transmission to remote users along commutated telephone lines is also developed. (R. Ts.)

  5. Are Fit Indices Biased in Favor of Bi-Factor Models in Cognitive Ability Research?: A Comparison of Fit in Correlated Factors, Higher-Order, and Bi-Factor Models via Monte Carlo Simulations

    Directory of Open Access Journals (Sweden)

    Grant B. Morgan

    2015-02-01

    Full Text Available Bi-factor confirmatory factor models have been influential in research on cognitive abilities because they often better fit the data than correlated factors and higher-order models. They also instantiate a perspective that differs from that offered by other models. Motivated by previous work that hypothesized an inherent statistical bias of fit indices favoring the bi-factor model, we compared the fit of correlated factors, higher-order, and bi-factor models via Monte Carlo methods. When data were sampled from a true bi-factor structure, each of the approximate fit indices was more likely than not to identify the bi-factor solution as the best fitting. When samples were selected from a true multiple correlated factors structure, approximate fit indices were more likely overall to identify the correlated factors solution as the best fitting. In contrast, when samples were generated from a true higher-order structure, approximate fit indices tended to identify the bi-factor solution as best fitting. There was extensive overlap of fit values across the models regardless of true structure. Although one model may fit a given dataset best relative to the other models, each of the models tended to fit the data well in absolute terms. Given this variability, models must also be judged on substantive and conceptual grounds.

  6. Factors influencing the intention to use social media for work-related purposes at a South African higher education institution

    Directory of Open Access Journals (Sweden)

    Liezel Cilliers

    2017-07-01

    Full Text Available Orientation: The rapid development of information communication technology (ICT has changed much of contemporary society. ICT’s influence extends to the working context with ramifications not only for employees but also for the entire organisation. Research purpose: The primary purpose of this research was to investigate the behavioural intention of a sample of employees at a traditional higher education institution to make use of social media within the workplace. Motivation for the study: Social media has become a common tool within society for communication and networking purposes. An understanding of the factors that influence behavioural intention to use social media within the workplace can assist the organisation to better manage social media usage within the workplace. Research design, approach and method: The research adopted the positivism paradigm with a quantitative research approach. The data were analysed making use of exploratory factor analysis and multiple regression analysis. A traditional higher education institution was chosen as the research site for the study, relying on a convenience sample (n = 134 and data gathered using the work-related social media scale and behavioural intention to use scale. Main findings: Although most employees make use of social media for problem-solving and communication purposes already in the workplace, organisations should allow their employees to help manage their reputation on social media. Practical and managerial implications: An understanding of the factors that influence behavioural intention to use social media within the workplace can serve as a useful precursor for both employee and organisational-specific interventions. This study has specific relevance to the use of ICT platforms, such as social media, in traditional higher education institutions in South Africa. The study’s results are therefore useful to both employees as end-users and managers as drivers of such interventions

  7. Optimization of 10 kW solar photovoltaic – diesel generator hybrid energy system for different load factors at Jaisalmer location of Rajasthan, India

    Science.gov (United States)

    Saraswat, S. K.; Rao, K. V. S.

    2018-03-01

    Jaisalmer town in Rajasthan, India is having annual average solar insolation of 5.80 kWh/m2/day and 270 – 300 clear sky days in a year. A 10 kW off-grid hybrid energy system (HES) consisting of solar photovoltaic panels – diesel generator – bidirectional converter and batteries with zero percentage loss of load for Jaisalmer is designed using HOMER (version 3.4.3) software. Different system load factors of 0.33, 0.50, 0.67, 0.83 and 1 corresponding to fraction of running hours per day of the system are considered. The system is analyzed for all three aspects, namely, electrical, economic and emission point of view. Least levelized cost of electricity (LCOE) of Rs. 8.43/kWh is obtained at a load factor value of 0.5. If diesel generator alone (without Solar PV) is used to fulfil the demand for a load factor of 0.5the value of LCOE is obtained Rs.19.23/kWh. Comparison of results obtained for HES and diesel generator are made for load factor of 0.5 and 1.

  8. Higher Education End-of-Course Evaluations: Assessing the Psychometric Properties Utilizing Exploratory Factor Analysis and Rasch Modeling Approaches

    Directory of Open Access Journals (Sweden)

    Kelly D. Bradley

    2016-07-01

    Full Text Available This paper offers a critical assessment of the psychometric properties of a standard higher education end-of-course evaluation. Using both exploratory factor analysis (EFA and Rasch modeling, the authors investigate the (a an overall assessment of dimensionality using EFA, (b a secondary assessment of dimensionality using a principal components analysis (PCA of the residuals when the items are fit to the Rasch model, and (c an assessment of item-level properties using item-level statistics provided when the items are fit to the Rasch model. The results support the usage of the scale as a supplement to high-stakes decision making such as tenure. However, the lack of precise targeting of item difficulty to person ability combined with the low person separation index renders rank-ordering professors according to minuscule differences in overall subscale scores a highly questionable practice.

  9. The influence of biotic and abiotic factors on (137)Cs accumulation in higher fungi after the accident at Chernobyl NPP.

    Science.gov (United States)

    Zarubina, N

    2016-09-01

    Levels of soil contamination with (137)Cs, the belonging of fungi to a certain ecological group, the localization depth of the main part of mycelium in soil are the primary factors influencing the value of (137)Cs specific activity in higher fungi after the accident at Chernobyl NPP. It has been found that the value of (137)Cs specific activity in fungi of one species could vary by more than 10 times during a vegetation period. A correlation between the changes of (137)Cs content in fungi during the vegetation period and the amount of precipitates during various periods preceding the collection of samples has not been determined. An assumption has been proposed stating dependence between peculiarities of mycelium growth during the vegetation period and the changes of (137)Cs specific activity in fungi. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. An empirical study of factors influencing adoption of Internet banking among students of higher education: Evidence from Pakistan

    Directory of Open Access Journals (Sweden)

    Abdul Kabeer Kazi

    2013-05-01

    Full Text Available Thispaper investigated the influence of factors on the intention to adopt Internetbanking services among students of higher education in Pakistan. Theoreticalframework used for this study has been adopted from Technology Acceptance Model(TAM with four independent variables. Convenience sampling method was usedwith a total of valid 220 respondents, which included students of Khadim AliShah Bukhari Institute of Technology (KASBIT, Karachi, Pakistan.  Data was collected through self administeredquestionnaire of two parts: Demographic and Likert scale multi-item scale forvariables under study. Results indicated that convenience, perceivedcredibility, and perceived usefulness had significant positive influence amongstudents on the intention to adopt Internet banking. The findings from thisresearch would be useful for banks in the subject area, particularly forstudents in Pakistan.

  11. Increased Tumor Necrosis Factor (TNF)-α and Its Promoter Polymorphisms Correlate with Disease Progression and Higher Susceptibility towards Vitiligo

    Science.gov (United States)

    Laddha, Naresh C.; Dwivedi, Mitesh; Begum, Rasheedunnisa

    2012-01-01

    Abstract Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as abnormal immune responses have frequently been observed in vitiligo patients. Moreover, vitiligo patients show higher lesion levels of TNF-α. Genetic polymorphisms in the promoter region of TNF-α are involved in the regulation of its expression. The present study explores TNF-α promoter polymorphisms and correlates them with TNF-α transcript and protein levels in vitiligo patients and controls of Gujarat along with its effect on disease onset and progression. PCR-RFLP technique was used for genotyping of these polymorphisms in 977 vitiligo patients and 990 controls. TNF-α transcript and protein levels were measured by Real time PCR and ELISA respectively. The genotype and allele frequencies for the investigated polymorphisms were significantly associated with vitiligo patients. The study revealed significant increase in TNF-α transcript and protein levels in vitiligo patients compared to controls. In particular, haplotypes: AATCC, AACCT, AGTCT, GATCT, GATCC and AGCCT were found to increase the TNF-α levels in vitiligo patients. Analysis of TNF-α levels based on the gender and disease progression suggests that female patients and patients with active vitiligo had higher levels of TNF-α. Also, the TNF-α levels were high in patients with generalized vitiligo as compared to localized vitiligo. Age of onset analysis of the disease suggests that the haplotypes: AACAT, AACCT, AATCC and AATCT had a profound effect in the early onset of the disease. Moreover, the analysis suggests that female patients had an early onset of vitiligo. Overall, our results suggest that TNF-α promoter polymorphisms may be genetic risk factors for susceptibility and progression of the disease. The up-regulation of TNF-α transcript and protein levels in individuals with susceptible haplotypes advocates

  12. Regulation of the Dynamic Live Load Factor for Calculation of Bridge Structures on High-Speed Railway Mainlines

    Science.gov (United States)

    Dyachenko, Leonid K.; Benin, Andrey V.

    2017-06-01

    When the high-speed railway traffic is being organized, it becomes necessary to elaborate bridge design standards for high-speed railways (HSR). Methodology of studying the issues of HSR bridge design is based on the comprehensive analysis of domestic research as well as international experience in design, construction and operation of high-speed railways. Serious requirements are imposed on the HSR artificial structures, which raise a number of scientific tasks associated mainly with the issues of the dynamic interaction of the rolling stock and the bridge elements. To ensure safety of traffic and reliability of bridges during the whole period of operation one needs to resolve the dynamic problems of various types of high-speed trains moving along the structures. The article analyses dependences of the magnitude of inertial response on the external stress parameters and proposes a simplified method of determination of the dynamic live load factor caused by the passage of high-speed trains. The usefulness of the given research arises from the reduction of complexity of the complicated dynamic calculations needed to describe a high-speed train travelling along the artificial structures.

  13. Regulation of the Dynamic Live Load Factor for Calculation of Bridge Structures on High-Speed Railway Mainlines

    Directory of Open Access Journals (Sweden)

    Dyachenko Leonid K.

    2017-06-01

    Full Text Available When the high-speed railway traffic is being organized, it becomes necessary to elaborate bridge design standards for high-speed railways (HSR. Methodology of studying the issues of HSR bridge design is based on the comprehensive analysis of domestic research as well as international experience in design, construction and operation of high-speed railways. Serious requirements are imposed on the HSR artificial structures, which raise a number of scientific tasks associated mainly with the issues of the dynamic interaction of the rolling stock and the bridge elements. To ensure safety of traffic and reliability of bridges during the whole period of operation one needs to resolve the dynamic problems of various types of high-speed trains moving along the structures. The article analyses dependences of the magnitude of inertial response on the external stress parameters and proposes a simplified method of determination of the dynamic live load factor caused by the passage of high-speed trains. The usefulness of the given research arises from the reduction of complexity of the complicated dynamic calculations needed to describe a high-speed train travelling along the artificial structures.

  14. Key health promotion factors among male members of staff at a higher educational institution: A cross-sectional postal survey

    Directory of Open Access Journals (Sweden)

    Reid Garth

    2008-02-01

    Full Text Available Abstract Background Men's lifestyles are generally less healthy than women's. This study identifies associations between health-related behaviour in different groups of men working in a Higher Education (HE institution. In addition, men were asked whether they regarded their health-related behaviours as a concern. This article highlights smoking, consumption of alcohol and physical activity as most common men's health-related lifestyle behaviours. Methods A descriptive cross-sectional survey was conducted among all male staff employed by a Higher Education institute in Scotland using a postal self-completed questionnaire. A total of 1,335 questionnaires were distributed and 501 were returned completed (38% return rate. The data were analysed using SPSS 13.0 for Windows. Results Less than 10% currently smoked and almost 44% of these smokers were light smokers. Marital status, job title, consumption of alcohol and physical activity level were the major factors associated with smoking behaviour. Men in manual jobs were far more likely to smoke. Nearly all (90% consumed alcohol, and almost 37% had more than recommended eight units of alcohol per day at least once a week and 16% had more than 21 units weekly. Younger men reported higher amount of units of alcohol on their heaviest day and per week. Approximately 80% were physically active, but less than 40% met the current Government guidelines for moderate physical activity. Most men wanted to increase their activity level. Conclusion There are areas of health-related behaviour, which should be addressed in populations of this kind. Needs assessment could indicate which public health interventions would be most appropriately aimed at this target group. However, the low response rate calls for some caution in interpreting our findings.

  15. Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration.

    Science.gov (United States)

    Yu, Ting; Xu, Bei; He, Lili; Xia, Shan; Chen, Yan; Zeng, Jun; Liu, Yongmei; Li, Shuangzhi; Tan, Xiaoyue; Ren, Ke; Yao, Shaohua; Song, Xiangrong

    2016-01-01

    Anti-angiogenesis has been proposed as an effective therapeutic strategy for cancer treatment. Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous anti-angiogenic reagents discovered to date and PEDF gene therapy has been recognized as a promising treatment option for various tumors. There is an urgent need to develop a safe and valid vector for its systemic delivery. Herein, a novel gene delivery system based on the newly synthesized copolymer COOH-PEG-PLGA-COOH (CPPC) was developed in this study, which was probably capable of overcoming the disadvantages of viral vectors and cationic lipids/polymers-based nonviral carriers. PEDF gene loaded CPPC nanoparticles (D-NPs) were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W) solvent evaporation method. D-NPs with uniform spherical shape had relatively high drug loading (~1.6%), probably because the introduced carboxyl group in poly (D,L-lactide-co-glycolide) terminal enhanced the interaction of copolymer with the PEDF gene complexes. An excellent in vitro antitumor effect was found in both C26 and A549 cells treated by D-NPs, in which PEDF levels were dramatically elevated due to the successful transfection of PEDF gene. D-NPs also showed a strong inhibitory effect on proliferation of human umbilical vein endothelial cells in vitro and inhibited the tumor-induced angiogenesis in vivo by an alginate-encapsulated tumor cell assay. Further in vivo antitumor investigation, carried out in a C26 subcutaneous tumor model by intravenous injection, demonstrated that D-NPs could achieve a significant antitumor activity with sharply reduced microvessel density and significantly promoted tumor cell apoptosis. Additionally, the in vitro hemolysis analysis and in vivo serological and biochemical analysis revealed that D-NPs had no obvious toxicity. All the data indicated that the novel CPPC nanoparticles were ideal vectors for the systemic delivery of PEDF gene and might be widely

  16. The analysis of loading losses from tank trucks

    Directory of Open Access Journals (Sweden)

    Jovanović Ana P.

    2006-01-01

    Full Text Available The quantity of loading losses, which are the primary source of evaporative emissions from tank cars and trucks was analyzed in this paper. Loading losses occur as organic vapors in "empty" cargo tanks are displaced to the atmosphere by the liquid being loaded into the tanks. Emissions from loading petroleum liquid were estimated using three methods: the API (American Petroleum Institute method, the VDI (Verein Deutscher Ingenieure -Association of German Engineers method and the Yugoslav Standard JUS B.HO.531 method. The mass of evaporative losses from loading operations is a function of the following parameters: the method of loading the cargo, the physical and chemical characteristics of the cargo and the ambient temperature during loading. Evaporation losses from the loading of motor gasoline (MB-95, BMB-95, MB-98 and MB-86 and diesel fuels (D-2, Euro D-2 were calculated. Losses on a monthly and annual basis were presented for an assumed amount of loaded cargo. It was estimated that the highest loading losses occur in the summer period because of high ambient daily temperatures and in the period of higher transporting levels. It should be pointed out that the loading losses of diesel fuel calculated using an empirical coefficient according to JUS B.HO.531 are significantly higher in comparison with the loading losses calculated using emission factors from the EPA and the VDI method. The gasoline loading losses calculated using emission factors derived from the three methods are similar.

  17. Geometrically nonlinear resonance of higher-order shear deformable functionally graded carbon-nanotube-reinforced composite annular sector plates excited by harmonic transverse loading

    Science.gov (United States)

    Gholami, Raheb; Ansari, Reza

    2018-02-01

    This article presents an attempt to study the nonlinear resonance of functionally graded carbon-nanotube-reinforced composite (FG-CNTRC) annular sector plates excited by a uniformly distributed harmonic transverse load. To this purpose, first, the extended rule of mixture including the efficiency parameters is employed to approximately obtain the effective material properties of FG-CNTRC annular sector plates. Then, the focus is on presenting the weak form of discretized mathematical formulation of governing equations based on the variational differential quadrature (VDQ) method and Hamilton's principle. The geometric nonlinearity and shear deformation effects are considered based on the von Kármán assumptions and Reddy's third-order shear deformation plate theory, respectively. The discretization process is performed via the generalized differential quadrature (GDQ) method together with numerical differential and integral operators. Then, an efficient multi-step numerical scheme is used to obtain the nonlinear dynamic behavior of the FG-CNTRC annular sector plates near their primary resonance as the frequency-response curve. The accuracy of the present results is first verified and then a parametric study is presented to show the impacts of CNT volume fraction, CNT distribution pattern, geometry of annular sector plate and sector angle on the nonlinear frequency-response curve of FG-CNTRC annular sector plates with different edge supports.

  18. Calculating load factors for the transatlantic airline market using supply and demand data: a note on the identification of gaps in the available airline statistics

    NARCIS (Netherlands)

    Devriendt, L.; Burghouwt, G.; Derudder, B.; de Wit, J.; Witlox, F.

    2009-01-01

    This paper takes a critical view of the verification of load factors for the direct transatlantic airline market by combining supply and demand-data. The supply-related data originate from the Official Airline Guide, a well-known data source that contains information on scheduled flights. The

  19. Factors influencing storm-generated suspended-sediment concentrations and loads in four basins of contrasting land use, humid-tropical Puerto Rico

    Science.gov (United States)

    A. C. Gellis; NO-VALUE

    2013-01-01

    The significant characteristics controlling the variability in storm-generated suspended-sediment loads and concentrations were analyzed for four basins of differing land use (forest, pasture, cropland, and urbanizing) in humid-tropical Puerto Rico. Statistical analysis involved stepwise regression on factor scores. The explanatory variables were attributes of flow,...

  20. Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants

    Directory of Open Access Journals (Sweden)

    Pao-Hwa Lin

    2012-06-01

    Full Text Available Background: The clinical significance of glycemic index (GI and glycemic load (GL is inconclusive. Objective : This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD risk factors including body weight, blood pressure (BP, serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC change only (p<0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L with a significant age interaction. The GL change was significantly associated with TC (p=0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L positively and with low density lipoprotein cholesterol (LDL-C changes negatively (p=0.03, β = − 0.01±0.00 mg/dL or −0.00±0.00 mmol/L, and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

  1. Factors affecting the potential of direct load control for non-generating utilities. Final report. [Distribution and wholesale power supply interaction

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-01

    Several alternatives are available for achieving load management, including direct or voluntary control of customer loads, customer or utility energy storage systems for diurnal load shifting, and expanded interconnection and operation of electric power systems. All of these alternatives are available to the fully integrated (generating, transmitting and distributing) electric utility and the analysis of their effects encompasses the power supply and delivery system. However, the costs and benefits of the alternatives to the fully integrated electric utility are perhaps not so obvious. Therefore, by considering a non-generating utility, this analysis focuses upon the distribution system and wholesale power supply interaction as a step toward an analysis including the power supply and delivery system. This report develops an analysis procedure and discusses some of the relevant factors to be consdered in the application of direct load control for a non-generating utility system. The analysis concentrates on the distribution system only to determine the effect of rates and payback as a result of direct load control. Thus, the study is responsive to the specific needs of the non-generating utility. This analysis of direct load control encompasses the determination of those loads amenable to control, the selection of a suitable one-way communications system to rend control and the estimation of expected benefits and costs. The complementary functions to the application of direct load control such as automatic meter reading via the addition of a bi-directional communications system and voltage control are not included in the analysis but are detailed for future consideration.

  2. Factores que inciden en el financiamiento de los estudios Universitarios en Chile Factors that impact on funding for higher education in Chile

    Directory of Open Access Journals (Sweden)

    Rodolfo Schmal

    2007-06-01

    Full Text Available El artículo da cuenta de los principales factores que inciden en el financiamiento de los estudios universitarios en Chile, exponiéndose los fundamentos y relaciones de un modelo para estimar el volumen de los recursos comprometidos y sus opciones de provisión. En las últimas dos década el mercado universitario ha duplicando su masa de estudiantes fenómeno que continuará por esta senda, implicando serias presiones sobre el financiamiento público, en un sistema que ya tiene una elevada participación financiera privada. El modelo que se propone apunta a proveer un enfoque sistémico para abordar la problemática planteada.The article covers the main factors that impact on funding higher education in Chile, presenting the fundaments and relations of a model to estimate the volume of resources committed and options for provision. In the last two decades the university market has doubled its total of students - a phenomenon that should continue, entailing serious pressures on public funding. The model proposed here points to a systems approach to the problem.

  3. Effect of operational factors on bioregeneration of binary phenol and 4-chlorophenol-loaded granular activated carbon using PVA-immobilized biomass cryogels.

    Science.gov (United States)

    Leong, Kwok-Yii; Adnan, Rohana; Lim, Poh-Eng; Ng, Si-Ling; Seng, Chye-Eng

    2017-09-01

    The effects of dry biomass density in cryogel beads, shaking speed and initial concentration ratio of phenol to 4-chlorophenol (4-CP) on the bioregeneration efficiencies of binary phenol and 4-CP-loaded granular activated carbon (GAC) for phenol and 4-CP, respectively, were investigated under the simultaneous adsorption and biodegradation approach. The results revealed higher bioregeneration efficiencies of binary-loaded GAC for phenol and 4-CP at higher dry biomass density but moderate shaking speed. The optimum dry biomass density in cryogel beads and shaking speed for use in bioregeneration were found to be 0.01 g/mL and 250 rpm, respectively. With respect to the initial phenol to 4-CP concentration ratio, the bioregeneration efficiencies were lower under increasing phenol and 4-CP initial concentrations, respectively, with the effect being more conspicuous under increasing 4-CP concentration. Higher bioregeneration efficiencies were achieved with the use of immobilized rather than suspended biomasses.

  4. Is it Purposeful for Students of Lithuanian Higher Schools to Continue Learning the English Language? Motivation Factors

    Directory of Open Access Journals (Sweden)

    Ramunė Ilgūnaitienė

    2015-06-01

    Full Text Available After Lithuania had regained its independence the policy of foreign languages teaching/learning at secondary schools changed cardinally. The majority or former school leavers do not perceive it to be purposeful and meaningful to prolong the English language learning on the university or college level. According to them, having covered the secondary school programme they possess a full baggage of the English language knowledge allowing them to communicate fluently in the above mentioned language while travelling, studying and working in foreign countries. Does this belief correspond to the reality of today? The article is based on four factors which are supposed to motivate freshmen and senior students to go on learning the English language as the main tool to enhance their position in contemporary world irreversibly affected by massive globalization and Eurointegration processes. VDU UKI in spring semester of 2014 carried out a research. The questionnaire was compiled the goal of which was to determine whether the English language level of the students matches all the international requirements for the language awareness and present the motives for students to continue the English language studies on a higher level. 172 first year students of various programmes participated in the research. The principle points of the questionnaire sought to provide answers to the following questions: whether the level of the English language acquirement is sufficient after having covered the secondary school programme, if VDU UKI English language teaching/learning policy enables students to acquire the language on a higher level, whether a language is a living, thus a constantly changing organism which requires progressive studies and refreshment of knowledge, if the level of language acquisition remains on the same level if it is not exploited on daily basis. Having systematized the questionnaire results the authoresses of the article draw the conclusion for

  5. Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration

    Directory of Open Access Journals (Sweden)

    Yu T

    2016-02-01

    Full Text Available Ting Yu,1,* Bei Xu,1,* Lili He,2 Shan Xia,3 Yan Chen,1 Jun Zeng,1 Yongmei Liu,1 Shuangzhi Li,1 Xiaoyue Tan,4 Ke Ren,1 Shaohua Yao,1 Xiangrong Song1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, 2College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, 3Central Laboratory, Science Education Department, Chengdu Normal University, Chengdu, Sichuan, 4Department of Pathology/Collaborative Innovation Center of Biotherapy, Medical School of Nankai University, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: Anti-angiogenesis has been proposed as an effective therapeutic strategy for cancer treatment. Pigment epithelium-derived factor (PEDF is one of the most powerful endogenous anti-angiogenic reagents discovered to date and PEDF gene therapy has been recognized as a promising treatment option for various tumors. There is an urgent need to develop a safe and valid vector for its systemic delivery. Herein, a novel gene delivery system based on the newly synthesized copolymer COOH-PEG-PLGA-COOH (CPPC was developed in this study, which was probably capable of overcoming the disadvantages of viral vectors and cationic lipids/polymers-based nonviral carriers. PEDF gene loaded CPPC nanoparticles (D-NPs were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W solvent evaporation method. D-NPs with uniform spherical shape had relatively high drug loading (~1.6%, probably because the introduced carboxyl group in poly (D,L-lactide-co-glycolide terminal enhanced the interaction of copolymer with the PEDF gene complexes. An excellent in vitro antitumor effect was found in both C26 and A549 cells treated by D-NPs, in which PEDF levels were dramatically elevated due to the successful transfection of PEDF gene. D-NPs also showed a strong inhibitory effect on

  6. Social factors and television use during meals and snacks is associated with higher BMI among pre-school children.

    Science.gov (United States)

    Dubois, Lise; Farmer, Anna; Girard, Manon; Peterson, Kelly

    2008-12-01

    The present paper examines the relationship between social factors, food consumption during television viewing, and overall television viewing and how these are associated with BMI when the role of familial and social factors are considered in a population-based birth cohort of pre-school children from Québec (Canada). The analyses were performed using data from the Longitudinal Study of Child Development in Québec (1998-2002) (LSCDQ). The study follows a representative sample (n 2103) of children born in 1998 in the Canadian province of Québec. A nutrition assessment was conducted on 1549 children aged 4.5 years and included a 24 h dietary recall, an eating behaviour and television viewing questionnaire, and a measurement of children's heights and weights. Statistical analyses were performed. Nearly one-quarter of children ate at least twice daily in front of the television. Children who consumed snacks while watching television on a daily basis had higher BMI than children who did so less frequently. Children who ate snacks in front of the television every day, or some times during the week, ate more carbohydrates (total), more fat and less protein, fewer fruits and vegetables, and drank soft drinks more often than children who never ate snacks in front of the television. Health professionals should target parents of children at risk of overweight/obesity with focused strategies to help children change the types of foods consumed during television viewing and to reduce the time spent watching television, particularly during meal times, which may change children's dietary intake and eating patterns.

  7. Perceptual load in different regions of the visual scene and its relevance for driving.

    Science.gov (United States)

    Marciano, Hadas; Yeshurun, Yaffa

    2015-06-01

    The aim of this study was to better understand the role played by perceptual load, at both central and peripheral regions of the visual scene, in driving safety. Attention is a crucial factor in driving safety, and previous laboratory studies suggest that perceptual load is an important factor determining the efficiency of attentional selectivity. Yet, the effects of perceptual load on driving were never studied systematically. Using a driving simulator, we orthogonally manipulated the load levels at the road (central load) and its sides (peripheral load), while occasionally introducing critical events at one of these regions. Perceptual load affected driving performance at both regions of the visual scene. Critically, the effect was different for central versus peripheral load: Whereas load levels on the road mainly affected driving speed, load levels on its sides mainly affected the ability to detect critical events initiating from the roadsides. Moreover, higher levels of peripheral load impaired performance but mainly with low levels of central load, replicating findings with simple letter stimuli. Perceptual load has a considerable effect on driving, but the nature of this effect depends on the region of the visual scene at which the load is introduced. Given the observed importance of perceptual load, authors of future studies of driving safety should take it into account. Specifically, these findings suggest that our understanding of factors that may be relevant for driving safety would benefit from studying these factors under different levels of load at different regions of the visual scene. © 2014, Human Factors and Ergonomics Society.

  8. [Estimation of urban non-point source pollution loading and its factor analysis in the Pearl River Delta].

