Higher-derivative terms in one-loop effective action for general trajectories of D-particles in Matrix theory

International Nuclear Information System (INIS)

Okawa, Yuji

1999-01-01

The one-loop effective action for general trajectories of D-particles in Matrix theory is calculated in the expansion with respect to the number of derivatives up to six, which gives the equation of motion consistently. The result shows that the terms with six derivatives vanish for straight-line trajectories, however, they do not vanish in general. This provides a concrete example that non-renormalization of twelve-fermion terms does not necessarily imply that of six-derivative terms

Higher derivative couplings and massive supergravity in three dimensions

Energy Technology Data Exchange (ETDEWEB)

Kuzenko, Sergei M.; Novak, Joseph [School of Physics M013, The University of Western Australia,35 Stirling Highway, Crawley W.A. 6009 (Australia); Tartaglino-Mazzucchelli, Gabriele [School of Physics M013, The University of Western Australia,35 Stirling Highway, Crawley W.A. 6009 (Australia); Instituut voor Theoretische Fysica, KU Leuven,Celestijnenlaan 200D, B-3001 Leuven (Belgium)

2015-09-14

We develop geometric superspace settings to construct arbitrary higher derivative couplings (including R{sup n} terms) in three-dimensional supergravity theories with N≤3 by realising them as conformal supergravity coupled to certain compensators. For all known off-shell supergravity formulations, we construct supersymmetric invariants with up to and including four derivatives. As a warming-up exercise, we first give a new and completely geometric derivation of such invariants in N=1 supergravity. Upon reduction to components, they agree with those given in http://arxiv.org/abs/0907.4658 and http://arxiv.org/abs/1005.3952. We then carry out a similar construction in the case of N=2 supergravity for which there exist two minimal formulations that differ by the choice of compensating multiplet: (i) a chiral scalar multipet; (ii) a vector multiplet. For these formulations all four derivative invariants are constructed in completely general and gauge independent form. For a general supergravity model (in the N=1 and minimal N=2 cases) with curvature-squared and lower order terms, we derive the superfield equations of motion, linearise them about maximally supersymmetric backgrounds and obtain restrictions on the parameters that lead to models for massive supergravity. We use the non-minimal formulation for N=2 supergravity (which corresponds to a complex linear compensator) to construct a novel consistent theory of massive supergravity. In the case of N=3 supergravity, we employ the off-shell formulation with a vector multiplet as compensator to construct for the first time various higher derivative invariants. These invariants may be used to derive models for N=3 massive supergravity. As a bi-product of our analysis, we also present superfield equations for massive higher spin multiplets in (1,0), (1,1) and (2,0) anti-de Sitter superspaces.

On the dimensional reduction of a gravitational theory containing higher-derivative terms

International Nuclear Information System (INIS)

Pollock, M.D.

1990-02-01

From the higher-dimensional gravitational theory L-circumflex=R-circumflex-2Λ-circumflex-α-circumflex 1 R-circumflex 2 =α-circumflex 2 R-circumflex AB R-circumflex AB -α-circumflex 3 R-circumflex ABCD R-circumflex ABCD , we derive the effective four-dimensional Lagrangian L. (author). 12 refs

Higher-order terms in the nuclear-energy-density functional

International Nuclear Information System (INIS)

Carlsson, B. G.; Borucki, M.; Dobaczewski, J.

2009-01-01

One of the current projects at the Department of Physics in the University of Jyvaeskylae is to explore more general forms of the Skyrme energy-density functional (EDF). The aim is to find new phenomenological terms which are sensitive to experimental data. In this context we have extended the Skyrme functional by including terms which contain higher orders of derivatives allowing for a better description of finite range effects. This was done by employing an expansion in derivatives in a spherical-tensor formalism [1] motivated by ideas of the density-matrix expansion. The resulting functionals have different number of free parameters depending on the order in derivatives and assumed symmetries, see Fig. 1. The usual Skyrme EDF is obtained as a second order expansion while we keep terms up to sixth order.(author)

On higher derivative gravity

International Nuclear Information System (INIS)

Accioly, A.J.

1987-01-01

A possible classical route conducting towards a general relativity theory with higher-derivatives starting, in a sense, from first principles, is analysed. A completely causal vacuum solution with the symmetries of the Goedel universe is obtained in the framework of this higher-derivative gravity. This very peculiar and rare result is the first known vcuum solution of the fourth-order gravity theory that is not a solution of the corresponding Einstein's equations.(Author) [pt

On (in)stabilities of perturbations in mimetic models with higher derivatives

Energy Technology Data Exchange (ETDEWEB)

Zheng, Yunlong; Shen, Liuyuan [Department of Physics, Nanjing University, Nanjing 210093 (China); Mou, Yicen; Li, Mingzhe, E-mail: zylakx@163.com, E-mail: sly12271103@163.com, E-mail: moinch@mail.ustc.edu.cn, E-mail: limz@ustc.edu.cn [Interdisciplinary Center for Theoretical Study, University of Science and Technology of China, Hefei, Anhui 230026 (China)

2017-08-01

Usually when applying the mimetic model to the early universe, higher derivative terms are needed to promote the mimetic field to be dynamical. However such models suffer from the ghost and/or the gradient instabilities and simple extensions cannot cure this pathology. We point out in this paper that it is possible to overcome this difficulty by considering the direct couplings of the higher derivatives of the mimetic field to the curvature of the spacetime.

Holographic metal-insulator transition in higher derivative gravity

Energy Technology Data Exchange (ETDEWEB)

Ling, Yi, E-mail: lingy@ihep.ac.cn [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Shanghai Key Laboratory of High Temperature Superconductors, Shanghai, 200444 (China); Liu, Peng, E-mail: liup51@ihep.ac.cn [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Wu, Jian-Pin, E-mail: jianpinwu@mail.bnu.edu.cn [Institute of Gravitation and Cosmology, Department of Physics, School of Mathematics and Physics, Bohai University, Jinzhou 121013 (China); Shanghai Key Laboratory of High Temperature Superconductors, Shanghai, 200444 (China); Zhou, Zhenhua, E-mail: zhouzh@ihep.ac.cn [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

2017-03-10

We introduce a Weyl term into the Einstein–Maxwell-Axion theory in four dimensional spacetime. Up to the first order of the Weyl coupling parameter γ, we construct charged black brane solutions without translational invariance in a perturbative manner. Among all the holographic frameworks involving higher derivative gravity, we are the first to obtain metal-insulator transitions (MIT) when varying the system parameters at zero temperature. Furthermore, we study the holographic entanglement entropy (HEE) of strip geometry in this model and find that the second order derivative of HEE with respect to the axion parameter exhibits maximization behavior near quantum critical points (QCPs) of MIT. It testifies the conjecture in that HEE itself or its derivatives can be used to diagnose quantum phase transition (QPT).

On butterfly effect in higher derivative gravities

Energy Technology Data Exchange (ETDEWEB)

Alishahiha, Mohsen [School of Physics, Institute for Research in Fundamental Sciences (IPM),P.O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Davody, Ali; Naseh, Ali; Taghavi, Seyed Farid [School of Particles and Accelerators, Institute for Research in Fundamental Sciences (IPM),P.O. Box 19395-5531, Tehran (Iran, Islamic Republic of)

2016-11-07

We study butterfly effect in D-dimensional gravitational theories containing terms quadratic in Ricci scalar and Ricci tensor. One observes that due to higher order derivatives in the corresponding equations of motion there are two butterfly velocities. The velocities are determined by the dimension of operators whose sources are provided by the metric. The three dimensional TMG model is also studied where we get two butterfly velocities at generic point of the moduli space of parameters. At critical point two velocities coincide.

On butterfly effect in higher derivative gravities

International Nuclear Information System (INIS)

Alishahiha, Mohsen; Davody, Ali; Naseh, Ali; Taghavi, Seyed Farid

2016-01-01

We study butterfly effect in D-dimensional gravitational theories containing terms quadratic in Ricci scalar and Ricci tensor. One observes that due to higher order derivatives in the corresponding equations of motion there are two butterfly velocities. The velocities are determined by the dimension of operators whose sources are provided by the metric. The three dimensional TMG model is also studied where we get two butterfly velocities at generic point of the moduli space of parameters. At critical point two velocities coincide.

N=2 type II - heterotic duality and higher derivative F-terms

International Nuclear Information System (INIS)

Antoniadis, I.; Narain, K.S.; Taylor, T.R.

1995-07-01

We test the recently conjectured duality between N-2 supersymmetric type II and heterotic string models by analyzing a class of higher dimensional interactions in the respective low-energy Lagrangians. These are F-terms of the form F g W 2g where W is the gravitational superfield. On the type II side these terms are generated at the g-loop level and in fact are given by topological partition functions of the twisted Calabi-Yan sigma model. We show that on the heterotic side these terms arise at the one-loop level. We study in detail a rank 3 example and show that the corresponding couplings, F g satisfy the same holomorphic anomaly equations as in the type II case. Moreover we study the leading singularities of F g 's on the heterotic side, near the enhanced symmetry point and show that they are universal poles of order 2g - 2 with coefficients that are given by the Euler number of the moduli space of genus-g Riemann surfaces. This confirms a recent conjecture that the physics near the conifold singularity is governed by c=1 string theory at the self-dual point. (author). 24 refs

Higher-derivative generalization of conformal mechanics

Science.gov (United States)

Baranovsky, Oleg

2017-08-01

Higher-derivative analogs of multidimensional conformal particle and many-body conformal mechanics are constructed. Their Newton-Hooke counterparts are derived by applying appropriate coordinate transformations.

Ineffective higher derivative black hole hair

Science.gov (United States)

Goldstein, Kevin; Mashiyane, James Junior

2018-01-01

Inspired by the possibility that the Schwarzschild black hole may not be the unique spherically symmetric vacuum solution to generalizations of general relativity, we consider black holes in pure fourth order higher derivative gravity treated as an effective theory. Such solutions may be of interest in addressing the issue of higher derivative hair or during the later stages of black hole evaporation. Non-Schwarzschild solutions have been studied but we have put earlier results on a firmer footing by finding a systematic asymptotic expansion for the black holes and matching them with known numerical solutions obtained by integrating out from the near-horizon region. These asymptotic expansions can be cast in the form of trans-series expansions which we conjecture will be a generic feature of non-Schwarzschild higher derivative black holes. Excitingly we find a new branch of solutions with lower free energy than the Schwarzschild solution, but as found in earlier work, solutions only seem to exist for black holes with large curvatures, meaning that one should not generically neglect even higher derivative corrections. This suggests that one effectively recovers the nonhair theorems in this context.

Higher derivative regularization and chiral anomaly

International Nuclear Information System (INIS)

Nagahama, Yoshinori.

1985-02-01

A higher derivative regularization which automatically leads to the consistent chiral anomaly is analyzed in detail. It explicitly breaks all the local gauge symmetry but preserves global chiral symmetry and leads to the chirally symmetric consistent anomaly. This regularization thus clarifies the physics content contained in the consistent anomaly. We also briefly comment on the application of this higher derivative regularization to massless QED. (author)

Critical Combinations of Higher-Order Terms in Einstein-Maxwell Theory and Compactification

Directory of Open Access Journals (Sweden)

Nahomi Kan

2015-01-01

Full Text Available We discuss the role of a particular combination of higher derivative terms in higher dimensional theories, particularly in the background of spontaneous compactification. Two classes of theories are proposed in this paper. The first model as a generalization of the critical gravity with the Maxwell field could have a de Sitter solution. We consider the Lanczos-Lovelock term and Horndeski term as well as the higher-order Maxwell term for the second model, which contains a possible longer expansion time for the inflationary phase. It is interesting that both models can be regarded as the generalization of the Randjbar-Daemi, Salam and Strathdee (RSS model and give the well behavior for inflation stage under the specific assumptions.

Higher derivative super Yang-Mills theories

International Nuclear Information System (INIS)

Bergshoeff, E.; Rakowski, M.; Sezgin, E.

1986-11-01

The most general higher derivative Yang-Mills actions of the type (F 2 +α2F 4 ) which are globally supersymmetric up to order α 2 in six and ten dimensional spacetimes are given. The F 4 -terms turn out to occur in the combination α 2 (tr F 4 - 1/4(tr F 2 ) 2 ), where the trace is over the Lorentz indices. This result agrees with the low energy limit of the open superstring in ten dimensions, where α is the string tension. Surprisingly, the transformation rules of the Yang-Mills multiplet receive order α 2 corrections even in the off-shell formulation. For the case of Abelian Yang-Mills group, the action is expressed in Born-Infeld form with a metric generically given by (1+α 2 F 2 +...). (author)

Second- and Higher-Order Virial Coefficients Derived from Equations of State for Real Gases

Science.gov (United States)

Parkinson, William A.

2009-01-01

Derivation of the second- and higher-order virial coefficients for models of the gaseous state is demonstrated by employing a direct differential method and subsequent term-by-term comparison to power series expansions. This communication demonstrates the application of this technique to van der Waals representations of virial coefficients.…

Higher derivative corrections to incoherent metallic transport in holography

Energy Technology Data Exchange (ETDEWEB)

Baggioli, Matteo [Institut de Física d’Altes Energies (IFAE), Universitat Autónoma de Barcelona,The Barcelona Institute of Science and Technology,Campus UAB, 08193 Bellaterra (Barcelona) (Spain); Crete Center for Theoretical Physics and I.P.P., Department of Physics, University of Crete,71003 Heraklion (Greece); Goutéraux, Blaise [Nordita, KTH Royal Institute of Technology and Stockholm University,Roslagstullsbacken 23, SE-106 91 Stockholm (Sweden); Stanford Institute for Theoretical Physics, Department of Physics, Stanford University,Varian Laboratory of Physics, 382 Via Pueblo Mall, Stanford, CA 94305-4060 (United States); APC, Université Paris 7, CNRS/IN2P3, CEA/IRFU, Obs. de Paris,Sorbonne Paris Cité (UMR du CNRS 7164),Bâtiment Condorcet, 10, rue Alice Domon et Léonie Duquet, F-75205, Paris Cedex 13 (France); Kiritsis, Elias [APC, Université Paris 7, CNRS/IN2P3, CEA/IRFU, Obs. de Paris,Sorbonne Paris Cité (UMR du CNRS 7164),Bâtiment Condorcet, 10, rue Alice Domon et Léonie Duquet, F-75205, Paris Cedex 13 (France); Crete Center for Theoretical Physics and I.P.P., Department of Physics, University of Crete,71003 Heraklion (Greece); Crete Center for Quantum Complexity and Nanotechnology, University of Crete,71003 Heraklion (Greece); Li, Wei-Jia [Institute of Theoretical Physics, School of Physics and Optoelectronic Technology,Dalian University of Technology, 214 School of Physics,2 Linggong road, Ganjingzi District, Dalian 116024, Liaoning Province (China); Crete Center for Theoretical Physics and I.P.P., Department of Physics, University of Crete,71003 Heraklion (Greece)

2017-03-31

Transport in strongly-disordered, metallic systems is governed by diffusive processes. Based on quantum mechanics, it has been conjectured that these diffusivities obey a lower bound D/v{sup 2}≳ℏ/k{sub B}T, the saturation of which provides a mechanism for the T-linear resistivity of bad metals. This bound features a characteristic velocity v, which was later argued to be the butterfly velocity v{sub B}, based on holographic models of transport. This establishes a link between incoherent metallic transport, quantum chaos and Planckian timescales. Here we study higher derivative corrections to an effective holographic action of homogeneous disorder. The higher derivative terms involve only the charge and translation symmetry breaking sector. We show that they have a strong impact on the bound on charge diffusion D{sub c}/v{sub B}{sup 2}≳ℏ/k{sub B}T, by potentially making the coefficient of its right-hand side arbitrarily small. On the other hand, the bound on energy diffusion is not affected.

A classical approach to higher-derivative gravity

International Nuclear Information System (INIS)

Accioly, A.J.

1988-01-01

Two classical routes towards higher-derivative gravity theory are described. The first one is a geometrical route, starting from first principles. The second route is a formal one, and is based on a recent theorem by Castagnino et.al. [J. Math. Phys. 28 (1987) 1854]. A cosmological solution of the higher-derivative field equations is exhibited which in a classical framework singles out this gravitation theory. (author) [pt

One-loop polarization operator of the quantum gauge superfield for 𝒩 = 1 SYM regularized by higher derivatives

Science.gov (United States)

Kazantsev, A. E.; Skoptsov, M. B.; Stepanyantz, K. V.

2017-11-01

We consider the general 𝒩 = 1 supersymmetric gauge theory with matter, regularized by higher covariant derivatives without breaking the BRST invariance, in the massless limit. In the ξ-gauge we obtain the (unrenormalized) expression for the two-point Green function of the quantum gauge superfield in the one-loop approximation as a sum of integrals over the loop momentum. The result is presented as a sum of three parts: the first one corresponds to the pure supersymmetric Yang-Mills theory in the Feynman gauge, the second one contains all gauge-dependent terms, and the third one is the contribution of diagrams with a matter loop. For the Feynman gauge and a special choice of the higher derivative regulator in the gauge fixing term, we analytically calculate these integrals in the limit k → 0. In particular, in addition to the leading logarithmically divergent terms, which are determined by integrals of double total derivatives, we also find the finite constants.

Dynamical symmetry restoration for a higher-derivative four-fermion model in an external electromagnetic field

International Nuclear Information System (INIS)

Elizalde, E.; Gavrilov, S.P.; Shil'nov, Yu.I.

2000-01-01

A four-fermion model with additional higher-derivative terms is investigated in an external electromagnetic field. The effective potential in the leading order of large-N expansion is calculated in external constant magnetic and electric fields. It is shown that, in contrast to the former results concerning the universal character of 'magnetic catalysis' in dynamical symmetry breaking, in the present higher-derivative model the magnetic field restores chiral symmetry broken initially on the tree level. Numerical results describing a second-order phase transition that accompanies the symmetry restoration at the quantum level are presented. (author)

Gauges and functional measures in quantum gravity II: higher-derivative gravity

Energy Technology Data Exchange (ETDEWEB)

Ohta, N. [Kindai University, Department of Physics, Higashi-Osaka, Osaka (Japan); Percacci, R. [International School for Advanced Studies, Trieste (Italy); INFN, Sezione di Trieste, Trieste (Italy); Pereira, A.D. [UERJ-Universidade do Estado do Rio de Janeiro, Departamento de Fisica Teorica, Rio de Janeiro (Brazil)

2017-09-15

We compute the one-loop divergences in a higher-derivative theory of gravity including Ricci tensor squared and Ricci scalar squared terms, in addition to the Hilbert and cosmological terms, on an (generally off-shell) Einstein background. We work with a two-parameter family of parametrizations of the graviton field, and a two-parameter family of gauges. We find that there are some choices of gauge or parametrization that reduce the dependence on the remaining parameters. The results are invariant under a recently discovered ''duality'' that involves the replacement of the densitized metric by a densitized inverse metric as the fundamental quantum variable. (orig.)

Higher derivative corrections to BPS black hole attractors in 4d gauged supergravity

Energy Technology Data Exchange (ETDEWEB)

Hristov, Kiril [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, 1784 Sofia (Bulgaria); Katmadas, Stefanos [Dipartimento di Fisica, Università di Milano-Bicocca,I-20126 Milano (Italy); INFN, Sezione di Milano-Bicocca,I-20126 Milano (Italy); Lodato, Ivano [Department of Physics, IISER Pune,Homi Bhaba Road, Pashan, Pune (India)

2016-05-30

We analyze BPS black hole attractors in 4d gauged supergravity in the presence of higher derivative supersymmetric terms, including a Weyl-squared-type action, and determine the resulting corrections to the Bekenstein-Hawking entropy. The near-horizon geometry AdS{sub 2}×S{sup 2} (or other Riemann surface) preserves half of the supercharges in N=2 supergravity with Fayet-Iliopoulos gauging. We derive a relation between the entropy and the black hole charges that suggests via AdS/CFT how subleading corrections contribute to the supersymmetric index in the dual microscopic picture. Depending on the model, the attractors are part of full black hole solutions with different asymptotics, such as Minkowski, AdS{sub 4}, and hvLif{sub 4}. We give explicit examples for each of the asymptotic cases and comment on the implications. Among other results, we find that the Weyl-squared terms spoil the exact two-derivative relation to non-BPS asymptotically flat black holes in ungauged supergravity.

Inconsistency of Minkowski higher-derivative theories

Energy Technology Data Exchange (ETDEWEB)

Aglietti, Ugo G. [Universita di Roma ' ' La Sapienza' ' , Dipartimento di Fisica, Rome (Italy); Anselmi, Damiano [Universita di Pisa, Dipartimento di Fisica ' ' Enrico Fermi' ' , Pisa (Italy); INFN, Sezione di Pisa, Pisa (Italy)

2017-02-15

We show that Minkowski higher-derivative quantum field theories are generically inconsistent, because they generate nonlocal, non-hermitian ultraviolet divergences, which cannot be removed by means of standard renormalization procedures. By ''Minkowski theories'' we mean theories that are defined directly in Minkowski spacetime. The problems occur when the propagators have complex poles, so that the correlation functions cannot be obtained as the analytic continuations of their Euclidean versions. The usual power counting rules fail and are replaced by much weaker ones. Self-energies generate complex divergences proportional to inverse powers of D'Alembertians. Three-point functions give more involved nonlocal divergences, which couple to infrared effects. We illustrate the violations of the locality and hermiticity of counterterms in scalar models and higher-derivative gravity. (orig.)

Particle production in higher derivative theory

Indian Academy of Sciences (India)

Lemaitre–Robertson–Walker cosmological model during the early stages of the universe is analysed in the framework of higher derivative theory. The universe has been considered as an open thermodynamic system where particle production ...

Higher-order curvature terms and extended inflation

International Nuclear Information System (INIS)

Wang Yun

1990-01-01

We consider higher-order curvature terms in context of the Brans-Dicke theory of gravity, and investigate the effects of these terms on extended inflationary theories. We find that the higher-order curvature terms tend to speed up inflation, although the original extended-inflation solutions are stable when these terms are small. Analytical solutions are found for two extreme cases: when the higher-order curvature terms are small, and when they dominate. A conformal transformation is employed in solving the latter case, and some of the subtleties in this technique are discussed. We note that percolation is less likely to occur when the higher-order curvature terms are present. An upper bound on α is expected if we are to avoid excessive and inadequate percolation of true-vacuum bubbles

On M-theory fourfold vacua with higher curvature terms

International Nuclear Information System (INIS)

Grimm, Thomas W.; Pugh, Tom G.; Weißenbacher, Matthias

2015-01-01

We study solutions to the eleven-dimensional supergravity action, including terms quartic and cubic in the Riemann curvature, that admit an eight-dimensional compact space. The internal background is found to be a conformally Kähler manifold with vanishing first Chern class. The metric solution, however, is non-Ricci-flat even when allowing for a conformal rescaling including the warp factor. This deviation is due to the possible non-harmonicity of the third Chern-form in the leading order Ricci-flat metric. We present a systematic derivation of the background solution by solving the Killing spinor conditions including higher curvature terms. These are translated into first-order differential equations for a globally defined real two-form and complex four-form on the fourfold. We comment on the supersymmetry properties of the described solutions

On the gravitational seesaw in higher-derivative gravity

Energy Technology Data Exchange (ETDEWEB)

Accioly, Antonio; Giacchini, Breno L. [Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro, RJ (Brazil); Shapiro, Ilya L. [Universidade Federal de Juiz de Fora, Departamento de Fisica, ICE, Juiz de Fora, MG (Brazil); Tomsk State Pedagogical University, Tomsk (Russian Federation); Tomsk State University, Tomsk (Russian Federation)

2017-08-15

Local gravitational theories with more than four derivatives are superrenormalizable. They also may be unitary in the Lee-Wick sense. Thus it is relevant to study the low-energy properties of these theories, especially to identify observables which might be useful for experimental detection of higher derivatives. Using an analogy with the neutrino physics, we explore the possibility of a gravitational seesaw mechanism in which several dimensional parameters of the same order of magnitude produce a hierarchy in the masses of propagating particles. Such a mechanism could make a relatively light degree of freedom detectable in low-energy laboratory and astrophysical observations, such as torsion-balance experiments and the bending of light. We demonstrate that such a seesaw mechanism in the six- and more-derivative theories is unable to reduce the lightest mass more than in the simplest four-derivative model. Adding more derivatives to the four-derivative action of gravity makes heavier masses even greater, while the lightest massive ghost is not strongly affected. This fact is favorable for protecting the theory from instabilities but makes the experimental detection of higher derivatives more difficult. (orig.)

On the origin of higher braces and higher-order derivations

Czech Academy of Sciences Publication Activity Database

Markl, Martin

2015-01-01

Roč. 10, č. 3 (2015), s. 637-667 ISSN 2193-8407 Institutional support: RVO:67985840 Keywords : Koszul braces * Börjeseon braces * higher-order derivation Subject RIV: BA - General Mathematics Impact factor: 0.600, year: 2015 http://link.springer.com/article/10.1007/s40062-014-0079-2

Beyond velocity and acceleration: jerk, snap and higher derivatives

Science.gov (United States)

Eager, David; Pendrill, Ann-Marie; Reistad, Nina

2016-11-01

The higher derivatives of motion are rarely discussed in the teaching of classical mechanics of rigid bodies; nevertheless, we experience the effect not only of acceleration, but also of jerk and snap. In this paper we will discuss the third and higher order derivatives of displacement with respect to time, using the trampolines and theme park roller coasters to illustrate this concept. We will also discuss the effects on the human body of different types of acceleration, jerk, snap and higher derivatives, and how they can be used in physics education to further enhance the learning and thus the understanding of classical mechanics concepts.

A higher derivative view of the arc length and area actions

International Nuclear Information System (INIS)

Zoller, D.

1991-01-01

Higher derivative versions of the arc length and area actions are presented. The higher derivative theories are equivalent with the corresponding lower derivative theories in absence of interactions. The extra degrees of freedom associated with the higher derivatives are pure gauge due to a hidden reparametrization invariance these theories possess. The extra degrees of freedom are no longer pure gauge in the presence of background fields and the equivalence no longer holds. A string version of Wigner's continuous spin particle is also noted

Particle production in higher derivative theory

Indian Academy of Sciences (India)

Cosmological models; particle production; higher derivative theory of gravitation. PACS No. 98.80. 1. ... is of singular models where the cosmic expansion is driven by the big-bang impulse; all ... According to Gibbs integrability condition, one cannot independently specify an equa- .... [3] B Hartle and S W Hawking Phys. Rev.

Generalized Lee-Wick formulation from higher derivative field theories

International Nuclear Information System (INIS)

Cho, Inyong; Kwon, O-Kab

2010-01-01

We study a higher derivative (HD) field theory with an arbitrary order of derivative for a real scalar field. The degree of freedom for the HD field can be converted to multiple fields with canonical kinetic terms up to the overall sign. The Lagrangian describing the dynamics of the multiple fields is known as the Lee-Wick (LW) form. The first step to obtain the LW form for a given HD Lagrangian is to find an auxiliary field (AF) Lagrangian which is equivalent to the original HD Lagrangian up to the quantum level. Until now, the AF Lagrangian has been studied only for N=2 and 3 cases, where N is the number of poles of the two-point function of the HD scalar field. We construct the AF Lagrangian for arbitrary N. By the linear combinations of AF fields, we also obtain the corresponding LW form. We find the explicit mapping matrices among the HD fields, the AF fields, and the LW fields. As an exercise of our construction, we calculate the relations among parameters and mapping matrices for N=2, 3, and 4 cases.

Metric-affine formalism of higher derivative scalar fields in cosmology

International Nuclear Information System (INIS)

Li, Mingzhe; Wang, Xiulian

2012-01-01

Higher derivative scalar field theories have received considerable attention for the potentially explanations of the initial state of the universe or the current cosmic acceleration which they might offer. They have also attracted many interests in the phenomenological studies of infrared modifications of gravity. These theories are mostly studied by the metric variational approach in which only the metric is the fundamental field to account for the gravitation. In this paper we study the higher derivative scalar fields with the metric-affine formalism where the affine connection is treated arbitrarily at the beginning. Because the higher derivative scalar fields couple to the connection directly in a covariant theory these two formalisms will lead to different results. These differences are suppressed by the powers of the Planck mass and are usually expected to have small effects. But in some cases they may cause non-negligible deviations. We show by a higher derivative dark energy model that the two formalisms lead to significantly different pictures of the future universe

Classical gravity with higher derivatives

International Nuclear Information System (INIS)

Stelle, K.S.

1978-01-01

Inclusion of the four-derivative terms ∫Rsub(μν) Rsup(μν)(-g)sup(1/2) and ∫R 2 (-g)sup(1/2) into the gravitational action gives a class of effectively multimass models of gravity. In addition to the usual massless excitations of the field, there are now, for general amounts of the two new terms, massive spin-two and massive scalar excitations, with a total of eight degrees of freedom. The massive spin-two part of the field has negative energy. Specific ration of the two new terms give models with either the massive tensor or the massive scalar missing, with correspondingly fewer degrees of freedom. The static, linearized solutions of the field equations are combinations of Newtonian and Yukawa potentials. Owing to the Yukawa form of the corrections, observational evidence sets only very weak restrictions on the new masses. The acceptable static metric solutions in the full nonlinear theory are regular at the origin. The dynamical content of the linearized field is analyzed by reducing the fourth-order field equations to separated second-order equations, related by coupling to external sources in a fixed ratio. This analysis is carried out into the various helicity components using the transverse-traceless decomposition of the metric. (author)

Supersymmetric higher derivative couplings and their applications

NARCIS (Netherlands)

Lodato, I.

2014-01-01

After an elementary introduction on black hole physics, supersymmetry and effective theories, which motivates the importance of higher derivative couplings in supergravity, we give an exhaustive treatment of the covariant phase space formalism with many examples explicitly worked out. This sets the

Improved effective potential in curved spacetime and quantum matter--higher derivative gravity theory

International Nuclear Information System (INIS)

Elizalde, E.; Odintsov, S.D.; Romeo, A.

1995-01-01

We develop a general formalism to study the renormalization-group- (RG-)improved effective potential for renormalizable gauge theories, including matter-R 2 -gravity, in curved spacetime. The result is given up to quadratic terms in curvature, and one-loop effective potentials may be easily obtained from it. As an example, we consider scalar QED, where dimensional transmutation in curved space and the phase structure of the potential (in particular, curvature-induced phase transitions) are discussed. For scalar QED with higher-derivative quantum gravity (QG), we examine the influence of QG on dimensional transmutation and calculate QG corrections to the scalar-to-vector mass ratio. The phase structure of the RG-improved effective potential is also studied in this case, and the values of the induced Newton and cosmological coupling constants at the critical point are estimated. The stability of the running scalar coupling in the Yukawa theory with conformally invariant higher-derivative QG, and in the standard model with the same addition, is numerically analyzed. We show that, in these models, QG tends to make the scalar sector less unstable

Regularization with higher covariant derivatives, anomalies and the Adler-Bardeen theorem

International Nuclear Information System (INIS)

Day, M.

1983-01-01

Complications arising in the renormalization of a theory regulated by the method of higher covariant derivatives supplemented with a modified Pauli-Villars regularization are discussed. The proof of the Adler-Bardeen theorem using the method of higher covariant derivatives has to be modified. (orig.)

Scalar fields and higher-derivative gravity in brane worlds

International Nuclear Information System (INIS)

Pichler, S.

2004-01-01

We consider the brane world picture in the context of higher-derivative theories of gravity and tackle the problematic issues fine-tuning and brane-embedding. First, we give an overview of extra-dimensional physics, from the Kaluza-Klein picture up to modern brane worlds with large extra dimensions. We describe the different models and their physical impact on future experiments. We work within the framework of Randall-Sundrum models in which the brane is a gravitating object, which warps the background metric. We add scalar fields to the original model and find new and self-consistent solutions for quadratic potentials of the fields. This gives us the tools to investigate higher-derivative gravity theories in brane world models. Specifically, we take gravitational Lagrangians that depend on an arbitrary function of the Ricci scalar only, so-called f(R)-gravity. We make use of the conformal equivalence between f(R)-gravity and Einstein-Hilbert gravity with an auxiliary scalar field. We find that the solutions in the higher-derivative gravity framework behave very differently from the original Randall-Sundrum model: the metric functions do not have the typical kink across the brane. Furthermore, we present solutions that do not rely on a cosmological constant in the bulk and so avoid the fine-tuning problem. We address the issue of brane-embedding, which is important in perturbative analyses. We consider the embedding of codimension one hypersurfaces in general and derive a new equation of motion with which the choice for the embedding has to comply. In particular, this allows for a consistent consideration of brane world perturbations in the case of higher-derivative gravity. We use the newly found background solutions for quadratic potentials and find that gravity is still effectively localized on the brane, i.e that the Newtonian limit holds

Stability analysis solutions and optical solitons in extended nonlinear Schrödinger equation with higher-order odd and even terms

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Peng, Wei-Qi; Tian, Shou-Fu; Zou, Li; Zhang, Tian-Tian

2018-01-01

In this paper, the extended nonlinear Schrödinger equation with higher-order odd (third order) and even (fourth order) terms is investigated, whose particular cases are the Hirota equation, the Sasa-Satsuma equation and Lakshmanan-Porsezian-Daniel equation by selecting some specific values on the parameters of higher-order terms. We first study the stability analysis of the equation. Then, using the ansatz method, we derive its bright, dark solitons and some constraint conditions which can guarantee the existence of solitons. Moreover, the Ricatti equation extension method is employed to derive some exact singular solutions. The outstanding characteristics of these solitons are analyzed via several diverting graphics.

Quantum fluctuations and thermal dissipation in higher derivative gravity

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Dibakar Roychowdhury

2015-08-01

Full Text Available In this paper, based on the AdS2/CFT1 prescription, we explore the low frequency behavior of quantum two point functions for a special class of strongly coupled CFTs in one dimension whose dual gravitational counterpart consists of extremal black hole solutions in higher derivative theories of gravity defined over an asymptotically AdS spacetime. The quantum critical points thus described are supposed to correspond to a very large value of the dynamic exponent (z→∞. In our analysis, we find that quantum fluctuations are enhanced due to the higher derivative corrections in the bulk which in turn increases the possibility of quantum phase transition near the critical point. On the field theory side, such higher derivative effects would stand for the corrections appearing due to the finite coupling in the gauge theory. Finally, we compute the coefficient of thermal diffusion at finite coupling corresponding to Gauss Bonnet corrected charged Lifshitz black holes in the bulk. We observe an important crossover corresponding to z=5 fixed point.

From M-theory higher curvature terms to α′ corrections in F-theory

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Thomas W. Grimm

2016-02-01

Full Text Available We perform a Kaluza–Klein reduction of eleven-dimensional supergravity on a Calabi–Yau fourfold including terms quartic and cubic in the Riemann curvature and determine the induced corrections to the three-dimensional two-derivative N=2 effective action. We focus on the effective Einstein–Hilbert term and the kinetic terms for vectors. Dualizing the vectors into scalars, we derive the resulting Kähler potential and complex coordinates. The classical expressions for the Kähler coordinates are non-trivially modified by terms containing the third Chern form of the background Calabi–Yau fourfold, while the functional form of the Kähler potential is shown to be uncorrected. We omit terms proportional to the non-harmonic part of the third Chern form. For elliptically fibered Calabi–Yau fourfolds the corrections can be uplifted to a four-dimensional F-theory compactification. We argue that also the four-dimensional N=1 Kähler coordinates receive non-trivial corrections. We find a simple expression for the induced corrections for different Abelian and non-Abelian seven-brane configurations by scanning over many Calabi–Yau fourfolds with resolved singularities. The interpretation of this expression leads us to conjecture that the higher-curvature corrections correspond to α′2 corrections that arise from open strings at the self-intersection of seven-branes.

A relation between deformed superspace and Lee-Wick higher-derivative theories

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Dias, M.; Ferrari, A. F.; Palechor, C. A.; Senise, C. R., Jr.

2015-07-01

We propose a non-anticommutative superspace that relates to the Lee-Wick type of higher-derivative theories, which are known for their interesting properties and have led to proposals of phenomenologically viable higher-derivative extensions of the Standard Model. The deformation of superspace we consider does not preserve supersymmetry or associativity in general, but, we show that a non-anticommutative version of the Wess-Zumino model can be properly defined. In fact, the definition of chiral and antichiral superfields turns out to be simpler in our case than in the well known N=1/2 supersymmetric case. We show that when the theory is truncated at the first nontrivial order in the deformation parameter, supersymmetry is restored, and we end up with a well-known Lee-Wick type of higher-derivative extension of the Wess-Zumino model. Thus, we show how non-anticommutativity could provide an alternative mechanism for generating these higher-derivative theories.

One loop beta functions and fixed points in higher derivative sigma models

International Nuclear Information System (INIS)

Percacci, Roberto; Zanusso, Omar

2010-01-01

We calculate the one loop beta functions of nonlinear sigma models in four dimensions containing general two- and four-derivative terms. In the O(N) model there are four such terms and nontrivial fixed points exist for all N≥4. In the chiral SU(N) models there are in general six couplings, but only five for N=3 and four for N=2; we find fixed points only for N=2, 3. In the approximation considered, the four-derivative couplings are asymptotically free but the coupling in the two-derivative term has a nonzero limit. These results support the hypothesis that certain sigma models may be asymptotically safe.

Selfinteraction force in a theory of gravitation with higher derivatives

International Nuclear Information System (INIS)

Jankiewicz, C.

1981-01-01

Approximate equations of motion are derived from gravitational field equations with higher derivatives. The approximation takes into account the selfinteraction force. The selfinteraction force coincides with the analogous force resulting from the Einstein field equations. (author)

The Adler D-function for N = 1 SQCD regularized by higher covariant derivatives in the three-loop approximation

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Kataev, A. L.; Kazantsev, A. E.; Stepanyantz, K. V.

2018-01-01

We calculate the Adler D-function for N = 1 SQCD in the three-loop approximation using the higher covariant derivative regularization and the NSVZ-like subtraction scheme. The recently formulated all-order relation between the Adler function and the anomalous dimension of the matter superfields defined in terms of the bare coupling constant is first considered and generalized to the case of an arbitrary representation for the chiral matter superfields. The correctness of this all-order relation is explicitly verified at the three-loop level. The special renormalization scheme in which this all-order relation remains valid for the D-function and the anomalous dimension defined in terms of the renormalized coupling constant is constructed in the case of using the higher derivative regularization. The analytic expression for the Adler function for N = 1 SQCD is found in this scheme to the order O (αs2). The problem of scheme-dependence of the D-function and the NSVZ-like equation is briefly discussed.

The Adler D-function for N=1 SQCD regularized by higher covariant derivatives in the three-loop approximation

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A.L. Kataev

2018-01-01

Full Text Available We calculate the Adler D-function for N=1 SQCD in the three-loop approximation using the higher covariant derivative regularization and the NSVZ-like subtraction scheme. The recently formulated all-order relation between the Adler function and the anomalous dimension of the matter superfields defined in terms of the bare coupling constant is first considered and generalized to the case of an arbitrary representation for the chiral matter superfields. The correctness of this all-order relation is explicitly verified at the three-loop level. The special renormalization scheme in which this all-order relation remains valid for the D-function and the anomalous dimension defined in terms of the renormalized coupling constant is constructed in the case of using the higher derivative regularization. The analytic expression for the Adler function for N=1 SQCD is found in this scheme to the order O(αs2. The problem of scheme-dependence of the D-function and the NSVZ-like equation is briefly discussed.

Initial value formulation of higher derivative gravity

International Nuclear Information System (INIS)

Noakes, D.R.

1983-01-01

The initial value problem is considered for the conformally coupled scalar field and higher derivative gravity, by expressing the equations of each theory in harmonic coordinates. For each theory it is shown that the (vacuum) equations can take the form of a diagonal hyperbolic system with constraints on the initial data. Consequently these theories possess well-posed initial value formulations

Hamiltonian formulation of theory with higher order derivatives

International Nuclear Information System (INIS)

Gitman, D.M.; Lyakhovich, S.L.; Tyutin, I.V.

1983-01-01

A method of ''hamiltonization'' of a special theory with higher order derivatives is described. In a nonspecial case the result coincides with the known Ostrogradsky formulation. It is shown that in the nonspecial theory the lagrange equations of motion are reduced to the normal form

Cosmological perturbations in non-local higher-derivative gravity

International Nuclear Information System (INIS)

Craps, Ben; Jonckheere, Tim De; Koshelev, Alexey S.

2014-01-01

We study cosmological perturbations in a non-local higher-derivative model of gravity introduced by Biswas, Mazumdar and Siegel. We extend previous work, which had focused on classical scalar perturbations around a cosine hyperbolic bounce solution, in three ways. First, we point out the existence of a Starobinsky solution in this model, which is more attractive from a phenomenological point of view (even though it has no bounce). Second, we study classical vector and tensor pertuxsxrbations. Third, we show how to quantize scalar and tensor perturbations in a de Sitter phase (for choices of parameters such that the model is ghost-free). Our results show that the model is well-behaved at this level, and are very similar to corresponding results in local f(R) models. In particular, for the Starobinsky solution of non-local higher-derivative gravity, we find the same tensor-to-scalar ratio as for the conventional Starobinsky model

Higher-derivative mechanics with N = 2 l -conformal Galilei supersymmetry

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Masterov, Ivan

2015-02-01

The analysis previously developed in [J. Math. Phys. 55 102901 (2014)] is used to construct systems which hold invariant under N = 2 l -conformal Galilei superalgebra. The models describe two different supersymmetric extensions of a free higher-derivative particle. Their Newton-Hooke counterparts are derived by applying appropriate coordinate transformations.

Fivebrane instantons and higher derivative couplings in type I theory

International Nuclear Information System (INIS)

Hammou, Amine B.; Morales, Jose F.

2000-01-01

We express the infinite sum of D5-brane instanton corrections to R 2 couplings in N=4 type I string vacua, in terms of an elliptic index counting 1/2-BPS excitations in the effective Sp(N) brane theory. We compute the index explicitly in the infrared, where the effective theory is argued to flow to an orbifold CFT. The form of the instanton sum agrees completely with the predicted formula from a dual one-loop computation in type IIA theory on K3xT 2 . The proposed CFT provides a proper description of the whole spectrum of masses, charges and multiplicities for 1/2- and 1/4-BPS states, associated to bound states of D5-branes and KK momenta. These results are applied to show how fivebrane instanton sums, entering higher derivative couplings which are sensitive to 1/4-BPS contributions, also match the perturbative results in the dual type IIA theory

Canonical quantum theory of gravitational field with higher derivatives, 3

International Nuclear Information System (INIS)

Kawasaki, Shoichiro; Kimura, Tadahiko

1983-01-01

A formulation which is invariant under an additional BRS transformation with nilpotency of order two is presented for the canonical theory of the renormalizable quantum gravity with higher derivatives. The canonical quantization is carried out and various equal time (anti-) commutation relations are derived. The asymptotic fields are reanalyzed. The physical particle contents are just the same as those obtained in previous papers. (author)

Stability in higher-derivative matter fields theories

International Nuclear Information System (INIS)

Tretyakov, Petr V.

2016-01-01

We discuss possible instabilities in higher-derivative matter field theories. These theories have two free parameters β 1 and β 4 . By using a dynamical system approach we explicitly demonstrate that for the stability of Minkowski space in an expanding universe we need the condition β 4 < 0. By using the quantum field theory approach we also find an additional restriction for the parameters, β 1 > -(1)/(3)β 4 , which is needed to avoid a tachyon-like instability. (orig.)

Classical and quantum-mechanical axioms with the higher time derivative formalism

International Nuclear Information System (INIS)

Kamalov, Timur

2013-01-01

A Newtonian mechanics model is essentially the model of a point body in an inertial reference frame. How to describe extended bodies in non-inertial (vibration) reference frames with the random initial conditions? One of the most generalized ways of descriptions (known as the higher derivatives formalism) consists in taking into account the infinite number of the higher temporal derivatives of the coordinates in the Lagrange function. Such formalism describing physical objects in the infinite dimensions space does not contradict to the quantum mechanics and infinite dimensions Hilbert space.

Lifting Term Rewriting Derivations in Constructor Systems by Using Generators

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Adrián Riesco

2015-01-01

Full Text Available Narrowing is a procedure that was first studied in the context of equational E-unification and that has been used in a wide range of applications. The classic completeness result due to Hullot states that any term rewriting derivation starting from an instance of an expression can be "lifted" to a narrowing derivation, whenever the substitution employed is normalized. In this paper we adapt the generator- based extra-variables-elimination transformation used in functional-logic programming to overcome that limitation, so we are able to lift term rewriting derivations starting from arbitrary instances of expressions. The proposed technique is limited to left-linear constructor systems and to derivations reaching a ground expression. We also present a Maude-based implementation of the technique, using natural rewriting for the on-demand evaluation strategy.

Dimensional reduction of 10d heterotic string effective lagrangian with higher derivative terms

International Nuclear Information System (INIS)

Lalak, Z.; Pawelczyk, J.

1989-11-01

Dimensional reduction of the 10d Supergravity-Yang-Mills theories containing up to four derivatives is described. Unexpected nondiagonal corrections to 4d gauge kinetic function and negative contributions to scalar potential are found. We analyzed the general structure of the resulting lagrangian and discuss the possible phenomenological consequences. (author)

A hierarchical generalization of the acoustic reciprocity theorem involving higher-order derivatives and interaction quantities.

Science.gov (United States)

Lin, Ju; Li, Jie; Li, Xiaolei; Wang, Ning

2016-10-01

An acoustic reciprocity theorem is generalized, for a smoothly varying perturbed medium, to a hierarchy of reciprocity theorems including higher-order derivatives of acoustic fields. The standard reciprocity theorem is the first member of the hierarchy. It is shown that the conservation of higher-order interaction quantities is related closely to higher-order derivative distributions of perturbed media. Then integral reciprocity theorems are obtained by applying Gauss's divergence theorem, which give explicit integral representations connecting higher-order interactions and higher-order derivative distributions of perturbed media. Some possible applications to an inverse problem are also discussed.

Asymptotic safety of higher derivative quantum gravity non-minimally coupled with a matter system

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Hamada, Yuta; Yamada, Masatoshi

2017-08-01

We study asymptotic safety of models of the higher derivative quantum gravity with and without matter. The beta functions are derived by utilizing the functional renormalization group, and non-trivial fixed points are found. It turns out that all couplings in gravity sector, namely the cosmological constant, the Newton constant, and the R 2 and R μν 2 coupling constants, are relevant in case of higher derivative pure gravity. For the Higgs-Yukawa model non-minimal coupled with higher derivative gravity, we find a stable fixed point at which the scalar-quartic and the Yukawa coupling constants become relevant. The relevant Yukawa coupling is crucial to realize the finite value of the Yukawa coupling constants in the standard model.

Higher-derivative boson field theories and constrained second-order theories

Energy Technology Data Exchange (ETDEWEB)

Urries, F.J. de [Departamento de Fisica, Universidad de Alcala de Henares, Madrid (Spain) and IMAFF, Consejo Superior de Investigaciones Cientificas, Madrid (Spain)]. E-mail: fernando.urries@uah.es; Julve, J. [IMAFF, Consejo Superior de Investigaciones Cientificas, Madrid (Spain)]. E-mail: julve@imaff.cfmac.csic.es; Sanchez, E.J. [IMAFF, Consejo Superior de Investigaciones Cientificas, Madrid (ES) and Departamento de Matematica, Universidad Europea, Madrid (Spain)]. E-mail: ejesus.sanchez@mat.ind.uem.es

2001-10-26

As an alternative to the covariant Ostrogradski method, we show that higher-derivative (HD) relativistic Lagrangian field theories can be reduced to second differential order by writing them directly as covariant two-derivative theories involving Lagrange multipliers and new fields. Despite the intrinsic non-covariance of the Dirac procedure used to deal with the constraints, the explicit Lorentz invariance is recovered at the end. We develop this new setting on the basis of a simple scalar model and then its applications to generalized electrodynamics and HD gravity are worked out. For a wide class of field theories this method is better suited than Ostrogradski's for a generalization to 2n-derivative theories. (author)

Quantum Noether identities for non-local transformations in higher-order derivatives theories

International Nuclear Information System (INIS)

Li, Z.P.; Long, Z.W.

2003-01-01

Based on the phase-space generating functional of the Green function for a system with a regular/singular higher-order Lagrangian, the quantum canonical Noether identities (NIs) under a local and non-local transformation in phase space have been deduced, respectively. For a singular higher-order Lagrangian, one must use an effective canonical action I eff P in quantum canonical NIs instead of the classical I P in classical canonical NIs. The quantum NIs under a local and non-local transformation in configuration space for a gauge-invariant system with a higher-order Lagrangian have also been derived. The above results hold true whether or not the Jacobian of the transformation is equal to unity or not. It has been pointed out that in certain cases the quantum NIs may be converted to conservation laws at the quantum level. This algorithm to derive the quantum conservation laws is significantly different from the quantum first Noether theorem. The applications of our formulation to the Yang-Mills fields and non-Abelian Chern-Simons (CS) theories with higher-order derivatives are given, and the conserved quantities at the quantum level for local and non-local transformations are found, respectively. (orig.)

Cosmological and black hole brane-world universes in higher derivative gravity

International Nuclear Information System (INIS)

Nojiri, Shin'ichi; Odintsov, Sergei D.; Ogushi, Sachiko

2002-01-01

A general model of multidimensional R 2 gravity including a Riemann tensor square term (nonzero c case) is considered. The number of brane-worlds in such a model is constructed (mainly in five dimensions) and their properties are discussed. The thermodynamics of a Schwarzschild-anti-deSitter (S-AdS) BH (with boundary) is presented when perturbation on c is used. The entropy, free energy, and energy are calculated. For a nonzero c the entropy (energy) is not proportional to the area (mass). The equation of motion of the brane in a BH background is presented as a FRW equation. Using a dual CFT description it is shown that the dual field theory is not a conformal one when c is not zero. In this case the holographic entropy does not coincide with the BH entropy (they coincide for Einstein gravity or c=0 HD gravity where the AdS/CFT description is well applied). An asymmetrically warped background (an analogue of a charged AdS BH) where Lorentz invariance violation occurs is found. The cosmological 4D dS brane connecting two dS bulk spaces is formulated in terms of the parameters of R 2 gravity. Within the proposed dS/CFT correspondence the holographic conformal anomaly from five-dimensional higher derivative gravity in a de Sitter background is evaluated

Ambulatory blood pressure monitoring-derived short-term blood pressure variability is increased in Cushing's syndrome.

Science.gov (United States)

Rebellato, Andrea; Grillo, Andrea; Dassie, Francesca; Sonino, Nicoletta; Maffei, Pietro; Martini, Chiara; Paoletta, Agostino; Fabris, Bruno; Carretta, Renzo; Fallo, Francesco

2014-11-01

Cushing's syndrome is associated with high cardiovascular morbility and mortality. Blood pressure (BP) variability within a 24-h period is increasingly recognized as an independent predictor of cardiovascular risk. The aim of our study was to investigate the short-term BP variability indices in Cushing's syndrome. Twenty-five patients with Cushing's syndrome (mean age 49 ± 13 years, 4 males; 21 Cushing's disease and 4 adrenal adenoma patients) underwent 24-h ambulatory BP monitoring (ABPM) and evaluation of cardiovascular risk factors. Cushing patients were divided into 8 normotensive (NOR-CUSH) and 17 hypertensive (HYP-CUSH) patients and were compared with 20 normotensive (NOR-CTR) and 20 hypertensive (HYP-CTR) age-, sex-, and BMI-matched control subjects. Short-term BP variability was derived from ABPM and calculated as the following: (1) standard deviation (SD) of 24-h, daytime, and nighttime BP; (2) 24-h weighted SD of BP; and (3) average real variability (ARV), i.e., the average of the absolute differences between consecutive BP measurements over 24 h. In comparison with controls, patients with Cushing's syndrome, either normotensive or hypertensive, had higher 24-h and daytime SD of BP, as well as higher 24-h weighted SD and ARV of BP (P = 0.03 to P CUSH or between HYP-CTR and HYP-CUSH subgroups. ABPM-derived short-term BP variability is increased in Cushing's syndrome, independent of BP elevation. It may represent an additional cardiovascular risk factor in this disease. The role of excess cortisol in BP variability has to be further clarified.

An unusual cosmological solution in the context of higher-derivative gravity

International Nuclear Information System (INIS)

Accioly, A.J.

1988-01-01

A general vacuum solution to the higher-derivative gravity field equations is presented in case of a model that exhibits symmetries of the Goedel-type. The solution possesses unusual properties. (author) [pt

EVH black hole solutions with higher derivative corrections

International Nuclear Information System (INIS)

Yavartanoo, Hossein

2012-01-01

We analyze the effect of higher derivative corrections to the near horizon geometry of the extremal vanishing horizon (EVH) black hole solutions in four dimensions. We restrict ourselves to a Gauss-Bonnet correction with a dilation dependent coupling in an Einstein-Maxwell-dilaton theory. This action may represent the effective action as it arises in tree level heterotic string theory compactified to four dimensions or the K3 compactification of type II string theory. We show that EVH black holes, in this theory, develop an AdS 3 throat in their near horizon geometry. (orig.)

Can the causal pathologies of Goedel-type universes be avoided in higher-derivative gravity

International Nuclear Information System (INIS)

Accioly, A.J.; Goncalves, A.T.

1986-10-01

A completely causal rotating Goedel-type universe is obtained in the context of higher-derivative gravity. The solution is such that it has no similar in the framework of standard general relativity. The aforementioned solution presents the interesting feature of relating the mass of the nontachyonic spin-O particle, concerning the linearized higher-derivative theory, with the velocity of rigid rotation of matter. (Author) [pt

Higher order alchemical derivatives from coupled perturbed self-consistent field theory.

