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  1. Preliminary Screening a Potential AChE Inhibitor in Thai Golden Shower (Leguminosae mimosoideae Extracts

    Directory of Open Access Journals (Sweden)

    Jakkaphun Nanuam

    2013-07-01

    Full Text Available Pesticides are used to control pests of agriculture products in many countries including Thailand. Since they can exert harmful effects not only on target pests but also on other useful organisms, alternative agents are investigated. We studied the capacity of the Thai golden shower (Leguminosae mimosoideae extracts (root and pod to inhibit acetyl cholinestarese (AChE in the golden apple snail (Pomacea canaliculata as a pest representative. The results showed that the percentage of AChE inhibition increased with increasing in exposure times. The inhibition expressed the same trend in both male and female apple snails. AChE inhibition was higher in extracts from root than from pod. Chromatography-Mass Spectrometer (GC-MS chromatograms demonstrated anthraquinone, an AChE inhibitor, in extracts of golden shower. Our data indicate that a potential AChE inhibitor tends to accumulate more in the root part than in the pod.

  2. Toxicological and biochemical characterizations of AChE in phosalone-susceptible and resistant populations of the common pistachio psyllid, Agonoscena pistaciae

    Science.gov (United States)

    Alizadeh, Ali; Talebi-Jahromi, Khalil; Hosseininaveh, Vahid; Ghadamyari, Mohammad

    2014-01-01

    Abstract The toxicological and biochemical characteristics of acetylcholinesterases (AChE) in nine populations of the common pistachio psyllid, Agonoscena pistaciae Burckhardt and Lauterer (Hemiptera: Psyllidae), were investigated in Kerman Province, Iran. Nine A. pistaciae populations were collected from pistachio orchards, Pistacia vera L. (Sapindales: Anacardiaceae), located in Rafsanjan, Anar, Bam, Kerman, Shahrbabak, Herat, Sirjan, Pariz, and Paghaleh regions of Kerman province. The previous bioassay results showed these populations were susceptible or resistant to phosalone, and the Rafsanjan population was most resistant, with a resistance ratio of 11.3. The specific activity of AChE in the Rafsanjan population was significantly higher than in the susceptible population (Bam). The affinity ( KM ) and hydrolyzing efficiency ( Vmax ) of AChE on acetylthiocholine iodide, butyrylthiocholine iodide, and propionylthiocholine odide as artificial substrates were clearly lower in the Bam population than that in the Rafsanjan population. These results indicated that the AChE of the Rafsanjan population had lower affinity to these substrates than that of the susceptible population. The higher Vmax value in the Rafsanjan population compared to the susceptible population suggests a possible over expression of AChE in the Rafsanjan population. The in vitro inhibitory effect of several organophosphates and carbamates on AChE of the Rafsanjan and Bam populations was determined. Based on I50, the results showed that the ratios of AChE insensitivity of the resistant to susceptible populations were 23 and 21.7-fold to monocrotophos and phosphamidon, respectively. Whereas, the insensitivity ratios for Rafsanjan population were 0.86, 0.8, 0.78, 0.46, and 0.43 for carbaryl, eserine, propoxur, m-tolyl methyl carbamate, and carbofuran, respectively, suggesting negatively correlated sensitivity to organophosphate-insensitive AChE. Therefore, AChE from the Rafsanjan population showed

  3. Assessing the reactivation efficacy of hydroxylamine anion towards VX-inhibited AChE: a computational study.

    Science.gov (United States)

    Khan, Md Abdul Shafeeuulla; Ganguly, Bishwajit

    2012-05-01

    Oximate anions are used as potential reactivating agents for OP-inhibited AChE because of they possess enhanced nucleophilic reactivity due to the α-effect. We have demonstrated the process of reactivating the VX-AChE adduct with formoximate and hydroxylamine anions by applying the DFT approach at the B3LYP/6-311 G(d,p) level of theory. The calculated results suggest that the hydroxylamine anion is more efficient than the formoximate anion at reactivating VX-inhibited AChE. The reaction of formoximate anion and the VX-AChE adduct is a three-step process, while the reaction of hydroxylamine anion with the VX-AChE adduct seems to be a two-step process. The rate-determining step in the process is the initial attack on the VX of the VX-AChE adduct by the nucleophile. The subsequent steps are exergonic in nature. The potential energy surface (PES) for the reaction of the VX-AChE adduct with hydroxylamine anion reveals that the reactivation process is facilitated by the lower free energy of activation (by a factor of 1.7 kcal mol(-1)) than that of the formoximate anion at the B3LYP/6-311 G(d,p) level of theory. The higher free energy of activation for the reverse reactivation reaction between hydroxylamine anion and the VX-serine adduct further suggests that the hydroxylamine anion is a very good antidote agent for the reactivation process. The activation barriers calculated in solvent using the polarizable continuum model (PCM) for the reactivation of the VX-AChE adduct with hydroxylamine anion were also found to be low. The calculated results suggest that V-series compounds can be more toxic than G-series compounds, which is in accord with earlier experimental observations.

  4. Research of small quaternary AChE inhibitors as pretreatment of OP poisoning

    International Nuclear Information System (INIS)

    Musilek, K.; Komloova, M.; Holas, O.; Opletalova, V.; Pohanka, M.; Kuca, K.

    2009-01-01

    Small quaternary AChE inhibitors are used (e.g. pyridostigmine) or scoped (e.g. SAD-128) for pretreatment against organophosphate intoxication [1]. The pretreatment is based on competitive inhibition of AChE prior to organophosphate (OP) poisoning. Consequently, the OP can not influence the inhibited AChE and is degraded by other esterases. Although various competitive inhibitors are used globally, pyridostigmine still remains the most broaden. Its side effects including gastrointestinal effects (nausea, intestinal obstruction), increased bronchial secretion, cardiac arrhythmia or cholinergic crisis are well described. Moreover, some bisquaternary competitive inhibitors (e.g. SAD-128) were used to decrease lethal effects of OP poisoning in vivo. The further studies dealing with SAD-128 showed its increased ability to interact with brain muscarinic acetylcholine receptors as allosteric inhibitors [2]. The small molecules derived from quaternized pyridine, quinoline and isoquinoline were designed as AChE inhibitors. Their ability to inhibit AChE or BChE was determined in vitro using IC50. The IC50 data were compared within each group of compounds with emphasis on selectivity AChE versus BChE. The overall study will be presented. The work was supported by Ministry of Defence of Czech Republic No. OVUOFVZ200805.(author)

  5. Measurement of acetylcholinesterase (AChE) activity in living brain by positron emission tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Irie, Toshiaki [National Inst. of Radiological Sciences, Chiba (Japan)

    1999-07-01

    Central cholinergic neuronal system has been known to be related to learning and memory, and its deficit is found in the brain of Alzheimer's disease (AD) and other degenerative disorders. Postmortem studies have shown that acetylcholinesterase (AChE), one of biochemical markers of central cholinergic nerve system, is consistently reduced in the cerebral cortex of patients with Alzheimer's disease (AD). Non-invasive mapping and/or measuring AChE activity in the living brain by positron emission tomography (PET) would be a useful tool for assessment of cholinergic dysfunction in AD and other disorders, and provide a direct method for validation of therapeutic efficacy of drugs, AChE inhibitors. We have challenged to measure AChE activity using tracers of substrate type, radiolabelled acetylcholine analogs, which are lipophilic enough to go across blood brain barrier and are metabolically trapped by AChE in the brain. The analogs designed, N-methylpiperidyl esters, were evaluated in terms of their metabolic rate and specificity against AChE. Studies examining the response to AChE activity showed metabolic accumulation of some analogs responded well to changes in cortical AChE activity in an animal model of AD. The study was further applied to living human by PET using [{sup 11}C]N-methylpiperidyl-4-acetate (MP4A), which was chosen on the basis of its reactivity and specificity suitable for the human cortical AChE. Regional cerebral metabolic rate of MP4A reflecting AChE activity was quantitatively determined using three compartment model analysis of dynamic PET data and the arterial input function obtained by TLC-radioluminography or plasma samples. The kinetic analyses showed that AChE activities estimated were well agree with those of postmortem examination in cerebral cortices and thalamus in healthy subjects, and that there was significant reduction of cortical AChE activity in patients with AD. The results suggest feasibility of the present method for

  6. Centrally Acting Oximes in Reactivation of Tabun-Phosphoramidated AChE

    Science.gov (United States)

    Kovarik, Zrinka; Maček, Nikolina; Sit, Rakesh K.; Radić, Zoran; Fokin, Valery V.; Sharpless, K. Barry; Taylor, Palmer

    2012-01-01

    Organophosphates (OP) inhibit acetylcholinesterase (AChE, E.C.3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). The currently used therapy, focusing on the reactivation of inhibited AChE, is limited to peripheral tissues because commonly used quaternary pyridinium oxime reactivators do not cross the blood brain barrier (BBB) at therapeutically relevant levels. A directed library of thirty uncharged oximes that contain tertiary amine or imidazole protonable functional groups that should cross the BBB as unionized species was tested as tabun-hAChE conjugate reactivators along with three reference oximes: DAM (diacetylmonoxime), MINA (monoisonitrosoacetone), and 2-PAM. The oxime RS150D [N-((1-(3-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)benzamide] was highlighted as the most promising reactivator of the tabun-hAChE conjugate. We also observed that oximes RS194B [N-(2-(azepan-1-yl)ethyl)-2-(hydroxyimino)acetamide] and RS41A [2-(hydroxyimino)-N-(2-(pyrrolidin-1-yl)ethyl)acetamide], which emerged as lead uncharged reactivators of phosphylated hAChE with other OPs (sarin, cyclosarin and VX), exhibited only moderate reactivation potency for tabun inhibited hAChE. This implies that geometry of oxime access to the phosphorus atom conjugated to the active serine is an important criterion for efficient reactivation, along with the chemical nature of the conjugated moiety: phosphorate, phosphonate, or phosphoramidate. Moreover, modification of the active center through mutagenesis enhances the rates of reactivation. The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes (RS113B, RS113A and RS115A) and acetamide derivative (RS194B) than with 2PAM. PMID:22960624

  7. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy.

    Science.gov (United States)

    Murray, Ana Paula; Faraoni, María Belén; Castro, María Julia; Alza, Natalia Paola; Cavallaro, Valeria

    2013-07-01

    As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer's disease and alleviating the symptoms of this neurological disorder. This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.

  8. [Women's approach to childhood toothache, abdominal ache and earache].

    Science.gov (United States)

    Efe, Emine; Öncel, Selma; Yilmaz, Mualla

    2012-01-01

    This study was conducted to determine women's about attitudes child's teeth, abdomen and ear ache. Those who had lived in Antalya that 6 number primary health care center between March-May 2004 were enrolled in the study. As data collecting tools. A questionnaire prepared by the authors. This study was determined that 29.2 % of the mothers carried out mixture who had prepared at home to child's abdomen and foot base; 30.3 % were to put breast milk childs' ear; 38.9 % were placed aspirin, salt and salts of lemon to childs' teeth ache. The majority of the women make a wrong practices child that teeth, abdomen and ear ache. This traditional practice effecting factors were the women's educational status and age. The results of the study that education about child care, common health problems and incorrect applications shoud be given to women by nurse.

  9. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

    OpenAIRE

    Murray, Ana Paula; Faraoni, María Belén; Castro, María Julia; Alza, Natalia Paola; Cavallaro, Valeria

    2013-01-01

    As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer’s disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the le...

  10. Interactions of AChE with Aβ Aggregates in Alzheimer’s Brain: Therapeutic Relevance of IDN 5706

    Directory of Open Access Journals (Sweden)

    Francisco Javier Carvajal

    2011-09-01

    Full Text Available Acetylcholinesterase (AChE; EC 3.1.1.7 plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. Alzheimer’s disease (AD is a neurodegenerative disorder characterized by a progressive deterioration of cognitive abilities, amyloid-β peptide (Aβ accumulation and synaptic alterations. We have previously shown that AChE is able to accelerate the Aβ peptide assembly into Alzheimer-type aggregates increasing its neurotoxicity. Furthermore, AChE activity is altered in brain and blood of Alzheimer’s patients. The enzyme associated to amyloid plaques changes its enzymatic and pharmacological properties, as well as, increases its resistant to low pH, inhibitors and excess of substrate. Here, we reviewed the effects of IDN 5706, a hyperforin derivative that has potential preventive effects on the development of AD. Our results show that treatment with IDN5706 for 10 weeks increases brain AChE activity in seven month-old double transgenic mice (APPswe - PS1 and decreases the content of AChE associated with different types of amyloid plaques in this Alzheimer’s model. We concluded that early treatment with IDN 5706 decreases AChE-Aβ interaction and this effect might be of therapeutic interest in the treatment of AD.

  11. Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion.

    Science.gov (United States)

    Camp, Shelley; Zhang, Limin; Marquez, Michael; de la Torre, Brian; Long, Jeffery M; Bucht, Goran; Taylor, Palmer

    2005-12-15

    AChE is an alternatively spliced gene. Exons 2, 3 and 4 are invariantly spliced, and this sequence is responsible for catalytic function. The 3' alternatively spliced exons, 5 and 6, are responsible for AChE disposition in tissue [J. Massoulie, The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11 (3) (2002) 130-143; Y. Li, S. Camp, P. Taylor, Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 (8) (1993) 5790-5797]. The splice to exon 5 produces the GPI anchored form of AChE found in the hematopoietic system, whereas the splice to exon 6 produces a sequence that binds to the structural subunits PRiMA and ColQ, producing AChE expression in brain and muscle. A third alternative RNA species is present that is not spliced at the 3' end; the intron 3' of exon 4 is used as coding sequence and produces the read-through, unanchored form of AChE. In order to further understand the role of alternative splicing in the expression of the AChE gene, we have used homologous recombination in stem cells to produce gene specific deletions in mice. Alternatively and together exon 5 and exon 6 were deleted. A cassette containing the neomycin gene flanked by loxP sites was used to replace the exon(s) of interest. Tissue analysis of mice with exon 5 deleted and the neomycin cassette retained showed very low levels of AChE expression, far less than would have been anticipated. Only the read-through species of the enzyme was produced; clearly the inclusion of the selection cassette disrupted splicing of exon 4 to exon 6. The selection cassette was then deleted in exon 5, exon 6 and exons 5 + 6 deleted mice by breeding to Ella-cre transgenic mice. AChE expression in serum, brain and muscle has been analyzed. Another AChE gene targeted mouse strain involving a region in the first intron, found to be critical for AChE expression in muscle cells [S. Camp, L. Zhang, M. Marquez, B

  12. Novel bis-(−)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Wei [Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 200032 (China); NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032 (China); Li, Juan [Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025 (China); Qiu, Zhuibai [Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 200032 (China); Xia, Zheng [Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025 (China); Li, Wei [Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 200032 (China); Yu, Lining; Chen, Hailin; Chen, Jianxing [NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032 (China); Chen, Yan; Hu, Zhuqin; Zhou, Wei; Shao, Biyun; Cui, Yongyao [Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025 (China); Xie, Qiong, E-mail: xiejoanxq@gmail.com [Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 200032 (China); Chen, Hongzhuan, E-mail: yaoli@shsmu.edu.cn [Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025 (China)

    2012-10-01

    The strategy of dual binding site acetylcholinesterase (AChE) inhibition along with metal chelation may represent a promising direction for multi-targeted interventions in the pathophysiological processes of Alzheimer's disease (AD). In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(−)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. They could inhibit human AChE activity with IC{sub 50} values of 9.63 μM (for ZLA) and 8.64 μM (for ZLB), and prevent AChE-induced amyloid-β (Aβ) aggregation with IC{sub 50} values of 49.1 μM (for ZLA) and 55.3 μM (for ZLB). In parallel, molecular docking analysis showed that they are capable of interacting with both the catalytic and peripheral anionic sites of AChE. Furthermore, they exhibited abilities to complex metal ions such as Cu(II) and Zn(II), and inhibit Aβ aggregation triggered by these metals. Collectively, these results suggest that ZLA and ZLB may act as dual binding site AChEIs with metal-chelating potency, and may be potential leads of value for further study on disease-modifying treatment of AD. -- Highlights: ► Two novel bis-(−)-nor-meptazinol derivatives are designed and synthesized. ► ZLA and ZLB may act as dual binding site AChEIs with metal-chelating potency. ► They are potential leads for disease-modifying treatment of Alzheimer's disease.

  13. Novel bis-(−)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property

    International Nuclear Information System (INIS)

    Zheng, Wei; Li, Juan; Qiu, Zhuibai; Xia, Zheng; Li, Wei; Yu, Lining; Chen, Hailin; Chen, Jianxing; Chen, Yan; Hu, Zhuqin; Zhou, Wei; Shao, Biyun; Cui, Yongyao; Xie, Qiong; Chen, Hongzhuan

    2012-01-01

    The strategy of dual binding site acetylcholinesterase (AChE) inhibition along with metal chelation may represent a promising direction for multi-targeted interventions in the pathophysiological processes of Alzheimer's disease (AD). In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(−)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. They could inhibit human AChE activity with IC 50 values of 9.63 μM (for ZLA) and 8.64 μM (for ZLB), and prevent AChE-induced amyloid-β (Aβ) aggregation with IC 50 values of 49.1 μM (for ZLA) and 55.3 μM (for ZLB). In parallel, molecular docking analysis showed that they are capable of interacting with both the catalytic and peripheral anionic sites of AChE. Furthermore, they exhibited abilities to complex metal ions such as Cu(II) and Zn(II), and inhibit Aβ aggregation triggered by these metals. Collectively, these results suggest that ZLA and ZLB may act as dual binding site AChEIs with metal-chelating potency, and may be potential leads of value for further study on disease-modifying treatment of AD. -- Highlights: ► Two novel bis-(−)-nor-meptazinol derivatives are designed and synthesized. ► ZLA and ZLB may act as dual binding site AChEIs with metal-chelating potency. ► They are potential leads for disease-modifying treatment of Alzheimer's disease.

  14. Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.

    Science.gov (United States)

    Ghosh, Shibaji; Chandar, Nellore Bhanu; Jana, Kalyanashis; Ganguly, Bishwajit

    2017-08-01

    Inhibition of acetylcholinesterase (AChE) with organophosphorus compounds has a detrimental effect on human life. Oxime K203 seems to be one of the promising reactivators for tabun-inhibited AChE than (K027, K127, and K628). These reactivators differ only in the linker units between the two pyridinium rings. The conformational analyses performed with quantum chemical RHF/6-31G* level for K027, K127, K203 and K628 showed that the minimum energy conformers have different orientations of the active and peripheral pyridinium rings for these reactivator molecules. K203 with (-CH 2 -CH=CH-CH 2 -) linker unit possesses more open conformation compared to the other reactivators. Such orientation of K203 experiences favorable interaction with the surrounding residues of catalytic anionic site (CAS) and peripheral anionic site (PAS) of tabun-inhibited AChE. From the steered molecular dynamics simulations, it has been observed that the oxygen atom of the oxime group of K203 reactivator approaches nearest to the P-atom of the SUN203 (3.75 Å) at lower time scales (less than ~1000 ps) as compared to the other reactivators. K203 experiences less number of hydrophobic interaction with the PAS residues which is suggested to be an important factor for the efficient reactivation process. In addition, K203 crates large number of H-bonding with CAS residues SUN203, Phe295, Tyr337, Phe338 and His447. K203 barely changes its conformation during the SMD simulation process and hence the energy penalty to adopt any other conformation is minimal in this case as compared to the other reactivators. The molecular mechanics and Poisson-Boltzmann surface area binding energies obtained for the interaction of K203 inside the gorge of tabun inhibited AChE is substantially higher (-290.2 kcal/mol) than the corresponding K628 reactivator (-260.4 kcal/mol), which also possess unsaturated aromatic linker unit.

  15. Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies

    Science.gov (United States)

    Ghosh, Shibaji; Chandar, Nellore Bhanu; Jana, Kalyanashis; Ganguly, Bishwajit

    2017-08-01

    Inhibition of acetylcholinesterase (AChE) with organophosphorus compounds has a detrimental effect on human life. Oxime K203 seems to be one of the promising reactivators for tabun-inhibited AChE than (K027, K127, and K628). These reactivators differ only in the linker units between the two pyridinium rings. The conformational analyses performed with quantum chemical RHF/6-31G* level for K027, K127, K203 and K628 showed that the minimum energy conformers have different orientations of the active and peripheral pyridinium rings for these reactivator molecules. K203 with (-CH2-CH=CH-CH2-) linker unit possesses more open conformation compared to the other reactivators. Such orientation of K203 experiences favorable interaction with the surrounding residues of catalytic anionic site (CAS) and peripheral anionic site (PAS) of tabun-inhibited AChE. From the steered molecular dynamics simulations, it has been observed that the oxygen atom of the oxime group of K203 reactivator approaches nearest to the P-atom of the SUN203 (3.75 Å) at lower time scales (less than 1000 ps) as compared to the other reactivators. K203 experiences less number of hydrophobic interaction with the PAS residues which is suggested to be an important factor for the efficient reactivation process. In addition, K203 crates large number of H-bonding with CAS residues SUN203, Phe295, Tyr337, Phe338 and His447. K203 barely changes its conformation during the SMD simulation process and hence the energy penalty to adopt any other conformation is minimal in this case as compared to the other reactivators. The molecular mechanics and Poisson-Boltzmann surface area binding energies obtained for the interaction of K203 inside the gorge of tabun inhibited AChE is substantially higher (-290.2 kcal/mol) than the corresponding K628 reactivator (-260.4 kcal/mol), which also possess unsaturated aromatic linker unit.

  16. Evaluation of the Toxicity, AChE Activity and DNA Damage Caused by Imidacloprid on Earthworms, Eisenia fetida.

    Science.gov (United States)

    Wang, Kai; Qi, Suzhen; Mu, Xiyan; Chai, Tingting; Yang, Yang; Wang, Dandan; Li, Dongzhi; Che, Wunan; Wang, Chengju

    2015-10-01

    Imidacloprid is a well-known pesticide and it is timely to evaluate its toxicity to earthworms (Eisenia fetida). In the present study, the effect of imidacloprid on reproduction, growth, acetylcholinesterase (AChE) and DNA damage in earthworms was assessed using an artificial soil medium. The median lethal concentration (LC50) and the median number of hatched cocoons (EC50) of imidacloprid to earthworms was 3.05 and 0.92 mg/kg respectively, the lowest observed effect concentration of imidacloprid about hatchability, growth, AChE activity and DNA damage was 0.02, 0.5, 0.1 and 0.5 mg/kg, respectively.

  17. THE ROLES OF DETOXIFYING ENZYMES AND AChE INSENSITIVITY IN METHAMIDOPHOS RESISTANCE DEVELOPMENT AND DECLINE IN NILAPARVATA LUGENS

    Institute of Scientific and Technical Information of China (English)

    Ze-wenLiu; Zhao-junHan; Ling-chunZhang

    2003-01-01

    Methamidophos resistance of brown planthopper (Nilaparvata lugens Stal, BPH) was selected in laboratory. After successive selection for 9 generations, the selection was ceased by rearing BPH without contact with any insecticide for 9 generations. In the full course, the successive changes of esterase activity, MFO activity, GSTs activity and AChE insensitivity were analyzed. The results showed that the change of esterase activity was high correlated with that of methamidophos in the full course, which indicated that esterase played very important role both in the resistance development and in the resistance decline. However, the change of AChE insensitivity only significantly correlated with that of resistance in the development stage, and the change of MFO activity or GSTs activity only significantly correlated with that of the resistance in the decline stage, which indicated the changes of AChE insensitivity, MFO activity or GSTs activity only played some roles in different stages of the resistance change.

  18. The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure

    Directory of Open Access Journals (Sweden)

    Qing Ren

    2017-01-01

    Full Text Available The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. In order to assess the role of acetylcholinesterase (AChE in swimming behavior of Daphnia magna, a correlation analysis of both parameters in 24 h exposure of deltamethrin (DM and methomyl (MT was investigated. The behavior responses of D. magna in DM (13.36 μg/L and 33.40 μg/L and MT (19.66 μg/L and 49.15 μg/L suggested that recovery behavior in the adjustment phase was crucial, and behavior homeostasis provided them with an optimal way to achieve a wider tolerance against environmental stress. During the experiment, positive effects on AChE activity occurred in the beginning of the exposure. Even though the de novo synthesis of AChE in D. magna might help it recover, the AChE inhibition in different treatments could be observed. Some induction effects on AChE activity at the beginning of exposure occurred, and a 50% decrease may cause toxic effects on behavior. In most treatments, the results showed that both behavior strength and AChE activity stayed in the same field within a correlation circle. These results illustrated that the environmental stress caused by both DM and MT could inhibit AChE activity and subsequently induce a stepwise behavior response, though both pesticides affect it as direct and indirect inhibitors, respectively.

  19. Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies.

    Science.gov (United States)

    Lo, Rabindranath; Ganguly, Bishwajit

    2014-07-29

    Organophosphorus nerve agents are highly toxic compounds which strongly inhibit acetylcholinesterase (AChE) in the blood and in the central nervous system (CNS). Tabun is one of the highly toxic organophosphorus (OP) compounds and is resistant to many oxime drugs formulated for the reactivation of AChE. The reactivation mechanism of tabun-conjugated AChE with various drugs has been examined with density functional theory and ab initio quantum chemical calculations. The presence of a lone-pair located on the amidic group resists the nucleophilic attack at the phosphorus center of the tabun-conjugated AChE. We have shown that the newly designed drug candidate N-(pyridin-2-yl)hydroxylamine, at the MP2/6-31+G*//M05-2X/6-31G* level in the aqueous phase with the polarizable continuum solvation model (PCM), is more effective in reactivating the tabun-conjugated AChE than typical oxime drugs. The rate determining activation barrier with N-(pyridin-2-yl)hydroxylamine was found to be ∼1.7 kcal mol(-1), which is 7.2 kcal mol(-1) lower than the charged oxime trimedoxime (one of the most efficient reactivators in tabun poisonings). The greater nucleophilicity index (ω(-)) and higher CHelpG charge of pyridinylhydroxylamine compared to TMB4 support this observation. Furthermore, we have also examined the reactivation process of tabun-inhibited AChE with some other bis-quaternary oxime drug candidates such as methoxime (MMB4) and obidoxime. The docking analysis suggests that charged bis-quaternary pyridinium oximes have greater binding affinity inside the active-site gorge of AChE compared to the neutral pyridinylhydroxylamine. The peripheral ligand attached to the neutral pyridinylhydroxylamine enhanced the binding with the aromatic residues in the active-site gorge of AChE through effective π-π interactions. Steered molecular dynamics (SMD) simulations have also been performed with the charged oxime (TMB4) and the neutral hydroxylamine. From protein-drug interaction

  20. Selenofuranoside Ameliorates Memory Loss in Alzheimer-Like Sporadic Dementia: AChE Activity, Oxidative Stress, and Inflammation Involvement

    Directory of Open Access Journals (Sweden)

    Cristiano Chiapinotto Spiazzi

    2015-01-01

    Full Text Available Alzheimer’s disease (AD is becoming more common due to the increase in life expectancy. This study evaluated the effect of selenofuranoside (Se in an Alzheimer-like sporadic dementia animal model. Male mice were divided into 4 groups: control, Aβ, Se, and Aβ + Se. Single administration of Aβ peptide (fragments 25–35; 3 nmol/3 μL or distilled water was administered via intracerebroventricular (i.c.v. injection. Selenofuranoside (5 mg/kg or vehicle (canola oil was administered orally 30 min before Aβ and for 7 subsequent days. Memory was tested through the Morris water maze (MWM and step-down passive-avoidance (SDPA tests. Antioxidant defenses along with reactive species (RS were assessed. Inflammatory cytokines levels and AChE activity were measured. SOD activity was inhibited in the Aβ group whereas RS were increased. AChE activity, GSH, and IL-6 levels were increased in the Aβ group. These changes were reflected in impaired cognition and memory loss, observed in both behavioral tests. Se compound was able to protect against memory loss in mice in both behavioral tests. SOD and AChE activities as well as RS and IL-6 levels were also protected by Se administration. Therefore, Se is promising for further studies.

  1. Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.

    Science.gov (United States)

    Shrivastava, Sushant K; Srivastava, Pavan; Upendra, T V R; Tripathi, Prabhash Nath; Sinha, Saurabh K

    2017-02-15

    Series of some 3,5-dimethoxy-N-methylenebenzenamine and 4-(methyleneamino)benzoic acid derivatives comprising of N-methylenebenzenamine nucleus were designed, synthesized, characterized, and assessed for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory, and antioxidant activity thereby improving learning and memory in rats. The IC 50 values of all the compound along with standard were determined on AChE and BChE enzyme. The free radical scavenging activity was also assessed by in vitro DPPH (2,2-diphenyl-1-picryl-hydrazyl) and hydrogen peroxide radical scavenging assay. The selective inhibitions of all compounds were observed against AChE in comparison with standard donepezil. The enzyme kinetic study of the most active compound 4 indicated uncompetitive AChE inhibition. The docking studies of compound 4 exhibited the worthy interaction on active-site gorge residues Phe330 and Trp279 responsible for its high affinity towards AChE, whereas lacking of the BChE inhibition was observed due to a wider gorge binding site and absence of important aromatic amino acids interactions. The ex vivo study confirmed AChE inhibition abilities of compound 4 at brain site. Further, a considerable decrease in escape latency period of the compound was observed in comparison with standard donepezil through in vivo Spatial Reference Memory (SRM) and Spatial Working Memory (SWM) models which showed the cognition-enhancing potential of compound 4. The in vivo reduced glutathione (GSH) estimation on rat brain tissue homogenate was also performed to evaluate free radical scavenging activity substantiated the antioxidant activity in learning and memory. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin.

    Science.gov (United States)

    Ihara, Makoto; Okajima, Toshihide; Yamashita, Atsuko; Oda, Takuma; Hirata, Koichi; Nishiwaki, Hisashi; Morimoto, Takako; Akamatsu, Miki; Ashikawa, Yuji; Kuroda, Shun'ichi; Mega, Ryosuke; Kuramitsu, Seiki; Sattelle, David B; Matsuda, Kazuhiko

    2008-06-01

    Neonicotinoid insecticides, which act on nicotinic acetylcholine receptors (nAChRs) in a variety of ways, have extremely low mammalian toxicity, yet the molecular basis of such actions is poorly understood. To elucidate the molecular basis for nAChR-neonicotinoid interactions, a surrogate protein, acetylcholine binding protein from Lymnaea stagnalis (Ls-AChBP) was crystallized in complex with neonicotinoid insecticides imidacloprid (IMI) or clothianidin (CTD). The crystal structures suggested that the guanidine moiety of IMI and CTD stacks with Tyr185, while the nitro group of IMI but not of CTD makes a hydrogen bond with Gln55. IMI showed higher binding affinity for Ls-AChBP than that of CTD, consistent with weaker CH-pi interactions in the Ls-AChBP-CTD complex than in the Ls-AChBP-IMI complex and the lack of the nitro group-Gln55 hydrogen bond in CTD. Yet, the NH at position 1 of CTD makes a hydrogen bond with the backbone carbonyl of Trp143, offering an explanation for the diverse actions of neonicotinoids on nAChRs.

  3. 大白鼠海马神经元NOS与AChE活性的研究%Study on the NOS and AChE Activity in the Hippocampus Neurons of Rat

    Institute of Scientific and Technical Information of China (English)

    夏保芦; 杨荣; 杨友华; 杨敏; 黄丹

    2005-01-01

    目的:观察大白鼠海马不同亚区一氧化氮合酶(NOS)与乙酰胆碱酯酶(AChE)阳性神经元的活性.方法:分别采用还原型尼克酰胺嘌呤二核苷酸脱氢酶(NADPH-d)和乙酰胆碱酯酶(AChE)组织化学方法对大白鼠海马不同亚区NOS和AChE阳性神经元的分布以及活性进行研究.结果:海马不同亚区均含有NOS和AChE阳性神经元,其中CA2区NOS呈强阳性反应,CA3区AChE呈强阳性反应.结论:实验表明,NOS和AChE阳性神经元广泛分布于大白鼠海马不同亚区,为进一步探讨海马的学习记忆功能机制提供了形态学佐证.

  4. Effects of EGCG and Chlorpyrifos on the Mortality, AChE and GSH of Adult Zebrafish: Independent and Combination

    Science.gov (United States)

    Zhang, Rong; Zhang, Jian; Gao, Qian; Guo, Nichun

    2018-01-01

    Chlorpyrifos is a neurotoxic agent and also causes oxidative stress in the body. EGCG is a typical strong antioxidant and has been reported to be neuroprotective. Our study investigated the mortality, the activity of acetylcholinesterase (AChE) in the brain and glutathione (GSH) in the liver of the adult Zebrafish in present of Chlorpyrifos and EGCG independent and combination. The results indicated that after the addition of EGCG, the mortality of zebrafish induced by Chlorpyrifos was reduced and the activity of AChE and glutathione (GSH) inhibited by Chlorpyrifos in zebrafish was significantly increased, which demonstrated that EGCG inhibited the toxicity Chlorpyrifos to zebrafish. The inhibition was dependent on the concentration of EGCG and Chlorpyrifos, which was not shown a gradual change trend but a complex situation.

  5. Common SAR Derived from Linear and Non-linear QSAR Studies on AChE Inhibitors used in the Treatment of Alzheimer's Disease.

    Science.gov (United States)

    Pulikkal, Babitha Pallikkara; Marunnan, Sahila Mohammed; Bandaru, Srinivas; Yadav, Mukesh; Nayarisseri, Anuraj; Sureshkumar, Sivanpillai

    2017-11-14

    Deficits in cholinergic neurotransmission due to the degeneration of cholinergic neurons in the brain are believed to be one of the major causes of the memory impairments associated with AD. Targeting acetyl cholinesterase (AChE) surfaced as a potential therapeutic target in the treatment of Alzheimer's disease. The present study is pursued to develop quantitative structure activity relationship (QSAR) models to determine chemical descriptors responsible for AChE activity. Two different sets of AChE inhibitors, dataset-I (30 compounds) and dataset-II (20 compounds) were investigated through MLR aided linear and SVM aided non-linear QSAR models. The obtained QSAR models were found statistically fit, stable and predictive on validation scales. These QSAR models were further investigated for their common structure-activity relationship in terms of overlapping molecular descriptors selection. Atomic mass weighted 3D Morse descriptors (MATS5m) and Radial Distribution Function (RDF045m) descriptors were found in common SAR for both the datasets. Electronegativity weighted (MATS5e, HATSe, and Mor17e) descriptors have also been identified in regulative roles towards endpoint values of dataset-I and dataset-II. The common SAR identified in these linear and non-linear QSAR models could be utilized to design novel inhibitors of AChE with improved biological activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.

    Directory of Open Access Journals (Sweden)

    Azadeh Shahsavar

    Full Text Available Nicotinic acetylcholine receptors (nAChRs are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed, activated (open, and desensitized (closed states. The acetylcholine binding protein (AChBP is a structural homologue of the extracellular ligand-binding domain of nAChRs. In previous studies, the degree of the C-loop radial extension of AChBP has been assigned to different conformational states of nAChRs. It has been suggested that a closed C-loop is preferred for the active conformation of nAChRs in complex with agonists whereas an open C-loop reflects an antagonist-bound (closed state. In this work, we have determined the crystal structure of AChBP from the water snail Lymnaea stagnalis (Ls in complex with dihydro-β-erythroidine (DHβE, which is a potent competitive antagonist of nAChRs. The structure reveals that binding of DHβE to AChBP imposes closure of the C-loop as agonists, but also a shift perpendicular to previously observed C-loop movements. These observations suggest that DHβE may antagonize the receptor via a different mechanism compared to prototypical antagonists and toxins.

  7. Chlorpyrifos and Malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity

    Science.gov (United States)

    Richendrfer, Holly; Creton, Robbert

    2015-01-01

    Organophosphates, a type of neurotoxicant pesticide, are used globally for the treatment of pests on croplands and are therefore found in a large number of conventional foods. These pesticides are harmful and potentially deadly if ingested or inhaled in large quantities by causing a significant reduction in acetylcholinesterase (AChE) activity in the central and peripheral nervous system. However, much less is known about the effects of exposure to small quantities of the pesticides on neural systems and behavior during development. In the current study we used zebrafish larvae in order to determine the effects of two of the most widely used organophosphates, chlorpyrifos and malathion, on zebrafish behavior and AChE activity. Embryos and larvae were exposed to the organophosphates during different time points in development and then tested at 5 days post-fertilization for behavioral, neurodevelopmental and AChE abnormalities. The results of the study indicate that chlorpyrifos and malathion cause opposing behaviors in the larvae such as swim speed (hypoactivity vs. hyperactivity) and rest. Additionally, the pesticides affect only certain behaviors, such as thigmotaxis, during specific time points in development that are unrelated to changes in AChE activity. Larvae treated with malathion but not chlorpyrifos also had significantly smaller forebrain and hindbrain regions compared to controls by 5 days post-fertilization. We conclude that exposure to very low concentrations of organophosphate pesticides during development cause abnormalities in behavior and brain size. PMID:25983063

  8. Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity.

    Science.gov (United States)

    Richendrfer, Holly; Creton, Robbert

    2015-07-01

    Organophosphates, a type of neurotoxicant pesticide, are used globally for the treatment of pests on croplands and are therefore found in a large number of conventional foods. These pesticides are harmful and potentially deadly if ingested or inhaled in large quantities by causing a significant reduction in acetylcholinesterase (AChE) activity in the central and peripheral nervous system. However, much less is known about the effects of exposure to small quantities of the pesticides on neural systems and behavior during development. In the current study we used zebrafish larvae in order to determine the effects of two of the most widely used organophosphates, chlorpyrifos and malathion, on zebrafish behavior and AChE activity. Embryos and larvae were exposed to the organophosphates during different time points in development and then tested at 5 days post-fertilization for behavioral, neurodevelopmental and AChE abnormalities. The results of the study indicate that chlorpyrifos and malathion cause opposing behaviors in the larvae such as swim speed (hypoactivity vs. hyperactivity) and rest. Additionally, the pesticides affect only certain behaviors, such as thigmotaxis, during specific time points in development that are unrelated to changes in AChE activity. Larvae treated with malathion but not chlorpyrifos also had significantly smaller forebrain and hindbrain regions compared to controls by 5 days post-fertilization. We conclude that exposure to very low concentrations of organophosphate pesticides during development cause abnormalities in behavior and brain size. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Deposition of a-C:H films on a nanotrench pattern by bipolar PBII and D

    International Nuclear Information System (INIS)

    Hirata, Yuki; Nakahara, Yuya; Nagato, Keisuke; Choi, Junho

    2016-01-01

    In this study, hydrogenated amorphous carbon (a-C:H) films were deposited on a nanotrench pattern (300 nm pitch, aspect ratio: 2.0) by bipolar-type plasma based ion implantation and deposition technique (bipolar PBII and D), and the effects of bipolar pulse on the film properties were investigated. Moreover, the behaviour of ions and radicals surrounding the nanotrench was analyzed to clarify the coating mechanism and properties of the a-C:H films on the nanotrench. Further, thermal nanoimprint lithography was carried out using the nanotrench pattern coated with a-C:H films as the mold, and the mold release properties were evaluated. All nanotrench surfaces were successfully coated with the a-C:H films, but the film thickness on the top, sidewall, and bottom surfaces of the trench were not uniform. The surface roughness of the a-C:H films was found to decrease at a higher positive voltage; this happens due to the higher electron temperature around the nanotrench because of the surface migration of plasma particles arrived on the trench. The effects of the negative voltage on the behaviour of ions and radicals near the sidewall of the nanotrench are quite similar to those near the microtrench reported previously (Park et al 2014 J. Phys. D: Appl. Phys . 47 335306). However, the positive pulse voltage was also found to affect the behaviour of ions and radicals near the sidewall surface. The incident angles of ions on the sidewall surface increased with the positive pulse voltage because the energy of incoming ions on the trench decreases with increasing positive voltage. Moreover, the incident ion flux on the sidewall is affected by the positive voltage history. Further, the radical flux decreases with increasing positive voltage. It can be concluded that a higher positive voltage at a lower negative voltage condition is good to obtain better film properties and higher film thickness on the sidewall surface. Pattern transfer properties for the nanoimprint formed by

  10. Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs.

    Directory of Open Access Journals (Sweden)

    Nikita Abraham

    Full Text Available Nicotinic acetylcholine receptors (nAChR are ligand gated ion channels, identified as therapeutic targets for a range of human diseases. Drug design for nAChR related disorders is increasingly using structure-based approaches. Many of these structural insights for therapeutic lead development have been obtained from co-crystal structures of nAChR agonists and antagonists with the acetylcholine binding protein (AChBP. AChBP is a water soluble, structural and functional homolog of the extracellular, ligand-binding domain of nAChRs. Currently, AChBPs are recombinantly expressed in eukaryotic expression systems for structural and biophysical studies. Here, we report the establishment of an Escherichia coli (E. coli expression system that significantly reduces the cost and time of production compared to the existing expression systems. E. coli can efficiently express unglycosylated AChBP for crystallography and makes the expression of isotopically labelled forms feasible for NMR. We used a pHUE vector containing an N-terminal His-tagged ubiquitin fusion protein to facilitate AChBP expression in the soluble fractions, and thus avoid the need to recover protein from inclusion bodies. The purified protein yield obtained from the E. coli expression system is comparable to that obtained from existing AChBP expression systems. E. coli expressed AChBP bound nAChR agonists and antagonists with affinities matching those previously reported. Thus, the E. coli expression system significantly simplifies the expression and purification of functional AChBP for structural and biophysical studies.

  11. Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin.

    Science.gov (United States)

    Liu, Hao-Ran; Men, Xue; Gao, Xiao-Hui; Liu, Lin-Bo; Fan, Hao-Qun; Xia, Xin-Hua; Wang, Qiu-An

    2018-03-01

    Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from naringin. The bioactivity evaluation revealed that most of them exhibited moderate or potent acetylcholinesterase (AChE) inhibitory activity. Among them, compound 7 (IC 50 for AChE = 0.82 ± 0.08 μmol•L -1 , IC 50 for BuChE = 46.30 ± 3.26 μmol•L -1 ) showed a potent activity and high selectivity compared with the positive control Rivastigmine (IC 50 for AChE = 10.54 ± 0.86 μmol•L -1 , IC 50 for BuChE = 0.26 ± 0.08 μmol•L -1 ). The kinetic study suggested that compound 7 bind to AChE with mix-type inhibitory profile. Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20.