    Science.gov (United States)

    Liao, Yi-Shan; Zhuo, Mu-Ning; Li, Ding-Qiang; Guo, Tai-Long

    2013-08-01

    In the Pearl Delta region, urban rivers have been seriously polluted, and the input of non-point source pollution materials, such as chemical oxygen demand (COD), into rivers cannot be neglected. During 2009-2010, the water qualities at eight different catchments in the Fenjiang River of Foshan city were monitored, and the COD loads for eight rivulet sewages were calculated in respect of different rainfall conditions. Interesting results were concluded in our paper. The rainfall and landuse type played important roles in the COD loading, with greater influence of rainfall than landuse type. Consequently, a COD loading formula was constructed that was defined as a function of runoff and landuse type that were derived SCS model and land use map. Loading of COD could be evaluated and predicted with the constructed formula. The mean simulation accuracy for single rainfall event was 75.51%. Long-term simulation accuracy was better than that of single rainfall. In 2009, the estimated COD loading and its loading intensity were 8 053 t and 339 kg x (hm2 x a)(-1), and the industrial land was regarded as the main source of COD pollution area. The severe non-point source pollution such as COD in Fenjiang River must be paid more attention in the future.

  9. Increased Age, but Not Parity Predisposes to Higher Bacteriuria Burdens Due to Streptococcus Urinary Tract Infection and Influences Bladder Cytokine Responses, Which Develop Independent of Tissue Bacterial Loads.

    Science.gov (United States)

    Sullivan, Matthew J; Carey, Alison J; Leclercq, Sophie Y; Tan, Chee K; Ulett, Glen C

    2016-01-01

    Streptococcus agalactiae causes urinary tract infection (UTI) in pregnant adults, non-pregnant adults, immune-compromised individuals and the elderly. The pathogenesis of S. agalactiae UTI in distinct patient populations is poorly understood. In this study, we used murine models of UTI incorporating young mice, aged and dam mice to show that uropathogenic S. agalactiae causes bacteriuria at significantly higher levels in aged mice compared to young mice and this occurs coincident with equivalent levels of bladder tissue colonisation at 24 h post-infection (p.i.). In addition, aged mice exhibited significantly higher bacteriuria burdens at 48 h compared to young mice, confirming a divergent pattern of bacterial colonization in the urinary tract of aged and young mice. Multiparous mice, in contrast, exhibited significantly lower urinary titres of S. agalactiae compared to age-matched nulliparous mice suggesting that parity enhances the ability of the host to control S. agalactiae bacteriuria. Additionally, we show that both age and parity alter the expression levels of several key regulatory and pro-inflammatory cytokines, which are known to be important the immune response to UTI, including Interleukin (IL)-1β, IL-12(p40), and Monocyte Chemoattractant Protein-1 (MCP-1). Finally, we demonstrate that other cytokines, including IL-17 are induced significantly in the S. agalactiae-infected bladder regardless of age and parity status. Collectively, these findings show that the host environment plays an important role in influencing the severity of S. agalactiae UTI; infection dynamics, particularly in the context of bacteriuria, depend on age and parity, which also affect the nature of innate immune responses to infection.

  10. Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load EPF-ANRS CO1).

    Science.gov (United States)

    Tubiana, Roland; Le Chenadec, Jerome; Rouzioux, Christine; Mandelbrot, Laurent; Hamrene, Karima; Dollfus, Catherine; Faye, Albert; Delaugerre, Constance; Blanche, Stephane; Warszawski, Josiane

    2010-02-15

    The rate of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) type 1 is as low as 0.5% in non-breast-feeding mothers who delivered at term while receiving antiretroviral therapy with a plasma viral load <500 copies/mL. This situation accounted for 20% of the infected children born during the period 1997-2006 in the French Perinatal Cohort. We aimed to identify factors associated with such residual transmission risk. We performed a case-control study nested in the aforementioned subpopulation of the French Perinatal Cohort. Nineteen case patients (transmitters) and 60 control subjects (nontransmitters) were included. Case patients and control subjects did not differ by geographical origin, gestational age at HIV diagnosis, type of antiretroviral therapy received, or elective Cesarean delivery. Case patients were less often receiving treatment at the time that they conceived pregnancy than control subjects (16% vs 45%; P=.017). A lower proportion of case patients had a viral load <500 copies/mL, compared with control subjects, at 14 weeks (0% vs 38.1%; P=.02), 28 weeks (7.7% vs 62.1%; P=.005), and 32 weeks: (21.4% vs 71.1%; P=.004). The difference remained significant when we restricted analysis to the 10 of 16 intrapartum transmission cases. In a multivariate analysis at 30+/-4 weeks adjusted for viral load, CD4(+) T cell count, and time at antiretroviral therapy initiation, viral load was the only factor independently associated with MTCT of HIV (adjusted odds ratio, 23.2; 95% confidence interval, 3.5-553; P<.001). Early and sustained control of viral load is associated with a decreasing residual risk of MTCT of HIV-1. Guidelines should take into account not only CD4(+) T cell count and risk of preterm delivery, but also baseline HIV-1 load for deciding when to start antiretroviral therapy during pregnancy.

  11. Institutional Change in a Higher Education Environment: Factors in the Adoption and Sustainability of Information Technology Project Management Best Practices

    Science.gov (United States)

    LeTourneau, John

    2012-01-01

    The public higher education economic and competitive environments make it crucial that organizations react to the circumstances and make better use of available resources (Duderstadt, 2000; Floyd, 2008; Shulman, 2007; State Higher Education Executive Officers (SHEEO), 2009). Viewing higher education through the perspective of new institutionalism…

  12. Remission of depression following electroconvulsive therapy (ECT) is associated with higher levels of brain-derived neurotrophic factor (BDNF).

    Science.gov (United States)

    Freire, Thiago Fernando Vasconcelos; Fleck, Marcelo Pio de Almeida; da Rocha, Neusa Sica

    2016-03-01

    Research on the association between electroconvulsive therapy (ECT) and increased brain derived neurotrophic factor (BDNF) levels has produced conflicting result. There have been few studies which have evaluated BDNF levels in clinical contexts where there was remission following treatment. The objective of this study was to investigate whether remission of depression following ECT is associated with changes in BDNF levels. Adult inpatients in a psychiatric unit were invited to participate in this naturalistic study. Diagnoses were made using the Mini-International Neuropsychiatric Interview (MINI) and symptoms were evaluated at admission and discharge using the Hamilton Rating Scale for Depression (HDRS-17). Thirty-one patients who received a diagnosis of depression and were subjected to ECT were included retrospectively. Clinical remission was defined as a score of less than eight on the HDRS-17 at discharge. Serum BDNF levels were measured in blood samples collected at admission and discharge with a commercial kit used in accordance with the manufacturer's instructions. Subjects HDRS-17 scores improved following ECT (t = 13.29; p = 0.00). A generalized estimating equation (GEE) model revealed a remission × time interaction with BDNF levels as a dependent variable in a Wald chi-square test [Wald χ(2) = 5.98; p = 0.01]. A post hoc Bonferroni test revealed that non-remitters had lower BDNF levels at admission than remitters (p = 0.03), but there was no difference at discharge (p = 0.16). ECT remitters had higher serum BDNF levels at admission and the level did not vary during treatment. ECT non-remitters had lower serum BDNF levels at admission, but levels increased during treatment and were similar to those of ECT remitters at discharge. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Enhanced antidepressant-like effects of the macromolecule trefoil factor 3 by loading into negatively charged liposomes

    Directory of Open Access Journals (Sweden)

    Qin J

    2014-11-01

    Full Text Available Jing Qin,1 Xu Yang,1–3 Jia Mi,4 Jianxin Wang,1 Jia Hou,1,2 Teng Shen,1 Yongji Li,2 Bin Wang,4 Xuri Li,4 Weili Zhu5 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, 2Department of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, 3Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, 4Binzhou Medical University, Yantai, 5National Institute on Drug Dependence, Peking University, Beijing, People’s Republic of China Abstract: Immunocytes, mainly neutrophils and monocytes, exhibit an intrinsic homing property, enabling them to migrate to sites of injury and inflammation. They can thus act as Trojan horses carrying concealed drug cargoes while migrating across impermeable barriers to sites of disease, especially the blood–brain barrier (BBB. In this study, to target circulating phagocytic cells, we formulated negatively charged nanosize liposomes and loaded trefoil factor 3 (TFF3 into liposomes by the pH-gradient method. According to the optimized formulation (5:1.5 of lipid to cholesterol, 10:1 of lipid to drug, 10 mg/mL of lipid concentration, and 10 mmol/L of phosphate-buffered saline, 44.47% entrapment efficiency was obtained for TFF3 liposomes with 129.6 nm particle size and –36.6 mV zeta potential. Compared with neutrally charged liposomes, the negatively charged liposomes showed a strong binding capacity with monocytes and were effectively carried by monocytes to cross the BBB in vitro. Furthermore, enhanced antidepressant-like effects were found in the tail-suspension and forced-swim tests in mice, as measured by decreased immobility time, as well as increased swimming time and reduced immobility in rats. These results suggested that negatively charged liposomes could improve the behavioral responses of TFF3, and our study opens up a new way for the development of

  14. Orthogonal Higher Order Structure and Confirmatory Factor Analysis of the French Wechsler Adult Intelligence Scale (WAIS-III)

    Science.gov (United States)

    Golay, Philippe; Lecerf, Thierry

    2011-01-01

    According to the most widely accepted Cattell-Horn-Carroll (CHC) model of intelligence measurement, each subtest score of the Wechsler Intelligence Scale for Adults (3rd ed.; WAIS-III) should reflect both 1st- and 2nd-order factors (i.e., 4 or 5 broad abilities and 1 general factor). To disentangle the contribution of each factor, we applied a…

  15. Mechanical loading by fluid shear stress of myotube glycocalyx stimulates growth factor expression and nitric oxide production

    NARCIS (Netherlands)

    Juffer, P.; Bakker, A.D.; Klein-Nulend, J.; Jaspers, R.T.

    2014-01-01

    Skeletal muscle fibers have the ability to increase their size in response to a mechanical overload. Finite element modeling data suggest that mechanically loaded muscles in vivo may experience not only tensile strain but also shear stress. However, whether shear stress affects biological pathways

  16. Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011

    Directory of Open Access Journals (Sweden)

    Maria Vitória Assumpção Mourão

    2014-04-01

    Full Text Available Clinical and laboratory risk factors for death from visceral leishmaniasis (VL are relatively known, but quantitative real-time polymerase chain reaction (qPCR might assess the role of parasite load in determining clinical outcome. The aim of this study was to identify risk factors, including parasite load in peripheral blood, for VL poor outcome among children. This prospective cohort study evaluated children aged ≤ 12 years old with VL diagnosis at three times: pre-treatment (T0, during treatment (T1 and post-treatment (T2. Forty-eight patients were included and 16 (33.3% met the criteria for poor outcome. Age ≤ 12 months [relative risk (RR 3.51; 95% confidence interval (CI 1.89-6.52], tachydyspnoea (RR 3.46; 95% CI 2.19-5.47, bacterial infection (RR 3.08; 95% CI 1.27-7.48, liver enlargement (RR 3.00; 95% CI 1.44-6.23 and low serum albumin (RR 7.00; 95% CI 1.80-27.24 were identified as risk factors. qPCR was positive in all patients at T0 and the parasite DNA was undetectable in 76.1% of them at T1 and in 90.7% at T2. There was no statistical association between parasite load at T0 and poor outcome.

  17. The influence of external environment factors on the activity of higher educational establishments in the Russian Federation

    Directory of Open Access Journals (Sweden)

    Olga Leonidovna Guzakova

    2014-05-01

    Full Text Available The instability of market economy development causes continuous changes in the activity of higher educational establishments. The article deals with the processes, taking place in the system of higher professional education in the Russian Federation in recent decades. On the basis of the analysis of statistical data and normative acts of the Government and Ministry of Education and Science of the Russian Federation, the key global and national trends in higher education are identified: increasing demand for higher education, resulted in its considerable offer (the growth of quantitative indicators is not always accompanied by improvement of higher education quality; reduction in the total number of students due to the demographic situation worsening; transition to a multi-level system of higher education under the Bologna process; change in specialties patterns and directions of training specialists with higher professional education due to the economy structural reforms and labor market needs; aggravation of competition. The tendencies lead to the emergence of demographic, political and economic risks. To reduce negative impact of the external risks to the universities’ activity it is necessary to develop corresponding state educational policy in the sphere of higher education and risk management in universities

  18. Factors Related to the Adoption of IT Emerging Technologies by Research and Non-Research Based Higher Education Institutions

    Science.gov (United States)

    Then, Keri Ann; Amaria, Pesi

    2013-01-01

    This study examined the adoption of information technology (IT) emerging technology by higher education institutions with a focus on non-research and research based institutions categorized by Carnegie Mellon classifications that are members of EDUCAUSE, a higher education non-profit organization, whose mission is the use of IT in higher…

  19. Factors, Issues and Interdependencies in the Incorporation of a Web 2.0 Based Learning Environment in Higher Education

    Science.gov (United States)

    Karvounidis, Theodoros; Chimos, Konstantinos; Bersimis, Sotirios; Douligeris, Christos

    2018-01-01

    This work investigates the effect a Web 2.0 learning environment may have in higher education in adding value to the students' existing competencies. The major issues that this work examines are whether the incorporation of a Web 2.0 environment in higher education has an effect on the students' performance and what are the significant factors…

  20. Key Factors that Influence the Diffusion and Infusion of Information and Communication Technologies in Kenyan Higher Education

    Science.gov (United States)

    Macharia, Jimmy K. N.; Pelser, Theunis G.

    2014-01-01

    Previous studies have shown that in the higher education sector, information and communication technology (ICT) provides the impetus for change from the traditional concepts of teaching and learning, as well as prime motivation behind the change in scholarly and professional activities. This underscores the importance of ICT in higher education in…

  1. Deficientes auditivos e escolaridade: fatores diferenciais que possibilitam o acesso ao ensino superior People with hearing impairments and schooling: differential factors that assure access to higher education

    Directory of Open Access Journals (Sweden)

    Milena Valelongo Manente

    2007-04-01

    students' experiences at the higher education level. The purpose of this study was to uncover differential factors which may facilitate such students' access to higher education and those that hinder their entrance and permanence in university studies. Two questionnaires were applied: Group A - university students and B1 - high school students; B2 - other education levels. For Group A the results showed that the facilitating factors were: previous success in school, family support and helpful teachers. The difficulties they reported were factors which corresponded to the absence of the facilitating factors mentioned: lack of success during school years and no support from teachers. Favorable factors for those enrolled in college or university were the support of classmates and family, as well as close attention from teachers' attention. Hindering factors included lack of attention by teachers and absence of guidance by health professionals. The results obtained with Group B showed that subjects wanted to enroll in higher education, but only a few attempted undergoing entrances examinations (vestibular, due to financial issues, fear of doing poorly on the exams and fear of not being able to keep up with the course load. In Group B2 the intention of going to college is rated lower when compared to Group B1. These subjects believed that the aspects related to schooling (scholastic achievement, teacher support, access to technology are pertinent, and that family support can be helpful, however they recognize their own educational challenges and they understand that lack of teacher support can be a hindrance. As a conclusion, specialized institutions do not seem to be prepared to enroll university students with hearing impairments. Subjects from theB1 and B2 Groups showed that the main impediments they faced were of financial order and because of their previous underachievement in school.

  2. Factors that Enable Women of South Asian and African Descent to Succeed in Leadership Positions in Higher Education

    Science.gov (United States)

    Kamassah, Sharon

    2010-01-01

    This research study focused on the factors that enable women of South Asian and African descent to succeed as leaders in the college system. The findings were derived from online questionnaires and in-depth interviews of 16 racialized women from two Greater Toronto Area (GTA) colleges. Many factors and recommendations were shared. Some of the…

  3. Cognitive Load and Cooperation

    DEFF Research Database (Denmark)

    Døssing, Felix Sebastian; Piovesan, Marco; Wengström, Erik Roland

    2017-01-01

    We study the effect of intuitive and reflective processes on cooperation using cognitive load. Compared with time constraint, which has been used in the previous literature, cognitive load is a more direct way to block reflective processes, and thus a more suitable way to study the link between...... intuition and cooperation. Using a repeated public goods game, we study the effect of different levels of cognitive load on contributions. We show that a higher cognitive load increases the initial level of cooperation. In particular, subjects are significantly less likely to fully free ride under high...... cognitive load....

  4. Epstein-Barr virus: general factors, virus-related diseases and measurement of viral load after transplant

    Directory of Open Access Journals (Sweden)

    Luciana Cristina Fagundes Gequelin

    2011-10-01

    Full Text Available The Epstein-Barr virus is responsible for infectious mononucleosis syndrome and is also closely associated to several types of cancer. The main complication involving Epstein-Barr virus infection, both in recipients of hematopoietic stem cells and solid organs, is post-transplant lymphoproliferative disease. The importance of this disease has increased interest in the development of laboratory tools to improve post-transplant monitoring and to detect the disease before clinical evolution. Viral load analysis for Epstein-Barr virus through real-time polymerase chain reaction is, at present, the best tool to measure viral load. However, there is not a consensus on which sample type is the best for the test and what is its predictive value for therapeutic interventions.

  5. Load-Dependent Emission Factors and Chemical Characteristics of IVOCs from a Medium-Duty Diesel Engine.

    Science.gov (United States)

    Cross, Eben S; Sappok, Alexander G; Wong, Victor W; Kroll, Jesse H

    2015-11-17

    A detailed understanding of the climate and air quality impacts of mobile-source emissions requires the characterization of intermediate-volatility organic compounds (IVOCs), relatively-low-vapor-pressure gas-phase species that may generate secondary organic aerosol with high yields. Due to challenges associated with IVOC detection and quantification, IVOC emissions remain poorly understood at present. Here, we describe measurements of the magnitude and composition of IVOC emissions from a medium-duty diesel engine. Measurements are made on an engine dynamometer and utilize a new mass-spectrometric instrument to characterize the load dependence of the emissions in near-real-time. Results from steady-state engine operation indicate that IVOC emissions are highly dependent on engine power, with highest emissions at engine idle and low-load operation (≤25% maximum rated power) with a chemical composition dominated by saturated hydrocarbon species. Results suggest that unburned fuel components are the dominant IVOCs emitted at low loads. As engine load increases, IVOC emissions decline rapidly and become increasingly characterized by unsaturated hydrocarbons and oxygenated organics, newly formed from incomplete combustion processes at elevated engine temperatures and pressures. Engine transients, including a cold-start ignition and engine acceleration, show IVOC emission profiles that are different in amount or composition compared to steady-state combustion, underscoring the utility of characterizing IVOC emissions with high time resolution across realistic engine operating conditions. We find possible evidence for IVOC losses on unheated dilution and sampling surfaces, which need to be carefully accounted for in IVOC emission studies.

  6. Impact of Bulldozer's Engine Load Factor on Fuel Consumption, CO2 Emission and Cost

    OpenAIRE

    V. Kecojevic; D. Komljenovic

    2011-01-01

    Problem statement: Bulldozers consume a large amount of diesel fuel and consequently produce a significant quantity of CO2. Environmental and economic cost issues related to fuel consumption and CO2 emission represent a substantial challenge to the mining industry. Approach: Impact of engine load conditions on fuel consumption and the subsequent CO2 emission and cost was analyzed for Caterpillar bulldozers. Results were compared with the data on bulldozers' fuel consu...

  7. Gender Segregation in the Process of College Student Job Seeking: A Survey of Higher Education as a Prelabor Market Factor

    Science.gov (United States)

    Xin, Tong; Yihui, Su

    2010-01-01

    This article uses information from a 2009 survey of the employment circumstances of female college students from Beijing's higher education institutions to analyze the differences among college students in the process of job seeking. Such divisions are manifested in terms of gender, household registration, human resources, specializations, and…

  8. An Empirical Study of Factors Affecting Mobile Wireless Technology Adoption for Promoting Interactive Lectures in Higher Education

    Science.gov (United States)

    Gan, Chin Lay; Balakrishnan, Vimala

    2016-01-01

    Use of mobile technology is widespread, particularly among the younger generation. There is a huge potential for utilizing such technology in lecture classes with large numbers of students, serving as an interaction tool between the students and lecturers. The challenge is to identify significant adoption factors to ensure effective adoption of…

  9. Mixture simultaneous factor analysis for capturing differences in latent variables between higher level units of multilevel data

    NARCIS (Netherlands)

    De Roover, K.; Vermunt, J.K.; Timmerman, Marieke E.; Ceulemans, Eva

    2017-01-01

    Given multivariate data, many research questions pertain to the covariance structure: whether and how the variables (for example, personality measures) covary. Exploratory factor analysis (EFA) is often used to look for latent variables that may explain the covariances among variables; for example,

  10. The Influence of PISA Scores, Schooling and Social Factors on Pathways to and within Higher Education in Canada

    Science.gov (United States)

    Murdoch, Jake; Kamanzi, Pierre Canisius; Doray, Pierre

    2011-01-01

    In this article, we use data from the Canadian Youth in Transition Survey (YITS). This survey has followed longitudinally the Canadian Programme for International Student Assessment (PISA) students originally surveyed in 2000. The aim of this article is to look to what extent social factors (e.g. gender, parental education and socio-economic…

  11. Policies for higher Education in the realm of Venezuela’s Revolutionary Bolivarian Project: historic and conceptual factors

    Directory of Open Access Journals (Sweden)

    Maria Lucia Frizon Rizzotto

    2010-10-01

    tionary Project, as well as the reasons that led to the creation of the Universidade Bolivariana da Venezuela and of the Missão Sucre, the main higher education policy of the Chavez government. The research focuses on the first Chavez administration, particularly the period from 2003- 2006. It sought to show how the educational process in that country is related with the implementation of the Bolivar Project. The study also analyzes the conception of education subjacent to the higher education policies. The article concludes that the appropriation of liberal principles in the educational process, given the contradictions and polarization experienced by Venezuelan society, cannot make impede achievement of social transformation underway in that country.

  12. Interleaved segment correction achieves higher improvement factors in using genetic algorithm to optimize light focusing through scattering media

    Science.gov (United States)

    Li, Runze; Peng, Tong; Liang, Yansheng; Yang, Yanlong; Yao, Baoli; Yu, Xianghua; Min, Junwei; Lei, Ming; Yan, Shaohui; Zhang, Chunmin; Ye, Tong

    2017-10-01

    Focusing and imaging through scattering media has been proved possible with high resolution wavefront shaping. A completely scrambled scattering field can be corrected by applying a correction phase mask on a phase only spatial light modulator (SLM) and thereby the focusing quality can be improved. The correction phase is often found by global searching algorithms, among which Genetic Algorithm (GA) stands out for its parallel optimization process and high performance in noisy environment. However, the convergence of GA slows down gradually with the progression of optimization, causing the improvement factor of optimization to reach a plateau eventually. In this report, we propose an interleaved segment correction (ISC) method that can significantly boost the improvement factor with the same number of iterations comparing with the conventional all segment correction method. In the ISC method, all the phase segments are divided into a number of interleaved groups; GA optimization procedures are performed individually and sequentially among each group of segments. The final correction phase mask is formed by applying correction phases of all interleaved groups together on the SLM. The ISC method has been proved significantly useful in practice because of its ability to achieve better improvement factors when noise is present in the system. We have also demonstrated that the imaging quality is improved as better correction phases are found and applied on the SLM. Additionally, the ISC method lowers the demand of dynamic ranges of detection devices. The proposed method holds potential in applications, such as high-resolution imaging in deep tissue.

  13. Three Dimensional Parametric Analyses of Stress Concentration Factor and Its Mitigation in Isotropic and Orthotropic Plate with Central Circular Hole Under Axial In-Plane Loading

    Science.gov (United States)

    Nagpal, Shubhrata; Jain, Nitin Kumar; Sanyal, Shubhashis

    2016-01-01

    The problem of finding the stress concentration factor of a loaded rectangular plate has offered considerably analytical difficulty. The present work focused on understanding of behavior of isotropic and orthotropic plate subjected to static in-plane loading using finite element method. The complete plate model configuration has been analyzed using finite element method based software ANSYS. In the present work two parameters: thickness to width of plate (T/A) and diameter of hole to width of plate (D/A) have been varied for analysis of stress concentration factor (SCF) and its mitigation. Plates of five different materials have been considered for complete analysis to find out the sensitivity of stress concentration factor. The D/A ratio varied from 0.1 to 0.7 for analysis of SCF and varied from 0.1 to 0.5 for analyzing the mitigation of SCF. 0.01, 0.05 and 0.1 are considered as T/A ratio for all the cases. The results are presented in graphical form and discussed. The mitigation in SCF reported is very encouraging. The SCF is more sensitive to D/A ratio as compared to T/A.

  14. Prognostic factors for specific lower extremity and spinal musculoskeletal injuries identified through medical screening and training load monitoring in professional football (soccer): a systematic review

    Science.gov (United States)

    Sergeant, Jamie C; Parkes, Matthew J; Callaghan, Michael J

    2017-01-01

    Background Medical screening and load monitoring procedures are commonly used in professional football to assess factors perceived to be associated with injury. Objectives To identify prognostic factors (PFs) and models for lower extremity and spinal musculoskeletal injuries in professional/elite football players from medical screening and training load monitoring processes. Methods The MEDLINE, AMED, EMBASE, CINAHL Plus, SPORTDiscus and PubMed electronic bibliographic databases were searched (from inception to January 2017). Prospective and retrospective cohort studies of lower extremity and spinal musculoskeletal injury incidence in professional/elite football players aged between 16 and 40 years were included. The Quality in Prognostic Studies appraisal tool and the modified Grading of Recommendations Assessment, Development and Evaluation synthesis approach was used to assess the quality of the evidence. Results Fourteen studies were included. 16 specific lower extremity injury outcomes were identified. No spinal injury outcomes were identified. Meta-analysis was not possible due to heterogeneity and study quality. All evidence related to PFs and specific lower extremity injury outcomes was of very low to low quality. On the few occasions where multiple studies could be used to compare PFs and outcomes, only two factors demonstrated consensus. A history of previous hamstring injuries (HSI) and increasing age may be prognostic for future HSI in male players. Conclusions The assumed ability of medical screening tests to predict specific musculoskeletal injuries is not supported by the current evidence. Screening procedures should currently be considered as benchmarks of function or performance only. The prognostic value of load monitoring modalities is unknown. PMID:29177074

  15. An exploratory examination of the relationship between motivational factors and the degree to which the higher education faculty integrate computer-mediated communication (CMC) tools into their courses

    Science.gov (United States)

    Murage, Francis Ndwiga

    The stated research problem of this study was to examine the relationship between motivational factors and the degree to which the higher education faculty integrate CMC tools into their courses. The study population and sample involved higher education faculty teaching in science departments at one public university and three public colleges in the state of West Virginia (N = 153). A Likert-type rating scale survey was used to collect data based on the research questions. Two parts of the survey were adopted from previous studies while the other two were self-constructed. Research questions and hypothesis were analyzed using both descriptive and inferential analyses. The study results established a positive relationship between motivational factors and the degree the higher education faculty integrate CMC tools in their courses. The results in addition established that faculty are highly motivated to integrate CMC tools by intrinsic factors, moderately motivated by environmental factors and least motivated by extrinsic factors. The results also established that the most integrated CMC tools were those that support asynchronous methods of communication while the least integrated were those that support synchronous methods of communication. A major conclusion made was that members of higher education faculty are more likely to be motivated to integrate CMC tools into their courses by intrinsic factors rather than extrinsic or environmental factors. It was further concluded that intrinsic factors that supported and enhanced student learning as well as those that were altruistic in nature significantly influenced the degree of CMC integration. The study finally concluded that to larger extent, there is a relationship between motivational factors and the degree to which the higher education faculty integrate CMC tools in their courses. A major implication of this study was that institutions that wish to promote integration of CMC technologies should provide as much

  16. The Impact of Economic, Political, and Social Factors on Recent Overt Black/White Racial Conflict in Higher Education in the United States.