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Lesiuk, Michał; Balawender, Robert; Zachara, Janusz

2012-01-21

We present an analytical approach to treat higher order derivatives of Hartree-Fock (HF) and Kohn-Sham (KS) density functional theory energy in the Born-Oppenheimer approximation with respect to the nuclear charge distribution (so-called alchemical derivatives). Modified coupled perturbed self-consistent field theory is used to calculate molecular systems response to the applied perturbation. Working equations for the second and the third derivatives of HF/KS energy are derived. Similarly, analytical forms of the first and second derivatives of orbital energies are reported. The second derivative of Kohn-Sham energy and up to the third derivative of Hartree-Fock energy with respect to the nuclear charge distribution were calculated. Some issues of practical calculations, in particular the dependence of the basis set and Becke weighting functions on the perturbation, are considered. For selected series of isoelectronic molecules values of available alchemical derivatives were computed and Taylor series expansion was used to predict energies of the "surrounding" molecules. Predicted values of energies are in unexpectedly good agreement with the ones computed using HF/KS methods. Presented method allows one to predict orbital energies with the error less than 1% or even smaller for valence orbitals. © 2012 American Institute of Physics

Renormalization of supersymmetric gauge theories on orbifolds: Brane gauge couplings and higher derivative operators

International Nuclear Information System (INIS)

Groot Nibbelink, Stefan; Hillenbach, Mark

2005-01-01

We consider supersymmetric gauge theories coupled to hypermultiplets on five- and six-dimensional orbifolds and determine the bulk and local fixed point renormalizations of the gauge couplings. We infer from a component analysis that the hypermultiplet does not induce renormalization of the brane gauge couplings on the five-dimensional orbifold S 1 /Z 2 . This is not due to supersymmetry, since the bosonic and fermionic contributions cancel separately. We extend this investigation to T 2 /Z N orbifolds using supergraph techniques in six dimensions. On general Z N orbifolds the gauge couplings do renormalize at the fixed points, except for the Z 2 fixed points of even ordered orbifolds. To cancel the bulk one-loop divergences a dimension six higher derivative operator is needed, in addition to the standard bulk gauge kinetic term.

Canonical quantum theory of gravitational field with higher derivatives

International Nuclear Information System (INIS)

Kawasaki, Shoichiro; Kimura, Tadahiko; Kitago, Koichi.

1981-01-01

A renormalizable gravitational theory with higher derivatives is canonically quantized in the Landau gauge. Field equations and various equal-time commutation relations are explicitly given. The main results obtained in this work are 1) the equal-time commutation relations involving b sub(μ) exhibit the tensor-like behaviour and 2) the theory has the 16-dimensional Poincare-like superalgebra. These results are just the same as those discovered by Nakanishi in the Einstein case. (author)

Newer methods for the characterization of higher molecular mass coal derivatives

International Nuclear Information System (INIS)

Bartle, K.D.

1983-01-01

Recent developments in a number of areas in the analytical chemistry of higher molecular mass coal derivatives are critically reviewed, viz. supercritical fluid chromatography, size-exclusion chromatography, charge-transfer fractionation, nmr spectroscopy, mass spectrometry and electrochemical analysis. (orig.) [de

Scalar potential from higher derivative N=1 superspace

International Nuclear Information System (INIS)

Ciupke, David

2016-05-01

The supersymmetric completion of higher-derivative operators often requires introducing corrections to the scalar potential. In this paper we study these corrections systematically in the context of theories with N=1 global and local supersymmetry in D=4 focusing on ungauged chiral multiplets. In globally supersymmetric theories the most general off-shell effective scalar potential can be captured by a dependence of the Kaehler potential on additional chiral superfields. For supergravity we find a much richer structure of possible corrections. In this context we classify the leading order and next-to-leading order superspace derivative operators and determine the component forms of a subclass thereof. Moreover, we present an algorithm that simplifies the computation of the respective on-shell action. As particular applications we study the structure of the supersymmetric vacua for these theories and comment on the form of the corrections to shift-symmetric no-scale models. These results are relevant for the computation of effective actions for string compactifications and, in turn, for moduli stabilization and string inflation.

Higher order terms of the nonlinear forces in plasmas with collisions at laser interaction

International Nuclear Information System (INIS)

Kentwell, G.W.; Hora, H.

1980-01-01

The evaluation of the general expression of the nonlinear force of laser-plasma interaction showed discrepancies depending on the assumptions of the phase and collisions in the expressions used for E and H. While the first order terms of the derivations are remaining unchanged, new third order terms are found for the case of perpendicular incidence without collisions. With collisions, the additional non-pondermotive terms are derived to be more general than known before. It is then possible to evaluate the forces for oblique incidence with collisions and find an absorption caused force in the plane of the plasma surface. (author)

Hamilton-Jacobi approach for first order actions and theories with higher derivatives

International Nuclear Information System (INIS)

Bertin, M.C.; Pimentel, B.M.; Pompeia, P.J.

2008-01-01

In this work, we analyze systems described by Lagrangians with higher order derivatives in the context of the Hamilton-Jacobi formalism for first order actions. Two different approaches are studied here: the first one is analogous to the description of theories with higher derivatives in the hamiltonian formalism according to [D.M. Gitman, S.L. Lyakhovich, I.V. Tyutin, Soviet Phys. J. 26 (1983) 730; D.M. Gitman, I.V. Tyutin, Quantization of Fields with Constraints, Springer-Verlag, New York, Berlin, 1990] the second treats the case where degenerate coordinate are present, in an analogy to reference [D.M. Gitman, I.V. Tyutin, Nucl. Phys. B 630 (2002) 509]. Several examples are analyzed where a comparison between both approaches is made

Canonical quantum theory of gravitational field with higher derivatives, 2

International Nuclear Information System (INIS)

Kawasaki, Shoichiro; Kimura, Tadahiko

1982-01-01

The asymptotic fields in a canonically quantized graviational field with higher derivatives are analyzed. A possible mechanism of the recovery of the physical S-matrix unitarity is discussed. The constraint nabla sub(μ)(B sup(μν) + (Beta /α)g sup(μν)B) = 0 due to the Bianchi identity on R sub(μν) is treated by Dirac's method. (author)

Entanglement of higher-derivative oscillators in holographic systems

Energy Technology Data Exchange (ETDEWEB)

Dimov, Hristo, E-mail: h_dimov@phys.uni-sofia.bg [Department of Physics, Sofia University, 5 J. Bourchier Blvd., 1164 Sofia (Bulgaria); Mladenov, Stefan, E-mail: smladenov@phys.uni-sofia.bg [Department of Physics, Sofia University, 5 J. Bourchier Blvd., 1164 Sofia (Bulgaria); Rashkov, Radoslav C., E-mail: rash@phys.uni-sofia.bg [Department of Physics, Sofia University, 5 J. Bourchier Blvd., 1164 Sofia (Bulgaria); Institute for Theoretical Physics, Vienna University of Technology, Wiedner Hauptstr. 8–10, 1040 Vienna (Austria); Vetsov, Tsvetan, E-mail: vetsov@phys.uni-sofia.bg [Department of Physics, Sofia University, 5 J. Bourchier Blvd., 1164 Sofia (Bulgaria)

2017-05-15

We study the quantum entanglement of coupled Pais–Uhlenbeck oscillators using the formalism of thermo-field dynamics. The entanglement entropy is computed for the specific cases of two and a ring of N coupled Pais–Uhlenbeck oscillators of fourth order. It is shown that the entanglement entropy depends on the temperatures, frequencies and coupling parameters of the different degrees of freedom corresponding to harmonic oscillators. We also make remarks on the appearance of instabilities of higher-derivative oscillators in the context of AdS/CFT correspondence. Finally, we advert to the information geometry theory by calculating the Fisher information metric for the considered system of coupled oscillators.

Higher education academics' satisfaction with their terms and ...

African Journals Online (AJOL)

Higher education academics' satisfaction with their terms and conditions of service and their job satisfaction: A case study. ... The freezing of salary increases which resulted in academics' effective income (due to inflation) being less than that in 1995 was identified as the major cause of dissatisfaction with the conditions of ...

α{sup '} inflation. Moduli stabilisation and observable tensors from higher derivatives

Energy Technology Data Exchange (ETDEWEB)

Cicoli, Michele [Bologna Univ. (Italy). Dipt. di Fisica ed Astronomia; INFN, Sezione di Bologna (Italy); Abdus Salam International Centre for Theoretical Physics, Trieste (Italy); Ciupke, David [DESY, Hamburg (Germany). Theory Group; De Alwis, Senarath [Colorado Univ., Boulder, CO (United States). Dept. of Physics; Muia, Francesco [INFN, Sezione di Bologna (Italy)

2016-07-15

The leading order dynamics of the type IIB Large Volume Scenario is characterised by the interplay between α{sup '} and non-perturbative effects which fix the overall volume and all local blow-up modes leaving (in general) several flat directions. In this paper we show that, in an arbitrary Calabi-Yau with at least one blow-up mode resolving a point-like singularity, any remaining flat directions can be lifted at subleading order by the inclusions of higher derivative α{sup '} corrections. We then focus on simple fibred cases with one remaining flat direction which can behave as an inflaton if its potential is generated by both higher derivative α{sup '} and winding loop corrections. Natural values of the underlying parameters give a spectral index in agreement with observational data and a tensor-to-scalar ratio of order r=0.01 which could be observed by forthcoming CMB experiments. Dangerous corrections from higher dimensional operators are suppressed due to the presence of an approximate non-compact shift symmetry.

Extended higher-spin superalgebras and their realizations in terms of quantum operators

Energy Technology Data Exchange (ETDEWEB)

Vasiliev, M A

1988-01-01

The realization of the N = 1 higher-spin superalgebra, proposed earlier by E.S. Fradkin and the author, is found in terms of bosonic quantum operators. The extended higher-spin superalgebras, generalizing ordinary extended supersymmetry with arbitrary N > 1, are constructed by adding fermion quantum operators. Automorphisms, real forms, subalgebras, contractions and invariant forms of these infinite-dimensional superalgebras are studied. The formulation of the higher-spin superalgebras is described in terms of symbols of operators by Berezin. We hope that this formulation will provide in future the powerful tool for constructing the complete solution of the higher-spin problem, the problem of introducing a consistent gravitational interaction for massless higher-spin fields (s > 2).

Higher derivative analysis for the interpretation of self-potential profiles at southern part of the Nile Delta, Egypt

International Nuclear Information System (INIS)

Hafez, M.; EL-Qady, G.; Awad, S.; Elsayed, E.

2006-01-01

One of the most important, but also one of the most tedious, problems confronting the mineral industries in dealing with the sulfides and graphite is estimating the depth of a buried object from self-potential anomalies. A peat layer has been encountered in the subsurface Holocene sediments of the eastern part of the Nile Delta at depths range from 7 to 13 meters. The maximum thickness of the peat (3m) has been recorded in the southern part of the Mansoura city and it decreases gradually in a configuration parallel to Damietta branch of the Nile. To elucidate the peat layer in terms of depth and thickness, a self-potential survey was carried at Mansoura city, Nile Delta of Egypt, in terms of eight profiles. Interpretation of data was performed through the correction and processing using the derivative analysis of higher orders by means of an algorithm developed by the authors. Depth, shape factor and the optimum order of the regional components are determined. A rough estimation of the relief of the peat layer was derived. Based in the results, the depth to the peat layer varies from 11.8 up to 13.1 meters which correlates very well with the available information and the lithological data in the area. (author)

Lovelock terms and BRST cohomology

International Nuclear Information System (INIS)

Cnockaert, Sandrine; Henneaux, Marc

2005-01-01

Lovelock terms are polynomial scalar densities in the Riemann curvature tensor that have the remarkable property that their Euler-Lagrange derivatives contain derivatives of the metric of an order not higher than 2 (while generic polynomial scalar densities lead to Euler-Lagrange derivatives with derivatives of the metric of order 4). A characteristic feature of Lovelock terms is that their first nonvanishing term in the expansion g λμ = η λμ + h λμ of the metric around flat space is a total derivative. In this paper, we investigate generalized Lovelock terms defined as polynomial scalar densities in the Riemann curvature tensor and its covariant derivatives (of arbitrarily high but finite order) such that their first nonvanishing term in the expansion of the metric around flat space is a total derivative. This is done by reformulating the problem as a BRST cohomological one and by using cohomological tools. We determine all the generalized Lovelock terms. We find, in fact, that the class of nontrivial generalized Lovelock terms contains only the usual ones. Allowing covariant derivatives of the Riemann tensor does not lead to a new structure. Our work provides a novel algebraic understanding of the Lovelock terms in the context of BRST cohomology

A novel derivation of the boundary term for the action in Lanczos-Lovelock gravity

Science.gov (United States)

Chakraborty, Sumanta; Parattu, Krishnamohan; Padmanabhan, T.

2017-09-01

We present a novel derivation of the boundary term for the action in Lanczos-Lovelock gravity, starting from the boundary contribution in the variation of the Lanczos-Lovelock action. The derivation presented here is straightforward, i.e., one starts from the Lanczos-Lovelock action principle and the action itself dictates the boundary structure and hence the boundary term one needs to add to the action to make it well-posed. It also gives the full structure of the contribution at the boundary of the complete action, enabling us to read off the degrees of freedom to be fixed at the boundary, their corresponding conjugate momenta and the total derivative contribution on the boundary. We also provide a separate derivation of the Gauss-Bonnet case.

Perturbative reduction of derivative order in EFT

Science.gov (United States)

Glavan, Dražen

2018-02-01

Higher derivative corrections are ubiquitous in effective field theories, which seemingly introduces new degrees of freedom at successive orders. This is actually an artefact of the implicit local derivative expansion defining effective field theories. We argue that higher derivative corrections that introduce additional degrees of freedom should be removed and their effects captured either by lower derivative corrections, or special combinations of higher derivative corrections not propagating extra degrees of freedom. Three methods adapted for this task are examined and field redefinitions are found to be most appropriate. First order higher derivative corrections in a scalar tensor theory are removed by field redefinition and it is found that their effects are captured by a subset of Horndeski theories. A case is made for restricting the effective field theory expansions in principle to only terms not introducing additional degrees of freedom.

Evaluating the Wald entropy from two-derivative terms in quadratic actions

International Nuclear Information System (INIS)

Brustein, Ram; Gorbonos, Dan; Hadad, Merav; Medved, A. J. M.

2011-01-01

We evaluate the Wald Noether charge entropy for a black hole in generalized theories of gravity. Expanding the Lagrangian to second order in gravitational perturbations, we show that contributions to the entropy density originate only from the coefficients of two-derivative terms. The same considerations are extended to include matter fields and to show that arbitrary powers of matter fields and their symmetrized covariant derivatives cannot contribute to the entropy density. We also explain how to use the linearized gravitational field equation rather than quadratic actions to obtain the same results. Several explicit examples are presented that allow us to clarify subtle points in the derivation and application of our method.

Ambulatory blood pressure monitoring-derived short-term blood pressure variability in primary hyperparathyroidism.

Science.gov (United States)

Concistrè, A; Grillo, A; La Torre, G; Carretta, R; Fabris, B; Petramala, L; Marinelli, C; Rebellato, A; Fallo, F; Letizia, C

2018-04-01

Primary hyperparathyroidism is associated with a cluster of cardiovascular manifestations, including hypertension, leading to increased cardiovascular risk. The aim of our study was to investigate the ambulatory blood pressure monitoring-derived short-term blood pressure variability in patients with primary hyperparathyroidism, in comparison with patients with essential hypertension and normotensive controls. Twenty-five patients with primary hyperparathyroidism (7 normotensive,18 hypertensive) underwent ambulatory blood pressure monitoring at diagnosis, and fifteen out of them were re-evaluated after parathyroidectomy. Short-term-blood pressure variability was derived from ambulatory blood pressure monitoring and calculated as the following: 1) Standard Deviation of 24-h, day-time and night-time-BP; 2) the average of day-time and night-time-Standard Deviation, weighted for the duration of the day and night periods (24-h "weighted" Standard Deviation of BP); 3) average real variability, i.e., the average of the absolute differences between all consecutive BP measurements. Baseline data of normotensive and essential hypertension patients were matched for age, sex, BMI and 24-h ambulatory blood pressure monitoring values with normotensive and hypertensive-primary hyperparathyroidism patients, respectively. Normotensive-primary hyperparathyroidism patients showed a 24-h weighted Standard Deviation (P blood pressure higher than that of 12 normotensive controls. 24-h average real variability of systolic BP, as well as serum calcium and parathyroid hormone levels, were reduced in operated patients (P blood pressure variability is increased in normotensive patients with primary hyperparathyroidism and is reduced by parathyroidectomy, and may potentially represent an additional cardiovascular risk factor in this disease.

Two-loop finiteness of self-energies in higher-derivative SQED3

Directory of Open Access Journals (Sweden)

E.A. Gallegos

2015-09-01

Full Text Available In the N=1 superfield formalism, two higher-derivative kinetic operators (Lee–Wick operators are implemented into the standard three dimensional supersymmetric quantum electrodynamics (SQED3 for improving its ultraviolet behavior. It is shown in particular that the ghosts associated with these Lee–Wick operators allow to remove all ultraviolet divergences in the scalar and gauge self-energies at two-loop level.

The DBI action, higher-derivative supergravity, and flattening inflaton potentials

International Nuclear Information System (INIS)

Bielleman, Sjoerd; Ibáñez, Luis E.; Pedro, Francisco G.; Valenzuela, Irene; Wieck, Clemens

2016-01-01

In string theory compactifications it is common to find an effective Lagrangian for the scalar fields with a non-canonical kinetic term. We study the effective action of the scalar position moduli of Type II Dp-branes. In many instances the kinetic terms are in fact modified by a term proportional to the scalar potential itself. This can be linked to the appearance of higher-dimensional supersymmetric operators correcting the Kähler potential. We identify the supersymmetric dimension-eight operators describing the α"′ corrections captured by the D-brane Dirac-Born-Infeld action. Our analysis then allows an embedding of the D-brane moduli effective action into an N=1 supergravity formulation. The effects of the potential-dependent kinetic terms may be very important if one of the scalars is the inflaton, since they lead to a flattening of the scalar potential. We analyze this flattening effect in detail and compute its impact on the CMB observables for single-field inflation with monomial potentials.

Higher derivatives in gauge transformations

International Nuclear Information System (INIS)

Gogilidze, S.A.; Sanadze, V.V.; Tkebuchava, F.G.

1992-01-01

The mechanism of appearance of highher derivatives of coordinates in the symmetry transformation law of the second Noether's theorem is established. It is shown that the corresponding transformations are canonical in the extended phase space. 15 refs

On the OSp(1,4) renormalisable theory of supergravity with higher derivatives

International Nuclear Information System (INIS)

Namazie, M.A.

1980-01-01

Supergravity Langrangian invariant under local orthosymplectic and general coordinate transformations is presented. It is conjectured that the Lagrangian describes a renormalisable theory. New features in this formulation are the introduction of a group invariant metric tensor and the corresponding connection. As in other higher-derivative theories metric ghosts are present. (author)

Modeling the Interest Rate Term Structure: Derivatives Contracts Dynamics and Evaluation

Directory of Open Access Journals (Sweden)

Pedro L. Valls Pereira

2005-06-01

Full Text Available This article deals with a model for the term structure of interest rates and the valuation of derivative contracts directly dependent on it. The work is of a theoretical nature and deals, exclusively, with continuous time models, making ample use of stochastic calculus results and presents original contributions that we consider relevant to the development of the fixed income market modeling. We develop a new multifactorial model of the term structure of interest rates. The model is based on the decomposition of the yield curve into the factors level, slope, curvature, and the treatment of their collective dynamics. We show that this model may be applied to serve various objectives: analysis of bond price dynamics, valuation of derivative contracts and also market risk management and formulation of operational strategies which is presented in another article.

A generalized one-factor term structure model and pricing of interest rate derivative securities

NARCIS (Netherlands)

Jiang, George J.

1997-01-01

The purpose of this paper is to propose a nonparametric interest rate term structure model and investigate its implications on term structure dynamics and prices of interest rate derivative securities. The nonparametric spot interest rate process is estimated from the observed short-term interest

Higher derivative discontinuous solutions to linear ordinary differential equations: a new route to complexity?

International Nuclear Information System (INIS)

Datta, Dhurjati Prasad; Bose, Manoj Kumar

2004-01-01

We present a new one parameter family of second derivative discontinuous solutions to the simplest scale invariant linear ordinary differential equation. We also point out how the construction could be extended to generate families of higher derivative discontinuous solutions as well. The discontinuity can occur only for a subset of even order derivatives, viz., 2nd, 4th, 8th, 16th,.... The solutions are shown to break the discrete parity (reflection) symmetry of the underlying equation. These results are expected to gain significance in the contemporary search of a new dynamical principle for understanding complex phenomena in nature

Low rank approach to computing first and higher order derivatives using automatic differentiation

International Nuclear Information System (INIS)

Reed, J. A.; Abdel-Khalik, H. S.; Utke, J.

2012-01-01

This manuscript outlines a new approach for increasing the efficiency of applying automatic differentiation (AD) to large scale computational models. By using the principles of the Efficient Subspace Method (ESM), low rank approximations of the derivatives for first and higher orders can be calculated using minimized computational resources. The output obtained from nuclear reactor calculations typically has a much smaller numerical rank compared to the number of inputs and outputs. This rank deficiency can be exploited to reduce the number of derivatives that need to be calculated using AD. The effective rank can be determined according to ESM by computing derivatives with AD at random inputs. Reduced or pseudo variables are then defined and new derivatives are calculated with respect to the pseudo variables. Two different AD packages are used: OpenAD and Rapsodia. OpenAD is used to determine the effective rank and the subspace that contains the derivatives. Rapsodia is then used to calculate derivatives with respect to the pseudo variables for the desired order. The overall approach is applied to two simple problems and to MATWS, a safety code for sodium cooled reactors. (authors)

Studies in higher-derivative gravitation

International Nuclear Information System (INIS)

Dutt, S.K.

1987-01-01

In this work two formulations of gravitation in which the action includes the second-derivatives of the metric in a non-trivial fashion are investigated. In the first part, the gauge theory of gravitation proposed by Yang in 1974 is investigated. The implications of coupling the pure space equations to matter sources via the action principle proposed by Yang is studied. It is shown that this action principle does not couple to matter sources in a satisfactory fashion. An earlier study by Fairchild along similar lines is critically examined. It is argued that Fairchild's action functional, and his objections to Yang's gauge approach to gravitation, arise from a not very meaningful analogy with the case of a general gauge field. Also, a conjecture originated in that work is refuted. A modification of Yang's action functional is provided which leads to both the Einstein and Yang field-equations. This system is shown to have non-trivial solutions in the presence of matter. An additional advantage is that the unphysical solutions of the pure space equations can be ruled out. It is shown that the joint system of Einstein and Yang field-equations leads to a physically viable cosmological model based on the Robertson-Walker metric, which satisfies both sets of field-equations. In the second part of this work, the Hamiltonian for pure gravity in Einstein's theory is obtained directly from the Hilbert Lagrangian. Since the Lagrangian depends upon the second-derivatives of the metric tensor, first the Hamiltonian formulation for a Lagrangian which may, in general depend upon the Nth-order time derivatives of the dynamical variables is developed

Optimization of mixed quantum-classical dynamics: Time-derivative coupling terms and selected couplings

International Nuclear Information System (INIS)

Pittner, Jiri; Lischka, Hans; Barbatti, Mario

2009-01-01

The usage of time-derivative non-adiabatic coupling terms and partially coupled time-dependent equations are investigated to accelerate non-adiabatic dynamics simulations at multireference configuration interaction (MRCI) level. The quality of the results and computational costs are compared against non-adiabatic benchmark dynamics calculations using non-adiabatic coupling vectors. In the comparison between the time-derivative couplings and coupling vectors, deviations in the adiabatic population of individual trajectories were observed in regions of rapid variation of the coupling terms. They, however, affected the average adiabatic population to only about 5%. For small multiconfiguration spaces, dynamics with time-derivative couplings are significantly faster than those with coupling vectors. This relation inverts for larger configuration spaces. The use of the partially coupled equations approach speeds up the simulations significantly while keeping the deviations in the population below few percent. Imidazole and the methaniminium cation are used as test examples

Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel.

Science.gov (United States)

Oyama, Hiroshi; Takahashi, Koji; Tanaka, Yoshikazu; Takemoto, Hiroshi; Haga, Hisashi

2018-01-01

It takes several months to form the 3-dimensional morphology of the human embryonic brain. Therefore, establishing a long-term culture method for neuronal tissues derived from human induced pluripotent stem (iPS) cells is very important for studying human brain development. However, it is difficult to keep primary neurons alive for more than 3 weeks in culture. Moreover, long-term adherent culture to maintain the morphology of telencephalic neuron aggregates induced from human iPS cells is also difficult. Although collagen gel has been widely used to support long-term culture of cells, it is not clear whether human iPS cell-derived neuron aggregates can be cultured for long periods on this substrate. In the present study, we differentiated human iPS cells to telencephalic neuron aggregates and examined long-term culture of these aggregates on collagen gel. The results indicated that these aggregates could be cultured for over 3 months by adhering tightly onto collagen gel. Furthermore, telencephalic neuronal precursors within these aggregates matured over time and formed layered structures. Thus, long-term culture of telencephalic neuron aggregates derived from human iPS cells on collagen gel would be useful for studying human cerebral cortex development.Key words: Induced pluripotent stem cell, forebrain neuron, collagen gel, long-term culture.

Statistical properties of derivatives: A journey in term structures

Science.gov (United States)

Lautier, Delphine; Raynaud, Franck

2011-06-01

This article presents an empirical study of 13 derivative markets for commodities and financial assets. The study goes beyond statistical analysis by including the maturity as a variable for the daily returns of futures contracts from 1998 to 2010, and for delivery dates up to 120 months. We observe that the mean and variance of the commodities follow a scaling behavior in the maturity dimension with an exponent characteristic of the Samuelson effect. The comparison between the tails of the probability distribution according to the expiration dates shows that there is a segmentation in the fat tails exponent term structure above the Lévy stable region. Finally, we compute the average tail exponent for each maturity, and we observe two regimes of extreme events for derivative markets, reminiscent of a phase diagram with a sharp transition at the 18th delivery month.

Removal of boron(III) by N-methylglucamine-type cellulose derivatives with higher adsorption rate

International Nuclear Information System (INIS)

Inukai, Yoshinari; Tanaka, Yoshiharu; Matsuda, Toshio; Mihara, Nobutake; Yamada, Kouji; Nambu, Nobuyoshi; Itoh, Osamu; Doi, Takao; Kaida, Yasuhiko; Yasuda, Seiji

2004-01-01

To obtain adsorbents for boron(III) derived from a natural polymer, two forms (powder and fiber) of N-methylglucamine-type cellulose derivatives were newly synthesized. After the graft polymerization of two forms of cellulose with vinyl monomer having epoxy groups, the N-methylglucamine-type cellulose derivatives were obtained by the reaction of the grafted cellulose with N-methylglucamine. The adsorption capacities of the cellulose derivatives for boron(III) were the same levels as that of a commercially available N-methylglucamine-type polystyrene resin. However, the cellulose derivatives adsorbed boron(III) more quickly than the polystyrene resin. The adsorption and desorption of boron(III) with a column method using the cellulose fiber were achieved at a higher flow rate than that using the polystyrene resin. In addition, the boron(III), adsorbed on the cellulose fiber column, was quantitatively recovered with dilute hydrochloric acid in 20- and 200-fold increased concentrations. Consequently, it was found that the cellulose derivatives were superior to the polystyrene resin as adsorbents for boron(III) for treatment of a large quantity of wastewater

Isolation and cellular properties of mesenchymal cells derived from the decidua of human term placenta.

Science.gov (United States)

Kanematsu, Daisuke; Shofuda, Tomoko; Yamamoto, Atsuyo; Ban, Chiaki; Ueda, Takafumi; Yamasaki, Mami; Kanemura, Yonehiro

2011-09-01

The clinical promise of cell-based therapies is generally recognized, and has driven an intense search for good cell sources. In this study, we isolated plastic-adherent cells from human term decidua vera, called decidua-derived-mesenchymal cells (DMCs), and compared their properties with those of bone marrow-derived-mesenchymal stem cells (BM-MSCs). The DMCs strongly expressed the mesenchymal cell marker vimentin, but not cytokeratin 19 or HLA-G, and had a high proliferative potential. That is, they exhibited a typical fibroblast-like morphology for over 30 population doublings. Cells phenotypically identical to the DMCs were identified in the decidua vera, and genotyping confirmed that the DMCs were derived from the maternal components of the fetal adnexa. Flow cytometry analysis showed that the expression pattern of CD antigens on the DMCs was almost identical to that on BM-MSCs, but some DMCs expressed the CD45 antigen, and over 50% of them also expressed anti-fibroblast antigen. In vitro, the DMCs showed good differentiation into chondrocytes and moderate differentiation into adipocytes, but scant evidence of osteogenesis, compared with the BM-MSCs. Gene expression analysis showed that, compared with BM-MSCs, the DMCs expressed higher levels of TWIST2 and RUNX2 (which are associated with early mesenchymal development and/or proliferative capacity), several matrix metalloproteinases (MMP1, 3, 10, and 12), and cytokines (BMP2 and TGFB2), and lower levels of MSX2, interleukin 26, and HGF. Although DMCs did not show the full multipotency of BM-MSCs, their higher proliferative ability indicates that their cultivation would require less maintenance. Furthermore, the use of DMCs avoids the ethical concerns associated with the use of embryonic tissues, because they are derived from the maternal portion of the placenta, which is otherwise discarded. Thus, the unique properties of DMCs give them several advantages for clinical use, making them an interesting and

Complex-mass shell renormalization of the higher-derivative electrodynamics

Energy Technology Data Exchange (ETDEWEB)

Turcati, Rodrigo [SISSA, Trieste (Italy); INFN, Sezione di Trieste, Trieste (Italy); Universidade Federal do Espirito Santo, Departamento de Fisica e Quimica, Vitoria, ES (Brazil); Laboratorio de Fisica Experimental (LAFEX), Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro (Brazil); Neves, Mario Junior [Universidade Federal Rural do Rio de Janeiro, Departamento de Fisica, Rio de Janeiro (Brazil)

2016-08-15

We consider a higher-derivative extension of QED modified by the addition of a gauge-invariant dimension-6 kinetic operator in the U(1) gauge sector. The Feynman diagrams at one-loop level are then computed. The modification in the spin-1 sector leads the electron self-energy and vertex corrections diagrams finite in the ultraviolet regime. Indeed, no regularization prescription is used to calculate these diagrams because the modified propagator always occurs coupled to conserved currents. Moreover, besides the usual massless pole in the spin-1 sector, there is the emergence of a massive one, which becomes complex when computing the radiative corrections at one-loop order. This imaginary part defines the finite decay width of the massive mode. To check consistency, we also derive the decay length using the electron-positron elastic scattering and show that both results are equivalent. Because the presence of this unstable mode, the standard renormalization procedures cannot be used and is necessary adopt an appropriate framework to perform the perturbative renormalization. For this purpose, we apply the complex-mass shell scheme (CMS) to renormalize the aforementioned model. As an application of the formalism developed, we estimate a quantum bound on the massive parameter using the measurement of the electron anomalous magnetic moment and compute the Uehling potential. At the end, the renormalization group is analyzed. (orig.)

Absence of higher derivatives in the renormalization of propagators in quantum field theories with infinitely many couplings

International Nuclear Information System (INIS)

Anselmi, Damiano

2003-01-01

I study some aspects of the renormalization of quantum field theories with infinitely many couplings in arbitrary spacetime dimensions. I prove that when the spacetime manifold admits a metric of constant curvature, the propagator is not affected by terms with higher derivatives. More generally, certain Lagrangian terms are not turned on by renormalization, if they are absent at the tree level. This restricts the form of the action of a non-renormalizable theory, and has applications to quantum gravity. The new action contains infinitely many couplings, but not all of the ones that might have been expected. In quantum gravity, the metric of constant curvature is an extremal, but not a minimum, of the complete action. Nonetheless, it appears to be the right perturbative vacuum, at least when the curvature is negative, suggesting that the quantum vacuum has a negative asymptotically constant curvature. The results of this paper give also a set of rules for a more economical use of effective quantum field theories and suggest that it might be possible to give mathematical sense to theories with infinitely many couplings at high energies, to search for physical predictions

Impact of higher twist terms on the analysis of scaling violation

International Nuclear Information System (INIS)

Barnett, R.M.

1979-09-01

A critical discussion is given of analyses of scaling violation in deep-inelastic scattering in the context of QCD. Several possible approaches are examined. Higher twist contributions are defined, and it is shown that they can have a crucial impact on tests of QCD. Higher twist terms can dramatically affect R = sigma/sub L//sigma/sub T/. QCD may be harder to test than previously realized. 17 references

Higher-order Skyrme hair of black holes

Science.gov (United States)

Gudnason, Sven Bjarke; Nitta, Muneto

2018-05-01

Higher-order derivative terms are considered as replacement for the Skyrme term in an Einstein-Skyrme-like model in order to pinpoint which properties are necessary for a black hole to possess stable static scalar hair. We find two new models able to support stable black hole hair in the limit of the Skyrme term being turned off. They contain 8 and 12 derivatives, respectively, and are roughly the Skyrme-term squared and the so-called BPS-Skyrme-term squared. In the twelfth-order model we find that the lower branches, which are normally unstable, become stable in the limit where the Skyrme term is turned off. We check this claim with a linear stability analysis. Finally, we find for a certain range of the gravitational coupling and horizon radius, that the twelfth-order model contains 4 solutions as opposed to 2. More surprisingly, the lowest part of the would-be unstable branch turns out to be the stable one of the 4 solutions.

Is higher-derivative gravity a good therapy to the causal pathologies of Goedel-type universes

International Nuclear Information System (INIS)

Accioly, A.J.

1988-01-01

The possibility of considering higher-derivative gravity as a therapy to the causal pathologies of Goedel-type universes is investigated. As a consequence an unusual cosmological solution is obtained. (author) [pt

Nonlinear massive spin-2 field generated by higher derivative gravity

International Nuclear Information System (INIS)

Magnano, Guido; Sokolowski, Leszek M.

2003-01-01

We present a systematic exposition of the Lagrangian field theory for the massive spin-2 field generated in higher-derivative gravity upon reduction to a second-order theory by means of the appropriate Legendre transformation. It has been noticed by various authors that this nonlinear field overcomes the well-known inconsistency of the theory for a linear massive spin-2 field interacting with Einstein's gravity. Starting from a Lagrangian quadratically depending on the Ricci tensor of the metric, we explore the two possible second-order pictures usually called '(Helmholtz-)Jordan frame' and 'Einstein frame'. In spite of their mathematical equivalence, the two frames have different structural properties: in Einstein frame, the spin-2 field is minimally coupled to gravity, while in the other frame it is necessarily coupled to the curvature, without a separate kinetic term. We prove that the theory admits a unique and linearly stable ground state solution, and that the equations of motion are consistent, showing that these results can be obtained independently in either frame (each frame therefore provides a self-contained theory). The full equations of motion and the (variational) energy-momentum tensor for the spin-2 field in Einstein frame are given, and a simple but non-trivial exact solution to these equations is found. The comparison of the energy-momentum tensors for the spin-2 field in the two frames suggests that the Einstein frame is physically more acceptable. We point out that the energy-momentum tensor generated by the Lagrangian of the linearized theory is unrelated to the corresponding tensor of the full theory. It is then argued that the ghost-like nature of the nonlinear spin-2 field, found long ago in the linear approximation, may not be so harmful to classical stability issues, as has been expected

Higher order derivatives via Hamilton-Jacobi approach

International Nuclear Information System (INIS)

Bertin, M.C.; Pimentel, B.M.; Pompeia, P.J.

2006-01-01

In this work we will show how can be derived a general method for dealing with Lagrangians containing high order derivatives using the Hamilton-Jacobi Formalism for singular systems. By the expansion the configuration space of a n dimensional system we will be able to introduce first order actions and build the equations of motion of the system. We will work with the Generalized Electrodynamics of Podolsky as an example. (author)

Stable bounce and inflation in non-local higher derivative cosmology

International Nuclear Information System (INIS)

Biswas, Tirthabir; Koshelev, Alexey S.; Mazumdar, Anupam; Vernov, Sergey Yu.

2012-01-01

One of the greatest problems of primordial inflation is that the inflationary space-time is past-incomplete. This is mainly because Einstein's GR suffers from a space-like Big Bang singularity. It has recently been shown that ghost-free, non-local higher-derivative ultra-violet modifications of Einstein's gravity may be able to resolve the cosmological Big Bang singularity via a non-singular bounce. Within the framework of such non-local cosmological models, we are going to study both sub- and super-Hubble perturbations around an inflationary trajectory which is preceded by the Big Bounce in the past, and demonstrate that the inflationary trajectory has an ultra-violet completion and that perturbations do not suffer from any pathologies

Signs and stability in higher-derivative gravity

Science.gov (United States)

Narain, Gaurav

2018-02-01

Perturbatively renormalizable higher-derivative gravity in four space-time dimensions with arbitrary signs of couplings has been considered. Systematic analysis of the action with arbitrary signs of couplings in Lorentzian flat space-time for no-tachyons, fixes the signs. Feynman + i𝜖 prescription for these signs further grants necessary convergence in path-integral, suppressing the field modes with large action. This also leads to a sensible wick rotation where quantum computation can be performed. Running couplings for these sign of parameters make the massive tensor ghost innocuous leading to a stable and ghost-free renormalizable theory in four space-time dimensions. The theory has a transition point arising from renormalization group (RG) equations, where the coefficient of R2 diverges without affecting the perturbative quantum field theory (QFT). Redefining this coefficient gives a better handle over the theory around the transition point. The flow equations push the flow of parameters across the transition point. The flow beyond the transition point is analyzed using the one-loop RG equations which shows that the regime beyond the transition point has unphysical properties: there are tachyons, the path-integral loses positive definiteness, Newton’s constant G becomes negative and large, and perturbative parameters become large. These shortcomings indicate a lack of completeness beyond the transition point and need of a nonperturbative treatment of the theory beyond the transition point.

Flow equation of quantum Einstein gravity in a higher-derivative truncation

International Nuclear Information System (INIS)

Lauscher, O.; Reuter, M.

2002-01-01

Motivated by recent evidence indicating that quantum Einstein gravity (QEG) might be nonperturbatively renormalizable, the exact renormalization group equation of QEG is evaluated in a truncation of theory space which generalizes the Einstein-Hilbert truncation by the inclusion of a higher-derivative term (R 2 ). The beta functions describing the renormalization group flow of the cosmological constant, Newton's constant, and the R 2 coupling are computed explicitly. The fixed point properties of the 3-dimensional flow are investigated, and they are confronted with those of the 2-dimensional Einstein-Hilbert flow. The non-Gaussian fixed point predicted by the latter is found to generalize to a fixed point on the enlarged theory space. In order to test the reliability of the R 2 truncation near this fixed point we analyze the residual scheme dependence of various universal quantities; it turns out to be very weak. The two truncations are compared in detail, and their numerical predictions are found to agree with a surprisingly high precision. Because of the consistency of the results it appears increasingly unlikely that the non-Gaussian fixed point is an artifact of the truncation. If it is present in the exact theory QEG is probably nonperturbatively renormalizable and ''asymptotically safe.'' We discuss how the conformal factor problem of Euclidean gravity manifests itself in the exact renormalization group approach and show that, in the R 2 truncation, the investigation of the fixed point is not afflicted with this problem. Also the Gaussian fixed point of the Einstein-Hilbert truncation is analyzed; it turns out that it does not generalize to a corresponding fixed point on the enlarged theory space

A comparison of different methods to implement higher order derivatives of density functionals

Energy Technology Data Exchange (ETDEWEB)

van Dam, Hubertus J.J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2016-05-18

Density functional theory is the dominant approach in electronic structure methods today. To calculate properties higher order derivatives of the density functionals are required. These derivatives might be implemented manually,by automatic differentiation, or by symbolic algebra programs. Different authors have cited different reasons for using the particular method of their choice. This paper presents work where all three approaches were used and the strengths and weaknesses of each approach are considered. It is found that all three methods produce code that is suffficiently performanted for practical applications, despite the fact that our symbolic algebra generated code and our automatic differentiation code still have scope for significant optimization. The automatic differentiation approach is the best option for producing readable and maintainable code.

Comparison of Preterm and Term Wharton's Jelly-Derived Mesenchymal Stem Cell Properties in Different Oxygen Tensions.

Science.gov (United States)

Balgi-Agarwal, Saloni; Winter, Caitlyn; Corral, Alexis; Mustafa, Shamimunisa B; Hornsby, Peter; Moreira, Alvaro

2018-06-27

Mesenchymal stem cells (MSCs) have shown promise as therapeutic agents in treating morbidities associated with premature birth. MSCs derived from the human umbilical cord are easy to isolate and have low immunogenicity and a robust ability to secrete paracrine factors. To date, there are no studies evaluating preterm versus term umbilical cord tissue-derived MSCs. Therefore, our aim was twofold: (1) to compare stem cell properties in preterm versus term MSCs and (2) to examine the impact of oxygen tension on stem cell behavior. Umbilical cord tissue was obtained from 5 preterm and 5 term neonates. The cells were isolated and characterized as MSCs in accordance with the International Society for Cellular Therapy. We exposed MSCs to different oxygen tensions to examine the impact of environmental factors on cell performance. We studied the following stem cell properties: (i) motility, (ii) proliferation, (iii) senescence, (iv) cell viability, (v) colony-forming unit efficiency, and (vi) inflammatory cytokine expression. Under normoxia (21% O2), cells from preterm and term infants had similar properties. Under hypoxic conditions (1% O2), term MSCs had better cell proliferation; however, cells exposed to hyperoxia (90% O2) had the slowest motility and lowest cell viability (p cytokine expression between the groups. The term cells demonstrated more colony-forming efficiency than the preterm cells. In sum, our preliminary findings suggest that MSCs derived from term and preterm umbilical cords have similar characteristics, offering the potential of future autologous/allogeneic MSC transplants in neonates. © 2018 S. Karger AG, Basel.

Higher derivative operators from Scherk-Schwarz supersymmetry breaking on Τ2/Z2

International Nuclear Information System (INIS)

Ghilencea, D.M.

2005-09-01

In orbifold compactifications on Τ 2 /Z 2 with Scherk-Schwarz supersymmetry breaking, it is shown that (brane-localised) superpotential interactions and (bulk) gauge interactions generate at one-loop higher derivative counterterms to the mass of the brane (or zero-mode of the bulk) scalar field. These brane-localised operators are generated by integrating out the bulk modes of the initial theory which, although supersymmetric, is nevertheless non-renormalisable. It is argued that such operators, of non-perturbative origin and not protected by non-renormalisation theorems, are generic in orbifold compactifications and play a crucial role in the UV behaviour of the two-point Green function of the scalar field self-energy. Their presence in the action with unknown coefficients prevents one from making predictions about physics at (momentum) scales close to/above the compactification scale(s). Our results extend to the case of two dimensional orbifolds, previous findings for S 1 /Z 2 and S 1 /(Z 2 x Z 2 ') compactifications where brane-localised higher derivative operators are also dynamically generated at loop level, regardless of the details of the supersymmetry breaking mechanism. We stress the importance of these operators for the hierarchy and the cosmological constant problems in compactified theories. (orig.)

Fractional Hamiltonian analysis of higher order derivatives systems

International Nuclear Information System (INIS)

Baleanu, Dumitru; Muslih, Sami I.; Tas, Kenan

2006-01-01

The fractional Hamiltonian analysis of 1+1 dimensional field theory is investigated and the fractional Ostrogradski's formulation is obtained. The fractional path integral of both simple harmonic oscillator with an acceleration-squares part and a damped oscillator are analyzed. The classical results are obtained when fractional derivatives are replaced with the integer order derivatives

Fractional variational calculus in terms of Riesz fractional derivatives

International Nuclear Information System (INIS)

Agrawal, O P

2007-01-01

This paper presents extensions of traditional calculus of variations for systems containing Riesz fractional derivatives (RFDs). Specifically, we present generalized Euler-Lagrange equations and the transversality conditions for fractional variational problems (FVPs) defined in terms of RFDs. We consider two problems, a simple FVP and an FVP of Lagrange. Results of the first problem are extended to problems containing multiple fractional derivatives, functions and parameters, and to unspecified boundary conditions. For the second problem, we present Lagrange-type multiplier rules. For both problems, we develop the Euler-Lagrange-type necessary conditions which must be satisfied for the given functional to be extremum. Problems are considered to demonstrate applications of the formulations. Explicitly, we introduce fractional momenta, fractional Hamiltonian, fractional Hamilton equations of motion, fractional field theory and fractional optimal control. The formulations presented and the resulting equations are similar to the formulations for FVPs given in Agrawal (2002 J. Math. Anal. Appl. 272 368, 2006 J. Phys. A: Math. Gen. 39 10375) and to those that appear in the field of classical calculus of variations. These formulations are simple and can be extended to other problems in the field of fractional calculus of variations

Boundary terms and junction conditions for the DGP π-Lagrangian and galileon

International Nuclear Information System (INIS)

Dyer, Ethan; Hinterbichler, Kurt

2009-01-01

In the decoupling limit of DGP, π describes the brane-bending degree of freedom. It obeys second order equations of motion, yet it is governed by a higher derivative Lagrangian. We show that, analogously to the Einstein-Hilbert action for GR, the π-Lagrangian requires Gibbons-Hawking-York type boundary terms to render the variational principle well-posed. These terms are important if there are other boundaries present besides the DGP brane, such as in higher dimensional cascading DGP models. We derive the necessary boundary terms in two ways. First, we derive them directly from the brane-localized π-Lagrangian by demanding well-posedness of the action. Second, we calculate them directly from the bulk, taking into account the Gibbons-Hawking-York terms in the bulk Einstein-Hilbert action. As an application, we use the new boundary terms to derive Israel junction conditions for π across a sheet-like source. In addition, we calculate boundary terms and junction conditions for the galileons which generalize the DGP π-Lagrangian, showing that the boundary term for the n-th order galileon is the (n-1)-th order galileon.

Higher integrity of the motor and visual pathways in long-term video game players.

Science.gov (United States)

Zhang, Yang; Du, Guijin; Yang, Yongxin; Qin, Wen; Li, Xiaodong; Zhang, Quan

2015-01-01

Long term video game players (VGPs) exhibit superior visual and motor skills compared with non-video game control subjects (NVGCs). However, the neural basis underlying the enhanced behavioral performance remains largely unknown. To clarify this issue, the present study compared the whiter matter integrity within the corticospinal tracts (CST), the superior longitudinal fasciculus (SLF), the inferior longitudinal fasciculus (ILF), and the inferior fronto-occipital fasciculus (IFOF) between the VGPs and the NVGCs using diffusion tensor imaging. Compared with the NVGCs, voxel-wise comparisons revealed significantly higher fractional anisotropy (FA) values in some regions within the left CST, left SLF, bilateral ILF, and IFOF in VGPs. Furthermore, higher FA values in the left CST at the level of cerebral peduncle predicted a faster response in visual attention tasks. These results suggest that higher white matter integrity in the motor and higher-tier visual pathways is associated with long-term video game playing, which may contribute to the understanding on how video game play influences motor and visual performance.

Current interactions from the one-form sector of nonlinear higher-spin equations

Science.gov (United States)

Gelfond, O. A.; Vasiliev, M. A.

2018-06-01

The form of higher-spin current interactions in the sector of one-forms is derived from the nonlinear higher-spin equations in AdS4. Quadratic corrections to higher-spin equations are shown to be independent of the phase of the parameter η = exp ⁡ iφ in the full nonlinear higher-spin equations. The current deformation resulting from the nonlinear higher-spin equations is represented in the canonical form with the minimal number of space-time derivatives. The non-zero spin-dependent coupling constants of the resulting currents are determined in terms of the higher-spin coupling constant η η bar . Our results confirm the conjecture that (anti-)self-dual nonlinear higher-spin equations result from the full system at (η = 0) η bar = 0.

Determination of angle of light deflection in higher-derivative gravity theories

Science.gov (United States)

Xu, Chenmei; Yang, Yisong

2018-03-01

Gravitational light deflection is known as one of three classical tests of general relativity and the angle of deflection may be computed explicitly using approximate or exact solutions describing the gravitational force generated from a point mass. In various generalized gravity theories, however, such explicit determination is often impossible due to the difficulty in obtaining an exact expression for the deflection angle. In this work, we present some highly effective globally convergent iterative methods to determine the angle of semiclassical gravitational deflection in higher- and infinite-derivative formalisms of quantum gravity theories. We also establish the universal properties that the deflection angle always stays below the classical Einstein angle and is a strictly decreasing function of the incident photon energy, in these formalisms.

Inflationary universe from higher derivative quantum gravity coupled with scalar electrodynamics

Energy Technology Data Exchange (ETDEWEB)

Myrzakulov, R. [Department of General & Theoretical Physics and Eurasian Center for Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Odintsov, S.D. [Consejo Superior de Investigaciones Científicas, ICE/CSIC-IEEC, Campus UAB, Facultat de Ciències, Torre C5-Parell-2a pl, E-08193 Bellaterra, Barcelona (Spain); Institut de Ciencies de l' Espai (IEEC-CSIC), Campus UAB, Carrer de Can Magrans, s/n 08193 Cerdanyola del Valles, Barcelona (Spain); Tomsk State Pedagogical University, 634050 Tomsk (Russian Federation); Tomsk State University of Control Systems and Radioelectronics (TUSUR) 634050 Tomsk (Russian Federation); Sebastiani, L., E-mail: lorenzo.sebastiani@unitn.it [Department of General & Theoretical Physics and Eurasian Center for Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan)

2016-06-15

We study inflation for a quantum scalar electrodynamics model in curved space–time and for higher-derivative quantum gravity (QG) coupled with scalar electrodynamics. The corresponding renormalization-group (RG) improved potential is evaluated for both theories in Jordan frame where non-minimal scalar-gravitational coupling sector is explicitly kept. The role of one-loop quantum corrections is investigated by showing how these corrections enter in the expressions for the slow-roll parameters, the spectral index and the tensor-to-scalar ratio and how they influence the bound of the Hubble parameter at the beginning of the primordial acceleration. We demonstrate that the viable inflation maybe successfully realized, so that it turns out to be consistent with last Planck and BICEP2/Keck Array data.

RG flow and thermodynamics of causal horizons in higher-derivative AdS gravity

International Nuclear Information System (INIS)

Banerjee, Shamik; Bhattacharyya, Arpan

2016-01-01

In http://arxiv.org/abs/1508.01343 [hep-th], one of the authors proposed that in AdS/CFT the gravity dual of the boundary c-theorem is the second law of thermodynamics satisfied by causal horizons in AdS and this was verified for Einstein gravity in the bulk. In this paper we verify this for higher derivative theories. We pick up theories for which an entropy expression satisfying the second law exists and show that the entropy density evaluated on the causal horizon in a RG flow geometry is a holographic c-function. We also prove that given a theory of gravity described by a local covariant action in the bulk a sufficient condition to ensure holographic c-theorem is that the second law of causal horizon thermodynamics be satisfied by the theory. This allows us to explicitly construct holographic c-function in a theory where there is curvature coupling between gravity and matter and standard null energy condition cannot be defined although second law is known to hold. Based on the duality between c-theorem and the second law of causal horizon thermodynamics proposed in http://arxiv.org/abs/1508.01343 [hep-th] and the supporting calculations of this paper we conjecture that every Unitary higher derivative theory of gravity in AdS satisfies the second law of causal horizon thermodynamics. If this is not true then c-theorem will be violated in a unitary Lorentz invariant field theory.

Boundary terms in Nambu-Goto string action

OpenAIRE

Hadasz, Leszek; Wegrzyn, Pawel

1994-01-01

We investigate classical strings defined by the Nambu-Goto action with the boundary term added. We demonstrate that the latter term has a significant bearing on the string dynamics. It is confirmed that new action terms that depend on higher order derivatives of string coordinates cannot be considered as continuous perturbations from the starting string functional. In the case the boundary term reduces to the Gauss-Bonnet term, a stability analysis is performed on the rotating rigid string so...

Higher-order blackhole solutions in N=2 supergravity and Calabi-Yau string backgrounds

NARCIS (Netherlands)

Behrndt, K.; Cardoso, G.L.; de Wit, B.Q.P.J.; Lüst, D.; Mohaupt, T.; Sabra, W.A.

1998-01-01

Based on special geometry, we consider corrections to N=2 extremal black-hole solutions and their entropies originating from higher-order derivative terms in N=2 supergravity. These corrections are described by a holomorphic function, and the higher-order black-hole solutions can be expressed in

Electron-positron annihilation into hadrons at the higher-loop levels

Energy Technology Data Exchange (ETDEWEB)

Nesterenko, A.V. [Joint Institute for Nuclear Research, Bogoliubov Laboratory of Theoretical Physics, Dubna (Russian Federation)

2017-12-15

The strong corrections to the R-ratio of electron-positron annihilation into hadrons are studied at the higher-loop levels. Specifically, the derivation of a general form of the commonly employed approximate expression for the R-ratio (which constitutes its truncated re-expansion at high energies) is delineated, the appearance of the pertinent π{sup 2}-terms is expounded, and their basic features are examined. It is demonstrated that the validity range of such approximation is strictly limited to √(s)/Λ > exp(π/2) ≅ 4.81 and that it converges rather slowly when the energy scale approaches this value. The spectral function required for the proper calculation of the R-ratio is explicitly derived and its properties at the higher-loop levels are studied. The developed method of calculation of the spectral function enables one to obtain the explicit expression for the latter at an arbitrary loop level. By making use of the derived spectral function the proper expression for the R-ratio is calculated up to the five-loop level and its properties are examined. It is shown that the loop convergence of the proper expression for the R-ratio is better than that of its commonly employed approximation. The impact of the omitted higher-order π{sup 2}-terms on the latter is also discussed. (orig.)

