WorldWideScience

Sample records for higher ars scores

  1. Chemotherapy-Induced Fatigue Correlates With Higher Fatigue Scores Before Treatment.

    Science.gov (United States)

    Araújo, José Klerton Luz; Giglio, Adriana Del; Munhoz, Bruna Antenusse; Fonseca, Fernando Luiz Affonso; Cruz, Felipe Melo; Giglio, Auro Del

    2017-06-01

    Cancer chemotherapy can induce fatigue in about 20% to 30% of patients. So far, there is very little information as to the predictors of chemotherapy-induced fatigue (CIF). We evaluated potential predictors of CIF in a sample of patients with cancer with several types of solid tumors scheduled to receive chemotherapy according to institutional protocols. Before their first and second chemotherapy cycles, patients answered to the Brief Fatigue Inventory (BFI), Chalder, Mini Nutritional Assessment (MNA), Stress thermometer, and HADS questionnaires as well as provided blood samples for inflammatory markers. We evaluated 52 patients, 37 (71%) were female and mean age was 53 years. The most common tumors were breast cancer 21 (40%) and gastrointestinal tumors 12 (23%). Although 14 (25.2%) patients had an increase in their fatigue BFI scores equal or above 3 points from baseline, we observed no significant overall differences between BFI scores before and after chemotherapy. The only 2 factors associated with an increase of 3 points in the BFI scores after chemotherapy were race and higher baseline BFI levels. By multivariate analysis, overall BFI and Chalder scores after chemotherapy also correlated significantly with their respective baseline scores before treatment. HADS scores before treatment correlated with overall BFI scores postchemotherapy, whereas MNA scores before chemotherapy and female sex correlated with higher Chalder scores after treatment. We conclude that fatigue induced by chemotherapy is common and consistently associated with higher fatigue scores before treatment. Screening for fatigue before chemotherapy may help to identify patients who are prone to develop CIF.

  2. K/Ar hornblende ages from the higher Himalaya: implications for India-Asia collision and Himalayan metamorphosis

    International Nuclear Information System (INIS)

    Sorkhabi, R.B.; Stump, A.K.; Jain, A.K.; Manickavasagam, R.M.; Nishimura Susumu

    1993-01-01

    Two amphibolite samples from the Higher Himalayan Crystalline (HHC) belt from the Suru Valley, Zanskar, have yielded Eocene K/Ar hornblende cooling ages between 40 and 45 Ma, thus indicating much older peak metamorphic conditions in northern parts of the Indian Plate. These ages are in conformity with almost identical ages from metamorphic complexes across the Nanga Parbat syntaxis in Pakistan and reveal a 65 to 70-Ma collision phase of the Indian indentor in the NW-Himalaya. (author). 21 refs., 2 figs

  3. Connection between weighted LPC and higher-order statistics for AR model estimation

    NARCIS (Netherlands)

    Kamp, Y.; Ma, C.

    1993-01-01

    This paper establishes the relationship between a weighted linear prediction method used for robust analysis of voiced speech and the autoregressive modelling based on higher-order statistics, known as cumulants

  4. Longitudinal AddiQoL scores may identify higher risk for adrenal crises in Addison's disease.

    Science.gov (United States)

    Meyer, Gesine; Koch, Maike; Herrmann, Eva; Bojunga, Jörg; Badenhoop, Klaus

    2018-05-01

    Several studies have shown a reduced quality of life (QoL) in patients with Addison's disease (AD), but investigations of QoL over a long-term course are lacking. Adrenal crises (AC) are life-threatening complications in AD. The purpose of this prospective study was to test whether the repeated use of QoL-questionnaires can detect prodromal periods of an AC. 110 patients with AD were asked to complete the disease specific-QoL questionnaire AddiQoL and a short questionnaire about adverse events once monthly over a period of ten months. AC was defined if at least two of the following symptoms were reported: (a) hypotension, (b) nausea or vomiting, (c) severe fatigue, (d) documented hyponatremia, hyperkalemia, or hypoglycemia, and subsequent parenteral glucocorticoid administration was carried out. Prevalence of AC was 10.9/100 patient years. AddiQoL scores in patients with AC showed a trend (p = 0,08) to a wider fluctuation over time. Subjective precrises not meeting the criteria for AC were reported by 31 patients who had significantly lower AddiQoL scores (p = 0,018). These are the first data showing the course of QoL during a period of ten months in patients with AD. Incidence of AC exceeds previous data. Our data show, that subjective precrises in AD associate with lower QoL. AC, as well as precrises affect intraindividual AddiQol-scores over time with a trend to a stronger fluctuation. Longitudinal AddiQol scores and self-reporting of precrises via patient diaries are additional clinical tools to identify higher risk for critical events.

  5. Higher dietary diversity score is associated with obesity: a case-control study.

    Science.gov (United States)

    Karimbeiki, R; Pourmasoumi, M; Feizi, A; Abbasi, B; Hadi, A; Rafie, N; Safavi, S M

    2018-04-01

    The present study was carried out to compare dietary diversity score (DDS) among overweight, obese, and normal-weight adults. This case-control study was conducted with a total of 200 cases (100 participants with obesity and 100 participants with overweight) and 300 controls (normal weight) matched by socio-economic status (SES), older than 18 years. Dietary intakes were assessed using a self-administered Food Frequency Questionnaire. Data regarding physical activity and sociodemographic variables were gathered. DDS was computed based on the scoring of the five food groups emphasized in the United States Department of Agriculture Food Guide Pyramid. Anthropometric measurements were measured, and the body mass index and waist-to-hip ratio were calculated. The mean ± standard deviation of DDS was higher in participants with obesity (5.65 ± 1.32) than that in overweight participants (5.23 ± 1.23), while the lowest score was reported among normal-weight individuals (4.97 ± 1.42) (P obesity increased with each unit increase in DDS (odds ratio [OR]: 1.46; 95% confidence interval [CI]: 1.22, 1.74). However, the association became slightly weaker after adjusting for potential confounding factors (OR: 1.34; 95% CI: 1.07, 1.68). It was concluded that there was a significant positive association between DDS and obesity. However, additional investigations are warranted. Copyright © 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  6. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens

    Directory of Open Access Journals (Sweden)

    Leonardo Oliveira Reis

    2013-01-01

    Full Text Available Background. Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition. Patients and Methods. Consecutive 343 patients were categorized at biopsy (BGS and prostatectomy (PGS as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4% had PSA recurrence, mean followup 80.2 months (median 99. Independent predictors of Gleason upgrading (logistic regression and disease-free survival (DFS (Kaplan-Meier, log-rank were determined. Results. Gleason discordance was 45.7% (37.32% upgrading and 8.45% downgrading. Upgrading risk decreased by 2.4% for each 1 g of prostate weight increment, while it increased by 10.2% for every 1 ng/mL of PSA, 72.0% for every 0.1 unity of PSA density and was 21 times higher for those with BGS 7. Gleason upgrading showed increased clinical stage (P=0.019, higher tumor extent (P=0.009, extraprostatic extension (P=0.04, positive surgical margins (P<0.001, seminal vesicle invasion (P=0.003, less “insignificant” tumors (P<0.001, and also worse DFS, χ2=4.28, df=1, P=0.039. However, when setting the final Gleason score (BGS ≤6 to PGS 7 versus BGS 7 to PGS 7, avoiding allocation bias, DFS impact is not confirmed, χ2=0.40, df=1, P=0.530.Conclusions. Gleason upgrading is substantial and confers worse outcomes. Prostate weight is inversely related to upgrading and its protective effect warrants further evaluation.

  7. Infections after shoulder arthroplasty are correlated with higher anesthetic risk score: a case-control study in Brazil

    Directory of Open Access Journals (Sweden)

    Leonardo Hideto Nagaya

    2017-11-01

    Conclusion: This study provides evidence suggesting that patient-related known factors such as higher ASA score predisposes to shoulder arthroplasty-associated infection. Furthermore, unusual pathogens associated with PSI were identified.

  8. Ars disyecta Ars disyecta

    Directory of Open Access Journals (Sweden)

    Alejandra Castillo

    2012-07-01

    Full Text Available Bajo la nominación Ars Disyecta se busca exponer el vínculo entre artes visuales, feminismo y metamorfosis. Las prácticas artísticas feministas aquí presentadas se proponen perturbar el espacio metafórico heredado de la diferencia sexual (pensemos, por ejemplo, en las palabras engendramiento, matriz, vida, compenetración o invaginamiento. En este sentido, la nominación Ars disyecta pone en escena un conjunto de prácticas e intervenciones que intentan interrumpir la matriz de la diferencia, desestabilizando lo femenino desde aquellas figuras que se resisten a la lógica de la totalidad y de un tiempo propio. Buscando seguir la huella de un arte disyecto es que interrogaré en este ensayo aquellas autorías feministas que en el arte contemporáneo trafican con las huellas del contagio, la mutación y la alteridad.This article aims to present the relation between visual arts, feminism I and metamorphosis. The feminist artistic practices portrayed in this article attempt to question categories inherited from the metaphor of sexual difference such as engendering, matrix and life. From this perspective, Ars disyecta will establish a set of artistic practices and interventions that intend to interrupt the proper idea of «feminine difference». Following this line of argument, I will discuss in this article a few contemporary feminist works of art that could be defined by words such as contagious, mutation and otherness.

  9. Higher Mobility Scores in Patients with Cystic Fibrosis Are Associated with Better Lung Function

    Directory of Open Access Journals (Sweden)

    Aneesha Thobani

    2015-01-01

    Full Text Available Objective. The purpose of this study was to determine whether mobility and physical activity were associated with lung function in adults with cystic fibrosis (CF. Design. This was a prospective cohort observational study in an urban, academic, specialized care center. Participants were ambulatory, nonhospitalized adults with CF. Main Outcome Measures. Mobility was assessed monthly by the Life-Space Assessment (LSA questionnaire and quarterly by pedometer. Lung function was assessed by spirometry. Results. Twenty-seven subjects participated. Subjects recorded mean pedometer steps of 20,213 ± 11,331 over three days and FEV1% predicted of 77.48% ± 22.60% over one year. The LSA score at enrollment was correlated with initial pedometer steps (r=0.42 and P=0.03, and mean LSA score over one year was correlated with mean number of steps (r=0.51 and P=0.007. LSA mobility and pedometer scores were correlated with FEV1% predicted at enrollment and throughout the study. Conclusions. Mobility and physical activity measured by LSA questionnaire and pedometer are positively associated with lung function in adults with CF. This study confirms the importance of mobility and physical activity and supports the utility of a simple office-based questionnaire as a measure of mobility in adults with CF.

  10. Higher mobility scores in patients with cystic fibrosis are associated with better lung function.

    Science.gov (United States)

    Thobani, Aneesha; Alvarez, Jessica A; Blair, Shaina; Jackson, Kaila; Gottlieb, Eric R; Walker, Seth; Tangpricha, Vin

    2015-01-01

    The purpose of this study was to determine whether mobility and physical activity were associated with lung function in adults with cystic fibrosis (CF). This was a prospective cohort observational study in an urban, academic, specialized care center. Participants were ambulatory, nonhospitalized adults with CF. Mobility was assessed monthly by the Life-Space Assessment (LSA) questionnaire and quarterly by pedometer. Lung function was assessed by spirometry. Twenty-seven subjects participated. Subjects recorded mean pedometer steps of 20,213 ± 11,331 over three days and FEV1% predicted of 77.48% ± 22.60% over one year. The LSA score at enrollment was correlated with initial pedometer steps (r = 0.42 and P = 0.03), and mean LSA score over one year was correlated with mean number of steps (r = 0.51 and P = 0.007). LSA mobility and pedometer scores were correlated with FEV1% predicted at enrollment and throughout the study. Mobility and physical activity measured by LSA questionnaire and pedometer are positively associated with lung function in adults with CF. This study confirms the importance of mobility and physical activity and supports the utility of a simple office-based questionnaire as a measure of mobility in adults with CF.

  11. Higher stress scores for female medical students measured by the Kessler Psychological Distress Scale (K10 in Pakistan

    Directory of Open Access Journals (Sweden)

    Khadija Qamar

    2014-10-01

    Full Text Available The aim of this study was to determine the stress level of medical students and the relationship between stress and academic year. A cross-sectional, descriptive study was conducted at an undergraduate medical school with a five-year curriculum, in Pakistan, from January 2014 to April 2014. Medical students in the first four years were included in the study. The Kessler Psychological Distress Scale (K10, a self-administered questionnaire, was distributed to the students. A total of 445 medical students completed the questionnaire. The average stress score was 19.61 (SD = 6.76 with a range from 10 to 43. Stress was experienced by 169 students (41.7%. The scores of female students were higher than scores of males, indicating a higher stress level (P = 0.011. The relationship between stress and academic year was insignificant (P = 0.392.

  12. Impact of Answer-Switching Behavior on Multiple-Choice Test Scores in Higher Education

    Directory of Open Access Journals (Sweden)

    Ramazan BAŞTÜRK

    2011-06-01

    Full Text Available The multiple- choice format is one of the most popular selected-response item formats used in educational testing. Researchers have shown that Multiple-choice type test is a useful vehicle for student assessment in core university subjects that usually have large student numbers. Even though the educators, test experts and different test recourses maintain the idea that the first answer should be retained, many researchers argued that this argument is not dependent with empirical findings. The main question of this study is to examine how the answer switching behavior affects the multiple-choice test score. Additionally, gender differences and relationship between number of answer switching behavior and item parameters (item difficulty and item discrimination were investigated. The participants in this study consisted of 207 upper-level College of Education students from mid-sized universities. A Midterm exam consisted of 20 multiple-choice questions was used. According to the result of this study, answer switching behavior statistically increase test scores. On the other hand, there is no significant gender difference in answer-switching behavior. Additionally, there is a significant negative relationship between answer switching behavior and item difficulties.

  13. Predictive Power of Primary and Secondary School Success Criterion on Transition to Higher Education Examination Scores

    OpenAIRE

    Atilla ÖZDEMİR; Selahattin GELBAL

    2016-01-01

    It is seen that education has a significant effect that changes an individual’s life in our country in which education is a way of moving up the social ladder. In order to continue to a higher education program after graduating from high school, students have to succeed in transition to higher education examination. Thus, the entrance exam is an important factor to determine the future of the students. In our country, middle school grades and high school grade point average that is added to u...

  14. Greater Equality: The Hidden Key to Better Health and Higher Scores

    Science.gov (United States)

    Wilkinson, Richard; Pickett, Kate

    2011-01-01

    There are now many studies of income inequality and health that compare countries, American states, or other large regions, and the majority of these studies show that more egalitarian societies tend to be healthier. Inequality is associated with lower life expectancy, higher rates of infant mortality, shorter height, poor self-reported health,…

  15. Effects of honours programme participation in higher education : A propensity score matching approach

    NARCIS (Netherlands)

    Kool, Ada; Mainhard, Tim; Jaarsma, Debbie; van Beukelen, Peter; Brekelmans, Mieke

    2017-01-01

    Honours programmes have become part of higher education systems around the globe, and an increasing number of students are enrolled in such programmes. So far, effects of these programmes are largely under-researched. Two gaps in previous research on the effects of such programmes were addressed:

  16. Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening.

    Science.gov (United States)

    Padilla, Claudia; Mendez, Mario F; Jimenez, Elvira E; Teng, Edmond

    2016-11-24

    Bilingualism may protect against cognitive aging and delay the onset of dementia. However, studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confounding variables and methodological concerns. We addressed this issue by comparing cognitive performance in a more culturally homogeneous cohort of older Spanish-speaking monolingual (n = 289) and Spanish-English bilingual (n = 339) Mexican-American immigrants from the Sacramento Longitudinal Study on Aging. After adjusting for demographic differences and depressive symptoms, both groups performed similarly at baseline on verbal memory but the bilingual group performed significantly better than the monolingual group on a cognitive screening test, the Modified Mini-Mental State Examination (3MS; p bilingual group, neither language of testing nor degree of bilingualism was significantly associated with 3MS or verbal memory scores. Amongst individuals who performed in the normal or better range on both tests at baseline and were followed for an average of 6 years, both monolinguals and bilinguals exhibited similar rates of cognitive decline on both measures. These findings suggest that bilingualism is associated with modest benefits in cognitive screening performance in older individuals in cross-sectional analyses that persist across longitudinal analyses. The effects of bilingualism should be considered when cognitively screening is performed in aging immigrant populations.

  17. Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening

    Directory of Open Access Journals (Sweden)

    Claudia Padilla

    2016-11-01

    Full Text Available Abstract Background Bilingualism may protect against cognitive aging and delay the onset of dementia. However, studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confounding variables and methodological concerns. Methods We addressed this issue by comparing cognitive performance in a more culturally homogeneous cohort of older Spanish-speaking monolingual (n = 289 and Spanish-English bilingual (n = 339 Mexican-American immigrants from the Sacramento Longitudinal Study on Aging. Results After adjusting for demographic differences and depressive symptoms, both groups performed similarly at baseline on verbal memory but the bilingual group performed significantly better than the monolingual group on a cognitive screening test, the Modified Mini-Mental State Examination (3MS; p < 0.001. Group differences on the 3MS were driven by language/executive and language/praxis factors. Within the bilingual group, neither language of testing nor degree of bilingualism was significantly associated with 3MS or verbal memory scores. Amongst individuals who performed in the normal or better range on both tests at baseline and were followed for an average of 6 years, both monolinguals and bilinguals exhibited similar rates of cognitive decline on both measures. Conclusions These findings suggest that bilingualism is associated with modest benefits in cognitive screening performance in older individuals in cross-sectional analyses that persist across longitudinal analyses. The effects of bilingualism should be considered when cognitively screening is performed in aging immigrant populations.

  18. NAPLAN Scores as Predictors of Access to Higher Education in Victoria

    OpenAIRE

    Brendan Houng; Moshe Justman

    2014-01-01

    This paper examines the extent to which year-9 performance on the National Assessment Program—Language Arts and Numeracy (NAPLAN) predicts access to higher education as determined by subsequent achievement on year-12 Victoria Certificate of Education (VCE) exams. VCE performance is measured via three binary indicators: achieving an Australian tertiary admission rank (ATAR) above 50 ("ATAR50"), above 70 ("ATAR70"), and above 90 ("ATAR90"); and two continuous indicators: ATAR and the Tertiary E...

  19. A higher score on the Aging Males' Symptoms scale is associated with insulin resistance in middle-aged men.

    Science.gov (United States)

    Hamanoue, Nobuya; Tanabe, Makito; Tanaka, Tomoko; Akehi, Yuko; Murakami, Junji; Nomiyama, Takashi; Yanase, Toshihiko

    2017-05-30

    An age-associated androgen decrease and its pathological conditions are defined as late-onset hypogonadism (LOH). Among the various symptoms associated with LOH, a visceral fat increase is strongly associated with relatively low levels of testosterone. However, few studies have investigated the relationship between the Aging Males' Symptoms (AMS) scores and metabolic abnormalities. Thus, we aimed to clarify this relationship by investigating the relationship between AMS scores and various markers in blood. During routine health examinations in 241 middle-aged males (52.7±7.5 years of age, mean±SD), 150 males (62.2%) displayed higher AMS values than normal. No statistical association was observed between total AMS scores and any testosterone value. All mental, physical and sexual AMS subscales were significantly positively correlated with insulin levels and HOMA-IR. Only sexual subscale scores were significantly inversely associated with free or bioavailable testosterone level. Males with insulin resistance (HOMA-IR≥2.5) demonstrated significantly higher AMS scores than those with normal insulin sensitivity (HOMA-IRinsulin and HOMA-IR values. Interestingly, univariate and multivariate analyses revealed that HOMA-IR≥2.5 was a significant predictor for detection of moderately severe AMS values (AMS≥37), whereas AMS≥37 was not a predictor of metabolic syndrome by International Diabetes Federation (IDF) criterion. In conclusion, almost 60% of healthy male subjects displayed abnormal AMS scores. AMS values were not associated with testosterone values but rather were related to insulin resistance, particularly in subjects with moderately severe AMS values. Insulin resistance-related general unwellness might be reflected by AMS values.

  20. Preparation and characterization of pulsed laser deposited CdTe thin films at higher FTO substrate temperature and in Ar + O{sub 2} atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Chao; Ming, Zhenxun [College of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan (China); Li, Bing, E-mail: libing70@126.com [College of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan (China); Feng, Lianghuan [College of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan (China); Wu, Judy [Department of Physics and Astronomy, Kansas University, Lawrence 66045 (United States)

    2013-06-20

    Highlights: • CdTe films were deposited by PLD at high substrate temperatures (400 °C, 550 °C). • CdTe films were achieved under the atmosphere (1.2 Torr) of Ar mixed with O{sub 2}. • Deposited CdTe films were cubic phase and had strong (1 0 0) preferred orientation. • Scanning electron microscope (SEM) showed an average grain size of 0.3–0.6 μm. • The ultra-thin film (CdS/PLD-CdTe) solar cell with efficiency of 6.68% was made. -- Abstract: Pulsed laser deposition (PLD) is one of the promising techniques for depositing cadmium telluride (CdTe) thin films. It has been reported that PLD CdTe thin films were almost deposited at the lower substrate temperatures (<300 °C) under vacuum conditions. However, the poor crystallinity of CdTe films prepared in this way renders them not conducive to the preparation of high-efficiency CdTe solar cells. To obtain high-efficiency solar cell devices, better crystallinity and more suitable grain size are needed, which requires the CdTe layer to be deposited by PLD at high substrate temperatures (>400 °C). In this paper, CdTe layers were deposited by PLD (KrF, λ = 248 nm, 10 Hz) at different higher substrate temperatures (T{sub s}). Excellent performance of CdTe films was achieved at higher substrate temperatures (400 °C, 550 °C) under an atmosphere of Ar mixed with O{sub 2} (1.2 Torr). X-ray diffraction analysis confirmed the formation of CdTe cubic phase with a strong (1 0 0) preferential orientation at all substrates temperatures on 60 mJ laser energy. The optical properties of CdTe were investigated, and the band gaps of CdTe films were 1.51 eV and 1.49 eV at substrate temperatures of 400 °C and 550 °C, respectively. Scanning electron microscopy (SEM) showed an average grain size of 0.3–0.6 μm. Thus, under these conditions of the atmosphere of Ar + O{sub 2} (15 Torr) and at the relatively high T{sub s} (500 °C), an thin-film (FTO/PLD-CdS (100 nm)/PLD-CdTe (∼1.5 μm)/HgTe: Cu/Ag) solar cell with an

  1. Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust

    DEFF Research Database (Denmark)

    Giesinger, Johannes M.; Kieffer, Jacobien M.; Fayers, Peter M.

    2016-01-01

    OBJECTIVE: To further evaluate the higher order measurement structure of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), with the aim of generating a summary score. STUDY DESIGN AND SETTING: Using pretreatment QLQ-C30 data (N...... = 3,282), we conducted confirmatory factor analyses to test seven previously evaluated higher order models. We compared the summary score(s) derived from the best performing higher order model with the original QLQ-C30 scale scores, using tumor stage, performance status, and change over time (N = 244......) as grouping variables. RESULTS: Although all models showed acceptable fit, we continued in the interest of parsimony with known-groups validity and responsiveness analyses using a summary score derived from the single higher order factor model. The validity and responsiveness of this QLQ-C30 summary score...

  2. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.

    Science.gov (United States)

    Gatchel, Jennifer R; Donovan, Nancy J; Locascio, Joseph J; Becker, J Alex; Rentz, Dorene M; Sperling, Reisa A; Johnson, Keith A; Marshall, Gad A

    2017-07-01

    Apathy is among the earliest and most pervasive neuropsychiatric symptoms in prodromal and mild Alzheimer disease (AD) dementia that correlates with functional impairment and disease progression. We investigated the association of apathy with regional 18F-fluorodeoxyglucose (FDG) metabolism in cognitively normal, mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative database. Cross-sectional and longitudinal studies. 57 North American research sites. 402 community dwelling elders. Apathy was assessed using the Neuropsychiatric Inventory Questionnaire. Baseline FDG metabolism in five regions implicated in the neurobiology of apathy and AD was investigated in relationship to apathy at baseline (cross-sectional general linear model) and longitudinally (mixed random/fixed effect model). Covariates included age, sex, diagnosis, apolipoprotein E genotype, premorbid intelligence, cognition, and antidepressant use. Cross-sectional analysis revealed that posterior cingulate hypometabolism, diagnosis, male sex, and antidepressant use were associated with higher apathy scores. Longitudinal analysis revealed that the interaction of supramarginal hypometabolism and time, posterior cingulate hypometabolism, and antidepressant use were associated with higher apathy scores across time; only supramarginal hypometabolism was positively related to rate of increase of apathy. Results support an association of apathy with hypometabolism in parietal regions commonly affected in early stages of AD, rather than medial frontal regions implicated in the neurobiology of apathy in later stages. Further work is needed to substantiate whether this localization is specific to apathy rather than to disease stage, and to investigate the potential role of AD proteinopathies in the pathogenesis of apathy. Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  3. Ars Electronica

    DEFF Research Database (Denmark)

    Kristensen, Thomas Bjørnsten

    2009-01-01

    Anmeldelse af Ars Electronica festivalen 3. - 8. september, 2009 i Linz, Østrig, der fejrede 30 års jubilæum under temaet "Human Nature". Festivalen fokuserer på interaktion mellem menneske, teknologi, kunst og samfund med særlig vægt på udviklingen af computeren og det digitale. Udgivelsesdato: 15.12...

  4. Influence of residual Ar+ in Ar cluster ion beam for DLC film formation

    International Nuclear Information System (INIS)

    Kitagawa, Teruyuki; Miyauchi, Kazuya; Toyoda, Noriaki; Kanda, Kazuhiro; Ikeda, Tokumi; Tsubakino, Harushige; Matsuo, Jiro; Matsui, Shinji; Yamada, Isao

    2003-01-01

    In order to study the influences of residual Ar monomer ion (Ar + ) on sp 2 content and hardness of diamond like carbon (DLC) films formed by Ar cluster ion beam assisted deposition, Ar cluster ion, Ar + and their mixed ions (Ar cluster ion and Ar + ) bombardments were performed during evaporation of C 60 . From near edge X-ray absorption fine structure (NEXAFS) and Raman spectroscopy measurements, lower sp 2 content in the carbon films was obtained with Ar cluster ion bombardment than that with Ar + and mixed ion. Furthermore higher hardness and smooth surface were shown with Ar cluster ion bombardments. Therefore it was important to reduce Ar + in Ar cluster ion beams to obtain hard DLC films with flat surface

  5. Raising test scores vs. teaching higher order thinking (HOT): senior science teachers' views on how several concurrent policies affect classroom practices

    Science.gov (United States)

    Zohar, Anat; Alboher Agmon, Vered

    2018-04-01

    This study investigates how senior science teachers viewed the effects of a Raising Test Scores policy and its implementation on instruction of higher order thinking (HOT), and on teaching thinking to students with low academic achievements.

  6. Higher IELTS Score, Higher Academic Performance?\\ud The Validity of IELTS in Predicting the Academic Performance\\ud of Chinese Students

    OpenAIRE

    Yen, Dorothy; Kuzma, Joanne

    2009-01-01

    The International English Language Testing System (IELTS) is widely accepted as a reliable means of assessing whether candidates are ready to study or train in the medium of the English language. It consists of four key parts: reading, speaking, listening and writing. Before enrolling onto any HE programmes at the University of Worcester, international students are required to take the IELTS exam and obtain a\\ud score of 6.0 and above, indicating a satisfactory command of English. However, de...

  7. Right-handers have negligibly higher IQ scores than left-handers: Systematic review and meta-analyses.

    Science.gov (United States)

    Ntolka, Eleni; Papadatou-Pastou, Marietta

    2018-01-01

    The relationship between intelligence and handedness remains a matter of debate. The present study is a systematic review of 36 studies (totaling 66,108 individuals), which have measured full IQ scores in different handedness groups. Eighteen of those studies were further included in three sets of meta-analyses (totaling 20,442 individuals), which investigated differences in standardized mean IQ scores in (i) left-handers, (ii) non-right-handers, and (iii) mixed-handers compared to right-handers. The bulk of the studies included in the systematic review reported no differences in IQ scores between left- and right-handers. In the meta-analyses, statistically significant differences in mean IQ scores were detected between right-handers and left-handers, but were marginal in magnitude (d=-0.07); the data sets were found to be homogeneous. Significance was lost when the largest study was excluded. No differences in mean IQ scores were found between right-handers and non-right-handers as well as between right-handers and mixed-handers. No sex differences were found. Overall, the intelligence differences between handedness groups in the general population are negligible. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Peer-instructed seminar attendance is associated with improved preparation, deeper learning and higher exam scores : A survey study

    NARCIS (Netherlands)

    Bouwmeester, Rianne A M; De Kleijn, Renske A M; Van Rijen, Harold V M

    2016-01-01

    Background: Active engagement in education improves learning outcomes. To enhance active participation in seminars, a student-centered course design was implemented and evaluated in terms of self-reported preparation, student motivation and exam scores. We hypothesized that small group learning with

  9. “Always Look on the Bright Side of Life!” – Higher Hypomania Scores Are Associated with Higher Mental Toughness, Increased Physical Activity, and Lower Symptoms of Depression and Lower Sleep Complaints

    Directory of Open Access Journals (Sweden)

    Leila Jahangard

    2017-12-01

    Full Text Available Background: In the present study, we explored the associations between hypomania, symptoms of depression, sleep complaints, physical activity and mental toughness. The latter construct has gained interest for its association with a broad variety of favorable behavior in both clinical and non-clinical samples.Subjects and Methods: The non-clinical sample consisted of 206 young adults (M = 21.3 years; age range: 18–24 years; 57.3% males. They completed questionnaires covering hypomania, mental toughness, symptoms of depression, physical activity, and sleep quality.Results: Higher hypomania scores were associated with higher mental toughness, increased physical activity, lower symptoms of depression and lower sleep complaints. No gender differences were observed. Higher hypomania scores were predicted by higher scores of mental toughness subscales of control and challenge, and physical activity.Conclusion: The pattern of results suggests that among a non-clinical sample of young adults, self-rated hypomania scores were associated with higher scores on mental toughness and physical activity, along with lower depression and sleep complaints. The pattern of results further suggests that hypomania traits are associated with a broad range of favorable psychological, behavioral and sleep-related traits, at least among a non-clinical sample of young adults.

  10. "Always Look on the Bright Side of Life!" - Higher Hypomania Scores Are Associated with Higher Mental Toughness, Increased Physical Activity, and Lower Symptoms of Depression and Lower Sleep Complaints.

    Science.gov (United States)

    Jahangard, Leila; Rahmani, Anahita; Haghighi, Mohammad; Ahmadpanah, Mohammad; Sadeghi Bahmani, Dena; Soltanian, Ali R; Shirzadi, Shahriar; Bajoghli, Hafez; Gerber, Markus; Holsboer-Trachsler, Edith; Brand, Serge

    2017-01-01

    Background: In the present study, we explored the associations between hypomania, symptoms of depression, sleep complaints, physical activity and mental toughness. The latter construct has gained interest for its association with a broad variety of favorable behavior in both clinical and non-clinical samples. Subjects and Methods: The non-clinical sample consisted of 206 young adults ( M = 21.3 years; age range: 18-24 years; 57.3% males). They completed questionnaires covering hypomania, mental toughness, symptoms of depression, physical activity, and sleep quality. Results: Higher hypomania scores were associated with higher mental toughness, increased physical activity, lower symptoms of depression and lower sleep complaints. No gender differences were observed. Higher hypomania scores were predicted by higher scores of mental toughness subscales of control and challenge, and physical activity. Conclusion: The pattern of results suggests that among a non-clinical sample of young adults, self-rated hypomania scores were associated with higher scores on mental toughness and physical activity, along with lower depression and sleep complaints. The pattern of results further suggests that hypomania traits are associated with a broad range of favorable psychological, behavioral and sleep-related traits, at least among a non-clinical sample of young adults.

  11. arXiv ARS Leptogenesis

    CERN Document Server

    Drewes, M.; Hernandez, P.; Kekic, M.; Lopez-Pavon, J.; Racker, J.; Rius, N.; Salvado, J.; Teresi, D.

    2018-02-28

    We review the current status of the leptogenesis scenario originally proposed by Akhmedov, Rubakov and Smirnov (ARS). It takes place in the parametric regime where the right-handed neutrinos are at the electroweak scale or below and the CP-violating effects are induced by the coherent superposition of different right-handed mass eigenstates. Two main theoretical approaches to derive quantum kinetic equations, the Hamiltonian time evolution as well as the Closed-Time-Path technique are presented, and we discuss their relations. For scenarios with two right-handed neutrinos, we chart the viable parameter space. Both, a Bayesian analysis, that determines the most likely configurations for viable leptogenesis given different variants of flat priors, and a determination of the maximally allowed mixing between the light, mostly left-handed, and heavy, mostly right-handed, neutrino states are discussed. Rephasing invariants are shown to be a useful tool to classify and to understand various distinct contributions to...

  12. Raising Test Scores vs. Teaching Higher Order Thinking (HOT): Senior Science Teachers' Views on How Several Concurrent Policies Affect Classroom Practices

    Science.gov (United States)

    Zohar, Anat; Alboher Agmon, Vered

    2018-01-01

    Purpose: This study investigates how senior science teachers viewed the effects of a Raising Test Scores policy and its implementation on instruction of higher order thinking (HOT), and on teaching thinking to students with low academic achievements. Background: The study was conducted in the context of three concurrent policies advocating: (a)…

  13. Small angle Ar2+ + Ar collisions

    International Nuclear Information System (INIS)

    Stevens, J.J.

    1983-01-01

    Electron capture in Ar 2+ + Ar is studied at low keV energies. Using Ar 2+ + He collisions as a calibration, it is shown that the dominant single electron capture process is endothermic and of the type Ar 2+ ( 3 P) + ArAr + ( 2 P) + Ar + (3s 2 3p 4 nI), with nI primarily being 3d and 4p. Weaker exothermic processes are also found and are due mainly to the existence of long-lived highly-excited states in the incident Ar 2+ beam. The direct scattering and double electron capture processes are also studied. Direct scattering occurs with no target excitation. Differential cross sections are presented for the collision processes. The single electron capture results are interpreted using a simple model in which a strongly attractive intermediate state couples with incident and outgoing channels

  14. In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy.

    Science.gov (United States)

    Bazzazi, Nooshin; Ahmadpanah, Mohammad; Akbarzadeh, Siamak; Seif Rabiei, Mohammad Ali; Holsboer-Trachsler, Edith; Brand, Serge

    2015-01-01

    Idiopathic central serous chorioretinopathy (CSCR) is a relatively common ophthalmic disorder characterized by the development of a serous detachment of the sensory retina. Psychophysiological factors may trigger or maintain CSCR, though, surprisingly, the association between CSCR and anxiety has yet to be studied. The aims of the present study were threefold: to determine whether 1) Iranian patients with CSCR have higher scores for anxiety, 2) anxiety is lower, if CSCR has been experienced twice, and whether 3) anxiety scores differ between sexes. A total of 30 patients with CSCR and 30 healthy age-and sex-matched controls took part in the study. A brief face-to-face interview was conducted covering demographic variables and history and occurrence of CSCR and assessing anxiety. Compared to healthy controls, anxiety was significantly higher in both first-time and second-time CSCR patients. In CSCR patients, anxiety scores did not differ between sexes. Higher anxiety scores were observed in Iranian patients with CSCR, irrespective of whether this was the first or second occurrence of CSCR. This suggests there is no psychological adaptation in terms of reduced anxiety among patients with repeated CSCR.

  15. Ar-Ar_Redux: rigorous error propagation of 40Ar/39Ar data, including covariances

    Science.gov (United States)

    Vermeesch, P.

    2015-12-01

    Rigorous data reduction and error propagation algorithms are needed to realise Earthtime's objective to improve the interlaboratory accuracy of 40Ar/39Ar dating to better than 1% and thereby facilitate the comparison and combination of the K-Ar and U-Pb chronometers. Ar-Ar_Redux is a new data reduction protocol and software program for 40Ar/39Ar geochronology which takes into account two previously underappreciated aspects of the method: 1. 40Ar/39Ar measurements are compositional dataIn its simplest form, the 40Ar/39Ar age equation can be written as: t = log(1+J [40Ar/39Ar-298.5636Ar/39Ar])/λ = log(1 + JR)/λ Where λ is the 40K decay constant and J is the irradiation parameter. The age t does not depend on the absolute abundances of the three argon isotopes but only on their relative ratios. Thus, the 36Ar, 39Ar and 40Ar abundances can be normalised to unity and plotted on a ternary diagram or 'simplex'. Argon isotopic data are therefore subject to the peculiar mathematics of 'compositional data', sensu Aitchison (1986, The Statistical Analysis of Compositional Data, Chapman & Hall). 2. Correlated errors are pervasive throughout the 40Ar/39Ar methodCurrent data reduction protocols for 40Ar/39Ar geochronology propagate the age uncertainty as follows: σ2(t) = [J2 σ2(R) + R2 σ2(J)] / [λ2 (1 + R J)], which implies zero covariance between R and J. In reality, however, significant error correlations are found in every step of the 40Ar/39Ar data acquisition and processing, in both single and multi collector instruments, during blank, interference and decay corrections, age calculation etc. Ar-Ar_Redux revisits every aspect of the 40Ar/39Ar method by casting the raw mass spectrometer data into a contingency table of logratios, which automatically keeps track of all covariances in a compositional context. Application of the method to real data reveals strong correlations (r2 of up to 0.9) between age measurements within a single irradiation batch. Propertly taking

  16. "Tristan Chords and Random Scores": Exploring Undergraduate Students' Experiences of Music in Higher Education through the Lens of Bourdieu

    Science.gov (United States)

    Moore, Gwen

    2012-01-01

    Within a theoretical framework drawn from Bourdieu, this article explores the relationship between undergraduate students' experiences of music in higher education and their musical backgrounds and prior music education experiences. More critically, this study aims to discover whether ideologies surrounding musical value impact on the student…

  17. Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor.

    Science.gov (United States)

    Louis, Elan D; Rios, Eileen; Pellegrino, Kathryn M; Jiang, Wendy; Factor-Litvak, Pam; Zheng, Wei

    2008-05-01

    Harmane (1-methyl-9H-pyrido[3,4-b]indole), a neurotoxin, may be an environmental risk factor for essential tremor (ET). Harmane and related chemicals are toxic to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease. To determine whether blood harmane concentrations correlate with olfactory test scores in patients with ET. Blood harmane concentrations were quantified using high performance liquid chromatography. Odor identification testing was performed with the University of Pennsylvania Smell Identification Test (UPSIT). In 83 ET cases, higher log blood harmane concentration was correlated with lower UPSIT score (rho=-0.46, p<0.001). 25/40 (62.5%) cases with high log blood harmane concentration (based on a median split) had low UPSIT scores (based on a median split) vs. 12/43 (27.9%) ET cases with low log blood harmane concentration (adjusted odd ratios (OR) 4.04, 95% confidence intervals (CI) 1.42-11.50, p=0.009). When compared with the low log blood harmane tertile, the odds of olfactory dysfunction were 2.64 times higher in cases in the middle tertile and 10.95 times higher in cases in the high tertile. In 69 control subjects, higher log blood harmane concentration was not correlated with lower UPSIT score (rho=0.12, p=0.32). Blood harmane concentrations were correlated with UPSIT scores in ET cases but not controls. These analyses set the stage for postmortem studies to further explore the role of harmane as a cerebellar toxin in ET.

  18. In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy

    Directory of Open Access Journals (Sweden)

    Bazzazi N

    2015-04-01

    Full Text Available Nooshin Bazzazi,1 Mohammad Ahmadpanah,2 Siamak Akbarzadeh,1 Mohammad Ali Seif Rabiei,3 Edith Holsboer-Trachsler,4 Serge Brand4,5 1Department of Ophthalmology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 2Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences; Hamadan, Iran; 3Department of Social Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 4Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland; 5Department of Sport and Health Science, Sport Science Section, University of Basel, Basel, Switzerland Introduction: Idiopathic central serous chorioretinopathy (CSCR is a relatively common ophthalmic disorder characterized by the development of a serous detachment of the sensory retina. Psychophysiological factors may trigger or maintain CSCR, though, surprisingly, the association between CSCR and anxiety has yet to be studied. The aims of the present study were threefold: to determine whether 1 Iranian patients with CSCR have higher scores for anxiety, 2 anxiety is lower, if CSCR has been experienced twice, and whether 3 anxiety scores differ between sexes.Methods: A total of 30 patients with CSCR and 30 healthy age- and sex-matched controls took part in the study. A brief face-to-face interview was conducted covering demographic variables and history and occurrence of CSCR and assessing anxiety.Results: Compared to healthy controls, anxiety was significantly higher in both first-time and second-time CSCR patients. In CSCR patients, anxiety scores did not differ between sexes.Conclusion: Higher anxiety scores were observed in Iranian patients with CSCR, irrespective of whether this was the first or second occurrence of CSCR. This suggests there is no psychological adaptation in terms of reduced anxiety among patients with repeated CSCR. Keywords: idiopathic central

  19. The origins of mental toughness – prosocial behavior and low internalizing and externalizing problems at age 5 predict higher mental toughness scores at age 14

    Directory of Open Access Journals (Sweden)

    Dena Sadeghi Bahmani

    2016-08-01

    Full Text Available Background: The concept of mental toughness has gained increasing importance among groups other than elite athletes by virtue of its psychological importance and explanatory power for a broad range of health-related behaviors. However, no study has focused so far on the psychological origins of mental toughness. Therefore, the aims of the present study were: to explore, to what extent the psychological profiles of preschoolers aged five were associated with both 1 mental toughness scores and 2 sleep disturbances at age 14, and 3 to explore possible gender differences.Method: Nine years after their first assessment at age five (preschoolers, a total of 77 adolescents (mean age: 14.35 years; SD = 1.22; 42% females took part in this follow-up study. At baseline, both parents and teachers completed the Strengths and Difficulties Questionnaire (SDQ, covering internalizing and externalizing problems, hyperactivity, negative peer relationships, and prosocial behavior. At follow-up, participants completed a booklet of questionnaires covering socio-demographic data, mental toughness, and sleep disturbances.Results: Higher prosocial behavior, lower negative peer relationships, and lower internalizing and externalizing problems at age five, as rated by parents and teachers, were associated with self-reported higher mental toughness and lower sleep disturbances at age 14. At age 14, and relative to males, females had lower MT scores and reported more sleep disturbances.Results: Higher prosocial behavior, lower negative peer relationships, and lower internalizing and externalizing problems at age five, as rated by parents and teachers, predicted self-reported higher mental toughness and lower sleep disturbances at age 14. At age 14, and relative to males, females had lower MT scores and reported more sleep disturbance.Conclusions: The pattern of results suggests that mental toughness traits during adolescence may have their origins in the pre-school years.

  20. Reference Values for the Marx Activity Rating Scale in a Young Athletic Population: History of Knee Ligament Injury Is Associated With Higher Scores.

    Science.gov (United States)

    Cameron, Kenneth L; Peck, Karen Y; Thompson, Brandon S; Svoboda, Steven J; Owens, Brett D; Marshall, Stephen W

    2015-01-01

    Activity-related patient-reported outcome measures are an important component of assessment after knee ligament injury in young and physically active patients; however, normative data for most activity scales are limited. To present reference values by sex for the Marx Activity Rating Scale (MARS) within a young and physically active population while accounting for knee ligament injury history and sex. Cross-sectional study. Level 2. All incoming freshman entering a US Service Academy in June of 2011 were recruited to participate in this study. MARS was administered to 1169 incoming freshmen (203 women) who consented to participate within the first week of matriculation. All subjects were deemed healthy and medically fit for military service on admission. Subjects also completed a baseline questionnaire that asked for basic demographic information and injury history. We calculated means with standard deviations, medians with interquartile ranges, and percentiles for ordinal and continuous variables, and frequencies and proportions for dichotomous variables. We also compared median scores by sex and history of knee ligament injury using the Kruskal-Wallis test. MARS was the primary outcome of interest. The median MARS score was significantly higher for men when compared with women (χ(2) = 13.22, df = 1, P MARS scores between men and women (χ(2) = 0.47, df = 1, P = 0.493) who reported a history of injury. Overall, median MARS scores were significantly higher among those who reported a history of knee ligament injury when compared with those who did not (χ(2) = 9.06, df = 1, P = 0.003). Assessing activity as a patient-reported outcome after knee ligament injury is important, and reference values for these instruments need to account for the influence of prior injury and sex. © 2015 The Author(s).

  1. Do later wake times and increased sleep duration of 12th graders result in more studying, higher grades, and improved SAT/ACT test scores?

    Science.gov (United States)

    Cole, James S

    2016-09-01

    The aim of this study was to investigate the relationship between sleep duration, wake time, and hours studying on high school grades and performance on the Scholastic Aptitude Test (SAT)/ American College Testing (ACT) college entrance exams. Data were collected from 13,071 recently graduated high school seniors who were entering college in the fall of 2014. A column proportions z test with a Bonferroni adjustment was used to analyze proportional differences. Analysis of covariance (ANCOVA) was used to examine mean group differences. Students who woke up prior to 6 a.m. and got less than 8 h of sleep (27 %) were significantly more likely to report studying 11 or more hours per week (30 %), almost double the rate compared to students who got more than 8 h of sleep and woke up the latest (16 %). Post hoc results revealed students who woke up at 7 a.m. or later reported significantly higher high school grades than all other groups (p students who woke up between 6:01 a.m. and 7:00 a.m. and got eight or more hours of sleep. The highest reported SAT/ACT scores were from the group that woke up after 7 a.m. but got less than 8 h sleep (M = 1099.5). Their scores were significantly higher than all other groups. This study provides additional evidence that increased sleep and later wake time are associated with increased high school grades. However, this study also found that students who sleep the longest also reported less studying and lower SAT/ACT scores.

  2. Greater Independence in Activities of Daily Living is Associated with Higher Health-Related Quality of Life Scores in Nursing Home Residents with Dementia

    Directory of Open Access Journals (Sweden)

    Charice S. Chan

    2015-06-01

    Full Text Available Health-related quality of life (HRQL for nursing home residents is important, however, the concept of quality of life is broad, encompasses many domains and is difficult to assess in people with dementia. Basic activities of daily living (ADL are measured routinely in nursing homes using the Resident Assessment Instrument-Minimum Data Set Version 2.0 (RAI-MDS and Functional Independence Measure (FIM instrument. We examined the relationship between HRQL and ADL to assess the future possibility of ADL dependency level serving as a surrogate measure of HRQL in residents with dementia. To assess ADL, measures derived from the RAI-MDS and FIM data were gathered for 111 residents at the beginning of our study and at 6-month follow-up. Higher scores for independence in ADL were correlated with higher scores for a disease-specific HRQL measure, the Quality of Life—Alzheimer’s Disease Scale. Preliminary evidence suggests that FIM-assessed ADL is associated with HRQL for these residents. The associations of the dressing and toileting items with HRQL were particularly strong. This finding suggests the importance of ADL function in HRQL. The RAI-MDS ADL scales should be used with caution to evaluate HRQL.

  3. Consumption of Low-Calorie Sweeteners among U.S. Adults Is Associated with Higher Healthy Eating Index (HEI 2005 Scores and More Physical Activity

    Directory of Open Access Journals (Sweden)

    Adam Drewnowski

    2014-10-01

    Full Text Available The possibility that low-calorie sweeteners (LCS promote lower quality diets and, therefore, weight gain has been noted as a cause for concern. Data from a representative sample of 22,231 adults were obtained from five cycles of the National Health and Nutrition Examination Survey (1999–2008 NHANES. A single 24-hour recall was used to identify consumers of LCS beverages, foods and tabletop sweeteners. Diet quality was assessed using the Healthy Eating Index 2005 (HEI 2005 and its multiple subscores. Health behaviors of interest were physical activity, smoking and alcohol use. LCS consumers had higher HEI 2005 scores than did non-consumers, largely explained by better SoFAAS subscores (solid fats, added sugar and alcohol. LCS consumers had better HEI subscores for vegetables, whole grains and low-fat dairy, but worse subscores for saturated fat and sodium compared to non-consumers. Similar trends were observed for LCS beverages, tabletop LCS and LCS foods. Consumers of LCS were less likely to smoke and were more likely to engage in recreational physical activity. LCS use was associated with higher HEI 2005 scores, lower consumption of empty calories, less smoking and more physical activity.

  4. Consumption of low-calorie sweeteners among U.S. adults is associated with higher Healthy Eating Index (HEI 2005) scores and more physical activity.

    Science.gov (United States)

    Drewnowski, Adam; Rehm, Colin D

    2014-10-17

    The possibility that low-calorie sweeteners (LCS) promote lower quality diets and, therefore, weight gain has been noted as a cause for concern. Data from a representative sample of 22,231 adults were obtained from five cycles of the National Health and Nutrition Examination Survey (1999-2008 NHANES). A single 24-hour recall was used to identify consumers of LCS beverages, foods and tabletop sweeteners. Diet quality was assessed using the Healthy Eating Index 2005 (HEI 2005) and its multiple subscores. Health behaviors of interest were physical activity, smoking and alcohol use. LCS consumers had higher HEI 2005 scores than did non-consumers, largely explained by better SoFAAS subscores (solid fats, added sugar and alcohol). LCS consumers had better HEI subscores for vegetables, whole grains and low-fat dairy, but worse subscores for saturated fat and sodium compared to non-consumers. Similar trends were observed for LCS beverages, tabletop LCS and LCS foods. Consumers of LCS were less likely to smoke and were more likely to engage in recreational physical activity. LCS use was associated with higher HEI 2005 scores, lower consumption of empty calories, less smoking and more physical activity.

  5. 40Ar/39Ar dating of pyrite

    International Nuclear Information System (INIS)

    York, D.; Masliwec, A.; Kuybida, P.; Hanes, J.A.; Hall, C.M.; Kenyon, W.J.; Spooner, E.T.C.; Scott, S.D.

    1982-01-01

    To overcome difficulties encountered in the customary method of determining the age of mineralization of sulphide ore deposits by analysing silicate material, the sulphide minerals themselves have been examined to see if they contained sufficient potassium and argon for 40 Ar/ 39 Ar age determination. Initial results indicate that this is the case for pyrite from the Geco ore body in northwestern Ontario, Canada. (U.K.)

  6. Aplicación de un score semiquantitativo de tac-ar para el control y evaluación del pronóstico de pacientes con fibrosis pulmonar idiopática

    OpenAIRE

    Peris i Sanchez, Ricardo

    2012-01-01

    Estudi prospectiu amb 36 pacients, on definírem un score semiquantitatiu per a diferents patrons de FPI a la TCAR, i la suma resultant (Score Total). Estudiàrem la relació amb paràmetres funcionals i cel.lularitat del RBA, analitzant-se'n les diferències amb els pacients morts. Trobàrem correlació entre el score de bresca (honeycomb) i total amb alguns paràmetres funcionals, prova de marxa de 6 minuts i la gasometria arterial. Els morts hi tenien major score total i tendència a la neutrofília...

  7. 40Ar-39Ar age determinations on the Owyhee basalt of the Columbia plateau

    International Nuclear Information System (INIS)

    Bottomley, R.J.; York, D.

    1976-01-01

    40 Ar/ 39 Ar step-heating analyses have been performed on 11 samples of basalt from sites near Owyhee Reservoir of southeastern Oregon, U.S.A. These rocks were extruded during the great flood basalt episode of the Pacific Northwest. The whole-rock points are highly correlated on a plot of 40 Ar/ 36 Ar versus 39 Ar/ 36 Ar, corresponding to a common age of the samples of 14.3+-0.3 m.y. Inspite of this, individual 'plateau' plots of the age versus fraction of 39 Ar released do not give good plateaux. These age spectra exhibit to varying degrees a common structure in which lower age values are found at higher temperatures. This pattern may result from a closed-system redistribution of the argon isotopes. The usefulness of grinding the basalts in removing a loosely held atmospheric argon component is confirmed. (Auth.)

  8. People reporting experiences of mediumship have higher dissociation symptom scores than non-mediums, but below thresholds for pathological dissociation [version 3; referees: 2 approved, 1 not approved

    Directory of Open Access Journals (Sweden)

    Helané Wahbeh

    2018-01-01

    Full Text Available Background: Dissociative states exist on a continuum from nonpathological forms, such as highway hypnosis and day-dreaming, to pathological states of derealization and depersonalization. Claims of communication with deceased individuals, known as mediumship, were once regarded as a pathological form of dissociation, but current definitions recognize the continuum and include distress and functional disability as symptoms of pathology. This study examined the relationship between dissociative symptoms and mediumship in a large convenience sample. Methods: Secondary analyses of cross-sectional survey data were conducted. The survey included demographics, the Dissociation Experience Scale Taxon (DES-T, score range 0-100, as well as questions about instances of mediumship experiences. Summary statistics and linear and logistic regressions explored the relationship between dissociative symptoms and mediumship endorsement. Results: 3,023 participants were included and were mostly middle-aged (51 years ± 16; range 17-96, female (70%, Caucasian (85%, college educated (88%, had an annual income over $50,000 (55%, and were raised Christian (71% but were presently described as Spiritual but not Religious (60%. Mediumship experiences were endorsed by 42% of participants, the experiences usually began in childhood (81%, and 53% had family members who reported similar experiences. The mean DES-T score across all participants was 14.4 ± 17.3, with a mean of 18.2 ± 19.3 for those claiming mediumship experiences and 11.8 ± 15.2 for those who did not (t = -10.3, p < 0.0005. The DES-T threshold score for pathological dissociation is 30. Conclusions: On average, individuals claiming mediumship experiences had higher dissociation scores than non-claimants, but neither group exceeded the DES-T threshold for pathology. Future studies exploring dissociative differences between these groups may benefit from using more comprehensive measures of dissociative symptoms

  9. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting.

    Science.gov (United States)

    Natarajan, Pradeep; Young, Robin; Stitziel, Nathan O; Padmanabhan, Sandosh; Baber, Usman; Mehran, Roxana; Sartori, Samantha; Fuster, Valentin; Reilly, Dermot F; Butterworth, Adam; Rader, Daniel J; Ford, Ian; Sattar, Naveed; Kathiresan, Sekar

    2017-05-30

    Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of 2 randomized controlled primary prevention trials (ASCOT [Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm] and JUPITER [Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin]), statin therapy led to a greater relative risk reduction among a subgroup at high genetic risk. Here, we aimed to confirm this observation in a third primary prevention randomized controlled trial. In addition, we assessed whether those at high genetic risk had a greater burden of subclinical coronary atherosclerosis. We studied participants from a randomized controlled trial of primary prevention with statin therapy (WOSCOPS [West of Scotland Coronary Prevention Study]; n=4910) and 2 observational cohort studies (CARDIA [Coronary Artery Risk Development in Young Adults] and BioImage; n=1154 and 4392, respectively). For each participant, we calculated a polygenic risk score derived from up to 57 common DNA sequence variants previously associated with coronary heart disease. We compared the relative efficacy of statin therapy in those at high genetic risk (top quintile of polygenic risk score) versus all others (WOSCOPS), as well as the association between the polygenic risk score and coronary artery calcification (CARDIA) and carotid artery plaque burden (BioImage). Among WOSCOPS trial participants at high genetic risk, statin therapy was associated with a relative risk reduction of 44% (95% confidence interval [CI], 22-60; P statin therapy was 3.6% (95% CI, 2.0-5.1) among those in the high genetic risk group and 1.3% (95% CI, 0.6-1.9) in all others. Each 1-SD increase in the polygenic risk score was associated with 1.32-fold (95% CI, 1.04-1.68) greater likelihood of having coronary artery calcification and 9.7% higher (95% CI, 2.2-17.8) burden of carotid plaque. Those at high genetic risk have a greater

  10. ScattAR

    DEFF Research Database (Denmark)

    Baldwin, Alex Dempster; Serafin, Stefania; Erkut, Cumhur

    2017-01-01

    We present an augmented reality (AR) audio application where scattering delay networks efficiently generate and organize a reverberator, based on room geometry scanned by an AR device. The application allows for real-time processing and updating of reflection path geometry. It provides a proof...

  11. Tertiary Gleason pattern in radical prostatectomy specimens is associated with worse outcomes than the next higher Gleason score group in localized prostate cancer.

    Science.gov (United States)

    Özsoy, Mehmet; D'Andrea, David; Moschini, Marco; Foerster, Beat; Abufaraj, Mohammad; Mathieu, Romain; Briganti, Alberto; Karakiewicz, Pierre I; Roupret, Morgan; Seitz, Christian; Czech, Anna Katarzyna; Susani, Martin; Shariat, Shahrokh F

    2018-04-01

    To assess the predictive value of TGP on biochemical recurrence (BCR) and its association with clinicopathological outcomes in a large, multicenter cohort of patients with localized prostate cancer (PCa) treated with radical prostatectomy (RP). Records of 6,041 patients who were treated with RP between 2000 and 2011 for clinically nonmetastatic PCa were, retrospectively, analyzed from prospectively collected datasets. BCR-free survival rates were assessed using univariable and multivariable cox-regression analyses. Median patient age was 61 years (interquartile range [IQR]: 57-66) with a median preoperative prostrate specific antigen of 6ng/ml (IQR: 4-9). Overall, 28% of patients had Gleason score (GS) 6, 0.3% GS 6 + TGP, 33% GS 7 (3 + 4), 0.2% GS 7 (3 + 4) + TGP, 22% GS 7 (4 + 3), 0.2% GS 7 (4 + 3) + TGP, 0.1% GS 8 and 0.4% GS 9 or 10. Median follow-up was 45 months (IQR: 31-57). Harboring a TGP was associated with higher rates of positive surgical margins, lymphovascular invasion, extraprostatic extension, and seminal vesicle invasion than their counterparts within the same GS group as well as in the next higher GS group (all P ≤ 0.05). At 5 years post-RP, BCR estimates were 5% for patients with GS 6, 13% for patients with GS 6 + TGP, 6% for patients with GS 7 (3 + 4), 22% for patients with GS 7 (3 + 4) + TGP, 16% for patients with GS 7 (4 + 3), 41% for patients with GS 7 (4 + 3) + TGP, 38% for patients with GS 8 (4 + 4) and 46% for patients with GS 9 or 10. Patients harboring a TGP had higher BCR rates than the patients in the next higher GS group: GS 6 + TGP vs. GS 7 (3 + 4), HR = 1.6, P = 0.02 and GS 7 (3 + 4)+TGP vs. GS 7 (4 + 3), HR = 1.4, P = 0.03. Patients with a TGP in the GS 7 (4 + 3) group had comparable BCR rates as patients with GS = 8 (P = 0.4) and GS 9 to 10 (P = 0.2). On multivariable analysis that adjusted for the effects of preoperative prostrate specific antigen, nodal involvement, positive surgical margin, extraprostatic disease (pT3a

  12. Ramon Llull's Ars Magna

    DEFF Research Database (Denmark)

    Jensen, Thessa

    2017-01-01

    might be a viable and valuable approach to understand some of the challenges and possibilities found in computer science and ethics. Vita Llull was born in 1232 in Palma de Mallorca, a melting pot for different cul-tures and religions at the time. Being educated at the king’s court, Llull learned...... of belief, life, and God as such. Computer Science? Llull was an inspiration for later scientists, most notably Giordano Bruno, Athanasius Kirchner, Agrippa of Nettesheim and Gottfried Wilhelm Leibniz, whose dissertation De Arte Combinatoria begins with a discussion of Llull’s Ars Magna. Umberto Eco also......-ple of Mallorca have since tried to have Llull canonised as a saint. Ars Magna A few years before his death Llull began to write the most thorough and final version of his Ars Magna, the Ars Generalis Ultima [3]. The books explain the different figures of the Ars, its principles, questions, descriptions...

  13. MonitAR, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop MonitAR, an Augmented Reality (AR) system that provides procedure completion guidance to astronauts. MonitAR will replace guidance from mission...