    Science.gov (United States)

    Jones, Evonne Parker

    1991-01-01

    Addresses the following: (1) what recent literature reveals about overt racial conflict in higher education between whites and African Americans; (2) how different factors influence this conflict; (3) an extensive listing of racism incidents; (4) rising economic anxiety and the nation's political climate; and (5) suggestions for alleviating the…

  17. The Analytic Hierarchy Process of the Decision-Making Factors of African Students in Obtaining Higher Education in the United Arab Emirates

    Science.gov (United States)

    Ahmad, Syed Zamberi; Hussain, Matloub

    2017-01-01

    The mobility of African students beyond national territories has become common worldwide. However, the underlying reasons motivating students to leave their countries of origin in pursuit of higher education in other developing nations and why these factors are important have not been fully explored. This study attempts to explore why and how…

  18. Critical Success Factors to Improve Perception of Information Technology Careers: A Specific Case in a Mexican Higher Education Institution

    Directory of Open Access Journals (Sweden)

    Alejandra Aldrette-Malacara

    2013-06-01

    Full Text Available It is a fact that fashion plays an important role to select a career, new options of careers from engineering are preferred by students instead of traditional options; for example, Mechatronics, Aeronautics, Automotive specializations, Bionics, Biomedical and others are so popular. Every day, new necessities are required in the world and it is necessary to find the way to solve them, for that reason these new majors are good options to students, however traditional areas are important too. Information Technology is not the exception because every enterprise, school, association and organization needs computers with systems that help to solve specific situations or to manage resources. In Mexico, Information Technology careers are been affected for low enrollment of students, of course private universities have suffered more this situation than public schools [1]. In this research work are shown the most important factors that have a real incidence to choose an Information Technology career. The methodology consisted in the design of a survey using seven points Likert´s scale where potential students could express more about their expectative, preferences and required abilities to study these majors. The mentioned survey had three versions and each one was validated through Cronbach’s Alpha. Data collected were analyzed using statistical software SPSS to obtain the critical success factors.

  19. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane eqrthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years. 23 refs., 9 tabs

  20. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1986-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane earthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years

  1. Lateral loadings on snubber assemblies

    International Nuclear Information System (INIS)

    Raphael, L.S.

    1981-01-01

    This paper examines the installation of snubber assemblies in power plants with respect to transverse or lateral loads as well as axial loads. Evaluation of the effects of low level, lateral loads was performed by analytical means. At higher loadings, the snubber assembly could no longer be treated as a column; therefore, the effects of lateral loadings was determined by test. The test consisted of applying both lateral and axial loads simultaneously. Results of both the analysis and the test showed that the application of lateral loads had a considerable effect on the snubber assemblies

  2. Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-β1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Tan, Eng-lai; Selvaratnam, G; Kananathan, R; Sam, Choon-kook

    2006-01-01

    Nasopharyngeal carcinoma (NPC) is a common epithelial neoplasm among the Chinese populations in Southern China and South East Asia. Epstein-Barr virus (EBV) is known to be an important etiologic agent of NPC and the viral gene products are frequently detected in NPC tissues along with elevated antibody titres to the viral proteins (VCA and EA) in a majority of patients. Elevated plasma EBV DNA load is regarded as an important marker for the presence of the disease and for the monitoring of disease progression. However, other serum/plasma parameters such as the levels of certain interleukins and growth factors have also been implicated in NPC. The objectives of the present study are, 1) to investigate the correlations between plasma EBV DNA load and the levels of interleukin (IL)-6, IL-10, TGF-β1 and SCF (steel factor) and 2) to relate these parameters to the stages of NPC and the effect of treatment. A total of 78 untreated NPC patients were enrolled in this study. Of these, 51 were followed-up after treatment. The remaining patients had irregular or were lost to follow-up. Plasma EBV DNA was quantified using real-time quantitative PCR. The levels of plasma interleukins and growth factors were quantified using ELISA. A significant decrease in EBV DNA load was detected in plasma of untreated NPC patients (1669 ± 637 copies/mL; n = 51) following treatment (57 ± 37 copies/mL, p < 0.05); n = 51). Plasma EBV DNA load was shown to be a good prognosticator for disease progression and clinical outcome in five of the follow-up patients. A significant difference in IL-6 levels was noted between the untreated patients (164 ± 37 pg/mL; n = 51) and following treatment (58 ± 16 pg/mL, p < 0.05; n = 51). Positive correlations between EBV DNA load and IL-10 (r(49) = 0.535, p < 0.01), between IL6 and IL-10 (r(49) = 0.474, p < 0.01) and between TGF and SCF (r(49) = 0.464, p < 0.01) were observed in patients following treatment. None of the parameters tested including Ig

  3. Understanding the role of organizational factors in shaping the research careers of women academics in higher education

    Directory of Open Access Journals (Sweden)

    Georgeta Ion

    2014-07-01

    Full Text Available This paper represents an attempt to make a theoretical contribution to its knowledge base through an analysis of the group factors which contribute to the success of women academics engaged in research within the area of social sciences. The data were obtained through a series of in-depth interviews carried out at public universities in Catalonia, with women academics –all of whom were the heads of research groups recognized by the Generalitat [Regional Government] of Catalonia. The findings indicate that research groups provide a supportive and effective environment for female researchers enabling them to develop their academic careers, as measured by such key performance indicators as the number of publications and successful applications for research funding.

  4. Separable projection integrals for higher-order correlators of the cosmic microwave sky: Acceleration by factors exceeding 100

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, J.P., E-mail: jb914@cam.ac.uk [Department of Applied Mathematics and Theoretical Physics, University of Cambridge (United Kingdom); Pennycook, S.J. [Intel Corporation (United Kingdom); Fergusson, J.R.; Jäykkä, J.; Shellard, E.P.S. [Department of Applied Mathematics and Theoretical Physics, University of Cambridge (United Kingdom)

    2016-04-01

    We present a case study describing efforts to optimise and modernise “Modal”, the simulation and analysis pipeline used by the Planck satellite experiment for constraining general non-Gaussian models of the early universe via the bispectrum (or three-point correlator) of the cosmic microwave background radiation. We focus on one particular element of the code: the projection of bispectra from the end of inflation to the spherical shell at decoupling, which defines the CMB we observe today. This code involves a three-dimensional inner product between two functions, one of which requires an integral, on a non-rectangular domain containing a sparse grid. We show that by employing separable methods this calculation can be reduced to a one-dimensional summation plus two integrations, reducing the overall dimensionality from four to three. The introduction of separable functions also solves the issue of the non-rectangular sparse grid. This separable method can become unstable in certain scenarios and so the slower non-separable integral must be calculated instead. We present a discussion of the optimisation of both approaches. We demonstrate significant speed-ups of ≈100×, arising from a combination of algorithmic improvements and architecture-aware optimisations targeted at improving thread and vectorisation behaviour. The resulting MPI/OpenMP hybrid code is capable of executing on clusters containing processors and/or coprocessors, with strong-scaling efficiency of 98.6% on up to 16 nodes. We find that a single coprocessor outperforms two processor sockets by a factor of 1.3× and that running the same code across a combination of both microarchitectures improves performance-per-node by a factor of 3.38×. By making bispectrum calculations competitive with those for the power spectrum (or two-point correlator) we are now able to consider joint analysis for cosmological science exploitation of new data.

  5. Three Dimensional Parametric Analyses on Effect of Fibre Orientation for Stress Concentration Factor in Fibrous Composite Cantilever Plate with Central Circular Hole under Transverse Loading

    Directory of Open Access Journals (Sweden)

    Nitin Jain

    2012-10-01

    Full Text Available Normal 0 false false false EN-IN X-NONE X-NONE ABSTRACT: A number of analytical and numerical techniques are available for the two dimensional study of stress concentration around the hole(s in isotropic and composite plates subjected to in-plane or transverse loading conditions. The information on the techniques for three dimensional analyses of stress concentration factor (SCF around the hole in isotropic and composite plates subjected to transverse loading conditions is, however, limited. The present work emphasizes on the effect of fibre orientation (q on the stress concentration factor in fibrous composite plates with central circular hole under transverse static loading condition. The work is carried out for cantilever fibrous composite plates. The effects of thickness -to- width (T/A and diameter-to-width (D/A ratios upon SCF at different fibre orientation are studied. Plates of four different composite materials were considered for hole analysis in order to determine the sensitivity of SCF with elastic constants. Deflections in transverse direction were calculated and analysed. All results are presented in graphical form and discussed. The finite element formulation and its analysis were carried out using ANSYS package.ABSTRAK: Terdapat pelbagai teknik analitikal dan numerical untuk kajian tumpuan tegasan dua dimensi di sekeliling lubang-lubang dalam komposit isotropik dan plat pada satah atau keadaan bebanan melintang. Bagaimanapun, maklumat mengenai kaedah analisis tiga dimensi untuk faktor ketumpatan tegasan (SCF sekitar lubang dalam komposit isotropik dan plat pada keadaan bebanan melintang adalah terhad. Kertas ini menekankan kesan orientasi gentian (q pada faktor tumpuan tegasan dalam komposit plat bergentian dengan lubang berpusat di bawah keadaan bebanan melintang. Kajian ini dilkukan untuk cantilever plat komposit bergentian. Kesan ketebalan terhadap kelebaran plat (T/A dan diameter terhadap kelebaran komposit (D/A dengan SCF

  6. Determinación IN-SITU del factor de potencia y la eficiencia de motores asincrónicos a cargas parciales; Induction motor power factor and efficiency IN-SITU determination under partial loads.

    Directory of Open Access Journals (Sweden)

    Percy Rafael Viego Felipe

    2015-04-01

    Full Text Available Los motores asincrónicos trifásicos no siempre operan a plena carga y por lo tanto, el factor de potencia y la eficiencia se ven afectados. Determinar estos valores a diferentes cargas, es la base para programas ahorro en la industria y los servicios. En este trabajo se presentan procedimientos para la estimación del factor de potencia y la eficiencia a cargas parciales, con una precisión acorde a los propósitos ingenieriles, baja invasividad y sin implicar para el usuario complejidades de equipamiento o de adquisición y procesamiento de datos. Se ofrecen distintas variantes para la estimación del factor de potencia y la eficiencia, según los datos con que se cuente. Se comparan los resultados de los métodos propuestos con la información de catálogos comerciales. Se realiza un análisis con motores de distinta potencia y velocidad, que demuestra que se logra buena precisión para los propósitos señalados. Three phase induction motors are rarely operating at full load and, in consequence, power factor and efficiency are affected. Determining these values for different partial loads is needed for energy saving programs in industrial and service enterprises. In this work, procedures are given for power factor and efficiency estimation at different loads. These procedures are low or not-invasive, have a good precision for engineering purposes, and do not require neither complex equipment nor complicated acquisition and processing data systems Different ways for estimating the before mentioned parameters, depending on the known data, are given. The results of the proposed procedures are compared with those of manufacturer catalogs. A comparative analysis considering motors of different output power and speed is done, and it shows that the results are enough accurate for the established purposes.

  7. Investigation of R-Factor for steel moment frame combined with cold-formed steel structures under different load patterns using pushover analysis

    Directory of Open Access Journals (Sweden)

    Siavash Sadeghi

    2017-08-01

    Full Text Available The use of Lightweight Steel Frames (LSF has grown considerably in recent years all over the world due to its unique advantages such as being cost-effective and light-weight, easy and quick installment. Another application is to use them in order to increase the number of new floors on the existing buildings. But since the behavior of the combined structure is not clear, there is no possibility of increasing new floors with Lightweight Steel Frames. Therefore, through selecting and modeling three buildings of three, five and seven floors with steel moment frames in SAP2000 software and adding one or two new floors using Lightweight Steel Frames (LSF and conducting a non-linear static analysis with three different lateral load pattern, we dealt with the seismic behavior and determined the behavior coefficient of each of the combined structures. The results indicated that the use of cold-formed structures in order to add story do not have a significant impact on R-factor. In addition, R-factor depends on the type of the side loading pattern.

  8. Load and resistance factor design calibration to determine a resistance factor for the modification of the Kansas Department of Transportation-Engineering News Record formula.

    Science.gov (United States)

    2014-02-01

    This report contains the results of a study describing the development of resistance factors for use : with the Kansas Department of Transportation (KDOT) Engineering News Record (ENR) formula for driven : piles. KDOT has verified driven pile resista...

  9. Mixed-mode stress intensity factors for kink cracks with finite kink length loaded in tension and bending: application to dentin and enamel.

    Science.gov (United States)

    Bechtle, Sabine; Fett, Theo; Rizzi, Gabriele; Habelitz, Stefan; Schneider, Gerold A

    2010-05-01

    Fracture toughness resistance curves describe a material's resistance against crack propagation. These curves are often used to characterize biomaterials like bone, nacre or dentin as these materials commonly exhibit a pronounced increase in fracture toughness with crack extension due to co-acting mechanisms such as crack bridging, crack deflection and microcracking. The knowledge of appropriate stress intensity factors which depend on the sample and crack geometry is essential for determining these curves. For the dental biomaterials enamel and dentin it was observed that, under bending and tensile loading, crack propagation occurs under certain constant angles to the initial notch direction during testing procedures used for fracture resistance curve determination. For this special crack geometry (a kink crack of finite length in a finite body) appropriate geometric function solutions are missing. Hence, we present in this study new mixed-mode stress intensity factors for kink cracks with finite kink length within samples of finite dimensions for two loading cases (tension and bending) which were derived from a combination of mixed-mode stress intensity factors of kink cracks with infinitely small kinks and of slant cracks. These results were further applied to determine the fracture resistance curves of enamel and dentin by testing single edge notched bending (SENB) specimens. It was found that kink cracks with finite kink length exhibit identical stress fields to slant cracks as soon as the kink length exceeds 0.15 times the initial straight crack or notch length. The use of stress intensity factor solutions for infinitely small kink cracks for the determination of dentin fracture resistance curves (as was done by other researchers) leads to an overestimation of dentin's fracture resistance of up to 30%. Copyright 2010 Elsevier Ltd. All rights reserved.

  10. Higher-order cognitive factors affect subjective but not proprioceptive aspects of self-representation in the rubber hand illusion.

    Science.gov (United States)

    Dempsey-Jones, Harriet; Kritikos, Ada

    2014-05-01

    In the current study we look at whether subjective and proprioceptive aspects of selfrepresentation are separable components subserved by distinct systems of multisensory integration. We used the rubber hand illusion (RHI) to draw the location of the 'self' away from the body, towards extracorporeal space (Out Condition), thereby violating top-down information about the body location. This was compared with the traditional RHI which drew position of the 'self' towards the body (In Condition). We were successfully able to draw proprioceptive position of the limbs in and out from the body suggesting body perception is a purely bottom-up process, resistant to top-down effects. Conversely, we found subjective self-representation was altered by the violation of top-down body information - as the strong association of subjective and proprioceptive factors found in the In Condition became non-significant in the Out Condition. Interestingly, we also found evidence that subjective embodiment can modulate tactile perception. Copyright © 2014. Published by Elsevier Inc.

  11. Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions

    Directory of Open Access Journals (Sweden)

    Yu-Ping Hung

    2017-06-01

    Full Text Available Deep ocean water (DOW has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM and its protective effects on the liver. In this study, the antiliver fibrosis effects and mechanisms of ultrapure water-cultured CM (UCM, DOW-cultured CM (DCM, synthetic water-cultured CM, DOW, cordycepin, and adenosine were compared in the liver fibrosis mice induced by intraperitoneal injections of thioacetamide (TAA. The results indicated that DCM exhibited superior performance in reducing liver collagen accumulation, mitigating liver injuries, inhibiting proinflammatory factors and fibrosis-related factor (TGF-β1, Smad2/3, α-SMA, COL1A1 expression compared with UCM. DOW, cordycepin, and adenosine also performed antiliver fibrosis effect. Therefore, because DCM is rich in DOW and functional components, it can achieve anti-liver fibrosis effects through multiple pathways. These ameliorative effects are considerably superior to those of UCM.

  12. Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions.

    Science.gov (United States)

    Hung, Yu-Ping; Lee, Chun-Lin

    2017-06-08

    Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver. In this study, the antiliver fibrosis effects and mechanisms of ultrapure water-cultured CM (UCM), DOW-cultured CM (DCM), synthetic water-cultured CM, DOW, cordycepin, and adenosine were compared in the liver fibrosis mice induced by intraperitoneal injections of thioacetamide (TAA). The results indicated that DCM exhibited superior performance in reducing liver collagen accumulation, mitigating liver injuries, inhibiting proinflammatory factors and fibrosis-related factor (TGF-β1, Smad2/3, α-SMA, COL1A1) expression compared with UCM. DOW, cordycepin, and adenosine also performed antiliver fibrosis effect. Therefore, because DCM is rich in DOW and functional components, it can achieve anti-liver fibrosis effects through multiple pathways. These ameliorative effects are considerably superior to those of UCM.

  13. Monte Carlo Method to Study Properties of Acceleration Factor Estimation Based on the Test Results with Varying Load

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    N. D. Tiannikova

    2014-01-01

    Full Text Available G.D. Kartashov has developed a technique to determine the rapid testing results scaling functions to the normal mode. Its feature is preliminary tests of products of one sample including tests using the alternating modes. Standard procedure of preliminary tests (researches is as follows: n groups of products with m elements in each start being tested in normal mode and, after a failure of one of products in the group, the remained products are tested in accelerated mode. In addition to tests in alternating mode, tests in constantly normal mode are conducted as well. The acceleration factor of rapid tests for this type of products, identical to any lots is determined using such testing results of products from the same lot. A drawback of this technique is that tests are to be conducted in alternating mode till the failure of all products. That is not always is possible. To avoid this shortcoming, the Renyi criterion is offered. It allows us to determine scaling functions using the right-censored data thus giving the opportunity to stop testing prior to all failures of products.In this work a statistical modeling of the acceleration factor estimation owing to Renyi statistics minimization is implemented by the Monte-Carlo method. Results of modeling show that the acceleration factor estimation obtained through Renyi statistics minimization is conceivable for rather large n . But for small sample volumes some systematic bias of acceleration factor estimation, which decreases with growth n is observed for both distributions (exponential and Veybull's distributions. Therefore the paper also presents calculation results of correction factors for a case of exponential distribution and Veybull's distribution.

  14. Independent predictive factors for significant liver histological changes in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal alanine aminotransferase level

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    LI Qiang

    2016-07-01

    Full Text Available Objective To investigate the independent predictive factors for significant liver histological changes (SLHCs in patients with HBeAg-positive high-viral-load chronic hepatitis B virus (HBV infection and a normal alanine aminotransferase (ALT level. MethodsA retrospective analysis was performed on the clinical data of 116 previously untreated patients with HBeAg-positive high-viral-load (HBV DNA≥105 copies/ml chronic HBV infection and a normal ALT level (<50 U/L who were hospitalized in Shanghai Public Health Clinical Center Affiliated to Fudan University from June 2013 to August 2015. The definition of SLHCs was inflammation ≥G2 and/or fibrosis≥S2. The t-test or Mann-Whitney U rank sum test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Univariate and multivariate regression analyses were used to determine independent predictive factors for SLHCs. ResultsOf all the 116 patients, 47(40.5% had SLHCs. The multivariate analysis showed that age (OR=2.828, P<0.05, ALT (OR=1.011, P<0.05, and gamma-glutamyl transpeptidase (GGT (OR=1.089, P<0.05 were independent predictors for SLHCs in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level. The patients aged ≤30 years had a significantly lower incidence rate of SLHCs than those aged>30 years (21.6% vs 49.4%, χ2=6.42, P=0.015, the patients with ALT ≤30 U/L had a significantly lower incidence rate of SLHCs than those with 30 U/L<ALT≤50 U/L (17.6% vs 50.0%, χ2=19.86, P<0.001, and the patients with GGT≤40 U/L had a significantly lower incidence rate of SLHCs than those with GGT>40 U/L (28.8% vs 66.7%, χ2=28.63, P<0.001. ConclusionIn patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level, those with an age of>30 years, ALT>30 U/L, and GGT>40 U/L tend to develop SLHCs and need liver biopsy.

  15. Cumulative socioeconomic status risk, allostatic load, and adjustment: a prospective latent profile analysis with contextual and genetic protective factors.

    Science.gov (United States)

    Brody, Gene H; Yu, Tianyi; Chen, Yi-fu; Kogan, Steven M; Evans, Gary W; Beach, Steven R H; Windle, Michael; Simons, Ronald L; Gerrard, Meg; Gibbons, Frederick X; Philibert, Robert A

    2013-05-01

    The health disparities literature has identified a common pattern among middle-aged African Americans that includes high rates of chronic disease along with low rates of psychiatric disorders despite exposure to high levels of cumulative socioeconomic status (SES) risk. The current study was designed to test hypotheses about the developmental precursors to this pattern. Hypotheses were tested with a representative sample of 443 African American youths living in the rural South. Cumulative SES risk and protective processes were assessed at ages 11-13 years; psychological adjustment was assessed at ages 14-18 years; genotyping at the 5-HTTLPR was conducted at age 16 years; and allostatic load (AL) was assessed at age 19 years. A latent profile analysis identified 5 profiles that evinced distinct patterns of SES risk, AL, and psychological adjustment, with 2 relatively large profiles designated as focal profiles: a physical health vulnerability profile characterized by high SES risk/high AL/low adjustment problems, and a resilient profile characterized by high SES risk/low AL/low adjustment problems. The physical health vulnerability profile mirrored the pattern found in the adult health disparities literature. Multinomial logistic regression analyses indicated that carrying an s allele at the 5-HTTLPR and receiving less peer support distinguished the physical health vulnerability profile from the resilient profile. Protective parenting and planful self-regulation distinguished both focal profiles from the other 3 profiles. The results suggest the public health importance of preventive interventions that enhance coping and reduce the effects of stress across childhood and adolescence.

  16. Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut.

    Directory of Open Access Journals (Sweden)

    Vincent Raquin

    2017-12-01

    Full Text Available Dengue virus (DENV causes more human infections than any other mosquito-borne virus. The current lack of antiviral strategies has prompted genome-wide screens for host genes that are required for DENV infectivity. Earlier transcriptomic studies that identified DENV host factors in the primary vector Aedes aegypti used inbred laboratory colonies and/or pools of mosquitoes that erase individual variation. Here, we performed transcriptome sequencing on individual midguts in a field-derived Ae. aegypti population to identify new candidate host factors modulating DENV replication. We analyzed the transcriptomic data using an approach that accounts for individual co-variation between viral RNA load and gene expression. This approach generates a prediction about the agonist or antagonist effect of candidate genes on DENV replication based on the sign of the correlation between gene expression and viral RNA load. Using this method, we identified 39 candidate genes that went undetected by conventional pairwise comparison of gene expression levels between DENV-infected midguts and uninfected controls. Only four candidate genes were detected by both methods, emphasizing their complementarity. We demonstrated the value of our approach by functional validation of a candidate agonist gene encoding a sterol regulatory element-binding protein (SREBP, which was identified by correlation analysis but not by pairwise comparison. We confirmed that SREBP promotes DENV infection in the midgut by RNAi-mediated gene knockdown in vivo. We suggest that our approach for transcriptomic analysis can empower genome-wide screens for potential agonist or antagonist factors by leveraging inter-individual variation in gene expression. More generally, this method is applicable to a wide range of phenotypic traits displaying inter-individual variation.

  17. Identification of the Uncertainties for the Calibration of the Partial Safety Factors for Load in Tidal Turbines

    Directory of Open Access Journals (Sweden)

    Gaizka Zarraonandia Simeón

    2016-03-01

    Full Text Available Tidal energy is nowadays one of the fastest growing types of marine renewable energy. In particular, Horizontal Axis Tidal Turbines (HATTs are the most advanced designs and the most appropriate for standardization. This paper presents a review of actual design criteria focusing on the identification of the uncertainties that technology developers need to address during the design process. Key environmental parameters like turbine inflow conditions or predictions of extreme values are still grey areas due to the lack of site measurements and the uncertainty in metocean model predictions. A comparison of turbulence intensity characterization using different tools and at different points in time shows the uncertainty in the prediction of this parameter. Numerical models of HATTs are still quite uncertain, often dependent on experience of the people running them. In the reliability-based calibration of partial safety factors, the uncertainties need to be reflected on the limit state formulation. This paper analyses the different types of uncertainties present in the limit state equation. These uncertainties are assessed in terms of stochastic variables in the limit state equation. In some cases, advantage can be taken from the experience from offshore wind and oil and gas industries. Tidal turbines have a mixture of the uncertainties present in both industries with regard to partial safety factor calibration.

  18. Effects of higher modes and MDOF on strength reduction factor of elastoplastic structures under far and near-fault ground motions

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    Mohsen Gerami

    2017-06-01

    Full Text Available In seismic codes, the force strength reduction factor is proposed to transform elastic to inelastic strength. The ductility reduction factor, Rμ, plays a key role on R factor if no overstrength is present. The Rμ is determined by SDOF systems. But the higher mode (HM and Multi-Degree-of-Freedom (MDOF effects need to be considered to extract the R factor. These effects are studied by proposing αv-MDOF via at least 1764 Nonlinear dynamic Analysis of 2D-frames. Also a sensitivity study has been performed on Rμ and αv-MDOF. Results obtained from studies conducted on the frames, indicate that HM and MDOF effects have a considerable influence on the base shear. Also the αv-MDOF is typically higher than unity both for ordinary and for near-field earthquakes and it is affected by period, span number and ductility level. These effects are remarkable for near-field motions. Finally, a simplified practical expression is proposed to estimate the αv-MDOF.

  19. Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

    Directory of Open Access Journals (Sweden)

    Ai C

    2017-10-01

    Full Text Available Chengchong Ai, Dandan Sheng, Jun Chen, Jiangyu Cai, Siheng Wang, Jia Jiang, Shiyi Chen Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract: Ultra-high-molecular-weight polyethylene (UHMWPE has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF was loaded on the surface of materials, the loading was performed by silk fibroin (SF coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM and attenuated total reflectance (ATR-Fourier transform infrared (FTIR and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8 assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF

  20. Interaction of Mechanical Load with Growth Hormone (GH) and Insulin-Like Growth Factor I (IGF-I) on Slow-Twitch Skeletal Muscle and Bone

    Science.gov (United States)

    Linderman, Jon K.; Gosselink, Kristin L.; Wang, Tommy J.; Mukku, Venkat R.; Grindeland, Richard E.

    1994-01-01

    Exogenous humoral growth factors, combined with increased mechanical loading, reportedly induce hypertrophy of fast-, but not slow-twitch skeletal muscles, and have little effect in attenuating atrophy of slow-twitch muscle associated with exposure to microgravity in animals with intact neuroendocrine systems. These observations suggest that anabolic adjuvants and muscle tension do not interact to stimulate growth or maintenance of slow-twitch skeletal muscle. The purpose of the present study was to determine whether a chronic increase in mechanical loading (synergistic ablation) or hindlimb unweighting (hindlimb suspension) interact with exogenous GH and IGF-I (Genentech, So San Francisco, CA) in the slow-twitch soleus muscles of female rats (approx. 250 g). Bilateral ablation of the plantaris and gastrocnemius muscles induced 38% and 40% increases in the absolute (mg/pair) and relative (mg/100 g body weight) weights of the soleus, respectively (p less than or = 0.05), in ambulatory rats. GH and IGF-I interacted with chronic loading to increase absolute soleus mass an additional 20% (p less than or = 0.05), and mixed and myofibrillar protein contents an additional 12% and 7%, respectively (NS). In contrast, hindlimb suspension (HLS) resulted in 20% and 18% decreases in the absolute and relative weights of the soleus, respectively (p less than or = 0.05); GH and IGF-I did not spare loss of soleus mass or protein content in HLS rats. HLS decreased tibial plate thickness approx. 11% (p less than or = 0.05), but not weights of the tibia or femus. GH and IGF-I increased tibial plate thickness approx. 30% (p less than or = 0.05), in ambulatory and HLS rats, and increased femur and tibial weights 12% (p less than or = 0.05) and 8% (NS), respectively, in ambulatory rats, but had no effect in HLS rats. Results of the present investigation suggest that GH and IGF-I can stimulate hypertrophy of slow-twitch skeletal muscle when chronically overloaded, but can also stimulate

  1. Ultrasound-targeted stromal cell-derived factor-1-loaded microbubble destruction promotes mesenchymal stem cell homing to kidneys in diabetic nephropathy rats

    Directory of Open Access Journals (Sweden)

    Wu S

    2014-12-01

    Full Text Available Shengzheng Wu,1 Lu Li,1 Gong Wang,1 Weiwei Shen,2 Yali Xu,1 Zheng Liu,1 Zhongxiong Zhuo,1 Hongmei Xia,1 Yunhua Gao,1 Kaibin Tan1 1Department of Ultrasound, 2Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China Abstract: Mesenchymal stem cell (MSC therapy has been considered a promising strategy to cure diabetic nephropathy (DN. However, insufficient MSCs can settle in injured kidneys, which constitute one of the major barriers to the effective implementation of MSC therapy. Stromal cell-derived factor-1 (SDF-1 plays a vital role in MSC migration and involves activation, mobilization, homing, and retention, which are presumably related to the poor homing in DN therapy. Ultrasound-targeted microbubble destruction has become one of the most promising strategies for the targeted delivery of drugs and genes. To improve MSC homing to DN kidneys, we present a strategy to increase SDF-1 via ultrasound-targeted microbubble destruction. In this study, we developed SDF-1-loaded microbubbles (MBSDF-1 via covalent conjugation. The characterization and bioactivity of MBSDF-1 were assessed in vitro. Target release in the targeted kidneys was triggered with diagnostic ultrasound in combination with MBSDF-1. The related bioeffects were also elucidated. Early DN was induced in rats with streptozotocin. Green fluorescent protein-labeled MSCs were transplanted intravenously following the target release of SDF-1 in the kidneys of normal and DN rats. The homing efficacy was assessed by detecting the implanted exogenous MSCs at 24 hours. The in vitro results showed an impressive SDF-1 loading efficacy of 79% and a loading content of 15.8 µg/mL. MBSDF-1 remained bioactive as a chemoattractant. In the in vivo study, SDF-1 was successfully released in the targeted kidneys. The homing efficacy of MSCs to DN kidneys after the target release of SDF-1 was remarkably ameliorated at 24 hours compared with

  2. The role of the demand-duration curve in the evaluation of power station installation policies. Remarks on its effects on stations' utilization, generating capacity, load factor history and consumptions

    International Nuclear Information System (INIS)

    Graziani, G.; Maineri, M.; Zanantoni, C.