A new derivation of Luescher F-term and fluctuations around the giant magnon

International Nuclear Information System (INIS)

Heller, Michal P.; Janik, Romuald A.; Lukowski, Tomasz

2008-01-01

In this paper we give a new derivation of the generalized Luescher F-term formula from a summation over quadratic fluctuations around a given soliton. The result is very general providing that S-matrix is diagonal and is valid for arbitrary dispersion relation. We then apply this formalism to compute the leading finite size corrections to the giant magnon dispersion relation coming from quantum fluctuations.

Contribution of higher order terms in the reductive perturbation theory, 2

International Nuclear Information System (INIS)

Ichikawa, Y.H.; Mitsuhashi, Teruo; Konno, Kimiaki.

1977-01-01

Contribution of higher order terms in the reductive perturbation theory has been investigated for nonlinear propagation of strongly dispersive ion plasma wave. The basic set of fluid equation is reduced to a coupled set of the nonlinear Schroedinger equation for the first order perturbed potential and a linear inhomogeneous equation for the second order perturbed potential. A steady state solution of the coupled set of equations has been solved analytically in the asymptotic limit of small wave number. (auth.)

Higher derivative extensions of 3d Chern-Simons models: conservation laws and stability

International Nuclear Information System (INIS)

Kaparulin, D.S.; Karataeva, I.Yu.; Lyakhovich, S.L.

2015-01-01

We consider the class of higher derivative 3d vector field models with the field equation operator being a polynomial of the Chern-Simons operator. For the nth-order theory of this type, we provide a general recipe for constructing n-parameter family of conserved second rank tensors. The family includes the canonical energy-momentum tensor, which is unbounded, while there are bounded conserved tensors that provide classical stability of the system for certain combinations of the parameters in the Lagrangian. We also demonstrate the examples of consistent interactions which are compatible with the requirement of stability. (orig.)

Statistical mechanics of neocortical interactions. Derivation of short-term-memory capacity

Science.gov (United States)

Ingber, Lester

1984-06-01

A theory developed by the author to describe macroscopic neocortical interactions demonstrates that empirical values of chemical and electrical parameters of synaptic interactions establish several minima of the path-integral Lagrangian as a function of excitatory and inhibitory columnar firings. The number of possible minima, their time scales of hysteresis and probable reverberations, and their nearest-neighbor columnar interactions are all consistent with well-established empirical rules of human short-term memory. Thus, aspects of conscious experience are derived from neuronal firing patterns, using modern methods of nonlinear nonequilibrium statistical mechanics to develop realistic explicit synaptic interactions.

Thermal electron heating rate: a derivation

International Nuclear Information System (INIS)

Hoegy, W.R.

1983-11-01

The thermal electron heating rate is an important heat source term in the ionospheric electron energy balance equation, representing heating by photoelectrons or by precipitating higher energy electrons. A formula for the thermal electron heating rate is derived from the kinetic equation using the electron-electron collision operator as given by the unified theory of Kihara and Aono. This collision operator includes collective interactions to produce a finite collision operator with an exact Coulomb logarithm term. The derived heating rate O(e) is the sum of three terms, O(e) O(p) + S + O(int), which are respectively: (1) primary electron production term giving the heating from newly created electrons that have not yet suffered collisions with the ambient electrons, (2) a heating term evaluated on the energy surface m(e)/2 E(T) at the transition between Maxwellian and tail electrons at E(T), and (3) the integral term representing heating of Maxwellian electrons by energetic tail electrons at energies ET. Published ionospheric electron temperature studies used only the integral term O(int) with differing lower integration limits. Use of the incomplete heating rate could lead to erroneous conclusions regarding electron heat balance, since O(e) is greater than O(int) by as much as a factor of two

Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers.

Science.gov (United States)

Macias, Maria I; Grande, Jesús; Moreno, Ana; Domínguez, Irene; Bornstein, Rafael; Flores, Ana I

2010-11-01

The objective of the study was to isolate and characterize a population of mesenchymal stem cells (MSCs) from human term placental membranes. We isolated an adherent cell population from extraembryonic membranes. Morphology, phenotype, growth characteristics, karyotype, and immunological and differentiation properties were analyzed. The isolated placental MSCs were from maternal origin and named as decidua-derived mesenchymal stem cells (DMSCs). DMSCs differentiated into derivatives of all germ layers. It is the first report about placental MSC differentiation into alveolar type II cells. Clonally expanded DMSCs differentiated into all embryonic layers, including pulmonary cells. DMSCs showed higher life span than placental cells from fetal origin and proliferated without genomic instability. The data suggest that DMSCs are true multipotent MSCs, distinguishing them from other placental MSCs. DMSCs could be safely used in the mother as a potential source of MSCs for pelvic floor dysfunctions and immunological diseases. Additionally, frozen DMSCs can be stored for both autologous and allogeneic tissue regeneration. Copyright © 2010 Mosby, Inc. All rights reserved.

Symmetries, invariants and generating functions: higher-order statistics of biased tracers

Science.gov (United States)

Munshi, Dipak

2018-01-01

Gravitationally collapsed objects are known to be biased tracers of an underlying density contrast. Using symmetry arguments, generalised biasing schemes have recently been developed to relate the halo density contrast δh with the underlying density contrast δ, divergence of velocity θ and their higher-order derivatives. This is done by constructing invariants such as s, t, ψ,η. We show how the generating function formalism in Eulerian standard perturbation theory (SPT) can be used to show that many of the additional terms based on extended Galilean and Lifshitz symmetry actually do not make any contribution to the higher-order statistics of biased tracers. Other terms can also be drastically simplified allowing us to write the vertices associated with δh in terms of the vertices of δ and θ, the higher-order derivatives and the bias coefficients. We also compute the cumulant correlators (CCs) for two different tracer populations. These perturbative results are valid for tree-level contributions but at an arbitrary order. We also take into account the stochastic nature bias in our analysis. Extending previous results of a local polynomial model of bias, we express the one-point cumulants Script SN and their two-point counterparts, the CCs i.e. Script Cpq, of biased tracers in terms of that of their underlying density contrast counterparts. As a by-product of our calculation we also discuss the results using approximations based on Lagrangian perturbation theory (LPT).

Torsion and curvature in higher dimensional supergravity theories

International Nuclear Information System (INIS)

Smith, A.W.; Pontificia Univ. Catolica do Rio de Janeiro

1983-01-01

This work is an extension of Dragon's theorems to higher dimensional space-time. It is shown that the first set of Bianchi identities allow us to express the curvature components in terms of torsion components and its covariant derivatives. It is also shown that the second set of Bianchi identities does not give any new information which is not already contained in the first one. (Author) [pt

Preterm Cord Blood Contains a Higher Proportion of Immature Hematopoietic Progenitors Compared to Term Samples.

Science.gov (United States)

Podestà, Marina; Bruschettini, Matteo; Cossu, Claudia; Sabatini, Federica; Dagnino, Monica; Romantsik, Olga; Spaggiari, Grazia Maria; Ramenghi, Luca Antonio; Frassoni, Francesco

2015-01-01

Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8) vs 0.3% (0.032-2.23) p = 0.0001 and in neonates <32 weeks of gestational age (GA) compared to those ≥32 wks GA: 0.95% (range 0.18-4.8) and 0.36% (0.15-3.2) respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p<0.05 preterm vs term) and grew in vitro large BFU-E, mostly in the second generation. The subpopulations CD34+CD38- and CD34+CD45- resulted more represented in preterm samples compared to term, conversely, Side Population (SP) did not show any difference between the two group. The absolute number of preterm colonies (CFCs/10microL) resulted higher compared to term (p = 0.004) and these progenitors were able to grow until the third generation maintaining an higher proportion of CD34+ cells (p = 0.0017). The number of colony also inversely correlated with the gestational age (Pearson r = -0.3001 p<0.0168). We found no differences in the isolation and expansion capacity of Endothelial Colony Forming Cells (ECFCs) from cord blood of term and preterm neonates: both groups grew in vitro large number of endothelial cells until the third generation and showed a transitional phenotype between mesenchymal stem cells and endothelial progenitors (CD73, CD31, CD34 and CD144)The presence, in the cord blood of preterm babies, of high number of immature hematopoietic progenitors and endothelial/mesenchymal stem cells with high proliferative potential makes this tissue an important source of cells for developing new cells therapies.

Preterm Cord Blood Contains a Higher Proportion of Immature Hematopoietic Progenitors Compared to Term Samples.

Directory of Open Access Journals (Sweden)

Marina Podestà

Full Text Available Cord blood contains high number of hematopoietic cells that after birth disappear. In this paper we have studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups.Our results indicate that the percentage of total CD34+ cells was significantly higher in preterm infants compared to full term: 0.61% (range 0.15-4.8 vs 0.3% (0.032-2.23 p = 0.0001 and in neonates <32 weeks of gestational age (GA compared to those ≥32 wks GA: 0.95% (range 0.18-4.8 and 0.36% (0.15-3.2 respectively p = 0.0025. The majority of CD34+ cells co-expressed CD71 antigen (p<0.05 preterm vs term and grew in vitro large BFU-E, mostly in the second generation. The subpopulations CD34+CD38- and CD34+CD45- resulted more represented in preterm samples compared to term, conversely, Side Population (SP did not show any difference between the two group. The absolute number of preterm colonies (CFCs/10microL resulted higher compared to term (p = 0.004 and these progenitors were able to grow until the third generation maintaining an higher proportion of CD34+ cells (p = 0.0017. The number of colony also inversely correlated with the gestational age (Pearson r = -0.3001 p<0.0168.We found no differences in the isolation and expansion capacity of Endothelial Colony Forming Cells (ECFCs from cord blood of term and preterm neonates: both groups grew in vitro large number of endothelial cells until the third generation and showed a transitional phenotype between mesenchymal stem cells and endothelial progenitors (CD73, CD31, CD34 and CD144The presence, in the cord blood of preterm babies, of high number of immature hematopoietic progenitors and endothelial/mesenchymal stem cells with high proliferative potential makes this tissue an important source of cells for developing new cells therapies.

Constant curvature algebras and higher spin action generating functions

International Nuclear Information System (INIS)

Hallowell, K.; Waldron, A.

2005-01-01

The algebra of differential geometry operations on symmetric tensors over constant curvature manifolds forms a novel deformation of the sl(2,R)-bar R 2 Lie algebra. We present a simple calculus for calculations in its universal enveloping algebra. As an application, we derive generating functions for the actions and gauge invariances of massive, partially massless and massless (for both Bose and Fermi statistics) higher spins on constant curvature backgrounds. These are formulated in terms of a minimal set of covariant, unconstrained, fields rather than towers of auxiliary fields. Partially massless gauge transformations are shown to arise as degeneracies of the flat, massless gauge transformation in one dimension higher. Moreover, our results and calculus offer a considerable simplification over existing techniques for handling higher spins. In particular, we show how theories of arbitrary spin in dimension d can be rewritten in terms of a single scalar field in dimension 2d where the d additional dimensions correspond to coordinate differentials. We also develop an analogous framework for spinor-tensor fields in terms of the corresponding superalgebra

Higher-order Zeeman and spin terms in the electron paramagnetic resonance spin Hamiltonian; their description in irreducible form using Cartesian, tesseral spherical tensor and Stevens' operator expressions

International Nuclear Information System (INIS)

McGavin, Dennis G; Tennant, W Craighead

2009-01-01

In setting up a spin Hamiltonian (SH) to study high-spin Zeeman and high-spin nuclear and/or electronic interactions in electron paramagnetic resonance (EPR) experiments, it is argued that a maximally reduced SH (MRSH) framed in tesseral combinations of spherical tensor operators is necessary. Then, the SH contains only those terms that are necessary and sufficient to describe the particular spin system. The paper proceeds then to obtain interrelationships between the parameters of the MRSH and those of alternative SHs expressed in Cartesian tensor and Stevens operator-equivalent forms. The examples taken, initially, are those of Cartesian and Stevens' expressions for high-spin Zeeman terms of dimension BS 3 and BS 5 . Starting from the well-known decomposition of the general Cartesian tensor of second rank to three irreducible tensors of ranks 0, 1 and 2, the decomposition of Cartesian tensors of ranks 4 and 6 are treated similarly. Next, following a generalization of the tesseral spherical tensor equations, the interrelationships amongst the parameters of the three kinds of expressions, as derived from equivalent SHs, are determined and detailed tables, including all redundancy equations, set out. In each of these cases the lowest symmetry, 1-bar Laue class, is assumed and then examples of relationships for specific higher symmetries derived therefrom. The validity of a spin Hamiltonian containing mixtures of terms from the three expressions is considered in some detail for several specific symmetries, including again the lowest symmetry. Finally, we address the application of some of the relationships derived here to seldom-observed low-symmetry effects in EPR spectra, when high-spin electronic and nuclear interactions are present.

Fractional equivalent Lagrangian densities for a fractional higher-order equation

International Nuclear Information System (INIS)

Fujioka, J

2014-01-01

In this communication we show that the equivalent Lagrangian densities (ELDs) of a fractional higher-order nonlinear Schrödinger equation with stable soliton-like solutions can be related in a hitherto unknown way. This new relationship is described in terms of a new fractional operator that includes both left- and right-sided fractional derivatives. Using this operator it is possible to generate new ELDs that contain different fractional parts, in addition to the already known ELDs, which only differ by a sum of first-order partial derivatives of two arbitrary functions. (fast track communications)

Massive gravity with mass term in three dimensions

International Nuclear Information System (INIS)

Nakasone, Masashi; Oda, Ichiro

2009-01-01

We analyze the effect of the Pauli-Fierz mass term on a recently established, new massive gravity theory in three space-time dimensions. We show that the Pauli-Fierz mass term makes the new massive gravity theory nonunitary. Moreover, although we add the gravitational Chern-Simons term to this model, the situation remains unchanged and the theory stays nonunitary despite that the structure of the graviton propagator is greatly changed. Thus, the Pauli-Fierz mass term is not allowed to coexist with mass-generating higher-derivative terms in the new massive gravity.

Associations between Depressive State and Impaired Higher-Level Functional Capacity in the Elderly with Long-Term Care Requirements.

Science.gov (United States)

Ogata, Soshiro; Hayashi, Chisato; Sugiura, Keiko; Hayakawa, Kazuo

2015-01-01

Depressive state has been reported to be significantly associated with higher-level functional capacity among community-dwelling elderly. However, few studies have investigated the associations among people with long-term care requirements. We aimed to investigate the associations between depressive state and higher-level functional capacity and obtain marginal odds ratios using propensity score analyses in people with long-term care requirements. We conducted a cross-sectional study based on participants aged ≥ 65 years (n = 545) who were community dwelling and used outpatient care services for long-term preventive care. We measured higher-level functional capacity, depressive state, and possible confounders. Then, we estimated the marginal odds ratios (i.e., the change in odds of impaired higher-level functional capacity if all versus no participants were exposed to depressive state) by logistic models using generalized linear models with the inverse probability of treatment weighting (IPTW) for propensity score and design-based standard errors. Depressive state was used as the exposure variable and higher-level functional capacity as the outcome variable. The all absolute standardized differences after the IPTW using the propensity scores were functional capacity.

Term-time Employment and Student Attainment in Higher Education

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Cath Dennis

2018-04-01

Full Text Available The number of UK full-time university students engaging in term-time employment (TTE is rising. Students engaging in TTE have previously been found to achieve less well academically than those who do not. This study aimed to explore patterns of TTE and academic achievement of undergraduates at a large UK higher education institution. Self-reported TTE hours were matched to attainment data for 1304 undergraduate students in levels 1-4 of study (SQCF levels 7-10. The majority of students in TTE (71%, n=621 reported undertaking TTE to cover essential living expenses. Compared to students not undertaking TTE, attainment was significantly better at low levels of TTE (1-10 hours, and only significantly worse when TTE was >30 hours/week. This pattern was magnified when job type was taken into account – students employed in skilled roles for ≤10 hours/week on average attained grades 7% higher than those not in TTE; students working >10 hours/week in unskilled positions showed a mean 1.6% lower grade. The impact of ‘academic potential’ (measured via incoming UCAS tariff was accounted for in the model. The finding that students engaging in some categories of TTE achieve better academic outcomes than their non-employed peers is worthy of further investigation. This study is unable to provide direct evidence of possible causation, but would tentatively suggest that students may benefit from taking on 10 or fewer hours of TTE per week.

The Implications of Contractual Terms of Employment for Women and Leadership: An Autoethnographic Study in UK Higher Education

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Anne Vicary

2017-06-01

Full Text Available This article is concerned with the implications of casual, non-permanent forms of employment that have become a common cultural practice in higher education. It proposes that contractual terms of employment have important implications for women and leadership in higher education, since to pursue leadership, usually one must first gain permanency in an organization, in contractual terms. Based on an autoethnographic study by a female academic in a UK higher education institution, the article illustrates that temporary forms of employment, should they be protracted, can stifle leadership aspirations due to lack of career progression opportunities and lead to a sense of alienation from the target community of practice, and even to personal difficulties, such as feelings of isolation and poor self-esteem. The article discusses theoretical and practical implications for women’s leadership arising from the findings and makes recommendations for improvements in practice in the higher education sector. The findings and recommendations from this study will also be relevant to other organizational contexts where casual or temporary, fixed term, zero-hours non-permanent forms of employment are common.

Higher Regional Court Celle, judgment of December 9, 1986 (legal term of radioactive waste)

International Nuclear Information System (INIS)

Anon.

1987-01-01

In its decision of December 9, 1986, the Higher Regional Court in Celle deals with the legal term of radioactive waste. The definition does not result from sec. 1 para. 1 of the Waste Disposal Act but from sec. 9 a para. 1 Atomic Energy Act. (WG) [de

Promoting long-term survival of insulin-producing cell grafts that differentiate from adipose tissue-derived stem cells to cure type 1 diabetes.

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Shuzi Zhang

Full Text Available BACKGROUND: Insulin-producing cell clusters (IPCCs have recently been generated in vitro from adipose tissue-derived stem cells (ASCs to circumvent islet shortage. However, it is unknown how long they can survive upon transplantation, whether they are eventually rejected by recipients, and how their long-term survival can be induced to permanently cure type 1 diabetes. IPCC graft survival is critical for their clinical application and this issue must be systematically addressed prior to their in-depth clinical trials. METHODOLOGY/PRINCIPAL FINDINGS: Here we found that IPCC grafts that differentiated from murine ASCs in vitro, unlike their freshly isolated islet counterparts, did not survive long-term in syngeneic mice, suggesting that ASC-derived IPCCs have intrinsic survival disadvantage over freshly isolated islets. Indeed, β cells retrieved from IPCC syngrafts underwent faster apoptosis than their islet counterparts. However, blocking both Fas and TNF receptor death pathways inhibited their apoptosis and restored their long-term survival in syngeneic recipients. Furthermore, blocking CD40-CD154 costimulation and Fas/TNF signaling induced long-term IPCC allograft survival in overwhelming majority of recipients. Importantly, Fas-deficient IPCC allografts exhibited certain immune privilege and enjoyed long-term survival in diabetic NOD mice in the presence of CD28/CD40 joint blockade while their islet counterparts failed to do so. CONCLUSIONS/SIGNIFICANCE: Long-term survival of ASC-derived IPCC syngeneic grafts requires blocking Fas and TNF death pathways, whereas blocking both death pathways and CD28/CD40 costimulation is needed for long-term IPCC allograft survival in diabetic NOD mice. Our studies have important clinical implications for treating type 1 diabetes via ASC-derived IPCC transplantation.

On mixed derivatives type high dimensional multi-term fractional partial differential equations approximate solutions

Science.gov (United States)

Talib, Imran; Belgacem, Fethi Bin Muhammad; Asif, Naseer Ahmad; Khalil, Hammad

2017-01-01

In this research article, we derive and analyze an efficient spectral method based on the operational matrices of three dimensional orthogonal Jacobi polynomials to solve numerically the mixed partial derivatives type multi-terms high dimensions generalized class of fractional order partial differential equations. We transform the considered fractional order problem to an easily solvable algebraic equations with the aid of the operational matrices. Being easily solvable, the associated algebraic system leads to finding the solution of the problem. Some test problems are considered to confirm the accuracy and validity of the proposed numerical method. The convergence of the method is ensured by comparing our Matlab software simulations based obtained results with the exact solutions in the literature, yielding negligible errors. Moreover, comparative results discussed in the literature are extended and improved in this study.

Higher-spin flat space cosmologies with soft hair

Energy Technology Data Exchange (ETDEWEB)

Ammon, Martin [Theoretisch-Physikalisches Institut, Friedrich-Schiller University of Jena, Max-Wien-Platz 1, D-07743 Jena (Germany); Grumiller, Daniel [Institute for Theoretical Physics, TU Wien, Wiedner Hauptstrasse 8-10/136, A-1040 Vienna (Austria); CMCC-Universidade Federal do ABC,Santo André, S.P. (Brazil); Prohazka, Stefan [Institute for Theoretical Physics, TU Wien, Wiedner Hauptstrasse 8-10/136, A-1040 Vienna (Austria); Riegler, Max [Université libre de Bruxelles, Boulevard du Triomphe, Campus de la Plaine,1050 Bruxelles (Belgium); Wutte, Raphaela [Institute for Theoretical Physics, TU Wien, Wiedner Hauptstrasse 8-10/136, A-1040 Vienna (Austria)

2017-05-08

We present and discuss near horizon boundary conditions for flat space higher-spin gravity in three dimensions. As in related work our boundary conditions ensure regularity of the solutions independently of the charges. The asymptotic symmetry algebra is given by a set of û(1) current algebras. The associated charges generate higher-spin soft hair. We derive the entropy for solutions that are continuously connected to flat space cosmologies and find the same result as in the spin-2 case: the entropy is linear in the spin-2 zero-mode charges and independent from the spin-3 charges. Using twisted Sugawara-like constructions of higher-spin currents we show that our simple result for entropy of higher-spin flat space cosmologies coincides precisely with the complicated earlier results expressed in terms of higher-spin zero mode charges.

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.

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Anjie Zhen

2017-12-01

Full Text Available Chimeric Antigen Receptor (CAR T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may reappear months or years after treatment remains unclear. Hematopoietic Stem/Progenitor Cells (HSPCs are capable of long-term engraftment and have the potential to overcome these limitations. Here, we report the use of a protective CD4 chimeric antigen receptor (C46CD4CAR to redirect HSPC-derived T-cells against simian/human immunodeficiency virus (SHIV infection in pigtail macaques. CAR-containing cells persisted for more than 2 years without any measurable toxicity and were capable of multilineage engraftment. Combination antiretroviral therapy (cART treatment followed by cART withdrawal resulted in lower viral rebound in CAR animals relative to controls, and demonstrated an immune memory-like response. We found CAR-expressing cells in multiple lymphoid tissues, decreased tissue-associated SHIV RNA levels, and substantially higher CD4/CD8 ratios in the gut as compared to controls. These results show that HSPC-derived CAR T-cells are capable of long-term engraftment and immune surveillance. This study demonstrates for the first time the safety and feasibility of HSPC-based CAR therapy in a large animal preclinical model.

Synthesis and antimicrobial activities of new higher amino acid Schiff base derivatives of 6-aminopenicillanic acid and 7-aminocephalosporanic acid

Science.gov (United States)

Özdemir (nee Güngör), Özlem; Gürkan, Perihan; Özçelik, Berrin; Oyardı, Özlem

2016-02-01

Novel β-lactam derivatives (1c-3c) (1d-3d) were produced by using 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and the higher amino acid Schiff bases. The synthesized compounds were characterized by elemental analysis, IR, 1H/13C NMR and UV-vis spectra. Antibacterial activities of all the higher amino acid Schiff bases (1a-3a) (1b-3b) and β-lactam derivatives were screened against three gram negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii RSKK 02026), three gram positive bacteria (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 07005, Bacillus subtilis ATCC 6633) and their drug-resistant isolates by using broth microdilution method. Two fungi (Candida albicans and Candida krusei) were used for antifungal activity.

Boundary terms in the Nambu-Goto string action

Science.gov (United States)

Hadasz, Leszek; Wȩgrzyn, Paweł

1995-03-01

We investigate classical strings defined by the Nambu-Goto action with the boundary term added. We demonstrate that the latter term has a significant bearing on the string dynamics. It is confirmed that new action terms that depend on higher order derivatives of string coordinates cannot be considered as continuous perturbations from the starting string functional. In the case when the boundary term reduces to the Gauss-Bonnet term, a stability analysis is performed on the rotating rigid string solution. We determine the most generic solution that the fluctuations grow to. Longitudinal string excitations are found. The Regge trajectories are nonlinear.

Boundary terms in the Nambu-Goto string action

International Nuclear Information System (INIS)

Hadasz, L.; Wegrzyn, P.

1995-01-01

We investigate classical strings defined by the Nambu-Goto action with the boundary term added. We demonstrate that the latter term has a significant bearing on the string dynamics. It is confirmed that new action terms that depend on higher order derivatives of string coordinates cannot be considered as continuous perturbations from the starting string functional. In the case when the boundary term reduces to the Gauss-Bonnet term, a stability analysis is performed on the rotating rigid string solution. We determine the most generic solution that the fluctuations grow to. Longitudinal string excitations are found. The Regge trajectories are nonlinear

Higher-order gravity in higher dimensions: geometrical origins of four-dimensional cosmology?

Energy Technology Data Exchange (ETDEWEB)

Troisi, Antonio [Universita degli Studi di Salerno, Dipartimento di Fisica ' ' E.R. Caianiello' ' , Salerno (Italy)

2017-03-15

Determining the cosmological field equations is still very much debated and led to a wide discussion around different theoretical proposals. A suitable conceptual scheme could be represented by gravity models that naturally generalize Einstein theory like higher-order gravity theories and higher-dimensional ones. Both of these two different approaches allow one to define, at the effective level, Einstein field equations equipped with source-like energy-momentum tensors of geometrical origin. In this paper, the possibility is discussed to develop a five-dimensional fourth-order gravity model whose lower-dimensional reduction could provide an interpretation of cosmological four-dimensional matter-energy components. We describe the basic concepts of the model, the complete field equations formalism and the 5-D to 4-D reduction procedure. Five-dimensional f(R) field equations turn out to be equivalent, on the four-dimensional hypersurfaces orthogonal to the extra coordinate, to an Einstein-like cosmological model with three matter-energy tensors related with higher derivative and higher-dimensional counter-terms. By considering the gravity model with f(R) = f{sub 0}R{sup n} the possibility is investigated to obtain five-dimensional power law solutions. The effective four-dimensional picture and the behaviour of the geometrically induced sources are finally outlined in correspondence to simple cases of such higher-dimensional solutions. (orig.)

Derivation of the source term, dose results and associated radiological consequences for the Greek Research Reactor – 1

Energy Technology Data Exchange (ETDEWEB)

Pappas, Charalampos, E-mail: chpappas@ipta.demokritos.gr; Ikonomopoulos, Andreas; Sfetsos, Athanasios; Andronopoulos, Spyros; Varvayanni, Melpomeni; Catsaros, Nicolas

2014-07-01

Highlights: • Source term derivation of postulated accident sequences in a research reactor. • Various containment ventilation scenarios considered for source term calculations. • Source term parametric analysis performed in case of lack of ventilation. • JRODOS employed for dose calculations under eighteen modeled scenarios. • Estimation of radiological consequences during typical and adverse weather scenarios. - Abstract: The estimated source term, dose results and radiological consequences of selected accident sequences in the Greek Research Reactor – 1 are presented and discussed. A systematic approach has been adopted to perform the necessary calculations in accordance with the latest computational developments and IAEA recommendations. Loss-of-coolant, reactivity insertion and fuel channel blockage accident sequences have been selected to derive the associated source terms under three distinct containment ventilation scenarios. Core damage has been conservatively assessed for each accident sequence while the ventilation has been assumed to function within the efficiency limits defined at the Safety Analysis Report. In case of lack of ventilation a parametric analysis is also performed to examine the dependency of the source term on the containment leakage rate. A typical as well as an adverse meteorological scenario have been defined in the JRODOS computational platform in order to predict the effective, lung and thyroid doses within a region defined by a 15 km radius downwind from the reactor building. The radiological consequences of the eighteen scenarios associated with the accident sequences are presented and discussed.

THE TERMS OF INHERITANCE LAW IN RUSSIA-BYZANTIUM TREATIES AND RUSSKAYA PRAVDA: THE PROBLEMS OF FUNCTIONAL SEMANTICS AND DERIVATION RELATIONS

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Kirzhaeva Vera Petrovna

2014-12-01

Full Text Available The article deals with the functional-and-semantic and derivational relations of the inheritance law terms in the Russia-Byzantium treaties and in Russkaya Pravda Legal Code as well as in the wide-spread Church Slavonic law regulators that appeared in Rus after adoption of Christianity. The research results attest that the inheritance law terminology in treaties includes designation of inheritance, will and heirs. There is a special term chast ('part' that denotes a share of inheritance in the Russkaya Pravda and Church Slavonic legal texts. However, chast as a 'part' (share is a characteristic of the Russkaya Pravda legal texts only. In Church Slavonic it is used in treaties for nominating the property in general. A similar lack of strict distribution between inheritance law terms zadnitsa and dom, presented in Old Russian texts, was noted in Church Slavonic treaties. Various derivatives of the root *rÌd- are used to denote the will in all texts under analysis; the terms pisati employed only in treaties and church law regulators to denote a written will or procedures of its preparation. The derivatives of the root *bliz- nominate the heirs in both text systems. A loan translation of the terminological word group malye / milye blizhnie / blizhiki dated to the year 911 is not viewed as a translators' experiment with the Greek terms, because it reflects a steady lexical distribution of adjectives malye / milye and the terms of relations in the Russian language. The results of the study testify some inheritance law terms correlation between Russia-Byzantium treaties, Russkaya Pravda and Church Slavonic legal texts, their translation in the treaties was not entirely artificial. The Church Slavonic and Old Russian terminological systems were open to these interferences in some ways.

Long term weight maintenance after advice to consume low carbohydrate, higher protein diets--a systematic review and meta analysis.

Science.gov (United States)

Clifton, P M; Condo, D; Keogh, J B

2014-03-01

Meta analysis of short term trials indicates that a higher protein, lower carbohydrate weight loss diet enhances fat mass loss and limits lean mass loss compared with a normal protein weight loss diet. Whether this benefit persists long term is not clear. We selected weight loss studies in adults with at least a 12 month follow up in which a higher percentage protein/lower carbohydrate diet was either planned or would be expected for either weight loss or weight maintenance. Studies were selected regardless of the success of the advice but difference in absolute and percentage protein intake at 12 months was used as a moderator in the analysis. Data was analysed using Comprehensive Meta analysis V2 using a random effects analysis. As many as 32 studies with 3492 individuals were analysed with data on fat and lean mass, glucose and insulin from 18 to 22 studies and lipids from 28 studies. A recommendation to consume a lower carbohydrate, higher protein diet in mostly short term intensive interventions with long term follow up was associated with better weight and fat loss but the effect size was small-standardised means of 0.14 and 0.22, p = 0.008 and p fat mass (0.9 vs. 0.3 kg). Fasting triglyceride and insulin were also lower with high protein diets with effect sizes of 0.17 and 0.22, p = 0.003 and p = 0.042 respectively. Other lipids and glucose were not different. The short term benefit of higher protein diets appears to persist to a small degree long term. Benefits are greater with better compliance to the diet. Copyright © 2013 Elsevier B.V. All rights reserved.

S-duality constraint on higher-derivative couplings

International Nuclear Information System (INIS)

Garousi, Mohammad R.

2014-01-01

The Riemann curvature correction to the type II supergravity at eight-derivative level in string frame is given as e"−"2"ϕ(t_8t_8R"4+(1/4)ϵ_8ϵ_8R"4). For constant dilaton, it has been extended in the literature to the S-duality invariant form by extending the dilaton factor in the Einstein frame to the non-holomorphic Eisenstein series. For non-constant dilaton, however, there are various couplings in the Einstein frame which are not consistent with the S-duality. By constructing the tensors t_2_n from Born-Infeld action, we include the appropriate Ricci and scalar curvatures as well as the dilaton couplings to make the above action to be consistent with the S-duality

S-duality constraint on higher-derivative couplings

Energy Technology Data Exchange (ETDEWEB)

Garousi, Mohammad R. [Department of Physics, Ferdowsi University of Mashhad,P.O. Box 1436, Mashhad (Iran, Islamic Republic of)

2014-05-22

The Riemann curvature correction to the type II supergravity at eight-derivative level in string frame is given as e{sup −2ϕ}(t{sub 8}t{sub 8}R{sup 4}+(1/4)ϵ{sub 8}ϵ{sub 8}R{sup 4}). For constant dilaton, it has been extended in the literature to the S-duality invariant form by extending the dilaton factor in the Einstein frame to the non-holomorphic Eisenstein series. For non-constant dilaton, however, there are various couplings in the Einstein frame which are not consistent with the S-duality. By constructing the tensors t{sub 2n} from Born-Infeld action, we include the appropriate Ricci and scalar curvatures as well as the dilaton couplings to make the above action to be consistent with the S-duality.

Higher covariant derivative Pauli-Villars regularization does not lead to a consistent QCD

Energy Technology Data Exchange (ETDEWEB)

Martin, C P [Universidad Autonoma de Madrid (Spain). Dept. de Fisica Teorica; Ruiz Ruiz, F [Nationaal Inst. voor Kernfysica en Hoge-Energiefysica (NIKHEF), Amsterdam (Netherlands). Sectie H

1994-12-31

We compute the beta function at one loop for Yang-Mills theory using as regulator the combination of higher covariant derivatives and Pauli-Villars determinants proposed by Faddeev and Slavnov. This regularization prescription has the appealing feature that it is manifestly gauge invariant and essentially four-dimensional. It happens however that the one-loop coefficient in the beta function that it yields is not -11/3, as it should be, but -23/6. The difference is due to unphysical logarithmic radiative corrections generated by the Pauli-Villars determinants on which the regularization method is based. This no-go result discards the prescription as a viable gauge invariant regularization, thus solving a long-standing open question in the literature. We also observe that the precsription can be modified so as to not generate unphysical logarithmic corrections, but at the expense of losing manifest gauge invariance. (orig.).

Higher covariant derivative Pauli-Villars regularization does not lead to a consistent QCD

International Nuclear Information System (INIS)

Martin, C.P.; Ruiz Ruiz, F.

1994-01-01

We compute the beta function at one loop for Yang-Mills theory using as regulator the combination of higher covariant derivatives and Pauli-Villars determinants proposed by Faddeev and Slavnov. This regularization prescription has the appealing feature that it is manifestly gauge invariant and essentially four-dimensional. It happens however that the one-loop coefficient in the beta function that it yields is not -11/3, as it should be, but -23/6. The difference is due to unphysical logarithmic radiative corrections generated by the Pauli-Villars determinants on which the regularization method is based. This no-go result discards the prescription as a viable gauge invariant regularization, thus solving a long-standing open question in the literature. We also observe that the precsription can be modified so as to not generate unphysical logarithmic corrections, but at the expense of losing manifest gauge invariance. (orig.)

Medical Underwriting In Long-Term Care Insurance: Market Conditions Limit Options For Higher-Risk Consumers.

Science.gov (United States)

Cornell, Portia Y; Grabowski, David C; Cohen, Marc; Shi, Xiaomei; Stevenson, David G

2016-08-01

A key feature of private long-term care insurance is that medical underwriters screen out would-be buyers who have health conditions that portend near-term physical or cognitive disability. We applied common underwriting criteria based on data from two long-term care insurers to a nationally representative sample of individuals in the target age range (50-71 years) for long-term care insurance. The screening criteria put upper bounds on the current proportion of Americans who could gain coverage in the individual market without changes to medical underwriting practice. Specifically, our simulations show that in the target age range, approximately 30 percent of those whose wealth meets minimum industry standards for suitability for long-term care insurance would have their application for such insurance rejected at the underwriting stage. Among the general population-without considering financial suitability-we estimated that 40 percent would have their applications rejected. The predicted rejection rates are substantially higher than the rejection rates of about 20-25 percent of applicants in the actual market. In evaluating reforms for long-term care financing and their potential to increase private insurance rates, as well as to reduce financial pressure on public safety-net programs, policy makers need to consider the role of underwriting in the market for long-term care insurance. Project HOPE—The People-to-People Health Foundation, Inc.

Beyond Lovelock gravity: Higher derivative metric theories

Science.gov (United States)

Crisostomi, M.; Noui, K.; Charmousis, C.; Langlois, D.

2018-02-01

We consider theories describing the dynamics of a four-dimensional metric, whose Lagrangian is diffeomorphism invariant and depends at most on second derivatives of the metric. Imposing degeneracy conditions we find a set of Lagrangians that, apart form the Einstein-Hilbert one, are either trivial or contain more than 2 degrees of freedom. Among the partially degenerate theories, we recover Chern-Simons gravity, endowed with constraints whose structure suggests the presence of instabilities. Then, we enlarge the class of parity violating theories of gravity by introducing new "chiral scalar-tensor theories." Although they all raise the same concern as Chern-Simons gravity, they can nevertheless make sense as low energy effective field theories or, by restricting them to the unitary gauge (where the scalar field is uniform), as Lorentz breaking theories with a parity violating sector.

Higher time derivatives of the generalized Liapunov function

International Nuclear Information System (INIS)

Schieve, W.C.; Bulsara, A.R.

1975-01-01

Using the generalized N-body expression for a Liapunov functional developed by Prigogine and coworkers, a condition is obtained whereby the successive time derivatives of this function alternate in sign for weakly coupled systems. This generalized Liapunov function contains contributions from the diagonal as well as off-diagonal (correlation) components of the density matrix. The alternating sign condition is applied (and seen to hold true) for the cases of elastic phonon scattering in a lattice, three-phonon scattering (the anharmonic lattice), and the quantum electron gas. It is also proved simply for the Friedrichs model

Mixed Higher Order Variational Model for Image Recovery

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Pengfei Liu

2014-01-01

Full Text Available A novel mixed higher order regularizer involving the first and second degree image derivatives is proposed in this paper. Using spectral decomposition, we reformulate the new regularizer as a weighted L1-L2 mixed norm of image derivatives. Due to the equivalent formulation of the proposed regularizer, an efficient fast projected gradient algorithm combined with monotone fast iterative shrinkage thresholding, called, FPG-MFISTA, is designed to solve the resulting variational image recovery problems under majorization-minimization framework. Finally, we demonstrate the effectiveness of the proposed regularization scheme by the experimental comparisons with total variation (TV scheme, nonlocal TV scheme, and current second degree methods. Specifically, the proposed approach achieves better results than related state-of-the-art methods in terms of peak signal to ratio (PSNR and restoration quality.

Electrophysiological correlates of higher states of consciousness during sleep in long-term practitioners of the Transcendental Meditation program.

Science.gov (United States)

Mason, L I; Alexander, C N; Travis, F T; Marsh, G; Orme-Johnson, D W; Gackenbach, J; Mason, D C; Rainforth, M; Walton, K G

1997-02-01

Standard ambulatory night sleep electroencephalograph (EEG) of 11 long-term practitioners of the Transcendental Meditation (TM) program reporting "higher states of consciousness" during sleep (the experimental group) was compared to that of nine short-term practitioners and 11 non-practitioners. EEG tracings during stages 3 and 4 sleep showed the experimental group to have: 1) theta-alpha activity simultaneously with delta activity and 2) decreased chin electromyograph (EMG) during deep sleep (p = 0.002) compared to short-term practitioners. Spectral analysis fast Fourier transform (FFT) data of the first three cycles showed that: 3) the experimental subjects had significantly greater theta 2 (6-8 Hz)-alpha 1 (8-10 Hz) relative power during stages 3 and 4 than the combined control groups [t(30) = 5.5, p = 0.0000008] with no difference in time in delta; 4) there was a graded difference across groups during stages 3 and 4 in theta 2-alpha 1 power, with experimentals having greater power than short-term practitioners, who in turn had greater power than non-practitioners [t(30) = 5.08, p = 0.00002]; and 5) experimentals also had increased rapid eye movement (REM) density during REM periods compared to short-term practitioners (p = 0.04). Previous studies have found increased theta-alpha EEG activity during reported periods of "transcendental consciousness" during the TM technique. In the Vedic tradition, as described by Maharishi Mahesh Yogi, transcendental consciousness is the first of a sequence of higher states. The maintenance of transcendental consciousness along with deep sleep is said to be a distinctive criterion of further, stabilized higher states of consciousness. The findings of this study are interpreted as physiological support for this model.

Integrable higher order deformations of Heisenberg supermagnetic model

International Nuclear Information System (INIS)

Guo Jiafeng; Yan Zhaowen; Wang Shikun; Wu Ke; Zhao Weizhong

2009-01-01

The Heisenberg supermagnet model is an integrable supersymmetric system and has a close relationship with the strong electron correlated Hubbard model. In this paper, we investigate the integrable higher order deformations of Heisenberg supermagnet models with two different constraints: (i) S 2 =3S-2I for S is an element of USPL(2/1)/S(U(2)xU(1)) and (ii) S 2 =S for S is an element of USPL(2/1)/S(L(1/1)xU(1)). In terms of the gauge transformation, their corresponding gauge equivalent counterparts are derived.

Nonanaplastic follicular cell-derived thyroid carcinoma: mitosis and necrosis in long-term follow-up.

Science.gov (United States)

Skansing, Daniel Bräuner; Londero, Stefano Christian; Asschenfeldt, Pia; Larsen, Stine Rosenkilde; Godballe, Christian

2017-06-01

Nonanaplastic follicular cell-derived thyroid carcinoma (NAFCTC) includes differentiated- (DTC) and poorly differentiated thyroid carcinoma (PDTC). DTC has an excellent prognosis, while PDTC is situated between DTC and anaplastic carcinomas. Short-term studies suggest that PDTC patients diagnosed only on tumor necrosis and/or mitosis have a prognosis similar to those diagnosed according to the TURIN proposal. The purpose of this study was to evaluate prognosis for NAFCTC based on long-term follow-up illuminating the significance of tumor necrosis and mitosis. A cohort of 225 patients with NAFCTC was followed more than 20 years. Age, sex, distant metastasis, histology, tumor size, extrathyroidal invasion, lymph node metastasis, tumor necrosis and mitosis were examined as possible prognostic factors. Median follow-up time for patients alive was 28 years (range 20-43 years). Age, distant metastasis, extrathyroidal invasion, tumor size, tumor necrosis and mitosis were independent prognostic factors in multivariate analysis for overall survival (OS). In disease specific survival (DSS) age was not significant. Using only necrosis and/or mitosis as criteria for PDTC the 5-, 10- and 20-year OS for DTC was 87, 79 and 69%, respectively. In DSS it was 95, 92 and 90%. For PDTC the 5-, 10- and 20-year OS was 57, 40 and 25%, respectively. In DSS it was 71, 55 and 48%. Tumor necrosis and mitosis are highly significant prognostic indicators in analysis of long time survival of nonanaplastic follicular cell-derived thyroid carcinoma indicating that a simplification of the actually used criteria for poorly differentiated carcinomas may be justified.

MATLAB-based algorithm to estimate depths of isolated thin dike-like sources using higher-order horizontal derivatives of magnetic anomalies.

Science.gov (United States)

Ekinci, Yunus Levent

2016-01-01

This paper presents an easy-to-use open source computer algorithm (code) for estimating the depths of isolated single thin dike-like source bodies by using numerical second-, third-, and fourth-order horizontal derivatives computed from observed magnetic anomalies. The approach does not require a priori information and uses some filters of successive graticule spacings. The computed higher-order horizontal derivative datasets are used to solve nonlinear equations for depth determination. The solutions are independent from the magnetization and ambient field directions. The practical usability of the developed code, designed in MATLAB R2012b (MathWorks Inc.), was successfully examined using some synthetic simulations with and without noise. The algorithm was then used to estimate the depths of some ore bodies buried in different regions (USA, Sweden, and Canada). Real data tests clearly indicated that the obtained depths are in good agreement with those of previous studies and drilling information. Additionally, a state-of-the-art inversion scheme based on particle swarm optimization produced comparable results to those of the higher-order horizontal derivative analyses in both synthetic and real anomaly cases. Accordingly, the proposed code is verified to be useful in interpreting isolated single thin dike-like magnetized bodies and may be an alternative processing technique. The open source code can be easily modified and adapted to suit the benefits of other researchers.

Evaluating short-term hydro-meteorological fluxes using GRACE-derived water storage changes

Science.gov (United States)

Eicker, A.; Jensen, L.; Springer, A.; Kusche, J.

2017-12-01

Atmospheric and terrestrial water budgets, which represent important boundary conditions for both climate modeling and hydrological studies, are linked by evapotranspiration (E) and precipitation (P). These fields are provided by numerical weather prediction models and atmospheric reanalyses such as ERA-Interim and MERRA-Land; yet, in particular the quality of E is still not well evaluated. Via the terrestrial water budget equation, water storage changes derived from products of the Gravity Recovery and Climate Experiment (GRACE) mission, combined with runoff (R) data can be used to assess the realism of atmospheric models. In this contribution we will investigate the closure of the water balance for short-term fluxes, i.e. the agreement of GRACE water storage changes with P-E-R flux time series from different (global and regional) atmospheric reanalyses, land surface models, as well as observation-based data sets. Missing river runoff observations will be extrapolated using the calibrated rainfall-runoff model GR2M. We will perform a global analysis and will additionally focus on selected river basins in West Africa. The investigations will be carried out for various temporal scales, focusing on short-term fluxes down to daily variations to be detected in daily GRACE time series.

Existence and Solution-representation of IVP for LFDE with Generalized Riemann-Liouville fractional derivatives and $n$ terms

OpenAIRE

Kim, Myong-Ha; Ri, Guk-Chol; O, Hyong-Chol

2013-01-01

This paper provides the existence and representation of solution to an initial value problem for the general multi-term linear fractional differential equation with generalized Riemann-Liouville fractional derivatives and constant coefficients by using operational calculus of Mikusinski's type. We prove that the initial value problem has the solution of if and only if some initial values should be zero.

Higher order BLG supersymmetry transformations from 10-dimensional super Yang Mills

Energy Technology Data Exchange (ETDEWEB)

Hall, John [Alumnus of Physics Department, Imperial College,South Kensington, London, SW7 2AZ (United Kingdom); Low, Andrew [Physics Department, Wimbledon High School,Mansel Road, London, SW19 4AB (United Kingdom)

2014-06-26

We study a Simple Route for constructing the higher order Bagger-Lambert-Gustavsson theory - both supersymmetry transformations and Lagrangian - starting from knowledge of only the 10-dimensional Super Yang Mills Fermion Supersymmetry transformation. We are able to uniquely determine the four-derivative order corrected supersymmetry transformations, to lowest non-trivial order in Fermions, for the most general three-algebra theory. For the special case of Euclidean three-algbera, we reproduce the result presented in arXiv:1207.1208, with significantly less labour. In addition, we apply our method to calculate the quadratic fermion terms in the higher order BLG fermion supersymmetry transformation.

Dipole term and first derivative at K=0 of the generalized oscillator strength of He by keV electron impact

International Nuclear Information System (INIS)

Backx, C.; Tol, R.R.; Wight, G.R.; Wiel, M.J. van der

1975-01-01

An approximate method is described for obtaining the derivative to K 2 of the generalized oscillator strength for keV electron scattering at zero momentum transfer, over a large range of energy losses. The measured data enable the reduction of the systematical uncertainty in the derivation of optical oscillator strengths to below 1%. Results are presented for He over the spectral range of 19 to 65 eV. The data for the derivation are in satisfactory agreement with earlier electron scattering results at lower impact energy and extend over a sufficient range to allow the application of a sum rule for this term of the generalized oscillator strength. (Auth.)

Generation of higher derivatives operators and electromagnetic wave propagation in a Lorentz-violation scenario

Energy Technology Data Exchange (ETDEWEB)

Borges, L.H.C., E-mail: luizhenriqueunifei@yahoo.com.br [Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, Av. dos Estados, 5001, Santo André, SP, 09210-580 (Brazil); Dias, A.G., E-mail: alex.dias@ufabc.edu.br [Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, Av. dos Estados, 5001, Santo André, SP, 09210-580 (Brazil); Ferrari, A.F., E-mail: alysson.ferrari@ufabc.edu.br [Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, Av. dos Estados, 5001, Santo André, SP, 09210-580 (Brazil); Nascimento, J.R., E-mail: jroberto@fisica.ufpb.br [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, João Pessoa, Paraíba, 58051-970 (Brazil); Petrov, A.Yu., E-mail: petrov@fisica.ufpb.br [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, João Pessoa, Paraíba, 58051-970 (Brazil)

2016-05-10

We study the perturbative generation of higher-derivative Lorentz violating operators as quantum corrections to the photon effective action, originated from a specific Lorentz violation background, which has already been studied in connection with the physics of light pseudoscalars. We calculate the complete one loop effective action of the photon field through the proper-time method, using the zeta function regularization. This result can be used as a starting point to study possible effects of the Lorentz violating background we are considering in photon physics. As an example, we focus on the lowest order corrections and investigate whether they could influence the propagation of electromagnetic waves through the vacuum. We show, however, that no effects of the kind of Lorentz violation we consider can be detected in such a context, so that other aspects of photon physics have to be studied.

Radiative generation of the CPT-even gauge term of the SME from a dimension-five nonminimal coupling term

Energy Technology Data Exchange (ETDEWEB)

Casana, R., E-mail: rodolfo.casana@gmail.com [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil); Ferreira, M.M., E-mail: manojr07@ibest.com.br [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil); Maluf, R.V., E-mail: robertovinhaes@fisica.ufc.br [Universidade Federal do Ceará (UFC), Departamento de Física, Campus do Pici, Fortaleza, CE, C.P. 6030, 60455-760 (Brazil); Santos, F.E.P. dos, E-mail: fredegol@ibest.com.br [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil)

2013-11-04

In this Letter we show for the first time that the usual CPT-even gauge term of the Standard Model Extension (SME), in its full structure, can be radiatively generated, in a gauge invariant level, in the context of a modified QED endowed with a dimension-five nonminimal coupling term recently proposed in the literature. As a consequence, the existing upper bounds on the coefficients of the tensor (K{sub F}) can be used to improve the bounds on the magnitude of the nonminimal coupling, λ(K{sub σF}), by the factors 10{sup 5} or 10{sup 25}. The nonminimal coupling also generates higher-order derivative contributions to the gauge field effective action quadratic terms.

Ghost problem of quantum field theories with higher derivatives

International Nuclear Information System (INIS)

Gavrielides, A.; Kuo, T.K.; Lee, S.Y.

1976-01-01

Second-order theories, i.e., theories described by Lagrangians quadratic in second derivatives of the fields, are carefully examined and their ghost problems are isolated and clearly exhibited. In particular, theories with gauge symmetry are shown to have precisely the same ghost problems as theories without gauge symmetry. It is also shown that massless theories of the same nature are the limit of massive theories containing ghost states

C{sub T} for non-unitary CFTs in higher dimensions

Energy Technology Data Exchange (ETDEWEB)

Osborn, Hugh [Department of Applied Mathematics and Theoretical Physics, Wilberforce Road,Cambridge CB3 0WA, England (United Kingdom); Stergiou, Andreas [Department of Physics, Yale University,New Haven, CT 06520 (United States)

2016-06-13

The coefficient C{sub T} of the conformal energy-momentum tensor two-point function is determined for the non-unitary scalar CFTs with four- and six-derivative kinetic terms. The results match those expected from large-N calculations for the CFTs arising from the O(N) non-linear sigma and Gross-Neveu models in specific even dimensions. C{sub T} is also calculated for the CFT arising from (n−1)-form gauge fields with derivatives in 2n+2 dimensions. Results for (n−1)-form theory extended to general dimensions as a non-gauge-invariant CFT are also obtained; the resulting C{sub T} differs from that for the gauge-invariant theory. The construction of conformal primaries by subtracting descendants of lower-dimension primaries is also discussed. For free theories this also leads to an alternative construction of the energy-momentum tensor, which can be quite involved for higher-derivative theories.

Heterogenic expression of stem cell markers in patient-derived glioblastoma spheroid cultures exposed to long-term hypoxia

DEFF Research Database (Denmark)

Rosenberg, Tine; Aaberg-Jessen, Charlotte; Petterson, Stine Asferg

2018-01-01

AIM: To investigate the time profile of hypoxia and stem cell markers in glioblastoma spheroids of known molecular subtype. MATERIALS & METHODS: Patient-derived glioblastoma spheroids were cultured up to 7 days in either 2% or 21% oxygen. Levels of proliferation (Ki-67), hypoxia (HIF-1α, CA9...... and VEGF) and stem cell markers (CD133, nestin and musashi-1) were investigated by immunohistochemistry. RESULTS: Hypoxia markers as well as CD133 and partially nestin increased in long-term hypoxia. The proliferation rate and spheroid size were highest in normoxia. CONCLUSION: We found differences...... in hypoxia and stem cell marker profiles between the patient-derived glioblastoma cultures. This heterogeneity should be taken into consideration in development of future therapeutic strategies....

Financial Derivatives

OpenAIRE

Janečková, Alena

2011-01-01

1 Abstract/ Financial derivatives The purpose of this thesis is to provide an introduction to financial derivatives which has been, from the legal perspective, described in a not satisfactory manner as quite little literature that can be found about this topic. The main objectives of this thesis are to define the term "financial derivatives" and its particular types and to analyse legal nature of these financial instruments. The last objective is to try to draft future law regulation of finan...

Towards a resolution of the cosmological singularity in non-local higher derivative theories of gravity

International Nuclear Information System (INIS)

Biswas, Tirthabir; Koivisto, Tomi; Mazumdar, Anupam

2010-01-01

One of the greatest problems of standard cosmology is the Big Bang singularity. Previously it has been shown that non-local ghostfree higher-derivative modifications of Einstein gravity in the ultra-violet regime can admit non-singular bouncing solutions. In this paper we study in more details the dynamical properties of the equations of motion for these theories of gravity in presence of positive and negative cosmological constants and radiation. We find stable inflationary attractor solutions in the presence of a positive cosmological constant which renders inflation geodesically complete, while in the presence of a negative cosmological constant a cyclic universe emerges. We also provide an algorithm for tracking the super-Hubble perturbations during the bounce and show that the bouncing solutions are free from any perturbative instability

Higher-order stochastic differential equations and the positive Wigner function

Science.gov (United States)

Drummond, P. D.