  12. Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle

    Directory of Open Access Journals (Sweden)

    Andrzej P. Herman

    2017-01-01

    Full Text Available The study was designed to test the hypothesis that the inhibition of acetylcholinesterase (AChE activity at the periphery by Neostigmine (0.5 mg/animal will be sufficient to prevent inflammatory dependent suppression of the gonadotropin-releasing hormone (GnRH/luteinising hormone (LH secretion in ewes in the follicular phase of the estrous cycle, and this effect will be comparable with the systemic AChE inhibitor, Donepezil (2.5 mg/animal. An immune/inflammatory challenge was induced by peripheral administration of lipopolysaccharide (LPS; 400 ng/kg. Peripheral treatment with Donepezil and Neostigmine prevented the LPS-induced decrease (P<0.05 in LHβ gene expression in the anterior pituitary gland (AP and in LH release. Moreover, Donepezil completely abolished (P<0.05 the suppressory effect of inflammation on GnRH synthesis in the preoptic area, when pretreatment with Neostigmine reduced (P<0.05 the decrease in GnRH content in this hypothalamic structure. Moreover, administration of both AChE inhibitors diminished (P<0.05 the inhibitory effect of LPS treatment on the expression of GnRH receptor in the AP. Our study shows that inflammatory dependent changes in the GnRH/LH secretion may be eliminated or reduced by AChE inhibitors suppressing inflammatory reaction only at the periphery such as Neostigmine, without the need for interfering in the central nervous system.

  13. Higher Education

    Science.gov (United States)

    & Development (LDRD) National Security Education Center (NSEC) Office of Science Programs Richard P Databases National Security Education Center (NSEC) Center for Nonlinear Studies Engineering Institute Scholarships STEM Education Programs Teachers (K-12) Students (K-12) Higher Education Regional Education

  14. Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes

    International Nuclear Information System (INIS)

    Wang Min; Wang Jiquan; Gao Mingzhang; Zheng Qihuang

    2008-01-01

    Rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, and is used for the treatment of AChE- and BChE-related diseases such as brain Alzheimer's disease and cardiovascular disease. New carbon-11 labeled conformationally restricted rivastigmine analogues radiolabeled quaternary ammonium triflate salts, (3aR,9bS)-1-[ 11 C]methyl-1-methyl-6-(methylcarbamoyloxy)-2,3,3a,4,5, 9b-hexahy dro-1H-benzo[g]indolium triflate ([ 11 C]8) and (3aR,9bS)-1-[ 11 C]methyl-1-methyl-6-(heptylcarbamoyloxy)-2,3,3a,4,5, 9b-hexahy dro-1H-benzo[g]indolium triflate ([ 11 C]9), were designed and synthesized as potential positron emission tomography (PET) agents for imaging AChE and BChE enzymes. The appropriate precursors were labeled with [ 11 C]CH 3 OTf through N-[ 11 C]methylation, and the target tracers were isolated by solid-phase extraction (SPE) using a cation-exchange CM Sep-Pak cartridge in 40-50% radiochemical yields decay corrected to end of bombardment (EOB), 15-20 min overall synthesis time, and 148-222 GBq/μmol specific activity at EOB

  15. Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain

    DEFF Research Database (Denmark)

    Christensen, Ditte Z; Mikkelsen, Jens D; Hansen, Henrik H

    2010-01-01

    AChR binding sites in several brain regions, particularly in the prefrontal cortex. The alpha7 nAChR agonists SSR180711 and PNU-282987 also increase [(125)I]-BTX binding, suggesting that this is a general consequence of alpha7 nAChR agonism. Interestingly, the alpha7 nAChR positive allosteric modulators PNU......The alpha7 nicotinic acetylcholine receptor (nAChR) is an important target for treatment of cognitive deficits in schizophrenia and Alzheimer's disease. However, the receptor desensitizes rapidly in vitro, which has led to concern regarding its applicability as a clinically relevant drug target....... Here we investigate the effects of repeated agonism on alpha7 nAChR receptor levels and responsiveness in vivo in rats. Using [(125)I]-alpha-bungarotoxin (BTX) autoradiography we show that acute or repeated administration with the selective alpha7 nAChR agonist A-582941 increases the number of alpha7 n...

  16. AChR-specific immunosuppressive therapy of myasthenia gravis.

    Science.gov (United States)

    Luo, Jie; Lindstrom, Jon

    2015-10-15

    Myasthenia gravis (MG) is an organ-specific autoimmune disease characterized by muscle fatigability. In most cases, it is mediated by autoantibodies targeting muscle nicotinic acetylcholine receptors (AChRs) at the neuromuscular junction. Experimental autoimmune myasthenia gravis (EAMG) is an animal model for MG, which is usually induced by immunization with AChR purified from fish electric organ. Pathological autoantibodies to AChRs are directed at the extracellular surface, especially the main immunogenic region (MIR). Current treatments for MG can help many but not all patients. Antigen-specific immunosuppressive therapy for MG that specifically suppresses the autoimmune response without affecting the entire immune system and avoids side effects of general immunosuppression is currently unavailable. Early attempts at antigen-specific immunosuppression for EAMG using AChR extracellular domain sequences that form epitopes for pathological autoantibodies risked provoking autoimmunity rather than suppressing it. We discovered a novel approach to specific immunosuppression of EAMG with a therapeutic vaccine consisting of bacterially-expressed human AChR cytoplasmic domains, which has the potential to specifically suppress MG without danger of causing exacerbation. This approach prevents development of chronic EAMG when initiated immediately after the acute phase of EAMG, and rapidly reverses established chronic EAMG when started during the chronic phase of EAMG. Successfully treated rats exhibited long-term resistance to re-induction of EAMG. In this review we also discuss the current understanding of the mechanisms by which the therapy works. Vaccination with AChR cytoplasmic domains in adjuvant is promising as a safe, antigen-specific, potent, effective, rapidly acting, and long lasting approach to therapy of MG. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors

    Directory of Open Access Journals (Sweden)

    Liu Sijie

    2015-01-01

    Full Text Available The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4 lonic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10μM.

  18. Insect nicotinic acetylcholine receptors (nAChRs): Important amino ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-12-29

    Dec 29, 2008 ... nAChRs within the insect central nervous system has led to the development of insecticides targeting .... binding protein (AChBP), a homopentameric structural and functional homolog of ..... of the honey bee, Apis mellifera.

  19. Acetylcholinesterase Regulates Skeletal In Ovo Development of Chicken Limbs by ACh-Dependent and -Independent Mechanisms.

    Directory of Open Access Journals (Sweden)

    Janine Spieker

    Full Text Available Formation of the vertebrate limb presents an excellent model to analyze a non-neuronal cholinergic system (NNCS. Here, we first analyzed the expression of acetylcholinesterase (AChE by IHC and of choline acetyltransferase (ChAT by ISH in developing embryonic chicken limbs (stages HH17-37. AChE outlined formation of bones, being strongest at their distal tips, and later also marked areas of cell death. At onset, AChE and ChAT were elevated in two organizing centers of the limb anlage, the apical ectodermal ridge (AER and zone of polarizing activity (ZPA, respectively. Thereby ChAT was expressed shortly after AChE, thus strongly supporting a leading role of AChE in limb formation. Then, we conducted loss-of-function studies via unilateral implantation of beads into chicken limb anlagen, which were soaked in cholinergic components. After varying periods, the formation of cartilage matrix and of mineralizing bones was followed by Alcian blue (AB and Alizarin red (AR stainings, respectively. Both acetylcholine (ACh- and ChAT-soaked beads accelerated bone formation in ovo. Notably, inhibition of AChE by BW284c51, or by the monoclonal antibody MAB304 delayed cartilage formation. Since bead inhibition of BChE was mostly ineffective, an ACh-independent action during BW284c51 and MAB304 inhibition was indicated, which possibly could be due to an enzymatic side activity of AChE. In conclusion, skeletogenesis in chick is regulated by an ACh-dependent cholinergic system, but to some extent also by an ACh-independent aspect of the AChE protein.

  20. Globalisation and Higher Education

    NARCIS (Netherlands)

    Marginson, Simon; van der Wende, Marijk

    2007-01-01

    Economic and cultural globalisation has ushered in a new era in higher education. Higher education was always more internationally open than most sectors because of its immersion in knowledge, which never showed much respect for juridical boundaries. In global knowledge economies, higher education

  1. Targeting α4β2 nAChRs in CNS disorders: Perspectives on positive allosteric modulation as a therapeutic approach

    DEFF Research Database (Denmark)

    Grupe, Morten; Grunnet, Morten; Bastlund, Jesper F.

    2015-01-01

    The nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels broadly involved in regulating neurotransmission in the central nervous system (CNS) by conducting cation currents through the membrane of neurons. Many different nAChR subtypes exist with each their functional character......The nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels broadly involved in regulating neurotransmission in the central nervous system (CNS) by conducting cation currents through the membrane of neurons. Many different nAChR subtypes exist with each their functional...... characteristics, expression pattern and pharmacological profile. The focus of the present MiniReview is on the heteromeric α4β2 nAChR, as activity at this subtype contributes to cognitive functioning through interactions with multiple neurotransmitter systems and is implicated in various CNS disorders...... and temporal aspects of neurotransmission as well as higher subtype selectivity, hypothetically resulting in high clinical efficacy with minimal adverse effects. In this MiniReview, we describe the currently identified compounds, which potentiate the effects of agonists at the α4β2 nAChR. The potential...

  2. Dual Inhibition of AChE and BChE with the C-5 Substituted Derivative of Meldrum’s Acid: Synthesis, Structure Elucidation, and Molecular Docking Studies

    Directory of Open Access Journals (Sweden)

    Haroon Mehfooz

    2017-07-01

    Full Text Available Alzheimer’s disease (AD lies in the category of those diseases which are still posing challenges to medicinal chemists, and the search for super-effective drugs for the treatment of AD is a work in progress. The inhibition of cholinesterase is considered a viable strategy to enhance the level of acetylcholine in the brain. The C-5 substituted derivative of Meldrum’s acid was synthesized and screened against acetylcholinesterase (AChE and butyrylcholinesterase (BChE enzyme inhibition activity. The simple and unique structure of synthesized derivative 3 was found to be good for the dual inhibition of both enzymes (AChE and BChE. 2,2-Dimethyl-5-(([2-(trifluoromethyl phenyl]aminomethylidene-1,3-dioxane-4,6-dione (3 showed significant inhibition against AChE, with an IC50 value of 1.13 ± 0.03 µ M (Standard Neostigmine 22.2 ± 3.2 µM, and moderate inhibition against BChE, with an IC50 value of 2.12 ± 1.22 µM (Standard Neostigmine 49.6 ± 6.11 µM. The structural insights reveal that compound 3 possesses intriguing reactive groups, which can potentially evoke the non-covalent interactions and possibly assist by binding in the active site of the target protein. Docking simulations revealed that the compound 3 showed binding inside the active site gorges of both AChE and BChE. An excellent agreement was obtained, as the best docked poses showed important binding features mostly based on interactions due to oxygen atoms and the aromatic moieties of the compound. The docking computations coupled with the experimental findings ascertained that the compound 3 can serve as a scaffold for the dual inhibitors of the human acetylcholine esterases.

  3. Perspectives on Transnational Higher Education: A View from Cooperative Education%Perspectives on Transnational Higher Education:A View from Cooperative Education

    Institute of Scientific and Technical Information of China (English)

    MENG Jun

    2017-01-01

    The rapid development of transnational higher education among the world leaves theoretical and practical room for study on educational globalization in the age.In China,transnational higher education is mostly manifested through issues and approaches on Sino-Foreign Cooperative education,but comparatively speaking,cooperative education that is one of educational patterns has been examined and applied widely in western countries.This study offers a systematically review on transnational higher education and cooperative education specifically on its origins and practice,which demonstrate the usefulness improving development of higher education in China.

  4. MRI of hyperacute stroke in the AChA territory

    Energy Technology Data Exchange (ETDEWEB)

    Hamoir, Xavier L.; Grandin, Cecile B.; Cosnard, Guy; Duprez, Thierry [Department of Medical Imaging, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels (Belgium); Peeters, Andre [Department of Neurology, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels (Belgium); Robert, Annie [Department of Epidemiology, Biostatistics Unit of the Public Health School, Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels (Belgium)

    2004-03-01

    The purpose of our study was to derive from the anatomical literature an easy-to-use map of the brain areas supplied by the anterior choroidal artery (AChA) and to assess the correspondence between damage within the putative AChA areas and clinical symptoms. A thorough review of the literature led to the recognition of 16 anatomical areas which could be delineated on routine diffusion-weighted MR images. A database of 138 consecutive ischemic stroke patients examined with MRI less than 6 h after symptoms onset was thereafter processed in a retrospective way. Patients presenting with at least one damaged AChA area were selected so as to assess the prevalence of AChA infarction and the clinical correlates of the condition. Fifteen patients (11%) had at least one damaged AChA area. Only two of them had ''pure'' AChA-restricted infarction. Contralateral hemiparesis and contralateral hemianesthesia were best predicted by lesions within the tail of the caudate nucleus with a sensitivity of 87% and 83%, respectively. Homonymous hemianopsia best correlated with lesions within the posterior limb of the internal capsule and within the retrolenticular part of the internal capsule, with a sensitivity of 100% and a specificity of 70% for both areas. We concluded that the clinical-radiological correlations did not match the neurophysiological standards, thereby highlighting the limitation of this study, which involved a cohort of acute stroke patients recruited from clinical practice and investigated the clinical impact of these brain lesions, even when documented with the most sensitive imaging modality. (orig.)

  5. MRI of hyperacute stroke in the AChA territory

    International Nuclear Information System (INIS)

    Hamoir, Xavier L.; Grandin, Cecile B.; Cosnard, Guy; Duprez, Thierry; Peeters, Andre; Robert, Annie

    2004-01-01

    The purpose of our study was to derive from the anatomical literature an easy-to-use map of the brain areas supplied by the anterior choroidal artery (AChA) and to assess the correspondence between damage within the putative AChA areas and clinical symptoms. A thorough review of the literature led to the recognition of 16 anatomical areas which could be delineated on routine diffusion-weighted MR images. A database of 138 consecutive ischemic stroke patients examined with MRI less than 6 h after symptoms onset was thereafter processed in a retrospective way. Patients presenting with at least one damaged AChA area were selected so as to assess the prevalence of AChA infarction and the clinical correlates of the condition. Fifteen patients (11%) had at least one damaged AChA area. Only two of them had ''pure'' AChA-restricted infarction. Contralateral hemiparesis and contralateral hemianesthesia were best predicted by lesions within the tail of the caudate nucleus with a sensitivity of 87% and 83%, respectively. Homonymous hemianopsia best correlated with lesions within the posterior limb of the internal capsule and within the retrolenticular part of the internal capsule, with a sensitivity of 100% and a specificity of 70% for both areas. We concluded that the clinical-radiological correlations did not match the neurophysiological standards, thereby highlighting the limitation of this study, which involved a cohort of acute stroke patients recruited from clinical practice and investigated the clinical impact of these brain lesions, even when documented with the most sensitive imaging modality. (orig.)

  6. Accessibility of higher education: the right to higher education in comparative approach

    OpenAIRE

    Pūraitė, Aurelija

    2011-01-01

    At present there is an unprecedented demand for and a great diversification in higher education, as well as an increased awareness of its vital importance for socio-cultural and economic development. The complexity of the right to education is especially at issue while discussing the right to higher education, which on a national level is non-compulsory, even though the number of people who have acquired higher education during the second half of the twentieth century has tripled. Therefore t...

  7. Educational Fever and South Korean Higher Education

    Directory of Open Access Journals (Sweden)

    Jeong-Kyu Lee

    2006-05-01

    Full Text Available This paper examines the influence of educational fever on the development of the Republic of Korea education and economy in the context of the cultural history of this country. In order to examine this study, the author explains the concept of educational fever and discusses the relation between Confucianism and education zeal. Educational fever and human capitalization in South Korean higher education are analyzed from a comparative viewpoint. The study evaluates the effects and problems of education fever this country’s current higher education, and it concludes that Koreans’ educational fever has been a core factor by which to achieve the development of the national economy as well as the rapid expansion of higher education.

  8. Quality of Higher Education

    DEFF Research Database (Denmark)

    Zou, Yihuan

    is about constructing a more inclusive understanding of quality in higher education through combining the macro, meso and micro levels, i.e. from the perspectives of national policy, higher education institutions as organizations in society, individual teaching staff and students. It covers both......Quality in higher education was not invented in recent decades – universities have always possessed mechanisms for assuring the quality of their work. The rising concern over quality is closely related to the changes in higher education and its social context. Among others, the most conspicuous...... changes are the massive expansion, diversification and increased cost in higher education, and new mechanisms of accountability initiated by the state. With these changes the traditional internally enacted academic quality-keeping has been given an important external dimension – quality assurance, which...

  9. Revitalizing Higher Education. Issues in Higher Education, Volume 3. First Edition.

    Science.gov (United States)

    Salmi, Jamil, Ed.; Verspoor, Adriaan M., Ed.

    This volume contains 13 papers on experiences with reform and innovation in higher education and their implications for developing countries. Four themes are highlighted: higher education and development, performance assessment, sustainable financing, and effectiveness in governance and management. The papers include: "Introduction:…

  10. Perceived Value of University-Based Continuing Education Leadership Development Programs for Administrators

    Science.gov (United States)

    Stone, Geri L.; Major, Claire H.

    2014-01-01

    This quantitative study, which involved development of a Value Creation Survey, examined the perceived value of leadership development programs (LDPs) provided by continuing higher education for administrators in colleges and universities. Participants were administrators at Association for Continuing Higher Education (ACHE) member institutions.…

  11. Comparative functional expression of nAChR subtypes in rodent DRG neurons.

    Science.gov (United States)

    Smith, Nathan J; Hone, Arik J; Memon, Tosifa; Bossi, Simon; Smith, Thomas E; McIntosh, J Michael; Olivera, Baldomero M; Teichert, Russell W

    2013-01-01

    We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations of dissociated rat and mouse lumbar dorsal root ganglion (DRG) neurons by calcium imaging. By this experimental approach, it is possible to investigate the functional expression of multiple receptor and ion-channel subtypes across more than 100 neuronal and glial cells simultaneously. Based on nAChR expression, DRG neurons could be divided into four subclasses: (1) neurons that express predominantly α3β4 and α6β4 nAChRs; (2) neurons that express predominantly α7 nAChRs; (3) neurons that express a combination of α3β4/α6β4 and α7 nAChRs; and (4) neurons that do not express nAChRs. In this comparative study, the same four neuronal subclasses were observed in mouse and rat DRG. However, the expression frequency differed between species: substantially more rat DRG neurons were in the first three subclasses than mouse DRG neurons, at all developmental time points tested in our study. Approximately 70-80% of rat DRG neurons expressed functional nAChRs, in contrast to only ~15-30% of mouse DRG neurons. Our study also demonstrated functional coupling between nAChRs, voltage-gated calcium channels, and mitochondrial Ca(2) (+) transport in discrete subsets of DRG neurons. In contrast to the expression of nAChRs in DRG neurons, we demonstrated that a subset of non-neuronal DRG cells expressed muscarinic acetylcholine receptors and not nAChRs. The general approach to comparative cellular neurobiology outlined in this paper has the potential to better integrate molecular and systems neuroscience by uncovering the spectrum of neuronal subclasses present in a given cell population and the functionally integrated signaling components expressed in each subclass.

  12. Study on the Highly Sensitive AChE Electrode Based on Multiwalled Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Shuping Zhang

    2014-01-01

    Full Text Available Using chitosan (CS as carrier, the method named layer-by-layer (LBL self-assembly modification to modify the glassy carbon electrode (GCE with multiwalled carbon nanotubes (MWNTs and acetylcholine esterase (AChE was proposed to prepare the acetylcholine esterase electrode with high sensitivity and stability. The modified electrode was used to detect pesticide of aldicarb, and the enzyme inhibition rate of the electrode showed good linearity with pesticide concentrations in the range of 10−10 g·L−1 to 10−3 g·L−1. The detection limit was 10−11 g·L−1. The modified electrode was also used to detect the actual sample, and the recovery rate range was from 97.72% to 107.15%, which could meet the rapid testing need of the aldicarb residue. After being stored in the phosphate buffer solution (PBS in 4°C for 30 days, the modified electrode showed good stability with the response current that was 80% of the original current.

  13. Competitiveness - higher education

    Directory of Open Access Journals (Sweden)

    Labas Istvan

    2016-03-01

    Full Text Available Involvement of European Union plays an important role in the areas of education and training equally. The member states are responsible for organizing and operating their education and training systems themselves. And, EU policy is aimed at supporting the efforts of member states and trying to find solutions for the common challenges which appear. In order to make our future sustainable maximally; the key to it lies in education. The highly qualified workforce is the key to development, advancement and innovation of the world. Nowadays, the competitiveness of higher education institutions has become more and more appreciated in the national economy. In recent years, the frameworks of operation of higher education systems have gone through a total transformation. The number of applying students is continuously decreasing in some European countries therefore only those institutions can “survive” this shortfall, which are able to minimize the loss of the number of students. In this process, the factors forming the competitiveness of these budgetary institutions play an important role from the point of view of survival. The more competitive a higher education institution is, the greater the chance is that the students would like to continue their studies there and thus this institution will have a greater chance for the survival in the future, compared to ones lagging behind in the competition. Aim of our treatise prepared is to present the current situation and main data of the EU higher education and we examine the performance of higher education: to what extent it fulfils the strategy for smart, sustainable and inclusive growth which is worded in the framework of Europe 2020 programme. The treatise is based on analysis of statistical data.

  14. Vocational Education and the Binary Higher Education System in the Netherlands: Higher Education Symbiosis or Vocational Education Dichotomy?

    Science.gov (United States)

    van Houten, Maarten Matheus

    2018-01-01

    The Netherlands has a binary higher education system in which academic education and higher professional education at EQF levels 5-8 co-exist. There is also secondary vocational education at EQF levels 1 up to 4. In this paper, I analyse policy documents resulting from the Bologna Process and argue that under neo-liberal conditions, higher…

  15. Fabrication of a Highly-sensitive Acetylcholine Sensor Based on AChOx Immobilized Smart-chips

    Directory of Open Access Journals (Sweden)

    M. M. RAHMAN

    2011-03-01

    Full Text Available Acetylcholine (ACh sensor based on acetylcholine oxidase (AChOx on EDC activated thioglycolic acid self-assembled monolayer (TGA-SAM using smart-chip has been developed. The simple cyclic voltammetry (CV, at 0.1 V/s technique is performed in total investigation, where 0.5M K3Fe(CN6 is utilized as a standard mediator in phosphate buffer solution (PBS, 0.1M. The ACh sensor exhibited a lower detection limit (DL, 0.1392 ± 0.005 nM, a wide linear dynamic range (LDR, 1.0 nM to 1.0 mM, good linearity (R=0.9951, and higher sensitivity (7.3543 ± 0.2 μAμM-1cm-2, and required small sample volume (70.0 μL as well as good stability and reproducibility. The smart-chip system employed a simple and efficient approach to the immobilization of enzymes onto active sensitive surface, which can enhance sensor performances to a large group of bio-molecules for wide range of biomedical applications in health care fields.

  16. Quality of higher education: organisational or educational?

    DEFF Research Database (Denmark)

    Zou, Yihuan; Du, Xiangyun; Rasmussen, Palle

    2012-01-01

    Based on a study of Chinese university self-evaluation reports, this paper argues that higher education institutions are trying to manage the tensions between educational and organisational quality and the increasing and worldwide concerns about quality assurance. After 30 years of dramatic...... remain an important basis for external review. In an attempt to examine the institutional understanding of quality in higher education, the authors conducted a content analysis study of 53 self-evaluation reports written by a wide range of higher education institutions in China. This study concludes...... educational reform, China has established a nationwide evaluation system for assessing its higher education institutions. This comprehensive system includes a series of procedures for both internal self-evaluation and external peer reviewing, among which self-evaluation reports prepared by each institution...

  17. The Growth of Higher Educators for Social Justice: Collaborative Professional Development in Higher Education

    Directory of Open Access Journals (Sweden)

    Molly K. Ness, PhD

    2010-08-01

    Full Text Available In this article, we investigate what happened when, contrary to the typical isolation of faculty in higher education, a group of higher educators from various disciplines in a graduate school of education met regularly to discuss issues related to our teaching and social justice. More specifically, we explored the following research question: How does collaboration among higher educators from various disciplines shape their beliefs and practices of teaching for social justice? Over three years of collaboration and conversation, not only did we expand our own knowledge and understandings of notions of social justice, but we began to take important steps towards increasing our social justice actions in our teaching. This article explores our efforts to create a self-directed professional development group of higher educators and provides suggestions for similarly interested higher educators.

  18. Higher Education in California

    Science.gov (United States)

    Public Policy Institute of California, 2016

    2016-01-01

    Higher education enhances Californians' lives and contributes to the state's economic growth. But population and education trends suggest that California is facing a large shortfall of college graduates. Addressing this short­fall will require strong gains for groups that have been historically under­represented in higher education. Substantial…

  19. Higher Education Systems 3.0: Harnessing Systemness, Delivering Performance. Critical Issues in Higher Education

    Science.gov (United States)

    Lane, Jason E., Ed.; Johnstone, D. Bruce, Ed.

    2013-01-01

    This thought-provoking volume brings together scholars and system leaders to analyze some of the most pressing and complex issues now facing higher education systems and society. Higher Education Systems 3.0 focuses on the remaking of higher education coordination in an era of increased accountability, greater calls for productivity, and…

  20. ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.

    Science.gov (United States)

    Poppi, Lauren A; Tabatabaee, Hessam; Drury, Hannah R; Jobling, Phillip; Callister, Robert J; Migliaccio, Americo A; Jordan, Paivi M; Holt, Joseph C; Rabbitt, Richard D; Lim, Rebecca; Brichta, Alan M

    2018-01-01

    In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent discharge and 2) decreases afferent sensitivity to rotational stimuli. Although the cellular mechanisms underlying these two contrasting afferent responses remain obscure, we postulated that the reduction in afferent sensitivity was attributed, in part, to the activation of α9- containing nicotinic acetylcholine (ACh) receptors (α9*nAChRs) and small-conductance potassium channels (SK) in vestibular type II hair cells, as demonstrated in the peripheral vestibular system of other vertebrates. To test this hypothesis, we examined the effects of the predominant EVS neurotransmitter ACh on vestibular type II hair cells from wild-type (wt) and α9-subunit nAChR knockout (α9 -/- ) mice. Immunostaining for choline acetyltransferase revealed there were no obvious gross morphological differences in the peripheral EVS innervation among any of these strains. ACh application onto wt type II hair cells, at resting potentials, produced a fast inward current followed by a slower outward current, resulting in membrane hyperpolarization and decreased membrane resistance. Hyperpolarization and decreased resistance were due to gating of SK channels. Consistent with activation of α9*nAChRs and SK channels, these ACh-sensitive currents were antagonized by the α9*nAChR blocker strychnine and SK blockers apamin and tamapin. Type II hair cells from α9 -/- mice, however, failed to respond to ACh at all. These results confirm the critical importance of α9nAChRs in efferent modulation of mammalian type II vestibular hair cells. Application of exogenous ACh reduces electrical impedance, thereby decreasing type II hair cell sensitivity. NEW & NOTEWORTHY Expression of α9 nicotinic subunit was crucial for fast cholinergic modulation of mammalian vestibular type II hair cells. These findings show a multifaceted

  1. Higher Education

    African Journals Online (AJOL)

    Kunle Amuwo: Higher Education Transformation: A Paradigm Shilt in South Africa? ... ty of such skills, especially at the middle management levels within the higher ... istics and virtues of differentiation and diversity. .... may be forced to close shop for lack of capacity to attract ..... necessarily lead to racial and gender equity,.

  2. Internationalization of Chinese Higher Education

    Science.gov (United States)

    Chen, Linhan; Huang, Danyan

    2013-01-01

    This paper probes into the development of internationalization of higher education in China from ancient times to modern times, including the emergence of international connections in Chinese higher education and the subsequent development of such connections, the further development of internationalization of Chinese higher education, and the…

  3. HigherEd 2.0: Using social media in engineering education

    OpenAIRE

    Berger, Edward

    2014-01-01

    Social media (blogs, wikis, video, and a digital authoring culture) has emerged in the last decade as a dominant feature of the technology landscape, especially for our current generation of digital-native students. Leveraging these tools for higher education in general, and engineering education in particular, should be of immediate and pressing concern for engineering educators. This discussion summarizes the HigherEd 2.0 project, the creative convergence of higher education and “web 2.0” t...

  4. Aging of oxygen and hydrogen plasma discharge treated a-C:H and ta-C coatings

    Energy Technology Data Exchange (ETDEWEB)

    Bachmann, Svenja [Physics of Surfaces, Institute of Materials Science, Technische Universität Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt (Germany); BMW Group, Hufelandstraße 4, 80788 Munich (Germany); Schulze, Marcus [Physics of Surfaces, Institute of Materials Science, Technische Universität Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt (Germany); Center of Smart Interfaces, Technische Universität Darmstadt, Alarich-Weiss-Str. 10, 64287 Darmstadt (Germany); Morasch, Jan [Institute of Materials Science, Technische Universität Darmstadt, Surface Science Division, Jovanka-Bonschits-Straße 2, 64287 Darmstadt (Germany); Hesse, Sabine [Physics of Surfaces, Institute of Materials Science, Technische Universität Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt (Germany); Center of Smart Interfaces, Technische Universität Darmstadt, Alarich-Weiss-Str. 10, 64287 Darmstadt (Germany); Hussein, Laith [Eduard-Zintl-Institut, Department of Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 12, 64287, Darmstadt (Germany); Krell, Lisa; Schnagl, Johann [BMW Group, Hufelandstraße 4, 80788 Munich (Germany); Stark, Robert W. [Physics of Surfaces, Institute of Materials Science, Technische Universität Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt (Germany); Center of Smart Interfaces, Technische Universität Darmstadt, Alarich-Weiss-Str. 10, 64287 Darmstadt (Germany); and others

    2016-05-15

    Highlights: • The water CA of O{sub 2} and H{sub 2} plasma treated a-C:H and ta-C changes from hydrophillic to hydrophobic on aging. • XPS study indicates that the decrease in surface energy of plasma treated a-C:H and ta-C could be due to adsorption of organic component from air. • The COFLFM of O{sub 2} and H{sub 2} plasma treated a-C:H and ta-C decreased upon aging. • The COF of glycerol lubricated ta-C showed no sign of change upon aging. - Abstract: Surface modification with gas plasma is an efficient and easy way to improve the surface energy and the tribological behavior of diamond-like carbon (DLC) coatings, e.g., in biomedical implants or as protective coatings. However, the long-term performance of the plasma treated DLC coatings is not fully clear. We thus studied the long-term stability of two kinds of DLC coatings, namely (a) hydrogenated amorphous carbon (a-C:H) and (b) tetrahedral amorphous carbon (ta-C) treated at different radio frequency (RF) power and time of oxygen (O{sub 2}) and hydrogen (H{sub 2}) plasma. Their surface properties, e.g. surface wettability, structure and tribological behavior, were studied at regular intervals for a period of two months using contact angle goniometer, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), lateral force microscopy (LFM) and ball on disc apparatus. The surface energy of both the coatings decreased upon aging. The higher the RF power and time of treatment, the higher was the hydrophobicity upon aging. XPS analysis showed that the increase in hydrophobicity could be due to adsorption of unavoidable volatile organic components in the atmosphere. The H{sub 2} plasma treated ta-C was capable of rearranging its structural bonds upon aging. The nano-friction measurements by LFM showed that the coefficient of friction of plasma treated a-C:H and ta-C decreased upon aging. The results indicate that the surface properties of plasma treated a‐C:H and ta‐C are not stable on long-term and are

  5. The Didactics of Higher Education Didactics

    DEFF Research Database (Denmark)

    Keiding, Tina Bering; Qvortrup, Ane

    Based on a systematic categorization and analysis of a total of 393 contributions in three journals for research and development in higher education, the paper shows how the scholarship of teaching and learning in higher education (SoTL) over time have produced a didactic pattern. We designate th...... for general didactics and education research. Especially, how the scholarship of teaching and learning in higher education puts itself at the disposal of the on-going didactical professionalization of teachers in higher education.......Based on a systematic categorization and analysis of a total of 393 contributions in three journals for research and development in higher education, the paper shows how the scholarship of teaching and learning in higher education (SoTL) over time have produced a didactic pattern. We designate...... this pattern “The didactics of higher education didactics”. The analytical framework is found in the didactics of Paul Heimann (Die Lehrteoretische Didaktik) and the empirical basis in the abstracts in Higher Education Research & Development, Uniped and Danish Journal for Teaching and Learning in Higher...

  6. Issues in Moroccan Higher Education

    Directory of Open Access Journals (Sweden)

    Mohammed Lazrak

    2017-06-01

    Full Text Available Historically, education has always been the springboard for socio-economic development of nations. Undoubtedly, education proved to be the catalyst of change and the front wagon that drives with it all the other wagons pertaining to other dynamic sectors. In effect, the role of education can be seen to provide pupils with the curriculum and hidden curriculum skills alike; teaching skills that will prepare them physically, mentally and socially for the world of work in later life. In Morocco, the country spends over 26% of its Gross Domestic Product (GDP on education. Unfortunately, though this number is important, Moroccan education (primary, secondary and higher education alike still suffers from the mismatch between the state expenditures on education and the general product in reality. In this article, an attempt is made to touch on some relevant issues pertaining to higher education with special reference to Morocco. First, it provides some tentative definitions, mission and functions of university and higher education. Second, it gives a historical sketch of the major reforms that took place in Morocco as well as the major changes pertaining to these reforms respectively. Third, it provides a general overview of the history of higher education in Morocco, it also tackles an issue related to governance in higher education which is cost sharing. Fourth, it delves into the history of English Language Teaching (ELT, lists some characteristics of the English Departments in Morocco. Fifth, it discusses the issue of private vs. public higher education. Last, but not least, it tackles the issue of Brain Drain.

  7. Makerere Journal of Higher Education

    African Journals Online (AJOL)

    Makerere Journal of Higher Education (MAJOHE) is the official publication of ... management and improvement of higher education from an international viewpoint. ... Historical Development of Science and Technology Education in Nigeria: ...

  8. Inclusive Education in Higher Education: Challenges and Opportunities

    Science.gov (United States)

    Moriña, Anabel

    2017-01-01

    Implementing the principles of inclusive education within higher education can be challenging. Inclusive education was originally developed for younger students, prior to its application within higher education. However, as more students with disabilities successfully complete their early schooling, the need to move towards inclusive practices…

  9. Inhibitory effects of psychotropic drugs on the acetylcholine receptor-operated potassium current (IK.ACh) in guinea-pig atrial myocytes.

    Science.gov (United States)

    Okada, Muneyoshi; Watanabe, Shinya; Matada, Takashi; Asao, Yoko; Hamatani, Ramu; Yamawaki, Hideyuki; Hara, Yukio

    2013-01-01

    Influences of psychotropic drugs, six antipsychotics and three antidepressants, on acetylcholine receptor-operated potassium current (IK.ACh) were examined by a whole-cell patch clamp method in freshly isolated guinea-pig atrial myocyte. IK.ACh was induced by a superfusion of carbachol (CCh) or by an intracellular application of guanosine 5'-[thio] triphosphate (GTPγS). To elucidate mechanism for anticholinergic action, IC50 ratio, the ratio of IC50 for GTPγS-activated IK.ACh to CCh-induced IK.ACh, was calculated. Antipsychotics and antidepressants inhibited CCh-induced IK.ACh in a concentration-dependent manner. The IC50 values were as follows; chlorpromazine 0.53 μM, clozapine 0.06 μM, fluphenazine 2.69 μM, haloperidol 2.66 μM, sulpiride 42.3 μM, thioridazine 0.07 μM, amitriptyline 0.03 μM, imipramine 0.22 μM and maprotiline 1.81 μM. The drugs, except for sulpiride, inhibited GTPγS-activated IK.ACh with following IC50 values; chlorpromazine 1.71 μM, clozapine 14.9 μM, fluphenazine 3.55 μM, haloperidol 2.73 μM, thioridazine 1.90 μM, amitriptyline 7.55 μM, imipramine 7.09 μM and maprotiline 5.93 μM. The IC50 ratio for fluphenazine and haloperidol was close to unity. The IC50 ratio for chlorpromazine, clozapine, thioridazine, amitriptyline, imipramine and maprotiline was much higher than unity. The present findings suggest that the psychotropics studied suppress IK.ACh. Chlorpromazine, clozapine, thioridazine, amitriptyline, imipramine, maprotiline and sulpiride are preferentially acting on muscarinic receptor. Fluphenazine and haloperidol may act on G protein and/or potassium channel.

  10. Education Pays, 2010: The Benefits of Higher Education for Individuals and Society. Trends in Higher Education Series

    Science.gov (United States)

    Baum, Sandy; Ma, Jennifer; Payea, Kathleen

    2010-01-01

    Students who attend institutions of higher education obtain a wide range of personal, financial, and other lifelong benefits; likewise, taxpayers and society as a whole derive a multitude of direct and indirect benefits when citizens have access to postsecondary education. Accordingly, uneven rates of participation in higher education across…

  11. A Tax for Higher Education

    Science.gov (United States)

    Blumenstyk, Goldie

    2012-01-01

    Higher education pays off handsomely for society. Yet on a nationwide basis, states' support for higher education per full-time-equivalent student has fallen to just $6,290, the lowest in 15 years. A dedicated source of funds for higher education is problematic. But what if state and federal lawmakers applied the impeccable logic of the gas tax to…

  12. Higher Education, Poverty and Development

    Science.gov (United States)

    Tilak, Jandhyala B. G.

    2010-01-01

    There is a presumption among many policy makers that higher education is not necessary for economic growth and development; it is literacy and basic education and at best secondary education that are argued to be important. Estimates of internal rate of return contributed to strengthening of such a presumption. Accordingly, higher education has…

  13. Ethnographic Evaluation of Entrepreneurship Education in Higher Education

    DEFF Research Database (Denmark)

    Robinson, Sarah; Shumar, Wesley

    2014-01-01

    education into Higher Education discourses can be traced throughout the western world over the last two decades. Whether talking about starting businesses, often the focus for American universities, or encouraging enterprising behavior, the terms used in the UK and some parts of Europe, entrepreneurship...... education has, using models from cognitive psychology and social cognition theories from education gradually become established as a discipline in Higher Education. As educational anthropologists we are interested in exploring the parameters of this new discipline. We propose that the nature...... of this discipline lends itself to ethnography as a method for discussions about how enterprising behaviour is nurtured, supported and evolves into entrepreneurial practices through socially constructed communities. A close look at the practices of entrepreneurship educators in a Danish Higher Education institute...

  14. Quality Assurance in Chinese Higher Education

    Science.gov (United States)

    Li, Yuan

    2010-01-01

    Quality assurance has been integrated into the fabric of higher education in China, with the issue of quality in higher education--how to evaluate it and how to enhance it--now taking centre stage in Chinese higher education. In the past decade, the development of quality assurance in Chinese higher education has covered a broad spectrum of…

  15. Hungary Higher Education Quality Assurance System

    Directory of Open Access Journals (Sweden)

    Che Ru-shan

    2013-07-01

    Full Text Available Higher education quality assurance system has drawn much attention since 1980s. Most countries are committed to build the higher education quality assurance system to meet international standards. Under such an international trend, Hungary also actively promotes higher education reform, and established Hungarian Accreditation Committee and in order to ensure the quality of higher education.

  16. Higher Education and Inequality

    Science.gov (United States)

    Brown, Roger

    2018-01-01

    After climate change, rising economic inequality is the greatest challenge facing the advanced Western societies. Higher education has traditionally been seen as a means to greater equality through its role in promoting social mobility. But with increased marketisation higher education now not only reflects the forces making for greater inequality…

  17. Gender and Higher Education

    Science.gov (United States)

    Bank, Barbara J., Ed.

    2011-01-01

    This comprehensive, encyclopedic review explores gender and its impact on American higher education across historical and cultural contexts. Challenging recent claims that gender inequities in U.S. higher education no longer exist, the contributors--leading experts in the field--reveal the many ways in which gender is embedded in the educational…

  18. Happiness in Higher Education

    Science.gov (United States)

    Elwick, Alex; Cannizzaro, Sara

    2017-01-01

    This paper investigates the higher education literature surrounding happiness and related notions: satisfaction, despair, flourishing and well-being. It finds that there is a real dearth of literature relating to profound happiness in higher education: much of the literature using the terms happiness and satisfaction interchangeably as if one were…

  19. The second higher education and additional education as factors of development of commercialization in Ukrainian higher education

    Directory of Open Access Journals (Sweden)

    M. V. Strigul

    2017-07-01

    Full Text Available The attention in the article has been drawn to the nature and characteristics of commercialization in the higher education system of Ukraine. It has been noted that commercialization in the consumer society is a social process of transformation of knowledge into a product or service. It provides the growing influence of market relations on the goals and objectives of higher education, promotes the growing importance of knowledge as a source for economic development and focuses on the concept of rooting and academic capitalism and the creation of market-oriented and entrepreneurial universities, which provide dynamic development of economy based on knowledge. Defining the essence of the Ukrainian forms of commercialization, there is a significant role of further and second higher education (that is, the presence of a variety of educational forms, which allows the University receiving the profit in the monetary form. The model of commercialization, which is implemented in Ukrainian higher education, differs from the American and Western European ones, as it is focused on financial returns, not on the economization of intellectual profit. Secondly, a peculiar type of consumer behavior, consumerism, which provides growth of profitability of higher education institutions by a variety of additional services (training, additional courses, further education, developing classes, retaking tests, etc.. The factors of development and dynamics of the Ukrainian forms of commercialization, as well as recommendations for avoiding the negative consequences of the economization and commercialization in higher education structure of modern Ukraine have been considered in the article. It has been noted that the University lost its original purpose and became a huge supermarket, which offers various kinds of knowledge. Rational action considers in the desire to buy the most qualitative product – a diploma from a prestigious University. Nowadays, the higher

  20. Reimagining Christian Higher Education

    Science.gov (United States)

    Hulme, E. Eileen; Groom, David E., Jr.; Heltzel, Joseph M.