    1976-12-01

    The role of the load-duration curve in determining the installation policy for an electric power system, is examined. The effect of the priority order for the allocation of the power stations in the load-diagram is also discussed: in the model used here (program TOTEM) this priority is given as a function of type and age of the station. The significance of the load factor history for a power station as a function of its age is also discussed. It is suggested that such a curve be deduced as a result of strategy calculations made with TOTEM rather than assumping it as input data

  3. FACTORS INFLUENCING STUDENTS UNREST IN INSTITUTIONS OF HIGHER LEARNING AND ITS IMPLICATIONS ON THE ACADEMIC PERFORMANCE OF STUDENTS IN UNIVERSITY OF UYO, AKWA IBOM STATE, NIGERIA

    Directory of Open Access Journals (Sweden)

    Davies K.U

    2016-06-01

    Full Text Available Nigerians have for some time been disturbed by the alarming rate at which students' unrest in Nigerian institutions of higher learning have led to destruction of lives and property and untimely interruption of the planned academic programmes. On the basis of the above exposition, the project examined the concept of students’ unrest, factors that influence students’ unrest and its implication on the academic performance of students. A survey research design was adopted and a fifteen items questionnaire entitled "Factors Influencing Students’ Unrest in Institution of Higher Learning Questionnaire" (FISUIHLQ, was used to collect the data needed for analysis. Percentage, frequency count, and mean model were used to analyze the data collected. Items that fall between 0.50-1.49 mean score were considered Very Low, items that fall between 1.50-2.49 mean score were considered Low, items that fall between 2.50-3.49 mean score were considered Moderate, Items that fall between 3.50-4.49 mean score were considered High, while items that fall between mean scores of 4.50-5.00 were considered Very High. The study, therefore, discovered that breaking of rules and regulations, lack of social amenities and students involvement in cultism were seen as 'high' with mean scores of 2.60, 3.71 and 4.16 respectively, that is, they are serious factors that can influence students unrest in institutions of higher learning. While effective students’ union body and periodic strike by staff of the institution were seen as 'Low' with mean score of 2.21 and 1.96 respectively, that is, they are less serious factors that can influence students’ unrest. Also, it was discovered that disrupts of academic programmes, closure of schools, lecturers not unable to cover syllabus, and brain drain syndrome are the implications of students unrest with mean scores of 3.70,2.84,4.06,2.96 respectively were seen as ‘High’, that is, they are serious implication of students

  4. The influence of biotic and abiotic factors on "1"3"7Cs accumulation in higher fungi after the accident at Chernobyl NPP

    International Nuclear Information System (INIS)

    Zarubina, N.

    2016-01-01

    Levels of soil contamination with "1"3"7Cs, the belonging of fungi to a certain ecological group, the localization depth of the main part of mycelium in soil are the primary factors influencing the value of "1"3"7Cs specific activity in higher fungi after the accident at Chernobyl NPP. It has been found that the value of "1"3"7Cs specific activity in fungi of one species could vary by more than 10 times during a vegetation period. A correlation between the changes of "1"3"7Cs content in fungi during the vegetation period and the amount of precipitates during various periods preceding the collection of samples has not been determined. An assumption has been proposed stating dependence between peculiarities of mycelium growth during the vegetation period and the changes of "1"3"7Cs specific activity in fungi. - Highlights: • Factors influencing on the "1"3"7Cs accumulation by higher fungi have been studied. • "1"3"7Cs specific activity levels in one species fungi could change to up to 10 times during a vegetation season. • A reliable linear dependence of "1"3"7Cs content in fungi on precipitate quantity has not been determined.

  5. Spatial analysis of instream nitrogen loads and factors controlling nitrogen delivery to streams in the southeastern United States using spatially referenced regression on watershed attributes (SPARROW) and regional classification frameworks

    Science.gov (United States)

    Hoos, Anne B.; McMahon, Gerard

    2009-01-01

    Understanding how nitrogen transport across the landscape varies with landscape characteristics is important for developing sound nitrogen management policies. We used a spatially referenced regression analysis (SPARROW) to examine landscape characteristics influencing delivery of nitrogen from sources in a watershed to stream channels. Modelled landscape delivery ratio varies widely (by a factor of 4) among watersheds in the southeastern United States—higher in the western part (Tennessee, Alabama, and Mississippi) than in the eastern part, and the average value for the region is lower compared to other parts of the nation. When we model landscape delivery ratio as a continuous function of local-scale landscape characteristics, we estimate a spatial pattern that varies as a function of soil and climate characteristics but exhibits spatial structure in residuals (observed load minus predicted load). The spatial pattern of modelled landscape delivery ratio and the spatial pattern of residuals coincide spatially with Level III ecoregions and also with hydrologic landscape regions. Subsequent incorporation into the model of these frameworks as regional scale variables improves estimation of landscape delivery ratio, evidenced by reduced spatial bias in residuals, and suggests that cross-scale processes affect nitrogen attenuation on the landscape. The model-fitted coefficient values are logically consistent with the hypothesis that broad-scale classifications of hydrologic response help to explain differential rates of nitrogen attenuation, controlling for local-scale landscape characteristics. Negative model coefficients for hydrologic landscape regions where the primary flow path is shallow ground water suggest that a lower fraction of nitrogen mass will be delivered to streams; this relation is reversed for regions where the primary flow path is overland flow.

  6. Factors Determining the Development of Physical Education in the Higher University Schools of Lithuania in the Context of the Challenges of the 21st Century

    Directory of Open Access Journals (Sweden)

    Povilas Tamošauskas

    2011-04-01

    Full Text Available In the 19 th century the humankind will have to carry out a great job - to give sense to life and learn to behave humanely in a technocratic society. Students of higher schools live in the world where changes dominate and the tempo of the changes increases. Our life in such a world gives rise to stresses of global and local character. The mission of physical education and sport at Universities is to help to humanize the life of the academic youth in the context of physical and psychical harmony. A personality becomes the ideal of modern society only when he or she realizes the potential at a maximum and is physically and psychologically sound. It means that our universities should foresee the strategy of the development of physical education if they want to respond adequately to the challenges of the global world. Research aim is to analyze trends of physical education in the Lithuanian university higher schools and state the factors determining its development. Research object is physical education of students. The article presents university systems of American, European as well as of Asian and African countries. Not enough care or attention is given to the physical education and sport training of students in all educational systems. The Lithuanian higher schools decrease obligatory hours for physical education leaving two hours per week. Sometimes this subject becomes an optional one, completely ignoring the law of physical education and sport. Economic, social, technological and humane factors in the context of physical education are being discussed as well. The strategy of students’ physical education and sport is presented.

  7. Higher B-cell activating factor levels at birth are positively associated with maternal dairy farm exposure and negatively related to allergy development.

    Science.gov (United States)

    Lundell, Anna-Carin; Hesselmar, Bill; Nordström, Inger; Adlerberth, Ingegerd; Wold, Agnes E; Rudin, Anna

    2015-10-01

    A high proportion of circulating immature/naive CD5(+) B cells during early infancy is a risk factor for allergy development. B-cell activating factor (BAFF) is an important cytokine for B-cell maturation. We sought to investigate whether BAFF levels are related to environmental exposures during pregnancy and early childhood and whether BAFF levels are associated with postnatal B-cell maturation and allergic disease. In the FARMFLORA study, including both farming and nonfarming families, we measured BAFF levels in plasma from mothers and their children at birth and at 1, 4, 18, and 36 months of age. Infants' blood samples were also analyzed for B-cell numbers and proportions of CD5(+) and CD27(+) B cells. Allergic disease was clinically evaluated at 18 and 36 months of age. Circulating BAFF levels were maximal at birth, and farmers' children had higher BAFF levels than nonfarmers' children. Higher BAFF levels at birth were positively associated with proportions of CD27(+) memory B cells among farmers' children and inversely related to proportions of CD5(+) immature/naive B cells among nonfarmers' children. Children with allergic disease at 18 months of age had lower cord blood BAFF levels than nonallergic children. At birth, girls had higher BAFF levels and lower proportions of CD5(+) B cells than boys. Farm exposure during pregnancy appears to induce BAFF production in the newborn child, and high neonatal BAFF levels were associated with more accelerated postnatal B-cell maturation, which lend further strength to the role of B cells in the hygiene hypothesis. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  8. Load theory behind the wheel; perceptual and cognitive load effects.

    Science.gov (United States)

    Murphy, Gillian; Greene, Ciara M

    2017-09-01

    Perceptual Load Theory has been proposed as a resolution to the longstanding early versus late selection debate in cognitive psychology. There is much evidence in support of Load Theory but very few applied studies, despite the potential for the model to shed light on everyday attention and distraction. Using a driving simulator, the effect of perceptual and cognitive load on drivers' visual search was assessed. The findings were largely in line with Load Theory, with reduced distractor processing under high perceptual load, but increased distractor processing under high cognitive load. The effect of load on driving behaviour was also analysed, with significant differences in driving behaviour under perceptual and cognitive load. In addition, the effect of perceptual load on drivers' levels of awareness was investigated. High perceptual load significantly increased inattentional blindness and deafness, for stimuli that were both relevant and irrelevant to driving. High perceptual load also increased RTs to hazards. The current study helps to advance Load Theory by illustrating its usefulness outside of traditional paradigms. There are also applied implications for driver safety and roadway design, as the current study suggests that perceptual and cognitive load are important factors in driver attention. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  9. Preadipocyte Factor-1 Levels Are Higher in Women with Hypothalamic Amenorrhea and Are Associated with Bone Mineral Content and Bone Mineral Density through a Mechanism Independent of Leptin

    Science.gov (United States)

    Aronis, Konstantinos N.; Kilim, Holly; Chamberland, John P.; Breggia, Anne; Rosen, Clifford

    2011-01-01

    Context: Preadipocyte factor 1 (pref-1) is increased in anorexia nervosa and is associated negatively with bone mineral density (BMD). No previous studies exist on pref-1 in women with exercise-induced hypothalamic amenorrhea (HA), which similar to anorexia nervosa, is an energy-deficiency state associated with hypoleptinemia. Objective: Our objective was to evaluate whether pref-1 levels are also elevated and associated with low BMD and to assess whether leptin regulates pref-1 levels in women with HA. Design: Study 1 was a double-blinded, placebo-controlled randomized clinical trial of metreleptin administration in women with HA. Study 2 was an open-label study of metreleptin administration in low physiological, supraphysiological, and pharmacological doses in healthy women volunteers. Setting and Patients: At Beth Israel Deaconess Medical Center, 20 women with HA and leptin levels higher than 5 ng/ml and nine healthy control women participated in study 1, and five healthy women participated in study 2. Intervention: For study 1, 20 HA subjects were randomized to receive either 0.08 mg/kg metreleptin (n = 11) or placebo (n = 9). For study 2, five healthy subjects received 0.01, 0.1, and 0.3 mg/kg metreleptin in both fed and fasting conditions for 1 and 3 d, respectively. Main Outcome Measures: Circulating pref-1 and leptin levels were measured. Results: Pref-1 was significantly higher in HA subjects vs. controls (P = 0.035) and negatively associated with BMD (ρ = −0.38; P < 0.01) and bone mineral content (ρ = −0.32; P < 0.05). Metreleptin administration did not alter pref-1 levels in any study reported herein. Conclusions: Pref-1 is higher in HA subjects than controls. Metreleptin administration at low physiological, supraphysiological, and pharmacological doses does not affect pref-1 levels, suggesting that hypoleptinemia is not responsible for higher pref-1 levels and that leptin does not regulate pref-1. PMID:21795455

  10. Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin.

    Science.gov (United States)

    Aronis, Konstantinos N; Kilim, Holly; Chamberland, John P; Breggia, Anne; Rosen, Clifford; Mantzoros, Christos S

    2011-10-01

    Preadipocyte factor 1 (pref-1) is increased in anorexia nervosa and is associated negatively with bone mineral density (BMD). No previous studies exist on pref-1 in women with exercise-induced hypothalamic amenorrhea (HA), which similar to anorexia nervosa, is an energy-deficiency state associated with hypoleptinemia. Our objective was to evaluate whether pref-1 levels are also elevated and associated with low BMD and to assess whether leptin regulates pref-1 levels in women with HA. Study 1 was a double-blinded, placebo-controlled randomized clinical trial of metreleptin administration in women with HA. Study 2 was an open-label study of metreleptin administration in low physiological, supraphysiological, and pharmacological doses in healthy women volunteers. At Beth Israel Deaconess Medical Center, 20 women with HA and leptin levels higher than 5 ng/ml and nine healthy control women participated in study 1, and five healthy women participated in study 2. For study 1, 20 HA subjects were randomized to receive either 0.08 mg/kg metreleptin (n = 11) or placebo (n = 9). For study 2, five healthy subjects received 0.01, 0.1, and 0.3 mg/kg metreleptin in both fed and fasting conditions for 1 and 3 d, respectively. Circulating pref-1 and leptin levels were measured. Pref-1 was significantly higher in HA subjects vs. controls (P = 0.035) and negatively associated with BMD (ρ = -0.38; P < 0.01) and bone mineral content (ρ = -0.32; P < 0.05). Metreleptin administration did not alter pref-1 levels in any study reported herein. Pref-1 is higher in HA subjects than controls. Metreleptin administration at low physiological, supraphysiological, and pharmacological doses does not affect pref-1 levels, suggesting that hypoleptinemia is not responsible for higher pref-1 levels and that leptin does not regulate pref-1.

  11. Beam loading

    OpenAIRE

    Boussard, Daniel

    1987-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superco...

  12. Length of Residence in the United States is Associated With a Higher Prevalence of Cardiometabolic Risk Factors in Immigrants: A Contemporary Analysis of the National Health Interview Survey.

    Science.gov (United States)

    Commodore-Mensah, Yvonne; Ukonu, Nwakaego; Obisesan, Olawunmi; Aboagye, Jonathan Kumi; Agyemang, Charles; Reilly, Carolyn M; Dunbar, Sandra B; Okosun, Ike S

    2016-11-04

    Cardiometabolic risk (CMR) factors including hypertension, overweight/obesity, diabetes mellitus, and hyperlipidemia are high among United States ethnic minorities, and the immigrant population continues to burgeon. Hypothesizing that acculturation (length of residence) would be associated with a higher prevalence of CMR factors, the authors analyzed data on 54, 984 US immigrants in the 2010-2014 National Health Interview Surveys. The main predictor was length of residence. The outcomes were hypertension, overweight/obesity, diabetes mellitus, and hyperlipidemia. The authors used multivariable logistic regression to examine the association between length of US residence and these CMR factors.The mean (SE) age of the patients was 43 (0.12) years and half were women. Participants residing in the United States for ≥10 years were more likely to have health insurance than those with income ratio, age, and sex, immigrants residing in the United States for ≥10 years were more likely to be overweight/obese (odds ratio [OR], 1.19; 95% CI, 1.10-1.29), diabetic (OR, 1.43; 95% CI, 1.17-1.73), and hypertensive (OR, 1.18; 95% CI, 1.05-1.32) than those residing in the United States for <10 years. In an ethnically diverse sample of US immigrants, acculturation was associated with CMR factors. Culturally tailored public health strategies should be developed in US immigrant populations to reduce CMR. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  13. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    Energy Technology Data Exchange (ETDEWEB)

    Manning, Karessa L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dolislager, Fredrick G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bellamy, Michael B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-11-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  14. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    International Nuclear Information System (INIS)

    Manning, Karessa L.; Dolislager, Fredrick G.; Bellamy, Michael B.

    2016-01-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  15. Higher neonatal growth rate and body condition score at 7 months are predictive factors of obesity in adult female Beagle dogs.

    Science.gov (United States)

    Leclerc, Lucie; Thorin, Chantal; Flanagan, John; Biourge, Vincent; Serisier, Samuel; Nguyen, Patrick

    2017-04-13

    The risks during early growth on becoming overweight in adulthood are widely studied in humans. However, early-life predictive factors for canine adult overweight and obesity have not yet been studied. To identify factors that may help explain the development of overweight and obesity at adulthood in dogs, a longitudinal study of 2 years was conducted in 24 female Beagle dogs of the same age, sexual status, and raised under identical environmental conditions. By means of a hierarchical classification on principal components with the following quantitative values: fat-free mass (FFM), percentage fat mass and pelvic circumference at 2 years of age, three groups of dogs were established and were nominally named: ideal weight (IW, n = 9), slightly overweight (OW1, n = 6) and overweight (OW2, n = 9). With the aim of identifying predictive factors of development of obesity at adulthood parental characteristics, growth pattern, energy balance and plasma factors were analysed by logistic regression analysis. At 24 months, the group compositions were in line with the body condition scores (BCS 1-9) values of the IW (5 or 6/9), the OW1 (6/9) and the OW2 (7 or 8/9) groups. Logistic regression analysis permitted the identification of neonatal growth rate during the first 2 weeks of life (GR 2W ) and BCS at 7 months as predictors for the development of obesity at adulthood. Seventy percent of dogs with either GR 2W >125% or with BCS > 6/9 at 7 months belonged to the OW2 group. Results from energy intake and expenditure, corrected for FFM, showed that there was a greater positive energy imbalance between 7 and 10 months for the OW2, compared to the IW group. This study expands the understanding of previously reported risk factors for being overweight or obese in dogs, establishing that (i) 15 out of 24 of the studied dogs became overweight and (ii) GR 2W and BCS at 7 months of age could be used as predictive factors as overweight adult dogs in the OW2

  16. Data on respiratory variables in critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+

    Directory of Open Access Journals (Sweden)

    Dimitris Georgopoulos

    2016-09-01

    Full Text Available The data show respiratory variables in 108 critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+ after at least 36 h on passive mechanical ventilation. PAV+ was continued for 48 h until the patients met pre-defined criteria either for switching to controlled modes or for breathing without ventilator assistance. Data during passive mechanical ventilation and during PAV+ are reported. Data are acquired from the whole population, as well as from patients with and without acute respiratory distress syndrome. The reported variables are tidal volume, driving pressure (ΔP, the difference between static end-inspiratory plateau pressure and positive end-expiratory airway pressure, respiratory system compliance and resistance, and arterial blood gasses. The data are supplemental to our original research article, which described individual ΔP in these patients and examined how it related to ΔP when the same patients were ventilated with passive mechanical ventilation using the currently accepted lung-protective strategy “Driving pressure during assisted mechanical ventilation. Is it controlled by patient brain?” [1]. Keywords: Tidal volume, Compliance, Driving pressure

  17. Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

    International Nuclear Information System (INIS)

    Oka, Yasuyoshi; Suzuki, Keiji; Yamauchi, Motohiro; Mitsutake, Norisato; Yamashita, Shunichi

    2011-01-01

    Highlights: → NIPBL is recruited to DSBs. → Localization of NIPBL to DSBs is regulated by MDC1 and RNF168. → HP1γ is required for NIPBL accumulation at DSBs. -- Abstract: The cohesin loading factor NIPBL is required for cohesin to associate with chromosomes and plays a role in DNA double-strand break (DSB) repair. Although the NIPBL homolog Scc2 is recruited to an enzymatically generated DSB and promotes cohesin-dependent DSB repair in yeast, the mechanism of the recruitment remains poorly understood. Here we show that the human NIPBL is recruited to the sites of DNA damage generated by micro-irradiation as well as to the sites of DSBs induced by homing endonuclease, I-PpoI. The recruitment of NIPBL was impaired by RNAi-mediated knockdown of MDC1 or RNF168, both of which also accumulate at DSBs. We also show that the recruitment of NIPBL to the sites of DNA damage is mediated by its C-terminal region containing HEAT repeats and Heterochromatin protein 1 (HP1) interacting motif. Furthermore, NIPBL accumulation at damaged sites was also compromised by HP1γ depletion. Taken together, our study reveals that human NIPBL is a novel protein recruited to DSB sites, and the recruitment is controlled by MDC1, RNF168 and HP1γ.

  18. Understanding the synergistic effect and the main factors influencing the enzymatic hydrolyzability of corn stover at low enzyme loading by hydrothermal and/or ultrafine grinding pretreatment.

    Science.gov (United States)

    Zhang, Haiyan; Li, Junbao; Huang, Guangqun; Yang, Zengling; Han, Lujia

    2018-05-26

    A thorough assessment of the microstructural changes and synergistic effects of hydrothermal and/or ultrafine grinding pretreatment on the subsequent enzymatic hydrolysis of corn stover was performed in this study. The mechanism of pretreatment was elucidated by characterizing the particle size, specific surface area (SSA), pore volume (PV), average pore size, cellulose crystallinity (CrI) and surface morphology of the pretreated samples. In addition, the underlying relationships between the structural parameters and final glucose yields were elucidated, and the relative significance of the factors influencing enzymatic hydrolyzability were assessed by principal component analysis (PCA). Hydrothermal pretreatment at a lower temperature (170 °C) combined with ultrafine grinding achieved a high glucose yield (80.36%) at a low enzyme loading (5 filter paper unit (FPU)/g substrate) which is favorable. The relative significance of structural parameters in enzymatic hydrolyzability was SSA > PV > average pore size > CrI/cellulose > particle size. PV and SSA exhibited logarithmic correlations with the final enzymatic hydrolysis yield. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1.

    Science.gov (United States)

    Wang, Cailian; Zhang, Haijun; Chen, Yan; Shi, Fangfang; Chen, Baoan

    2012-01-01

    E26 transformation-specific sequence-1 (ETS1) transcription factor plays important roles in both carcinogenesis and the progression of a wide range of malignancies. Aberrant ETS1 expression correlates with aggressive tumor behavior and a poorer prognosis in patients with various malignancies. The aim of the current study was to evaluate the efficacy of a drug delivery system utilizing gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles (GA-MNP-Fe(3)O(4)) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer cells. The effects caused by GA-MNP-Fe(3)O(4) on the proliferation of Panc-1 pancreatic cancer cells were evaluated using a MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay while inhibition of tumor cell migration was investigated in a scratch assay. The expressions of ETS1, cyclin D1, urokinase-type plasminogen activator (u-PA), and VEGF (vascular endothelial growth factor) were examined by Western blot to elucidate the possible mechanisms involved. In Panc-1 pancreatic cancer cells, we observed that application of GA-MNP-Fe(3)O(4) was able to suppress cancer cell proliferation and prevent cells from migrating effectively. After treatment, Panc-1 pancreatic cancer cells showed significantly decreased expression of ETS1, as well as its downstream target genes for cyclin D1, u-PA, and VEGF. Our novel finding reaffirmed the significance of ETS1 in the treatment of pancreatic cancer, and application of GA-MNP-Fe(3)O(4) nanoparticles targeting ETS1 should be considered as a promising contribution for better pancreatic cancer care.

  20. Do obese adults have a higher risk of asthma attack when exposed to indoor mold? A study based on the 2005 Behavioral Risk Factor Surveillance System.

    Science.gov (United States)

    Wen, Xiao-Jun; Balluz, Lina; Mokdad, Ali

    2009-01-01

    Some studies show an association between asthma and obesity, but it is unknown whether exposure to mold will increase the risk of asthma attacks among obese people. This study examined whether obese adults have a higher risk of asthma attacks than non-obese adults when exposed to indoor mold. We used data from the 2005 Behavioral Risk Factor Surveillance System to conduct a cross-sectional analysis among 9,668 respondents who reported exposure to indoor mold. With exposure to indoor mold, weighted prevalence of asthma attacks among obese respondents was 11.4% (95% confidence interval [CI] 6.0, 20.6], which was 2.3 times as high as among the exposed non-obese respondents (5.0%, 95% CI 2.8, 8.8). This ratio was almost the same as the ratio of 2.0:1 between the obese respondents (5.7%, 95% CI 4.6, 7.2) and the non-obese respondents (2.8%, 95% CI 2.3, 3.9) when neither group had exposure to mold. The odds ratio of asthma attack among obese people was 3.10 (95% CI 1.10, 8.67) for those with exposure to mold and 2.21 (95% CI 1.54, 3.17) for those without exposure to mold after adjusting for age, sex, race/ethnicity, and smoking status. Our study suggests that obese adults who have been exposed to indoor mold may not necessarily have a higher risk of asthma attack than obese adults who have not been exposed, even though obesity and exposure to indoor mold are both major risk factors for asthma attack. Medical professionals should not only incorporate weight-control or weight-reduction measures as the components of asthma treatment plans, but also advise asthma patients to avoid exposure to indoor mold.

  1. Probability Based Evaluation of Vehicular Bridge Load using Weigh-in-Motion Data

    Directory of Open Access Journals (Sweden)

    Widi Nugraha

    2016-02-01

    Full Text Available Load and Resistance Factored Design (LRFD method for designing bridge in Indonesia have been implemented for more than 25 years. LRFD method treating loads and strengths variables as random variables with specific safety factors for different loads and strengths variables type. The nominal loads, load factors, reduction factors, and other criteria for bridge design code can be determined to meet the reliability criteria. Statistical data of weigh-in-motion (WIM vehicular loads measurement in Northern Java highway, Cikampek - Pamanukan, West Java (2011, used in as statistical loads variable. A 25 m simple span bridge with reinforced concrete T-girder is used as a model for structural analysis due to WIM measured and nominal vehicular load based on RSNI T-02-2005, with applied bending moment of girder as the output. The distribution fitting result of applied bending moment due to WIM measured vehicular loads is lognormal. The maximum bending moment due to RSNI T-02-2005 nominal vehicular load is 842.45 kN-m and has probability of exceedance of 5x10-5. It can be concluded, for this study, that the bridge designed using RSNI T-02-2005 is safely designed, since it has reliability index, β of 5.02, higher than target reliability, β ranging from 3.50 or 3.72.

  2. Different Levels in Orexin Concentrations and Risk Factors Associated with Higher Orexin Levels: Comparison between Detoxified Opiate and Methamphetamine Addicts in 5 Chinese Cities

    Directory of Open Access Journals (Sweden)

    Haoran Zhang

    2013-01-01

    Full Text Available This study sought to explore the degree of orexin levels in Chinese opiate and methamphetamine addicts and the differences between them. The cross-sectional study was conducted among detoxified drug addicts from Mandatory Detoxification Center (MDC in five Chinese cities. Orexin levels were assayed with radioimmunoassay (RIA. Mann-Whitney U test and Kruskal-Wallis test were used to detect differences across groups, and logistic regression was used to explore the association between orexin levels and characteristics of demographic and drug abuse. Between November 2009 and January 2011, 285 opiates addicts, 112 methamphetamine addicts, and 79 healthy controls were enrolled. At drug withdrawal period, both opiate and methamphetamine addicts had lower median orexin levels than controls, and median orexin levels in opiate addicts were higher than those in methamphetamine addicts (all above P<0.05. Adjusted odds of the above median concentration of orexin were higher for injection than “chasing the dragon” (AOR = 3.1, 95% CI = 1.2–7.9. No significant factors associated with orexin levels of methamphetamine addicts were found. Development of intervention method on orexin system by different administration routes especially for injected opiate addicts at detoxification phase may be significant and was welcome.