2017-12-01

General higher-order stochastic processes that correspond to any diffusion-type tensor of higher than second order are obtained. The relationship of multivariate higher-order stochastic differential equations with tensor decomposition theory and tensor rank is explained. Techniques for generating the requisite complex higher-order noise are proved to exist either using polar coordinates and γ distributions, or from products of Gaussian variates. This method is shown to allow the calculation of the dynamics of the Wigner function, after it is extended to a complex phase space. The results are illustrated physically through dynamical calculations of the positive Wigner distribution for three-mode parametric downconversion, widely used in quantum optics. The approach eliminates paradoxes arising from truncation of the higher derivative terms in Wigner function time evolution. Anomalous results of negative populations and vacuum scattering found in truncated Wigner quantum simulations in quantum optics and Bose-Einstein condensate dynamics are shown not to occur with this type of stochastic theory.

Scalar brane backgrounds in higher order curvature gravity

International Nuclear Information System (INIS)

Charmousis, Christos; Davis, Stephen C.; Dufaux, Jean-Francois

2003-01-01

We investigate maximally symmetric brane world solutions with a scalar field. Five-dimensional bulk gravity is described by a general lagrangian which yields field equations containing no higher than second order derivatives. This includes the Gauss-Bonnet combination for the graviton. Stability and gravitational properties of such solutions are considered, and we particularly emphasise the modifications induced by the higher order terms. In particular it is shown that higher curvature corrections to Einstein theory can give rise to instabilities in brane world solutions. A method for analytically obtaining the general solution for such actions is outlined. Generically, the requirement of a finite volume element together with the absence of a naked singularity in the bulk imposes fine-tuning of the brane tension. A model with a moduli scalar field is analysed in detail and we address questions of instability and non-singular self-tuning solutions. In particular, we discuss a case with a normalisable zero mode but infinite volume element. (author)

Hawking radiation spectra for scalar fields by a higher-dimensional Schwarzschild-de Sitter black hole

Science.gov (United States)

Pappas, T.; Kanti, P.; Pappas, N.

2016-07-01

In this work, we study the propagation of scalar fields in the gravitational background of a higher-dimensional Schwarzschild-de Sitter black hole as well as on the projected-on-the-brane four-dimensional background. The scalar fields have also a nonminimal coupling to the corresponding, bulk or brane, scalar curvature. We perform a comprehensive study by deriving exact numerical results for the greybody factors, and study their profile in terms of particle and spacetime properties. We then proceed to derive the Hawking radiation spectra for a higher-dimensional Schwarzschild-de Sitter black hole, and we study both bulk and brane channels. We demonstrate that the nonminimal field coupling, which creates an effective mass term for the fields, suppresses the energy emission rates while the cosmological constant assumes a dual role. By computing the relative energy rates and the total emissivity ratio for bulk and brane emission, we demonstrate that the combined effect of a large number of extra dimensions and value of the field coupling gives to the bulk channel the clear domination in the bulk-brane energy balance.

Evaluating satellite-derived long-term historical precipitation datasets for drought monitoring in Chile

Science.gov (United States)

Zambrano, Francisco; Wardlow, Brian; Tadesse, Tsegaye; Lillo-Saavedra, Mario; Lagos, Octavio

2017-04-01

Precipitation is a key parameter for the study of climate change and variability and the detection and monitoring of natural disaster such as drought. Precipitation datasets that accurately capture the amount and spatial variability of rainfall is critical for drought monitoring and a wide range of other climate applications. This is challenging in many parts of the world, which often have a limited number of weather stations and/or historical data records. Satellite-derived precipitation products offer a viable alternative with several remotely sensed precipitation datasets now available with long historical data records (+30years), which include the Climate Hazards Group InfraRed Precipitation with Station (CHIRPS) and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR) datasets. This study presents a comparative analysis of three historical satellite-based precipitation datasets that include Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA) 3B43 version 7 (1998-2015), PERSIANN-CDR (1983-2015) and CHIRPS 2.0 (1981-2015) over Chile to assess their performance across the country and for the case of the two long-term products the applicability for agricultural drought were evaluated when used in the calculation of commonly used drought indicator as the Standardized Precipitation Index (SPI). In this analysis, 278 weather stations of in situ rainfall measurements across Chile were initially compared to the satellite data. The study area (Chile) was divided into five latitudinal zones: North, North-Central, Central, South-Central and South to determine if there were a regional difference among these satellite products, and nine statistics were used to evaluate their performance to estimate the amount and spatial distribution of historical rainfall across Chile. Hierarchical cluster analysis, k-means and singular value decomposition were used to analyze

Synthesis of octahedral like Cu-BTC derivatives derived from MOF calcined under different atmosphere for application in CO oxidation

Science.gov (United States)

Yang, Yiqiong; Dong, Han; Wang, Yin; He, Chi; Wang, Yuxin; Zhang, Xiaodong

2018-02-01

A series of octahedral structure Cu-BTC derivatives were successfully achieved through direct calcination of copper based metal organic framework Cu-BTC under different atmosphere (CO reaction gas, oxidizing gas O2, reducing gas H2, inert gas Ar). The Cu-BTC derivatives were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), laser Raman spectroscopy (LRS), N2 adsorption-desorption isotherm, element analysis, H2-temperature program reduction (H2-TPR) and X-ray photoelectron spectroscopic (XPS). It is found that Cu-BTC derivative derived from MOF calcined under reaction gas/O2 (Cu-BTC-CO/Cu-BTC-O) only retain Cu2O and CuO species. In addition, a weak Cu-BTC structure and Cu particles were observed on Cu-BTC derivative derived from MOF calcined under H2 (Cu-BTC-H). Obviously differently, Cu-BTC derivative derived from MOF calcined under Ar (Cu-BTC-Ar) still retains good MOF structure. The catalytic performance for CO oxidation over Cu-BTC derivatives was studied. It was found that Cu-BTC-CO showed a smaller specific surface area (8.0 m2/g), but presented an excellent catalytic performance, long-term stability and cycling stability with a complete CO conversion temperature (T100) of 140 °C, which was ascribed to the higher Cu2O/CuO ratio, good low temperature reduction behavior and a high quantity of surface active oxygen species.

On four-derivative terms in IIB Calabi-Yau orientifold reductions

Energy Technology Data Exchange (ETDEWEB)

Weissenbacher, Matthias [Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo,Kashiwa-no-ha 5-1-5, 277-8583 (Japan)

2017-04-11

We perform a Kaluza-Klein reduction of IIB supergravity including purely gravitational α{sup ′3}-corrections on a Calabi-Yau threefold, and perform the orientifold projection accounting for the presence of O3/O7-planes. We consider infinitesimal Kähler deformations of the Calabi-Yau background and derive the complete set of four-derivative couplings quadratic in these fluctuations coupled to gravity. In particular, we find four-derivative couplings of the Kähler moduli fields in the four-dimensional effective supergravity theory, which are referred to as friction couplings in the context of inflation.

Higher Curvature Gravity from Entanglement in Conformal Field Theories

Science.gov (United States)

Haehl, Felix M.; Hijano, Eliot; Parrikar, Onkar; Rabideau, Charles

2018-05-01

By generalizing different recent works to the context of higher curvature gravity, we provide a unifying framework for three related results: (i) If an asymptotically anti-de Sitter (AdS) spacetime computes the entanglement entropies of ball-shaped regions in a conformal field theory using a generalized Ryu-Takayanagi formula up to second order in state deformations around the vacuum, then the spacetime satisfies the correct gravitational equations of motion up to second order around the AdS background. (ii) The holographic dual of entanglement entropy in higher curvature theories of gravity is given by the Wald entropy plus a particular correction term involving extrinsic curvatures. (iii) Conformal field theory relative entropy is dual to gravitational canonical energy (also in higher curvature theories of gravity). Especially for the second point, our novel derivation of this previously known statement does not involve the Euclidean replica trick.

Practical implementation of a higher order transverse leakage approximation

International Nuclear Information System (INIS)

Prinsloo, Rian H.; Tomašević

2011-01-01

Transverse integrated nodal diffusion methods currently represent the standard in full core neutronic simulation. The primary shortcoming in this approach, be it via the Analytic Nodal Method or Nodal Expansion Method, is the utilization of the quadratic transverse leakage approximation. This approach, although proven to work well for typical LWR problems, is not consistent with the formulation of nodal methods and can cause accuracy and convergence problems. In this work an improved, consistent quadratic leakage approximation is formulated, which derives from the class of higher order nodal methods developed some years ago. In this new approach, only information relevant to describing the transverse leak- age terms in the zero-order nodal equations are obtained from the higher order formalism. The method yields accuracy comparable to full higher order methods, but does not suffer from the same computational burden which these methods typically incur. (author)

Existence and Uniqueness of Solutions for Coupled Systems of Higher-Order Nonlinear Fractional Differential Equations

Directory of Open Access Journals (Sweden)

Ahmad Bashir

2010-01-01

Full Text Available We study an initial value problem for a coupled Caputo type nonlinear fractional differential system of higher order. As a first problem, the nonhomogeneous terms in the coupled fractional differential system depend on the fractional derivatives of lower orders only. Then the nonhomogeneous terms in the fractional differential system are allowed to depend on the unknown functions together with the fractional derivative of lower orders. Our method of analysis is based on the reduction of the given system to an equivalent system of integral equations. Applying the nonlinear alternative of Leray-Schauder, we prove the existence of solutions of the fractional differential system. The uniqueness of solutions of the fractional differential system is established by using the Banach contraction principle. An illustrative example is also presented.

Electrochemical Study of Hydrocarbon-Derived Electrolytes for Supercapacitors

Science.gov (United States)

Noorden, Zulkarnain A.; Matsumoto, Satoshi

2013-10-01

In this paper, we evaluate the essential electrochemical properties - capacitive and resistive behaviors - of hydrocarbon-derived electrolytes for supercapacitor application using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electrolytes were systematically prepared from three hydrocarbon-derived compounds, which have different molecular structures and functional groups, by treatment with high-concentration sulfuric acid (H2SO4) at room temperature. Two-electrode cells were assembled by sandwiching an electrolyte-containing glass wool separator with two active electrodes of activated carbon sheets. The dc electrical properties of the tested cells in terms of their capacitive behavior were investigated by CV, and in order to observe the frequency characteristics of the constructed cells, EIS was carried out. Compared with the tested cell with only high-concentration H2SO4 as the electrolyte, the cell with the derived electrolytes exhibit a capacitance as high as 135 F/g with an improved overall internal resistance of 2.5 Ω. Through the use of a simple preparation method and low-cost precursors, hydrocarbon-derived electrolytes could potentially find large-scale and higher-rating supercapacitor applications.

Improved derivation of the modified BGK collision term and applications to the Hall effect and cold plasma dispersion relation

International Nuclear Information System (INIS)

Nagata, M.

1983-01-01

A derived addition to the BGK collision term,is improved and expressed in simple form. The collision frequency for scattering depends anisotropically on the velocity vector. The improved macroscopic equation of momentum flow is applied to the Hall effect, the cold plasma dispersion relation and the cyclotron resonance. The Hall coefficient which is constant in the case of the BGK collision term now depends on the magnetic field. It is also shown that, compared with the almost symmetric classical curves of cyclotron resonance, the new curves are considerably asymmetric and their half-widths are about 3/2 times the classical ones. (autho)

Fractional Regularization Term for Variational Image Registration

Directory of Open Access Journals (Sweden)

Rafael Verdú-Monedero

2009-01-01

Full Text Available Image registration is a widely used task of image analysis with applications in many fields. Its classical formulation and current improvements are given in the spatial domain. In this paper a regularization term based on fractional order derivatives is formulated. This term is defined and implemented in the frequency domain by translating the energy functional into the frequency domain and obtaining the Euler-Lagrange equations which minimize it. The new regularization term leads to a simple formulation and design, being applicable to higher dimensions by using the corresponding multidimensional Fourier transform. The proposed regularization term allows for a real gradual transition from a diffusion registration to a curvature registration which is best suited to some applications and it is not possible in the spatial domain. Results with 3D actual images show the validity of this approach.

Energy derivatives, experiences in derivative trading from the natural gas industry : back to basics

International Nuclear Information System (INIS)

Dittmer, G.; Coyle, T.

1998-01-01

Some basic facts regarding derivatives in the electric power industry were discussed based on experiences in the natural gas industry. Derivatives were described as financial instruments that have no value of their own but derive their value from other assets, such as commodities. Futures and Options are the two forms of derivatives. Electricity as a commodity was characterized, and a historical parallel was drawn between deregulation in the natural gas and electric power industry. Short term and long term factors impacting the market and market dynamics impacting derivatives were identified. The latter include: (1) volatility, (2) liquidity, (3) correlations, and (4) price discovery. In contrast to the natural gas market, the electricity market is considered as lacking liquidity and in need of moving farther along the maturity timeline. The question of natural gas/ electricity convergence was also addressed refs., tabs., figs

Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs.

Science.gov (United States)

Huang, Xiaobing; Li, Chenglong; Zhu, Biao; Wang, Hailian; Luo, Xiangwei; Wei, Lingling

2016-05-01

In order to closely mimic a multi-cell state in hematopoietic stem/progenitor cells (HSC/HPCs) vascular niche, we co-cultured human bone marrow mesenchymal stem cells (hBMSCs) and human umbilical vein endothelial cells (HUVECs) without any cytokines as feeder cells and applied bio-derived bone from human femoral metaphyseal portion as scaffold to develop a new HSC/HPCs three-dimensional culture system (named 3D-Mix cultures). Scanning electron and fluorescent microscopy showed excellent biocompatibility of bio-derived bone to hBMSCs and HUVECs in vitro. Flow cytometry analysis and quantitative real-time polymerase chain reaction (qPCR) assay of p21 expression demonstrated that 3D-Mix could promote self-renewal and ex vivo expansion of HSCs/HPCs significantly higher than 3D-hMSC and 3D-HUVEC. Long-term culture initiating cell (LTC-IC) confirmed that 3D-Mix had the most powerful activity of maintaining multipotent differentiation of primitive cell subpopulation in HSCs. The nonobese diabetic/severe combined immunodeficiency (NOD/SCID) repopulating cell (SRC) assay demonstrated that 3D-Mix promoted the expansion of long-term primitive transplantable HSCs. qPCR of alkaline phosphatase (ALP) and osteocalcin (OC) demonstrated that HUVECs enhanced the early osteogenic differentiation of BMSCs. Western blot and qPCR revealed that HUVECs activated Wnt/β-catenin signaling in hBMSCs inducing Notch signal activation in HSCs. Our study indicated that interaction between hMSCs and HUVECs may have a critical role in to influent on HSCs/HPCs fate in vitro. These results demonstrated that the 3D-Mix have the ability to support the maintenance and proliferation of HSCs/HPCs in vitro. © 2016 Wiley Periodicals, Inc.

Propagation of high power electromagnetic beam in relativistic magnetoplasma: Higher order paraxial ray theory

Science.gov (United States)

Gill, Tarsem Singh; Kaur, Ravinder; Mahajan, Ranju

2010-09-01

This paper presents an analysis of self-consistent, steady-state, theoretical model, which explains the ring formation in a Gaussian electromagnetic beam propagating in a magnetoplasma, characterized by relativistic nonlinearity. Higher order terms (up to r4) in the expansion of the dielectric function and the eikonal have been taken into account. The condition for the formation of a dark and bright ring derived earlier by Misra and Mishra [J. Plasma Phys. 75, 769 (2009)] has been used to study focusing/defocusing of the beam. It is seen that inclusion of higher order terms does significantly affect the dependence of the beam width on the distance of propagation. Further, the effect of the magnetic field and the nature of nonlinearity on the ring formation and self-focusing of the beam have been explored.

Propagation of high power electromagnetic beam in relativistic magnetoplasma: Higher order paraxial ray theory

International Nuclear Information System (INIS)

Gill, Tarsem Singh; Kaur, Ravinder; Mahajan, Ranju

2010-01-01

This paper presents an analysis of self-consistent, steady-state, theoretical model, which explains the ring formation in a Gaussian electromagnetic beam propagating in a magnetoplasma, characterized by relativistic nonlinearity. Higher order terms (up to r 4 ) in the expansion of the dielectric function and the eikonal have been taken into account. The condition for the formation of a dark and bright ring derived earlier by Misra and Mishra [J. Plasma Phys. 75, 769 (2009)] has been used to study focusing/defocusing of the beam. It is seen that inclusion of higher order terms does significantly affect the dependence of the beam width on the distance of propagation. Further, the effect of the magnetic field and the nature of nonlinearity on the ring formation and self-focusing of the beam have been explored.

Assessment of the Contribution of Regional Higher Education Systems to the Socio-Economic Development of the Russian Regions

Science.gov (United States)

Leshukov, O. V.; Yevseyeva, D. G.; Gromov, A. D.; Platonova, D. P.

2017-01-01

This article analyzes how Russia's networks of higher education institutions contribute to their host regions in terms of the following three major facets: the economic development; the human capital development; and the innovative development. To ensure the analytical framework used derives relevant and representative findings given the nature of…

RxTerms

Data.gov (United States)

U.S. Department of Health & Human Services — RxTerms is a drug interface terminology derived from RxNorm for prescription writing or medication history recording (e.g. in e-prescribing systems, PHRs). RxTerms...

Ultrashort optical solitons in the cubic-quintic complex Ginzburg-Landau equation with higher-order terms

International Nuclear Information System (INIS)

Fewo, Serge I.; Kofane, Timoleon C.; Ngabireng, Claude M.

2008-01-01

With the help of the Maxwell equations, a basic equation modeling the propagation of ultrashort optical solitons in optical fiber is derived, namely the higher-order complex Ginzburg-Landau equation (HCGLE). Considering this one-dimensional HCGLE, we obtain a set of differential equations characterizing the variation of the pulse parameters called collective variables (CVs), of a pulse propagating in dispersion-managed (DM) fiber optic-links. Equations obtained are investigated numerically in order to observe the behaviour of pulse parameters along the optical fiber. A fully numerical simulation of the one-dimensional HCGLE finally tests the results of the CV theory. A good agreement between both methods is observed. Among various behaviours, chaotic pulses, attenuate pulses and stable pulses can be obtained under certain parameter values. (author)

Hyaluronan preserves the proliferation and differentiation potentials of long-term cultured murine adipose-derived stromal cells

International Nuclear Information System (INIS)

Chen, P.-Y.; Huang, Lynn L.H.; Hsieh, H.-J.

2007-01-01

For long-term culture, murine adipose-derived stromal cells (mADSCs) at latter passages demonstrated a marked decline in proliferative activity, exhibited senescent morphology and reduced differentiation potentials, particularly osteogenesis. To extend the lifespan of mADSCs, two culture conditions containing hyaluronan (HA) was compared in our study, one as a culture medium supplement (SHA), and the other where HA was pre-coated on culture surface (CHA). mADSCs cultivated with SHA exhibited a prolonged lifespan, reduced cellular senescence, and enhanced osteogenic potential compared to regular culture condition (control). Upon CHA treatment, mADSCs tended to form cell aggregates with gradual growth profiles, while their differentiation activities remained similar to SHA groups. After transferring mADSCs from CHA to control surface, they were shown to have an extended lifespan and an increase of osteogenic potential. Our results suggested that HA can be useful for preserving the proliferation and differentiation potentials of long-term cultured mADSCs

Credit derivatives in emerging markets

OpenAIRE

Romain Rancière

2002-01-01

Credit Derivatives are securities that offer protection against credit or default risk of bonds or loans. The credit derivatives emerging market has grown rapidly and credit derivatives are widely used. This paper describes the emerging credit derivatives market structure. The current market activity is analyzed through elementary pricing dynamics and the study of the term structure of default risk. Focusing on the performance of credit derivatives in stress situation, including legal and mar...

Integrating across Episodes: Investigating the Long-term Accessibility of Self-derived Knowledge in 4-Year-Old Children

Science.gov (United States)

Varga, Nicole L.; Stewart, Rebekah A.; Bauer, Patricia J.

2016-01-01

Semantic memory, defined as our store of knowledge about the world, provides representational support for all of our higher order cognitive functions. As such, it is crucial that the contents of semantic memory remain accessible over time. Although memory for knowledge learned through direct observation has been previously investigated, we know very little about the retention of knowledge derived through integration of information acquired across separate learning episodes. The present research investigated cross-episode integration in 4-year-old children. Participants were presented with novel facts via distinct story episodes and tested for knowledge extension through cross-episode integration, as well as for retention of the information over a 1-week delay. In Experiment 1, children retained the self-derived knowledge over the delay, though performance was primarily evidenced in a forced-choice format. In Experiment 2, we sought to facilitate the accessibility and robustness of self-derived knowledge by providing a verbal reminder after the delay. The accessibility of self-derived knowledge increased, irrespective of whether participants successfully demonstrated knowledge of the integration facts during the first visit. The results suggest knowledge extended through integration remains accessible after delays, even in a population in which this learning process is less robust. The findings also demonstrate the facilitative effect of reminders on the accessibility and further extension of knowledge over extended time periods. PMID:26774259

Dental pulp-derived stromal cells exhibit a higher osteogenic potency than bone marrow-derived stromal cells in vitro and in a porcine critical-size bone defect model

Directory of Open Access Journals (Sweden)

Jensen Jonas

2016-01-01

Full Text Available Introduction: The osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs was compared with that of dental pulp-derived stromal cells (DPSCs in vitro and in a pig calvaria critical-size bone defect model. Methods: BMSCs and DPSCs were extracted from the tibia bone marrow and the molar teeth of each pig, respectively. BMSCs and DPSCs were cultured in monolayer and on a three-dimensional (3D polycaprolactone (PCL – hyaluronic acid – tricalcium phosphate (HT-PCL scaffold. Population doubling (PD, alkaline phosphatase (ALP activity, and calcium deposition were measured in monolayer. In the 3D culture ALP activity, DNA content, and calcium deposition were evaluated. Six non-penetrating critical-size defects were made in each calvarium of 14 pigs. Three paired sub-studies were conducted: (1 empty defects vs. HT-PCL scaffolds; (2 PCL scaffolds vs. HT-PCL scaffolds; and (3 autologous BMSCs on HT-PCL scaffolds vs. autologous DPSCs on HT-PCL scaffolds. The observation time was five weeks. Bone volume fractions (BV/TV were assessed with micro-computed tomography (μCT and histomorphometry. Results and discussion: The results from the in vitro study revealed a higher ALP activity and calcium deposition of the DPSC cultures compared with BMSC cultures. Significantly more bone was present in the HT-PCL group than in both the pure PCL scaffold group and the empty defect group in vivo. DPSCs generated more bone than BMSCs when seeded on HT-PCL. In conclusion, DPSCs exhibited a higher osteogenic potential compared with BMSCs both in vitro and in vivo, making it a potential cell source for future bone tissue engineering.

Higher curvature supergravity and cosmology

Energy Technology Data Exchange (ETDEWEB)

Ferrara, Sergio [Th-Ph Department, CERN, Geneva (Switzerland); U.C.L.A., Los Angeles, CA (United States); INFN - LNF, Frascati (Italy); Sagnotti, Augusto [Scuola Normale Superiore, Pisa (Italy); INFN, Pisa (Italy)

2016-04-15

In this contribution we describe dual higher-derivative formulations of some cosmological models based on supergravity. Work in this direction started with the R + R{sup 2} Starobinsky model, whose supersymmetric extension was derived in the late 80's and was recently revived in view of new CMB data. Models dual to higher-derivative theories are subject to more restrictions than their bosonic counterparts or standard supergravity. The three sections are devoted to a brief description of R + R{sup 2} supergravity, to a scale invariant R{sup 2} supergravity and to theories with a nilpotent curvature, whose duals describe non-linear realizations (in the form of a Volkov-Akulov constrained superfield) coupled to supergravity. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

International Experience in Reforming the System of Higher Education Governance in terms of Increasing the University Autonomy

Directory of Open Access Journals (Sweden)

Chmutova Iryna M.

2017-12-01

Full Text Available The aim of the article is to summarize the international experience of reforming the system of higher education governance and develop directions that will contribute to increasing the effectiveness of the Ukrainian model for governance of higher education and ensuring its autonomy. There identified common elements and trends in European higher education reforms: greater autonomy for higher education institutions with less direct administrative intervention; greater emphasis on private rather than public funding; emphasis on the quality and effectiveness of education. The tools for implementing reforms in the European higher education system are identified: the New Public Management (NPM model, governance through networks, and new forms of governance. The changes in the university autonomy of European countries for the period of 2010-2016 are summarized. The content of the reforms in terms of increasing the autonomy of HEIs in the countries of Asia is disclosed. Possible vectors for reforming the system of higher education governance in Ukraine are identified: introduction of a model for funding HEIs on the basis of combining a one-time full budgeting and financing by results; assigning universities ownership of their buildings and their sale in the market; strengthening the decentralization of government control of higher education; development of legislative bases for the self-sufficiency of HEIs; inclusion of external stakeholders in decision-making governing bodies of HEIs; maximum involvement of students in decision-making.

Higher-order (non-)modularity

DEFF Research Database (Denmark)

Appel, Claus; van Oostrom, Vincent; Simonsen, Jakob Grue

2010-01-01

We show that, contrary to the situation in first-order term rewriting, almost none of the usual properties of rewriting are modular for higher-order rewriting, irrespective of the higher-order rewriting format. We show that for the particular format of simply typed applicative term rewriting...... systems modularity of confluence, normalization, and termination can be recovered by imposing suitable linearity constraints....

Derivative self-interactions for a massive vector field

Energy Technology Data Exchange (ETDEWEB)

Beltrán Jiménez, Jose, E-mail: jose.beltran@cpt.univ-mrs.fr [CPT, Aix Marseille Université, UMR 7332, 13288 Marseille (France); Heisenberg, Lavinia, E-mail: lavinia.heisenberg@eth-its.ethz.ch [Institute for Theoretical Studies, ETH Zurich, Clausiusstrasse 47, 8092 Zurich (Switzerland)

2016-06-10

In this work we revisit the construction of theories for a massive vector field with derivative self-interactions such that only the 3 desired polarizations corresponding to a Proca field propagate. We start from the decoupling limit by constructing healthy interactions containing second derivatives of the Stueckelberg field with itself and also with the transverse modes. The resulting interactions can then be straightforwardly generalized beyond the decoupling limit. We then proceed to a systematic construction of the interactions by using the Levi–Civita tensors. Both approaches lead to a finite family of allowed derivative self-interactions for the Proca field. This construction allows us to show that some higher order terms recently introduced as new interactions trivialize in 4 dimensions by virtue of the Cayley–Hamilton theorem. Moreover, we discuss how the resulting derivative interactions can be written in a compact determinantal form, which can also be regarded as a generalization of the Born-Infeld lagrangian for electromagnetism. Finally, we generalize our results for a curved background and give the necessary non-minimal couplings guaranteeing that no additional polarizations propagate even in the presence of gravity.

Generalized Uncertainty Principle and Black Hole Entropy of Higher-Dimensional de Sitter Spacetime

International Nuclear Information System (INIS)

Zhao Haixia; Hu Shuangqi; Zhao Ren; Li Huaifan

2007-01-01

Recently, there has been much attention devoted to resolving the quantum corrections to the Bekenstein-Hawking black hole entropy. In particular, many researchers have expressed a vested interest in the coefficient of the logarithmic term of the black hole entropy correction term. In this paper, we calculate the correction value of the black hole entropy by utilizing the generalized uncertainty principle and obtain the correction term caused by the generalized uncertainty principle. Because in our calculation we think that the Bekenstein-Hawking area theorem is still valid after considering the generalized uncertainty principle, we derive that the coefficient of the logarithmic term of the black hole entropy correction term is positive. This result is different from the known result at present. Our method is valid not only for four-dimensional spacetimes but also for higher-dimensional spacetimes. In the whole process, the physics idea is clear and calculation is simple. It offers a new way for studying the entropy correction of the complicated spacetime.

Establishment and long-term culture of the cell lines derived from gonad tissues of Siberian sturgeon (Acipenser baerii

Directory of Open Access Journals (Sweden)

Jun Hyung Ryu

2016-06-01

Full Text Available Abstract To culture germline stem cells in vitro, establishment of the cell lines that can be used as the feeder cells is a prerequisite. In this study, we tried to establish gonad-derived cell lines in Siberian sturgeon (Acipenser baerii. Five 1-year-old A. baerii were used as a donor of gonad tissues, and gonad-dissociated cells were cultured in vitro. Subsequently, determination of growth conditions, long-term culture, characterization, and cryopreservation of the cell lines were also conducted. Five gonad-derived cell lines were stably established and cultured continuously over at least the 73th passage and 402 culture days under the media containing 20 % fetal bovine serum at 28 °C. All cell lines consisted of two main cell types based on morphology even if the ratio of the two cell types was different depending on cell lines. Despite long-term culture, all cell lines maintained diploid DNA contents and expression of several genes that are known to express in the A. baerii gonad. After freezing and thawing of the cell lines, post-thaw cell viabilities between 57.6 and 92.9 % depending on cell lines were indentified, suggesting that stable cryopreservation is possible. The results and the cell lines established in this study will contribute to the development of an in vitro system for A. baerii germline stem cell culture.

Multi-Hamiltonian formulations and stability of higher-derivative extensions of 3d Chern-Simons

Energy Technology Data Exchange (ETDEWEB)

Abakumova, V.A.; Kaparulin, D.S.; Lyakhovich, S.L. [Tomsk State University, Physics Faculty, Tomsk (Russian Federation)

2018-02-15

Most general third-order 3d linear gauge vector field theory is considered. The field equations involve, besides the mass, two dimensionless constant parameters. The theory admits two-parameter series of conserved tensors with the canonical energy-momentum being a particular representative of the series. For a certain range of the model parameters, the series of conserved tensors include bounded quantities. This makes the dynamics classically stable, though the canonical energy is unbounded in all the instances. The free third-order equations are shown to admit constrained multi-Hamiltonian form with the 00-components of conserved tensors playing the roles of corresponding Hamiltonians. The series of Hamiltonians includes the canonical Ostrogradski's one, which is unbounded. The Hamiltonian formulations with different Hamiltonians are not connected by canonical transformations. This means, the theory admits inequivalent quantizations at the free level. Covariant interactions are included with spinor fields such that the higher-derivative dynamics remains stable at interacting level if the bounded conserved quantity exists in the free theory. In the first-order formalism, the interacting theory remains Hamiltonian and therefore it admits quantization, though the vertices are not necessarily Lagrangian in the third-order field equations. (orig.)

Derivation of the density functional theory from the cluster expansion.

Science.gov (United States)

Hsu, J Y

2003-09-26

The density functional theory is derived from a cluster expansion by truncating the higher-order correlations in one and only one term in the kinetic energy. The formulation allows self-consistent calculation of the exchange correlation effect without imposing additional assumptions to generalize the local density approximation. The pair correlation is described as a two-body collision of bound-state electrons, and modifies the electron- electron interaction energy as well as the kinetic energy. The theory admits excited states, and has no self-interaction energy.

Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

Energy Technology Data Exchange (ETDEWEB)

Tomar, Geetanjali B.; Srivastava, Rupesh K.; Gupta, Navita; Barhanpurkar, Amruta P.; Pote, Satish T. [National Center for Cell Science, University of Pune Campus, Pune 411 007 (India); Jhaveri, Hiral M. [Department of Periodontics and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Pune (India); Mishra, Gyan C. [National Center for Cell Science, University of Pune Campus, Pune 411 007 (India); Wani, Mohan R., E-mail: mohanwani@nccs.res.in [National Center for Cell Science, University of Pune Campus, Pune 411 007 (India)

2010-03-12

Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation into multiple cell lineages. Presently, bone marrow is considered as a prime source of MSCs; however, there are some drawbacks and limitations in use of these MSCs for cell therapy. In this study, we demonstrate that human gingival tissue-derived MSCs have several advantages over bone marrow-derived MSCs. Gingival MSCs are easy to isolate, homogenous and proliferate faster than bone marrow MSCs without any growth factor. Importantly, gingival MSCs display stable morphology and do not loose MSC characteristic at higher passages. In addition, gingival MSCs maintain normal karyotype and telomerase activity in long-term cultures, and are not tumorigenic. Thus, we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.

Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

International Nuclear Information System (INIS)

Tomar, Geetanjali B.; Srivastava, Rupesh K.; Gupta, Navita; Barhanpurkar, Amruta P.; Pote, Satish T.; Jhaveri, Hiral M.; Mishra, Gyan C.; Wani, Mohan R.

2010-01-01

Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation into multiple cell lineages. Presently, bone marrow is considered as a prime source of MSCs; however, there are some drawbacks and limitations in use of these MSCs for cell therapy. In this study, we demonstrate that human gingival tissue-derived MSCs have several advantages over bone marrow-derived MSCs. Gingival MSCs are easy to isolate, homogenous and proliferate faster than bone marrow MSCs without any growth factor. Importantly, gingival MSCs display stable morphology and do not loose MSC characteristic at higher passages. In addition, gingival MSCs maintain normal karyotype and telomerase activity in long-term cultures, and are not tumorigenic. Thus, we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.

The cytoskeleton of Drosophila-derived Schneider line-1 and Kc23 cells undergoes significant changes during long-term culture

Science.gov (United States)

Schatten, H.; Hedrick, J.; Chakrabarti, A.

1998-01-01

Insect cell cultures derived from Drosophila melanogaster are increasingly being used as an alternative system to mammalian cell cultures, as they are amenable to genetic manipulation. Although Drosophila cells are an excellent tool for the study of genes and expression of proteins, culture conditions have to be considered in the interpretation of biochemical results. Our studies indicate that significant differences occur in cytoskeletal structure during the long-term culture of the Drosophila-derived cell lines Schneider Line-1 (S1) and Kc23. Scanning, transmission-electron, and immunofluorescence microscopy studies reveal that microfilaments, microtubules, and centrosomes become increasingly different during the culture of these cells from 24 h to 7-14 days. Significant cytoskeletal changes are observed at the cell surface where actin polymerizes into microfilaments, during the elongation of long microvilli. Additionally, long protrusions develop from the cell surface; these protrusions are microtubule-based and establish contact with neighboring cells. In contrast, the microtubule network in the interior of the cells becomes disrupted after four days of culture, resulting in altered transport of mitochondria. Microtubules and centrosomes are also affected in a small percent of cells during cell division, indicating an instability of centrosomes. Thus, the cytoskeletal network of microfilaments, microtubules, and centrosomes is affected in Drosophila cells during long-term culture. This implies that gene regulation and post-translational modifications are probably different under different culture conditions.

Taxation of Derivatives

DEFF Research Database (Denmark)

Dyppel, Katja Joo

2013-01-01

The main objective for this thesis is to analyse and systematise the Danish legislation on taxation of derivatives. According to financial terminology, a derivative is a financial instrument. Its value is derived from changes in the value of one or more underlying assets.The most common derivatives...... in the Danish tax legislation. However, contracts known as forwards (terminskontrakter) and options (aftaler om køberetter og salgsretter) are generally included in the term financials contracts covered by the Danish Act on Taxation of Gains and Losses on Claims and Debt. The main part of the analysis deals...... with the scope of sections 29-33 of the Danish Act on Taxation of Gains and Losses on Claims and Debt and the tax consequences for the covered financial contracts. In the analysis of taxation of derivatives, the fundamental issues of qualification and tax treatment of the instruments are dealt with....

Utilization of Plutonium and Higher Actinides in the HTGR as Possibility to Maintain Long-Term Operation on One Fuel Loading

International Nuclear Information System (INIS)

Tsvetkova, Galina V.; Peddicord, Kenneth L.

2002-01-01

Promising existing nuclear reactor concepts together with new ideas are being discussed worldwide. Many new studies are underway in order to identify prototypes that will be analyzed and developed further as systems for Generation IV. The focus is on designs demonstrating full inherent safety, competitive economics and proliferation resistance. The work discussed here is centered on a modularized small-size High Temperature Gas-cooled Reactor (HTGR) concept. This paper discusses the possibility of maintaining long-term operation on one fuel loading through utilization of plutonium and higher actinides in the small-size pebble-bed reactor (PBR). Acknowledging the well-known flexibility of the PBR design with respect to fuel composition, the principal limitations of the long-term burning of plutonium and higher actinides are considered. The technological challenges and further research are outlined. The results allow the identification of physical features of the PBR that significantly influence flexibility of the design and its applications. (authors)

Higher-order force moments of active particles

Science.gov (United States)

Nasouri, Babak; Elfring, Gwynn J.

2018-04-01

Active particles moving through fluids generate disturbance flows due to their activity. For simplicity, the induced flow field is often modeled by the leading terms in a far-field approximation of the Stokes equations, whose coefficients are the force, torque, and stresslet (zeroth- and first-order force moments) of the active particle. This level of approximation is quite useful, but may also fail to predict more complex behaviors that are observed experimentally. In this study, to provide a better approximation, we evaluate the contribution of the second-order force moments to the flow field and, by reciprocal theorem, present explicit formulas for the stresslet dipole, rotlet dipole, and potential dipole for an arbitrarily shaped active particle. As examples of this method, we derive modified Faxén laws for active spherical particles and resolve higher-order moments for active rod-like particles.

Ward Identities of W_{\\infty} Symmetry and Higher Genus Amplitudes in 2D String Theory

OpenAIRE

Hamada, Ken-ji

1995-01-01

The Ward identities of the $W_{\\infty}$ symmetry in two dimensional string theory in the tachyon background are studied in the continuum approach. We consider amplitudes different from 2D string ones by the external leg factor and derive the recursion relations among them. The recursion relations have non-linear terms which give relations among the amplitudes defined on different genus. The solutions agree with the matrix model results even in higher genus. We also discuss differences of role...

12 CFR 223.33 - What rules apply to derivative transactions?

Science.gov (United States)

2010-01-01

... Requirements Under Section 23A § 223.33 What rules apply to derivative transactions? (a) Market terms... with affiliates comply with the market terms requirement of § 223.51. (c) Credit derivatives. A credit... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What rules apply to derivative transactions...

Positive solutions of fractional differential equations with derivative terms

Directory of Open Access Journals (Sweden)

Cuiping Cheng

2012-11-01

Full Text Available In this article, we are concerned with the existence of positive solutions for nonlinear fractional differential equation whose nonlinearity contains the first-order derivative, $$displaylines{ D_{0^+}^{alpha}u(t+f(t,u(t,u'(t=0,quad tin (0,1,; n-14 $ $(ninmathbb{N}$, $D_{0^+}^{alpha}$ is the standard Riemann-Liouville fractional derivative of order $alpha$ and $f(t,u,u':[0,1] imes [0,inftyimes(-infty,+infty o [0,infty$ satisfies the Caratheodory type condition. Sufficient conditions are obtained for the existence of at least one or two positive solutions by using the nonlinear alternative of the Leray-Schauder type and Krasnosel'skii's fixed point theorem. In addition, several other sufficient conditions are established for the existence of at least triple, n or 2n-1 positive solutions. Two examples are given to illustrate our theoretical results.

Measurement of global and local resonance terms

CERN Document Server

Tomás, R; Calaga, R; Fischer, W; Franchi, A; Rumolo, Giovanni

2005-01-01

Recently, resonance driving terms were successfully measured in the CERN SPS and the BNL RHIC from the Fourier spectrum of beam position monitor (BPM) data. Based on these measurements a new analysis has been derived to extract truly local observables from BPM data. These local observables are called local resonance terms since they share some similarities with the global resonance terms. In this paper we derive these local terms analytically and present experimental measurements of sextupolar global and local resonance terms in RHIC. Nondestructive measurements of these terms using ac dipoles are also presented.

Performance of small-scale aero-derivative industrial gas turbines derived from helicopter engines

Directory of Open Access Journals (Sweden)

Barinyima Nkoi

2013-12-01

Full Text Available This paper considers comparative assessment of simple and advanced cycle small-scale aero-derivative industrial gas turbines derived from helicopter engines. More particularly, investigation was made of technical performance of the small-scale aero-derivative engine cycles based on existing and projected cycles for applications in industrial power generation, combined heat and power concept, rotating equipment driving, and/or allied processes. The investigation was done by carrying out preliminary design and performance simulation of a simple cycle (baseline two-spool small-scale aero-derivative turboshaft engine model, and some advanced counterpart aero-derivative configurations. The advanced configurations consist of recuperated and intercooled/recuperated engine cycles of same nominal power rating of 1.567 MW. The baseline model was derived from the conversion of an existing helicopter engine model. In doing so, design point and off-design point performances of the engine models were established. In comparing their performances, it was observed that to a large extent, the advanced engine cycles showed superior performance in terms of thermal efficiency, and specific fuel consumption. In numerical terms, thermal efficiencies of recuperated engine cycle, and intercooled/recuperated engine cycles, over the simple cycle at DP increased by 13.5%, and 14.5% respectively, whereas specific fuel consumption of these cycles over simple cycle at DP decreased by 12.5%, and 13% respectively. This research relied on open access public literature for data.

Exploring Higher Thinking.

Science.gov (United States)

Conover, Willis M.

1992-01-01

Maintains that the social studies reform movement includes a call for the de-emphasis of rote memory and more attention to the development of higher-order thinking skills. Discusses the "thinking tasks" concept derived from the work of Hilda Taba and asserts that the tasks can be used with almost any social studies topic. (CFR)

Relative quality of internet-derived gastrointestinal cancer information.

Science.gov (United States)

Chan, David S Y; Willicombe, Anita; Reid, Thomas D; Beaton, Ceri; Arnold, David; Ward, James; Davies, I Llion; Lewis, Wyn G

2012-12-01

Internet-derived health care information is increasingly accessed by patients, yet its quality and accuracy is variable and unregulated. The aim of this study was to assess the information available regarding common gastrointestinal cancers via three internet search engines (Google, Yahoo and Bing). The top 30 websites for each of the terms: oesophageal, gastric, pancreatic, colon and rectal cancer were evaluated (University of Michigan Consumer Health Website Checklist) and scored [-80 (poor) to 90 (excellent)]. The median score was 53 (-7 to 81) and was significantly higher for oesophageal (61) and pancreatic (65) cancer websites, compared with gastric (49), colon (48) and rectal cancer (50) (p = 0.014). Median scores related to charitable organisations were significantly better than academic, commercial, news agency, care provider, layperson and medical information websites collectively (79 vs. 42, p < 0.0001). Overall quality of internet-derived gastrointestinal cancer information remains poor and patients and clinicians should be aware.

Chorionic villi derived mesenchymal like stem cells and expression of embryonic stem cells markers during long-term culturing.

Science.gov (United States)

Katsiani, E; Garas, A; Skentou, C; Tsezou, A; Messini, C I; Dafopoulos, K; Daponte, A; Messinis, I E

2016-09-01

Mesenchymal stem cells (MSCs) can be obtained from a variety of human tissues. MSCs derived from placental chorionic villi of the first trimester are likely to resemble, biologically, embryonic stem cells (ESC), due to the earlier development stage of placenta. In the present study long-term cultures of MSC-like cells were assessed in order to evaluate MSCs multipotent characteristics and molecular features during the period of culture. CV-cells obtained from 10 samples of chorionic villus displayed typical fibroblastoid morphology, undergone 20 passages during a period of 120 days, maintaining a stable karyotype throughout long term expansion. The cells were positive, for CD90, CD73, CD105, CD29, CD44, HLA ABC antigens and negative for CD14, CD34, AC133, and HLA DR antigens as resulted from the flow cytometry analysis. CV-cells were differentiated in adipocytes, osteoblasts, chondrocytes and neuronal cells under specific culture conditions. The expression of the ESC-gene markers POU5F1 (Oct-4) and NANOG was observed at earliest stages (4-12 passages) and not at the late stages (14-20 passages) by RT-PCR analysis. ZFP42 and SOX2 expression were not detected. Moreover, CV-cells were found to express GATA4 but not NES (Nestin). Chorionic villi-derived cells possess multipotent properties, display high proliferation rate and self-renew capacity, share common surface antigens with adult MSCs and express certain embryonics stem cells gene markers. These characteristics highlight chorionic villi as an attractive source of MSCs for the needs of regenerative medicine.

Modular transformations of conformal blocks in WZW models on Riemann surfaces of higher genus

International Nuclear Information System (INIS)

Miao Li; Ming Yu.

1989-05-01

We derive the modular transformations for conformal blocks in Wess-Zumino-Witten models on Riemann surfaces of higher genus. The basic ingredient consists of using the Chern-Simons theory developed by Witten. We find that the modular transformations generated by Dehn twists are linear combinations of Wilson line operators, which can be expressed in terms of braiding matrices. It can also be shown that modular transformation matrices for g > 0 Riemann surfaces depend only on those for g ≤ 3. (author). 13 refs, 15 figs

HIGHER EDUCATIONAL INSTITUTION AS A SUBJECT OF ADAPTATION OF RURAL STUDENTS TO THE TERMS OF THE CITY

Directory of Open Access Journals (Sweden)

Alyona Aleksandrovna Antipova

2014-11-01

Full Text Available The article is devoted to the difficulties of adaptation of rural students to the various spheres of life of the modern city. These difficulties are considered as a field of activity of higher educational institution, acting as the subject of adaptation of students coming to study from rural areas to the terms of the city. The authors ' point of view on this issue is substantiated by the analysis of data of several sociological surveys conducted in various regions of theRussian Federation. Also the experience of assistance in adaptation of the Mordovia state University named after N. P. Ogarev of the city ofSaransk, which is the largest in the Republic of Mordovia University and which accommodates a large number of rural youth. The relevance and scientific novelty of research consists in allocation of areas of adaptation support of students from rural areas by the higher educational institution.

Hawking Radiation Spectra for Scalar Fields by a Higher-Dimensional Schwarzschild-de-Sitter Black Hole

OpenAIRE

Pappas, T.; Kanti, P.; Pappas, N.

2016-01-01

In this work, we study the propagation of scalar fields in the gravitational background of a higher-dimensional Schwarzschild-de-Sitter black hole as well as on the projected-on-the-brane 4-dimensional background. The scalar fields have also a non-minimal coupling to the corresponding, bulk or brane, scalar curvature. We perform a comprehensive study by deriving exact numerical results for the greybody factors, and study their profile in terms of particle and spacetime properties. We then pro...

Nitrogen Amendment Stimulated Decomposition of Maize Straw-Derived Biochar in a Sandy Loam Soil: A Short-Term Study.

Directory of Open Access Journals (Sweden)

Weiwei Lu

Full Text Available This study examined the effect of nitrogen (N on biochar stability in relation to soil microbial community as well as biochar labile components using δ13C stable isotope technology. A sandy loam soil under a long-term rotation of C3 crops was amended with biochar produced from maize (a C4 plant straw in absence (BC0 and presence (BCN of N and monitored for dynamics of carbon dioxide (CO2 flux, phospholipid fatty acids (PLFAs profile and dissolved organic carbon (DOC content. N amendment significantly increased the decomposition of biochar during the first 5 days of incubation (P < 0.05, and the proportions of decomposed biochar carbon (C were 2.30% and 3.28% in BC0 and BCN treatments, respectively, during 30 days of incubation. The magnitude of decomposed biochar C was significantly (P < 0.05 higher than DOC in biochar (1.75% and part of relatively recalcitrant biochar C was mineralized in both treatments. N amendment increased soil PLFAs concentration at the beginning of incubation, indicating that microorganisms were N-limited in test soil. Furthermore, N amendment significantly (P < 0.05 increased the proportion of gram-positive (G+ bacteria and decreased that of fungi, while no noticeable changes were observed for gram-negative (G- bacteria and actinobacteria at the early stage of incubation. Our results indicated that N amendment promoted more efficiently the proliferation of G+ bacteria and accelerated the decomposition of relatively recalcitrant biochar C, which in turn reduced the stability of maize straw-derived biochar in test soil.

Education Pays, 2010: The Benefits of Higher Education for Individuals and Society. Trends in Higher Education Series

Science.gov (United States)

Baum, Sandy; Ma, Jennifer; Payea, Kathleen

2010-01-01

Students who attend institutions of higher education obtain a wide range of personal, financial, and other lifelong benefits; likewise, taxpayers and society as a whole derive a multitude of direct and indirect benefits when citizens have access to postsecondary education. Accordingly, uneven rates of participation in higher education across…

Source terms derived from analyses of hypothetical accidents, 1950-1986

International Nuclear Information System (INIS)

Stratton, W.R.

1987-01-01

This paper reviews the history of reactor accident source term assumptions. After the Three Mile Island accident, a number of theoretical and experimental studies re-examined possible accident sequences and source terms. Some of these results are summarized in this paper

17 CFR 240.16a-1 - Definition of terms.

Science.gov (United States)

2010-04-01

... to acquire equity securities through the exercise or conversion of any derivative security, whether... authority. (b) The term call equivalent position shall mean a derivative security position that increases in... security, a long call option, and a short put option position. (c) The term derivative securities shall...

Asymptotic formulae for the Lommel and Bessel functions and their derivatives.

Science.gov (United States)

Aleksandrova, N I

2014-10-01

We derive new approximate representations of the Lommel functions in terms of the Scorer function and approximate representations of the first derivative of the Lommel functions in terms of the derivative of the Scorer function. Using the same method, we obtain previously known approximate representations of the Nicholson type for Bessel functions and their first derivatives. We study also for what values of the parameters our representations have reasonable accuracy.

Banados-Teitelboim-Zanelli black hole with gravitational Chern-Simons term: Thermodynamics and statistical entropy

International Nuclear Information System (INIS)

Park, Mu-In

2008-01-01

Recently, the Banados-Teitelboim-Zanelli (BTZ) black hole in the presence of the gravitational Chern-Simons term has been studied, and it is found that the usual thermodynamic quantities, like the black hole mass, angular momentum, and entropy, are modified. But, for large values of the gravitational Chern-Simons coupling where the modification terms dominate the original terms some exotic behaviors occur, like the roles of the mass and angular momentum are interchanged and the entropy depends more on the inner horizon area than the outer one. A basic physical problem of this system is that the form of entropy does not guarantee the second law of thermodynamics, in contrast to the Bekenstein-Hawking entropy. Moreover, this entropy does not agree with the statistical entropy, in contrast to a good agreement for small values of the gravitational Chern-Simons coupling. Here I find that there is another entropy formula where the usual Bekenstein-Hawking form dominates the inner-horizon term again, as in the small gravitational Chern-Simons coupling case, such that the second law of thermodynamics can be guaranteed. I also find that the new entropy formula agrees with the statistical entropy based on the holographic anomalies for the whole range of the gravitational Chern-Simons coupling. This reproduces, in the limit of a vanishing Einstein-Hilbert term, the recent result about the exotic BTZ black holes, where their masses and angular momenta are completely interchanged and the entropies depend only on the area of the inner horizon. I compare the result of the holographic approach with the classical-symmetry-algebra-based approach, and I find exact agreements even with the higher-derivative corrections of the gravitational Chern-Simons term. This provides a nontrivial check of the AdS/CFT correspondence, in the presence of higher-derivative terms in the gravity action

A Study of Enhanced, Higher Order Boussinesq-Type Equations and Their Numerical Modelling

DEFF Research Database (Denmark)

Banijamali, Babak

model is designated for the solution of higher-order Boussinesq-type equations, formulated in terms of the horizontal velocity at an arbitrary depth vector. Various discretisation techniques and grid definitions have been considered in this endeavour, undertaking a detailed analysis of the selected......This project has encompassed efforts in two separate veins: on the one hand, the acquiring of highly accurate model equations of the Boussinesq-type, and on the other hand, the theoretical and practical work in implementing such equations in the form of conventional numerical models, with obvious...... potential for applications to the realm of numerical modelling in coastal engineering. The derivation and analysis of several forms of higher-order in dispersion and non-linearity Boussinesq-type equations have been undertaken, obtaining and investigating the properties of a new and generalised class...

Light-front higher-spin theories in flat space

Science.gov (United States)

Ponomarev, Dmitry; Skvortsov, Evgeny

2017-03-01

We revisit the problem of interactions of higher-spin fields in flat space. We argue that all no-go theorems can be avoided by the light-cone approach, which results in more interaction vertices as compared to the usual covariant approaches. It is stressed that there exist two-derivative gravitational couplings of higher-spin fields. We show that some reincarnation of the equivalence principle still holds for higher-spin fields—the strength of gravitational interaction does not depend on spin. Moreover, it follows from the results by Metsaev that there exists a complete chiral higher-spin theory in four dimensions. We give a simple derivation of this theory and show that the four-point scattering amplitude vanishes. Also, we reconstruct the quartic vertex of the scalar field in the unitary higher-spin theory, which turns out to be perturbatively local.