  14. Promoting an active form of learning out-of-class via answering online “study questions” leads to higher than expected exam scores in General Biology

    Directory of Open Access Journals (Sweden)

    Susan I. Gibson

    2015-10-01

    had access to the online study questions and on three to 77 exams given to students in sections that lacked such access. Data from over 1,800 students in sections with access to the online study questions show that those students scored a statistically significant average of 6.6% points higher on the exam questions analyzed than students in sections without access to the study questions. This difference was greater than the average amount necessary to raise students’ exam grades by one grade (e.g., from a “B-” to a “B”. In addition, there was a higher correlation between number of questions answered and success on exam questions on material related to the study questions than between number of questions answered and success on exam questions on material unrelated to the study questions. The online study question system required substantial effort to set up, but required minimal effort to maintain and was effective in significantly raising average exam scores for even very large course sections.

  15. Promoting an active form of learning out-of-class via answering online "study questions" leads to higher than expected exam scores in General Biology.

    Science.gov (United States)

    Gibson, Susan I

    2015-01-01

    online study questions and on three to 77 exams given to students in sections that lacked such access. Data from over 1,800 students in sections with access to the online study questions show that those students scored a statistically significant average of 6.6% points higher on the exam questions analyzed than students in sections without access to the study questions. This difference was greater than the average amount necessary to raise students' exam grades by one grade (e.g., from a "B-" to a "B"). In addition, there was a higher correlation between number of questions answered and success on exam questions on material related to the study questions than between number of questions answered and success on exam questions on material unrelated to the study questions. The online study question system required substantial effort to set up, but required minimal effort to maintain and was effective in significantly raising average exam scores for even very large course sections.

  16. DMARD use is associated with a higher risk of dementia in patients with rheumatoid arthritis: A propensity score-matched case-control study.

    Science.gov (United States)

    Chou, Ming-Hsien; Wang, Jong-Yi; Lin, Cheng-Li; Chung, Wei-Sheng

    2017-11-01

    Patients with rheumatoid arthritis (RA) exhibit an increased risk of dementia. Disease-modifying antirheumatic drugs (DMARDs) are commonly used to slow RA progression, but studies investigating the relationship between DMARDs and dementia in patients with RA are lacking. We investigated the relationship between DMARDs and dementia in patients with RA. Using the National Health Insurance Research Database, patients aged ≥20years, who were newly diagnosed with RA between 2000 and 2011 were identified. Patients with RA who had dementia comprised the dementia group, and patients with RA who did not have dementia comprised the control group. The groups were matched at a 1:1 ratio by the propensity score. DMARDs were categorized into conventional synthetic DMARDs (csDMARDs) and biological DMARDs (bDMARDs). Logistic regression models were used to calculate the odds ratio and 95% confidence interval (CI) to evaluate the association between DMARD use and the risk of dementia in patients with RA. A total of 957 patients with RA and dementia, and 957 patients with RA but not dementia, were enrolled. The risk of dementia was determined to be 1.63-fold higher in patients with RA with csDMARD use than in those without csDMARD use (95% CI=1.33-2.00). No significant risk of dementia was observed in patients with RA who used bDMARDs compared with their counterparts. However, patients with RA who used hydroxychloroquine, methotrexate, and sulfasalazine exhibited significant risks of dementia, irrespective of cumulative exposure days. Patients with RA who used csDMARDs exhibit significant association with dementia. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Simultaneous measurement of the 37Ar and 39Ar activity

    International Nuclear Information System (INIS)

    Fisenko, A.V.

    1978-01-01

    A method for simultaneous measurement of 37 Ar and 39 Ar activities, based on the different radiation penetrabilities of these isotopes is described. Two versions are realized. In the first case, a two-section detector is used whose partition partially transmits 39 Ar β-radiation and fully absorbs 37 Ar Auger electrons. A mixture of 37 Ar and 39 Ar is introduced into an internal counter operating at anticoincidences with an external counter. In the second version, a scintillation detector is used as an external counter, while the 37 Ar- 39 Ar mixture is introduced into a gas counter with a thin cathode. The rated detection efficiency of 37 Ar radiation in both versions is 80%. When measurement duration is 500 h, the sensitivity is approximately 10 -14 and 6x10 -15 Ci for 39 Ar and 37 Ar respectively

  18. Identification of excess 40Ar by the 40Ar/39Ar age spectrum technique

    International Nuclear Information System (INIS)

    Lanphere, M.A.; Dalrymple, G.B.

    1976-01-01

    40 Ar/ 39 Ar incremental heating experiments on igneous plagioclase, biotite, and pyroxene that contain known amounts of excess 40 Ar indicate that saddle-shaped age spectra are diagnostic of excess 40 Ar in igneous minerals as well as in igneous rocks. The minima in the age spectra approach but do not reach the crystallization age. Neither the age spectrum diagram nor the 40 Ar/ 36 Ar versus 39 Ar/ 36 Ar isochron diagram reliably reveal the crystallization age in such samples. (Auth.)

  19. Higher neonatal growth rate and body condition score at 7 months are predictive factors of obesity in adult female Beagle dogs.

    Science.gov (United States)

    Leclerc, Lucie; Thorin, Chantal; Flanagan, John; Biourge, Vincent; Serisier, Samuel; Nguyen, Patrick

    2017-04-13

    The risks during early growth on becoming overweight in adulthood are widely studied in humans. However, early-life predictive factors for canine adult overweight and obesity have not yet been studied. To identify factors that may help explain the development of overweight and obesity at adulthood in dogs, a longitudinal study of 2 years was conducted in 24 female Beagle dogs of the same age, sexual status, and raised under identical environmental conditions. By means of a hierarchical classification on principal components with the following quantitative values: fat-free mass (FFM), percentage fat mass and pelvic circumference at 2 years of age, three groups of dogs were established and were nominally named: ideal weight (IW, n = 9), slightly overweight (OW1, n = 6) and overweight (OW2, n = 9). With the aim of identifying predictive factors of development of obesity at adulthood parental characteristics, growth pattern, energy balance and plasma factors were analysed by logistic regression analysis. At 24 months, the group compositions were in line with the body condition scores (BCS 1-9) values of the IW (5 or 6/9), the OW1 (6/9) and the OW2 (7 or 8/9) groups. Logistic regression analysis permitted the identification of neonatal growth rate during the first 2 weeks of life (GR 2W ) and BCS at 7 months as predictors for the development of obesity at adulthood. Seventy percent of dogs with either GR 2W >125% or with BCS > 6/9 at 7 months belonged to the OW2 group. Results from energy intake and expenditure, corrected for FFM, showed that there was a greater positive energy imbalance between 7 and 10 months for the OW2, compared to the IW group. This study expands the understanding of previously reported risk factors for being overweight or obese in dogs, establishing that (i) 15 out of 24 of the studied dogs became overweight and (ii) GR 2W and BCS at 7 months of age could be used as predictive factors as overweight adult dogs in the OW2

  20. Ar + NO microwave plasmas for Escherichia coli sterilization

    Energy Technology Data Exchange (ETDEWEB)

    Hueso, Jose L; Rico, Victor J; Cotrino, Jose; Gonzalez-Elipe, Agustin R [Instituto de Ciencia de Materiales de Sevilla, Centro Mixto CSIC-Universidad de Sevilla, Centro de Investigaciones Cientificas Isla de la Cartuja, Avda. Americo Vespucio 49, 41092 Sevilla (Spain); Frias, Jose E [Instituto de BioquImica Vegetal y FotosIntesis (IBVF-CSIC). Centro de Investigaciones CientIficas Isla de la Cartuja. Avda Americo Vespucio, 49, 41092 Sevilla (Spain)], E-mail: jhueso@icmse.csic.es

    2008-05-07

    Ar + NO microwave discharges are used for sterilization and the results are compared with additional experiments with Ar, O{sub 2} and N{sub 2}-O{sub 2} plasma mixtures. The NO{sup *} species produced in the Ar-NO mixtures remain up to long distances from the source, thus improving the sterilization efficiency of the process. E. coli individuals exposed to the Ar + NO plasma undergo morphological damage and cell lysis. Combined effects of etching (by O{sup *} and Ar{sup *} species) and UV radiation (from deactivation of NO{sup *} species) are responsible for the higher activity found for this plasma mixture. (fast track communication)

  1. Ar + NO microwave plasmas for Escherichia coli sterilization

    International Nuclear Information System (INIS)

    Hueso, Jose L; Rico, Victor J; Cotrino, Jose; Gonzalez-Elipe, Agustin R; Frias, Jose E

    2008-01-01

    Ar + NO microwave discharges are used for sterilization and the results are compared with additional experiments with Ar, O 2 and N 2 -O 2 plasma mixtures. The NO * species produced in the Ar-NO mixtures remain up to long distances from the source, thus improving the sterilization efficiency of the process. E. coli individuals exposed to the Ar + NO plasma undergo morphological damage and cell lysis. Combined effects of etching (by O * and Ar * species) and UV radiation (from deactivation of NO * species) are responsible for the higher activity found for this plasma mixture. (fast track communication)

  2. Optical characteristics of a RF DBD plasma jet in various {Ar}/ {O}_{2}Ar/O2 mixtures

    Science.gov (United States)

    Falahat, A.; Ganjovi, A.; Taraz, M.; Ravari, M. N. Rostami; Shahedi, A.

    2018-02-01

    In this paper, using the optical emission spectroscopy (OES) technique, the optical characteristics of a radiofrequency (RF) plasma jet are examined. The Ar/O2 mixture is taken as the operational gas and, the Ar percentage in the Ar/O2 mixture is varied from 70% to 95%. Using the optical emission spectrum analysis of the RF plasma jet, the excitation temperature is determined based on the Boltzmann plot method. The electron density in the plasma medium of the RF plasma jet is obtained by the Stark broadening of the hydrogen Balmer H_{β }. It is mostly seen that, the radiation intensity of Ar 4p→ 4s transitions at higher argon contributions in Ar/O2 mixture is higher. It is found that, at higher Ar percentages, the emission intensities from atomic oxygen (O) are higher and, the line intensities from the argon atoms and ions including O atoms linearly increase. It is observed that the quenching of Ar^{*} with O2 results in higher O species with respect to O2 molecules. In addition, at higher percentages of Ar in the Ar/O2 mixture, while the excitation temperature is decreased, the electron density is increased.

  3. Ramon Llull's Ars Magna

    DEFF Research Database (Denmark)

    Jensen, Thessa

    2018-01-01

    The Ars Magna of Ramon Llull must be seen as one of the first attempts to formalise language, thought processes, and creating a basis for rational discussions. It consists of so-called principles, concepts, which are defined and combined through the use of four main figures. Llull's contribution...

  4. 40Ar/39Ar studies of deep sea igneous rocks

    International Nuclear Information System (INIS)

    Seidemann, D.

    1978-01-01

    An attempt to date deep-sea igneous rocks reliably was made using the 40 Ar/ 39 Ar dating technique. It was determined that the 40 Ar/ 39 Ar incremental release technique could not be used to eliminate the effects of excess radiogenic 40 Ar in deep-sea basalts. Excess 40 Ar is released throughout the extraction temperature range and cannot be distinguished from 40 Ar generated by in situ 40 K decay. The problem of the reduction of K-Ar dates associated with sea water alteration of deep-sea igneous rocks could not be resolved using the 40 Ar/ 39 Ar technique. Irradiation induced 39 Ar loss and/or redistribution in fine-grained and altered igneous rocks results in age spectra that are artifacts of the experimental procedure and only partly reflect the geologic history of the sample. Therefore, caution must be used in attributing significance to age spectra of fine grained and altered deep-sea igneous rocks. Effects of 39 Ar recoil are not important for either medium-grained (or coarser) deep-sea rocks or glasses because only a small fraction of the 39 Ar recoils to channels of easy diffusion, such as intergranular boundaries or cracks, during the irradiation. (author)

  5. Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

    International Nuclear Information System (INIS)

    Ikenberg, Kristian; Behnke, Silvia; Gerhardt, Josefine; Mortezavi, Ashkan; Wild, Peter; Hofstädter, Ferdinand; Burger, Maximilian; Moch, Holger; Kristiansen, Glen; Fritzsche, Florian R; Zuerrer-Haerdi, Ursina; Hofmann, Irina; Hermanns, Thomas; Seifert, Helge; Müntener, Michael; Provenzano, Maurizio; Sulser, Tullio

    2010-01-01

    The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed

  6. Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults.

    Science.gov (United States)

    Bettermann, Erika L; Hartman, Terryl J; Easley, Kirk A; Ferranti, Erin P; Jones, Dean P; Quyyumi, Arshed A; Vaccarino, Viola; Ziegler, Thomas R; Alvarez, Jessica A

    2018-02-01

    Both systemic redox status and diet quality are associated with risk outcomes in chronic disease. It is not known, however, the extent to which diet quality influences plasma thiol/disulfide redox status. The purpose of this study was to investigate the influence of diet, as measured by diet quality scores and other dietary factors, on systemic thiol/disulfide redox status. We performed a cross-sectional study of 685 working men and women (ages ≥18 y) in Atlanta, GA. Diet was assessed by 3 diet quality scores: the Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH), and the Mediterranean Diet Score (MDS). We measured concentrations of plasma glutathione (GSH), cysteine, their associated oxidized forms [glutathione disulfide (GSSG) and cystine (CySS), respectively], and their redox potentials (EhGSSG and EhCySS) to determine thiol/disulfide redox status. Linear regression modeling was performed to assess relations between diet and plasma redox after adjustment for age, body mass index (BMI), sex, race, and history of chronic disease. MDS was positively associated with plasma GSH (β = 0.02; 95% CI: 0.003, 0.03) and total GSH (GSH + GSSG) (β = 0.02; 95% CI: 0.003, 0.03), and inversely associated with the CySS:GSH ratio (β = -0.02; 95% CI: -0.04, -0.004). There were significant independent associations between individual MDS components (dairy, vegetables, fish, and monounsaturated fat intake) and varying plasma redox indexes (P indexes and other diet factors of interest were not significantly correlated with plasma thiol and disulfide redox measures. Adherence to the Mediterranean diet was significantly associated with a favorable plasma thiol/disulfide redox profile, independent of BMI, in a generally healthy working adult population. Although longitudinal studies are warranted, these findings contribute to the feasibility of targeting a Mediterranean diet to improve plasma redox status.

  7. Influences of atom Ar on Ar at C60 + Ar at C60 collisions

    International Nuclear Information System (INIS)

    Zhao Qiang; Zhou Hongyu; Zhang Fengshou

    2007-01-01

    A semi-emperical molecular dynamics model was developed. The central collisions of C 60 + C 60 and Ar at C 60 + Ar at C 60 at the same incident energy were investigated within this model. The fullerene dimers could be formed by a self-assembly of C 60 fullerene, and the new fullerene structure like 'peanut' could be formed by a self-assembly of Ar at C 60 . It was found that atom Ar had a great effect on the collision of Ar at C 60 + Ar at C 60 . (authors)

  8. Shorter sleep duration is associated with higher energy intake and an increase in BMI z-score in young children predisposed to overweight

    DEFF Research Database (Denmark)

    Rangan, A.; Zheng, M.; Olsen, N. J.

    2018-01-01

    in a group of young obesity-predisposed children, and to assess whether intakes of energy or macronutrients mediate this relationship. Methods: Participants included 368 Danish children aged 2–6 years from the Healthy Start Study, a 1.3 year randomised controlled intervention trial. Sleep habits were...... was 10.7 h (range 8.8–12.5 h). After controlling for potential confounders, a significant inverse association between nighttime sleep duration and ΔBMI z-score (β=−0.090, P=0.046) was observed. This relationship was mediated by energy intake, with all macronutrients contributing to this mediation effect...

  9. Ars Electronica tulekul / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2003-01-01

    6.-11. IX toimub Austrias Linzis "Ars Electronica" festival, mille teema on "Code - The Language of Our Time". Festivali kavast, osalejatest, ava-performance'ist "Europe - A Symphonic Vision", näitusest "Cyberarts 2003. Prix Ars Electronica"

  10. ARABIC LIGHT STEMMER (ARS

    Directory of Open Access Journals (Sweden)

    ASMA AL-OMARI

    2014-12-01

    Full Text Available Stemming is a main step used to process textual data. It is usually used in several types of applications such as: text mining, information retrieval (IR, and natural language processing (NLP. A major task in stemming is to standardize words; which can be achieved by reducing each word to its base (root or stem. Arabic stemming is not an easy task. Unlike other languages, Arabic language is a highly inflected language, since it uses many inflectional forms. Researchers are divided on the benefit of using stemming in fields of IR, NLP...etc., since in Arabic the morphological variants of a certain word are not always semantically related. The aim of this paper is to design and implement a new Arabic light stemmer (ARS which is not based on Arabic root patterns. Instead, it depends on well defined mathematical rules and several relations between letters. A series of tests were conducted on ARS stemmer to compare its effectiveness with the effectiveness of two other Arabic stemmers. Test shows clearly the effectiveness superiority of ARS compared to effectiveness of these two Arabic stemmers.

  11. Temperature and pressure effects on 40Ar-39Ar systematics

    International Nuclear Information System (INIS)

    Ozima, M.; Kaneoka, I.; Yanagisawa, M.

    1979-01-01

    The effects of thermal and compressional treatment on 40 Ar- 39 Ar systematics have been investigated on three artificially heated biotite samples (heated for 1 hour at 700 0 C and 860 0 C in air and 700 0 C in vacuum respectively) and uniaxially compressed granite (p=1400 bar) and basalt samples (p=1660 bar). The 40 Ar- 39 Ar results for the disturbed samples are compared with those for undisturbed samples. Except for the vacuum-heating case, the effects of the disturbances may be interpreted as the combined effect of a partial loss of radiogenic 40 Ar from the sample and an incorporation of air Ar into the sample. Common diagnostic effects are (1) reduction of the total fusion age, (2) distortion of the age spectrum and, if the degree of the partial Ar loss is small (3) approximate preservation of the isochron age, and (4) reduction of the intercept value ( 40 Ar/ 36 Ar) in the isochron plot. The features observed in the age spectra of artificially disturbed samples are rather common in geologically disturbed samples, suggesting that the artificial disturbances simulate the effects of geological disturbances on 40 Ar- 39 Ar systematics. (Auth.)

  12. Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores

    Directory of Open Access Journals (Sweden)

    Mortezavi Ashkan

    2010-06-01

    Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

  13. Spectroanalytical investigations on inductively coupled N2/Ar and Ar/Ar high frequency plasmas

    International Nuclear Information System (INIS)

    Malinowski, P.; Mazurkiewicz, M.; Nickel, H.

    1981-03-01

    In order to improve the detection limits of trace elements in corrosion products of metallic materials, the inductively coupled plasma excitation source (ICP) was applied for spectroscopic analysis. Besides optimizing the working conditions for the mentioned materials, the fundamental research clearing the excitation processes in ICP was carried out. Basicly, two plasma systems were investigated: the nitrogen cooled N 2 /Ar- and pure Ar/Ar-plasma. The computed detection limits for 8 chosen elements are between 0.1 and 50 μg ml -1 in both plasmas. The advantage of ion lines was clearly present; in N 2 /Ar-plasma it was larger than in Ar/Ar-plasma. The excitation temperatures measured with help of ArI, FeI and ZnI lines rise with increasing power and decreasing distance from the induction coil. The distribution of Zn excitation temperature in N 2 /Ar-plasma as well as the measured N + 2 rotational and CN vibrational temperatures indicate, that the toroidal structure of Ar/Ar-plasma is not analogue to the N 2 /Ar-plasma. The values of the various excitation temperatures (Ar, Fe, Zn) and the differences between the excitation, vibration, rotation and ionization temperatures (Tsub(i) > Tsub(n) = Tsub(vib) > Tsub(rot)) indicate an absence of thermal equilibrium in the concerned system. (orig.)

  14. The Zhongshan Score

    Science.gov (United States)

    Zhou, Lin; Guo, Jianming; Wang, Hang; Wang, Guomin

    2015-01-01

    Abstract In the zero ischemia era of nephron-sparing surgery (NSS), a new anatomic classification system (ACS) is needed to adjust to these new surgical techniques. We devised a novel and simple ACS, and compared it with the RENAL and PADUA scores to predict the risk of NSS outcomes. We retrospectively evaluated 789 patients who underwent NSS with available imaging between January 2007 and July 2014. Demographic and clinical data were assessed. The Zhongshan (ZS) score consisted of three parameters. RENAL, PADUA, and ZS scores are divided into three groups, that is, high, moderate, and low scores. For operative time (OT), significant differences were seen between any two groups of ZS score and PADUA score (all P RENAL showed no significant difference between moderate and high complexity in OT, WIT, estimated blood loss, and increase in SCr. Compared with patients with a low score of ZS, those with a high or moderate score had 8.1-fold or 3.3-fold higher risk of surgical complications, respectively (all P RENAL score, patients with a high or moderate score had 5.7-fold or 1.9-fold higher risk of surgical complications, respectively (all P RENAL and PADUA scores. ZS score could be used to reflect the surgical complexity and predict the risk of surgical complications in patients undergoing NSS. PMID:25654399

  15. 40Ar/39Ar age calibration against counted annuallayers

    DEFF Research Database (Denmark)

    Storey, Michael; Stecher, Ole

    2008-01-01

    The 40Ar/39Ar method, based on the decay of the naturally occurring radioactive isotope 40K, is capable of producing ages with precision better than ± 0.1 %. However, accuracy is limited to no better than 1 % mainly due to the relatively large uncertainty in the 40K decay constants. One approach...... worth exploring for an improved absolute age basis for the 40Ar/39Ar system is through cross-calibration with counted annual layers (e.g. tree rings, varves and ice cores). North Atlantic Ash Zone (NAAZ) II is found within the dated part of the annual Greenland ice core record. NAAZ II has been...... correlated to the Icelandic peralkaline rhyolitic Thorsmörk ignimbrite. We will present preliminary 40Ar/39Ar results on the age of this eruption...

  16. Geochronology and thermochronology by the 40Ar/39Ar method

    International Nuclear Information System (INIS)

    McDougall, I.; Harrison, T.M.

    1988-01-01

    This work is a response to the authors' belief that there is a need for a monograph on 40 Ar/ 39 Ar dating to provide concise knowledge concerning the application of this method to geological studies. They aim to provide a reasonably comprehensive but by no means exhaustive coverage of the principles and practices of 40 Ar/ 39 Ar dating, with emphasis on interpretation of results. In attempting to provide an overview of the current state of knowledge, they commonly cite examples from the available literature. They draw rather heavily upon their own work, because they feel comfortable with their own examples. (author)

  17. Geological Dating by 40 Ar - 39 Ar method

    International Nuclear Information System (INIS)

    Vollbert Romero, M.E.

    1992-01-01

    The isotope 40 K is radioactive, it decays to 40 Ar stable. The number of 40 Ar atoms produced from 40 K, permits to calculate the date of rocks and minerals. This dating technique is named 'Conventional K-Ar Dating Method'. The 40 Ar - 39 Ar dating method permits to calculate the age of rocks and minerals eliminating the limitation of the K-Ar method by calculating potassium and argon concentrations in a single measurement of the ratio of argon isotopes. In this work, the irradiation of the sample with fast neutrons in the nuclear reactor was established. 39 Ar is obtained from the induced reaction 39 K (n,p) 39 Ar. Thus the ration of 40 Ar - 39 Ar allows to obtain the date of rocks and minerals. This ratio was measured in a mass spectrometer. If the measurement of argon concentration in the sample is carried out at different increasing temperature values, it is possible to get information of paleotemperatures. The number of atoms 39 Ar is a function of the number 39 K atoms, irradiation time, neutrons flux, its energy E and the capture cross section σ of 39 K. These parameters are calculate indirectly by obtaining the so called 'J value ' by using a standard mineral with known age (HD-BI y Biot-133), this mineral is irradiated together with the unknown age sample. The values of 'J' obtained are in the interval of 2.85 a 3.03 (x 10 - 3)J/h. Rocks from 'Tres Virgenes' were dated by the method described in this work, showing an agreement with previous values of different authors. The age of this rocks are from Cenozoico era, mainly in the miocene period. (Author)

  18. 40Ar/39Ar geochronology of terrestrial pyroxene

    Science.gov (United States)

    Ware, Bryant; Jourdan, Fred

    2018-06-01

    Geochronological techniques such as U/Pb in zircon and baddeleyite and 40Ar/39Ar on a vast range of minerals, including sanidine, plagioclase, and biotite, provide means to date an array of different geologic processes. Many of these minerals, however, are not always present in a given rock, or can be altered by secondary processes (e.g. plagioclase in mafic rocks) limiting our ability to derive an isotopic age. Pyroxene is a primary rock forming mineral for both mafic and ultramafic rocks and is resistant to alteration process but attempts to date this phase with 40Ar/39Ar has been met with little success so far. In this study, we analyzed pyroxene crystals from two different Large Igneous Provinces using a multi-collector noble gas mass spectrometer (ARGUS VI) since those machines have been shown to significantly improve analytical precision compared to the previous single-collector instruments. We obtain geologically meaningful and relatively precise 40Ar/39Ar plateau ages ranging from 184.6 ± 3.9 to 182.4 ± 0.8 Ma (2σ uncertainties of ±1.8-0.4%) and 506.3 ± 3.4 Ma for Tasmanian and Kalkarindji dolerites, respectively. Those data are indistinguishable from new and/or published U-Pb and 40Ar/39Ar plagioclase ages showing that 40Ar/39Ar dating of pyroxene is a suitable geochronological tool. Scrutinizing the analytical results of the pyroxene analyses as well as comparing them to the analytical result from plagioclase of the same samples indicate pure pyroxene was dated. Numerical models of argon diffusion in plagioclase and pyroxene support these observations. However, we found that the viability of 40Ar/39Ar dating approach of pyroxene can be affected by irradiation-induced recoil redistribution between thin pyroxene exsolution lamellae and the main pyroxene crystal, hence requiring careful petrographic observations before analysis. Finally, diffusion modeling show that 40Ar/39Ar of pyroxene can be used as a powerful tool to date the formation age of mafic

  19. Influence of Ar addition on ozone generation in nonthermal plasmas

    International Nuclear Information System (INIS)

    Chen, Hsin Liang; Lee, How Ming; Chen, Shiaw Huei; Wei, Ta Chin; Chang, Moo Been

    2010-01-01

    Inconsistency regarding the influence of Ar addition on ozone generation in a corona discharge has been found in relevant studies. Unlike in the literature to date, a dielectric barrier discharge (DBD) reactor is adopted in this study. In addition to clarifying whether using Ar as an additive would lead to different types of behavior in a DBD and a corona discharge, this study is also motivated to explore the possible causes leading to the inconsistency. The experimental results show that adding Ar into the O 2 plasma would lead to the same influence on ozone generation in the DBD and corona discharge. Moreover, all types of controversial behavior caused by Ar addition reported in the relevant literature are observed in this study as well, indicating that the results of this study are comprehensive enough to interpret the inconsistency. By examining the experimental results in detail, it is found that the controversial influences of Ar addition on ozone generation were found using different assumptions. At a fixed applied voltage, the ozone generation might increase as the Ar concentration is increased, which results from a higher discharge power. Nevertheless, for a certain specific input energy (the ratio of discharge power to gas flow rate), the ozone concentration is lower as the Ar concentration is increased. Therefore, adding Ar is not a good way to enhance ozone generation from an economic point of view.

  20. Characterization of a novel androgen receptor (AR) coregulator RIPK1 and related chemicals that suppress AR-mediated prostate cancer growth via peptide and chemical screening.

    Science.gov (United States)

    Hsu, Cheng-Lung; Liu, Jai-Shin; Lin, Ting-Wei; Chang, Ying-Hsu; Kuo, Yung-Chia; Lin, An-Chi; Ting, Huei-Ju; Pang, See-Tong; Lee, Li-Yu; Ma, Wen-Lung; Lin, Chun-Cheng; Wu, Wen-Guey

    2017-09-19

    Using bicalutamide-androgen receptor (AR) DNA binding domain-ligand binding domain as bait, we observed enrichment of FxxFY motif-containing peptides. Protein database searches revealed the presence of receptor-interacting protein kinase 1 (RIPK1) harboring one FxxFY motif. RIPK1 interacted directly with AR and suppressed AR transactivation in a dose-dependent manner. Domain mapping experiments showed that the FxxFY motif in RIPK1 is critical for interactions with AR and the death domain of RIPK1 plays a crucial role in its inhibitory effect on transactivation. In terms of tissue expression, RIPK1 levels were markedly higher in benign prostate hyperplasia and non-cancerous tissue regions relative to the tumor area. With the aid of computer modeling for screening of chemicals targeting activation function 2 (AF-2) of AR, we identified oxadiazole derivatives as good candidates and subsequently generated a small library of these compounds. A number of candidates could effectively suppress AR transactivation and AR-related functions in vitro and in vivo with tolerable toxicity via inhibiting AR-peptide, AR-coregulator and AR N-C interactions. Combination of these chemicals with antiandrogen had an additive suppressive effect on AR transcriptional activity. Our collective findings may pave the way in creating new strategies for the development and design of anti-AR drugs.

  1. ARS-Media for excel instruction manual

    Science.gov (United States)

    ARS-Media for Excel Instruction Manual is the instruction manual that explains how to use the Excel spreadsheet ARS-Media for Excel application. ARS-Media for Excel Instruction Manual is provided as a pdf file....

  2. Electron scattering from 36Ar and 40Ar

    International Nuclear Information System (INIS)

    Finn, J.M.

    1975-01-01

    The argon isotopes, 36 Ar and 40 Ar, have been investigated using electron scattering at the high-resolution Linac facilities of the National Bureau of Standards. Both elastic scattering and scattering to low-lying states have been observed. A high-pressure, low-volume gas target cell was designed and developed for this experiment. The cell features a transmission geometry and has resolution comparable to solid targets. Spectra were obtained at incident beam energies ranging from 65 to 115 MeV at scattering angles of 92.5 0 and 110 0 . Values obtained for the rms charge radii are 3.327 +- 0.015 and 3.393 +- 0.015 fm for 36 Ar and 40 Ar respectively. A sensitive measurement was made of the difference in the two radii yielding a value of Δ r = 0.079 +- 0.006 fm. The inelastic levels observed are the 1.97 (2 + ) and 4.18 MeV (3 - ) levels in 36 Ar, and the 1.46 (2 + ), 2.52 (2 + ), 3.21 (2 + ), and 3.68 MeV (3 - ) levels in 40 Ar. A Tassie model analysis was made of the inelastic transitions in the DWBA approximation and transition strengths of these levels were extracted

  3. Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia, Is Associated with Higher Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population.

    Science.gov (United States)

    Rau, Cheng-Shyuan; Wu, Shao-Chun; Chen, Yi-Chun; Chien, Peng-Chen; Hsieh, Hsiao-Yun; Kuo, Pao-Jen; Hsieh, Ching-Hua

    2017-11-03

    Background : Admission hyperglycemia is associated with higher morbidity and mortality in patients with traumatic brain injury (TBI). Stress-induced hyperglycemia (SIH), a form of hyperglycemia induced by the stress response, is associated with increased patient mortality following TBI. However, admission hyperglycemia occurs not only in SIH but also in patients with diabetic hyperglycemia (DH). Current information regarding whether trauma patients with SIH represent a distinct group with differential outcomes compared to those with DH remains limited. Methods : Serum glucose concentration ≥200 mg/dL upon arrival at the emergency department was defined as hyperglycemia. Presence of diabetes mellitus (DM) was determined by patient history and/or admission glycated hemoglobin (HbA1c) level ≥6.5%. In the present study, the patient cohort included those with moderate and severe TBI, as defined by an Abbreviated Injury Scale (AIS) score ≥3 points in the head, and excluded those who had additional AIS scores ≥3 points in any other region of the body. A total of 1798 adult patients with isolated moderate to severe TBI were allocated into four groups: SIH ( n = 140), DH ( n = 187), diabetic normoglycemia (DN, n = 186), and non-diabetic normoglycemia (NDN, n = 1285). Detailed patient information was retrieved from the Trauma Registry System at a level I trauma center between 1 January 2009, and 31 December 2015. Unpaired Student's t - and Mann-Whitney U -tests were used to analyze normally and non-normally distributed continuous data, respectively. Categorical data were compared using the Pearson chi-square or two-sided Fisher's exact tests. Matched patient populations were allocated in a 1:1 ratio according to propensity scores calculated by NCSS software. Logistic regression was used to evaluate the effect of SIH and DH on the adjusted mortality outcome. Results : In patients with isolated moderate to severe TBI, the presence of SIH and DH led to 9.1-fold and 2

  4. The ArDM experiment

    CERN Document Server

    Haranczyk, M; Badertscher, A; Boccone, V; Bourgeois, N; Bueno, A; Carmona-Benitez, M C; Chorowski, M; Creus, W; Curioni, A; Daw, E; Degunda, U; Dell'Antone, A; Droge, M; Epprecht, L; Haller, C; Horikawa, S; Kaufmann, L; Kisiel, J; Knecht, L; Laffranchi, M; Lagoda, J; Lazzaro, C; Lightfoot, P; Lozano, J; Lussi, D; Maire, G; Mania, S; Marchionni, A; Mavrokoridis, K; Melgarejo, A; Mijakowski, P; Natterer, G; Navas-Concha, S; Otiougova, P; Piotrowska, A; Polinski, J; de Prado, M; Przewlocki, P; Ravat, S; Regenfus, C; Resnati, F; Robinson, M; Rochet, J; Romero, L; Rondio, E; Rubbia, A; Scotto-Lavina, L; Spooner, N; Viant, T; Trawinski, A; Ulbricht, J; Zalewska, A

    2010-01-01

    The aim of the ArDM project is the development and operation of a one ton double-phase liquid argon detector for direct Dark Matter searches. The detector measures both the scintillation light and the ionization charge from ionizing radiation using two independent readout systems. This paper briefly describes the detector concept and presents preliminary results from the ArDM R&D program, including a 3 l prototype developed to test the charge readout system.

  5. Reevaluation of the Solar Wind 36Ar/38Ar Ratio

    Science.gov (United States)

    Becker, R. H.; Schlutter, D. J.; Rider, P. E.; Pepin, R. O.

    1996-03-01

    The isotopic composition of solar wind (SW) argon is an important parameter in the modeling of the evolution of the terrestrial planet atmospheres. Anders and Grevesse assumed a 36Ar/38Ar ratio for SW of 5.31, essentially equal to that of air. Considerable evidence has since developed which indicates that this ratio is too low. Benkert et al. have reported their best estimate for the recent SW as 5.48 +/- 0.05, determined from measurements of lunar soil 71501. Based on Ar data obtained from surface oxidation of a metal separate from the Weston meteorite and from an uncontrolled etch of lunar sample 67701, reported by our group previously, we consider even this value to be too low. Since values of 5.75 to 5.85 were reported by Black for initial low temperature (fairly high SW 36Ar/38Ar ratio (in the range of ~5.6 to ~5.7), we decided to analyze Kapoeta for its light solar wind gases using the acid-etching techniques developed in our laboratory based on the CSSE procedure of Benkert et al.

  6. Ar-Ar dating techniques for terrestrial meteorite impacts

    Science.gov (United States)

    Kelley, S. P.

    2003-04-01

    The ages of the largest (>100 km) known impacts on Earth are now well characterised. However the ages of many intermediate sized craters (20-100 km) are still poorly known, often the only constraints are stratigraphic - the difference between the target rock age and the age of crater filling sediments. The largest impacts result in significant melt bodies which cool to form igneous rocks and can be dated using conventional radiometric techniques. Smaller impacts give rise to thin bands of melted rock or melt clasts intimately mixed with country rock clasts in breccia deposits, and present much more of a challenge to dating. The Ar-Ar dating technique can address a wide variety of complex and heterogeneous samples associated with meteorite impacts and obtain reasonable ages. Ar-Ar results will be presented from a series of terrestrial meteorite impact craters including Boltysh (65.17±0.64 Ma, Strangways (646±42 Ma), and St Martin (220±32 Ma) and a Late Triassic spherule bed, possibly representing distal deposits from Manicouagan (214±1 Ma) crater. Samples from the Boltysh and Strangways craters demonstrate the importance of rapid cooling upon the retention of old ages in glassy impact rocks. A Late Triassic spherule bed in SW England is cemented by both carbonate and K-feldspar cements allowing Ar-Ar dating of fine grained cement to place a mimimum age upon the age of the associated impact. An age of 214.7±2.5 Ma places the deposit with errors of the age of the Manicouagan impact, raising the possibility that it may represent a distal deposit (the deposit lay around 2000 km away from the site of the Manicouagan crater during the Late Triassic). Finally the limits of the technique will be demonstrated using an attempt to date melt rocks from the St Martin Crater in Canada.

  7. Feldspar 40Ar/39Ar dating of ICDP PALEOVAN cores

    Science.gov (United States)

    Engelhardt, Jonathan Franz; Sudo, Masafumi; Stockhecke, Mona; Oberhänsli, Roland

    2017-11-01

    Volcaniclastic fall deposits in ICDP drilling cores from Lake Van, Turkey, contain sodium-rich sanidine and calcium-rich anorthoclase, which both comprise a variety of textural zoning and inclusions. An age model records the lake's history and is based on climate-stratigraphic correlations, tephrostratigraphy, paleomagnetics, and earlier 40Ar/39Ar analyses (Stockhecke et al., 2014b). Results from total fusion and stepwise heating 40Ar/39Ar analyses presented in this study allow for the comparison of radiometric constraints from texturally diversified feldspar and the multi-proxy lacustrine age model and vice versa. This study has investigated several grain-size fractions of feldspar from 13 volcaniclastic units. The feldspars show textural features that are visible in cathodoluminescence (CL) or back-scattered electron (BSE) images and can be subdivided into three dominant zoning-types: (1) compositional zoning, (2) round pseudo-oscillatory zoning and (3) resorbed and patchy zoning (Ginibre et al., 2004). Round pseudo-oscillatory zoning records a sensitive alternation of Fe and Ca that also reflects resorption processes. This is only visible in CL images. Compositional zoning reflects anticorrelated anorthite and orthoclase contents and is visible in BSE. Eleven inverse isochron ages from total fusion and three from stepwise heating analyses fit the age model. Four experiments resulted in older inverse isochron ages that do not concur with the model within 2σ uncertainties and that deviate from 1 ka to 17 ka minimum. C- and R-type zoning are interpreted as representing growth in magma chamber cupolas, as wall mushes, or in narrow conduits. Persistent compositions of PO-type crystals and abundant surfaces recording dissolution features correspond to formation within a magma chamber. C-type zoning and R-type zoning have revealed an irregular incorporation of melt and fluid inclusions. These two types of zoning in feldspar are interpreted as preferentially

  8. A pulsed plasma jet with the various Ar/N2 mixtures

    Science.gov (United States)

    Barkhordari, A.; Ganjovi, A.; Mirzaei, I.; Falahat, A.; Rostami Ravari, M. N.

    2017-12-01

    In this paper, using the Optical Emission Spectroscopy technique, the physical properties of a fabricated pulsed DBD plasma jet are studied. Ar/N2 gaseous mixture is taken as operational gas, and Ar contribution in Ar/N2 mixture is varied from 75 to 95%. Through the optical emission spectra analysis of the pulsed DBD plasma jet, the rotational, vibrational and excitation temperatures and density of electrons in plasma medium of the pulsed plasma jet are obtained. It is seen that, at the wavelength of 750.38 nm, the radiation intensity from the Ar 4p → 4 s transition increases at the higher Ar contributions in Ar/N2 mixture. It is found that, for 95% of Ar presence in the mixture, the emission intensities from argon and molecular nitrogen are higher, and the emission line intensities will increase nonlinearly. In addition, it is observed that the quenching of Ar* by N2 results in the higher intensities of N2 excited molecules. Moreover, at the higher percentages of Ar in Ar/N2 mixture, while all the plasma temperatures are increased, the plasma electron density is reduced.

  9. Analysis list: Ar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Ar Gonad,Kidney,Prostate + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/targe...t/Ar.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Ar.5.tsv http://dbarchive.biosciencedbc.jp/...kyushu-u/mm9/target/Ar.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Ar.Gonad.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Ar.Kidney.tsv,http://dbarchive.bioscienced...bc.jp/kyushu-u/mm9/colo/Ar.Prostate.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Gonad.gml,http://dbarchive.bioscience

  10. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians12

    Science.gov (United States)

    Fretts, Amanda M; Follis, Jack L; Nettleton, Jennifer A; Lemaitre, Rozenn N; Ngwa, Julius S; Wojczynski, Mary K; Kalafati, Ioanna Panagiota; Varga, Tibor V; Frazier-Wood, Alexis C; Houston, Denise K; Lahti, Jari; Ericson, Ulrika; van den Hooven, Edith H; Mikkilä, Vera; Kiefte-de Jong, Jessica C; Mozaffarian, Dariush; Rice, Kenneth; Renström, Frida; North, Kari E; McKeown, Nicola M; Feitosa, Mary F; Kanoni, Stavroula; Smith, Caren E; Garcia, Melissa E; Tiainen, Anna-Maija; Sonestedt, Emily; Manichaikul, Ani; van Rooij, Frank JA; Dimitriou, Maria; Raitakari, Olli; Pankow, James S; Djoussé, Luc; Province, Michael A; Hu, Frank B; Lai, Chao-Qiang; Keller, Margaux F; Perälä, Mia-Maria; Rotter, Jerome I; Hofman, Albert; Graff, Misa; Kähönen, Mika; Mukamal, Kenneth; Johansson, Ingegerd; Ordovas, Jose M; Liu, Yongmei; Männistö, Satu; Uitterlinden, André G; Deloukas, Panos; Seppälä, Ilkka; Psaty, Bruce M; Cupples, L Adrienne; Borecki, Ingrid B; Franks, Paul W; Arnett, Donna K; Nalls, Mike A; Eriksson, Johan G; Orho-Melander, Marju; Franco, Oscar H; Lehtimäki, Terho; Dedoussis, George V; Meigs, James B; Siscovick, David S

    2015-01-01

    Background: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown. Objective: We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus. Design: Fourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined 1) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations. Results: Processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049–ln-pmol/L (95% CI: 0.035, 0.063–ln-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic

  11. Alignment and orientation of Ar+ in He+-Ar collisions

    International Nuclear Information System (INIS)

    Moudry, B.W.; Yenen, O.; Jaecks, D.H.

    1994-01-01

    We have measured the alignment and orientation parameters of the 2 F 7/2 0 and 2 F 5/2 0 states of Ar + formed in the two-electron process; He + +Ar→He(1s 2 )+Ar + (3p 4 4p'). These have been measured at a collision energy of 0.25 keV/amu and for scattering angles ranging from 0.94 to 3.75 . First, by comparing the orientation prameter for the Ar + [(3p 4 [ 1 D]4p' 2 F 7/2 0 ] and the Ar + [(3p 4 [ 1 D]4p' 2 F 5/2 0 ] states, we have experimentally determined the importance of the spin-dependent interactions for the present collision system, by testing the Percival-Seaton hypothesis of spin independence. If the Percival-Seaton hypothesis holds for this system, the orientation parameter should be J-independent. Secondly, the magnitude of the orientation prameter can be interpreted as resulting from the collective circulation of the unexcited 3p 4 electrons and the excited 4p electron. The direction of this collective circulation is compared to the propensity rule for colliding di-atom systems. (orig.)

  12. Ar-39/Ar-40 systematics of Allende inclusions

    International Nuclear Information System (INIS)

    Herzog, G.F.; Rutgers University, New Brunswick, NJ); Bence, A.E.

    1980-01-01

    A laser microprobe was used to measure the Ar isotopic contents of individual mineral grains in four neutron-irradiated Allende samples: two coarse-grained Ca-Al-rich inclusions, one fine-grained Ca-Al-rich inclusion, and one sample with matrix and miscellaneous chondrules. The following K-Ar ages (G.y.) were obtained after degassing low Ar retentive sites by preheating the samples for one hour at 675 C: matrix, 3.5 + or - 0.2 three miscellaneous chondrules, 4.4 + or - 0.1, 4.0 + or - 0.1, and 4.4 + or - 0.1 and the fine-grained inclusion, 4.5 + or - 0.2. The minerals in the coarse-grained Ca-Al-rich inclusions have ubiquitous chlorine, less than 10 ppm K and apparent ages ranging upwards from 4.6 G.y. to well over 10 G.y. Possible explanations for these apparent ages are atmospheric contamination, the decay of K-40 prior to the formation of the solar system, and the trapping of radiogenic Ar-40 lost by the matrix

  13. Determination of Ar metastable atom densities in Ar and Ar/H2 inductively coupled low-temperature plasmas

    International Nuclear Information System (INIS)

    Fox-Lyon, N; Knoll, A J; Oehrlein, G S; Franek, J; Demidov, V; Koepke, M; Godyak, V

    2013-01-01

    Ar metastable atoms are important energy carriers and surface interacting species in low-temperature plasmas that are difficult to quantify. Ar metastable atom densities (N Ar,m ) in inductively coupled Ar and Ar/H 2 plasmas were obtained using a model combining electrical probe measurements of electron density (N e ) and temperature (T e ), with analysis of spectrally resolved Ar plasma optical emission based on 3p → 1s optical emission ratios of the 419.8 nm line to the 420.1 nm line. We present the variation of N Ar,m as the Ar pressure and the addition of H 2 to Ar are changed comparatively to recent adsorption spectroscopy measurements. (paper)

  14. A Pilot Study Providing Evidence for a Relationship between a Composite Lifestyle Score and Risk of Higher Carotid Intima-Media Thickness: Is There a Link to Oxidative Stress?

    Directory of Open Access Journals (Sweden)

    Neda Seyedsadjadi

    2018-01-01

    Full Text Available Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS and the development of cardiovascular disease (CVD. Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS and carotid intima-media thickness (CIMT, a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ29=35.60, P≤0.001. The adjusted model explained 42.4% of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR=3.60, 95% CI: 1.19–10.88, P=0.023. Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC (r99=0.28, P=0.006, hydroperoxide (HPX (rs99=−0.28, P=0.005, TAC/HPX ratio (r98=0.41, P≤0.001, γ-glutamyltransferase (r97=−0.23, P=0.024, uric acid (r98=−0.20, P=0.045, and inflammatory C-reactive protein (rs97=−0.25, P=0.012 and interleukin-1β (r97=−0.21, P=0.040. These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.

  15. Standardization of 40Ar-39Ar dating facility at KDMIPE, ONGC, Dehradun

    International Nuclear Information System (INIS)

    Rathore, S.S.; Singh, M.P.; Vijan, A.R.; Bansal, M.; Prabhu, B.N.; Misra, K.N.

    2003-01-01

    In the pursuit of acquiring state of the art technology, efforts were being made for last more than two years to establish 40 Ar- 39 Ar dating facility at KDMIPE. The 40 Ar- 39 Ar dating technique is an analytical conversion of the conventional K-Ar dating method. In this method, the sample to be dated is first irradiated in a nuclear reactor to transform a portion of 39 K to 39 Ar by the fast neutron reaction i.e. 39 K(n, p) 39 Ar. After irradiation, the sample is placed in an ultra-high vacuum system and the argon extracted from it by fusion is purified and analyzed isotopically in a mass spectrometer. The relative abundances of 40 Ar, 39 Ar, 37 Ar and 36 Ar are measured. The 40 Ar/ 39 Ar K is determined, where 40 Ar is the radiogenic argon, and 39 Ar K is the 39 Ar produced from 39 K during the irradiation. The 40 Ar/ 39 Ar K ratio is proportional to the 40 Ar/ 40 K ratio in the sample and, therefore, is proportional to age

  16. AR DOC: Augmented reality documentaries

    DEFF Research Database (Denmark)

    Vistisen, Peter

    2014-01-01

    Augmented Reality Documentaries (AR DOC) er et ’lille’ Shareplay projekt (ansøgte midler augmented reality cross media løsninger, til at skabe engagerende publikumsformidling...... indenfor oplevelsesindustrien. Projektet har genereret ny viden omkring, hvordan fysisk og digital formidling kan understøttes via Augmented Reality som formidlingsformat....

  17. ARS-Media for Excel

    Science.gov (United States)

    ARS-Media for Excel is an ion solution calculator that uses Microsoft Excel to generate recipes of salts for complex ion mixtures specified by the user. Generating salt combinations (recipes) that result in pre-specified target ion values is a linear programming problem. Thus, the recipes are genera...

  18. "Ars Electronica 2009" / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2009-01-01

    30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

  19. Kinetics of Ar isotopes during neutron irradiation: 39Ar loss from minerals as a source of error in 40Ar/39Ar dating

    International Nuclear Information System (INIS)

    Hess, J.C.; Lippolt, H.J.

    1986-01-01

    The loss of 39 Ar from minerals in the course of neutron activation for 40 Ar/ 39 Ar dating is studied by directly measuring the loss rates in vacuum-sealed ampoules. Biotite shows 39 Ar losses between 0.1% and 16%. These losses are predominantly due to diffusion processes from K-poor alteration-phase intergrowths in the biotites at the elevated temperatures during the irradiation. Estimates for the irradiation temperatures range from 150 0 to 180 0 C. Direct 39 Ar recoil loss from biotite seems to be minor compared to difussion loss of recoil-implanted 39 Ar. Precise 40 Ar/ 39 Ar dating of biotites therefore requires the measurement of the 39 Ar losses during irradiation. Glauconite loses not only neutron-induced Ar isotopes ( 39 Ar: 20-22%, 37 Ar: 17-19%) but also radiogenic 40 Ar(∼9%). Slight 39 Ar losses are also observed for light micas (0.2% and 0.35%), hornblendes (0.1%) and sanidines (200 and 700 ppm). 25 refs.; 4 figs.; 6 tabs

  20. Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells.

    Science.gov (United States)

    Wang, Dan; Nguyen, Minh M; Masoodi, Khalid Z; Singh, Prabhpreet; Jing, Yifeng; O'Malley, Katherine; Dar, Javid A; Dhir, Rajiv; Wang, Zhou

    2015-12-01

    Androgen receptor (AR) plays a pivotal role in the development of primary as well as advanced castration-resistant prostate cancer. Previous work in our lab identified a novel nuclear export signal (NES) (NES(AR)) in AR ligand-binding domain essential for AR nucleocytoplasmic trafficking. By characterizing the localization of green fluorescence protein (GFP)-tagged NES(AR), we designed and executed a yeast mutagenesis screen and isolated 7 yeast mutants that failed to display the NES(AR) export function. One of those mutants was identified as the splicing factor pre-mRNA processing factor 8 (Prp8). We further showed that Prp8 could regulate NES(AR) function using short hairpin RNA knockdown of Prp8 coupled with a rapamycin export assay in mammalian cells and knockdown of Prp8 could induce nuclear accumulation of GFP-tagged AR in PC3 cells. Prp8 expression was decreased in castration-resistant LuCaP35 xenograft tumors as compared with androgen-sensitive xenografts. Laser capture microdissection and quantitative PCR showed Prp8 mRNA levels were decreased in human prostate cancer specimens with high Gleason scores. In prostate cancer cells, coimmunoprecipitation and deletion mutagenesis revealed a physical interaction between Prp8 and AR mainly mediated by NES(AR). Luciferase assay with prostate specific antigen promoter-driven reporter demonstrated that Prp8 regulated AR transcription activity in prostate cancer cells. Interestingly, Prp8 knockdown also increased polyubiquitination of endogenous AR. This may be 1 possible mechanism by which it modulates AR activity. These results show that Prp8 is a novel AR cofactor that interacts with NES(AR) and regulates AR function in prostate cancer cells.

  1. 40Ar-39Ar stepheating studies of clay concentrates from Irish orebodies

    International Nuclear Information System (INIS)

    Halliday, A.N.

    1978-01-01

    40 Ar- 39 Ar step heating analyses of clay concentrates from the Gortdrum and Tynagh orebodies (Ireland) previously dated by conventional K-Ar, indicate major losses of 39 Ar (32 to 45%) and rad. 40 Ar (25 to 35%) during the irradiation. The proportion of rad. 40 Ar loss, unlike that of 39 Ar, increases with J-value. The difference between 39 Ar and rad. 40 Ar proportion losses is related to the mineralogy and grain intimacy. These also affect the stepwise release patterns - the Gortdrum concentrates yield age spectra very consistent with 39 Ar recoil predictions, whereas the Tynagh concentrates in which the grains are intimately intergrown, show no clear evidence for 39 Ar recoil depletion in the K-rich phases. The difference is resolvable if illite argon release is not a simple volume diffusion type process under vacuum conditions. (author)

  2. HDR-Aggregate Read Service (ARS)

    Data.gov (United States)

    Department of Veterans Affairs — ARS is a SOAP web service exposed over HTTPS that provides an aggregated (report) view of HTH Survey, DMP and Census data stored in the HDR DB. ARS is deployed in...

  3. Study of the physical discharge properties of a Ar/O2 DC plasma jet

    Science.gov (United States)

    Barkhordari, A.; Ganjovi, A.; Mirzaei, I.; Falahat, A.

    2018-03-01

    In this paper, the physical properties of plasma discharge in a manufactured DC plasma jet operating with the Ar/O2 gaseous mixture are studied. Moreover, the optical emission spectroscopy technique is used to perform the experimental measurements. The obtained emission spectra are analyzed and, the plasma density, rotational, vibrational and electronic temperature are calculated. The NO emission lines from {NO }γ( A2 Σ^{+} \\to {X}2 Πr ) electronic transition are observed. It is seen that, at the higher argon contributions in Ar/O2 gaseous mixture, the emission intensities from argon ions will increase. Moreover, while the vibrational and excitation temperatures are increased at the higher input DC currents, they will decrease at the higher Ar percentages in the Ar/O2 gaseous mixture. Furthermore, at the higher DC currents and Ar contributions, both the plasma electron density and dissociation fraction of oxygen atoms are increased.

  4. $\\beta$ decay of $^{47}$Ar

    CERN Document Server

    Weissman, L; Bergmann, U C; Brown, B A; Catherall, R; Cederkäll, J; Dillmann, I; Hallmann, O; Fraile-Prieto, L M; Franchoo, S; Gaudefroy, L; Köster, U; Kratz, K L; Pfeiffer, B; Sorlin, O; 10.1103/PhysRevC.70.024304

    2004-01-01

    Information on beta -decay properties of neutron-rich /sup 47/Ar was obtained at the ISOLDE facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass separation. A doubly charged beam was used in order to improve the signal-to-background ratio associated with multi-charged noble gas fission products. The identification of the /sup 47/Ar gamma -ray transitions was performed by comparing the spectra obtained from direct proton bombardment of the target and of the neutron converter. New excited levels in the daughter /sup 47/K nucleus corresponding to the negative-parity states were observed. The obtained data are compared to the result of large-scale shell model calculations and quasiparticle random-phase approximation predictions. (29 refs).

  5. ARS - Helsinki - 2006 / Galina Balashova

    Index Scriptorium Estoniae

    Balashova, Galina

    2006-01-01

    Steven Holli projekteeritud Kiasma muuseumihoonest Helsingis. Kontseptuaalkunsti näitusest ARS 06 "Reaalsustunne" Kiasmas. Eestlastest esineb Mark Raidpere. Vene kunstnikegrupi AEC+F ja vene kunstnike Juri Vassiljevi ning Aleksandr Ponomarjovi töödest näitusel. Ka Gerda Steineri & Jörg Lenzlingeri (Šveits), Martin & Munoz'i (USA, Hispaania), arvutigraafik Charles Sandisoni (SB), videokunstnik Bill Viola (USA) jt. töödest

  6. Photoionization study of HgAr

    International Nuclear Information System (INIS)

    Linn, S.H.; Brom, J.M. Jr.; Tzeng, W.; Ng, C.Y.

    1985-01-01

    Photoionization efficiency data for HgAr + have been obtained in the region of 680--1240 A. The ionization energy of HgAr was determined to be 10.217 +- 0.012 eV. This value allows the calculation of the dissociation energy of HgAr + to be 0.228 +- 0.017 eV. The relative probabilities for the formation of HgAr + via the reactions Ar* x Hg or Hg* x Ar→ HgAr + +e - with Ar* and Hg* prepared in high Rydberg states in the energy range of 10.22--15.79 eV were estimated. Although the radii for the 3d and 5s Rydberg ortitals of Ar have similar values, the probabilities for the formation of HgAr + from Hg x Ar* with Ar* in the 5s[3/2] 0 1 and 5s'[1/2] 0 1 Rydberg states are substantially greater than those when the Ar* excited atoms are in the 3d[1/2] 0 1 , 3s[3/2] 0 1 , and 3d'[3/2] 0 1 Rydberg levels. The ratio for the cross sections for the formation of HgAr + from Hg x Ar* with Ar* formed in the 3d[1/2] 0 1 and 4d[1/2] 0 1 states, as well as that with Ar* prepared in the 5d[1/2] 0 1 and 6d[1/2] 0 1 states, were found to be consistent with the predictions of the previous impact parameter calculations

  7. Comparative simulation analysis on the ignition threshold of atmospheric He and Ar dielectric barrier discharge

    Science.gov (United States)

    Yao, Congwei; Chang, Zhengshi; Chen, Sile; Ma, Hengchi; Mu, Haibao; Zhang, Guan-Jun

    2017-09-01

    Dielectric barrier discharge (DBD) is widely applied in many fields, and the discharge characteristics of insert gas have been the research focus for years. In this paper, fluid models of atmospheric Ar and He DBDs driven by 22 kHz sinusoidal voltage are built to analyze their ignition processes. The contributions of different electron sources in ignition process are analyzed, including the direct ionization of ground state atom, stepwise ionization of metastable particles, and secondary electron emission from dielectric wall, and they play different roles in different discharge stages. The Townsend direct ionization coefficient of He is higher than Ar with the same electrical field intensity, which is the direct reason for the different ignition thresholds between He and Ar. Further, the electron energy loss per free electron produced in Ar and He DBDs is discussed. It is found that the total electron energy loss rate of Ar is higher than He when the same electrical field is applied. The excitation reaction of Ar consumes the major electron energy but cannot produce free electrons effectively, which is the essential reason for the higher ignition threshold of Ar. The computation results of He and Ar extinction voltages can be explained in the view of electron energy loss, as well as the experimental results of different extinction voltages between Ar/NH3 and He DBDs.

  8. AR, HEA and AAS in Rural Development Projects--Benchmarking towards the Best Processes.

    Science.gov (United States)

    Westermarck, Harri

    In most countries, agricultural research (AR), institutions of higher education in agriculture (HEA), and agricultural advisory services (AAS) function as separate agencies. So far, in most countries, AR, HEA, and AAS have not had a common vision for rural development. In Finland, domination of agricultural production in Finland has led to a lack…

  9. The SFMOMA AR Game Jam

    DEFF Research Database (Denmark)

    Brin, Sarah; Gangsei, Erica

    2018-01-01

    In the Summer of 2016, Pokémon Go precipitated a surge of new play experiences in museums. Cultural heritage institutions across disciplines were confronted with the sudden ubiquity of augmented reality (AR). Some museums enthusiastically integrated Pokémon into their programs, while some grapple......, and Rebecca Edwards. “Night at the Museum: The 2016 Getty/USC Game Jam.” Blog. The Getty Iris, March 31, 2016. http://blogs.getty.edu/iris/a-night-at-themuseum-the-2016-gettyusc-game-jam/....

  10. The effects of retrograde reactions and of diffusion on 39Ar-40Ar ages of micas

    DEFF Research Database (Denmark)

    Allaz, Julien; Engi, Martin; Berger, Alfons

    2011-01-01

    Effects of metamorphic reactions occurring during decompression were explored to understand their influence on 39Ar-40Ar ages of micas. Monometamorphic metasediments from the Lepontine Alps (Switzerland) were studied. Collected samples reached lower amphibolite facies during the Barrovian....... XRD-data indicated that some mineral separates prepared for Ar-Ar stepwise heating analysis were monomineralic, whereas others were composed of two white micas (muscovite with paragonite or margarite), or biotite and chlorite. In monomineralic samples 37Ar/39Ar and 38Ar/39Ar (proportional to Ca....../K and Cl/K ratios) did not change and the resulting ages can be interpreted unambiguously. In mineral separates containing two white micas, Ca/K and Cl/K ratios were variable, reflecting non-simultaneous laboratory degassing of the two heterochemical Ar-reservoirs. These ratios were used to identify each...