    2016-01-01

    The challenges facing higher education continue to mount. The shifting of the U.S. ethnic and racial demographics, the proliferation of advanced digital technologies and data, and the move from traditional degrees to continuous learning platforms have created an unstable environment to which Christian higher education must adapt in order to remain…

  1. Relationship between calcium entry and ACh release in K+ -stimulated rat brain synaptosomes

    International Nuclear Information System (INIS)

    Suszkiw, J.B.; O'Leary, M.E.; Toth, G.P.

    1986-01-01

    This paper examines the pattern of Ca ++ entry-dependent ACh release in relation to the kinetics of Ca ++ entry, and its inactivation in rat brain synaptosomes exposed to 50 mM K 0 + for short and prolonged durations. Intrasynaptosomal ACh was radiolabeled from tritium-choline in the presence of 20 um Paraoxon to inhibit the acetylcholinesterase activity. The release of tritium-ACh was studied in superfused synaptosomal beds formed on glass microfiber filters and by rapid filtration. The intermittent stimulation of superfused synaptosomal beds by 3-min pulses of 50 mM K + evoked decremental output of tritium-ACh which reached nearly undetectable levels after the fifth stimulus

  2. Quality of Higher Education

    DEFF Research Database (Denmark)

    Zou, Yihuan; Zhao, Yingsheng; Du, Xiangyun

    . This transformation involves a broad scale of change at individual level, organizational level, and societal level. In this change process in higher education, staff development remains one of the key elements for university innovation and at the same time demands a systematic and holistic approach.......This paper starts with a critical approach to reflect on the current practice of quality assessment and assurance in higher education. This is followed by a proposal that in response to the global challenges for improving the quality of higher education, universities should take active actions...... of change by improving the quality of teaching and learning. From a constructivist perspective of understanding education and learning, this paper also discusses why and how universities should give more weight to learning and change the traditional role of teaching to an innovative approach of facilitation...

  3. Diversity Leadership in Higher Education. ASHE Higher Education Report, Volume 32, Number 3

    Science.gov (United States)

    Aguirre, Adalberto, Jr., Ed.; Martinez, Ruben O., Ed.

    2006-01-01

    This monograph examines and discusses the context for diversity leadership roles and practices in higher education by using research and theoretical and applied literatures from a variety of fields, including the social sciences, business, and higher education. Framing the discussion on leadership in this monograph is the perspective that American…

  4. Fact Book on Higher Education

    Science.gov (United States)

    Marks, Joseph L.; Diaz, Alicia A.

    2009-01-01

    The "Southern Regional Education Board (SREB) Fact Book on Higher Education" is one of the nation's most comprehensive collections of comparative data on higher education. For decades, state leaders, policy-makers, researchers and journalists have used the "Fact Book" to find useful data quickly--and to learn more about…

  5. Higher Education Journals as Didactic Frameworks

    Science.gov (United States)

    Keiding, Tina Bering; Qvortrup, Ane

    2018-01-01

    During the last 20 years, we have witnessed a growing interest in research in teaching, learning and educational development in higher education (HE). The result is that "Higher Education Didactics" has established itself as a research field in its own right. This article explores Higher Education Didactics as a framework for academics'…

  6. 31 CFR 363.38 - What happens if my financial institution returns an ACH debit?

    Science.gov (United States)

    2010-07-01

    ... TreasuryDirect § 363.38 What happens if my financial institution returns an ACH debit? If your designated financial institution returns an ACH debit, we reserve the right to reinitiate the debit at our option. We.... We are not responsible for any fees your financial institution may charge relating to returned ACH...

  7. Co-Creation in Higher Education

    DEFF Research Database (Denmark)

    The main purpose of this book is to disseminate new research on co-creative approaches to teaching and learning in Higher Education (HE). The cases presented draw from a Danish cultural and educational context and have a special focus on collaborative, co-creative and distributed perspectives......-led learning, arts-based approaches to higher educational research and teaching, collaborative practices. We believe that these perspectives are still in need of further investigation through theories and practices. We understand co-creation as the process of creative, original and valuable generation...... of shared meaning and development. This collected volume offers novel empirical documentation and original theoretical reflections on the application of co-creative processes in higher education. This can be directly relevant for educators and the ways in which they design education, but also for students...

  8. Optimization of educational paths for higher education

    Science.gov (United States)

    Tarasyev, Alexandr A.; Agarkov, Gavriil; Medvedev, Aleksandr

    2017-11-01

    In our research, we combine the theory of economic behavior and the methodology of increasing efficiency of the human capital to estimate the optimal educational paths. We provide an optimization model for higher education process to analyze possible educational paths for each rational individual. The preferences of each rational individual are compared to the best economically possible educational path. The main factor of the individual choice, which is formed by the formation of optimal educational path, deals with higher salaries level in the chosen economic sector after graduation. Another factor that influences on the economic profit is the reduction of educational costs or the possibility of the budget support for the student. The main outcome of this research consists in correction of the governmental policy of investment in human capital based on the results of educational paths optimal control.

  9. Open Educational Practices in Higher Education: Institutional Adoption and Challenges

    Science.gov (United States)

    Murphy, Angela

    2013-01-01

    Open educational resources and open education practices have the potential to lower costs and increase participation in higher education. One hundred and ten individuals from higher education institutions around the world participated in a survey aimed at identifying the extent to which higher education institutions are currently implementing open…

  10. Exploring Higher Education Financing Options

    Science.gov (United States)

    Nkrumah-Young, Kofi K.; Powell, Philip

    2011-01-01

    Higher education can be financed privately, financed by governments, or shared. Given that the benefits of education accrue to the individual and the state, many governments opt for shared financing. This article examines the underpinnings of different options for financing higher education and develops a model to compare conditions to choices and…

  11. Ultramicromorphological observation of Usnea longissima Ach ...

    African Journals Online (AJOL)

    The Usnea longissima Ach. grew as an epiphyte on Abies georgei and was collected at an altitude of 3640 m above sea level from the Pudacuo National Park in the Shangri-La County of the Diqing Tibetan Autonomous Prefecture in the Yunnan Province of China. Scanning electron microscopy revealed the ...

  12. Tuning of the microstructure, mechanical and tribological properties of a-C:H films by bias voltage of high frequency unipolar pulse

    International Nuclear Information System (INIS)

    Wang, Jia; Cao, Zhongyue; Pan, Fuping; Wang, Fuguo; Liang, Aimin; Zhang, Junyan

    2015-01-01

    Highlights: • a-C:H films deposited by high frequency unipolar pulse PECVD. • The film structures can be adjusted by bias voltage. • More graphitic structures form at high bias voltage. • The mechanical and tribological properties are improved by these structures. - Abstract: Amorphous hydrogenated carbon (a-C:H) films were prepared by high frequency unipolar pulse plasma-enhanced chemical vapor deposition in CH 4 , Ar, and H 2 atmosphere with the bias voltage in the range of −800 –−1600 V. The microstructures and mechanical properties of a-C:H films were investigated via high resolution transmission electron microscope (HRTEM), Raman spectroscopy, and Nanoindenter. The results reveal that the curved and straight graphitic microstructures appear in amorphous carbon matrix, and their contents increase obviously with the bias voltage. At the same time, the corresponding hardness decreases and elastic recovery increases, however even in such a case films still possess excellent mechanical properties. According to the tribological property characterization, we believe that the bias voltage also influences their tribological performances significantly, the higher the bias voltage finally gets, the lower the friction coefficient and wear rate occur. These results indicate that the microstructures of a-C:H films can be tuned efficiently by bias voltage and the films with good mechanical and tribological properties can be obtained at a higher range.

  13. Tuning of the microstructure, mechanical and tribological properties of a-C:H films by bias voltage of high frequency unipolar pulse

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jia; Cao, Zhongyue; Pan, Fuping [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Wang, Fuguo, E-mail: fgwang@licp.cas.cn [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Liang, Aimin [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhang, Junyan, E-mail: zhangjunyan@licp.cas.cn [State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2015-11-30

    Highlights: • a-C:H films deposited by high frequency unipolar pulse PECVD. • The film structures can be adjusted by bias voltage. • More graphitic structures form at high bias voltage. • The mechanical and tribological properties are improved by these structures. - Abstract: Amorphous hydrogenated carbon (a-C:H) films were prepared by high frequency unipolar pulse plasma-enhanced chemical vapor deposition in CH{sub 4}, Ar, and H{sub 2} atmosphere with the bias voltage in the range of −800 –−1600 V. The microstructures and mechanical properties of a-C:H films were investigated via high resolution transmission electron microscope (HRTEM), Raman spectroscopy, and Nanoindenter. The results reveal that the curved and straight graphitic microstructures appear in amorphous carbon matrix, and their contents increase obviously with the bias voltage. At the same time, the corresponding hardness decreases and elastic recovery increases, however even in such a case films still possess excellent mechanical properties. According to the tribological property characterization, we believe that the bias voltage also influences their tribological performances significantly, the higher the bias voltage finally gets, the lower the friction coefficient and wear rate occur. These results indicate that the microstructures of a-C:H films can be tuned efficiently by bias voltage and the films with good mechanical and tribological properties can be obtained at a higher range.

  14. Changing Boundaries in Israeli Higher Education.

    Science.gov (United States)

    Guri-Rosenblit, Sarah

    1999-01-01

    Analyzes changes that have occurred in Israeli's higher education system over the decades, accounting for the reconstruction of its external and internal boundaries. Provides a conceptual framework for comparing national higher education systems. Examines developments characterizing the restructuring of Israeli higher education from a…

  15. Aging of oxygen and hydrogen plasma discharge treated a-C:H and ta-C coatings

    Science.gov (United States)

    Bachmann, Svenja; Schulze, Marcus; Morasch, Jan; Hesse, Sabine; Hussein, Laith; Krell, Lisa; Schnagl, Johann; Stark, Robert W.; Narayan, Suman

    2016-05-01

    Surface modification with gas plasma is an efficient and easy way to improve the surface energy and the tribological behavior of diamond-like carbon (DLC) coatings, e.g., in biomedical implants or as protective coatings. However, the long-term performance of the plasma treated DLC coatings is not fully clear. We thus studied the long-term stability of two kinds of DLC coatings, namely (a) hydrogenated amorphous carbon (a-C:H) and (b) tetrahedral amorphous carbon (ta-C) treated at different radio frequency (RF) power and time of oxygen (O2) and hydrogen (H2) plasma. Their surface properties, e.g. surface wettability, structure and tribological behavior, were studied at regular intervals for a period of two months using contact angle goniometer, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), lateral force microscopy (LFM) and ball on disc apparatus. The surface energy of both the coatings decreased upon aging. The higher the RF power and time of treatment, the higher was the hydrophobicity upon aging. XPS analysis showed that the increase in hydrophobicity could be due to adsorption of unavoidable volatile organic components in the atmosphere. The H2 plasma treated ta-C was capable of rearranging its structural bonds upon aging. The nano-friction measurements by LFM showed that the coefficient of friction of plasma treated a-C:H and ta-C decreased upon aging. The results indicate that the surface properties of plasma treated a-C:H and ta-C are not stable on long-term and are influenced by the environmental conditions.

  16. Education for Sustainable Development in Higher Education Institutions

    Directory of Open Access Journals (Sweden)

    César Tapia-Fonllem

    2017-01-01

    Full Text Available The role that higher education plays in the promotion of sustainable development outstands in the declarations on Education for Sustainable Development (ESD, besides being a research priority in higher education. However, few studies exist that evaluate sustainable lifestyles among university students. The aim of this study was to analyze the mission and vision, processes and actions undertaken to promote sustainability in higher education institutions, and to compare the pro-sustainability orientation (PSO reported by 360 students coursing first or last semesters at college. The study was intended to evaluate the influence that four higher education institutions in Sonora, Mexico, have on students’ PSO. Results of the study indicate that a coherent PSO factor emerges from the interrelations among pro-environmental dispositional and behavioral variables reported by students. However, university programs and actions do not produce statistically significant differences between freshmen and senior students. Possible reasons explaining the lack of positive influence of those universities on students’ PSO are discussed.

  17. Student Volunteering in English Higher Education

    Science.gov (United States)

    Holdsworth, Clare; Quinn, Jocey

    2010-01-01

    Volunteering in English higher education has come under political scrutiny recently, with strong cross-party support for schemes to promote undergraduate volunteering in particular. Recent targeted initiatives and proposals have sought to strengthen both the role of volunteering in higher education and synergies between higher education and…

  18. Measuring Institutional Performance in Higher Education.

    Science.gov (United States)

    Meyerson, Joel W., Ed.; Massy, William F., Ed.

    This collection of seven essays from the Stanford Forum for Higher Education Futures focuses on how downsizing, quality management, and reengineering have are affecting higher education. An introductory paper, "Introduction: Change in Higher Education: Its Effect on Institutional Performance," (Joel W. Meyerson and Sandra L. Johnson)…

  19. Pharmacological and immunochemical characterization of α2* nicotinic acetylcholine receptors (nAChRs) in mouse brain

    Science.gov (United States)

    Whiteaker, Paul; Wilking, Jennifer A; Brown, Robert WB; Brennan, Robert J; Collins, Allan C; Lindstrom, Jon M; Boulter, Jim

    2009-01-01

    Aim: α2 nAChR subunit mRNA expression in mice is most intense in the olfactory bulbs and interpeduncular nucleus. We aimed to investigate the properties of α2* nAChRs in these mouse brain regions. Methods: α2 nAChR subunit-null mutant mice were engineered. Pharmacological and immunoprecipitation studies were used to determine the composition of α2 subunit-containing (α2*) nAChRs in these two regions. Results: [125I]Epibatidine (200 pmol/L) autoradiography and saturation binding demonstrated that α2 deletion reduces nAChR expression in both olfactory bulbs and interpeduncular nucleus (by 4.8±1.7 and 92±26 fmol̇mg-1 protein, respectively). Pharmacological characterization using the β2-selective drug A85380 to inhibit [125I]epibatidine binding proved inconclusive, so immunoprecipitation methods were used to further characterize α2* nAChRs. Protocols were established to immunoprecipitate β2 and β4 nAChRs. Immunoprecipitation specificity was ascertained using tissue from β2- and β4-null mutant mice, and efficacy was good (>90% of β2* and >80% of β4* nAChRs were routinely recovered). Conclusion: Immunoprecipitation experiments indicated that interpeduncular nucleus α2* nAChRs predominantly contain β2 subunits, while those in olfactory bulbs contain mainly β4 subunits. In addition, the immunoprecipitation evidence indicated that both nuclei, but especially the interpeduncular nucleus, express nAChR complexes containing both β2 and β4 subunits. PMID:19498420

  20. Teaching Creatively in Higher Education

    DEFF Research Database (Denmark)

    Chemi, Tatiana; Zhou, Chunfang

    The topic of this booklet is a synthesis of relevant research in the field of creativity in higher education, with focus on creative teaching methods. By means of literature review and research findings this booklet describes a wide range of contexts and effects on student learning and develop­me......­ment, together with teacher motivation and overall satisfaction. This booklet meets the need for renewal and creation in higher education, in order to address the challenges of the future, focusing on the benefits of teaching crea­tively at higher education.......The topic of this booklet is a synthesis of relevant research in the field of creativity in higher education, with focus on creative teaching methods. By means of literature review and research findings this booklet describes a wide range of contexts and effects on student learning and develop...

  1. Biochemical effects of glyphosate based herbicide, Excel Mera 71 on enzyme activities of acetylcholinesterase (AChE), lipid peroxidation (LPO), catalase (CAT), glutathione-S-transferase (GST) and protein content on teleostean fishes.

    Science.gov (United States)

    Samanta, Palas; Pal, Sandipan; Mukherjee, Aloke Kumar; Ghosh, Apurba Ratan

    2014-09-01

    Effects of glyphosate based herbicide, Excel Mera 71 at a dose of 17.20mg/l on enzyme activities of acetylcholinesterase (AChE), lipid peroxidation (LPO), catalase (CAT), glutathione-S-transferase (GST) and protein content were measured in different tissues of two Indian air-breathing teleosts, Anabas testudineus (Bloch) and Heteropneustes fossilis (Bloch) during an exposure period of 30 days under laboratory condition. AChE activity was significantly increased in all the investigated tissues of both fish species and maximum elevation was observed in brain of H. fossilis, while spinal cord of A. testudineus showed minimum increment. Fishes showed significant increase LPO levels in all the tissues; highest was observed in gill of A. testudineus but lowest LPO level was observed in muscle of H. fossilis. CAT was also enhanced in both the fishes, while GST activity in liver diminished substantially and minimum was observed in liver of A. testudineus. Total protein content showed decreased value in all the tissues, maximum reduction was observed in liver and minimum in brain of A. testudineus and H. fossilis respectively. The results indicated that Excel Mera 71 caused serious alterations in the enzyme activities resulting into severe deterioration of fish health; so, AChE, LPO, CAT and GST can be used as suitable indicators of herbicidal toxicity. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus.

    Directory of Open Access Journals (Sweden)

    Daniel A Nagode

    Full Text Available Acetylcholine (ACh influences a vast array of phenomena in cortical systems. It alters many ionic conductances and neuronal firing behavior, often by regulating membrane potential oscillations in populations of cells. Synaptic inhibition has crucial roles in many forms of oscillation, and cholinergic mechanisms regulate both oscillations and synaptic inhibition. In vitro investigations using bath-application of cholinergic receptor agonists, or bulk tissue electrical stimulation to release endogenous ACh, have led to insights into cholinergic function, but questions remain because of the relative lack of selectivity of these forms of stimulation. To investigate the effects of selective release of ACh on interneurons and oscillations, we used an optogenetic approach in which the light-sensitive non-selective cation channel, Channelrhodopsin2 (ChR2, was virally delivered to cholinergic projection neurons in the medial septum/diagonal band of Broca (MS/DBB of adult mice expressing Cre-recombinase under the control of the choline-acetyltransferase (ChAT promoter. Acute hippocampal slices obtained from these animals weeks later revealed ChR2 expression in cholinergic axons. Brief trains of blue light pulses delivered to untreated slices initiated bursts of ACh-evoked, inhibitory post-synaptic currents (L-IPSCs in CA1 pyramidal cells that lasted for 10's of seconds after the light stimulation ceased. L-IPSC occurred more reliably in slices treated with eserine and a very low concentration of 4-AP, which were therefore used in most experiments. The rhythmic, L-IPSCs were driven primarily by muscarinic ACh receptors (mAChRs, and could be suppressed by endocannabinoid release from pyramidal cells. Finally, low-frequency oscillations (LFOs of local field potentials (LFPs were significantly cross-correlated with the L-IPSCs, and reversal of the LFPs near s. pyramidale confirmed that the LFPs were driven by perisomatic inhibition. This optogenetic approach

  3. Higher Education Leadership Graduate Program Development

    Science.gov (United States)

    Freeman, Sydney, Jr.; Chambers, Crystal Renée; Newton, Rochelle

    2016-01-01

    Graduate programs in higher education administration and leadership have sought to equip students with the knowledge, skills, and competencies for higher education leadership; that is, to prepare globally minded leaders who can navigate the internal and external demands of, and for, higher education. With the use of the Lattuca and Stark model of…

  4. Evaluating Public Higher Education in Mexico

    Science.gov (United States)

    Varela-Petito, Gonzalo

    2011-01-01

    In an effort to ensure accountability, and in order to prepare students for a globalised world, the higher education sector in Mexico is seeking to implement an evaluation of public higher education. Higher education institutions (HEIs) need to balance this goal against the need to protect their autonomy. This would be preserved if each…

  5. Redefining External Stakeholders in Nordic Higher Education

    Science.gov (United States)

    Musial, Kazimierz

    2010-01-01

    Present higher education reforms in the Nordic countries diminish the role and influence of the state on the governance of higher education institutions. While still providing a framework for the management of higher education, in general, the state supervises rather than controls higher education institutions (HEIs). The rhetoric of change…

  6. Higher education journals as didactic frameworks

    DEFF Research Database (Denmark)

    Keiding, Tina Bering; Qvortrup, Ane

    2018-01-01

    topics. Students as participants and learners are a frequent topic in especially one journal, but receive little attention in the other journals. Also, educational technologies receive a varying degree of attention across the journals. Based on the mapping, this article discusses Higher Education......During the last 20 years, we have witnessed a growing interest in research in teaching, learning and educational development in higher education (HE). The result is that ‘Higher Education Didactics’ has established itself as a research field in its own right. This article explores Higher Education...... influential, while the others stem from the Anglo-Saxon curriculum tradition. The mapping shows that all journals are strongly occupied with teaching methods, especially methods grounded in theories of active and social learning. In contrast, didactic categories such as goal, content and assessment are rare...

  7. Investment Management in Higher Education Institutions

    Directory of Open Access Journals (Sweden)

    Jelena Stankevičienė

    2015-05-01

    Full Text Available Recently, the higher education sector faces a series of changes, such as increased competition, globalization, limited funding. Limited funding does not reveal the full potential of the higher education, too little funding restricts research performance, diminishes the quality of higher education, worsen the conditions for learning and this has important implications for sustainable value creation. The article explores relationship between education, sustainability and financial indicators in order to evaluate the situation and advancement in the European countries, applied multi-criteria evaluation method MULTIMOORA. This method aims to prove that the more encourage investment in higher education and research, the more sustainable the state is and creates sustainable value. The results revealed that the more financially stronger and stable country is, the better position by assessing both the scientific and the sustainability indicators. Financially stable country can give higher investment in education, to promote the conduct of research, create conditions for the formation of high-quality R&D, to prepare highly qualified specialists.

  8. Higher Education.

    Science.gov (United States)

    Hendrickson, Robert M.

    This chapter reports 1982 cases involving aspects of higher education. Interesting cases noted dealt with the federal government's authority to regulate state employees' retirement and raised the questions of whether Title IX covers employment, whether financial aid makes a college a program under Title IX, and whether sex segregated mortality…

  9. Regulation of ACh release from guinea pig bladder urothelial cells: potential role in bladder filling sensations.

    Science.gov (United States)

    McLatchie, L M; Young, J S; Fry, C H

    2014-07-01

    The aim of this study was to quantify and characterize the mechanism of non-neuronal ACh release from bladder urothelial cells and to determine if urothelial cells could be a site of action of anti-muscarinic drugs. A novel technique was developed whereby ACh could be measured from freshly isolated guinea pig urothelial cells in suspension following mechanical stimulation. Various agents were used to manipulate possible ACh release pathways in turn and to study the effects of muscarinic receptor activation and inhibition on urothelial ATP release. Minimal mechanical stimulus achieved full ACh release, indicating a small dynamic range and possible all-or-none signal. ACh release involved a mechanism dependent on the anion channel CFTR and intracellular calcium concentration, but was independent of extracellular calcium, vesicular trafficking, connexins or pannexins, organic cation transporters and was not affected by botulinum-A toxin. Stimulating ACh receptors increased ATP production and antagonizing them reduced ATP release, suggesting a link between ACh and ATP release. These results suggest that release of non-neuronal ACh from the urothelium is large enough and well located to act as a modulator of ATP release. It is hypothesized that this pathway may contribute to the actions of anti-muscarinic drugs in reducing the symptoms of lower urinary tract syndromes. Additionally the involvement of CFTR in ACh release suggests an exciting new direction for the treatment of these conditions. © 2014 The British Pharmacological Society.

  10. Disruptive Technologies in Higher Education

    Science.gov (United States)

    Flavin, Michael

    2012-01-01

    This paper analyses the role of "disruptive" innovative technologies in higher education. In this country and elsewhere, Higher Education Institutions (HEIs) have invested significant sums in learning technologies, with Virtual Learning Environments (VLEs) being more or less universal, but these technologies have not been universally…

  11. Chinese Students' Choice of Transnational Higher Education in a Globalized Higher Education Market: A Case Study of W University

    Science.gov (United States)

    Fang, Wenhong; Wang, Shen

    2014-01-01

    This research studies Chinese students' choice of transnational higher education in the context of the higher education market. Through a case study of the students in the transnational higher education programs of W University, the research finds that Chinese students' choice of transnational higher education is a complicated decision-making that…

  12. COMMUNITARIAN INSTITUTIONS FOR HIGHER EDUCATION: CURRENT ISSUES

    Directory of Open Access Journals (Sweden)

    Helio Radke Bittencourt

    2014-11-01

    Full Text Available Since 2010, the Brazilian communitarian institutions for higher education are not included officially under this designation in the INEP’s microdata, with the extinction of the category “communitarian, religious and philanthropic”. Since then, the Brazilian private’s higher education institutions are classified according to their legal nature: for-profit or non-profit. Nevertheless, the new law 12.881 of 2013, enacted in November 2013, has changed this reality after the approval by the National Congress, establishing the definition and purpose of the Community institutions, and confirming, in particular, their characteristics of non-profit institutions belonging to civil society, and their organization into associations or foundations (BRAZIL, 2013. The recent expansion of the federal and for-profit higher education institutions has directly affected the so far called communitarian institutions, which present differentiated characteristics compared to forprofit private higher education institutions as well as public education. In this article, data and contemporary aspects related to the new scenario of Brazilian higher education are analyzed, with special focus on higher education institutions members of the Association of Community Universities (ABRUC, and were found better performance of these ones in comparison to the private for-profit higher education institutions. The obtained results, combined with the regional impact of the communitarian higher education institutions, justify the importance of these institutions to improve the consolidation of higher education in Brazil.

  13. California's Future: Higher Education

    Science.gov (United States)

    Johnson, Hans

    2015-01-01

    California's higher education system is not keeping up with the changing economy. Projections suggest that the state's economy will continue to need more highly educated workers. In 2025, if current trends persist, 41 percent of jobs will require at least a bachelor's degree and 36 percent will require some college education short of a bachelor's…

  14. Strategic Planning for Higher Education.

    Science.gov (United States)

    Kotler, Philip; Murphy, Patrick E.

    1981-01-01

    The framework necessary for achieving a strategic planning posture in higher education is outlined. The most important benefit of strategic planning for higher education decision makers is that it forces them to undertake a more market-oriented and systematic approach to long- range planning. (Author/MLW)

  15. Learning Entrepreneurship in Higher Education

    Science.gov (United States)

    Taatila, Vesa P.

    2010-01-01

    Purpose: There is a constant need to produce more entrepreneurial graduates from higher education institutions. This paper aims to present and discuss several successful cases of entrepreneurial learning environments in order to suggest some important aspects that higher education institutions should consider. Design/methodology/approach: The…

  16. Feminist Research in Higher Education

    Science.gov (United States)

    Ropers-Huilman, Rebecca; Winters, Kelly T.

    2011-01-01

    This essay provides an overview of feminist methodology and its potential to enhance the study of higher education. Foregrounding the multiple purposes and research relationships developed through feminist research, the essay urges higher education scholars to engage feminist theories, epistemologies, and methods to inform policy, research, and…

  17. The Faceless Masters of Higher Education

    DEFF Research Database (Denmark)

    Jensen, Katja Brøgger

    2015-01-01

    This dissertation contributes to research on international higher education reform by offering an empirical and theoretical account of the mode of governance that characterizes the Bologna Process and by demonstrating how the reform materializes and is translated in everyday working life, including......, and c) professors and managers’ translations of the Bologna Process, including the ways in which the reform processes alter professional working life in higher education organizations. The research project employs a combination of qualitative methods and materials, including interviews, observations...... of higher education despite the fact that education falls outside EU’s legislative reach. The dissertation further argues that the spread and continuous development and production of higher education standards in Europe depends on the infrastructure of the Bologna Process, which consists of an explosion...

  18. Public higher education in the Philippines

    Science.gov (United States)

    Cardozier, V. R.

    1984-06-01

    Clearly, the national government of the Philippines has decided to increase the number and comprehensiveness of its public colleges and universities. While private colleges and universities are likely to dominate higher education in the Philippines for the remainer of this century, it appears that public, tax-supported higher education will become increasingly available there. The Philippines is not a wealthy country but it is devoting a substantial portion of its national resources to public higher education. In 1983, higher education received 2.85 percent of the national budget, a figure that has been rising for years. Compared with some highly developed countries, this is not a large percentage, but for a country that has traditionally relied on private higher education, it is a major and growing investment in the public sector. While many of the better universities in the Philippines are private, many other private educational institutions are small and struggling. As their financial resources become more limited, and as less expensive, tax-supported higher education becomes increasingly available, a lot of the struggling private colleges will probably close. This process is also being hastened by actions of the government to upgrade quality, for example in the case of the many private colleges that developed after World War II. In an attempt to improve the academic quality of these marginal institutions, the Ministry of Education, Culture and Sports has been given extensive authority, and while its intrusion into private institutions has been modest by some measures, its requirements are affecting them all and will speed the demise of some. This is bound to lead to a stronger role for public higher education in the Philippines, a country that is striving diligently to improve the education and hence the quality of life of its people.

  19. Examining Multimedia Competencies for Educational Technologists in Higher Education

    Science.gov (United States)

    Iqdami, Muhammad Nazil; Branch, Robert Maribe

    2016-01-01

    The authors investigated educational technology multimedia competencies for professionals who work in higher education institutions. Similar studies have been proposed, but none of them have focused on competencies required in the context of higher education. An online survey adapting sixteen competency factors from a study conducted by Rizhaupt…

  20. Women in Higher Education Administration.

    Science.gov (United States)

    Association of American Colleges, Washington, DC. Project on the Status and Education of Women.

    Two papers are presented that examine the barriers to women in academic decision making and identify a variety of effective strategies for improving the status of women in higher education administration. "Strategies for Advancing Women in Higher Education Administration," by Garry D. Hays, proposes that commitment to increasing the…

  1. Innovations in Higher Education? Hah!

    Science.gov (United States)

    Kirschner, Ann

    2012-01-01

    One can hardly mention higher education today without hearing the word "innovation," or its understudies "change," "reinvention," "transformation." Last summer the National Governors Association opened its meeting with a plenary session on higher education, innovation, and economic growth. But there is nothing funny about the need for innovation…

  2. Sustainable spatial development in higher education

    Directory of Open Access Journals (Sweden)

    Maja Terlević

    2015-06-01

    Full Text Available Sustainable development is not only a great challenge for society as a whole, but also for higher education institutions, which have been rapidly including sustainable development in their educational process in the last two decades. Directly or indirectly, education for sustainable spatial development includes all aspects of sustainable development: environmental, economic, social and cultural. Space is a junction of various interests, which requires coordinating the entire process of spatial planning, taking into account the goal of sustainable spatial development. The existing values of space are insufficient for the rapid implementation of a sustainable spatial development paradigm. Suitable education is needed by both individuals and spatial planning professionals and at all levels of education. It is therefore necessary to transform some of the academic programs in the higher education curriculum by integrating teaching content and methods that include long-term knowledge and holistic thinking, taking into account the importance of interdisciplinary integration. This article reviews literature in sustainable development in higher education from 2002 to 2013. Topics discussed include students’ and teachers’ conceptions of sustainable development, the presence of sustainable development and sustainable spatial development in higher education and the reasons for the slow introduction of this material into the curriculum. Based on a literature analysis, the last section identifies important drivers that can contribute to a more rapid integration of a sustainable spatial development paradigm into higher education.

  3. CONSIDERATIONS REGARDING ROMANIAN HIGHER EDUCATION GRADUATES

    Directory of Open Access Journals (Sweden)

    Popovici (Barbulescu Adina

    2012-07-01

    Full Text Available The paper aims at analyzing the dynamics of in Romanian higher education graduates in the 2006-2010 period, both in Romania and by the Romanian development regions. After highlighting the importance of human capital and its education, the paper analyzes the dynamics of Romanian higher education graduates in the targeted period, at both of the above-mentioned levels. The conclusions reveal that, during the analysed period: 2006-2010, the number of female, and, respectively, male higher education graduates, as well as the total number of higher education graduates, continuously increased in the 2006-2010 period at the whole country level and registered an increase trend, as well, by the eight development regions of Romania in the 2006-2010 period, with very few exceptions in some years of the period, in some of the the eight development regions of Romania. Therefore, the Romanian higher education system must correlate the graduates number with the number of work places in the Romanian economy, and take into account the necessities imposed by the participation at international competition.

  4. Higher Education, Employability and Competitiveness

    Science.gov (United States)

    Pavlin, Samo; Svetlicic, Marjan

    2012-01-01

    This paper studies the relationship between competitiveness and higher education systems in Europe. It explores whether more competitive countries have developed more labour-market-oriented systems of higher education (HE) that thereby give their graduates greater short term employability potential. Based on and a large-scale survey among 45.000…

  5. Polish Higher Education: Intersectoral Distinctiveness

    Science.gov (United States)

    Musial, Joanna

    2014-01-01

    This study analyzes degrees of differences between the private and public sectors of Polish higher education. It finds them to be strong: Polish private institutions function very differently from Polish public institutions and these differences correspond with those found in the literature on higher education elsewhere in the world. Polish…

  6. Valid Competency Assessment in Higher Education

    Directory of Open Access Journals (Sweden)

    Olga Zlatkin-Troitschanskaia

    2017-01-01

    Full Text Available The aim of the 15 collaborative projects conducted during the new funding phase of the German research program Modeling and Measuring Competencies in Higher Education—Validation and Methodological Innovations (KoKoHs is to make a significant contribution to advancing the field of modeling and valid measurement of competencies acquired in higher education. The KoKoHs research teams assess generic competencies and domain-specific competencies in teacher education, social and economic sciences, and medicine based on findings from and using competency models and assessment instruments developed during the first KoKoHs funding phase. Further, they enhance, validate, and test measurement approaches for use in higher education in Germany. Results and findings are transferred at various levels to national and international research, higher education practice, and education policy.

  7. INTERNATIONALIZATION IN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Catalina Crisan-Mitra

    2016-03-01

    Full Text Available Internationalization of higher education is one of the key trends of development. There are several approaches on how to achieve competitiveness and performance in higher education and international academic mobility; students’ exchange programs, partnerships are some of the aspects that can play a significant role in this process. This paper wants to point out the student’s perception regarding two main directions: one about the master students’ expectation regarding how an internationalized master should be organized and should function, and second the degree of satisfaction of the beneficiaries of internationalized master programs from Babe-Bolyai University. This article is based on an empirical qualitative research that was implemented to students of an internationalized master from the Faculty of Economics and Business Administration. This research can be considered a useful example for those preoccupied to increase the quality of higher education and conclusions drawn have relevance both theoretically and especially practically.

  8. Analysis of education conditions in higher educational institutions of Ukraine

    Directory of Open Access Journals (Sweden)

    Олександр Петрович Бурмістенков

    2016-12-01

    Full Text Available The article deals with some issues related to higher technical education conditions in Ukraine, namely, training and certification of graduates of schools, training of students in higher educational institutions and motivation of students to study and teachers to improve teaching methods and deep research within the walls of institution. The causes of education level reduction are expressed. The propositions are made for improving the higher education quality

  9. Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE?

    Science.gov (United States)

    Fossati, Sara Maria; Candiani, Simona; Nödl, Marie-Therese; Maragliano, Luca; Pennuto, Maria; Domingues, Pedro; Benfenati, Fabio; Pestarino, Mario; Zullo, Letizia

    2015-08-01

    Acetylcholinesterase (ACHE) is a glycoprotein with a key role in terminating synaptic transmission in cholinergic neurons of both vertebrates and invertebrates. ACHE is also involved in the regulation of cell growth and morphogenesis during embryogenesis and regeneration acting through its non-cholinergic sites. The mollusk Octopus vulgaris provides a powerful model for investigating the mechanisms underlying tissue morphogenesis due to its high regenerative power. Here, we performed a comparative investigation of arm morphogenesis during adult arm regeneration and embryonic arm development which may provide insights on the conserved ACHE pathways. In this study, we cloned and characterized O. vulgaris ACHE, finding a single highly conserved ACHE hydrophobic variant, characterized by prototypical catalytic sites and a putative consensus region for a glycosylphosphatidylinositol (GPI)-anchor attachment at the COOH-terminus. We then show that its expression level is correlated to the stage of morphogenesis in both adult and embryonic arm. In particular, ACHE is localized in typical neuronal sites when adult-like arm morphology is established and in differentiating cell locations during the early stages of arm morphogenesis. This possibility is also supported by the presence in the ACHE sequence and model structure of both cholinergic and non-cholinergic sites. This study provides insights into ACHE conserved roles during processes of arm morphogenesis. In addition, our modeling study offers a solid basis for predicting the interaction of the ACHE domains with pharmacological blockers for in vivo investigations. We therefore suggest ACHE as a target for the regulation of tissue morphogenesis.

  10. Manpower Aspects of Higher Education in India.

    Science.gov (United States)

    Khan, Qamar Uddin

    Using data from various published sources, this report reviews the growth of higher education in India over the last 30 years, analyzes employers' needs for higher education graduates since 1950, and suggests guidelines for involving educational planning with manpower planning. The author describes the growth of Indian higher education in the…

  11. Marketing activities of higher education institutions

    Directory of Open Access Journals (Sweden)

    Varađanin Vladimir

    2017-01-01

    Full Text Available Public sector marketing is a modern-day scientific discipline which is getting more and more attention. Institutions of higher education provide a specific kind of services to their users, which makes these institutions a part of the public sector. Due to dynamic changes in the environment, the demands and needs of higher education institution's users change, which makes it necessary to monitor these changes through certain marketing activities and adjust to them in order to satisfy the users' needs. Each higher education institution sets its own goals which, broadly speaking, are to meet their own needs, the needs of students and the society as a whole. Therefore, when formulating a strategy for achieving the objectives of higher education institutions, it is necessary to have timely information from the environment. The modern approach to business puts forward the service users' needs. When it comes to institutions of higher education, the users are primarily students, who thus get the most attention. Keeping this in mind, we have conducted a research among students in order to identify the choice factors influencing their higher education institution selection process. The results obtained should provide guidelines for creating an adequate marketing mix in order to gain competitive advantage on the market for higher education. In the research descriptive and comparative methods were used. In the practical part of the research, survey technique was applied by means of a non-standardized questionnaire. The research results imply that the analysis of the factors influencing the process of selecting the higher education institution enables the creation of an adequate combination of instruments in a marketing mix which can then be used as an instrument for gaining competitive advantage.

  12. Queering Transformation in Higher Education

    Science.gov (United States)

    Msibi, Thabo

    2013-01-01

    Transformation in higher education has tended to focus on race and sex, at the expense of other forms of discrimination. This article addresses the silencing of "queer" issues in higher education. Using queer theory as a framework, and drawing on current literature, popular media reports, two personal critical incidents and a project…

  13. Reforming Iraqi Journalism and Mass Communication Higher Education: Adapting the UNESCO Model Curricula for Journalism Education to Iraqi Higher Education

    Science.gov (United States)

    Pavlik, John V.; Laufer, Peter D.; Burns, David P.; Ataya, Ramzi T.

    2012-01-01

    Journalism and mass communication higher education in Iraq is well established but largely isolated from global developments since the 1970s. In the post-Iraq war period, the United Nations Educational, Scientific and Cultural Organization (UNESCO) implemented a multiyear project to work with the leadership of Iraqi higher education to help update…

  14. Reputation in Higher Education

    DEFF Research Database (Denmark)

    Plewa, Carolin; Ho, Joanne; Conduit, Jodie

    2016-01-01

    Reputation is critical for institutions wishing to attract and retain students in today's competitive higher education setting. Drawing on the resource based view and configuration theory, this research proposes that Higher Education Institutions (HEIs) need to understand not only the impact...... of independent resources but of resource configurations when seeking to achieve a strong, positive reputation. Utilizing fuzzy set qualitative comparative analysis (fsQCA), the paper provides insight into different configurations of resources that HEIs can utilize to build their reputation within their domestic...

  15. Reputation in Higher Education

    DEFF Research Database (Denmark)

    Martensen, Anne; Grønholdt, Lars

    2005-01-01

    leaders of higher education institutions to set strategic directions and support their decisions in an effort to create even better study programmes with a better reputation. Finally, managerial implications and directions for future research are discussed.Keywords: Reputation, image, corporate identity......The purpose of this paper is to develop a reputation model for higher education programmes, provide empirical evidence for the model and illustrate its application by using Copenhagen Business School (CBS) as the recurrent case. The developed model is a cause-and-effect model linking image...

  16. Quantitative Developments in Turkish Higher Education since 1933

    Directory of Open Access Journals (Sweden)

    Aslı GÜNAY

    2011-01-01

    Full Text Available In this study, quantitative developments in Turkish higher education during the Republic period from 1933, when the first university was established, to date are tried to be demonstrated. In parallel with this purpose, first, establishment dates of universities, number of universities by years as well as number of universities established during the periods of each presidents of Turkish Council of Higher Education are listed. Also, spread to all provinces as of 2008, the distribution of the number of universities with regard to provinces is given. On the other hand, development of Turkish higher education by years is examined by using several quantitative indicators about higher education. Thus, number of students in higher education, total number of academic staffs as well as those with PhD, improvement in the number of students per academic staff and higher education gross enrollment rates by years are shown. Furthermore, especially for big provinces in Turkey (Ankara, İstanbul and İzmir number of universities, number of students in higher education and higher education gross enrollment rates are provided. Distribution of higher education students according to higher education institutions, higher education programs and education types in 2011 is presented as well as distribution of academic staffs according to higher education institutions and information about their academic positions. In addition, quantitative data about higher education bachelor and associate degrees (numbers of programs types, programs, quotas and placed students in 2010 is given. Finally, the position of Turkish higher education in the world with respect to the number of academic publications and the change in the number of academic publications per staff by years are analyzed.

  17. Investigating Effective Components of Higher Education Marketing and Providing a Marketing Model for Iranian Private Higher Education Institutions

    Science.gov (United States)

    Kasmaee, Roya Babaee; Nadi, Mohammad Ali; Shahtalebi, Badri

    2016-01-01

    Purpose: The purpose of this paper is to study and identify the effective components of higher education marketing and providing a marketing model for Iranian higher education private sector institutions. Design/methodology/approach: This study is a qualitative research. For identifying the effective components of higher education marketing and…

  18. Higher education in the era of globalisation

    OpenAIRE

    Siddiqui, Kalim

    2014-01-01

    The article will analyse the impact of globalisation on higher education. Some have argued that globalisation will\\ud provide equal opportunities. While others claim that globalisation would mean the McDonaldisation of the university and\\ud also worldwide inequality. The current pressure on higher education mainly due to neoliberal globalisation has increased\\ud the role for private sector in higher education. The paper examines the realities of globalisation in higher education to\\ud highlig...