  3. Contextual factors associated with treatment-seeking and higher-risk sexual behaviour in Botswana among men with symptoms of sexually transmitted infections.

    Science.gov (United States)

    Langeni, Tabitha

    2007-11-01

    This study investigates contextual factors associated with treatment-seeking behaviour and higher-risk sexual conduct of men symptomatic of sexually transmitted infections (STIs) in Botswana. Data were drawn from a randomly selected, nationally representative sample of 8 222 men, aged 15-64 years, who had reported having symptoms suggestive of an STI during the previous twelve months. Higher-risk behaviour continues to sustain the HIV epidemic in Botswana. At the heart of Botswana's epidemic lies men's reluctance to seek medical treatment, engaging in unprotected sex, and having sex with multiple partners while symptomatic of an STI. The odds of engaging in unprotected sex while symptomatic of an STI were significantly higher among teenage males and males in urban households. For every year's increase in the age difference between partners there was a 28% increase in the odds of the male having had unprotected sex. Being married and having had more than one sexual partner in the last year multiplied the odds of having unprotected sex while symptomatic of an STI by three times. The longer an infected man remained with symptoms before seeking help, the more likely it was to have unprotected sex while infected and the more likely to seek treatment from a traditional healer. Notably, having sought medical treatment from hospitals, clinics and health workers, as opposed to consulting traditional healers, significantly reduced the odds of having had unprotected sex while infected with an STI by 48%. The results indicate the need to encourage men to utilise public healthcare services. The public health sector in Botswana needs to provide healthcare services that are user-friendly for men. Increasing the number of treatment sites may also contribute to preventing onward transmission of STIs. Special attention needs to be paid to boys' socialisation towards gender norms, and men are to be encouraged to play a responsible role in HIV prevention.

  4. Factors influencing maternal decision-making for the infant sleep environment in families at higher risk of SIDS: a qualitative study.

    Science.gov (United States)

    Pease, Anna; Ingram, Jenny; Blair, Peter S; Fleming, Peter J

    2017-01-01

    Qualitative interviews with mothers of babies at higher risk of sudden infant death syndrome (SIDS) were carried out to understand their views and decision-making process on the infant sleep environment and safe sleep messages. Twenty semi-structured interviews were conducted between February and November 2014 in deprived areas of Bristol, UK. Mothers were asked about their decision-making for the infant sleep environment and safe sleep messages including infant sleep position, co-sleeping, smoking, dummy use, feeding and disrupted routines. The interviews were transcribed, coded and thematic analysis carried out. Participants were invited based on an algorithm developed in a previous SIDS case control study that identified an increased risk of SIDS from four demographic characteristics: young maternal age, smoking during pregnancy, three or more children, and a measure of deprivation. The presence of three, or more characteristics led to being invited to take part in the qualitative study. Factors influencing mothers' adherence to the safe sleep messages included previous experience and the credibility of the advice given. They described disrupted routines that led to risky scenarios with a belief that occasional risks were acceptable. Where circumstances made following the advice more difficult they found alternative strategies to reduce the risk, including the use of movement monitors, regular checking and a belief that lighter maternal sleep in the presence of a baby was protective. Safer sleep messages should be tailored to fit with the lived realities of mothers, especially those at higher risk. The traditional list of 'do's' and 'don'ts' was not well accepted by this group. Interventions that seek to influence this higher-risk group should acknowledge mothers' own protective instincts and consider their beliefs and understanding behind the safer sleep messages if they are to be effective and encourage this group to change.

  5. A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein.

    Science.gov (United States)

    Xiao, Yangming; Russell, I Jon; Liu, Ya-Guang

    2012-08-01

    A common single nucleotide polymorphism (SNP) in the gene of brain-derived neurotrophic factor (BDNF) results from a substitution at position 66 from valine (Val) to methionine (Met) and may predispose to human neuropsychiatric disorders. We proposed to determine whether these BDNF gene SNPs were associated with fibromyalgia syndrome (FMS) and/or any of its typical phenotypes. Patients with FMS (N = 95) and healthy normal controls (HNC, N = 58) were studied. Serum high-sensitivity C-reactive protein (hsCRP) levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BDNF SNPs were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The BDNF SNP distribution was 65 (68%) Val/Val, 28 (30%) Val/Met, and 2 (2%) Met/Met for FMS and 40 (69%), 17(29%), and 1 (2%) for HNC, respectively. The serum high-sensitivity C-reactive protein (hsCRP)and body mass index (BMI) in FMS were higher than in HNC. The FMS with BDNF Val66Val had significantly higher mean BMI (P = 0.0001) and hsCRP (P = 0.02) than did FMS carrying the Val66Met genotype. This pattern was not found in HNC. Phenotypic measures of subjective pain, pain threshold, depression, or insomnia did not relate to either of the BDNF SNPs in FMS. The relative distribution BDNF SNPs did not differ between FMS and HNC. The BDNF Val66Met polymorphism is not selective for FMS. The BDNF Val66Val SNP identifies a subgroup of FMS with elevated hsCRP and higher BMI. This is the first study to associate a BDNF polymorphism with a FMS subgroup phenotype.

  6. Higher Income and Integration into the Workforce Are the Main Factors Associated with Quality of Life in Acromegalic Patients in Northeastern Brazil.

    Science.gov (United States)

    GuimarãesSá, Adriana Maria; Ferreira, Pedro Antônio Muniz; Souza, Marinilde Teles; Nascimento, Gilvan Cortês; da Silva Pereira Damianse, Sabrina; de Carvalho Rocha, Viviane Chaves; Dos Santos Faria, Manuel; de Souza Paiva Ferreira, Adalgisa

    2018-01-01

    To identify the factors associated with quality of life in patients with acromegaly with follow-up at the referral service in neuroendocrinology of the state of Maranhão, northeast Brazil. The Acromegaly Quality of Life Questionnaire (Acro-QoL) was used. Factors independently associated with quality of life were identified using multivariate linear regression, with p values integrated into the job market and quality of life scores in the overall domain ( β = 0.288, p = 0.003), psychological domain ( β = 0.291, p = 0.032), and personal relationship domain ( β = 0.314, p = 0.019). We also observed a positive association with income and the quality of life scores in all domains as follows: overall domain ( β = 0.037, p = 0.003), physical domain ( β = 0.988, p = 0.001), psychological domain ( β = 0.342, p = 0.008), physical appearance domain ( β = 0.270, p = 0.049), and personal relationship domain ( β = 0.315, p = 0.012). For patients with acromegaly living in one of the least developed regions of Brazil, integration into the job market and a higher income were associated with a better quality of life.

  7. Higher Education

    African Journals Online (AJOL)

    Kunle Amuwo: Higher Education Transformation: A Paradigm Shilt in South Africa? ... ty of such skills, especially at the middle management levels within the higher ... istics and virtues of differentiation and diversity. .... may be forced to close shop for lack of capacity to attract ..... necessarily lead to racial and gender equity,.

  8. Awareness of female students attending higher educational institutions toward legalization of safe abortion and associated factors, Harari Region, Eastern Ethiopia: a cross sectional study.

    Science.gov (United States)

    Geleto, Ayele; Markos, Jote

    2015-03-17

    Unsafe abortion has been recognized as an important public health problem in the world. It accounts for 14% of all maternal deaths in sub-Saharan African countries. In Ethiopia, 32% of all maternal deaths are accounted to unsafe abortion. Taking the problem of unsafe abortion into consideration, the penal code of Ethiopia was amended in 2005, to permit safe abortion under a set of circumstances. However, lack of awareness on the revised penal code is a major barrier that hinders women to seek safe abortion. The aim of this study is to assess awareness of female students attending higher educational institutions toward legalization of safe abortion and associated factors in Harari region, eastern Ethiopia. Institution-based descriptive cross sectional study was conducted among 762 female students who are attending five higher educational institutions in Harari Region. Systematic sampling method was used to identify study participants from randomly selected colleges. Self administered structured questionnaire was used to collect data. Data were entered in to Epi Info version 6.04 and analyzed by SPSS version 17.0 statistical packages. Frequency, percentage and ratio were used to describe variables. Multivariable logistic regression analysis was done to control confounders and odds ratio with 95% confidence interval was used to identify factors associated with awareness of female students to legalization of abortion. 762 study participants completed the survey questionnaire making the response rate 90.2%. Only 272 (35.7%) of the respondents reported that they have good awareness about legalization of safe abortion. Studying other fields than health and medicine [AOR 0.48; 95%CI (0.23, 0.85)], being the only child for their family [AOR 0.28; 95%CI (0.13, 0.86)], having no boy friend [AOR 0.34; 95%CI (0.12, 0.74)], using family planning [AOR 0.50; 95%CI (0.13 and 0.86)], being 25 years or older [AOR 1.64; 95%CI (1.33, 2.80)] were significantly associated with awareness

  9. Beam loading

    CERN Document Server

    Gamp, Alexander

    2013-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superconducting cavities are also given. Finally, a dedicated phase loop for damping synchrotron oscillations is discussed.

  10. Beam loading

    International Nuclear Information System (INIS)

    Gamp, Alexander

    2013-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superconducting cavities are also given. Finally, a dedicated phase loop for damping synchrotron oscillations is discussed. (author)

  11. FACTORES PARA LA NO NEUTRALIDAD DE LA EVALUACIÓN DE LA CALIDAD DE LA EDUCACIÓN SUPERIOR (FACTORS FOR NON-NEUTRALITY OF THE EVALUATION OF THE HIGHER EDUCATION QUALITY

    Directory of Open Access Journals (Sweden)

    Vizcarra Herles Nina Eleonor

    2011-08-01

    Full Text Available Resumen:En el presente ensayo, los autores con base en la revisión de fuentes bibliográficas, abordan el tema de la no neutralidad de la evaluación de la calidad de la educación superior, se identifican factores de la no neutralidad en la evaluación y en la calidad relacionados con: el referente (modelo de referencia utilizado para la evaluación, las dimensiones explicativo-relacionales de la calidad y las demandas de calidad formuladas por actores sociales; estos factores expresan el propósito del evaluador, componente ideológico que determina la no neutralidad de la evaluación de la calidad. Se infiere que para los sistemas nacionales de evaluación la definición y la mejora de la calidad de la educación superior compromete la participación multisectorial.Abstract: In this essay, the authors based on a review of literature sources, address the issue of non-neutrality of the evaluation of the quality of higher education, identify factors of non-neutrality in the evaluation and quality related to: the reference model used for evaluation, the explanatory-relational dimensions of quality and quality demands made by social actors; these factors express the purpose of evaluator, ideological component that determines the non-neutrality of quality assessment. It is inferred that for the national assessment systems; the definition and the improving of the quality of higher education undertake multi-stakeholder participation.

  12. Peak load-impulse characterization of critical pulse loads in structural dynamics

    International Nuclear Information System (INIS)

    Abrahamson, G.R.; Lindberg, H.E.

    1975-01-01

    In presenting the characterization scheme, some general features are described first. A detailed analysis is given for the rigid-plastic system of one degree of freedom to illustrate the calculation of critical load curves in terms of peak load and impulse. This is followed by the presentation of critical load curves for uniformly loaded rigid-plastic beams and plates and for dynamic buckling of cylindrical shells under uniform lateral loads. The peak load-impulse characterization of critical pulse loads is compared with the dynamic load factor characterization, and some aspects of the history of the peak load-pulse scheme are presented. (orig./HP) [de

  13. Higher Education

    Science.gov (United States)

    & Development (LDRD) National Security Education Center (NSEC) Office of Science Programs Richard P Databases National Security Education Center (NSEC) Center for Nonlinear Studies Engineering Institute Scholarships STEM Education Programs Teachers (K-12) Students (K-12) Higher Education Regional Education

  14. Load sensor

    NARCIS (Netherlands)

    Van den Ende, D.; Almeida, P.M.R.; Dingemans, T.J.; Van der Zwaag, S.

    2007-01-01

    The invention relates to a load sensor comprising a polymer matrix and a piezo-ceramic material such as PZT, em not bedded in the polymer matrix, which together form a compos not ite, wherein the polymer matrix is a liquid crystalline resin, and wherein the piezo-ceramic material is a PZT powder

  15. Carbohydrate Loading.

    Science.gov (United States)

    Csernus, Marilyn

    Carbohydrate loading is a frequently used technique to improve performance by altering an athlete's diet. The objective is to increase glycogen stored in muscles for use in prolonged strenuous exercise. For two to three days, the athlete consumes a diet that is low in carbohydrates and high in fat and protein while continuing to exercise and…

  16. Higher Efficiency HVAC Motors

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, Charles Joseph [QM Power, Inc., Kansas City, MO (United States)

    2018-02-13

    The objective of this project was to design and build a cost competitive, more efficient heating, ventilation, and air conditioning (HVAC) motor than what is currently available on the market. Though different potential motor architectures among QMP’s primary technology platforms were investigated and evaluated, including through the building of numerous prototypes, the project ultimately focused on scaling up QM Power, Inc.’s (QMP) Q-Sync permanent magnet synchronous motors from available sub-fractional horsepower (HP) sizes for commercial refrigeration fan applications to larger fractional horsepower sizes appropriate for HVAC applications, and to add multi-speed functionality. The more specific goal became the research, design, development, and testing of a prototype 1/2 HP Q-Sync motor that has at least two operating speeds and 87% peak efficiency compared to incumbent electronically commutated motors (EC or ECM, also known as brushless direct current (DC) motors), the heretofore highest efficiency HVACR fan motor solution, at approximately 82% peak efficiency. The resulting motor prototype built achieved these goals, hitting 90% efficiency and .95 power factor at full load and speed, and 80% efficiency and .7 power factor at half speed. Q-Sync, developed in part through a DOE SBIR grant (Award # DE-SC0006311), is a novel, patented motor technology that improves on electronically commutated permanent magnet motors through an advanced electronic circuit technology. It allows a motor to “sync” with the alternating current (AC) power flow. It does so by eliminating the constant, wasteful power conversions from AC to DC and back to AC through the synthetic creation of a new AC wave on the primary circuit board (PCB) by a process called pulse width modulation (PWM; aka electronic commutation) that is incessantly required to sustain motor operation in an EC permanent magnet motor. The Q-Sync circuit improves the power factor of the motor by removing all

  17. Factors that Influence the Teaching-Learning Process from the Perspective of Accountancy Students: Analysis at a Higher Education Institution in Minas Gerais

    Directory of Open Access Journals (Sweden)

    Caroline Stéffani Santos Nério Pavione

    2016-06-01

    Full Text Available The aim of this study is to identify the factors that influence the process of teaching and learning according to the students in the Accountancy course at a Higher Education Institution (HEI in the state of Minas Gerais. The survey was conducted by applying a questionnaire, totaling 124 valid responses. The results were combined and confronted with perceptions obtained in past research. The following variables stood out that most influenced the teaching-learning process according to the students: "teacher's didactics (how the teacher leads the class, interacts with students and provides for a learning environment"; "Content structure of the course"; "Desire to learn the subject (personal motivation for the subject"; and "library equipped with an extensive collection of books and appropriate facilities", each in one dimension: teacher, subject, student and institution. The attitudes of students and teachers could also be identified that, according to the students, influenced the achievement of ideal teaching and learning most negatively. As a result, the four highest scores were attitudes in relation to the student, "lack of interest" and "lack of dedication outside the classroom"; to the teacher, "does not intend to address the concerns of students" and not "mastering the subject matter to be explained." Thus, discussions on improving the process of teaching and learning in Accounting can be promoted based on the analysis of the variables listed. The researchers expect to contribute to the identification of the major errors in the process of teaching and learning from the perspective of the key stakeholders (students in order to facilitate discussions in order to solve them and, ultimately, to culminate in improvements in the Accounting course and reduce the dropout rates in higher education.

  18. A FACTOR ANALYSIS OF ATTITUDE OF EDUCATION FRATERNITY TOWARDS THE ROLE OF TECHNOLOGY IN EFFECTIVE LEARNING: AN EMPIRICAL STUDY IN HIGHER EDUCATION INSTITUTION

    Directory of Open Access Journals (Sweden)

    Kapoor Toran

    2013-06-01

    Full Text Available Use of Technology is empowering teachers and students, and enhancing teaching and students’ achievement which has been highlighted in several studies. Well planned lessons integrating technology are often more engaging, memorable and inspiring to students (Tornabene, 1998. Attitudes refer to one’s positive or negative judgment about a concrete subject. Attitude is a major predictor of future use of technology. Student teachers have positive attitude and are highly enthusiastic about interactive whiteboards as an important feature of teaching and learning, and this motivated them to practice using the technology (Kennewell, & Morgan, 2003. The purpose is to create new opportunities in teaching and learning by integrating computer, multimedia, and network technologies. However, it is not clear whether use of this new technology will automatically result in effective learning or make students dependent on technology to learn. Will Students use Technology appropriately? The same doubts prevailed with the invention of the printing press, radio, and television. All of them have positively contributed in access to information that can be transformed into knowledge and wisdom thereafter. Proper use of technology can become an effective tool to enhance learning. This research is an attempt in understanding the attitude of teachers as well as students towards the role of technology in higher education. The study is based on primary data collected through a sample size of 130 units consisting of 100 students and 30 teachers from universities located in NCR, India. Factor analysis has been conducted to measure the attitude of the teachers and the students. The study was been conducted in NCR, India and leaves the scope of further research in Higher Education across the globe.

  19. Design of a 4 1/2 stage turbine with a stage loading factor of 4.66 and high specific work output

    Science.gov (United States)

    Webster, P. F.

    1976-01-01

    The aerodynamic design of a highly loaded multistage fan drive turbine is discussed. Turbine flowpath and airfoil sections are presented along with respective pressure and velocity distributions. Vibrational modes are identified in the expected turbine operating range.

  20. Factors associated with recent unsuppressed viral load in HIV-1-infected patients in care on first-line antiretroviral therapy in South Africa.

    Science.gov (United States)

    Joseph Davey, D; Abrahams, Z; Feinberg, M; Prins, M; Serrao, C; Medeossi, B; Darkoh, E

    2018-05-01

    Unsuppressed viral load (VL) in patients on antiretroviral therapy (ART) occurs when treatment fails to suppress a person's VL and is associated with decreased survival and increased HIV transmission. The objective of this study was to evaluate factors associated with unsuppressed VL (VL > 400 copies/ml) in patients currently in care on first-line ART for ≥ 6 months attending South African public healthcare facilities. We analysed electronic medical records of ART patients with a VL result on record who started ART between January 2004 and April 2016 from 271 public health facilities. We present descriptive and multivariable logistic regression for unsuppressed VL at last visit using a priori variables. We included 244,370 patients (69% female) on first-line ART in April 2016 for ≥ 6 months. Median age at ART start was 33 years (7% were < 15 years old). Median duration on ART was 3.7 years. Adjusting for other variables, factors associated with having an unsuppressed VL at the most recent visit among patients in care included: (1) < 15 years old at ART start (adjusted odds ratio [aOR]=2.58; 95% CI = 2.37, 2.81) versus 15-49 years at ART start, (2) male gender (aOR = 1.29; 95% CI = 1.25, 1.35), (3) 6-12 months on ART versus longer (aOR = 1.34; 95% CI = 1.29, 1.40), (4) on tuberculosis (TB) treatment (aOR = 1.78; 95% CI = 1.48, 2.13), and (5) prior ART exposure versus none (aOR = 1.20; 95% CI = 1.08, 1.32). Approximately 85% of the ART cohort who were in care had achieved viral suppression, though men, youth/adolescents, patients with prior ART exposure, those with short duration of ART, and patients on TB treatment had increased odds of not achieving viral suppression. There is a need to develop and evaluate targeted interventions for ART patients in care who are at high risk of unsuppressed VL.

  1. Seismic Loading for FAST: May 2011 - August 2011

    Energy Technology Data Exchange (ETDEWEB)

    Asareh, M. A.; Prowell, I.

    2012-08-01

    As more wind farms are constructed in seismically active regions, earthquake loading increases in prominence for design and analysis of wind turbines. Early investigation of seismic load tended to simplify the rotor and nacelle as a lumped mass on top of the turbine tower. This simplification allowed the use of techniques developed for conventional civil structures, such as buildings, to be easily applied to wind turbines. However, interest is shifting to more detailed models that consider loads for turbine components other than the tower. These improved models offer three key capabilities in consideration of base shaking for turbines: 1) The inclusion of aerodynamics and turbine control; 2) The ability to consider component loads other than just tower loads; and 3) An improved representation of turbine response in higher modes by reducing modeling simplifications. Both experimental and numerical investigations have shown that, especially for large modern turbines, it is important to consider interaction between earthquake input, aerodynamics, and operational loads. These investigations further show that consideration of higher mode activity may be necessary in the analysis of the seismic response of turbines. Since the FAST code is already capable of considering these factors, modifications were developed that allow simulation of base shaking. This approach allows consideration of this additional load source within a framework, the FAST code that is already familiar to many researchers and practitioners.

  2. A Systematic Review on Immediate Loading of Implants Used to Support Overdentures Opposed by Conventional Prostheses: Factors That Might Influence Clinical Outcomes.

    Science.gov (United States)

    Zygogiannis, Kostas; Wismeijer, Daniel; Aartman, Irene Ha; Osman, Reham B

    2016-01-01

    Different treatment protocols in terms of number, diameter, and suprastructure design have been proposed for immediately loaded implants that are used to support mandibular overdentures opposed by maxillary conventional dentures. The aim of this study was to investigate the influence of these protocols on survival rates as well as clinical and prosthodontic outcomes. Several electronic databases were searched for all relevant articles published from 1966 to June 2014. Only randomized controlled trials and prospective studies with a minimum follow-up of 12 months were selected. The primary outcomes of interest were the success and survival rates of the implants. Prosthodontic complications were also evaluated. Fourteen studies fulfilled the inclusion criteria. Of the studies identified, nine were randomized controlled trials and five were prospective studies. The mean follow-up period was 3 years or less for the vast majority of the studies. The reported survival and success rates were comparable to that of conventional loading for most of the included studies. No specific immediate loading protocol seemed to perform better in terms of clinical and prosthodontic outcomes. Immediate loading protocols of mandibular overdentures seem to be a viable alternative to conventional loading. It was not possible to recommend a specific treatment protocol related to the number, diameter of the implants, and attachment system used. Long-term, well-designed studies comparing different immediate loading modalities could help to establish a protocol that delivers the most clinically predictable, efficient, and cost-effective outcome for edentulous patients in need of implant overdentures.

  3. Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms

    International Nuclear Information System (INIS)

    Haselbacher, G.K.; Schwab, M.E.; Pasi, A.; Humbel, R.E.

    1985-01-01

    Twenty-four distinct areas of human brain were analyzed for the presence of insulin-like growth factor (IGF). As reported for cerebrospinal fluid, only IGF II-like immunoreactivity, but no significant amounts of IGF I-like immunoreactivity, could be found. Upon gel permeation chromatography, two to five distinct size classes were separated on the basis of their immunoreactivity. Radioimmunoassays and a bioassay also gave results indistinguishable from those of serum IGF II. The highest amounts of IGF II-like immunoreactivity occur in the anterior pituitary. This is up to 100 times more than in most other brain regions analyzed. The higher molecular mass immunoreactive species were partially characterized. After immunoaffinity purification, the 38- and 26-kDa species are active in a bioassay. Specific IGF-binding protein activity could be shown after purification of the 38- and 26-kDa species on an IGF-affinity column. The 13-kDa species released significant amounts of 7.5-kDa material. The results are interpreted as evidence for the presence of IGF II synthesized locally in human brain

  4. Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

    Science.gov (United States)

    Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

    2017-05-01

    Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

  5. Higher Education.

    Science.gov (United States)

    Hendrickson, Robert M.

    This chapter reports 1982 cases involving aspects of higher education. Interesting cases noted dealt with the federal government's authority to regulate state employees' retirement and raised the questions of whether Title IX covers employment, whether financial aid makes a college a program under Title IX, and whether sex segregated mortality…

  6. Load sensor

    OpenAIRE

    Van den Ende, D.; Almeida, P.M.R.; Dingemans, T.J.; Van der Zwaag, S.

    2007-01-01

    The invention relates to a load sensor comprising a polymer matrix and a piezo-ceramic material such as PZT, em not bedded in the polymer matrix, which together form a compos not ite, wherein the polymer matrix is a liquid crystalline resin, and wherein the piezo-ceramic material is a PZT powder forming 30-60% by volume of the composite, and wherein the PZT powder forms 40-50% by volume of the composite.

  7. Behaviour of eggshell membranes at tensile loading

    Czech Academy of Sciences Publication Activity Database

    Strnková, M.J.; Nedomová, Š.; Trnka, Jan; Buchar, J.; Kumbár, V.

    46 B, December (2014), s. 44-48 ISSN 0324-1130 Institutional support: RVO:61388998 Keywords : eggshell membrane * tensile loading * loading rate * stress * strain strength Subject RIV: GM - Food Processing Impact factor: 0.201, year: 2014

  8. Experimental Investigations on Axially and Eccentrically Loaded Masonry Walls

    Science.gov (United States)

    Keshava, Mangala; Raghunath, Seshagiri Rao

    2017-12-01

    In India, un-reinforced masonry walls are often used as main structural components in load bearing structures. Indian code on masonry accounts the reduction in strength of walls by using stress reduction factors in its design philosophy. This code was introduced in 1987 and reaffirmed in 1995. The present study investigates the use of these factors for south Indian masonry. Also, with the gaining popularity in block work construction, the aim of this study was to find out the suitability of these factors given in the Indian code to block work masonry. Normally, the load carrying capacity of masonry walls can be assessed in three ways, namely, (1) tests on masonry constituents, (2) tests on masonry prisms and (3) tests on full-scale wall specimens. Tests on bricks/blocks, cement-sand mortar, brick/block masonry prisms and 14 full-scale brick/block masonry walls formed the experimental investigation. The behavior of the walls was investigated under varying slenderness and eccentricity ratios. Hollow concrete blocks normally used as in-fill masonry can be considered as load bearing elements as its load carrying capacity was found to be high when compared to conventional brick masonry. Higher slenderness and eccentricity ratios drastically reduced the strength capacity of south Indian brick masonry walls. The reduction in strength due to slenderness and eccentricity is presented in the form of stress reduction factors in the Indian code. These factors obtained through experiments on eccentrically loaded brick masonry walls was lower while that of brick/block masonry under axial loads was higher than the values indicated in the Indian code. Also the reduction in strength is different for brick and block work masonry thus indicating the need for separate stress reduction factors for these two masonry materials.

  9. Associated factors for higher lead and cadmium blood levels, and reference values derived from general population of São Paulo, Brazil

    International Nuclear Information System (INIS)

    Kira, Carmen Silvia; Sakuma, Alice Momoyo; De Capitani, Eduardo Mello; Umbelino de Freitas, Clarice; Cardoso, Maria Regina Alves; Gouveia, Nelson

    2016-01-01

    Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20 years old, 264 adolescents aged 12 to 19 years old and 391 children under 11 years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20 years old were 33 μg/L and 0.6 μg/L, respectively, for adolescents (12 to 19 years old) were 31 μg/L and 0.6 μg/L, respectively and for children under 11 years old were 29 μg/L and 0.2 μg/L, respectively. The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low. - Highlights: • The exposure of population of São Paulo city to lead and cadmium is low. • Pb level was associated with gender, smoking, offal intake, area of residence, age. • Cd level was associated with gender, smoking, distilled beverages, age. • RV for Pb in blood for children and adolescents were 29 and 31 μg/L, respectively. • RV for Cd in blood for children and adolescents were 0.2 and 0.6 μg/L, respectively.