  11. 40Ar/39Ar dating of the Late Cretaceous

    International Nuclear Information System (INIS)

    Gaylor, Jonathan

    2013-01-01

    As part of the wider European GTS Next project, I propose new constraints on the ages of the Late Cretaceous, derived from a multitude of geochronological techniques, and successful stratigraphic interpretations from Canada and Japan. In the Western Canada Sedimentary Basin, we propose a new constraint on the age of the K/Pg boundary in the Red Deer River section (Alberta, Canada). We were able to cyclo-stratigraphically tune sediments in a non-marine, fluvial environment utilising high-resolution proxy records suggesting a 11-12 precession related cyclicity. Assuming the 40 Ar/ 39 Ar method is inter-calibrated with the cyclo-stratigraphy, the apparent age for C29r suggests that the K/Pg boundary falls between eccentricity maxima and minima, yielding an age of the C29r between 65.89 ± 0.08 and 66.30 ± 0.08 Ma. Assuming that the bundle containing the coal horizon represents a precession cycle, the K/Pg boundary is within the analytical uncertainty of the youngest zircon population achieving a revised age for the K/Pg boundary as 65.75 ± 0.06 Ma. The Campanian - Maastrichtian boundary is preserved in the sedimentary succession of the Horseshoe Canyon Formation and has been placed 8 m below Coal nr. 10. Cyclo-stratigraphic studies show that the formation of these depositional sequences (alternations) of all scales are influenced directly by sea-level changes due to precession but more dominated by eccentricity cycles proved in the cyclo-stratigraphic framework and is mainly controlled by sand horizons, which have been related by auto-cyclicity in a dynamic sedimentary setting. Our work shows that the Campanian - Maastrichtian boundary in the Western Canada Sedimentary Basin coincides with 2.5 eccentricity cycles above the youngest zircon age population at the bottom of the section and 4.9 Myr before the Cretaceous - Palaeogene boundary (K/Pg), and thus corresponds to an absolute age of 70.65 ± 0.09 Ma producing an 1.4 Myr younger age than recent published ages

  12. Triaxial superdeformation in 40Ar

    International Nuclear Information System (INIS)

    Taniguchi, Yasutaka; Ikeda, Kiyomi; Kanada-En'yo, Yoshiko; Kimura, Masaaki; Horiuchi, Hisashi; Ideguchi, Eiji

    2010-01-01

    Superdeformed (SD) states in 40 Ar have been studied using the deformed-basis antisymmetrized molecular dynamics. Low-energy states were calculated by the parity and angular momentum projection and the generator coordinate method (GCM). Basis wave functions were obtained by the energy variation with a constraint on the quadrupole deformation parameter β, while other quantities such as triaxiality γ were optimized by the energy variation. By the GCM calculation, an SD band was obtained just above the ground-state band. The SD band involves a K π =2 + side band due to the triaxiality. The calculated electric quadrupole transition strengths of the SD band reproduce the experimental values appropriately. Triaxiality is significant for understanding low-lying states.

  13. arXiv Probing Leptogenesis

    CERN Document Server

    Chun, E.J.; Dev, P.S.B.; Drewes, M.; Fong, C.S.; Garbrecht, B.; Hambye, T.; Harz, J.; Hernández, P.; Kim, C.S.; Molinaro, E.; Nardi, E.; Racker, J.; Rius, N.; Zamora-Saa, J.

    2018-02-28

    The focus of this chapter lies on the possible experimental tests of leptogenesis scenarios. We consider both leptogenesis generated from oscillations, as well as leptogenesis from out-of-equilibrium decays. As the Akhmedov-Rubakov-Smirnov (ARS) mechanism allows for heavy neutrinos in the GeV range, this opens up a plethora of possible experimental tests, e.g. at neutrino oscillation experiments, neutrinoless double beta decay, and direct searches for neutral heavy leptons at future facilities. In contrast, testing leptogenesis from out-of-equilibrium decays is a quite difficult task. We comment on the necessary conditions for having successful leptogenesis at the TeV-scale. We further discuss possible realizations and their model specific testability in extended seesaw models, models with extended gauge sectors, and supersymmetric leptogenesis. Not being able to test high-scale leptogenesis directly, we present a way to falsify such scenarios by focusing on their washout processes. This is discussed specific...

  14. Dating method with /sup 39/Ar

    Energy Technology Data Exchange (ETDEWEB)

    Loosli, H H [Bern Univ. (Switzerland). Physikalisches Inst.

    1983-04-01

    The principles of a dating method based on the cosmic-ray-produced radioisotope /sup 39/Ar are given. Technical requirements such as background and standard gas samples and gas proportional counting systems are described. With samples extracted from Greenland ice it can be demonstrated that /sup 39/Ar ages agree with ages obtained by other methods. First results on ocean water samples show that with this isotope valuable information on ocean mixing and circulation can be expected. /sup 39/Ar results on groundwater samples disagree for some aquifers with conventional /sup 14/C ages; possible explanations are discussed, especially underground production of /sup 39/Ar.

  15. GPS-Based AR Games Development Potential

    Directory of Open Access Journals (Sweden)

    Gregorius Alvin Raditya Santoso

    2014-11-01

    Full Text Available The application of new technologies in a game is not a new thing. One example is the application of Augmented Reality (AR technology in game. Many people do not know the application of AR technology in game, although the application of this technology is able to produce a game with unique gameplay. In addition, since AR game is GPS-based, it offers new gaming experience, that is, playing outdoors in which the real world becomes the game arena. This advantage gives the AR technology a huge potential to be developed into a game

  16. Electronic-state distribution of Ar* produced from Ar+(2P3/2)/2e- collisional radiative recombination in an argon flowing afterglow

    International Nuclear Information System (INIS)

    Tsuji, Masaharu; Matsuzaki, Toshinori; Tsuji, Takeshi

    2002-01-01

    The Ar + /2e - collisional radiative recombination has been studied by observing UV and visible emissions of Ar* in an Ar flowing afterglow. In order to clarify recombination mechanism, the Ar + ( 2 P 3/2 ) spin-orbit component was selected by using a filter gas of the Ar + ( 2 P 1/2 ) component. Spectral analysis indicated that 34 Ar*(4p, 4d, 5p, 5d, 6s, 6p, 6d, 4p ' , 4d ' , 5p ' , 5d ' , 6s ' ) states in the 13.08-15.33 eV range are produced. The electronic-state distribution decreased with an increase in the excitation energy of Ar*, which was expressed by a Boltzmann electronic temperature of 0.54 eV. The formation ratios of the 4p: 4d + 5p + 5d + 6s + 6p + 6d: 4p ' : 4d ' + 5p ' + 5d ' + 6s ' states were 43%, 2.8%, 54%, and 0.31%, respectively. The high formation ratio of the 4p ' state having an Ar + ( 2 P 1/2 ) ion core in the Ar + ( 2 P 3/2 )/2e - recombination indicated that such a two-electron process as an electron transfer to an inner 3p orbital followed by excitation of a 3p electron to an outer 4p orbital occurs significantly. The higher formation ratios of 4d + 5p + 5d + 6s + 6p + 6d than those of 4d ' + 5p ' + 5d ' + 6s ' led us to conclude the formation of these upper states dominantly proceeds through one electron transfer to an outer nl orbital of Ar + ( 2 P 3/2 )

  17. 39Ar/Ar measurements using ultra-low background proportional counters

    International Nuclear Information System (INIS)

    Hall, Jeter; Aalseth, Craig E.; Bonicalzi, Ricco M.; Brandenberger, Jill M.; Day, Anthony R.; Humble, Paul H.; Mace, Emily K.; Panisko, Mark E.; Seifert, Allen

    2016-01-01

    Age-dating groundwater and seawater using the 39 Ar/Ar ratio is an important tool to understand water mass-flow rates and mean residence time. Low-background proportional counters developed at Pacific Northwest National Laboratory use mixtures of argon and methane as counting gas. We demonstrate sensitivity to 39 Ar by comparing geological (ancient) argon recovered from a carbon dioxide gas well and commercial argon. The demonstrated sensitivity to the 39 Ar/Ar ratio is sufficient to date water masses as old as 1000 years. - Highlights: • 39 Ar/Ar age dating is important for understanding environmental water migration. • Ultra low background proportional counters have been developed. • 39 Ar is detected in atmospheric argon at a rate of 70.3 counts per day. The demonstrated background is 166 counts per day. • Age dating is possible for water with underground residence time of up to 1000 years.

  18. 40Ar-39Ar method for age estimation: principles, technique and application in orogenic regions

    International Nuclear Information System (INIS)

    Dalmejer, R.

    1984-01-01

    A variety of the K-Ar method for age estimation by 40 Ar/ 39 Ar recently developed is described. This method doesn't require direct analysis of potassium, its content is calculated as a function of 39 Ar, which is formed from 39 K under neutron activation. Errors resulted from interactions between potassium and calcium nuclei with neutrons are considered. The attention is paid to the technique of gradual heating, used in 40 Ar- 39 Ar method, and of obtaining age spectrum. Aplicabilities of isochronous diagram is discussed for the case of presence of excessive argon in a sample. Examples of 40 Ar- 39 Ar method application for dating events in orogenic regions are presented

  19. Experimental Determination of the Cosmogenic Ar Production Rate From Ca

    Science.gov (United States)

    Niedermann, S.; Schäfer, J. M.; Wieler, R.; Naumann, R.

    2005-12-01

    Cosmogenic 38Ar is produced in terrestrial surface rocks by spallation of target nuclides, in particular K and Ca. Though the presence of cosmogenic Ar in Ca-rich minerals has been demonstrated earlier [1], is has proven difficult to establish its production rate. To circumvent problems connected to 36Ar production by 35Cl neutron capture and different production rates from K and Ca, we have analyzed the noble gases in seven pyroxene separates (px) from the Antarctic Dry Valleys which are essentially free of Cl and K. The px were obtained from dolerite rocks, for which 3He and 21Ne exposure ages from 1.5 to 6.5 Ma have been reported [2]. The noble gases were extracted in two or three heating steps at GFZ Potsdam, yielding 38Ar/36Ar ratios up to 0.2283 ± 0.0008 (air: 0.1880). Ca (3.7-11.2 wt. %) is expected to be the only relevant target element for Ar production in the five pure px (ratio of 1.5 ± 0.2, we obtain cosmogenic 38Ar concentrations between 130 and 530x106 atoms/g. The 38Ar production rate was calculated based on 21Ne exposure ages [2], corrected for elevated nuclide production in Antarctica due to prevailing low air pressure and for the revised 21Ne production rate from Si. We obtain values between 188 ± 17 and 243 +110/-24 atoms (g Ca)-1 a-1 at sea level and high (northern) latitudes for four out of the five pure px, while one yields a very high value of 348 ± 70 atoms (g Ca)-1 a-1. Values above 250 atoms (g Ca)-1 a-1 are also obtained from two less pure px containing 0.3 and 0.9% K and from one feldspar/quartz accumulate, indicating that the production rate from K may be higher than that from Ca. The weighted mean (excluding the outlier) of ~200 atoms (g Ca)-1 a-1 is in excellent agreement with Lal's [3] theoretical estimate. [1] Renne et al., EPSL 188 (2001) 435. [2] Schäfer et al., EPSL 167 (1999) 215. [3] Lal, EPSL 104 (1991) 424.

  20. First-principles calibration of 40Ar/39Ar mineral standards and complete extraction of 40Ar* from sanidine

    Science.gov (United States)

    Morgan, L. E.; Kuiper, K.; Mark, D.; Postma, O.; Villa, I. M.; Wijbrans, J. R.

    2010-12-01

    40Ar/39Ar geochronology relies on comparing argon isotopic data for unknowns to those for knowns. Mineral standards used as neutron fluence monitors must be dated by the K-Ar method (or at least referenced to a mineral of known K-Ar age). The commonly used age of 28.02 ± 0.28 Ma for the Fish Canyon sanidine (FCs) (Renne et al., 1998) is based upon measurements of radiogenic 40Ar in GA1550 biotite (McDougall and Roksandic, 1974), but underlying full data were not published (these measurements were never intended for use as an international standard), so uncertainties are difficult to assess. Recent developments by Kuiper et al. (2008) and Renne et al. (2010) are limited by their reliance on the accuracy of other systems. Modern technology should allow for more precise and accurate calibration of primary K-Ar and 40Ar/39Ar standards. From the ideal gas law, the number of moles of 40Ar in a system can be calculated from measurements of pressure, volume, and temperature. Thus we have designed and are proceeding to build a pipette system to introduce well-determined amounts of 40Ar into noble gas extraction lines and mass spectrometers. This system relies on components with calibrations traceable to SI unit prototypes, including a diaphragm pressure gauge (MKS Instruments), thermocouples, and a “slug” of an accurately determined volume to be inserted into the reservoir for volume determinations of the reservoir and pipette. The system will be renewable, with a lifetime of ca. 1 month for gas in the reservoir, and portable, to permit interlaboratory calibrations. The quantitative extraction of 40Ar* from the mineral standard is of highest importance; for sanidine standards this is complicated by high melt viscosity during heating. Experiments adding basaltic “zero age glass” (ZAG) to decrease melt viscosity are underway. This has previously been explored by McDowell (1983) with a resistance furnace, but has not been quantitatively addressed with laser heating

  1. Allegheny County Walk Scores

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Walk Score measures the walkability of any address using a patented system developed by the Walk Score company. For each 2010 Census Tract centroid, Walk Score...

  2. 244-AR Vault Interim Stabilization Project Plan

    International Nuclear Information System (INIS)

    LANEY, T.

    2000-01-01

    The 244-AR Vault Facility, constructed between 1966 and 1968, was designed to provide lag storage and treatment for the Plutonium-Uranium Extraction Facility (PUREX) tank farm sludges. Tank farm personnel transferred the waste from the 244-AR Vault Facility to B Plant for recovery of cesium and strontium. B Plant personnel then transferred the treatment residuals back to the tank farms for storage of the sludge and liquids. The last process operations, which transferred waste supporting the cesium/strontium recovery mission, occurred in April 1978. After the final transfer in 1978, the 244-AR facility underwent a cleanout. However, 2,271 L (600 gal) of sludge were left in Tank 004AR from an earlier transfer from Tank 241-AX-104. When the cleanout was completed, the facility was placed in a standby status. The sludge had been transferred to Tank 004AR to support Pacific Northwest National Laboratory [PNNL] vitrification work. Documentation of waste transfers suggests that a portion of the sludge may have been moved from Tank 004AR to Tank 002AR in preparation for transfer back to the AX Tank Farm; however, quantities of the sludge that were moved to Tank 002AR from that transfer must be estimated

  3. Backbendings of superdeformed bands in 36;40Ar

    Science.gov (United States)

    Xiang, Xu-Hui; He, Xiao-Tao

    2018-05-01

    Experimentally observed superdeformed (SD) rotational bands in 36Ar and 40Ar are studied by the cranked shell model (CSM) with the pairing correlations treated by a particle-number-conserving (PNC) method. This is the first time that PNC-CSM calculations have been performed on the light nuclear mass region around A=40. The experimental kinematic moments of inertia J (1) versus rotational frequency are reproduced well. The backbending of the SD band at frequency around ℏω=1.5 MeV in 36Ar is attributed to the sharp rise of the simultaneous alignments of the neutron and proton 1d 5/2[202]5/2 pairs and 1f 7/2[321]3/2 pairs, which is a consequence of the band crossing between the 1d 5/2[202]5/2 and 1f 7/2[321]3/2 configuration states. The gentle upbending at low frequency of the SD band in 40Ar is mainly affected by the alignments of the neutron 1f 7/2[321]3/2 pairs and proton 1d 5/2[202]5/2 pairs. The PNC-CSM calculations show that besides the diagonal parts, the off-diagonal parts of the alignments play an important role in the rotational behavior of the SD bands. Supported by National Natural Science Foundation of China (11775112 and 11275098) and the Priority Academic Program Development of Jiangsu Higher Education Institutions

  4. Bacillus sp.CDB3 isolated from cattle dip-sites possesses two ars gene clusters

    Institute of Scientific and Technical Information of China (English)

    Somanath Bhat; Xi Luo; Zhiqiang Xu; Lixia Liu; Ren Zhang

    2011-01-01

    Contamination of soil and water by arsenic is a global problem.In Australia, the dipping of cattle in arsenic-containing solution to control cattle ticks in last centenary has left many sites heavily contaminated with arsenic and other toxicants.We had previously isolated five soil bacterial strains (CDB1-5) highly resistant to arsenic.To understand the resistance mechanism, molecular studies have been carried out.Two chromosome-encoded arsenic resistance (ars) gene clusters have been cloned from CDB3 (Bacillus sp.).They both function in Escherichia coli and cluster 1 exerts a much higher resistance to the toxic metalloid.Cluster 2 is smaller possessing four open reading frames (ORFs) arsRorf2BC, similar to that identified in Bacillus subtilis Skin element.Among the eight ORFs in cluster 1 five are analogs of common ars genes found in other bacteria, however, organized in a unique order arsRBCDA instead of arsRDABC.Three other putative genes are located directly downstream and designated as arsTIP based on the homologies of their theoretical translation sequences respectively to thioredoxin reductases, iron-sulphur cluster proteins and protein phosphatases.The latter two are novel of any known ars operons.The arsD gene from Bacillus species was cloned for the first time and the predict protein differs from the well studied E.coli ArsD by lacking two pairs of C-terrninal cysteine residues.Its functional involvement in arsenic resistance has been confirmed by a deletion experiment.There exists also an inverted repeat in the intergenic region between arsC and arsD implying some unknown transcription regulation.

  5. The role of the AR/ER ratio in ER-positive breast cancer patients.

    Science.gov (United States)

    Rangel, Nelson; Rondon-Lagos, Milena; Annaratone, Laura; Osella-Abate, Simona; Metovic, Jasna; Mano, Maria Piera; Bertero, Luca; Cassoni, Paola; Sapino, Anna; Castellano, Isabella

    2018-03-01

    The significance of androgen receptor (AR) in breast cancer (BC) management is not fully defined, and it is still ambiguous how the level of AR expression influences oestrogen receptor-positive (ER+) tumours. The aim of the present study was to analyse the prognostic impact of AR/ER ratio, evaluated by immunohistochemistry (IHC), correlating this value with clinical, pathological and molecular characteristics. We retrospectively selected a cohort of 402 ER+BC patients. On each tumour, IHC analyses for AR, ER, PgR, HER2 and Ki67 were performed and AR+ cases were used to calculate the AR/ER value. A cut-off of ≥2 was selected using receiver-operating characteristic (ROC) curve analyses. RNA from 19 cases with AR/ER≥2 was extracted and used for Prosigna-PAM50 assays. Tumours with AR/ER≥2 (6%) showed more frequent metastatic lymph nodes, larger size, higher histological grade and lower PgR levels than cases with AR/ERAR/ER≥2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P  ≤ 0.004). According to the Prosigna-PAM50 assay, 63% (12/19) of these cases resulted in intermediate or high risk of recurrence categories. Additionally, although all samples were positive for ER assessed by IHC, the molecular test assigned 47.4% (9/19) of BCs to intrinsic non-luminal subtypes. In conclusion, the AR/ER ratio ≥2 identifies a subgroup of patients with aggressive biological features and may represent an additional independent marker of worse BC prognosis. Moreover, the Prosigna-PAM50 results indicate that a significant number of cases with AR/ER≥2 could be non-luminal tumours. © 2018 Society for Endocrinology.

  6. AR4VI: AR as an Accessibility Tool for People with Visual Impairments

    OpenAIRE

    Coughlan, James M.; Miele, Joshua

    2017-01-01

    Although AR technology has been largely dominated by visual media, a number of AR tools using both visual and auditory feedback have been developed specifically to assist people with low vision or blindness – an application domain that we term Augmented Reality for Visual Impairment (AR4VI). We describe two AR4VI tools developed at Smith-Kettlewell, as well as a number of pre-existing examples. We emphasize that AR4VI is a powerful tool with the potential to remove or significantly reduce a r...

  7. 40Ar/39Ar age spectra from the KBS Tuff, Koobi Fora Formation

    International Nuclear Information System (INIS)

    McDougall, I.

    1981-01-01

    40 Ar/ 39 Ar age spectra on anorthoclase phenocrysts from three pumice clasts in the KBS Tuff yield nearly ideal flat patterns, providing good evidence that the samples have remained undisturbed since crystallization. The ages are concordant at 1.88 = 0.02 Myr, and confirm that the KBS Tuff, a key marker bed in the Koobi Fora Formation, northern Kenya, is now very well dated. These results resolve the conflict between earlier 40 Ar/ 39 Ar and conventional K-Ar dating measurements on the KBS Tuff. (author)

  8. 40Ar/39Ar age spectra from the KBS Tuff, Koobi Fora Formation.

    Science.gov (United States)

    McDougall, Ian

    1981-11-12

    40 Ar/ 39 Ar age spectra on anorthoclase phenocrysts from three pumice clasts in the KBS Tuff yield nearly ideal flat patterns, providing good evidence that the samples have remained undisturbed since crystallization. The ages are concordant at 1.88±0.02 Myr, and confirm that the KBS Tuff, a key marker bed in the Koobi Fora Formation, northern Kenya, is now very well dated. These results resolve the conflict between earlier 40 Ar/ 39 Ar and conventional K-Ar dating measurements on the KBS Tuff.

  9. Effects of shock pressure on 40Ar-39Ar radiometric age determinations

    International Nuclear Information System (INIS)

    Davis, P.K.

    1977-01-01

    The relation of shock to the drop in the 40 *Ar/ 39 *Ar ratio seen at high release temperatures in some neutron-irradiated lunar samples is investigated through measurements of the 40 *Ar/ 39 *Ar ratio in gas samples released by stepwise heating of rock samples previously subjected to shock, either in the laboratory or in nature. Explosives were used to shock solid pieces and powder of a basalt from a diabase dike in Liberia to calculated pressures of 65, 150 and 270 kbar. These, an unshocked sample of the powder, two naturally shocked samples from the Brent impact crater in Canada, one unshocked sample from near the crater, and appropriate monitors were irradiated. Ar from stepwise heating was analyzed. The unshocked basalt shows a good 40 *Ar/ 39 *Ar plateau at age 198 +-9 m.y. in agreement with a previous result of 186 +- 2 m.y. The shocked samples contain varying amounts of implanted atmospheric Ar, the isotopes of which have experienced mass fractionation. This effect is small enough in four samples so that the linearity of their graphs of 39 *Ar/ 40 Ar vs 36 Ar/ 40 Ar is evidence of a plateau. The ages of these samples are then 201 +- 10, 205 +- 12 and 201 +-9 m.y. It appears that the shock has had little effect on the 40 Ar- 39 Ar age spectrum, although the release patterns of the 39 *Ar are shifted downward by the order of 200 0 C. Shock implantation of Ar was at lower shock pressure, in the presence of less Ar, and into a less porous material than previously demonstrated. The Brent Crater samples do not all show good plateaus, but do indicate an age of 420 m.y. for the crater event and 795 +- 24 m.y. for the rock formation, in agreement with previous results. None of the 40 *Ar/ 39 *Ar profiles shows a drop at high temperature, but a possible role of shock implantation of Ar is indicated in the production of this effect. Further experiments are suggested. (author)

  10. Photodissociation dynamics of Ar2(+) and Ar3(+) excited by 527 nm photons.

    Science.gov (United States)

    Lepère, V; Picard, Y J; Barat, M; Fayeton, J A; Lucas, B; Béroff, K

    2009-05-21

    The photofragmentation dynamics of Ar(2)(+) and Ar(3)(+) clusters has been investigated at a 527 nm wavelength (2.35 eV) using a setup that allows simultaneous detection of the ionic and neutral fragments in a coincidence experiment. Measurement of positions and times of flight enables in principle a complete description of the fragmentation dynamics. The photofragmentation dynamics of Ar(3)(+) clusters is similar to that of Ar(2)(+) with, in addition, the ejection of a third fragment that can be neutral or ionized via a resonant electron capture. This is attributed to the triangular geometry of the Ar(3)(+) ion.

  11. Single electron capture by state-prepared Ar2+ projectiles in Ar

    International Nuclear Information System (INIS)

    Puerta, J.; Huber, B.A.

    1985-03-01

    Electron capture by state-selected Ar 2+ projectiles in Ar has been studied at low collision energies ( 2+ ions are measured explaining existing discrepancies of partial and total cross sections in the Ar 2+ /Ar collision system. Although highly excited metastable ions ( 5 D 4 0 , 3 F 4 0 ) represent a minor contamination of a non-prepared Ar 2+ beam (proportional1%), their contributions are found to dominate the capture process due to cross section values larger than 10 -15 cm 2 . (orig.)

  12. 3 to 15 keV Ar+ induced Auger electron emission from Si and Ar

    International Nuclear Information System (INIS)

    Kempf, J.; Kaus, G.

    1977-01-01

    Ar + induced Auger electrons from Si and Ar were investigated at bombardment energies between 3-15 keV and target currents of a few μA. The Auger electron yields were compared with secondary ion yields of Si and Ar by simultaneous SIMS-AES measurements. In the ion induced Auger spectra of Si five Auger peaks and in the Ar spectra three Auger peaks were observed. The ion induced Auger electron yield of Si and Ar were found to be strongly dependent upon the primary ion energy. 'Bulk like' and 'atomic like' Auger transitions of ion induced Auger electrons of Si were observed. (orig.) [de

  13. A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model-application to low LET and high LET AR and BE data.

    Science.gov (United States)

    Leonard, Bobby E

    2008-08-01

    It has been suggested that Adaptive Response (AR) may reduce risk of adverse health effects due to ionizing radiation. But very low dose Bystander Effects (BE) may impose dominant deleterious human risks. These conflicting behaviors have stimulated controversy regarding the Linear No-Threshold human risk model. A dose and dose rate-dependent microdose model, to examine AR behavior, was developed in prior work. In the prior work a number of in vitro and in vivo dose response data were examined with the model. Recent new data show AR behavior with some evidence of very low dose BE. The purpose of this work is to supplement the microdose model to encompass the Brenner and colleagues BaD (Bystander and Direct Damage) model and apply this composite model to obtain new knowledge regarding AR and BE and illustrate the use of the model to plan radio-biology experiments. The biophysical composite AR and BE Microdose Model quantifies the accumulation of hits (Poisson distributed, microdose specific energy depositions) to cell nucleus volumes. This new composite AR and BE model provides predictions of dose response at very low dose BE levels, higher dose AR levels and even higher dose Direct (linear-quadratic) Damage radiation levels. We find good fits of the model to both BE data from the Columbia University microbeam facility and combined AR and BE data for low Linear Energy Transfer (LET) and high LET data. A Bystander Factor of about 27,000 and an AR protection factor of 0.61 are obtained for the low LET in vivo mouse spleen exposures. A Bystander Factor of 317 and an AR protection factor of 0.53 are obtained for high LET radon alpha particles in human lymphocytes. In both cases the AR is activated at most by one or two radiation induced charged particle traversals through the cell nucleus. The results of the model analysis is consistent with a premise that both Bystander damage and Adaptive Response radioprotection can occur in the same cell type, derived from the same

  14. 37Ar and 39Ar in meteorites and the spatial cosmic ray gradient

    International Nuclear Information System (INIS)

    Heusser, G.; Schaeffer, O.A.

    1977-01-01

    Cosmic-ray-produced 37 Ar (tsub(1/2) = 35 days), and 39 Ar (tsub(1/2) = 269 years) in the Fe-Ni phase of meteorites have been studied in connection with their implications for the radial gradient of cosmic ray particles. For the chondrite, Canon City, which fell on October 27, 1973, 20.1 +- 1.5 dpm/kg FeNi of 37 Ar and 22.5 +- 1.4 dpm/kg FeNi of 39 Ar was found. Usually, the 37 Ar/ 39 Ar ratio is used to deduce a spatial gradient. However, 37 Ar data reported in the literature are inconsistent. They fluctuate much more than could be accounted for by different orbits and the anticipated correlation with the cosmic ray neutron registrations is rather weak. Consequently, the 37 Ar/ 39 Ar-derived gradient has a low confidence level. On the other hand, 39 Ar activities group close to a mean value of 22.5 dpm/kg FeNi and appear to be almost independent of the different meteoroid orbits. A comparison of measured 39 Ar activities in meteorites with those calculated for orbits obtained from fireball data shows that a gradient of 10%/Au or less is reconcilable with the experimental findings. The average gradient (E > 200 MeV) during the last 500 years was probably not much larger than that measured presently by the Pioneer 10 and 11, and Helios spacecrafts. (Auth.)

  15. 40Ar/39Ar laser-probe dating of diamond inclusions from the Premier kimberlite

    International Nuclear Information System (INIS)

    Phillips, D.; Onstott, T.C.; Harris, J.W.; Strathclyde Univ., Glasgow

    1989-01-01

    Inclusions encapsulated by diamonds at the time of their formation provide a means for determining diamond crystallization ages and the chemistry of the surrounding upper mantle at that time. Sm-Nd studies of peridotitic inclusions, from Cretaceous-age kimberlites in southern Africa, suggest that the diamonds formed 3.3 Gyr ago. By contrast, eclogite-suite inclusions generally yield younger ages, sometimes approaching the time of kimberlite eruption. Here we report the results of 40 Ar/ 39 Ar laser-probe analyses of individual eclogitic clinopyroxene inclusions from Premier diamonds, which yield a mean age of 1,198±14 Myr. This age agrees well with Sm-Nd and 40 Ar/ 39 Ar analyses on similar Premier inclusions, and is indistinguishable from the inferred time of emplacement of the host kimberlite (1,150-1,230 Myr), which implies that diamond formation was essentially synchronous with kimberlite generation. The extrapolated non-radiogenic 40 Ar/ 36 Ar ratio of 334±102 is similar to the present-day atmospheric composition. This value is inconsistent with Sr and Nd isotopic signatures from Premier eclogite inclusions, which suggest a depleted mantle source ( 40 Ar/ 36 Ar>20,000). Pre-entrapment equilibration of the inclusions with an 36 Ar-rich fluid is the most probable explanation for the low non-radiogenic ( 40 Ar/ 36 Ar) composition. (author)

  16. Evidence of interatomic Coulombic decay in ArKr after Ar 2p Auger decay

    International Nuclear Information System (INIS)

    Morishita, Y; Saito, N; Suzuki, I H; Fukuzawa, H; Liu, X-J; Sakai, K; Pruemper, G; Ueda, K; Iwayama, H; Nagaya, K; Yao, M; Kreidi, K; Schoeffler, M; Jahnke, T; Schoessler, S; Doerner, R; Weber, T; Harries, J; Tamenori, Y

    2008-01-01

    We have identified interatomic Coulombic decay (ICD) processes in the ArKr dimer following Ar 2p Auger decay, using momentum-resolved electron-ion-ion coincidence spectroscopy and simultaneously determining the kinetic energy of the ICD electron and the KER between Ar 2+ and Kr + . We find that the spin-conserved ICD processes in which Ar 2+ (3p -3 3d) 1 P and 3 P decay to Ar 2+ (3p -2 ) 1 D and 3 P, respectively, ionizing the Kr atom, are significantly stronger than the spin-flip ICD processes in which Ar 2+ (3p -3 3d) 1 P and 3 P decay to Ar 2+ (3p -2 ) 3 P and 1 D, respectively

  17. On mechanism of Ar(3p54p) states excitation in low-energy Ar-Ar collisions

    International Nuclear Information System (INIS)

    Kurskov, S Y; Kashuba, A S

    2009-01-01

    The present work is devoted to study of Ar(3p 5 4p) states excitation in binary low-energy Ar-Ar collisions. The results of the experimental investigation of excitation cross sections of Ar I 4p'[l/2] 1 , 4p'[3/2] 1 , 4p'[3/2] 2 and 4p[3/2] 2 levels in the collision energy range from threshold up to 500 eV (cm) and degree of polarization for 4s[3/2] 2 0 -4p'[l/2] 1 and 4s[3/2] 2 0 -4p[3/2] 2 transitions in this energy range are represented.

  18. Ars Baltica-verkoston puheenjohtajuus Suomeen Risto Ruohoselle

    Index Scriptorium Estoniae

    1999-01-01

    1990. a. loodud võrgustiku Ars Baltica sekretariaat (Ars Baltica Contact Point & Communication Center) tuleb Kielist Tallinnasse Eesti kultuuriministeeriumi kuni aastani 2002 (Suur-Karja 23). Ars Baltica (ühendus)

  19. A flavor of 40Ar-39Ar geochronology research at lIT Bombay

    International Nuclear Information System (INIS)

    Pande, Kanchan

    2017-01-01

    Geochronology based on radiogenic isotopes has become an invaluable tool in earth sciences. Several radioactive parent-daughter systems of varying half-lives such as Rb-Sr, Sm-Nd, K-Ar have been traditionally used by researchers for determining the timing of geological and planetary processes. 40 Ar- 39 Ar dating, a variant of the K-Ar system, is a well-established and versatile method of determining the eruptive ages of volcanic rocks and the ∼150-500° C thermal histories of a variety of more slowly cooled igneous and metamorphic rocks. In the 40 Ar- 39 Ar method the sample is irradiated by fast neutrons in a nuclear reactor to convert some of 39 K into 39 Ar. The fixed natural ratio 39 K/ 40 K provides estimate for the parent 40 K by measuring 39 Ar. In order to know the conversion factor of 39 K to 39 Ar and to take care of other nuclear interfering reactions a sample of known K-Ar age is irradiated along with the unknown. The age of the unknown is then derived by comparison with the monitor sample of known age

  20. Ar-40/Ar-39 Studies of Martian Meteorite RBT 04262 and Terrestrial Standards

    Science.gov (United States)

    Park, J.; Herzog, G. F.; Turrin, B.; Lindsay, F. N.; Delaney, J. S.; Swisher, C. C., III; Nagao, K.; Nyquist, L. E.

    2014-01-01

    Park et al. recently presented an Ar-40/Ar-39 dating study of maskelynite separated from the Martian meteorite RBT 04262. Here we report an additional study of Ar-40/Ar-39 patterns for smaller samples, each consisting of only a few maskelynite grains. Considered as a material for Ar-40/Ar-39 dating, the shock-produced glass maskelynite has both an important strength (relatively high K concentration compared to other mineral phases) and some potentially problematic weaknesses. At Rutgers, we have been analyzing small grains consisting of a single phase to explore local effects that might be averaged and remain hidden in larger samples. Thus, to assess the homogeneity of the RBT maskelynite and for comparison with the results of, we analyzed six approx. 30 microgram samples of the same maskelynite separate they studied. Furthermore, because most Ar-40/Ar-39 are calculated relative to the age of a standard, we present new Ar-40/Ar-39 age data for six standards. Among the most widely used standards are sanidine from Fish Canyon (FCs) and various hornblendes (hb3gr, MMhb-1, NL- 25), which are taken as primary standards because their ages have been determined by independent, direct measurements of K and A-40.

  1. Evolution of the Ar isotopic chain: the N=28 shell gap south of {sup 48}Ca

    Energy Technology Data Exchange (ETDEWEB)

    Mengoni, D., E-mail: Daniele.Mengoni@uws.ac.u [Dipartimento di Fisica dell' Universita and INFN Sezione di Padova, Padova (Italy); Valiente-Dobon, J.J. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Gadea, A. [Instituto de Fisica Corpuscular, CSIC-Universidad de Valencia (Spain); Lenzi, S.M.; Lunardi, S. [Dipartimento di Fisica dell' Universita and INFN Sezione di Padova, Padova (Italy); Broda, R. [Institute of Nuclear Physics, Polish Academy of Sciences, Cracow (Poland); Dewald, A.; Pissulla, T. [Institut fuer Kernphysik der Universtaet zu Koeln, Koeln (Germany); Angus, L. [School of Engineering and Science, University of Paisley, Paisley, Scotland (United Kingdom); Aydin, S.; Bazzacco, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Padova (Italy); Benzoni, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Milano (Italy); Bizzeti, P.G.; Bizzeti-Sona, A.M. [Dipartimento di Fisica dell' Universita and INFN Sezione di Firenze, Firenze (Italy); Corradi, L. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Crespi, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Milano (Italy); Angelis, G. de [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Farnea, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Padova (Italy); Fioretto, E. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Goergen, A. [CEA Saclay, Daphnia/SphN, Gif-sur-Yvette Cedex (France)

    2010-03-01

    The lifetimes of the first excited states of the Z = 18 {sup 44}Ar and {sup 46}Ar isotopes have been determined using a novel technique that combines the Recoil Distance Doppler Shift method with the CLARA-PRISMA spectrometers for Multinucleon Transfer Reactions. The B(E2) values extracted for the 2{sup +}->0{sup +} transitions in both nuclei, as well as for higher excites states in {sup 44}Ar, are discussed and compared with the available experimental results and with the new large-scale shell-model calculations.

  2. FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer

    International Nuclear Information System (INIS)

    Qiu, Meiting; Bao, Wei; Wang, Jingyun; Yang, Tingting; He, Xiaoying; Liao, Yun; Wan, Xiaoping

    2014-01-01

    Increasing evidence suggests that forkhead box A1 (FOXA1) is frequently dysregulated in many types of human cancers. However, the exact function and mechanism of FOXA1 in human endometrial cancer (EC) remains unclear. FOXA1 expression, androgen receptor (AR) expression, and the relationships of these two markers with clinicopathological factors were determined by immunohistochemistry analysis. FOXA1 and AR were up-regulated by transient transfection with plasmids, and were down-regulated by transfection with siRNA or short hairpin RNA (shRNA). The effects of FOXA1 depletion and FOXA1 overexpression on AR-mediated transcription as well as Notch pathway and their impact on EC cell proliferation were examined by qRT-PCR, western blotting, co-immunoprecipitation, ChIP-PCR, MTT, colony-formation, and xenograft tumor–formation assays. We found that the expression of FOXA1 and AR in ECs was significantly higher than that in a typical hyperplasia and normal tissues. FOXA1 expression was significantly correlated with AR expression in clinical tissues. High FOXA1 levels positively correlated with pathological grade and depth of myometrial invasion in EC. High AR levels also positively correlated with pathological grade in EC. Moreover, the expression of XBP1, MYC, ZBTB16, and UHRF1, which are downstream targets of AR, was promoted by FOXA1 up-regulation or inhibited by FOXA1 down-regulation. Co-immunoprecipitation showed that FOXA1 interacted with AR in EC cells. ChIP-PCR assays showed that FOXA1 and AR could directly bind to the promoter and enhancer regions upstream of MYC. Mechanistic investigation revealed that over-expression of Notch1 and Hes1 proteins by FOXA1 could be reversed by AR depletion. In addition, we showed that down-regulation of AR attenuated FOXA1-up-regulated cell proliferation. However, AR didn’t influence the promotion effect of FOXA1 on cell migration and invasion. In vivo xenograft model, FOXA1 knockdown reduced the rate of tumor growth. These

  3. Ars ornata / Kadri Mälk

    Index Scriptorium Estoniae

    Mälk, Kadri, 1958-

    1998-01-01

    V rahvusvaheline ehtekunsti konverents 'Ars ornata Europeana' juuni lõpus Stockholmis. New Yorgis elava kuraatori Charon Kranseni ja prantsuse ehtekunstniku Christophe Burger' juhitud vestlusringidest. 1997. a. Pariisis loodud International Craft Design Association'ist (ICDA).

  4. ARS 01 Helsingi Kiasmas / Tarmo Virki

    Index Scriptorium Estoniae

    Virki, Tarmo

    2001-01-01

    Helsingis Kiasmas avatud rahvusvahelisest kunstinäitusest ARS 01 alapealkirjaga "Avanevaid perspektiive", kus esines oma töödega ka Marko Mäetamm. Näituse raames toimuvast Santiago Sierra kunstiprojektist kodututega

  5. Vector analyzing power and cross section for the reactions 40Ar(d(pol),p)41Ar and 40Ar(d(pol),t)39Ar

    International Nuclear Information System (INIS)

    Sen, S.; Darden, S.E.; Yoh, W.A.; Berners, E.D.

    1975-01-01

    Angular distributions of vector analyzing power and cross section for the reactions 40 Ar(d,p) 41 Ar and 40 Ar(d,t) 39 Ar have been measured at an incident deuteron energy of 14.83 MeV. The bound-state data in the (d,p) reaction and the (d,t) data are compared to DWBA calculations. The data for the neutron-unbound states are analyzed in the framework of the DWBA using (i) a form factor for weakly bound neutron and (ii) a resonance form factor, following the approach of Vincent and Fortune. The j-dependence of the (d,p) vector analyzing power permits definite spin-parity assignments to be made for 19 neutron-bound and 4 neutron unbound states in 41 Ar with excitation energy up to 6.57 MeV. Tentative Jsup(π) assignments have been made for 3 states. The l-value for the 5.62 MeV states has been determined. Data for the observed unbound states are found to be equally well reproduced by the type (i) calculations as by the type (ii) calculations. The (d,t) vector cnalyzing power data show definite J-dependence although not as strongly as in the (d,p) reaction. For relatively weakly excited states a pre-knowledge of the l-value of the transition is desirable for an unambiguous spin assignment. In general, the J-dependence in the (d,t) vector analyzing power can be utilized for definitive Jsup(π) assignments. On this basis, Jsub(π) values have been assigned for seven states in 39 Ar with excitation energies up to 4.47MeV excitation. Possible spin values for three other states are suggested. Spectroscopic factors fo the states in 41 Ar and 39 Ar have been extracted and are in fair agreement with those obtained by other workers. (Auth.)

  6. Jumps in binomial AR(1) processes

    OpenAIRE

    Weiß , Christian H.

    2009-01-01

    Abstract We consider the binomial AR(1) model for serially dependent processes of binomial counts. After a review of its definition and known properties, we investigate marginal and serial properties of jumps in such processes. Based on these results, we propose the jumps control chart for monitoring a binomial AR(1) process. We show how to evaluate the performance of this control chart and give design recommendations. correspondance: Tel.: +49 931 31 84968; ...

  7. Pig StAR: mRNA expression and alternative splicing in testis and Leydig cells, and association analyses with testicular morphology traits.

    Science.gov (United States)

    Zhang, Yanghai; Cui, Yang; Zhang, Xuelian; Wang, Yimin; Gao, Jiayang; Yu, Ting; Lv, Xiaoyan; Pan, Chuanying

    2018-05-31

    Steroidogenic acute regulatory protein (StAR), primarily expressed in Leydig cells (LCs) in the mammalian testes, is essential for testosterone biosynthesis and male fertility. However, no previous reports have explored the expression profiles, alternative splicing and genetic variations of StAR gene in pig. The aim of current study was to explore the expression profiles in different tissues and different types of testicular cells (LCs; spermatogonial stem cells, SSCs; Sertoli cells, SCs), to identify different splice variants and their expression levels, as well as to detect the indel polymorphism in pig StAR gene. Expression analysis results revealed that StAR was widely expressed in all tested tissues and the expression level in testis was significantly higher than that in other tissues (P StAR mRNA expression level was significantly higher in LCs than others (P StAR-a, StAR-b and StAR-c, were first found in pig. Further study showed StAR-a was highly expressed in both testis and LCs when compared with other variants (P StAR-a was the primary variant at StAR gene post-transcription and may facilitate the combination and transportation of cholesterol with StAR. In addition, a 5-bp duplicated deletion (NC_010457.5:g.5524-5528 delACTTG) was verified in the porcine StAR gene, which was closely related to male testicular morphology traits (P StAR gene might be a positive allele. Briefly, the current findings suggest that StAR and StAR-a play imperative roles in male fertility and the 5-bp indel can be a potential DNA marker for the marker-assisted selection in boar. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. AR4VI: AR as an Accessibility Tool for People with Visual Impairments.

    Science.gov (United States)

    Coughlan, James M; Miele, Joshua

    2017-10-01

    Although AR technology has been largely dominated by visual media, a number of AR tools using both visual and auditory feedback have been developed specifically to assist people with low vision or blindness - an application domain that we term Augmented Reality for Visual Impairment (AR4VI). We describe two AR4VI tools developed at Smith-Kettlewell, as well as a number of pre-existing examples. We emphasize that AR4VI is a powerful tool with the potential to remove or significantly reduce a range of accessibility barriers. Rather than being restricted to use by people with visual impairments, AR4VI is a compelling universal design approach offering benefits for mainstream applications as well.

  9. The effects of acid treatment and sample preparation on 40Ar/39Ar ages

    Science.gov (United States)

    Morgan, L. E.; Davidheiser, B.; Kuiper, K.; Wijbrans, J. R.

    2011-12-01

    Practitioners of K-Ar and 40Ar/39Ar geochronology regularly use dilute acids (typically 5-10% hydrofluoric acid (HF)) to clean mineral grains prior to irradiation (in the case of 40Ar/39Ar), and analysis (e.g. Evernden and Curtis, 1965; Dalrymple, 1967). This treatment has been shown to reduce contamination from atmospheric Ar, which consists largely of 40Ar and thus must be differentiated from radiogenic 40Ar* (Evernden and Curtis, 1965). Acid treatments can also remove fine grained material attached to mineral grains, such as glass shards or devitrified glass, which can affect analyses and is difficult to remove by other means (Evernden and Curtis, 1965). Such treatments were originally examined for their efficacy in reducing atmospheric argon contamination (Dalrymple, 1967) but were not assessed for the possibility of leaching Ar* or K differentially, which would affect both K-Ar and 40Ar/39Ar ages. Indeed, Evernden and Curtis (1965) state that they are simply removing the "outer portions of the crystals" and apparently do not account for the potential for leaching of 40Ar* or K from the mass of their host mineral. Moreover, the capabilities of the K-Ar system in the 1960s was limited to a precision of ca. 3-4% on samples of 1-3 Ma (Cox and Dalrymple, 1967). Effects of smaller magnitude could not have been detected at the time. As the developments of the 40Ar/39Ar system and modern mass spectrometer technology have allowed for precision to approach 0.1%, the potential effects of acid treatment during sample preparation warrant revisiting. Additionally, the use of Calgon for sample disintegration has not previously been quantitatively assessed but is used extensively in some laboratories. Here we present a series of experiments from co-irradiated Fish Canyon sanidine (FCs) and Mes-4 (Kuiper et al., 2008). FCs is used as the mineral standard following standard procedures. Mes-4 splits were treated with H2O (10 minutes, ultrasonic), Calgon (10%, overnight at 50

  10. Age measurements of potassium-bearing sulfide minerals by the 40Ar/39Ar technique

    International Nuclear Information System (INIS)

    Czamanske, G.K.; Lanphere, M.A.; Erd, R.C.; Blake, M.C. Jr.

    1978-01-01

    K-Ar ages have been determined for sulfide minerals for the first time. The occurrence of adequate amounts of potassium-bearing sulfides with ideal compositions K 3 Fe 10 S 14 (approximately 10 wt.% K) and KFe 2 S 3 (approximately 16 wt.% K) in samples from a mafic alkalic diatreme at Coyote Peak, California, prompted an attempt to date these materials. K 3 Fe 10 S 14 , a massive mineral with conchoidal fracture, gives an age of 29.4 +- 0.5 m.y. ( 40 Ar/ 39 Ar), indistinguishable from the 28.3 +- 0.4 m.y. ( 40 Ar/ 39 Ar) and 30.2 +- 1.0 m.y. (conventional K-Ar) ages obtained for associated phlogopite (8.7 wt.% K). KFe 2 S 3 , a bladed, fibrous sulfide, gives a younger age, 26.5 +- 0.5 m.y. ( 40 Ar/ 39 Ar), presumably owing to Ar loss. (Auth.)

  11. Geochronology and thermochronology by the sup 40 Ar/ sup 39 Ar method

    Energy Technology Data Exchange (ETDEWEB)

    McDougall, I. (Australian National Univ., Canberra (Australia)); Harrison, T.M. (State Univ. of New York, Albany, NY (USA))

    1988-01-01

    This work is a response to the authors' belief that there is a need for a monograph on {sup 40}Ar/{sup 39}Ar dating to provide concise knowledge concerning the application of this method to geological studies. They aim to provide a reasonably comprehensive but by no means exhaustive coverage of the principles and practices of {sup 40}Ar/{sup 39}Ar dating, with emphasis on interpretation of results. In attempting to provide an overview of the current state of knowledge, they commonly cite examples from the available literature. They draw rather heavily upon their own work, because they feel comfortable with their own examples. (author).

  12. 40Ar/39Ar age and thermal history of the Kirin chondrite

    International Nuclear Information System (INIS)

    Wang, S.; McDougall, I.; Tetley, N.; Harrison, T.M.

    1980-01-01

    The Kirin meteorite, a large (> 2800 kg) H5 chondrite, fell in Kirin Province, China in 1976. A sample from each of the two largest fragments (K-1. K-2) yield 40 Ar/ 39 Ar total fusion ages of 3.63 +- 0.02 b.y. and 2.78 +- 0.02 b.y. respectively. 40 Ar/ 40 Ar age spectra show typical diffusional argon loss profiles. Maximum apparent ages of 4.36 b.y. (K-1) and approx. 4.0 b.y. (K-2) are interpreted as possible minimum estimates for the age of crystallization of the parent body. (orig./ME)

  13. On the doubly ionized states of Ar2 and their intra- and interatomic decay to Ar23+

    International Nuclear Information System (INIS)

    Stoychev, Spas D.; Kuleff, Alexander I.; Tarantelli, Francesco; Cederbaum, Lorenz S.

    2008-01-01

    Potential energy curves of the Auger state Ar + (2p -1 )-Ar, the different one- and two-site dicationic states Ar 2 ++ (with energies in the range of 32-77 eV), and the lowest two-site tricationic states Ar ++ -Ar + (with energies in the range of 64-76 eV) computed using elaborated ab initio methods are reported. The accessible relaxation channels of the electronic states of Ar ++ -Ar populated by Auger decay are studied. In particular, we study in detail the interatomic Coulombic decay following the population of one-site satellite states of Ar ++ (3s -1 3p -1 )-Ar recently observed experimentally. Other relaxation pathways of Ar ++ -Ar, including radiative charge transfer, nuclear dynamics through curve crossing, and intra-atomic decay processes are also investigated

  14. Re-Scoring the Game’s Score

    DEFF Research Database (Denmark)

    Gasselseder, Hans-Peter

    2014-01-01

    This study explores immersive presence as well as emotional valence and arousal in the context of dynamic and non-dynamic music scores in the 3rd person action-adventure video game genre while also considering relevant personality traits of the player. 60 subjects answered self-report questionnai......This study explores immersive presence as well as emotional valence and arousal in the context of dynamic and non-dynamic music scores in the 3rd person action-adventure video game genre while also considering relevant personality traits of the player. 60 subjects answered self......-temporal alignment in the resulting emotional congruency of nondiegetic music. Whereas imaginary aspects of immersive presence are systemically affected by the presentation of dynamic music, sensory spatial aspects show higher sensitivity towards the arousal potential of the music score. It is argued...

  15. Modelling the ArH+ emission from the Crab nebula

    Science.gov (United States)

    Priestley, F. D.; Barlow, M. J.; Viti, S.

    2017-12-01

    We have performed combined photoionization and photodissociation region (PDR) modelling of a Crab nebula filament subjected to the synchrotron radiation from the central pulsar wind nebula, and to a high flux of charged particles; a greatly enhanced cosmic-ray ionization rate over the standard interstellar value, ζ0, is required to account for the lack of detected [C I] emission in published Herschel SPIRE FTS observations of the Crab nebula. The observed line surface brightness ratios of the OH+ and ArH+ transitions seen in the SPIRE FTS frequency range can only be explained with both a high cosmic-ray ionization rate and a reduced ArH+ dissociative recombination rate compared to that used by previous authors, although consistent with experimental upper limits. We find that the ArH+/OH+ line strengths and the observed H2 vibration-rotation emission can be reproduced by model filaments with nH = 2 × 104 cm-3, ζ = 107ζ0 and visual extinctions within the range found for dusty globules in the Crab nebula, although far-infrared emission from [O I] and [C II] is higher than the observational constraints. Models with nH = 1900 cm-3 underpredict the H2 surface brightness, but agree with the ArH+ and OH+ surface brightnesses and predict [O I] and [C II] line ratios consistent with observations. These models predict HeH+ rotational emission above detection thresholds, but consideration of the formation time-scale suggests that the abundance of this molecule in the Crab nebula should be lower than the equilibrium values obtained in our analysis.

  16. Classical treatment of Li2++Ar and He2++Ar collisions

    International Nuclear Information System (INIS)

    Jorge, A; Illescas, Clara; Pons, B

    2015-01-01

    Classical Trajectory Monte Carlo calculations are carried out for Li 2+ +Ar and He 2+ +Ar collisions, motivated by recent experiments on these systems. Cross sections for electron capture, projectile electron loss and target multiple ionization processes are evaluated and compared to the experimental values in the 75-500 keV/amy impact energy range. (paper)

  17. A refined astronomically calibrated 40Ar/39Ar age for Fish Canyon sanidine

    NARCIS (Netherlands)

    Rivera, T.A.; Storey, M.; Zeeden, C.; Hilgen, F.J.; Kuiper, K.

    2011-01-01

    Intercalibration between the astronomical and radio-isotopic dating methods provides a means to improving accuracy and reducing uncertainty of an integrated, multi-chronometer geologic timescale. Here we report a high-precision 40Ar/39Ar age for the FishCanyon sanidine (FCs) neutron fluence monitor,

  18. AR copy number and AR signaling-directed therapies in castration-resistant prostate cancer.

    Science.gov (United States)

    Salvi, Samanta; Conteduca, Vincenza; Lolli, Cristian; Testoni, Sara; Casadio, Valentina; Zaccheroni, Andrea; Rossi, Lorena; Burgio, Salvatore Luca; Menna, Cecilia; Schepisi, Giuseppe; De Giorgi, Ugo

    2017-11-22

    Adaptive upregulation of androgen receptor (AR) is the most common event involved in the progression from hormone sensitive to castration-resistant prostate cancer (CRPC). AR signaling remains the main target of new AR signalling-directed therapies such as abiraterone and enzalutamide in CRPC patients. In this review, we discuss general mechanisms of resistance to AR-targeted therapies, with a focus on the role of AR copy number (CN). We reported methods and clinical applications of AR CN evaluation in tissue and liquid biopsy, thus to have a complete information regarding its role as predictive and prognostic biomarker. Outcomes of CRPC patients are reported to be highly variable as consequence of tumor heterogeneity. AR CN could contribute to patient selection and tumor monitoring in CRPC treated with new anti-cancer treatment as abiraterone and enzalutamide. Further studies to investigate AR CN effect to these agents and its potential combination with other prognostic or predictive clinical factors are necessary in the context of harmonized clinical trial design. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Support for the Astronomically Calibrated 40Ar/39Ar Age of Fish Canyon Sanidine

    DEFF Research Database (Denmark)

    Rivera, Tiffany; Storey, Michael; Zeeden, Christian

    2011-01-01

    al. (2008) determined an astronomically calibrated 40Ar/39Ar age of 28.201 0.046 Ma (2), relative to the indirect astronomically tuned Moroccan Melilla Basin Messâdit section. Here, we provide independent verification for the Kuiper, et al. (2008) FCs age using sanidines extracted from the A1 tephra...

  20. Degradation Assessment and Fault Diagnosis for Roller Bearing Based on AR Model and Fuzzy Cluster Analysis

    Directory of Open Access Journals (Sweden)

    Lingli Jiang

    2011-01-01

    Full Text Available This paper proposes a new approach combining autoregressive (AR model and fuzzy cluster analysis for bearing fault diagnosis and degradation assessment. AR model is an effective approach to extract the fault feature, and is generally applied to stationary signals. However, the fault vibration signals of a roller bearing are non-stationary and non-Gaussian. Aiming at this problem, the set of parameters of the AR model is estimated based on higher-order cumulants. Consequently, the AR parameters are taken as the feature vectors, and fuzzy cluster analysis is applied to perform classification and pattern recognition. Experiments analysis results show that the proposed method can be used to identify various types and severities of fault bearings. This study is significant for non-stationary and non-Gaussian signal analysis, fault diagnosis and degradation assessment.

  1. Atmospheric pressure plasma jet utilizing Ar and Ar/H2O mixtures and its applications to bacteria inactivation

    International Nuclear Information System (INIS)

    Cheng Cheng; Shen Jie; Xiao De-Zhi; Xie Hong-Bing; Lan Yan; Fang Shi-Dong; Meng Yue-Dong; Chu Paul K

    2014-01-01

    An atmospheric pressure plasma jet generated with Ar with H 2 O vapor is characterized and applied to inactivation of Bacillus subtilis spores. The emission spectra obtained from Ar/H 2 O plasma shows a higher intensity of OH radicals compared to pure argon at a specified H 2 O concentration. The gas temperature is estimated by comparing the simulated spectra of the OH band with experimental spectra. The excitation electron temperature is determined from the Boltzmann's plots and Stark broadening of the hydrogen Balmer H β line is applied to measure the electron density. The gas temperature, excitation electron temperature, and electron density of the plasma jet decrease with the increase of water vapor concentration at a fixed input voltage. The bacteria inactivation rate increases with the increase of OH generation reaching a maximum reduction at 2.6% (v/v) water vapor. Our results also show that the OH radicals generated by the Ar/H 2 O plasma jet only makes a limited contribution to spore inactivation and the shape change of the spores before and after plasma irradiation is discussed. (physics of gases, plasmas, and electric discharges)

  2. Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction.

    Science.gov (United States)

    Xu, Defeng; Chen, Qiulu; Liu, Yalin; Wen, Xingqiao

    2017-12-01

    Androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Androgen deprivation therapy with antiandrogens to reduce androgen biosynthesis or prevent androgens from binding to AR are widely used to suppress AR-mediated PCa growth. However, most of ADT may eventually fail with development of the castration resistance after 12-24 months. Here we found that a natural product baicalein can effectively suppress the PCa progression via targeting the androgen-induced AR transactivation with little effect to AR protein expression. PCa cells including LNCaP, CWR22Rv1, C4-2, PC-3, and DU145, were treated with baicalein and luciferase assay was used to evaluate their effect on the AR transactivation. Cell growth and IC 50 were determined by MTT assay after 48 hrs treatment. RT-PCR was used to evaluate the mRNA levels of AR target genes including PSA, TMPRSS2, and TMEPA1. Western blot was used to determine AR and PSA protein expression. The natural product of baicalein can selectively inhibit AR transactivation with little effect on the other nuclear receptors, including ERα, and GR. At a low concentration, 2.5 μM of baicalein effectively suppresses the growth of AR-positive PCa cells, and has little effect on AR-negative PCa cells. Mechanism dissection suggest that baicalein can suppress AR target genes (PSA, TMPRSS2, and TMEPA1) expression in both androgen responsive LNCaP cells and castration resistant CWR22Rv1 cells, that may involve the inhibiting the AR N/C dimerization and AR-coactivators interaction. Baicalein may be developed as an effective anti-AR therapy via its ability to inhibit AR transactivation and AR-mediated PCa cell growth.

  3. Ar-41 measurements and nuclear emergency preparedness

    International Nuclear Information System (INIS)

    Kunst, J.J.; Rodriguez, M.; Ugarte, R.; Vigile, R.S.; Boutet, L.I.; Jordan, O.D.; Hernandez, D.G.

    2010-01-01

    During the early phase of an emergency is necessary to confirm the release of radioactivity predictions made by the operator of the nuclear plant. In this context, it has begun measuring Ar-41 in the vicinity of a research reactor. Since the Ar-41 is produced in the reactor, it has been studied as a good way to validate the air dispersion model used in nuclear emergencies and to develop a method to improve the characterization of the release. For this latter purpose a pilot experiment was conducted to determine computational and experimental methods, the flux of 1.29 MeV of Ar-41 and compared to evaluate the accuracy of the assessments made. This paper describes meteorological forecasting systems used in the experiment, the estimate of the stability class and the concentration of nuclides using a calculation code developed by the ARN, as well as the methodology and equipment used for measurement in the field. (authors) [es

  4. AR(p) -based detrended fluctuation analysis

    Science.gov (United States)

    Alvarez-Ramirez, J.; Rodriguez, E.

    2018-07-01

    Autoregressive models are commonly used for modeling time-series from nature, economics and finance. This work explored simple autoregressive AR(p) models to remove long-term trends in detrended fluctuation analysis (DFA). Crude oil prices and bitcoin exchange rate were considered, with the former corresponding to a mature market and the latter to an emergent market. Results showed that AR(p) -based DFA performs similar to traditional DFA. However, the former DFA provides information on stability of long-term trends, which is valuable for understanding and quantifying the dynamics of complex time series from financial systems.