  19. The System of Higher Education in CSFR

    OpenAIRE

    Kopp, Botho von

    1991-01-01

    By dividing his article in two chapters ("1. From the founding of Charles University to the modern higher education system" and "2. The higher education system 1948-1989") the author gives an historical overview over the sytem of higher education in CSFR, whereas he covers the following aspects in the second chapter: "Basic data on higher education", "Organization and structure of the course of studies" and "Developments after 1989 and future trends". (DIPF/ ssch.)

  20. Synthesis, spectroscopic, computational (DFT/B3LYP), AChE inhibition and antioxidant studies of imidazole derivative

    Science.gov (United States)

    Ahmad, Faheem; Alam, Mohammad Jane; Alam, Mahboob; Azaz, Shaista; Parveen, Mehtab; Park, Soonheum; Ahmad, Shabbir

    2018-01-01

    The present study reports the synthesis and evaluation of biological properties of 3a,8a-dihydroxy-8-oxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-2(1H)-iminium chloride (3). The structure was confirmed by the FTIR, NMR, MS, CHN microanalysis and X-ray crystallographic analysis. Quantum chemical calculations have been performed at B3LYP-D3/6-311++G(d,p) level of theory to study the molecular geometry, IR, (1H and 13C) NMR, UV/Vis spectra and other molecular parameters of the asymmetric unit of crystal of imidazole compound (3). An empirical dispersion correction to hybrid functional (B3LYP-D3) has been incorporated in the present calculations due to presence of non-covalent interaction, Cl⋯H-O, in the present compound. The remarkable agreement has been observed between theoretical data and those measured experimentally. Moreover, the Hirshfeld analysis was carried out to ascertain the secondary interactions and associated 2D fingerprint plots. The synthesized imidazole derivative showed promising antioxidant property and inhibitory activity against acetylcholinesterase (AChE). Molecular docking was also performed in order to explain in silico antioxidant studies and to ascertain the probable binding mode of compound with the amino acid residues of protein.

  1. Education Fever and Happiness in Korean Higher Education

    Science.gov (United States)

    Lee, Jeong-Kyu

    2017-01-01

    This article discusses relevance between education fever and happiness from the viewpoint of Korean higher education. To review this study systematically, three research questions are addressed. First, what is education fever from the viewpoint of the Korean people? Second, what are relations between education fever and happiness? Last, can…

  2. Navigating in higher education

    DEFF Research Database (Denmark)

    Thingholm, Hanne Balsby; Reimer, David; Keiding, Tina Bering

    Denne rapport er skrevet på baggrund af spørgeskemaundersøgelsen – Navigating in Higher Education (NiHE) – der rummer besvarelser fra 1410 bachelorstuderende og 283 undervisere fordelt på ni uddannelser fra Aarhus Universitet: Uddannelsesvidenskab, Historie, Nordisk sprog og litteratur, Informati......Denne rapport er skrevet på baggrund af spørgeskemaundersøgelsen – Navigating in Higher Education (NiHE) – der rummer besvarelser fra 1410 bachelorstuderende og 283 undervisere fordelt på ni uddannelser fra Aarhus Universitet: Uddannelsesvidenskab, Historie, Nordisk sprog og litteratur...

  3. Assessment and Feedback in Higher Education: A Review of Literature for the Higher Education Academy

    Science.gov (United States)

    Jackel, Brad; Pearce, Jacob; Radloff, Ali; Edwards, Daniel

    2017-01-01

    This literature review has been undertaken for the Higher Education Academy (HEA). It explores recent scholarly contributions in the area of assessment and feedback in higher education (HE). As outlined in the HEA's terms of reference for this work, the contents of this review are designed to "help practitioners, policy makers and researchers…

  4. Effective Communication in Higher Education

    Science.gov (United States)

    Howard, Melissa

    2014-01-01

    The intent for this paper is to show that communication within the higher education field is a current problem. By looking first at the different styles, forms, and audiences for communication, the reader will hopefully gain perspective as to why this is such a problem in higher education today. Since the Millennial generation is the newest set of…

  5. Higher Education and Ethical Value

    Science.gov (United States)

    Lee, Jeong-Kyu

    2017-01-01

    The purpose of this study is to explore the importance of ethical value in higher education as well as the relevance between ethical value and higher education. In order to examine the study logically, three research questions are addressed: First, what is value, ethical value, and Asiatic ethical value? Second, for whom and what is higher…

  6. Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs.

    Directory of Open Access Journals (Sweden)

    Alexander Kuryatov

    Full Text Available Functional α7 nicotinic acetylcholine receptors (AChRs do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these subunits remain improperly assembled. Thus, additional chaperone proteins are probably required for efficient assembly of α7 AChRs. Cholinergic ligands can act as pharmacological chaperones to promote assembly of mature AChRs and upregulate the amount of functional AChRs. In addition, we have found that the chemical chaperones 4-phenylbutyric acid (PBA and valproic acid (VPA greatly increase the amount of functional α7 AChRs produced in a cell line expressing both α7 and RIC-3. Increased α7 AChR expression allows assay of drug action using a membrane potential-sensitive fluorescent indicator. Both PBA and VPA also increase α7 expression in the SH-SY5Y neuroblastoma cell line that endogenously expresses α7 AChRs. VPA increases expression of endogenous α7 AChRs in hippocampal neurons but PBA does not. RIC-3 is insufficient for optimal assembly of α7 AChRs, but provides assay conditions for detecting additional chaperones. Chemical chaperones are a useful pragmatic approach to express high levels of human α7 AChRs for drug selection and characterization and possibly to increase α7 expression in vivo.

  7. Reconfiguring the Higher Education Value Chain

    Science.gov (United States)

    Pathak, Virendra; Pathak, Kavita

    2010-01-01

    Forces of demand and supply are changing the dynamics of the higher education market. Transformation of institutions of higher learning into competitive enterprise is underway. Higher education institutions are seemingly under intense pressure to create value and focus their efforts and scarce funds on activities that drive up value for their…

  8. Mechanisms of educational space organizationing higher educational institutions of Ukraine

    OpenAIRE

    Hmyrova A.

    2017-01-01

    In the article the problems of public administration of the educational process in higher educational institutions of Ukraine, its social, legal, and managerial aspects have been analysed. The systematization and organization of the educational process in higher educational institutions of Ukraine have been considered, the main problems of the determined process have been outlined.

  9. Achieving the Texas Higher Education Vision

    National Research Council Canada - National Science Library

    Benjamin, Roger

    2000-01-01

    The Texas higher education system faces severe challenges in responding to the twin demands placed on it by economic growth and by the increasing problems of access to higher education that many Texans experience...

  10. Modern Higher Education Students within a Non-Traditional Higher Education Space: Not Fitting In, Often Falling Out

    Science.gov (United States)

    Mc Taggart, Breda

    2016-01-01

    A growing number of studies are focusing on the "fit" between the higher education student and the educational institution. These studies show that a lack of fit between the two generates anxiety, ultimately acting as a barrier to student learning. Research involving 23 higher education students attending a dual-sector further and higher…

  11. Discipline and Methodology in Higher Education Research

    Science.gov (United States)

    Tight, Malcolm

    2013-01-01

    Higher education research is a multidisciplinary field, engaging researchers from across the academy who make use of a wide range of methodological approaches. This article examines the relation between discipline and methodology in higher education research, analysing a database of 567 articles published in 15 leading higher education journals…

  12. Implementation of cloud computing in higher education

    Science.gov (United States)

    Asniar; Budiawan, R.

    2016-04-01

    Cloud computing research is a new trend in distributed computing, where people have developed service and SOA (Service Oriented Architecture) based application. This technology is very useful to be implemented, especially for higher education. This research is studied the need and feasibility for the suitability of cloud computing in higher education then propose the model of cloud computing service in higher education in Indonesia that can be implemented in order to support academic activities. Literature study is used as the research methodology to get a proposed model of cloud computing in higher education. Finally, SaaS and IaaS are cloud computing service that proposed to be implemented in higher education in Indonesia and cloud hybrid is the service model that can be recommended.

  13. Branding Canadian Higher Education. CBIE Research

    Science.gov (United States)

    Kizilbash, Zainab

    2011-01-01

    The branding of national higher education systems is a global trend that has become increasingly common over the last decade. One of the main motives driving this trend is the view that branding a national higher education system will increase that country's market share of international students. This is evident as national higher education…

  14. An overview of American higher education.

    Science.gov (United States)

    Baum, Sandy; Kurose, Charles; McPherson, Michael

    2013-01-01

    This overview of postsecondary education in the United States reviews the dramatic changes over the past fifty years in the students who go to college, the institutions that produce higher education, and the ways it is financed. The article, by Sandy Baum, Charles Kurose, and Michael McPherson, creates the context for the articles that follow on timely issues facing the higher education community and policy makers. The authors begin by observing that even the meaning of college has changed. The term that once referred primarily to a four-year period of academic study now applies to virtually any postsecondary study--academic or occupational, public or private, two-year or four-year-- that can result in a certificate or degree. They survey the factors underlying the expansion of postsecondary school enrollments; the substantial increases in female, minority, disadvantaged, and older students; the development of public community colleges; and the rise of for-profit colleges. They discuss the changing ways in which federal and state governments help students and schools defray the costs of higher education as well as more recent budget tensions that are now reducing state support to public colleges. And they review the forces that have contributed to the costs of producing higher education and thus rising tuitions. The authors also cite evidence on broad measures of college persistence and outcomes, including low completion rates at community and for-profit colleges, the increasing need for remedial education for poorly prepared high school students, and a growing gap between the earnings of those with a bachelor's degree and those with less education. They disagree with critics who say that investments in higher education, particularly for students at the margin, no longer pay off. A sustained investment in effective education at all levels is vital to the nation's future, they argue. But they caution that the American public no longer seems willing to pay more for

  15. Technology development: imperatives for higher education | Broere ...

    African Journals Online (AJOL)

    There is a major drive in South Africa to reshape the higher educational landscape, but traditional higher education at public contact institutions is certainly not geared to make an optimal contribution to this development in its present form. The question can be asked whether South Africa's higher education institutions (HEIs) ...

  16. The Emergent Terrains of "Higher Education Regionalism": How and Why Higher Education Is an Interesting Case for Comparative Regionalism

    Science.gov (United States)

    Chou, Meng-Hsuan; Ravinet, Pauline

    2016-01-01

    The introduction of regional political initiatives in the higher education sector symbolizes one of the many aspects of the changing global higher education landscape. Remarkably, these processes have generally escaped comparative scrutiny by scholars researching higher education policy cooperation or regional integration. In this article, we…

  17. Transforming Higher educational institution administration through ICT

    OpenAIRE

    J. Meenakumari; Dr. R. Krishnaveni

    2011-01-01

    The rapid development in Indian higher education sector has increased the focus on reforms in higher educational institution administration. Efficiency and accountability have become important elements, and the integration of Information and Communication Technology (ICT) into the educational administration process has become a necessity. The objective of this study is to know the current extent of ICT integration in Indian higher education institutions. The factors contributing to the succes...

  18. How to Pay for Higher Education.

    Science.gov (United States)

    Killingsworth, Charles C.

    The financial crisis for institutions of higher education is deepening. Higher tuition rates may be one of the answers, but this would exclude even more young people from attending college because of inability to pay, at a time when greater equality of opportunity in higher education has become an important goal. Federal support has helped but not…

  19. Four Impediments to Embedding Education for Sustainability in Higher Education

    Science.gov (United States)

    Gale, Fred; Davison, Aidan; Wood, Graham; Williams, Stewart; Towle, Nick

    2015-01-01

    Higher education institutions have an unavoidable responsibility to address the looming economic, environmental and social crises imperilling humans and ecosystems by placing "education for sustainability" at the heart of their concerns. Yet, for over three decades, the practice of 'higher education for sustainability' (HEfS) has…

  20. Commercialization of higher education: characteristics and trends

    Directory of Open Access Journals (Sweden)

    M. V. Klyov

    2014-04-01

    Much attention is given to the variety of approaches to the study of higher education. Today, sociological discourses used to analyze modern innovation in the education sphere, such as multiculturalism, diversification, confessionalization, regionalization, cosmopolitan atmosphere in the modern world, including the global information technology to the higher education. In the course of innovation and modernization of higher education, commercialization becomes significantly prevalent a phenomenon and a social process of educational institutions, which requires considerable research. The review of the US and European models of higher education makes it possible to understand the essence of appearance in the literature of such concepts as «academic capitalism», «university of market­type» and «entrepreneurial University», analyze relation to the appearance of private education and income and define the priority of commercialization. Indisputably, with both positive and negative, as a result of the reform of higher education appeared the peculiar environment of business education, which requires the existence of new rules of interaction, status­role relationships, values and norms . In some extent, commercialization is a transformation of knowledge into a commodity (speaking in the context of consumer society; however, it is the growing influence of market relations on the purpose and objectives of higher education, the growth of the importance of knowledge as a resource for economic development that focuses on  the concept of an economy based on knowledge.

  1. Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast

    International Nuclear Information System (INIS)

    Orlandi, Ivan; Casatta, Nadia; Vai, Marina

    2012-01-01

    ACH1 encodes a mitochondrial enzyme of Saccharomyces cerevisiae endowed with CoA-transferase activity. It catalyzes the CoASH transfer from succinyl-CoA to acetate generating acetyl-CoA. It is known that ACH1 inactivation results in growth defects on media containing acetate as a sole carbon and energy source which are particularly severe at low pH. Here, we show that chronological aging ach1Δ cells which accumulate a high amount of extracellular acetic acid display a reduced chronological lifespan. The faster drop of cell survival is completely abrogated by alleviating the acid stress either by a calorie restricted regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Moreover, the short-lived phenotype of ach1Δ cells is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis. A similar pattern of endogenous severe oxidative stress is observed when ach1Δ cells are cultured using acetic acid as a carbon source under acidic conditions. On the whole, our data provide further evidence of the role of acetic acid as cell-extrinsic mediator of cell death during chronological aging and highlight a primary role of Ach1 enzymatic activity in acetic acid detoxification which is important for mitochondrial functionality.

  2. Resistance to change in Greek higher education

    OpenAIRE

    Kremmyda, Stamatia

    2015-01-01

    This thesis is a study of resistance to the changes in Greek higher education that were implemented within the framework of the 1999 Bologna Agreement of the European Union in the period 2007-2008. The changes that occurred were of great significance for Greece’s education system as they introduced important changes in the structure and function of Greek higher education. This thesis argues that the organisational culture that had been created throughout the history of Greek higher education ...

  3. Academically Ambitious and Relevant Higher Education Research: The Legacy of the Consortium of Higher Education Researchers

    Science.gov (United States)

    Teichler, Ulrich

    2013-01-01

    The Consortium of Higher Education Researchers (CHER) was founded in 1988 to stimulate international communication and collaboration of higher education researchers. A need was felt to offset the isolation of the small numbers of scholars in this area of expertise in many countries, as well as the isolation of individual disciplines addressing…

  4. Is Higher Education Economically Unsustainable? An Exploration of Factors That Undermine Sustainability Assessments of Higher Education

    Science.gov (United States)

    Maragakis, Antonios; van den Dobbelsteen, Andy; Maragakis, Alexandros

    2016-01-01

    As students continue to review the sustainability of higher education institutions, there is a growing need to understand the economic returns of degrees as a function of a sustainable institution. This paper reviews a range of international research to summarize the economic drivers of higher education attainment. Although the cost inputs to…

  5. The Roles of Higher Education in Economic Development: Challenges and Prospects of Nigerian Higher Education Institutions

    Science.gov (United States)

    Njoku, Chimezie; Anyanwu, Jerome; Kaegon, Lies Elizabeth

    2014-01-01

    The focus of this paper was on the roles of Higher Education Institutions (HEIs) especially universities in economic development, paying particular attention to the challenges and prospects of the Nigerian Universities. The role of higher education as a major driver of economic development is well established, and this role will increase as…

  6. Higher Education Language Policy

    DEFF Research Database (Denmark)

    Lauridsen, Karen M.

    2013-01-01

    Summary of recommendations HEIs are encouraged, within the framework of their own societal context, mission, vision and strategies, to develop the aims and objectives of a Higher Education Language Policy (HELP) that allows them to implement these strategies. In this process, they may want......: As the first step in a Higher Education Language Policy, HEIs should determine the relative status and use of the languages employed in the institution, taking into consideration the answers to the following questions:  What is/are the official language(s) of the HEI?  What is/are the language...... and the level of internationalisation the HEI has or wants to have, and as a direct implication of that, what are the language proficiency levels expected from the graduates of these programme?  Given the profile of the HEI and its educational strategies, which language components are to be offered within...

  7. FACEBOOK COMMUNICATION IN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Emanuela Maria AVRAM

    2014-11-01

    Full Text Available The social networks have been growing steadily in recent years. Facebook, one of the most popular social networks, is a modern means of communication and socialization that has taken lately more ground in higher education becoming an important academic tool in the communication process. Many universities have their own Facebook page, being used by both students and teachers, and creating Facebook groups increasingly facilitates communication with students. Thus, this paper aims to identify the importance that Facebook holds in the academic communication process and highlights the implications it has in higher education. The results reveal that this type of communication has gained more ground in academia creating real social communities, and students use it more and more for collaboration in various activities involved in the higher education system, but also for socializing and information.

  8. Information Base of Financial Analysis of Educational Institutions of Higher Education

    Directory of Open Access Journals (Sweden)

    Alexander A. Galushkin

    2015-12-01

    Full Text Available In this article author analyzes issues related to the formation of information base analysis of the financial condition of educational institutions of higher education. Author notes that are significantly different principles of financial (accounting statements of non-governmental and government (budget of educational institutions of higher professional education. In conclusion, author notes that when analyzing the financial condition of the group of higher professional education institutions, they can be classified into subgroups, depending on the benefits of a species (subspecies of funding and revenue.

  9. Shared Leadership Transforms Higher Education IT

    Science.gov (United States)

    Duin, Ann Hill; Cawley, Steve; Gulachek, Bernard; O'Sullivan, Douglas M.; Wollner, Diane

    2011-01-01

    Globalization, immersive research and learning environments, unlimited access to information and analytics, and fiscal realities continue to impact higher education--and higher education IT. Although IT organizations face immense pressure to meet significantly greater expectations at significantly less cost, with such pressure comes the…

  10. What Role for Private Higher Education in Europe?

    DEFF Research Database (Denmark)

    Teixeira, Pedro N.; Biscaia, Ricardo; Rocha, Vera

    2016-01-01

    In recent decades, we have seen the emergence of private higher education in many European countries. This has been associated with the waves of significant expansion of the higher education system and with changes in regulation patterns, which have promoted a growing private-like behavior...... of public higher education institutions and the development of private provision in several European countries. The aim of this text is to discuss the relevance of the various dimensions of privatization in European higher education and to explore the relationship between public and private sectors...... in several European countries. This analysis points out some major patterns of the private higher education sector in Europe and reflects about the major issues faced by those systems regarding the potential contribution of private higher education....

  11. Playful learning in higher education

    DEFF Research Database (Denmark)

    Nørgård, Rikke Toft; Toft-Nielsen, Claus; Whitton, Nicola

    2017-01-01

    in higher education through the metaphor of the ‘magic circle’. This approach stimulates intrinsic motivation and educational drive, creates safe spaces for academic experimentation and exploration, and promotes reflective risk-taking, ideation, and participation in education. We present a model of playful......Increased focus on quantifiable performance and assessment in higher education is creating a learning culture characterised by fear of failing, avoidance of risk, and extrinsic goal-oriented behaviours. In this article, we explore possibilities of a more playful approach to teaching and learning...... learning, drawing on notions of signature pedagogies, field literature, and two qualitative studies on learner conceptions of enjoyment and reasons for disengagement. We highlight the potential of this approach to invite a different mind-set and environment, providing a formative space in which failure...

  12. Competition and Performance in European Higher Education

    DEFF Research Database (Denmark)

    Teixeira, Pedro; Biscaia, Ricardo; Rocha, Vera

    2014-01-01

    Higher education institutions face today a demanding and complex context in which they are asked to fulfill multiple roles. Many of these challenges have to be faced in a complex financial context in which traditional modes of funding have been transformed and public sources are not as generous...... as they often were in the past.Like in many other public services, in recent years it became a rather common statement that higher education institutions should be more efficient in the use of taxpayers’ resources, which had a clear impact in visible changes in the funding of public higher education in Europe....... In this paper we will analyse the major trends in higher education funding in Europe and underline to what extent the current debates about higher education and its funding have been significantly influenced by economic considerations. We will identify some of the main issues that dominate the current debate...

  13. Characteristics of the higher education system

    NARCIS (Netherlands)

    Jongbloed, Benjamin W.A.; Sijgers, Irene; Hammer, Matthijs; ter Horst, Wolf; Nieuwenhuis, Paul; van der Sijde, Peter

    2005-01-01

    This chapter presents an overview of the main characteristics of the higher education system in the Netherlands. Section 2.1 presents some key facts about the system as a whole (types of institutions, number of students, degrees). Section 2.2 discusses the different types of higher education

  14. Competitive Intelligence: Significance in Higher Education

    Science.gov (United States)

    Barrett, Susan E.

    2010-01-01

    Historically noncompetitive, the higher education sector is now having to adjust dramatically to new and increasing demands on numerous levels. To remain successfully operational within the higher educational market universities today must consider all relevant forces which can impact present and future planning. Those institutions that were…

  15. 34 CFR 600.4 - Institution of higher education.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Institution of higher education. 600.4 Section 600.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION INSTITUTIONAL ELIGIBILITY UNDER THE HIGHER EDUCATION ACT OF 1965, AS...

  16. Quality Management in Higher Education

    OpenAIRE

    Svoboda, Petr

    2017-01-01

    The thesis deals with quality management theory as an important part of management science. The primary objective of this work is an identification, formulation and analysis of such managerial issues in quality of higher education, which either are not known, or whose resolution is not considered fully sufficient. The thesis contains a bibliography of more than 200 related scientific works and presents selected issues of quality management in higher education, such as quality perception or it...

  17. GLOBALIZATION’S ASPECTS OF HIGHER EDUCATION COMMERCIALIZATION

    Directory of Open Access Journals (Sweden)

    O. Zhylinska

    2013-05-01

    Full Text Available The article is devoted to higher education current trends in the context of commercialization under globalization. The paper analyzes dynamics of the global education market, identifies factors that influence the choice of university and educational programs abroad. The importance of world universities rankings as information products that reflect the quality of education is shown. The study characterizes Ukrainian realities of globalization’s activation in higher education.

  18. Older Adults' Motivation to Learn in Higher Education

    Science.gov (United States)

    Lin, Yi-Yin

    2011-01-01

    A limited amount of literature has discussed older adults in formal education, especially their motivations to learn in higher education. This study aims to understand older adults' learning in the context of higher education. Specifically, this study argues that higher education can function as a stimulating learning environment that helps older…

  19. Higher Education--The Flexible Employment Sector?

    Science.gov (United States)

    Scott, Jill; Ridgley, Clare; Spurgeon, Peter

    2003-01-01

    Explored the extent to which policies and practices promoting work-life balance (family friendly policies) have been taken up within the English higher education sector. Responses from 50 higher education institutions show that flexible working practices are more widespread than the formal policies of institutions would suggest. (SLD)

  20. Quality Street: Encountering Higher Education's Accountabilities

    Science.gov (United States)

    Leihy, Peodair; Salazar, José Miguel

    2017-01-01

    This article offers a new approach to quality, focusing on the dimensions that gather around it. The mismatched goals of controlling and improving higher education continue to trouble the conceptual clarity of accountability. Quality in higher education emerges as something agreed upon (to varying efficacy) through accountability measures, rather…

  1. Black Student Retention in Higher Education.

    Science.gov (United States)

    Lang, Marvel, Ed.; Ford, Clinita A., Ed.

    This collection focuses on problems in the recruitment, enrollment and retention of Blacks in higher education in America. The following chapters are provided: "The Black Student Retention Problem in Higher Education: Some Introductory Perspectives" (Marvel Lang); "Early Acceptance and Institutional Linkages in a Model Program of Recruitment,…

  2. Is Higher Education in "Really" "Internationalising"?

    Science.gov (United States)

    Healey, Nigel M.

    2008-01-01

    It is a widely accepted maxim that, like business generally, higher education is globalising. For many countries, higher education is now an important export sector, with university campuses attracting international students from around the world. Licensing production, in the form of franchising degree provision to international partners, is…

  3. Higher Education: Teach Happiness and Wisdom

    Science.gov (United States)

    Lee, Jeong-Kyu

    2017-01-01

    The purpose of this article is to examine why a university should teach happiness and wisdom from religious perspectives. To explore this paper systematically, three research questions are addressed. First, why higher education institutions should teach happiness? Second, why higher education institutions should teach wisdom? Third, how ethical…

  4. Venezuela: Higher education, neoliberalism and socialism

    NARCIS (Netherlands)

    Muhr, T.; Verger, A.; Hill, David; Rosskam, Ellen

    2008-01-01

    In this chapter we analyse the Higher Education For All (HEFA) policies and practices in the Bolivarian Republic of Venezuela. In the construction of a 21st Century Socialism, universal access to higher education has not only become a constitutional right but assumes a pivotal role in both the

  5. OPTIMIZATION OF FINANCING PUBLIC HIGHER EDUCATION INSTITUTIONS IN UKRAINE

    Directory of Open Access Journals (Sweden)

    Z. Varnaliy

    2017-09-01

    Full Text Available The paper considers the ways to optimize financing public higher education institutions of Ukraine. Public higher education institutions acutely feel the lack of financial resources. The study describes that it is necessary to reform the models, methods and forms of financing higher education institutions. The paper explains the impact of autonomy of higher education institutions on their development. The autonomy level of university determines the possibilities for diversification from additional sources. The results found that more autonomy of higher education institutions will allow them effectively generate and use financial resources. The review outlines the diversification of financial resources public universities. One of the key factors of the university success is to implement the diversification strategy into the overall academic strategy and mission of the higher education institution. The analysis recommends the performance-based funding system and public higher education institutions achieve certain performance indicators. The performance-based funding system will promote higher competitiveness of education institutions and improve the quality of higher education in general. The conclusions suggest the development trends of financing public higher education institutions of Ukraine.

  6. BUSINESS MODEL INNOVATION IN NIGERIAN HIGHER EDUCATION INSTITUTIONS

    OpenAIRE

    Nonso Ochinanwata; Patrick Oseloka Ezepue

    2017-01-01

    This paper explores business model innovation that aims to innovate the Nigerian higher education sector. A focus group and semi-structured interviews among higher education Nigerian academics, students and graduates are used to explore the new business model for Nigerian higher education. The study found that, to achieve efficient and effective innovation, Nigerian higher education institutions need to collaborate with industry, professionals and other stakeholders, such as company managemen...

  7. Designing Social Media into Higher Education Courses

    OpenAIRE

    Thapanee Seechaliao

    2015-01-01

    This research paper presents guiding on how to design social media into higher education courses. The research methodology used a survey approach. The research instrument was a questionnaire about guiding on how to design social media into higher education courses. Thirty-one lecturers completed the questionnaire. The data were scored by frequency and percentage. The research results were the lecturers' opinions concerning the designing social media into higher education ...

  8. Changing Concepts of Equity in Transforming UK Higher Education: Implications for Future Pedagogies and Practices in Global Higher Education

    Science.gov (United States)

    David, Miriam E.

    2011-01-01

    This paper is about changing concepts of equity in UK higher education. In particular, it charts the moves from concepts about gender equality as about women's education as a key issue in twentieth century higher education to questions of men's education in the twenty-first century. These changing concepts of equity are linked to wider social and…

  9. Program on Administration in Higher Education.

    Science.gov (United States)

    Karadima, Oscar

    The importance of developing a university level program on administration in higher education in Latin America is discussed. The objective of such a program would provide training to faculty and higher level education and administrative staff in matters related to administration. The program would offer the necessary guidelines in dealing with…

  10. Acetylcholinesterase Inhibitors (AChEI's for the treatment of visual hallucinations in schizophrenia: A review of the literature

    Directory of Open Access Journals (Sweden)

    Patel Sachin S

    2010-09-01

    Full Text Available Abstract Background Visual hallucinations occur in various neurological diseases, but are most prominent in Lewy body dementia, Parkinson's disease and schizophrenia. The lifetime prevalence of visual hallucinations in patients with schizophrenia is much more common than conventionally thought and ranges from 24% to 72%. Cortical acetylcholine (ACh depletion has been associated with visual hallucinations; the level of depletion being related directly to the severity of the symptoms. Current understanding of neurobiological visual processing and research in diseases with reduced cholinergic function, suggests that AChEI's may prove beneficial in treating visual hallucinations. This offers the potential for targeted drug therapy of clinically symptomatic visual hallucinations in patients with schizophrenia using acetylcholinesterase inhibition. Methods A systematic review was carried out investigating the evidence for the effects of AChEI's in treating visual hallucinations in Schizophrenia. Results No evidence was found relating to the specific role of AChEI's in treating visual hallucinations in this patient group. Discussion Given the use of AChEI's in targeted, symptom specific treatment in other neuropsychiatric disorders, it is surprising to find no related literature in schizophrenia patients. The use of AChEI's in schizophrenia has investigated effects on cognition primarily with non cognitive effects measured more broadly. Conclusions We would suggest that more focused research into the effects of AChEI's on positive symptoms of schizophrenia, specifically visual hallucinations, is needed.

  11. The Worldwide Growth of Private Higher Education: Cross-National Patterns of Higher Education Institution Foundings by Sector

    Science.gov (United States)

    Buckner, Elizabeth

    2017-01-01

    This article investigates cross-national patterns of public and private higher education institution (HEI) foundings from 1960 to 2006. It argues that in addition to national demographic and economic factors, patterns of HEI foundings also reflect world-level models about how nations should structure their higher education systems. Findings…

  12. Preparation and comparison of a-C:H coatings using reactive sputter techniques

    Energy Technology Data Exchange (ETDEWEB)

    Keunecke, M., E-mail: martin.keunecke@ist.fraunhofer.d [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany); Weigel, K.; Bewilogua, K. [Fraunhofer Institute for Surface Engineering and Thin Films (IST), Braunschweig (Germany); Cremer, R.; Fuss, H.-G. [CemeCon AG, Wuerselen (Germany)

    2009-12-31

    Amorphous hydrogenated carbon (a-C:H) coatings are widely used in several industrial applications. These coatings commonly will be prepared by plasma activated chemical vapor deposition (PACVD). The main method used to prepare a-C:H coating in industrial scale is based on a glow discharge in a hydrocarbon gas like acetylene or methane using a substrate electrode powered with medium frequency (m.f. - some 10 to 300 kHz). Some aims of further development are adhesion improvement, increase of hardness and high coating quality on complex geometries. A relatively new and promising technique to fulfil these requirements is the deposition of a-C:H coatings by a reactive d.c. magnetron sputter deposition from a graphite target with acetylene as reactive gas. An advancement of this technique is the deposition in a pulsed magnetron sputter process. Using these three mentioned techniques a-C:H coatings were prepared in the same deposition machine. For adhesion improvement different interlayer systems were applied. The effect of different substrate bias voltages (d.c. and d.c. pulse) was investigated. By applying the magnetron sputter technique in the d.c. pulse mode, plastic hardness values up to 40 GPa could be reached. Besides hardness other mechanical properties like resistance against abrasive wear were measured and compared. Cross sectional SEM images showed the growth structure of the coatings.

  13. Confronting the dark side of higher education

    DEFF Research Database (Denmark)

    Bengtsen, Søren Smedegaard; Barnett, Ronald

    2017-01-01

    within higher education is not a symptom we should fear and avoid. Having the ability and courage to face these darker educational aspects of everyday higher education practice will enable students and teachers to find renewed hope in the university as an institution for personal as well as professional......In this paper we philosophically explore the notion of darkness within higher education teaching and learning. Within the present-day discourse of how to make visible and to explicate teaching and learning strategies through alignment procedures and evidence-based intellectual leadership, we argue...... that dark spots and blind angles grow too. As we struggle to make visible and to evaluate, assess, manage and organise higher education, the darkness of the institution actually expands. We use the term ‘dark’ to comprehend challenges, situations, reactions, aims and goals, which cannot easily be understood...

  14. 32 CFR 37.1305 - Institution of higher education.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Institution of higher education. 37.1305 Section... Institution of higher education. An educational institution that: (a) Meets the criteria in section 101 of the Higher Education Act of 1965 (20 U.S.C. 1001); and (b) Is subject to the provisions of OMB Circular A-110...

  15. 10 CFR 603.1280 - Institution of higher education.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Institution of higher education. 603.1280 Section 603.1280... Definitions of Terms Used in this Part § 603.1280 Institution of higher education. An educational institution that: (a) Meets the criteria in section 101 of the Higher Education Act of 1965 (20 U.S.C. 1001); and...

  16. The Dot.xxx Challenge to Higher Education.

    Science.gov (United States)

    Graves, William H.

    2000-01-01

    Describes some of the dimensions of the "e-cology" of Internet-based "e-Learning" in higher education. Discusses e-Learning service and operating dimensions; higher education's challenge to balance virtual and traditional educational delivery; instructor-led and instructor-less learning; the roles of content and instructor in instructor-led…

  17. Higher Education Tarred with a Harvard Brush.

    Science.gov (United States)

    Trachtenberg, Stephen Joel

    1987-01-01

    The Secretary of Education Bennett and Michael Kinsley in an article in the Wall Street Journal claim that colleges are wasteful and ineffective, but the picture they paint of American higher education is essentially mythical. Higher education is seen as a scapegoat for politicians in an election year. (MLW)

  18. National standards of pharmaceutical education in the context of reforming legislation of higher education

    Directory of Open Access Journals (Sweden)

    І. M. Alieksieieva

    2018-03-01

    Full Text Available Socially significant steps of Ukraine in the issue of European integration are measures to reform the legislation on higher education in the context of the Bologna process, namely: the adoption of the National Qualifications Framework and the new edition of the Law of Ukraine "On Higher Education." The National Qualifications Framework (NQF, 2011 provides for "the introduction of European standards and principles to ensure the quality of education, taking into account the requirements of the labor market to the competence of specialists." According to formal characteristics, NQF is a matrix with static support elements – descriptors, which determine the vector of movement to a specific goal. The legal basis for the modernization of educational activities and standards of higher education was the new edition of the Law of Ukraine "On Higher Education" (2014. The purpose of the article is a scientific and analytical study of the process of forming national standards for higher education, in particular, the standards of pharmaceutical higher education. Materials and methods. The study was based on the analysis of normative and legal and other normative acts on higher education, the issues of standardization of higher education and the systematization of qualifications, as well as scientific developments on this issue. Methods of research – bibliographic, linguistic, contextual, substantive-legal, comparative-legal, generalization, description of results. Results. Updating the wording of the Law of Ukraine "On Higher Education," which is the basic normative legal act of higher legal action in higher education, the adjustment of its basic principles, concepts and approaches, objectively entailed the renewal of the entire regulatory and legal framework regulating the organization of higher education. Equally, this also affected the standards of higher education. This issue in the Act is reserved Section III: Standards of educational activity and

  19. Factor 10 Visions project: Higher Education Sector Towards Sustainable Higher Education: Environmental impacts of campus-based and distance higher education systems

    OpenAIRE

    Roy, Robin; Potter, Stephen; Yarrow, Karen; Smith, Mark

    2005-01-01

    This report gives the findings of a major UK study of the environmental impacts of four different methods of providing higher education (HE) courses: Conventional campus-based full-time courses; Conventional campus-based part-time courses; Print-based distance taught courses; Part electronically-delivered distance taught courses.\\ud This is an environmental assessment of these different HE systems and does not assess their educational effectiveness or socio-economic costs and benefits.\\ud KEY...

  20. Who Is Missing from Higher Education?

    Science.gov (United States)

    Gorard, Stephen

    2008-01-01

    This paper discusses the difficulties of establishing a clear count of UK higher education students in terms of the categories used for widening participation, such as occupational background or ethnicity. Using some of the best and most complete data available, such as the annual figures from the Higher Education Statistics Agency, the paper then…

  1. Who Should Pay for Higher Education?

    Science.gov (United States)

    Bou-Habib, Paul

    2010-01-01

    Policies that shift the costs of higher education from the taxpayer to the university student or graduate are increasingly popular, yet they have not been subjected to a thorough normative analysis. This paper provides a critical survey of the standard arguments that have been used in the public debate on higher education funding. These arguments…

  2. Cost Efficiency in Public Higher Education.

    Science.gov (United States)

    Robst, John

    This study used the frontier cost function framework to examine cost efficiency in public higher education. The frontier cost function estimates the minimum predicted cost for producing a given amount of output. Data from the annual Almanac issues of the "Chronicle of Higher Education" were used to calculate state level enrollments at two-year and…

  3. New Ways to Finance Higher Education

    Science.gov (United States)

    Lingens, Hans G., Ed.

    2004-01-01

    Germany ranks in the bottom fourth in spending on higher education in a comparison among Western industrial countries. Germany's status as a place for higher education is imperiled. There is a danger that in the near future, the very best and most promising of the upcoming generations will increasingly choose only professionally relevant training…

  4. ERP for Romanian Higher Education

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available Also most of the big ERP providers provide solutions for higher education, including SAP AG, Oracle, JD Eduards, Peoplesoft, universities preferr other specialized applications which better fit their specific needs. This paper presents the advantages of an integrated solution for higher education and analyzes the solutions offered for this sector by the Romanian ERP market. The conlusion is more like an invitation to discussion about possible solutions to the present Romanian university situation: low budgets, changing regulations, isolated, self-developed applications.

  5. Can Distance Education Increase Educational Equality? Evidence from the Expansion of Chinese Higher Education

    Science.gov (United States)

    Li, Fengliang; Zhou, Mengying; Fan, Baolong

    2014-01-01

    Since China decided to expand its higher education, we have seen an increasing number of discussions of the relationship between educational expansion and equality. However, few studies have examined whether the expansion of distance higher education will improve educational equality among different regions. In this study, we analyzed the changes…

  6. Higher Education in Scandinavia

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Andreasen, Lars Birch

    2015-01-01

    Higher education systems around the world have been undergoing fundamental changes through the last 50 years from more narrow self-sustaining universities for the elite and into mass universities, where new groups of students have been recruited and the number of students enrolled has increased...... an impact on the educational systems in Scandinavia, and what possible futures can be envisioned?...... dramatically. In adjusting to the role of being a mass educational institution, universities have been challenged on how to cope with external pressures, such as forces of globalization and international markets, increased national and international competition for students and research grants, increased...

  7. Makerere Journal of Higher Education - Vol 2 (2009)

    African Journals Online (AJOL)

    Makerere Journal of Higher Education. ... The University Staff Job Satisfaction Challenge and its Implications for National Council for Higher Education: An Empirical Evidence · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD ... Higher Education and Youth Preparation for the Labour Market: the case of Universities.

  8. Higher education institutions, regional labour markets and population development

    OpenAIRE

    Stambøl, Lasse Sigbjørn

    2011-01-01

    An important motivation to establish and develop higher education institutions across regions is to improve and restructure the regional labour markets toward higher education jobs, contribute to maintain the regional settlement patterns of the population generally and to increase the numbers of higher educated labour especially. This paper introduces a short description of the Norwegian regional higher education institution system, followed by analyses of the impact of higher education insti...

  9. Impact of On-line Education on Higher Education System

    OpenAIRE

    Sreeramana Aithal; Shubhrajyotsna Aithal

    2016-01-01

    Education is the most important thing for any country to develop and prosper. Education moulds the character and intelligence of individuals. It also provides the talent and motivation to every person. The conventional education system at higher education level is analogous to brick and mortar type business system, where a student gets a systematic education from college/University by personally attending required courses regularly (Full time/part Time). However, the conventional education sy...

  10. Impact of On-line Education on Higher Education System

    OpenAIRE

    Sreeramana Aithal; Shubhrajyotsna Aithal

    2016-01-01

    Education is the most important thing for any country to develop and prosper. Education moulds the character and intelligence of individuals. It also provides the talent and motivation to every person. The conventional education system at higher education level is analogous to brick and mortar type business system, where a student gets systematic education from college/University by personally attending required courses regularly (Full time/part Time). However, the conventional education syst...

  11. Asian Women in Higher Education: Shared Communities

    Science.gov (United States)

    Bhopal, Kalwant

    2010-01-01

    More Asian women are entering higher education in the UK than ever before, and the number looks likely to rise. Their engagement with higher education reflects widespread changes in the attitudes and cultural expectations of their various communities, as awareness grows of the greater long-term value associated with continuing in education. Today…

  12. Challenges in higher education for sustainability

    CERN Document Server

    Filho, Walter

    2016-01-01

    This book presents the latest advances on the incorporation of sustainability in higher education. Different aspects such as the environmental, economic and social are here discussed. Several examples illustrating how sustainability in higher education is being pursued in different countries can be found in this book. Case studies include institutions from Kosovo, Brazil, Portugal, UK, Canada and USA.

  13. Higher Education Institutions in India and its Management

    OpenAIRE

    Niradhar Dey

    2011-01-01

    Managing higher education institutions in India is just like a junction, how to show the path to the future nation builder of our country. There are very hue and cry situations/difficulties in present Indian higher education about what to do and what not to do. It becomes so sensitive that it creates conflict in inter and intra management of higher education institutions. In recent years there have been debates and controversies regarding management of higher education institutions so as to i...

  14. Statistical insights from Romanian data on higher education

    Directory of Open Access Journals (Sweden)

    Andreea Ardelean

    2015-09-01

    Full Text Available This paper aims to use cluster analysis to make a comparative analysis at regional level concerning the Romanian higher education. The evolution of higher education in post-communist period will also be presented, using quantitative traits. Although the focus is on university education, this will also include references to the total education by comparison. Then, to highlight the importance of higher education, the chi-square test will be applied to check whether there is an association between statistical regions and education level of the unemployed.

  15. Claiming Voice on the Future of Higher Education

    Science.gov (United States)

    Roper, Larry D.

    2016-01-01

    Higher education reform is a prominent topic among state and federal governments. However, the discussions regarding higher education are narrowly focused and not always inclusive of the voices of postsecondary leaders. Higher education officials must find approaches to ensure their voices are appropriately represented in these crucial…

  16. 7 CFR 3015.192 - Institutions of higher education.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Institutions of higher education. 3015.192 Section....192 Institutions of higher education. (a) OMB Circular No. A-21, including any amendments to the... activities conducted by institutions of higher education (other than for-profit institutions). (b) Additional...