Light-front higher-spin theories in flat space

International Nuclear Information System (INIS)

Ponomarev, Dmitry; Skvortsov, Evgeny

2017-01-01

We revisit the problem of interactions of higher-spin fields in flat space. We argue that all no-go theorems can be avoided by the light-cone approach, which results in more interaction vertices as compared to the usual covariant approaches. It is stressed that there exist two-derivative gravitational couplings of higher-spin fields. We show that some reincarnation of the equivalence principle still holds for higher-spin fields—the strength of gravitational interaction does not depend on spin. Moreover, it follows from the results by Metsaev that there exists a complete chiral higher-spin theory in four dimensions. We give a simple derivation of this theory and show that the four-point scattering amplitude vanishes. Also, we reconstruct the quartic vertex of the scalar field in the unitary higher-spin theory, which turns out to be perturbatively local. (paper)

Higher Spin Superfield Interactions with the Chiral Supermultiplet: Conserved Supercurrents and Cubic Vertices

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Ioseph L. Buchbinder

2018-01-01

Full Text Available We investigate cubic interactions between a chiral superfield and higher spin superfields corresponding to irreducible representations of the 4 D , N = 1 super-Poincaré algebra. We do this by demanding an invariance under the most general transformation, linear in the chiral superfield. Following Noether’s method we construct an infinite tower of higher spin supercurrent multiplets which are quadratic in the chiral superfield and include higher derivatives. The results are that a single, massless, chiral superfield can couple only to the half-integer spin supermultiplets ( s + 1 , s + 1 / 2 and for every value of spin there is an appropriate improvement term that reduces the supercurrent multiplet to a minimal multiplet which matches that of superconformal higher spins. On the other hand a single, massive, chiral superfield can couple only to higher spin supermultiplets of type ( 2 l + 2 , 2 l + 3 / 2 (only odd values of s, s = 2 l + 1 and there is no minimal multiplet. Furthermore, for the massless case we discuss the component level higher spin currents and provide explicit expressions for the integer and half-integer spin conserved currents together with a R-symmetry current.

Irreversibility and higher-spin conformal field theory

Science.gov (United States)

Anselmi, Damiano

2000-08-01

I discuss the properties of the central charges c and a for higher-derivative and higher-spin theories (spin 2 included). Ordinary gravity does not admit a straightforward identification of c and a in the trace anomaly, because it is not conformal. On the other hand, higher-derivative theories can be conformal, but have negative c and a. A third possibility is to consider higher-spin conformal field theories. They are not unitary, but have a variety of interesting properties. Bosonic conformal tensors have a positive-definite action, equal to the square of a field strength, and a higher-derivative gauge invariance. There exists a conserved spin-2 current (not the canonical stress tensor) defining positive central charges c and a. I calculate the values of c and a and study the operator-product structure. Higher-spin conformal spinors have no gauge invariance, admit a standard definition of c and a and can be coupled to Abelian and non-Abelian gauge fields in a renormalizable way. At the quantum level, they contribute to the one-loop beta function with the same sign as ordinary matter, admit a conformal window and non-trivial interacting fixed points. There are composite operators of high spin and low dimension, which violate the Ferrara-Gatto-Grillo theorem. Finally, other theories, such as conformal antisymmetric tensors, exhibit more severe internal problems. This research is motivated by the idea that fundamental quantum field theories should be renormalization-group (RG) interpolations between ultraviolet and infrared conformal fixed points, and quantum irreversibility should be a general principle of nature.

Happiness in Higher Education

Science.gov (United States)

Elwick, Alex; Cannizzaro, Sara

2017-01-01

This paper investigates the higher education literature surrounding happiness and related notions: satisfaction, despair, flourishing and well-being. It finds that there is a real dearth of literature relating to profound happiness in higher education: much of the literature using the terms happiness and satisfaction interchangeably as if one were…

45 CFR 1630.12 - Applicability to derivative income.

Science.gov (United States)

2010-10-01

..., regulations, guidelines, and instructions, the Accounting Guide for LSC recipients, the terms and conditions... 45 Public Welfare 4 2010-10-01 2010-10-01 false Applicability to derivative income. 1630.12... CORPORATION COST STANDARDS AND PROCEDURES § 1630.12 Applicability to derivative income. (a) Derivative income...

Early and long-term mantle processing rates derived from xenon isotopes

Science.gov (United States)

Mukhopadhyay, S.; Parai, R.; Tucker, J.; Middleton, J. L.; Langmuir, C. H.

2015-12-01

Noble gases, particularly xenon (Xe), in mantle-derived basalts provide a rich portrait of mantle degassing and surface-interior volatile exchange. The combination of extinct and extant radioactive species in the I-Pu-U-Xe systems shed light on the degassing history of the early Earth throughout accretion, as well as the long-term degassing of the Earth's interior in association with plate tectonics. The ubiquitous presence of shallow-level air contamination, however, frequently obscures the mantle Xe signal. In a majority of the samples, shallow air contamination dominates the Xe budget. For example, in the gas-rich popping rock 2ΠD43, 129Xe/130Xe ratios reach 7.7±0.23 in individual step-crushes, but the bulk composition of the sample is close to air (129Xe/130Xe of 6.7). Thus, the extent of variability in mantle source Xe composition is not well-constrained. Here, we present new MORB Xe data and explore constraints placed on mantle processing rates by the Xe data. Ten step-crushes were obtained on a depleted popping glass that was sealed in ultrapure N2 after dredge retrieval from between the Kane-Atlantis Fracture Zone of the Mid Atlantic Ridge in May 2012. 9 steps yielded 129Xe/130Xe of 7.50-7.67 and one yielded 7.3. The bulk 129Xe/130Xe of the sample is 7.6, nearly identical to the estimated mantle source value of 7.7 for the sample. Hence, the sample is virtually free of shallow-level air contamination. Because sealing the sample in N2upon dredge retrieval largely eliminated air contamination, for many samples, contamination must be added after sample retrieval from the ocean bottom. Our new high-precision Xe isotopic measurements in upper mantle-derived samples provide improved constraints on the Xe isotopic composition of the mantle source. We developed a forward model of mantle volatile evolution to identify solutions that satisfy our Xe isotopic data. We find that accretion timescales of ~10±5 Myr are consistent with I-Pu-Xe constraints, and the last

Higher-twist effects in the B → π transition form factor from QCD light-cone sum rules

Energy Technology Data Exchange (ETDEWEB)

Khodjamirian, Alexander; Rusov, Aleksey [Universitaet Siegen (Germany). Fakultaet IV, Department Physik, Theoretische Physik 1 Walter-Flex-Strasse 3 57068 Siegen

2016-07-01

I report on the progress in calculating new higher-twist corrections to the QCD light-cone sum rule for the B → π transition form factor. First, the expansion of the massive heavy-quark propagator in the external gluonic field near the light-cone was extended to include new terms containing the gluon-field strength derivatives. The resulting analytical expressions for the twist-5 and twist-6 contributions to the correlation function were obtained in a factorized approximation, expressed via the product of the quark-condensate density and the lower-twist pion distribution amplitudes. The numerical analysis of new higher-twist effects is in progress.

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.

Science.gov (United States)

Tasev, Dimitar; van Wijhe, Michiel H; Weijers, Ester M; van Hinsbergh, Victor W M; Koolwijk, Pieter

2015-01-01

Efficient implementation of peripheral blood-derived endothelial-colony cells (PB-ECFCs) as a therapeutical tool requires isolation and generation of a sufficient number of cells in ex vivo conditions devoid of animal-derived products. At present, little is known how the isolation and expansion procedure in xenogeneic-free conditions affects the therapeutical capacity of PB-ECFCs. The findings presented in this study indicate that human platelet lysate (PL) as a serum substitute yields twice more colonies per mL blood compared to the conventional isolation with fetal bovine serum (FBS). Isolated ECFCs displayed a higher proliferative ability in PL supplemented medium than cells in FBS medium during 30 days expansion. The cells at 18 cumulative population doubling levels (CPDL) retained their proliferative capacity, showed higher sprouting ability in fibrin matrices upon stimulation with FGF-2 and VEGF-A than the cells at 6 CPDL, and displayed low β-galactosidase activity. The increased sprouting of PB-ECFCs at 18 CPDL was accompanied by an intrinsic activation of the uPA/uPAR fibrinolytic system. Induced deficiency of uPA (urokinase-type plasminogen activator) or uPAR (uPA receptor) by siRNA technology completely abolished the angiogenic ability of PB-ECFCs in fibrin matrices. During the serial expansion, the gene induction of the markers associated with inflammatory activation such as VCAM-1 and ICAM-1 did not occur or only to limited extent. While further propagation up to 31 CPDL proceeded at a comparable rate, a marked upregulation of inflammatory markers occurred in all donors accompanied by a further increase of uPA/uPAR gene induction. The observed induction of inflammatory genes at later stages of long-term propagation of PB-ECFCs underpins the necessity to determine the right time-point for harvesting of sufficient number of cells with preserved therapeutical potential. The presented isolation method and subsequent cell expansion in platelet lysate

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.

Directory of Open Access Journals (Sweden)

Dimitar Tasev

Full Text Available Efficient implementation of peripheral blood-derived endothelial-colony cells (PB-ECFCs as a therapeutical tool requires isolation and generation of a sufficient number of cells in ex vivo conditions devoid of animal-derived products. At present, little is known how the isolation and expansion procedure in xenogeneic-free conditions affects the therapeutical capacity of PB-ECFCs.The findings presented in this study indicate that human platelet lysate (PL as a serum substitute yields twice more colonies per mL blood compared to the conventional isolation with fetal bovine serum (FBS. Isolated ECFCs displayed a higher proliferative ability in PL supplemented medium than cells in FBS medium during 30 days expansion. The cells at 18 cumulative population doubling levels (CPDL retained their proliferative capacity, showed higher sprouting ability in fibrin matrices upon stimulation with FGF-2 and VEGF-A than the cells at 6 CPDL, and displayed low β-galactosidase activity. The increased sprouting of PB-ECFCs at 18 CPDL was accompanied by an intrinsic activation of the uPA/uPAR fibrinolytic system. Induced deficiency of uPA (urokinase-type plasminogen activator or uPAR (uPA receptor by siRNA technology completely abolished the angiogenic ability of PB-ECFCs in fibrin matrices. During the serial expansion, the gene induction of the markers associated with inflammatory activation such as VCAM-1 and ICAM-1 did not occur or only to limited extent. While further propagation up to 31 CPDL proceeded at a comparable rate, a marked upregulation of inflammatory markers occurred in all donors accompanied by a further increase of uPA/uPAR gene induction. The observed induction of inflammatory genes at later stages of long-term propagation of PB-ECFCs underpins the necessity to determine the right time-point for harvesting of sufficient number of cells with preserved therapeutical potential.The presented isolation method and subsequent cell expansion in platelet

Higher-Order Generalized Invexity in Control Problems

Directory of Open Access Journals (Sweden)

S. K. Padhan

2011-01-01

Full Text Available We introduce a higher-order duality (Mangasarian type and Mond-Weir type for the control problem. Under the higher-order generalized invexity assumptions on the functions that compose the primal problems, higher-order duality results (weak duality, strong duality, and converse duality are derived for these pair of problems. Also, we establish few examples in support of our investigation.

Effect of chondrocyte-derived early extracellular matrix on chondrogenesis of placenta-derived mesenchymal stem cells.

Science.gov (United States)

Park, Yong-Beom; Seo, Sinji; Kim, Jin-A; Heo, Jin-Chul; Lim, Young-Cheol; Ha, Chul-Won

2015-06-24

The extracellular matrix (ECM) surrounding cells contains a variety of proteins that provide structural support and regulate cellular functions. Previous studies have shown that decellularized ECM isolated from tissues or cultured cells can be used to improve cell differentiation in tissue engineering applications. In this study we evaluated the effect of decellularized chondrocyte-derived ECM (CDECM) on the chondrogenesis of human placenta-derived mesenchymal stem cells (hPDMSCs) in a pellet culture system. After incubation with or without chondrocyte-derived ECM in chondrogenic medium for 1 or 3 weeks, the sizes and wet masses of the cell pellets were compared with untreated controls (hPDMSCs incubated in chondrogenic medium without chondrocyte-derived ECM). In addition, histologic analysis of the cell pellets (Safranin O and collagen type II staining) and quantitative reverse transcription-PCR analysis of chondrogenic markers (aggrecan, collagen type II, and SOX9) were carried out. Our results showed that the sizes and masses of hPDMSC pellets incubated with chondrocyte-derived ECM were significantly higher than those of untreated controls. Differentiation of hPDMSCs (both with and without chondrocyte-derived ECM) was confirmed by Safranin O and collagen type II staining. Chondrogenic marker expression and glycosaminoglycan (GAG) levels were significantly higher in hPDMSC pellets incubated with chondrocyte-derived ECM compared with untreated controls, especially in cells precultured with chondrocyte-derived ECM for 7 d. Taken together, these results demonstrate that chondrocyte-derived ECM enhances the chondrogenesis of hPDMSCs, and this effect is further increased by preculture with chondrocyte-derived ECM. This preculture method for hPDMSC chondrogenesis represents a promising approach for cartilage tissue engineering.

Monitoring and inspection techniques for long term storage of higher activity waste packages

International Nuclear Information System (INIS)

Bolton, Gary

2013-01-01

In 2009, following recent changes in United Kingdom (UK) Government Policy, the Nuclear Decommissioning Authority (NDA) identified a knowledge gap in the area of long term interim storage of waste packages. A cross-industry Integrated Project Team (IPT) for Interim Storage was created with responsibility for delivering Industry Guidance on the storage of packaged Higher Activity Waste (HAW) for the current UK civil decommissioning and clean-up programmes. This included a remit to direct research and development projects via the NDA's Direct Research Portfolio (DRP) to fill the knowledge gap. The IPT for Interim Storage published Industry Guidance in 2012 which established a method to define generic package performance criteria and made recommendations on monitoring and inspection. The package performance method consists of the following steps; identification of the package safety function, identification of evolutionary processes that may affect safety function performance, determination of measurable indicators of these evolutionary processes and calibration of the indicators into package performance zones. This article provides an overview of three projects funded by the NDA's DRP that the UK National Nuclear Laboratory (NNL) have completed to address monitoring and inspection needs of waste packages in interim storage. (orig.)

Novel polybenzimidazole derivatives for high temperature polymer electrolyte membrane fuel cell applications

Science.gov (United States)

Xiao, Lixiang

Recent advances have made polymer electrolyte membrane fuel cells (PEMFCs) a leading alternative to internal combustion engines for both stationary and transportation applications. In particular, high temperature polymer electrolyte membranes operational above 120°C without humidification offer many advantages including fast electrode kinetics, high tolerance to fuel impurities and simple thermal and water management systems. A series of polybenzimidazole (PBI) derivatives including pyridine-based PBI (PPBI) and sulfonated PBI (SPBI) homopolymers and copolymers have been synthesized using polyphosphoric acid (PPA) as both solvent and polycondensation agent. High molecular weight PBI derivative polymers were obtained with well controlled backbone structures in terms of pyridine ring content, polymer backbone rigidity and degree of sulfonation. A novel process, termed the PPA process, has been developed to prepare phosphoric acid (PA) doped PBI membranes by direct-casting of the PPA polymerization solution without isolation or re-dissolution of the polymers. The subsequent hydrolysis of PPA to PA by moisture absorbed from the atmosphere usually induced a transition from the solution-like state to a gel-like state and produced PA doped PBI membranes with a desirable suite of physiochemical properties characterized by the PA doping levels, mechanical properties and proton conductivities. The effects of the polymer backbone structure on the polymer characteristics and membrane properties, i.e., the structure-property relationships of the PBI derivative polymers have been studied. The incorporation of additional basic nitrogen containing pyridine rings and sulfonic acid groups enhanced the polymer solubility in acid and dipolar solvents while retaining the inherently high thermal stability of the PBI heteroaromatic backbone. In particular, the degradation of the SPBI polymers with reasonable high molecular weights commenced above 450°C, notably higher than other

Distribution of Short-Term and Lifetime Predicted Risks of Cardiovascular Diseases in Peruvian Adults

Science.gov (United States)

Quispe, Renato; Bazo-Alvarez, Juan Carlos; Burroughs Peña, Melissa S; Poterico, Julio A; Gilman, Robert H; Checkley, William; Bernabé-Ortiz, Antonio; Huffman, Mark D; Miranda, J Jaime

2015-01-01

Background Short-term risk assessment tools for prediction of cardiovascular disease events are widely recommended in clinical practice and are used largely for single time-point estimations; however, persons with low predicted short-term risk may have higher risks across longer time horizons. Methods and Results We estimated short-term and lifetime cardiovascular disease risk in a pooled population from 2 studies of Peruvian populations. Short-term risk was estimated using the atherosclerotic cardiovascular disease Pooled Cohort Risk Equations. Lifetime risk was evaluated using the algorithm derived from the Framingham Heart Study cohort. Using previously published thresholds, participants were classified into 3 categories: low short-term and low lifetime risk, low short-term and high lifetime risk, and high short-term predicted risk. We also compared the distribution of these risk profiles across educational level, wealth index, and place of residence. We included 2844 participants (50% men, mean age 55.9 years [SD 10.2 years]) in the analysis. Approximately 1 of every 3 participants (34% [95% CI 33 to 36]) had a high short-term estimated cardiovascular disease risk. Among those with a low short-term predicted risk, more than half (54% [95% CI 52 to 56]) had a high lifetime predicted risk. Short-term and lifetime predicted risks were higher for participants with lower versus higher wealth indexes and educational levels and for those living in urban versus rural areas (PPeruvian adults were classified as low short-term risk but high lifetime risk. Vulnerable adults, such as those from low socioeconomic status and those living in urban areas, may need greater attention regarding cardiovascular preventive strategies. PMID:26254303

Land Use Alters the Plant-Derived Carbon and Nitrogen Pools in Terraced Rice Paddies in a Mountain Village

Directory of Open Access Journals (Sweden)

Seiji Shimoda

2017-10-01

Full Text Available In Japan, terraced paddies in mountain villages are symbolic of the traditional landscape, but they are gradually being abandoned. To compare plant-derived C and N among land uses, we compared adjacent forest floor (FF, agricultural paddy (AP, and post-agricultural paddy (PP sites. Long-term litter accumulation could explain the significantly higher litter C and belowground biomass C in FF than in AP and PP. The low-density-fraction (LF soil C was significantly higher in FF than in PP and better reflected land use than the whole-soil C. The AP soil held more N than FF and PP at 20–30 cm, associated with higher LF soil N. Periodic tillage in AP maintains the LF soil N, but N supplied to the surface soil reduced with depth following abandonment. Differences in recycling of organic matter and nutrients among land uses are crucial to plant-derived C and N contents of soil.

Entropy for gravitational Chern-Simons terms by squashed cone method

International Nuclear Information System (INIS)

Guo, Wu-Zhong; Miao, Rong-Xin

2016-01-01

In this paper we investigate the entropy of gravitational Chern-Simons terms for the horizon with non-vanishing extrinsic curvatures, or the holographic entanglement entropy for arbitrary entangling surface. In 3D there is no anomaly of entropy. But the original squashed cone method can not be used directly to get the correct result. For higher dimensions the anomaly of entropy would appear, still, we can not use the squashed cone method directly. That is becasuse the Chern-Simons action is not gauge invariant. To get a reasonable result we suggest two methods. One is by adding a boundary term to recover the gauge invariance. This boundary term can be derived from the variation of the Chern-Simons action. The other one is by using the Chern-Simons relation dΩ_4_n_−_1=tr(R"2"n). We notice that the entropy of tr(R"2"n) is a total derivative locally, i.e. S=ds_C_S. We propose to identify s_C_S with the entropy of gravitational Chern-Simons terms Ω_4_n_−_1. In the first method we could get the correct result for Wald entropy in arbitrary dimension. In the second approach, in addition to Wald entropy, we can also obtain the anomaly of entropy with non-zero extrinsic curvatures. Our results imply that the entropy of a topological invariant, such as the Pontryagin term tr(R"2"n) and the Euler density, is a topological invariant on the entangling surface.

Derivative chameleons

International Nuclear Information System (INIS)

Noller, Johannes

2012-01-01

We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂ μ φ∂ μ φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂ μ φ∂ μ φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type

Derivative chameleons

Energy Technology Data Exchange (ETDEWEB)

Noller, Johannes, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics, Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2BZ (United Kingdom)

2012-07-01

We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂{sub μ}φ∂{sup μ}φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂{sub μ}φ∂{sup μ}φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.

Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors

International Nuclear Information System (INIS)

Colleoni, Silvia; Galli, Cesare; Giannelli, Serena G.; Armentero, Marie-Therese; Blandini, Fabio; Broccoli, Vania; Lazzari, Giovanna

2010-01-01

In this study we demonstrated that neural rosettes derived from human ES cells can give rise either to neural crest precursors, following expansion in presence of bFGF and EGF, or to dopaminergic precursors after exposure to ventralizing factors Shh and FGF8. Both regionalised precursors are capable of extensive proliferation and differentiation towards the corresponding terminally differentiated cell types. In particular, peripheral neurons, cartilage, bone, smooth muscle cells and also pigmented cells were obtained from neural crest precursors while tyrosine hydroxylase and Nurr1 positive dopaminergic neurons were derived from FGF8 and Shh primed rosette cells. Gene expression and immunocytochemistry analyses confirmed the expression of dorsal and neural crest genes such as Sox10, Slug, p75, FoxD3, Pax7 in neural precursors from bFGF-EGF exposed rosettes. By contrast, priming of rosettes with FGF8 and Shh induced the expression of dopaminergic markers Engrailed1, Pax2, Pitx3, floor plate marker FoxA2 and radial glia markers Blbp and Glast, the latter in agreement with the origin of dopaminergic precursors from floor plate radial glia. Moreover, in vivo transplant of proliferating Shh/FGF8 primed precursors in parkinsonian rats demonstrated engraftment and terminal dopaminergic differentiation. In conclusion, we demonstrated the derivation of long-term self-renewing precursors of selected regional identity as potential cell reservoirs for cell therapy applications, such as CNS degenerative diseases, or for the development of toxicological tests.

Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors

Energy Technology Data Exchange (ETDEWEB)

Colleoni, Silvia, E-mail: silviacolleoni@avantea.it [Laboratorio di Tecnologie della Riproduzione, Avantea, Via Porcellasco 7/f, 26100 Cremona (Italy); Galli, Cesare [Laboratorio di Tecnologie della Riproduzione, Avantea, Via Porcellasco 7/f, 26100 Cremona (Italy); Dipartimento Clinico Veterinario, Universita di Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia (Italy); Giannelli, Serena G. [Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan (Italy); Armentero, Marie-Therese; Blandini, Fabio [Laboratory of Functional Neurochemistry, Interdepartmental Research Center for Parkinson' s Disease, Neurological Institute C. Mondino, Via Mondino 2, 27100 Pavia (Italy); Broccoli, Vania, E-mail: broccoli.vania@hsr.it [Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan (Italy); Lazzari, Giovanna, E-mail: giovannalazzari@avantea.it [Laboratorio di Tecnologie della Riproduzione, Avantea, Via Porcellasco 7/f, 26100 Cremona (Italy)

2010-04-15

In this study we demonstrated that neural rosettes derived from human ES cells can give rise either to neural crest precursors, following expansion in presence of bFGF and EGF, or to dopaminergic precursors after exposure to ventralizing factors Shh and FGF8. Both regionalised precursors are capable of extensive proliferation and differentiation towards the corresponding terminally differentiated cell types. In particular, peripheral neurons, cartilage, bone, smooth muscle cells and also pigmented cells were obtained from neural crest precursors while tyrosine hydroxylase and Nurr1 positive dopaminergic neurons were derived from FGF8 and Shh primed rosette cells. Gene expression and immunocytochemistry analyses confirmed the expression of dorsal and neural crest genes such as Sox10, Slug, p75, FoxD3, Pax7 in neural precursors from bFGF-EGF exposed rosettes. By contrast, priming of rosettes with FGF8 and Shh induced the expression of dopaminergic markers Engrailed1, Pax2, Pitx3, floor plate marker FoxA2 and radial glia markers Blbp and Glast, the latter in agreement with the origin of dopaminergic precursors from floor plate radial glia. Moreover, in vivo transplant of proliferating Shh/FGF8 primed precursors in parkinsonian rats demonstrated engraftment and terminal dopaminergic differentiation. In conclusion, we demonstrated the derivation of long-term self-renewing precursors of selected regional identity as potential cell reservoirs for cell therapy applications, such as CNS degenerative diseases, or for the development of toxicological tests.

Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.

Science.gov (United States)

Diao, Yanpeng; Guthrie, Steve; Xia, Shen-Ling; Ouyang, Xiaosen; Zhang, Li; Xue, Jing; Lee, Pui; Grant, Maria; Scott, Edward; Segal, Mark S

2008-03-01

Intimal hyperplasia of autologous vein grafts is a critical problem affecting the long-term patency of many types of vascular reconstruction. Within intimal hyperplasia lesions, smooth muscle cells are a major component, playing an essential role in the pathological process. Given that bone marrow-derived cells may differentiate into smooth muscle cells in the neointima of injured arteries, we hypothesized that the bone marrow may serve as a source for some of the smooth muscle cells within intimal hyperplasia lesions of vein grafts. To test this hypothesis, we used an established mouse model for intimal hyperplasia in wild-type mice that had been transplanted with bone marrow from a green fluorescent protein (GFP+/+) transgenic mouse. High-resolution confocal microscopy analysis performed 2 and 8 weeks after grafting demonstrated expression of GFP in 5.4 +/- 0.8% and 11.9 +/- 2.3%, respectively, of smooth muscle cells within intimal hyperplasia lesions. By 16 weeks, GFP expression in smooth muscle cells was not detected by immunohistochemistry; however, real-time PCR revealed that 20.2 +/- 1.7% of the smooth muscle cells captured from the neointima lesion by laser capture microdissection at 16 weeks contained GFP DNA. Our results suggest that bone marrow-derived cells differentiated into smooth muscle cells within the intimal lesion and may provide a novel clinical approach for decreasing intimal hyperplasia in vein grafts.

Solid-state one-way photoisomerisation of Z,E,Z-1,6-(4,4'-diphenyl)hexa-1,3,5-triene dicarboxylate examined using higher-order derivative spectra and powder XRD patterns.

Science.gov (United States)

Sonoda, Yoriko; Goto, Midori; Ichimura, Kunihiro

2018-03-14

Higher order derivative spectra were applied at first to one-way ZEZ-to-EEE photoisomerisation of dimethyl ester (ZEZ-DPH1) of the titled compound in a methylcyclohexane solution. Many common crossing points emerged in UV-induced derivative-spectral changes to reveal the direct ZEZ-to-EEE photoisomerisation without the transient formation of an intermediate to suggest the bicycle-pedal mechanism. The solid-state photoisomerisation was subsequently monitored by tracing changes in the fourth-order derivatives of absorption spectra of a thin crystalline layer of ZEZ-DPH1 prepared by the drop-casting method, because the distortion of absorption spectra due to light scattering is cancelled. It was suggested that the solid-state photochemical event consists of three steps: fast ZEZ-to-EEE photoisomerisation, a subsequent slow ZEZ-to-EEE photoisomerisation and very slow disappearance of the EEE-isomer. Studies on powder XRD were also carried out for a drop-cast solid layer of ZEZ-DPH1 to disclose the coexistence of a crystal form other than the original one, and the former exhibited faster ZEZ-to-EEE photoisomerisation when compared with the original crystal form. The results revealed by XRD analysis are in line with those obtained by higher-order derivative spectra, confirming the solid-state one-way photoisomerisation to take place through the bicycle-pedal process.

Long-term variation of outdoor radon equilibrium equivalent concentration

Energy Technology Data Exchange (ETDEWEB)

Hoetzl, H. [GSF-Forschungszentrum fuer Umwelt und Gesundheit, Inst. fuer Strahlenschutz, Oberschleissheim (Germany); Winkler, R. [GSF-Forschungszentrum fuer Umwelt und Gesundheit, Inst. fuer Strahlenschutz, Oberschleissheim (Germany)

1994-10-01

Long-term variation of outdoor radon equilibrium equivalent concentration was investigated from 1982 to 1992 at a semi-natural location 10 km north of Munich, southern Germany. For this period the continuous measurement yielded a long-term average of 8.6 Bq.m{sup -3} (arithmetic mean) and 6.9 Bq.m{sup -3} (geometric mean), from which an average annual effective dose of 0.14 mSv due to outdoor radon can be derived. A long-term trend of the radon concentration was not detectable over the whole period of observation. However, by time series analysis, a long-term cyclic pattern was identified with two maxima (1984-1986, 1989-1991) and two minima (1982-1983, 1987-1988). The seasonal pattern is characterized by an autumn maximum and an early summer minimum. On average, the seasonal maximum in October was found to be higher by a factor of 2 than the June minimum. The diurnal variation of the radon concentration shows a maximum in the early morning and a minimum in the afternoon. On average, this maximum is a factor of 2 higher than the minimum. In the long term a seasonal pattern was observed for diurnal variation, with an average diurnal maximum to minimum ratio of 1.5 in winter compared with 3.5 in the summer months. The radon concentration is correlated with a meteorological parameter (stagnation index) which takes into account horizontal and vertical exchange processes and the wash-out of aerosols in the lower atmosphere. (orig.)

Long-term variation of outdoor radon equilibrium equivalent concentration

International Nuclear Information System (INIS)

Hoetzl, H.; Winkler, R.

1994-01-01

Long-term variation of outdoor radon equilibrium equivalent concentration was investigated from 1982 to 1992 at a semi-natural location 10 km north of Munich, southern Germany. For this period the continuous measurement yielded a long-term average of 8.6 Bq.m -3 (arithmetic mean) and 6.9 Bq.m -3 (geometric mean), from which an average annual effective dose of 0.14 mSv due to outdoor radon can be derived. A long-term trend of the radon concentration was not detectable over the whole period of observation. However, by time series analysis, a long-term cyclic pattern was identified with two maxima (1984-1986, 1989-1991) and two minima (1982-1983, 1987-1988). The seasonal pattern is characterized by an autumn maximum and an early summer minimum. On average, the seasonal maximum in October was found to be higher by a factor of 2 than the June minimum. The diurnal variation of the radon concentration shows a maximum in the early morning and a minimum in the afternoon. On average, this maximum is a factor of 2 higher than the minimum. In the long term a seasonal pattern was observed for diurnal variation, with an average diurnal maximum to minimum ratio of 1.5 in winter compared with 3.5 in the summer months. The radon concentration is correlated with a meteorological parameter (stagnation index) which takes into account horizontal and vertical exchange processes and the wash-out of aerosols in the lower atmosphere. (orig.)

Distribution of Short-Term and Lifetime Predicted Risks of Cardiovascular Diseases in Peruvian Adults.

Science.gov (United States)

Quispe, Renato; Bazo-Alvarez, Juan Carlos; Burroughs Peña, Melissa S; Poterico, Julio A; Gilman, Robert H; Checkley, William; Bernabé-Ortiz, Antonio; Huffman, Mark D; Miranda, J Jaime

2015-08-07

Short-term risk assessment tools for prediction of cardiovascular disease events are widely recommended in clinical practice and are used largely for single time-point estimations; however, persons with low predicted short-term risk may have higher risks across longer time horizons. We estimated short-term and lifetime cardiovascular disease risk in a pooled population from 2 studies of Peruvian populations. Short-term risk was estimated using the atherosclerotic cardiovascular disease Pooled Cohort Risk Equations. Lifetime risk was evaluated using the algorithm derived from the Framingham Heart Study cohort. Using previously published thresholds, participants were classified into 3 categories: low short-term and low lifetime risk, low short-term and high lifetime risk, and high short-term predicted risk. We also compared the distribution of these risk profiles across educational level, wealth index, and place of residence. We included 2844 participants (50% men, mean age 55.9 years [SD 10.2 years]) in the analysis. Approximately 1 of every 3 participants (34% [95% CI 33 to 36]) had a high short-term estimated cardiovascular disease risk. Among those with a low short-term predicted risk, more than half (54% [95% CI 52 to 56]) had a high lifetime predicted risk. Short-term and lifetime predicted risks were higher for participants with lower versus higher wealth indexes and educational levels and for those living in urban versus rural areas (PPeruvian adults were classified as low short-term risk but high lifetime risk. Vulnerable adults, such as those from low socioeconomic status and those living in urban areas, may need greater attention regarding cardiovascular preventive strategies. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Optoelectronic properties of higher acenes, their BN analogue and substituted derivatives

International Nuclear Information System (INIS)

Armaković, Stevan; Armaković, Sanja J.; Holodkov, Vladimir; Pelemiš, Svetlana

2016-01-01

We have investigated optoelectronic properties of higher acenes: pentacene, hexacene, heptacene, octacene, nonacene, decacene and their boron-nitride (BN) analogues, within the framework of density functional theory (DFT). We have also investigated the optoelectronic properties of acenes modified by BN substitution. Calculated optoelectronic properties encompasses: oxidation and reduction potentials, electron and hole reorganization energies and energy difference between excited first singlet and triplet states ΔE(S_1−T_1). Oxidation and reduction potentials indicate significantly better stability of BN analogues, comparing with their all-carbon relatives. Although higher acenes possess lower electron and hole reorganization energies, with both best values much lower than 0.1 eV, their BN analogues also have competitive values of reorganization energies, especially for holes for which reorganization energy is also lower than 0.1 eV. On the other hand ΔE(S_1−T_1) is much better for BN analogues, having values that indicate that BN analogues are possible applicable for thermally activated delayed fluorescence. - Highlights: • Optoelectronic properties of structures based on higher acenes have been investigated. • Oxidation and reduction potentials together with reorganization energies are calculated. • TADF is analyzed through calculation of ΔE(S_1−T_1), which is much better for BN analogues. • Reorganization energies of acenes improve with the increase of number of benzene rings.

Thermodynamics of higher spin black holes in AdS3

Science.gov (United States)

de Boer, Jan; Jottar, Juan I.

2014-01-01

We discuss the thermodynamics of recently constructed three-dimensional higher spin black holes in SL( N, ) × SL( N, ) Chern-Simons theory with generalized asymptotically-anti-de Sitter boundary conditions. From a holographic perspective, these bulk theories are dual to two-dimensional CFTs with WN symmetry algebras, and the black hole solutions are dual to thermal states with higher spin chemical potentials and charges turned on. Because the notion of horizon area is not gauge-invariant in the higher spin theory, the traditional approaches to the computation of black hole entropy must be reconsidered. One possibility, explored in the recent literature, involves demanding the existence of a partition function in the CFT, and consistency with the first law of thermodynamics. This approach is not free from ambiguities, however, and in particular different definitions of energy result in different expressions for the entropy. In the present work we show that there are natural definitions of the thermodynamically conjugate variables that follow from careful examination of the variational principle, and moreover agree with those obtained via canonical methods. Building on this intuition, we derive general expressions for the higher spin black hole entropy and free energy which are written entirely in terms of the Chern-Simons connections, and are valid for both static and rotating solutions. We compare our results to other proposals in the literature, and provide a new and efficient way to determine the generalization of the Cardy formula to a situation with higher spin charges.

Health status among long-term breast cancer survivors suffering from higher levels of fatigue: a cross-sectional study.

Science.gov (United States)

Álvarez-Salvago, Francisco; Galiano-Castillo, Noelia; Arroyo-Morales, Manuel; Cruz-Fernández, Mayra; Lozano-Lozano, Mario; Cantarero-Villanueva, Irene

2018-05-05

The aims of this study were to evaluate the health status of long-term breast cancer survivors (LTBCS) suffering from higher levels of fatigue, to highlight their needs, and to establish the key points of intervention support programs. A cross-sectional observational study was conducted at the Sport and Health Joint University Institute (iMUDS) between September 2016 and July 2017 with 80 LTBCS that were classified into non-fatigued (≤ 3.9) or fatigued (≥ 4) according to the Piper Fatigue Scale (PFS) total score. The instruments used were the European Organization for Research and Treatment of Cancer Core 30 and its breast cancer (BC) module, the Visual Analog Scale (VAS), the Brief Pain Inventory (BPI), the Scale for Mood Assessment (EVEA), the International Fitness Scale (IFIS), and the Charlson Comorbidity Index. The analysis revealed that 41.2% of LTBCS were considered moderately fatigued and showed significantly higher levels for the categories of "nausea and vomiting" (P = .005), "pain," "dyspnea" and "insomnia" (P < .001), "appetite loss" (P = .002), "financial difficulties" (P = .010), "systemic therapy side effects" (P < .001), "breast symptoms" and "arm symptoms" (P = .002), and "upset by hair loss" (P = .016). In addition, LTBCS presented significantly higher levels of pain in the affected and non-affected arm, "sadness-depression." "anxiety," "anger/hostility" (All: P < .001), and lower general physical fitness (P < .001). The rest of the variables did not show significant differences. LTBCS suffering from higher levels of fatigue had lower QoL, higher level of pain, worse mood state, and lower physical fitness.

Random walk term weighting for information retrieval

DEFF Research Database (Denmark)

Blanco, R.; Lioma, Christina

2007-01-01

We present a way of estimating term weights for Information Retrieval (IR), using term co-occurrence as a measure of dependency between terms.We use the random walk graph-based ranking algorithm on a graph that encodes terms and co-occurrence dependencies in text, from which we derive term weights...

"Nonmorphological Derivations" and the Four Main English ...

African Journals Online (AJOL)

This article addresses the problem of "nonmorphological derivations" in English and its consequences for pedagogical lexicography, i.e. learner's dictionaries. The term "nonmorphological derivation" refers to cases such as sun — solar, moon — lunar, cat — feline, and in general to all cases where instead of, or in addition ...

'Luck, chance, and happenstance? Perceptions of success and failure amongst fixed-term academic staff in UK higher education'.

Science.gov (United States)

Loveday, Vik

2017-09-07

What does it mean to attribute success to 'luck', but failure to personal deficiency? In 2015/16, more than 34 per cent of academic employees in UK higher education institutions were employed on temporary contracts, and the sector itself has undergone a substantial transformation in recent years in terms of expansion, measurement, and marketization. Based on two waves of interviews conducted with fixed-term academic employees at different career stages, the article explores the narrativization of success and failure amongst staff working at the 'sharp end' of the so-called neoliberal academy. Arguing that precarious employment situations precipitate the feeling of being 'out of control', the majority of the participants' narratives were characterized by a distinct lack of agency. The paper explores the recourse to notions of chance and the consolidation of 'luck' as an explanatory factor in accounting for why good things happen; however, in tandem with this inclination is the tendency to individualize failure when expectations have been thwarted. While accounts of fixed-term work are suffused with notions of chance and fortune, 'luck' remains an under-researched concept within sociology. The article thus concludes by considering what the analysis of 'luck' might offer for a fuller, politicized understanding of processes at work in the contemporary academy. © London School of Economics and Political Science 2017.

Higher dimensional quantum Hall effect as A-class topological insulator

Energy Technology Data Exchange (ETDEWEB)

Hasebe, Kazuki, E-mail: khasebe@stanford.edu

2014-09-15

We perform a detail study of higher dimensional quantum Hall effects and A-class topological insulators with emphasis on their relations to non-commutative geometry. There are two different formulations of non-commutative geometry for higher dimensional fuzzy spheres: the ordinary commutator formulation and quantum Nambu bracket formulation. Corresponding to these formulations, we introduce two kinds of monopole gauge fields: non-abelian gauge field and antisymmetric tensor gauge field, which respectively realize the non-commutative geometry of fuzzy sphere in the lowest Landau level. We establish connection between the two types of monopole gauge fields through Chern–Simons term, and derive explicit form of tensor monopole gauge fields with higher string-like singularity. The connection between two types of monopole is applied to generalize the concept of flux attachment in quantum Hall effect to A-class topological insulator. We propose tensor type Chern–Simons theory as the effective field theory for membranes in A-class topological insulators. Membranes turn out to be fractionally charged objects and the phase entanglement mediated by tensor gauge field transforms the membrane statistics to be anyonic. The index theorem supports the dimensional hierarchy of A-class topological insulator. Analogies to D-brane physics of string theory are discussed too.

Vykazování finančních derivátů

OpenAIRE

Votoček, Filip

2009-01-01

Thesis is devoted to basic aspects of the reporting of financial derivatives. Mentioned is brief history and determination of term "derivative" from different points of view. Follows diversification of financial derivatives into groups. The main part is focused on reporting of fixed term contracts and options. Finally is described approach of International Financial Reporting Standards.

Systematic studies of molecular vibrational anharmonicity and vibration-rotation interaction by self-consistent-field higher derivative methods: Applications to asymmetric and symmetric top and linear polyatomic molecules

International Nuclear Information System (INIS)

Clabo, D.A. Jr.

1987-04-01

Inclusion of the anharmonicity normal mode vibrations [i.e., the third and fourth (and higher) derivatives of a molecular Born-Oppenheimer potential energy surface] is necessary in order to theoretically reproduce experimental fundamental vibrational frequencies of a molecule. Although ab initio determinations of harmonic vibrational frequencies may give errors of only a few percent by the inclusion of electron correlation within a large basis set for small molecules, in general, molecular fundamental vibrational frequencies are more often available from high resolution vibration-rotation spectra. Recently developed analytic third derivatives methods for self-consistent-field (SCF) wavefunctions have made it possible to examine with previously unavailable accuracy and computational efficiency the anharmonic force fields of small molecules

Systematic studies of molecular vibrational anharmonicity and vibration-rotation interaction by self-consistent-field higher derivative methods: Applications to asymmetric and symmetric top and linear polyatomic molecules

Energy Technology Data Exchange (ETDEWEB)

Clabo, D.A. Jr.

1987-04-01

Inclusion of the anharmonicity normal mode vibrations (i.e., the third and fourth (and higher) derivatives of a molecular Born-Oppenheimer potential energy surface) is necessary in order to theoretically reproduce experimental fundamental vibrational frequencies of a molecule. Although ab initio determinations of harmonic vibrational frequencies may give errors of only a few percent by the inclusion of electron correlation within a large basis set for small molecules, in general, molecular fundamental vibrational frequencies are more often available from high resolution vibration-rotation spectra. Recently developed analytic third derivatives methods for self-consistent-field (SCF) wavefunctions have made it possible to examine with previously unavailable accuracy and computational efficiency the anharmonic force fields of small molecules.

Higher English for CFE

CERN Document Server

Bridges, Ann; Mitchell, John

2015-01-01

A brand new edition of the former Higher English: Close Reading , completely revised and updated for the new Higher element (Reading for Understanding, Analysis and Evaluation) - worth 30% of marks in the final exam!. We are working with SQA to secure endorsement for this title. Written by two highly experienced authors this book shows you how to practice for the Reading for Understanding, Analysis and Evaluation section of the new Higher English exam. This book introduces the terms and concepts that lie behind success and offers guidance on the interpretation of questions and targeting answer

Higher Education, Employability and Competitiveness

Science.gov (United States)

Pavlin, Samo; Svetlicic, Marjan

2012-01-01

This paper studies the relationship between competitiveness and higher education systems in Europe. It explores whether more competitive countries have developed more labour-market-oriented systems of higher education (HE) that thereby give their graduates greater short term employability potential. Based on and a large-scale survey among 45.000…

Optoelectronic properties of higher acenes, their BN analogue and substituted derivatives

Energy Technology Data Exchange (ETDEWEB)

Armaković, Stevan, E-mail: stevan.armakovic@df.uns.ac.rs [University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovića 4, 21000, Novi Sad (Serbia); Armaković, Sanja J. [University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, 21000, Novi Sad (Serbia); Holodkov, Vladimir [Educons University, Faculty of Sport and Tourism - TIMS, Radnička 30a, 21000, Novi Sad (Serbia); Pelemiš, Svetlana [University of East Sarajevo, Faculty of Technology, Karakaj bb, 75400, Zvornik, Republic of Srpska, Bosnia and Herzegovina (Bosnia and Herzegovina)

2016-02-15

We have investigated optoelectronic properties of higher acenes: pentacene, hexacene, heptacene, octacene, nonacene, decacene and their boron-nitride (BN) analogues, within the framework of density functional theory (DFT). We have also investigated the optoelectronic properties of acenes modified by BN substitution. Calculated optoelectronic properties encompasses: oxidation and reduction potentials, electron and hole reorganization energies and energy difference between excited first singlet and triplet states ΔE(S{sub 1}−T{sub 1}). Oxidation and reduction potentials indicate significantly better stability of BN analogues, comparing with their all-carbon relatives. Although higher acenes possess lower electron and hole reorganization energies, with both best values much lower than 0.1 eV, their BN analogues also have competitive values of reorganization energies, especially for holes for which reorganization energy is also lower than 0.1 eV. On the other hand ΔE(S{sub 1}−T{sub 1}) is much better for BN analogues, having values that indicate that BN analogues are possible applicable for thermally activated delayed fluorescence. - Highlights: • Optoelectronic properties of structures based on higher acenes have been investigated. • Oxidation and reduction potentials together with reorganization energies are calculated. • TADF is analyzed through calculation of ΔE(S{sub 1}−T{sub 1}), which is much better for BN analogues. • Reorganization energies of acenes improve with the increase of number of benzene rings.

INFLUENCE OF THE HIGHER ORDER DERIVATIVES ON THE PLANET PERIHELION PRECESSION IN THE EINSTEIN FIELD EQUATIONS FOR VACUUM CONDITION

Directory of Open Access Journals (Sweden)

Teguh Budi Prayitno

2011-04-01

Full Text Available This paper studies the effect of higher order derivative tensor in the Einstein field equations for vacuum condition on the planet perihelion precession. This tensor was initially proposed as the space-time curvature tensor by Deser and Tekin on discussions about the energy effects caused by this tensor. However, they include this tensor to Einstein field equations as a new model in general relativity theory. This is very interesting since there are some questions in cosmology and astrophysics that have no answers. Thus, they hoped this model could solve those problems by finding analytical or perturbative solution and interpreting it. In this case, the perturbative solution was used to find the Schwarzschild solution and it was also applied to consider the planetary motion in the solar gravitational field. Furthermore, it was proven that the tensor is divergence-free in order to keep the Einstein field equations remain valid.

Higher groupoid bundles, higher spaces, and self-dual tensor field equations

Energy Technology Data Exchange (ETDEWEB)

Jurco, Branislav [Charles University in Prague, Faculty of Mathematics and Physics, Mathematical Institute, Prague (Czech Republic); Saemann, Christian [Maxwell Institute for Mathematical Sciences, Department of Mathematics, Heriot-Watt University, Edinburgh (United Kingdom); Wolf, Martin [Department of Mathematics, University of Surrey, Guildford (United Kingdom)

2016-08-15

We develop a description of higher gauge theory with higher groupoids as gauge structure from first principles. This approach captures ordinary gauge theories and gauged sigma models as well as their categorifications on a very general class of (higher) spaces comprising presentable differentiable stacks, as e.g. orbifolds. We start off with a self-contained review on simplicial sets as models of (∞, 1)-categories. We then discuss principal bundles in terms of simplicial maps and their homotopies. We explain in detail a differentiation procedure, suggested by Severa, that maps higher groupoids to L{sub ∞}-algebroids. Generalising this procedure, we define connections for higher groupoid bundles. As an application, we obtain six-dimensional superconformal field theories via a Penrose-Ward transform of higher groupoid bundles over a twistor space. This construction reduces the search for non-Abelian self-dual tensor field equations in six dimensions to a search for the appropriate (higher) gauge structure. The treatment aims to be accessible to theoretical physicists. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Higher groupoid bundles, higher spaces, and self-dual tensor field equations

International Nuclear Information System (INIS)

Jurco, Branislav; Saemann, Christian; Wolf, Martin

2016-01-01

We develop a description of higher gauge theory with higher groupoids as gauge structure from first principles. This approach captures ordinary gauge theories and gauged sigma models as well as their categorifications on a very general class of (higher) spaces comprising presentable differentiable stacks, as e.g. orbifolds. We start off with a self-contained review on simplicial sets as models of (∞, 1)-categories. We then discuss principal bundles in terms of simplicial maps and their homotopies. We explain in detail a differentiation procedure, suggested by Severa, that maps higher groupoids to L ∞ -algebroids. Generalising this procedure, we define connections for higher groupoid bundles. As an application, we obtain six-dimensional superconformal field theories via a Penrose-Ward transform of higher groupoid bundles over a twistor space. This construction reduces the search for non-Abelian self-dual tensor field equations in six dimensions to a search for the appropriate (higher) gauge structure. The treatment aims to be accessible to theoretical physicists. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Higher order harmonics of reactor neutron equation

International Nuclear Information System (INIS)

Li Fu; Hu Yongming; Luo Zhengpei

1996-01-01

The flux mapping method using the higher order harmonics of the neutron equation is proposed. Based on the bi-orthogonality of the higher order harmonics, the process and formulas for higher order harmonics calculation are derived via the source iteration method with source correction. For the first time, not only any order harmonics for up-to-3-dimensional geometry are achieved, but also the preliminary verification to the capability for flux mapping have been carried out

Emission of massive scalar fields by a higher-dimensional rotating black hole

International Nuclear Information System (INIS)

Kanti, P.; Pappas, N.

2010-01-01

We perform a comprehensive study of the emission of massive scalar fields by a higher-dimensional, simply rotating black hole both in the bulk and on the brane. We derive approximate, analytic results as well as exact numerical ones for the absorption probability, and demonstrate that the two sets agree very well in the low and intermediate-energy regime for scalar fields with mass m Φ ≤1 TeV in the bulk and m Φ ≤0.5 TeV on the brane. The numerical values of the absorption probability are then used to derive the Hawking radiation power emission spectra in terms of the number of extra dimensions, angular-momentum of the black hole and mass of the emitted field. We compute the total emissivities in the bulk and on the brane, and demonstrate that, although the brane channel remains the dominant one, the bulk-over-brane energy ratio is considerably increased (up to 34%) when the mass of the emitted field is taken into account.

Charges in nonlinear higher-spin theory

Energy Technology Data Exchange (ETDEWEB)

Didenko, V.E. [I.E. Tamm Department of Theoretical Physics, Lebedev Physical Institute,Leninsky prospect 53, 119991, Moscow (Russian Federation); Misuna, N.G. [I.E. Tamm Department of Theoretical Physics, Lebedev Physical Institute,Leninsky prospect 53, 119991, Moscow (Russian Federation); Moscow Institute of Physics and Technology,Institutsky lane 9, 141700, Dolgoprudny, Moscow region (Russian Federation); Vasiliev, M.A. [I.E. Tamm Department of Theoretical Physics, Lebedev Physical Institute,Leninsky prospect 53, 119991, Moscow (Russian Federation)

2017-03-30

Nonlinear higher-spin equations in four dimensions admit a closed two-form that defines a gauge-invariant global charge as an integral over a two-dimensional cycle. In this paper we argue that this charge gives rise to partitions depending on various lower- and higher-spin chemical potentials identified with modules of topological fields in the theory. The vacuum contribution to the partition is calculated to the first nontrivial order for a solution to higher-spin equations that generalizes AdS{sub 4} Kerr black hole of General Relativity. The resulting partition is non-zero being in parametric agreement with the ADM-like behavior of a rotating source. The linear response of chemical potentials to the partition function is also extracted. The explicit unfolded form of 4d GR black holes is given. An explicit formula relating asymptotic higher-spin charges expressed in terms of the generalized higher-spin Weyl tensor with those expressed in terms of Fronsdal fields is obtained.

Charges in nonlinear higher-spin theory

International Nuclear Information System (INIS)

Didenko, V.E.; Misuna, N.G.; Vasiliev, M.A.

2017-01-01

Nonlinear higher-spin equations in four dimensions admit a closed two-form that defines a gauge-invariant global charge as an integral over a two-dimensional cycle. In this paper we argue that this charge gives rise to partitions depending on various lower- and higher-spin chemical potentials identified with modules of topological fields in the theory. The vacuum contribution to the partition is calculated to the first nontrivial order for a solution to higher-spin equations that generalizes AdS 4 Kerr black hole of General Relativity. The resulting partition is non-zero being in parametric agreement with the ADM-like behavior of a rotating source. The linear response of chemical potentials to the partition function is also extracted. The explicit unfolded form of 4d GR black holes is given. An explicit formula relating asymptotic higher-spin charges expressed in terms of the generalized higher-spin Weyl tensor with those expressed in terms of Fronsdal fields is obtained.

Response of microbial community of organic-matter-impoverished arable soil to long-term application of soil conditioner derived from dynamic rapid fermentation of food waste.

Science.gov (United States)

Hou, Jiaqi; Li, Mingxiao; Mao, Xuhui; Hao, Yan; Ding, Jie; Liu, Dongming; Xi, Beidou; Liu, Hongliang

2017-01-01

Rapid fermentation of food waste can be used to prepare soil conditioner. This process consumes less time and is more cost-effective than traditional preparation technology. However, the succession of the soil microbial community structure after long-term application of rapid fermentation-derived soil conditioners remains unclear. Herein, dynamic rapid fermentation (DRF) of food waste was performed to develop a soil conditioner and the successions and diversity of bacterial communities in an organic-matter-impoverished arable soil after six years of application of DRF-derived soil conditioner were investigated. Results showed that the treatment increased soil organic matter (SOM) accumulation and strawberry yield by 5.3 g/kg and 555.91 kg/ha, respectively. Proteobacteria, Actinobacteria, Acidobacteria, and Firmicutes became the dominant phyla, occupying 65.95%-77.52% of the bacterial sequences. Principal component analysis (PCA) results showed that the soil bacterial communities were largely influenced by the treatment. Redundancy analysis (RDA) results showed that the relative abundances of Gemmatimonadetes, Chloroflexi, Verrucomicrobia, Nitrospirae, and Firmicutes were significantly correlated with soil TC, TN, TP, NH4+-N, NO3--N, OM, and moisture. These communities were all distributed in the soil samples collected in the sixth year of application. Long-term treatment did not enhance the diversity of bacterial species but significantly altered the distribution of major functional bacterial communities in the soils. Application of DRF-derived soil conditioner could improve the soil quality and optimize the microbial community, ultimately enhancing fruit yields.

Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone

Directory of Open Access Journals (Sweden)

М. R. Fil

2014-12-01

Full Text Available Pyrazole- and aryl-substituted derivatives of 4-thiazolidinone belong to a perspective group of compounds with potential antitumor action. Earlier, we have demonstrated high toxicity in vitro of several 4-thiazolidinones derivatives towards tumor cell lines. To further enhance the antitumor activity of novel 4-thiazolidinones, their chemical scaffold was optimized, and new pyrazole-thiazolidinones were synthesized. That allowed us to combine in one molecule the potential pharmacophore centres of previously tested compounds. As a result, “hybrid” 4-thiazolidinones exhibit higher toxicity in vitro toward tumor cells of various origin. The molecular mechanisms of antineoplastic activity of these compounds and intensity of induction of apoptosis strongly depended on the position of the substituent in the thiazolidinone cycle. In particular, Les-3661 compound, containing pyrazoline fragment in the 4th position of thiazolidinone core, exhibits 14 times higher cytotoxic activity towards tumor cells (LC50 = 3 µM in comparison to its 2-substituted isomer Les-3713 (LC50 = 42 µM. It is demonstrated that in terms of underlying molecular mechanisms for cytotoxic effect the Les-3661 compound induced caspase-8 and caspase-9 dependent mixed-type of apoptosis, while Les-3713 induced apoptosis mediated only by the caspase-8.