  5. Let's Get Higher Scores on These New Assessments

    Science.gov (United States)

    Shanahan, Timothy

    2015-01-01

    This column explains three ways that teachers can improve reading test performance. Basically, the idea is that instead of teaching students to respond to particular question types as is typical of test preparation despite the ineffectiveness of this practice, it is better to teach students to read the test passages more effectively. Three…

  6. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

    International Nuclear Information System (INIS)

    Brennan, Donal J; Jirstrom, Karin; Brändstedt, Jenny; Rexhepaj, Elton; Foley, Michael; Pontén, Fredrik; Uhlén, Mathias; Gallagher, William M; O'Connor, Darran P; O'Herlihy, Colm

    2010-01-01

    Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens

  7. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.

    LENUS (Irish Health Repository)

    Brennan, Donal J

    2010-01-01

    BACKGROUND: Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. METHODS: HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). RESULTS: Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. CONCLUSION: HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.

  8. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

    LENUS (Irish Health Repository)

    Brennan, Donal J

    2010-04-01

    Abstract Background Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. Methods HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). Results Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. Conclusion HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.

  9. How to score questionnaires

    NARCIS (Netherlands)

    Hofstee, W.K.B.; Ten Berge, J.M.F.; Hendriks, A.A.J.

    The standard practice in scoring questionnaires consists of adding item scores and standardizing these sums. We present a set of alternative procedures, consisting of (a) correcting for the acquiescence variance that disturbs the structure of the questionnaire; (b) establishing item weights through

  10. SCORE - A DESCRIPTION.

    Science.gov (United States)

    SLACK, CHARLES W.

    REINFORCEMENT AND ROLE-REVERSAL TECHNIQUES ARE USED IN THE SCORE PROJECT, A LOW-COST PROGRAM OF DELINQUENCY PREVENTION FOR HARD-CORE TEENAGE STREET CORNER BOYS. COMMITTED TO THE BELIEF THAT THE BOYS HAVE THE POTENTIAL FOR ETHICAL BEHAVIOR, THE SCORE WORKER FOLLOWS B.F. SKINNER'S THEORY OF OPERANT CONDITIONING AND REINFORCES THE DELINQUENT'S GOOD…

  11. Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer.

    Science.gov (United States)

    Zhu, Yezi; Sharp, Adam; Anderson, Courtney M; Silberstein, John L; Taylor, Maritza; Lu, Changxue; Zhao, Pei; De Marzo, Angelo M; Antonarakis, Emmanuel S; Wang, Mindy; Wu, Xingyong; Luo, Yuling; Su, Nan; Nava Rodrigues, Daniel; Figueiredo, Ines; Welti, Jonathan; Park, Emily; Ma, Xiao-Jun; Coleman, Ilsa; Morrissey, Colm; Plymate, Stephen R; Nelson, Peter S; de Bono, Johann S; Luo, Jun

    2018-05-01

    Androgen receptor splice variant 7 (AR-V7) has been implicated in resistance to abiraterone and enzalutamide treatment in men with metastatic castration-resistant prostate cancer (mCRPC). Tissue- or cell-based in situ detection of AR-V7, however, has been limited by lack of specificity. To address current limitations in precision measurement of AR-V7 by developing a novel junction-specific AR-V7 RNA in situ hybridization (RISH) assay compatible with automated quantification. We designed a RISH method to visualize single splice junctions in cells and tissue. Using the validated assay for junction-specific detection of the full-length AR (AR-FL) and AR-V7, we generated quantitative data, blinded to clinical data, for 63 prostate tumor biopsies. We evaluated clinical correlates of AR-FL/AR-V7 measurements, including association with prostate-specific antigen progression-free survival (PSA-PFS) and clinical and radiographic progression-free survival (PFS), in a subset of patients starting treatment with abiraterone or enzalutamide following biopsy. Quantitative AR-FL/AR-V7 data were generated from 56 of the 63 (88.9%) biopsy specimens examined, of which 44 were mCRPC biopsies. Positive AR-V7 signals were detected in 34.1% (15/44) mCRPC specimens, all of which also co-expressed AR-FL. The median AR-V7/AR-FL ratio was 11.9% (range 2.7-30.3%). Positive detection of AR-V7 was correlated with indicators of high disease burden at baseline. Among the 25 CRPC biopsies collected before treatment with abiraterone or enzalutamide, positive AR-V7 detection, but not higher AR-FL, was significantly associated with shorter PSA-PFS (hazard ratio 2.789, 95% confidence interval 1.12-6.95; p=0.0081). We report for the first time a RISH method for highly specific and quantifiable detection of splice junctions, allowing further characterization of AR-V7 and its clinical significance. Higher AR-V7 levels detected and quantified using a novel method were associated with poorer response to

  12. An Objective Fluctuation Score for Parkinson's Disease

    Science.gov (United States)

    Horne, Malcolm K.; McGregor, Sarah; Bergquist, Filip

    2015-01-01

    Introduction Establishing the presence and severity of fluctuations is important in managing Parkinson’s Disease yet there is no reliable, objective means of doing this. In this study we have evaluated a Fluctuation Score derived from variations in dyskinesia and bradykinesia scores produced by an accelerometry based system. Methods The Fluctuation Score was produced by summing the interquartile range of bradykinesia scores and dyskinesia scores produced every 2 minutes between 0900-1800 for at least 6 days by the accelerometry based system and expressing it as an algorithm. Results This Score could distinguish between fluctuating and non-fluctuating patients with high sensitivity and selectivity and was significant lower following activation of deep brain stimulators. The scores following deep brain stimulation lay in a band just above the score separating fluctuators from non-fluctuators, suggesting a range representing adequate motor control. When compared with control subjects the score of newly diagnosed patients show a loss of fluctuation with onset of PD. The score was calculated in subjects whose duration of disease was known and this showed that newly diagnosed patients soon develop higher scores which either fall under or within the range representing adequate motor control or instead go on to develop more severe fluctuations. Conclusion The Fluctuation Score described here promises to be a useful tool for identifying patients whose fluctuations are progressing and may require therapeutic changes. It also shows promise as a useful research tool. Further studies are required to more accurately identify therapeutic targets and ranges. PMID:25928634

  13. 40Ar/36Ar in MORB glasses: Constraints on atmosphere and mantle evolution

    International Nuclear Information System (INIS)

    Sarda, P.; Staudacher, T.; Allegre, C.J.; Paris-7 Univ., 75

    1985-01-01

    Argon isotopic composition measurements of MORB glassy samples from the Pacific, Atlantic and Indian Oceans are performed. There is a very large scatter in the 40 Ar/ 36 Ar ratio, from 980 up to 24,400 for bulk rock analyses, which is mainly due to atmospheric contamination: Using the stepwise heating technique, very high ratios are obtained, from 15,000 up to 25,250 which is the highest 40 Ar/ 36 Ar ratio ever measured in MORB. We establish a negative correlation between the highest 40 Ar/ 36 Ar results from stepwise heating and 87 Sr/ 86 Sr ratios, which is perfectly consistent with a two-layered mantle structure. From both 40 Ar and 129 Xe MORB systematics a model is proposed for the kinetics of degassing: a very early and extensive burst, with a time constant of approx.= 4 My, is followed by a slower process of present day type, with a time constant of approx.= 0.5 Gy. The mean age of the atmosphere is so determined to be around 4.4 Gy. (orig./WB)

  14. Electron impact ionization of Ar8+

    International Nuclear Information System (INIS)

    Defrance, P.; Rachafi, S.; Jureta, J.; Meyer, F.; Chantrenne, S.

    1986-01-01

    Absolute electron impact ionization cross-sections have been measured for the Neon-like Ar 8+ in the energy range from below the threshold for the metastable state to 2500 eV. No contribution of metastable states is observed. The results are well reproduced by the Distorted Wave Born Approximation. 12 refs., 1 fig

  15. 75 FR 7637 - Arkansas Disaster #AR-00040

    Science.gov (United States)

    2010-02-22

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12031 and 12032] Arkansas Disaster AR-00040 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Arkansas dated 02/10/2010. Incident: Severe Storms and...

  16. 76 FR 42155 - Arkansas Disaster #AR-00051

    Science.gov (United States)

    2011-07-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12680 and 12681] Arkansas Disaster AR-00051 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas (FEMA- 4000-DR), dated 07...

  17. 75 FR 7636 - Arkansas Disaster #AR-00042

    Science.gov (United States)

    2010-02-22

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12034 and 12035] Arkansas Disaster AR-00042 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas (FEMA-- 1872--DR), dated...

  18. 76 FR 42154 - Arkansas Disaster #AR-00050

    Science.gov (United States)

    2011-07-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12678 and 12679] Arkansas Disaster AR-00050 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-4000-DR), dated 07/08/2011. Incident: Severe...

  19. 75 FR 30872 - Arkansas Disaster # AR-00043

    Science.gov (United States)

    2010-06-02

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12196 and 12197] Arkansas Disaster AR-00043 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Arkansas dated 05/26/2010. Incident: Severe storms, tornadoes and...

  20. 78 FR 39821 - Arkansas Disaster #AR-00064

    Science.gov (United States)

    2013-07-02

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13637 and 13638] Arkansas Disaster AR-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas (FEMA- 4124-DR), dated 06...

  1. 76 FR 27140 - Arkansas Disaster # AR-00049

    Science.gov (United States)

    2011-05-10

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas (FEMA- 1975-DR), dated 05...

  2. 78 FR 9448 - Arkansas Disaster #AR-00061

    Science.gov (United States)

    2013-02-08

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13473 and 13474] Arkansas Disaster AR-00061 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas (FEMA- 4100-DR), dated 01...

  3. 76 FR 27139 - Arkansas Disaster #AR-00048

    Science.gov (United States)

    2011-05-10

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02/2011. Incident: Severe...

  4. "ARS 01", perspektiivide avamine / Helen Kivisoo

    Index Scriptorium Estoniae

    Kivisoo, Helen

    2001-01-01

    30. IX 2001-20. I 2002 Kiasmas kuuendat korda toimuvast rahvusvahelisest näitusest "ARS", kus Eestist osaleb Marko Mäetamm. Kuraatorid Tuula Arkio, Maaretta Jaukkuri, Patrik Nyberg, Jari-Pekka Vanhala. Teemaks "kolmas ruum". Näituse kajastamisest.

  5. Hazard evaluation for 244-AR vault facility

    International Nuclear Information System (INIS)

    BRAUN, D.J.

    1999-01-01

    This document presents the results of a hazard identification and evaluation performed on the 244-AR Vault Facility to close a USQ (USQ No. TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed in HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities

  6. A compilation of {sup 40}Ar-{sup 39} and K-Ar ages: report 25

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, P A [Geological Survey of Canada, Ottawa, ON (Canada); Roddick, J C

    1997-12-31

    Twenty-three {sup 40}Ar-{sup 39}Ar age determinations (including two potassium-argon analyses) carried out by the Geological Survey of Canada are reported. Each age determination is accompanied by a description of the rock and mineral concentrate used; brief interpretative comments regarding the geological significance of each age are also provided where possible. The experimental procedures employed are described in outline. An index of all Geological Survey of Canada K-Ar age determinations published in this format has been prepared using NTS quadrangles as the primary reference. (author). 6 refs., 2 tabs., 1 fig.

  7. A compilation of 40Ar-39 and K-Ar ages: report 25

    International Nuclear Information System (INIS)

    Hunt, P.A.; Roddick, J.C.

    1996-01-01

    Twenty-three 40 Ar- 39 Ar age determinations (including two potassium-argon analyses) carried out by the Geological Survey of Canada are reported. Each age determination is accompanied by a description of the rock and mineral concentrate used; brief interpretative comments regarding the geological significance of each age are also provided where possible. The experimental procedures employed are described in outline. An index of all Geological Survey of Canada K-Ar age determinations published in this format has been prepared using NTS quadrangles as the primary reference. (author). 6 refs., 2 tabs., 1 fig

  8. The ChArMEx database

    Science.gov (United States)

    Ferré, Hélène; Belmahfoud, Nizar; Boichard, Jean-Luc; Brissebrat, Guillaume; Cloché, Sophie; Descloitres, Jacques; Fleury, Laurence; Focsa, Loredana; Henriot, Nicolas; Mière, Arnaud; Ramage, Karim; Vermeulen, Anne; Boulanger, Damien

    2015-04-01

    The Chemistry-Aerosol Mediterranean Experiment (ChArMEx, http://charmex.lsce.ipsl.fr/) aims at a scientific assessment of the present and future state of the atmospheric environment in the Mediterranean Basin, and of its impacts on the regional climate, air quality, and marine biogeochemistry. The project includes long term monitoring of environmental parameters , intensive field campaigns, use of satellite data and modelling studies. Therefore ChARMEx scientists produce and need to access a wide diversity of data. In this context, the objective of the database task is to organize data management, distribution system and services, such as facilitating the exchange of information and stimulating the collaboration between researchers within the ChArMEx community, and beyond. The database relies on a strong collaboration between ICARE, IPSL and OMP data centers and has been set up in the framework of the Mediterranean Integrated Studies at Regional And Locals Scales (MISTRALS) program data portal. ChArMEx data, either produced or used by the project, are documented and accessible through the database website: http://mistrals.sedoo.fr/ChArMEx. The website offers the usual but user-friendly functionalities: data catalog, user registration procedure, search tool to select and access data... The metadata (data description) are standardized, and comply with international standards (ISO 19115-19139; INSPIRE European Directive; Global Change Master Directory Thesaurus). A Digital Object Identifier (DOI) assignement procedure allows to automatically register the datasets, in order to make them easier to access, cite, reuse and verify. At present, the ChArMEx database contains about 120 datasets, including more than 80 in situ datasets (2012, 2013 and 2014 summer campaigns, background monitoring station of Ersa...), 25 model output sets (dust model intercomparison, MEDCORDEX scenarios...), a high resolution emission inventory over the Mediterranean... Many in situ datasets

  9. 40Ar/39Ar dating of Quaternary volcanic ashes by multi-collection noble gas mass spectrometry: protocols, precision and intercalibration

    DEFF Research Database (Denmark)

    Storey, Michael; Rivera, Tiffany; Flude, Stephanie

    ) higher mass resolution allows hydrocarbon interferences to be pseudo resolved for the different argon isotopes; and (iv) multi-collection, allowing more data to be gathered in a fixed time in comparison with single-collector peak-switching measurements. We evaluate (i) protocols for detector inter......The recent availability of commercial high-resolution, multi-collector, noble gas mass spectrometers equipped with ion-counting electron multipliers provides new opportunities for improved precision in 40Ar/39Ar dating. This is particularly true for single crystal dating of Quaternary aged samples...... where potassium-bearing phenocrysts may contain relatively small amounts of radiogenic 40Ar. In 2005, the Quaternary Dating Laboratory, Roskilde University, installed a Nu-Instruments multi-collector Noblesse noble gas mass spectrometer, which is configured with a Faraday detector and three ion...

  10. Postcollision interactions in the Auger decay of the Ar L-shell

    Energy Technology Data Exchange (ETDEWEB)

    Samson, J.A.R.; Stolte, W.C.; He, Z.X. [Univ. of Nebraska, Lincoln, NE (United States)] [and others

    1997-04-01

    The photoionization cross sections for Ar{sup +} through Ar{sup 4+}, produced by the Auger decay of an inner shell 2p hole, have been measured between 242 eV and 253 eV on beamline 9.0.1 and 6.3.2. In this study the authors are interested in near threshold phenomenon involving postcollision interactions (PCI), which are related to the Auger decay of a vacancy in the Ar L-shell. During an Auger decay a postcollision interaction can occur causing the out-going photoelectron to be retarded thus losing a certain amount of energy. If the retardation is sufficiently large the photoelectron will not escape. This result produces a singly charged ion, which normally would not be present. Such evidence of electron capture by the PCI effect was first shown clearly by Eberhardt et al. and, with higher resolution, in the present work. However, capture of the photoelectron is expected to be 100% exactly at the L{sub 2,3} thresholds. Thus, from the authors results they would have expected the Ar{sup 2+} signal to be zero at threshold, but it was not? The authors can explain this anomoly on the basis that during the Auger decay the photoelectrons are captured into high lying excited states of Ar{sup +}, which subsequently decay through autoionization yielding Ar{sup 2+}. Future work in this area will seek experimental evidence to verify this prediction.

  11. Beam-induced back-streaming electron suppression analysis for an accelerator type neutron generator designed for 40Ar/39Ar geochronology.

    Science.gov (United States)

    Waltz, Cory; Ayllon, Mauricio; Becker, Tim; Bernstein, Lee; Leung, Ka-Ngo; Kirsch, Leo; Renne, Paul; Bibber, Karl Van

    2017-07-01

    A facility based on a next-generation, high-flux D-D neutron generator has been commissioned and it is now operational at the University of California, Berkeley. The current generator designed for 40 Ar/ 39 Ar dating of geological materials produces nearly monoenergetic 2.45MeV neutrons at outputs of 10 8 n/s. The narrow energy range is advantageous relative to the 235 U fission spectrum neutrons due to (i) reduced 39 Ar recoil energy, (ii) minimized production of interfering argon isotopes from K, Ca, and Cl, and (iii) reduced total activity for radiological safety and waste generation. Calculations provided show that future conditioning at higher currents and voltages will allow for a neutron output of over 10 10 n/s, which is a necessary requirement for production of measurable quantities of 39 Ar through the reaction 39 K(n,p) 39 Ar. A significant problem encountered with increasing deuteron current was beam-induced electron backstreaming. Two methods of suppressing secondary electrons resulting from the deuterium beam striking the target were tested: the application of static electric and magnetic fields. Computational simulations of both techniques were done using a finite element analysis in COMSOL Multiphysics ® . Experimental tests verified these simulations. The most reliable suppression was achieved via the implementation of an electrostatic shroud with a voltage offset of -800V relative to the target. Copyright © 2017. Published by Elsevier Ltd.

  12. VLA radio observations of AR Scorpii

    Science.gov (United States)

    Stanway, E. R.; Marsh, T. R.; Chote, P.; Gänsicke, B. T.; Steeghs, D.; Wheatley, P. J.

    2018-03-01

    Aims: AR Scorpii is unique amongst known white dwarf binaries in showing powerful pulsations extending to radio frequencies. Here we aim to investigate the multi-frequency radio emission of AR Sco in detail, in order to constrain its origin and emission mechanisms. Methods: We present interferometric radio frequency imaging of AR Sco at 1.5, 5 and 9 GHz, analysing the total flux and polarization behaviour of this source at high time resolution (10, 3 and 3 s), across a full 3.6 h orbital period in each band. Results: We find strong modulation of the radio flux on the orbital period and the orbital sideband of the white dwarf's spin period (also known as the "beat" period). This indicates that, like the optical flux, the radio flux arises predominantly from on or near the inner surface of the M-dwarf companion star. The beat-phase pulsations of AR Sco decrease in strength with decreasing frequency. They are strongest at 9 GHz and at an orbital phase 0.5. Unlike the optical emission from this source, radio emission from AR Sco shows weak linear polarization but very strong circular polarization, reaching 30% at an orbital phase 0.8. We infer the probable existence of a non-relativistic cyclotron emission component, which dominates at low radio frequencies. Given the required magnetic fields, this also likely arises from on or near the M-dwarf. A table of the flux time series is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/611/A66

  13. Intelligence Score Profiles of Female Juvenile Offenders

    Science.gov (United States)

    Werner, Shelby Spare; Hart, Kathleen J.; Ficke, Susan L.

    2016-01-01

    Previous studies have found that male juvenile offenders typically obtain low scores on measures of intelligence, often with a pattern of higher scores on measures of nonverbal relative to verbal tasks. The research on the intelligence performance of female juvenile offenders is limited. This study explored the Wechsler Intelligence Scale for…

  14. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina

    2013-01-01

    Background: This study was carried out in Guinea-Bissau ’ s capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method : From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  15. In-situ 40Ar/39Ar Laser Probe Dating of Micas from Mae Ping Shear Zone, Northern Thailand

    Science.gov (United States)

    Lin, Y. L.; Yeh, M. W.; Lo, C. H.; Lee, T. Y.; Charusiri, P.

    2012-04-01

    The Mae Ping Shear Zone (MPSZ, also known as Wang Chao Fault Zone), which trends NW-SE from Myanmar to central Thailand, was considered as the southern boundary of the SE extrusion of Indochina and Sibumasu block during the Cenozoic escape tectonic event of SE asia. Many analyses of 40Ar/39Ar dating on biotite and K-feldspar, K/Ar dating on biotite and illite, zircon fission-track and apatite fission-track dating had been accomplished to constrain the shearing period. Nevertheless, it is hard to convince that the ages could represent the end of the shearing since none of the dated minerals have been proved to be crystallized syn-tectonically. Meta-granitoid and gneiss from the MPSZ were analyzed in this study by applying in-situ 40Ar/39Ar laser probe dating with combination of petrology and micro-structural analysis in the purpose to decipher the geological significance of the dates. Plagioclase was replacing K-feldspar for K-feldspar was cut and embayed by plagioclase observed by SEM + EDS. Muscovite in the granitoid own fish shapes of sinistral sense of shearing, and are always in contact with plagioclase and quartz, which suggests that the muscovite crystallized from the dissolving K-feldspar under amphibolite facies condition. 117 spots on 12 muscovite fishes yield ages from 44 Ma to 35 Ma and have a mean age of 40 Ma. Since the growth condition of the muscovite is higher than the closure temperature, thus we can interpret these muscovite ages as cooling ages. Hence left-lateral shearing of the MPSZ can be deduced as syn- to post-muscovite growth and uplifted the crystalline rocks within the shear zone. The ages of matrix biotite in gneiss has a mean age of 35 Ma, which is consistent with the cooling path reconstructed from previous studies. While the ages of inclusion biotite in the K-feldspar phenocryst scatter from 40 to 50 Ma due to the isotopes were not totally re-equilibrated during the shearing. Consequently, the left-lateral shearing of the MPSZ was

  16. DNA damages induced by Ar F laser

    Energy Technology Data Exchange (ETDEWEB)

    Chapel, C.; Rose, S.; Chevrier, L.; Cordier, E.; Courant, D. [CEA Fontenay-aux-Roses, 92 (France). Dept. de Radiobiologie et de Radiopathologie

    2006-07-01

    The photo ablation process used in corneal refractive surgery by the Argon Fluoride (Ar F) laser emitting in ultraviolet C at 193 nm, exposes viable cells round the irradiated zone to sub ablative doses (< 400 joules.m -2). Despite that DNA absorption is higher at 193 nm than 254 nm, cytotoxicity of 193 nm laser radiation is lower than radiation emitted by 254 nm UV-C lamps. In situ, DNA could be protected of laser radiation by cellular components. Consequently, some authors consider that this radiation does not induce genotoxic effect whereas others suspect it to be mutagenic. These lasers are used for fifteen years but many questions remain concerning the long term effects on adjacent cells to irradiated area. The purpose of this study is to describe the effect of 193 nm laser radiation on DNA of stromal keratocytes which are responsible of the corneal structure. The 193 nm laser irradiation induces directly DNA breakage in keratocytes as it has been shown by the comet assay under alkaline conditions. Two hours post irradiation, damages caused by the highest exposure (150 J.m-2) are not repaired as it has been measured with the Olive Tail Moment (product of tail length and tail DNA content). They give partly evidence of induction of an apoptotic process in cells where DNA could be too damaged. In order to characterize specifically double strand breaks, a comparative analysis by immunofluorescence of the H2 Ax histone phosphorylation (H2 Ax) has been performed on irradiated keratocytes and unirradiated keratocytes. Results show a dose dependent increase of the number of H2 Ax positive cells. Consequences of unrepaired DNA lesions could be observed by the generation of micronuclei in cells. Results show again an increase of micronuclei in laser irradiated cells. Chromosomal aberrations have been pointed out by cytogenetic methods 30 mn after irradiation. These aberrations are dose dependent (from 10 to 150 J.m-2). The number of breakage decreases in the long run

  17. /sup 40/Ar//sup 39/Ar and K-Ar dating of altered glassy volcanic rocks: the Dabi Volcanics, P. N. G

    Energy Technology Data Exchange (ETDEWEB)

    Walker, D.A. (Australian National Univ., Canberra. Dept. of Geology); McDougall, I. (Australian National Univ., Canberra. Research School of Earth Sciences)

    1982-11-01

    K-Ar and /sup 40/Ar//sup 39/Ar ages have been determined for altered submarine tholeiitic and boninite (high-Mg andesite) lavas from the Dabi Volcanics, Cape Vogel Peninsula, Papua New Guinea. /sup 40/Ar//sup 39/Ar whole rock total fusion and plateau ages identify a Late Paleocene age for the tholeiitic lavas (58.9 +- 1.1 Ma), and also for the boninitic lavas (58.8 +- 0.8 Ma). Apparent K-Ar ages for the same samples range from 27.2 +- 0.7 to 63.9 +- 4.5 Ma, and young K-Ar ages for glassy boninites are probably due to variable radiogenic /sup 40/Ar(/sup 40/Ar*) loss. These new ages effectively reconcile previously ambiguous age data for the Dabi Volcanics, and indicate contemporaneous tholeiitic and boninitic volcanism occurring in southeast PNG during the Late Paleocene. Smectites, developed as alteration products after glass in oceanic lavas commonly do not retain /sup 39/Ar during or subsequent to irradiation, but in some cases may contain /sup 40/Ar*. The results are discussed.

  18. 40Ar/39Ar and K-Ar dating of altered glassy volcanic rocks: the Dabi Volcanics, P.N.G

    International Nuclear Information System (INIS)

    Walker, D.A.; McDougall, I.

    1982-01-01

    K-Ar and 40 Ar/ 39 Ar ages have been determined for altered submarine tholeiitic and boninite (high-Mg andesite) lavas from the Dabi Volcanics, Cape Vogel Peninsula, Papua New Guinea. 40 Ar/ 39 Ar whole rock total fusion and plateau ages identify a Late Paleocene age for the tholeiitic lavas (58.9 +- 1.1 Ma), and also for the boninitic lavas (58.8 +- 0.8 Ma). Apparent K-Ar ages for the same samples range from 27.2 +- 0.7 to 63.9 +- 4.5 Ma, and young K-Ar ages for glassy boninites are probably due to variable radiogenic 40 Ar( 40 Ar*) loss. These new ages effectively reconcile previously ambiguous age data for the Dabi Volcanics, and indicate contemporaneous tholeiitic and boninitic volcanism occurring in southeast PNG during the Late Paleocene. Smectites, developed as alteration products after glass in oceanic lavas commonly do not retain 39 Ar during or subsequent to irradiation, but in some cases may contain 40 Ar*. The results are discussed. (author)

  19. Volleyball Scoring Systems.

    Science.gov (United States)

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  20. A Refined Astronomically Calibrated 40Ar/39Ar Age for Fish Canyon Sanidine

    DEFF Research Database (Denmark)

    Rivera, Tiffany; Storey, Michael; Zeeden, Christian

    2011-01-01

    Intercalibration between the astronomical and radio-isotopic dating methods provides a means to improving accuracy and reducing uncertainty of an integrated, multi-chronometer geologic timescale. Here we report a high-precision 40Ar/39Ar age for the Fish Canyon sanidine (FCs) neutron fluence...... sanidine age of 0.7674±0.0022 Ma (2σ, external errors) is indistinguishable from the ID-TIMS U/Pb zircon age (0.7671±0.0019 Ma). The consistency between the astronomically calibrated 40Ar/39Ar sanidine age and U/Pb zircon age for this Quaternary unit suggests that agreement between these two radio-isotopic...... dating techniques is now achievable at better than±0.3% (2σ) in the youngest part of geologic time (

  1. 40Ar-39Ar age studies for tectonics of the Gondwana land

    International Nuclear Information System (INIS)

    Takigami, Yutaka; Sugiura, Naoji.

    1997-01-01

    40 Ar- 39 Ar age studies have been performed for samples from Antarctica and India which were parts of the Gondwana land at Mesozoic and Paleozoic time in order to investigate their thermal history and tectonic movement. From the both areas, ages of about 500 Ma which have been considered to be the age of Pan-African Orogeny were obtained, which represents that this thermal event spread widely over the Gondwana land. (author)

  2. Single grains, thermal histories, and the 40Ar/39Ar method

    International Nuclear Information System (INIS)

    Wright, Norrie

    1989-01-01

    A key part in unraveling the history of the physical evolution of the earth is knowledge of the earth's thermal history. 40 Ar/ 39 Ar step heating of mineral samples provides a means of defining a local thermal history. to do this accurately the challenge is to extract meaningful diffusion parameters from a mineral's Arrhenius plot. In the case of biotite single grains, where the laboratory release of argon is a complex process, this can be a difficult task. (12 refs., 5 figs.)

  3. ^<40>Ar-^<39>Ar Age Studies for Tectonics of the Gondwana Land

    OpenAIRE

    Takigami, Yutaka; Sugiura, Naoji

    1997-01-01

    ^Ar-^Ar age studies have been performed for samples from Antarctica and India which were parts of the Gondwana land at Mesozoic and Paleozoic time in order to investigate their thermal history and tectonic movement. From the both areas, ages of about 500 Ma which have been considered to be the age of Pan-African Orogeny were obtained, which represents that this thermal event spread widely over the Gondwana land.

  4. The ChArMEx database

    Science.gov (United States)

    Ferré, Hélène; Descloitres, Jacques; Fleury, Laurence; Boichard, Jean-Luc; Brissebrat, Guillaume; Focsa, Loredana; Henriot, Nicolas; Mastrorillo, Laurence; Mière, Arnaud; Vermeulen, Anne

    2013-04-01

    The Chemistry-Aerosol Mediterranean Experiment (ChArMEx, http://charmex.lsce.ipsl.fr/) aims at a scientific assessment of the present and future state of the atmospheric environment in the Mediterranean Basin, and of its impacts on the regional climate, air quality, and marine biogeochemistry. The project includes long term monitoring of environmental parameters, intensive field campaigns, use of satellite data and modelling studies. Therefore ChARMEx scientists produce and need to access a wide diversity of data. In this context, the objective of the database task is to organize data management, distribution system and services such as facilitating the exchange of information and stimulating the collaboration between researchers within the ChArMEx community, and beyond. The database relies on a strong collaboration between OMP and ICARE data centres and falls within the scope of the Mediterranean Integrated Studies at Regional And Locals Scales (MISTRALS) program data portal. All the data produced by or of interest for the ChArMEx community will be documented in the data catalogue and accessible through the database website: http://mistrals.sedoo.fr/ChArMEx. The database website offers different tools: - A registration procedure which enables any scientist to accept the data policy and apply for a user database account. - Forms to document observations or products that will be provided to the database in compliance with metadata international standards (ISO 19115-19139; INSPIRE; Global Change Master Directory Thesaurus). - A search tool to browse the catalogue using thematic, geographic and/or temporal criteria. - Sorted lists of the datasets by thematic keywords, by measured parameters, by instruments or by platform type. - A shopping-cart web interface to order in situ data files. At present datasets from the background monitoring station of Ersa, Cape Corsica and from the 2012 ChArMEx pre-campaign are available. - A user-friendly access to satellite products

  5. Spectroscopic analysis of visible and near UV light emitted by Ar7+ and Ar6+ ions produced in Ar8+-He and Ar8+-H2 collisions at 120 keV

    International Nuclear Information System (INIS)

    Boduch, P.; Chantepie, M.; Hennecart, D.; Husson, X.; Kucal, H.; Lecler, D.; Stolterfoht, N.; Druetta, M.; Fawcett, B.; Wilson, M.

    1992-01-01

    A spectroscopic analysis of light emitted in the 2000-6000A wavelength range by Ar 7+ and Ar 6+ ions produced in Ar 8+ -He and Ar 8+ -H 2 collisions at 120 keV is performed. Well resolved fine structure components of 5s-5p and 5p-5d transitions in Ar VIII following single electron capture are precisely measured. Predominant lines due to double electron capture are observed. In particular, strong lines observed both in Ar 8+ -He and Ar 8+ -H 2 collisions are attributed to Ryberg transitions 3snl-3sn'l' in Ar VII. Attempts at identifications are made for the transition 3dnl-3dn'l' (n=4, 5) with the help of ab initio calculations. Photon emission cross sections for individual lines are determined from the measured data. (orig.)

  6. Emergency preparedness with Ar-41 measurement

    International Nuclear Information System (INIS)

    Kunst, Juan J.; Rodriguez, Monica; Ugarte, Ricardo; Vigile, Sebastian; Boutet, Luis; Jordan, Osvaldo; Hernandez, Daniel

    2008-01-01

    Full text: The Nuclear Regulatory Authority (ARN) of Argentina is training their intervention group in the forecast of radiological consequences in case of a radiological or nuclear accident. In this context it has begun the measurement of Ar-41 near the research reactor RA3. It is well known the Ar-41 production inside research reactor, and it has been studied like a good mean to validate atmosphere dispersion model occurrence, or to develop method to improve the estimation of the characteristic of the emission. The measurements were made in two laboratories of ARN, Gamma measurement Laboratory, and CTC (Total Body Counter) Laboratory near the research reactor RA3. The emission of Ar-41 were determined by Measurements Group of Environmental Control Division inside the research reactor. The laboratories are at SE and ESE direction from the reactor. After the passage of a cold front, the wind flown from SE, in this situation and if the reactor is operating we could detect the presence of Ar-41 in the environment. This meteorological situation can be forecast by information submitted by National Meteorological Service of Argentina (SMN) in a meteograma. To correlate and evaluate the concentration in this laboratory, first it was determined the direction and persistence of wind in the site using the forecast of the National Meteorological Service (SMN) of Argentina to establish when the detectors were irradiated, during the radiological measurements, the real time wind direction an velocities measurement were did, with a site meteorological tower. With this information and cloudiness we determined de stability class and concentration. To determine concentration we used the code Hotspot and our code SEDA developed in ARN. In this paper are present the calibration of GeH detectors, and the location of them. We present several measurements did in this experience. We analyze the capacity developed by our teams to predict changes in wind direction and concentrations

  7. Can an arthroplasty risk score predict bundled care events after total joint arthroplasty?

    Directory of Open Access Journals (Sweden)

    Blair S. Ashley, MD

    2018-03-01

    Full Text Available Background: The validated Arthroplasty Risk Score (ARS predicts the need for postoperative triage to an intensive care setting. We hypothesized that the ARS may also predict hospital length of stay (LOS, discharge disposition, and episode-of-care cost (EOCC. Methods: We retrospectively reviewed a series of 704 patients undergoing primary total hip and knee arthroplasty over 17 months. Patient characteristics, 90-day EOCC, LOS, and readmission rates were compared before and after ARS implementation. Results: ARS implementation was associated with fewer patients going to a skilled nursing or rehabilitation facility after discharge (63% vs 74%, P = .002. There was no difference in LOS, EOCC, readmission rates, or complications. While the adoption of the ARS did not change the mean EOCC, ARS >3 was predictive of high EOCC outlier (odds ratio 2.65, 95% confidence interval 1.40-5.01, P = .003. Increased ARS correlated with increased EOCC (P = .003. Conclusions: Implementation of the ARS was associated with increased disposition to home. It was predictive of high EOCC and should be considered in risk adjustment variables in alternative payment models. Keywords: Bundled payments, Risk stratification, Arthroplasty

  8. K/Ar dating of diagenetic illites

    International Nuclear Information System (INIS)

    Mizusaki, A.M.P.; Anjos, S.M.C. dos; Costa, M.G.F. da; Silva, O.B. da; Kawashita, K.

    1990-01-01

    Ascertaining the potassium/argon (K/Ar) age of diagenetic illites yields important information for hydrocarbon exploration since the growth of this mineral in the pores of sandstone reservoir and oil migration are interlinked events in the diagenetic evolution of rocks. Illite growth ceases as soon as hydrocarbons completely fill in rock pores, displacing interstitial water. By providing an estimate of the period when the illite formed, K/Ar dating can indirectly tells us when hydrocarbons entered the reservoir. Samples of oil-saturated sandstones collected from Carboniferous reservoirs of the Solimoes Basin reveal a diagenetic evolution consisting predominantly of quartz, calcite, and illite overgrowths. In the present study, illite was mechanically separated by repeating a series of ultrasonic baths and ultrasonic probes followed by high-speed centrifuging. Resultant fractions were analyzed by X-ray diffractometry to measure the illite content of each sample. The separated illite material was found to be composed of illite and ordered mixed layer illite-smectite with 80% illite layers. Separated fractions were dated radiometrically by the K/Ar method. Preliminary results indicate an average age of some 200 m.y., which marks the end of the diagenetic development of the illites of this area. (author)

  9. Lifetime and spin measurements in 40Ar

    International Nuclear Information System (INIS)

    Southon, J.

    1976-01-01

    Lifetimes of levels in 40 Ar populated by the 40 Ar(p,p') reaction have been measured using the Doppler shift attenuation method with a p-γ coincidence technique. A solid argon target was used. The lifetimes determined were (in psec.): 1461 keV level, 1.95 +- 0.15; 2121 keV, >25; 2524 keV, 0.53 +- 0.06; 2893 keV, 4.4 [+2.6,-1.3]; 3208 keV, 0.27. A comprehensive set of branching ratios was also derived and the spins and parities of the 3208 and 4481 keV states were determined to be 2 + and 1 +- respectively. Some of these results suggest that 2 particle -2 hole and 4 particle - 4 hole components are strongly mixed in the low-lying positive parity states in a manner similar to the 2 particle and 4 particle - 2 hole mixing that occurs in 42 Ca. An additional lifetime measurement for the recently discovered high spin state at 3464 keV was carried out using direct electronic timing. The level was excited by the 37 Cl(α,p) reaction and was found to have a lifetime of 1.00 +- 0.03 nsec, which taken together with other evidence indicates that its spin and parity are 6 + . The E2 transition strengths of the 40 Ar 6 + - 4 + - 2 + - 0 + cascade can be simply interpreted in terms of a weak coupling model. (author)

  10. Timing and processes for exhumation of HP/LT rocks of the southern Brooks Range (AK): Insight from combined geochemistry and 40Ar/39Ar thermochronology of white mica

    Science.gov (United States)

    O'Brien, T.; Miller, E. L.; Grove, M. J.; Hayden, L. A.

    2015-12-01

    The obduction of an island arc onto the Arctic Alaska continental margin in the Jura-Cretaceous led to southward subduction of continental crust and high-pressure/low-temperature (HP/LT) epidote-blueschist facies metamorphism in the southern Brooks Range (BR). A regionally developed greenschist facies normal-sense shear zone system along the southern margin of the BR suggests that extensional faulting had an influential role in the exhumation of the metamorphic core. To better constrain the exhumation history of the metamorphic core of the BR, samples were collected from a N-S transect through the metamorphic core of the orogen. Electron microprobe (EMP) analyses of white micas reveal that they are composed of phengite (Si > 3.0 pfu) or a combination of phengite + paragonite. Si-content of phengites reveal a southward increase in Si from 3.1 to 3.4 pfu (corresponding to an increase in pressure). Si-contents in higher-P phengites are scattered, reflecting subsequent muscovite growth. The Si trend is matched by a southward increase in the 40Ar/39Ar total gas ages of white micas. Phengite from the north are characterized by younger ages (~115 Ma) and flatter 40Ar/39Ar spectra. Farther south, phengites and paragonites yield older 40Ar/39Ar ages. These samples yield convex, staircase 40Ar/39Ar spectra that initiate ~115-120 Ma and flatten-out ~130-138 Ma. Modeling using MacArgon proposes that an initial cooling of HP/LT metamorphism occurred ~130-138 Ma, recorded in the high-Si phengites and paragonites. Following initial cooling, modeling suggests HP/LT rocks stalled in the greenschist facies field before subsequent exhumation, resulting in the staircase 40Ar/39Ar spectra. Flatter 40Ar/39Ar spectra recorded by the northern samples and modeling of 40Ar/39Ar results from the southern samples suggest that these rocks from metamorphic core of the BR were exhumed to temperatures < 300°C by ~115 Ma.

  11. 40Ar/ 39Ar ages and paleomagnetism of São Miguel lavas, Azores

    Science.gov (United States)

    Johnson, Catherine L.; Wijbrans, Jan R.; Constable, Catherine G.; Gee, Jeff; Staudigel, Hubert; Tauxe, Lisa; Forjaz, Victor-H.; Salgueiro, Mário

    1998-08-01

    We present new 40Ar/ 39Ar ages and paleomagnetic data for São Miguel island, Azores. Paleomagnetic samples were obtained for 34 flows and one dike; successful mean paleomagnetic directions were obtained for 28 of these 35 sites. 40Ar/ 39Ar age determinations on 12 flows from the Nordeste complex were attempted successfully: ages obtained are between 0.78 Ma and 0.88 Ma, in contrast to published K-Ar ages of 1 Ma to 4 Ma. Our radiometric ages are consistent with the reverse polarity paleomagnetic field directions, and indicate that the entire exposed part of the Nordeste complex is of a late Matuyama age. The duration of volcanism across São Miguel is significantly less than previously believed, which has important implications for regional melt generation processes, and temporal sampling of the geomagnetic field. Observed stable isotope and trace element trends across the island can be explained, at least in part, by communication between different magma source regions at depth. The 40Ar/ 39Ar ages indicate that our normal polarity paleomagnetic data sample at least 0.1 Myr (0-0.1 Ma) and up to 0.78 Myr (0-0.78 Ma) of paleosecular variation and our reverse polarity data sample approximately 0.1 Myr (0.78-0.88 Ma) of paleosecular variation. Our results demonstrate that precise radiometric dating of numerous flows sampled is essential to accurate inferences of long-term geomagnetic field behavior. Negative inclination anomalies are observed for both the normal and reverse polarity time-averaged field. Within the data uncertainties, normal and reverse polarity field directions are antipodal, but the reverse polarity field shows a significant deviation from a geocentric axial dipole direction.

  12. 78 FR 41838 - Establishment of Class E Airspace; Colt, AR

    Science.gov (United States)

    2013-07-12

    ...-1281; Airspace Docket No. 12-ASW-13] Establishment of Class E Airspace; Colt, AR AGENCY: Federal... at Colt, AR. Controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard... Federal Register a notice of proposed rulemaking (NPRM) to establish Class E airspace for the Colt, AR...

  13. 75 FR 29657 - Establishment of Class E Airspace; Marianna, AR

    Science.gov (United States)

    2010-05-27

    ...-1167; Airspace Docket No. 09-ASW-33] Establishment of Class E Airspace; Marianna, AR AGENCY: Federal... for Marianna, AR to accommodate Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAPs) at Marianna/Lee County Airport--Steve Edwards Field, Marianna, AR. The FAA is taking this action to...

  14. 75 FR 68416 - Establishment of Class E Airspace; Berryville, AR

    Science.gov (United States)

    2010-11-08

    ...-0690; Airspace Docket No. 10-ASW-2] Establishment of Class E Airspace; Berryville, AR AGENCY: Federal... for Berryville, AR, to accommodate Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAP) at Carroll County Airport, Berryville, AR. The FAA is taking this action to enhance the safety...

  15. 75 FR 12161 - Establishment of Class E Airspace; Marianna, AR

    Science.gov (United States)

    2010-03-15

    ...-1167; Airspace Docket No. 09-ASW-33] Establishment of Class E Airspace; Marianna, AR AGENCY: Federal... proposes to establish Class E airspace at Marianna/Lee County Airport-Steve Edwards Field, Marianna, AR, to... operations at Marianna/Lee County Airport-Steve Edwards Field, Marianna, AR. Controlled airspace is needed...

  16. 75 FR 29656 - Amendment of Class E Airspace; Magnolia, AR

    Science.gov (United States)

    2010-05-27

    ...-1179; Airspace Docket No. 09-ASW-35] Amendment of Class E Airspace; Magnolia, AR AGENCY: Federal... airspace for Magnolia, AR. Decommissioning of the Magnolia non-directional beacon (NDB) at Magnolia Municipal Airport, Magnolia, AR has made this action necessary to enhance the safety and management of...

  17. 75 FR 12162 - Class E Airspace; Manila, AR

    Science.gov (United States)

    2010-03-15

    ...-1184; Airspace Docket No. 09-ASW-39] Class E Airspace; Manila, AR AGENCY: Federal Aviation... Class E airspace at Manila, AR. Decommissioning of the Manila non-directional beacon (NDB) at Manila... instrument approach procedures at Manila Municipal Airport, Manila, AR. Airspace reconfiguration is necessary...

  18. 76 FR 73505 - Establishment of Class E Airspace; Nashville, AR

    Science.gov (United States)

    2011-11-29

    ...-0497; Airspace Docket No. 11-ASW-4] Establishment of Class E Airspace; Nashville, AR AGENCY: Federal... for Nashville, AR, to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures... a notice of proposed rulemaking to amend Class E airspace for Nashville, AR, creating additional...

  19. 75 FR 29655 - Amendment of Class E Airspace; Batesville, AR

    Science.gov (United States)

    2010-05-27

    ...-1177; Airspace Docket No. 09-ASW-34] Amendment of Class E Airspace; Batesville, AR AGENCY: Federal... Batesville, AR. Decommissioning of the Independence County non-directional beacon (NDB) at Batesville Regional Airport, Batesville, AR, has made this action necessary to enhance the safety and management of...

  20. 75 FR 66300 - Amendment of Class E Airspace; Searcy, AR

    Science.gov (United States)

    2010-10-28

    ...-1182; Airspace Docket No. 09-ASW-37] Amendment of Class E Airspace; Searcy, AR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace for Searcy, AR. Decommissioning of the Searcy non-directional beacon (NDB) at Searcy Municipal Airport, Searcy, AR, has made this...

  1. 75 FR 37291 - Amendment of Class E Airspace; Osceola, AR

    Science.gov (United States)

    2010-06-29

    ...-1183; Airspace Docket No. 09-ASW-38] Amendment of Class E Airspace; Osceola, AR AGENCY: Federal... Osceola, AR. Decommissioning of the Osceola non-directional beacon (NDB) at Osceola Municipal Airport has... rulemaking to amend Class E airspace for Osceola, AR, reconfiguring controlled airspace at Osceola Municipal...

  2. 75 FR 12163 - Class E Airspace; Mountain View, AR

    Science.gov (United States)

    2010-03-15

    ...-1181; Airspace Docket No. 09-ASW-36] Class E Airspace; Mountain View, AR AGENCY: Federal Aviation... Class E airspace at Mountain View, AR. Decommissioning of the Wilcox non-directional beacon (NDB) at... View, AR. Airspace reconfiguration is necessary due to the decommissioning of the Wilcox NDB and the...

  3. 75 FR 29654 - Amendment of Class E Airspace; Manila, AR

    Science.gov (United States)

    2010-05-27

    ...-1184; Airspace Docket No. 09-ASW-39] Amendment of Class E Airspace; Manila, AR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace for Manila, AR. Decommissioning of the Manila non-directional beacon (NDB) at Manila Municipal Airport, Manila, AR has made this...

  4. 75 FR 12165 - Class E Airspace; Batesville, AR

    Science.gov (United States)

    2010-03-15

    ...-1177; Airspace Docket No. 09-ASW-34] Class E Airspace; Batesville, AR AGENCY: Federal Aviation... Class E airspace at Batesville, AR. Decommissioning of the Independence County non-directional beacon... for standard instrument approach procedures at Batesville Regional Airport, Batesville, AR. Airspace...

  5. Instant MuseScore

    CERN Document Server

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  6. Higher Education

    African Journals Online (AJOL)

    Kunle Amuwo: Higher Education Transformation: A Paradigm Shilt in South Africa? ... ty of such skills, especially at the middle management levels within the higher ... istics and virtues of differentiation and diversity. .... may be forced to close shop for lack of capacity to attract ..... necessarily lead to racial and gender equity,.

  7. 40Ar/39Ar and K-Ar age constraints on the timing of regional deformation, south coast of New South Wales, Lachlan Fold Belt: problems and implications

    International Nuclear Information System (INIS)

    Fergusson, C.L.; Phillips, D.

    2001-01-01

    Four slate samples from subduction complex rocks exposed on the south coast of New South Wales, south of Batemans Bay, were analysed by K-Ar and 40 Ar/ 39 Ar step-heating methods, One sample contains relatively abundant detrital muscovite flakes that are locally oblique to the regional cleavage in the rock, whereas the remaining samples appear to contain sparse detrital muscovite. Separates of detrital muscovite yielded plateau ages of 505 + 3 Ma and 513 + 3 Ma indicating that inheritance has not been eliminated by metamorphism and recrystallisation. Step-heating analyses of whole-rock chips from all four slate samples produced discordant apparent age spectra with 'saddle shapes' following young apparent ages at the lowest temperature increments. Elevated apparent ages associated with the highest temperature steps are attributed to the presence of variable quantities of detrital muscovite ( 40 Ar/ 39 Ar integrated ages of ca 455Ma, which are some 15-30 million years older than K-Ar ages for the same samples. These discrepancies suggest that the slates have also been affected by recoil loss/redistribution of 39 Ar, Ieading to anomalously old 40 Ar/ 39 Ar ages. Two other samples, from slaty tectonic melange and intensely cleaved slate, yielded average 40 Ar/ 39 Ar integrated ages of ca 424Ma, which are closer to associated mean K-Ar ages of 423 + 4Ma and 409 + 16Ma, respectively. Taking into account the potential influences of recoil loss/redistribution of 39 Ar and inheritance, the results from the latter samples suggest a maximum age of ca 440 Ma for deformation/metamorphism. The current results indicate that recoil and inheritance problems may also have affected whole-rock 40 Ar/ 39 Ar data reported from other regions of the Lachlan Fold Belt. Therefore, until these effects are adequately quantified, models for the evolution of the Lachlan Fold Belt, that are based on such whole-rock 40 Ar/ 39 Ar data, should be treated with caution. Copyright (2001) Geological

  8. Molecular dynamics study of Ar flow and He flow inside carbon nanotube junction as a molecular nozzle and diffuser

    Directory of Open Access Journals (Sweden)

    Itsuo Hanasaki, Akihiro Nakatani and Hiroshi Kitagawa

    2004-01-01

    Full Text Available A carbon nanotube junction consists of two connected nanotubes with different diameters. It has been extensively investigated as a molecular electronic device since carbon nanotubes can be metallic and semiconductive, depending on their structure. However, a carbon nanotube junction can also be viewed as a nanoscale nozzle andv diffuser. Here, we focus on the nanotube junction from the perspective of an intersection between machine, material and device. We have conducted a molecular dynamics simulation of the molecular flow inside a modeled (12,12–(8,8 nanotube junction. A strong gravitational field and a periodic boundary condition are applied in the flow direction. We investigated dense-Ar flows and dense-He flows while controlling the temperature of the nanotube junction. The results show that Ar atoms tend to be near to the wall and the density of the Ar is higher in the wide (12,12 nanotube than in the narrow (8,8 nanotube, while it is lower in the wide tube when no flow occurs. The streaming velocities of both the Ar and the He are higher in the narrow nanotube than in the wide nanotube, but the velocity of the Ar is higher than the velocity of the He and the temperature of the flowing Ar is higher than the temperature of the He when the same magnitude of gravitational field is applied.

  9. The thermal history of the Lhasa Block, South Tibetan Plateau based on FTD and Ar-Ar dating

    CERN Document Server

    Yang, T F; Lo Chong Huah; Chung, S L; Tien, R L; Xu, R; Deng, W

    1999-01-01

    Twelve basement samples were collected from South Tibet Plateau for FTD and Ar-Ar analysis to demonstrate their uplifting history since Cenozoic era. The preliminary results from different minerals with different closure temperatures, including apatite and zircon for fission-track dating, and K-feldspar, biotite for Ar-Ar dating, show that at least four stages of thermal history can be recognized in the studied area.

  10. Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells.

    Science.gov (United States)

    Fan, Lingling; Zhang, Fengbo; Xu, Songhui; Cui, Xiaolu; Hussain, Arif; Fazli, Ladan; Gleave, Martin; Dong, Xuesen; Qi, Jianfei

    2018-05-15

    Formation of the androgen receptor splicing variant 7 (AR-V7) is one of the major mechanisms by which resistance of prostate cancer to androgen deprivation therapy occurs. The histone demethylase JMJD1A (Jumonji domain containing 1A) functions as a key coactivator for AR by epigenetic regulation of H3K9 methylation marks. Here, we describe a role for JMJD1A in AR-V7 expression. While JMJD1A knockdown had no effect on full-length AR (AR-FL), it reduced AR-V7 levels in prostate cancer cells. Reexpression of AR-V7 in the JMJD1A-knockdown cells elevated expression of select AR targets and partially rescued prostate cancer cell growth in vitro and in vivo. The AR-V7 protein level correlated positively with JMJD1A in a subset of human prostate cancer specimens. Mechanistically, we found that JMJD1A promoted alternative splicing of AR-V7 through heterogeneous nuclear ribonucleoprotein F (HNRNPF), a splicing factor known to regulate exon inclusion. Knockdown of JMJD1A or HNRNPF inhibited splicing of AR-V7, but not AR-FL, in a minigene reporter assay. JMJD1A was found to interact with and promote the recruitment of HNRNPF to a cryptic exon 3b on AR pre-mRNA for the generation of AR-V7. Taken together, the role of JMJD1A in AR-FL coactivation and AR-V7 alternative splicing highlights JMJD1A as a potentially promising target for prostate cancer therapy.

  11. The thermal history of the Lhasa Block, South Tibetan Plateau based on FTD and Ar-Ar dating

    International Nuclear Information System (INIS)

    Yang, T.F.; Wang, J.R.; Lo, C.H.; Chung, S.L.; Tien, R.L.; Xu, R.; Deng, W.

    1999-01-01

    Twelve basement samples were collected from South Tibet Plateau for FTD and Ar-Ar analysis to demonstrate their uplifting history since Cenozoic era. The preliminary results from different minerals with different closure temperatures, including apatite and zircon for fission-track dating, and K-feldspar, biotite for Ar-Ar dating, show that at least four stages of thermal history can be recognized in the studied area

  12. Re-measurement of $^{32}$Ar to test the IMME

    CERN Multimedia

    The Isobaric Multiplet Mass Equation (IMME) has been subject to extensive studies in the low-mass region. Especially at the A = 32 quintet, the predicted quadratic form could not be confirmed, possible explanations being the insufficient accuracy of input parameters or higher-order interactions within the nucleon. For this quintet, the uncertainty on the mass-excess values of four of the five T = 2 multiplet members is extremely low: 0.6 keV for $^{32}$Cl, 0.3 keV for $^{32}$S, 0.2 keV for $^{32}$P, and 0.7 keV for $^{32}$Si. In the case of $^{32}$Ar, however, the uncertainty is as large as 1.8 keV. State-of-the-art high-precision Penning-trap mass spectrometry makes it possible to decrease this uncertainty. We propose to remeasure the mass of $^{32}$Ar at the Penning-trap mass spectrometer ISOLTRAP thus decreasing the uncertainty by a factor of 3-5. The proposed measurement is part of an experimental collaboration with JYFLTRAP, where the remaining masses of the T = 2 isospin quintet at A = 32 will be remeas...

  13. Call for Development of New Mineral Standards for 40Ar/39Ar Dating

    Science.gov (United States)

    Deino, A. L.; Turrin, B. D.; Renne, P. R.; Hemming, S. R.

    2015-12-01

    Age determination via the 40Ar/39Ar dating method relies on the intercomparison of measured 40Ar*/39ArK ratios of geological unknowns with those of co-irradiated mineral standards. Good analytical procedure dictates that these ratios (and the evolution of the Ar ion beams underpinning them) be as similar as practical for the greatest accuracy. Unfortunately, throughout several intervals of the geological time scale this 'best practice' cannot be achieved with existing widely used standards. Only two internationally utilized sanidine standards are available for the middle to late Cenozoic: the Alder Creek Rhyolite sanidine (ACs), at ~1.2 Ma (Turrin et al., 1994; Nomade et al., 2005), and the Fish Canyon Tuff sanidine (FCs) at ~28.2 Ma (e.g., Kuiper et al., 2008; Renne et al, 2011). The situation is even worse throughout much of the rest of the Phanerozoic, as the next oldest standard in common use is the Hb3gr hornblende standard with an age of ~1.1 Ga (Turner, 1971; Jourdan et al., 2006). We propose, as a community effort, the development a set of standards covering the entire target range of high-precision 40Ar/39Ar dating, i.e. the Phanerozoic. Their ages would be stepped in a regular fashion with no more than approximately a factor of 3 between standards, such that in the worse case the 40Ar*/39Ar ratios of standards and unknown need differ by no more than a factor of two. While somewhat arbitrary, an approximately 3 X age progression allows the entire time scale to be covered by a manageable number of standards. Anchoring the progression in the widely used ACs, FCs, and Hb3gr (in bold, below) yields the following set of suggested standard ages: 0.4, 1.2, 3.3, 9.4, 28.2, 95, 320, and 1100 Ma. A suitable standard should be highly reproducible in age at the grain-to-grain and sub-grain levels, and highly radiogenic. The mineral should be abundant and easily separated from the host rock. These criteria may be most easily achieved by focusing on sanidine phenocrysts

  14. The lod score method.

    Science.gov (United States)

    Rice, J P; Saccone, N L; Corbett, J

    2001-01-01

    The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential, so that pedigrees or lod curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders, where the maximum lod score (MLS) statistic shares some of the advantages of the traditional lod score approach but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the lod score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

  15. The Bayesian Score Statistic

    NARCIS (Netherlands)

    Kleibergen, F.R.; Kleijn, R.; Paap, R.

    2000-01-01

    We propose a novel Bayesian test under a (noninformative) Jeffreys'priorspecification. We check whether the fixed scalar value of the so-calledBayesian Score Statistic (BSS) under the null hypothesis is aplausiblerealization from its known and standardized distribution under thealternative. Unlike

  16. South African Scoring System

    African Journals Online (AJOL)

    2014-11-18

    Nov 18, 2014 ... for 80% (SASS score) and 75% (NOT) of the variation in the regression model. Consequently, SASS ... further investigation: spatial analyses of macroinvertebrate assemblages; and the use of structural and functional metrics. Keywords: .... conductivity levels was assessed using multiple linear regres- sion.

  17. Developing Scoring Algorithms

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  18. Application of quadrupole mass spectrometer to the 40Ar-39Ar geochronological study

    International Nuclear Information System (INIS)

    Takigami, Yutaka; Nishijima, Tadashi; Koike, Toshio; Okuma, Kouichi.

    1984-01-01

    A Quadrupole Mass Spectrometer (QMS) has commonly been used for qualitative analyses of gases in organic chemistry or for monitoring the vacuum conditions in industrial machines. No attempt has been made, however, to apply it to geochronological studies because of its disadvantages such as the difficulty in obtaining precise isotope ratios due to triangular peak shapes and poor reproducibility. On the other hand, there are advantages that a QMS is relatively inexpensive and gives a shorter scanning time for analysis compared with a sector type mass spectrometer. The latter characteristics is useful for 40 Ar/ 39 Ar geochronological studies, since it gives a lower background in the QMS and the possibility to obtain many more data from one sample in a limited time. In this study, we have tried to improve a commercial QMS at many parts, such as rf-generator, quadrupole, ionization chamber, source magnet, and so on, in order to meet the requirements to use it for geochronological studies. With the use of the improved QMS equipped with an on-line microcomputer, we could obtain Ar isotope data which are sufficiently precise for the 40 Ar/ 39 Ar geochronological studies. (author)

  19. A test of the 40Ar/39Ar age spectrum technique on some terrestrial materials

    Science.gov (United States)

    Lanphere, M.A.; Brent, Dalrymple G.

    1971-01-01

    40Ar/39Ar age spectra were determined for 10 terrestrial rock and mineral samples whose geologic history is known from independent evidence. The spectra for six mineral and whole rock samples, including biotite, feldspar, hornblende, muscovite, and granodiorite, that have experienced post-crystallization heating did not reveal the age of crystallization in any obvious way. Minima in the spectra, however, give reasonable maximum ages for reheating and high-temperature maxima can be interpreted as minimum crystallization ages. High-temperature ages of microcline and albite that have not been reheated are approximately 10% younger than the known crystallization age. Apparently there are no domains in these feldspars that have retained radiogenic 40Ar quantitatively. Spectra from two diabase samples that contain significant quantities of excess argon might mistakenly be interpreted as spectra from reheated samples and do not give the age of emplacement. The 40Ar/39Ar age spectrum technique may be a potentially valuable tool for the study of geologic areas with complex histories, but the interpretation of age spectra from terrestrial samples seems to be more difficult than suggested by some previous studies. ?? 1971.