  17. Financing higher education in South Africa: Public funding ...

    African Journals Online (AJOL)

    controversy. The article discusses these funding challenges. It argues that the current higher education funding conundrum will hamstring the achievement of the important higher education policy goals articulated in the National Plan on Higher Education. The article finally argues for a shift towards a redistributive funding ...

  18. Technologies of polytechnic education in global benchmark higher education institutions

    Science.gov (United States)

    Kurushina, V. A.; Kurushina, E. V.; Zemenkova, M. Y.

    2018-05-01

    The Russian polytechnic education is going through the sequence of transformations started with introduction of bachelor and master degrees in the higher education instead of the previous “specialists”. The next stage of reformation in the Russian polytechnic education should imply the growth in quality of teaching and learning experience that is possible to achieve by accumulating the best education practices of the world-class universities using the benchmarking method. This paper gives an overview of some major distinctive features of the foreign benchmark higher education institution and the Russian university of polytechnic profile. The parameters that allowed the authors to select the foreign institution for comparison include the scope of educational profile, industrial specialization, connections with the leading regional corporations, size of the city and number of students. When considering the possibilities of using relevant higher education practices of the world level, the authors emphasize the importance of formation of a new mentality of an engineer, the role of computer technologies in engineering education, the provision of licensed software for the educational process which exceeds the level of a regional Russian university, and successful staff technologies (e.g., inviting “guest” lecturers or having 2-3 lecturers per course).

  19. Collaborative virtual gaming worlds in higher education

    Directory of Open Access Journals (Sweden)

    Nicola Whitton

    2008-12-01

    Full Text Available There is growing interest in the use of virtual gaming worlds in education, supported by the increased use of multi-user virtual environments (MUVEs and massively multiplayer online role-playing games (MMORPGs for collaborative learning. However, this paper argues that collaborative gaming worlds have been in use much longer and are much wider in scope; it considers the range of collaborative gaming worlds that exist and discusses their potential for learning, with particular reference to higher education. The paper discusses virtual gaming worlds from a theoretical pedagogic perspective, exploring the educational benefits of gaming environments. Then practical considerations associated with the use of virtual gaming worlds in formal settings in higher education are considered. Finally, the paper considers development options that are open to educators, and discusses the potential of Alternate Reality Games (ARGs for learning in higher education. In all, this paper hopes to provide a balanced overview of the range of virtual gaming worlds that exist, to examine some of the practical considerations associated with their use, and to consider their benefits and challenges in learning and teaching in the higher education context.

  20. The case of higher education provision in further education: leadership in the evolution of higher education in the post leaving certificate sector of the city of Dublin vocational education committee.

    OpenAIRE

    Murray, Denis

    2015-01-01

    The case of Higher Education provision in Further Education: Leadership in the evolution of Higher Education in the Post Leaving Certificate sector of the City of Dublin Vocational Education Committee. (Denis Murray, BA, MBS.) This research investigates evolutionary change in Further Education (FE) within the Post Leaving Certificate (PLC) sector with a particular emphasis on the development of Higher Education (HE) courses within the CDVEC. The objective of the study is to understand what...

  1. Ontological simulation for educational process organisation in a higher educational institution

    Science.gov (United States)

    Berestneva, O. G.; Marukhina, O. V.; Bahvalov, S. V.; Fisochenko, O. N.; Berestneva, E. V.

    2017-01-01

    Following the new-generation standards is needed to form a task list connected with planning and organizing of an academic process, structure and content formation of degree programmes. Even when planning the structure and content of an academic process, one meets some problems concerning the necessity to assess the correlation between degree programmes and demands of educational and professional standards and to consider today’s job-market and students demands. The paper presents examples of ontological simulations for solutions of organizing educational process problems in a higher educational institution and gives descriptions of model development. The article presents two examples: ontological simulation when planning an educational process in a higher educational institution and ontological simulation for describing competences of an IT-specialist. The paper sets a conclusion about ontology application perceptiveness for formalization of educational process organization in a higher educational institution.

  2. Mergers in European Higher Education

    DEFF Research Database (Denmark)

    Rocha, Vera; Teixeira, Pedro N.; Biscaia, Ricardo

    2018-01-01

    In recent years, mergers have been widely used in higher education (HE) to achieve a variety of purposes, ranging from problems of institutional fragmentation to the lack of financial and academic viability, and low institutional efficiency and quality. However, despite a large stream of HE...... literature addressing those issues, there has been little attention to the link between funding-related problems and merger processes. Moreover, there is very little comparative research among different higher education systems experiencing those processes. In this paper, we map and characterize the recent...

  3. Optimal Admission to Higher Education

    DEFF Research Database (Denmark)

    Albæk, Karsten

    This paper constructs higher education admission rules that maximise graduation rates and thus increase the skill level of the work force. An application shows that students with a low level in mathematics in secondary school ought to find it easier to be admitted to an economics programme than...... to law or psychology programmes, even though economics is the most difficult programme from which to graduate without a strong background in mathematics. Indirect gains from optimal admission include the potential of making whole cohorts of students more able to graduate with a higher education degree....

  4. Analytical Chemistry in the European Higher Education Area European Higher Education

    DEFF Research Database (Denmark)

    the more specialized degree of the Euromaster. The aim of the process, as a part of the fulfilment of the Bologna Declaration, is to propose a syllabus for education at the highest level of competence in academia. The proposal is an overarching framework that is supposed to promote mobility and quality......A Eurobachelor degree of Chemistry was endorsed by the EuCheMS division of analytical chemistry in 2004, and it has since then been adopted by many European universities. In the second stage of the European Higher Education Area (EHEA) process of harmonization, there is now focus on developing...... hold positions where analytical chemistry is the primary occupation. The education within the EHEA offers subjects related to chemical analysis but not all universities offer courses on analytical chemistry as an independent scientific discipline. Accordingly, the recent development of the analytical...

  5. Nullifying quality: the marketasation of higher education

    DEFF Research Database (Denmark)

    Bendixen, Carsten; Jacobsen, Jens Christian

    2017-01-01

    higher education. In the long run it will hardly benefit educational programmes if institutions of higher educations fail to ‘stand for’ quality that, in the very least, can supplement the fulfilment of politically determined targets and standards. In this way the market will have not only graduates who......The increasing dominance of educational markets means that quality of higher education has the character of open signifiers of periodic occurrence, embedded institutionally as ways of consensual communication on how to go on as smoothly as possible. This promotes the growth of context dependent...... nullification processes. On the other hand, institutions have to adopt standards in education as a measure of outcome indicators for benchmarking. When quality is replaced by standards and if standards are equivalent to labour market relevance this might signal the beginning of overall external control over...

  6. Planning for Higher Education.

    Science.gov (United States)

    Lindstrom, Caj-Gunnar

    1984-01-01

    Decision processes for strategic planning for higher education institutions are outlined using these parameters: institutional goals and power structure, organizational climate, leadership attitudes, specific problem type, and problem-solving conditions and alternatives. (MSE)

  7. Reducing Math Obstacles to Higher Education

    Science.gov (United States)

    Dreyfus, Tony; Salomon-Fernandez, Yves

    2015-01-01

    The last few months have brought changes in the leadership of public education in Massachusetts. The new secretary of education and chair of the Board of Higher Education both have deep expertise in education reform and accountability, and broad experiences in business. This new leadership could bring momentum for a "systems approach" to…

  8. Higher Education Policies and Overeducation in Turkey

    Science.gov (United States)

    Habibi, Nader

    2017-01-01

    In the past two decades Turkey has experienced a rapid increase in higher education student enrollment. This sharp increase in access to higher education has satisfied a strong social demand for university education but it has led to a growing surplus of university graduates who cannot find adequate jobs. As a result Turkey has entered an…

  9. Neonikotinoid İnsektisitlere Bağlı Olarak Drosophila melanogaster’in AChE Aktivitesinde Meydana Gelen Değişikliklerin Bitkisel Ekstraktlar ile Giderilmesi Üzerine Araştırmalar

    Directory of Open Access Journals (Sweden)

    Sedat Ünver

    2014-12-01

    Full Text Available Bu çalışmada, Drosophila melanogaster’in ergin bireylerinde bulunan asetil kolinesteraz (AChE enzim aktivitesi üzerine İmidakloprid (İMİ ve Asetamiprid (ASE  insektisitlerinin etkileri araştırılmıştır. Ayrıca farklı bitkilere ait su ekstraktlarının (Salvia lavandulifolia, Hypericum scabrum, Capsella bursa-pastoris ve Teucrium orientale iyileştirici etkileri de in vivo olarak incelenmiştir. Bu amaçla iki deney grubu oluşturulmuştur. İlk deney grubunda ergin bireylere yalnızca farklı dozlarda insektisit (0,5; 1,0; 1,5 ve 2,0 ppm, diğer deney grubunda ise insektisit + bitki ekstraktları (1:1 v/v birlikte uygulanmıştır. Uygulamalar sonucunda insektisitler doz artışına bağlı olarak ergin bireylerde AChE aktivitesini artırmıştır (P<0,05. Ancak insektisitler bitkisel ekstraktlar ile birlikte uygulanınca enzim aktivitesi tekrar kontrol grubuna yaklaşmıştır (P<0,05.

  10. Towards a Sustainability Reporting Guideline in Higher Education

    Science.gov (United States)

    Huber, Sandra; Bassen, Alexander

    2018-01-01

    Purpose: So far, sustainability reporting in higher education is in a very early stage--partly, because of the lack of an established and widely recognized sustainability reporting framework for higher education institutions (HEIs). Therefore, a modification of the sustainability code for the use in the higher education context was recently…

  11. Assessment of the Quality Management Models in Higher Education

    Science.gov (United States)

    Basar, Gulsun; Altinay, Zehra; Dagli, Gokmen; Altinay, Fahriye

    2016-01-01

    This study involves the assessment of the quality management models in Higher Education by explaining the importance of quality in higher education and by examining the higher education quality assurance system practices in other countries. The qualitative study was carried out with the members of the Higher Education Planning, Evaluation,…

  12. Comparatives Korean and Mongolian Achievement In Higher Education

    OpenAIRE

    Uranchimeg Julia Agvaantseren; Park Sae Hoon

    2013-01-01

    The purpose of this paper is to introduce the transition of Korean higher education reform and to study of Korean and Mongolian experience and achievement in contemporary higher education. And also paper provides a description of the higher education in Mongolia in an effort to identify important financial issues and concern while comparing with Korean high education experience and tries to attract attention of policy makers for better alternative...

  13. Enhancing diversity through globalised higher education?

    DEFF Research Database (Denmark)

    Bengtsen, Søren Smedegaard; Nørgård, Rikke Toft; Locke, William

    for individual working patterns and career prospects. The fourth contribution discusses how globalisation, seen through the lense of the digitalised university, does not have to lead to uniformity in higher education learning and teaching practices, but may advance and bring forward local and personal life......, and the knowledge and skills developed transferrable (Francois, 2015; Nerad & Evans, 2014; Nerad & Heggelund, 2008). In these ways, universities are able to align educational policy, the production of social capital and higher education curricula. As a result, students are not confined to their home countries when...... academic practice, work, careers and cultures through a multi-layered analysis and discussion of the academic domains of: undergraduate education, doctoral education, junior and mid career academic work and careers, and inter-university digital communities. We ask: What are the meanings of local...

  14. Demystifying Educational Resilience: Barriers of Bahamian Nontraditional Adult Learners in Higher Education

    Science.gov (United States)

    Hunter-Johnson, Yvonne

    2017-01-01

    Within the past 30 years, the number of nontraditional learners who pursue higher education has increased. This gravitation to higher education can be attributed to the changing value of the nontraditional learner regarding higher education as a direct link to improving the quality of employment, family, and financial stability. Despite the desire…

  15. Toward Integral Higher Education Study Programs in the European Higher Education Area: A Programmatic and Strategic View

    Directory of Open Access Journals (Sweden)

    Markus Molz

    2009-12-01

    Full Text Available This essay somehow arbitrarily freezes my ongoing attempt to grasp the present situation and future possibilities of higher education courses, programs, institutions and initiatives that are inspired by integral and likeminded approaches. The focus in this essay is on the European Higher Education Area and its specifics, whereas some implicit or explicit comparisons with the USA are made. My reflections are triggered by the recurrent observation that in Europe there seems to be i more demand than offer of integrally oriented higher education programs, ii an imbalance between overused but little successful and underused but potentially more promising strategies to implement such programs, iii little or no learning from past failures, and iv little mutual awareness, communication and collaboration between different activists and initiatives in this field. The context for this essay is i the current societal macroshift, ii the unfolding of academic level integral and likeminded research worldwide, and iii the large scale reform of the European Higher Education systems brought about by the Bologna process, its (false promises and the potential it nevertheless has for realizing examples of a more integral higher education. On this basis the consequences for attempts to overcome a relatively stagnant state of affairs in Europe are discussed. Given that; most past attempts to implement programs inspired by an integral worldview have failed from the start, or disappeared after a relatively short period, or are marginalised or becoming remainstreamed, this essay aims to devise a potentially more promising strategic corridor and describes the contours of the results that could be brought about when following a developmental trajectory within this corridor. This futurising exercise is inspired by principles shared by many integral and likeminded approaches, especially the reconsideration, integration and transcendence of premodern, modern and postmodern

  16. Assessing Cyberbullying in Higher Education

    Science.gov (United States)

    Kamali, Ali

    2015-01-01

    This project aims to expose information educators to various aspects of cyberbullying for the purpose of policy development in an environment of higher education. The preponderance of nation-wide research on cyberbullying is concentrated on adolescents; such efforts in college campuses are limited to individual endeavors. Cyberbullying research on…

  17. For better, for worse: nursing in higher education.

    Science.gov (United States)

    Owen, G M

    1988-01-01

    In this paper the recently proposed developments in nursing education within the United Kingdom are discussed within a historical context. Since a number of nursing departments already exist within the higher education sector (comprising universities, polytechnics and colleges of technology), it is suggested that use should be made of the experience already gained by nurses working within higher education. The pros and cons of nurse education being provided in or associated with higher education are discussed. Theoretical perspectives from change theory are applied. The importance of educating the practitioner for a holistic and community-based role is stressed.

  18. Quality in Higher Education: United Arab Emirates Perspective

    Science.gov (United States)

    Soomro, Tariq Rahim; Ahmad, Reyaz

    2012-01-01

    Quality in higher education is the major concern among researchers. Managing quality in higher education in a multicultural population with different approaches is not only challenging but an uphill task. This paper will focus on quality concern in higher education keeping in view, the United Arab Emirates (UAE) perspectives. A model to maintain…

  19. Just Imaginary: Delimiting Social Inclusion in Higher Education

    Science.gov (United States)

    Gale, Trevor; Hodge, Steven

    2014-01-01

    This paper explores the notion of a "just imaginary" for social inclusion in higher education. It responds to the current strategy of OECD nations to expand higher education and increase graduate numbers, as a way of securing a competitive advantage in the global knowledge economy. The Australian higher education system provides the case…

  20. Does Higher Education Expansion Reduce Credentialism and Gender Discrimination in Education?

    Science.gov (United States)

    Lin, Ching-Yuan; Lin, Chun-Hung A.

    2012-01-01

    This paper investigates the effects of higher education expansion on the phenomena of credentialism and gender discrimination in education. Using the survey data of Family Income and Expenditure by DGBAS, Taiwan from 1980 to 2009, we examine the time path of the effect of higher education expansion on household expenditures for children's…

  1. Best Practices of Online Education: A Guide for Christian Higher Education

    Science.gov (United States)

    Maddix, Mark A., Ed.; Estep, James R., Ed.; Lowe, Mary E., Ed.

    2012-01-01

    The book provides best practices from online educators who are engaged in online teaching and program development in Christian higher education. It also explores the distinct aspects of teaching and developing online courses and programs from a Christian perspective and within Christian higher education institutions. As such it is can serve as a…

  2. Global Isomorphism and Governance Reform in Chinese Higher Education

    Science.gov (United States)

    Cai, Yuzhuo

    2010-01-01

    In the past three decades, higher education reforms have taken place almost everywhere in the world, and governance or the way that higher education is or should be coordinated has become a global topic. The governance reform in Chinese higher education emerged against such a background. The current studies on Chinese higher education reforms…

  3. Multimedia Usage among Islamic Education Lecturers at Higher Education Institution

    Science.gov (United States)

    Hamzah, Mohd Isa; Rinaldi; Razak, Khadijah Abdul

    2014-01-01

    This study aims to examine the level of multimedia usage among Islamic education lecturers at higher education institutions in West Sumatera, Indonesia. The participants were chosen from three types of higher institutions by using stratified random sampling. The data was collected from 250 students using questionnaires. The findings showed that…

  4. Quality Assurance for Higher Education Franchising.

    Science.gov (United States)

    Yorke, Mantz

    1993-01-01

    The practice of "franchising" higher education programs, or provision of educational programs through vendors, is examined as it occurs in the United Kingdom as a result of recent educational policy changes. A set of principles for assuring the quality of such programs is proposed. (MSE)

  5. Accreditation and Expansion in Danish Higher Education

    DEFF Research Database (Denmark)

    Rasmussen, Palle

    2014-01-01

    During the last decade, an accreditation system for higher education has been introduced in Denmark. Accreditation partly represents continuity from an earlier evaluation system, but it is also part of a government policy to increasingly define higher education institutions as market actors....... The attempts of universities to increase their student enrolments have combined with the logic of accreditation to produce an increasing number of higher education degrees, often overlapping in content. Students’ scope for choice has been widened, but the basis for and the consequences of choice have become...

  6. IMPROVING MANAGEMENT INFORMATION SYSTEMS AT A HIGHER EDUCATIONAL INSTITUTION

    Directory of Open Access Journals (Sweden)

    Nataliya N. Fedyakova

    2016-06-01

    Full Text Available Introduction: this paper deals with the foreign and domestic experience of creation and use of educational institution management automation systems. The problems of higher educational institutions management are essential in conditions of growing competition between educational institutions. Their complexity and timeliness defines multifunctional activity of higher educational institutions, diversity of funding sources, the variety of forms and types of educational, scientific, industrial and economic activities, the need for monitoring of the market of educational services and the labor market (including the need for employment of graduates, the necessity for adaptation to continuously changing economic conditions. Materials and Methods: system approach and method of comparison were used in analysing the current state of development and organisation of the automated information systems of higher education. These methods were also used to compare the qualitative characteristics of different technologies and methods of creation of the automated information systems. Results: the foreign and domestic educational institution management automation systems SIMS. net, Capita Education, SPRUT, Galaxy of Higher Educational Institution Management”, and “GSVedomosty” were analysed. Disadvantages of the functional module AIS – AWP pertaining to the University Rector of the higher educational institution were found. The improvement of higher educational institution AIS by implementing decision support systems for the management, made on the basis of the model of SaaS (software as a service is discussed. The author developed a model of automated score-rating system to assess the individual performance of students. Discussion and Conclusions: the author tackles the problems of higher educational institution AIS taking into account the specifics of the use of higher educational institution management information systems. They have a practical

  7. Higher Education Quality Assessment Model: Towards Achieving Educational Quality Standard

    Science.gov (United States)

    Noaman, Amin Y.; Ragab, Abdul Hamid M.; Madbouly, Ayman I.; Khedra, Ahmed M.; Fayoumi, Ayman G.

    2017-01-01

    This paper presents a developed higher education quality assessment model (HEQAM) that can be applied for enhancement of university services. This is because there is no universal unified quality standard model that can be used to assess the quality criteria of higher education institutes. The analytical hierarchy process is used to identify the…

  8. E ‑learning in Higher Education

    Directory of Open Access Journals (Sweden)

    Dorota Górska

    2016-09-01

    Full Text Available The vast use of the Internet and the increasingly widespread access to the latest technologies have become the main reason for the development of remote teaching services. In an effort to modernize the educational offer, higher education institutions placed, in their programs of studies, different possibilities of teaching using „distance learning”. This trend is already very common in the world’s largest universities. The Polish higher education system, keeping the pace with current trends, has created a legal foundation for the use of modern forms of teaching. The current approach to teaching is also a response to the offer of leading universities of the world and thus the search for competitive advantage in the international educational market. The aim of the article is to present main objectives of the teaching method of e ‑learning, and at the same time, to present the legal status and the rules for the use of e ‑learning in Polish higher education. The article is based on the experience of such teaching introduced at the Pontifical University of John Paul II in Krakow.

  9. Globalisation and access to higher education

    NARCIS (Netherlands)

    van der Wende, Marijk

    2003-01-01

    This article addresses the growing demand for access to higher education and the conditions under which this is leading to a worldwide market. The supply of transnational (or cross-border) education and the export of educational services play an increasingly important role in fulfilling this demand.

  10. Web 2.0 in Dutch Higher Education

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2008). Web 2.0 in Dutch Higher Education. In J. Armstrong & T. Franklin (Eds.), A Review of Current and Developing International Practice in the Use of Social Networking (Web 2.0) in Higher Education (pp. 61-71). Bristol: Clex.

  11. The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

    Directory of Open Access Journals (Sweden)

    Taoyi Yang

    2017-11-01

    Full Text Available The alpha-7 nicotinic acetylcholine receptor (α7 nAChR, consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders. Enhancement of α7 nAChR function is considered to be a potential therapeutic strategy aiming at ameliorating cognitive deficits of neuropsychiatric disorders such as Alzheimer's disease (AD and schizophrenia. Currently, a number of α7 nAChR modulators have been reported and several of them have advanced into clinical trials. In this brief review, we outline recent progress made in understanding the role of the α7 nAChR in multiple neuropsychiatric disorders and the pharmacological effects of α7 nAChR modulators used in clinical trials.

  12. α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile-Duct Ligated Mice.

    Science.gov (United States)

    Ehrlich, Laurent; O'Brien, April; Hall, Chad; White, Tori; Chen, Lixian; Wu, Nan; Venter, Julie; Scrushy, Marinda; Mubarak, Muhammad; Meng, Fanyin; Dostal, David; Wu, Chaodong; Lairmore, Terry C; Alpini, Gianfranco; Glaser, Shannon

    2018-03-26

    α7-nAChR is a nicotinic acetylcholine receptor (specifically expressed on hepatic stellate cells, Kupffer cells, and cholangiocytes) that regulates inflammation and apoptosis in the liver. Thus, targeting α7-nAChR may be therapeutic in biliary diseases. Bile-duct ligation (BDL) was performed on wild-type (WT) and α7-nAChR-/- mice. We first evaluated the expression of α7-nAChR by immunohistochemistry (IHC) in liver sections. IHC was also performed to assess intrahepatic bile-duct mass (IBDM), and Sirius Red staining was performed to quantify the amount of collagen deposition. Immunofluorescence was performed to assess co-localization of α7-nAChR with bile ducts (co-stained with CK-19) and hepatic stellate cells (HSCs) (co-stained with desmin). The mRNA expression of α7-nAChR, Ki67/PCNA (proliferation), fibrosis genes (TGF-β1, Fibronectin-1, Col1α1, and α-SMA), and inflammatory markers (IL-6, IL-1β, and TNFα) was measured by real-time PCR. Biliary TGF-β1 and hepatic CD68 (Kupffer cell marker) expression was assessed using IHC. α7-nAChR immunoreactivity was observed in both bile ducts and HSCs and increased following BDL. α7-nAChR-/- BDL mice exhibited decreased: (i) bile duct mass, liver fibrosis, and inflammation; and (ii) immunoreactivity of TGF-1 as well as expression of fibrosis genes compared to WT BDL mice. α7-nAChR activation triggers biliary proliferation and liver fibrosis and may be a therapeutic target in managing extra-hepatic biliary obstruction.

  13. Does higher education reduce body weight?

    DEFF Research Database (Denmark)

    Greve, Jane; Weatherall, Cecilie Dohlmann

    The prevalence of obesity and overweight has increased in almost all Western countries in the past twenty to thirty years, with social disparities in many of these countries. This paper contributes to the literature on the relation between education and body weight by studying the effect of higher...... education on body weight according to subgroups of parental income background. To uncover the causal relationship between higher education and body weight, we use a reform of the Danish student grant scheme, which involved a grant increase of approximately 60% in 1988. When using this reform as instrumental...

  14. Taxonomy of Corruption in Higher Education

    Science.gov (United States)

    Rumyantseva, Nataliya L.

    2005-01-01

    This article explores the phenomenon of corruption that has become common in higher education in developing countries around the world. Cases of educational corruption include, among others, paying bribes for grades, buying diplomas, and admissions to universities. An available body of literature on educational corruption does not provide…

  15. Advert for higher education

    OpenAIRE

    N.V. Provozin; А.S. Teletov

    2011-01-01

    The article discusses the features advertising higher education institution. The analysis results of marketing research students for their choice of institutions and further study. Principles of the advertising campaign on three levels: the university, the faculty, the separate department.

  16. OSHA: Implications for Higher Education.

    Science.gov (United States)

    National Association of College and University Business Officers, Washington, DC.

    Presented in this document are several articles concerning recommendations about the Occupational Safety and Health Act of 1970 (OSHA) and its implications for higher education. It is time for an educated look at facilities and programs and the beginning of plans which, in the long run, will bring colleges and universities into compliance with…

  17. Toward Integral Higher Education Study Programs in the European Higher Education Area: A Programmatic and Strategic View

    Directory of Open Access Journals (Sweden)

    Markus Molz

    2009-12-01

    Full Text Available This essay somehow arbitrarily freezes my ongoing attempt to grasp thepresent situation and future possibilities of higher education courses, programs,institutions and initiatives that are inspired by integral and likeminded approaches. Thefocus in this essay is on the European Higher Education Area and its specifics, whereassome implicit or explicit comparisons with the USA are made. My reflections aretriggered by the recurrent observation that in Europe there seems to be i more demandthan offer of integrally oriented higher education programs, ii an imbalance betweenoverused but little successful and underused but potentially more promising strategies toimplement such programs, iii little or no learning from past failures, and iv little mutualawareness, communication and collaboration between different activists and initiatives inthis field.The context for this essay is i the current societal macroshift, ii the unfolding ofacademic level integral and likeminded research worldwide, and iii the large scalereform of the European Higher Education systems brought about by the Bologna process,its (false promises and the potential it nevertheless has for realizing examples of a moreintegral higher education. On this basis the consequences for attempts to overcome arelatively stagnant state of affairs in Europe are discussed. Given that; most past attemptsto implement programs inspired by an integral worldview have failed from the start, ordisappeared after a relatively short period, or are marginalised or becoming remainstreamed,this essay aims to devise a potentially more promising strategic corridorand describes the contours of the results that could be brought about when following adevelopmental trajectory within this corridor. This futurising exercise is inspired byprinciples shared by many integral and likeminded approaches, especially thereconsideration, integration and transcendence of premodern, modern and postmodernstructures and practices

  18. Differential Cytokine Changes in Patients with Myasthenia Gravis with Antibodies against AChR and MuSK.

    Directory of Open Access Journals (Sweden)

    Vuslat Yilmaz

    Full Text Available Neuromuscular transmission failure in myasthenia gravis (MG is most commonly elicited by autoantibodies (ab to the acetylcholine receptor or the muscle-specific kinase, constituting AChR-MG and MuSK-MG. It is controversial whether these MG subtypes arise through different T helper (Th 1, Th2 or Th17 polarized immune reactions and how these reactions are blunted by immunosuppression. To address these questions, plasma levels of cytokines related to various Th subtypes were determined in patients with AChR-MG, MuSK-MG and healthy controls (CON. Peripheral blood mononuclear cells (PBMC were activated in vitro by anti-CD3, and cytokines were quantified in supernatants. In purified blood CD4+ T cells, RNA of various cytokines, Th subtype specific transcription factors and the co-stimulatory molecule, CD40L, were quantified by qRT-PCR. Plasma levels of Th1, Th2 and Th17 related cytokines were overall not significantly different between MG subtypes and CON. By contrast, in vitro stimulated PBMC from MuSK-MG but not AChR-MG patients showed significantly increased secretion of the Th1, Th17 and T follicular helper cell related cytokines, IFN-γ, IL-17A and IL-21. Stimulated expression of IL-4, IL-6, IL-10 and IL-13 was not significantly different. At the RNA level, expression of CD40L by CD4+ T cells was reduced in both AChR-MG and MuSK-MG patients while expression of Th subset related cytokines and transcription factors were normal. Immunosuppression treatment had two effects: First, it reduced levels of IL12p40 in the plasma of AChR-MG and MuSK-MG patients, leaving other cytokine levels unchanged; second, it reduced spontaneous secretion of IFN-γ and increased secretion of IL-6 and IL-10 by cultured PBMC from AChR-MG, but not MuSK-MG patients. We conclude that Th1 and Th17 immune reactions play a role in MuSK-MG. Immunosuppression attenuates the Th1 response in AChR-MG and MuSK-MG, but otherwise modulates immune responses in AChR-MG and Mu

  19. Quality assessment in higher education using the SERVQUALQ model

    Directory of Open Access Journals (Sweden)

    Sabina Đonlagić

    2015-01-01

    Full Text Available Economy in Bosnia and Herzegovina is striving towards growth and increased employment and it has been proven by empirical studies worldwide that higher education contributes to socio-economic development of a country. Universities are important for generation, preservation and dissemination of knowledge in order to contribute to socio-economic benefits of a country. Higher education institutions are being pressured to improve value for their activities and providing quality higher education service to students should be taken seriously. In this paper we will address the emerging demand for quality in higher education. Higher education institutions should assess quality of their services and establish methods for improving quality. Activities of quality assurance should be integrated into the management process at higher education institutions. This paper is addressing the issue of service quality measurement in higher education institutions. The most frequently used model in this context is the SERVQUAL model. This model is measuring quality from the students' point of view, since students are considered to be one of the most important stakeholders for a higher education institution. The main objective of this research is to provide empirical evidence that the adapted SERVQAL model can be used in higher education and to identify the service quality gap based on its application at one institution of higher education (Faculty of Economics in Bosnia and Herzegovina. Furthermore, results of the gap analysis using the SERVQUAL methodology provide relevant information in which areas improvement is necessary in order to enhance service quality.

  20. The Study of Second Higher Education through Mathematical Statistics

    Directory of Open Access Journals (Sweden)

    Olga V. Kremer

    2014-05-01

    Full Text Available The article deals with the statistic reasons, age and wages of people who get the second higher education. People opt for the second higher education mostly due to many economical and physiological factors. According to our research, the age is a key motivator for the second higher education. Based on statistical data the portrait of a second higher education student was drawn.

  1. The Marketing of Higher Education.

    Science.gov (United States)

    Brooker, George; Noble, Michael

    1985-01-01

    Formal college and university marketing programs are challenging to develop and implement because of the complexity of the marketing mix, the perceived inappropriateness of a traditional marketing officer, the number of diverse groups with input, the uniqueness of higher education institutions, and the difficulty in identifying higher education…

  2. Stakeholder Analisys of Higher Education Institutions

    Directory of Open Access Journals (Sweden)

    Ivana Maric

    2013-04-01

    Full Text Available In recent years, knowledge, the human capital, and learning organizations have become the key determinants of current global progress. Higher educational sector has been faced with globalization and strong competition. Therefore, the need has arisen for professional management structures and more entrepreneurial style of leadership. Organizations have been transformed to learning organizations by the life long learning concept, while the knowledge management has become the leading tool in building competitive advantages. High education organizations are being pushed forward by competitiveness. That pressure requires continuous improvement emphasizing the need for measuring outcomes and building excellence. The paradigm of stakeholder analysis, applied to specific determinations of the system of higher education institutions, could be a good way for comprehending and predicting interests, needs and requirements of all key players in the environment. The purpose of this paper is to enhance the possibility of understanding the connection between higher education institutions and its environment in context of stakeholder analysis. The paper uses literature as a basis in identifying critical parameters for stakeholder analysis and its implementation to higher education sector. The findings of the paper reveal that the concept of stakeholders is critical and difficult to implement everywhere and to everything. There is a clear attempt of all organizations, especially those that create and encourage knowledge, to understand the actions of all participants and predictions of interests and requirements of the changing environment.

  3. South African Journal of Higher Education: Contact

    African Journals Online (AJOL)

    Principal Contact. Prof Yusef Waghid Editor-in-Chief South African Journal of Higher Educatio. South African Journal of Higher Education Faculty of Education Stellenbosch University. Private Bag X1 Matieland 7602. Phone: +27 (021) 8082419. Fax: +27 (021) 8082283. Email: yw@sun.ac.za ...

  4. Education and Social Cohesion: Higher Education

    Science.gov (United States)

    Moiseyenko, Olena

    2005-01-01

    Social cohesion is understood as the social networks and the norms of reciprocity and trustworthiness that arise from connections among individuals. When students attend higher education institutions, they go through a process of socialization, and it is vital to ensure that they acquire the core values that underpin the social cohesion. This…

  5. Academic Freedom in Higher Education

    Directory of Open Access Journals (Sweden)

    Tokay GEDİKOĞLU

    2013-12-01

    Full Text Available In this study, the concept ‘academic freedom’ is discussed, its implications and value for the academics, institutions of higher education, and the society are focused, and a few suggestions for the Turkish higher education are made. Academic freedom is defined as the freedom of the academic staff to look for and to find the truth in their scientific field, to publish the findings, and to teach these findings to their students without any external intervention. The concept has gained a further definition with inclusion of research activities into academic freedom as part of the reform attempts started in the German higher education in the 19th century. Therefore, academic freedom is at the very core of the missions of the institutions of higher education; that is, teaching-learning and research. On the point of academic staff and their academic activities of the academic freedom, the subjects such as the aim of the course, choosing the teaching materials and textbooks, the lecturer, and the criteria for the measurement and evaluation of the course take place. And he point of research covers the aim of the study, academicians can’t be imposed the involve in an academic and artistic studies that conflict their values and beliefs; researchers should comply with codes of ethical principles and practices during the process of researching; and research outputs should be reported accurately and honestly without any misleading manipulation. Academic freedom does not provide any exemption from accountability in academic activities of the faculty, nor does it provide any right to act against the well-being of the society, current laws and regulations, and codes of ethical principles and practices.

  6. Models for mergers in higher education

    African Journals Online (AJOL)

    Investing in creativity: Many happy returns. Education Leadership, ... A possible model for higher education mergers, based on such extrapolation, is ..... working styles should be carefully managed from the very beginning of the process.

  7. Disability Studies in Higher Education

    Science.gov (United States)

    Taylor, Steven J.

    2011-01-01

    As a topic of study, disability is not new at institutions of higher education. Psychological and intellectual disabilities have been of interest in psychiatry and psychology at least since the late 1800s and early 1900s. The post-World War II era, in particular, witnessed the rapid expansion of academic programs in special education, vocational…

  8. Trends In Funding Higher Education In Romania And EU

    Directory of Open Access Journals (Sweden)

    Raluca Mariana Dragoescu

    2014-05-01

    Full Text Available Education is one of the determinants of the economic growth in any state, education funding representing thus a very important aspect in public policies. In this article we present the general principles of funding higher education in Romania and how it evolved over the last decade, stressing that the public higher education has been consistently underfunded. We also present an overview of the evolution of the main statistical indicators that characterize higher education in Romania, the number of universities and faculties, the number of students, number of teachers, revealing discrepancies between their evolution and the evolution of funding. We compared the funding of higher education in Romania and EU countries highlighting the fact that Romania should pay a special attention to higher education to achieve the performancen of other EU member countries.

  9. Transcultural Interaction and Linguistic Diversity in Higher Education

    DEFF Research Database (Denmark)

    This volume presents the current state of the art for research on the sociolinguistic consequences of the internationalization of higher education for university students. Its focus on “the student experience” for an increasingly mobile university student population is intended to foreground...... this particular area as a counterfoil to pedagogical studies of, for example, teaching or research practice in international(izing) university education, or work which concentrates on higher education policies at governmental levels. International Higher Education has emerged strongly in recent years as an area...

  10. Reciprocal activation of α5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation.

    Science.gov (United States)

    Zhang, Yao; Jia, Yanfei; Li, Ping; Li, Huanjie; Xiao, Dongjie; Wang, Yunshan; Ma, Xiaoli

    2017-07-20

    Cigarette smoking is the top environmental risk factor for lung cancer. Nicotine, the addictive component of cigarettes, induces lung cancer cell proliferation, invasion and migration via the activation of nicotinic acetylcholine receptors (nAChRs). Genome-wide association studies (GWAS) show that CHRNA5 gene encoding α5-nAChR is especially relevant to lung cancer. However, the mechanism of this subunit in lung cancer is not clear. In the present study, we demonstrate that the expression of α5-nAChR is correlated with phosphorylated STAT3 (pSTAT3) expression, smoking history and lower survival of non-small cell lung cancer (NSCLC) samples. Nicotine increased the levels of α5-nAChR mRNA and protein in NSCLC cell lines and activated the JAK2/STAT3 signaling cascade. Nicotine-induced activation of JAK2/STAT3 signaling was inhibited by the silencing of α5-nAChR. Characterization of the CHRNA5 promoter revealed four STAT3-response elements. ChIP assays confirmed that the CHRNA5 promoter contains STAT3 binding sites. By silencing STAT3 expression, nicotine-induced upregulation of α5-nAChR was suppressed. Downregulation of α5-nAChR and/or STAT3 expression inhibited nicotine-induced lung cancer cell proliferation. These results suggest that there is a feedback loop between α5-nAChR and STAT3 that contributes to the nicotine-induced tumor cell proliferation, which indicates that α5-nAChR is an important therapeutic target involved in tobacco-associated lung carcinogenesis. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

  11. Funding medical education: should we follow a different model to general higher education?

    Directory of Open Access Journals (Sweden)

    Kieran Walsh

    2015-09-01

    Full Text Available ISSUE. There has been much recent discussion on the funding of medical education. There has also been much discussion about the funding of higher education more generally. EVIDENCE. The topics of discussion have included the rising costs of education; who should pay; the various potential models of funding; and how best to ensure maximum returns from investment. IMPLICATIONS. Medical education has largely followed the emerging models of funding for higher education. However there are important reasons why the funding models for higher education may not suit medical education. These reasons include the fact that medical education is as important to the public as it is to the learner; the range of funding sources available to medical schools; the strict regulation of medical education; and the fact that the privatisation and commercialisation of higher education may not been in keeping with the social goals of medical schools and the agenda of diversification within the medical student population.

  12. Gore's Controversial Priorities for Higher Education.

    Science.gov (United States)

    Gose, Ben

    2000-01-01

    Evaluates presidential candidate Al Gore's priorities for higher education, noting criticism by some educators of his emphasis on benefits for the middle class and the large number of specific proposals he has offered, including the College Opportunity Tax Cut, 21st Century Teachers' Corps, 401(j) Educational Savings Accounts, the National Tuition…

  13. The Australopithecus Afarensis (Lucy) of Higher Education.

    Science.gov (United States)

    Gamble, John King

    1999-01-01

    Uses a fictitious character and story to express doubts about the use of business and marketing principles in American higher education. Asserts that higher education is profoundly different from other institutions, and that colleges and universities should be shielded from the vagaries of the market. (CAK)

  14. Mapping Global Research on International Higher Education

    Science.gov (United States)

    Kuzhabekova, Aliya; Hendel, Darwin D.; Chapman, David W.

    2015-01-01

    The purpose of the study is to map global research in international higher education. Specifically, the study uses bibliometric and social network analysis methods to identify key individuals, institutions, countries, and disciplines contributing to research in international higher education and to investigate patterns of connectivity among…

  15. Workforce Development, Higher Education and Productive Systems

    Science.gov (United States)

    Hordern, Jim

    2014-01-01

    Workforce development partnerships between higher education institutions and employers involve distinctive social and technical dynamics that differ from dominant higher education practices in the UK. The New Labour government encouraged such partnerships in England, including through the use of funding that aimed to stimulate reform to…

  16. Managerialism and higher education governance: Implications for ...

    African Journals Online (AJOL)

    This article identifies some of the implications of corporate forms of higher education governance for the management of South African universities. It explores corporate higher educational governance with reference to institutional autonomy incorporating academic freedom. It is the contention of this article that the primary ...

  17. Brazil: Opportunity and Crisis in Higher Education.

    Science.gov (United States)

    Schwartzman, Simon

    1988-01-01

    The Brazilian system of higher education is discussed, including its evolution, the 1968 reform and its unintended consequences, and the recommendations of the 1985 presidential commission on higher education. Issues of interinstitutional diversity, institutional autonomy, and the influence of special interest groups on policy are addressed.…

  18. Does Education Lead to Higher Generalized Trust?

    DEFF Research Database (Denmark)

    Charron, Nicholas; Rothstein, Bo

    2016-01-01

    to ‘trust others'. We hypothesize that higher levels of education will lead to higher social trust in individuals, given that the context (country or regions within countries) in which they reside has a sufficiently impartial and non-corrupt institutional setting. However, the positive effect of education...

  19. Leading Change in Higher Education

    Science.gov (United States)

    McRoy, Ian; Gibbs, Paul

    2009-01-01

    This article considers the situation in the UK higher education system and investigates specifically the leadership practice in a cluster of UK institutions as they changed their status. The research goes further to advocate a form of contextualized leadership that is relevant to higher institutions under change. (Contains 1 figure.)

  20. PROBLEMS AND PROSPECTS OF FINANCING HIGHER EDUCATION INSTITUTIONS OF UKRAINE

    Directory of Open Access Journals (Sweden)

    O. Krasilnyk

    2015-03-01

    Full Text Available The paper considers the problems of financing higher education institutions and focuses on formation of estimates of higher education institutions in Ukraine. The study established that the public and municipal education institutions financed by estimate and budget, which is determined by the amount and directions of use funds for implementation of functions and achieving the goals. The estimate has 2 components: general and special fund. The paper describes the practice of using general and special funds of higher education institutions. The results present the features of financing public and private higher education institutions. Public higher education institutions acutely feel the lack of financial resources. Tuition fees at public higher education institutions are calculated according to the requirements of the budget legislation. The conclusions suggest the prospects of financing higher education institutions in Ukraine. Higher education institutions need to give special attention to financial planning, optimization of financing sources and expenditures. It is necessary to reform the models, methods and forms of financing higher education sector.