  10. Associated factors for higher lead and cadmium blood levels, and reference values derived from general population of São Paulo, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Kira, Carmen Silvia, E-mail: carmkira@ial.sp.gov.br [Instituto Adolfo Lutz, Centro de Materiais de Referência, Av. Dr. Arnaldo, 355, São Paulo, SP CEP 01246-000 (Brazil); Sakuma, Alice Momoyo [Instituto Adolfo Lutz, Centro de Materiais de Referência, Av. Dr. Arnaldo, 355, São Paulo, SP CEP 01246-000 (Brazil); De Capitani, Eduardo Mello [Universidade Estadual de Campinas — UNICAMP, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Centro de Controle de Intoxicações (Brazil); Umbelino de Freitas, Clarice [Secretaria de Estado da Saúde/SP, Coordenadoria de Controle de Doenças (Brazil); Cardoso, Maria Regina Alves [Universidade de São Paulo, Faculdade de Saúde Pública, Departamento de Epidemiologia (Brazil); Gouveia, Nelson [Universidade de São Paulo — USP, Faculdade de Medicina, Departamento de Medicina Preventiva (Brazil)

    2016-02-01

    Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20 years old, 264 adolescents aged 12 to 19 years old and 391 children under 11 years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20 years old were 33 μg/L and 0.6 μg/L, respectively, for adolescents (12 to 19 years old) were 31 μg/L and 0.6 μg/L, respectively and for children under 11 years old were 29 μg/L and 0.2 μg/L, respectively. The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low. - Highlights: • The exposure of population of São Paulo city to lead and cadmium is low. • Pb level was associated with gender, smoking, offal intake, area of residence, age. • Cd level was associated with gender, smoking, distilled beverages, age. • RV for Pb in blood for children and adolescents were 29 and 31 μg/L, respectively. • RV for Cd in blood for children and adolescents were 0.2 and 0.6 μg/L, respectively.

  11. What does germane load mean? An empirical contribution to the cognitive load theory.

    Science.gov (United States)

    Debue, Nicolas; van de Leemput, Cécile

    2014-01-01

    While over the last decades, much attention has been paid to the mental workload in the field of human computer interactions, there is still a lack of consensus concerning the factors that generate it as well as the measurement methods that could reflect workload variations. Based on the multifactorial Cognitive Load Theory (CLT), our study aims to provide some food for thought about the subjective and objective measurement that can be used to disentangle the intrinsic, extraneous, and germane load. The purpose is to provide insight into the way cognitive load can explain how users' cognitive resources are allocated in the use of hypermedia, such as an online newspaper. A two-phase experiment has been conducted on the information retention from online news stories. Phase 1 (92 participants) examined the influence of multimedia content on performance as well as the relationships between cognitive loads and cognitive absorption. In Phase 2 (36 participants), eye-tracking data were collected in order to provide reliable and objective measures. Results confirmed that performance in information retention was impacted by the presence of multimedia content such as animations and pictures. The higher number of fixations on these animations suggests that users' attention could have been attracted by them. Results showed the expected opposite relationships between germane and extraneous load, a positive association between germane load and cognitive absorption and a non-linear association between intrinsic and germane load. The trends based on eye-tracking data analysis provide some interesting findings about the relationship between longer fixations, shorter saccades and cognitive load. Some issues are raised about the respective contribution of mean pupil diameter and Index of Cognitive Activity.

  12. Occurrence of Malnutrition and Associated Factors in Community-Dwelling Older Adults: Those with a Recent Diagnosis of Cancer Are at Higher Risk.

    Science.gov (United States)

    Van Den Broeke, C; De Burghgraeve, T; Ummels, M; Gescher, N; Deckx, L; Tjan-Heijnen, V; Buntinx, F; van den Akker, M

    2018-01-01

    In older adults, nutritional health is essential for good quality of life and living independently at home. Especially in cancer patients, malnutrition is common and known to complicate treatment. This study aims to evaluate the nutritional status and its associated factors in community-dwelling older adults with and without cancer. This is an observational study. This study focuses on older community-dwelling people. This study included older people with and without cancer (≥70 years). Cancer patients included patients with a new diagnosis of breast, lung, prostate, or colorectal cancer. Data collection included measures of nutritional status, quality of life, depression, fatigue, distress and functional status. We used multivariate logistic regression analysis to assess the association between personal characteristics and malnutrition. Data were available for 657 people; 383 people without cancer and 274 with a cancer diagnosis. Overall, malnutrition was detected in 245 (37.5%) people; in cancer patients this was 66.1%. Multivariate analysis showed that having cancer (OR 14.4, 95% CI: 8.01 - 23.3), being male (OR 2.38, 95% CI: 1.49 - 3.70), having depression (OR 13.5, 95% CI: 6.02-30.0), distress (OR 2.60, 95% CI: 1.55 - 4.37) and impaired instrumental activities of daily living (IADL) (OR 2.63, 95% CI: 1.63 - 4.24) were associated with a higher risk of malnutrition. The prevalence of malnutrition in community-dwelling older people is high, particularly in patients with cancer. Benchmarking and routine screening of older patients may be helpful strategies to increase awareness of (risk of) malnutrition among professionals.

  13. Dynamic Regression Intervention Modeling for the Malaysian Daily Load

    Directory of Open Access Journals (Sweden)

    Fadhilah Abdrazak

    2014-05-01

    Full Text Available Malaysia is a unique country due to having both fixed and moving holidays.  These moving holidays may overlap with other fixed holidays and therefore, increase the complexity of the load forecasting activities. The errors due to holidays’ effects in the load forecasting are known to be higher than other factors.  If these effects can be estimated and removed, the behavior of the series could be better viewed.  Thus, the aim of this paper is to improve the forecasting errors by using a dynamic regression model with intervention analysis.   Based on the linear transfer function method, a daily load model consists of either peak or average is developed.  The developed model outperformed the seasonal ARIMA model in estimating the fixed and moving holidays’ effects and achieved a smaller Mean Absolute Percentage Error (MAPE in load forecast.

  14. Effect of water deprivation, desmopressin (DDAVP) infusion, and oral loads of water, Na+ and NH4+ on urinary excretion of epidermal growth factor in the rat

    DEFF Research Database (Denmark)

    Jørgensen, P E; Poulsen, Steen Seier; Nexø, Ebba

    1993-01-01

    for urinary EGF we examined the effects of changes in the oral loads of water, Na+ and NH4+ as well as the effect of infusion of the vasopressin analogue, desmopressin (DDAVP) on the endogenous urinary EGF excretion in the rat. Water deprivation for 48 h reduced the urinary excretion of EGF by 25...

  15. Load equivalency factors (LEFs) for abnormal vehicles (AVs) and mobile cranes in South Africa based on the mechanistic-empirical (M-E) design methodology

    CSIR Research Space (South Africa)

    De Beer, Morris

    2009-07-01

    Full Text Available layer life of pavement under the loading of Axle of vehicle in question. v n ii=1 Total Additional Damage of Vehicle = TAD (Ncritical from Standard 80 kN/520 kPa Axle) (Ncritical from Legal 88 kN/700 kPa Axle) -(Ncritical from Axle...

  16. A systematic review on immediate loading of implants used to support overdentures opposed by conventional prostheses : factors that might influence clinical outcomes

    NARCIS (Netherlands)

    Zygogiannis, K.; Wismeijer, D.; Aartman, I.H.A.; Osman, R.B.

    2016-01-01

    Purpose: Different treatment protocols in terms of number, diameter, and suprastructure design have been proposed for immediately loaded implants that are used to support mandibular overdentures opposed by maxillary conventional dentures. The aim of this study was to investigate the influence of

  17. Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Chiu-Yen Chung

    2017-03-01

    Full Text Available Brain derived neurotrophic factor (BDNF can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC was constructed to deliver plasmid DNAs (pDNAs containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF. The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting. The HRE-cmvBDNF appeared to adsorb onto the surface of PS80 PBCA NC, with a resultant mean diameter of 92.6 ± 1.0 nm and zeta potential of −14.1 ± 1.1 mV. HIF-1α level in iPSCs was significantly higher in hypoxia, which resulted in a 51% greater BDNF expression when transfected with PS80 PBCA NC/HRE-cmvBDNF than those without hypoxia. TrkB and phospho-Akt were also elevated which correlated with neural differentiation. The findings suggest that PS80 PBCA NC too can be endocytosed to serve as an efficient vector for genes coupled to the HRE in hypoxia-sensitive cells, and activation of the PI3/Akt pathway in iPSCs by BDNF is capable of neural lineage specification.

  18. The role of the vascular endothelial growth factor/vascular endothelial growth factor receptors axis mediated angiogenesis in curcumin-loaded nanostructured lipid carriers induced human HepG2 cells apoptosis

    Directory of Open Access Journals (Sweden)

    Fengling Wang

    2015-01-01

    Full Text Available Background: Curcumin (diferuloylmethane, the active constituent of turmeric extract has potent anti-cancer properties have been demonstrated in hepatocellular carcinoma (HCC. However, its underlying molecular mechanism of therapeutic effects remains unclear. Vascular endothelial growth factor (VEGF and its receptors (VEGFRs have crucial roles in tumor angiogenesis. Purpose: The goal of this study was to investigate the role of the VEGF/VEGFRs mediated angiogenesis during the proliferation and apoptosis of human HepG2 hepatoma cell line and the effect of curcumin-loaded nanostructured lipid carriers (Cur-NLC. Materials and Methods: The proliferation of HepG2 cells was determined by methyl thiazolyl tetrazolium after exposure to Cur-NLC and native curcumin. Apoptosis was quantified by flow cytometry with annexin V-fluorescein isothiocyanate and propidium iodide staining. Cellular internalization of Cur-NLC was observed by fluorescent microscope. The level of VEGF was detected by enzyme-linked immunosorbent assay kits. The expression of VEGFRs was quantified by Western blotting. Results: Cur-NLC was more effective in inhibiting the proliferation and enhancing the apoptosis of HepG2 cells than native curcumin. Fluorescent microscope analysis showed that HepG2 cells internalized Cur-NLC more effectively than native curcumin. Furthermore, Cur-NLC down-regulated the level of VEGF and the expression of VEGFR-2, but had a slight effect on VEGFR-1. Conclusion: These results clearly demonstrated that Cur-NLC was more effective in anti-cancer activity than the free form of curcumin. These studies demonstrate for the 1 st time that Cur-NLC exerts an antitumor effect on HepG2 cells by modulating VEGF/VEGFRs signaling pathway.

  19. Treatment Results of Postoperative Radiotherapy on Squamous Cell Carcinoma of the Oral Cavity: Coexistence of Multiple Minor Risk Factors Results in Higher Recurrence Rates

    International Nuclear Information System (INIS)

    Fan, Kang-Hsing; Wang, Hung-Ming; Kang, Chung-Jan

    2010-01-01

    Purpose: The aim of this study was to investigate the treatment results of postoperative radiotherapy (PORT) on squamous cell carcinoma of the oral cavity (OSCC). Materials and Methods: This study included 302 OSCC patients who were treated by radical surgery and PORT. Indications for PORT include Stage III or IV OSCC according to the 2002 criteria of the American Joint Committee on Cancer, the presence of perineural invasion or lymphatic invasion, the depth of tumor invasion, or a close surgical margin. Patients with major risk factors, such as multiple nodal metastases, a positive surgical margin, or extracapsular spreading, were excluded. The prescribed dose of PORT ranged from 59.4 to 66.6Gy (median, 63Gy). Results: The 3-year overall and recurrence-free survival rates were 73% and 70%, respectively. Univariate analysis revealed that differentiation, perineural invasion, lymphatic invasion, bone invasion, location (hard palate and retromolar trigone), invasion depths ≥10mm, and margin distances ≤4mm were significant prognostic factors. The presence of multiple significant factors of univariate analysis correlated with disease recurrence. The 3-year recurrence-free survival rates were 82%, 76%, and 45% for patients with no risk factors, one or two risk factors, and three or more risk factors, respectively. After multivariate analysis, the number of risk factors and lymphatic invasion were significant prognostic factors. Conclusion: PORT may be an adequate adjuvant therapy for OSCC patients with one or two risk factors of recurrence. The presence of multiple risk factors and lymphatic invasion correlated with poor prognosis, and more aggressive treatment may need to be considered.

  20. What does germane load mean? An empirical contribution to the cognitive load theory

    Directory of Open Access Journals (Sweden)

    Nicolas eDebue

    2014-10-01

    Full Text Available While over the last decades, much attention has been paid to the mental workload in the field of human computer interactions, there is still a lack of consensus concerning the factors that generate it as well as the measurement methods that could reflect workload variations. Based on the multifactorial Cognitive Load Theory, our study aims to provide some food for thought about the subjective and objective measurement that can be used to disentangle the intrinsic, extraneous and germane load. The purpose is to provide insight into the way cognitive load can explain how users’ cognitive resources are allocated in the use of hypermedia, such as an online newspaper. A two-phase experiment has been conducted on the information retention from online news stories. Phase 1 (92 participants examined the influence of multimedia content on performance as well as the relationships between cognitive loads and cognitive absorption. In Phase 2 (36 participants, eye-tracking data were collected in order to provide reliable and objective measures. Results confirmed that performance in information retention was impacted by the presence of multimedia content such as animations and pictures. The higher number of fixations on these animations suggests that users’ attention could have been attracted by them. Results showed the expected opposite relationships between Germane and Extraneous Load, a positive association between GL and cognitive absorption and a nonlinear association between Intrinsic and Germane Load. The trends based on eye-tracking data analysis provide some interesting findings about the relationships between longer fixations, shorter saccades and cognitive load. Some issues are raised about the respective contribution of mean pupil diameter and Index of Cognitive Activity.

  1. Load Estimation from Natural input Modal Analysis

    DEFF Research Database (Denmark)

    Aenlle, Manuel López; Brincker, Rune; Canteli, Alfonso Fernández

    2005-01-01

    One application of Natural Input Modal Analysis consists in estimating the unknown load acting on structures such as wind loads, wave loads, traffic loads, etc. In this paper, a procedure to determine loading from a truncated modal model, as well as the results of an experimental testing programme...... estimation. In the experimental program a small structure subjected to vibration was used to estimate the loading from the measurements and the experimental modal space. The modal parameters were estimated by Natural Input Modal Analysis and the scaling factors of the mode shapes obtained by the mass change...

  2. Load testing circuit

    DEFF Research Database (Denmark)

    2009-01-01

    A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

  3. Some pollinators are more equal than others: Factors influencing pollen loads and seed set capacity of two actively and passively pollinating fig wasps

    Science.gov (United States)

    Kjellberg, Finn; Suleman, Nazia; Raja, Shazia; Tayou, Abelouahad; Hossaert-McKey, Martine; Compton, Stephen G.

    2014-05-01

    The nursery pollination system of fig trees (Ficus) results in the plants providing resources for pollinator fig wasp larvae as part of their male reproductive investment, with selection determining relative investment into pollinating wasps and the pollen they carry. The small size of Ficus pollen suggests that the quantities of pollen transported by individual wasps often limits male reproductive success. We assessed variation in fig wasp pollen loads and its influence on seed production in actively pollinated (Ficus montana) and passively pollinated (Ficus carica) dioecious fig trees.

  4. Electronic Informational and Educational Environment as a Factor of Competence-Oriented Higher Pedagogical Education in the Sphere of Health, Safety and Environment

    Science.gov (United States)

    Kamerilova, Galina S.; Kartavykh, Marina A.; Ageeva, Elena L.; Veryaskina, Marina A.; Ruban, Elena M.

    2016-01-01

    The authors consider the question of computerisation in health, safety and environment teachers' training in the context of the general approaches and requirements of the Federal National Standard of Higher Education, which is realised through designing of electronic informational and educational environment. The researchers argue indispensability…

  5. The Transformation of the Motivation Sphere as a Factor in the Formation of the Professional and Personality Qualities of Graduates of Higher Educational Institutions

    Science.gov (United States)

    Shashkova, S. N.

    2010-01-01

    The problems of the formation of the professional and personality qualities of graduates of higher educational institutions became especially relevant during the period in which Russia was making the transition to the new economic course of action, the system of market relations. However, the roots of these problems are to be found in the…

  6. Factors Affecting the State Anxiety Level of Higher Education Students in Macau: The Impact of Trait Anxiety and Self-Esteem

    Science.gov (United States)

    Cheung, Hoi-Yan

    2006-01-01

    The aim of this study is to find out the levels of anxiety of 589 day- and night-class students in higher education in Macau two weeks before the final examination period. The Chinese version of the 40-item Spielberger's State-Trait Anxiety Inventory (Spielberger, Gorsuch & Lusherier, 1970) was applied in this study. The two anxiety scales are…

  7. Remapping the "Landscape of Choice": Patterns of Social Class Convergence in the Psycho-Social Factors Shaping the Higher Education Choice Process

    Science.gov (United States)

    Kettley, Nigel Charles; Whitehead, Joan M.

    2012-01-01

    This paper provides a critique of recent Bourdieusian research into the higher education (HE) choice process. Specifically, Ball et al. (2002) maintain that class-related differences in students' psycho-social dispositions in Years 12 and 13, the "landscape of choice", shape their intentions or "decisions" to participate in HE and their selection…

  8. Perceived Factors Influencing High School Student Participation in an Integrated Statewide Dual Credit Program: An Examination of Program Success and Student Higher Education Selection Decisions

    Science.gov (United States)

    Touchstone, Allison J. L.

    2010-01-01

    Dual credit programs have become increasingly popular with 71% U.S. public high schools offering dual credit courses in 2002-2003. As this popularity has grown, so have concerns regarding academic rigor, course quality, parity with college courses, and effects on higher education. Determining actual dual credit course equivalent in higher…

  9. Loads and loads and loads: The influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Directory of Open Access Journals (Sweden)

    Beat eMeier

    2015-06-01

    Full Text Available In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of prospective load on costs in the ongoing task for categorical targets (Experiment 2, but not for specific targets (Experiment 1. Retrospective load and ongoing task load both affected remembering the retrospective component of the prospective memory task. We suggest that prospective load can enhance costs in the ongoing task due to additional monitoring requirements. Retrospective load and ongoing task load seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  10. Higher Expression of Epidermal Growth Factor Receptor Is Associated with Extracellular Matrix Metalloprotease Inducer in Colorectal Adenocarcinoma: Tissue Microarray Analysis of Immunostaining Score with Clinicopathological Parameters

    Directory of Open Access Journals (Sweden)

    Jong-Shiaw Jin

    2006-01-01

    Full Text Available Aim: Extracellular matrix metalloprotease inducer (EMMPRIN expression was demonstrated in several cancers, but its expression profile in colorectal cancers remains unclear. Epidermal growth factor receptor (EGFR was reported to regulate EMMPRIN expression in human epithelial cancers. Our purpose was to determine EMMPRIN expression and its relationship with EGFR in colorectal cancers.

  11. Socio-Economic, Environmental and Personal Factors in the Choice of Country and Higher Education Institution for Studying Abroad among International Students in Malaysia

    Science.gov (United States)

    Singh, Manjet Kaur Mehar

    2016-01-01

    Purpose: The purpose of this paper is to understand the pull factors that influenced international students' choice of country and institution for their Master's education. Design/Methodology/ Approach: This qualitative study relied upon focus group interviews with 70 international students registered in taught Master programmes at a higher…

  12. Plasma insulin-like growth factor I levels are higher in depressive and anxiety disorders, but lower in antidepressant medication users

    NARCIS (Netherlands)

    Bot, Mariska; Milaneschi, Yuri; Penninx, Brenda W J H; Drent, Madeleine L

    It has been postulated that many peripheral and (neuro)biological systems are involved in psychiatric disorders such as depression. Some studies found associations of depression and antidepressant treatment with insulin-like growth factor 1 (IGF-I) - a pleiotropic hormone affecting neuronal growth,

  13. Factors influencing maternal decision-making for the infant sleep environment in families at higher risk of SIDS:a qualitative study

    OpenAIRE

    Pease, Anna; Ingram, Jenny; Blair, Pete; Fleming, Peter

    2017-01-01

    Objective: Qualitative interviews with mothers of babies at higher risk of sudden infant death syndrome (SIDS) were carried out to understand their views and decision-making process on the infant sleep environment and safe sleep messages.Design and setting: Twenty semi-structured interviews were conducted between February and November 2014 in deprived areas of Bristol, UK. Mothers were asked about their decision-making for the infant sleep environment and safe sleep messages including infant ...

  14. Transient beam loading in the ALS harmonic RF system

    International Nuclear Information System (INIS)

    Byrd, J.; De Santis, S.; Georgsson, M.; Stover, G.; Fox, J.; Prabhakar, S.; Teytelman, D.

    2000-01-01

    We report on the commissioning of a higher harmonic radiofrequency system at the Advanced Light Source, designed to improve the beam lifetime. We have achieved an increase above a factor of two in our best results up to now. Transient beam loading of the harmonic cavities, due to the unequal fill patterns, creates the greatest limitation on lifetime improvement. We also describe several interesting effects on the operation of the longitudinal and transverse multibunch feedback system

  15. Low cognitive load strengthens distractor interference while high load attenuates when cognitive load and distractor possess similar visual characteristics.

    Science.gov (United States)

    Minamoto, Takehiro; Shipstead, Zach; Osaka, Naoyuki; Engle, Randall W

    2015-07-01

    Studies on visual cognitive load have reported inconsistent effects of distractor interference when distractors have visual characteristic that are similar to the cognitive load. Some studies have shown that the cognitive load enhances distractor interference, while others reported an attenuating effect. We attribute these inconsistencies to the amount of cognitive load that a person is required to maintain. Lower amounts of cognitive load increase distractor interference by orienting attention toward visually similar distractors. Higher amounts of cognitive load attenuate distractor interference by depleting attentional resources needed to process distractors. In the present study, cognitive load consisted of faces (Experiments 1-3) or scenes (Experiment 2). Participants performed a selective attention task in which they ignored face distractors while judging a color of a target dot presented nearby, under differing amounts of load. Across these experiments distractor interference was greater in the low-load condition and smaller in the high-load condition when the content of the cognitive load had similar visual characteristic to the distractors. We also found that when a series of judgments needed to be made, the effect was apparent for the first trial but not for the second. We further tested an involvement of working memory capacity (WMC) in the load effect (Experiment 3). Interestingly, both high and low WMC groups received an equivalent effect of the cognitive load in the first distractor, suggesting these effects are fairly automatic.

  16. Cognitive Load of Learner Control: Extraneous or Germane Load?

    Directory of Open Access Journals (Sweden)

    Mieke Vandewaetere

    2013-01-01

    Full Text Available Computer-based learning environments become more tailored when learners can exert control over one or more parts of the learning process. Learner control (LC demands additional efforts of learners because, in addition to learning, they also have to monitor that learning. As a consequence, LC may cause additional cognitive load and even cognitive overload. The central question in this study is what type of cognitive load is induced by LC and whether the experienced load is related to learning outcomes. For this study, half of the students had control over task selection, while the other half had not. Within each condition, students were assigned to a single treatment, with the primary task to solely focus on the learning content, and a dual treatment, comprising a primary task and a secondary task. The results indicate that LC did not impose higher cognitive load as measured by secondary task scores and mental effort ratings.

  17. Low-back loading in lifting two loads beside the body compared to lifting one load in front of the body

    NARCIS (Netherlands)

    Faber, G.S.; Kingma, I.; Bakker, A.J.; van Dieen, J.H.

    2009-01-01

    Low-back load during manual lifting is considered an important risk factor for the occurrence of low-back pain. Splitting a load, so it can be lifted beside the body (one load in each hand), instead of in front of the body, can be expected to reduce low-back load. Twelve healthy young men lifted 10

  18. Radiosensitivity of higher plants

    International Nuclear Information System (INIS)

    Feng Zhijie

    1992-11-01

    The general views on radiosensitivity of higher plants have been introduced from published references. The radiosensitivity varies with species, varieties and organs or tissues. The main factors of determining the radiosensitivity in different species are nucleus volume, chromosome volume, DNA content and endogenous compounds. The self-repair ability of DNA damage and chemical group of biological molecules, such as -SH thiohydroxy of proteins, are main factors to determine the radiosensitivity in different varieties. The moisture, oxygen, temperature radiosensitizer and protector are important external factors for radiosensitivity. Both the multiple target model and Chadwick-Leenhouts model are ideal mathematical models for describing the radiosensitivity of higher plants and the latter has more clear significance in biology

  19. Prevalence and factors associated with a higher risk of neck and back pain among permanent wheelchair users: a cross-sectional study.

    Science.gov (United States)

    Kovacs, Francisco M; Seco, Jesús; Royuela, Ana; Barriga, Andrés; Zamora, Javier

    2018-04-01

    Cross-sectional study. To determine the prevalence of, and factors associated with, spinal pain among wheelchair users. Four Spanish hospitals specialized in providing care for wheelchair users. Persons who had used a wheelchair for a median (IRQ) of 10 (5;19) years, 27% of them due to reasons other than spinal cord injury, were recruited consecutively (n = 750). Data on 43 demographic, psychosocial, ergonomic, and clinical variables were collected, and analyzed. Main outcome measures were: point prevalence of neck (NP), thoracic (TP), low back pain (LBP), and pain at any spinal level (PASL); and factors associated with them. Point prevalence was 56% for NP, 54% for TP, 45% for LBP, and 76% for PSAL. PASL was associated with a lower quality of life (OR (95% CI) 0.91 (0.86; 0.97)). Multivariable regression models showed that the main factors associated with significant pain (≥1.5 VAS points) were: (a) For NP: cervical spinal injury and wheelchair seat cushion thickness, (b) For TP: thoracic spinal injury and sagittal index, (c) For LBP: thoracic or lumbar spinal injury, with some sensitivity remaining, (d) For PASL: being female, living alone, and using a non-power wheelchair. Discrimination (AUC) of these models ranged between 0.638 and 0.818. p-values in the Hosmer-Lemeshow test ranged between 0.420 and 0.701. Prevalence of spinal pain among wheelchair users is high. It is associated with a lower quality of life. Future studies should assess whether using a power wheelchair affects PASL, and if the thickness of seat cushion affects NP. Spanish Back Pain Research Network.

  20. Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores

    Directory of Open Access Journals (Sweden)

    Mortezavi Ashkan

    2010-06-01

    Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

  1. Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

    International Nuclear Information System (INIS)

    Ikenberg, Kristian; Behnke, Silvia; Gerhardt, Josefine; Mortezavi, Ashkan; Wild, Peter; Hofstädter, Ferdinand; Burger, Maximilian; Moch, Holger; Kristiansen, Glen; Fritzsche, Florian R; Zuerrer-Haerdi, Ursina; Hofmann, Irina; Hermanns, Thomas; Seifert, Helge; Müntener, Michael; Provenzano, Maurizio; Sulser, Tullio

    2010-01-01

    The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed

  2. Socially disadvantaged city districts show a higher incidence of acute ST-elevation myocardial infarctions with elevated cardiovascular risk factors and worse prognosis.

    Science.gov (United States)

    Schmucker, J; Seide, S; Wienbergen, H; Fiehn, E; Stehmeier, J; Günther, K; Ahrens, W; Hambrecht, R; Pohlabeln, H; Fach, A

    2017-09-22

    The importance of socioeconomic status (SES) for coronary heart disease (CHD)-morbidity is subject of ongoing scientific investigations. This study was to explore the association between SES in different city-districts of Bremen/Germany and incidence, severity, treatment modalities and prognosis for patients with ST-elevation myocardial infarctions (STEMI). Since 2006 all STEMI-patients from the metropolitan area of Bremen are documented in the Bremen STEMI-registry. Utilizing postal codes of their home address they were assigned to four groups in accordance to the Bremen social deprivation-index (G1: high, G2: intermediate high, G3: intermediate low, G4: low socioeconomic status). Three thousand four hundred sixty-two consecutive patients with STEMI admitted between 2006 and 2015 entered analysis. City areas with low SES showed higher adjusted STEMI-incidence-rates (IR-ratio 1.56, G4 vs. G1). This elevation could be observed in both sexes (women IRR 1.63, men IRR 1.54) and was most prominent in inhabitants  3000 U/l, OR 1.95, 95% CI 1.4-2.8) and severe impairment of LV-function post-STEMI (OR 2.0, 95% CI 1.2-3.4). Long term follow-up revealed that lower SES was associated with higher major adverse cardiac or cerebrovascular event (MACCE)-rates after 5 years: G1 30.8%, G2 35.7%, G3 36.0%, G4 41.1%, p (for trend) = 0.02. This worse prognosis could especially be shown for young STEMI-patients (<50 yrs. of age) 5-yr. mortality-rates(G4 vs. G1) 18.4 vs. 3.1%, p = 0.03 and 5-year-MACCE-rates (G4 vs. G1) 32 vs. 6.3%, p = 0.02. This registry-data confirms the negative association of low socioeconomic status and STEMI-incidence, with higher rates of smoking and obesity, more extensive infarctions and worse prognosis for the socio-economically deprived.