  20. The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

    Science.gov (United States)

    Abdulrahman, Basant A; Abdelaziz, Dalia; Thapa, Simrika; Lu, Li; Jain, Shubha; Gilch, Sabine; Proniuk, Stefan; Zukiwski, Alexander; Schatzl, Hermann M

    2017-12-14

    Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP C ) into the pathologic isoform PrP Sc is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that demonstrated preclinical activity against several microbial diseases. Recently, AR-12 has been shown to facilitate clearance of misfolded proteins. The latter proposes AR-12 to be a potential therapeutic agent for neurodegenerative disorders. In this study, we investigated the role of AR-12 and its derivatives in controlling prion infection. We tested AR-12 in prion infected neuronal and non-neuronal cell lines. Immunoblotting and confocal microscopy results showed that AR-12 and its analogue AR-14 reduced PrP Sc levels after only 72 hours of treatment. Furthermore, infected cells were cured of PrP Sc after exposure of AR-12 or AR-14 for only two weeks. We partially attribute the influence of the AR compounds on prion propagation to autophagy stimulation, in line with our previous findings that drug-induced stimulation of autophagy has anti-prion effects in vitro and in vivo. Taken together, this study demonstrates that AR-12 and the AR-14 analogue are potential new therapeutic agents for prion diseases and possibly protein misfolding disorders involving prion-like mechanisms.

  1. Legacy K/Ar and 40Ar/39Ar geochronologic data from the Alaska-Aleutian Range batholith of south-central Alaska

    Science.gov (United States)

    Koeneman, Lisa L.; Wilson, Frederic H.

    2018-04-06

    Sample descriptions and analytical data for more than 200 K/Ar and 40Ar/39Ar analyses from rocks of the Alaska-Aleutian Range batholith of south-central Alaska are reported here. Samples were collected over a period of 20 years by Bruce R. Reed and Marvin A. Lanphere (both U.S. Geological Survey) as part of their studies of the batholith.

  2. Timing of Hydrocarbon Fluid Emplacement in Sandstone Reservoirs in Neogene in Huizhou Sag, Southern China Sea, by Authigenic Illite 40Ar- 39Ar Laser Stepwise Heating

    Science.gov (United States)

    Hesheng, Shi; Junzhang, Zhu; Huaning, Qiu; yu, Shu; Jianyao, Wu; Zulie, Long

    Timing of oil or gas emplacements is a new subject in isotopic geochronology and petroleum geology. Hamilton et al. expounded the principle of the illite K-Ar age: Illite is often the last or one of the latest mineral cements to form prior to hydrocarbon accumulation. Since the displacement of formation water by hydrocarbons will cause silicate diagenesis to cease, K-Ar ages for illite will constrain the timing of this event, and also constrain the maximum age of formation of the trap structure. In this study, the possibility of authigenic illites 40Ar- 39Ar dating has been investigated. The illite samples were separated from the Tertiary sandstones in three rich oil reservoir belts within the Huizhou sag by cleaning, fracturing by cycled cooling-heating, soxhlet-extraction with solvents of benzene and methanol and separating with centrifugal machine. If oil is present in the separated samples, ionized organic fragments with m/e ratios of 36 to 40 covering the argon isotopes will be yielded by the ion source of a mass spectrometer, resulting in wrong argon isotopic analyses and wrong 40Ar- 39Ar ages. The preliminary experiments of illite by heating did show the presence of ionized organic fragments with m/e ratios of 36 to 44. In order to clean up the organic gases completely and obtain reliable analysis results, a special purification apparatus has been established by Qiu et al. and proved valid by the sequent illite analyses. All the illite samples by 40Ar- 39Ar IR-laser stepwise heating yield stair-up age spectra in lower laser steps and plateaux in higher laser steps. The youngest apparent ages corresponding to the beginning steps are reasonable to be interpreted for the hydrocarbon accumulation ages. The weighted mean ages of the illites from the Zhuhai and Zhujiang Formations are (12.1 ± 1.1) Ma and (9.9 ± 1.2) Ma, respectively. Therefore, the critical emplacement of petroleum accumulation in Zhujiang Formation in Huizhou sag took place in ca 10 Ma. Late

  3. Higher Education

    Science.gov (United States)

    & Development (LDRD) National Security Education Center (NSEC) Office of Science Programs Richard P Databases National Security Education Center (NSEC) Center for Nonlinear Studies Engineering Institute Scholarships STEM Education Programs Teachers (K-12) Students (K-12) Higher Education Regional Education

  4. MEIS1 functions as a potential AR negative regulator

    International Nuclear Information System (INIS)

    Cui, Liang; Li, Mingyang; Feng, Fan; Yang, Yutao; Hang, Xingyi; Cui, Jiajun; Gao, Jiangping

    2014-01-01

    The androgen receptor (AR) plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. In this study, we investigated a potential interaction between MEIS1 and AR. We found that overexpression of MEIS1 inhibited the AR transcriptional activity and reduced the expression of AR target gene. A potential protein–protein interaction between AR and MEIS1 was identified by the immunoprecipitation and GST pull-down assays. Furthermore, MEIS1 modulated AR cytoplasm/nucleus translocation and the recruitment to androgen response element in prostate specific antigen (PSA) gene promoter sequences. In addition, MEIS1 promoted the recruitment of NCoR and SMRT in the presence of R1881. Finally, MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells. Taken together, our data suggests that MEIS1 functions as a novel AR co-repressor. - Highlights: • A potential interaction was identified between MEIS1 and AR signaling. • Overexpression of MEIS1 reduced the expression of AR target gene. • MEIS1 modulated AR cytoplasm/nucleus translocation. • MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells

  5. Quantum treatment of the Ar-HI photodissociation dynamics

    International Nuclear Information System (INIS)

    Lopez-Lopez, Sergio; Prosmiti, Rita; Garcia-Vela, Alberto

    2004-01-01

    A wave packet simulation of the ultraviolet photolysis dynamics of Ar-HI(v=0) is reported. Cluster photodissociation is started from two different initial states, namely, the ground van der Waals (vdW) and the first excited vdW bending state, associated with the Ar-I-H and Ar-H-I isomeric forms of the system, respectively. Formation of Ar-I radical products is investigated over the energy range of the cluster absorption spectrum. It is found that the yield of bound Ar-I radical complexes is typically 90%-100% and 70%-80% for the initial states associated with the Ar-I-H and Ar-H-I isomers, respectively. This result is in agreement with the experimentally observed time-of-flight spectrum of the hydrogen fragment produced after Ar-HI photodissociation. The high Ar-I yield is explained mainly by the small amount of energy available for the radical that is converted into internal energy in the photofragmentation process, which enhances the Ar-I survival probability. Quantum interference effects manifest themselves in structures in the angular distribution of the hydrogen fragment, and in pronounced rainbow patterns in the rotational distributions of the Ar-I radical

  6. Argon defect complexes in low energy Ar irradiated molybdenum

    International Nuclear Information System (INIS)

    Veen, A. van; Buters, W.T.M.; Kolk, G.J. van der; Caspers, L.M.; Armstrong, T.R.

    1982-01-01

    Thermal desorption spectrometry has been used to study the defects created in Mo irradiated along the direction with Ar ions ranging in energy from 0.1 to 2 keV. In addition to monitoring the release of the implanted Ar, additional information has been obtained by decoration of the defects with low energy helium and subsequent monitoring of the helium release. The studies show evidence that the Ar can be trapped in both substitutional sites and in a configuration in which the Ar is associated with vacancies (ArVsub(n), n >= 2). Most of the Ar implanted at high energy is released at approx. equal to 1500 K by thermal vacancy assisted diffusion. Argon trapped closer to the surface is released at lower temperatures via at least three different surface related release mechanisms. Additional results are presented on the interaction of self interstitial atoms (introduced by 100 eV Xe bombardment) with the Ar defects. Substitutional Ar is found to convert to interstitial Ar which seems to be mobile at room temperature. The Ar-vacancy complexes are found to be reduced to substitutional Ar. The results of atomistic calculations of the release mechanisms will also be presented. (orig.)

  7. Near thermal charge transfer between Ar+2 and N2

    International Nuclear Information System (INIS)

    Holzscheiter, H.M.; Church, D.A.

    1981-01-01

    The near thermal charge transfer reaction of Ar +2 with N 2 has been studied at total pressures below 10 -7 Torr using a stored ion technique. Ar +2 ions produced by electron impact double ionization of Ar gas were selectively stored for times the order of seconds in a split-ring Penning-type ion trap. The decay with time of the initial ion sample number in a mixture of Ar and N 2 gases was fit to the sum of two exponentials, corresponding to different reaction rates for the 3 P and 1 D low-lying Ar +2 levels. The observed Ar +2 number decrease is attributed to the double-charge transfer process Ar +2 +N 2 →Ar+N 2 +2 →Ar+N + +N + in accord with recent flow-tube measurements. A rate constant for the metastable Ar +2 ( 1 D) level reaction with a value k( 1 D)=1.4 x 10 -9 cm 3 /sec is obtained, using the previously measured rate constant for the Ar +2 ( 3 P) state

  8. MEIS1 functions as a potential AR negative regulator

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Liang [Department of Urology, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China); Department of Urology, Civil Aviation General Hospital/Civil Aviation Medical College of Peking University, Beijing 100123 (China); Li, Mingyang [Department of Gastroenterology, Nan Lou Division, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China); Feng, Fan [Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016 (China); Yang, Yutao [Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069 (China); Hang, Xingyi [National Scientific Data Sharing Platform for Population and Health, Beijing 100730 (China); Cui, Jiajun, E-mail: cuijn@ucmail.uc.edu [Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 (United States); Gao, Jiangping, E-mail: jpgao@163.com [Department of Urology, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China)

    2014-10-15

    The androgen receptor (AR) plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. In this study, we investigated a potential interaction between MEIS1 and AR. We found that overexpression of MEIS1 inhibited the AR transcriptional activity and reduced the expression of AR target gene. A potential protein–protein interaction between AR and MEIS1 was identified by the immunoprecipitation and GST pull-down assays. Furthermore, MEIS1 modulated AR cytoplasm/nucleus translocation and the recruitment to androgen response element in prostate specific antigen (PSA) gene promoter sequences. In addition, MEIS1 promoted the recruitment of NCoR and SMRT in the presence of R1881. Finally, MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells. Taken together, our data suggests that MEIS1 functions as a novel AR co-repressor. - Highlights: • A potential interaction was identified between MEIS1 and AR signaling. • Overexpression of MEIS1 reduced the expression of AR target gene. • MEIS1 modulated AR cytoplasm/nucleus translocation. • MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells.

  9. The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR).

    Science.gov (United States)

    Xiong, Yaoyao; Wang, Long; Li, Yuan; Chen, Minfeng; He, Wei; Qi, Lin

    2017-01-01

    Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA's target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells' proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3'UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation. © 2017 The Author(s). Published by S. Karger AG, Basel.

  10. The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR

    Directory of Open Access Journals (Sweden)

    Yaoyao Xiong

    2017-08-01

    Full Text Available Backgrounds/Aims: Long non-coding RNA (lncRNA X-inactive specific transcript (XIST is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. Results: XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells’ proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3’UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. Conclusion: These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation.

  11. AR-Signaling in Human Malignancies: Prostate Cancer and Beyond

    Directory of Open Access Journals (Sweden)

    Michael T. Schweizer

    2017-01-01

    Full Text Available In the 1940s Charles Huggins reported remarkable palliative benefits following surgical castration in men with advanced prostate cancer, and since then the androgen receptor (AR has remained the main therapeutic target in this disease. Over the past couple of decades, our understanding of AR-signaling biology has dramatically improved, and it has become apparent that the AR can modulate a number of other well-described oncogenic signaling pathways. Not surprisingly, mounting preclinical and epidemiologic data now supports a role for AR-signaling in promoting the growth and progression of several cancers other than prostate, and early phase clinical trials have documented preliminary signs of efficacy when AR-signaling inhibitors are used in several of these malignancies. In this article, we provide an overview of the evidence supporting the use of AR-directed therapies in prostate as well as other cancers, with an emphasis on the rationale for targeting AR-signaling across tumor types.

  12. Dissociative recombination of rare gas hydride ions: II. ArH+

    International Nuclear Information System (INIS)

    Mitchell, J B A; Novotny, O; LeGarrec, J L; Florescu-Mitchell, A; Rebrion-Rowe, C; Stolyarov, A V; Child, M S; Svendsen, A; Ghazaly, M A El; Andersen, L H

    2005-01-01

    A storage ring measurement of the rate coefficient for the production of neutral Ar in e + ArH + collisions is described. It is found that the recombination rate is too small to measure at low centre-of-mass energies but the combined rate coefficient for dissociative recombination and dissociative excitation increases above 2.5 eV displaying peaks centred at 7.5 eV, 16 and 26 eV. Calculated potential energy curves for the ground and excited states of ArH + are presented and these aid in the elucidation of the recombination and excitation processes observed at higher energies. The implications for plasma modelling are discussed. (letter to the editor)

  13. The ChArMEx database

    Science.gov (United States)

    Ferré, Helene; Belmahfoud, Nizar; Boichard, Jean-Luc; Brissebrat, Guillaume; Descloitres, Jacques; Fleury, Laurence; Focsa, Loredana; Henriot, Nicolas; Mastrorillo, Laurence; Mière, Arnaud; Vermeulen, Anne

    2014-05-01

    The Chemistry-Aerosol Mediterranean Experiment (ChArMEx, http://charmex.lsce.ipsl.fr/) aims at a scientific assessment of the present and future state of the atmospheric environment in the Mediterranean Basin, and of its impacts on the regional climate, air quality, and marine biogeochemistry. The project includes long term monitoring of environmental parameters, intensive field campaigns, use of satellite data and modelling studies. Therefore ChARMEx scientists produce and need to access a wide diversity of data. In this context, the objective of the database task is to organize data management, distribution system and services, such as facilitating the exchange of information and stimulating the collaboration between researchers within the ChArMEx community, and beyond. The database relies on a strong collaboration between OMP and ICARE data centres and has been set up in the framework of the Mediterranean Integrated Studies at Regional And Locals Scales (MISTRALS) program data portal. All the data produced by or of interest for the ChArMEx community will be documented in the data catalogue and accessible through the database website: http://mistrals.sedoo.fr/ChArMEx. At present, the ChArMEx database contains about 75 datasets, including 50 in situ datasets (2012 and 2013 campaigns, Ersa background monitoring station), 25 model outputs (dust model intercomparison, MEDCORDEX scenarios), and a high resolution emission inventory over the Mediterranean. Many in situ datasets have been inserted in a relational database, in order to enable more accurate data selection and download of different datasets in a shared format. The database website offers different tools: - A registration procedure which enables any scientist to accept the data policy and apply for a user database account. - A data catalogue that complies with metadata international standards (ISO 19115-19139; INSPIRE European Directive; Global Change Master Directory Thesaurus). - Metadata forms to document

  14. 40Ar-39Ar laser probe dating of individual clinopyroxene inclusions in Premier eclogitic diamonds

    International Nuclear Information System (INIS)

    Burgess, R.; Turner, G.; Laurenzi, M.; Harris, J.W.

    1989-01-01

    The ages of seven individual clinopyroxene inclusions in Premier diamonds of eclogitic association have been determined using the 40 Ar- 39 Ar dating technique. Syngenetic inclusions weighing between 10 and 130 μg were exposed on cleaved surfaces of the diamonds and analysed using a laser probe. The inclusion ages were found to be in the range 1111±35 to 1254±38 Ma with an average of 1185±94 Ma. The ages obtained are in good agreement with previous determinations made on aggregates of eclogitic inclusions from Premier diamonds and demonstrate the applicability of the laser probe to dating individual diamond inclusions. (orig.)

  15. Argon in hornblende, biotite and muscovite in geologic cooling - Ar-40/Ar-39-investigations

    International Nuclear Information System (INIS)

    Rittman, K.L.

    1984-01-01

    The results of the Ar-40/Ar-39 studies are discussed under the aspect of whether the age data of the minerals indicate a cooling process. The author hopes that isotope dating of minerals with different closing temperatures will describe the temperature/time history of an area in the temperature range of 600 to 200 0 C. The findings are analyzed under three aspects: How much do they contribute to the initial methodological question, what do they contribute to the regional geology of the areas investigated, and in what respects do they extent the present knowledge of the geochronological analysis, i.e. its techniques and interpretation. (orig.) [de

  16. Microbiologia do ar : monitorização do ar em ambiente hospitalar

    OpenAIRE

    Santos, Ana Carina Marques dos

    2008-01-01

    O complexo ambiente hospitalar requer atenção especial, para assegurar uma saudável qualidade do ar interior, protegendo assim os profissionais de saúde e utentes de infecções nosocomiais e de doenças ocupacionais. Embora seja amplamente reconhecido que a contaminação de um bloco operatório seja a principal responsável pela complicação de uma cirurgia, em Portugal, estudos sobre microbiologia do ar a nível hospitalar são escassos. O objectivo deste estudo é investigar a vari...

  17. Credit scoring methods

    Czech Academy of Sciences Publication Activity Database

    Vojtek, Martin; Kočenda, Evžen

    2006-01-01

    Roč. 56, 3-4 (2006), s. 152-167 ISSN 0015-1920 R&D Projects: GA ČR GA402/05/0931 Institutional research plan: CEZ:AV0Z70850503 Keywords : banking sector * credit scoring * discrimination analysis Subject RIV: AH - Economics Impact factor: 0.190, year: 2006 http://journal.fsv.cuni.cz/storage/1050_s_152_167.pdf

  18. Age intercalibration of 40Ar/39Ar sanidine and chemically distinct U/Pb zircon populations from the Alder Creek Rhyolite Quaternary geochronology standard

    DEFF Research Database (Denmark)

    Rivera, Tiffany; Storey, Michael; Schmitz, M. D.

    2013-01-01

    , and have less pronounced positive Ce and negative Eu anomalies, lower incompatible trace element contents, higher TiZR temperatures that range up to 840 °C, and significantly younger dates. The youngest Group A dates yield a weighted mean of 1.1978 ± 0.0046 Ma (2σ, including systematic uncertainties...... with the astronomical age estimate for the Cobb Mountain subchron determined by correlating the oxygen isotope record of the giant piston core MD972143 to the La93(1,1) orbital solution. On the basis of independent radio-isotopic and orbital forcing results, we propose the refined age of 1.1850 ± 0.0016 Ma (2σ external......We report results from a 40Ar/39Ar sanidine and CA-TIMS 238U/206Pb zircon dating study of eruption and crystal residence timescales of the Alder Creek Rhyolite (ACR), California, extruded during the Cobb Mountain normal-polarity subchron (C1r.2n). A 40Ar/39Ar ACR sanidine date of 1.1850 ± 0.0016 Ma...

  19. H + Ar collisions. II. Differential scattering calculations

    International Nuclear Information System (INIS)

    Neumann, H.; Le, T.Q.; van Zyl, B.

    1977-01-01

    Differential elastic scattering cross-section calculations have been made for H + Ar collisions using classical and eikonal techniques. The calculation procedures are described and compared with existing experimental data. It is shown that the angular distribution of the elastic cross section is similar to that obtained for proton production in such collisions at energies above about 200 eV. By combining the angular dependence of the computed elastic cross section with experimental measurements described in the preceding paper, absolute differential cross sections for proton production have been determined

  20. Credit scoring for individuals

    Directory of Open Access Journals (Sweden)

    Maria DIMITRIU

    2010-12-01

    Full Text Available Lending money to different borrowers is profitable, but risky. The profits come from the interest rate and the fees earned on the loans. Banks do not want to make loans to borrowers who cannot repay them. Even if the banks do not intend to make bad loans, over time, some of them can become bad. For instance, as a result of the recent financial crisis, the capability of many borrowers to repay their loans were affected, many of them being on default. That’s why is important for the bank to monitor the loans. The purpose of this paper is to focus on credit scoring main issues. As a consequence of this, we presented in this paper the scoring model of an important Romanian Bank. Based on this credit scoring model and taking into account the last lending requirements of the National Bank of Romania, we developed an assessment tool, in Excel, for retail loans which is presented in the case study.

  1. Effect of protected research time on ABSITE scores during general surgery residency.

    Science.gov (United States)

    Orkin, Bruce A; Poirier, Jennifer; Kowal-Vern, Areta; Chan, Edie; Ohara, Karen; Mendoza, Brian

    2018-02-01

    Objective - To determine whether residents with one or more years of dedicated research time (Research Residents, RR) improved their ABSITE scores compared to those without (Non-Research Residents, N-RR). A retrospective review of general surgery residents' ABSITE scores from 1995 to 2016 was performed. RR were compared to N-RR. Additional analysis of At Risk (AR) v Not At Risk residents (NAR) (35th percentile as PGY1-2) was also performed. Cohort - 147 residents (34 RR and 113 N-RR). There were no differences in initial ABSITE scores (p = 0.47). By definition, the AR group had lower scores than NAR. Overall, post-research RR v PGY-4 N-RR scores did not differ (p = 0.84). Only the AR residents improved their scores (p = 0.0009 v NAR p = 0.42), regardless of research group (p = 0.70). Protected research time did not improve residents' ABSITE scores, regardless of initial scores. At Risk residents improved regardless of research group status. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells.

    Science.gov (United States)

    Olson, Brian M; Gamat, Melissa; Seliski, Joseph; Sawicki, Thomas; Jeffery, Justin; Ellis, Leigh; Drake, Charles G; Weichert, Jamey; McNeel, Douglas G

    2017-12-01

    Androgen deprivation is the primary therapy for recurrent prostate cancer, and agents targeting the androgen receptor (AR) pathway continue to be developed. Because androgen-deprivation therapy (ADT) has immmunostimulatory effects as well as direct antitumor effects, AR-targeted therapies have been combined with other anticancer therapies, including immunotherapies. Here, we sought to study whether an antigen-specific mechanism of resistance to ADT (overexpression of the AR) may result in enhanced AR-specific T-cell immune recognition, and whether this might be strategically combined with an antitumor vaccine targeting the AR. Androgen deprivation increased AR expression in human and murine prostate tumor cells in vitro and in vivo The increased expression persisted over time. Increased AR expression was associated with recognition and cytolytic activity by AR-specific T cells. Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). Together, these data suggest that ADT combined with AR-directed immunotherapy targets a major mechanism of resistance, overexpression of the AR. This combination may be more effective than ADT combined with other immunotherapeutic approaches. Cancer Immunol Res; 5(12); 1074-85. ©2017 AACR . ©2017 American Association for Cancer Research.

  3. Neutral bremsstrahlung radiation of Ne, Ar and O

    International Nuclear Information System (INIS)

    Kung, R.T.V.; Chang, C.H.

    1976-01-01

    The neutral Bremsstrahlung cross-sections of Ne, Ar and atomic oxygen around the 3 and 10μ wavelength regions were measured in a high temperature plasma generated in a shock tube. The results were generally a factor of three higher than the theoretical values calculated by Geltman (Geltman, S., JQSRT vol.13, 601 (1973)). Agreement with the experimental results of Taylor and Caledonia (Taylor, R.L. and Caledonia, G., JQSRT vol.9, 657; 681, 1969) around 3μ was good except for the case of Ne. The cross-sections around 10μ are the first measurements in this wavelength region. Enhanced radiation due to atomic line emission on top of the Bremsstrahlung continuum, as predicted by Hyman (Hyman, H.A. and Von Rosenberg, C.W. Jr., JQSRT, vol.15, 919, 1975) was observed around 7.44μ. (author)

  4. Development, validation and psychometric properties of the Arabic version of the Orofacial Esthetic Scale: OES-Ar.

    Science.gov (United States)

    Alhajj, Mohammed Nasser; Amran, Abdullah Ghalib; Halboub, Esam; Al-Basmi, Abdulghani Ali; Al-Ghabri, Fawaz Abdullah

    2017-07-01

    This study aimed at developing the Arabic version of the Orofacial Esthetic Scale (OES-Ar) and to investigate its psychometric properties among Arabic-speaking population with and without esthetic impairments. Translation and cross-cultural adaptation was done according to the standard guidelines. Internal consistency was assessed on 230 participants. For test-retest reliability, 50 subjects with natural teeth were recalled within a period of 2 weeks. Validity of the OES-Ar was tested by construct, convergent, and discriminant validity tests. Responsiveness to esthetic changes was assessed in 60 patients. The results showed excellent internal consistency with Cronbach's alpha value of 0.92 and inter-item correlation average value of 0.60. The ICC values ranged from 0.87 to 0.96 which indicated excellent agreement. Construct validity of the OES-Ar was confirmed to be one-factor structure (one-dimensional). For convergent validity, a significant correlation was found between OES summary score and overall impression of the orofacial esthetic as well as between OES summary score and the summary score of the three questions of the OHIP-49Ar related to esthetic. The discriminant validity test revealed significant differences between different study groups (Pesthetics in Arabic-speaking patients. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  5. Higher Education.

    Science.gov (United States)

    Hendrickson, Robert M.

    This chapter reports 1982 cases involving aspects of higher education. Interesting cases noted dealt with the federal government's authority to regulate state employees' retirement and raised the questions of whether Title IX covers employment, whether financial aid makes a college a program under Title IX, and whether sex segregated mortality…

  6. Preparation of water and ice samples for 39Ar dating by atom trap trace analysis (ATTA)

    Science.gov (United States)

    Schwefel, R.; Reichel, T.; Aeschbach-Hertig, W.; Wagenbach, D.

    2012-04-01

    Atom trap trace analysis (ATTA) is a new and promising method to measure very rare noble gas radioisotopes in the environment. The applicability of this method for the dating of very old groundwater with 81Kr has already been demonstrated [1]. Recent developments now show its feasibility also for the analysis of 39Ar [2,3], which is an ideal dating tracer for the age range between 50 and 1000 years. This range is of interest in the fields of hydro(geo)logy, oceanography, and glaciology. We present preparation (gas extraction and Ar separation) methods for groundwater and ice samples for later analysis by the ATTA technique. For groundwater, the sample size is less of a limitation than for applications in oceanography or glaciology. Large samples are furthermore needed to enable a comparison with the classical method of 39Ar detection by low-level counting. Therefore, a system was built that enables gas extraction from several thousand liters of water using membrane contactors. This system provides degassing efficiencies greater than 80 % and has successfully been tested in the field. Gas samples are further processed to separate a pure Ar fraction by a gas-chromatographic method based on Li-LSX zeolite as selective adsorber material at very low temperatures. The gas separation achieved by this system is controlled by a quadrupole mass spectrometer. It has successfully been tested and used on real samples. The separation efficiency was found to be strongly temperature dependent in the range of -118 to -130 °C. Since ATTA should enable the analysis of 39Ar on samples of less than 1 ccSTP of Ar (corresponding to about 100 ml of air, 2.5 l of water or 1 kg of ice), a method to separate Ar from small amounts of gas was developed. Titanium sponge was found to absorb 60 ccSTP of reactive gases per g of the getter material with reasonably high absorption rates at high operating temperatures (~ 800 ° C). Good separation (higher than 92 % Ar content in residual gas) was

  7. StAR protein and steroidogenic enzyme expressions in the rat Harderian gland.

    Science.gov (United States)

    Falvo, Sara; Chieffi Baccaria, Gabriella; Spaziano, Giuseppe; Rosati, Luigi; Venditti, Massimo; Di Fiore, Maria Maddalena; Santillo, Alessandra

    2018-03-01

    The Harderian gland (HG) of the rat (Rattus norvegicus) secretes copious amounts of lipids, such as cholesterol. Here we report a study of the expressions of the StAR protein and key steroidogenic enzymes in the HG of male and female rats. The objective of the present investigation was to ascertain (a) whether the rat HG is involved in steroid production starting with cholesterol, and (b) whether the pattern of gene and protein expressions together with the enzymatic activities display sexual dimorphism. The results demonstrate, for the first time, the expression of StAR gene and protein, and Cyp11a1, Hsd3b1, Hsd17b3, Srd5a1, Srd5a2 and Cyp19a1 genes in the rat HG. StAR mRNA and protein expressions were much greater in males than in females. Immunohistochemical analysis demonstrated a non-homogeneous StAR distribution among glandular cells. Hsd17b3 and Cyp19a1 mRNA levels were higher in males than in females, whereas Srd5a1 mRNA levels were higher in females than in males. No significant differences were observed in mRNA levels of Cyp11a1, Hsd3b1 and Srd5a2 between sexes. Furthermore, the in vitro experiments demonstrated a higher 5α-reductase activity in the female as compared to the male HG vice versa a higher P450 aro activity in males as compared to females. These results suggest that the Harderian gland can be classified as a steroidogenic tissue because it synthesizes cholesterol, expresses StAR and steroidogenic enzymes involved in both androgen and estrogen synthesis. The dimorphic expression and activity of the steroidogenic enzymes may suggest sex-specific hormonal effects into the HG physiology. Copyright © 2018 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.

  8. Light Curve Variations of AR Lacertae

    Directory of Open Access Journals (Sweden)

    Il-Seong Nha

    1991-12-01

    Full Text Available Sixteen unitary Light curves of AR Lac in B and V are made at Yonsei University Observatory in the period of 1980-1988. Some overview findings of light variations are made. (1 The light variations outside eclipse follow none of the wave migration patterns reported by previous investigators. (2 Complicated shapes outside eclipse are apparently much reduced in the light curves of 1983-1984. This suggests that, in the future, AR Lac has a chance to attain a normal state with mo complicated interactions. (3 The depths of the primary and the secondary mid-eclipses are changing year-to-year. (4 The K0 star, the larger component, has brightened by 0.m14 V, while the G2 star has shown a fluctuation of about 0.m05 in V. (5 The B-V values at primary mid-eclipse have no correlation with the depth variations. (6 Independently of the increase of maximum brightness, the B-V colors in the non-eclipsed phases changed slightly over the years.

  9. College Math Assessment: SAT Scores vs. College Math Placement Scores

    Science.gov (United States)

    Foley-Peres, Kathleen; Poirier, Dawn

    2008-01-01

    Many colleges and university's use SAT math scores or math placement tests to place students in the appropriate math course. This study compares the use of math placement scores and SAT scores for 188 freshman students. The student's grades and faculty observations were analyzed to determine if the SAT scores and/or college math assessment scores…

  10. High-resolution 40Ar/39Ar chronology of multiple intrusion igneous complexes

    Science.gov (United States)

    Foland, K. A.; Chen, J.-F.; Linder, J. S.; Henderson, C. M. B.; Whillans, I. M.

    1989-06-01

    The Mount Brome complex of the Monteregian province of southern Quebec, Canada, consits of several major intrusions ranging compositionally from gabbro to syenite. The relative ages of these intrusives have been investigated with high-resolution 40Ar/39Ar analyses, including a specially designed irradiation configuration to cancel the effects of fluence gradients. Small yet distinct apparent age differences are observed. While a number of analytical and geological factors could be proposed to explain the small variations, evaluation of these suggests the age differences reflect those in emplacement times. The gabbro and nepheline diorite were emplaced within a short span 123.1 Ma ago. Generally more evolved lithologies (biotite monzodiorite, pulaskite, nordmarkite) appear to have been emplaced within a restricted interval 1.4±0.3 Ma later. Whole-rock Rb-Sr systematics do not give acceptable isochrons because of significant scatter interpreted to reflect initial 87Sr/86Sr heterogeneities resulting from crustal contamination. Considering the variations in initial ratio, the Rb-Sr data are consistent with the 40Ar/39Ar age.

  11. 40Ar-39Ar dating of hornfels dredged near the Japan trench

    International Nuclear Information System (INIS)

    Takigami, Yutaka; Fujioka, Kantaro

    1989-01-01

    During the KH 81-3 Cruise of the R/V Hakuho-Maru, biotite-bearing hornfelses were dredged from the landward slope of the Japan Trench. Bulk sample and separated biotite were dated by the 40 Ar- 39 Ar method and they showed 40 Ar- 39 Ar ages of 28.9±1.4 Ma and 28.5±1.4 Ma, respectively. This would indicate that biotite was formed at about 29 Ma by the thermal metamorphism which might have related with some magmatic activity. In this magmatic activity was caused by the subducting oceanic plate in the similar conditions at present, it seems to have occurred at a place too close to the present trench axis. This discrepancy could be explained by such processes as the change of the angle of the subducting plate, the moving of the trench axis by tectonic erosion and so on. However, more age data are required to solve this discrepancy. (author)

  12. The 40Ar/39Ar and K/Ar dating of lavas from the Hilo 1-km core hole, Hawaii Scientific Drilling Project

    Science.gov (United States)

    Sharp, W.D.; Turrin, B.D.; Renne, P.R.; Lanphere, M.A.

    1996-01-01

    Mauna Kea lava flows cored in the HilIo hole range in age from <200 ka to about 400 ka based on 40Ar/39Ar incremental heating and K-Ar analyses of 16 groundmass samples and one coexisting plagioclase. The lavas, all subaerially deposited, include a lower section consisting only of tholeiitic basalts and an upper section of interbedded alkalic, transitional tholeiitic, and tholeiitic basalts. The lower section has yielded predominantly complex, discordant 40Ar/39Ar age spectra that result from mobility of 40Ar and perhaps K, the presence of excess 40Ar, and redistribution of 39Ar by recoil. Comparison of K-Ar ages with 40Ar/39Ar integrated ages indicates that some of these samples have also lost 39Ar. Nevertheless, two plateau ages of 391 ?? 40 and 400 ?? 26 ka from deep in the hole, combined with data from the upper section, show that the tholeiitic section accumulated at an average rate of about 7 to 8 m/kyr and has an mean recurrence interval of 0.5 kyr/flow unit. Samples from the upper section yield relatively precise 40Ar/39Ar plateau and isotope correlation ages of 326 ?? 23, 241 ?? 5, 232 ?? 4, and 199 ?? 9 ka for depths of -415.7 m to -299.2 m. Within their uncertainty, these ages define a linear relationship with depth, with an average accumulation rate of 0.9 m/kyr and an average recurrence interval of 4.8 kyr/flow unit. The top of the Mauna Kea sequence at -280 m must be older than the plateau age of 132 ?? 32 ka, obtained for the basal Mauna Loa flow in the corehole. The upward decrease in lava accumulation rate is a consequence of the decreasing magma supply available to Mauna Kea as it rode the Pacific plate away from its magma source, the Hawaiian mantle plume. The age-depth relation in the core hole may be used to test and refine models that relate the growth of Mauna Kea to the thermal and compositional structure of the mantle plume.

  13. 40Ar/39Ar age of the Rotoiti Breccia and Rotoehu Ash, Okataina Volcanic Complex, New Zealand, and identification of heterogeneously distributed excess 40Ar in supercooled crystals

    DEFF Research Database (Denmark)

    Flude, Stephanie; Storey, Michael

    2016-01-01

    Co-magmatic granitoid clasts erupted as part of the Rotoiti Ignimbrite (Rotoehu Tephra) contain euhedral K-feldspar and biotite crystals that protrude into miarolytic cavities and show textural evidence for growth in super-cooled conditions and are thus interpreted as growing during eruption. 40Ar...... that appear to be largely unaffected by excess 40Ar. This population gives a statistically robust weighted mean age of 47.4 ± 1.5 ka (1σ, n = 13) and an indistinguishable inverse isochron age of 50 ± 3 ka for this historically difficult to date eruption. The weighted mean age is significantly younger than...... previous age estimates of the Rotoiti eruption obtained by K/Ar and 40Ar/39Ar dating of bracketing lavas, but is indistinguishable from recent 14C and (U–Th)/He dates and estimates based on orbital tuning and sedimentation rates constrained by 14C ages....

  14. Estimating NHL Scoring Rates

    OpenAIRE

    Buttrey, Samuel E.; Washburn, Alan R.; Price, Wilson L.; Operations Research

    2011-01-01

    The article of record as published may be located at http://dx.doi.org/10.2202/1559-0410.1334 We propose a model to estimate the rates at which NHL teams score and yield goals. In the model, goals occur as if from a Poisson process whose rate depends on the two teams playing, the home-ice advantage, and the manpower (power-play, short-handed) situation. Data on all the games from the 2008-2009 season was downloaded and processed into a form suitable for the analysis. The model...

  15. Structural, K-Ar and 40Ar-39Ar age studies of adularia K-feldspars from the Lizard Complex, England

    International Nuclear Information System (INIS)

    Halliday, A.N.; Mitchell, J.G.

    1976-01-01

    Conventional K-Ar analyses of fifteen adularia feldspars from the Lizard Complex yield ages between 181+-2 Ma and 220+-3 Ma (with one exception from Holseer Cove yielding an age of 156+-3 Ma). The feldspars are dominantly monoclinic but most contain a minor but constant proportion of triclinic material with variable triclinicity. An inverse correlation exists between triclinicity and K-Ar age interpreted as representing argon loss related to the structural state. Extrapolation of the data to zero triclinicity indicates a true age of 210-220 Ma. 40 Ar- 39 Ar stepwise degassing analyses yield plateau ages related to the K-Ar ages and not the crystallization age. The results can be explained in terms of postcrystallization Al-Si ordering resulting in argon loss from lattice sites which under normal diffusion conditions requires a range of activation energies. The Holseer Cove sample is monoclinic and an 40 Ar- 39 Ar stepheating analysis suggests a later crystallization at 160-170 Ma. Neither primary crystallization nor spontaneous ordering through time explain the origin of the triclinic adularia. It is suggested that ordering has been induced by the passage of low-temperature alkaline solutions at a subsequent point in geological time. Argon loss by ordering could explain the low ages found using both K-Ar and 40 Ar- 39 Ar stepheating methods when applied to feldspars in general. The 210-220 Ma, and 160-170 Ma hydrothermal events affected much of southwest England and are probably related to major geotectonic movements in western Europe. (Auth.)

  16. New palynology-based astronomical and revised 40Ar/39Ar ages for the Eocene maar lake of Messel (Germany)

    Science.gov (United States)

    Lenz, Olaf K.; Wilde, Volker; Mertz, Dieter F.; Riegel, Walter

    2015-04-01

    The annually laminated oil shale from the Eocene maar lake at Messel (Federal State of Hessen, Germany) provides unique paleoenvironmental data for a time interval of ~640 ka during the Paleogene greenhouse phase. As a consequence of orbitally controlled changes in the vegetation in the vicinity of the lake, the lacustrine laminites can now be astronomically tuned. Dating is based on the short eccentricity amplitude modulations of the regional pollen rain and their correlation to the astronomical La2010a/La2010d solutions in combination with a revised 40Ar/39Ar age of a basalt fragment from a lapilli tuff section below the first lacustrine sediments. Depending on different newly suggested ages for the Fish Canyon sanidine used as monitor for neutron irradiation, the age for the eruption at Messel is between 48.27 ± 0.22 and 48.11 ± 0.22 Ma. This allows for the first time the exact correlation of a Paleogene lacustrine sequence to the marine record in Central Europe. The Messel oil shale becomes now slightly older than previously assumed and includes the Ypresian/Lutetian boundary that moves the base of the European Land Mammal Age Geiseltalian (MP 11) into the Lower Eocene. This opens a window for establishing an independent chronostratigraphic framework for Paleogene terrestrial records and their correlation to the marine realm. Furthermore, the study reveals that higher amounts of pollen from "wet" and thermophilous plants indicate less seasonal and more balanced precipitation and slightly higher temperatures during a well-expressed eccentricity minimum.

  17. Molecular dynamic simulation of interaction of low-energy Ar and Xe ions with copper clusters at graphite surface

    International Nuclear Information System (INIS)

    Kornich, G.V.; Lozovskaya, L.I.; Betts, G.; Zaporozhchenko, V.I.; Faupel, F.

    2005-01-01

    One conducted molecular and dynamic simulation of sputtering of isolated clusters consisting of 13, 27 and 195 Cu atoms from the (0001) graphite surface by 200 eV energy Ar and Xe ions. It is shown that the factors of reflection of Ar and Xe ions from copper clusters differ from one another insignificantly, though the energy of the reflected Xe ions is essentially lower than that of Ar ions. The values of the factor of cluster sputtering by Xe ions are higher in contrast to sputtering by Ar ions. One identified two mechanisms of cluster sputtering resulting in the maximum of sputtering intensity at the polar angles near the normal one, and in periodicity of maximums within the azimuth distributions of sputtering intensity with 60 deg period [ru

  18. Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells.

    Directory of Open Access Journals (Sweden)

    Young-Chae Kim

    Full Text Available The androgen receptor (AR mediates the developmental, physiologic, and pathologic effects of androgens including 5α-dihydrotestosterone (DHT. However, the mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells are not well understood, though they are central to prostate development, homeostasis, and neoplasia. Here, we identify androgen-responsive genes that restrain cell cycle progression and proliferation of human prostate epithelial cell lines (HPr-1AR and PC3-Lenti-AR, and we investigate the mechanisms through which AR regulates their expression. DHT inhibited proliferation of HPr-1AR and PC3-Lenti-AR, and cell cycle analysis revealed a prolonged G1 interval. In the cell cycle, the G1/S-phase transition is initiated by the activity of cyclin D and cyclin-dependent kinase (CDK complexes, which relieve growth suppression. In HPr-1AR, cyclin D1/2 and CDK4/6 mRNAs were androgen-repressed, whereas CDK inhibitor, CDKN1A, mRNA was androgen-induced. The regulation of these transcripts was AR-dependent, and involved multiple mechanisms. Similar AR-mediated down-regulation of CDK4/6 mRNAs and up-regulation of CDKN1A mRNA occurred in PC3-Lenti-AR. Further, CDK4/6 overexpression suppressed DHT-inhibited cell cycle progression and proliferation of HPr-1AR and PC3-Lenti-AR, whereas CDKN1A overexpression induced cell cycle arrest. We therefore propose that AR-mediated growth suppression of HPr-1AR involves cyclin D1 mRNA decay, transcriptional repression of cyclin D2 and CDK4/6, and transcriptional activation of CDKN1A, which serve to decrease CDK4/6 activity. AR-mediated inhibition of PC3-Lenti-AR proliferation occurs through a similar mechanism, albeit without down-regulation of cyclin D. Our findings provide insight into AR-mediated regulation of prostate epithelial cell proliferation.

  19. Reappraisal of Los Humeros Volcanic Complex by New U/Th Zircon and 40Ar/39Ar Dating: Implications for Greater Geothermal Potential

    Science.gov (United States)

    Carrasco-Núñez, G.; Bernal, J. P.; Dávila, P.; Jicha, B.; Giordano, G.; Hernández, J.

    2018-01-01

    Longevity and size of magmatic systems are fundamental factors for assessing the potential of a geothermal field. At Los Humeros volcanic complex (LHVC), the first caldera-forming event was reported at 460 ± 40 ka. New zircon U/Th and plagioclase 40Ar/39Ar dates of pre-, syn- and postcaldera volcanics allow a reappraisal of the evolution of the geothermally active LHVC. The age of the voluminous Xaltipan ignimbrite (115 km3 dense rock equivalent [DRE]) associated with the formation of the Los Humeros caldera is now constrained by two geochronometers (zircon U/Th and plagioclase 40Ar/39Ar dating) to 164 ± 4.2 ka, which postdates a long episode of precaldera volcanism (rhyolitic domes), the oldest age of which is 693.0 ± 1.9 ka (40Ar/39Ar). The inferred short residence time (around 5 ka) for the paroxysmal Xaltipan ignimbrite is indicative of rapid assembly of a large magma body and rejuvenation of the system due to recurrent recharge magmas, as it has been occurred in some other large magmatic systems. Younger ages than previously believed have been obtained also for the other voluminous explosive phases of the Faby fall tuff at ˜70 ka and the second caldera-forming Zaragoza ignimbrite with 15 km3 DRE, which erupted immediately after. Thus, the time interval that separates the two caldera-forming episodes at Los Humeros is only 94 kyr, which is a much shorter interval than suggested by previous K-Ar dates (410 kyr). This temporal proximity allows us to propose a caldera stage encompassing the Xaltipan and the Zaragoza ignimbrites, followed by emplacement at 44.8 ± 1.7 ka of rhyolitic magmas interpreted to represent a postcaldera, resurgent stage. Rhyolitic eruptions have also occurred during the Holocene (˜1,200 km3) and these new ages indicating much younger caldera-forming volcanism than previously believed are fundamental factors in the application of classical conductive models of heat resource, enhancing the heat production capacity and favor a higher

  20. Etching properties of BLT films in CF4/Ar plasma

    International Nuclear Information System (INIS)

    Kim, Dong Pyo; Kim, Kyoung Tae; Kim, Chang Il

    2003-01-01

    CF 4 /Ar plasma mass content and etching rate behavior of BLT thin films were investigated in inductively coupled plasma (ICP) reactor as functions of CF 4 /Ar gas mixing ratio, rf power, and dc bias voltage. The variation of relative volume densities for F and Ar atoms were measured by the optical emission spectroscopy (OES). The etching rate as functions of Ar content showed the maximum of 803 A/min at 80 % Ar addition into CF 4 plasma. The presence of maximum etch rate may be explained by the concurrence of two etching mechanisms such as physical sputtering and chemical reaction. The role of Ar ion bombardment includes destruction of metal (Bi, La, Ti)-O bonds as well as support of chemical reaction of metals with fluorine atoms

  1. The International Bleeding Risk Score

    DEFF Research Database (Denmark)

    Laursen, Stig Borbjerg; Laine, L.; Dalton, H.

    2017-01-01

    The International Bleeding Risk Score: A New Risk Score that can Accurately Predict Mortality in Patients with Upper GI-Bleeding.......The International Bleeding Risk Score: A New Risk Score that can Accurately Predict Mortality in Patients with Upper GI-Bleeding....

  2. Performance and blood monitoring in sports: the artificial intelligence evoking target testing in antidoping (AR.I.E.T.T.A.) project.

    Science.gov (United States)

    Manfredini, A F; Malagoni, A M; Litmanen, H; Zhukovskaja, L; Jeannier, P; Dal Follo, D; Felisatti, M; Besseberg, A; Geistlinger, M; Bayer, P; Carrabre, J E

    2011-03-01

    Substances and methods used to increase oxygen blood transport and physical performance can be detected in the blood, but the screening of the athletes to be tested remains a critical issue for the International Federations. This project, AR.I.E.T.T.A., aimed to develop a software capable of analysing athletes' hematological and performance profiles to detect abnormal patterns. One-hundred eighty athletes belonging to the International Biathlon Union gave written informed consent to have their hematological data, previously collected according to anti-doping rules, used to develop the AR.I.E.T.T.A. software. Software was developed with the included sections: 1) log-in; 2) data-entry: where data are loaded, stored and grouped; 3) analysis: where data are analysed, validated scores are calculated, and parameters are simultaneously displayed as statistics, tables and graphs, and individual or subpopulation profiles; 4) screening: where an immediate evaluation of the risk score of the present sample and/or the athlete under study is obtained. The sample risk score or AR.I.E.T.T.A. score is calculated by a simple computational system combining different parameters (absolute values and intra-individual variations) considered concurrently. The AR.I.E.T.T.A. score is obtained by the sum of the deviation units derived from each parameter, considering the shift of the present value from the reference values, based on the number of standard deviations. AR.I.E.T.T.A. enables a quick evaluation of blood results assisting surveillance programs and perform timely target testing controls on athletes by the International Federations. Future studies aiming to validate the AR.I.E.T.T.A. score and improve the diagnostic accuracy will improve the system.

  3. HIGH-RESOLUTION FOURIER TRANSFORM SPECTROSCOPY OF LANTHANUM IN Ar DISCHARGE IN THE NEAR-INFRARED

    Energy Technology Data Exchange (ETDEWEB)

    Güzelçimen, F.; Başar, Gö. [Faculty of Science, Physics Department, Istanbul University, Tr-34134 Vezneciler, Istanbul (Turkey); Tamanis, M.; Kruzins, A.; Ferber, R. [Laser Centre, The University of Latvia, Rainis Boulevard 19, LV-1586 Riga (Latvia); Windholz, L. [Institut für Experimentalphysik, Technische Universität Graz, A-8010 Graz, Petersgasse 16 (Austria); Kröger, S., E-mail: gbasar@istanbul.edu.tr, E-mail: sophie.kroeger@htw-berlin.de [Hochschule für Technik und Wirtschaft Berlin, Wilhelminenhofstr. 75A, D-12459 Berlin (Germany)

    2013-10-01

    A high-resolution spectrum of lanthanum has been recorded by a Fourier Transform spectrometer in the wavelength range from 833 nm to 1666 nm (6000 cm{sup –1} to 12,000 cm{sup –1}) using as light source a hollow cathode lamp operated with argon as the discharge carrier gas. In total, 2386 spectral lines were detected in this region, of which 555 lines could be classified as La I transitions and 10 lines as La II transitions. All La II transitions and 534 of these La I transitions were classified for the first time, and 6 of the La II transitions and 433 of the classified La I transitions appear to be new lines, which could not be found in the literature. The corresponding energy level data of classified lines are given. Additionally, 430 lines are assigned as Ar I lines and 394 as Ar II lines, of which 179 and 77, respectively, were classified for the first time. All 77 classified Ar II transitions as well as 159 of the classified Ar I transitions are new lines. Furthermore, the wavenumbers of 997 unclassified spectral lines were determined, 235 of which could be assigned as La lines, because of their hyperfine pattern. The remaining 762 lines may be either unclassified Ar lines or unresolved and unclassified La lines with only one symmetrical peak with an FWHM in the same order of magnitude as the Ar lines. The accuracy of the wavenumber for the classified lines with signal-to-noise-ratio higher than four is better than 0.006 cm{sup –1} which corresponds to an accuracy of 0.0004 nm at 830 nm and 0.0017 nm at 1660 nm, respectively.

  4. Ar-37 in the Atmospheric and Sub-Soil Gases

    International Nuclear Information System (INIS)

    Purtschert, R.; Raghoo, L.S.

    2015-01-01

    On-site inspection of the radioactive noble gas isotope 37Ar is a definitive and unambiguous indicator of an underground nuclear explosion. 37Ar is produced underground by neutron activation of calcium by the reaction 40Ca(n,α)37Ar. In the atmosphere, 37Ar is produced by the spallation reaction 40Ar(n,4n)37Ar. Periodic measurements over the last six years on air collected in Bern revealed a background level in the order of 1-5 mBq/m 3 air in agreement with former findings and theoretical calculations. Those calculations also indicated that the intrusion of stratospheric air masses may lead to elevated tropospheric 37Ar concentrations up to 8-10 mBq/m 3 air. Selected samples taken up to now in the vicinity of nuclear power plants revealed no significant deviation from the natural background. In order to distinguish between natural and artificially elevated 37Ar the location-specific 37Ar activity range in soils, rocks and the atmosphere were identified. From CARIBIC flights, a passenger aircraft with a special air freight container filled with scientific equipment in the cargo compartment, tropospheric air samples were analyzed for 37Ar and 85Kr. The natural 37Ar production in soils and the rock basement underlying the alluvium is investigated by means of in situ measurements of different isotopes, theoretical calculations and irradiation experiments on selected rock samples. This will help resolve the temporal evolution and/or constancy of the natural 37Ar background and allow for an interpretation in terms of the identification of clandestine nuclear explosions. (author)

  5. Cross sections of the 36Ar(d,α)34mCl, 40Ar(d,α)38Cl, and 40Ar(d,p)41Ar nuclear reactions below 8.4 MeV.

    Science.gov (United States)

    Engle, J W; Severin, G W; Barnhart, T E; Knutson, L D; Nickles, R J

    2012-02-01

    We have measured the cross section for production of the medically interesting isotope (34m)Cl, along with (38)Cl and (41)Ar, using deuteron bombardments of (36)Ar and (40)Ar below 8.4 MeV. ALICE/ASH analytical codes were employed to determine the shape of nuclear excitation functions, and experiments were performed using the University of Wisconsin tandem electrostatic accelerator to irradiate thin targets of argon gas. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Cross Sections of the 36Ar(d,α)34mCl, 40Ar(d,α)38Cl and 40Ar(d,p)41Ar Nuclear Reactions below 8.4 MeV

    Science.gov (United States)

    Engle, J W; Severin, G W; Barnhart, T E; Knutson, L D; Nickles, R J

    2011-01-01

    We have measured the cross section for production of the medically interesting isotope 34mCl, along with 38Cl and 41Ar, using deuteron bombardments of 36Ar and 40Ar below 8.4 MeV. ALICE/ASH analytical codes were employed to determine the shape of nuclear excitation functions, and experiments were performed using the University of Wisconsin tandem electrostatic accelerator to irradiate thin targets of argon gas. PMID:22041299

  7. Progress on using deuteron-deuteron fusion generated neutrons for 40Ar/39Ar sample irradiation

    Science.gov (United States)

    Rutte, Daniel; Renne, Paul R.; Becker, Tim; Waltz, Cory; Ayllon Unzueta, Mauricio; Zimmerman, Susan; Hidy, Alan; Finkel, Robert; Bauer, Joseph D.; Bernstein, Lee; van Bibber, Karl

    2017-04-01

    We present progress on the development and proof of concept of a deuteron-deuteron fusion based neutron generator for 40Ar/39Ar sample irradiation. Irradiation with deuteron-deuteron fusion neutrons is anticipated to reduce Ar recoil and Ar production from interfering reactions. This will allow dating of smaller grains and increase accuracy and precision of the method. The instrument currently achieves neutron fluxes of ˜9×107 cm-2s-1 as determined by irradiation of indium foils and use of the activation reaction 115In(n,n')115mIn. Multiple foils and simulations were used to determine flux gradients in the sample chamber. A first experiment quantifying the loss of 39Ar is underway and will likely be available at the time of the presentation of this abstract. In ancillary experiments via irradiation of K salts and subsequent mass spectrometric analysis we determined the cross-sections of the 39K(n,p)39Ar reaction at ˜2.8 MeV to be 160 ± 35 mb (1σ). This result is in good agreement with bracketing cross-section data of ˜96 mb at ˜2.45 MeV and ˜270 mb at ˜4 MeV [Johnson et al., 1967; Dixon and Aitken, 1961 and Bass et al. 1964]. Our data disfavor a much lower value of ˜45 mb at 2.59 MeV [Lindström & Neuer, 1958]. In another ancillary experiment the cross section for 39K(n,α)36Cl at ˜2.8 MeV was determined as 11.7 ± 0.5 mb (1σ), which is significant for 40Ar/39Ar geochronology due to subsequent decay to 36Ar as well as for the determination of production rates of cosmogenic 36Cl. Additional experiments resolving the cross section functions on 39K between 1.5 and 3.6 MeV are on their way using the LICORNE neutron source of the IPN Orsay tandem accelerator. Results will likely be available at the time of the presentation of this abstract. While the neutron generator is designed for fluxes of ˜109 cm-2s-1, arcing in the sample chamber currently limits the power—straightforwardly correlated to the neutron flux—the generator can safely be run at. Further

  8. Electron relaxation properties of Ar magnetron plasmas

    Science.gov (United States)

    Xinjing, CAI; Xinxin, WANG; Xiaobing, ZOU

    2018-03-01

    An understanding of electron relaxation properties in plasmas is of importance in the application of magnetrons. An improved multi-term approximation of the Boltzmann equation is employed to study electron transport and relaxation properties in plasmas. Elastic, inelastic and nonconservative collisions between electrons and neutral particles are considered. The expressions for the transport coefficients are obtained using the expansion coefficients and the collision operator term. Numerical solutions of the matrix equations for the expansion coefficients are also investigated. Benchmark calculations of the Reid model are presented to demonstrate the accuracy of the improved multi-term approximation. It is shown that the two-term approximation is generally not accurate enough and the magnetic fields can reduce the anisotropy of the velocity distribution function. The electron relaxation properties of Ar plasmas in magnetrons for various magnetic fields are studied. It is demonstrated that the energy parameters change more slowly than the momentum parameters.

  9. Sensibility of different wheat varieties (strains) to Ar+ implantation

    International Nuclear Information System (INIS)

    Cui Huanhu; Jing Hua; Ma Aiping; Kang Xiuli; Yang Liping; Huang Mingjing; Ma Buzhou; Shanxi Academy of Agricultural Sciences, Taiyuan

    2005-01-01

    The sensibility of different wheat varieties (strains) to Ar + implantation was studied. The results showed that the survival rate of 21 wheat varieties (strains) at the dose of 6 x 10 16 Ar + /cm 2 could be divided into five groups: surplus sensitive varieties (strains), sensitive varieties (strains), transitional varieties (strains), obtuse varieties (strains) and surplus obtuse varieties (strains). The sensibility of wheat varieties (strains) to Ar + injection is high-moisture-fertility wheat varieties (strains) > medium-moisture-fertility wheat varieties (strains) > dry land wheat varieties (strains). The study has provided theoretical basis in induced mutation medial lethal dose of different wheat varieties (strains) to Ar + implantation. (authors)

  10. Tibetan tectonics from 40Ar/39Ar analysis of a single K-feldspar sample

    International Nuclear Information System (INIS)

    Richter, F.M.; Lovera, O.M.; Harrison, T.M.; Copeland, P.

    1991-01-01

    40 Ar/ 39 Ar data on an alkali feldspar sample from the Quxu pluton, Gangdese batholith, southern Tibet, allow a detailed assessment of unroofing and uplift history between 35 and 18 Ma. The 39 Ar Arrhenius plot for this sample shows departures from a linear relationship between the effective diffusion parameter, log(D/r 2 ), and reciprocal temperature, which we interpret to be the result of a distribution of distinct diffusion-domain sizes. We use an alternative way of plotting the Arrhenius data that exhibits domain size versus cumulative % 39 Ar released during step heating. The 40 Ar/ 39 Ar age spectrum of the sample has features, such as local age plateaus, that are most easily explained in terms of the distinctive closure age of particular domains. The fact that the same distribution of diffusion-domain sizes explains both the Arrhenius data and the age spectrum is an indication that the diffusion properties operating in the laboratory are those of the sample while it was in its natural environment. Modelling of the age spectrum with a distribution of domain sizes results in the recovery of a continuous cooling-history segment rather than a single time-temperature datum. We demonstrate the robustness of the cooling-curve determination by showing the large misfits to the age spectrum that arise from relatively small changes in the cooling history. The best-fit cooling curve for the Quxu sample shows a decreasing rate of cooling in the time interval 35-18 Ma, followed by a very rapid cooling beginning at about 18 Ma. We have used a thermal model for the conductive cooling of an unroofing pluton to estimate the rate of unroofing required to explain the Quxu cooling curve, and find that in the 35-20 Ma time interval, the primary control of the thermal evolution is the conductive loss of magmatic heat with little or no unroofing (unroofing rates of approximately 0.05 mm/yr) followed by a brief period (<5 Ma) of very rapid unroofing with rates of order 2 mm

  11. Experimental system to measure excitation cross-sections by electron impact. Measurements for ArI and ArII

    International Nuclear Information System (INIS)

    Blanco, F.; Sanchez, J.A.; Aguilera, J.A.; Campos, J.