  1. ADULT LEARNERS IN DISTANCE HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    NORICA-FELICIA BUCUR

    2012-05-01

    Full Text Available This paper attempts at identifying the main features that characterize distance higher education and adult education, respectively, in order to be able to establish to what extent adult learners can fit in distance higher education programs. The historical background of distance learning education, the factors that influence adult learners, and distance learning’s key objectives, effects, issues, advantages, and disadvantages are to be briefly investigated in order to reach the purpose of this paper. Recent developments in Information Technology have led to a new approach to teaching and learning, especially as far as adult learning and distance learning are concerned. Thus, this study will also focus on the consequences of using technology for course design, delivery, and the perception of adult learners participating in distance learning.

  2. Gas Chromatography, GC/Mass Analysis and Bioactivity of Essential Oil from Aerial Parts of Ferulago trifida: Antimicrobial, Antioxidant, AChE Inhibitory, General Toxicity, MTT Assay and Larvicidal Activities.

    Science.gov (United States)

    Tavakoli, Saeed; Vatandoost, Hassan; Zeidabadinezhad, Reza; Hajiaghaee, Reza; Hadjiakhoondi, Abbas; Abai, Mohammad Reza; Yassa, Narguess

    2017-09-01

    We aimed to investigate different biological properties of aerial parts essential oil of Ferulago trifida Boiss and larvicidal activity of its volatile oils from all parts of plant. Essential oil was prepared by steam distillation and analyzed by Gas chromatography and GC/Mass. Antioxidant, antimicrobial, cytotoxic effects and AChE inhibitory of the oil were investigated using DPPH, disk diffusion method, MTT assay and Ellman methods. Larvicidal activity of F. trifida essential oil against malaria vector Anopheles stephensi was carried out according to the method described by WHO. In GC and GC/MS analysis, 58 compounds were identified in the aerial parts essential oil, of which E-verbenol (9.66%), isobutyl acetate (25.73%) and E-β-caryophyllene (8.68%) were main compounds. The oil showed (IC 50 = 111.2μg/ml) in DPPH and IC 50 = 21.5 mg/ml in the investigation of AChE inhibitory. Furthermore, the oil demonstrated toxicity with (LD 50 = 1.1μg/ml) in brine shrimp lethality test and with (IC 50 = 22.0, 25.0 and 42.55 μg/ml) on three cancerous cell lines (MCF-7, A-549 and HT-29) respectively. LC 50 of stem, root, aerial parts, fruits, and flowers essential oils against larvae of An. stephensi were equal with 10.46, 22.27, 20.50, 31.93 and 79.87ppm respectively. In antimicrobial activities, essential oil was effective on all specimens except Escherichia coli , Aspergillus niger and Candida albicans. The essential oil showed moderate antioxidant activity, strong antimicrobial properties and good toxic effect in brine shrimp test and MTT assay on three cancerous cell lines.

  3. Money, Power, Equity and Higher Education

    Directory of Open Access Journals (Sweden)

    Seyed Ali Enjoo

    2018-03-01

    Full Text Available In current issue of the Journal of Medical Education, Afshar in the Editorial “The Role of Private Sector in Higher Education; From Quantity and Quality to Access and Social Justice” proposed the importance of justice and quality. (1 It seems that there are some differences between two typesof private sector in higher education. One type of private financial support in higher education comes purely from private sector without any contribution of public sector. The second type of private finance in the higher education especially the type which has grown recently in Iranianhigher education is a type of combination between public higher education and private sector the so called international branch of the university till recent years, and nowadays called selfgoverning campus of the university. (2 In this type of private contribution to public higher education those who have no or little money must pass very hard national examination to be accepted in the university, and those who can pay the tuition fee could enter to the best schools of that university without the exam (in the firstyear of the project or by loose standards or lower cut off scores. Actually, this is an instance of the double standards.One of the elements of being equitable and avoiding discrimination is to prevent undue achievement by the owners of the power such as owners of political, religious, economic, or military power, and to avoid any distinction according to race, colour, sex, language, and etc. (3 In this type ofprivate money absorption in the higher education, while the others have no extra way to enter to the university that would lead to achievement of scientific power, the owners of the economic powers’ daughters and sons could have a special chance to achieve scientific power by the powerof their parents, and there is a different criterion to enter the university based on non-scientific differences.In such situation growing student movements against

  4. Teaching strategies to elicit excellence in higher education

    NARCIS (Netherlands)

    Wolfensberger, Marca; van der Rijst, Roeland M.

    2011-01-01

    Pedagogy for gifted and talented students in higher education is the main topic of this study. Teachers of educational programmes designed for talented or highly motivated students in higher education (here called honours programmes) are challenged to stimulate students to increase the quality of

  5. Metacognition and Successful Learning Strategies in Higher Education

    Science.gov (United States)

    Railean, Elena, Ed.; Alev Elçi, Ed.; Elçi, Atilla, Ed.

    2017-01-01

    Metacognition plays an important role in numerous aspects of higher educational learning strategies. When properly integrated in the educational system, schools are better equipped to build more efficient and successful learning strategies for students in higher education. "Metacognition and Successful Learning Strategies in Higher…

  6. Applications of Data Mining in Higher Education

    OpenAIRE

    Monika Goyal; Rajan Vohra

    2012-01-01

    Data analysis plays an important role for decision support irrespective of type of industry like any manufacturing unit and educations system. There are many domains in which data mining techniques plays an important role. This paper proposes the use of data mining techniques to improve the efficiency of higher education institution. If data mining techniques such as clustering, decision tree and association are applied to higher education processes, it would help to improve students performa...

  7. Globalisation in higher education : manifestations and implications

    OpenAIRE

    LANZENDORF, Ute

    2013-01-01

    Globalisation has been adding a permanent new dimension to the world of higher education. So-called transnational or cross-border education is conceptualized here as a complement to the well-established internationalisation process. The paper elaborates on major aspects of globalisation in higher education, namely changes in the degree mobility of students, recent trends in the international mobility of scholars and also the increase in cross-border provision of study programmes (“programme m...

  8. Globalisation and Higher Education Development: A Critical Analysis

    Science.gov (United States)

    Yang, Rui

    2003-07-01

    This article sets out to analyse critically the nature of globalisation and how it is affecting higher education. The author first reviews the nature of globalisation, and then examines its international impact on higher education development. He contends that globalisation is predominantly economic, and points out that global exchanges in the economic, cultural and educational domains continue to be unequal. At the same time, education is increasingly treated as a business. By exposing the negative side of globalisation and its effects on universities, the author aims to counter the uncritical acceptance of globalisation as a positive force for higher education and society as a whole.

  9. Carelessness: A Hidden Doxa of Higher Education

    Science.gov (United States)

    Lynch, Kathleen

    2010-01-01

    This article explores the implications of new public sector "reforms" for the culture of higher education. It argues that a culture of carelessness, grounded in Cartesian rationalism, has been exacerbated by new managerialism. The article challenges a prevailing sociological assumption that the character of higher education culture is primarily…

  10. Changing the Narrative for Catholic Higher Education

    Science.gov (United States)

    Smith, Thomas W.

    2017-01-01

    Throughout the twentieth century, Catholic higher education in the United States modelled its institutional structures and intellectual life on the best standards and practices of the secular academy. The question for Catholic higher education became: How can we remain distinctively Catholic while engaging in these projects? Yet the situation…

  11. Selectivity and Openness in Israeli Higher Education.

    Science.gov (United States)

    Guri-Rozenblit, Sarah

    1990-01-01

    Israel's efforts to respond to growing social demands and to expand higher education are outlined, focusing on the extent of the state's involvement in higher education, demand and supply in Israeli universities, the social and academic functions of the Open University, and the overall academization of postsecondary institutions. (MSE)

  12. APPROACH TO QUALITY ASSURANCE IN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Zora Arsovski

    2007-03-01

    Full Text Available Quality assurance in higher education is streamed in two interconnected concepts: (1 quality management according to ISO 9000 and (2 Bologna process. In this paper both concepts are presented, with point on internal state and term plan activities for quality improvement in higher education in Serbia.

  13. Educational Reevaluation, Political Transformation: Québec and Higher Education

    Science.gov (United States)

    Unger, Zoe

    2013-01-01

    This paper considers the history of Québec's higher education system and the reforms that have contributed to the role of education in the province. Québec's education system has repeatedly been a site for social and political transformation; most recently, reevaluation of education's role in the province has revealed a tension between…

  14. The Business-Higher Education Link: Consider the Possibilities.

    Science.gov (United States)

    Hindle, Winston R., Jr.

    1993-01-01

    The Business Higher Education Forum, a group of corporate executives and college presidents, has been active in reform of elementary and secondary education by supporting collaborative efforts between business, higher education institutions, other sectors, and the schools. The guiding principle identified is that broad based alliances are…

  15. Determinants of Innovation Culture amongst Higher Education Students

    Science.gov (United States)

    Roffeei, Siti Hajar Mohd; Yusop, Farrah Dina; Kamarulzaman, Yusniza

    2018-01-01

    Globalisation has made many higher educational institutions reassess their educational contents and research activities in order to enhance innovation culture amongst students of higher education. Many universities now focus on research activities and research funding in raising their reputation and ranking which in turn will improve student…

  16. Dropout and completion in higher education in Europe: main report

    NARCIS (Netherlands)

    Vossensteyn, Johan J.; Kottmann, Andrea; Jongbloed, Benjamin W.A.; Kaiser, Franciscus; Cremonini, Leon; Stensaker, Bjorn; Hovdhaugen, Elisabeth; Wollscheid, Sabine

    2015-01-01

    Improving completion and reducing dropout in higher education are key concerns for higher education in Europe. This study on dropout and completion in higher education in Europe demonstrates that national governments and higher education institutions use three different study success objectives:

  17. Frontiers in Education at Japanese Institutes of Higher Education

    Science.gov (United States)

    Akiyama, Hidenori; Teramoto, Akemi; Shimomura, Naoyuki

    Education has become more and more important in Japanese institutes of higher education. Under such circumstances, societies of the study of frontiers in education have been held since the first society at September 20, 2002. The valuable 158 presentations have been carried out during 11 societies till March, 2006. These presentations are classified according to the topics of subjects. The topics are the improvement of education methods, IT aided education, cooperation with elementary school, junior high school, high school and companies, hands-on training (manufacturing), JABEE and others. Some distinct presentations are summarized.

  18. Current status of educational services in higher agricultural education in Ukraine

    Directory of Open Access Journals (Sweden)

    A. S. Cobets’

    2016-07-01

    Full Text Available Perspective directions of integration state policy of Ukraine Higher Education  into the European educational space and steps of implementation are determined. It is analysed the current state of higher agricultural education and integration current state policy of Ukraine Higher Education into the European educational space which allowed to identify problems and highlighted areas for further development. It is considered that it is necessary to establish cooperation in the triangle «production ­ education – science», extend the impact of scientists and experts on the content of  educational sector, come educational standards to needs and challenges of the real economy, as upgrades of industry standards for higher education, forming curricula, new teaching methods. Professionals training is possible only in a simulation of modern production principles, including the European Union. It is necessary to strengthen the position of agricultural universities as international educational and scientific centers in the framework of the European educational space. This refers to the practice and teaching students abroad, teachers training, participation in international programs, joint research. Ukrainian agricultural education system has competitive advantages despite the general neglect and can be considered unique in the educational market, it has conditions for the creation and testing of innovative products for different agro­climatic zones within a region. This provides the results of knowledge­based real conditions of agricultural production. Among the weaknesses of the education system it is possible to note a lack of cooperation with employers, lack of logistical and information and communication resources, mismatch of modern innovative designs and high technologies. It is therefore necessary to overcome the gap between the content of education and the real needs of innovation economy. In general, you need to ensure long­term practice

  19. Enterprise Education: A New Social Ethic for Higher Education?

    Science.gov (United States)

    Foreman-Peck, L.

    1993-01-01

    Review of a British initiative to develop entrepreneurship courses in higher education concludes that meeting industry demands can lead to conservative credentialism instead of enterprising qualities. Enterprise education should be concerned with present and future needs of employers, rather than their demands. (SK)

  20. Marketing activities of higher education institutions

    OpenAIRE

    Varađanin Vladimir

    2017-01-01

    Public sector marketing is a modern-day scientific discipline which is getting more and more attention. Institutions of higher education provide a specific kind of services to their users, which makes these institutions a part of the public sector. Due to dynamic changes in the environment, the demands and needs of higher education institution's users change, which makes it necessary to monitor these changes through certain marketing activities and adjust to them in order to satisfy the users...

  1. Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability.

    Science.gov (United States)

    Henderson, Brandon J; Wall, Teagan R; Henley, Beverley M; Kim, Charlene H; McKinney, Sheri; Lester, Henry A

    2017-11-01

    Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that are altered by nicotine, menthol, and acetylcholine. Dopaminergic (DA) neurons in the ventral tegmental area (VTA) mediate the positive reinforcing effects of nicotine. Using mouse models, we show that menthol enhances nicotine-induced changes in nicotinic acetylcholine receptors (nAChRs) expressed on midbrain DA neurons. Menthol plus nicotine upregulates nAChR number and function on midbrain DA neurons more than nicotine alone. Menthol also enhances nicotine-induced changes in DA neuron excitability. In a conditioned place preference (CPP) assay, we observed that menthol plus nicotine produces greater reward-related behavior than nicotine alone. Our results connect changes in midbrain DA neurons to menthol-induced enhancements of nicotine reward-related behavior and may help explain how smokers of menthol cigarettes exhibit reduced cessation rates.

  2. The Role of Outdoor Adventure Education in Facilitating Groupwork in Higher Education

    Science.gov (United States)

    Cooley, Sam J.; Burns, Victoria E.; Cumming, Jennifer

    2015-01-01

    Groupwork is an increasingly popular method of learning in higher education and the ability to work effectively with others is important for academic success and employability. This systematic review investigated the use of outdoor adventure education (OAE) in facilitating the development of transferable groupwork skills in higher education. The…

  3. New Information Technologies in Higher Education. Studies on the Introduction of New Information Technologies in Higher Education in the Europe Region.

    Science.gov (United States)

    Calude, Cristian; And Others

    An overview of the current status of new information technologies (NIT) in teaching, training, research, and administration of higher education internationally includes 25 papers: "The Impact of NITS of Higher Education" (C. Calude and M. Malitza); "Educational Implications of Artificial Intelligence" (M.A. Boden); "On…

  4. "Even with Higher Education You Remain a Woman": A Gender Perspective on Higher Education and Social Change in the Toliara Region of Madagascar

    Science.gov (United States)

    Skjortnes, Marianne; Zachariassen, Heidi Holt

    2010-01-01

    This article investigates some issues related to gender and education based on a qualitative, empirical study of women in higher education in the Toliara region of Madagascar. The focus is on how women's participation in higher education has created changes in gender relations, and how these women have succeeded in achieving higher education. In…

  5. Assessing Higher Education Learning Outcomes in Brazil

    Science.gov (United States)

    Pedrosa, Renato H. L.; Amaral, Eliana; Knobel, Marcelo

    2013-01-01

    Brazil has developed an encompassing system for quality assessment of higher education, the National System of Higher Education Evaluation (SINAES), which includes a test for assessing learning outcomes at the undergraduate level, the National Exam of Student Performance (ENADE). The present system has been running since 2004, and also serves as…

  6. Translanguaging in Higher Education: Beyond Monolingual Ideologies

    Science.gov (United States)

    Mazak, Catherine M., Ed.; Carroll, Kevin S., Ed.

    2016-01-01

    This book examines translanguaging in higher education and provides clear examples of what translanguaging looks like in practice in particular contexts around the world. While higher education has historically been seen as a monolingual space, the case studies from the international contexts included in this collection show us that institutions…

  7. Tennessee Higher Education Fact Book: 2015-2016

    Science.gov (United States)

    Tennessee Higher Education Commission, 2016

    2016-01-01

    In January 2010, the General Assembly passed the Complete College Tennessee Act (CCTA), a comprehensive reform agenda that seeks to transform public higher education through changes in academic, fiscal and administrative policies at the state and institutional level. While the higher education landscape has been shaped by the CCTA, higher…

  8. Higher education reform: getting the incentives right

    NARCIS (Netherlands)

    Canton, Erik; Venniker, Richard; Jongbloed, Benjamin W.A.; Koelman, Jos; Koelman, Jos; van der Meer, Peter; van der Meer, Peter; Vossensteyn, Johan J.

    2001-01-01

    This study is a joint effort by the Netherlands Bureau for Economic Policy Analysis (CPB) and the Center for Higher Education Policy Studies. It analyses a number of `best practices¿ where the design of financial incentives working on the system level of higher education is concerned. In Chapter 1,

  9. Day-by-Day: Higher Education in Afghanistan

    Science.gov (United States)

    Roof, David J.

    2015-01-01

    This paper examines higher education in Afghanistan. Based on qualitative research, including interviews with key policymakers and stakeholders, the paper examines the primary issues, challenges, progress, and future vision for higher education in the country. The research reveals that one of the most significant issues in the country in the…

  10. Apropos of the Quality Management in Higher Education

    Directory of Open Access Journals (Sweden)

    A. G. Kislov

    2012-01-01

    Full Text Available The paper is devoted to introduction and implementation of quality management system in the sphere of Russian higher education. The research demanded the prehistory observation of the above processes, their legal bases analysis, as well as setting the existing practices of the state control and supervision of education in compliance with the principles of TQM (Total Quality Management. Different normative acts and documents have been reviewed concerning accreditation of higher educational establishments, and determining the state policy of quality improvement of the higher school functioning. The author emphasizes that participation of different organizations - including educational ones – in certification procedures and competitions in the quality sphere is considered voluntary according to the Russian legislation. However, for getting the state accreditation educational establishments have no other way apart from setting the internal structures responsible for students training quality. The above structures in educational establishments look rather strange and alien duplicating in their best the state control and supervision system. They appear to be quite expansive for educational establishments and demanding extra time and effort from the staff. In conclusion the author points out that the state policy forcing the quality management issues reflects the interests of certain social groups, namely those who directly participate in external supervision of higher educa- tional institutions. The research findings can be applied while correcting the educational policy of the Russian Federation, and developing the concepts of regulatory legal acts in the higher educational sphere.

  11. Ranking Quality in Higher Education: Guiding or Misleading?

    Science.gov (United States)

    Bergseth, Brita; Petocz, Peter; Abrandt Dahlgren, Madeleine

    2014-01-01

    The study examines two different models of measuring, assessing and ranking quality in higher education. Do different systems of quality assessment lead to equivalent conclusions about the quality of education? This comparative study is based on the rankings of 24 Swedish higher education institutions. Two ranking actors have independently…

  12. Specifics of marketing in the higher education system

    OpenAIRE

    Motekaitienė, Aistė; Juščius, Vytautas

    2008-01-01

    The paper presents evaluation the possibilities and effectiveness of applying marketing principles in a higher education context. By comparing business and higher education marketing we can draw one clear conclusion: in both sectors the marketing processes can only be evaluated according to how successfully consumer needs are perceived and fullfilled with the help ofthe marketing mix. Higher educational institutions must develop a different marketing mix so they could satisfy the different ne...

  13. Higher Education Institutional and Program Evaluations in Taiwan and the Emerging Roles of Higher Education Evaluation and Accreditation Council of Taiwan (HEEACT)

    Science.gov (United States)

    Lee, Lung-Sheng; Wei, Yen-Shun; Wang, Li-Yun

    2013-01-01

    Post-secondary education institutions in Taiwan are divided into two tracks, general higher education (HE) and technological and vocational education (TVE). The evaluation of all universities/colleges is mandated by the University Act. Higher education institutions receive mandated institutional evaluation every six years and program evaluation…

  14. Glass Ceiling for Women in Higher Education.

    Science.gov (United States)

    Schedler, Petra; Glastra, Folke; Hake, Barry

    2003-01-01

    Discusses the place of women in higher education in the Netherlands. Suggests that it is not a question of numbers but of orientation, field, and the glass ceiling. Asserts that despite some improvement, higher education may be one of the last bastions against the recognition of women's worth. (Contains 42 references.) (JOW)

  15. 2015 Fact Book: Arkansas Public Higher Education

    Science.gov (United States)

    Arkansas Department of Higher Education, 2015

    2015-01-01

    This publication provides governmental and higher education decision-makers a statewide perspective of Arkansas public higher education finance for the 2015-17 biennium, as well as trends for the past several years. It also contains a detailed financial profile of each institution and presents a basis for comparative assessments of revenue sources…

  16. State Spending on Higher Education Capital Outlays

    Science.gov (United States)

    Delaney, Jennifer A.; Doyle, William R.

    2014-01-01

    This paper explores the role that state spending on higher education capital outlays plays in state budgets by considering the functional form of the relationship between state spending on higher education capital outlays and four types of state expenditures. Three possible functional forms are tested: a linear model, a quadratic model, and the…

  17. Redesigning Higher Education: Embracing a New Paradigm

    Science.gov (United States)

    Watson, William R.; Watson, Sunnie Lee

    2014-01-01

    Higher education is under enormous pressure to transform itself and embrace a new paradigm. Operating under an outdated model that no longer aligns with the realities of modern society, institutions of higher education are recognizing the need to drastically remake themselves or possibly cease to exist. This article explores the current landscape…

  18. Peer Learning in Specialist Higher Music Education

    Science.gov (United States)

    Hanken, Ingrid Maria

    2016-01-01

    Research on peer learning in higher education indicates that learning from and together with peers can benefit students in a number of ways. Within higher music education in Western, classical music, however, the master-apprentice tradition with its dominant one-to-one mode of tuition focuses predominantly on knowledge transmission from teacher to…

  19. Improvement of the public administration system of higher educational establishments

    Directory of Open Access Journals (Sweden)

    Andrei Vyacheslavovich Romin

    2015-10-01

    Full Text Available During research found that state regulation of higher education establishments activity is a special branch of the state, during which its authorities with the help of planning, organizing, monitoring is carried out the current regulation of the activities of higher education establishments, provide organization (integrationof the total interaction of students and teachers. Proposed to allocate the financial strategy of higher educational establishments as a major in strategic management of the higher education system. In this regard, it argued that the integration capacity of the university to the regional reproductive system will optimize government funding of higher educational establishments. Also, it helps to determine the main directions of further economic and financial development of the higher education system, prioritizing the development of already existing educational and training facilities in different regions of the state, the provision of appropriate state support for higher education establishments, which training necessary specialists for the state’s economy. The improvement the public administration system of a high school should be carried out through the formation of a coordination mechanism for higher education establishments. The introduction of this mechanism will provide an opportunity to identify the main activities of the higher education establishments adapt to the operating conditions of the region, based on the trends in the development of higher education, and to provide the basic needs of the labor market in the relevant specialists.

  20. Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice.

    Science.gov (United States)

    Somm, Emmanuel; Guérardel, Audrey; Maouche, Kamel; Toulotte, Audrey; Veyrat-Durebex, Christelle; Rohner-Jeanrenaud, Françoise; Maskos, Uwe; Hüppi, Petra S; Schwitzgebel, Valérie M

    2014-05-01

    Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated cation channels well characterized in neuronal signal transmission. Moreover, recent studies have revealed nAChR expression in nonneuronal cell types throughout the body, including tissues involved in metabolism. In the present study, we screen gene expression of nAChR subunits in pancreatic islets and adipose tissues. Mice pancreatic islets present predominant expression of α7 and β2 nAChR subunits but at a lower level than in central structures. Characterization of glucose and energy homeostasis in α7β2nAChR(-/-) mice revealed no major defect in insulin secretion and sensitivity but decreased glycemia apparently unrelated to gluconeogenesis or glycogenolysis. α7β2nAChR(-/-) mice presented an increase in lean and bone body mass and a decrease in fat storage with normal body weight. These observations were associated with elevated spontaneous physical activity in α7β2nAChR(-/-) mice, mainly due to elevation in fine vertical (rearing) activity while their horizontal (ambulatory) activity remained unchanged. In contrast to α7nAChR(-/-) mice presenting glucose intolerance and insulin resistance associated to excessive inflammation of adipose tissue, the present metabolic phenotyping of α7β2nAChR(-/-) mice revealed a metabolic improvement possibly linked to the increase in spontaneous physical activity related to central β2nAChR deficiency. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. The Role of Religion in Korean Higher Education

    Science.gov (United States)

    Lee, Jeong-Kyu

    2002-01-01

    This study examines the role of religion in Korean elite and higher education during the premodern and modern periods with descriptive analysis. The study focuses on the contribution of Buddhism and Confucianism to premodern elite education in Korea, particularly the interaction between Confucianism and Christianity with modern higher education in…

  2. Governance Arrangement in the Ethiopian Higher Education System ...

    African Journals Online (AJOL)

    Inspired by ideological shifts and pragmatic reasons, governments around the world are experimenting quasi-market type of higher education governance. Introduction of (quasi) market elements in higher education (HE) is also justified by its presumed benefits in efficiency among others. This study had Ethiopian higher ...

  3. New Mexico Higher Education Department Annual Report, 2016

    Science.gov (United States)

    New Mexico Higher Education Department, 2016

    2016-01-01

    The New Mexico Higher Education Department strives to bring leadership, guidance, and assistance to New Mexico's higher education stakeholders. The HED is committed to promoting best practices, institutional fiscal responsibility, and student achievement. Everything the agency does is through the lens of supporting New Mexico's higher education…

  4. Reinterpreting Higher Education Quality in Response to Policies of Mass Education: The Australian Experience

    Science.gov (United States)

    Pitman, Tim

    2014-01-01

    This article explores the relationship between mass education, higher education quality and policy development in Australia in the period 2008-2014, during which access to higher education was significantly increased. Over this time, which included a change of national government, the discursive relationship between mass higher education and…

  5. An empirical study on educational investment for all levels of higher education in China

    OpenAIRE

    YANG Juan; David MAYSTON

    2009-01-01

    With the expanding of higher education in China from 1999, more and more youngsters are able to invest in higher education, resulting a high unemployment rate for higher education graduates and more and more graduates employed in non-graduate position, while the analysis upon risk and return to each level of high education is absent due to the limitation of dataset. The paper employs college students sample survey to research the determinants of all levels of higher education beginning wages,...

  6. Road to the Future. General Aspects of Brazilian Higher Education and a Brief Comparison with Other Educational Modes. Yale Higher Education Research Group Working Paper.

    Science.gov (United States)

    Simao, Jose Veiga

    After a brief explanation of the economic and social background of Brazil, its educational system is described and the prospects for higher education there are explored. Like most nations, Brazil's higher education system is unique and adapted to its own needs. Its system bears similarities to both European and American traditions. In the near…

  7. Truly, Is Higher Education a Necessary Good or Evil? From the Perspective of Happiness Education

    Science.gov (United States)

    Lee, Jeong-Kyu

    2017-01-01

    The purpose of this paper is to discuss whether higher education is a necessary good or evil from the perspective of happiness education. To review the paper systematically, four research questions are addressed. First, what is the purpose of higher education? Second, is higher education a necessary good? Third, is higher education a necessary…

  8. Education of Music Teachers: A Study of the Brazilian Higher Education Programs

    Science.gov (United States)

    Mateiro, Teresa

    2011-01-01

    With reference to educational policies in the globalization process, the purpose of this article is to show the status of higher Music Teacher Education Programs in Brazil after the enactment of the "Directives and Bases Act No. 9.394", in 1996. This law emphasizes the evaluation process for higher education, including teaching quality…

  9. Culture Shock and Higher Education Performance: Implications for Teaching

    Science.gov (United States)

    Kelly, Philip; Moogan, Yvonne

    2012-01-01

    The globalisation of higher education brings together learners and teachers from differing systems, creating a heterogeneous and diverse environment. Yet many higher education institutions typically rely on foreign students themselves to adapt to their new higher education environments. An investigation was undertaken as to whether traditional…

  10. Institutional Traps of Russia’s Higher Education Nonlinear Development

    Directory of Open Access Journals (Sweden)

    Maria V.

    2018-03-01

    Full Text Available Introduction: the article deals with the problems arising in the Russian higher education system during its transformation. The topicality of this study lies in posing a problem of higher education development within the boundaries of a Russian macroregion. The objective of this article is to reveal barriers to the implementation of nonlinear processes in Russian higher education, which trigger the emergence of institutional traps and to determine the ways to avoid them. The purpose of this article is to identify barriers to the implementation of nonlinear processes in Russian higher education, which cause the emergence of institutional traps and determine the ways out of them. Materials and Methods: an institutional approach and the concept of non-linear models of higher education are the methodological basis of this research. The methods were developed by the research group of the Ural Federal University for sociological estimation of higher education transformation in the region. The procedure for selecting experts was realized according to the sociological methodology of I. E. Shteinberg (eight-window selection. Results: a summary analysis is made; inter-institutional interaction in terms of the “higher education – stakeholders” dyad is presented; the principal problematic areas are highlighted; and institutional traps preventing potential nonlinear development in Russian higher education are described. In the first problem zone, motivation traps, traps of formalisation/individualisation of the educational process, traps of intensification of the introduction of new information technologies in education and traps of unification of management were revealed. In the second problem area, traps of network interactions, traps of network interactions of higher education and employers, as well as traps of global/local orientation of universities were identified and analysed. Discussion and Conclusions: the authors outlined the most significant

  11. Massification to Marketization of Higher Education: Private University Education in Bangladesh

    Science.gov (United States)

    Ahmed, Jashim Uddin

    2016-01-01

    Massification of higher education is a contemporary phenomenon, and Bangladesh is an excellent example of massification in the sector. With increased alertness worldwide among nations, policy-makers and development bodies, massification of higher education is a requirement of time. Increasing number of youth also contribute to the phenomenon…

  12. Ecuador's higher education system in times of change

    OpenAIRE

    Van Hoof, Hubert B.; Estrella, Mateo; Eljuri, María Isabel; Torres León, Leonardo

    2013-01-01

    Ecuador’s higher education system is undergoing dramatic changes. The National Constitution of 2008 and the Higher Education Law of 2010 have changed the way Ecuador’s universities are funded, administered, and accredited. The importance of research was elevated and drastic changes were made to the academic qualifications and employment conditions of full-time faculty. This article describes the attempt to raise the level of Ecuador’s system of higher education and its impact on faculty and a...

  13. Ecuador's Higher Education System in Times of Change

    OpenAIRE

    Van Hoof, Hubert

    2013-01-01

    Ecuador’s higher education system is undergoing dramatic changes. The National Constitution of 2008 and the Higher Education Law of 2010 have changed the way Ecuador’s universities are funded, administered, and accredited. The importance of research was elevated and drastic changes were made to the academic qualifications and employment conditions of full-time faculty. This article describes the attempt to raise the level of Ecuador’s system of higher education and its impact on faculty and a...

  14. APPLYING MARKETING TO HIGHER EDUCATION: SCOPE AND LIMITS

    OpenAIRE

    Luminiţa NICOLESCU

    2009-01-01

    This paper focuses on applying marketing concepts to the higher education sector. It starts by shortly reviewing some of the main marketing concepts and continues with an overview of how such marketing concepts can be relevantly used for the higher education sector. The extent and limits in their application are identified and dicussed and the paper also suggests which of the marketing ideas are already highly used in higher education and which ones still have to be developed.

  15. Discipline and Theory in Higher Education Research

    Science.gov (United States)

    Tight, Malcolm

    2014-01-01

    Higher education research is, by its nature, rather an introspective field of study. It is also highly dispersed within and beyond the academy: inherently, therefore, it is a multidisciplinary field of study. An analysis of 567 articles published in 15 leading higher education journals in 2010 demonstrates both the breadth of interest in higher…

  16. Gratitude and Its Drivers within Higher Education

    Science.gov (United States)

    Cownie, Fiona

    2017-01-01

    This paper proposes that gratitude has a place in enabling us to understand students' experiences of higher education, and this has an implication for higher education (HE) marketing. This research examines the evidence for and focus of gratitude within the context of an undergraduate course with high levels of student satisfaction. It finds that…

  17. Stop Misusing Higher Education-Specific Price Indices

    Science.gov (United States)

    Gillen, Andrew; Robe, Jonathan

    2011-01-01

    In order to compare the price of things over time, it is necessary to use a price index to adjust for inflation. The Higher Education Price Index (HEPI) and the Higher Education Cost Adjustment (HECA) were designed to more accurately account for the spending patterns of colleges and universities. However, there are some methodological problems…

  18. Part-Time Higher Education: Employer Engagement under Threat?

    Science.gov (United States)

    Mason, Geoff

    2014-01-01

    Employer support for employees who are studying part-time for higher education qualifications constitutes a form of indirect employer engagement with higher education institutions that has contributed strongly to the development of work-related skills and knowledge over the years. However, this form of employer engagement with higher education…

  19. Improving Publication: Advice for Busy Higher Education Academics

    Science.gov (United States)

    Gibbs, Anita

    2016-01-01

    A major challenge for higher education academics is to research and publish when faced with substantial teaching responsibilities, higher student numbers, and higher output expectations. The focus of this piece is to encourage publication more generally by educators, and to build publication capacity, which academic developers can facilitate. The…

  20. Social influence and student choice of higher education institution

    Directory of Open Access Journals (Sweden)

    Joanna Krezel

    2017-09-01

    Full Text Available This conceptual paper discusses changes in higher education sector, growing competition as a result of new private education providers and the adoption of student-as-customer perspective in recruitment and marketing of higher education institutions. The paper reviews numerous models of student choice and identifies inconsistencies in the role of social factors in the student choice. These inconsistencies are of special importance in current higher education landscape and growing prominence of peer-to-peer communication via social media. Consequently, a thorough understanding of influences that effect student choice of higher education institution is imperative. This conceptual paper puts forward a conceptual framework that integrates Kelman’s processes of social influence and Cialdini-Goldstein’s goals that underpin the acceptance of that influence to examine the effects social context has on student choice of higher education institution.

  1. Liberty and Higher Education.

    Science.gov (United States)

    Thompson, Dennis F.

    1989-01-01

    John Stuart Mill's principle of liberty is discussed with the view that it needs to be revised to guide moral judgments in higher education. Three key elements need to be modified: the action that is constrained; the constraint on the action; and the agent whose action is constrained. (MLW)

  2. Conceptual approaches to international cooperation between higher education institutions

    Directory of Open Access Journals (Sweden)

    Tetiana Obolenska

    2016-12-01

    Full Text Available The existing conceptual and technological approaches to the organization and implementation of international cooperation between higher education institutions with the performance of international accreditation based on education quality system have been characterized in complex, considering the key trends of internationalization of higher education. Priority strategies of higher education internationalization and types of international academic cooperation between universities regarding education services were defined. It has been substantiated that the most important manifestation of higher education internationalization is international cooperation between universities regarding rendering education services, while the highest level of internationalization of this service is joint educational programs. A complex analysis of international accreditation requirements to joint education programs was made on the basis of the system of education quality improvement, its advantages were proven and its distinct features that influence the choice and substantiation of international cooperation, marketing and branding of individual programs were characterized. Technology of international accreditation for joint programs was detailed. Special attention was paid to the practical component of launching joint degree programs between Ukrainian and foreign higher education institutions. The experience of joint master’s degree programs of Kyiv National Economic University named after Vadym Hetman and the University of Redlands Business School (California, USA was analyzed.

  3. Comparative Case Studies on Indonesian Higher Education Rankings

    Science.gov (United States)

    Kurniasih, Nuning; Hasyim, C.; Wulandari, A.; Setiawan, M. I.; Ahmar, A. S.

    2018-01-01

    The quality of the higher education is the result of a continuous process. There are many indicators that can be used to assess the quality of a higher education. The existence of different indicators makes the different result of university rankings. This research aims to find variables that can connect ranking indicators that are used by Indonesian Ministry of Research, Technology, and Higher Education with indicators that are used by international rankings by taking two kind of ranking systems i.e. Webometrics and 4icu. This research uses qualitative research method with comparative case studies approach. The result of the research shows that to bridge the indicators that are used by Indonesian Ministry or Research, Technology, and Higher Education with web-based ranking system like Webometrics and 4icu so that the Indonesian higher education institutions need to open access towards either scientific or non-scientific that are publicly used into web-based environment. One of the strategies that can be used to improve the openness and access towards scientific work of a university is by involving in open science and collaboration.

  4. Geoinformation monitoring of the educational risk in educational institutions of higher education

    Directory of Open Access Journals (Sweden)

    Aleksandr N. Kolesenkov

    2017-01-01

    Full Text Available The effect, received by a person and society from mastering the basic professional educational programs is problematic to quantify, which leads to the emergence of a risk that characterizes the quality of management decision-making procedures for implementing the educational process in higher education institutions in terms of the level of achievement of the set criteria and indicators.The aim of the work is the development of technology for monitoring of the educational risk based on the geoinformation approach and methods of data mining. Assessment of the educational risk can be implemented through monitoring the quality of the implementation of the main professional educational programs of the institution.Monitoring of the educational risk in the implementation of the educational process in institutions of higher education means the collection, cataloging, pre-processing, analysis and visualization of the data, aimed at improving the efficiency and quality of providing educational services. To accomplish this goal, the following methods and approaches are used: geoinformation approach, cluster analysis, probability theory, data classification methods, forecasting methods, forecasting, and data visualization technologies.The scientific and methodological aspects of the development of the methodical, informational and instrumental support of the educational risk management system in educational institutions of higher education are examined. According to the results of the work, it is revealed that the use of geoinformation technologies increases the efficiency of management by the collection automation, processing and analysis of data on the implementation of educational programs.Modern geoinformation technologies provide the opportunity to create and integrate a system that has innovative analytical functionality, and implements new effective technologies, methods and algorithms in the tasks of monitoring the educational programs. The use of

  5. A Dynamic Systems Approach to Internationalization of Higher Education

    Science.gov (United States)

    Zhou, Jiangyuan

    2016-01-01

    Research shows that internationalization of higher education is a process rather than an end product. This paper applies the Dynamic Systems Theory to examine the nature and development of internationalization of higher education, and proposes that internationalization of higher education is a dynamic system. A dynamic framework of…

  6. Applying to Higher Education: Information Sources and Choice Factors

    Science.gov (United States)

    Simoes, Claudia; Soares, Ana Maria

    2010-01-01

    Higher education institutions are facing increasingly complex challenges, which demand a deeper understanding of the sources prospective students use when applying to a higher education institution. This research centres on students' decision-making process for higher education institutions, focusing on the pre-purchase period, and, in particular,…

  7. Gender Disparity and Its Impact on Higher Education | Deepika ...

    African Journals Online (AJOL)

    This paper “Gender Disparity and Its Impact on Higher Education” reviews a diverse literature on gender and higher education. Gender inequality is more pronounced in some aspects of the educational systems than in others. Explanations of gender inequality in higher education should distinguish between these different ...

  8. Just in Time Research: Data Breaches in Higher Education

    Science.gov (United States)

    Grama, Joanna

    2014-01-01

    This "Just in Time" research is in response to recent discussions on the EDUCAUSE Higher Education Information Security Council (HEISC) discussion list about data breaches in higher education. Using data from the Privacy Rights Clearinghouse, this research analyzes data breaches attributed to higher education. The results from this…

  9. Medical Education for Tennessee. A Report of the Tennessee Higher Education Commission.

    Science.gov (United States)

    Boone, Jerry N.; Woods, Myra S.

    This study of medical education was conducted as a part of the Tennessee Higher Education Commission's responsibility to design a master plan for higher education in Tennessee. It provides a background of information on Tennessee's needs for physicians and on the production of physicians by the three medical schools in the state. The study…

  10. Gas Chromatography, GC/Mass Analysis and Bioactivity of Essential Oil from Aerial Parts of Ferulago trifida: Antimicrobial, Antioxidant, AChE Inhibitory, General Toxicity, MTT assay and Larvicidal Activities

    Directory of Open Access Journals (Sweden)

    Saeed Tavakoli

    2017-10-01

    Full Text Available Background: We aimed to investigate different biological properties of aerial parts essential oil of Ferulago trifida Boiss and larvicidal activity of its volatile oils from all parts of plant.Methods: Essential oil was prepared by steam distillation and analyzed by Gas chromatography and GC/Mass. Anti­oxidant, antimicrobial, cytotoxic effects and AChE inhibitory of the oil were investigated using DPPH, disk diffusion method, MTT assay and Ellman methods. Larvicidal activity of F. trifida essential oil against malaria vector Anoph­eles stephensi was carried out according to the method described by WHO.Results: In GC and GC/MS analysis, 58 compounds were identified in the aerial parts essential oil, of which E-ver­benol (9.66%, isobutyl acetate (25.73% and E-β-caryophyllene (8.68% were main compounds. The oil showed (IC50= 111.2µg/ml in DPPH and IC50= 21.5 mg/ml in the investigation of AChE inhibitory. Furthermore, the oil demonstrated toxicity with (LD50= 1.1µg/ml in brine shrimp lethality test and with (IC50= 22.0, 25.0 and 42.55 µg/ml on three cancerous cell lines (MCF-7, A-549 and HT-29 respectively. LC50 of stem, root, aerial parts, fruits, and flowers essential oils against larvae of An. stephensi were equal with 10.46, 22.27, 20.50, 31.93 and 79.87ppm respectively. In antimicrobial activities, essential oil was effective on all specimens except Escherichia coli, Asper­gillus niger and Candida albicans.Conclusion: The essential oil showed moderate antioxidant activity, strong antimicrobial properties and good toxic effect in brine shrimp test and MTT assay on three cancerous cell lines.

  11. Status of Indian Women in Higher Education

    Science.gov (United States)

    Ghara, Tushar Kanti

    2016-01-01

    Women education and empowerment are the indicators of development. Women education ensures the holistic and long development. It includes equitable and increased access to technical and vocational education and training, higher education and research with due attention to quality assurance. This communication has taken a look on women…

  12. Mediatizing Higher Education Policies: Discourses about Quality Education in the Media

    Science.gov (United States)

    Cabalin, Cristian

    2015-01-01

    This article presents a critical-political discourse analysis of the media debate over quality assurance in higher education, which occurred in Chile after the 2011 student movement. Students criticized the privatization of higher education and the multiple flaws of this sector, which included corruption scandals during the process of quality…

  13. Reflections on Higher Education and the Media

    Science.gov (United States)

    Taylor, Barry

    2011-01-01

    In this article, the author argues that the relationship between higher education and the media changes continually and yet is, or should be, grounded in certain unchanging principles. He outlines some of the changes that have taken place over the past ten years in the relationship between higher education and the media; highlights the decline in…

  14. Reinventing Higher Education: The Promise of Innovation

    Science.gov (United States)

    Wildavsky, Ben, Ed.; Kelly, Andrew P., Ed.; Carey, Kevin, Ed.