  3. Platelet activating factor-acylhydrolase (PAF-ase) activity is higher in serum of men than women and is related to levels of low density lipoprotein (LDL)

    International Nuclear Information System (INIS)

    Farr, R.S.; Howell, S.E.; Wardlow, M.L.

    1986-01-01

    PAF-ase is a specific serum enzyme that inactivates PAF by hydrolyzing acetate from the sn-2 position of the glycerol backbone. A reproducible PAF-ase activity assay was developed. A unit is based on the amount of serum required to release 3.61 +/- 0.042 pm 3 H-acetate from 10 pm 3 H-labeled PAF after incubation for 1 hr at 37 0 C. Assays on two single reference serums repeated 7 days were 0.63 +/- 0.013 U and 1.33 +/- 0.031 U. Serum from 20 normal men and 20 normal premenopausal women had significantly different (p = <0.001) levels of 1.32 +/- 0.072 U and 0.97 +/- 0.051 U respectively. They previously reported that PAF-ase is associated with B-lipoprotein. Therefore, total cholesterol (TC), LDL and high density lipoproteins (HDL) were determined on these 40 serums. Regression analysis revealed PAF-ase units were correlated with LDL (r = 0.740; p = < 0.001) and, parenthetically, with the TC (r = 0.620; p = < 0.001) but not with HDL. These correlations were similar for men and women. Thus, serum PAF-ase was partially controlled by serum LDL levels and the higher PAF-ase levels in serum from men were due in part to higher (p = < 0.01) LDL levels in men (147.6 +/- 6.9 mg/dl) as contrasted to women (119.0 +/- 7.6 mg/dl). PAF is a potent inflammatory, bronchoconstrictive and hypotensive agent. These data indicate that sex and serum LDL levels of subjects must be considered during future studies of the role of PAF vs PAF-ase in different disease states

  4. Distribution load estimation (DLE)

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A; Lehtonen, M [VTT Energy, Espoo (Finland)

    1998-08-01

    The load research has produced customer class load models to convert the customers` annual energy consumption to hourly load values. The reliability of load models applied from a nation-wide sample is limited in any specific network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to find improvements to the load models or, in general, improvements to the load estimates. In Distribution Load Estimation (DLE) the measurements from the network are utilized to improve the customer class load models. The results of DLE will be new load models that better correspond to the loading of the distribution network but are still close to the original load models obtained by load research. The principal data flow of DLE is presented

  5. Effect of plants in constructed wetlands for organic carbon and nutrient removal: a review of experimental factors contributing to higher impact and suggestions for future guidelines.

    Science.gov (United States)

    Jesus, João M; Danko, Anthony S; Fiúza, António; Borges, Maria-Teresa

    2018-02-01

    Constructed wetland is a proven technology for water pollution removal, but process mechanisms and their respective contribution are not fully understood. The present review details the effect of plants on removal efficiency of constructed wetlands by focusing on literature that includes experiments with unplanted controls for organic carbon and nutrient (N and P) removal. The contribution of plant direct uptake is also assessed. Although it was found that several studies, mostly at laboratory or pilot scales, showed no statistical differences between planted and unplanted controls, some factors were found that help maximize the effect of plants. This study intends to contribute to a better understanding of the significance of the effect of plants in a constructed wetland, as well as to suggest a set of experimental guidelines in this field.

  6. An analysis of representative heating load lines for residential HSPF ratings

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C. Keith [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shen, Bo [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shrestha, Som S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    This report describes an analysis to investigate representative heating loads for single-family detached homes using current EnergyPlus simulations (DOE 2014a). Hourly delivered load results are used to determine binned load lines using US Department of Energy (DOE) residential prototype building models (DOE 2014b) developed by Pacific Northwest National Laboratory (PNNL). The selected residential single-family prototype buildings are based on the 2006 International Energy Conservation Code (IECC 2006) in the DOE climate regions. The resulting load lines are compared with the American National Standards Institute (ANSI)/Air-Conditioning, Heating, and Refrigeration Institute (AHRI) Standard 210/240 (AHRI 2008) minimum and maximum design heating requirement (DHR) load lines of the heating seasonal performance factor (HSPF) ratings procedure for each region. The results indicate that a heating load line closer to the maximum DHR load line, and with a lower zero load ambient temperature, is more representative of heating loads predicted for EnergyPlus prototype residential buildings than the minimum DHR load line presently used to determine HSPF ratings. An alternative heating load line equation was developed and compared to binned load lines obtained from the EnergyPlus simulation results. The effect on HSPF of the alternative heating load line was evaluated for single-speed and two-capacity heat pumps, and an average HSPF reduction of 16% was found. The alternative heating load line relationship is tied to the rated cooling capacity of the heat pump based on EnergyPlus autosizing, which is more representative of the house load characteristics than the rated heating capacity. The alternative heating load line equation was found to be independent of climate for the six DOE climate regions investigated, provided an adjustable zero load ambient temperature is used. For Region IV, the default DOE climate region used for HSPF ratings, the higher load line results in an ~28

  7. Chloride concentrations, loads, and yields in four watersheds along Interstate 95, southeastern Connecticut, 2008-11: factors that affect peak chloride concentrations during winter storms

    Science.gov (United States)

    Brown, Craig J.; Mullaney, John R.; Morrison, Jonathan; Martin, Joseph W.; Trombley, Thomas J.

    2015-07-01

    Chloride (Cl-) concentrations and loads and other water chemistry characteristics were assessed to evaluate potential effects of road-deicer applications on streamwater quality in four watersheds along Interstate 95 (I–95) in southeastern Connecticut from November 1, 2008, through September 30, 2011. Streamflow and water quality were studied in the Four Mile River, Oil Mill Brook, Stony Brook, and Jordan Brook watersheds, where developed land ranged from 9 to 32 percent. Water-quality samples were collected and specific conductance was measured continuously at paired water-quality monitoring sites, upstream and downstream from I–95. Specific conductance values were related to Cl- concentrations to assist in determining the effects of road-deicing operations on the levels of Cl-in the streams. Streamflow and water-quality data were compared with weather data and with the timing, amount, and composition of deicers applied to State highways. Grab samples were collected during winter stormwater-runoff events, such as winter storms or periods of rain or warm temperatures in which melting takes place. Grab samples were also collected periodically during the spring and summer and during base-flow conditions.

  8. Distribution load estimation - DLE

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A. [VTT Energy, Espoo (Finland)

    1996-12-31

    The load research project has produced statistical information in the form of load models to convert the figures of annual energy consumption to hourly load values. The reliability of load models is limited to a certain network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to make improvements in the load models. Distribution load estimation (DLE) is the method developed here to improve load estimates from the load models. The method is also quite cheap to apply as it utilises information that is already available in SCADA systems

  9. Distribution load estimation - DLE

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A [VTT Energy, Espoo (Finland)

    1997-12-31

    The load research project has produced statistical information in the form of load models to convert the figures of annual energy consumption to hourly load values. The reliability of load models is limited to a certain network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to make improvements in the load models. Distribution load estimation (DLE) is the method developed here to improve load estimates from the load models. The method is also quite cheap to apply as it utilises information that is already available in SCADA systems

  10. Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.

    Science.gov (United States)

    Vargas-Muñiz, Jose M; Juvvadi, Praveen R; Steinbach, William J

    2016-09-01

    Septins are a conserved family of GTP-binding proteins that are distributed across different lineages of the eukaryotes, with the exception of plants. Septins perform a myriad of functions in fungal cells, ranging from controlling morphogenetic events to contributing to host tissue invasion and virulence. One key attribute of the septins is their ability to assemble into heterooligomeric complexes that organizse into higher order structures. In addition to the established role of septins in the model budding yeast, Saccharomyces cerevisiae, their importance in other fungi recently emerges. While newer roles for septins are being uncovered in these fungi, the mechanism of how septins assemble into a complex and their regulation is only beginning to be comprehended. In this review, we summarize recent findings on the role of septins in different fungi and focus on how the septin complexes of different fungi are organized in vitro and in vivo. Furthermore, we discuss on how phosphorylation/dephosphorylation can serve as an important mechanism of septin complex assembly and regulation.

  11. Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes.

    Science.gov (United States)

    Crepin, Thibaut; Shalak, Vyacheslav F; Yaremchuk, Anna D; Vlasenko, Dmytro O; McCarthy, Andrew; Negrutskii, Boris S; Tukalo, Michail A; El'skaya, Anna V

    2014-11-10

    Eukaryotic elongation factor eEF1A transits between the GTP- and GDP-bound conformations during the ribosomal polypeptide chain elongation. eEF1A*GTP establishes a complex with the aminoacyl-tRNA in the A site of the 80S ribosome. Correct codon-anticodon recognition triggers GTP hydrolysis, with subsequent dissociation of eEF1A*GDP from the ribosome. The structures of both the 'GTP'- and 'GDP'-bound conformations of eEF1A are unknown. Thus, the eEF1A-related ribosomal mechanisms were anticipated only by analogy with the bacterial homolog EF-Tu. Here, we report the first crystal structure of the mammalian eEF1A2*GDP complex which indicates major differences in the organization of the nucleotide-binding domain and intramolecular movements of eEF1A compared to EF-Tu. Our results explain the nucleotide exchange mechanism in the mammalian eEF1A and suggest that the first step of eEF1A*GDP dissociation from the 80S ribosome is the rotation of the nucleotide-binding domain observed after GTP hydrolysis. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Does the adolescent patellar tendon respond to 5 days of cumulative load during a volleyball tournament?

    NARCIS (Netherlands)

    van Ark, M.; Docking, S.I.; van den Akker-Scheek, I.; Rudavsky, A.; Rio, E.; Zwerver, J.; Cook, J.L.

    Patellar tendinopathy (jumper's knee) has a high prevalence in jumping athletes. Excessive load on the patellar tendon through high volumes of training and competition is an important risk factor. Structural changes in the tendon are related to a higher risk of developing patellar tendinopathy. The

  13. Probability Based Evaluation of Vehicular Bridge Load using Weigh-in-Motion Data

    OpenAIRE

    Widi Nugraha; Indra Djati Sidi

    2016-01-01

    Load and Resistance Factored Design (LRFD) method for designing bridge in Indonesia have been implemented for more than 25 years. LRFD method treating loads and strengths variables as random variables with specific safety factors for different loads and strengths variables type. The nominal loads, load factors, reduction factors, and other criteria for bridge design code can be determined to meet the reliability criteria. Statistical data of weigh-in-motion (WIM) vehicular loads measurement i...

  14. +Gz load and executive functions.

    Science.gov (United States)

    Biernacki, Marcin P; Tarnowski, Adam; Lengsfeld, Kamila; Lewkowicz, Rafał; Kowalczuk, Krzysztof; Dereń, Miroslaw

    2013-05-01

    Pilots are constantly exposed to a number of environmental factors, which include +Gz load. Physiological changes evoked by +Gz stimuli have already been well investigated in aviation medicine. However, the influence of +Gz stimulation on executive functions in pilots has not yet been thoroughly explored. There were 20 pilot cadets between the ages of 19 and 22 yr who volunteered to participate in the experiment. The subjects were divided into two groups: the G-load group, which was exposed to accelerations in the centrifuge, and the control group, which did not undergo this stimulation. Executive functions were assessed by means of the Schulte tables and the Rey-Osterrieth complex figure test. +Gz load exposure significantly improved attention switching. This relationship was valid for performance speed (M = 268.09 s in the pretest in the G-load group; M = 228.09 s in the posttest in the G-load group) and for the cumulative time of mistakes (M = 26.73 s in the pretest in the G-load group; M = 12 s in the posttest in the G-load group), whereas reproduction of visuospatial stimuli from memory deteriorated significantly under the influence of +Gz stimulation (M = 17.18 points in the posttest in the G-load group; M = 28.18 points in the posttest in the control group). These results suggest that the impact of +Gz load is not homogenous and unidirectional, since it improves attention switching but visuospatial working memory decreases under its influence. These aspects are particularly important for understanding the mechanisms responsible for maintaining situational awareness during the flight.

  15. Higher 25-hydroxyvitamin D levels are associated with greater odds of remission with anti-tumour necrosis factor-α medications among patients with inflammatory bowel diseases.

    Science.gov (United States)

    Winter, R W; Collins, E; Cao, B; Carrellas, M; Crowell, A M; Korzenik, J R

    2017-03-01

    Vitamin D has been linked to disease activity among patients with inflammatory bowel diseases (IBD). Prior investigation has also suggested that vitamin D levels may affect duration of therapy with anti-tumour necrosis factor-α (anti-TNF-α) medications among patients with IBD. To evaluate the relationship between vitamin D levels and odds of reaching remission while on an anti-TNF-α medication. A total of 521 IBD patients enrolled in the Brigham and Women's IBD Centre database were eligible for inclusion. Patients treated with anti-TNF-α therapy who had vitamin D levels drawn within 6 months prior or 2 weeks after initiation of anti-TNF-α medication and who had reported remission status at 3 months were included. A logistic regression model adjusting for age, gender, IBD diagnosis, anti-TNF-α medication (infliximab vs. adalimumab) and first or subsequent anti-TNF-α medication was used to identify the effect of vitamin D level on initial response to anti-TNF-α therapy. A total of 173 patients were included in the final analysis. On logistic regression, patients with normal vitamin D levels n = 122 at the time of anti-TNF-α medication initiation had a 2.64 increased odds of remission at 3 months compared to patients with low vitamin D levels n = 51 when controlling for age, gender, diagnosis, type of anti-TNF-α medication and first or subsequent anti-TNF-α medication (OR = 2.64, 95% CI = 1.31-5.32, P = 0.0067). These findings suggest that vitamin D levels may influence initial response to anti-TNF-α medication and that low vitamin D levels may pre-dispose patients to decreased odds of remission. © 2017 John Wiley & Sons Ltd.

  16. Higher Incidence of Stroke on the Last Day of the Month in Hungary-a Role for Psychosocial Factors and Financial Insecurity?

    Science.gov (United States)

    Folyovich, András; Biczó, Dávid; Bajnok, Anna; Bessenyei, Dávid; Kis, Ibolya; Gimesi-Országh, Judit; Béres-Molnár, Anna K; Toldi, Gergely

    2016-05-01

    The seasonal cumulation of acute ischemic stroke events is a well-known phenomenon. Critical days are determined by both biological and psychosocial factors. We hypothesized that the financial stability of those with a monthly income living in an economically unpredictable environment rises upon the arrival of their salary and decreases in the preceding days, leading to anxiety and existential insecurity, which may increase the incidence of acute ischemic stroke. We assessed the daily average number of thrombolytic treatments due to acute ischemic stroke in Hungary between December 1, 2005, and November 30, 2013, calculating the ratio of thrombolytic treatments on the last day of the month (irrespectively whether it was the 28th-31st days) to thrombolytic treatments on the other days, and determined 95% confidence intervals. In this period, 7880 thrombolytic treatments were performed nationwide (2.70/day), out of which 1867 occurred on the last day of the month (19.45/day). If the 28th, 29th, or 30th was not the last day of the month, 15.8, 20.6, and 22 times less thrombolytic treatments, respectively, were performed than on the last day of that month. We propose that financial insecurity on the days prior to the receipt of a salary might play a role in the elevation of stroke incidence observed on the last day of the month in Hungary. Further analysis of this phenomenon and its psychosocial effects is needed to adequately allocate healthcare resources and to take preventive measures in the high-risk population. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  17. Reliability analysis of RC containment structures under combined loads

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Kagami, S.

    1984-01-01

    This paper discusses a reliability analysis method and load combination design criteria for reinforced concrete containment structures under combined loads. The probability based reliability analysis method is briefly described. For load combination design criteria, derivations of the load factors for accidental pressure due to a design basis accident and safe shutdown earthquake (SSE) for three target limit state probabilities are presented

  18. Effect of Water Vapor Pressure on Fatigue Crack Growth in Al-Zn-Cu-Mg Alloy Over Wide-Range Stress Intensity Factor Loading

    Science.gov (United States)

    2014-05-07

    pressure and frequency on fatigue behaviour in 7017-T651 aluminium alloy plate, Acta Mater, 45 (1997) 281-293. [30) N.J.H. Holroyd, D. Hardie, Factors... aluminium alloys , Acta Mater, 45 (1997) 3855-3870. [33) S. Lynch, Hydrogen embrittlement phenomena and mechanisms, Corros Rev, 30 (2012) 105-123. [34...role of environmental exposure in the fatigue behaviour of an aluminium alloy , Corros Sci, 39 (1997) 2117-2141. [39) R.S. Piascik, R.P. Gangloff

  19. Voltage-Sharing Converter to Supply Single-Phase Asymmetrical Four-Level Diode-Clamped Inverter With High Power Factor Loads

    DEFF Research Database (Denmark)

    Boora, Arash A.; Nami, Alireza; Zare, Firuz

    2010-01-01

    The output voltage quality of some of the single-phase multilevel inverters can be improved when their dc-link voltages are regulated asymmetrically. Symmetrical and asymmetrical multilevel diode-clamped inverters have the problem of dc-link capacitor voltage balancing, especially when power factor...... that the proposed combination of introduced multioutput dc–dc converter and single-phase ADCI is a good candidate for power conversion in residential photovoltaic (PV) utilization....

  20. electrical load survey electrical load survey and forecast

    African Journals Online (AJOL)

    eobe

    scattered nature of the area and low load factor. In this ... employment and allow decentralized production of the ... and viable concept from energy production and .... VII Yr. ×. kWh. VIII Yr. ×. kWh. IX Yr. ×. kWh. X Yr. ×. kWh. 1. Residential. 147.

  1. C.A.P. Follow up of the transients and use factors for the most loaded elements of the primary circuit

    International Nuclear Information System (INIS)

    Gaouditz, N.; Chabre, A.; Lecourtois, Y.

    1979-01-01

    The control authorities of all countries lay down increasingly stricter rules for the definition, fabrication and maintenance of nuclear capacities under pressure. In particular the operator has to ensure that the apparatus does not have to withstand stresses greater in number, intensity and rapidity than those allowed for in the project. In other words he must workout, classify and combine the various transients supported by the apparatus throughout its lifetime. The account method enables the actual transients to be classified in relation to the reference transients and their cumulated number followed periodically. This number can then be used to find the use factor which, when extrapolated to the lifetime of the element concerned, must be lower or equal to the use factor provided in the design always less than one. In point of fact, although simple in formulation, this becomes fairly complicated in application for a particular point of the capacity may be subjected to a great number of various types of stresses, each one leading to a particular damage of which the use factors, f, will be cumulated in accordance with the rules stipulated in the ASME Code, section III [fr

  2. Limit load assessment of centre cracked plates under biaxial loading

    International Nuclear Information System (INIS)

    Meek, C.; Ainsworth, R.A.

    2015-01-01

    Fitness-for-service of equipment and components containing defects is generally assessed using procedures such as BS 7910, API 579 and R6. There is currently little detailed advice in these procedures on the effects of biaxial and triaxial loading on fracture. This poster shows some theoretical bounding solutions of the plastic limit load for centre cracked plates under a variety of biaxial loading ratios and compares the estimates with those found by numerical methods using finite element (FE) analysis using Abacus CAE modelling software. The limit load of a structure is the maximum load that it can carry before plastic collapse occurs; this is often when the plastic zone has become large enough to spread from the crack tip to a remote boundary. For an elastic-perfectly plastic material, the irreversible deformation will continue at stresses no higher than the yield stress. The model for these limit load solutions is a bi-axially loaded plate of width 2W and height 2H, a centre crack of width 2a, acted on by remotely applied uniform stresses σ 2 perpendicular to the crack and Bσ 2 parallel to the crack, where B is the biaxial loading ratio, it means the ratio of the parallel to the perpendicular stress. A quarter plate of an elastic-perfectly plastic material has been modelled. The results show that an exact solution has been found for negative and low positive values of B. For B > 1, the lower bound solution is conservative for all values of a/W and B

  3. Drug Loading of Mesoporous Silicon

    Science.gov (United States)

    Moffitt, Anne; Coffer, Jeff; Wang, Mengjia

    2011-03-01

    The nanostructuring of crystalline solids with low aqueous solubilities by their incorporation into mesoporous host materials is one route to improve the bioavailability of such solids. Earlier studies suggest that mesoporous Si (PSi), with pore widths in the range of 5-50 nm, is a candidate for such an approach. In this presentation, we describe efforts to load curcumin into free-standing microparticles of PSi. Curcumin is a compound extracted from turmeric root, which is an ingredient of curry. Curucmin has shown activity against selected cancer cell lines, bacteria, and other medical conditions. However, curcumin has a very low bioavailability due to its extremely low water solubility (0.6 μ g/mL). Incorporation of curcumin was achieved by straightforward loading of the molten solid at 185circ; C. Loading experiments were performed using PSi particles of two different size ranges, 45-75 μ m and 150-250 μ m. Longer loading times and ratio of curcumin to PSi leads to a higher percentage of loaded curcumin in both PSi particle sizes (as determined by weight difference). The extent of curcumin crystallinity was assessed by x-ray diffraction (XRD). The solubility and release kinetics of loaded curcumin from the PSi was determined by extraction into water at 37circ; C, with analysis using UV-VIS spectrometry. NSF-REU and TCU.

  4. Effect of vibration loading on the fatigue life of part-through notched pipe

    International Nuclear Information System (INIS)

    Mittal, Rahul; Singh, P.K.; Pukazhendi, D.M.; Bhasin, V.; Vaze, K.K.; Ghosh, A.K.

    2011-01-01

    A systematic experimental and analytical study has been carried out to investigate the effect of vibration loading on the fatigue life of the piping components. Three Point bend (TPB) specimens machined from the actual pipe have been used for the evaluation of Paris constants by carrying out the experiments under vibration + cyclic and cyclic loading as per the ASTM Standard E647. These constants have been used for the prediction of the fatigue life of the pipe having part-through notch of a/t = 0.25 and aspect ratio (2c/a) of 10. Predicted results have shown the reduction in fatigue life of the notched pipe subjected to vibration + cyclic loading by 50% compared to that of cyclic loading. Predicted results have been validated by carrying out the full-scale pipe (with part-through notch) tests. Notched pipes were subjected to loading conditions such that the initial stress-intensity factor remains same as that of TPB specimen. Experimental results of the full-scale pipe tests under vibration + cyclic loading has shown the reduction in fatigue life by 70% compared to that of cyclic loading. Fractographic examination of the fracture surface of the tested specimens subjected to vibration + cyclic loading have shown higher presence of brittle phases such as martensite (in the form of isolated planar facets) and secondary micro cracks. This could be the reason for the reduction of fatigue life in pipe subjected to vibration + cyclic loading. - Highlights: → Vibration loading affects fatigue crack growth rate. → Crack initiation life depends on crack tip radius. → Crack initiation life depends on the characteristic distance. → Characteristic distance depends on the loading conditions. → Vibration + cyclic load gives lower fatigue life.

  5. Simulation of PV/FC power hybrid system. Change of system capacity with load form factor; Taiyoko hatsuden nenryo denchi hybrid system no simulation. Fuka keijoritsu ni yoru system yoryo no henka

    Energy Technology Data Exchange (ETDEWEB)

    Sekiguchi, N.; Tani, T. [Science University of Tokyo, Tokyo (Japan)

    1997-11-25

    Study is conducted of a photovoltaic/fuel-cell hybrid system whose power storage is a hydrogen storage that uses a hydrogen absorbing alloy. In a simulation in this research, the solar cell conversion efficiency is changed from 15.0% to 21.0% and the fuel cell power conversion efficiency from 40.0% to 50.0%, and the resultant changes in the capacity and operation rate are investigated for each of the devices in the system. The findings follow. A 1.0% change in the solar cell conversion efficiency results in a 4.8kW change in the solar cell capacity and a 1.6-ton change in the hydrogen storage capacity. With a 1.0% change in the fuel cell power conversion efficiency, there is a 14.7kW change in the solar cell capacity and a 5.3-ton change in the hydrogen storage capacity. The fuel cell capacity is not dependent on the solar cell conversion efficiency or fuel cell power conversion efficiency but on the maximum load in each of the load form factors. The rate of occurrence of an operation rate of less than 30% is 54.7% both in DC/DC converter and hydrogen generator, 24.6% in fuel cells, and 16.7% in the DC/DC inverter. 7 refs., 7 figs., 1 tab.

  6. The effect of Fe, Mn, Ni and Pb Load on Soil and its enrichment factor ratios in different soil grain size fractions as an Indicator for soil pollution

    International Nuclear Information System (INIS)

    Rabie, F.H.; Abdel-Sabour, M.F.

    2000-01-01

    An industrial area north of greater Cairo was selected to investigate the impact of intensive industrial activities on soil characteristics and Fe, Mn, Ni and Pb total content. The studied area was divided to six sectors according to its source of irrigation water and/or probability of pollution. Sixteen soil profiles were dug and soil samples were taken, air dried, fractionated to different grain size fractions, then total heavy metals (Fe, Mn, Ni and Pb) were determined using ICP technique. The enrichment factor for each metal for each soil fraction/soil layer was estimated and discussed. The highest EF ratios in the clay fraction was mainly with Pb which indicated the industrial impact on the soil. In case of sand fraction, Mn was the highest always compared to other studied metals. Concerning silt fraction, a varied accumulation of Fe, Mn, and Pb was observed with soil depth and different soil profiles

  7. Quantification of baseline pupillary response and task-evoked pupillary response during constant and incremental task load.

    Science.gov (United States)

    Mosaly, Prithima R; Mazur, Lukasz M; Marks, Lawrence B

    2017-10-01

    The methods employed to quantify the baseline pupil size and task-evoked pupillary response (TEPR) may affect the overall study results. To test this hypothesis, the objective of this study was to assess variability in baseline pupil size and TEPR during two basic working memory tasks: constant load of 3-letters memorisation-recall (10 trials), and incremental load memorisation-recall (two trials of each load level), using two commonly used methods (1) change from trail/load specific baseline, (2) change from constant baseline. Results indicated that there was a significant shift in baseline between the trails for constant load, and between the load levels for incremental load. The TEPR was independent of shifts in baseline using method 1 only for constant load, and method 2 only for higher levels of incremental load condition. These important findings suggest that the assessment of both the baseline and methods to quantify TEPR are critical in ergonomics application, especially in studies with small number of trials per subject per condition. Practitioner Summary: Quantification of TEPR can be affected by shifts in baseline pupil size that are most likely affected by non-cognitive factors when other external factors are kept constant. Therefore, quantification methods employed to compute both baseline and TEPR are critical in understanding the information processing of humans in practical ergonomics settings.