    1989-01-01

    An experimental set-up to measure excitation cross-section of atomic and molecular levels by electron impact based on the optical method is reported. We also present some measurements on the excitation cross-section for ArI 5p'(1/2)0 level, and for simultaneous ionization and excitation of Ar leading to ArII levels belonging to the 3p 4 4p and 3p 4 4d configurations. (Author)

  12. Acute Radiation Syndrome (ARS) and its harmful effects on human health

    International Nuclear Information System (INIS)

    Khanam, Yasmin; Singh, Yogender

    2012-01-01

    After radiation exposure a series of many clinical syndromes appear that is called as Acute Radiation Syndrome (ARS). ARS also known as radiation toxicology or radiation sickness. Both low and higher doses radiation exposure on human body cause different types of radiation syndromes. These radiations may be ionizing radiations. X-rays and gamma rays etc. some times neutrons or radionuclides may also be deposited in human body and their effective doses cause major injuries or abnormalities even sometimes death also. ARS consist of a sequence of phased symptoms. These symptoms appear after the radiation exposure for several days to several months or sometimes for a long period or years. ARS depends on the quantity of absorbed radiation dose (rad0). ARS is characterized by an initial prodromal stage of malaise, nausea, vomiting, and diarrhea. Critical effects of ARS are Hematologic, that results infections to low white blood cells (WBC), bleeding due to low platelets and anemia due to low red blood cells (RBC), Gastrointestinal results nausea, vomiting, loss of appetite and abdominal pain (exposure doses of 600-1000 rad) and Neurovascular depending on the exposure dose. Neurovascular syndrome typically occurs at exposure doses greater than 1000 rad. It presents with neurological symptoms such as dizziness, headache, or decreased level of consciousness with an absence of vomiting. The clinical course of radiation sickness following a single intensive exposure to whole body radiation is characterized by three successive phases; a prodromal phase, which develops within minutes or hours after exposure, an ensuring latent period, which is relatively asymptomatic; and the main phase of the illness. Complete Blood Count (CBC) are helpful for the diagnosis for ARS. ARS may cause skin damage or loss of epidermis. Person suffering from nausea, vomiting, diarrhea should be admitted to well equipped hospitals or clinics. High exposured persons should be analysed CBC. Their

  13. An 40 Ar- 39 Ar study of the Cape Verde hot spot

    DEFF Research Database (Denmark)

    Holm, Paul Martin; Grandvuinet, Tanja; Wilson, James Richard

    2008-01-01

    The 40Ar-39Ar analyses of 28 groundmass separates from volcanic rocks from the islands of Santiago, Sal, and São Vicente, Cape Verde archipelago, are presented. The new age data record the volcanic evolution for Santiago from 4.6 to 0.7 Ma, for Sal from around 15 to 1.1 Ma, and for São Vicente from...... Cretaceous age for limestones deposited on the seafloor and later uplifted. The Cape Verde Rise is indicated to have fully formed in the early Miocene around 22 Ma, accompanied by the initial alkaline volcanism. Considerable volcanism on Sal, Boa Vista, and Maio took place in the Miocene and Pliocene...

  14. Acoustic resonance spectroscopy (ARS): ARS300 operations manual, software version 2.01

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-25

    Acoustic Resonance Spectroscopy (ARS) is a nondestructive evaluation technology developed at the Los Alamos National Laboratory. The ARS technique is a fast, safe, and nonintrusive technique that is particularly useful when a large number of objects need to be tested. Any physical object, whether solid, hollow, or fluid filled, has many modes of vibration. These modes of vibration, commonly referred to as the natural resonant modes or resonant frequencies, are determined by the object`s shape, size, and physical properties, such as elastic moduli, speed of sound, and density. If the object is mechanically excited at frequencies corresponding to its characteristic natural vibrational modes, a resonance effect can be observed when small excitation energies produce large amplitude vibrations in the object. At other excitation frequencies, i.e., vibrational response of the object is minimal.

  15. Laser-fusion 40Ar/39Ar Ages of Darwin Impact Glass

    Science.gov (United States)

    Lo, Ching-Hua; Howard, Kieren T.; Chung, Sun-Lin; Meffre, Sebastien

    2002-11-01

    Three samples of Darwin Glass, an impact glass found in Tasmania, Australia at the edge of the Australasian tektite strewn field were dated using the 40Ar/39Ar single-grain laser fusion technique, yielding isochron ages of 796-815 ka with an overall weighted mean of 816 ± 7 ka. These data are statistically indistinguishable from those recently reported for the Australasian tektites from Southeast Asia and Australia (761-816 ka; with a mean weighted age of 803 ± 3 ka). However, considering the compositional and textural differences and the disparity from the presumed impact crater area for Australasian tektites, Darwin Glass is more likely to have resulted from a distinct impact during the same period of time.

  16. PepArML: A Meta-Search Peptide Identification Platform for Tandem Mass Spectra.

    Science.gov (United States)

    Edwards, Nathan J

    2013-12-01

    The PepArML meta-search peptide identification platform for tandem mass spectra provides a unified search interface to seven search engines; a robust cluster, grid, and cloud computing scheduler for large-scale searches; and an unsupervised, model-free, machine-learning-based result combiner, which selects the best peptide identification for each spectrum, estimates false-discovery rates, and outputs pepXML format identifications. The meta-search platform supports Mascot; Tandem with native, k-score and s-score scoring; OMSSA; MyriMatch; and InsPecT with MS-GF spectral probability scores—reformatting spectral data and constructing search configurations for each search engine on the fly. The combiner selects the best peptide identification for each spectrum based on search engine results and features that model enzymatic digestion, retention time, precursor isotope clusters, mass accuracy, and proteotypic peptide properties, requiring no prior knowledge of feature utility or weighting. The PepArML meta-search peptide identification platform often identifies two to three times more spectra than individual search engines at 10% FDR.

  17. 40Ar/39Ar dating and paleo-magnetism of traps from Ethiopia, Deccan and Siberia

    International Nuclear Information System (INIS)

    Hofmann, C.

    1997-01-01

    Recent studies have shown that major flood basalt provinces have been emplaced as short events (∼ 1 Myr), more or less synchronous with climatic crises and mass extinctions. We present new geochronologic ( 40 Ar/ 39 Ar) and magneto-stratigraphic results for the Ethiopian traps, one of the last remaining flood basalts for which little of such data were available. The ages obtained in a 2000 m thick section are indistinguishable. Moreover, magneto-stratigraphy reveals a simple 3-chron reverse-normal-reverse sequence. Although magnetic chrons cannot be yet unambiguously identified, there is more likelihood for the normal sub-chron in the main basaltic pile to correspond to 11N, supporting a brief duration (less than 1.5 Ma). The Ethiopian traps erupted near 30 Ma at or near the time of the cold and dry climate, major Antarctic ice sheet advance, and the largest sea-level drop in the Tertiary. Bhandari et al. (GRL, 1995) have discovered inter-traps sediments with a triple iridium anomaly in a series of seven basaltic lava flows in the Kutch area of the North Western Deccan traps of India. Plagioclases from three flows above the iridium bearing sediments yield 39 Ar/ 40 Ar plateau ages near 65.0 Ma: these flows have unambiguously reversed magnetic polarity interpreted as chron 29R. As a preliminary summary, evidence of the KTB asteroid impact is confirmed in the Deccan traps, showing that they are coeval events in a general sense (in a Ma long window) though clearly with vastly different time constants. This is compatible with paleontologic evidence of two scales of extinctions, one quasi-instantaneous and the other on the order of 10 5 to 10 6 yrs. Clearly, the impact cannot have caused trap eruptions. On the other hand, the exact age and significance of the lower flows more altered remains to be analyzed further as they pertained to the much debated question of duration of Deccan trap volcanism. (author)

  18. Spatial autocorrelation method using AR model; Kukan jiko sokanho eno AR model no tekiyo

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, H; Obuchi, T; Saito, T [Iwate University, Iwate (Japan). Faculty of Engineering

    1996-05-01

    Examination was made about the applicability of the AR model to the spatial autocorrelation (SAC) method, which analyzes the surface wave phase velocity in a microtremor, for the estimation of the underground structure. In this examination, microtremor data recorded in Morioka City, Iwate Prefecture, was used. In the SAC method, a spatial autocorrelation function with the frequency as a variable is determined from microtremor data observed by circular arrays. Then, the Bessel function is adapted to the spatial autocorrelation coefficient with the distance between seismographs as a variable for the determination of the phase velocity. The result of the AR model application in this study and the results of the conventional BPF and FFT method were compared. It was then found that the phase velocities obtained by the BPF and FFT methods were more dispersed than the same obtained by the AR model. The dispersion in the BPF method is attributed to the bandwidth used in the band-pass filter and, in the FFT method, to the impact of the bandwidth on the smoothing of the cross spectrum. 2 refs., 7 figs.

  19. A Framework for Designing Collaborative Learning Environments Using Mobile AR

    Science.gov (United States)

    Cochrane, Thomas; Narayan, Vickel; Antonczak, Laurent

    2016-01-01

    Smartphones provide a powerful platform for augmented reality (AR). Using a smartphone's camera together with the built in GPS, compass, gyroscope, and touch screen enables the real world environment to be overlaid with contextual digital information. The creation of mobile AR environments is relatively simple, with the development of mobile AR…

  20. A phase one AR/C system design

    Science.gov (United States)

    Kachmar, Peter M.; Polutchko, Robert J.; Matusky, Martin; Chu, William; Jackson, William; Montez, Moises

    1991-01-01

    The Phase One AR&C System Design integrates an evolutionary design based on the legacy of previous mission successes, flight tested components from manned Rendezvous and Proximity Operations (RPO) space programs, and additional AR&C components validated using proven methods. The Phase One system has a modular, open architecture with the standardized interfaces proposed for Space Station Freedom system architecture.

  1. Electron temperatures of inductively coupled Cl2-Ar plasmas

    International Nuclear Information System (INIS)

    Fuller, N.C.M.; Donnelly, Vincent M.; Herman, Irving P.

    2002-01-01

    Trace rare gases optical emission spectroscopy has been used to measure the electron temperature, T e , in a high-density inductively coupled Cl 2 -Ar plasma at 18 mTorr as function of the 13.56 MHz radio frequency power and Ar fraction. Only the Kr and Xe emission lines were used to determine T e , because of evidence of radiation trapping when the Ar emission lines were also used for larger Ar fractions. At 600 W (10.6 W cm-2), T e increases from ∼4.0±0.5 eV to ∼6.0±2.0 eV as the Ar fraction increases from 1% to 96%. In the H (inductive, bright) mode, T e , for a 'neat' chlorine plasma (including 1% of each He/Ne/Ar/Kr/Xe) increases only slightly from ∼3.8 to 4.0 eV as power increases from 450 to 750 W. This increase is much larger for larger Ar fractions, such as from ∼4.0 to 7.3 eV for 78% Ar. Most of these effects can be understood using the fundamental particle balance equation

  2. AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

    Science.gov (United States)

    Aceto, Nicola; Bardia, Aditya; Wittner, Ben S; Donaldson, Maria C; O'Keefe, Ryan; Engstrom, Amanda; Bersani, Francesca; Zheng, Yu; Comaills, Valentine; Niederhoffer, Kira; Zhu, Huili; Mackenzie, Olivia; Shioda, Toshi; Sgroi, Dennis; Kapur, Ravi; Ting, David T; Moy, Beverly; Ramaswamy, Sridhar; Toner, Mehmet; Haber, Daniel A; Maheswaran, Shyamala

    2018-04-01

    Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells (CTC) isolated from blood samples of women with metastatic estrogen receptor (ER) + breast cancer, comparing cases with progression in bone versus visceral organs. Among the activated cellular pathways in CTCs from bone-predominant breast cancer is androgen receptor (AR) signaling. AR gene expression is evident, as is its constitutively active splice variant AR-v7. AR expression within CTCs is correlated with the duration of treatment with aromatase inhibitors, suggesting that it contributes to acquired resistance to endocrine therapy. In an established breast cancer xenograft model, a bone-tropic derivative displays increased AR expression, whose genetic or pharmacologic suppression reduces metastases to bone but not to lungs. Together, these observations identify AR signaling in CTCs from women with bone-predominant ER + breast cancer, and provide a rationale for testing androgen inhibitors in this subset of patients. Implications: This study highlights a role for the AR in breast cancer bone metastasis, and suggests that therapeutic targeting of the AR may benefit patients with metastatic breast cancer. Mol Cancer Res; 16(4); 720-7. ©2018 AACR . ©2018 American Association for Cancer Research.

  3. 37Ar monitoring techniques and on-site inspection system

    International Nuclear Information System (INIS)

    Duan Rongliang; Chen Yinliang; Li Wei; Wang Hongxia; Hao Fanhua

    2001-01-01

    37 Ar is separated, purified and extracted from air sample with a low temperature gas-solid chromatographic purifying method, prepared into a radioactive measurement source and its radioactivity is measured with a proportional counter. Based on the monitoring result, a judgement can be made if an nuclear explosion event has happened recently in a spectabilis area. A series of element techniques that are associated the monitoring of the trace element 37 Ar have been investigated and developed. Those techniques include leaked gas sampling, 37 Ar separation and purification, 37 Ar radioactivity measurement and the on-site inspection of 37 Ar. An advanced 37 Ar monitoring method has been developed, with which 200 liters of air can be treated in 2 hours with sensitivity of 0.01 Bq/L for 37 Ar radioactivity measurement. A practical 37 Ar On-site Inspection system has been developed. This research work may provide technical and equipment support for the verification protection, verification supervision and CTBT verification

  4. 40Ar/39Ar geochronology of the El Teniente porphyry copper deposit

    International Nuclear Information System (INIS)

    Maksaev, V; Munizaga, F; McWilliams, M; Thiele, K; Arevalo, A; Zuniga, P; Floody, R

    2001-01-01

    breccias. Phyllic alteration primarily occurs as quartz-sericite haloes of quartz-sulfide-sulfate veinlets within the perimeter of the orebody, and slightly overprints potassic alteration. Propylitic alteration occurs largely peripheral to ore-grade rock. The relatively restricted development of phyllic alteration and the occurrence of the central breccia conflict with the classic porphyry copper model of Lowell and Gilbert (1970), but El Teniente may be regarded as a 'variation on a theme' of the classic model, as suggested by Gustafson and Hunt (1975). The exceedingly large size of the El Teniente deposit, coupled with its apparently young mineralization age prompted us to initiate a systematic 40 Ar/ 39 Ar study whose goals are to determine the age(s) of the hydrothermal event(s) that produced such a remarkable copper concentration and ultimately to estimate the duration of the hydrothermal activity at El Teniente. This is particularly relevant to an understanding of the processes that formed super-giant high-grade copper deposits in the Chilean Andes and elsewhere. We report here 32 total fusion 40 Ar/ 39 Ar ages from sericite and biotite from different lithologic units of El Teniente and five step-heating 40 Ar- 39 Ar ages of samples previously dated using conventional K-Ar methods (Cuadra, 1986) (au)

  5. Symptoms of Allergic Rhinitis in Women during Early Pregnancy Are Associated with Higher Prevalence of Allergic Rhinitis in Their Offspring

    Directory of Open Access Journals (Sweden)

    Miwa Shinohara

    2007-01-01

    Results: Offspring whose mothers had any AR symptoms during early pregnancy showed a significantly higher adjusted odds ratio for the onset of AR in offspring than those whose mothers had no symptoms during pregnancy (adjusted Odds Ratio: 6.26, p=0.036. However, the symptoms of AR during late pregnancy showed no effects on the odds ratio. In contrast, the presence or absence of AR symptoms during early or late pregnancy showed no association with the prevalence of food allergy, atopic dermatitis or asthma in offspring. Conclusions: Our results suggest the presence of possible epigenetic mechanisms regulating the onset of AR in humans presumably through increased organ-specific hypersensitivity.

  6. arXiv On higher order and anisotropic hydrodynamics for Bjorken and Gubser flows

    CERN Document Server

    Chattopadhyay, Chandrodoy; Pal, Subrata; Vujanovic, Gojko

    2018-06-15

    We study the evolution of hydrodynamic and nonhydrodynamic moments of the distribution function using anisotropic and third-order Chapman-Enskog hydrodynamics for systems undergoing Bjorken and Gubser flows. The hydrodynamic results are compared with the exact solution of the Boltzmann equation with a collision term in relaxation time approximation. While the evolution of the hydrodynamic moments of the distribution function (i.e., of the energy momentum tensor) can be described with high accuracy by both hydrodynamic approximation schemes, their description of the evolution of the entropy of the system is much less precise. We attribute this to large contributions from nonhydrodynamic modes coupling into the entropy evolution, which are not well captured by the hydrodynamic approximations. The differences between the exact solution and the hydrodynamic approximations are larger for the third-order Chapman-Enskog hydrodynamics than for anisotropic hydrodynamics, which effectively resums some of the dissipativ...

  7. Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

    Science.gov (United States)

    Chang, Chawnshang; Lee, Soo Ok; Wang, Ruey-Sheng; Yeh, Shuyuan; Chang, Ta-Min

    2013-01-01

    ABSTRACT Androgens/androgen receptor (AR) signaling is involved primarily in the development of male-specific phenotypes during embryogenesis, spermatogenesis, sexual behavior, and fertility during adult life. However, this signaling has also been shown to play an important role in development of female reproductive organs and their functions, such as ovarian folliculogenesis, embryonic implantation, and uterine and breast development. The establishment of the testicular feminization (Tfm) mouse model exploiting the X-linked Tfm mutation in mice has been a good in vivo tool for studying the human complete androgen insensitivity syndrome, but this mouse may not be the perfect in vivo model. Mouse models with various cell-specific AR knockout (ARKO) might allow us to study AR roles in individual types of cells in these male and female reproductive systems, although discrepancies are found in results between labs, probably due to using various Cre mice and/or knocking out AR in different AR domains. Nevertheless, no doubt exists that the continuous development of these ARKO mouse models and careful studies will provide information useful for understanding AR roles in reproductive systems of humans and may help us to develop more effective and more specific therapeutic approaches for reproductive system-related diseases. PMID:23782840

  8. Do Test Scores Buy Happiness?

    Science.gov (United States)

    McCluskey, Neal

    2017-01-01

    Since at least the enactment of No Child Left Behind in 2002, standardized test scores have served as the primary measures of public school effectiveness. Yet, such scores fail to measure the ultimate goal of education: maximizing happiness. This exploratory analysis assesses nation level associations between test scores and happiness, controlling…

  9. Photoionization of Ar2 at high resolution

    International Nuclear Information System (INIS)

    Dehmer, P.M.

    1982-01-01

    The relative photoionization cross section of Ar 2 was determined at a resolution of 0.07 A in the wavelength region from 800 to 850 A using a new photoionization mass spectrometer that combines a high intensity helium continuum lamp with a free supersonic molecular beam source. In the region studied, the photoionization cross section is dominated by autoionization of molecular Rydberg states, and the structure is diffuse owing to the combined effects of autoionization and predissociation. The molecular photoionization spectrum is extremely complex and shows little resemblence either to the corresponding atomic spectrum (indicating that the spectrum of the dimer is not simply a perturbed atomic spectrum) or to the molecular absorption spectrum at longer wavelengths. The regular vibrational progressions seen at longer wavelengths are absent above the first ionization potential. Detailed spectroscopic analysis is possible for only a small fraction of the observed features; however, vibrational intervals of 50--100 cm -1 suggest that some of the Rydberg states have B 2 Pi/sub 3/2g/ ionic cores. A comparison of the absorption and photoionization spectra shows that, at wavelengths shorter than approx.835 A, many of the excited states decay via mechanisms other than autoionization

  10. Molecular dynamics study of the effect of substrate temperature and Ar ion assisted deposition on the deposition of amorphous TiO_2 films

    International Nuclear Information System (INIS)

    Chen, Xian; Zhang, Jing; Zhao, Yu-Qing

    2017-01-01

    Highlights: • The surface roughness of a-TiO_2 films is decreased with the increment of the Ar ion assisted energy. • The surface roughness of a-TiO_2 films is decreased with higher substrate temperature when the substrate has an island structure. • The assisted Ar ion has power of making a flat surface and increasing the local temperature. • The assisted Ar ion will influence the growth mode with the change of surface atom mobility. • The Volmer-Weber (island) growth mode is inhibited with a high assisted Ar ion energy. - Abstract: This paper has investigated the impact of the substrate temperature and Ar ion assisted deposition on the surface structure formation mechanism and the film properties during the amorphous TiO_2 thin film deposition process with the molecular dynamics simulation method. The results show that the reduction of the surface roughness happen when the energy of Ar ions assisted is increased or the substrate temperature rises, and also the film density on surface is changed with the increasing of Ar ions energy and substrate temperature. It is also found that the Volmer-Weber (island) growth mode of films is promoted by the lower Ar ion energy and higher substrate temperature when the substrate has an island structure. The assisted Ar ion has power of making a flat surface and increasing the local temperature. Besides, it will influence the growth mode with the change of surface atom mobility. With a high assisted Ar ion energy the Volmer-Weber (island) growth mode is inhibited, which will be conducive to the formation of more smooth film surface.

  11. Molecular dynamics study of the effect of substrate temperature and Ar ion assisted deposition on the deposition of amorphous TiO{sub 2} films

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xian, E-mail: mus_c@qq.com [Science and Technology on Analog Integrated Circuit Laboratory, ChongQing, 401332 (China); Zhang, Jing [Science and Technology on Analog Integrated Circuit Laboratory, ChongQing, 401332 (China); Zhao, Yu-Qing [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi’AN, 710049 (China)

    2017-05-15

    Highlights: • The surface roughness of a-TiO{sub 2} films is decreased with the increment of the Ar ion assisted energy. • The surface roughness of a-TiO{sub 2} films is decreased with higher substrate temperature when the substrate has an island structure. • The assisted Ar ion has power of making a flat surface and increasing the local temperature. • The assisted Ar ion will influence the growth mode with the change of surface atom mobility. • The Volmer-Weber (island) growth mode is inhibited with a high assisted Ar ion energy. - Abstract: This paper has investigated the impact of the substrate temperature and Ar ion assisted deposition on the surface structure formation mechanism and the film properties during the amorphous TiO{sub 2} thin film deposition process with the molecular dynamics simulation method. The results show that the reduction of the surface roughness happen when the energy of Ar ions assisted is increased or the substrate temperature rises, and also the film density on surface is changed with the increasing of Ar ions energy and substrate temperature. It is also found that the Volmer-Weber (island) growth mode of films is promoted by the lower Ar ion energy and higher substrate temperature when the substrate has an island structure. The assisted Ar ion has power of making a flat surface and increasing the local temperature. Besides, it will influence the growth mode with the change of surface atom mobility. With a high assisted Ar ion energy the Volmer-Weber (island) growth mode is inhibited, which will be conducive to the formation of more smooth film surface.

  12. 40Ar/39Ar ages of adularia from the Golden Cross, Neavesville, and Komata epithermal deposits, Hauraki Goldfield, New Zealand

    International Nuclear Information System (INIS)

    Mauk, J.L.; Hall, C.M.

    2004-01-01

    New 40 Ar/ 39 Ar ages of adularia from three epithermal vein deposits in the Hauraki Goldfield constrain when these deposits formed. Adularia from veins at Neavesville has 40 Ar/ 39 Ar plateau and isochron ages of 6.89 ± 0.02 and 6.86 ± 0.02 Ma, respectively, similar to the 40 Ar/ 39 Ar plateau and isochron ages of adularia from veins at Golden Cross of 6.96 ± 0.04 and 6.93 ± 0.03 Ma, respectively. In contrast, Komata mineralisation formed at 5.99 ± 0.02 to 6.07 ± 0.03 Ma, based on the 40 Ar/ 39 Ar isochron and plateau ages of the adularia in these veins, similar to the previously reported 6.0 Ma age of mineralisation at Waihi/Favona. These preliminary data suggest that mineralisation in the Hauraki Goldfields occurred episodically. (author). 19 refs., 3 figs., 1 tab

  13. Predicting occupational personality test scores.

    Science.gov (United States)

    Furnham, A; Drakeley, R

    2000-01-01

    The relationship between students' actual test scores and their self-estimated scores on the Hogan Personality Inventory (HPI; R. Hogan & J. Hogan, 1992), an omnibus personality questionnaire, was examined. Despite being given descriptive statistics and explanations of each of the dimensions measured, the students tended to overestimate their scores; yet all correlations between actual and estimated scores were positive and significant. Correlations between self-estimates and actual test scores were highest for sociability, ambition, and adjustment (r = .62 to r = .67). The results are discussed in terms of employers' use and abuse of personality assessment for job recruitment.

  14. Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer.

    Science.gov (United States)

    Scher, Howard I; Graf, Ryon P; Schreiber, Nicole A; McLaughlin, Brigit; Lu, David; Louw, Jessica; Danila, Daniel C; Dugan, Lyndsey; Johnson, Ann; Heller, Glenn; Fleisher, Martin; Dittamore, Ryan

    2017-06-01

    Circulating tumor cells (CTCs) expressing AR-V7 protein localized to the nucleus (nuclear-specific) identify metastatic castration-resistant prostate cancer (mCRPC) patients with improved overall survival (OS) on taxane therapy relative to the androgen receptor signaling inhibitors (ARSi) abiraterone acetate, enzalutamide, and apalutamide. To evaluate if expanding the positivity criteria to include both nuclear and cytoplasmic AR-V7 localization ("nuclear-agnostic") identifies more patients who would benefit from a taxane over an ARSi. The study used a cross-sectional cohort. Between December 2012 and March 2015, 193 pretherapy blood samples, 191 of which were evaluable, were collected and processed from 161 unique mCRPC patients before starting a new line of systemic therapy for disease progression at the Memorial Sloan Kettering Cancer Center. The association between two AR-V7 scoring criteria, post-therapy prostate-specific antigen (PSA) change (PTPC) and OS following ARSi or taxane treatment, was explored. One criterion required nuclear-specific AR-V7 localization, and the other required an AR-V7 signal but was agnostic to protein localization in CTCs. Correlation of AR-V7 status to PTPC and OS was investigated. Relationships with survival were analyzed using multivariable Cox regression and log-rank analyses. A total of 34 (18%) samples were AR-V7-positive using nuclear-specific criteria, and 56 (29%) were AR-V7-positive using nuclear-agnostic criteria. Following ARSi treatment, none of the 16 nuclear-specific AR-V7-positive samples and six of the 32 (19%) nuclear-agnostic AR-V7-positive samples had ≥50% PTPC at 12 weeks. The strongest baseline factor influencing OS was the interaction between the presence of nuclear-specific AR-V7-positive CTCs and treatment with a taxane (hazard ratio 0.24, 95% confidence interval 0.078-0.79; p=0.019). This interaction was not significant when nuclear-agnostic criteria were used. To reliably inform treatment selection

  15. Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.

    Science.gov (United States)

    Kohli, Manish; Ho, Yeung; Hillman, David W; Van Etten, Jamie L; Henzler, Christine; Yang, Rendong; Sperger, Jamie M; Li, Yingming; Tseng, Elizabeth; Hon, Ting; Clark, Tyson; Tan, Winston; Carlson, Rachel E; Wang, Liguo; Sicotte, Hugues; Thai, Ho; Jimenez, Rafael; Huang, Haojie; Vedell, Peter T; Eckloff, Bruce W; Quevedo, Jorge F; Pitot, Henry C; Costello, Brian A; Jen, Jin; Wieben, Eric D; Silverstein, Kevin A T; Lang, Joshua M; Wang, Liewei; Dehm, Scott M

    2017-08-15

    Purpose: Androgen receptor (AR) variant AR-V7 is a ligand-independent transcription factor that promotes prostate cancer resistance to AR-targeted therapies. Accordingly, efforts are under way to develop strategies for monitoring and inhibiting AR-V7 in castration-resistant prostate cancer (CRPC). The purpose of this study was to understand whether other AR variants may be coexpressed with AR-V7 and promote resistance to AR-targeted therapies. Experimental Design: We utilized complementary short- and long-read sequencing of intact AR mRNA isoforms to characterize AR expression in CRPC models. Coexpression of AR-V7 and AR-V9 mRNA in CRPC metastases and circulating tumor cells was assessed by RNA-seq and RT-PCR, respectively. Expression of AR-V9 protein in CRPC models was evaluated with polyclonal antisera. Multivariate analysis was performed to test whether AR variant mRNA expression in metastatic tissues was associated with a 12-week progression-free survival endpoint in a prospective clinical trial of 78 CRPC-stage patients initiating therapy with the androgen synthesis inhibitor, abiraterone acetate. Results: AR-V9 was frequently coexpressed with AR-V7. Both AR variant species were found to share a common 3' terminal cryptic exon, which rendered AR-V9 susceptible to experimental manipulations that were previously thought to target AR-V7 uniquely. AR-V9 promoted ligand-independent growth of prostate cancer cells. High AR-V9 mRNA expression in CRPC metastases was predictive of primary resistance to abiraterone acetate (HR = 4.0; 95% confidence interval, 1.31-12.2; P = 0.02). Conclusions: AR-V9 may be an important component of therapeutic resistance in CRPC. Clin Cancer Res; 23(16); 4704-15. ©2017 AACR . ©2017 American Association for Cancer Research.

  16. Differences of wells scores accuracy, caprini scores and padua scores in deep vein thrombosis diagnosis

    Science.gov (United States)

    Gatot, D.; Mardia, A. I.

    2018-03-01

    Deep Vein Thrombosis (DVT) is the venous thrombus in lower limbs. Diagnosis is by using venography or ultrasound compression. However, these examinations are not available yet in some health facilities. Therefore many scoring systems are developed for the diagnosis of DVT. The scoring method is practical and safe to use in addition to efficacy, and effectiveness in terms of treatment and costs. The existing scoring systems are wells, caprini and padua score. There have been many studies comparing the accuracy of this score but not in Medan. Therefore, we are interested in comparative research of wells, capriniand padua score in Medan.An observational, analytical, case-control study was conducted to perform diagnostic tests on the wells, caprini and padua score to predict the risk of DVT. The study was at H. Adam Malik Hospital in Medan.From a total of 72 subjects, 39 people (54.2%) are men and the mean age are 53.14 years. Wells score, caprini score and padua score has a sensitivity of 80.6%; 61.1%, 50% respectively; specificity of 80.65; 66.7%; 75% respectively, and accuracy of 87.5%; 64.3%; 65.7% respectively.Wells score has better sensitivity, specificity and accuracy than caprini and padua score in diagnosing DVT.

  17. Medium-Index Mixed-Oxide Layers for Use in AR-Coatings

    Science.gov (United States)

    Ganner, Peter

    1986-10-01

    Ttedesign philosophy of MC-AR-Coatings can be divided into two categories: a) Restriction to two film materials, namely one high-index and one low-index material and b) Use of medium-index layers in addition to high- and low-index layers. Both philosophies have advan-tages and drawbacks. In case a) the total number of layers necessary to obtain a required reflectance curve has to be higher. Thus in case of production errors it can be a problem to find out which layer was responsible for a deviation of the measured reflectance from the nominal one. In case b) using more than two materials reduces the total number of layers and consequently, pinpointing the cause of even small production errors is made simpler. Unfortunately there are not many materials commercially available which can be used to make hard, durable and robust films in the medium-index range namely between n=1.65 and n=2.00. In this paper the results of homogeneous mixtures of Alumina (Al203) and Tantala (Ta205) used for EB-gun evaporated medium-index films in AR-coatings is presented. It is shown that by proper adjustment of the weight percentages of the oxide mixture one can get homogeneous films in this index range. A number of design examples show the favourable application of such layers in AR-coatings. Among the most important ones is the well known QHQ-design for BBAR-coatings as well as AR-designs of the multiple half wave type with extended bandwidth. Further applications of the mixed-oxide layers are AR-coatings for cemented optical elements and beam splitters.

  18. AR mutations in 28 patients with androgen insensitivity syndrome (Prader grade 0-3).

    Science.gov (United States)

    Wang, Yi; Gong, Chunxiu; Wang, Xiou; Qin, Miao

    2017-07-01

    We investigated the androgen receptor (AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome (AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes (Prader grade 0-3). Patients and some family members were screened via amplification and sequencing of their AR exons 1-8, including the corresponding intronic flanking regions. Luteinizing (LH), follicle-stimulating (FSH), and testosterone (T) hormone levels were found to be slightly, but not significantly, higher in patients with complete androgen insensitivity syndrome (CAIS) than in patients with partial androgen insensitivity syndrome (PAIS) (P>0.05). We identified 24 different AR mutations, including 12 that were novel. Ten patients (cases 2, 3, 10, 28, 11, 12, 19, 20, 24, and 25) were found to carry five recurrent mutations (p.Y572S, p.P914S, p.S176R, p.Y782N, and p.R841H); of these, p.Y572S, p.S176R, and p.Y782N were novel. Among the mutations identified in patients with CAIS, six (66.7%) were characterized as single-nucleotide missense mutations, and six (66.7%) were found to be located in the AR ligand-binding domain (LBD). Among the mutations identified in patients with PAIS, 15 (93.8%) were found to be missense, and 11 (68.8%) were found to be located in the LBD. Patients 10 and 28 were determined to harbor the same missense mutation (p.P914S), but were diagnosed with CAIS and PAIS, respectively. Sex hormone levels were slightly, but not significantly, elevated in patients with CAIS compared to those with PAIS. Missense mutations spanning AR exons 1-8 were the predominant form of identified mutations, and these were mostly located in the AR LBD. Approximately 50% of the identified mutations were novel, and have enriched the AR gene-mutation database. Patients harboring identical mutations were in some instances found to exhibit divergent phenotypes.

  19. Ar-40/Ar-39 age determinations for the Rotoiti eruption, New Zealand

    Science.gov (United States)

    Flude, S.; Storey, M.

    2013-12-01

    The contemporaneous Rotoiti and Earthquake Flat ignimbrites, erupted from the Taupo Volcanic zone, New Zealand, form a distinctive tephrostratigraphic horizon in the Southern Pacific. Radioisotopic dating results for these eruptions remain controversial, with published ages ranging from 35.1 × 2.8 ka [1] to 71 × 6 ka [2], with 61.0 × 1.5 ka [3] often being cited as the most widely accepted age. These eruptions are difficult to date as their age is near the limit for various radiometric dating techniques, which are complicated by a large proportion of inherited material (xenocrysts) and a lack of phases suitable for dating. Glass-bearing plutonic blocks erupted with the Rotoiti and Earthquake Flat ignimbrites have previously been interpreted as deriving from a slowly cooled and incompletely solidified magma body that was sampled by the eruptions. They contain large vugs lined with euhedral quartz, sanidine and biotite crystals, indicating that these crystals grew in a gas or aqueous fluid rich environment and are interpreted to have formed shortly before or during eruption. Here we will present Ar-40/Ar-39 ages for sanidines and biotites extracted from vugs in lithic blocks erupted as part of the Earthquake Flat ignimbrite. We show that, even for vug-lining material, inherited ages remain a problem and are the likely source of the wide variation in published radiometric ages. Nevertheless, many of the Ar-40/Ar-39 ages are much younger than the 61 ka age [3] and are more consistent with the recent stratigraphic, C-14 and U-238/Th-230+(U-Th)/He ages that have been suggested (e.g. [4,5]). 1. Whitehead, N. & Ditchburn, R. New Zealand Journal of Geology and Geophysics 37, 381-383 (1994). 2. Ota, Y., Omura, A. & Iwata, H. New Zealand Journal of Geology and Geophysics 32, 327-331 (1989). 3. Wilson, C. J. N. et al. Quaternary Science Reviews 26, 1861-1870 (2007). 4. Molloy, C., Shane, P. & Augustinus, P. Geological Society of America Bulletin 121, 1666-1677 (2009). 5

  20. AR Signaling in Human Malignancies: Prostate Cancer and Beyond.

    Science.gov (United States)

    Antonarakis, Emmanuel S

    2018-01-18

    The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This special issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.

  1. The development of AR book for computer learning

    Science.gov (United States)

    Phadung, Muneeroh; Wani, Najela; Tongmnee, Nur-aiynee

    2017-08-01

    Educators need to provide the alternative educational tools to foster learning outcomes of students. By using AR technology to create exciting edutainment experiences, this paper presents how augmented reality (AR) can be applied in the education. This study aims to develop the AR book for tenth grade students (age 15-16) and evaluate its quality. The AR book was developed based on ADDIE framework processes to provide computer learning on software computer knowledge. The content was accorded with the current Thai education curriculum. The AR book had 10 pages in three topics (the first was "Introduction," the second was "System Software" and the third was "Application Software"). Each page contained markers that placed virtual objects (2D animation and video clip). The obtained data were analyzed in terms of average and standard deviation. The validity of multimedia design of the AR book was assessed by three experts in multimedia design. A five-point Likert scale was used and the values were X¯ =4 .84 , S.D. = 1.27 which referred to very high. Moreover, three content experts, who specialize in computer teaching, evaluated the AR book's validity. The values determined by the experts were X¯ =4 .69 , S.D. = 0.29 which referred to very high. Implications for future study and education are discussed.

  2. Developing a chronostratigraphic tool for climatic archives: absolute dating (K/Ar and 40Ar/39Ar) and paleo-magnetism applied to lavas

    International Nuclear Information System (INIS)

    Sasco, Romain

    2015-01-01

    The understanding of climatic mechanisms and rapid climate changes requires a high-resolution, robust, and precise timescale which allows long-distance and multi-archives correlations.An appropriate tool to construct such a timescale is provided by the Earth magnetic field (EMF). The EMF is independent from climatic variations and its past evolution, global at the surface of the Earth, is recorded by most of the geological/climatic archives. Sedimentary sequences provide continuous records of relative intensities of the EMF on timescales usually based on ice core age models or orbital tuning. Lavas, though discontinuously emitted through time, record the absolute intensity of the EMF during their cooling at the surface of the Earth. Lavas are dated using 2 complementary methods: 40 Ar/ 39 Ar and K-Ar, both independent from climatic parameters. Lavas have therefore the potential to deliver tie-points (age - paleo-intensity couples) enabling the time calibration of sedimentary sequences and their transfer onto absolute intensity scale and chronological time scale. This timescale can then be transferred to other climatic archives. The present study focusses on the last 200 ka with lavas sampled from young volcanoes of Ardeche (South Massif Central, France) and recent phases of volcanism in the Canary Islands. Lava flows from Ardeche provided un-exploitable paleo-intensity results and ages with large uncertainties. Therefore, they failed to provide suitable tie-points. However, our geochronological results evidence how crucial the combination of both the K-Ar and 40 Ar/ 39 Ar methods is to test the accuracy and geological meaning of the ages. Ardeche lavas have abundant mantellic and crustal xenoliths, potential carriers of excess 40 Ar*. Our study suggests that the argon excess is located in sites that decrepitate at low temperature (≤600 C). Because 40 Ar/ 39 Ar ages are not affected by excess 40 Ar*, they provide reliable results. The new age dataset indicates

  3. Thermal significance of potassium feldspar K-Ar ages inferred from /sup 40/Ar//sup 39/Ar age spectrum results

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, T.M.; McDougall, I. (Australian National Univ., Canberra. Research School of Earth Sciences)

    1982-10-01

    /sup 40/Ar//sup 39/Ar age spectrum analyses of three microcline separates from the Separation Point Batholith, northwest Nelson, New Zealand, which cooled slowly through the temperature zone of partial radiogenic /sup 40/Ar accumulation are characterized by a linear age increase over the first 65 percent of gas release with the lowest ages corresponding to the time that the samples cooled below about 100/sup 0/C. The last 35 percent of /sup 39/Ar released from the microclines yields plateau ages which reflect the different bulk mineral ages, and correspond to cooling temperatures between about 130 to 160/sup 0/C. Theoretical calculations confirm the likelihood of diffusion gradients in feldspars cooling at rates =< 5/sup 0/C-Ma/sup -1/. Diffusion parameters calculated from the /sup 39/Ar release yield an activation energy, E = 28.8 +- 1.9 kcal-mol/sup -1/, and a frequency factor/grain size parameter, D/sub 0//l/sup 2/ = 5.6sub(-3.9)sup(+14) sec/sup -1/. This Arrhenius relationship corresponds to a closure temperature of 132 +- 13/sup 0/C which is very similar to the independently estimated temperature. From the observed diffusion compensation correlation, this D/sub 0//l/sup 2/ implies an average diffusion half-width of about 3 ..mu..m, similar to the half-width of the perthite lamellae in the feldspars. The results are discussed.

  4. Cross Sections and Transport Properties of BR- Ions in AR

    Science.gov (United States)

    Jovanovic, Jasmina; Stojanovic, Vladimir; Raspopovic, Zoran; Petrovic, Zoran

    2014-10-01

    We have used a combination of a simple semi-analytic theory - Momentum Transfer Theory (MTT) and exact Monte Carlo (MC) simulations to develop Br- in Ar momentum transfer cross section based on the available data for reduced mobility at the temperature T = 300 K over the range 10 Td higher energies based on behavior of similar ions in similar gases and by the addition of the total detachment cross section that was used from the threshold around 7.7 eV. Relatively complete set was derived which can be used in modeling of plasmas by both hybrid, particle in cell (PIC) and fluid codes. A good agreement between calculated and measured ion mobilities and longitudinal diffusion coefficients is an independent proof of the validity of the cross sections that were derived for the negative ion mobility data. In addition to transport coefficients we have also calculated the net rate coefficients of elastic scattering and detachment. Author acknowledge Ministry of Education, Science and Technology, Proj. Nos. 171037 and 410011.

  5. 40Ar/ 39Ar dating of Late Permian evaporites, southeastern New Mexico, USA

    Science.gov (United States)

    Renne, Paul R.; Sharp, Warren D.; Montañez, Isabel P.; Becker, Tim A.; Zierenberg, Robert A.

    2001-12-01

    40Ar/ 39Ar dating of the potassium-magnesium sulfate mineral langbeinite from Permian evaporites of the Salado formation near Carlsbad, New Mexico, provides quantitative evidence that some salts in these deposits have not recrystallized for 251 Myr since deposition. Survival of Permian salts supports the possibility that Bacillus bacteria recovered from nearby halite was isolated in a closed system and represents a sample of uncontaminated Permian life. Local recrystallization of langbeinite and other nearby minerals is also indicated by the dating, suggesting both the need and the opportunity to document closed system behavior more rigorously. The shoaling and desiccation event recorded by the Salado formation began at least 1 Myr before the Permian-Triassic boundary. Temporal correlation of the Salado with the Zechstein evaporites of north-central Europe supports previously inferred regression models for the origin of these deposits. Significant paleoenvironmental change at the Permian-Triassic boundary thus occurred on a time scale more protracted than that implied by geologically instantaneous events such as bolide impacts.

  6. The 40Ar/39Ar age spectrum of a rock from Gerrans Bay, Cornwall

    International Nuclear Information System (INIS)

    Fitch, F.J.; Forster, S.C.; Miller, J.A.

    1984-01-01

    The results of the 40 Ar/ 39 Ar step heating study of a folded and cleaved metasiltstone are presented. The rock comes from the melange of the Roseland area, NE of the Lizard. The age spectrum obtained has two distinct sectors: (i) an older age component giving apparent ages of 521 to 490 Ma and (ii) a younger component with an apparent age of 424 to 410 Ma. The petrography suggests that the former is derived from the more resistant parts of large detrital muscovite flakes, while the latter comes from smaller metamorphic micas aligned along the prominent cleavage and also, in part, from original detrital grains partially or totally overprinted during the metamorphic event. The sediment was probably mid-to late-Ordovician in age. The source rocks appear to have been very largely of late Cambrian/early Arenig age. Folding, age and low-grade regional metamorphism occurred as a result of late Caledonian orogenesis between 424 to 410 Ma. There is no evidence of any Variscan overprint on the age spectrum. Very minor, low energy argon losses appear to have taken place in mid-Mesozoic times but, apart from this, the absence of any major overprint younger than 410 Ma indicates that since the end of the Silurian the rock has suffered only high-level, cold, non-penetrative deformation. (author)

  7. 40Ar/39Ar dating and geochemistry of tholeiitic magmatism related to the early opening of the Central Atlantic rift

    International Nuclear Information System (INIS)

    Sebai, A.; Feraud, G.; Bertrand, H.; Hanes, J.

    1991-01-01

    Tholeiitic effusive and intrusive magnetism from Iberia, Morocco, Algeria and Mali, realted to the early opening of the Central Atlantic rift, was dated by the 40 Ar/ 39 Ar step-heating method. Four plateau ags, rangin from 203.7±2.7 to 197.1±1.8 Ma, were obtained on plagioclase from dykes from theTaoudenni area (Mali) and two lava flows from Morocco. The Messejana dyke (Iberia), which previously yielded discrepant conventional K-Ar dates, did not furnish any 40 Ar/ 39 Ar plateau dates. However, there is a clear inverse relationship between apparent age and K/Ca atio for gas fractions from a plagioclase separate (proportional to the alteration degree) which, combined with dates obtained on amphibole, biotite and pyroxene, allows us to determine an age of around 200 Ma for this body. These data, and those obtained on the Foum Zguid (Morocco) and the Ksi Ksou (Algeria) dykes, give evidence of a brief magmatic event (between 206 and 195 Ma ago) which affected a large area ca. 2500 km long. Trace-element modelling shows that most of these formations originated from a homogeneous, enriched, source material. Such a brief magmatic episode related to the opening of a continental rift is in agreement with findings in other magmatic provinces (e.g. the Deccan traps and the Red Sea rift, precisely dated by the 40 Ar/ 39 Ar method as well). (orig.)

  8. [Propensity score matching in SPSS].

    Science.gov (United States)

    Huang, Fuqiang; DU, Chunlin; Sun, Menghui; Ning, Bing; Luo, Ying; An, Shengli

    2015-11-01

    To realize propensity score matching in PS Matching module of SPSS and interpret the analysis results. The R software and plug-in that could link with the corresponding versions of SPSS and propensity score matching package were installed. A PS matching module was added in the SPSS interface, and its use was demonstrated with test data. Score estimation and nearest neighbor matching was achieved with the PS matching module, and the results of qualitative and quantitative statistical description and evaluation were presented in the form of a graph matching. Propensity score matching can be accomplished conveniently using SPSS software.

  9. [Prognostic scores for pulmonary embolism].

    Science.gov (United States)

    Junod, Alain

    2016-03-23

    Nine prognostic scores for pulmonary embolism (PE), based on retrospective and prospective studies, published between 2000 and 2014, have been analyzed and compared. Most of them aim at identifying PE cases with a low risk to validate their ambulatory care. Important differences in the considered outcomes: global mortality, PE-specific mortality, other complications, sizes of low risk groups, exist between these scores. The most popular score appears to be the PESI and its simplified version. Few good quality studies have tested the applicability of these scores to PE outpatient care, although this approach tends to already generalize in the medical practice.

  10. Single-crystal 40Ar/39Ar incremental heating reveals bimodal sanidine ages in the Bishop Tuff

    Science.gov (United States)

    Andersen, N. L.; Jicha, B. R.; Singer, B. S.

    2015-12-01

    The 650 km3 Bishop Tuff (BT) is among the most studied volcanic deposits because it is an extensive marker bed deposited just after the Matuyama-Brunhes boundary. Reconstructions of the vast BT magma reservoir from which high-silica rhyolite erupted have long influenced thinking about how large silicic magma systems are assembled, crystallized, and mixed. Yet, the longevity of the high silica rhyolitic melt and exact timing of the eruption remain controversial due to recent conflicting 40Ar/39Ar sanidine vs. SIMS and ID-TIMS U-Pb zircon dates. We have undertaken 21 40Ar/39Ar incremental heating ages on 2 mm BT sanidine crystals from pumice in 3 widely separated outcrops of early-erupted fall and flow units. Plateau ages yield a bimodal distribution: a younger group has a mean of 766 ka and an older group gives a range between 772 and 782 ka. The younger population is concordant with the youngest ID-TIMS and SIMS U-Pb zircon ages recently published, as well as the astronomical age of BT in marine sediment. Of 21 crystals, 17 yield older, non-plateau, steps likely affected by excess Ar that would bias traditional 40Ar/39Ar total crystal fusion ages. The small spread in older sanidine ages, together with 25+ kyr of pre-eruptive zircon growth, suggest that the older sanidines are not partially outgassed xenocrysts. A bimodal 40Ar/39Ar age distribution implies that some fraction of rhyolitic melt cooled below the Ar closure temperature at least 10 ky prior to eruption. We propose that rapid "thawing" of a crystalline mush layer released older crystals into rhyolitic melt from which sanidine also nucleated and grew immediately prior to the eruption. High precision 40Ar/39Ar dating can thus provide essential information on thermo-physical processes at the millenial time scale that are critical to interpreting U-Pb zircon age distributions that are complicated by large uncertainties associated with zircon-melt U-Th systematics.

  11. The beta decay asymmetry parameter of 35Ar

    International Nuclear Information System (INIS)

    Garnett, J.D.

    1987-11-01

    The beta decay asymmetry parameter for 35 Ar = 35 Cl + e + + nu/sub e/ has been remeasured in order to resolve a long standing puzzle. Previous asymmetry measurements, when combined with the comparative half-life, yield a value for the vector coupling constant, G/sub v/, that is in serious disagreement with the accepted value. We produced polarized 35 Ar by a (p,n) reaction on 35 Cl using the polarized proton beam provided by Lawrence Berkeley Laboratory's 88-Inch Cyclotron. The polarization of the 35 Ar was determined by measuring the asymmetry of the positrons produced in 35 Ar decay to the first excited state in 35 Cl (branching ratio = 1.3%) in coincidence with a 1219.4 keV gamma ray. Our result, A 0 = 0.49 +- 0.10, combined with the comparative half-life yields a value for G/sub v/ in agreement with the accepted value

  12. Irradiation effects of Ar cluster ion beams on Si substrates

    International Nuclear Information System (INIS)

    Ishii, Masahiro; Sugahara, Gaku; Takaoka, G.H.; Yamada, Isao

    1993-01-01

    Gas-cluster ion beams can be applied to new surface modification techniques such as surface cleaning, low damage sputtering and shallow junction formation. The effects of energetic Ar cluster impacts on solid surface were studied for cluster energies of 10-30keV. Irradiation effects were studied by RBS. For Si(111) substrates, irradiated with Ar ≥500 clusters to a dose of 1x10 15 ion/cm 2 at acceleration voltage 15kV, 2x10 14 atoms/cm 2 implanted Ar atoms were detected. In this case, the energy per cluster atom was smaller than 30eV; at this energy, no significant implantation occurs in the case of monomer ions. Ar cluster implantation into Si substrates occurred due to the high energy density irradiation. (author)

  13. RadNet Air Data From Little Rock, AR

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Little Rock, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  14. RadNet Air Data From Fort Smith, AR

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Fort Smith, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  15. Numerical simualtion of underground 37Ar transportation to the ground

    International Nuclear Information System (INIS)

    She Ruogu; Li Hua; Liu Cheng'an; Wu Jun

    2008-01-01

    Monitoring radioactive gas 37 Ar is an important technique for the On-Site Inspection(OSI) of the Comprehensive Nuclear Test Ban Treaty (CTBT) verification regime. In order to establish a theoretical model that can be used to calculate the appearing time and radioactivity of 37 Ar which transports to the ground after a nuclear explosion, the rock media in the test area is assumed to be a homogeneous porous media, without consideration of gas absorption by and release from the rock media. The seepage model in the porous media is used to calculate 37 Ar transportation. Computational results give the time 37 Ar leaks to the ground and the variation of its radioactivity with time. And we can analyze and consider the computational results when we have developed OSI noble gas monitoring systems and evaluated their effectiveness. (authors)

  16. Potential hydroxyl ultraviolet laser. [Ar-H/sub 2/O

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C H; Payne, M G

    1976-09-01

    A strong emission band extending from 3060 to 3120 A was observed following proton beam excitation of an Ar--H/sub 2/O mixture. This emission band was assigned to the transition of OH(A/sup 2/Sigma/sup +/)/sub nu=o/ ..-->.. OH(X/sup 2/Pi)/sub nu=o/. At high argon partial pressure (> 200 torr), the precursor of this emission band is believed to be the argon excimer Ar/sup *//sub 2/(1/sub u/). The fluorescence efficiency of Ar--H/sub 2/O is estimated to be a factor of 4 times that of Ar--N/sub 2/. Development of a highly efficient, tunable uv laser by e-beam pumping is promising.

  17. Ar Rahman-Based Dysmenorrhea Gymnastic to Reduce Pain

    OpenAIRE

    Sumaryani, Sri; Puspita Sari, Praditiana Indah

    2015-01-01

    Introduction: More than 50% dysmenorrhea are caused by excessive amounts of prostaglandin hormone during menstruation.  The combination of dysmenorrhea gymnastics and Qur'an Surah Ar-Rahman relaxation techniques is a new innovation in non-pharmacological therapy to overcome dysmenorrhoea. The purpose of this study was to determine the level of pain differences on respondents who were given dysmenorrhea gymnastics treatment, Al Quran Surah Ar-Rahman recitation, and dysmenorrhea gymnastics comb...

  18. Low energy total cross section of 36Ar

    International Nuclear Information System (INIS)

    Mughabghab, S.F.; Magurno, B.A.

    1975-01-01

    To compare the predictions of the valence model with measured partial radiative widths of 36 Ar an accurate knowledge of the bound-level parameters is required. This is achieved by carrying out a Breit-Wigner parameter fit to the total cross section of 36 Ar measured by Chrien et al and renormalized to the recommended values of the thermal capture and scattering cross sections. (1 figure, 1 table) (U.S.)

  19. Strategic Repositioning for Convection Business Case Study: AR Vendor

    OpenAIRE

    Anindita, Pratisara Satwika; Toha, Mohamad

    2013-01-01

    The study aims to determine suitable position and strategy in order to reach superiority in convection business based on the company strengths and weaknesses. A study conducted in late 2012 at AR Vendor, a home-based convection company which focus on the t-shirt screen printing service. In response to the issue of the below average profit margin, the company has to rethink their position and strategy in handling the convection business environment. While AR Vendor business may growth in accor...

  20. An analysis of the 1977 AD/AR TARSLL.

    OpenAIRE

    Hargrove, James Wiley Jr.

    1980-01-01

    Approved for public release; distribution is unlimited The industrial mission of Destroyer Tenders (AD) and Repair Ships (AR) is to provide intermediate level maintenance and repair for supported ships. The Tender and Repair Ship Load List for these ships (AD/AR TARSLL) designates the range (number) and depth (quantity) of repair parts to be carried to support this industrial mission. This thesis details the logical reasoning and mathematical theory used to develop the...

  1. Nursing Activities Score and Acute Kidney Injury

    Directory of Open Access Journals (Sweden)

    Filipe Utuari de Andrade Coelho

    Full Text Available ABSTRACT Objective: to evaluate the nursing workload in intensive care patients with acute kidney injury (AKI. Method: A quantitative study, conducted in an intensive care unit, from April to August of 2015. The Nursing Activities Score (NAS and Kidney Disease Improving Global Outcomes (KDIGO were used to measure nursing workload and to classify the stage of AKI, respectively. Results: A total of 190 patients were included. Patients who developed AKI (44.2% had higher NAS when compared to those without AKI (43.7% vs 40.7%, p <0.001. Patients with stage 1, 2 and 3 AKI showed higher NAS than those without AKI. A relationship was identified between stage 2 and 3 with those without AKI (p = 0.002 and p <0.001. Conclusion: The NAS was associated with the presence of AKI, the score increased with the progression of the stages, and it was associated with AKI, stage 2 and 3.

  2. D-score: a search engine independent MD-score.

    Science.gov (United States)

    Vaudel, Marc; Breiter, Daniela; Beck, Florian; Rahnenführer, Jörg; Martens, Lennart; Zahedi, René P

    2013-03-01

    While peptides carrying PTMs are routinely identified in gel-free MS, the localization of the PTMs onto the peptide sequences remains challenging. Search engine scores of secondary peptide matches have been used in different approaches in order to infer the quality of site inference, by penalizing the localization whenever the search engine similarly scored two candidate peptides with different site assignments. In the present work, we show how the estimation of posterior error probabilities for peptide candidates allows the estimation of a PTM score called the D-score, for multiple search engine studies. We demonstrate the applicability of this score to three popular search engines: Mascot, OMSSA, and X!Tandem, and evaluate its performance using an already published high resolution data set of synthetic phosphopeptides. For those peptides with phosphorylation site inference uncertainty, the number of spectrum matches with correctly localized phosphorylation increased by up to 25.7% when compared to using Mascot alone, although the actual increase depended on the fragmentation method used. Since this method relies only on search engine scores, it can be readily applied to the scoring of the localization of virtually any modification at no additional experimental or in silico cost. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Trends in Classroom Observation Scores

    Science.gov (United States)

    Casabianca, Jodi M.; Lockwood, J. R.; McCaffrey, Daniel F.

    2015-01-01

    Observations and ratings of classroom teaching and interactions collected over time are susceptible to trends in both the quality of instruction and rater behavior. These trends have potential implications for inferences about teaching and for study design. We use scores on the Classroom Assessment Scoring System-Secondary (CLASS-S) protocol from…

  4. Quadratic prediction of factor scores

    NARCIS (Netherlands)

    Wansbeek, T

    1999-01-01

    Factor scores are naturally predicted by means of their conditional expectation given the indicators y. Under normality this expectation is linear in y but in general it is an unknown function of y. II is discussed that under nonnormality factor scores can be more precisely predicted by a quadratic

  5. The Machine Scoring of Writing

    Science.gov (United States)

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  6. Matching score based face recognition

    NARCIS (Netherlands)

    Boom, B.J.; Beumer, G.M.; Spreeuwers, Lieuwe Jan; Veldhuis, Raymond N.J.

    2006-01-01

    Accurate face registration is of vital importance to the performance of a face recognition algorithm. We propose a new method: matching score based face registration, which searches for optimal alignment by maximizing the matching score output of a classifier as a function of the different

  7. Modelling sequentially scored item responses

    NARCIS (Netherlands)

    Akkermans, W.

    2000-01-01

    The sequential model can be used to describe the variable resulting from a sequential scoring process. In this paper two more item response models are investigated with respect to their suitability for sequential scoring: the partial credit model and the graded response model. The investigation is

  8. Combined U-Th/He and 40Ar/39Ar geochronology of post-shield lavas from the Mauna Kea and Kohala volcanoes, Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Aciego, S.M.; Jourdan, F.; DePaolo, D.J.; Kennedy, B.M.; Renne, P.R.; Sims, K.W.W.

    2009-10-01

    Late Quaternary, post-shield lavas from the Mauna Kea and Kohala volcanoes on the Big Island of Hawaii have been dated using the {sup 40}Ar/{sup 39}Ar and U-Th/He methods. The objective of the study is to compare the recently demonstrated U-Th/He age method, which uses basaltic olivine phenocrysts, with {sup 40}Ar/{sup 39}Ar ages measured on groundmass from the same samples. As a corollary, the age data also increase the precision of the chronology of volcanism on the Big Island. For the U-Th/He ages, U, Th and He concentrations and isotopes were measured to account for U-series disequilibrium and initial He. Single analyses U-Th/He ages for Hamakua lavas from Mauna Kea are 87 {+-} 40 ka to 119 {+-} 23 ka (2{sigma} uncertainties), which are in general equal to or younger than {sup 40}Ar/{sup 39}Ar ages. Basalt from the Polulu sequence on Kohala gives a U-Th/He age of 354 {+-} 54 ka and a {sup 40}Ar/{sup 39}Ar age of 450 {+-} 40 ka. All of the U-Th/He ages, and all but one spurious {sup 40}Ar/{sup 39}Ar ages conform to the previously proposed stratigraphy and published {sup 14}C and K-Ar ages. The ages also compare favorably to U-Th whole rock-olivine ages calculated from {sup 238}U - {sup 230}Th disequilibria. The U-Th/He and {sup 40}Ar/{sup 39}Ar results agree best where there is a relatively large amount of radiogenic {sup 40}Ar (>10%), and where the {sup 40}Ar/{sup 36}Ar intercept calculated from the Ar isochron diagram is close to the atmospheric value. In two cases, it is not clear why U-Th/He and {sup 40}Ar/{sup 39}Ar ages do not agree within uncertainty. U-Th/He and {sup 40}Ar/{sup 39}Ar results diverge the most on a low-K transitional tholeiitic basalt with abundant olivine. For the most alkalic basalts with negligible olivine phenocrysts, U-Th/He ages were unattainable while {sup 40}Ar/{sup 39}Ar results provide good precision even on ages as low as 19 {+-} 4 ka. Hence, the strengths and weaknesses of the U-Th/He and {sup 40}Ar/{sup 39}Ar methods are

  9. Heart valve surgery: EuroSCORE vs. EuroSCORE II vs. Society of Thoracic Surgeons score

    Directory of Open Access Journals (Sweden)

    Muhammad Sharoz Rabbani

    2014-12-01

    Full Text Available Background This is a validation study comparing the European System for Cardiac Operative Risk Evaluation (EuroSCORE II with the previous additive (AES and logistic EuroSCORE (LES and the Society of Thoracic Surgeons’ (STS risk prediction algorithm, for patients undergoing valve replacement with or without bypass in Pakistan. Patients and Methods Clinical data of 576 patients undergoing valve replacement surgery between 2006 and 2013 were retrospectively collected and individual expected risks of death were calculated by all four risk prediction algorithms. Performance of these risk algorithms was evaluated in terms of discrimination and calibration. Results There were 28 deaths (4.8% among 576 patients, which was lower than the predicted mortality of 5.16%, 6.96% and 4.94% by AES, LES and EuroSCORE II but was higher than 2.13% predicted by STS scoring system. For single and double valve replacement procedures, EuroSCORE II was the best predictor of mortality with highest Hosmer and Lemmeshow test (H-L p value (0.346 to 0.689 and area under the receiver operating characteristic (ROC curve (0.637 to 0.898. For valve plus concomitant coronary artery bypass grafting (CABG patients actual mortality was 1.88%. STS calculator came out to be the best predictor of mortality for this subgroup with H-L p value (0.480 to 0.884 and ROC (0.657 to 0.775. Conclusions For Pakistani population EuroSCORE II is an accurate predictor for individual operative risk in patients undergoing isolated valve surgery, whereas STS performs better in the valve plus CABG group.