    2011-01-01

    The inspiration for this timely book is the pressing need for fresh ideas and innovations in U.S. higher education. At the heart of the volume is the realization that higher education must evolve in fundamental ways if it is to respond to changing professional, economic, and technological circumstances, and if it is to successfully reach and…

  15. Higher Education and Happiness in the Age of Information

    Science.gov (United States)

    Lee, Jeong-Kyu

    2011-01-01

    This article discusses relations between happiness and higher education in the age of information, focusing on the need for the university to pursue happiness. Three questions are addressed. First, why should higher education pursue happiness? Second, what are the shapes and characteristics of higher education in the information age? Third, what…

  16. Quality Assurance: Strategic Choices for Higher Education in Turkey

    Directory of Open Access Journals (Sweden)

    Mahmut ÖZER

    2011-01-01

    Full Text Available As the number of students and higher education institutions in the world increases and there is a growing difficulty in financing the higher education systems, decision-makers have begun to show more interest in quality assurance. As quality assurance is given special attention in European countries, developing countries such as Turkey are interested in importing quality assurance systems. It is not possible to set quality assurance without sensitivity toward quality and without having quality as a cultural practice. The most likely encountered quality assurance approach in the world is that the higher education institution itself is responsible for its quality. In addition, external quality assurance procedures used are based on (academic peer review rather than on bureaucratic evaluations. Moreover, there is a lively debate across the world regarding the bureaucratic regulations of the quality assurance agencies and institutions that restrict the autonomy of higher education institutions. Without taking into consideration of the existing centralized structure of the higher education system in Turkey, of meeting social demands for the higher education, and of current higher education enrollment rates, the possible establishment of a quality assurance mechanism that may have sanctions on universities in Turkey is a threat to already limited autonomy of universities and is having a risk of additional bureaucratic burden. By laying out the roles and responsibilities of Turkish Council of Higher Education, the government and universities, this article discusses policies that should be adopted regarding the quality assurance.

  17. A conceptual framework for competence development in higher education

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    The paper presents a conceptual framework for competence development in management education, and higher education in general, which includes not only instrumental, but also practical, analytical and critical competencies. One consequence of the customization and marketization of higher education...... that competence development could and should be something more and something else than instrumental competence development. Based on a pragmatic reading of Batesons logical categories of learning, the paper develops a conceptual framework for competence development in higher education, which highlight...... contextually is blind, whereas contextual competence without instrumentality is empty. Based on a pragmatic reading and further development of Bateson´s logical categories of learning, the paper develops a conceptual framework for competence development in management education, and higher education in general...

  18. Institutions of Higher Education Pre-Service School Health Education Practices

    Science.gov (United States)

    Davidson, Brad; Telljohann, Susan K.; Dake, Joseph A.; Price, James H.

    2010-01-01

    Background: The quality of health education teachers is, in large part, dependent on the education they receive from their teacher preparation program. Purpose: This study assessed institutions of higher education (IHE) teaching practices in school health teacher preparation programs regarding the amount of time spent and content taught related to…

  19. Quantitative Analysis of the Adapted Physical Education Employment Market in Higher Education

    Science.gov (United States)

    Zhang, Jiabei

    2010-01-01

    The purpose of this study was to analyze the employment market of adapted physical education (APE) careers in higher education since 1975 to see if the increase of this market has continued since 1998. Based on the data collected from the "Chronicle of Higher Education", a total of 887 APE job openings have been posted since 1975,…

  20. Policies for Evaluation and Regulation of Higher Education in Brazil (1995-2010), Supporting the Expansion of Private Higher Education

    Science.gov (United States)

    Barreyro, Gladys Beatriz; Rothen, José Carlos; Santana, Andréia da Cunha Malheiros

    2014-01-01

    This paper analyzes the routes of the evaluation of higher education in Brazil, from 1995 until 2010. In 1995, during Fernando Henrique Cardoso's administration, higher education began a process of expansion through private enterprise. At that time, evaluation had a key role. The focus was the evaluation of courses conducted by the Ministry of…

  1. Closing the Gap: Opportunities for Distance Education to Benefit Adult Learners in Higher Education

    Science.gov (United States)

    Carlsen, A.; Holmberg, C.; Neghina, C.; Owusu-Boampong, A.

    2016-01-01

    Distance education in higher education is a fast-growing and widespread phenomenon. As many adults are unable to participate in on-campus education, distance education offers flexible learning paths that greatly enhance accessibility to higher education. Exploring distance education's potential to increase the participation of adult learners in…

  2. E-LEARNING INNOVATIONS IN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    NICOLETA GUDANESCU

    2012-05-01

    Full Text Available This scientific work is presenting the ways to do computer assisted education for students, giving the good practice examples, presenting new electronic learning systems, the advantages and limits and to try to emphasize that these days E-learning is one of the most efficient way to reach education at all levels, specially higher education systems. The objectives of this paper are: to explain the contribution of modern technologies and electronic systems to educational processes, to define the concept of technology based learning, to introduce the electronic tools for education, to present good practice examples in implementing E-learning systems in higher education and corporate environment in Romania and last but not least the new electronic learning systems. Introducing the computers and ITC in educational processes facilitates them and makes the educational system modern and efficient. E - learning innovations offers a core group of professional development courses designed to help anyone achieve professional advancement and personal enrichment. The programs are founded on an extensive experience and understanding of technology-based learning environments. They focus on the most current industry practices for various learning environments and best approaches for multiple learning styles. They ensure that the students get the information and skills needed to achieve more in teaching practice and to confidently enter the distance or online classroom.

  3. Higher Education Policy in Australia: Corporate or Coercive Federalism?

    Science.gov (United States)

    Smart, Don

    1991-01-01

    Although the Hawke government's general strategy of corporate federalism may dominate educational policy in Australia, higher education (excluding teacher education) is an exception. Because the Commonwealth assumed full financial responsibility for higher education, it has increasingly employed coercive federalism or simply ignored the states.…

  4. Framework for Entrepreneurship Education in Nigerian Higher ...

    African Journals Online (AJOL)

    ... aforementioned unending debates and unanswered questions; and advance the need for entrepreneurial education in Nigerian higher institutions of learning by reviewing and synthesizing available entrepreneurship education literature. The paper concludes that entrepreneurship education initiative is ideal for Nigeria, ...

  5. Higher Education: Open for Business

    Science.gov (United States)

    Gilde, Christian, Ed.

    2007-01-01

    This book addresses a problem in higher learning, which is newly recognized in the academic spotlight: the overcommercialization of higher education. The book asks that you, the reader, think about the following: Did you go to a Coke or Pepsi school? Do your children attend a Nike or Adidas school? Is the college in your town a Dell or Gateway…

  6. Higher Education: A Time for Triage?

    Science.gov (United States)

    Lagowski, J. J.

    1995-10-01

    Higher education faces unprecedented challenges. The confluence of changing economic and demographic tends; new patterns of federal and state spending; more explicit expectations by students and their families for affordable, accessible education; and heightened scrutiny by those who claim a legitimate interest in higher education is inescapably altering the environment in which this system operates. Higher education will never again be as it was before. Further, many believe that tinkering around the margins is no longer an adequate response to the new demands. Fundamental change is deemed necessary to meet the challenge of this melange of pressures. A number of commentators have observed that political and corporate America have responded to their challenges by instituting a fundamental restructuring of those institutions. The medical community is also in the midst of a similar basic restructuring of the health care delivery system in this country. Now its education's turn. People are questioning the historically expressed mission of higher education. They make the claim that we cost too much, spend carelessly, teach poorly, plan myopically, and when questioned, act defensively. Educational administrators, from department chairs up, are confronted with the task of simultaneously reforming and cutting back. They have no choice. They must establish politically sophisticated priority settings and effect a hard-nosed reallocation of resources in a social environment where competing public needs have equivalent--or stronger--emotional pulls. Triage in a medical context involves confronting an emergency in which the demand for attention far outstrips available assistance by establishing a sequence of care in which one key individual orchestrates the application of harsh priorities which have been designed to maximize the number of survivors. In recent years, the decisions that have been made in some centers of higher education bear a striking similarity. The literature

  7. Student Perceptions of Themselves as "Consumers" of Higher Education

    Science.gov (United States)

    Tomlinson, Michael

    2017-01-01

    This article first offers a survey of what has become an area of increasing interest in higher education: the rise of the so-called "student-consumer". This has been linked in part to the marketisation of higher education and the increased personal financial contributions individual students make towards their higher education. Drawing…

  8. Access to Higher Education in China: Differences in Opportunity

    Science.gov (United States)

    Wang, Houxiong

    2011-01-01

    Access to higher education in China has opened up significantly in the move towards a mass higher education system. However, aggregate growth does not necessarily imply fair or reasonable distribution of opportunity. In fact, the expansion of higher education has a rather more complex influence on opportunity when admissions statistics are viewed…

  9. THE PRICE OF HIGHER EDUCATION AND INDIVIDUAL DEMAND

    Directory of Open Access Journals (Sweden)

    Filiz Golpek

    2012-01-01

    Full Text Available The rise in the living standards in most of the world, the rise in population and schooling rates have increased the demand for higher education. The attribution of semi public property becomes determinant to decide whom will provide the supply and the production in semi public properties is realized by means of a supply and demand mechanism. The supply of higher education is mostly secured in accordance with the public demand as well as the resources available.  In addition, the fact that higher education services have produced significant benefits has led to over demand. This situation relates to a simple economic rule that a commodity or service which costs almost nothing or little will increase until the mariginal benefit of its demand equals to 0 or almost 0. However, the educational supply and demand is difficult to identify in accordance to the supply and demand and balance of price as observed in the economic theory. The high profits that would be attracted in the future are significant factors influencing individual’s decisions for investment. The decision for investment depends on the possible return in the future, the cost of investment, and the current interest rates. Higher education with investment purposes is influenced by these three factors and higher education is demanded more and more by individuals on the expectation that they will gain high profits In theory, it is accepted that the basic factors identifying the demand for higher education are in harmony with empirical research results in several countries including Turkey.

  10. Analogy, higher order thinking, and education.

    Science.gov (United States)

    Richland, Lindsey Engle; Simms, Nina

    2015-01-01

    Analogical reasoning, the ability to understand phenomena as systems of structured relationships that can be aligned, compared, and mapped together, plays a fundamental role in the technology rich, increasingly globalized educational climate of the 21st century. Flexible, conceptual thinking is prioritized in this view of education, and schools are emphasizing 'higher order thinking', rather than memorization of a cannon of key topics. The lack of a cognitively grounded definition for higher order thinking, however, has led to a field of research and practice with little coherence across domains or connection to the large body of cognitive science research on thinking. We review literature on analogy and disciplinary higher order thinking to propose that relational reasoning can be productively considered the cognitive underpinning of higher order thinking. We highlight the utility of this framework for developing insights into practice through a review of mathematics, science, and history educational contexts. In these disciplines, analogy is essential to developing expert-like disciplinary knowledge in which concepts are understood to be systems of relationships that can be connected and flexibly manipulated. At the same time, analogies in education require explicit support to ensure that learners notice the relevance of relational thinking, have adequate processing resources available to mentally hold and manipulate relations, and are able to recognize both the similarities and differences when drawing analogies between systems of relationships. © 2015 John Wiley & Sons, Ltd.

  11. The Hybridisation of Higher Education in Canada

    Directory of Open Access Journals (Sweden)

    Douglas Shale

    2002-01-01

    Full Text Available Canada's postsecondary institutions are becoming increasingly involved with technology enhanced learning, generally under the rubric of distance education. Growth and activity in distance education stems from rapid developments in communication and information technologies such as videoconferencing and the Internet. This case study focuses on the use of new technologies, primarily within the context of higher education institutions operating in Canada's English speaking provinces. Capitalising on the interactive capabilities of "new" learning technologies, some distance education providers are starting to behave more like conventional educational institutions in terms of forming study groups and student cohorts. Conversely, new telecommunications technologies are having a reverse impact on traditional classroom settings, and as a result conventional universities are beginning to establish administrative structures reflective of those used by distance education providers. When viewed in tandem, these trends reflect growing convergence between conventional and distance learning modes, leading to the hybridisation of higher education in Canada.

  12. Best Practices in Higher Education Faculty Motivation

    Science.gov (United States)

    McNamee, Lonnie

    2017-01-01

    There are many kinds of teachers in that teach in higher education. Some of these teachers teach at a high level while some teach at a substandard level. Educators are inspired and invigorated upon viewing students' achievement. Menlo and Low (1988) examined educator employment happiness throughout five countries and discovered that educators were…

  13. Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.

    Directory of Open Access Journals (Sweden)

    Irina Shelukhina

    Full Text Available Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs may shed light on their involvement in different physiological functions and diseases. Combination of site-directed mutagenesis and electrophysiology is a powerful tool to pinpoint the key amino-acid residues in the receptor ligand-binding site, but for α7 and α9 nAChRs it is complicated by their poor expression and fast desensitization. Here, we probed the ligand-binding properties of α7/α9 nAChR mutants by a proposed simple and fast calcium imaging method. The method is based on transient co-expression of α7/α9 nAChR mutants in neuroblastoma cells together with Ric-3 or NACHO chaperones and Case12 fluorescent calcium ion sensor followed by analysis of their pharmacology using a fluorescence microscope or a fluorometric imaging plate reader (FLIPR with a GFP filter set. The results obtained were confirmed by electrophysiology and by calcium imaging with the conventional calcium indicator Fluo-4. The affinities for acetylcholine and epibatidine were determined for human and rat α7 nAChRs, and for their mutants with homologous residues of α9 nAChR incorporated at positions 117-119, 184, 185, 187, and 189, which are anticipated to be involved in ligand binding. The strongest decrease in the affinity was observed for mutations at positions 187 and 119. The L119D mutation of α7 nAChR, showing a larger effect for epibatidine than for acetylcholine, may implicate this position in pharmacological differences between α7 and α9 nAChRs.

  14. An Analysis of Globalization and Higher Education in Malaysia

    Science.gov (United States)

    Arokiasamy, Anantha Raj A.

    2011-01-01

    This study aims to examine the impact of globalization on private higher education in Malaysia. The impact of globalization and the development of knowledge-based economy have caused much dramatic change to the character and functions of higher education in Malaysia. The major trend is the reforming and restructuring of private higher education in…

  15. DEVELOPMENT STRATEGY OF PARTNERSHIP OF HIGHER EDUCATION, SCIENCE AND BUSINESS

    Directory of Open Access Journals (Sweden)

    I. Mazur

    2014-12-01

    Full Text Available In the article the cooperation of higher education, science and business is analysed. A conflict of civilizations wave development in the confrontation of two forces: the "factory of Education" and force change is disclosed. European and Ukrainian higher education quality estimation is analysed. The effect of unsynchronization in time is educed between the necessities of business and possibilities of education and science. Reasons of bribery are exposed at higher school. The development strategy of partnership of higher education, science and business is proposed.

  16. Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Muhammad Yar

    2015-03-01

    Full Text Available Alzheimer's disease (AD is a fast growing neurodegenerative disorder of the central nervous system and anti-oxidants can be used to help suppress the oxidative stress caused by the free radicals that are responsible for AD. A series of selected synthetic indole derivatives were biologically evaluated to identify potent new antioxidants. Most of the evaluated compounds showed significant to modest antioxidant properties (IC50 value 399.07 140.0±50 µM. Density Functional Theory (DFT studies were carried out on the compounds and their corresponding free radicals. Differences in the energy of the parent compounds and their corresponding free radicals provided a good justification for the trend found in their IC50 values. In silico, docking of compounds into the proteins acetylcholinesterase (AChE and butyrylcholinesterase (BChE, which are well known for contributing in AD disease, was also performed to predict anti-AD potential.

  17. Higher Education Funding Formulas.

    Science.gov (United States)

    McKeown-Moak, Mary P.

    1999-01-01

    One of the most critical components of the college or university chief financial officer's job is budget planning, especially using formulas. A discussion of funding formulas looks at advantages, disadvantages, and types of formulas used by states in budgeting for higher education, and examines how chief financial officers can position the campus…

  18. Benchmarking for Higher Education.

    Science.gov (United States)

    Jackson, Norman, Ed.; Lund, Helen, Ed.

    The chapters in this collection explore the concept of benchmarking as it is being used and developed in higher education (HE). Case studies and reviews show how universities in the United Kingdom are using benchmarking to aid in self-regulation and self-improvement. The chapters are: (1) "Introduction to Benchmarking" (Norman Jackson…

  19. Evaluation in Higher Education

    Science.gov (United States)

    Bognar, Branko; Bungic, Maja

    2014-01-01

    One of the means of transforming classroom experience is by conducting action research with students. This paper reports about the action research with university students. It has been carried out within a semester of the course "Methods of Upbringing". Its goal has been to improve evaluation of higher education teaching. Different forms…

  20. Multimodal Landscaping in Higher Education Research

    DEFF Research Database (Denmark)

    Lueg, Klarissa

    2018-01-01

    The purpose of this paper is to introduce Multimodal Landscaping (ML) as a conceptual framework, and to illustrate how this approach can be applied within the field of higher education research. It is argued that ML is a suitable tool, especially, in studies investigating university...... internationalization, and in studies focusing on the agent level of higher education organizations. ML is argued to add to the diversity of methods within a social constructivist methodology. The author illustrates how ML is connected and/or different from kindred approaches. Pathways are proposed as to how...

  1. Innovative Directions of the Higher Education of Ukraine

    Directory of Open Access Journals (Sweden)

    Klyap Marianna

    2016-11-01

    Full Text Available The article clarifies the concept of “innovation”, including “educational innovation”, examines some innovative teaching methods in universities. The main approaches of implementation innovations in modern higher education of Ukraine are analysed. It also defines the differences between traditional and innovative teaching, discovers different variants of the classification of innovative teaching methods and formulates basic approaches to the selection of innovative didactic purpose in accordance with the classes, the advantages and disadvantages of the use of certain methods. It tightly describes actual interpretation of innovative study methods in the Ukrainian higher educational institutions, as well as the realization of the innovative aspects in the separate Ukrainian universities. The importance of innovation in the learning process of entering higher education of Ukraine into the European educational space is also being highlighted.

  2. Financial Resource Allocation in Higher Education

    Science.gov (United States)

    Ušpuriene, Ana; Sakalauskas, Leonidas; Dumskis, Valerijonas

    2017-01-01

    The paper considers a problem of financial resource allocation in a higher education institution. The basic financial management instruments and the multi-stage cost minimization model created are described involving financial instruments to constraints. Both societal and institutional factors that determine the costs of educating students are…

  3. 34 CFR 300.26 - Institution of higher education.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Institution of higher education. 300.26 Section 300.26 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

  4. Marketing services of higher education: theoretical aspect

    OpenAIRE

    Evgenyi Polonskyi

    2014-01-01

    The article is devoted to theoretical aspects of the use of marketing activities in institutions of higher education. The author analyzes of education from the standpoint of the marketing mix. The main factors of the external and internal environments affecting the educational institution.

  5. Knowledge Transfer in Romanian Higher Education

    Directory of Open Access Journals (Sweden)

    Mariana NICOLAE

    2013-05-01

    Full Text Available The purpose of this paper is to explore the process of knowledge transfer in Romanian Higher Education Organizations by focusing on aspects of leadership. The current economic and social contexts are under a process of transformation. Educational institutions make no exception, as they must adapt to the changing demands of the market if they want to survive. Concepts such as education massification, competitive advantage of universities, quality assurance, university performance are widely discussed nowadays. All in all, universities are knowlege organizations that are one of the key drivers of innovation, development, leadership and research, as they create and transfer knowledge. An organization’s ability to communicate, share and innovate is critical in order to meet the challenges of the knowledge society. Starting from this general background, the present paper explores the characteristics and behaviors necessary for an ellective leadership in Higher Education Organizations through a series of interviews with leaders in the academia.

  6. E-Policy and higher education: from formulation to implementation ...

    African Journals Online (AJOL)

    In so doing, I provide a basis for discourse about current international trends influencing e-policy in higher education. In conclusion an analysis of the government's (South Africa) e-policy and its impact on the e-policy of higher education is also provided. South African Journal of Higher Education Vol. 21 (6) 2008: pp. 643- ...

  7. Funding medical education: should we follow a different model to general higher education? Commentary.

    Science.gov (United States)

    Walsh, Kieran

    2015-01-01

    There has been much recent discussion on the funding of medical education. There has also been much discussion about the funding of higher education more generally. The topics of discussion have included the rising costs of education; who should pay; the various potential models of funding; and how best to ensure maximum returns from investment. Medical education has largely followed the emerging models of funding for higher education. However there are important reasons why the funding models for higher education may not suit medical education. These reasons include the fact that medical education is as important to the public as it is to the learner; the range of funding sources available to medical schools; the strict regulation of medical education; and the fact that the privatisation and commercialisation of higher education may not been in keeping with the social goals of medical schools and the agenda of diversification within the medical student population.

  8. Higher Education Students’ Behaviour to Adopt Mobile Learning

    Science.gov (United States)

    Batmetan, J. R.; Palilingan, V. R.

    2018-02-01

    Mobile phone is an electronic device most often used by Y generation in Indonesia. This ages have become an important part in the growth of higher education in this country. The problem raised in this study is that very few students in higher education are adopting and accessing digital learning content using mobile phones. The objective of this study is to investigate the higher education students’ behaviour in using mobile learning. The research method used is Structural equation models (SEM) method to analyse the factors that influence higher education students’ behaviour in using mobile learning. The results of this study indicate tends of this student 85% to keep internet access in privacy. The majority of respondent is 78% having behaviour to keep adopting mobile learning and still use it in the future. Why? because this study shows that on the level of usability, easy to use, easy to learn, in various devices have a significant effect on the level of adoption of mobile learning. Implication of this study is higher education students’ behaviour of especially Y generation tends to prioritize the usability towards mobile learning and will continue to adopt mobile learning in the future.

  9. Higher Education and the Professional Job Market

    Directory of Open Access Journals (Sweden)

    Alejandro Mungaray Lagarda

    2001-05-01

    Full Text Available The paper deals with the relationship between the professional job market and institutions of higher education, within the framework of socioeconomic globalization and regional decentralization processes. The discussion focuses on how this relationship generates flaws in the market due to the role played by higher education as an intermediary between job applicants and those offering employment and professional opportunities; and due also to the fact that higher education institutions have their own objectives, which differ from those of the market. The article states the need to acknowledge and overcome the limitations which the concentration of income imposes on Latin American students’ access to this educational level and their continuance in it. The paper also stresses the need for a closer connection between academic and job practices through curricular changes and the certification of knowledge that will be useful on the job. This would allow a better correlation with the productive sector, in that it would improve the absorption of graduates.

  10. The Soviet Higher Military Educational System

    Science.gov (United States)

    1982-02-01

    blems of management and administra- tion of higher educational institu- tions."’ Data on students alone in each institution totaled several... educational institutes with modern facilities and constantly perfecting their 35ibid., p. 58. Such "work" is classified as scientific research work...resources and train- ing support resources and be located both in the area of the permanent educational facility and in a training center

  11. AN INSTRUCTIONAL DESIGN MODEL FOR BLENDED HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    George Hack

    2016-07-01

    Full Text Available Instructional design models that are used by many higher education institutions to guide course design are insufficient for the unique opportunities of blended learning. Many established models are not practical tools for college faculty to use independently in the design of courses. Models like A.D.D.I.E., use a linear approach that can translate more easily into practical stages of course design, yet are historically rooted in the rapid prototyping of educational technologies or for designing military training and are inadequate for the complex demands of higher education, where learning outcomes are geared toward higher order thinking, scientific/clinical reasoning, and a syntheses of ideas into new knowledge. Presented here is an instructional design model that strategically incorporates the nuances of higher education, yet is practically framed to assist faculty with design challenges.

  12. The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

    Directory of Open Access Journals (Sweden)

    Urszula Baranowska

    2017-07-01

    Full Text Available α7-nACh is one of the major nicotinic cholinergic receptor subtypes found in the brain. It is broadly expressed in the hippocampal and cortical neurons, the regions which play a key role in memory formation. Although α7-nACh receptors may serve as postsynaptic receptors mediating classical neurotransmission, they usually function as presynaptic modulators responsible for the release of other neurotransmitters, such as glutamate, γ-aminobutyric acid, dopamine, and norepinephrine. They can, therefore, affect a wide array of neurobiological functions. In recent years, research has found that a large number of agonists and positive allosteric modulators of α7-nAChR induce beneficial effects on learning and memory. Consistently, mice deficient in chrna7 (the gene encoding α7-nAChR protein, are characterized by memory deficits. In addition, decreased expression and function of α7-nAChR is associated agoniwith many neurological diseases including schizophrenia, bipolar disorder, learning disability, attention deficit hyperactivity disorder, Alzheimer disease, autism, and epilepsy. In the recent years many animal experiments and clinical trials using α7-nAChR ligands were conducted. The results of these studies strongly indicate that agonists and positive allosteric modulators of α7-nAChR are promising therapeutic agents for diseases associated with cognitive deficits.

  13. Internationalising Indian Higher Education: Opportunities, Challenges and the Way Forward

    Directory of Open Access Journals (Sweden)

    Gautam Rajkhowa

    2017-06-01

    Full Text Available This paper examines the higher education system in India together with its status regarding internationalisation, and presents the case for the higher education sector in India to embrace internationalisation. Starting with an overview of the academic literature around the concepts of globalisation and internationalisation, and their interrelationship particularly in the context of higher education, the paper focuses on the specific issues of Indian higher education especially within the context of internationalisation. Reviewing the current landscape of the Indian higher education sector, the paper concludes that, in the context of a globally connected world, higher education in India is characterised by asymmetry in flows and unclear policies. Recommending that the internationalisation strategy focuses on the four strands of student and programme mobility; infrastructure and policy support; development of research capability; and the employment of technology as an enabler, the paper concludes that a clear approach to internationalisation would offer the potential to secure India a formidable global standing in higher education.

  14. Questioning the Role of Internationalization in the Nationalization of Higher Education: The Impact of the EU TEMPUS Programme on Higher Education in Syria

    Science.gov (United States)

    Ayoubi, Rami M.; Massoud, Hiba K.

    2011-01-01

    Given the need for major reform of the higher education programmes in Syria, and answering the voices that question the role of European Union (EU) in assisting the development of the higher education sector, this study presents an analysis of the contribution of (TEMPUS) Programme in modernising higher education in Syria. The study compares the…

  15. Creativity in Higher Education

    Science.gov (United States)

    Gaspar, Drazena; Mabic, Mirela

    2015-01-01

    The paper presents results of research related to perception of creativity in higher education made by the authors at the University of Mostar from Bosnia and Herzegovina. This research was based on a survey conducted among teachers and students at the University. The authors developed two types of questionnaires, one for teachers and the other…

  16. Towards Sustainable Internationalisation of Higher Education

    Science.gov (United States)

    Ilieva, Roumiana; Beck, Kumari; Waterstone, Bonnie

    2014-01-01

    This article engages with the question: what does the internationalisation of higher education in times of globalisation sustain and what should it sustain? We first consider, through literature on globalisation and Stier's ("Glob Soc Educ" 2(1):1-28, 2004) work, limitations of currently prevalent perspectives on…

  17. Geography and Values in Higher Education: 2

    Science.gov (United States)

    Huckle, John

    1978-01-01

    The geography curriculum in higher education reflects values held by the geographical and educational communities and by society in general. Teachers should transmit an environmental ethic by adopting relevant approaches from moral and political education. For journal availability, see SO 506 224. (Author/AV)

  18. A Bright Future for Russian Higher Education.

    Science.gov (United States)

    Kishkovsky, Sophia

    2000-01-01

    Russian higher education is reinventing itself, but in distinctly Russian ways. While universities embrace new technology, students are frustrated as new freedoms confront old educational methods (grueling entrance exams, rote learning, dictatorial professors, and minimal participation). Education is still basically Russian, though capitalism is…

  19. Higher Education as a Gift and as a Commons

    Directory of Open Access Journals (Sweden)

    Andreas Wittel

    2018-01-01

    Full Text Available This paper takes as a starting point Lewis Hyde’s (2007, xvi assertion that art is a gift and not a commodity: “Works of art exist simultaneously in two ‘economies’, a market economy and a gift economy. Only one of these is essential, however: a work of art can survive without a market, but where there is no gift there is no art.” I want to argue that the same claim should be made for those aspects of academic labour that refer to teaching and education. Education can survive without a market, but where there is no gift there is no education. However the gift that is part of all educational processes gets rather obscured in regimes where higher education is either a public good or a private good. In regimes of higher education as public good the gift gets obscured by the provision of a service by the state. In regimes of higher education as a private good (e.g. higher education in the UK the gift gets even more obscured, obviously so. It is only in a third educational regime, where education is a common good (e.g. the recent rise of the free universities, that the gift character of education can properly shine. Whilst this should be celebrated, the notion of a higher education commons poses some severe challenges. The paper ends with an examination of possibilities of academic activists to rescue or even strengthen the gift-like character of education.

  20. From elite to mass to universal higher education: from distance to open education

    Directory of Open Access Journals (Sweden)

    Larry Cooperman

    2014-01-01

    Full Text Available In 1970, Martin Trow, a professor at the University of California, Berkeley, identified a transition “underway in every advanced society, from elite to mass higher education and subsequently to universal access.” This article adapts this framework of the historical and structural development of higher education as a phased process in which absolute and relative growth of university enrollment transforms the institutions of higher education and alters its functions. The transition to universal access may support economic development, social mobility and greater income equality, in turn buttressing even the institution of democracy. Arriving at those optimal social outcomes is not automatic, however, because of a variety of remaining issues: how universality of higher education translates to economic growth and social equality. The problem of the ‘next 1%,’ shorthand for the continued entrance of new social layers into higher education presents novel challenges that ‘access’ alone may not solve.

  1. Developmental patterns of privatization in higher education

    DEFF Research Database (Denmark)

    Jamshidi, Laleh; Arasteh, Hamidreza; NavehEbrahim, Abdolrahim

    2012-01-01

    In most developing countries, as the young population increase in number and consequently, the demands for higher education rise, the governments cannot respond to all demands. Accordingly, they develop private higher education sectors as an alternative solution. In developed countries, some moving......: Indonesia, Malaysia, and Kenya. After a short outline of theoretical foundations, this study provides more in-depth explanations of the principal and common effective factors....

  2. Degrees of Integrity: The Threat of Corruption in Higher Education

    Science.gov (United States)

    Chapman, David W.; Lindner, Samira

    2016-01-01

    Corruption in higher education is the focus of growing international concern among governments, educators, students, and other stakeholders. Those working in higher education institutions now face a unique convergence of pressures that is creating a heightened threat to the integrity of the higher education enterprise worldwide. This paper draws…

  3. Technology Use in Higher Education Instruction

    Science.gov (United States)

    Elzarka, Sammy

    2012-01-01

    The significance of integrating technology use in higher education instruction is undeniable. The benefits include those related to access to instruction by underserved populations, adequately preparing students for future careers, capitalizing on best instructional practices, developing higher order thinking activities, and engaging students…

  4. Scientific collaboratories in higher education

    DEFF Research Database (Denmark)

    Sonnenwald, Diane H.; Li, Bin

    2003-01-01

    Scientific collaboratories hold the promise of providing students access to specialized scientific instruments, data and experts, enabling learning opportunities perhaps otherwise not available. However, evaluation of scientific collaboratories in higher education has lagged behind...

  5. Transcultural Interaction and Linguistic Diversity in Higher Education

    DEFF Research Database (Denmark)

    this particular area as a counterfoil to pedagogical studies of, for example, teaching or research practice in international(izing) university education, or work which concentrates on higher education policies at governmental levels. International Higher Education has emerged strongly in recent years as an area...... studies represent countries from across the globe: Australia, Austria, Canada, China (including Macau), Denmark, Germany, Iceland, Spain, UK, and USA (including Puerto Rico)...

  6. Going up in Smoke? A Review of nAChRs-based Treatment Strategies for Improving Cognition in Schizophrenia

    Science.gov (United States)

    Boggs, Douglas L.; Carlson, Jon; Cortes-Briones, Jose; Krystal, John H.; D’Souza, D. Cyril

    2015-01-01

    Cognitive impairment is known to be a core deficit in schizophrenia. Existing treatments for schizophrenia have limited efficacy against cognitive impairment. The ubiquitous use of nicotine in this population is thought to reflect an attempt by patients to self-medicate certain symptoms associated with the illness. Concurrently there is evidence that nicotinic receptors that have lower affinity for nicotine are more important in cognition. Therefore, a number of medications that target nicotinic acetylcholine receptors (nAChRs) have been tested or are in development. In this article we summarize the clinical evidence of nAChRs dysfunction in schizophrenia and review clinical studies testing either nicotine or nicotinic medications for the treatment of cognitive impairment in schizophrenia. Some evidence suggests beneficial effects of nAChRs based treatments for the attentional deficits associated with schizophrenia. Standardized cognitive test batteries have failed to capture consistent improvements from drugs acting at nAChRs. However, more proximal measures of brain function, such as ERPs relevant to information processing impairments in schizophrenia, have shown some benefit. Further work is necessary to conclude that nAChRs based treatments are of clinical utility in the treatment of cognitive deficits of schizophrenia. PMID:24345265

  7. Cross-Border Partnerships in Higher Education: Strategies and Issues. International Studies in Higher Education

    Science.gov (United States)

    Sakamoto, Robin, Ed.; Chapman, David, Ed.

    2012-01-01

    "Cross-border Partnerships in Higher Education" looks beyond student and faculty exchanges to examine the myriad ways international colleges and universities work together as institutions. These partnerships have involved the creation of branch campuses, joint research and technology initiatives, collaboration in strengthening…

  8. College Higher Education in England 1944-66 and 1997-2010

    Science.gov (United States)

    Parry, Gareth

    2016-01-01

    As a contribution to the history of higher education in English further education colleges, two policy episodes are sketched and compared. Both periods saw attempts to expand courses of higher education outside the universities. In the first, ahead of policies to concentrate non-university higher education in the strongest institutions, efforts…

  9. Disability and Equity in Higher Education Accessibility

    Science.gov (United States)

    Alphin, Henry C., Jr., Ed.; Lavine, Jennie, Ed.; Chan, Roy Y., Ed.

    2017-01-01

    Education is the foundation to almost all successful lives. It is vital that learning opportunities are available on a global scale, regardless of individual disabilities or differences, and to create more inclusive educational practices. "Disability and Equity in Higher Education Accessibility" is a comprehensive reference source for…

  10. Fostering Creative Problem Solvers in Higher Education

    DEFF Research Database (Denmark)

    Zhou, Chunfang

    2016-01-01

    to meet such challenges. This chapter aims to illustrate how to understand: 1) complexity as the nature of professional practice; 2) creative problem solving as the core skill in professional practice; 3) creativity as interplay between persons and their environment; 4) higher education as the context......Recent studies have emphasized issues of social emergence based on thinking of societies as complex systems. The complexity of professional practice has been recognized as the root of challenges for higher education. To foster creative problem solvers is a key response of higher education in order...... of fostering creative problem solvers; and 5) some innovative strategies such as Problem-Based Learning (PBL) and building a learning environment by Information Communication Technology (ICT) as potential strategies of creativity development. Accordingly, this chapter contributes to bridge the complexity...

  11. Book review of Revolution in Higher Education

    Directory of Open Access Journals (Sweden)

    Jennifer Anna Kepka

    2017-09-01

    Full Text Available In Revolution in Higher Education, Georgia Tech Professor Richard DeMillo contrasts the rapid innovations made in online learning by a small band of interested, outside-of-academia adventurers with the slow progress made within the ivory tower. DeMillo follows innovators with now-familiar names and projects like Coursera and Udacity through their startup phases, describing motives and methods, with an insider's view at their effects on college learning. Then, after a thorough lesson in the history of the academy, DeMillo argues that adherence to academic tradition will not save higher education. In fact, he says, only flexibility and speed can help colleges and universities meet the challenges of today and the inevitable disintegration of higher education as we know it of tomorrow.

  12. Cyberbullying in Higher Education

    Science.gov (United States)

    Minor, Maria A.; Smith, Gina S.; Brashen, Henry

    2013-01-01

    Bullying has extended beyond the schoolyard into online forums in the form of cyberbullying. Cyberbullying is a growing concern due to the effect on its victims. Current studies focus on grades K-12; however, cyberbullying has entered the world of higher education. The focus of this study was to identify the existence of cyberbullying in higher…

  13. The external benefits of higher education

    OpenAIRE

    Hermannsson, Kristinn; Lisenkova, Katerina; Lecca, Patrizio; McGregor, Peter G.; Swales, J. Kim

    2017-01-01

    The private market benefits of education are widely studied at the micro level, although the magnitude of their macroeconomic impact is disputed. However, there are additional benefits of education, which are less well understood. In this paper the macroeconomic effects of external benefits of higher education are estimated using the “micro-to-macro” simulation approach. Two types of externalities are explored: technology spillovers and productivity spillovers in the labour market. These link...

  14. Overconfidence of Vocational Education Students When Entering Higher Education

    Science.gov (United States)

    Bowden, Mark P.; Abhayawansa, Subhash; Bahtsevanoglou, John

    2015-01-01

    Purpose: There is evidence that students who attend Technical and Further Education (TAFE) prior to entering higher education underperform in their first year of study. The purpose of this paper is to examine the role of self-efficacy in understanding the performance of students who completed TAFE in the previous year in a first year subject of…

  15. Higher Education as a Pedagogical Site for Citizenship Education

    Science.gov (United States)

    Davids, Nuraan; Waghid, Yusef

    2016-01-01

    That the issue of violence sits uneasily on the conscience of higher education is evident in the view that educated people are as likely as uneducated people to participate in violence. The concern of conscience is equally prevalent in the view that the public role of the university is "the responsibility of a community of thinking".…

  16. Corporate real estate strategies for future higher education

    NARCIS (Netherlands)

    Ronald Beckers; Driessen Jasper

    2017-01-01

    Purpose – This paper aims to explore the alignment of Corporate Real Estate (CRE) strategies of Dutch Universities of Applied Sciences (UAS) with the developments in higher education. Methodology/approach – The paper first illustrates the key developments in higher education learning and

  17. In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening.

    Science.gov (United States)

    Dey, Raja; Chen, Lin

    2011-04-01

    Nicotinic acetylcholine receptors (nAChR) are pentameric ligand gated ion channels whose activity can be modulated by endogenous neurotransmitters as well as by synthetic ligands that bind the same or distinct sites from the natural ligand. The subtype of α7 nAChR has been considered as a potenial therapeutic target for Alzheimer's disease, schizophrenia and other neurological and psychiatric disorders. Here we have developed a homology model of α7 nAChR based on two high resolution crystal structures with Brookhaven Protein Data Bank (PDB) codes 2QC1 and 2WN9 for threading on one monomer and then for building a pentamer, respectively. A number of small molecule binding sites are identified using Pocket Finder (J. An, M. Tortov, and R. Abagyan, Molecular & Cellular Proteomics, 4.6, 752-761 (2005)) of Internal Coordinate Mechanics (ICM). Remarkably, these computer-identified sites match perfectly with ordered solvent densities found in the high-resolution crystal structure of α1 nAChR, suggesting that the surface cavities in the α7 nAChR model are likely binding sites of small molecules. A high throughput virtual screening by flexible ligand docking of 5008 small molecule compounds was performed at three potential allosteric modulator (AM) binding sites of α7 nAChR using Molsoft ICM software (R. Abagyan, M. Tortov and D. Kuznetsov, J Comput Chem 15, 488-506, (1994)). Some experimentally verified allosteric modulators of α7 like CCMI comp-6, LY 7082101, 5-HI, TQS, PNU-120596, genistein, and NS-1738 ranked among top 100 compounds, while the rest of the compounds in the list could guide further search for new allosteric modulators.

  18. Information Technology from Theory to Practice in Higher Education Structure

    OpenAIRE

    Tooraj Sadeghi; Zahra Piroziyan; Mehrdad Ebrahimpur

    2016-01-01

    In the past two decades, developments process of higher education dependence on the increased demand for admission to higher education, development of communication technologies, need for human resource development, rapid technological changes, accumulated knowledge and information and leads to serious challenges and changes in the role of universities and higher education in the new millennium. So dramatic changes of higher education and move it towards the universalization and interpreta...

  19. The Structure of t he Recreation Education in Higher Education in Turkey

    Directory of Open Access Journals (Sweden)

    M. Murat KIZANLIKLI

    2014-07-01

    Full Text Available By the effects of intense industrialization, technology and working conditions, how people spend their limited free time became an important issue. The importance of using leisure time effect ively and efficiently has an importance and necessity for the education of recreation which can be defined as activities in which people spend their leisure time with satisfying and revitalizing doings. Recreation education, whose beginning is under the s port education, has started at faculties of tourism since 2009. This is a new field in tourism education in Turkey when it’s compared with the examples of the world. Thus, the main objective of this study is to investigate structure and current status of r ecreation education in higher education. For this purpose, dealing with the process of the recreational education, the present situation and the educational structure of the recreational education at higher schools in Turkey has been investigated. Also, re creation education was investigated with the structuring in undergraduate, graduate as well as tourism education and sports education. Besides, in order to put the recreation of recreation education with other disciplines, graduate theses have been investi gated by the programs. According to the data obtained, it has been found out that recreation education at undergraduate level was largely performed in Higher Schools of Physical Education and Sports and the theses prepared were organized under Graduate Sch ool of Natural and Applied Sciences and on Landscape Architecture. This study is aimed to be a resource that manages to compile wide range of information for the future studies.

  20. Blended Learning: enabling Higher Education Reform

    Directory of Open Access Journals (Sweden)

    Kathleen Matheos

    2018-01-01

    Full Text Available Blended learning research and practice have been areas of growth for two decades in Canada, with over 95% of Canadian higher education institutions involved in some form of blended learning. Despite strong evidence based research and practice blended learning, for the most part, has remained at sidelined in Canadian universities. The article argues the need for blended learning to situate itself within the timely and crucial Higher Education Reform (HER agenda. By aligning the affordances of blended learning with the components of HER, blended learning can clearly serve as an enabler for HER.

  1. Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells.