Novel Trolox derivatives as antioxidant: A DFT investigation

Directory of Open Access Journals (Sweden)

Farmanzadeh Dvood

2016-01-01

Full Text Available In this paper the antioxidant activity of Trolox derivatives were investigated by density function theory and polarization continuum model as solvent model in order to propose the novel derivatives with higher antioxidant activity from a theoretical viewpoint. The effects of various ortho and meta substituents on the reaction enthalpies of antioxidant mechanisms of Trolox were investigated. Also the effect of reducing the number of atoms in the heterocyclic ring and effect of replacing the oxygen heteroatom of Trolox with other heteroatoms on the antioxidant activity of Trolox were evaluated. Results show that the NH2, OH and NHMe substituents in meta and ortho positions decrease the BDE and IP values and also increase the antioxidant activity of Trolox from the theoretical viewpoint. The derivatives e, c and d with NH, S and Se instead of O have higher antioxidant activity from the theoretical viewpoint. Obtained results show that reducing the number of atom in the heterocyclic ring (derivatives a and b decrease the BDE and IP values and also increase the antioxidant activity of Trolox from the theoretical viewpoint. The linear dependencies between BDE of OH bond and IP values of studied Trolox derivatives and corresponding EHOMO and R(O-H values can be useful to propose novel derivatives with higher antioxidant activity from the theoretical viewpoint.

Assessment and Feedback in Higher Education: A Review of Literature for the Higher Education Academy

Science.gov (United States)

Jackel, Brad; Pearce, Jacob; Radloff, Ali; Edwards, Daniel

2017-01-01

This literature review has been undertaken for the Higher Education Academy (HEA). It explores recent scholarly contributions in the area of assessment and feedback in higher education (HE). As outlined in the HEA's terms of reference for this work, the contents of this review are designed to "help practitioners, policy makers and researchers…

Electro-autotrophic synthesis of higher alcohols

Science.gov (United States)

Liao, James C.; Cho, Kwang Myung

2016-11-01

The disclosure provides a process that converts CO.sub.2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H.sub.2 or formate. H.sub.2 can be derived from electrolysis of water. Formate can be generated by electrochemical reduction of CO.sub.2. After delivering the reducing power in the cell, formate becomes CO.sub.2 and recycles back. Therefore, the biological CO.sub.2 fixation process can occur in the dark.

A new derivation of Dirac's magnetic monopole strength

International Nuclear Information System (INIS)

Panat, P V

2003-01-01

A new derivation of the strength of Dirac's magnetic monopole is presented which does not require an explicit form of the magnetic induction in terms of g, the magnetic pole strength. The derivation essentially uses a modification of Faraday's law of induction and quantization of angular momentum

Higher-order threshold resummation for semi-inclusive e+e- annihilation

International Nuclear Information System (INIS)

Moch, S.; Vogt, A.

2009-08-01

The complete soft-enhanced and virtual-gluon contributions are derived for the quark coefficient functions in semi-inclusive e + e - annihilation to the third order in massless perturbative QCD. These terms enable us to extend the soft-gluon resummation for the fragmentation functions by two orders to the next-to-next-to-next-to-leading logarithmic (N 3 LL) accuracy. The resummation exponent is found to be the same as for the structure functions in inclusive deep-inelastic scattering. This finding, together with known results on the higher-order quark form factor, facilitates the determination of all soft and virtual contributions of the fourth-order difference of the coefficient functions for these two processes. Unlike the previous (N 2 LL) order in the exponentiation, the numerical effect of the N 3 LL contributions turns out to be negligible at LEP energies. (orig.)

Thermodynamics of the Maxwell-Gauss-Bonnet anti-de Sitter black hole with higher derivative gauge corrections

International Nuclear Information System (INIS)

Anninos, Dionysios; Pastras, Georgios

2009-01-01

The local and global thermal phase structure for asymptotically anti-de Sitter black holes charged under an abelian gauge group, with both Gauss-Bonnet and quartic field strength corrections, is mapped out for all parameter space. We work in the grand canonical ensemble where the external electric potential is held fixed. The analysis is performed in an arbitrary number of dimensions, for all three possible horizon topologies - spherical, flat or hyperbolic. For spherical horizons, new metastable configurations are exhibited both for the pure Gauss-Bonnet theory as well as the pure higher derivative gauge theory and combinations thereof. In the pure Gauss-Bonnet theory with negative coefficient and five or more spatial dimensions, two locally thermally stable black hole solutions are found for a given temperature. Either one or both of them may be thermally favored over the anti-de Sitter vacuum - corresponding to a single or a double decay channel for the metastable black hole. Similar metastable configurations are uncovered for the theory with pure quartic field strength corrections, as well combinations of the two types of corrections, in three or more spatial dimensions. Finally, a secondary Hawking-Page transition between the smaller thermally favored black hole and thermal anti-de Sitter space is observed when both corrections are turned on and their couplings are both positive.

On the quantum dynamical foundations of collision terms

International Nuclear Information System (INIS)

Nemes, M.C.; Toledo Piza, A.F.R. de

1981-08-01

Collision terms are non-unitary corrections usually added to mean field descriptions in order to describe dissipative effects. Derivations of collision terms usually include assumptions which lack an explicit connection with a fully quantum dynamical description. Quantum dynamical foundations of collision terms are examined: they are shown to reflect the dynamics of quantum correlations. A careful study of the non-unitary aspects of the evolution of quantum correlations leads naturally to an unambiguous definition of a collision term. This collision term is shown to obey a non-linear pre-master equation, whose derivation is fully quantum-mechanical. Moreover, it is shown that quantum correlations also yield an unitary correction to the mean field description, which could be absorbed in a suitable redefinition of the mean field. Formal expressions for these corrections are derived and their connection with memory effects exhibited explicitely. The typical time of evaluation of quantum correlations allows for an analytical expression for the 'lifetime of mean field descriptions'. Finally, a quantum mechanical point of view for 'irreversibility' in deep inelastic is discussed. (Author) [pt

Estimation of rumen microbial-nitrogen of sheep using urinary excretion of purine derivatives

International Nuclear Information System (INIS)

Liu Dasen; Shan Anshan

2004-01-01

Determination of rumen microbial-nitrogen of sheep using urinary excretion of purine derivative was studied. Uric acid and xanthine + hypoxanthine were not affected by diets, but total purine derivatives for 1 mg borax/kg diet was higher than other diets (p<0.05). Microbial-nitrogen estimated from allantoin was not affected by diets, but that of 1 mg borax/kg diet estimated from total purine derivatives was higher than other diets (p<0.05). Microbial-nitrogen estimated from total purine derivatives was higher than that from allantoin

Thermodynamics of higher spin black holes in AdS3

International Nuclear Information System (INIS)

Boer, Jan de; Jottar, Juan I.

2014-01-01

We discuss the thermodynamics of recently constructed three-dimensional higher spin black holes in SL(N,ℝ)×SL(N,ℝ) Chern-Simons theory with generalized asymptotically-anti-de Sitter boundary conditions. From a holographic perspective, these bulk theories are dual to two-dimensional CFTs with W N symmetry algebras, and the black hole solutions are dual to thermal states with higher spin chemical potentials and charges turned on. Because the notion of horizon area is not gauge-invariant in the higher spin theory, the traditional approaches to the computation of black hole entropy must be reconsidered. One possibility, explored in the recent literature, involves demanding the existence of a partition function in the CFT, and consistency with the first law of thermodynamics. This approach is not free from ambiguities, however, and in particular different definitions of energy result in different expressions for the entropy. In the present work we show that there are natural definitions of the thermodynamically conjugate variables that follow from careful examination of the variational principle, and moreover agree with those obtained via canonical methods. Building on this intuition, we derive general expressions for the higher spin black hole entropy and free energy which are written entirely in terms of the Chern-Simons connections, and are valid for both static and rotating solutions. We compare our results to other proposals in the literature, and provide a new and efficient way to determine the generalization of the Cardy formula to a situation with higher spin charges

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin− HSCs

International Nuclear Information System (INIS)

Toyama, Hirofumi; Arai, Fumio; Hosokawa, Kentaro; Ikushima, Yoshiko Matsumoto; Suda, Toshio

2012-01-01

Highlights: ► High N-cad expression was detected in E12.5 mouse FL LT-HSCs (EPCR + LSK cells). ► Immunohistochemically, N-cad + HSCs co-localized with sinusoidal ECs (Lyve-1 + cells) in E12.5 FL, but these gradually detached in E15.5 and E18.5 FL. ► N-cad + LSK cells in E12.5 FL exhibited higher LTR activity versus N-cad − LSK cells, which decreased in E15.5 and E18.5. ► N-cad expression may confer high LTR activity to HSCs by facilitating interactions with the perisinusoidal niche in FL. -- Abstract: Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment known as the stem cell niche. The regulation of HSCs in fetal liver (FL) and their niche, however, remains to be elucidated. In this study, we investigated the role of N-cadherin (N-cad) in the maintenance of HSCs during FL hematopoiesis. By using anti-N-cad antibodies (Abs) produced by our laboratory, we detected high N-cad expression in embryonic day 12.5 (E12.5) mouse FL HSCs, but not in E15.5 and E18.5 FL. Immunofluorescence staining revealed that N-cad + c-Kit + and N-cad + endothelial protein C receptor (EPCR) + HSCs co-localized with Lyve-1 + sinusoidal endothelial cells (ECs) in E12.5 FL and that some of these cells also expressed N-cad. However, N-cad + HSCs were also observed to detach from the perisinusoidal niche at E15.5 and E18.5, concomitant with a down-regulation of N-cad and an up-regulation of E-cadherin (E-cad) in hepatic cells. Moreover, EPCR + long-term (LT)-HSCs were enriched in the N-cad + Lin − Sca-1 + c-Kit + (LSK) fraction in E12.5 FL, but not in E15.5 or E18.5 FL. In a long-term reconstitution (LTR) activity assay, higher engraftment associated with N-cad + LSK cells versus N-cad − LSK cells in E12.5 FL when transplanted into lethally irradiated recipient mice. However, the higher engraftment of N-cad + LSK cells decreased subsequently in E15.5 and E18.5 FL. It is possible that N-cad expression conferred higher LTR activity to HSCs by facilitating

Generalized Fractional Derivative Anisotropic Viscoelastic Characterization

Directory of Open Access Journals (Sweden)

Harry H. Hilton

2012-01-01

Full Text Available Isotropic linear and nonlinear fractional derivative constitutive relations are formulated and examined in terms of many parameter generalized Kelvin models and are analytically extended to cover general anisotropic homogeneous or non-homogeneous as well as functionally graded viscoelastic material behavior. Equivalent integral constitutive relations, which are computationally more powerful, are derived from fractional differential ones and the associated anisotropic temperature-moisture-degree-of-cure shift functions and reduced times are established. Approximate Fourier transform inversions for fractional derivative relations are formulated and their accuracy is evaluated. The efficacy of integer and fractional derivative constitutive relations is compared and the preferential use of either characterization in analyzing isotropic and anisotropic real materials must be examined on a case-by-case basis. Approximate protocols for curve fitting analytical fractional derivative results to experimental data are formulated and evaluated.

Ward identities of W{sub {infinity}} symmetry and higher-genus amplitudes in 2D string theory

Energy Technology Data Exchange (ETDEWEB)

Hamada, K. [National Lab. for High Energy Physics, Ibaraki (Japan)

1996-03-04

The Ward identities of the W{sub {infinity}} symmetry in two-dimensional string theory in the tachyon background are studied in the continuum approach. We consider amplitudes different from 2D string ones by the external leg factor and derive the recursion relations among them. The recursion relations have non-linear terms which give relations among the amplitudes defined on different genus. The solutions agree with the matrix model results even in higher genus. We also discuss the differences of the roles of the external leg factor between the c{sub M} = 1 model and the c{sub M} <1 model. (orig.).

Single-shot imaging with higher-dimensional encoding using magnetic field monitoring and concomitant field correction.

Science.gov (United States)

Testud, Frederik; Gallichan, Daniel; Layton, Kelvin J; Barmet, Christoph; Welz, Anna M; Dewdney, Andrew; Cocosco, Chris A; Pruessmann, Klaas P; Hennig, Jürgen; Zaitsev, Maxim

2015-03-01

PatLoc (Parallel Imaging Technique using Localized Gradients) accelerates imaging and introduces a resolution variation across the field-of-view. Higher-dimensional encoding employs more spatial encoding magnetic fields (SEMs) than the corresponding image dimensionality requires, e.g. by applying two quadratic and two linear spatial encoding magnetic fields to reconstruct a 2D image. Images acquired with higher-dimensional single-shot trajectories can exhibit strong artifacts and geometric distortions. In this work, the source of these artifacts is analyzed and a reliable correction strategy is derived. A dynamic field camera was built for encoding field calibration. Concomitant fields of linear and nonlinear spatial encoding magnetic fields were analyzed. A combined basis consisting of spherical harmonics and concomitant terms was proposed and used for encoding field calibration and image reconstruction. A good agreement between the analytical solution for the concomitant fields and the magnetic field simulations of the custom-built PatLoc SEM coil was observed. Substantial image quality improvements were obtained using a dynamic field camera for encoding field calibration combined with the proposed combined basis. The importance of trajectory calibration for single-shot higher-dimensional encoding is demonstrated using the combined basis including spherical harmonics and concomitant terms, which treats the concomitant fields as an integral part of the encoding. © 2014 Wiley Periodicals, Inc.

TRIXcell+, a new long-term boar semen extender containing whey protein with higher preservation capacity and litter size

Directory of Open Access Journals (Sweden)

B.M. van den Berg

2014-02-01

Full Text Available It was the aim of the present study to test whey as protective protein for the sperm cell in the long-term boar semen preservation medium TRIXcell. Analyses of sperm cell motility using computer-assisted semen analysis (CASA indicated that the whey protein Porex has a similar protective effect as bovine serum albumin (BSA in maintaining viability of stored boar sperm. Boar sperm diluted in TRIXcell+ maintains commercially acceptable motility (>60% for 10 days, while swine sperm diluted in the semen preservation medium Beltsville Thawing Solution (BTS maintains commercially acceptable motility (>60% for 3-5 days for most boars. To test the on-farm fertility performance of TRIXcell+ compared to BTS, inseminations were started on 35 commercial pig production farms in the summer of 2006. During the period of July 2006 until July 2012 for each farm and each calendar year the mean farrowing rate and litter size for semen diluted in TRIXcell+ and stored for 3-5 days was found higher than that of semen stored for 1-2 days in BTS. Based on data gained from a total of 583.749 sows inseminated through the years 2006-2012, the mean farrowing rate for semen diluted in TRIXcell+ and BTS was 90.4 ± 4.0 and 87.9 ± 3.6, respectively, which is not significantly different. Based on the same data, the mean total number of piglets born alive for semen diluted in TRIXcell+ and BTS was 14.2 ± 0.7 and 13.6 ± 0.6, respectively, which is significantly different. We conclude that whey protein can effectively be used in the long-term preservation medium TRIXcell resulting in a higher litter size.

TRIXcell+, a new long-term boar semen extender containing whey protein with higher preservation capacity and litter size

Science.gov (United States)

van den Berg, B.M.; Reesink, J.; Reesink, W.

2014-01-01

It was the aim of the present study to test whey as protective protein for the sperm cell in the long-term boar semen preservation medium TRIXcell. Analyses of sperm cell motility using computer-assisted semen analysis (CASA) indicated that the whey protein Porex has a similar protective effect as bovine serum albumin (BSA) in maintaining viability of stored boar sperm. Boar sperm diluted in TRIXcell+ maintains commercially acceptable motility (>60%) for 10 days, while swine sperm diluted in the semen preservation medium Beltsville Thawing Solution (BTS) maintains commercially acceptable motility (>60%) for 3-5 days for most boars. To test the on-farm fertility performance of TRIXcell+ compared to BTS, inseminations were started on 35 commercial pig production farms in the summer of 2006. During the period of July 2006 until July 2012 for each farm and each calendar year the mean farrowing rate and litter size for semen diluted in TRIXcell+ and stored for 3-5 days was found higher than that of semen stored for 1-2 days in BTS. Based on data gained from a total of 583.749 sows inseminated through the years 2006-2012, the mean farrowing rate for semen diluted in TRIXcell+ and BTS was 90.4 ± 4.0 and 87.9 ± 3.6, respectively, which is not significantly different. Based on the same data, the mean total number of piglets born alive for semen diluted in TRIXcell+ and BTS was 14.2 ± 0.7 and 13.6 ± 0.6, respectively, which is significantly different. We conclude that whey protein can effectively be used in the long-term preservation medium TRIXcell resulting in a higher litter size. PMID:26623335

Holographic entanglement for Chern-Simons terms

International Nuclear Information System (INIS)

Azeyanagi, Tatsuo; Loganayagam, R.; Ng, Gim Seng

2017-01-01

We derive the holographic entanglement entropy contribution from pure and mixed gravitational Chern-Simons(CS) terms in AdS 2k+1 . This is done through two different methods: first, by a direct evaluation of CS action in a holographic replica geometry and second by a descent of Dong’s derivation applied to the corresponding anomaly polynomial. In lower dimensions (k=1,2), the formula coincides with the Tachikawa formula for black hole entropy from gravitational CS terms. New extrinsic curvature corrections appear for k≥3: we give explicit and concise expressions for the two pure gravitational CS terms in AdS 7 and present various consistency checks, including agreements with the black hole entropy formula when evaluated at the bifurcation surface.

Holographic entanglement for Chern-Simons terms

Energy Technology Data Exchange (ETDEWEB)

Azeyanagi, Tatsuo [Département de Physique, Ecole Normale Supérieure, CNRS,24 rue Lhomond, 75005 Paris (France); Loganayagam, R. [School of Natural Sciences, Institute for Advanced Study,Princeton, NJ 08540 (United States); Ng, Gim Seng [Department of Physics, McGill University,Montréal, QC H3A 2T8 (Canada)

2017-02-01

We derive the holographic entanglement entropy contribution from pure and mixed gravitational Chern-Simons(CS) terms in AdS{sub 2k+1}. This is done through two different methods: first, by a direct evaluation of CS action in a holographic replica geometry and second by a descent of Dong’s derivation applied to the corresponding anomaly polynomial. In lower dimensions (k=1,2), the formula coincides with the Tachikawa formula for black hole entropy from gravitational CS terms. New extrinsic curvature corrections appear for k≥3: we give explicit and concise expressions for the two pure gravitational CS terms in AdS{sub 7} and present various consistency checks, including agreements with the black hole entropy formula when evaluated at the bifurcation surface.

Holographic entanglement for Chern-Simons terms

Science.gov (United States)

Azeyanagi, Tatsuo; Loganayagam, R.; Ng, Gim Seng

2017-02-01

We derive the holographic entanglement entropy contribution from pure and mixed gravitational Chern-Simons(CS) terms in AdS2 k+1. This is done through two different methods: first, by a direct evaluation of CS action in a holographic replica geometry and second by a descent of Dong's derivation applied to the corresponding anomaly polynomial. In lower dimensions ( k = 1 , 2), the formula coincides with the Tachikawa formula for black hole entropy from gravitational CS terms. New extrinsic curvature corrections appear for k ≥ 3: we give explicit and concise expressions for the two pure gravitational CS terms in AdS7 and present various consistency checks, including agreements with the black hole entropy formula when evaluated at the bifurcation surface.

Sulfur flow in a soil-plant system-effects of long-term treatment history and soil properties

DEFF Research Database (Denmark)

Boye, Kristin; Eriksen, Jørgen; Nilsson, Ingvar

2010-01-01

deficiency, reduced biomass production and lower total S uptake by the rye grass. The isotopic measurements revealed that more than two thirds of the plant S was derived from non-labeled soil organic S, even in the + S treatment, and that all organic S pools (physically unprotected/protected and residual...... organic S) in the soil were involved in the S transformations. The long-term FYM treatment had resulted in higher S cycling rates and a slightly higher resistance to S deficiency than the CR treatment. The influence of soil type on S flow patterns was important, but probably only partly related...

Customer Prioritization in Higher Education: Targeting "Right" Students for Long-Term Profitability

Science.gov (United States)

Harrison-Walker, L. Jean

2010-01-01

As competition for students, faculty and financial support has increased, so has the application of marketing in the field of higher education. One critical application of marketing all too often neglected, misunderstood and mismanaged in higher education is targeting customers for profitability. The purpose of this paper is to enrich the…

Neural classifiers for learning higher-order correlations

International Nuclear Information System (INIS)

Gueler, M.

1999-01-01

Studies by various authors suggest that higher-order networks can be more powerful and biologically more plausible with respect to the more traditional multilayer networks. These architecture make explicit use of nonlinear interactions between input variables in the form of higher-order units or product units. If it is known a priori that the problem to be implemented possesses a given set of invariances like in the translation, rotation, and scale invariant recognition problems, those invariances can be encoded, thus eliminating all higher-order terms which are incompatible with the invariances. In general, however, it is a serious set-back that the complexity of learning increases exponentially with the size of inputs. This paper reviews higher-order networks and introduces an implicit representation in which learning complexity is mainly decided by the number of higher-order terms to be learned and increases only linearly with the input size

Neural Classifiers for Learning Higher-Order Correlations

Science.gov (United States)

Güler, Marifi

1999-01-01

Studies by various authors suggest that higher-order networks can be more powerful and are biologically more plausible with respect to the more traditional multilayer networks. These architectures make explicit use of nonlinear interactions between input variables in the form of higher-order units or product units. If it is known a priori that the problem to be implemented possesses a given set of invariances like in the translation, rotation, and scale invariant pattern recognition problems, those invariances can be encoded, thus eliminating all higher-order terms which are incompatible with the invariances. In general, however, it is a serious set-back that the complexity of learning increases exponentially with the size of inputs. This paper reviews higher-order networks and introduces an implicit representation in which learning complexity is mainly decided by the number of higher-order terms to be learned and increases only linearly with the input size.

Differences between the genomes of lymphoblastoid cell lines and blood-derived samples

Directory of Open Access Journals (Sweden)

Joesch-Cohen LM

2017-02-01

Full Text Available Lena M Joesch-Cohen, Gustavo Glusman Institute for Systems Biology, Seattle, WA, USA Abstract: Lymphoblastoid cell lines (LCLs represent a convenient research tool for expanding the amount of biologic material available from an individual. LCLs are commonly used as reference materials, most notably from the Genome in a Bottle Consortium. However, the question remains how faithfully LCL-derived genome assemblies represent the germline genome of the donor individual as compared to the genome assemblies derived from peripheral blood mononuclear cells. We present an in-depth comparison of a large collection of LCL- and peripheral blood mononuclear cell-derived genomes in terms of distributions of coverage and copy number alterations. We found significant differences in the depth of coverage and copy number calls, which may be driven by differential replication timing. Importantly, these copy number changes preferentially affect regions closer to genes and with higher GC content. This suggests that genomic studies based on LCLs may display locus-specific biases, and that conclusions based on analysis of depth of coverage and copy number variation may require further scrutiny. Keywords: genomics, whole-genome sequencing, viral transformation, copy number changes, bioinformatics

Functional-derivative study of the Hubbard model. III. Fully renormalized Green's function

International Nuclear Information System (INIS)

Arai, T.; Cohen, M.H.

1980-01-01

The functional-derivative method of calculating the Green's function developed earlier for the Hubbard model is generalized and used to obtain a fully renormalized solution. Higher-order functional derivatives operating on the basic Green's functions, G and GAMMA, are all evaluated explicitly, thus making the solution applicable to the narrow-band region as well as the wide-band region. Correction terms Phi generated from functional derivatives of equal-time Green's functions of the type delta/sup n/ /deltaepsilon/sup n/, etc., with n > or = 2. It is found that the Phi's are, in fact, renormalization factors involved in the self-energy Σ and that the structure of the Phi's resembles that of Σ and contains the same renormalization factors Phi. The renormalization factors Phi are shown to satisfy a set of equations and can be evaluated self-consistently. In the presence of the Phi's, all difficulties found in the previous results (papers I and II) are removed, and the energy spectrum ω can now be evaluated for all occupations n. The Schwinger relation is the only basic relation used in generating this fully self-consistent Green's function, and the Baym-Kadanoff continuity condition is automatically satisfied

Translational applications of adult stem cell-derived organoids

NARCIS (Netherlands)

Drost, Jarno; Clevers, Hans

2017-01-01

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from

Higher Order Expectations in Asset Pricing

OpenAIRE

Philippe BACCHETTA; Eric VAN WINCOOP

2004-01-01

We examine formally Keynes' idea that higher order beliefs can drive a wedge between an asset price and its fundamental value based on expected future payoffs. Higher order expectations add an additional term to a standard asset pricing equation. We call this the higher order wedge, which depends on the difference between higher and first order expectations of future payoffs. We analyze the determinants of this wedge and its impact on the equilibrium price. In the context of a dynamic noisy r...

Multiscale analysis of the CMB temperature derivatives

Energy Technology Data Exchange (ETDEWEB)

Marcos-Caballero, A.; Martínez-González, E.; Vielva, P., E-mail: marcos@ifca.unican.es, E-mail: martinez@ifca.unican.es, E-mail: vielva@ifca.unican.es [Instituto de Física de Cantabria, CSIC-Universidad de Cantabria, Avda. de los Castros s/n, 39005 Santander, Spain. (Spain)

2017-02-01

We study the Planck CMB temperature at different scales through its derivatives up to second order, which allows one to characterize the local shape and isotropy of the field. The problem of having an incomplete sky in the calculation and statistical characterization of the derivatives is addressed in the paper. The analysis confirms the existence of a low variance in the CMB at large scales, which is also noticeable in the derivatives. Moreover, deviations from the standard model in the gradient, curvature and the eccentricity tensor are studied in terms of extreme values on the data. As it is expected, the Cold Spot is detected as one of the most prominent peaks in terms of curvature, but additionally, when the information of the temperature and its Laplacian are combined, another feature with similar probability at the scale of 10{sup o} is also observed. However, the p -value of these two deviations increase above the 6% when they are referred to the variance calculated from the theoretical fiducial model, indicating that these deviations can be associated to the low variance anomaly. Finally, an estimator of the directional anisotropy for spinorial quantities is introduced, which is applied to the spinors derived from the field derivatives. An anisotropic direction whose probability is <1% is detected in the eccentricity tensor.

Higher exercise intensity delays postexercise recovery of impedance-derived cardiac sympathetic activity.

Science.gov (United States)

Michael, Scott; Jay, Ollie; Graham, Kenneth S; Davis, Glen M

2017-08-01

Systolic time intervals (STIs) provide noninvasive insights into cardiac sympathetic neural activity (cSNA). As the effect of exercise intensity on postexercise STI recovery is unclear, this study investigated the STI recovery profile after different exercise intensities. Eleven healthy males cycled for 8 min at 3 separate intensities: LOW (40%-45%), MOD (75%-80%), and HIGH (90%-95%) of heart-rate (HR) reserve. Bio-impedance cardiography was used to assess STIs - primarily pre-ejection period (PEP; inversely correlated with cSNA), as well as left ventricular ejection time (LVET) and PEP:LVET - during 10 min seated recovery immediately postexercise. Heart-rate variability (HRV), i.e., natural-logarithm of root mean square of successive differences (Ln-RMSSD), was calculated as an index of cardiac parasympathetic neural activity (cPNA). Higher preceding exercise intensity elicited a slower recovery of HR and Ln-RMSSD (p return to baseline by 10 min following any intensity (p ≤ 0.009). Recovery of STIs was also slower following higher intensity exercise (p ≤ 0.002). By 30 s postexercise, higher preceding intensity resulted in a lower PEP (98 ± 14 ms, 75 ± 6 ms, 66 ± 5 ms for LOW, MOD, and HIGH, respectively, p fashion. While exercise intensity must be considered, acute recovery may be a valuable period during which to concurrently monitor these noninvasive indices, to identify potentially abnormal cardiac autonomic responses.

Derivative-Based Trapezoid Rule for the Riemann-Stieltjes Integral

Directory of Open Access Journals (Sweden)

Weijing Zhao

2014-01-01

Full Text Available The derivative-based trapezoid rule for the Riemann-Stieltjes integral is presented which uses 2 derivative values at the endpoints. This kind of quadrature rule obtains an increase of two orders of precision over the trapezoid rule for the Riemann-Stieltjes integral and the error term is investigated. At last, the rationality of the generalization of derivative-based trapezoid rule for Riemann-Stieltjes integral is demonstrated.

An alternative to the flutter derivatives

DEFF Research Database (Denmark)

Andersen, Michael Styrk; Brandt, Anders

A new simplified framework to study flutter and assess the full scale flutter wind speed is suggested. The flutter instability problem is reduced from a problem involving 8 flutter derivatives to only 4 coefficients. With this method it is possible to estimate the self-excited forces with increased...... precision by using stability diagrams. Furthermore, the physical transparency of the aerodynamic damping and stiffness terms is increased because the development in vertical and torsional damping and stiffness is analysed instead of flutter derivatives....

Higher-twist correlations in polarized hadrons

International Nuclear Information System (INIS)

Tangerman, R.D.

1996-01-01

In this thesis we studied the response of polarized hadrons to several high-energy probes, working in the framework of the field theoretic model. Emphasis is laid upon higher-twist effects such as quark transverse momentum. The inclusive DIS process is very well suited to study QCD. From general principles we were able to derive four positivity constraints on the structure functions without invoking the helicity formalism. The on-shell quark model is used to illustrate these constraints. Subseqeuently, we concentrated on the higher-twist structure function g 2 (x,Q 2 ). (orig./HSI)

The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

NARCIS (Netherlands)

Hajmousa, Ghazaleh; Vogelaar, Pieter; Brouwer, Linda A.; Graaf, Adrianus Cornelis van der; Henning, Robert H.; Krenning, Guido

Encouraging advances in cell therapy research with adipose derived stem cells (ASC) require an effective short-term preservation method that provides time for quality control and transport of cells from their manufacturing facility to their clinical destination. Hypothermic storage of cells in their

Separation of [Rh-103m]-rhodocene-derivatives from the parent [103Ru]ruthenocen-derivatives and their organ distribution

International Nuclear Information System (INIS)

Wenzel, M.; Wu, Y.

1987-01-01

The radioactive decay of [ 103 Ru]ruthenocene derivatives leads to sup(103m)Rh labelled rhodocinium derivatives, which can be separated by the extraction of a lipophilic solution of the ruthenocen derivate with water. The separation factor sup(103m)Rh/ 103 Ru reaches values of 32:1 Rh 3+ ions are not liberated and extracted. The organ distribution of the sup(103m)Rh labelled rhodocinium derivatives gained from ruthenocene and from N-isopropyl-ruthenocene amphetamine is different from the distribution of the parent ruthenocene compound. The liver and kidney uptake of the rhodocinium-amphetamine is much higher than the uptake with ruthenocene amphetamine. (author)

Who Is Missing from Higher Education?

Science.gov (United States)

Gorard, Stephen

2008-01-01

This paper discusses the difficulties of establishing a clear count of UK higher education students in terms of the categories used for widening participation, such as occupational background or ethnicity. Using some of the best and most complete data available, such as the annual figures from the Higher Education Statistics Agency, the paper then…

Covariant quantization of infinite spin particle models, and higher order gauge theories

International Nuclear Information System (INIS)

Edgren, Ludde; Marnelius, Robert

2006-01-01

Further properties of a recently proposed higher order infinite spin particle model are derived. Infinitely many classically equivalent but different Hamiltonian formulations are shown to exist. This leads to a condition of uniqueness in the quantization process. A consistent covariant quantization is shown to exist. Also a recently proposed supersymmetric version for half-odd integer spins is quantized. A general algorithm to derive gauge invariances of higher order Lagrangians is given and applied to the infinite spin particle model, and to a new higher order model for a spinning particle which is proposed here, as well as to a previously given higher order rigid particle model. The latter two models are also covariantly quantized

Distributed order reaction-diffusion systems associated with Caputo derivatives

Science.gov (United States)

Saxena, R. K.; Mathai, A. M.; Haubold, H. J.

2014-08-01

This paper deals with the investigation of the solution of an unified fractional reaction-diffusion equation of distributed order associated with the Caputo derivatives as the time-derivative and Riesz-Feller fractional derivative as the space-derivative. The solution is derived by the application of the joint Laplace and Fourier transforms in compact and closed form in terms of the H-function. The results derived are of general nature and include the results investigated earlier by other authors, notably by Mainardi et al. ["The fundamental solution of the space-time fractional diffusion equation," Fractional Calculus Appl. Anal. 4, 153-202 (2001); Mainardi et al. "Fox H-functions in fractional diffusion," J. Comput. Appl. Math. 178, 321-331 (2005)] for the fundamental solution of the space-time fractional equation, including Haubold et al. ["Solutions of reaction-diffusion equations in terms of the H-function," Bull. Astron. Soc. India 35, 681-689 (2007)] and Saxena et al. ["Fractional reaction-diffusion equations," Astrophys. Space Sci. 305, 289-296 (2006a)] for fractional reaction-diffusion equations. The advantage of using the Riesz-Feller derivative lies in the fact that the solution of the fractional reaction-diffusion equation, containing this derivative, includes the fundamental solution for space-time fractional diffusion, which itself is a generalization of fractional diffusion, space-time fraction diffusion, and time-fractional diffusion, see Schneider and Wyss ["Fractional diffusion and wave equations," J. Math. Phys. 30, 134-144 (1989)]. These specialized types of diffusion can be interpreted as spatial probability density functions evolving in time and are expressible in terms of the H-function in compact forms. The convergence conditions for the double series occurring in the solutions are investigated. It is interesting to observe that the double series comes out to be a special case of the Srivastava-Daoust hypergeometric function of two variables

Radion stabilization in higher curvature warped spacetime

Energy Technology Data Exchange (ETDEWEB)

Das, Ashmita [Indian Institute of Technology, Department of Physics, Guwahati, Assam (India); Mukherjee, Hiya; Paul, Tanmoy; SenGupta, Soumitra [Indian Association for the Cultivation of Science, Department of Theoretical Physics, Kolkata (India)

2018-02-15

We consider a five dimensional AdS spacetime in presence of higher curvature term like F(R) = R + αR{sup 2} in the bulk. In this model, we examine the possibility of modulus stabilization from the scalar degrees of freedom of higher curvature gravity free of ghosts. Our result reveals that the model stabilizes itself and the mechanism of modulus stabilization can be argued from a geometric point of view. We determine the region of the parametric space for which the modulus (or radion) can to be stabilized. We also show how the mass and coupling parameters of radion field are modified due to higher curvature term leading to modifications of its phenomenological implications on the visible 3-brane. (orig.)

Open-Source Assisted Laboratory Automation through Graphical User Interfaces and 3D Printers: Application to Equipment Hyphenation for Higher-Order Data Generation.

Science.gov (United States)

Siano, Gabriel G; Montemurro, Milagros; Alcaráz, Mirta R; Goicoechea, Héctor C

2017-10-17

Higher-order data generation implies some automation challenges, which are mainly related to the hidden programming languages and electronic details of the equipment. When techniques and/or equipment hyphenation are the key to obtaining higher-order data, the required simultaneous control of them demands funds for new hardware, software, and licenses, in addition to very skilled operators. In this work, we present Design of Inputs-Outputs with Sikuli (DIOS), a free and open-source code program that provides a general framework for the design of automated experimental procedures without prior knowledge of programming or electronics. Basically, instruments and devices are considered as nodes in a network, and every node is associated both with physical and virtual inputs and outputs. Virtual components, such as graphical user interfaces (GUIs) of equipment, are handled by means of image recognition tools provided by Sikuli scripting language, while handling of their physical counterparts is achieved using an adapted open-source three-dimensional (3D) printer. Two previously reported experiments of our research group, related to fluorescence matrices derived from kinetics and high-performance liquid chromatography, were adapted to be carried out in a more automated fashion. Satisfactory results, in terms of analytical performance, were obtained. Similarly, advantages derived from open-source tools assistance could be appreciated, mainly in terms of lesser intervention of operators and cost savings.

Word Origins of Common Neuroscience Terms for Use in an Undergraduate Classroom.

Science.gov (United States)

Hallock, Robert M; Brand, Emma C; Mihalic, Taylor B

2016-01-01

We compiled a list of nearly 300 neuroscience terms and list their language of origin (typically Latin or Greek), their literal meaning, and their pronunciation in a table. The table was distributed to students in an undergraduate neuroscience class a few weeks before the first examination. A follow-up survey asked students how long they spent with the handout, and also assessed whether they thought it helped them better understand the terms, apply the terms, and whether they thought it helped them enough to get a higher grade on the exam. Results were positive: nearly 78% of students used the table while reviewing the material, and these students overwhelmingly reported that the table helped them better understand and apply the terms. However, students were equally split on whether the handout resulted in a better grade on the first exam. It was our premise that better understanding the derivation of the words can help students make associations between the terms and their meanings/functions. This handout can be used in any undergraduate neuroscience to help students better understand the complex terminology associated with the material.

Patient-Specific Seizure Detection in Long-Term EEG Using Signal-Derived Empirical Mode Decomposition (EMD)-based Dictionary Approach.

Science.gov (United States)

Kaleem, Muhammad; Gurve, Dharmendra; Guergachi, Aziz; Krishnan, Sridhar

2018-06-25

The objective of the work described in this paper is development of a computationally efficient methodology for patient-specific automatic seizure detection in long-term multi-channel EEG recordings. Approach: A novel patient-specific seizure detection approach based on signal-derived Empirical Mode Decomposition (EMD)-based dictionary approach is proposed. For this purpose, we use an empirical framework for EMD-based dictionary creation and learning, inspired by traditional dictionary learning methods, in which the EMD-based dictionary is learned from the multi-channel EEG data being analyzed for automatic seizure detection. We present the algorithm for dictionary creation and learning, whose purpose is to learn dictionaries with a small number of atoms. Using training signals belonging to seizure and non-seizure classes, an initial dictionary, termed as the raw dictionary, is formed. The atoms of the raw dictionary are composed of intrinsic mode functions obtained after decomposition of the training signals using the empirical mode decomposition algorithm. The raw dictionary is then trained using a learning algorithm, resulting in a substantial decrease in the number of atoms in the trained dictionary. The trained dictionary is then used for automatic seizure detection, such that coefficients of orthogonal projections of test signals against the trained dictionary form the features used for classification of test signals into seizure and non-seizure classes. Thus no hand-engineered features have to be extracted from the data as in traditional seizure detection approaches. Main results: The performance of the proposed approach is validated using the CHB-MIT benchmark database, and averaged accuracy, sensitivity and specificity values of 92.9%, 94.3% and 91.5%, respectively, are obtained using support vector machine classifier and five-fold cross-validation method. These results are compared with other approaches using the same database, and the suitability

Higher order spin-dependent terms in D0-brane scattering from the matrix model

International Nuclear Information System (INIS)

McArthur, I.N.

1998-01-01

The potential describing long-range interactions between D0-branes contains spin-dependent terms. In the matrix model, these should be reproduced by the one-loop effective action computed in the presence of a non-trivial fermionic background ψ. The v 3 ψ 2 /r 8 term in the effective action has been computed by Kraus and shown to correspond to a spin-orbit interaction between D0-branes, and the ψ 8 /r 11 term in the static potential has been obtained by Barrio et al. In this paper, the v 2 ψ 4 /r 9 term is computing in the matrix model and compared with the corresponding results of Morales et al. obtained using string theoretic methods. The technique employed is adapted to the underlying supersymmetry of the matrix model, and should be useful in the calculation of spin-dependent effects in more general Dp-brane scatterings. (orig.)

Derivative financial instruments and nonprofit health care providers.

Science.gov (United States)

Stewart, Louis J; Owhoso, Vincent

2004-01-01

This article examines the extent of derivative financial instrument use among US nonprofit health systems and the impact of these financial instruments on their cash flows, reported operating results, and financial risks. Our examination is conducted through a case study of New Jersey hospitals and health systems. We review the existing literature on interest rate derivative instruments and US hospitals and health systems. This literature describes the design of these derivative financial instruments and the theoretical benefits of their use by large health care provider organizations. Our contribution to the literature is to provide an empirical evaluation of derivative financial instruments usage among a geographically limited sample of US nonprofit health systems. We reviewed the audited financial statements of the 49 community hospitals and multi-hospital health systems operating in the state of New Jersey. We found that 8 percent of New Jersey's nonprofit health providers utilized interest rate derivatives with an aggregate principle value of $229 million. These derivative users combine interest rate swaps and caps to lower the effective interest costs of their long-term debt while limiting their exposure to future interest rate increases. In addition, while derivative assets and liabilities have an immaterial balance sheet impact, derivative related gains and losses are a material component of their reported operating results. We also found that derivative usage among these four health systems was responsible for generating positive cash flows in the range of 1 percent to 2 percent of their total 2001 cash flows from operations. As a result of our admittedly limited samples we conclude that interest rate swaps and caps are effective risk management tools. However, we also found that while these derivative financial instruments are useful hedges against the risks of issuing long-term financing instruments, they also expose derivative users to credit, contract

Recent updates on lignocellulosic biomass derived ethanol - A review

Directory of Open Access Journals (Sweden)

Rajeev Kumar

2016-03-01

Full Text Available Lignocellulosic (or cellulosic biomass derived ethanol is the most promising near/long term fuel candidate. In addition, cellulosic biomass derived ethanol may serve a precursor to other fuels and chemicals that are currently derived from unsustainable sources and/or are proposed to be derived from cellulosic biomass. However, the processing cost for second generation ethanol is still high to make the process commercially profitable and replicable. In this review, recent trends in cellulosic biomass ethanol derived via biochemical route are reviewed with main focus on current research efforts that are being undertaken to realize high product yields/titers and bring the overall cost down.

Higher-Order and Symbolic Computation

DEFF Research Database (Denmark)

Danvy, Olivier; Mason, Ian

2008-01-01

a series of implementaions that properly account for multiple invocations of the derivative-taking opeatro. In "Adapting Functional Programs to Higher-Order Logic," Scott Owens and Konrad Slind present a variety of examples of terminiation proofs of functional programs written in HOL proof systems. Since......-calculus programs, historically. The anaylsis determines the possible locations of ambients and mirrors the temporla sequencing of actions in the structure of types....

Gauge formulation for higher order gravity

International Nuclear Information System (INIS)

Cuzinatto, R.R.; Medeiros, L.G.; Melo, C.A.M. de; Pompeia, P.J.

2008-01-01

This work is an application of the second order gauge theory for the Lorentz group, where a description of the gravitational interaction is obtained that includes derivatives of the curvature. We analyze the form of the second field strength, G=∂F+fAF, in terms of geometrical variables. All possible independent Lagrangians constructed with quadratic contractions of F and quadratic contractions of G are analyzed. The equations of motion for a particular Lagrangian, which is analogous to Podolsky's term of his generalized electrodynamics, are calculated. The static isotropic solution in the linear approximation was found, exhibiting the regular Newtonian behavior at short distances as well as a meso-large distance modification. (orig.)

Separation of (Rh-103m)-rhodocene-derivatives from the parent (/sup 103/Ru)ruthenocen-derivatives and their organ distribution

Energy Technology Data Exchange (ETDEWEB)

Wenzel, M.; Wu, Y.

1987-01-01

The radioactive decay of (/sup 103/Ru)ruthenocene derivatives leads to sup(103m)Rh labelled rhodocinium derivatives, which can be separated by the extraction of a lipophilic solution of the ruthenocen derivate with water. The separation factor sup(103m)Rh//sup 103/Ru reaches values of 32:1 Rh/sup 3 +/ ions are not liberated and extracted. The organ distribution of the sup(103m)Rh labelled rhodocinium derivatives gained from ruthenocene and from N-isopropyl-ruthenocene amphetamine is different from the distribution of the parent ruthenocene compound. The liver and kidney uptake of the rhodocinium-amphetamine is much higher than the uptake with ruthenocene amphetamine.

Preliminary evaluation of the encapsulation of new antidiabetic sulphonylhydrazone and antitumor N-acylhydrazone derivatives using PLGA nanoparticles

International Nuclear Information System (INIS)

Costa, F N; Ibiapino, A L; De Figueiredo, L P; De Castro, C E; Giacomelli, F C; Ferreira, F F; Barreiro, E J; Lima, L M; Do Amaral, D N

2015-01-01

It has been demonstrated the feasibly of using PLGA nanoparticles to promote the encapsulation of novel anti-diabetic sulphonylhydrazone and antitumor N-acylhydrazone derivatives. The motivation is to further demonstrate the possibility of long-term release of anti-diabetic as well as higher accumulation of the antitumor derivative by using the nanotechnology-based production. The produced nanoparticles were obtained by the nanoprecipitation method, which revealed to be effective in the encapsulation of the bioactive compounds. The determined sizes were in the range of ∼100 nm, which are supposed to be suitable for both potential applications. The preliminary experimental data demonstrated the formation of stable nanosystems and further experiments are underway in order to determine the loading content, encapsulation efficiency and release profile of the hydrophobic bioactive compounds. (paper)

Spatial Rotation of the Fractional Derivative in Two-Dimensional Space

Directory of Open Access Journals (Sweden)

Ehab Malkawi

2015-01-01

Full Text Available The transformations of the partial fractional derivatives under spatial rotation in R2 are derived for the Riemann-Liouville and Caputo definitions. These transformation properties link the observation of physical quantities, expressed through fractional derivatives, with respect to different coordinate systems (observers. It is the hope that such understanding could shed light on the physical interpretation of fractional derivatives. Also it is necessary to be able to construct interaction terms that are invariant with respect to equivalent observers.

Inundation Mapping Tidal Surface - Mean Higher High Water

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — These data are a derived product of the NOAA VDatum tool and they extend the tool's Mean Higher High Water (MHHW) tidal datum conversion inland beyond its original...

On induced action for conformal higher spins in curved background

Energy Technology Data Exchange (ETDEWEB)

Beccaria, Matteo, E-mail: matteo.beccaria@le.infn.it [Dipartimento di Matematica e Fisica Ennio De Giorgi, Università del Salento & INFN, Via Arnesano, 73100 Lecce (Italy); Tseytlin, Arkady A., E-mail: tseytlin@imperial.ac.uk [The Blackett Laboratory, Imperial College, London SW7 2AZ (United Kingdom)

2017-06-15

We continue the investigation of the structure of the action for a tower of conformal higher spin fields in non-trivial 4d background metric recently discussed in Grigoriev and Tseytlin (2016). The action is defined as an induced one from path integral of a conformal scalar field in curved background coupled to higher spin fields. We analyze in detail the dependence of the quadratic part of the induced action on the spin 1 and spin 3 fields, determining the presence of a curvature-dependent mixed spin 1–3 term. One consequence is that the pure spin 3 kinetic term cannot be gauge-invariant on its own beyond the leading term in small curvature expansion. We also compute the non-zero contribution of the 1–3 mixing term to the conformal anomaly c-coefficient. One is thus to determine all such mixing terms before addressing the question of possible vanishing of the total c-coefficient in the conformal higher spin theory.

On induced action for conformal higher spins in curved background

Directory of Open Access Journals (Sweden)

Matteo Beccaria

2017-06-01

Full Text Available We continue the investigation of the structure of the action for a tower of conformal higher spin fields in non-trivial 4d background metric recently discussed in Grigoriev and Tseytlin (2016 [15]. The action is defined as an induced one from path integral of a conformal scalar field in curved background coupled to higher spin fields. We analyze in detail the dependence of the quadratic part of the induced action on the spin 1 and spin 3 fields, determining the presence of a curvature-dependent mixed spin 1–3 term. One consequence is that the pure spin 3 kinetic term cannot be gauge-invariant on its own beyond the leading term in small curvature expansion. We also compute the non-zero contribution of the 1–3 mixing term to the conformal anomaly c-coefficient. One is thus to determine all such mixing terms before addressing the question of possible vanishing of the total c-coefficient in the conformal higher spin theory.

Effects of coral-derived organic matter on the growth of bacterioplankton and heterotrophic nanoflagellates

Science.gov (United States)

Nakajima, Ryota; Tanaka, Yasuaki; Guillemette, Ryan; Kurihara, Haruko

2017-12-01

Exudates derived from hermatypic corals were incubated with dark conditions for 96 h to quantify the growth of both bacteria and HNF in response to coral-derived dissolved organic matter (DOM). The addition of coral-derived DOM caused significantly higher growth rates and production of bacteria and HNF compared to those in control seawater without coral exudates. During the incubation, HNF exhibited their peak in abundance 24-48 h after the peak abundance of bacteria. The growth efficiencies of both bacteria and HNF were significantly higher with coral-derived DOM, suggesting higher transfer efficiency from bacteria that is fueled by coral organic matter to HNF. Therefore, trophic transfer of coral-derived DOM from bacteria to HNF can contribute to efficient carbon flow through the microbial food web.

Long-Term Results of Cartilage Repair after Allogeneic Transplantation of Cartilaginous Aggregates Formed from Bone Marrow–Derived Cells for Large Osteochondral Defects in Rabbit Knees

Science.gov (United States)

Mishima, Hajime; Sakai, Shinsuke; Uemura, Toshimasa

2013-01-01

Objective: The purpose of this study was to evaluate the long-term results of cartilage repair after allogeneic transplantation of cartilaginous aggregates formed from bone marrow–derived cells. Methods: Bone marrow cells were harvested from 12-day-old rabbits. The cells were subjected to a monolayer culture, and the spindle-shaped cells attached to the flask surface were defined as bone marrow–derived mesenchymal cells. After the monolayer culture, a 3-dimensional cartilaginous aggregate was formed using a bioreactor with chondrogenesis. We created osteochondral defects, measuring 5 mm in diameter and 4 mm in depth, at the femoral trochlea of 10-week-old rabbits. Two groups were established, the transplanted group in which the cartilaginous aggregate was transplanted into the defect, and the control group in which the defect was left untreated. Twenty-six and 52 weeks after surgery, the rabbits were sacrificed and their tissue repair status was evaluated macroscopically (International Cartilage Repair Society [ICRS] score) and histologically (O’Driscoll score). Results: The ICRS scores were as follows: at week 26, 7.2 ± 0.5 and 7.6 ± 0.8; at week 52, 7.6 ± 1.1 and 9.7 ± 0.7, for the transplanted and control groups, respectively. O’Driscoll scores were as follows: at week 26, 12.6 ± 1.9 and 10.1 ± 1.9; at week 52, 9.6 ± 3.0 and 14.0 ± 1.4, each for transplanted and control groups, respectively. No significant differences were observed between the groups. Conclusions: This study demonstrates that allogeneic transplantation of cartilaginous aggregates formed from bone marrow–derived cells produces comparable long-term results based on macroscopic and histological outcome measures when compared with osteochondral defects that are left untreated. PMID:26069678

Long-Term Results of Cartilage Repair after Allogeneic Transplantation of Cartilaginous Aggregates Formed from Bone Marrow-Derived Cells for Large Osteochondral Defects in Rabbit Knees.

Science.gov (United States)

Yoshioka, Tomokazu; Mishima, Hajime; Sakai, Shinsuke; Uemura, Toshimasa

2013-10-01

The purpose of this study was to evaluate the long-term results of cartilage repair after allogeneic transplantation of cartilaginous aggregates formed from bone marrow-derived cells. Bone marrow cells were harvested from 12-day-old rabbits. The cells were subjected to a monolayer culture, and the spindle-shaped cells attached to the flask surface were defined as bone marrow-derived mesenchymal cells. After the monolayer culture, a 3-dimensional cartilaginous aggregate was formed using a bioreactor with chondrogenesis. We created osteochondral defects, measuring 5 mm in diameter and 4 mm in depth, at the femoral trochlea of 10-week-old rabbits. Two groups were established, the transplanted group in which the cartilaginous aggregate was transplanted into the defect, and the control group in which the defect was left untreated. Twenty-six and 52 weeks after surgery, the rabbits were sacrificed and their tissue repair status was evaluated macroscopically (International Cartilage Repair Society [ICRS] score) and histologically (O'Driscoll score). The ICRS scores were as follows: at week 26, 7.2 ± 0.5 and 7.6 ± 0.8; at week 52, 7.6 ± 1.1 and 9.7 ± 0.7, for the transplanted and control groups, respectively. O'Driscoll scores were as follows: at week 26, 12.6 ± 1.9 and 10.1 ± 1.9; at week 52, 9.6 ± 3.0 and 14.0 ± 1.4, each for transplanted and control groups, respectively. No significant differences were observed between the groups. This study demonstrates that allogeneic transplantation of cartilaginous aggregates formed from bone marrow-derived cells produces comparable long-term results based on macroscopic and histological outcome measures when compared with osteochondral defects that are left untreated.

Source term derivation and radiological safety analysis for the TRICO II research reactor in Kinshasa

International Nuclear Information System (INIS)

Muswema, J.L.; Ekoko, G.B.; Lukanda, V.M.; Lobo, J.K.-K.; Darko, E.O.; Boafo, E.K.