  8. SPEAR 2 RF SYSTEM LOADS

    International Nuclear Information System (INIS)

    2002-01-01

    The design and performance of higher order mode (HOM) dampers for the SPEAR 2 RF system is presented. The SPEAR beam had experienced occasional periods of instability due to transverse oscillations which were driven by HOMs in the RF cavities. A substantial fraction of this RF energy was coupled out of the cavity into the waveguide connecting the cavity to the klystron. This waveguide was modified by adding a stub of smaller cross section, terminated by a ferrite tile load, to the system. Design considerations of the load, and its effect on HOMs and beam stability will be discussed

  9. The impact of cognitive load on reward evaluation.

    Science.gov (United States)

    Krigolson, Olave E; Hassall, Cameron D; Satel, Jason; Klein, Raymond M

    2015-11-19

    The neural systems that afford our ability to evaluate rewards and punishments are impacted by a variety of external factors. Here, we demonstrate that increased cognitive load reduces the functional efficacy of a reward processing system within the human medial-frontal cortex. In our paradigm, two groups of participants used performance feedback to estimate the exact duration of one second while electroencephalographic (EEG) data was recorded. Prior to performing the time estimation task, both groups were instructed to keep their eyes still and avoid blinking in line with well established EEG protocol. However, during performance of the time-estimation task, one of the two groups was provided with trial-to-trial-feedback about their performance on the time-estimation task and their eye movements to induce a higher level of cognitive load relative to participants in the other group who were solely provided with feedback about the accuracy of their temporal estimates. In line with previous work, we found that the higher level of cognitive load reduced the amplitude of the feedback-related negativity, a component of the human event-related brain potential associated with reward evaluation within the medial-frontal cortex. Importantly, our results provide further support that increased cognitive load reduces the functional efficacy of a neural system associated with reward processing. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Science.gov (United States)

    Meier, Beat; Zimmermann, Thomas D.

    2015-01-01

    In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially. PMID:26082709

  11. Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory.

    Science.gov (United States)

    Meier, Beat; Zimmermann, Thomas D

    2015-01-01

    In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  12. Priority hazardous substances for the aquatic environment: critical evaluation of the emission factor method for the indirect estimate of the loads

    International Nuclear Information System (INIS)

    Azzellino, A.; Vismara, R.

    2005-01-01

    The European Water Framework Directive require to the EU Member States the knowledge of the priority hazardous pollutant contamination levels. Regional basin management plans (according to Italian laws D.Lgs 152/99 and to D.M. 367/03) generally include a review about the status of water contamination to respond to the Eu legislation prescriptions. However, since the actual monitoring activity of the water contamination is expensive and also extremely difficult in terms of analytical sensitivity, the most of these reviews has been prepared by using indirect emission coefficient estimates derived form literature. It is well known that such emission coefficients have been rarely proved fully reliable; moreover such an approach gives no information about the variability affecting the emission estimates. Aim of this work was to use the data contained into the emission EPER-INES database, european database which contains the IPPC Directive emission declarations, to define emission coefficients more reliable than literature coefficients. The presented results, even though based on a limited number of observations and referring the most only to heavy metals, confirm the scarce affidability of the emission factor method and show remarkable discrepancies (mostly under- but also over-estimations of about ten-fold) of these emission estimates from the actual emission data of the IPPC declarations. These results allow also to evaluate the not negligible variability that affects the definition of emission coefficients [it

  13. Car transfer and wheelchair loading techniques in independent drivers with paraplegia

    Directory of Open Access Journals (Sweden)

    Lisa Lighthall Haubert

    2015-09-01

    Full Text Available Car transfers and wheelchair (WC loading are crucial for independent community participation in persons with complete paraplegia from spinal cord injury, but are complex, physically demanding, and known to provoke shoulder pain. This study aimed to describe techniques and factors influencing car transfer and WC loading for individuals with paraplegia driving their own vehicles and using their personal WCs. Sedans were the most common vehicle driven (59%. Just over half (52% of drivers place their right leg only into the vehicle prior to transfer. Overall, the leading hand was most frequently placed on the driver’s seat (66% prior to transfer and the trailing hand was most often place on the WC seat (48%. Vehicle height influenced leading hand placement but not leg placement such that driver’s of higher profile vehicles were more likely to place their hand on the driver’s seat than those who drove sedans. Body lift time was negatively correlated with level of injury and age and positively correlated with vehicle height and shoulder abduction strength. Drivers who transferred with their leading hand on the steering wheel had significantly higher levels of shoulder pain than those who placed their hand on the driver’s seat or overhead. The majority of participants used both hands (62% to load their WC frame and, overall, most loaded their fame into the back (62% vs. the front seat. Sedan drivers were more likely to load their frame into the front seat than drivers of higher profile vehicles (53% vs. 17%. Average time to load the WC frame (10.7 seconds was 20% of the total WC loading time and was not related to shoulder strength, frame weight or demographic characteristics. Those who loaded their WC frame into the back seat had significantly weaker right shoulder internal rotators. Understanding car transfers and WC loading in independent drivers is crucial to prevent shoulder pain and injury and preserve community participation.

  14. Development of Engine Loads Methodology, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR seeks to improve the definition of design loads for rocket engine components such that higher performing, lighter weight engines can be developed more...

  15. Load forecasting method considering temperature effect for distribution network

    Directory of Open Access Journals (Sweden)

    Meng Xiao Fang

    2016-01-01

    Full Text Available To improve the accuracy of load forecasting, the temperature factor was introduced into the load forecasting in this paper. This paper analyzed the characteristics of power load variation, and researched the rule of the load with the temperature change. Based on the linear regression analysis, the mathematical model of load forecasting was presented with considering the temperature effect, and the steps of load forecasting were given. Used MATLAB, the temperature regression coefficient was calculated. Using the load forecasting model, the full-day load forecasting and time-sharing load forecasting were carried out. By comparing and analyzing the forecast error, the results showed that the error of time-sharing load forecasting method was small in this paper. The forecasting method is an effective method to improve the accuracy of load forecasting.

  16. Fifty years of genetic load

    International Nuclear Information System (INIS)

    Wallace, B.

    1991-01-01

    This book discusses the radiation effects on Drosophila. It was originally thought that irradiating Drosophila would decrease the average fitness of the population, thereby leading to information about the detrimental effects of mutations. Surprisingly, the fitness of the irradiated population turned out to be higher than that of the control population. The original motivation for the experiment was as a test of genetic load theory. The average fitness of a population is depressed by deleterious alleles held in the population by the balance between mutation and natural selection. The depression is called the genetic load of the population. The load dose not depend on the magnitude of the deleterious effect of alleles, but only on the mutation rate

  17. Impact of load-related neural processes on feature binding in visuospatial working memory.

    Directory of Open Access Journals (Sweden)

    Nicole A Kochan

    Full Text Available BACKGROUND: The capacity of visual working memory (WM is substantially limited and only a fraction of what we see is maintained as a temporary trace. The process of binding visual features has been proposed as an adaptive means of minimising information demands on WM. However the neural mechanisms underlying this process, and its modulation by task and load effects, are not well understood. OBJECTIVE: To investigate the neural correlates of feature binding and its modulation by WM load during the sequential phases of encoding, maintenance and retrieval. METHODS AND FINDINGS: 18 young healthy participants performed a visuospatial WM task with independent factors of load and feature conjunction (object identity and position in an event-related functional MRI study. During stimulus encoding, load-invariant conjunction-related activity was observed in left prefrontal cortex and left hippocampus. During maintenance, greater activity for task demands of feature conjunction versus single features, and for increased load was observed in left-sided regions of the superior occipital cortex, precuneus and superior frontal cortex. Where these effects were expressed in overlapping cortical regions, their combined effect was additive. During retrieval, however, an interaction of load and feature conjunction was observed. This modulation of feature conjunction activity under increased load was expressed through greater deactivation in medial structures identified as part of the default mode network. CONCLUSIONS AND SIGNIFICANCE: The relationship between memory load and feature binding qualitatively differed through each phase of the WM task. Of particular interest was the interaction of these factors observed within regions of the default mode network during retrieval which we interpret as suggesting that at low loads, binding processes may be 'automatic' but at higher loads it becomes a resource-intensive process leading to disengagement of activity in this

  18. A gravity loading countermeasure skinsuit

    Science.gov (United States)

    Waldie, James M.; Newman, Dava J.

    2011-04-01

    Despite the use of several countermeasures, significant physiological deconditioning still occurs during long duration spaceflight. Bone loss - primarily due to the absence of loading in microgravity - is perhaps the greatest challenge to resolve. This paper describes a conceptual Gravity Loading Countermeasure Skinsuit (GLCS) that induces loading on the body to mimic standing and - when integrated with other countermeasures - exercising on Earth. Comfort, mobility and other operational issues were explored during a pilot study carried out in parabolic flight for prototype suits worn by three subjects. Compared to the 1- or 2-stage Russian Pingvin Suits, the elastic mesh of the GLCS can create a loading regime that gradually increases in hundreds of stages from the shoulders to the feet, thereby reproducing the weight-bearing regime normally imparted by gravity with much higher resolution. Modelling shows that the skinsuit requires less than 10 mmHg (1.3 kPa) of compression for three subjects of varied gender, height and mass. Negligible mobility restriction and excellent comfort properties were found during the parabolic flights, which suggests that crewmembers should be able to work normally, exercise or sleep while wearing the suit. The suit may also serve as a practical 1 g harness for exercise countermeasures and vibration applications to improve dynamic loading.

  19. Economic impact analysis of load forecasting

    International Nuclear Information System (INIS)

    Ranaweera, D.K.; Karady, G.G.; Farmer, R.G.

    1997-01-01

    Short term load forecasting is an essential function in electric power system operations and planning. Forecasts are needed for a variety of utility activities such as generation scheduling, scheduling of fuel purchases, maintenance scheduling and security analysis. Depending on power system characteristics, significant forecasting errors can lead to either excessively conservative scheduling or very marginal scheduling. Either can induce heavy economic penalties. This paper examines the economic impact of inaccurate load forecasts. Monte Carlo simulations were used to study the effect of different load forecasting accuracy. Investigations into the effect of improving the daily peak load forecasts, effect of different seasons of the year and effect of utilization factors are presented

  20. Wind Loads on Structures

    DEFF Research Database (Denmark)

    Dyrbye, Claes; Hansen, Svend Ole

    Wind loads have to be taken into account when designing civil engineering structures. The wind load on structures can be systematised by means of the wind load chain: wind climate (global), terrain (wind at low height), aerodynamic response (wind load to pressure), mechanical response (wind...... pressure to structural response) and design criteria. Starting with an introduction of the wind load chain, the book moves on to meteorological considerations, atmospheric boundary layer, static wind load, dynamic wind load and scaling laws used in wind-tunnel tests. The dynamic wind load covers vibrations...... induced by wind turbulence, vortex shedding, flutter and galloping. The book gives a comprehensive treatment of wind effects on structures and it will be useful for consulting engineers designing wind-sensitive structures. It will also be valuable for students of civil engineering as textbook...

  1. Carbohydrate-Loading Diet

    Science.gov (United States)

    ... Grape juice (12 ounces) 55 225 Lunch Milk, chocolate, reduced fat (12 ounces) 45 285 4 slices ... usual during carbohydrate loading to get the same benefits as a man does. Despite carbohydrate loading, you ...

  2. Autonomous Propellant Loading Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Autonomous Propellant Loading (APL) project consists of three activities. The first is to develop software that will automatically control loading of...

  3. Fuel pellet loading apparatus

    International Nuclear Information System (INIS)

    1980-01-01

    Apparatus is described for loading a predetermined amount of nuclear fuel pellets into nuclear fuel elements and particularly for the automatic loading of fuel pellets from within a sealed compartment. (author)

  4. Diffusion Indexes with Sparse Loadings

    DEFF Research Database (Denmark)

    Kristensen, Johannes Tang

    The use of large-dimensional factor models in forecasting has received much attention in the literature with the consensus being that improvements on forecasts can be achieved when comparing with standard models. However, recent contributions in the literature have demonstrated that care needs...... to the problem by using the LASSO as a variable selection method to choose between the possible variables and thus obtain sparse loadings from which factors or diffusion indexes can be formed. This allows us to build a more parsimonious factor model which is better suited for forecasting compared...... it to be an important alternative to PC....

  5. Limit loads in nozzles

    International Nuclear Information System (INIS)

    Zouain, N.

    1983-01-01

    The static method for the evaluation of the limit loads of a perfectly elasto-plastic structure is presented. Using the static theorem of Limit Analysis and the Finite Element Method, a lower bound for the colapso load can be obtained through a linear programming problem. This formulation if then applied to symmetrically loaded shells of revolution and some numerical results of limit loads in nozzles are also presented. (Author) [pt

  6. Friction and anchorage loading revisited.

    Science.gov (United States)

    Dholakia, Kartik D

    2012-01-01

    Contemporary concepts of sliding mechanics explain that friction is inevitable. To overcome this frictional resistance, excess force is required to retract the tooth along the archwire (ie, individual retraction of canines, en masse retraction of anterior teeth), in addition to the amount of force required for tooth movement. The anterior tooth retraction force, in addition to excess force (to overcome friction), produces reciprocal protraction force on molars, thereby leading to increased anchorage loading. However, this traditional concept was challenged in recent literature, which was based on the finite element model, but did not bear correlation to the clinical scenario. This article will reinforce the fact that clinically, friction increases anchorage loading in all three planes of space, considering the fact that tooth movement is a quasistatic process rather than a purely continuous or static one, and that conventional ways of determining the effects of static or dynamic friction on anchorage load cannot be applied to clinical situations (which consist of anatomical resistance units and a complex muscular force system). The article does not aim to quantify friction and its effect on the amount of anchorage load. Rather, a new perspective regarding the role of various additional factors (which is not explained by contemporary concept) that may influence friction and anchorage loading is provided..

  7. Children's Emotionality Moderates the Association Between Maternal Responsiveness and Allostatic Load: Investigation Into Differential Susceptibility.

    Science.gov (United States)

    Dich, Nadya; Doan, Stacey N; Evans, Gary W

    2015-01-01

    While emotionality is often thought of as a risk factor, differential susceptibility theory argues that emotionality reflects susceptibility to both positive and negative environmental influences. The present study explored whether emotional children might be more susceptible to the effects of both high and low maternal responsiveness on allostatic load, a physiological indicator of chronic stress. Participants were 226 mother and child dyads. Mothers reported on children's emotionality at child age 9. Maternal responsiveness was measured at age 13 using self-reports and behavioral observation. Allostatic load was measured at age 13 and 17 using neuroendocrine, cardiovascular, and metabolic biomarkers. Emotionality was associated with higher allostatic load if self-reported responsiveness was low, but with lower allostatic load, when self-reported responsiveness was high. © 2015 The Authors. Child Development © 2015 Society for Research in Child Development, Inc.

  8. Effects on fatigue life of gate valves due to higher torque switch settings during operability testing

    International Nuclear Information System (INIS)

    Richins, W.D.; Snow, S.D.; Miller, G.K.; Russell, M.J.; Ware, A.G.

    1995-12-01

    Some motor operated valves now have higher torque switch settings due to regulatory requirements to ensure valve operability with appropriate margins at design basis conditions. Verifying operability with these settings imposes higher stem loads during periodic inservice testing. These higher test loads increase stresses in the various valve internal parts which may in turn increase the fatigue usage factors. This increased fatigue is judged to be a concern primarily in the valve disks, seats, yokes, stems, and stem nuts. Although the motor operators may also have significantly increased loading, they are being evaluated by the manufacturers and are beyond the scope of this study. Two gate valves representative of both relatively weak and strong valves commonly used in commercial nuclear applications were selected for fatigue analyses. Detailed dimensional and test data were available for both valves from previous studies at the Idaho National Engineering Laboratory. Finite element models were developed to estimate maximum stresses in the internal parts of the valves and to identity the critical areas within the valves where fatigue may be a concern. Loads were estimated using industry standard equations for calculating torque switch settings prior and subsequent to the testing requirements of USNRC Generic Letter 89--10. Test data were used to determine both; (1) the overshoot load between torque switch trip and final seating of the disk during valve closing and (2) the stem thrust required to open the valves. The ranges of peak stresses thus determined were then used to estimate the increase in the fatigue usage factors due to the higher stem thrust loads. The usages that would be accumulated by 100 base cycles plus one or eight test cycles per year over 40 and 60 years of operation were calculated

  9. Competitiveness - higher education

    Directory of Open Access Journals (Sweden)

    Labas Istvan

    2016-03-01

    Full Text Available Involvement of European Union plays an important role in the areas of education and training equally. The member states are responsible for organizing and operating their education and training systems themselves. And, EU policy is aimed at supporting the efforts of member states and trying to find solutions for the common challenges which appear. In order to make our future sustainable maximally; the key to it lies in education. The highly qualified workforce is the key to development, advancement and innovation of the world. Nowadays, the competitiveness of higher education institutions has become more and more appreciated in the national economy. In recent years, the frameworks of operation of higher education systems have gone through a total transformation. The number of applying students is continuously decreasing in some European countries therefore only those institutions can “survive” this shortfall, which are able to minimize the loss of the number of students. In this process, the factors forming the competitiveness of these budgetary institutions play an important role from the point of view of survival. The more competitive a higher education institution is, the greater the chance is that the students would like to continue their studies there and thus this institution will have a greater chance for the survival in the future, compared to ones lagging behind in the competition. Aim of our treatise prepared is to present the current situation and main data of the EU higher education and we examine the performance of higher education: to what extent it fulfils the strategy for smart, sustainable and inclusive growth which is worded in the framework of Europe 2020 programme. The treatise is based on analysis of statistical data.

  10. Spatial electric load forecasting

    CERN Document Server

    Willis, H Lee

    2002-01-01

    Spatial Electric Load Forecasting Consumer Demand for Power and ReliabilityCoincidence and Load BehaviorLoad Curve and End-Use ModelingWeather and Electric LoadWeather Design Criteria and Forecast NormalizationSpatial Load Growth BehaviorSpatial Forecast Accuracy and Error MeasuresTrending MethodsSimulation Method: Basic ConceptsA Detailed Look at the Simulation MethodBasics of Computerized SimulationAnalytical Building Blocks for Spatial SimulationAdvanced Elements of Computerized SimulationHybrid Trending-Simulation MethodsAdvanced

  11. The Serenity of the Meditating Mind: A Cross-Cultural Psychometric Study on a Two-Factor Higher Order Structure of Mindfulness, Its Effects, and Mechanisms Related to Mental Health among Experienced Meditators

    Science.gov (United States)

    Tran, Ulrich S.; Cebolla, Ausiàs; Glück, Tobias M.; Soler, Joaquim; Garcia-Campayo, Javier; von Moy, Theresa

    2014-01-01

    Objective To investigate the psychometric and structural properties of the Five Facets Mindfulness Questionnaire (FFMQ) among meditators, to develop a short form, and to examine associations of mindfulness with mental health and the mechanisms of mindfulness. Methods Two independent samples were used, a German (n = 891) and a Spanish (n = 393) meditator sample, practicing various meditation styles. Structural and psychometric properties of the FFMQ were investigated with multigroup confirmatory factor analysis and exploratory structural equation modeling. Associations with mental health and mechanisms of mindfulness were examined with path analysis. Results The derived short form broadly matched a previous item selection in samples of non-meditators. Self-regulated Attention and Orientation to Experience governed the facets of mindfulness on a higher-order level. Higher-order factors of mindfulness and meditation experience were negatively associated with symptoms of depression and anxiety, and perceived stress. Decentering and nonattachment were the most salient mechanisms of mindfulness. Aspects of emotion regulation, bodily awareness, and nonattachment explained the effects of mindfulness on depression and anxiety. Conclusions A two-component conceptualization for the FFMQ, and for the study of mindfulness as a psychological construct, is recommended for future research. Mechanisms of mindfulness need to be examined in intervention studies. PMID:25330072

  12. The serenity of the meditating mind: a cross-cultural psychometric study on a two-factor higher order structure of mindfulness, its effects, and mechanisms related to mental health among experienced meditators.

    Directory of Open Access Journals (Sweden)

    Ulrich S Tran

    Full Text Available OBJECTIVE: To investigate the psychometric and structural properties of the Five Facets Mindfulness Questionnaire (FFMQ among meditators, to develop a short form, and to examine associations of mindfulness with mental health and the mechanisms of mindfulness. METHODS: Two independent samples were used, a German (n = 891 and a Spanish (n = 393 meditator sample, practicing various meditation styles. Structural and psychometric properties of the FFMQ were investigated with multigroup confirmatory factor analysis and exploratory structural equation modeling. Associations with mental health and mechanisms of mindfulness were examined with path analysis. RESULTS: The derived short form broadly matched a previous item selection in samples of non-meditators. Self-regulated Attention and Orientation to Experience governed the facets of mindfulness on a higher-order level. Higher-order factors of mindfulness and meditation experience were negatively associated with symptoms of depression and anxiety, and perceived stress. Decentering and nonattachment were the most salient mechanisms of mindfulness. Aspects of emotion regulation, bodily awareness, and nonattachment explained the effects of mindfulness on depression and anxiety. CONCLUSIONS: A two-component conceptualization for the FFMQ, and for the study of mindfulness as a psychological construct, is recommended for future research. Mechanisms of mindfulness need to be examined in intervention studies.

  13. Project Management in Higher Education

    Science.gov (United States)

    Alpert, Shannon Atkinson

    2011-01-01

    This study identified factors that influenced the use of project management in higher education research projects. Using a qualitative grounded theory approach that included in-depth interviews with assistant professors, the researcher examined how these individuals were using project management processes and tools and factors that enabled,…

  14. Probabilistic model of bridge vehicle loads in port area based on in-situ load testing

    Science.gov (United States)

    Deng, Ming; Wang, Lei; Zhang, Jianren; Wang, Rei; Yan, Yanhong

    2017-11-01

    Vehicle load is an important factor affecting the safety and usability of bridges. An statistical analysis is carried out in this paper to investigate the vehicle load data of Tianjin Haibin highway in Tianjin port of China, which are collected by the Weigh-in- Motion (WIM) system. Following this, the effect of the vehicle load on test bridge is calculated, and then compared with the calculation result according to HL-93(AASHTO LRFD). Results show that the overall vehicle load follows a distribution with a weighted sum of four normal distributions. The maximum vehicle load during the design reference period follows a type I extremum distribution. The vehicle load effect also follows a weighted sum of four normal distributions, and the standard value of the vehicle load is recommended as 1.8 times that of the calculated value according to HL-93.

  15. The Factors of Soldier’s Load

    Science.gov (United States)

    1994-06-03

    turtles . My ruck weighed 120 pounds. American Airborne Soldier Grenada, 1983 One of the tenets of Army doctrine in Field Manual 100-5 QIp.r.aition•. is...from a lack of the appropriate physical conditioning in some units; and the more nebulous problem of insufficient logistical challenges built into

  16. Effects of static pre-loading on the dynamic stability of a column on ...

    African Journals Online (AJOL)

    This paper presents, from strictly analytical consideration, the dynamic analysis of a finite column stressed by a step load but in the presence of a previously imposed static load. The results show that (a) the dynamic buckling load for this type of loading is relatively higher than that of a similar column stressed by a step load ...

  17. Retrospective Analysis of Inflight Exercise Loading and Physiological Outcomes

    Science.gov (United States)

    Ploutz-Snyder, L. L.; Buxton, R. E.; De Witt, J. K.; Guilliams, M. E.; Hanson, A. M.; Peters, B. T.; Pandorf, M. M. Scott; Sibonga, J. D.

    2014-01-01

    Astronauts perform exercise throughout their missions to counter the health declines that occur as a result of long-term exposure to weightlessness. Although all astronauts perform exercise during their missions, the specific prescriptions, and thus the mechanical loading, differs among individuals. For example, inflight ground reaction force data indicate that subject-specific differences exist in foot forces created when exercising on the second-generation treadmill (T2) [1]. The current exercise devices allow astronauts to complete prescriptions at higher intensities, resulting in greater benefits with increased efficiency. Although physiological outcomes have improved, the specific factors related to the increased benefits are unknown. In-flight exercise hardware collect data that allows for exploratory analyses to determine if specific performance factors relate to physiological outcomes. These analyses are vital for understanding which components of exercise are most critical for optimal human health and performance. The relationship between exercise performance variables and physiological changes during flight has yet to be fully investigated. Identifying the critical performance variables that relate to improved physiological outcomes is vital for creating current and future exercise prescriptions to optimize astronaut health. The specific aims of this project are: 1) To quantify the exercise-related mechanical loading experienced by crewmembers on T2 and ARED during their mission on ISS; 2) To explore relationships between exercise loading variables, bone, and muscle health changes during the mission; 3) To determine if specific mechanical loading variables are more critical than others in protecting physiology; 4) To develop methodology for operational use in monitoring accumulated training loads during crew exercise programs. This retrospective analysis, which is currently in progress, is being conducted using data from astronauts that have flown long

  18. The DEMO wall load challenge

    Czech Academy of Sciences Publication Activity Database

    Wenninger, R.; Albanese, R.; Ambrosino, R.; Arbeiter, F.; Aubert, J.; Bachmann, C.; Barbato, L.; Barrett, T.; Beckers, M.; Biel, W.; Boccaccini, L.; Carralero, D.; Coster, D.; Eich, T.; Fasoli, A.; Federici, G.; Firdaouss, M.; Graves, J.; Horáček, Jan; Kovari, M.; Lanthaler, S.; Loschiavo, V.; Lowry, C.; Lux, H.; Maddaluno, G.; Maviglia, F.; Mitteau, R.; Neu, R.; Pfefferle, D.; Schmid, K.; Siccinio, M.; Sieglin, B.; Silva, C.; Snicker, A.; Subba, F.; Varje, J.; Zohm, H.

    2017-01-01

    Roč. 57, č. 4 (2017), č. článku 046002. ISSN 0029-5515 EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : DEMO * power loads * first wall Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 3.307, year: 2016 http://iopscience.iop.org/article/10.1088/1741-4326/aa4fb4

  19. Daily Air Temperature and Electricity Load in Spain.

    Science.gov (United States)

    Valor, Enric; Meneu, Vicente; Caselles, Vicente

    2001-08-01

    Weather has a significant impact on different sectors of the economy. One of the most sensitive is the electricity market, because power demand is linked to several weather variables, mainly the air temperature. This work analyzes the relationship between electricity load and daily air temperature in Spain, using a population-weighted temperature index. The electricity demand shows a significant trend due to socioeconomic factors, in addition to daily and monthly seasonal effects that have been taken into account to isolate the weather influence on electricity load. The results indicate that the relationship is nonlinear, showing a `comfort interval' of ±3°C around 18°C and two saturation points beyond which the electricity load no longer increases. The analysis has also revealed that the sensitivity of electricity load to daily air temperature has increased along time, in a higher degree for summer than for winter, although the sensitivity in the cold season is always more significant than in the warm season. Two different temperature-derived variables that allow a better characterization of the observed relationship have been used: the heating and cooling degree-days. The regression of electricity data on them defines the heating and cooling demand functions, which show correlation coefficients of 0.79 and 0.87, and predicts electricity load with standard errors of estimate of ±4% and ±2%, respectively. The maximum elasticity of electricity demand is observed at 7 cooling degree-days and 9 heating degree-days, and the saturation points are reached at 11 cooling degree-days and 13 heating degree-days, respectively. These results are helpful in modeling electricity load behavior for predictive purposes.

  20. Cognitive Load Alters Neuronal Processing of Food Odors.

    Science.gov (United States)

    Hoffmann-Hensel, Sonja Maria; Sijben, Rik; Rodriguez-Raecke, Rea; Freiherr, Jessica

    2017-10-31

    Obesity is a major health concern in modern societies. Although decreased physical activity and enhanced intake of high-caloric foods are important risk factors for developing obesity, human behavior during eating also plays a role. Previous studies have shown that distraction while eating increases food intake and leads to impaired processing of food stimuli. As olfaction is the most important sense involved in flavor perception, we used functional magnetic resonance imaging techniques to investigate the influence of cognitive memory load on olfactory perception and processing. Low- and high-caloric food odors were presented in combination with either low or high cognitive loads utilizing a memory task. The efficacy of the memory task was verified by a decrease in participant recall accuracy and an increase in skin conductance response during high cognitive load. Our behavioral data reveal a diminished perceived intensity for low- but not high-caloric food odors during high cognitive load. For low-caloric food odors, bilateral orbitofrontal (OFC) and piriform cortices (pirC) showed significantly lower activity during high compared with low cognitive load. For high-caloric food odors, a similar effect was established in pirC, but not in OFC. Insula activity correlates with higher intensity ratings found during the low cognitive load condition. We conclude lower activity in pirC and OFC to be responsible for diminished intensity perception, comparable to results in olfactory impaired patients and elderly. Further studies should investigate the influence of olfactory/gustatory intensities on food choices under distraction with special regards to low-caloric food. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.