    Science.gov (United States)

    Qian, Jie; Mummalaneni, Shobha K; Alkahtani, Reem M; Mahavadi, Sunila; Murthy, Karnam S; Grider, John R; Lyall, Vijay

    2016-01-01

    In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol. However, at present it is not clear if nAChRs are expressed in enteroendocrine cells other than beta cells of the pancreas and enterochromaffin cells, and if they play a role in the synthesis and release of neurohumoral peptides. Accordingly, we investigated the expression and functional role of nAChRs in enteroendocrine STC-1 cells. Our studies using RT-PCR, qRT-PCR, immunohistochemical and Western blotting techniques demonstrate that STC-1 cells express several α and β nAChR subunits. Exposing STC-1 cells to nicotine acutely (24h) or chronically (4 days) induced a differential increase in the expression of nAChR subunit mRNA and protein in a dose- and time-dependent fashion. Mecamylamine, a non-selective antagonist of nAChRs, inhibited the nicotine-induced increase in mRNA expression of nAChRs. Exposing STC-1 cells to nicotine increased intracellular Ca2+ in a dose-dependent manner that was inhibited in the presence of mecamylamine or dihydro-β-erythroidine, a α4β2 nAChR antagonist. Brain-derived neurotrophic factor (BDNF) mRNA and protein were detected in STC-1 cells using RT-PCR, specific BDNF antibody, and enzyme-linked immunosorbent assay. Acute nicotine exposure (30 min) decreased the cellular content of BDNF in STC-1 cells. The nicotine-induced decrease in BDNF was inhibited in the presence of mecamylamine. We also detected α3 and β4 mRNA in intestinal mucosal cells and α3 protein expression in intestinal enteroendocrine cells. We conclude that STC-1 cells and intestinal enteroendocrine cells express nAChRs. In STC-1 cells nAChR expression is modulated by exposure to nicotine in a dose- and time-dependent manner. Nicotine interacts with nAChRs and inhibits BDNF expression in STC-1 cells.

  2. The Roles of Public Higher Education Expenditure and the Privatization of the Higher Education on U.S. States Economic Growth

    Science.gov (United States)

    Curs, Bradley R.; Bhandari, Bornali; Steiger, Christina

    2011-01-01

    Previous empirical literature finds that government expenditure on higher education has a negative, or null, effect on U.S. economic growth rates. This empirical result may be driven by omission of an important variable--the privatization of higher education. Using state-level panel data from 1970 to 2005, this analysis investigates whether the…

  3. External quality assurance agencies and excellence in higher education

    Directory of Open Access Journals (Sweden)

    Josep Grifoll

    2016-07-01

    Full Text Available The article presents briefly the complexity of the concept of “excellence” in higher education. Taking into account this reality, the fundamental question is how agencies can consider this complexity in building up criteria on excellence and the use of the concept “excellence” in their improvement strategies and accountability processes in the sector of higher education. Public-private nature of higher education and its growing internationalisation have significant impact on how excellence in education is described and promoted as a tool.

  4. Fiscal Stress: Worldwide Trends in Higher Education Finance

    NARCIS (Netherlands)

    Vossensteyn, Johan J.

    2004-01-01

    While higher education is regarded of high priority in boosting economic development, public budgets to sustain expansion of higher education systems remain limited around the globe. In practice, this situation of fiscal stress creates an impetus for governments to develop various strategies to meet

  5. Mobile Device Usage in Higher Education

    Science.gov (United States)

    Delcker, Jan; Honal, Andrea; Ifenthaler, Dirk

    2016-01-01

    This paper focuses on mobile device usage of students in higher education. While more and more students embrace mobile devices in their daily life, institutions attempt to profit from those devices for educational purposes. It is therefore crucial for institutional development to identify students' needs and how mobile devices may facilitate these…

  6. Higher education in the face of social challenges

    Directory of Open Access Journals (Sweden)

    Adrián Cuevas Jiménez

    2016-08-01

    Full Text Available Higher education refers to the subsequent training to high school education; that is undergraduate and graduate; whose mission is to preserve; develop and disseminate culture. Throughout the history of higher education it has undergone a process of transformation; mainly due to the development of knowledge and the transformation of society. In the process they highlighted two great moments; in the first; which culminated in the mid-twentieth century; it conceived the higher education institution encompassing all knowledge of society; and who graduated was ready to perform professionally throughout life; the second time; after those dates; it is conceivable that knowledge is no longer exclusive to the institution of higher education; and there can be no efficient performance without continuous training and continuous updating of knowledge. The objective of this work is to point out the general goals and some strategies of the students’ formation of superior education; to confront the big challenges that it faces today the society. To define this goals and strategies four challenge levels are considered: a physical; structural and politicalideological challenges; b challenges around the scientifictechnician and of the knowledge advances; c challenges of the internal structure of the formative process and the access to the superior education; and d challenges in the formation of values in the students. 

  7. Higher Education Students’ Perceptions of Environmental Issues and Media Coverage

    Directory of Open Access Journals (Sweden)

    Keinonen Tuula

    2016-12-01

    Full Text Available This study aims to find higher education students’ perceptions about environmental issues and how the perceptions are related to perceptions of media coverage. This study investigates higher education students’ perceptions of the seriousness of environmental issues and their relation to perceptions of media coverage. Higher education students perceived a global problem, lack of clean water, as most serious environmental problem. Media has had an effect on students’ perceptions on environmental issues: when students perceived the problem as serious they also perceived the information in media concerning it appropriate. Students perceived that the media underestimate and obscure some environmental problems such as biological diversity and global warming. It was concluded that higher education educators need more knowledge of students’, future decision makers’ concerns and perceptions about environmental issues to develop more effective teaching practices in higher education. Through education environmental issues literacy, which is a precursor for engaged protection of the environment, can be fostered. This study offers some insights into higher education students’ perceptions of the media’s role in environmental issues.

  8. The Legalization of Higher Education

    Science.gov (United States)

    Badke, Lara K.

    2017-01-01

    A complete discussion of intellectual property (IP), faculty rights, and the public good requires a thorough framing of higher education's legal context, from which the rise of legalistic criteria (or legalization) and current IP regime have grown.

  9. E-Learning and Educational Innovation in Higher Education in Japan.

    Science.gov (United States)

    Sakamoto, Takashi

    2002-01-01

    Reviews trends in the use of ICT (information and communication technology) in Japanese higher education institutions. Highlights include recent trends in national policy; educational policy; use of communications satellites; broadcasting; Internet use; videoconferencing; issues concerning virtual universities; and use of multimedia. (Author/LRW)

  10. Capacity building for higher education in developing countries

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    "Higher education is the modern world's basic education, but many countries are falling further and further behind". This quote from a recent World Bank publication indicates that the role of the universities as a key driver for societal development is now widely recognized and included...... in the donor policies. However, donor projects are not easy to organize in this area, and the role of the western universities in this area is not easy to identify. The paper presents a case study from Mozambique dealing with a World Bank project in Higher Education. The project was focused on qualitative...... in the donor countries in order to merge the interests of the universities, the Ministry of Science/Education and the national/international donor agencies. It is argued that capacity building for higher education in developing countries should be a generally accepted part of the university strategy portfolio...

  11. Higher education and general studies in Nigeria: A philosophical ...

    African Journals Online (AJOL)

    Higher education and general studies in Nigeria: A philosophical investigation. ... Mgbakoigba: Journal of African Studies ... national policy on education on tertiary or higher education reveals a startling chasm of gap between the goals of the policy through General Studies Programme and their expected actualizations.

  12. Quality Education and the Marketplace: An Exploration of Neoliberalism and its Impact on Higher Education

    Directory of Open Access Journals (Sweden)

    Mandy Frake

    2010-05-01

    Full Text Available This paper is an in attempt to open discussion about the impact of globalization and theories of neoliberalism on higher education. More specifically, viewing higher education institutions as a market place, where the more a product costs, the greater supply and quality of the product should be received; the quality of education received by university students should also reflect this. Considering the conflict between teaching and research in higher education, quality of education becomes questionable. This paper explores issues of neoliberalism resulting in a greater demand for the completion of research in higher education institutions. Furthermore, the imperialism of higher education leading towards the demand for more research, the teaching versus research nexus within universities, and discussion of how these theories impact international students will be examined throughout this paper

  13. Realizing the European Higher Education Area: Berlin Conference of European Higher Education Ministers

    Science.gov (United States)

    European Education, 2004

    2004-01-01

    The Bologna Declaration of June 1999 has put in motion a series of reforms needed to make European higher education more compatible and comparable, more competitive and attractive for European citizens and for citizens and scholars from other continents. In Prague, in May 2001, the ministers took note of the progress so far and added three new…

  14. Higher Education, Academic Communities, and the Intellectual Virtues

    Science.gov (United States)

    Jones, Ward E.

    2012-01-01

    Because higher education brings members of academic communities in direct contact with students, the reflective higher education student is in an excellent position for developing two important intellectual virtues: confidence and humility. However, academic communities differ as to whether their members reach consensus, and their teaching…

  15. Shifting Institutional Boundaries through Cross-Border Higher Education

    Science.gov (United States)

    Amaral, Alberto; Tavares, Orlanda; Cardoso, Sónia; Sin, Cristina

    2016-01-01

    Cross-border higher education (CBHE) has been changing the organizational boundaries of higher education institutions (HEIs). This study aims to analyze the shifting boundaries of Portuguese HEIs through the lens of the identity concept in organization theories, considering three contexts with different levels of regulation: African…

  16. Higher Education Funding in the Netherlands: Recent Developments

    NARCIS (Netherlands)

    Jongbloed, Benjamin W.A.

    2005-01-01

    Mark Rutte, the Assistant Secretary of State for Higher Education in the Netherlands since June 2004, seems to waste no time in launching new ideas and publishing policy papers that - if accepted by Parliament - will thoroughly reshape the Dutch higher education landscape. The Dutch plans closely

  17. Exploring Higher Education Governance: Analytical Models and Heuristic Frameworks

    Directory of Open Access Journals (Sweden)

    Burhan FINDIKLI

    2017-08-01

    Full Text Available Governance in higher education, both at institutional and systemic levels, has experienced substantial changes within recent decades because of a range of world-historical processes such as massification, growth, globalization, marketization, public sector reforms, and the emergence of knowledge economy and society. These developments have made governance arrangements and decision-making processes in higher education more complex and multidimensional more than ever and forced scholars to build new analytical and heuristic tools and strategies to grasp the intricacy and diversity of higher education governance dynamics. This article provides a systematic discussion of how and through which tools prominent scholars of higher education have analyzed governance in this sector by examining certain heuristic frameworks and analytical models. Additionally, the article shows how social scientific analysis of governance in higher education has proceeded in a cumulative way with certain revisions and syntheses rather than radical conceptual and theoretical ruptures from Burton R. Clark’s seminal work to the present, revealing conceptual and empirical junctures between them.

  18. Blue Ocean Strategy for Higher Education

    Science.gov (United States)

    Bragança, Ricardo

    2016-01-01

    In today's higher education world we see a shift in teaching and educational trends that are slowly materializing due to the advent of new technologies, new academic frameworks and the need to adapt to society's incremental advancements. The implementation of reforms, however, did not have the desired outcome since those were applied to an…

  19. The Vision Thing in Higher Education.

    Science.gov (United States)

    Keller, George

    1995-01-01

    It is argued that while the concept of "vision" in higher education has been met with disdain, criticism is based on misconceptions of vision's nature and role--that vision requires a charismatic administrator and that visionaries are dreamers. Educators and planners are urged to use imaginative thinking to connect the institution's and staff's…

  20. Globalization of higher education and its implications for Ukraine

    Directory of Open Access Journals (Sweden)

    I.V. Burachek

    2017-08-01

    Full Text Available The research is devoted to the studying of the process of establishment of higher education in Ukraine, which as well as other spheres of activity is more and more sensitive to pressure from neighboring countries in current conditions. The globalization culture of the higher education system in Ukraine is primarily associated with the process of innovative education of society. Then a certain complexity takes place, which is conditioned by the continuous inclusion of the totalitarian system into Ukrainian space. As a result, its economy, as well as social and cultural spheres, could not develop freely and independently. That is why advancing the globalization of higher education the Anglo-American model of the world order should be taken as a basis, as well as the expansion of Euro-Atlantic cultural values, which are approved particularly for a foreign higher school, which main advantage is critical thinking, that contributes to the formation of a creative approach to any human activity. The article analyzes the preconditions under which universities cannot rely on the national education system as the current conditions require the implication of the Bologna Process to accelerate the process of European integration. Since last years the formation and consideration of higher education as a commodity has been taking place, where its commercialization goes up to the level of the world market not paying much attention to the quality of educational services. One of the most terrible threats to the national system of higher education is the emergence of providers in education. Considering the poor economic development of the country it leads to increasing the «brain drain» abroad. The article reveals the basic tasks which must be performed by educational institutions in order to engage in competition, where the key targets are to reach the market of educational services maximum and attract potential applicants. At the same time, the globalization of

  1. Quality assessment in higher education using the SERVQUALQ model

    OpenAIRE

    Đonlagić, Sabina; Fazlić, Samira

    2015-01-01

    Economy in Bosnia and Herzegovina is striving towards growth and increased employment and it has been proven by empirical studies worldwide that higher education contributes to socio-economic development of a country. Universities are important for generation, preservation and dissemination of knowledge in order to contribute to socio-economic benefits of a country. Higher education institutions are being pressured to improve value for their activities and providing quality higher education s...

  2. Student satisfaction as an element of education quality monitoring in innovative higher education institution

    Science.gov (United States)

    Razinkina, Elena; Pankova, Ludmila; Trostinskaya, Irina; Pozdeeva, Elena; Evseeva, Lidiya; Tanova, Anna

    2018-03-01

    Topicality of the research is confirmed by increasing student involvement into the educational process, when not only the academic staff and administration participate in the improvement of higher education institution's activity, but also education customers - students. This adds a new dimension to the issue of monitoring education quality and student satisfaction with higher education. This issue echoes the ideas of M. Weber about the relationship between such components as cognitive motivation, personal development and student satisfaction with higher education. Besides, it is essential to focus on the approach of R. Barnet to defining the quality of education with the emphasis on a priority of development of an educational institution as the system that meets customers' needs. Monitoring student satisfaction with education quality has become an integral part of the educational process not only in a number of European universities, which have used this monitoring for decades, but also in Russian universities, which are interested in education quality improvement. Leading universities in Russia, including Peter the Great St. Petersburg Polytechnic University, are implementing policies targeted at increasing student satisfaction with higher education quality. Education quality monitoring as a key element in the system of providing feedback to students contributes greatly to this process.

  3. Social Class Barriers of the Massification of Higher Education in Taiwan

    Science.gov (United States)

    Ru-Jer, Wang

    2012-01-01

    In recent years, the rapid growth of higher education in Taiwan has led to an essential shift from education for the elite to the massification of higher education. Although this massification is making higher education more accessible, one of the main concerns is whether opportunities for higher education are the same among all social classes in…

  4. International Consultation on Peace Education and Research in Higher Education.

    Science.gov (United States)

    Higher Education in Europe, 1986

    1986-01-01

    A January 1986 UNESCO international conference on the role of higher education in promoting international understanding, cooperation, peace, and respect for human rights focused on the nuclear threat and conventional warfare, the role of international governmental and nongovernmental organizations, research and education for peace, and…

  5. Assessing the Quality of the Business and Management Education in Higher Education

    Science.gov (United States)

    Lee, Lung-Sheng; Ko, Hui-Min; Wang, Mei-Tyng; Pan, Ying-Ju

    2014-01-01

    As the third-party planner and implementer of higher education institutional and program evaluations, the Higher Education Evaluation and Accreditation Council of Taiwan (HEEACT) completed program evaluations for all 145 undergraduate business and management (B&M) programs in 43 universities/colleges from 2006 to 2010. In the 145 programs…

  6. Women's Participation in Higher Education in Japan.

    Science.gov (United States)

    Fujimura-Fanselow, Kumiko

    1985-01-01

    The choices that Japanese women make about higher education are, in part, a response to realistic expectations about the functions or rewards of education in their lives and the availability of job opportunities for educated women. Discusses traditional and changing Japanese attitudes toward sex roles, working women, and the types of employment…

  7. Using Critical Pedagogies from Adult Education to Inspire and Challenge Higher Education Students

    Science.gov (United States)

    Kadi-Hanifi, Karima

    2009-01-01

    This interdisciplinary paper is about applying Adult Education methods of learning and teaching to higher education. I argue that higher education students need to be stimulated via interactive methods that improve their motivation and lead them to question the value system/s that exist around them. A Freirean approach as used in the teaching of…

  8. A Review of Twenty-First Century Higher Education

    Science.gov (United States)

    Chan, Shirley

    2018-01-01

    This article is predominantly concerned with the global challenges associated with managing an academic workforce in an era characterised by increased demand for higher education. In scrutinising global trends in higher education and academic workforce management, the article will address two research questions. First, what are the global trends…

  9. Ecuador's Higher Education System in Times of Change

    Science.gov (United States)

    Van Hoof, Hubert B.; Estrella, Mateo; Eljuri, Marie-Isabel; León, Leonardo Torres

    2013-01-01

    Ecuador's higher education system is undergoing dramatic changes. The National Constitution of 2008 and the Higher Education Law of 2010 have changed the way Ecuador's universities are funded, administered, and accredited. The importance of research was elevated and drastic changes were made to the academic qualifications and employment conditions…

  10. TBAL: Technology-Based Active Learning in Higher Education

    Science.gov (United States)

    Ghilay, Yaron; Ghilay, Ruth

    2015-01-01

    In many institutions of higher education worldwide, faculty members manage lessons based on information transfer whereas their students become passive listeners. According to international research, passive learning has disadvantages mainly because students do not engage in the lesson. The study introduces a new model for higher education called…

  11. Setting the Stage: Global Competition in Higher Education

    Science.gov (United States)

    Bagley, Sylvia S.; Portnoi, Laura M.

    2014-01-01

    In this chapter, the issue editors set the stage for the chapters that follow by delineating recent developments in higher education and common strategies for creating globally competitive higher education institutions. The editors consider social justice concerns that arise with global competition and contend that contextualized priorities can…

  12. Dynamics in Higher Education Politics: A Theoretical Model

    Science.gov (United States)

    Kauko, Jaakko

    2013-01-01

    This article presents a model for analysing dynamics in higher education politics (DHEP). Theoretically the model draws on the conceptual history of political contingency, agenda-setting theories and previous research on higher education dynamics. According to the model, socio-historical complexity can best be analysed along two dimensions: the…

  13. Current Trends in Higher Education Learning and Teaching

    Science.gov (United States)

    Singh, R. J.

    2012-01-01

    Current trends in higher education learning and teaching focuses on the use of technology, integrated learning through "blended learning" and writing for academic purposes. This introductory article initiates the debate around the context of South African higher education teaching and learning. It does so by contextualizing the South…

  14. Higher education and capacity building in Africa

    DEFF Research Database (Denmark)

    Higher education has recently been recognised as a key driver for societal growth in the Global South and capacity building of African universities is now widely included in donor policies. The question is; how do capacity-building projects affect African universities, researchers and students? U...... is a valuable resource for researchers and postgraduate students in education, development studies, African studies and human geography, as well as anthropology and history.......? Universities and their scientific knowledges are often seen to have universal qualities; therefore, capacity building may appear straightforward. Higher Education and Capacity Building in Africa contests such universalistic notions. Inspired by ideas about the ‘geography of scientific knowledge’ it explores...

  15. The Process of Change in Higher Education Institutions. AAHE-ERIC/Higher Education Research Report, No. 7, 1982.

    Science.gov (United States)

    Nordvall, Robert C.

    Conditions that inhibit change in higher education institutions and various models of the change process are described. Attention is also directed to: organizational character, structural features, planning procedures, key individuals in the change process, and practical advice about change. The major change models for higher education…

  16. Muslim institutions of higher education in postcolonial africa

    CERN Document Server

    Lo, Mbaye

    2016-01-01

    Muslim Institutions of Higher Education in Postcolonial Africa examines the colonial discriminatory practices against Muslim education through control and dismissal and discusses the education reform movement of the post-colonial experience.

  17. Women Technology Leaders: Gender Issues in Higher Education Information Technology

    Science.gov (United States)

    Drury, Marilyn

    2011-01-01

    Women working in higher education information technology (IT) organizations and those seeking leadership positions in these organizations face a double challenge in overcoming the traditionally male-dominated environments of higher education and IT. Three women higher education chief information officers (CIOs) provided their perspectives,…

  18. Educational Ergonomics in Higher Education Institutions in Nigeria ...

    African Journals Online (AJOL)

    ... of works departments constituted the sample. Four research questions and one hypothesis guided the study. Data was collected using a researcher-constructed questionnaire entitled Educational Ergonomics in Higher Institutions questionnaire (EEIHIQ). An observation checklist and interview schedules were also used.

  19. Ethics, Economics and Higher Education: A Comment

    Science.gov (United States)

    Morgan, W. John

    2013-01-01

    This comment was given to an international panel on the economics of education at the invitation of the Beijing Forum, China, on 3 November 2012. It was published in Chinese in Volume 11, 2013, of the "Peking University Education Review". It considers the connections between ethics, economics and policy towards higher education, using a…

  20. Higher Education and Class: Production or Reproduction?

    Science.gov (United States)

    Sotiris, Panagiotis

    2013-01-01

    This article deals with questions relating to the role of education and especially Higher Education in the reproduction of class division in society. Social classes and how they are formed and reproduced has always been one of the greatest challenges for Marxism and social theory in general. The questions regarding the role of education, and…

  1. The Successful Educational Journeys of American Indian Women: Forming Aspirations for Higher Education

    Science.gov (United States)

    Andrade, Maureen Snow

    2014-01-01

    American Indians (AIs) have lower higher education enrollment and completion rates than Whites and most minority groups. AI women, however, participate at higher rates than AI men, White women, and White men. Research has not examined what contributes to their higher education aspirations. This study explored the middle and high school experiences…

  2. Some Distinctive Features of Jesuit Higher Education Today

    Science.gov (United States)

    Currie, Charles L.

    2010-01-01

    The nation's Catholic colleges and universities are recommitting themselves to making their founding visions come alive in increasingly effective and innovative ways. This article describes the Jesuit tradition of higher education, discussing its origins and how it is reflected in the reality and practice of Jesuit higher education today. This is…

  3. Overview: 2017 Professionals in Higher Education Salary Report

    Science.gov (United States)

    Bichsel, Jacqueline; McChesney, Jasper

    2017-01-01

    The "Faculty in Higher Education Survey" collects data from approximately 700 higher education institutions on nearly 250,000 full-time faculty (tenure track and non-tenure track), as well as academic department heads and adjunct (pay-per-course) faculty. Data collected for full-time faculty include: salary, supplemental salary and…

  4. Factors Influencing Assessment Quality in Higher Vocational Education

    Science.gov (United States)

    Baartman, Liesbeth; Gulikers, Judith; Dijkstra, Asha

    2013-01-01

    The development of assessments that are fit to assess professional competence in higher vocational education requires a reconsideration of assessment methods, quality criteria and (self)evaluation. This article examines the self-evaluations of nine courses of a large higher vocational education institute. Per course, 4-11 teachers and 3-10…

  5. Higher Education Students' Perceptions of Environmental Issues and Media Coverage

    Science.gov (United States)

    Keinonen, Tuula; Palmberg, Irmeli; Kukkonen, Jari; Yli-Panula, Eija; Persson, Christel; Vilkonis, Rytis

    2016-01-01

    This study aims to find higher education students' perceptions about environmental issues and how the perceptions are related to perceptions of media coverage. This study investigates higher education students' perceptions of the seriousness of environmental issues and their relation to perceptions of media coverage. Higher education students…

  6. Quantitative Changes in Higher Education Between 1999-2015 in Turkey

    Directory of Open Access Journals (Sweden)

    Leyla YILMAZ FINDIK

    2017-08-01

    Full Text Available Education is the key factor to build and sustain the future of nations and it stands at the center for smart and sustainable growth. Investing on education especially on higher education, is essential for growth and employment as a more skilled and well educated workforce will support further productivity gains, innovation and wealth. Correspondingly, this results in growing and diversifying of higher education system in all countries to compete world-wide in recent decades. The Turkish higher education system has been facing an unprecedented transformation in the last decade. This transformation has been driven by economic and demographic changes. Higher education in Turkey is changing and opening up to increase in size and to respond to increasing demands from society with the efforts of competing in world-wide. The aim of this study is to investigate the quantitative changes in higher education in Turkey shedding light on the expansion in terms of universities, institutions, students, academic staff and schooling ratio in the last fifteen years starting from 1999 till 2015. The results indicate that Turkey has seen a rapid expansion and a substantial rise in the number of enrollment rate in higher education since 1999 but still not enough when compared to OECD countries.

  7. Inclusive Higher Education for Students with Disabilities in Taiwan

    Science.gov (United States)

    Ho, Hua-Kuo

    2004-01-01

    The purpose of this paper was intended to present the current status of inclusive higher education for students with disabilities in Taiwan. Literature review, documentary analysis, and field observation were used to collect the needed information. The history for educating students with disabilities in higher education institutions in Taiwan has…

  8. Globalisation, Higher Education and Pan-Africanism: A Critical Compromise.

    Science.gov (United States)

    Sylvester, Meagan A.

    This paper discusses the relationship between globalization and higher education by highlighting the changes and challenges that beset institutions of higher learning within the new globalizing economy. There are two overarching conditions that are transforming the structures and practices of higher education: (1) globalization; and (2) the…

  9. Exploring Frameworks to Integrate Globalization, Mission, and Higher Education: Case Study Inquiry at Two Higher Education Institutions in the Pacific Northwest

    Science.gov (United States)

    Gustafson, Jacqueline N.

    2011-01-01

    The purpose of this study was to explore the merits of three conceptual frameworks that emerged from a synthesis of literature related to globalization, mission, and higher education. The first framework, higher education and mission, included three frames: important, not important, and emergent. The second framework, globalization and higher…

  10. Quality Education and the Marketplace: An Exploration of Neoliberalism and its Impact on Higher Education

    OpenAIRE

    Mandy Frake

    2008-01-01

    This paper is an in attempt to open discussion about the impact of globalization and theories of neoliberalism on higher education. More specifically, viewing higher education institutions as a market place, where the more a product costs, the greater supply and quality of the product should be received; the quality of education received by university students should also reflect this. Considering the conflict between teaching and research in higher education, quality of education beco...

  11. Creating marketing strategies for higher education institutions

    Directory of Open Access Journals (Sweden)

    Lidia Białoń

    2015-12-01

    Full Text Available The article presents a thesis that the primary premise of creating marketing strategies for higher education institution is a three-dimensional notion of marketing. The first dimension lies in the theoretical notions of the essence of marketing, including the transactional marketing (1.0, relationship marketing (2.0 and spiritual marketing (3.0. The second dimension is formed by methods of marketing research and accurate notions of marketing, while the third are channels of marketing information. Harmonizing these three dimensions is a precondition for effective marketing. Among other conditions for effective strategies there are: aligning goals of the chosen strategy with the mission of higher education institution, correct choice of targeted segments of the market and of marketing tools. The article also gives a sample classification of marketing strategies based on these criteria, with emphasis on the fact, that every higher education institution employs its own strategy.

  12. Teacher's Use of iPads in Higher Education

    Science.gov (United States)

    Churchill, Daniel; Wang, Tianchong

    2014-01-01

    Mobile devices (e.g. iPads or galaxy tab) are increasingly being used in educational contexts. There has been growing investment in higher education institutions in Hong Kong by the HKSAR Education Bureau in relation to educational uses of mobile technology. However, current research into educational applications of this technology is limited.…

  13. Teaching Evaluation Is Very Necessary at Institutions of Higher Education

    Science.gov (United States)

    Daren, Huang

    2009-01-01

    Government supervision over the quality of higher education by means of evaluations, examinations and verifications, or accreditations is a common international practice in terms of monitoring and controlling the quality of higher education. Many countries stipulate by law that institutions of higher education must submit to evaluation by the…

  14. Transitions in U.S. Higher Education: Implications for Geography Learning

    Science.gov (United States)

    Nellis, M. Duane

    2017-01-01

    In the United States, higher education institutions and structures governing higher education are going through dramatic change. The implications of new technology and changing modes of course structure, and evolving federal and state policies have the potential for significant impact on higher education. The historic federal mandates regarding…

  15. Research Productivity and Its Policy Implications in Higher Education Institutions

    Science.gov (United States)

    Quimbo, Maria Ana T.; Sulabo, Evangeline C.

    2014-01-01

    Responding to the Commission on Higher Education's development plan of enhancing research culture among higher education institutions, this study was conducted to analyze the research productivity of selected higher education institutions. It covered five state universities in the Philippines where a total of 377 randomly selected faculty members…

  16. A Conversation: Historiographic Issues in American Higher Education.

    Science.gov (United States)

    Eisenmann, Linda; Hutcheson, Philo A.; Nidiffer, Jana

    1999-01-01

    Introduces three articles that assess the state of higher education history by turning away from the research university. Explains that the articles (1) focus on books that have influenced the historiography of religion, community colleges, and the poor and (2) discuss how recent research might change conceptions of higher education history. (CMK)

  17. Adapting Higher Education through Changes in Academic Work

    Science.gov (United States)

    Courtney, Kathy

    2013-01-01

    Internationally, changes to academic work are a response to the massification of higher education and a changed and changing higher education context. The majority of these adjustments involve a casualisation of academic work, widely characterised as being of a de-skilling nature, alongside the emergence of new, as well as changing, roles that…

  18. Employability: A Contemporary Review for Higher Education Stakeholders

    Science.gov (United States)

    Small, Lynlea; Shacklock, Kate; Marchant, Teresa

    2018-01-01

    Higher education institutions are under pressure to produce employable graduates who are required to contribute to the sustainability of strong economic growth and development. As such, the onus is on the higher education sector to present graduates to the labour market who are both work ready and have attained employability. This article…

  19. Funding Us Higher Education: Policy Making Theories Reviewed

    Science.gov (United States)

    Cooley, Asya

    2015-01-01

    Higher education policy and politics in the United States (US) has been an issue of studies for several decades. Since the 1960s, researchers have been attempting to understand, explain and extrapolate on the relationships between higher education funding and political institutions. This review attempts to assess recent studies concerned with US…

  20. Higher Education Beyond Faculties: Interdisciplinary Education in Care and Technology.

    Science.gov (United States)

    Sponselee, Anne-Mie A G; Van Hoof, Joost

    2017-01-01

    A Centre of Healthcare and Technology of a Dutch University of Applied Sciences, is presented - and illustrated by project examples - to show how the transitions in the sectors of health care and technology can result in interdisciplinary education in care and technology by means of higher education beyond faculties.

  1. Optimal admission to higher education

    DEFF Research Database (Denmark)

    Albæk, Karsten

    2016-01-01

    that documents the relevance of theory and illustrates how to apply optimal admission procedures. Indirect gains from optimal admission procedures include the potential for increasing entire cohorts of students' probability of graduating with a higher education degree, thereby increasing the skill level...

  2. Danish aid to higher education

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    2016-01-01

    This piece comments on the role of higher education and universities in achieving the goals of Agenda 2030. It also asks if global academic collaboration is a new form of colonization or if researchers from the North can assist in decolonising the academy....

  3. Functionality and stability data of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology

    Directory of Open Access Journals (Sweden)

    Luis F. Padilla-Morales

    2016-03-01

    Full Text Available The presented data provides additional information about the assessment of affinity purified nicotinic acetylcholine receptor (nAChR rich membrane solubilized with long chain (16 saturated carbons lysophospholipid with glycerol headgroup (LFG-16. The assessment of stability and functionality of solubilized membrane protein is a critical step prior to further crystallization trails. One of the key factors for this task is the appropriate choice of a detergent that can support nAChR activity and stability comparable to the crude membranes. The stability of the nAChR-LFG-16 complex incorporated into lipid cubic phase (LCP was monitored for a period of 30 days by means of fluorescence recovery after photobleaching (FRAP and the functionality was evaluated after its incorporation into Xenopus oocyte by means of the two electrode voltage clamp technique. Keywords: Detergents, Fluorescence recovery after photobleaching, Lipidic Cubic Phase, nAChR, Planar lipid bilayer, Two-electrode voltage clamp

  4. Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista

    Directory of Open Access Journals (Sweden)

    Xiaorong Xu Parks

    2017-11-01

    Full Text Available In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells. Electrical stimulation of VENs releases acetylcholine (ACh at these synapses to exert diverse effects on afferent background discharge including rapid inhibition of bouton afferents and excitation of calyx-bearing afferents. Efferent-mediated inhibition is most pronounced in bouton afferents innervating type II hair cells near the torus, but becomes progressively smaller and briefer when moving longitudinally through the crista toward afferents innervating the planum. Sharp-electrode recordings have inferred that efferent-mediated inhibition of bouton afferents requires the sequential activation of alpha9-containing nicotinic ACh receptors (α9*nAChRs and small-conductance, calcium-dependent potassium channels (SK in type II hair cells. Gradations in the strength of efferent-mediated inhibition across the crista likely reflect variations in α9*nAChRs and/or SK activation in type II hair cells from those different regions. However, in turtle cristae, neither inference has been confirmed with direct recordings from type II hair cells. To address these gaps, we performed whole-cell, patch-clamp recordings from type II hair cells within a split-epithelial preparation of the turtle posterior crista. Here, we can easily visualize and record hair cells while maintaining their native location within the neuroepithelium. Consistent with α9*nAChR/SK activation, ACh-sensitive currents in type II hair cells were inward at hyperpolarizing potentials but reversed near −90 mV to produce outward currents that typically peaked around −20 mV. ACh-sensitive currents were largest in torus hair cells but absent from hair cells near the planum. In current clamp recordings under zero-current conditions, ACh robustly hyperpolarized type II hair cells. ACh

  5. Leadership Competency Development: A Higher Education Responsibility

    Science.gov (United States)

    Seemiller, Corey

    2016-01-01

    Moving from why, how, and what, this chapter closes with a focus on how we know the outcomes of leadership education. This final chapter provides an overview of leadership competency development as a critical component of higher education.

  6. Federalism and Lander Autonomy: The Higher Education Policy Network in the Federal Republic of Germany. Studies in Higher Education Dissertation Series.

    Science.gov (United States)

    Onestini, Cesare

    This study traces the development of the German higher education system, examining the development of higher education policies from the postwar years to the postunification period. It focuses on federalism and the relative positions of"Lander" (German states) and the government of the Federal Republic (FRG) as revealed in higher…

  7. Frequency Rates and Correlates of Contrapower Harassment in Higher Education

    Science.gov (United States)

    DeSouza, Eros R.

    2011-01-01

    The current study investigated incivility, sexual harassment, and racial-ethnic harassment simultaneously when the targets were faculty members and the perpetrators were students (i.e., academic contrapower harassment; ACH). The sample constituted 257 faculty members (90% were White and 53% were women) from a medium-sized state university in the…

  8. HIGHER EDUCATION SPILLOVER – THE HIGHWAY TO REGIONAL SUCCESS

    Directory of Open Access Journals (Sweden)

    Helena Štimac

    2015-12-01

    Full Text Available The aim of this paper is to answer how regional sector influences higher education. These regional differences generate interest in the study of economic growth and regional development. The crucial role in spillover process is played by higher education institutions as they are the promoters of research and knowledge that stems from it. Higher education institutions should be involved in the innovation system at regional level in order to create a stimulating and competitive environment for the future growth and development. Additionally, the paper presents, compares and analyses contemporary phenomena related to the regional dimension of innovation and the role of higher education institutions in Croatia, Hungary and Slovenia. Besides teaching and research, higher education institutions must develop and emerge a “third mission” through research and technology commercialization, joint research projects, spin-off formation, mobility of researchers/teachers/students to industry and vice versa, and involvement in local and regional development projects as well. However, this is not only about knowledge spillover in some delimitated sectors, but transforming and reinvigorating the whole society on regional level.

  9. Promoting Distance Education in Higher Education in Cape Verde and Mozambique

    Science.gov (United States)

    Ramos, Fernando; Taju, Gulamo; Canuto, Louisette

    2011-01-01

    Over the past six years, the authors have been project leaders for three distance education initiatives in Cape Verde and Mozambique: (1) a blended learning master's degree in multimedia in education for faculty in Cape Verdean public higher education institutions (2005-2008); (2) a teacher training programme for 1375 elementary teachers provided…

  10. Learning from the Field: Innovating China's Higher Education System

    International Development Research Centre (IDRC) Digital Library (Canada)

    2008-04-15

    Apr 15, 2008 ... Learning from the Field: Innovating China's Higher Education System ... to translating China's higher education policy reforms into practice. The editors. Ronnie Vernooy is Senior Program Specialist, International Development ...

  11. Corruption Hierarchies in Higher Education in the Former Soviet Bloc

    Science.gov (United States)

    Osipian, Ararat L.

    2009-01-01

    Corruption in higher education is known but not described theoretically. Decentralization and privatization of higher education and the increasing scale and scope of corruption in higher education in the former Soviet Bloc, as well as numerous other countries, urges better understanding of the problem within the context of socio-economic…

  12. IMPACT OF FOREIGN DIRECT INVESTMENT ON HIGHER EDUCATION

    OpenAIRE

    Kalpana Singh; Dr. Alka Awasthi

    2017-01-01

    The purpose of this paper is to examine how Foreign Direct investment (FDI) can be leveraged to enhance its impact on Higher Education. This paper attempts to discuss the possibilities of bringing quality, excellence and more opportunities in “Higher education” through the FDI route. FOREIGN DIRECT INVESTMENT: Education sector is growing day by day and gaining lots of importance in the world and India as well. Education Industry is likely to grow by the Gross Enrolment Ratio (GER) by 2020. Fo...

  13. Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis.

    Science.gov (United States)

    Abiusi, Emanuela; D'Alessandro, Manuela; Dieterich, Klaus; Quevarec, Loic; Turczynski, Sandrina; Valfort, Aurore-Cecile; Mezin, Paulette; Jouk, Pierre Simon; Gut, Marta; Gut, Ivo; Bessereau, Jean Louis; Melki, Judith

    2017-10-15

    Arthrogryposis multiplex congenita (AMC) is a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. Homozygosity mapping of disease loci combined with whole exome sequencing in a consanguineous family presenting with lethal AMC allowed the identification of a homozygous frameshift deletion in UNC50 gene (c.750_751del:p.Cys251Phefs*4) in the index case. To assess the effect of the mutation, an equivalent mutation in the Caenorhabditis elegans orthologous gene was created using CRISPR/Cas9. We demonstrated that unc-50(kr331) modification caused the loss of acetylcholine receptor (AChR) expression in C. elegans muscle. unc-50(kr331) animals were as resistant to the cholinergic agonist levamisole as unc-50 null mutants suggesting that AChRs were no longer expressed in this animal model. This was confirmed by using a knock-in strain in which a red fluorescent protein was inserted into the AChR locus: no signal was detected in unc-50(kr331) background, suggesting that UNC-50, a protein known to be involved in AChR trafficking, was no longer functional. These data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. CLS to higher education administrator: the price they paid.

    Science.gov (United States)

    Campbell, Suzanne; LaCost, Barbara Y

    2010-01-01

    To identify the barriers and/or obstacles these women experienced during their career paths as women clinical laboratory scientists who transitioned to higher education administration. To identify how being a woman influenced their careers as higher education administrators. A multi-site case study design was selected for this qualitative research involving a purposive sample of eight research participants. Data collection was guided by ten open-ended questions in seven face-to-face and one telephone semi-formal interviews. The purposive sample included women clinical laboratory scientists who held a current higher education administrative position at the dean's level, including associate and assistant dean positions, in a university setting. The participants were located in eight higher education institutions in Nebraska, Illinois, Ohio, Tennessee, Missouri, and Texas. The price women pay, gender considerations, a need for balance, existence/absence of the glass ceiling for women in higher education administration. Making personal sacrifices, struggling with gender stereotypes, being a woman, knowing you are okay, and possessing the ability to separate the personal from the professional were identified by this group of women as challenging experiences as they obtained and maintained a position as a higher education administrator. Additionally, they described the need for balance, a support system, and how they successfully managed their marriage, family, and career. The participants presented conflicting statements concerning

  15. Student Drop-Out from German Higher Education Institutions

    Science.gov (United States)

    Heublein, Ulrich

    2014-01-01

    28% of students of any one year currently give up their studies in bachelor degree programmes at German higher education institutions. Drop-out is to be understood as the definite termination in the higher education system without obtaining an academic degree. The drop-out rate is thereby calculated with the help of statistical estimation…

  16. Higher Education Prices and Price Indexes. 1976 Supplement.

    Science.gov (United States)

    Halstead, Kent D.

    The 1976 supplement presents higher education price index data for fiscal years 1971 through 1976. The basic study, "Higher Education Prices and Price Indexes" (ED 123 996) presents complete descriptions of the indexes together with index values and price data for fiscal years 1961 through 1974. Indexes are presented for research and development,…

  17. Business Models Associated with Distance Learning in Higher Education

    Science.gov (United States)

    Wang, Shouhong; Wang, Hai

    2017-01-01

    Textbook prices are continuously rising in higher education. This paper analyzes a business model which makes commercial textbooks more expensive, and explains why this issue tends to be more severe in the field of distance learning in higher education. It reports a case of adoption of open educational resources (OER) textbook for an online course…

  18. Higher Education and Citizenship: "The Full Range of Purposes"

    Science.gov (United States)

    Zgaga, Pavel

    2009-01-01

    This article discusses citizenship education in the context of the purposes and roles of higher education. The social and political changes in Europe of the last two decades have had an immense impact on the understanding of these roles and purposes, defining the university's mission and steering the national systems of higher education. The…

  19. Shifting Sands: Reflections from the Field of Higher Education.

    Science.gov (United States)

    Harrison, Barbara

    2001-01-01

    Discusses the benefits of reflection in higher education, highlighting one academic's reflections on herself as a woman in academia and how the attitudes she learned during her childhood and youth created problems during her own higher education and in her work as an academic. Also looks at educational discrimination against other minority groups.…

  20. Innovations in higher medical education

    Directory of Open Access Journals (Sweden)

    Popkov V.M.

    2014-03-01

    Full Text Available The article is devoted to the innovations in the higher medical education. Particular attention in this sphere is paid to the detailed analysis of the subject as a mechanism of cognition and psycho-emotional aspect. It should be noticed that the development of the university education demands the integration of functional systems to study the general medicine and the art of healing. In conclusion it has been found out that the new methodological approach is necessary to bring the teacher closer to the subject particularly to integrate the relation of the opposites.