2015-01-01

Highlights: • Atmospheric dispersion modeling for two credible accidents of the TRIGA Mark II research reactor in Kinshasa (TRICO II) was performed. • Radiological safety analysis after the postulated initiating events (PIE) was also carried out. • The Karlsruhe KORIGEN and the HotSpot Health Physics codes were used to achieve the objectives of this study. • All the values of effective dose obtained following the accident scenarios were below the regulatory limits for reactor staff members and the public, respectively. - Abstract: The source term from the 1 MW TRIGA Mark II research reactor core of the Democratic Republic of the Congo was derived in this study. An atmospheric dispersion modeling followed by radiation dose calculation were performed based on two possible postulated accident scenarios. This derivation was made from an inventory of peak radioisotope activities released in the core by using the Karlsruhe version of isotope generation code KORIGEN. The atmospheric dispersion modeling was performed with HotSpot code, and its application yielded to radiation dose profile around the site using meteorological parameters specific to the area under study. The two accident scenarios were picked from possible accident analyses for TRIGA and TRIGA-fueled reactors, involving the case of destruction of the fuel element with highest activity release and a plane crash on the reactor building as the worst case scenario. Deterministic effects of these scenarios are used to update the Safety Analysis Report (SAR) of the reactor, and for its current version, these scenarios are not yet incorporated. Site-specific meteorological conditions were collected from two meteorological stations: one installed within the Atomic Energy Commission and another at the National Meteorological Agency (METTELSAT), which is not far from the site. Results show that in both accident scenarios, radiation doses remain within the limits, far below the recommended maximum effective

Source term derivation and radiological safety analysis for the TRICO II research reactor in Kinshasa

Energy Technology Data Exchange (ETDEWEB)

Muswema, J.L., E-mail: jeremie.muswem@unikin.ac.cd [Faculty of Science, University of Kinshasa, P.O. Box 190, KIN XI (Congo, The Democratic Republic of the); Ekoko, G.B. [Faculty of Science, University of Kinshasa, P.O. Box 190, KIN XI (Congo, The Democratic Republic of the); Lukanda, V.M. [Faculty of Science, University of Kinshasa, P.O. Box 190, KIN XI (Congo, The Democratic Republic of the); Democratic Republic of the Congo' s General Atomic Energy Commission, P.O. Box AE1 (Congo, The Democratic Republic of the); Lobo, J.K.-K. [Faculty of Science, University of Kinshasa, P.O. Box 190, KIN XI (Congo, The Democratic Republic of the); Darko, E.O. [Radiation Protection Institute, Ghana Atomic Energy Commission, P.O. Box LG 80, Legon, Accra (Ghana); Boafo, E.K. [University of Ontario Institute of Technology, 2000 Simcoe St. North, Oshawa, ONL1 H7K4 (Canada)

2015-01-15

Highlights: • Atmospheric dispersion modeling for two credible accidents of the TRIGA Mark II research reactor in Kinshasa (TRICO II) was performed. • Radiological safety analysis after the postulated initiating events (PIE) was also carried out. • The Karlsruhe KORIGEN and the HotSpot Health Physics codes were used to achieve the objectives of this study. • All the values of effective dose obtained following the accident scenarios were below the regulatory limits for reactor staff members and the public, respectively. - Abstract: The source term from the 1 MW TRIGA Mark II research reactor core of the Democratic Republic of the Congo was derived in this study. An atmospheric dispersion modeling followed by radiation dose calculation were performed based on two possible postulated accident scenarios. This derivation was made from an inventory of peak radioisotope activities released in the core by using the Karlsruhe version of isotope generation code KORIGEN. The atmospheric dispersion modeling was performed with HotSpot code, and its application yielded to radiation dose profile around the site using meteorological parameters specific to the area under study. The two accident scenarios were picked from possible accident analyses for TRIGA and TRIGA-fueled reactors, involving the case of destruction of the fuel element with highest activity release and a plane crash on the reactor building as the worst case scenario. Deterministic effects of these scenarios are used to update the Safety Analysis Report (SAR) of the reactor, and for its current version, these scenarios are not yet incorporated. Site-specific meteorological conditions were collected from two meteorological stations: one installed within the Atomic Energy Commission and another at the National Meteorological Agency (METTELSAT), which is not far from the site. Results show that in both accident scenarios, radiation doses remain within the limits, far below the recommended maximum effective

Recurrence approach and higher order polynomial algebras for superintegrable monopole systems

Science.gov (United States)

Hoque, Md Fazlul; Marquette, Ian; Zhang, Yao-Zhong

2018-05-01

We revisit the MIC-harmonic oscillator in flat space with monopole interaction and derive the polynomial algebra satisfied by the integrals of motion and its energy spectrum using the ad hoc recurrence approach. We introduce a superintegrable monopole system in a generalized Taub-Newman-Unti-Tamburino (NUT) space. The Schrödinger equation of this model is solved in spherical coordinates in the framework of Stäckel transformation. It is shown that wave functions of the quantum system can be expressed in terms of the product of Laguerre and Jacobi polynomials. We construct ladder and shift operators based on the corresponding wave functions and obtain the recurrence formulas. By applying these recurrence relations, we construct higher order algebraically independent integrals of motion. We show that the integrals form a polynomial algebra. We construct the structure functions of the polynomial algebra and obtain the degenerate energy spectra of the model.

Hamiltonian derivation of a gyrofluid model for collisionless magnetic reconnection

International Nuclear Information System (INIS)

Tassi, E

2014-01-01

We consider a simple electromagnetic gyrokinetic model for collisionless plasmas and show that it possesses a Hamiltonian structure. Subsequently, from this model we derive a two-moment gyrofluid model by means of a procedure which guarantees that the resulting gyrofluid model is also Hamiltonian. The first step in the derivation consists of imposing a generic fluid closure in the Poisson bracket of the gyrokinetic model, after expressing such bracket in terms of the gyrofluid moments. The constraint of the Jacobi identity, which every Poisson bracket has to satisfy, selects then what closures can lead to a Hamiltonian gyrofluid system. For the case at hand, it turns out that the only closures (not involving integro/differential operators or an explicit dependence on the spatial coordinates) that lead to a valid Poisson bracket are those for which the second order parallel moment, independently for each species, is proportional to the zero order moment. In particular, if one chooses an isothermal closure based on the equilibrium temperatures and derives accordingly the Hamiltonian of the system from the Hamiltonian of the parent gyrokinetic model, one recovers a known Hamiltonian gyrofluid model for collisionless reconnection. The proposed procedure, in addition to yield a gyrofluid model which automatically conserves the total energy, provides also, through the resulting Poisson bracket, a way to derive further conservation laws of the gyrofluid model, associated with the so called Casimir invariants. We show that a relation exists between Casimir invariants of the gyrofluid model and those of the gyrokinetic parent model. The application of such Hamiltonian derivation procedure to this two-moment gyrofluid model is a first step toward its application to more realistic, higher-order fluid or gyrofluid models for tokamaks. It also extends to the electromagnetic gyrokinetic case, recent applications of the same procedure to Vlasov and drift- kinetic systems

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Directory of Open Access Journals (Sweden)

R. N. Bárcia

2015-01-01

Full Text Available MSCs derived from the umbilical cord tissue, termed UCX, were investigated for their immunomodulatory properties and compared to bone marrow-derived MSCs (BM-MSCs, the gold-standard in immunotherapy. Immunogenicity and immunosuppression were assessed by mixed lymphocyte reactions, suppression of lymphocyte proliferation and induction of regulatory T cells. Results showed that UCX were less immunogenic and showed higher immunosuppression activity than BM-MSCs. Further, UCX did not need prior activation or priming to exert their immunomodulatory effects. This was further corroborated in vivo in a model of acute inflammation. To elucidate the potency differences observed between UCX and BM-MSCs, gene expression related to immune modulation was analysed in both cell types. Several gene expression profile differences were found between UCX and BM-MSCs, namely decreased expression of HLA-DRA, HO-1, IGFBP1, 4 and 6, ILR1, IL6R and PTGES and increased expression of CD200, CD273, CD274, IL1B, IL-8, LIF and TGFB2. The latter were confirmed at the protein expression level. Overall, these results show that UCX seem to be naturally more potent immunosuppressors and less immunogenic than BM-MSCs. We propose that these differences may be due to increased levels of immunomodulatory surface proteins such as CD200, CD273, CD274 and cytokines such as IL1β, IL-8, LIF and TGFβ2.

APPROACH TO QUALITY ASSURANCE IN HIGHER EDUCATION

Directory of Open Access Journals (Sweden)

Zora Arsovski

2007-03-01

Full Text Available Quality assurance in higher education is streamed in two interconnected concepts: (1 quality management according to ISO 9000 and (2 Bologna process. In this paper both concepts are presented, with point on internal state and term plan activities for quality improvement in higher education in Serbia.

Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles.

Directory of Open Access Journals (Sweden)

Rupak Dua

Full Text Available We investigated the effectiveness of integrating tissue engineered cartilage derived from human bone marrow derived stem cells (HBMSCs to healthy as well as osteoarthritic cartilage mimics using hydroxyapatite (HA nanoparticles immersed within a hydrogel substrate. Healthy and diseased engineered cartilage from human chondrocytes (cultured in agar gels were integrated with human bone marrow stem cell (HBMSC-derived cartilaginous engineered matrix with and without HA, and evaluated after 28 days of growth. HBMSCs were seeded within photopolymerizable poly (ethylene glycol diacrylate (PEGDA hydrogels. In addition, we also conducted a preliminary in vivo evaluation of cartilage repair in rabbit knee chondral defects treated with subchondral bone microfracture and cell-free PEGDA with and without HA. Under in vitro conditions, the interfacial shear strength between tissue engineered cartilage derived from HBMSCs and osteoarthritic chondrocytes was significantly higher (p < 0.05 when HA nanoparticles were incorporated within the HBMSC culture system. Histological evidence confirmed a distinct spatial transition zone, rich in calcium phosphate deposits. Assessment of explanted rabbit knees by histology demonstrated that cellularity within the repair tissues that had filled the defects were of significantly higher number (p < 0.05 when HA was used. HA nanoparticles play an important role in treating chondral defects when osteoarthritis is a co-morbidity. We speculate that the calcified layer formation at the interface in the osteoarthritic environment in the presence of HA is likely to have attributed to higher interfacial strength found in vitro. From an in vivo standpoint, the presence of HA promoted cellularity in the tissues that subsequently filled the chondral defects. This higher presence of cells can be considered important in the context of accelerating long-term cartilage remodeling. We conclude that HA nanoparticles play an important role in

Australian OTC Derivatives Markets: Insights from the BIS Semiannual Survey

OpenAIRE

Jason Ahn; Mihovil Matic; Christian Vallence

2012-01-01

The Reserve Bank of Australia recently commenced surveying participants in Australian over-the-counter (OTC) derivatives markets as part of the Bank for International Settlements’ (BIS) semiannual global OTC derivatives survey. Australia’s contribution to the survey complements regulatory efforts to improve the resilience and transparency of Australia’s OTC derivatives markets. It also facilitates a higher frequency comparison of the Australian and foreign OTC derivatives markets. The survey ...

Kinetic Theory Derivation of the Adiabatic Law for Ideal Gases.

Science.gov (United States)

Sobel, Michael I.

1980-01-01

Discusses how the adiabatic law for ideal gases can be derived from the assumption of a Maxwell-Boltzmann (or any other) distribution of velocities--in contrast to the usual derivations from thermodynamics alone, and the higher-order effect that leads to one-body viscosity. An elementary derivation of the adiabatic law is given. (Author/DS)

Foreign transfers and tropical deforestation : what terms of conditionality

NARCIS (Netherlands)

Soest, Daan van; Lensink, Robert

1997-01-01

The purpose of this paper is to propose a nonparametric interest rate term structure model and investigate its implications on term structure dynamics and prices of interest rate derivative securities. The nonparametric spot interest rate process is estimated from the observed short-term interest

NSSEFF Designing New Higher Temperature Superconductors

Science.gov (United States)

2017-04-13

AFRL-AFOSR-VA-TR-2017-0083 NSSEFF - DESIGINING NEW HIGHER TEMPERATURE SUPERCONDUCTORS Meigan Aronson THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF...2015 4. TITLE AND SUBTITLE NSSEFF - DESIGINING NEW HIGHER TEMPERATURE SUPERCONDUCTORS 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-10-1-0191 5c...materials, identifying the most promising candidates. 15. SUBJECT TERMS TEMPERATURE, SUPERCONDUCTOR 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF

10 CFR 603.1280 - Institution of higher education.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Institution of higher education. 603.1280 Section 603.1280... Definitions of Terms Used in this Part § 603.1280 Institution of higher education. An educational institution that: (a) Meets the criteria in section 101 of the Higher Education Act of 1965 (20 U.S.C. 1001); and...

Asian Women in Higher Education: Shared Communities

Science.gov (United States)

Bhopal, Kalwant

2010-01-01

More Asian women are entering higher education in the UK than ever before, and the number looks likely to rise. Their engagement with higher education reflects widespread changes in the attitudes and cultural expectations of their various communities, as awareness grows of the greater long-term value associated with continuing in education. Today…

Standard molar enthalpies of formation of three methyl-pyrazole derivatives

International Nuclear Information System (INIS)

Ribeiro da Silva, Manuel A.V.; Cabral, Joana I.T.A.

2012-01-01

Highlights: ► Combustion calorimetry was used to determine Δ f H m ∘ (cr) of methyl-pyrazole derivatives. ► Vapour pressures were determined by the Knudsen mass-loss effusion technique. ► Gas-phase Δ f H m ∘ of the studied compounds have been derived. - Abstract: The standard (p ° = 0.1 MPa) molar enthalpies of formation of the crystalline 3-methyl-1-pyrazolecarboxamide; 3-methyl-3-pyrazoline-5-one; and 4-methyl-2-pyrazoline-5-one were derived from the standard massic energies of combustion, in oxygen, to yield CO 2 (g), H 2 O (l) and N 2 (g), at T = 298.15 K, measured by static bomb combustion calorimetry. The standard molar enthalpies of sublimation were calculated from the variation of the vapour pressures of each compound with temperature, measured by the Knudsen effusion technique. These two thermodynamic parameters yielded the standard molar enthalpies of formation of the pyrazole derivatives, in the gaseous phase, at T = 298.15 K. The derived standard molar enthalpies of formation, in gaseous state, are analyzed in terms of enthalpic increments and interpreted in terms of molecular structure.

Higher-Order Hierarchical Legendre Basis Functions in Applications

DEFF Research Database (Denmark)

Kim, Oleksiy S.; Jørgensen, Erik; Meincke, Peter

2007-01-01

The higher-order hierarchical Legendre basis functions have been developed for effective solution of integral equations with the method of moments. They are derived from orthogonal Legendre polynomials modified to enforce normal continuity between neighboring mesh elements, while preserving a high...

Isolation and Osteogenic Differentiation of Rat Periosteum-derived Cells

OpenAIRE

Declercq, Heidi Andrea; De Ridder, Leo Isabelle; Cornelissen, Maria Jozefa

2005-01-01

Selection of appropriate cultures having an osteogenic potential is a necessity if cell/biomaterial interactions are studied in long-term cultures. Osteoblastic cells derived from rat long bones or calvaria have the disadvantage of being in an advanced differentiation stage which results in terminal differentiation within 21 days. In this regard, less differentiated periosteum-derived osteoprogenitors could be more suitable.

Higher-spin algebras, holography and flat space

Energy Technology Data Exchange (ETDEWEB)

Sleight, C. [Max-Planck-Institut für Physik (Werner-Heisenberg-Institut),Föhringer Ring 6, D-80805 Munich (Germany); Université Libre de Bruxelles and International Solvay Institutes,ULB-Campus Plaine CP231, 1050 Brussels (Belgium); Taronna, M. [Université Libre de Bruxelles and International Solvay Institutes,ULB-Campus Plaine CP231, 1050 Brussels (Belgium)

2017-02-20

In this article we study the higher-spin algebra behind the type-A cubic couplings recently extracted from the free O(N) model in generic dimensions, demonstrating that they coincide with the known structure constants for the unique higher-spin algebra in generic dimensions. This provides an explicit check of the holographic reconstruction and of the duality between higher-spin theories and the free O(N) model in generic dimensions, generalising the result of Giombi and Yin in AdS{sub 4}. For completeness, we also address the same problem in the flat space for the cubic couplings derived by Metsaev in 1991, which are recovered from the flat limit of the AdS type-A cubic couplings. We observe that both flat and AdS{sub 4} higher-spin Lorentz subalgebras coincide, hinting towards the existence of a full higher-spin symmetry behind the flat-space cubic couplings of Metsaev.

A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein.

Science.gov (United States)

Xiao, Yangming; Russell, I Jon; Liu, Ya-Guang

2012-08-01

A common single nucleotide polymorphism (SNP) in the gene of brain-derived neurotrophic factor (BDNF) results from a substitution at position 66 from valine (Val) to methionine (Met) and may predispose to human neuropsychiatric disorders. We proposed to determine whether these BDNF gene SNPs were associated with fibromyalgia syndrome (FMS) and/or any of its typical phenotypes. Patients with FMS (N = 95) and healthy normal controls (HNC, N = 58) were studied. Serum high-sensitivity C-reactive protein (hsCRP) levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BDNF SNPs were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The BDNF SNP distribution was 65 (68%) Val/Val, 28 (30%) Val/Met, and 2 (2%) Met/Met for FMS and 40 (69%), 17(29%), and 1 (2%) for HNC, respectively. The serum high-sensitivity C-reactive protein (hsCRP)and body mass index (BMI) in FMS were higher than in HNC. The FMS with BDNF Val66Val had significantly higher mean BMI (P = 0.0001) and hsCRP (P = 0.02) than did FMS carrying the Val66Met genotype. This pattern was not found in HNC. Phenotypic measures of subjective pain, pain threshold, depression, or insomnia did not relate to either of the BDNF SNPs in FMS. The relative distribution BDNF SNPs did not differ between FMS and HNC. The BDNF Val66Met polymorphism is not selective for FMS. The BDNF Val66Val SNP identifies a subgroup of FMS with elevated hsCRP and higher BMI. This is the first study to associate a BDNF polymorphism with a FMS subgroup phenotype.

Particle production after inflation with non-minimal derivative coupling to gravity

International Nuclear Information System (INIS)

Ema, Yohei; Jinno, Ryusuke; Nakayama, Kazunori; Mukaida, Kyohei

2015-01-01

We study cosmological evolution after inflation in models with non-minimal derivative coupling to gravity. The background dynamics is solved and particle production associated with rapidly oscillating Hubble parameter is studied in detail. In addition, production of gravitons through the non-minimal derivative coupling with the inflaton is studied. We also find that the sound speed squared of the scalar perturbation oscillates between positive and negative values when the non-minimal derivative coupling dominates over the minimal kinetic term. This may lead to an instability of this model. We point out that the particle production rates are the same as those in the Einstein gravity with the minimal kinetic term, if we require the sound speed squared is positive definite

Higher spins and Yangian symmetries

Energy Technology Data Exchange (ETDEWEB)

Gaberdiel, Matthias R. [Institut für Theoretische Physik, ETH Zurich, CH-8093 Zurich (Switzerland); Gopakumar, Rajesh [International Centre for Theoretical Sciences-TIFR, Survey No. 151, Shivakote, Hesaraghatta Hobli, Bengaluru North 560 089 (India); Li, Wei [CAS Key Laboratory of Theoretical Physics,Institute of Theoretical Physics, Chinese Academy of Sciences,100190 Beijing (China); Peng, Cheng [Department of Physics, Brown University, 182 Hope Street, Providence, RI 02912 (United States)

2017-04-26

The relation between the bosonic higher spin W{sub ∞}[λ] algebra, the affine Yangian of gl{sub 1}, and the SH{sup c} algebra is established in detail. For generic λ we find explicit expressions for the low-lying W{sub ∞}[λ] modes in terms of the affine Yangian generators, and deduce from this the precise identification between λ and the parameters of the affine Yangian. Furthermore, for the free field cases corresponding to λ=0 and λ=1 we give closed-form expressions for the affine Yangian generators in terms of the free fields. Interestingly, the relation between the W{sub ∞} modes and those of the affine Yangian is a non-local one, in general. We also establish the explicit dictionary between the affine Yangian and the SH{sup c} generators. Given that Yangian algebras are the hallmark of integrability, these identifications should pave the way towards uncovering the relation between the integrable and the higher spin symmetries.

Depletion and capture: revisiting “The source of water derived from wells"

Science.gov (United States)

Konikow, Leonard F.; Leake, Stanley A.

2014-01-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems.

R4 terms in supergravities via T -duality constraint

Science.gov (United States)

Razaghian, Hamid; Garousi, Mohammad R.

2018-05-01

It has been speculated in the literature that the effective actions of string theories at any order of α' should be invariant under the Buscher rules plus their higher covariant-derivative corrections. This may be used as a constraint to find effective actions at any order of α', in particular, the metric, the B -field, and the dilaton couplings in supergravities at order α'3 up to an overall factor. For the simple case of zero B -field and diagonal metric in which we have done the calculations explicitly, we have found that the constraint fixes almost all of the seven independent Riemann curvature couplings. There is only one term which is not fixed, because when metric is diagonal, the reduction of two R4 terms becomes identical. The Riemann curvature couplings that the T -duality constraint produces for both type II and heterotic theories are fully consistent with the existing couplings in the literature which have been found by the S-matrix and by the sigma-model approaches.

Markers of pathological excitability derived from principal dynamic modes of hippocampal neurons

Science.gov (United States)

Kang, Eunji E.; Zalay, Osbert C.; Serletis, Demitre; Carlen, Peter L.; Bardakjian, Berj L.

2012-10-01

Transformation of principal dynamic modes (PDMs) under epileptogenic conditions was investigated by computing the Volterra kernels in a rodent epilepsy model derived from a mouse whole hippocampal preparation, where epileptogenesis was induced by altering the concentrations of Mg2 + and K+ of the perfusate for different levels of excitability. Both integrating and differentiating PDMs were present in the neuronal dynamics, and both of them increased in absolute magnitude for increased excitability levels. However, the integrating PDMs dominated at all levels of excitability in terms of their relative contributions to the overall response, whereas the dominant frequency responses of the differentiating PDMs were shifted to higher ranges under epileptogenic conditions, from ripple activities (75-200 Hz) to fast ripple activities (200-500 Hz).

Conceptual DFT: the chemical relevance of higher response functions.

Science.gov (United States)

Geerlings, P; De Proft, F

2008-06-07

.g. on the local and global polarizability. Its derivatives may govern the influence of charge on the polarizability, the R-analogues being the nuclear Fukui function and the quadratic and cubic force constants. Although some of the higher order derivatives may be difficult to evaluate a comparison with the energy expansion used in spectroscopy in terms of nuclear displacements, nuclear magnetic moments, electric and magnetic fields leads to the conjecture that, certainly cross terms may contain new, intricate information for understanding chemical reactivity.

Quantum field theory on higher-genus Riemann surfaces

International Nuclear Information System (INIS)

Kubo, Reijiro; Yoshii, Hisahiro; Ojima, Shuichi; Paul, S.K.

1989-07-01

Quantum field theory for b-c systems is formulated on Riemann surfaces with arbitrary genus. We make use of the formalism recently developed by Krichever and Novikov. Hamiltonian is defined properly, and the Ward-Takahashi identities are derived on higher-genus Riemann surfaces. (author)

Are Higher Education Institutions Prepared for Learning Analytics?

Science.gov (United States)

Ifenthaler, Dirk

2017-01-01

Higher education institutions and involved stakeholders can derive multiple benefits from learning analytics by using different data analytics strategies to produce summative, real-time, and predictive insights and recommendations. However, are institutions and academic as well as administrative staff prepared for learning analytics? A learning…

Synthesis, antioxidative and whitening effects of novel cysteine derivatives

Energy Technology Data Exchange (ETDEWEB)

Ha, Ji Hoon; Kim, Kyoung Mi; Jeong, Yoon Ju; Park, Young Min; Lee, Jae Young; Park, Soo Nam [Dept. of Fine Chemistry, Cosmetic R and D Center, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, Seoul (Korea, Republic of); Park, Jino [Daebong LS. Ltd, Incheon (Korea, Republic of)

2017-01-15

Recently, development of biocompatibility functional cosmetic agents as antioxidant or whitening agent has increased. In this study, synthetic cysteine derivatives (DBLS-21, -24, and -33) were developed containing syringic acid and cysteine moieties (l-cysteine ethyl ester, N-acetyl cysteine methyl ester, and N-acetyl cysteine ethyl ester), and their antioxidative and whitening activities were evaluated. The cellular protective effect (τ{sub 50}) of DBLS-21 was 51.1 min at 50 μM on {sup 1}O{sub 2} -induced hemolysis of erythrocytes. This activity was slightly higher than that of α-tocopherol (43.6 min) as a lipophilic antioxidant. In the melanogenesis inhibitory effect, DBLS-21, -24, and -33 was 1.6-, 1.8-, and 2.5-fold higher than arbutin, respectively. In particular, DBLS-21 and -33 was 112.8- and 6.1-fold higher than arbutin, respectively (293.4 μM) on tyrosinase inhibition activity (IC{sub 50} ). But DBLS-24 had no tyrosinase inhibitory activity. These results suggest that cysteine derivatives possess potential for use as an antioxidant agent (DBLS-21) and whitening agents (all derivatives) in cosmetics.

Synthesis, antioxidative and whitening effects of novel cysteine derivatives

International Nuclear Information System (INIS)

Ha, Ji Hoon; Kim, Kyoung Mi; Jeong, Yoon Ju; Park, Young Min; Lee, Jae Young; Park, Soo Nam; Park, Jino

2017-01-01

Recently, development of biocompatibility functional cosmetic agents as antioxidant or whitening agent has increased. In this study, synthetic cysteine derivatives (DBLS-21, -24, and -33) were developed containing syringic acid and cysteine moieties (l-cysteine ethyl ester, N-acetyl cysteine methyl ester, and N-acetyl cysteine ethyl ester), and their antioxidative and whitening activities were evaluated. The cellular protective effect (τ_5_0) of DBLS-21 was 51.1 min at 50 μM on "1O_2 -induced hemolysis of erythrocytes. This activity was slightly higher than that of α-tocopherol (43.6 min) as a lipophilic antioxidant. In the melanogenesis inhibitory effect, DBLS-21, -24, and -33 was 1.6-, 1.8-, and 2.5-fold higher than arbutin, respectively. In particular, DBLS-21 and -33 was 112.8- and 6.1-fold higher than arbutin, respectively (293.4 μM) on tyrosinase inhibition activity (IC_5_0 ). But DBLS-24 had no tyrosinase inhibitory activity. These results suggest that cysteine derivatives possess potential for use as an antioxidant agent (DBLS-21) and whitening agents (all derivatives) in cosmetics

Term clouds as surrogates for user generated speech

NARCIS (Netherlands)

Tsagkias, M.; Larson, M.; de Rijke, M.; Myaeng, S.-H.; Oard, D.W.; Sebastiani, F.; Chua, T.-S.; Leong, M.-K.

2008-01-01

User generated spoken audio remains a challenge for Automatic Speech Recognition (ASR) technology and content-based audio surrogates derived from ASR-transcripts must be error robust. An investigation of the use of term clouds as surrogates for podcasts demonstrates that ASR term clouds closely

Experimental study on the thermochemistry of some amino derivatives of uracil

International Nuclear Information System (INIS)

Ribeiro da Silva, Manuel A.V.; Amaral, Luisa M.P.F.; Szterner, Piotr

2011-01-01

Highlights: → Combustion calorimetry was used to determine Δ f H m 0 (cr) of amino derivatives of uracil. → Gas-phase Δ f H m 0 of amino derivatives of uracil have been derived. → The relative enthalpic stability of the title compounds is discussed in structural terms. - Abstract: Values of the standard (p 0 = 0.1 MPa) molar enthalpy of combustion, Δ c H m 0 , of four crystalline compounds: 5-aminouracil, 6-aminouracil, 6-amino-1-methyluracil, and 6-amino-1,3-dimethyluracil, were determined, at T = 298.15 K, using a static bomb combustion calorimeter. The values obtained of standard molar enthalpy of combustion were used to derive the standard molar enthalpy of formation of the compounds investigated in their condensed phase and together with literature values of the standard molar enthalpy of sublimation, yielded the standard molar enthalpies of formation in the gaseous phase. These are discussed in terms of the effects of the molecular structure on the relative enthalpic stability.

Depletion and capture: revisiting "the source of water derived from wells".

Science.gov (United States)

Konikow, L F; Leake, S A

2014-09-01

A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Evidence of quantum phase transition in real-space vacuum entanglement of higher derivative scalar quantum field theories.

Science.gov (United States)

Kumar, S Santhosh; Shankaranarayanan, S

2017-11-17

In a bipartite set-up, the vacuum state of a free Bosonic scalar field is entangled in real space and satisfies the area-law- entanglement entropy scales linearly with area of the boundary between the two partitions. In this work, we show that the area law is violated in two spatial dimensional model Hamiltonian having dynamical critical exponent z = 3. The model physically corresponds to next-to-next-to-next nearest neighbour coupling terms on a lattice. The result reported here is the first of its kind of violation of area law in Bosonic systems in higher dimensions and signals the evidence of a quantum phase transition. We provide evidence for quantum phase transition both numerically and analytically using quantum Information tools like entanglement spectra, quantum fidelity, and gap in the energy spectra. We identify the cause for this transition due to the accumulation of large number of angular zero modes around the critical point which catalyses the change in the ground state wave function due to the next-to-next-to-next nearest neighbor coupling. Lastly, using Hubbard-Stratanovich transformation, we show that the effective Bosonic Hamiltonian can be obtained from an interacting fermionic theory and provide possible implications for condensed matter systems.

Chemical and proteolysis-derived changes during long-term storage of lactose-hydrolyzed ultrahigh-temperature (UHT) milk.

Science.gov (United States)

Jansson, Therese; Jensen, Hanne B; Sundekilde, Ulrik K; Clausen, Morten R; Eggers, Nina; Larsen, Lotte B; Ray, Colin; Andersen, Henrik J; Bertram, Hanne C

2014-11-19

Proteolytic activity in milk may release bitter-tasting peptides and generate free amino terminals that react with carbohydrates, which initiate Maillard reaction. Ultrahigh temperature (UHT) heat treatment inactivates the majority of proteolytic enzymes in milk. In lactose-hydrolyzed milk a β-galactosidase preparation is applied to the milk after heat treatment, which has proteolytic side activities that may induce quality deterioration of long-term-stored milk. In the present study proteolysis, glycation, and volatile compound formation were investigated in conventional (100% lactose), filtered (60% lactose), and lactose-hydrolyzed (<1% lactose) UHT milk using reverse phase high-pressure liquid chromatography-mass spectrometry, proton nuclear magnetic resonance, and gas chromatography-mass spectrometry. Proteolysis was observed in all milk types. However, the degree of proteolysis was significantly higher in the lactose-hydrolyzed milk compared to the conventional and filtered milk. The proteins most prone to proteolysis were β-CN and αs1-CN, which were clearly hydrolyzed after approximately 90 days of storage in the lactose-hydrolyzed milk.

Mathematics, Pricing, Market Risk Management and Trading Strategies for Financial Derivatives (1/3)

CERN Multimedia

CERN. Geneva; Coffey, Brian

2009-01-01

Abstract: An introduction to the mathematics and practicalities of market trading and risk management for financial derivatives, the course will focus on examples from the short-term and long term Foreign Exchange (FX) and Interest Rate (IR) derivatives markets. Topics: - Government Bonds and IR Curves - Stochastic FX, Black-Scholes Vanilla FX Options and Martingales - Risk Management and Market Trading for Vanilla FX Options, Market Implied Volatility, Valuation and Risk Management, Market Trading Strategies - Stochastic IR Curves and Implied Volatility, IR Derivatives - Long Term FX Options: Interaction of Stochastic FX and Stochastic IR Vanilla Foreign Exchange (FX) Options - $ Government Bonds, Interest Rate (IR) Curves, Continuous IR - Domestic ($) and Foreign (Yen) Government Bonds, IR curves - Stochastic Spot FX, Forward FX: Ito processes for $ and Yen Investors - Black-Scholes Vanilla FX Options, Connection to Heat/Diffusion Equation - Stochastic Differential Equations with Mart...

Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory.

Science.gov (United States)

Shih, Y-H; Tsai, S-F; Huang, S-H; Chiang, Y-T; Hughes, M W; Wu, S-Y; Lee, C-W; Yang, T-T; Kuo, Y-M

2016-05-13

Hypertension is associated with neurodegenerative diseases and cognitive impairment. Several studies using spontaneous hypertensive rats to study the effect of hypertension on memory performance and adult hippocampal neurogenesis have reached inconsistent conclusions. The contradictory findings may be related to the genetic variability of spontaneous hypertensive rats due to the conventional breeding practices. The objective of this study is to examine the effect of hypertension on hippocampal structure and function in isogenic mice. Hypertension was induced by the '2 kidneys, 1 clip' method (2K1C) which constricted one of the two renal arteries. The blood pressures of 2K1C mice were higher than the sham group on post-operation day 7 and remained high up to day 28. Mice with 2K1C-induced hypertension had impaired long-term, but not short-term, memory. Dendritic complexity of CA1 neurons and hippocampal neurogenesis were reduced by 2K1C-induced hypertension on post-operation day 28. Furthermore, 2K1C decreased the levels of hippocampal brain-derived neurotrophic factor, while blood vessel density and activation status of astrocytes and microglia were not affected. In conclusion, hypertension impairs hippocampus-associated long-term memory, dendritic arborization and neurogenesis, which may be caused by down-regulation of brain-derived neurotrophic factor signaling pathways. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

The derivative expansion of the fermion number current

International Nuclear Information System (INIS)

D'Hoker, E.; Goldstone, J.

1985-01-01

The fermion number current is evaluated to leading order in the derivative expansion for chiral fermions in the background of arbitrary Higgs and chiral gauge fields. This current is given by the gauged topological current plus a total divergence term. The total divergence term is absent in Weinberg-Salam theory with one scalar Higgs doublet, even for an arbitrary mass matrix, but appears when several Higgs doublets are present. (orig.)

17 CFR 240.3b-12 - Definition of OTC derivatives dealer.

Science.gov (United States)

2010-04-01

... to options, forwards, futures, swap agreements, or collars involving currencies, interest or other... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definition of OTC derivatives... Securities Exchange Act of 1934 Definitions § 240.3b-12 Definition of OTC derivatives dealer. The term OTC...

Association study of a brain-derived neurotrophic factor polymorphism and short-term antidepressant response in major depressive disorders

Directory of Open Access Journals (Sweden)

Lung-Cheng Huang

2008-10-01

Full Text Available Eugene Lin1,7, Po See Chen2,6,7, Lung-Cheng Huang3,4, Sen-Yen Hsu51Vita Genomics, Inc., Wugu Shiang, Taipei, Taiwan; 2Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Department of Psychiatry, National Taiwan University Hospital Yun-Lin Branch, Taiwan; 4Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Psychiatry, Chi Mei Medical Center, Liouying, Tainan, Taiwan; 6Department of Psychiatry, National Cheng Kung University Hospital, Dou-liou Branch, Yunlin, Taiwan; 7These authors contributed equally to this workAbstract: Major depressive disorder (MDD is one of the most common mental disorders worldwide. Single nucleotide polymorphisms (SNPs can be used in clinical association studies to determine the contribution of genes to drug efficacy. A common SNP in the brain-derived neurotrophic factor (BDNF gene, a methionine (Met substitution for valine (Val at codon 66 (Val66Met, is a candidate SNP for influencing antidepressant treatment outcome. In this study, our goal was to determine the relationship between the Val66Met polymorphism in the BDNF gene and the rapid antidepressant response to venlafaxine in a Taiwanese population with MDD. Overall, the BDNF Val66Met polymorphism was found not to be associated with short-term venlafaxine treatment outcome. However, the BDNF Val66Met polymorphism showed a trend to be associated with rapid venlafaxine treatment response in female patients. Future research with independent replication in large sample sizes is needed to confirm the role of the BDNF Val66Met polymorphism identified in this study.Keywords: antidepressant response, brain-derived neurotrophic factor, major depressive disorder, serotonin and norepinephrine reuptake inhibitor, single nucleotide polymorphisms

Deriving GENERIC from a generalized fluctuation symmetry

NARCIS (Netherlands)

Kraaij, R.; Lazarescu, A.; Maes, C.; Peletier, M.A.

2018-01-01

Much of the structure of macroscopic evolution equations for relaxation to equilibrium can be derived from symmetries in the dynamical fluctuations around the most typical trajectory. For example, detailed balance as expressed in terms of the Lagrangian for the path-space action leads to gradient

Meshable: searching PubMed abstracts by utilizing MeSH and MeSH-derived topical terms.

Science.gov (United States)

Kim, Sun; Yeganova, Lana; Wilbur, W John

2016-10-01

Medical Subject Headings (MeSH(®)) is a controlled vocabulary for indexing and searching biomedical literature. MeSH terms and subheadings are organized in a hierarchical structure and are used to indicate the topics of an article. Biologists can use either MeSH terms as queries or the MeSH interface provided in PubMed(®) for searching PubMed abstracts. However, these are rarely used, and there is no convenient way to link standardized MeSH terms to user queries. Here, we introduce a web interface which allows users to enter queries to find MeSH terms closely related to the queries. Our method relies on co-occurrence of text words and MeSH terms to find keywords that are related to each MeSH term. A query is then matched with the keywords for MeSH terms, and candidate MeSH terms are ranked based on their relatedness to the query. The experimental results show that our method achieves the best performance among several term extraction approaches in terms of topic coherence. Moreover, the interface can be effectively used to find full names of abbreviations and to disambiguate user queries. https://www.ncbi.nlm.nih.gov/IRET/MESHABLE/ CONTACT: sun.kim@nih.gov Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Critical Phenomena in Higher Curvature Charged AdS Black Holes

Directory of Open Access Journals (Sweden)

Arindam Lala

2013-01-01

Full Text Available In this paper, we have studied the critical phenomena in higher curvature charged AdS black holes. We have considered Lovelock-Born-Infeld-AdS black hole as an example. The thermodynamics of the black hole have been studied which reveals the onset of a higher-order phase transition in the black hole in the canonical ensemble (fixed charge ensemble framework. We have analytically derived the critical exponents associated with these thermodynamic quantities. We find that our results fit well with the thermodynamic scaling laws and consistent with the mean field theory approximation. The suggestive values of the other two critical exponents associated with the correlation function and correlation length on the critical surface have been derived.

THE FUNDAMENTAL SOLUTIONS FOR MULTI-TERM MODIFIED POWER LAW WAVE EQUATIONS IN A FINITE DOMAIN.

Science.gov (United States)

Jiang, H; Liu, F; Meerschaert, M M; McGough, R J

2013-01-01

Fractional partial differential equations with more than one fractional derivative term in time, such as the Szabo wave equation, or the power law wave equation, describe important physical phenomena. However, studies of these multi-term time-space or time fractional wave equations are still under development. In this paper, multi-term modified power law wave equations in a finite domain are considered. The multi-term time fractional derivatives are defined in the Caputo sense, whose orders belong to the intervals (1, 2], [2, 3), [2, 4) or (0, n ) ( n > 2), respectively. Analytical solutions of the multi-term modified power law wave equations are derived. These new techniques are based on Luchko's Theorem, a spectral representation of the Laplacian operator, a method of separating variables and fractional derivative techniques. Then these general methods are applied to the special cases of the Szabo wave equation and the power law wave equation. These methods and techniques can also be extended to other kinds of the multi-term time-space fractional models including fractional Laplacian.

The uranium industry: long-term planning for short-term competition

International Nuclear Information System (INIS)

Vottero, X.; Georges Capus, G.

2001-01-01

Long term planning for short term competition Today, uranium producers face new challenges in terms of both production (new regulatory, environmental and social constraints) and market conditions (new sources of uranium supply, very low prices and tough competition). In such a context, long-term planning is not just a prerequisite to survive in the nuclear fuel cycle industry. In fact, it also contributes to sustaining nuclear electricity generation facing fierce competition from other energy sources in increasingly deregulated markets. Firstly, the risk of investing in new mining projects in western countries is growing because, on the one hand, of very erratic market conditions and, on the other hand, of increasingly lengthy, complex and unpredictable regulatory conditions. Secondly, the supply of other sources of uranium (uranium derived from nuclear weapons, uranium produced in CIS countries, ...) involve other risks, mainly related to politics and commercial restrictions. Consequently, competitive uranium supply requires not only technical competence but also financial strength and good marketing capabilities in order to anticipate long-term market trends, in terms of both demand and supply. It also requires taking into account new parameters such as politics, environment, regulations, etc. Today, a supplier dedicated to the sustainable production of nuclear electricity must manage a broad range of long-term risks inherent to the procurement of uranium. Taking into account all these parameters in a context of short-term, fast-changing market is a great challenge for the future generation. World Uranium Civilian Supply and Demand. (authors)

On the exceptional generalised Lie derivative for d≥7

International Nuclear Information System (INIS)

Rosabal, J.A.

2015-01-01

In this work we revisit the E_8×ℝ"+ generalised Lie derivative encoding the algebra of diffeomorphisms and gauge transformations of compactifications of M-theory on eight-dimensional manifolds, by extending certain features of the E_7×ℝ"+ one. Compared to its E_d×ℝ"+, d≤7 counterparts, a new term is needed for consistency. However, we find that no compensating parameters need to be introduced, but rather that the new term can be written in terms of the ordinary generalised gauge parameters by means of a connection. This implies that no further degrees of freedom, beyond those of the field content of the E_8 group, are needed to have a well defined theory. We discuss the implications of the structure of the E_8×ℝ"+ generalised transformation on the construction of the d=8 generalised geometry. Finally, we suggest how to lift the generalised Lie derivative to eleven dimensions.

Group Theory and Crystal Field Theory: A Simple and Rigorous Derivation of the Spectroscopic Terms Generated by the t[subscript 2g][superscript 2] Electronic Configuration in a Strong Octahedral Field

Science.gov (United States)

Morpurgo, Simone

2007-01-01

The principles of symmetry and group theory are applied to the zero-order wavefunctions associated with the strong-field t[subscript 2g][superscript 2] configuration and their symmetry-adapted linear combinations (SALC) associated with the generated energy terms are derived. This approach will enable students to better understand the use of…

Optimal Long-Term Financial Contracting

OpenAIRE

Peter M. DeMarzo; Michael J. Fishman

2007-01-01

We develop an agency model of financial contracting. We derive long-term debt, a line of credit, and equity as optimal securities, capturing the debt coupon and maturity; the interest rate and limits on the credit line; inside versus outside equity; dividend policy; and capital structure dynamics. The optimal debt-equity ratio is history dependent, but debt and credit line terms are independent of the amount financed and, in some cases, the severity of the agency problem. In our model, the ag...

SM2RAIN-CCI: a new global long-term rainfall data set derived from ESA CCI soil moisture

Science.gov (United States)

Ciabatta, Luca; Massari, Christian; Brocca, Luca; Gruber, Alexander; Reimer, Christoph; Hahn, Sebastian; Paulik, Christoph; Dorigo, Wouter; Kidd, Richard; Wagner, Wolfgang

2018-02-01

Accurate and long-term rainfall estimates are the main inputs for several applications, from crop modeling to climate analysis. In this study, we present a new rainfall data set (SM2RAIN-CCI) obtained from the inversion of the satellite soil moisture (SM) observations derived from the ESA Climate Change Initiative (CCI) via SM2RAIN (Brocca et al., 2014). Daily rainfall estimates are generated for an 18-year long period (1998-2015), with a spatial sampling of 0.25° on a global scale, and are based on the integration of the ACTIVE and the PASSIVE ESA CCI SM data sets.The quality of the SM2RAIN-CCI rainfall data set is evaluated by comparing it with two state-of-the-art rainfall satellite products, i.e. the Tropical Measurement Mission Multi-satellite Precipitation Analysis 3B42 real-time product (TMPA 3B42RT) and the Climate Prediction Center Morphing Technique (CMORPH), and one modeled data set (ERA-Interim). A quality check is carried out on a global scale at 1° of spatial sampling and 5 days of temporal sampling by comparing these products with the gauge-based Global Precipitation Climatology Centre Full Data Daily (GPCC-FDD) product. SM2RAIN-CCI shows relatively good results in terms of correlation coefficient (median value > 0.56), root mean square difference (RMSD, median value test the capabilities of the data set to correctly identify rainfall events under different climate and precipitation regimes.The SM2RAIN-CCI rainfall data set is freely available at https://doi.org/10.5281/zenodo.846259.

Partially-massless higher-spin algebras and their finite-dimensional truncations

International Nuclear Information System (INIS)

Joung, Euihun; Mkrtchyan, Karapet

2016-01-01

The global symmetry algebras of partially-massless (PM) higher-spin (HS) fields in (A)dS d+1 are studied. The algebras involving PM generators up to depth 2 (ℓ−1) are defined as the maximal symmetries of free conformal scalar field with 2 ℓ order wave equation in d dimensions. We review the construction of these algebras by quotienting certain ideals in the universal enveloping algebra of (A)dS d+1 isometries. We discuss another description in terms of Howe duality and derive the formula for computing trace in these algebras. This enables us to explicitly calculate the bilinear form for this one-parameter family of algebras. In particular, the bilinear form shows the appearance of additional ideal for any non-negative integer values of ℓ−d/2 , which coincides with the annihilator of the one-row ℓ-box Young diagram representation of so d+2 . Hence, the corresponding finite-dimensional coset algebra spanned by massless and PM generators is equivalent to the symmetries of this representation.

Computation of Mie derivatives.

Science.gov (United States)

Li, Yang; Bowler, Nicola

2013-07-10

Analytical expressions are obtained for the derivatives of Mie scattering coefficients with respect to the electrical radius of the spherical scattering particle, and to the relative permittivity and permeability of both the particle and the surrounding medium. Their corresponding approximate expressions are developed to avoid numerical overflow based on the logarithmic derivative of Riccati-Bessel functions. The analytical expressions have been verified by comparing their results with those calculated by analytical expressions developed by Mathematica. Compared with the numerical derivative, the analytical expressions and approximate expressions show a higher accuracy and are 2.0 and 2.8 times, respectively, faster in the case of a single magnetodielectric sphere. Generally, for spheres with an electrical radius in a large range, the approximate expressions can yield acceptable accuracy and computation time up to a high order. This work can be used in the design of nonmetallic metamaterials, and in the retrieval of aerosol properties from remote sensing data. An example calculation is given for the design of an optical, all-dielectric, mu-negative metamaterial consisting of a simple cubic array of tellurium nanoparticles.

Multifunctional Cinnamic Acid Derivatives

Directory of Open Access Journals (Sweden)

Aikaterini Peperidou

2017-07-01

Full Text Available Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propranolol showed the highest lipoxygenase (LOX inhibition (IC50 = 6 μΜ and antiproteolytic activity (IC50 = 0.425 μΜ. The conjugate 1a of simple cinnamic acid with propranolol showed the higher antiproteolytic activity (IC50 = 0.315 μΜ and good LOX inhibitory activity (IC50 = 66 μΜ. Compounds 3a and 3b, derived from methoxylated caffeic acid present a promising combination of in vitro inhibitory and antioxidative activities. The S isomer of 2b also presented an interesting multitarget biological profile in vitro. Molecular docking studies point to the fact that the theoretical results for LOX-inhibitor binding are identical to those from preliminary in vitro study.

N-cadherin{sup +} HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin{sup -} HSCs

Energy Technology Data Exchange (ETDEWEB)

Toyama, Hirofumi; Arai, Fumio; Hosokawa, Kentaro; Ikushima, Yoshiko Matsumoto [Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan); Suda, Toshio, E-mail: sudato@z3.keio.jp [Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582 (Japan)

2012-11-23

Highlights: Black-Right-Pointing-Pointer High N-cad expression was detected in E12.5 mouse FL LT-HSCs (EPCR{sup +} LSK cells). Black-Right-Pointing-Pointer Immunohistochemically, N-cad{sup +} HSCs co-localized with sinusoidal ECs (Lyve-1{sup +} cells) in E12.5 FL, but these gradually detached in E15.5 and E18.5 FL. Black-Right-Pointing-Pointer N-cad{sup +} LSK cells in E12.5 FL exhibited higher LTR activity versus N-cad{sup -} LSK cells, which decreased in E15.5 and E18.5. Black-Right-Pointing-Pointer N-cad expression may confer high LTR activity to HSCs by facilitating interactions with the perisinusoidal niche in FL. -- Abstract: Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment known as the stem cell niche. The regulation of HSCs in fetal liver (FL) and their niche, however, remains to be elucidated. In this study, we investigated the role of N-cadherin (N-cad) in the maintenance of HSCs during FL hematopoiesis. By using anti-N-cad antibodies (Abs) produced by our laboratory, we detected high N-cad expression in embryonic day 12.5 (E12.5) mouse FL HSCs, but not in E15.5 and E18.5 FL. Immunofluorescence staining revealed that N-cad{sup +}c-Kit{sup +} and N-cad{sup +} endothelial protein C receptor (EPCR){sup +} HSCs co-localized with Lyve-1{sup +} sinusoidal endothelial cells (ECs) in E12.5 FL and that some of these cells also expressed N-cad. However, N-cad{sup +} HSCs were also observed to detach from the perisinusoidal niche at E15.5 and E18.5, concomitant with a down-regulation of N-cad and an up-regulation of E-cadherin (E-cad) in hepatic cells. Moreover, EPCR{sup +} long-term (LT)-HSCs were enriched in the N-cad{sup +}Lin{sup -}Sca-1{sup +}c-Kit{sup +} (LSK) fraction in E12.5 FL, but not in E15.5 or E18.5 FL. In a long-term reconstitution (LTR) activity assay, higher engraftment associated with N-cad{sup +} LSK cells versus N-cad{sup -} LSK cells in E12.5 FL when transplanted into lethally irradiated recipient mice. However, the

Contrasting Modern and 10Be- derived erosion rates for the Southern Betic Cordillera, Spain

Science.gov (United States)

Bellin, N.; Vanacker, V.; Kubik, P.

2012-04-01

In Europe, Southeast Spain was identified as one of the regions with major treat of desertification in the context of future land use and climate change. During the last years, significant progress has been made to understand spatial patterns of modern erosion rates in these semi-arid degraded environments. Numerous European projects have contributed to the collection of modern erosion data at different spatial scales for Southeast Spain. However, these data are rarely analysed in the context of long-term changes in vegetation, climate and human occupation. In this paper, we present Modern and Holocene denudation rates for small river basins (1 to 10 km2) located in the Spanish Betic Cordillera. Long-term erosion data were derived from cosmogenic nuclide analyses of river-borne sediment. Modern erosion data were quantified through analysis of sediment deposition volumes behind check dams, and represent average erosion rates over the last 10 to 40 years. Modern erosion rates are surprisingly low (mean erosion rate = 0.048 mm y-1; n=36). They indicate that the steep, sparsely vegetated hillslopes in the Betic Cordillera cannot directly be associated with high erosion rates. 10Be -derived erosion rates integrate over the last 37500 to 3500 years, and are roughly of the same magnitude. They range from 0.013 to 0.243 mm y-1 (mean denudation rate = 0.062 mm y-1 ± 0.054; n=20). Our data suggest that the modern erosion rates are similar to the long-term erosion rates in this area. This result is in contrast with the numerous reports on human-accelerated modern erosion rates for Southeast Spain. Interestingly, our new data on long-term erosion rates show a clear spatial pattern, with higher erosion rates in the Sierra Cabrera and lower erosion rates in Sierra de las Estancias, and Sierra Torrecilla. Preliminary geomorphometric analyses suggest that the spatial variation that we observe in long-term erosion rates is related to the gradient in uplift rates of the Betic

Derivation of the electric dipole--dipole interaction as an electric hyperfine interaction

International Nuclear Information System (INIS)

Parker, G.W.

1986-01-01

The electric dipole--dipole interaction is derived by assuming that the electron and proton in hydrogen have intrinsic electric dipole moments that interact to give an electric hyperfine interaction. The electric field at the proton due to the electron's presumed dipole moment then gives rise to a contact type term for l = 0 and the normal dipole--dipole term for lnot =0. When combined with our previous derivation of the magnetic hyperfine interaction [Am. J. Phys. 52, 36 (1984)], which used a similar approach, these derivations provide a unified treatment of the interaction of electric and magnetic dipoles. As an application of these results, the product of the electron's and proton's dipole moments is estimated to be less than 10 -29 e 2 cm 2

On the conformal higher spin unfolded equation for a three-dimensional self-interacting scalar field

Energy Technology Data Exchange (ETDEWEB)

Nilsson, Bengt E.W. [Fundamental Physics, Chalmers University of Technology,SE-412 96 Göteborg (Sweden)

2016-08-24

We propose field equations for the conformal higher spin system in three dimensions coupled to a conformal scalar field with a sixth order potential. Both the higher spin equation and the unfolded equation for the scalar field have source terms and are based on a conformal higher spin algebra which we treat as an expansion in multi-commutators. Explicit expressions for the source terms are suggested and subjected to some simple tests. We also discuss a cascading relation between the Chern-Simons action for the higher spin gauge theory and an action containing a term for each spin that generalizes the spin 2 Chern-Simons action in terms of the spin connection expressed in terms of the frame field. This cascading property is demonstrated in the free theory for spin 3 but should work also in the complete higher spin theory.

On a quantum version of conservation laws for derivative nonlinear Schrodinger equation

International Nuclear Information System (INIS)

Sen, S.; Chowdhury, A.R.

1988-01-01

The authors derived the quantum mechanical versions of infinite number of conservation laws associated with Derivative Nonlinear Schrodinger equation with the help of a methodology used in string theory. The renormalised version of the conserved quantities are obtained with explicit forms of the counter terms

Capacitance, charge dynamics, and electrolyte-surface interactions in functionalized carbide-derived carbon electrodes

Directory of Open Access Journals (Sweden)

Boris Dyatkin

2015-12-01

Full Text Available This study analyzed the dynamics of ionic liquid electrolyte inside of defunctionalized, hydrogenated, and aminated pores of carbide-derived carbon supercapacitor electrodes. The approach tailors surface functionalities and tunes nanoporous structures to decouple the influence of pore wall composition on capacitance, ionic resistance, and long-term cyclability. Quasi-elastic neutron scattering probes the self-diffusion properties and electrode-ion interactions of electrolyte molecules confined in functionalized pores. Room-temperature ionic liquid interactions in confined pores are strongest when the hydrogen-containing groups are present on the surface. This property translates into higher capacitance and greater ion transport through pores during electrochemical cycling. Unlike hydrogenated pores, aminated pores do not favorably interact with ionic liquid ions and, subsequently, are outperformed by defunctionalized surfaces.