  10. Use of an A.E.I. MS 10 mass spectrometer for 40Ar-39Ar dating

    International Nuclear Information System (INIS)

    Baksi, A.K.

    1979-01-01

    The use of an AEI mass spectrometer for 40 Ar/ 39 Ar dating could, in principle, be problematical due to its limited mass resolution and because of non-linear mass discrimination under certain operating conditions. These possible drawbacks have been investigated and are found to be easy to overcome. Tailing corrections are relatively small and can be applied precisely for 40 Ar/ 39 Ar ratios <= 300. By operating the instrument with a trap current of 50 μA and an ion repeller voltage of +1.0 w.r.t. cage, problems due to non-linear mass discrimination are eliminated. Using the incremental heating technique and total fusion studies on very small subsamples (10-25 mg.), the homogeneity of some well-known inter-laboratory standards has been investigated; the relative merits of these standards are discussed. (K.B.)

  11. Heterogeneous 40Ar/39Ar laser probe apparent ages in low-grade mylonitic rocks: Constraining a meaningful geological age

    International Nuclear Information System (INIS)

    Arancibia, G

    2001-01-01

    Obtaining meaningful geological ages from mylonitic rocks has been a major problem for structural geologist, because apparent ages have usually no geologic significance. Over the last years, in situ high spatial resolutions 40 Ar/ 39 Ar studies (e.g. Ruffet et al., 1991; Reddy et al., 1996; Pickles et al., 1997), permit obtain apparent ages of mineral and link them directly with textural, microstructural and chemical patterns that can previously be obtained by optical and scanning electron (SEM) microscopes and electron microprobe. In this work, heterogeneous 40 Ar/ 39 Ar laser probe ages from low-grade volcanic mylonites show complex argon distributions patterns. Inverse isochron analysis suggests that most obtained apparent ages contain argon excess and only younger ages have a meaningful geologically interpretation (au)

  12. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.

    Directory of Open Access Journals (Sweden)

    Tara K Sigdel

    Full Text Available Whole genome microarray meta-analyses of 1030 kidney, heart, lung and liver allograft biopsies identified a common immune response module (CRM of 11 genes that define acute rejection (AR across different engrafted tissues. We evaluated if the CRM genes can provide a molecular microscope to quantify graft injury in acute rejection (AR and predict risk of progressive interstitial fibrosis and tubular atrophy (IFTA in histologically normal kidney biopsies.Computational modeling was done on tissue qPCR based gene expression measurements for the 11 CRM genes in 146 independent renal allografts from 122 unique patients with AR (n = 54 and no-AR (n = 92. 24 demographically matched patients with no-AR had 6 and 24 month paired protocol biopsies; all had histologically normal 6 month biopsies, and 12 had evidence of progressive IFTA (pIFTA on their 24 month biopsies. Results were correlated with demographic, clinical and pathology variables.The 11 gene qPCR based tissue CRM score (tCRM was significantly increased in AR (5.68 ± 0.91 when compared to STA (1.29 ± 0.28; p < 0.001 and pIFTA (7.94 ± 2.278 versus 2.28 ± 0.66; p = 0.04, with greatest significance for CXCL9 and CXCL10 in AR (p <0.001 and CD6 (p<0.01, CXCL9 (p<0.05, and LCK (p<0.01 in pIFTA. tCRM was a significant independent correlate of biopsy confirmed AR (p < 0.001; AUC of 0.900; 95% CI = 0.705-903. Gene expression modeling of 6 month biopsies across 7/11 genes (CD6, INPP5D, ISG20, NKG7, PSMB9, RUNX3, and TAP1 significantly (p = 0.037 predicted the development of pIFTA at 24 months.Genome-wide tissue gene expression data mining has supported the development of a tCRM-qPCR based assay for evaluating graft immune inflammation. The tCRM score quantifies injury in AR and stratifies patients at increased risk of future pIFTA prior to any perturbation of graft function or histology.

  13. Acute costs and predictors of higher treatment costs of trauma in New South Wales, Australia.

    Science.gov (United States)

    Curtis, Kate; Lam, Mary; Mitchell, Rebecca; Black, Deborah; Taylor, Colman; Dickson, Cara; Jan, Stephen; Palmer, Cameron S; Langcake, Mary; Myburgh, John

    2014-01-01

    Accurate economic data are fundamental for improving current funding models and ultimately in promoting the efficient delivery of services. The financial burden of a high trauma casemix to designated trauma centres in Australia has not been previously determined, and there is some evidence that the episode funding model used in Australia results in the underfunding of trauma. To describe the costs of acute trauma admissions in trauma centres, identify predictors of higher treatment costs and cost variance in New South Wales (NSW), Australia. Data linkage of admitted trauma patient and financial data provided by 12 Level 1 NSW trauma centres for the 08/09 financial year was performed. Demographic, injury details and injury scores were obtained from trauma registries. Individual patient general ledger costs (actual trauma patient costs), Australian Refined Diagnostic Related Groups (AR-DRG) and state-wide average costs (which form the basis of funding) were obtained. The actual costs incurred by the hospital were then compared with the state-wide AR-DRG average costs. Multivariable multiple linear regression was used for identifying predictors of costs. There were 17,522 patients, the average per patient cost was $10,603 and the median was $4628 (interquartile range: $2179-10,148). The actual costs incurred by trauma centres were on average $134 per bed day above AR-DRG costs-determined costs. Falls, road trauma and violence were the highest causes of total cost. Motor cyclists and pedestrians had higher median costs than motor vehicle occupants. As a result of greater numbers, patients with minor injury had comparable total costs with those generated by patients with severe injury. However the median cost of severely injured patients was nearly four times greater. The count of body regions injured, sex, length of stay, serious traumatic brain injury and admission to the Intensive Care Unit were significantly associated with increased costs (p<0.001). This

  14. Characteristics and 40Ar/39Ar geochronology of the Erdenet Cu-Mo deposit, Mongolia

    Science.gov (United States)

    Kavalieris, Imants; Khashgerel, Bat-Erdene; Morgan, Leah; Undrakhtamir, Alexander; Borohul, Adiya

    2017-01-01

    50 to 200 m from the granodiorite porphyry contact, although D veins (and chalcopyrite) extend outward to the propylitic zone.The Erdenet porphyry system, was overprinted by advanced argillic alteration, which outcrops 2 km northwest of the pit, and forms a lithocap that extends over 10 × 2.5 km. It is characterized by residual quartz, andalusite, Na-Ca and K-alunite, diaspore, pyrophyllite, zunyite, topaz, dickite, and kaolinite. The upper part of the porphyry Cu-Mo deposit (removed by mining), comprised a bornite-chalcocite enriched zone up to 300 m thick with an average grade of 0.7 wt % Cu and up to 5 wt % Cu locally. Based on hypogene bornite-chalcocite mineral textures and high-sulfidation state mineralogy, the enriched zone is inferred to be of hypogene origin, but modified by supergene processes. Consequently, it may be related to formation of the lithocap.Previous Re-Os dates of 240.4 and 240.7 ± 0.8 Ma for molybdenite in quartz veins are comparable to new 40Ar/39Ar dates of 239.7 ± 1.6 and 240 ± 2 Ma for muscovite that envelops D veins. One 40Ar/39Ar date on K-alunite from the lithocap of 223.5 ± 1.9 Ma suggests that it may be about 16 m.y. younger than Erdenet, but this result needs to be verified by further dating.

  15. 40Ar/39Ar Dating of the Brunhes-Matuyama Geomagnetic Field Reversal.

    Science.gov (United States)

    Baksi, A K; Hsu, V; McWilliams, M O; Farrar, E

    1992-04-17

    Magnetostratigraphic studies are widely used in conjunction with the geomagnetic polarity time scale (GPTS) to date events in the range 0 to 5 million years ago. A critical tie point on the GPTS is the potassium-argon age of the most recent (Brunhes-Matuyama) geomagnetic field reversal. Astronomical values for the forcing frequencies observed in the oxygen isotope record in Ocean Drilling Project site 677 suggest that the age of this last reversal is 780 ka (thousand years ago), whereas the potassium-argon-based estimate is 730 ka. Results from 4039; Ar incremental heating studies on a series of lavas from Maui that straddle the Brunhes-Matuyama reversal give an age of 783 + 11 ka, in agreement with the astronomically derived value. The astronomically based technique appears to be a viable tool for dating young sedimentary sequences.

  16. Anomalous evolution of Ar metastable density with electron density in high density Ar discharge

    International Nuclear Information System (INIS)

    Park, Min; Chang, Hong-Young; You, Shin-Jae; Kim, Jung-Hyung; Shin, Yong-Hyeon

    2011-01-01

    Recently, an anomalous evolution of argon metastable density with plasma discharge power (electron density) was reported [A. M. Daltrini, S. A. Moshkalev, T. J. Morgan, R. B. Piejak, and W. G. Graham, Appl. Phys. Lett. 92, 061504 (2008)]. Although the importance of the metastable atom and its density has been reported in a lot of literature, however, a basic physics behind the anomalous evolution of metastable density has not been clearly understood yet. In this study, we investigated a simple global model to elucidate the underlying physics of the anomalous evolution of argon metastable density with the electron density. On the basis of the proposed simple model, we reproduced the anomalous evolution of the metastable density and disclosed the detailed physics for the anomalous result. Drastic changes of dominant mechanisms for the population and depopulation processes of Ar metastable atoms with electron density, which take place even in relatively low electron density regime, is the clue to understand the result.

  17. Precambrian evolution of the Salalah Crystalline Basement from structural analysis and 40Ar/39Ar geochronology

    Science.gov (United States)

    Al-Doukhi, Hanadi Abulateef

    The Salalah Crystalline Basement (SCB) is the largest Precambrian exposure in Oman located on the southern margin of the Arabian Plate at the Arabian Sea shore. This work used remote sensing, detailed structural analysis and the analysis of ten samples using 40Ar/39Ar age dating to establish the Precambrian evolution of the SCB by focusing on its central and southwestern parts. This work found that the SCB evolved through four deformational events that shaped its final architecture: (1) Folding and thrusting event that resulted in the emplacement of the Sadh complex atop the Juffa complex. This event resulted in the formation of possibly N-verging nappe structure; (2) Regional folding event around SE- and SW-plunging axes that deformed the regional fabric developed during the N-verging nappe structure and produced map-scale SE- and SW-plunging antiforms shaping the complexes into a semi-dome structure; (3) Strike-slip shearing event that produced a conjugate set of NE-trending sinistral and NW-trending dextral strike-slip shear zones; and (4) Localized SE-directed gravitational collapse manifested by top-to-the-southeast kinematic indicators. Deformation within the SCB might have ceased by 752.2+/-2.7 Ma as indicated by an age given by an undeformed granite. The thermochron of samples collected throughout the SCB complexes shows a single cooling event that occurred between about 800 and 760 Ma. This cooling event could be accomplished by crustal exhumation resulting in regional collapse following the prolonged period of the contractional deformation of the SCB. This makes the SCB a possible metamorphic core complex.

  18. Exhumation history of the NW Indian Himalaya revealed by fission track and 40Ar/39Ar ages

    Science.gov (United States)

    Schlup, Micha; Steck, Albrecht; Carter, Andrew; Cosca, Michael; Epard, Jean-Luc; Hunziker, Johannes

    2011-01-01

    New fission track and Ar/Ar geochronological data provide time constraints on the exhumation history of the Himalayan nappes in the Mandi (Beas valley) — Tso Morari transect of the NW Indian Himalaya. Results from this and previous studies suggest that the SW-directed North Himalayan nappes were emplaced by detachment from the underthrusted upper Indian crust by 55 Ma and metamorphosed by ca. 48–40 Ma. The nappe stack was subsequently exhumed to shallow upper crustal depths (

  19. Bone blood flow measured by 41Ar clearance formed by 44Ca(n,α)41Ar

    International Nuclear Information System (INIS)

    Rosenthal, M.S.; DeLuca, P.M. Jr.; Pearson, D.W.; Nickles, R.J.

    1983-01-01

    A technique to measure regional inert gas washout in bone, in vivo, by measuring 41 Ar clearance formed by fast-neutron activation of 44 Ca has been developed. Following fast-neutron irradiation of whole rats, the perfusion-limited clearance of 41 Ar was measured for both dead and living rats. The clearance rate for the live rats indicate that the bone perfusion is in the range of 3 to 20 ml/100 Argon distribution volume

  20. The potential of AR-V7 as a therapeutic target.

    Science.gov (United States)

    Uo, Takuma; Plymate, Stephen R; Sprenger, Cynthia C

    2018-03-01

    The androgen receptor variant AR-V7 is gaining attention as a potential predictive marker for as well as one of the resistance mechanisms to the most current anti-androgen receptor (AR) therapies in castration-resistant prostate cancer (CRPC). Accordingly, development of next-generation drugs that directly or indirectly target AR-V7 signaling is urgently needed. Areas covered: We review proposed mechanisms of drug resistance in relation to AR-V7 status, the mechanisms of generation of AR-V7, and its transcriptome, cistrome, and interactome. Pharmacological agents that interfere with these processes are being developed to counteract pan AR and AR-V7-specific signaling. Also, we address the current status of the preclinical and clinical studies targeting AR-V7 signaling. Expert opinion: AR-V7 is considered a true therapeutic target, however, it remains to be determined if AR-V7 is a principal driver or merely a bystander requiring heterodimerization with co-expressed full-length AR or other variants to drive CRPC progression. While untangling AR-V7 biology, multiple strategies are being developed to counteract drug resistance, including selective blockade of AR-V7 signaling as well as inhibition of pan-AR signaling. Ideally anti-AR therapies will be combined with agents preventing activation and enrichment of AR negative tumor cells that are otherwise depressed by AR activity axis.

  1. The mass of sup 3 sup 2 Ar and sup 3 sup 3 Ar for fundamental tests

    CERN Document Server

    Blaum, K; Beck, D; Bollen, G; Herfurth, F; Kellerbauer, A G; Kluge, H J; Sauvan, E; Schwarz, S

    2003-01-01

    Masses of the short-lived radionuclides sup 3 sup 2 Ar (T sub 1 sub / sub 2 = 98 ms) sup 3 sup 3 Ar (T sub 1 sub / sub 2 = 173 ms) have been determined with the Penning trap mass spectrometer ISOLTRAP. Relative uncertainties of 6.0 x 10 sup - sup 8 (delta m = 1.8 keV) and 1.4 x 10 sup - sup 8 (delta m = 0.44 keV), respectively, have been achieved. At present, these new mass data serve as the most stringent test of the quadratic form of the isobaricmultiplet mass equation IMME. Furthermore, the improved accuracy for the mass of sup 3 sup 2 Ar yields a better constraint on scalar contributions to the weak interaction. New mass values have also been measured for sup 4 sup 4 Ar and sup 4 sup 5 Ar, and a 20 sigma deviation for sup 4 sup 4 Ar from the literature value was found and interpreted.

  2. Energy dependence of the reaction rate constants of Ar+, Ar++ and N2+ ions with Cl2

    International Nuclear Information System (INIS)

    Lukac, P.; Holubcik, L.; Morva, I.; Lindinger, W.

    2002-01-01

    Dry etching processes using low temperature plasmas in Cl 2 and in Cl 2 -noble gas or nitrogen mixtures are common in the manufacture of semiconductor devices, but their chemical mechanisms are often poorly understood. Results are given for the reaction rate constant measurements of Ar + , Ar ++ , N 2 + ions with chlorine as a function of mean relative kinetic energy. The experiments were performed by using the innsbruck flow drift tube (IFDT) apparatus. Measurements were done at various E/N values, where E is the electric field strength and N the buffer gas density in the drift section. The mean relative kinetic energy KE CM between the ions and the neutral chlorine Cl 2 was calculated using the Wanniers formula. It was found that The N 2 + , Ar + and Ar ++ positive ions react with chlorine Cl 2 very fast and the corresponding reaction rate coefficients depend on the mean relative kinetic energy. For the reaction of Ar - with Cl 2 , its reaction coefficient depends also on the buffer gas. It can imply the enhancement of Cl 2 + ions during etching of Si in the Ar/Cl 2 mixtures. (nevyjel)

  3. Accurate and precise 40Ar/39Ar dating by high-resolution, multi-collection, mass spectrometry

    DEFF Research Database (Denmark)

    Storey, Michael; Rivera, Tiffany; Flude, Stephanie

    New generation, high resolution, multi-collector noble gas mass spectrometers equipped with ion-counting electron multipliers provide opportunities for improved accuracy and precision in 40Ar/39Ar dating. Here we report analytical protocols and age cross-calibration studies using a NU-Instruments......New generation, high resolution, multi-collector noble gas mass spectrometers equipped with ion-counting electron multipliers provide opportunities for improved accuracy and precision in 40Ar/39Ar dating. Here we report analytical protocols and age cross-calibration studies using a NU......-Instruments multi-collector Noblesse noble gas mass spectrometer configured with a faraday detector and three ion-counting electron multipliers. The instrument has the capability to measure several noble gas isotopes simultaneously and to change measurement configurations instantaneously by the use of QUAD lenses...... (zoom optics). The Noblesse offer several advantages over previous generation noble gas mass spectrometers and is particularly suited for single crystal 40Ar/39Ar dating because of: (i) improved source sensitivity (ii) ion-counting electron multipliers, which have much lower signal to noise ratios than...

  4. Spectroscopic and electric dipole properties of Sr+Ar and SrAr systems including high excited states

    Science.gov (United States)

    Hamdi, Rafika; Abdessalem, Kawther; Dardouri, Riadh; Al-Ghamdi, Attieh A.; Oujia, Brahim; Gadéa, Florent Xavier

    2018-01-01

    The spectroscopic properties of the fundamental and several excited states of Sr+Ar and SrAr, Van der Waals systems are investigated by employing an ab initio method in a pseudo-potential approach. The potential energy curves and the spectroscopic parameters are displayed for the 1-10 2Σ+, 1-6 2Π and 1-3 2Δ electronic states of the Sr+Ar molecule and for the 1-6 1Σ+, 1-4 3Σ+, 1-3 1,3Π and 1-3 1,3Δ states of the neutral molecule SrAr. In addition, from these curves, the vibrational levels and their energy spacing are deduced for Σ+, Π and Δ symmetries. The spectra of the permanent and transition dipole moments are studied for the 1,3Σ+ states of SrAr, which are considered to be two-electron systems and 2Σ+ states of the single electron Sr+Ar ion. The spectroscopic parameters obtained for each molecular system are compared with previous theoretical and experimental works. A significant correlation revealed the accuracy of our results.

  5. Extension of the lod score: the mod score.

    Science.gov (United States)

    Clerget-Darpoux, F

    2001-01-01

    In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed phenotypes. To address the case of linkage studies for diseases with unknown mode of inheritance, we suggested (Clerget-Darpoux et al., 1986) extending the lod score function to a so-called mod score function. In this function, the variables are both the recombination fraction and the disease model parameters. Maximizing the mod score function over all these parameters amounts to maximizing the probability of marker data conditional on the disease status. Under the absence of linkage, the mod score conforms to a chi-square distribution, with extra degrees of freedom in comparison to the lod score function (MacLean et al., 1993). The mod score is asymptotically maximum for the true disease model (Clerget-Darpoux and Bonaïti-Pellié, 1992; Hodge and Elston, 1994). Consequently, the power to detect linkage through mod score will be highest when the space of models where the maximization is performed includes the true model. On the other hand, one must avoid overparametrization of the model space. For example, when the approach is applied to affected sibpairs, only two constrained disease model parameters should be used (Knapp et al., 1994) for the mod score maximization. It is also important to emphasize the existence of a strong correlation between the disease gene location and the disease model. Consequently, there is poor resolution of the location of the susceptibility locus when the disease model at this locus is unknown. Of course, this is true regardless of the statistics used. The mod score may also be applied in a candidate gene strategy to model the potential effect of this gene in the disease. Since, however, it

  6. Problems in the K-Ar dating of Quaternary volcanic rocks younger than 1 Ma

    International Nuclear Information System (INIS)

    Takaoka, Nobuo

    1989-01-01

    The assumption that the 40 Ar/ 36 Ar ratio of Ar trapped in volcanic rocks at eruption is atmospheric often gives a large systematic error in the K-Ar dating of Quaternary volcanic rocks younger than 1 Ma. There are two possible sources of error, the existence of excess Ar and mass-fractionated, initial Ar. The major source of excess Ar is supposed to be magma. The 40 Ar/ 36 Ar ratio for magmatic Ar in the North-East Japan arc is tentatively estimated to be 340±10 from measurements of Ar in large phenocrysts separated from Quaternary volcanic rocks. Separation of phenocrysts is the most effective to decrease the systematic error caused by excess Ar. The mass-fractionation of initial Ar should give the 38 Ar/ 36 Ar ratio which was changed from the atmospheric ratio. This can be checked by determining the 38 Ar/ 36 Ar ratio in samples. Since the systematic error caused by the mass-fractionated, initial Ar increases greatly with the increasing atmospheric Ar correction, it is important to correct the result for the mass-fractionation. Correction formulae are given. The error sources other than those mentioned above are uncertainty in the blank correction and instabilities in the sensitivity of spectrometer and the Ar isotopic ratio measurement. In order to increase accuracy of the K-Ar age obtained, to check the systematic errors by measuring samples together with standard samples is of great importance in the K-Ar dating of very young volcanic rocks. (author)

  7. The 40Ar/39Ar and U/Pb dating of young rhyolites in the Kos-Nisyros volcanic complex, Eastern Aegean Arc, Greece: Age discordance due to excess 40Ar in biotite

    Science.gov (United States)

    Bachmann, O.; Schoene, B.; Schnyder, C.; Spikings, R.

    2010-08-01

    High-precision dating of Quaternary silicic magmas in the active Kos-Nisyros volcanic center (Aegean Arc, Greece) by both 40Ar/39Ar on biotite and U/Pb on zircon reveals a complex geochronological story. U/Pb ID-TIMS multi and single-grain zircon analyses from 3 different units (Agios Mammas and Zini domes, Kefalos Serie pyroclasts) range in age from 0.3 to 0.5 to 10-20 Ma. The youngest dates provide the maximum eruption age, while the oldest zircons indicate inheritance from local continental crust (Miocene and older). Step-heating 40Ar/39Ar experiments on 1-3 crystals of fresh biotite yielded highly disturbed Ar-release patterns with plateau ages typically older than most U/Pb ages. These old plateau ages are probably not a consequence of inheritance from xenocrystic biotites because Ar diffuses extremely fast at magmatic temperatures and ratios are reset within a few days. On the basis of (1) elevated and/or imprecise 40Ar/36Ar ratios, (2) shapes of the Ar release spectra, and (3) a high mantle 3He flux in the Kos-Nisyros area, we suggest that biotite crystals retained some mantle 40Ar that led to the observed, anomalously old ages. In contrast, sanidine crystals from the only sanidine-bearing unit in the Kos-Nisyros volcanic center (the caldera-forming Kos Plateau Tuff) do not appear to store any excess 40Ar relative to atmospheric composition. The eastern edge of the Aegean Arc is tectonically complex, undergoing rapid extension and located close to a major structural boundary. In such regions, which are characterized by high fluxes of mantle volatiles, 40Ar/39Ar geochronology on biotite can lead to erroneous results due to the presence of excess 40Ar and should be checked either against 40Ar/39Ar sanidine or U/Pb zircon ages.

  8. Acoustic Resonance Spectroscopy (ARS) Munition Classification System enhancements. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vela, O.A.; Huggard, J.C.

    1997-09-18

    Acoustic Resonance Spectroscopy (ARS) is a non-destructive evaluation technology developed at the Los Alamos National Laboratory (LANL). This technology has resulted in three generations of instrumentation, funded by the Defense Special Weapons Agency (DSWA), specifically designed for field identification of chemical weapon (CW) munitions. Each generation of ARS instrumentation was developed with a specific user in mind. The ARS1OO was built for use by the U.N. Inspection Teams going into Iraq immediately after the Persian Gulf War. The ARS200 was built for use in the US-Russia Bilateral Chemical Weapons Treaty (the primary users for this system are the US Onsite Inspection Agency (OSIA) and their Russian counterparts). The ARS300 was built with the requirements of the Organization for the Prohibition of Chemical Weapons (OPCW) in mind. Each successive system is an improved version of the previous system based on learning the weaknesses of each and, coincidentally, on the fact that more time was available to do a requirements analysis and the necessary engineering development. The ARS300 is at a level of development that warrants transferring the technology to a commercial vendor. Since LANL will supply the computer software to the selected vendor, it is possible for LANL to continue to improve the decision algorithms, add features where necessary, and adjust the user interface before the final transfer occurs. This paper describes the current system, ARS system enhancements, and software enhancements. Appendices contain the Operations Manual (software Version 3.01), and two earlier reports on enhancements.

  9. 40Ar/ 39Ar, K-Ar and 230Th- 238U dating of the Laschamp excursion: A radioisotopic tie-point for ice core and climate chronologies

    Science.gov (United States)

    Singer, Brad S.; Guillou, Hervé; Jicha, Brian R.; Laj, Carlo; Kissel, Catherine; Beard, Brian L.; Johnson, Clark M.

    2009-08-01

    A brief period of enhanced 10Be flux that straddles the interstadial warm period known as Dansgaard-Oeschger event 10 in Greenland and its counterpart in Antarctica, the Antarctic Isotope Maximum 10 is but one consequence of the weakening of Earth's magnetic field associated with the Laschamp excursion. This 10Be peak measured in the GRIP ice core is dated at 41,250 y b2k (= before year 2000 AD) in the most recent GICC05 age model obtained from the NorthGRIP core via multi-parameter counting of annual layers. Uncertainty in the age of the 10Be peak is, however, no better than ± 1630 y at the 95% confidence level, reflecting accumulated error in identifying annual layers. The age of the Laschamp excursion [Guillou, H., Singer, B.S., Laj, C., Kissel, C., Scaillet, S., Jicha, B., 2004. On the age of the Laschamp geomagnetic excursion. Earth Planet. Sci. Lett. 227, 331-343.] is revised on the basis of new 40Ar/ 39Ar, unspiked K-Ar and 238U- 230Th data from three lava flows in the Massif Central, France, together with the 40Ar/ 39Ar age of a transitionally magnetized lava flow at Auckland, New Zealand. Combined, these data yield an age of 40,700 ± 950 y b2k, where the uncertainty includes both analytical and systematic ( 40K and 230Th decay constant) errors. Taking the radioisotopic age as a calibration tie point suggests that the layer-counting chronologies for the NorthGRIP and GISP2 ice cores are more accurate and precise than previously thought at depths corresponding to the Laschamp excursion.

  10. State-specific transport properties of electronically excited Ar and C

    Science.gov (United States)

    Istomin, V. A.; Kustova, E. V.

    2018-05-01

    In the present study, a theoretical model of state-resolved transport properties in electronically excited atomic species developed earlier is applied to argon and carbon atomic species. It is shown that for Ar and C, similarly to the case of atomic nitrogen and oxygen, the Slater-like models can be applied to calculate diameters of electronically excited atoms. Using the Slater-like model it is shown that for half-filled N (2 px1py1pz1) and full-filled Ar (3 px2py2pz2) electronic shells the growth of atomic radius goes slowly compared to C (2 px1py1) and O (2 px2py1pz1). The effect of collision diameters on the transport properties of Ar and C is evaluated. The influence of accounted number of electronic levels on the transport coefficients is examined for the case of Boltzmann distributions over electronic energy levels. It is emphasized that in the temperature range 1000-14000 K, for Boltzmann-like distributions over electronic states the number of accounted electronic levels do not influence the transport coefficients. Contrary to this, for higher temperatures T > 14000 K this effect becomes of importance, especially for argon.

  11. Imaging the electron transfer reaction of Ne2+ with Ar using position-sensitive coincidence spectroscopy

    International Nuclear Information System (INIS)

    Harper, Sarah M; Hu Wanping; Price, Stephen D

    2002-01-01

    A new experiment, employing position-sensitive detection coupled with time-of-flight mass spectrometry, has been used to investigate the single-electron transfer reaction between Ne 2+ and Ar by detecting the resulting pairs of singly charged ions in coincidence. The experimental technique allows the determination of the individual velocity vectors of the ionic products, in the centre-of-mass frame, for each reactive event detected. The experiments show that forward scattering dominates the reactivity, although a bimodal angular distribution is apparent. In addition, the spectra show that at laboratory frame collision energies from 4-14 eV the reactivity is dominated by Ne 2+ (2p 4 , 3 P) accepting an electron from an argon atom to form the ground state of Ne + together with an Ar + ion in an excited electronic level, predominantly arising from the Ar + (3s 2 3p 4 3d) configuration. The form of this reactivity, and the differences between the reactivity observed in these experiments and those performed at higher collision energies, are well reproduced by Landau-Zener theory

  12. Various scoring systems for predicting mortality in Intensive Care Unit

    African Journals Online (AJOL)

    2015-12-07

    Dec 7, 2015 ... Mortality rate was higher in patients admitted from wards other than surgery ... evaluate the predictability of various severity of illness scores, and ..... Livingston BM, MacKirdy FN, Howie JC, Jones R, Norrie JD. Assessment of.

  13. From Rasch scores to regression

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    Rasch models provide a framework for measurement and modelling latent variables. Having measured a latent variable in a population a comparison of groups will often be of interest. For this purpose the use of observed raw scores will often be inadequate because these lack interval scale propertie....... This paper compares two approaches to group comparison: linear regression models using estimated person locations as outcome variables and latent regression models based on the distribution of the score....

  14. Fusion-fission in Ar-heavy nuclei collisions

    International Nuclear Information System (INIS)

    Zaric, Alexandre

    1984-01-01

    Fusion-fission products have been studied for three reactions: Ar + Au, Ar + Bi and Ar + U (5.25-7.5 MeV/u). By measuring symmetric fragmentation components (fission-like events), cross sections for fusion were deduced and compared with the prediction of static and dynamic models. With increasing projectile energy, the width of the mass distributions strongly increases for the two lighter systems. By contrast, for Ar + U it remains essentially constant at a very large value. These results clearly demonstrate that the large increase of the width of the mass distribution cannot be attributed simply to large values of the angular momentum. However, they can be explained by the occurrence of a different dissipative process, fast fission, which can be expected if there is no barrier to fission. For the reaction Ar + Au, the total kinetic-energy distributions were also studied in detail. In this case fast fission occurs only at high incident energy. The average total kinetic energy (TKE) was found to be constant with increasing energy. (author) [fr

  15. Investigation of the energy levels of 38AR

    International Nuclear Information System (INIS)

    Waanders, F.B.

    1975-07-01

    In this project information on the energy levels of 38 Ar was obtained by means of the (p,γ) reaction. The 1,1 MeV Cockroft-Walton accelerator of the Potchefstroom University for CHE was used to produce the proton beam while a 80 cm 3 Ge(Li) detector was used to detect the gamma-rays. Precise gamma-branchings were determined for 50 bound levels, of which four have not previously been determined. These branchings were obtained from the 28 resonances studied in the 37 Cl(p,γ) 38 Ar reaction. The resonance with a proton energy of (592 plus minus 3) keV was not detected previously. The resonance energies, Q-value and energies of the bound levels used in this project were taken from the study done by Alderliesten. The mean lifetimes of a few bound levels of 38 Ar were measured by means of the doppler shift attenuation method. The results concerning the bound states and mean lifetimes are in good agreement with previous experiments. Limitations on the spin and parities of 19 (p,γ) resonances have been set by means of Weisskopf estimates. Only those cases for which the spin could be limited to two values are discussed in the text. A summary of experimental data obtained on 38 Ar is compared with the results from shellmodel calculations done by various workers. A short discussion on the analogue states in 38 Ar is also given [af

  16. ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer.

    Science.gov (United States)

    Lev, Avital; Lulla, Amriti R; Ross, Brian C; Ralff, Marie D; Makhov, Petr B; Dicker, David T; El-Deiry, Wafik S

    2018-05-01

    Androgen receptor (AR) signaling plays a key role in prostate cancer progression, and androgen deprivation therapy (ADT) is a mainstay clinical treatment regimen for patients with advanced disease. Unfortunately, most prostate cancers eventually become androgen-independent and resistant to ADT with patients progressing to metastatic castration-resistant prostate cancer (mCRPC). Constitutively activated AR variants (AR-V) have emerged as mediators of resistance to AR-targeted therapy and the progression of mCRPC, and they represent an important therapeutic target. Out of at least 15 AR-Vs described thus far, AR-V7 is the most abundant, and its expression correlates with ADT resistance. ONC201/TIC10 is the founding member of the imipridone class of small molecules and has shown anticancer activity in a broad range of tumor types. ONC201 is currently being tested in phase I/II clinical trials for advanced solid tumors, including mCRPC, and hematologic malignancies. There has been promising activity observed in patients in early clinical testing. This study demonstrates preclinical single-agent efficacy of ONC201 using in vitro and in vivo models of prostate cancer. ONC201 has potent antiproliferative and proapoptotic effects in both castration-resistant and -sensitive prostate cancer cells. Furthermore, the data demonstrate that ONC201 downregulates the expression of key drivers of prostate cancer such as AR-V7 and downstream target genes including the clinically used biomarker PSA (KLK3). Finally, the data also provide a preclinical rationale for combination of ONC201 with approved therapeutics for prostate cancer such as enzalutamide, everolimus (mTOR inhibitor), or docetaxel. Implications: The preclinical efficacy of ONC201 as a single agent or in combination, in hormone-sensitive or castration-resistant prostate cancer, suggests the potential for immediate clinical translation. Mol Cancer Res; 16(5); 754-66. ©2018 AACR . ©2018 American Association for Cancer

  17. 40Ar-39Ar dating of terrestrial and exterrestrial materials. Basalts from the Japan Sea floor, Deccan Plateau and meteorites from Antarctica

    International Nuclear Information System (INIS)

    Kaneoka, Ichiro; Takigami, Yutaka.

    1994-01-01

    Through a series of 40 Ar- 39 Ar dating for terrestrial and exterrestrial samples, the results for basalts from the Japan Sea floor, Deccan Plateau and for meteorites from Antarctica give significant information concerning their formation histories. 40 Ar- 39 Ar ages of basalts from the Japan Sea floor give a constraint that the Japan Sea floor was formed at least 20 Ma. 40 Ar- 39 Ar ages for dyke samples from the Deccan Plateau indicate a possibility for the occurrence of a little younger ages than that of the main plateau formations by a few million years. Meteorites collected from Antarctica show some variable 40 Ar- 39 Ar ages reflecting their different thermal histories. (author)

  18. External validation of the NOBLADS score, a risk scoring system for severe acute lower gastrointestinal bleeding.

    Directory of Open Access Journals (Sweden)

    Tomonori Aoki

    Full Text Available We aimed to evaluate the generalizability of NOBLADS, a severe lower gastrointestinal bleeding (LGIB prediction model which we had previously derived when working at a different institution, using an external validation cohort. NOBLADS comprises the following factors: non-steroidal anti-inflammatory drug use, no diarrhea, no abdominal tenderness, blood pressure ≤ 100 mmHg, antiplatelet drug use, albumin < 3.0 g/dL, disease score ≥ 2, and syncope.We retrospectively analyzed 511 patients emergently hospitalized for acute LGIB at the University of Tokyo Hospital, from January 2009 to August 2016. The areas under the receiver operating characteristic curves (ROCs-AUCs for severe bleeding (continuous and/or recurrent bleeding were compared between the original derivation cohort and the external validation cohort.Severe LGIB occurred in 44% of patients. Several clinical factors were significantly different between the external and derivation cohorts (p < 0.05, including background, laboratory data, NOBLADS scores, and diagnosis. The NOBLADS score predicted the severity of LGIB with an AUC value of 0.74 in the external validation cohort and one of 0.77 in the derivation cohort. In the external validation cohort, the score predicted the risk for blood transfusion need (AUC, 0.71, but was not adequate for predicting intervention need (AUC, 0.54. The in-hospital mortality rate was higher in patients with a score ≥ 5 than in those with a score < 5 (AUC, 0.83.Although the external validation cohort clinically differed from the derivation cohort in many ways, we confirmed the moderately high generalizability of NOBLADS, a clinical risk score for severe LGIB. Appropriate triage using this score may support early decision-making in various hospitals.

  19. High-resolution Auger spectroscopy on 79 MeV Ar5+, 89 MeV Ar6+, and 136 MeV Ar7+ ions after excitation by helium

    International Nuclear Information System (INIS)

    Schneider, T.

    1988-01-01

    In this thesis the atomic structure of highly excited Ar 6+ and Ar 7+ ions was studied. For this 79 MeV Ar 5+ , 89 MeV Ar 6+ , and 136 MeV Ar 7+ ions of a heavy ion accelerator were excited by a He gas target to autoionizing states and the Auger electrons emitted in the decay were measured in highly-resolving state. The spectra were taken under an observational angle of zero degree relative to the beam axis in order to minimize the kinematical broadening of the Auger lines. (orig./HSI) [de

  20. Augmented reality (AR and virtual reality (VR applied in dentistry

    Directory of Open Access Journals (Sweden)

    Ta-Ko Huang

    2018-04-01

    Full Text Available The OSCE is a reliable evaluation method to estimate the preclinical examination of dental students. The most ideal assessment for OSCE is used the augmented reality simulator to evaluate. This literature review investigated a recently developed in virtual reality (VR and augmented reality (AR starting of the dental history to the progress of the dental skill. As result of the lacking of technology, it needs to depend on other device increasing the success rate and decreasing the risk of the surgery. The development of tracking unit changed the surgical and educational way. Clinical surgery is based on mature education. VR and AR simultaneously affected the skill of the training lesson and navigation system. Widely, the VR and AR not only applied in the dental training lesson and surgery, but also improved all field in our life. Keywords: OSCE, Dental simulator, Augmented reality, Virtual reality, Dentistry

  1. Augmented reality (AR) and virtual reality (VR) applied in dentistry.

    Science.gov (United States)

    Huang, Ta-Ko; Yang, Chi-Hsun; Hsieh, Yu-Hsin; Wang, Jen-Chyan; Hung, Chun-Cheng

    2018-04-01

    The OSCE is a reliable evaluation method to estimate the preclinical examination of dental students. The most ideal assessment for OSCE is used the augmented reality simulator to evaluate. This literature review investigated a recently developed in virtual reality (VR) and augmented reality (AR) starting of the dental history to the progress of the dental skill. As result of the lacking of technology, it needs to depend on other device increasing the success rate and decreasing the risk of the surgery. The development of tracking unit changed the surgical and educational way. Clinical surgery is based on mature education. VR and AR simultaneously affected the skill of the training lesson and navigation system. Widely, the VR and AR not only applied in the dental training lesson and surgery, but also improved all field in our life. Copyright © 2018. Published by Elsevier Taiwan.

  2. [VR and AR Applications in Medical Practice and Education].

    Science.gov (United States)

    Hsieh, Min-Chai; Lin, Yu-Hsuan

    2017-12-01

    As technology advances, mobile devices have gradually turned into wearable devices. Furthermore, virtual reality (VR), augmented reality (AR), and mixed reality (MR) are being increasingly applied in medical fields such as medical education and training, surgical simulation, neurological rehabilitation, psychotherapy, and telemedicine. Research results demonstrate the ability of VR, AR, and MR to ameliorate the inconveniences that are often associated with traditional medical care, reduce incidents of medical malpractice caused by unskilled operations, and reduce the cost of medical education and training. What is more, the application of these technologies has enhanced the effectiveness of medical education and training, raised the level of diagnosis and treatment, improved the doctor-patient relationship, and boosted the efficiency of medical execution. The present study introduces VR, AR, and MR applications in medical practice and education with the aim of helping health professionals better understand the applications and use these technologies to improve the quality of medical care.

  3. A microdose study of ¹⁴C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung.

    Science.gov (United States)

    Lappin, G; Boyce, M J; Matzow, T; Lociuro, S; Seymour, M; Warrington, S J

    2013-09-01

    To explore, in a microdose (phase-0) study, the pharmacokinetics, bioavailability and concentrations in key compartments of the lung, of AR-709, a novel diaminopyrimidine antibiotic for the treatment of respiratory infection. Four healthy men each received two single, 100 μg microdoses of ¹⁴C-AR-709, 7 days apart: the first was administered intravenously (IV), the second orally. Plasma pharmacokinetics of ¹⁴C and unchanged AR-709 were obtained by high-performance liquid chromatography and accelerator mass spectrometry (AMS). Next, 15 healthy men received a single, 100 μg microdose of ¹⁴C-AR-709 IV. Plasma, bronchoalveolar lavage fluid, alveolar macrophages and bronchial mucosal biopsy samples were analysed by AMS. After IV administration, clearance of AR-709 was 496 mL/min, volume of distribution was 1,700 L and the absolute oral bioavailability was 2.5 %. Excretion in urine was negligible. At 8-12 h after IV dosing, ¹⁴C concentrations in lung samples were 15- (bronchial mucosa) to 200- (alveolar macrophages) fold higher than in plasma. In alveolar macrophages, ¹⁴C was still mostly associated with AR-709 at 12 h after dosing. The results of this microdose study indicate that AR-709 attains concentrations appreciably higher within the lung than in plasma. Its low oral bioavailability however, precludes oral administration. Although IV administration would appear to be an effective route of administration, this would limit the use of AR-709 to a clinical setting and would therefore be economically unsustainable. If further clinical development were to be undertaken, therefore, an alternative route of administration would be necessary.

  4. Defect production in Ar irradiated graphene membranes under different initial applied strains

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Asencio, J., E-mail: jesusmartinez@ua.es [Dept. Física Aplicada, Facultad de Ciencias, Fase II, Universidad de Alicante, Alicante E-036090 (Spain); Ruestes, C.J.; Bringa, E. [CONICET and Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza 5500 (Argentina); Caturla, M.J. [Dept. Física Aplicada, Facultad de Ciencias, Fase II, Universidad de Alicante, Alicante E-036090 (Spain)

    2017-02-15

    Highlights: • Defects in graphene membranes are formed due to 140 eV Ar ions irradiation using MD. • Different initial strains are applied, which influence the type and number of defects. • Mono-vacancies, di-vacancies and tri-vacancies production behaves linearly with dose. • The total number of defects under compression is slightly higher than under tension. - Abstract: Irradiation with low energy Ar ions of graphene membranes gives rise to changes in the mechanical properties of this material. These changes have been associated to the production of defects, mostly isolated vacancies. However, the initial state of the graphene membrane can also affect its mechanical response. Using molecular dynamics simulations we have studied defect production in graphene membranes irradiated with 140 eV Ar ions up to a dose of 0.075 × 10{sup 14} ions/cm{sup 2} and different initial strains, from −0.25% (compressive strain) to 0.25% (tensile strain). For all strains, the number of defects increases linearly with dose with a defect production of about 80% (80 defects every 100 ions). Defects are mostly single vacancies and di-vacancies, although some higher order clusters are also observed. Two different types of di-vacancies have been identified, the most common one being two vacancies at first nearest neighbours distance. Differences in the total number of defects with the applied strain are observed which is related to the production of a higher number of di-vacancies under compressive strain compared to tensile strain. We attribute this effect to the larger out-of-plane deformations of compressed samples that could favor the production of defects in closer proximity to others.

  5. Smoking habit and psychometric scores: a community study.

    Science.gov (United States)

    Waal-Manning, H J; de Hamel, F A

    1978-09-13

    During the Milton health survey subjects completed a psychometric inventory consisting of the 48 questions of the Middlesex Hospital questionnaire (MHQ) and 26 from the hostility and direction of hostility questionnaire (HDHQ) designed to examine nine psychological dimensions. The 1209 subjects were classified into smoking categories and the scores for each psychometric trait were calculated. Women scored higher than men and heavy smokers scored higher than "never smokers". The psychometric traits and the scores of the four smoking categories after correcting for age and Quetelet's index showed statistically significant differences by analysis of variance in respect of somatic anxiety and depression for both men and women; and free-floating anxiety, phobic anxiety, hysteria, acting out hostility, self criticism and guilt in women. For somatic anxiety the increase in score almost exactly paralleled the increasing quantity of tobacco consumed.

  6. Effects of lamellae size distributions from 40Ar/39Ar on sedimentary thermo-chronology in the San Joaquin Basin

    International Nuclear Information System (INIS)

    Jepsen, A.-M.; Lerche, I.; Thomsen, R.O.

    1990-01-01

    A model description is provided for the release of 40 Ar/ 39 Ar from detrital microclines which specifically includes the effects of grain size distributions, thus allowing smaller grains to release argon faster than the more retentive larger grains. The model also includes the effects of sedimentary thermal history after burial influencing the pre-depositional 40 Ar/ 30 Ar ratio. Application of the model to the measured age spectra from six depths in the Tejon Block and four in the Basin Block of the San Joaquin Basin demonstrates that the grain size distribution effect plays a major role in masking the extraction of thermal history information from the observed age spectra. In addition, the grain size effect is not systematic with depth, and other competing effects, such as isotopic fractionation of diffusion coefficients, multi-provenance depositional supply, and variable concentrations of 40 Ar and 39 K per microcline at burial deposition time, make the extraction of thermal history information even more difficult. (author)

  7. Regulation of AR Degradation and Function by Ubiquitylation

    Science.gov (United States)

    2015-10-01

    have carried out similar analyses from androgen ( DHT ) stimulated VCaP cells. The combined results from a series of LC-MS/MS analyses of DHT stimulated...minus or plus DHT . AR was then isolated from whole cell lysates and run on SDS-PAGE, followed by excision of area ~100 Kd (mono or possibly oligo...the stably expressed AR WT versus K911R mutant. As shown in figure 1B, the K911R mutant had increased activity in response to 1 nM DHT . Finally

  8. Axenfeld-Rieger syndrome (ARS): A review and case report.

    LENUS (Irish Health Repository)

    Waldron, Jennie M

    2011-08-29

    Axenfeld-Rieger syndrome (ARS) is a rare, autosomal dominant condition characterized by ocular, craniofacial, dental, and periumbilical abnormalities. Relatively little information exists on this syndrome within the dental literature despite the fact that midface hypoplasia and maxillary hypodontia are classical presenting features of this syndrome. This is a case report of a 7-year-old Caucasian female with ARS who presented with significant ocular and dental anomalies. She was also found to have osteopenia. Her dental condition is described, her immediate treatment is shown, and her long-term treatment needs are discussed.

  9. Aspects of What Makes or Breaks a Museum AR Experience

    DEFF Research Database (Denmark)

    Madsen, Claus B.; Madsen, Jacob Boesen; Morrison, Ann

    2012-01-01

    The paper critically evaluates central aspects of an iPad AR application developed for a museum context. The application is designed for children aged 8 to 12 and mixes AR and mini-game elements to convey dramatized historical events. The game has been deployed for roughly 3 months and the findings...... in the paper are supported by extensive in-application activity logging. Actual usage of the application at the museum proved far less extensive than envisaged. Hypotheses for this finding are presented and discussed, with support from the logging data....

  10. Interatomic scattering in energy dependent photoelectron spectra of Ar clusters

    Energy Technology Data Exchange (ETDEWEB)

    Patanen, M.; Benkoula, S.; Nicolas, C.; Goel, A. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Antonsson, E. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Physikalische und Theoretische Chemie Institut für Chemie und Biochemie, Fachbereich Biologie, Chemie, Pharmazie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany); Neville, J. J. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick E3B 6E2 (Canada); Miron, C., E-mail: Catalin.Miron@synchrotron-soleil.fr [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Extreme Light Infrastructure - Nuclear Physics (ELI-NP), ‘Horia Hulubei’ National Institute for Physics and Nuclear Engineering, 30 Reactorului Street, RO-077125 Măgurele, Jud. Ilfov (Romania)

    2015-09-28

    Soft X-ray photoelectron spectra of Ar 2p levels of atomic argon and argon clusters are recorded over an extended range of photon energies. The Ar 2p intensity ratios between atomic argon and clusters’ surface and bulk components reveal oscillations similar to photoelectron extended X-ray absorption fine structure signal (PEXAFS). We demonstrate here that this technique allows us to analyze separately the PEXAFS signals from surface and bulk sites of free-standing, neutral clusters, revealing a bond contraction at the surface.

  11. Geological evolution of the Boset-Bericha Volcanic Complex, Main Ethiopian Rift: 40Ar/39Ar evidence for episodic Pleistocene to Holocene volcanism

    Science.gov (United States)

    Siegburg, Melanie; Gernon, Thomas M.; Bull, Jonathan M.; Keir, Derek; Barfod, Dan N.; Taylor, Rex N.; Abebe, Bekele; Ayele, Atalay

    2018-02-01

    The Boset-Bericha Volcanic Complex (BBVC) is one of the largest stratovolcanoes of the northern Main Ethiopian Rift (MER). However, very little is known about its eruptive history, despite the fact that approximately 4 million people live within 100 km of the complex. Here, we combine field observations, morphometric analysis using high-resolution LiDAR data, geochemistry and 40Ar/39Ar geochronology to report the first detailed account of the geological evolution of the BBVC, with a focus on extensive young lava flows covering the two edifices, Gudda and Bericha. These lavas exhibit a bimodal composition ranging dominantly from basaltic rift floor lavas and scoria cones, to pantelleritic trachytes and rhyolite flows at Gudda, and comenditic rhyolites at Bericha. Further, several intermediate compositions are associated with fissure vents along the Boset-Kone segment that also appear to link the silicic centres. We divide the BBVC broadly into four main eruptive stages, comprising: (1) early rift floor emplacement, (2) formation of Gudda Volcano within two main cycles, separated by caldera formation, (3) formation of the Bericha Volcano, and (4) sporadic fissure eruptions. Our new 40Ar/39Ar geochronology, targeting a representative array of these flows, provides evidence for episodic activity at the BBVC from 120 ka to the present-day. We find that low-volume mafic episodes are more frequent ( 10 ka cyclicity) than felsic episodes ( 100 ka cyclicity), but the latter are more voluminous. Over the last 30 ka, mafic to intermediate fissure activity might have reinvigorated felsic activity (over the last 16 ka), manifested as peralkaline lava flows and pyroclastic deposits at Gudda and Bericha. Felsic episodes have on average a higher eruption rate (2-5/1000 years) and productivity at Gudda compared to Bericha (1-2/1000 years). The young age of lavas and current fumarolic activity along the fault system, suggest that the BBVC is still potentially active. Coincident

  12. The power and robustness of maximum LOD score statistics.

    Science.gov (United States)

    Yoo, Y J; Mendell, N R

    2008-07-01

    The maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported. This latter statistic requires higher critical value than the maximum LOD score statistic calculated from a single genetic parameter value. In this paper, we compare the power of maximum LOD scores based on three fixed sets of genetic parameter values with the power of the LOD score obtained after maximizing over the entire range of genetic parameter values. We simulate family data under nine generating models. For generating models with non-zero phenocopy rates, LOD scores maximized over the entire range of genetic parameters yielded greater power than maximum LOD scores for fixed sets of parameter values with zero phenocopy rates. No maximum LOD score was consistently more powerful than the others for generating models with a zero phenocopy rate. The power loss of the LOD score maximized over the entire range of genetic parameters, relative to the maximum LOD score calculated using the correct genetic parameter value, appeared to be robust to the generating models.

  13. Comparative evaluation of the IPCC AR5 CMIP5 versus the AR4 CMIP3 model ensembles for regional precipitation and their extremes over South America

    Science.gov (United States)

    Tolen, J.; Kodra, E. A.; Ganguly, A. R.

    2011-12-01

    The assertion that higher-resolution experiments or more sophisticated process models within the IPCC AR5 CMIP5 suite of global climate model ensembles improves precipitation projections over the IPCC AR4 CMIP3 suite remains a hypothesis that needs to be rigorously tested. The questions are particularly important for local to regional assessments at scales relevant for the management of critical infrastructures and key resources, particularly for the attributes of sever precipitation events, for example, the intensity, frequency and duration of extreme precipitation. Our case study is South America, where precipitation and their extremes play a central role in sustaining natural, built and human systems. To test the hypothesis that CMIP5 improves over CMIP3 in this regard, spatial and temporal measures of prediction skill are constructed and computed by comparing climate model hindcasts with the NCEP-II reanalysis data, considered here as surrogate observations, for the entire globe and for South America. In addition, gridded precipitation observations over South America based on rain gage measurements are considered. The results suggest that the utility of the next-generation of global climate models over the current generation needs to be carefully evaluated on a case-by-case basis before communicating to resource managers and policy makers.

  14. Single-electron capture into Ar+ excited states in Ar2 + Na collision below 12 keV, 1

    International Nuclear Information System (INIS)

    Matsumoto, Atsushi; Tsurubuchi, Seiji; Okuno, Kazuhiko; Ohtani, Shunsuke; Iwai, Tsuruji.

    1979-08-01

    Emission spectra between 2800 and 6000 A have been observed at the ionic energies from 0.2 to 12 keV. Absolute measurements of emission cross-sections have been made for the emission lines coming from ArII excited states at 4 and 8 keV with a crossed-beam technique. Processes of single-electron capture into the ArII 4p- and 4p'-states, with exothermicity of a few eV, take place dominantly (--10 15 cm 2 ), while the endothermic processes producing ArII in the 4d- and 5s-states occur with small cross-sections. Sum of the cross-sections for electron capture into the excited states observed is comparable with the total single-electron capture cross-section estimated from attenuation measurements of ion currents. Possible errors and uncertainties are discussed. (author)

  15. 40Ar/39Ar geochronology at the Instituto de Geociências, USP: instrumentation, analytical procedures, and calibration

    Directory of Open Access Journals (Sweden)

    PAULO M. VASCONCELOS

    2002-06-01

    Full Text Available Laser heating 40Ar/39Ar geochronology provides high analytical precision and accuracy, mum-scale spatial resolution, and statistically significant data sets for the study of geological and planetary processes. A newly commissioned 40Ar/39Ar laboratory at CPGeo/USP, São Paulo, Brazil, equips the Brazilian scientific community with a new powerful tool applicable to the study of geological and cosmochemical processes. Detailed information about laboratory layout, environmental conditions, and instrumentation provides the necessary parameters for the evaluation of the CPGeo/USP 40Ar/39Ar suitability to a diverse range of applications. Details about analytical procedures, including mineral separation, irradiation at the IPEN/CNEN reactor at USP, and mass spectrometric analysis enable potential researchers to design the necessary sampling and sample preparation program suitable to the objectives of their study. Finally, the results of calibration tests using Ca and K salts and glasses, international mineral standards, and in-house mineral standards show that the accuracy and precision obtained at the 40Ar/39Ar laboratory at CPGeo/USP are comparable to results obtained in the most respected laboratories internationally. The extensive calibration and standardization procedures undertaken ensure that the results of analytical studies carried out in our laboratories will gain immediate international credibility, enabling Brazilian students and scientists to conduct forefront research in earth and planetary sciences.A geocronologia de 40Ar/39Ar por aquecimento a laser permite alta precisão e acurácia analítica, tem resolução espacial em escala micrométrica, e fornece um número de dados estatisticamente significantes para o estudo de processos geológicos e planetários. Um recém construído laboratório de 40Ar/39Ar no CPGeo/USP, São Paulo, Brazil, mune a sociedade científica brasileira com uma técnica eficaz aplicável aos estudos geol

  16. Single-electron capture into Ar+ excited states in Ar2++Na collision below 12 keV, 1

    International Nuclear Information System (INIS)

    Matsumoto, Atsushi; Tsurubuchi, Seiji; Iwai, Tsuruji; Ohtani, Shunsuke; Okuno, Kazuhiko

    1980-01-01

    Emission spectra between 2800 and 6000 A have been observed at the ionic energies from 0.2 to 12 keV. Absolute measurements of emission cross-sections have been made for the emission lines coming from ArII excited states at 4 and 8 keV with a crossed-beam technique. Processes of single-electron capture into the ArII 4p- and 4p'-states, with exothermicity of a few eV, take place dominantly (--10 -15 cm 2 ), while the endothermic processes producing ArII in the 4d- and 5s-states occur with small cross-sections. Sum of the cross-sections for electron capture into the excited states observed is comparable with the total single-electron capture cross-section estimated from attenuation measurements of ion currents. Possible errors and uncertainties are discussed. (author)

  17. K-Ar and Ar-Ar dating of the Palaeozoic metamorphic complex from the Mid-Bosnian Schist Mts., Central Dinarides, Bosnia and Hercegovina

    International Nuclear Information System (INIS)

    Pamic, J.; Balogh, K.; Hrvatovic, H.; Balen, D.; Palinkas, L.; Jurkovic, I.

    2004-01-01

    K-Ar and Ar-Ar whole rock and mineral ages are presented for 25 samples of metamorphic rocks from the Mid-Bosnian Schist Mts., representing one of the largest allochthonous Palaeozoic terranes incorporated within the Internal Dinarides. Four main age groups can be distinguished: 1) Variscan (∼ 343 Ma), 2) post-Variscan (288-238 Ma), 3) Early Cretaceous (mainly 121-92 Ma), and 4) Eocene (59--35 Ma) ages. Apart from this, an Oligocene (31 Ma) age was obtained on Alpine vein hyalophane. The radiometric dating indicates a polyphase metamorphic evolution of the Palaeozoic formations and suggests a pre-Carboniferous age of the volcano-sedimentary protoliths, an Early Carboniferous age of Variscan metamorphism and deformation, post-Variscan volcanism, an Early Cretaceous metamorphic overprint related to out-of-sequence thrusting of the Palaeozoic complex, and an Eocene and Oligocene metamorphic overprint related to the main Alpine compressional deformation and subsequent strike-slip faulting, and uplift of the metamorphic core. Accordingly, the Mid-Bosnian Schist Mts. can be correlated in its multistage geodynamic evolution with some Palaeozoic tectonostratigraphic units from the Austroalpine domain in the Eastern Alps. (author)

  18. 40Ar/39Ar and K/Ar whole rock age constraints on the timing of regional deformation, South Coast of New South Wales, Lachlan Fold Belt, Southeastern Australia: problems and implications

    International Nuclear Information System (INIS)

    Phillips, D.; Fergusson, C.L.

    1999-01-01

    Full text: Subduction complex rocks are well exposed on the south coast of New South Wales around Batemans Bay. Farther south in the Narooma and Bermagui region, Offier et al (1998) have determined two 40 Ar/ 39 Ar ages of 450 ± 3 Ma and 445 ± 2 Ma. They argued that these ages constrain the timing of intense underplating-related deformation and we have undertaken farther work, from an area south of Batemans Bay, to test this suggestion. The 40 Ar/ 39 Ar method applied to fine-grained, low temperature metamorphic rocks, such as slates, is beset by the problem of recoil loss and/or redistribution of 39 Ar during the irradiation process. Another problem is the difficulty of distinguishing between the contributions to 40 Ar/ 39 Ar spectra from illite/muscovite grown during the cleavage-producing deformation and detrital muscovite/illite. In the current study, four slate samples, with variable contents of detrital white mica, were analysed by both the K-Ar and 40 Ar/ 39 Ar step-heating methods. A separate of detrital white mica from one slate sample yields a plateau age of 500 ± 2 Ma. This result indicates that inheritance has not been eliminated by metamorphism as is commonly assumed and that the 40 Ar/ 39 Ar ages provide only a maximum estimate for the timing of deformation. 40 Ar/ 39 Ar analyses of state chips yield discordant, saddle-shaped age spectra, with minimum, within-saddle' ages of ca. 420 Ma. Two slate samples give identical 40 Ar/ 39 Ar integrated ages of 455 ± 2 Ma. One sample contains relatively abundant detrital bedding-parallel mica flakes that are locally oblique to the regional cleavage in the rock. The 40 Ar/ 39 Ar ages are some 20 Ma older than K-Ar ages for these same samples, suggesting that recoil loss of 39 Ar may also have affected these slates. Both recoil loss of 39 Ar and inherited white micas will yield elevated apparent ages, thus providing only maximum ages for the cleavage-producing deformation. Two other samples from slaty tectonic

  19. Skin scoring in systemic sclerosis

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis...... (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score...