Capacitance, charge dynamics, and electrolyte-surface interactions in functionalized carbide-derived carbon electrodes

Energy Technology Data Exchange (ETDEWEB)

Dyatkin, Boris; Mamontov, Eugene; Cook, Kevin M.; Gogotsi, Yury

2015-12-01

This study analyzed the dynamics of ionic liquid electrolyte inside of defunctionalized, hydrogenated, and aminated pores of carbide-derived carbon supercapacitor electrodes. The approach tailors surface functionalities and tunes nanoporous structures to decouple the influence of pore wall composition on capacitance, ionic resistance, and long-term cyclability. Quasi-elastic neutron scattering probes the self-diffusion properties and electrode-ion interactions of electrolyte molecules confined in functionalized pores. Room-temperature ionic liquid interactions in confined pores are strongest when the hydrogen-containing groups are present on the surface. This property translates into higher capacitance and greater ion transport through pores during electrochemical cycling. Unlike hydrogenated pores, aminated pores do not favorably interact with ionic liquid ions and, subsequently, are outperformed by defunctionalized surfaces.

Deriving GENERIC from a Generalized Fluctuation Symmetry

Science.gov (United States)

Kraaij, Richard; Lazarescu, Alexandre; Maes, Christian; Peletier, Mark

2018-02-01

Much of the structure of macroscopic evolution equations for relaxation to equilibrium can be derived from symmetries in the dynamical fluctuations around the most typical trajectory. For example, detailed balance as expressed in terms of the Lagrangian for the path-space action leads to gradient zero-cost flow. We expose a new such fluctuation symmetry that implies GENERIC, an extension of gradient flow where a Hamiltonian part is added to the dissipative term in such a way as to retain the free energy as Lyapunov function.

Higher twist contributions to deep-inelastic structure functions

International Nuclear Information System (INIS)

Bluemlein, J.; Boettcher, H.

2008-07-01

We report on a recent extraction of the higher twist contributions to the deep inelastic structure functions F ep,ed 2 (x,Q 2 ) in the large x region. It is shown that the size of the extracted higher twist contributions is strongly correlated with the higher order corrections applied to the leading twist part. A gradual lowering of the higher twist contributions going from NLO to N 4 LO is observed, where in the latter case only the leading large x terms were considered. (orig.)

Spinning particle approach to higher spin field theory

International Nuclear Information System (INIS)

Corradini, Olindo

2011-01-01

We shortly review on the connection between higher-spin gauge field theories and supersymmetric spinning particle models. In such approach the higher spin equations of motion are linked to the first-class constraint algebra associated with the quantization of particle models. Here we consider a class of spinning particle models characterized by local O(N)-extended supersymmetry since these models are known to provide an alternative approach to the geometric formulation of higher spin field theory. We describe the canonical quantization of the models in curved target space and discuss the obstructions that appear in presence of an arbitrarily curved background. We then point out the special role that conformally flat spaces appear to have in such models and present a derivation of the higher-spin curvatures for maximally symmetric spaces.

Highly stable rice-straw-derived charcoal in 3700-year-old ancient paddy soil: evidence for an effective pathway toward carbon sequestration.

Science.gov (United States)

Wu, Mengxiong; Yang, Min; Han, Xingguo; Zhong, Ting; Zheng, Yunfei; Ding, Pin; Wu, Weixiang

2016-01-01

Recalcitrant charcoal application is predicted to decelerate global warming through creating a long-term carbon sink in soil. Although many studies have showed high stability of charcoal derived from woody materials, few have focused on the dynamics of straw-derived charcoal in natural environment on a long timescale to evaluate its potential for agricultural carbon sequestration. Here, we examined straw-derived charcoal in an ancient paddy soil dated from ~3700 calendar year before present (cal. year BP). Analytical results showed that soil organic matter consisted of more than 25% of charcoal in charcoal-rich layer. Similarities in morphology and molecular structure between the ancient and the fresh rice-straw-derived charcoal indicated that ancient charcoal was derived from rice straw. The lower carbon content, higher oxygen content, and obvious carbonyl of the ancient charcoal compared with fresh rice straw charcoal implied that oxidation occurred in the scale of thousands years. However, the dominant aromatic C of ancient charcoal indicated that rice-straw-derived charcoal was highly stable in the buried paddy soil due to its intrinsic chemical structures and the physical protection of ancient paddy wetland. Therefore, it may suggest that straw charcoal application is a potential pathway for C sequestration considering its longevity.

Supplementing an energy adequate, higher protein diet with protein does not enhance fat-free mass restoration after short-term severe negative energy balance.

Science.gov (United States)

Berryman, C E; Sepowitz, J J; McClung, H L; Lieberman, H R; Farina, E K; McClung, J P; Ferrando, A A; Pasiakos, S M

2017-06-01

Negative energy balance during military operations can be severe and result in significant reductions in fat-free mass (FFM). Consuming supplemental high-quality protein following such military operations may accelerate restoration of FFM. Body composition (dual-energy X-ray absorptiometry) and whole body protein turnover (single-pool [ 15 N]alanine method) were determined before (PRE) and after 7 days (POST) of severe negative energy balance during military training in 63 male US Marines (means ± SD, 25 ± 3 yr, 84 ± 9 kg). After POST measures were collected, volunteers were randomized to receive higher protein (HIGH: 1,103 kcal/day, 133 g protein/day), moderate protein (MOD: 974 kcal/day, 84 g protein/day), or carbohydrate-based low protein control (CON: 1,042 kcal/day, 7 g protein/day) supplements, in addition to a self-selected, ad libitum diet, for the 27-day intervention (REFED). Measurements were repeated POST-REFED. POST total body mass (TBM; -5.8 ± 1.0 kg, -7.0%), FFM (-3.1 ± 1.6 kg, -4.7%), and net protein balance (-1.7 ± 1.1 g protein·kg -1 ·day -1 ) were lower and proteolysis (1.1 ± 1.9 g protein·kg -1 ·day -1 ) was higher compared with PRE ( P energy (4,498 ± 725 kcal/day). All volunteers, independent of group assignment, achieved positive net protein balance (0.4 ± 1.0 g protein·kg -1 ·day -1 ) and gained TBM (5.9 ± 1.7 kg, 7.8%) and FFM (3.6 ± 1.8 kg, 5.7%) POST-REFED compared with POST ( P energy-adequate, higher protein diets with additional protein may not be necessary to restore FFM after short-term severe negative energy balance. NEW & NOTEWORTHY This article demonstrates 1 ) the majority of physiological decrements incurred during military training (e.g., total and fat-free mass loss), with the exception of net protein balance, resolve and return to pretraining values after 27 days and 2 ) protein supplementation, in addition to an ad libitum, higher protein (~2.0 g·kg -1 ·day -1 ), energy adequate diet, is not necessary to

Molecular Docking Study on Galantamine Derivatives as Cholinesterase Inhibitors.

Science.gov (United States)

Atanasova, Mariyana; Yordanov, Nikola; Dimitrov, Ivan; Berkov, Strahil; Doytchinova, Irini

2015-06-01

A training set of 22 synthetic galantamine derivatives binding to acetylcholinesterase was docked by GOLD and the protocol was optimized in terms of scoring function, rigidity/flexibility of the binding site, presence/absence of a water molecule inside and radius of the binding site. A moderate correlation was found between the affinities of compounds expressed as pIC50 values and their docking scores. The optimized docking protocol was validated by an external test set of 11 natural galantamine derivatives and the correlation coefficient between the docking scores and the pIC50 values was 0.800. The derived relationship was used to analyze the interactions between galantamine derivatives and AChE. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Higher Education and Peacebuilding--A Bridge between Communities?

Science.gov (United States)

Rasheed, Rebeen A.; Munoz, Alexander

2016-01-01

As the Syrian civil war enters its fifth year, with over four million refugees and no solution in the near future, the international community must better consider long-term planning in regards to the plight of refugees and services to support them, not just short-term emergency responses. Critically, higher education is all too often ignored when…

Differential invariants for higher-rank tensors. A progress report

International Nuclear Information System (INIS)

Tapial, V.

2004-07-01

We outline the construction of differential invariants for higher-rank tensors. In section 2 we outline the general method for the construction of differential invariants. A first result is that the simplest tensor differential invariant contains derivatives of the same order as the rank of the tensor. In section 3 we review the construction for the first-rank tensors (vectors) and second-rank tensors (metrics). In section 4 we outline the same construction for higher-rank tensors. (author)

Derivation of Hamiltonians for accelerators

Energy Technology Data Exchange (ETDEWEB)

Symon, K.R.

1997-09-12

In this report various forms of the Hamiltonian for particle motion in an accelerator will be derived. Except where noted, the treatment will apply generally to linear and circular accelerators, storage rings, and beamlines. The generic term accelerator will be used to refer to any of these devices. The author will use the usual accelerator coordinate system, which will be introduced first, along with a list of handy formulas. He then starts from the general Hamiltonian for a particle in an electromagnetic field, using the accelerator coordinate system, with time t as independent variable. He switches to a form more convenient for most purposes using the distance s along the reference orbit as independent variable. In section 2, formulas will be derived for the vector potentials that describe the various lattice components. In sections 3, 4, and 5, special forms of the Hamiltonian will be derived for transverse horizontal and vertical motion, for longitudinal motion, and for synchrobetatron coupling of horizontal and longitudinal motions. Hamiltonians will be expanded to fourth order in the variables.

Sorption of ammonium and phosphate from aqueous solution by biochar derived from phytoremediation plants

Institute of Scientific and Technical Information of China (English)

Zheng ZENG; Muhammad Tariq RAFIQ; Song-da ZHANG; Ting-qiang LI; Feng-liang ZHAO; Zhen-li HE; He-ping ZHAO; Xiao-e YANG; Hai-long WANG; Jing ZHAO

2013-01-01

The study on biochar derived from plant biomass for environmental applications is attracting more and more attention. Twelve sets of biochar were obtained by treating four phytoremediation plants, Salix rosthorni Seemen, Thalia dealbata, Vetiveria zizanioides, and Phragmites sp., sequential y through pyrolysis at 500 °C in a N2 environ-ment, and under different temperatures (500, 600, and 700 °C) in a CO2 environment. The cation exchange capacity and specific surface area of biochar varied with both plant species and pyrolysis temperature. The magnesium (Mg) content of biochar derived from T. dealbata (TC) was obviously higher than that of the other plant biochars. This bi-ochar also had the highest sorption capacity for phosphate and ammonium. In terms of biomass yields, adsorption capacity, and energy cost, T. dealbata biochar produced at 600 °C (TC600) is the most promising sorbent for removing contaminants (N and P) from aqueous solution. Therefore, T. dealbata appears to be the best candidate for phyto-remediation application as its biomass can make a good biochar for environmental cleaning.

Application for approval of derived authorized limits for the release of the 190-C trenches and 105-C process water tunnels at the Hanford Site: Volume 2 - source term development

International Nuclear Information System (INIS)

Denham, D.H.; Winslow, S.L.; Moeller, M.P.; Kennedy, W.E. Jr.

1997-03-01

As part of environmental restoration activities at the Hanford Site, Bechtel Hanford, Inc. is conducting a series of evaluations to determine appropriate release conditions for specific facilities following the completion of decontamination and decommissioning projects. The release conditions, with respect to the residual volumetric radioactive contamination, are termed authorized limits. This report presents the summary of the supporting information and the final application for approval of derived authorized limits for the release of the 190-C trenches and the 105-C process water tunnels. This document contains two volumes; this volume (Vol. 2) contains the radiological characterization data, spreadsheet analyses, and radiological source terms

Inflationary scenario from higher curvature warped spacetime

International Nuclear Information System (INIS)

Banerjee, Narayan; Paul, Tanmoy

2017-01-01

We consider a five dimensional warped spacetime, in presence of the higher curvature term like F(R) = R + αR 2 in the bulk, in the context of the two-brane model. Our universe is identified with the TeV scale brane and emerges as a four dimensional effective theory. From the perspective of this effective theory, we examine the possibility of ''inflationary scenario'' by considering the on-brane metric ansatz as an FRW one. Our results reveal that the higher curvature term in the five dimensional bulk spacetime generates a potential term for the radion field. Due to the presence of radion potential, the very early universe undergoes a stage of accelerated expansion and, moreover, the accelerating period of the universe terminates in a finite time. We also find the spectral index of curvature perturbation (n s ) and the tensor to scalar ratio (r) in the present context, which match with the observational results based on the observations of Planck (Astron. Astrophys. 594, A20, 2016). (orig.)

Inflationary scenario from higher curvature warped spacetime

Energy Technology Data Exchange (ETDEWEB)

Banerjee, Narayan [Indian Institute of Science Education and Research Kolkata, Department of Physical Sciences, Nadia, West Bengal (India); Paul, Tanmoy [Indian Association for the Cultivation of Science, Department of Theoretical Physics, Kolkata (India)

2017-10-15

We consider a five dimensional warped spacetime, in presence of the higher curvature term like F(R) = R + αR{sup 2} in the bulk, in the context of the two-brane model. Our universe is identified with the TeV scale brane and emerges as a four dimensional effective theory. From the perspective of this effective theory, we examine the possibility of ''inflationary scenario'' by considering the on-brane metric ansatz as an FRW one. Our results reveal that the higher curvature term in the five dimensional bulk spacetime generates a potential term for the radion field. Due to the presence of radion potential, the very early universe undergoes a stage of accelerated expansion and, moreover, the accelerating period of the universe terminates in a finite time. We also find the spectral index of curvature perturbation (n{sub s}) and the tensor to scalar ratio (r) in the present context, which match with the observational results based on the observations of Planck (Astron. Astrophys. 594, A20, 2016). (orig.)

Modelling the short term interest with stochastic differential equation in continuous time: linear versus non-linear mode

OpenAIRE

2014-01-01

M.Com. (Financial Economics) Recently, there has been a growth in the bond market. This growth has brought with it an ever-increasing volume and range of interest rate depended derivative products known as interest rate derivatives. Amongst the variables used in pricing these derivative products is the short-term interest rate. A numbers of short-term interest rate models that are used to fit the short-term interest rate exist. Therefore, understanding the features characterised by various...

Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives

Directory of Open Access Journals (Sweden)

Zhibin Li

2015-07-01

Full Text Available A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani (53.35% than commercial antiviral agent validamycin (36.4%; compound F16 exhibited high fungicidal activity against Oospora citriaurantii ex Persoon (43.28%. Some of the alkaloids and their derivatives (compounds F4 and F25 exhibited broad-spectrum fungicidal activity. Specifically, compound F4 exhibited excellent high broad-spectrum fungicidal activity in vitro, and the curative and protection activities against P. litchi in vivo reached 92.59% and 59.26%, respectively. The new derivative, F4, with optimized physicochemical properties, obviously exhibited higher activities both in vitro and in vivo; therefore, F4 may be used as a new lead structure for the development of fungicidal drugs.

Teaching Evaluation Is Very Necessary at Institutions of Higher Education

Science.gov (United States)

Daren, Huang

2009-01-01

Government supervision over the quality of higher education by means of evaluations, examinations and verifications, or accreditations is a common international practice in terms of monitoring and controlling the quality of higher education. Many countries stipulate by law that institutions of higher education must submit to evaluation by the…

Chiral anomalies in higher dimensional supersymmetric theories

International Nuclear Information System (INIS)

Bonora, L.; Pasti, P.; Tonin, M.

1987-01-01

We derive explicit formulas for pure gauge anomalies in a SYM theory in 6D as well as in 10D. Each anomaly consists of two terms: a gauge cocycle and a cocycle of the superdiffeomorphisms. The derivation is based essentially on a remarkable property of supersymmetric theories which we call Weil triviality and is directly connected with the constraints. The analogous problem for Lorentz anomalies is stated in the same way. However, in general, there are difficulties concerning Weil triviality. We prove that for pure SUGRA in 6D as well as in 10D it is possible to prove Weil triviality and, consequently, to obtain explict expressions for pure Lorentz anomalies. However, as far as SUGRA coupled to SYM a la Chapline-Manton or a la Green-Schwarz is concerned, no self-evident solution is available. (orig.)

New diarylmethanofullerene derivatives and their properties for organic thin-film solar cells

Directory of Open Access Journals (Sweden)

Daisuke Sukeguchi

2009-02-01

Full Text Available A number of diarylmethanofullerene derivatives were synthesized. The cyclopropane ring of the derivatives has two aryl groups substituted with electron-withdrawing and -donating groups, the latter with long alkyl chains to improve solubility in organic solvents, an important property in processing cells. First reduction potentials of most derivatives were less negative than that of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM, which is possibly ascribed to their electron-withdrawing nature. Organic thin-film photovoltaic cells fabricated with poly(3-hexylthiophene (P3HT as the electron-donor and diarylmethanofullerene derivatives as the electron-acceptor material were examined. The {(methoxycarbonylphenyl[bis(octyloxyphenyl]methano}fullerene showed power conversion efficiency as high as PCBM, but had higher solubility in a variety of organic solvents than PCBM. The Voc value was higher than that of PCBM, which is derived from the electron-donating (octyloxyphenyl group, possibly raising the LUMO level. Photovoltaic effects of the devices fabricated with the derivatives having some electron-withdrawing groups were also examined.

Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V

Directory of Open Access Journals (Sweden)

Wenjun Wu

2011-12-01

Full Text Available In order to develop new biorational pesticides, ten new 6-substituted ester derivatives of Celangulin-V were designed and synthesized. The structures of the new derivatives were confirmed by IR, 1H-NMR, 13C-NMR and ESI-MS spectral analysis. Insecticidal activities of these compounds were tested against the third-instar larvae of Mythimna separata. Two derivatives (1.1, 1.2 showed higher insecticidal activities than Celangulin-V, with mortality of 75.0% and 83.3%, respectively. While four compounds (1.3, 1.4, 1.7, 1.8 denoted lower insecticidal activities, the others (1.5, 1.6, 1.9, 1.10 revealed no activities at a concentration of 10 mg.mL−1. The results suggest that C-6 substitutions of Celangulin-V are very important in determining the insecticidal activities of its ester-derivatives. That the acetyl (1.1 and propionyl (1.2 derivatives possessed much higher insecticidal activities than Celangulin-V itself supported the view that Celangulin-V has the potential to be a lead structure of semi-synthetic green insecticides.

Anterior cruciate ligament-derived cells have high chondrogenic potential.

Science.gov (United States)

Furumatsu, Takayuki; Hachioji, Motomi; Saiga, Kenta; Takata, Naoki; Yokoyama, Yusuke; Ozaki, Toshifumi

2010-01-01

Anterior cruciate ligament (ACL)-derived cells have a character different from medial collateral ligament (MCL)-derived cells. However, the critical difference between ACL and MCL is still unclear in their healing potential and cellular response. The objective of this study was to investigate the mesenchymal differentiation property of each ligament-derived cell. Both ligament-derived cells differentiated into adipogenic, osteogenic, and chondrogenic lineages. In chondrogenesis, ACL-derived cells had the higher chondrogenic property than MCL-derived cells. The chondrogenic marker genes, Sox9 and alpha1(II) collagen (Col2a1), were induced faster in ACL-derived pellets than in MCL-derived pellets. Sox9 expression preceded the increase of Col2a1 in both pellet-cultured cells. However, the expression level of Sox9 and a ligament/tendon transcription factor Scleraxis did not parallel the increase of Col2a1 expression along with chondrogenic induction. The present study demonstrates that the balance between Sox9 and Scleraxis have an important role in the chondrogenic differentiation of ligament-derived cells. Copyright 2009 Elsevier Inc. All rights reserved.

How Will English Higher Education Look Like in 2025?

NARCIS (Netherlands)

Huisman, Jeroen; de Boer, Harry F.; Botas, Paulo Charles Pimentel

2013-01-01

In light of the recent higher education policy changes in the UK, a scenario study was carried out – based on the Delphi-method – exploring the longer term impact (2025) of the policies on English higher education. The two scenarios are briefly presented below.

Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: data from a randomized controlled trial.

Science.gov (United States)

Ayers, Lisa; Stoewhas, Anne-Christin; Ferry, Berne; Stradling, John; Kohler, Malcolm

2013-01-01

Obstructive sleep apnea has been associated with impaired endothelial function; however, the mechanisms underlying this association are not completely understood. Cell-derived microparticles may provide a link between obstructive sleep apnea and endothelial dysfunction. This randomized controlled trial aimed to examine the effect of a 2-week withdrawal of continuous positive airway pressure (CPAP) therapy on levels of circulating microparticles. Forty-one obstructive sleep apnea patients established on CPAP treatment were randomized to either CPAP withdrawal (subtherapeutic CPAP) or continuing therapeutic CPAP, for 2 weeks. Polysomnography was performed and circulating levels of microparticles were analyzed by flow cytometry at baseline and 2 weeks. CPAP withdrawal led to a recurrence of obstructive sleep apnea. Levels of CD62E+ endothelium-derived microparticles increased significantly in the CPAP withdrawal group compared to the continuing therapeutic CPAP group (median difference in change +32.4 per µl; 95% CI +7.3 to +64.1 per µl, p = 0.010). CPAP withdrawal was not associated with a statistically significant increase in granulocyte, leukocyte, and platelet-derived microparticles when compared with therapeutic CPAP. Short-term withdrawal of CPAP therapy leads to a significant increase in endothelium-derived microparticles, suggesting that microparticle formation may be causally linked to obstructive sleep apnea and may promote endothelial activation. Copyright © 2012 S. Karger AG, Basel.

Derivation of endogenous equivalent values to support risk assessment and risk management decisions for an endogenous carcinogen: Ethylene oxide.

Science.gov (United States)

Kirman, C R; Hays, S M

2017-12-01

An approach is presented for ethylene oxide (EO) to derive endogenous equivalent (EE) values, which are endogenous levels normally found within the body expressed in terms of exogenous exposures. EE values can be used to support risk assessment and risk management decisions for chemicals such as EO that have both endogenous and exogenous exposure pathways. EE values were derived using a meta-analysis of data from the published literature characterizing the distribution for an EO biomarker of exposure, hemoglobin N-(2-hydroxyethyl)-valine (HEV), in unexposed populations. These levels are compared to the those reported in exposed populations (smokers, workers). Correlation between the biomarker of exposure and external exposures of EO were applied to this distribution to determine corresponding EE values, which range from 0.13 to 6.9 ppb for EO in air. These values are orders of magnitude higher than risk-based concentration values derived for EO using default methods, and are provided as a pragmatic, data-driven alternative approach to managing the potential risks from exogenous exposures to EO. Copyright © 2017 Elsevier Inc. All rights reserved.

Antimutagenic activity of dextran gammaphos derivatives

International Nuclear Information System (INIS)

Bakhitova, L.M.; Pashin, O.V.; Drobchenko, S.N.; Bondarev, G.I.

1991-01-01

In experiments with V-79 Chinese hamster cell culture the influence of dextran gammaphos derivatives on the mutagenic effects of γ-radiation was studied by the number of cells with micronuclei and fragmented nuclei. Products of interaction between gammaphos and dialdehyde dextran were shown to a higher antimutagenic activity than gammaphos

The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes.

Science.gov (United States)

Wen, Shu Wen; Sceneay, Jaclyn; Lima, Luize Goncalves; Wong, Christina S F; Becker, Melanie; Krumeich, Sophie; Lobb, Richard J; Castillo, Vanessa; Wong, Ke Ni; Ellis, Sarah; Parker, Belinda S; Möller, Andreas

2016-12-01

Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the tumor microenvironment. Here, we use optical imaging to determine that exogenously administered fluorescently labeled exosomes derived from highly metastatic murine breast cancer cells distributed predominantly to the lung of syngeneic mice, a frequent site of breast cancer metastasis. At the sites of accumulation, exosomes were taken up by CD45 + bone marrow-derived cells. Subsequent long-term conditioning of naïve mice with exosomes from highly metastatic breast cancer cells revealed the accumulation of myeloid-derived suppressor cells in the lung and liver. This favorable immune suppressive microenvironment was capable of promoting metastatic colonization in the lung and liver, an effect not observed from exosomes derived from nonmetastatic cells and liposome control vesicles. Furthermore, we determined that breast cancer exosomes directly suppressed T-cell proliferation and inhibited NK cell cytotoxicity, and hence likely suppressed the anticancer immune response in premetastatic organs. Together, our findings provide novel insight into the tissue-specific outcomes of breast cancer-derived exosome accumulation and their contribution to immune suppression and promotion of metastases. Cancer Res; 76(23); 6816-27. ©2016 AACR. ©2016 American Association for Cancer Research.

Studying the intervention of an unusual term in f(T) gravity via the Noether symmetry approach. On a new term for gravity actions

Energy Technology Data Exchange (ETDEWEB)

Tajahmad, Behzad [University of Tabriz, Faculty of Physics, Tabriz (Iran, Islamic Republic of)

2017-08-15

As has been done before, we study an unknown coupling function, i.e. F(φ), together with a function of torsion and also curvature, i.e. f(T) and f(R), generally depending upon a scalar field. In the f(R) case, it comes from quantum correlations and other sources. Now, what if beside this term in f(T) gravity context, we enhance the action through another term which depends upon both scalar field and its derivatives? In this paper, we have added such an unprecedented term in the generic common action of f(T) gravity such that in this new term, an unknown function of torsion has coupled with an unknown function of both scalar field and its derivatives. We explain in detail why we can append such a term. By the Noether symmetry approach, we consider its behavior and effect. We show that it does not produce an anomaly, but rather it works successfully, and numerical analysis of the exact solutions of field equations coincides with all most important observational data, particularly late-time-accelerated expansion. So, this new term may be added to the gravitational actions of f(T) gravity. (orig.)

The Accessibility of Higher Education in the Russian Regions

Science.gov (United States)

Gromov, A. D.; Platonova, D. P.; Semyonov, D. S.; Pyrova, T. L.

2017-01-01

This article provides a comparative analysis of accessibility of higher education across Russian regions in terms of the following three factors: the availability of admission opportunities; financial affordability; and geographic accessibility. The study will be of interest to government agencies in higher education at various levels, analysts…

A Comparison between Human Selected, Derived and System ...

African Journals Online (AJOL)

admpather

Using a prototype implementation of our scheme, we compare the results of human-selected, derived passwords and system generated to reveal the practical viability of our approach in terms of results achieved, ease of implementation and use. Keywords: Security, Biometric, Behavioral, Keystroke dynamics, Password.

A Comparison between Human Selected, Derived and System ...

African Journals Online (AJOL)

Using a prototype implementation of our scheme, we compare the results of human-selected, derived passwords and system generated to reveal the practical viability of our approach in terms of results achieved, ease of implementation and use. Keywords: Security, Biometric, Behavioral, Keystroke dynamics, Password ...

A numerical study of the second-order wave excitation of ship springing by a higher-order boundary element method

Directory of Open Access Journals (Sweden)

Shao Yan-Lin

2014-12-01

Full Text Available This paper presents some of the efforts by the authors towards numerical prediction of springing of ships. A time-domain Higher Order Boundary Element Method (HOBEM based on cubic shape function is first presented to solve a complete second-order problem in terms of wave steepness and ship motions in a consistent manner. In order to avoid high order derivatives on the body surfaces, e.g. mj-terms, a new formulation of the Boundary Value Problem in a body-fixed coordinate system has been proposed instead of traditional formulation in inertial coordinate system. The local steady flow effects on the unsteady waves are taken into account. Double-body flow is used as the basis flow which is an appropriate approximation for ships with moderate forward speed. This numerical model was used to estimate the complete second order wave excitation of springing of a displacement ship at constant forward speeds.

Volume higher; spot price ranges widen

International Nuclear Information System (INIS)

Anon.

1994-01-01

This article is the October 1994 uranium market summary. During this reporting period, volume on the spot concentrates market doubled. Twelve deals took place: three in the spot concentrates market, one in the medium and long-term market, four in the conversion market, and four in the enrichment market. The restricted price range widened due to higher prices at the top end of the range, while the unrestricted price range widened because of lower prices at the bottom end. Spot conversion prices were higher, and enrichment prices were unchanged

Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer.

Science.gov (United States)

Ito, Shuhei; Kai, Yuichiro; Masuda, Takaaki; Tanaka, Fumiaki; Matsumoto, Toshifumi; Kamohara, Yukio; Hayakawa, Hiroshi; Ueo, Hiroaki; Iwaguro, Hideki; Hedrick, Marc H; Mimori, Koshi; Mori, Masaki

2017-12-01

More effective methods are needed for breast reconstruction after breast-conserving surgery for breast cancer. The aim of this clinical study was to assess the perioperative and long-term outcomes of adipose-derived regenerative cell (ADRC)-enriched autologous fat grafting. Ten female patients who had undergone breast-conserving surgery and adjuvant radiotherapy for breast cancer were enrolled. An ADRC-enriched fat graft prepared from the patient's adipose tissue was implanted at the time of adipose tissue harvest. The perioperative and long-term outcomes of the grafts, which included safety, efficacy, and questionnaire-based patient satisfaction, were investigated. The mean operation time was 188 ± 30 min, and the mean duration of postoperative hospitalization was 1.2 ± 0.4 days. No serious postoperative complications were associated with the procedure. Neither recurrence nor metastatic disease was observed during the follow-up period (7.8 ± 1.5 years) after transplantation. Of 9 available patients, "more than or equal to average" satisfaction with breast appearance and overall satisfaction were reported by 6 (66.7%) and 5 (55.6%) patients, respectively. ADRC-enriched autologous fat transplantation is thus considered to be safe perioperatively, with no long-term recurrence, for patients with breast cancer treated by breast-conserving surgery, and it may be an option for breast reconstruction, even after adjuvant radiotherapy.

Human Breast Adipose-Derived Stem Cells Transfected with the Stromal Cell-Derived Factor-1 Receptor CXCR4 Exhibit Enhanced Viability in Human Autologous Free Fat Grafts

Directory of Open Access Journals (Sweden)

Fang-tian Xu

2014-11-01

analysis revealed that both types of HBASCs-treated transplants consisted predominantly of adipose tissue, unlike the control transplants, and also presented significantly less fat necrosis and fibrosis. The CXCR4-transfected HBASCs-treated transplants had a significantly higher capillary density than did the other transplants and showed GFP and CD31 double-positive cells (i.e., ASCs-derived endothelial cells. The mRNA expression of CXCR4 and SDF-1α was much higher in the CXCR4-transfected HBASCs transplants than in the other three transplants. Conclusions: Our data demonstrated that HBASCs can enhance the survival and quality of transplanted free fat tissues. Moreover, CXCR4 transfection of these HBASCs could augment this effect. Stimulation of angiogenesis and decreased fat cell apoptosis due to the recruitment of endothelial progenitor cells (EPCs and an increase in graft revascularization are potential mechanisms underlying the improved long-term survival of free fat transplants following CXCR4-transfected HBASCs treatment.

Hydrodynamical equations for spherical gravitational collapse in terms of a generalized theory of gravitation with higher derivatives

International Nuclear Information System (INIS)

Nariai, Hidekazu.

1986-06-01

In similar to Misner and Sharp's formalism in general relativity for a spherical gravitational collapse, a formalism for the spherical gravitational collapse is presented on the basis of a generalized theory of gravitation in the sense of Utiyama-DeWitt (which was later extended by Parker's school and Zel'dovich's one). The resulted formalism is somewhat similar to that developed by me in 1972 based on the scalar-tensor theory of gravity. (author)

Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression

Science.gov (United States)

Zhang, Shufang; Jiang, Yang Zi; Zhang, Wei; Chen, Longkun; Tong, Tong; Liu, Wanlu; Mu, Qin; Liu, Hua; Ji, Junfeng; Ouyang, Hong Wei

2013-01-01

Immunological response hampers the investigation of human embryonic stem cells (hESCs) or their derivates for tissue regeneration in vivo. Immunosuppression is often used after surgery, but exhibits side effects of significant weight loss and allows only short-term observation. The purpose of this study was to investigate whether neonatal desensitization supports relative long-term survival of hESC-derived mesenchymal stem cells (hESC-MSCs) and promotes cartilage regeneration. hESC-MSCs were injected on the day of birth in rats. Six weeks after neonatal injection, a full-thickness cylindrical cartilage defect was created and transplanted with a hESC-MSC-seeded collagen bilayer scaffold (group d+s+c) or a collagen bilayer scaffold (group d+s). Rats without neonatal injection were transplanted with the hESC-MSC-seeded collagen bilayer scaffold to serve as controls (group s+c). Cartilage regeneration was evaluated by histological analysis, immunohistochemical staining, and biomechanical test. The role of hESC-MSCs in cartilage regeneration was analyzed by CD4 immunostaining, cell death detection, and visualization of human cells in regenerated tissues. hESC-MSCs expressed CD105, CD73, CD90, CD29, and CD44, but not CD45 and CD34, and possessed trilineage differentiation potential. Group d+s+c exhibited greater International Cartilage Repair Society (ICRS) scores than group d+s or group s+c. Abundant collagen type II and improved mechanical properties were detected in group d+s+c. There were less CD4+ inflammatory cell infiltration and cell death at week 1, and hESC-MSCs were found to survive as long as 8 weeks after transplantation in group d+s+c. Our study suggests that neonatal desensitization before transplantation may be an efficient way to develop a powerful tool for preclinical study of human cell-based therapies in animal models. PMID:22788986

Modelling long-term oil price and extraction with a Hubbert approach: The LOPEX model

International Nuclear Information System (INIS)

Rehrl, Tobias; Friedrich, Rainer

2006-01-01

The LOPEX (Long-term Oil Price and EXtraction) model generates long-term scenarios about future world oil supply and corresponding price paths up to the year 2100. In order to determine oil production in non-OPEC countries, the model uses Hubbert curves. Hubbert curves reflect the logistic nature of the discovery process and the associated constraint on temporal availability of oil. Extraction paths and world oil price path are both derived endogenously from OPEC's intertemporally optimal cartel behaviour. Thereby OPEC is faced with both the price-dependent production of the non-OPEC competitive fringe and the price-dependent world oil demand. World oil demand is modelled with a constant price elasticity function and refers to a scenario from ACROPOLIS-POLES. LOPEX results indicate a significant higher oil price from around 2020 onwards compared to the reference scenario, and a stagnating market share of maximal 50% to be optimal for OPEC

Pricing American Asian options with higher moments in the underlying distribution

Science.gov (United States)

Lo, Keng-Hsin; Wang, Kehluh; Hsu, Ming-Feng

2009-01-01

We develop a modified Edgeworth binomial model with higher moment consideration for pricing American Asian options. With lognormal underlying distribution for benchmark comparison, our algorithm is as precise as that of Chalasani et al. [P. Chalasani, S. Jha, F. Egriboyun, A. Varikooty, A refined binomial lattice for pricing American Asian options, Rev. Derivatives Res. 3 (1) (1999) 85-105] if the number of the time steps increases. If the underlying distribution displays negative skewness and leptokurtosis as often observed for stock index returns, our estimates can work better than those in Chalasani et al. [P. Chalasani, S. Jha, F. Egriboyun, A. Varikooty, A refined binomial lattice for pricing American Asian options, Rev. Derivatives Res. 3 (1) (1999) 85-105] and are very similar to the benchmarks in Hull and White [J. Hull, A. White, Efficient procedures for valuing European and American path-dependent options, J. Derivatives 1 (Fall) (1993) 21-31]. The numerical analysis shows that our modified Edgeworth binomial model can value American Asian options with greater accuracy and speed given higher moments in their underlying distribution.

A multivector derivative approach to Lagrangian field theory

International Nuclear Information System (INIS)

Lasenby, A.; Gull, S.; Doran, C.

1993-01-01

A new calculus, based upon the multivector derivative, is developed for Lagrangian mechanics and field theory, providing streamlined and rigorous derivations of the Euler-Lagrange equations. A more general form of Noether's theorem is found which is appropriate to both discrete and continuous symmetries. This is used to find the conjugate currents of the Dirac theory, where it improves on techniques previously used for analyses of local observables. General formulas for the canonical stress-energy and angular-momentum tensors are derived, with spinors and vectors treated in a unified way. It is demonstrated that the antisymmetric terms in the stress-energy tensor are crucial to the correct treatment of angular momentum. The multivector derivative is extended to provide a functional calculus for linear functions which is more compact and more powerful than previous formalisms. This is demonstrated in a reformulation of the functional derivative with respect to the metric, which is then used to recover the full canonical stress-energy tensor. Unlike conventional formalisms, which result in a symmetric stress-energy tensor, this reformulation retains the potentially important antisymmetric contribution. 23 refs

Frequency-domain waveform inversion using the phase derivative

KAUST Repository

Choi, Yun Seok

2013-09-26

Phase wrapping in the frequency domain or cycle skipping in the time domain is the major cause of the local minima problem in the waveform inversion when the starting model is far from the true model. Since the phase derivative does not suffer from the wrapping effect, its inversion has the potential of providing a robust and reliable inversion result. We propose a new waveform inversion algorithm using the phase derivative in the frequency domain along with the exponential damping term to attenuate reflections. We estimate the phase derivative, or what we refer to as the instantaneous traveltime, by taking the derivative of the Fourier-transformed wavefield with respect to the angular frequency, dividing it by the wavefield itself and taking the imaginary part. The objective function is constructed using the phase derivative and the gradient of the objective function is computed using the back-propagation algorithm. Numerical examples show that our inversion algorithm with a strong damping generates a tomographic result even for a high ‘single’ frequency, which can be a good initial model for full waveform inversion and migration.

Implementation problem for the canonical commutation relation in terms of quantum white noise derivatives

International Nuclear Information System (INIS)

Ji, Un Cig; Obata, Nobuaki

2010-01-01

The implementation problem for the canonical commutation relation is reduced to a system of differential equations for Fock space operators containing new type of derivatives. We solve these differential equations systematically by means of quantum white noise calculus, and obtain the solution to the implementation problem.

On the uniqueness of minimal coupling in higher-spin gauge theory

International Nuclear Information System (INIS)

Boulanger, Nicolas; Sundell, Per; Leclercq, Serge

2008-01-01

We address the uniqueness of the minimal couplings between higher-spin fields and gravity. These couplings are cubic vertices built from gauge non-invariant connections that induce non-abelian deformations of the gauge algebra. We show that Fradkin-Vasiliev's cubic 2-s-s vertex, which contains up to 2s-2 derivatives dressed by a cosmological constant Λ, has a limit where: (i) Λ → 0; (ii) the spin-2 Weyl tensor scales non-uniformly with s; and (iii) all lower-derivative couplings are scaled away. For s = 3 the limit yields the unique non-abelian spin 2-3-3 vertex found recently by two of the authors, thereby proving the uniqueness of the corresponding FV vertex. We extend the analysis to s = 4 and a class of spin 1-s-s vertices. The non-universality of the flat limit high-lightens not only the problematic aspects of higher-spin interactions with Λ = 0 but also the strongly coupled nature of the derivative expansion of the fully nonlinear higher-spin field equations with Λ≠0, wherein the standard minimal couplings mediated via the Lorentz connection are subleading at energy scales (|Λ|) 1/2 || E || M p . Finally, combining our results with those obtained by Metsaev, we give the complete list of all the manifestly covariant cubic couplings of the form 1-s-s and 2-s-s , in Minkowski background.

Interest Rate Risk Management and the Use of Derivative Securities

Directory of Open Access Journals (Sweden)

Ioana-Diana PĂUN

2013-12-01

Full Text Available This study aims to demonstrate the utility of derivative financial instruments for the management of interest rate risk that is faced by banks and financial institutions, and to provide an efficient flow of monitoring and control thereof. Banking institutions can now use a combination of balance sheet and off balance sheet measures, i.e. gap method, of interest rate risk management, in order to control exposure of short-term rates and derivatives to control the residual interest rate exposures. The result of the study shows that banks can achieve better diversification and risk management using derivatives.

Entanglement temperature with Gauss–Bonnet term

Directory of Open Access Journals (Sweden)

Shesansu Sekhar Pal

2015-09-01

Full Text Available We compute the entanglement temperature using the first law-like of thermodynamics, ΔE=TentΔSEE, up to Gauss–Bonnet term in the Jacobson–Myers entropy functional in any arbitrary spacetime dimension. The computation is done when the entangling region is the geometry of a slab. We also show that such a Gauss–Bonnet term, which becomes a total derivative, when the co-dimension two hypersurface is four dimensional, does not contribute to the finite term in the entanglement entropy. We observe that the Weyl-squared term does not contribute to the entanglement entropy. It is important to note that the calculations are performed when the entangling region is very small and the energy is calculated using the normal Hamiltonian.

Non-linear realizations and higher curvature supergravity

Energy Technology Data Exchange (ETDEWEB)

Farakos, F. [Dipartimento di Fisica e Astronomia ' ' Galileo Galilei' ' , Universita di Padova (Italy); INFN, Sezione di Padova (Italy); Ferrara, S. [Department of Theoretical Physics, Geneva (Switzerland); INFN - Laboratori Nazionali di Frascati, Frascati (Italy); Department of Physics and Astronomy, Mani L. Bhaumik Institute for Theoretical Physics, U.C.L.A., Los Angeles, CA (United States); Kehagias, A. [Physics Division, National Technical University of Athens (Greece); Luest, D. [Arnold Sommerfeld Center for Theoretical Physics, Muenchen (Germany); Max-Planck-Institut fuer Physik, Muenchen (Germany)

2017-12-15

We focus on non-linear realizations of local supersymmetry as obtained by using constrained superfields in supergravity. New constraints, beyond those of rigid supersymmetry, are obtained whenever curvature multiplets are affected as well as higher derivative interactions are introduced. In particular, a new constraint, which removes a very massive gravitino is introduced, and in the rigid limit it merely reduces to an explicit supersymmetry breaking. Higher curvature supergravities free of ghosts and instabilities are also obtained in this way. Finally, we consider direct coupling of the goldstino multiplet to the super Gauss-Bonnet multiplet and discuss the emergence of a new scalar degree of freedom. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Arbitrage-free valuation of energy derivatives

International Nuclear Information System (INIS)

Amin, K.; Ng, V.; Pirrong, C.

1999-01-01

This chapter focuses on techniques available for valuing energy-contingent claims and develops an arbitrage-free framework to value energy derivatives. The relationship between the spot, forward and futures prices is explained. Option valuation with deterministic convenience yields is discussed using an extension of the Black (1976) framework, and details of the risk-neutral valuation of European options, and valuation of American and European-style options are given. Option valuations with stochastic convenience yields, the evolution of the term structure of convenience yield, and a tree approach to valuing American and other options are discussed. Applications and limitations of the models for pricing energy derivative products are considered. The stochastic differential equation for the futures prices when the convenience yields are stochastic is presented in an appendix

Higher glandular trichome density in tomato leaflets and repellence to spider mites

International Nuclear Information System (INIS)

Maluf, Wilson Roberto; Inoue, Irene Fumi; Ferreira, Raphael de Paula Duarte; Gomes, Luiz Antonio Augusto; Castro, Evaristo Mauro de; Cardoso, Maria das Gracas

2007-01-01

The objective of this work was to evaluate the feasibility of selection for higher glandular trichome densities, as an indirect criterion of selection for increasing repellence to spider mites Tetranychus urticae, in tomato populations derived from an interspecific cross between Lycopersicon esculentum x L. hirsutum var. glabratum PI 134417. Trichome densities were evaluated in 19 genotypes, including 12 from advanced backcross populations, derived from the original cross L. esculentum x L. hirsutum var. glabratum PI 134417. Counts were made both on the adaxial and abaxial leaf surfaces, and trichomes were classified into glandular types IV and VI, other glandular types (types I+VII), and nonglandular types. Mite repellence was measured by distances walked by mites onto the tomato leaf surface after 20, 40 and 60 min. Spider mite repellence biotests indicated that higher densities of glandular trichomes (especially type VI) decreased the distances walked by the mites onto the tomato leaf surface. Selection of plants with higher densities of glandular trichomes can be an efficient criterion to obtain tomato genotypes with higher resistance (repellence) to spider mites. (author)

Mathematics, Pricing, Market Risk Management and Trading Strategies for Financial Derivatives (3/3)

CERN Multimedia

CERN. Geneva; Coffey, Brian

2009-01-01

IR and Long Term FX Derivatives - Stochastic Martingales for IR Curves - Implied Volatility Along the IR Curve - IR Libor Bonds - Vanilla IR Options: Caplets, Floorlets - Long Term FX Options: Interaction of Stochastic FX and Stochastic IR - $-Yen Bermudan Power Reverse Duals

78 FR 78519 - Appraisals for Higher-Priced Mortgage Loans

Science.gov (United States)

2013-12-26

... where the holder of the credit risk of the existing obligation remains the same on the refinancing. The....'' Specifically, new TILA section 129H prohibits a creditor from extending credit in the form of a ``higher-risk... rule.\\8\\ The term ``higher-risk mortgage'' generally encompasses a closed-end consumer credit...

Fredholm's minors of arbitrary order: their representations as a determinant of resolvents and in terms of free fermions and an explicit formula for their functional derivative

International Nuclear Information System (INIS)

Feinberg, Joshua

2004-01-01

We study the Fredholm minors associated with a Fredholm equation of the second type. We present a couple of new linear recursion relations involving the nth and (n - 1)th minors, whose solution is a representation of the nth minor as an n x n determinant of resolvents. The latter is given a simple interpretation in terms of a path integral over non-interacting fermions. We also provide an explicit formula for the functional derivative of a Fredholm minor of order n with respect to the kernel. Our formula is a linear combination of the nth and the (n ± 1)th minors

Successful Isolation of Viable Adipose-Derived Stem Cells from Human Adipose Tissue Subject to Long-Term Cryopreservation: Positive Implications for Adult Stem Cell-Based Therapeutics in Patients of Advanced Age

Directory of Open Access Journals (Sweden)

Sean M. Devitt

2015-01-01

Full Text Available We examined cell isolation, viability, and growth in adipose-derived stem cells harvested from whole adipose tissue subject to different cryopreservation lengths (2–1159 days from patients of varying ages (26–62 years. Subcutaneous abdominal adipose tissue was excised during abdominoplasties and was cryopreserved. The viability and number of adipose-derived stem cells isolated were measured after initial isolation and after 9, 18, and 28 days of growth. Data were analyzed with respect to cryopreservation duration and patient age. Significantly more viable cells were initially isolated from tissue cryopreserved 2 years, irrespective of patient age. However, this difference did not persist with continued growth and there were no significant differences in cell viability or growth at subsequent time points with respect to cryopreservation duration or patient age. Mesenchymal stem cell markers were maintained in all cohorts tested throughout the duration of the study. Consequently, longer cryopreservation negatively impacts initial live adipose-derived stem cell isolation; however, this effect is neutralized with continued cell growth. Patient age does not significantly impact stem cell isolation, viability, or growth. Cryopreservation of adipose tissue is an effective long-term banking method for isolation of adipose-derived stem cells in patients of varying ages.

Mothers with HIP - the short term and long-term impact, what is new?

Science.gov (United States)

Mecacci, Federico; Ottanelli, Serena; Petraglia, Felice

2018-05-03

Hyperglycemia is one of the most common medical conditions that women encounter during pregnancy and it is due to gestational diabetes (GDM) in the majority of cases [1]. GDM is associated with a higher incidence of maternal morbidity in pregnancy in term of hypertensive disorders/preclampsia and higher rate of cesarean delivery but also with long-term risk of type 2 diabetes and cardiovascular disease. Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk. Postpartum follow up provides an excellent opportunity to implement healthy lifestyle behaviors to prevent or delay the development of diabetes or cardiovascular disease. The aim of the current review is to focus on short and long term maternal morbidity of HIP. Copyright © 2018. Published by Elsevier B.V.

Comparison tests, in a pilot plant, of the performance of a coal-derived granular activated carbon: a comparison with coconut husk derived activated carbon

Energy Technology Data Exchange (ETDEWEB)

Hirata, S.; Kasahara, A.; Tsuruzono, Y.; Gotoh, M.

1986-01-01

A 160 m/sup 3//d pilot plant has been used in a series of comparison tests of the performance of coal-derived and coconut husk derived activated carbons. Activated carbons are used to remove trihalomethane precursors and malodorous substances from city water. A higher mean removal of coloration and COD/sub M//sub n/ was achieved with the coal-derived carbon (by factors of 1.5 and 1.8, respectively). The two activated carbons gave similar performances as regards turbidity, alkalinity, total iron and total manganese. 4 figures, 5 tables.

On the toroidal compactifications of bosonic strings in higher genus

International Nuclear Information System (INIS)

Semikhatov, A.M.

1989-01-01

For the bosonic string in a higher genus, compactified on the maximal torus of a simply laced Lie group, we discuss a possibility to construct an operator formalism involving only those operators that are well-defined globally over the whole Riemann surface. We find, in particular, higher genus extensions of (some combinations of) the vertex operators for the Kac-Moody algebra. This allows us to derive the relation between the Sugawara and Virasoro constructions of the energy-momentum tensor on Riemann surfaces, and to propose an operator mechanism underlying the construction of group current correlation functions in higher genus. (orig.)

Higher spin black holes with soft hair

Energy Technology Data Exchange (ETDEWEB)

Grumiller, Daniel [Institute for Theoretical Physics, TU Wien,Wiedner Hauptstrasse 8-10/136, Vienna, A-1040 (Austria); Pérez, Alfredo [Centro de Estudios Científicos (CECs),Av. Arturo Prat 514, Valdivia (Chile); Prohazka, Stefan [Institute for Theoretical Physics, TU Wien,Wiedner Hauptstrasse 8-10/136, Vienna, A-1040 (Austria); Tempo, David; Troncoso, Ricardo [Centro de Estudios Científicos (CECs),Av. Arturo Prat 514, Valdivia (Chile)

2016-10-21

We construct a new set of boundary conditions for higher spin gravity, inspired by a recent “soft Heisenberg hair”-proposal for General Relativity on three-dimensional Anti-de Sitter space. The asymptotic symmetry algebra consists of a set of affine û(1) current algebras. Its associated canonical charges generate higher spin soft hair. We focus first on the spin-3 case and then extend some of our main results to spin-N, many of which resemble the spin-2 results: the generators of the asymptotic W{sub 3} algebra naturally emerge from composite operators of the û(1) charges through a twisted Sugawara construction; our boundary conditions ensure regularity of the Euclidean solutions space independently of the values of the charges; solutions, which we call “higher spin black flowers”, are stationary but not necessarily spherically symmetric. Finally, we derive the entropy of higher spin black flowers, and find that for the branch that is continuously connected to the BTZ black hole, it depends only on the affine purely gravitational zero modes. Using our map to W-algebra currents we recover well-known expressions for higher spin entropy. We also address higher spin black flowers in the metric formalism and achieve full consistency with previous results.

Another higher order Langevin algorithm for QCD

International Nuclear Information System (INIS)

Kronfeld, A.S.

1986-01-01

This note provides an algorithm for integrating the Langevin equation which is second order. It introduces a term into the drift force which is a product of the Gaussian noise and a second derivative of the action. The specific application presented here is for nonabelian gauge theories interacting with fermions, e.g. QCD, for which it requires less memory than the Runge-Kutta algorithm of the same order. The memory and computational requirements of Euler, Runge-Kutta, and the present algorithm are compared. (orig.)

Invariant functionals in higher-spin theory

Directory of Open Access Journals (Sweden)

M.A. Vasiliev

2017-03-01

Full Text Available A new construction for gauge invariant functionals in the nonlinear higher-spin theory is proposed. Being supported by differential forms closed by virtue of the higher-spin equations, invariant functionals are associated with central elements of the higher-spin algebra. In the on-shell AdS4 higher-spin theory we identify a four-form conjectured to represent the generating functional for 3d boundary correlators and a two-form argued to support charges for black hole solutions. Two actions for 3d boundary conformal higher-spin theory are associated with the two parity-invariant higher-spin models in AdS4. The peculiarity of the spinorial formulation of the on-shell AdS3 higher-spin theory, where the invariant functional is supported by a two-form, is conjectured to be related to the holomorphic factorization at the boundary. The nonlinear part of the star-product function F⁎(B(x in the higher-spin equations is argued to lead to divergencies in the boundary limit representing singularities at coinciding boundary space–time points of the factors of B(x, which can be regularized by the point splitting. An interpretation of the RG flow in terms of proposed construction is briefly discussed.

Assessment of stress tolerance acquisition in the heat-tolerant derivative strains of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG.

Science.gov (United States)

Aakko, J; Sánchez, B; Gueimonde, M; Salminen, S

2014-07-01

The purpose of this study was to investigate the heat-shock response at molecular level in Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12 and their heat-tolerant derivatives and to characterize the changes that make the derivatives more robust in terms of heat stress. The study strains were exposed for 2 h to a heat-shock treatment, Bif. animalis subsp. lactis BB-12 and its derivative at 50°C and the Lact. rhamnosus GG and its derivative at 60°C. Protein synthesis before and after heat shock was examined using proteomics and RT-qPCR. The analysis revealed that the regulation of seven proteins in both strain pairs was modified as a response to heat or between the original and the derivative strain. The comparison of wild-type strains and the heat-tolerant derivatives suggests that the acquisition of heat tolerance in the Bif. animalis subsp. lactis BB-12 derivative is due to a slightly increased constitutive level of chaperones, while in Lact. rhamnosus GG derivative, the main reason seems to be a higher ability to induce the production of chaperones. This study revealed possible markers of heat tolerance in B. lactis and Lact. rhamnosus strains. This study increases our knowledge on how Lactobacillus and Bifidobacterium strains may acquire heat tolerance. These findings may be useful for improving the heat tolerance of existing probiotic strains as well as screening new heat-tolerant strains. © 2014 The Society for Applied Microbiology.

Silsesquioxane-derived ceramic fibres