  20. 40Ar/ 39Ar and paleomagnetic results from Liberia and the Precambrian APW data base for the West African Shield

    Science.gov (United States)

    Onstott, T. C.; Dorbor, J.

    Lower amphibolite to granulite facies metamorphic rocks in Nimba County, Liberia have yielded 2.2-2.9 Ga RbSr whole rock ages, indicating that they are part of the Archean Liberian age province. We report a 2040 Ma 4040Ar/ 39Ar plateau date on hornblende from an amphibolite in this region, and suggest that these rocks were also severelyreworked during the Eburnean (˜2.0 Ga) metamorphic episode. 40Ar/ 39Ar analyses of biotite and feldspars from neighboring schists also indicate the presence of two mild thermal events, at 1.5 Ga and 0.6 Ga. Paleomagnetic analyses of samples from these same metamorphic rocks reveal three components of magnetization. The predominant and most stable component (273°E, 21°N) is considered to have been acquired as a result of pos Eburnean uplift and cooling at ˜ 2.0 Ga, whereas the two less stable components with poles at 235°E, 43°N and 16°E, 36°N, probably correlate with the 1.5 Ga and 0.6 Ga thermal pulses, respectively. Rock units from southern Liberia also yield two secondary magnetizations, one at 247°E, 37°N and the other at 104°E, 5°N, and a 1.5 Ga 40Ar/ 39Ar date on plagioclase. Comparison of the paleomagnetic poles corresponding to the ˜2.0 Ga Eburnean component with published paleomagnetic data for West Africa is not consistent with prior interpretations of the polar wander path for West Africa. Our paleomagnetic data, when compared to poles of comparable age from the Kalahari Shield, still suggest that some form of displacement has occurred between the Kalahari and West African Shields since 2.0 Ga.

  1. Timing of Secondary Hydrothermal Alteration of the Luobusa Chromitites Constrained by Ar/Ar Dating of Chrome Chlorites

    Directory of Open Access Journals (Sweden)

    Wei Guo

    2018-05-01

    Full Text Available Chrome chlorites are usually found as secondary phases formed by hydrothermal alteration of chromite deposits and associated mafic/ultramafic rocks. Here, we report the 40Ar/39Ar age of chrome chlorites separated from the Luobusa massive chromitites which have undergone secondary alteration by CO2-rich hydrothermal fluids. The dating results reveal that the intermediate heating steps (from 4 to 10 of sample L7 generate an age plateau of 29.88 ± 0.42 Ma (MSWD = 0.12, plateau 39Ar = 74.6%, and the plateau data points define a concordant inverse isochron age of 30.15 ± 1.05 Ma (MSWD = 0.08, initial 40Ar/36Ar = 295.8 ± 9.7. The Ar release pattern shows no evidence of later degassing or inherited radiogenic component indicated by an atmospheric intercept, thus representing the age of the hydrothermal activity. Based on the agreement of this hydrothermal age with the ~30 Ma adakitic plutons exposed in nearby regions (the Zedong area, tens of kilometers west Luobusa and the extensive late Oligocene plutonism distributed along the southeastern Gangdese magmatic belt, it is suggested that the hydrothermal fluids are likely related to the ~30 Ma magmatism. The hydrothermal fluid circulation could be launched either by remote plutons (such as the Sangri granodiorite, the nearest ~30 Ma pluton west Luobusa or by a similar coeval pluton in the local Luobusa area (inferred, not found or reported so far. Our results provide important clues for when the listwanites in Luobusa were formed.

  2. Astronomically calibrated 40Ar/39Ar age for the Toba supereruption and global synchronization of late Quaternary records

    Science.gov (United States)

    Storey, Michael; Roberts, Richard G.; Saidin, Mokhtar

    2012-11-01

    The Toba supereruption in Sumatra, ∼74 thousand years (ka) ago, was the largest terrestrial volcanic event of the Quaternary. Ash and sulfate aerosols were deposited in both hemispheres, forming a time-marker horizon that can be used to synchronize late Quaternary records globally. A precise numerical age for this event has proved elusive, with dating uncertainties larger than the millennial-scale climate cycles that characterized this period. We report an astronomically calibrated 40Ar/39Ar age of 73.88 ± 0.32 ka (1σ, full external errors) for sanidine crystals extracted from Toba deposits in the Lenggong Valley, Malaysia, 350 km from the eruption source and 6 km from an archaeological site with stone artifacts buried by ash. If these artifacts were made by Homo sapiens, as has been suggested, then our age indicates that modern humans had reached Southeast Asia by ∼74 ka ago. Our 40Ar/39Ar age is an order-of-magnitude more precise than previous estimates, resolving the timing of the eruption to the middle of the cold interval between Dansgaard-Oeschger events 20 and 19, when a peak in sulfate concentration occurred as registered by Greenland ice cores. This peak is followed by a ∼10 °C drop in the Greenland surface temperature over ∼150 y, revealing the possible climatic impact of the eruption. Our 40Ar/39Ar age also provides a high-precision calibration point for other ice, marine, and terrestrial archives containing Toba sulfates and ash, facilitating their global synchronization at unprecedented resolution for a critical period in Earth and human history beyond the range of 14C dating.

  3. arXiv Radiation resistant LGAD design

    CERN Document Server

    Ferrero, M.; Boscardin, M.; Cartiglia, N.; Dalla Betta, G.F.; Galloway, Z.; Mandurrino, M.; Mazza, S.; Paternoster, G.; Ficorella, F.; Pancheri, L.; Sadrozinski, H-F W.; Sola, V.; Staiano, A.; Seiden, A.; Zhao, Y.

    In this paper, we report on the radiation resistance of 50-micron thick LGAD detectors manufactured at the Fondazione Bruno Kessler employing several different doping combinations of the gain layer. LGAD detectors with gain layer doping of Boron, Boron low-diffusion, Gallium, Carbonated Boron and Carbonated Gallium have been designed and successfully produced. These sensors have been exposed to neutron fluences up to $\\phi_n \\sim 3 \\cdot 10^{16}\\; n/cm^2$ and to proton fluences up to $\\phi_p \\sim 9\\cdot10^{15}\\; p/cm^2$ to test their radiation resistance. The experimental results show that Gallium-doped LGADs are more heavily affected by initial acceptor removal than Boron-doped LGAD, while the presence of Carbon reduces initial acceptor removal both for Gallium and Boron doping. Boron low-diffusion shows a higher radiation resistance than that of standard Boron implant, indicating a dependence of the initial acceptor removal mechanism upon the implant width. This study also demonstrates that proton irradiati...

  4. Spectra of Th/Ar and U/Ne hollow cathode lamps for spectrograph calibration

    Science.gov (United States)

    Nave, Gillian; Shlosberg, Ariel; Kerber, Florian; Den Hartog, Elizabeth; Neureiter, Bianca

    2018-01-01

    Low-current Th/Ar hollow cathode lamps have long been used for calibration of astronomical spectrographs on ground-based telescopes. Thorium is an attractive element for calibration as it has a single isotope, has narrow spectral lines, and has a dense spectrum covering the whole of the visible region. However, the high density of the spectrum that makes it attractive for calibrating high-resolution spectrographs is a detriment for lower resolution spectrographs and this is not obvious by examination of existing linelists. In addition, recent changes in regulations regarding the handling of thorium have led to a degradation in the quality of Th/Ar calibration lamps, with contamination by molecular ThO lines that are strong enough to obscure the calibration lines of interest.We are pursuing two approaches to these problems. First, we have expanded and improved the NIST Standard Reference Database 161, "Spectrum of Th-Ar Hollow Cathode Lamps" to cover the region 272 nm to 5500 nm. Spectra of hollow cathode lamps at up to 3 different currents can now be displayed simultaneously. Interactive zooming and the ability to convolve any of the spectra with a Gaussian or uploaded instrument profile enable the user to see immediately what the spectrum would look like at the particular resolution of their spectrograph. Second, we have measured the spectrum of a recent, contaminated Th/Ar hollow cathode lamp using a high-resolution Echelle spectrograph (Madison Wisconsin) at a resolving power (R~ 250,000). This significantly exceeds the resolving power of most astronomical spectrographs and resolves many of the molecular lines of ThO. With these spectra we are measuring and calibrating the positions of these molecular lines in order to make them suitable for spectrograph calibration.In the near infrared region, U/Ne hollow cathode lamps give a higher density of calibration lines than Th/Ar lamps and will be implemented on the upgraded CRIRES+ spectrograph on ESO’s Very Large

  5. Sway Area and Velocity Correlated With MobileMat Balance Error Scoring System (BESS) Scores.

    Science.gov (United States)

    Caccese, Jaclyn B; Buckley, Thomas A; Kaminski, Thomas W

    2016-08-01

    The Balance Error Scoring System (BESS) is often used for sport-related concussion balance assessment. However, moderate intratester and intertester reliability may cause low initial sensitivity, suggesting that a more objective balance assessment method is needed. The MobileMat BESS was designed for objective BESS scoring, but the outcome measures must be validated with reliable balance measures. Thus, the purpose of this investigation was to compare MobileMat BESS scores to linear and nonlinear measures of balance. Eighty-eight healthy collegiate student-athletes (age: 20.0 ± 1.4 y, height: 177.7 ± 10.7 cm, mass: 74.8 ± 13.7 kg) completed the MobileMat BESS. MobileMat BESS scores were compared with 95% area, sway velocity, approximate entropy, and sample entropy. MobileMat BESS scores were significantly correlated with 95% area for single-leg (r = .332) and tandem firm (r = .474), and double-leg foam (r = .660); and with sway velocity for single-leg (r = .406) and tandem firm (r = .601), and double-leg (r = .575) and single-leg foam (r = .434). MobileMat BESS scores were not correlated with approximate or sample entropy. MobileMat BESS scores were low to moderately correlated with linear measures, suggesting the ability to identify changes in the center of mass-center of pressure relationship, but not higher-order processing associated with nonlinear measures. These results suggest that the MobileMat BESS may be a clinically-useful tool that provides objective linear balance measures.

  6. Geochronological 40Ar/39Ar data on the submarine fault-scarps in the Sardinia channel (western mediterranean)

    International Nuclear Information System (INIS)

    Bouillin, J.P.; Tricart, P.; Mascle, G.; Monie, P.; Rolfo, F.; Torelli, L.

    1999-01-01

    Granite and gneiss have been sampled on the submarine fault scarps of the Sardinia Channel and have been dated using the 40 Ar/ 39 Ar method. The majority of rocks partially preserve Hercynian ages. Some of them display Lower Cretaceous ages. In addition, Upper Eocene-Oligocene argon resetting is recorded only in rocks from the southeast sector of the Channel. We thus propose that the basement of the Sardinia Channel occupied a shallow position within the stack of the Alpine tectonic units, behind the more deformed front of the internal zones of the Maghrebide Chain. (authors)

  7. Absolute total and one and two electron transfer cross sections for Ar8+ on Ar as a function of energy

    International Nuclear Information System (INIS)

    Vancura, J.; Kostroun, V.O.

    1992-01-01

    The absolute total and one and two electron transfer cross sections for Ar 8+ on Ar were measured as a function of projectile laboratory energy from 0.090 to 0.550 keV/amu. The effective one electron transfer cross section dominates above 0.32 keV/amu, while below this energy, the effective two electron transfer starts to become appreciable. The total cross section varies by a factor over the energy range explored. The overall error in the cross section measurement is estimated to be ± 15%

  8. A scoring system for ascertainment of incident stroke; the Risk Index Score (RISc).

    Science.gov (United States)

    Kass-Hout, T A; Moyé, L A; Smith, M A; Morgenstern, L B

    2006-01-01

    The main objective of this study was to develop and validate a computer-based statistical algorithm that could be translated into a simple scoring system in order to ascertain incident stroke cases using hospital admission medical records data. The Risk Index Score (RISc) algorithm was developed using data collected prospectively by the Brain Attack Surveillance in Corpus Christi (BASIC) project, 2000. The validity of RISc was evaluated by estimating the concordance of scoring system stroke ascertainment to stroke ascertainment by physician and/or abstractor review of hospital admission records. RISc was developed on 1718 randomly selected patients (training set) and then statistically validated on an independent sample of 858 patients (validation set). A multivariable logistic model was used to develop RISc and subsequently evaluated by goodness-of-fit and receiver operating characteristic (ROC) analyses. The higher the value of RISc, the higher the patient's risk of potential stroke. The study showed RISc was well calibrated and discriminated those who had potential stroke from those that did not on initial screening. In this study we developed and validated a rapid, easy, efficient, and accurate method to ascertain incident stroke cases from routine hospital admission records for epidemiologic investigations. Validation of this scoring system was achieved statistically; however, clinical validation in a community hospital setting is warranted.

  9. The persistence of depression score

    NARCIS (Netherlands)

    Spijker, J.; de Graaf, R.; Ormel, J.; Nolen, W. A.; Grobbee, D. E.; Burger, H.

    2006-01-01

    Objective: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. Method: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R.

  10. Score distributions in information retrieval

    NARCIS (Netherlands)

    Arampatzis, A.; Robertson, S.; Kamps, J.

    2009-01-01

    We review the history of modeling score distributions, focusing on the mixture of normal-exponential by investigating the theoretical as well as the empirical evidence supporting its use. We discuss previously suggested conditions which valid binary mixture models should satisfy, such as the

  11. Developing Scoring Algorithms (Earlier Methods)

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  12. Collisional excitation of ArH+ by hydrogen atoms

    Science.gov (United States)

    Dagdigian, Paul J.

    2018-06-01

    The rotational excitation of the 36ArH+ ion in collisions with hydrogen atoms is investigated in this work. The potential energy surface (PES) describing the 36ArH+-H interaction, with the ion bond length r fixed at the average of r over the radial v = 0 vibrational state distribution, was obtained with a coupled cluster method that included single, double, and (perturbatively) triple excitations [RCCSD(T)]. A deep minimum (De = 3135 cm-1) in the PES was found in linear H-ArH+ geometry at an ion-atom separation Re = 4.80a0. Energy-dependent cross-sections and rate coefficients as a function of temperature for this collision pair were computed in close-coupling (CC) calculations. Since the PES possesses a deep well, this is a good system to test the performance of the quantum statistical (QS) method developed by Manolopoulos and co-workers as a more efficient method to compute the cross-sections. Good agreement was found between rate coefficients obtained by the CC and QS methods at several temperatures. In a simple application, the excitation of ArH+ is simulated for conditions under which this ion is observed in absorption.

  13. Precision lifetime measurements of Ar II 4p doublet levels

    International Nuclear Information System (INIS)

    Marger, D.; Schmoranzer, H.

    1990-01-01

    The lifetimes of the Ar II 4p doublet fine-structure levels 4p 2 D 0 5/2 , 4p' 2 F 0 5/2 and 4p' 2 F 0 7/2 were measured by beam-dye laser spectroscopy. The experimental uncertainty was reduced to below 1%. (orig.)

  14. Professor Oberth and Dr. von Braun at ARS Banquet

    Science.gov (United States)

    1961-01-01

    Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

  15. Plasma based Ar+ beam assisted poly(dimethylsiloxane) surface modification

    International Nuclear Information System (INIS)

    Vladkova, T.G.; Keranov, I.L.; Dineff, P.D.; Youroukov, S.Y.; Avramova, I.A.; Krasteva, N.; Altankov, G.P.

    2005-01-01

    Plasma based Ar + beam performed in RF (13.56 MHz) low-pressure (200 mTorr) glow discharge (at 100 W, 1200 W and 2500 W) with a serial capacitance was employed for surface modification of poly(dimethylsiloxane) (PDMS) aimed at improvement of its interactions with living cells. The presence of a serial capacitance ensures arise of an ion-flow inside the plasma volume directed toward the treated sample and the vary of the discharge power ensures varied density of the ion-flow. XPS analysis was performed to study the changes in the surface chemical composition of the modified samples and the corresponding changes in the surface energy were monitored by contact angle measurements. We found that plasma based Ar + beam transforms the initially hydrophobic PDMS surface into a hydrophilic one mainly due to a raising of the polar component of the surface tension, this effect being most probably due to an enrichment of the modified surface layer with permanent dipoles of a [SiO x ]-based network and elimination of the original methyl groups. The initial adhesion of human fibroblast cells was studied on the described above plasma based Ar + beam modified and acrylic acid (AA) grafted or not fibronectin (FN) pre-coated or bare surfaces. The cell response seems to be related with the peculiar structure and wettability of the modified PDMS surface layer after plasma based Ar + beam treatment followed or not by AA grafting

  16. A Carbon Cycle Science Update Since IPCC AR-4

    NARCIS (Netherlands)

    Dolman, A.J.; Werf, van der G.R.; Molen, van der M.K.; Ganssen, G.; Erisman, J.W.; Strengers, B.

    2010-01-01

    We review important advances in our understanding of the global carbon cycle since the publication of the IPCC AR4. We conclude that: the anthropogenic emissions of CO2 due to fossil fuel burning have increased up through 2008 at a rate near to the high end of the IPCC emission scenarios; there are

  17. Electron impact ionization of Ar/sup 8 +/

    Energy Technology Data Exchange (ETDEWEB)

    Defrance, P.; Rachafi, S.; Jureta, J.; Meyer, F.; Chantrenne, S.

    1986-01-01

    Absolute electron impact ionization cross-sections have been measured for the Neon-like Ar/sup 8 +/ in the energy range from below the threshold for the metastable state to 2500 eV. No contribution of metastable states is observed. The results are well reproduced by the Distorted Wave Born Approximation. 12 refs., 1 fig.

  18. CARCASS AND MEAT QUALITY OF AFRICANDER Ar{D TERSEY ...

    African Journals Online (AJOL)

    wore not sgnificantlf diffcrent bctw€cn thc fiw typer of stcers. The Jersy oompares ... was determined by a method similar to that of Hill (1966). Muscle samples wcre herted for ... than thc Jerscy croscs (7t ar comparcd to 9Jt). Thc ud- mds with thc ...

  19. The ARS Culture Collection and Developments in Biotechnology

    Science.gov (United States)

    The ARS Culture Collection (NRRL) has played a prominent role in the development of biotechnology since its founding in 1940 when the Northern Regional Research Laboratory opened. Early discoveries included selection of production strains for penicillin, dextran blood extender, xanthan gum and the v...

  20. The Educational Values of Athiyyah ar-Rahman Book

    Directory of Open Access Journals (Sweden)

    Maya Yunita

    2018-04-01

    Full Text Available Athiyyah ar-Rahman is an influential book which written by Muhammad Azhari al-Palembani ibn Abdullah ibn Ahmad or also known as Kemas Azhari (1811-1874. The book was written in 1842 and until today is learned by Islamic community in Palembang. This article tries to elucidate the values of Athiyyah ar-Rahman book from education perspectives. The discourse-historical approach of Reisigl and Wodak (2008 is used to analyze the book. The findings show that Athiyyah ar-Rahman describes six pillars of Islam. The six pillars of Islam are framing three dimensions, including personal dimension, social dimension, and transformative dimension. The personal dimension relates to the core of the education to construct the self of student. The social dimension relates to the visions for harmonizing among humans and between humans and nature. Meanwhile, the transformational dimension relates to the effect of education to solve the problems in human life as well as transform the society. Based on the analysis, the educational values of Athiyyah ar-Rahman could be summarized as follows: religiosity, spirituality, morality, solidarity, tolerance, environmentalism, pragmatism and transformational.

  1. 75 FR 10845 - Arkansas Disaster Number AR-00042

    Science.gov (United States)

    2010-03-09

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12034 and 12035] Arkansas Disaster Number AR-00042 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  2. 76 FR 35937 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-06-20

    ... U.S. SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 6. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR...

  3. 76 FR 36953 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 7. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...

  4. 76 FR 36952 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  5. 76 FR 29284 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-05-20

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  6. 76 FR 33394 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-06-08

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...

  7. 76 FR 33807 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-06-09

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  8. 76 FR 35262 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-06-16

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...

  9. 78 FR 13742 - Arkansas Disaster Number AR-00061

    Science.gov (United States)

    2013-02-28

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13473 and 13474] Arkansas Disaster Number AR-00061 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of ARKANSAS...

  10. 76 FR 30226 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-05-24

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...

  11. 76 FR 35262 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-06-16

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 4. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  12. 76 FR 36954 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 6. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  13. 76 FR 41553 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-07-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 7. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  14. 76 FR 28842 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-05-18

    ... SMALL BUSINESS ADMINISTRATION Disaster Declaration 12560 and 12561 Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), 05/02/2011...

  15. 76 FR 30227 - Arkansas Disaster Number AR-00049

    Science.gov (United States)

    2011-05-24

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12562 and 12563] Arkansas Disaster Number AR-00049 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Arkansas...

  16. 76 FR 28843 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-05-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR), dated 05/02...

  17. 76 FR 38717 - Arkansas Disaster Number AR-00048

    Science.gov (United States)

    2011-07-01

    ... U.S. SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12560 and 12561] Arkansas Disaster Number AR-00048 AGENCY: U.S. Small Business Administration. ACTION: Amendment 8. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Arkansas (FEMA-1975-DR...

  18. Nano-hardness estimation by means of Ar+ ion etching

    International Nuclear Information System (INIS)

    Bartali, R.; Micheli, V.; Gottardi, G.; Vaccari, A.; Safeen, M.K.; Laidani, N.

    2015-01-01

    When the coatings are in nano-scale, the mechanical properties cannot be easily estimated by means of the conventional methods due to: tip shape, instrument resolution, roughness, and substrate effect. In this paper, we proposed a semi-empirical method to evaluate the mechanical properties of thin films based on the sputtering rate induced by bombardment of Ar + ion. The Ar + ion bombardment was induced by ion gun implemented in Auger electron spectroscopy (AES). This procedure has been applied on a series of coatings with different structure (carbon films) and a series of coating with a different density (ZnO thin films). The coatings were deposited on Silicon substrates by RF sputtering plasma. The results show that, as predicted by Insepov et al., there is a correlation between hardness and sputtering rate. Using reference materials and a simple power law equation the estimation of the nano-hardness using an Ar + beam is possible. - Highlights: • ZnO film and Carbon films were grown on silicon using PVD. • The growth temperature was room temperature. • The hardness of the coatings was estimated by means of nanoindentation. • Evaluation of resistance of materials to the mechanical damage induced by an Ar + ion gun (AES). • The hardness have been studied and a power law with the erosion rate has been found

  19. Pulsed electric field (PEF)research at USDA, ARS, ERRC

    Science.gov (United States)

    This article summarizes the effects of pulsed electric fields on the microbiological safety and quality aspects of various liquid food matrices, obtained at USDA, ARS, Eastern Regional Research Center under CRIS Project No. 1935-41420-013-00D, Processing Intervention Technologies for Enhancing the S...

  20. Fragmentations of 40Ar at 213 MeV/nucleon

    International Nuclear Information System (INIS)

    Viyogi, Y.P.; Symons, T.J.M.; Doll, P.; Greiner, D.E.; Heckman, H.H.; Hendrie, D.L.; Lindstrom, P.J.; Mahoney, J.; Scott, D.K.; Van Bibber, K.; Westfall, G.D.; Wieman, H.; Crawford, H.J.; McParland, C.; Gelbke, C.K.

    1979-01-01

    Energy and isotope distributions were measured for peripheral reactions induced by 40 Ar at 213 MeV/nucleon. The data are consistent with the predictions of abrasion-ablation models. The influence of correlations in the nuclear ground state is discussed

  1. Modification of van La ar activity coefficient model

    International Nuclear Information System (INIS)

    Vakili-Nezhaad, G. R.; Modarress, H.; Mansoori, G. A.

    2001-01-01

    Based on statistical and mechanical arguments, the original van La ar activity coefficient model has been improved by reasonable assumptions. This modifications has been done by replacing the van der Waals equation of state with the Redlich-K wong equation of state in the formulation of van La ar with consistent mixing rules for the energy and volume parameters of this equation of state (a mix , b mix ). Other equations of state, such as the Soave modification of the Redlich-K wong equation of state, P eng-Robinson and Mohsen-Nia, Modarress and Mansoori equations of state, have been introduced in the formulation of van La ar for the activity coefficients of the components present in the binary liquid mixtures, and their effects on the accuracy of the resultant activity coefficient models have been examined. The results of these revised models have been compared with the experimental data and it was found that the Redlich-K wong equation of state with the van der Waals mixing rules for the volume and energy parameters of this equation, is the best choice among these equations of state. In addition, it can improve the original van La ar activity coefficient model and, therefore a better agreement with the experimental data is obtained

  2. 244-AR vault cooling water stream-specific report

    International Nuclear Information System (INIS)

    1990-08-01

    The proposed wastestream designation for the 244-AR Vault cooling water wastestream is that this stream is not a dangerous waste, pursuant to the Washington (State) Administration Code (WAC) 173-303, Dangerous Waste Regulations. A combination of process knowledge and sampling data was used to make this determination. 21 refs., 6 figs., 7 tabs

  3. Data management and database structure at the ARS Culture Collection

    Science.gov (United States)

    The organization and management of collection data for the 96,000 strains held in the ARS Culture Collection has been an ongoing process. Originally, the records for the four separate collections were maintained by individual curators in notebooks and/or card files and subsequently on the National C...

  4. Ars Fennica - isikliku ja poliitilise vahel / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-

    2009-01-01

    2008. aasta Ars Fennica kunstiauhinna kandidaatide tööde näitus Kumu Kunstimuuseumis kuni 26. aprillini. Läti kunstniku Katrina Neiburga, soomlaste Seppo Renvalli, Maria Dunckeri ja Tea Mäkipää ning Mark Raidpere näitusel eksponeeritud töödest

  5. Big data computing: Building a vision for ARS information management

    Science.gov (United States)

    Improvements are needed within the ARS to increase scientific capacity and keep pace with new developments in computer technologies that support data acquisition and analysis. Enhancements in computing power and IT infrastructure are needed to provide scientists better access to high performance com...

  6. Immune epitope database analysis resource (IEDB-AR)

    DEFF Research Database (Denmark)

    Zhang, Qing; Wang, Peng; Kim, Yohan

    2008-01-01

    We present a new release of the immune epitope database analysis resource (IEDB-AR, http://tools.immuneepitope.org), a repository of web-based tools for the prediction and analysis of immune epitopes. New functionalities have been added to most of the previously implemented tools, and a total...

  7. Microarea dating of mineral and rock. The application of technique by combining 40Ar/39Ar mass spectrometer with laser probe

    International Nuclear Information System (INIS)

    Hu Shiling; Dai Tongmo; Pu Zhiping

    1998-01-01

    The 40 Ar/ 39 Ar dating of probe technique by the continuous laser is successfully applied to determine the ages of microarea samples for mineral and whole rock, including the standard samples from internal and abroad, volcanical rock from westsouthern Antarctica and Green Pissolites of Guizhou. Isochron ages for volcanical rock to be excess or lost argon are accomplished by the whole fused, and for 'green Pisolites' not only by the whole fused, but also by the steps heat. All of which shows the significant geological ages. It would be exhibited the obvious advantage for dating some special samples to make the microarea 40 Ar/ 39 Ar dating technique by laser probe as compare with conventional K-Ar and 40 Ar/ 39 Ar methods

  8. Behaviour of AR glass fibre for building structural applications

    Directory of Open Access Journals (Sweden)

    Miravete, A.

    2005-12-01

    Full Text Available The AR glass reinforcement fibres were designed to resist the alkalis from the concrete. This is the main reason for its utilisation as a short-fibre-reinforcement of mortar and concrete for the last decades. Originally, the AR glass fibre sizing was not compatible with synthetic resins, so that this type of reinforcement was applied exclusively to mortar and concrete matrices. Recently, due to the developments of sizing, which are compatible with synthetic resins, the AR- glass fibres may be used as reinforcement of organic matrix composite materials, broadening the range of structural applications. The mechanical properties of AR glass fibre and organic matrix composite materials will be studied in this paper. First, the behaviour of this material under stress corrosion will be analysed. Their mass loss will be compared to E, C, and boron free glass fibres. Second, an experimental study dealing with 3P test bending and short beam ofAR glass fibre/polyester will de described with the goal of obtaining their Young modulus and tensile and interlaminar shear strengths. Finally, these experimental results will be compared to E glass fibre/polyester and several conclusions about their structural applications will be drawn.

    El vidrio AR y su presentación en forma de fibras de refuerzo, fue diseñado para ser inerte a los álcalis de los cementos. Por este motivo se viene utilizando desde hace varias décadas como refuerzo de morteros y hormigones en forma de fibra corta. El ensimaje que estas fibras de vidrio de refuerzo A R presentaba en su origen no era compatible con resinas de tipo sintéticas, por lo que el refuerzo era exclusivo para cementos y hormigones fuera cual fuera la aplicación, formato o proceso productivo. Recientemente, gracias al desarrollo específico de ensimajes especiales acordes a las fibras de vidrio AR ha aparecido la misma tipología de vidrio AR como refuerzo en forma de fibra continua compatible con resinas sint

  9. Crude oil He and Ar isotopic characteristics and their geochemical significance: an example from the Gangxi oil field in the Huanghua depression

    Directory of Open Access Journals (Sweden)

    S. Chenpeng

    2005-06-01

    Full Text Available Sampled from the Gangxi oil field in the Huanghua depression, Bohaiwan Basin, the crude oil He and Ar isotopic compositions and their geochemical significance were investigated. The result shows that i the 3He/4He values of the six oil samples free from air contamination indicate a mantle helium contribution ranging between 13.9% and 32.8% and averaging 24.1%, which means that the Gangxi oil field once had a tectonic background of the mantle-derived helium input and higher geothermal flow with an average of 75.0 mWm-2; ii deduced from the 40Ar/36Ar aging effect the Gangxi oil should be derived from the Tertiary; iii water injection is the main reason for the air contamination for the Gangxi oil noble gases and the relations between 3He/4He and 4He/20Ne as well as 40Ar/36Ar and 4He/20Ne are of an applicative potential in estimating the water injection effect and the connectivity of producing formations. The search for the crude oil He and Ar isotopes provides a new approach to inferring natural gas and oil sources, tectonic backgrounds, geothermal flow and water injection effect.

  10. Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats [Skaane University Hospital, Lund University, Centre for Medical Imaging and Physiology, Lund (Sweden); Hoeglund, Peter [Skaane University Hospital, Competence Centre for Clinical Research, Lund (Sweden)

    2012-12-15

    To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

  11. Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis.

    Science.gov (United States)

    Vult von Steyern, Kristina; Björkman-Burtscher, Isabella M; Höglund, Peter; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats

    2012-12-01

    To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. Tomosynthesis is more sensitive than conventional radiography for pulmonary cystic fibrosis changes. The radiation dose from chest tomosynthesis is low compared with computed tomography. Tomosynthesis may become useful in the regular follow-up of patients with cystic fibrosis.

  12. Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis

    International Nuclear Information System (INIS)

    Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats; Hoeglund, Peter

    2012-01-01

    To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

  13. Epistaxis grading in Osler's disease: comparison of comprehensive scores with detailed bleeding diaries.

    Science.gov (United States)

    Parzefall, Thomas; Wolf, Axel; Frei, Klemens; Kaider, Alexandra; Riss, Dominik

    2017-03-01

    Use of reliable grading scores to measure epistaxis severity in hereditary hemorrhagic telangiectasia (HHT) is essential in clinical routine and for scientific purposes. For practical reasons, visual analog scale (VAS) scoring and the Epistaxis Severity Score (ESS) are widely used. VAS scores are purely subjective, and a potential shortcoming of the ESS is that it is based on self-reported anamnestic bleeding data. The aim of this study was to validate the level of correlation between VAS scores, the ESS, and actual bleeding events, based on detailed epistaxis diaries of patients. Records from daily epistaxis diaries maintained by 16 HHT patients over 112 consecutive days were compared with the monthly ESS and daily VAS scores in the corresponding time period. The Spearman rank correlation coefficient, analysis of variance models, and multiple R 2 measures were used for statistical analysis. Although the ESS and VAS scores generally showed a high degree of correlation with actual bleeding events, mild events were underrepresented in both scores. Our results highlight the usefulness of the ESS as a standard epistaxis score in cohorts with moderate to severe degrees of epistaxis. The use of detailed epistaxis diaries should be considered when monitoring patients and cohorts with mild forms of HHT. © 2016 ARS-AAOA, LLC.

  14. Precision angle-resolved autoionization resonances in Ar and Ne

    Energy Technology Data Exchange (ETDEWEB)

    Berrah, N.; Langer, B.; Gorczyca, T.W. [Western Michigan Univ., Kalamazoo, MI (United States)] [and others

    1997-04-01

    Theoretical work has shown that the electron angular distribution and the shape of the autoionization resonances are crucial to the understanding of certain types of electron-electron correlation. Autoionization resonances in Ne (Ar) result from the decay of the excited discrete state Ne{sup *} 2s2p{sup 6} np (Ar{sup *} 3s3p{sup 6} np) into the continuum state Ne{sup +} 2s{sup 2}2p{sup 5} + e{sup {minus}} (ks,kd) (Ar{sup +} 3s{sup 2}3p{sup 5} + e{sup {minus}} (ks,kd)). Since the continuum can also be reached by direct photoionization, both paths add coherently, giving rise to interferences that produce the characteristic Beutler-Fano line shape. In this work, the authors report on quantitative angle-resolved electron spectrometry studies of (a) the Ne 2s{sup 2}2p{sup 6} {r_arrow} 2s2p{sup 6} np (n=3-5) autoionizing resonances and the 2s{sup 2}2p{sup 6} {r_arrow} 2p{sup 4}3s3p doubly excited resonance, (b) the Ar 3s{sup 2}3p{sup 6} {r_arrow} 3s3p{sup 6} np (n=4-9) autoionization resonances and extended R-matrix calculations of the angular-distribution parameters for both Ne and Ar measurements. Their results are compared with previous theoretical work by Taylor.

  15. The AR Sandbox: Augmented Reality in Geoscience Education

    Science.gov (United States)

    Kreylos, O.; Kellogg, L. H.; Reed, S.; Hsi, S.; Yikilmaz, M. B.; Schladow, G.; Segale, H.; Chan, L.

    2016-12-01

    The AR Sandbox is a combination of a physical box full of sand, a 3D (depth) camera such as a Microsoft Kinect, a data projector, and a computer running open-source software, creating a responsive and interactive system to teach geoscience concepts in formal or informal contexts. As one or more users shape the sand surface to create planes, hills, or valleys, the 3D camera scans the surface in real-time, the software creates a dynamic topographic map including elevation color maps and contour lines, and the projector projects that map back onto the sand surface such that real and projected features match exactly. In addition, users can add virtual water to the sandbox, which realistically flows over the real surface driven by a real-time fluid flow simulation. The AR Sandbox can teach basic geographic and hydrologic skills and concepts such as reading topographic maps, interpreting contour lines, formation of watersheds, flooding, or surface wave propagation in a hands-on and explorative manner. AR Sandbox installations in more than 150 institutions have shown high audience engagement and long dwell times of often 20 minutes and more. In a more formal context, the AR Sandbox can be used in field trip preparation, and can teach advanced geoscience skills such as extrapolating 3D sub-surface shapes from surface expression, via advanced software features such as the ability to load digital models of real landscapes and guiding users towards recreating them in the sandbox. Blueprints, installation instructions, and the open-source AR Sandbox software package are available at http://arsandbox.org .

  16. Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.

    Directory of Open Access Journals (Sweden)

    Adriana Monserrath Orellana-Paucar

    Full Text Available In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ. In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar-turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar-turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf] in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.

  17. Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.

    Science.gov (United States)

    Orellana-Paucar, Adriana Monserrath; Afrikanova, Tatiana; Thomas, Joice; Aibuldinov, Yelaman K; Dehaen, Wim; de Witte, Peter A M; Esguerra, Camila V

    2013-01-01

    In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar-turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar-turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.

  18. AR-NE3A, a New Macromolecular Crystallography Beamline for Pharmaceutical Applications at the Photon Factory

    International Nuclear Information System (INIS)

    Yamada, Yusuke; Hiraki, Masahiko; Sasajima, Kumiko; Matsugaki, Naohiro; Igarashi, Noriyuki; Kikuchi, Takashi; Mori, Takeharu; Toyoshima, Akio; Kishimoto, Shunji; Wakatsuki, Soichi; Amano, Yasushi; Warizaya, Masaichi; Sakashita, Hitoshi

    2010-01-01

    Recent advances in high-throughput techniques for macromolecular crystallography have highlighted the importance of structure-based drug design (SBDD), and the demand for synchrotron use by pharmaceutical researchers has increased. Thus, in collaboration with Astellas Pharma Inc., we have constructed a new high-throughput macromolecular crystallography beamline, AR-NE3A, which is dedicated to SBDD. At AR-NE3A, a photon flux up to three times higher than those at existing high-throughput beams at the Photon Factory, AR-NW12A and BL-5A, can be realized at the same sample positions. Installed in the experimental hutch are a high-precision diffractometer, fast-readout, high-gain CCD detector, and sample exchange robot capable of handling more than two hundred cryo-cooled samples stored in a Dewar. To facilitate high-throughput data collection required for pharmaceutical research, fully automated data collection and processing systems have been developed. Thus, sample exchange, centering, data collection, and data processing are automatically carried out based on the user's pre-defined schedule. Although Astellas Pharma Inc. has a priority access to AR-NE3A, the remaining beam time is allocated to general academic and other industrial users.

  19. Multiple Score Comparison: a network meta-analysis approach to comparison and external validation of prognostic scores

    Directory of Open Access Journals (Sweden)

    Sarah R. Haile

    2017-12-01

    Full Text Available Abstract Background Prediction models and prognostic scores have been increasingly popular in both clinical practice and clinical research settings, for example to aid in risk-based decision making or control for confounding. In many medical fields, a large number of prognostic scores are available, but practitioners may find it difficult to choose between them due to lack of external validation as well as lack of comparisons between them. Methods Borrowing methodology from network meta-analysis, we describe an approach to Multiple Score Comparison meta-analysis (MSC which permits concurrent external validation and comparisons of prognostic scores using individual patient data (IPD arising from a large-scale international collaboration. We describe the challenges in adapting network meta-analysis to the MSC setting, for instance the need to explicitly include correlations between the scores on a cohort level, and how to deal with many multi-score studies. We propose first using IPD to make cohort-level aggregate discrimination or calibration scores, comparing all to a common comparator. Then, standard network meta-analysis techniques can be applied, taking care to consider correlation structures in cohorts with multiple scores. Transitivity, consistency and heterogeneity are also examined. Results We provide a clinical application, comparing prognostic scores for 3-year mortality in patients with chronic obstructive pulmonary disease using data from a large-scale collaborative initiative. We focus on the discriminative properties of the prognostic scores. Our results show clear differences in performance, with ADO and eBODE showing higher discrimination with respect to mortality than other considered scores. The assumptions of transitivity and local and global consistency were not violated. Heterogeneity was small. Conclusions We applied a network meta-analytic methodology to externally validate and concurrently compare the prognostic properties

  20. Walk Score® and Transit Score® and Walking in the Multi-Ethnic Study of Atherosclerosis

    Science.gov (United States)

    Hirsch, Jana A.; Moore, Kari A.; Evenson, Kelly R.; Rodriguez, Daniel A; Diez Roux, Ana V.

    2013-01-01

    Background Walk Score® and Transit Score® are open-source measures of the neighborhood built environment to support walking (“walkability”) and access to transportation. Purpose To investigate associations of Street Smart Walk Score and Transit Score with self-reported transport and leisure walking using data from a large multi-city and diverse population-based sample of adults. Methods Data from a sample of 4552 residents of Baltimore MD; Chicago IL; Forsyth County NC; Los Angeles CA; New York NY; and St. Paul MN from the Multi-Ethnic Study of Atherosclerosis (2010–2012) were linked to Walk Score and Transit Score (collected in 2012). Logistic and linear regression models estimated ORs of not walking and mean differences in minutes walked, respectively, associated with continuous and categoric Walk Score and Transit Score. All analyses were conducted in 2012. Results After adjustment for site, key sociodemographic, and health variables, a higher Walk Score was associated with lower odds of not walking for transport and more minutes/week of transport walking. Compared to those in a “walker’s paradise,” lower categories of Walk Score were associated with a linear increase in odds of not transport walking and a decline in minutes of leisure walking. An increase in Transit Score was associated with lower odds of not transport walking or leisure walking, and additional minutes/week of leisure walking. Conclusions Walk Score and Transit Score appear to be useful as measures of walkability in analyses of neighborhood effects. PMID:23867022

  1. Ar-Ar Ages of Nakhlites Y000593, NWA998, and Nakhla and CRE Age of NWA998.

    Science.gov (United States)

    Garrison, D. H.; Bogard, D. D.

    2006-01-01

    The seven known Martian nakhlites are Nakhla, Lafayette, Governador Valadares, and four recent finds from hot and cold deserts: MIL03346 from the Transantarctic Mountains, a paired group from the Yamato Mountains (Y000593, Y000749, and Y000802; 1), and two from Morocco (NWA998 and NWA817; 2). Radiometric ages (Sm-Nd, Rb-Sr, U-Pb, and Ar-Ar) for the first three nakhlites, along with Chassigny, fall in the range of 1.19-1.37 Gyr and may suggest a common formation age (e.g., 3). These meteorites also show very similar cosmic-ray (space) exposure ages, which suggests a single ejection event from Mars (3). The ages for nakhlites are different from those of Martian shergottites, whose radiometric ages vary by nearly a factor of three (approximately 165-475 Myr) and whose space exposure ages vary over a factor of approximately 20 (3). Shergottite ages suggest that multiple locations on the Martian surface have been sampled, whereas nakhlite data imply that only one Mars surface location has been sampled. Because older Martian surfaces are expected to be more abundant, it seems surprising that all nakhlites would represent only one Martian impact event. To address this issue, we are measuring the Ar-39-Ar-40 ages of Y-000593, NWA-998, Nakhla, and MIL-03346, and the space (CRE) exposure age of NWA998.

  2. Ar-Ar Ages of Nakhlites Y000593, NWA998, and Nakhla and CRE Ages of NWA998

    Science.gov (United States)

    Garrison, D. H.; Bogard, D. D.

    2005-01-01

    The seven known Martian nakhlites are Nakhla, Lafayette, Governador Valadares, and four recent finds from hot and cold deserts: MIL03346 from the Transantarctic Mountains, a paired group from the Yamato Mountains (Y000593, Y000749, and Y000802, and two from Morocco (NWA998 and NWA817. Radiometric ages (Sm-Nd, Rb-Sr, U-Pb, and Ar-Ar) for the first three nakhlites, along with Chassigny, fall in the range of 1.19-1.37 Gyr and may suggest a common formation age. These meteorites also show very similar cosmic-ray (space) exposure ages, suggesting a single ejection event from Mars. The ages for nakhlites are different from those of Martian shergottites, whose radiometric ages vary by nearly a factor of three (approx. 165-475 Myr) and whose space exposure ages vary over a factor of approx. 20. Shergottite ages suggest that multiple locations on the Martian surface have been sampled, whereas nakhlite data imply sampling of only one Mars surface location. Because older Martian surfaces are expected to be more abundant, it seems surprising that all nakhlites would represent only one Martian impact event. To address this issue, we are measuring the (39)Ar-(40)Ar ages of Y-000593, NWA-998, Nakhla, and MIL-03346, and the space (CRE) exposure age of NWA998. Additional information is included in the original extended abstract.

  3. 40Ar/39Ar incremental-release ages of biotite from a progressively remetamorphosed Archean basement terrane in southwestern Labrador

    International Nuclear Information System (INIS)

    Dallmeyer, R.D.

    1982-01-01

    Gneisses within Archean basement terrane adjacent to the southwestern portion of the Labrador Trough were variably retrograded during a regional metamorphism of Grenville age (ca. 1000 Ma). Bioties from non-retrograded segments of the gneiss terrane record 40 Ar/ 39 Ar plateau and isochron ages which date times of cooling following an episode of the Kenoran orogeny (2376-2391 Ma). A suite of gneiss samples displaying varying degrees of retrograde alteration was collected across the Grenville metamorphic gradient. Bioties in these samples show no petrographic evidence of retrograde alteration, however they do record internally discordant 40 Ar/ 39 Ar age spectra. Although the extent of internal discordance is variable, the overall character of the release patterns is similar with younger apparent ages recorded in intermediate-temperature gas fractions. The total-gas dates range from 2257+-27 Ma (northwest) to 1751+-23 Ma (southeast), suggesting that variable quantities of radiogenic argon were lost from the Archean biotites during Grenville metamorphism. The 'saddle-shaped' nature of the discordant spectra indicates that argon loss was not accomplished through single-stage, volume diffusion processes. (orig./ME)

  4. Geochemistry and 40Ar/39Ar age of Early Carboniferous dolerite sills in the southern Baltic Sea

    Directory of Open Access Journals (Sweden)

    Gediminas Motuza

    2015-08-01

    Full Text Available The Early Carboniferous magmatic event in the southern Baltic Sea is manifested by dolerite intrusions. The presumable area in which the dolerite intrusions occur ranges from 30 to 60 km in east–west direction, and is about 100 km in north–south direction. The dolerites were sampled in well D1-1 and investigated by applying chemical analysis and 40Ar/39Ar step-heating dating. Dolerites are classified as alkali and sodic, characterized by high TiO2 (3.92, 3.99 wt% and P2O5 (1.67, 1.77 wt% and low MgO (4.89, 4.91 wt% concentrations, enriched in light rare earth elements, originated from an enriched mantle magma source and emplaced in a continental rift tectonic setting. The 351 ± 11 Ma 40Ar/39Ar plateau age for groundmass plagioclase indicates a considerable age gap with the 310–250 Ma magmatism in southern Scandinavia and northern Germany. The magmatic rocks in the Baltic Sedimentary Basin are coeval with alkaline intrusions of NE Poland. Both magmatic provinces lie in the northwestward prolongation of the Pripyat–Dnieper–Donetsk Rift (370–359 Ma and may constitute a later phase of magmatic activity of this propagating rift system.

  5. Levels in 45K and 46K excited by the β decay of 45Ar and 46Ar

    International Nuclear Information System (INIS)

    Huck, A.; Klotz, G.; Knipper, A.; Miehe, C.; Walter, G.

    1979-01-01

    The nuclides 45 Ar and 46 Ar have been produced by spallation reactions on vanadium targets at Esub(p)=600MeV. The subsequent decays to 45 K and 46 K states have been studied. An intensity of 98.6+-0.6% was measured for the β transition of the 1.94MeV state in 46 K. A decay scheme involving 13 β branches has been established for 45 Ar, and the corresponding log values have been deduced. Eleven states are reported for the first time in the decay scheme of 45 Ar 1.42, 1.47, 1.72, 2.52, 2.57, 2.75, 3.31, 3.99, 4.04, 4.36 and 4.57MeV. From the lifetime, tau=4.6+-0.6ns, deduced from γ-γ delayed coincidences, the angular momentum of the 1081keV level has been established as (7/2) - on the basis of the transition strength of its γ decay. A survey on the 1fsub(7/2)→1dsub(3/2)M2 transition in odd K nuclei is presented and the observed hindrance factors are discussed

  6. Ionization of 0.5 MeV H by Ar and a comparison with the H-/Ar system

    International Nuclear Information System (INIS)

    Duncan, M.M.; Menendez, M.G.

    1979-01-01

    Doubly differential cross sections (DDCS) and the complete angular distributions of electrons released in projectile ionization of H and H - by Ar are compared. These experimental cross sections are also compared to calculations using an elastic scattering model. The angular dependence of the shapes and the peak energies of the DDCS are shown for both systems

  7. I-Xe and 40Ar-39Ar dating of silicate from Weekeroo Station and Netschaevo IIE iron meteorites

    International Nuclear Information System (INIS)

    Niemeyer, S.

    1980-01-01

    Silicate inclusions from two IIE iron meteorites were dated by the I-Xe and 40 Ar- 39 Ar techniques. Weekeroo Station, a 'normal' IIE iron, shows no loss of radiogenic 40 Ar at low temperature, and the well defined 40 Ar- 39 Ar plateau yields an age of 4.54 +- 0.03 Byr. The xenon data define a good I-Xe correlation with an age of + 10.9 +- 0.5 Myr relative to Bjurbole. Despite its relatively young age, Weekeroo Station's ( 129 Xe/ 132 Xe)sub(trapped) ratio (= 0.84 +- 0.05) lies significantly below the solar value. Netschaevo silicate has a chondritic composition, unlike 'normal' IIE silicate which is more differentiated. Nevertheless Netschaevo gives a 40 Ar- 39 Ar plateau-age of only 3.79 +- 0.03 Byr, with the xenon data failing to define an I-Xe isochron. Only irons from the IAB and IIE groups contain silicate inclusions, but these two groups differ in many other respects, mostly suggesting that IAB meteorites are more primitive. The I-Xe chronology supports this suggestion inasmuch as Weekeroo Station formed well after IAB silicates. The four silicate-bearing IIE irons which have now been dated can be subdivided into distinct pairs: Weekeroo Station and Colomera formed near the beginning of the solar system, while Netschaevo and Kodaikanal both formed only 3.8 Byr ago. A review of other properties of these meteorites generally supports this subdivision. This work underscores the complexity of the history of IIE meteorites; in particular, an adequate model must account for the formation of two IIE irons at 3.8 Byr without disturbing rare gases in Weekeroo Station. All formation models are quite speculative, but the one which seems best to fit the available evidence postulates two parent bodies: the 3.8 Byr old silicate formed on one parent body, all other IIE material resided in a separate body, and subsequent collision(s) mixed the young silicate with IIE metal. (author)

  8. 40Ar/39Ar dates in the Central Cordillera of Colombia: Evidence for an upper triassic regional tecnomagmatic event

    International Nuclear Information System (INIS)

    Vinasco, C.J.; Cordani, U.G.; Vasconcelos, P

    2001-01-01

    The Coastal, Western, Central and the Eastern Cordilleras constitute four independent mountain ranges in the Northern Andes. The Coastal and Western Cordillera comprises allochthonous oceanic sequences of basic volcanic rocks and marine sediments of Cenozoic and Upper Cretaceous age (Aspden et al., 1987). The so-called Central Cordillera Polymetamorphic Complex (Restrepo and Toussaint, 1982), made up the pre-Mesozoic Central Cordillera basement, consists of low through high-grade metamorphic rocks intruded by Meso-Cenozoic batholiths. The Eastern Cordillera is a polydeformed continental mountain range consisting of Precambrian and Paleozoic metamorphic and igneous rocks overlain by Paleozoic to Mesozoic sedimentary covers. The northern part of the Central Cordillera has been described as a suspect terrain affected by several tectonometamorphic episodes. The most important of them have been always considered those related to the Hercynian orogeny, in Devonian and Carboniferous times, and those occurring at the beginning of the Andean Cycle in the Cretaceous (Restrepo and Toussaint, 1982). A possible Lower Paleozoic and even Precambrian age for the basement of the terrain has also been proposed. Although some indications of a Permo-Triassic event are already available, this period was not considered as of great importance for the geologic evolution of the region. The available radiometric dates in the 200-250 Ma interval, for the Central Cordillera, are as follows: 1. One K-Ar whole rock age for a Granulite of 251±21 Ma. (Restrepo et al, 1991) of the El Retiro group SE of Medellin. However, a K-Ar biotite age of 110±10 Ma. (Toussaint et al., 1978) was obtained for a migmatite rock associated with the same group. 2. A Sm/Nd garnet and whole rock age of 226±17 Ma in rocks associated to granulites, SE of Medellin, interpreted as metamorphic ages (Correa and Martins, 2001). 3. K-Ar biotite dates for the Puqui metamorphic complex, occurring north of Medellin, ranging

  9. Development of a severity score for CRPS.

    Science.gov (United States)

    Harden, R Norman; Bruehl, Stephen; Perez, Roberto S G M; Birklein, Frank; Marinus, Johan; Maihofner, Christian; Lubenow, Timothy; Buvanendran, Asokumar; Mackey, Sean; Graciosa, Joseph; Mogilevski, Mila; Ramsden, Christopher; Schlereth, Tanja; Chont, Melissa; Vatine, Jean-Jacques

    2010-12-01

    The clinical diagnosis of Complex Regional Pain Syndrome (CRPS) is a dichotomous (yes/no) categorization necessary for clinical decision-making. However, such dichotomous diagnostic categories do not convey an individual's subtle and temporal gradations in severity of the condition, and have poor statistical power when used as an outcome measure in research. This study evaluated the validity and potential utility of a continuous type score to index severity of CRPS. Psychometric and medical evaluations were conducted in 114 CRPS patients and 41 non-CRPS neuropathic pain patients. Based on the presence/absence of 17 clinically-assessed signs and symptoms of CRPS, an overall CRPS Severity Score (CSS) was derived. The CSS discriminated well between CRPS and non-CRPS patients (pCRPS diagnoses using both IASP diagnostic criteria (Eta=0.69) and proposed revised criteria (Eta=0.77-0.88). Higher CSS was associated with significantly higher clinical pain intensity, distress, and functional impairments, as well as greater bilateral temperature asymmetry and thermal perception abnormalities (p'sCRPS, and support its validity as an index of CRPS severity. Its utility as an outcome measure in research studies is also suggested, with potential statistical advantages over dichotomous diagnostic criteria. Copyright © 2010. Published by Elsevier B.V.

  10. The immunohistochemical expression and potential prognostic value of HDAC6 and AR in invasive breast cancer.

    Science.gov (United States)

    Li, Congying; Cao, Lu; Xu, Cong; Liu, Fang; Xiang, Guomin; Liu, Xiaozhen; Jiao, Jiao; Niu, Yun

    2018-05-01

    Previous studies have investigated the role of histone deacetylase 6 (HDAC6) in the regulation of androgen receptor (AR) in prostate cancer; however, the role of HDAC6 has not yet been clearly identified in breast cancer. The aim of this study was to examine the expression of HDAC6 and AR, determine the correlation between HDAC6 and AR, and assess the prognostic value of HDAC6 and AR in breast cancer. A total of 228 cases of invasive breast cancer were randomly selected. The expression of HDAC6 and AR was analyzed by immunohistochemistry. χ 2 Tests were performed to determine the association between conventional clinicopathological factors and HDAC6, AR, and HDAC6/AR co-expression. Spearman correlation methods were performed to determine the correlation between HDAC6 and AR, and Kaplan-Meier analyses were performed to determine the prognostic impact of HDAC6, AR and HDAC6/AR co-expression; 58.8% (134/228) patients exhibited high expression of HDAC6. High HDAC6 expression was significantly associated with high histologic grade (G3) (PAR expression levels were significantly associated (r=0.382, PAR+ groups (PAR and HDAC6 and HDAC6/AR co-expression had a worse clinical prognosis. The expression levels of HDAC6 and AR are correlated in breast cancer; moreover, HDAC6 and AR have prognostic value in predicting the overall survival (OS) of ER-negative breast cancer patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. SOS score: an optimized score to screen acute stroke patients for obstructive sleep apnea.

    Science.gov (United States)

    Camilo, Millene R; Sander, Heidi H; Eckeli, Alan L; Fernandes, Regina M F; Dos Santos-Pontelli, Taiza E G; Leite, Joao P; Pontes-Neto, Octavio M

    2014-09-01

    Obstructive sleep apnea (OSA) is frequent in acute stroke patients, and has been associated with higher mortality and worse prognosis. Polysomnography (PSG) is the gold standard diagnostic method for OSA, but it is impracticable as a routine for all acute stroke patients. We evaluated the accuracy of two OSA screening tools, the Berlin Questionnaire (BQ), and the Epworth Sleepiness Scale (ESS) when administered to relatives of acute stroke patients; we also compared these tools against a combined screening score (SOS score). Ischemic stroke patients were submitted to a full PSG at the first night after onset of symptoms. OSA severity was measured by apnea-hypopnea index (AHI). BQ and ESS were administered to relatives of stroke patients before the PSG and compared to SOS score for accuracy and C-statistics. We prospectively studied 39 patients. OSA (AHI ≥10/h) was present in 76.9%. The SOS score [area under the curve (AUC): 0.812; P = 0.005] and ESS (AUC: 0.789; P = 0.009) had good predictive value for OSA. The SOS score was the only tool with significant predictive value (AUC: 0.686; P = 0.048) for severe OSA (AHI ≥30/h), when compared to ESS (P = 0.119) and BQ (P = 0.191). The threshold of SOS ≤10 showed high sensitivity (90%) and negative predictive value (96.2%) for OSA; SOS ≥20 showed high specificity (100%) and positive predictive value (92.5%) for severe OSA. The SOS score administered to relatives of stroke patients is a useful tool to screen for OSA and may decrease the need for PSG in acute stroke setting. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Combining Teacher Assessment Scores with External Examination ...

    African Journals Online (AJOL)

    Combining Teacher Assessment Scores with External Examination Scores for Certification: Comparative Study of Four Statistical Models. ... University entrance examination scores in mathematics were obtained for a subsample of 115 ...

  13. Scoring System Improvements to Three Leadership Predictors

    National Research Council Canada - National Science Library

    Dela

    1997-01-01

    .... The modified scoring systems were evaluated by rescoring responses randomly selected from the sample which had been scored according to the scoring systems originally developed for the leadership research...

  14. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Steinert

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  15. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Vincent P. Coletta

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292, and strong, positive correlations were found for both populations (r=0.57 and r=0.46, respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  16. Blind Grid Scoring Record No. 290

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  17. Blind Grid Scoring Record No. 293

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George; Archiable, Robert; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  18. Open Field Scoring Record No. 298

    National Research Council Canada - National Science Library

    Overbay, Jr., Larry; Robitaille, George; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  19. Open Field Scoring Record No. 299

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the standardized UXO Technology Demonstration Site Scoring Committee...

  20. Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance.

    Science.gov (United States)

    Rajan, Sujith; Satish, Sabbu; Shankar, Kripa; Pandeti, Sukanya; Varshney, Salil; Srivastava, Ankita; Kumar, Durgesh; Gupta, Abhishek; Gupta, Sanchita; Choudhary, Rakhi; Balaramnavar, Vishal M; Narender, Tadigoppula; Gaikwad, Anil N

    2018-03-07

    In our drug discovery program of natural product, earlier we have reported Aegeline that is N-acylated-1-amino-2- alcohol, which was isolated from the leaves of Aeglemarmelos showed anti-hyperlipidemic activity for which the QSAR studies predicted the compound to be the β3-AR agonist, but the mechanism of its action was not elucidated. In our present study, we have evaluated the β3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline and its beneficial effect in insulin resistance. In this study, we have proposed the novel pharmacophore model using reported molecules for antihyperlipidemic activity. The reported pharmacophore features were also compared with the newly developed pharmacophore model for the observed biological activity. Based on 3D pharmacophore modeling of known β3AR agonist, we screened 20 synthetic derivatives of Aegeline from the literature. From these, the top scoring compound 10C was used for further studies. The in-slico result was further validated in HEK293T cells co-trransfected with human β3-AR and CRE-Luciferase reporter plasmid for β3-AR activity.The most active compound was selected and β3-AR activity was further validated in white and brown adipocytes differentiated from human mesenchymal stem cells (hMSCs). Insulin resistance model developed in hMSC derived adipocytes was used to study the insulin sensitizing property. 8 week HFD fed C57BL6 mice was given 50 mg/Kg of the selected compound and metabolic phenotyping was done to evaluate its anti-diabetic effect. As predicted by in-silico 3D pharmacophore modeling, the compound 10C was found to be the most active and specific β3-AR agonist with EC 50 value of 447 nM. The compound 10C activated β3AR pathway, induced lipolysis, fatty acid oxidation and increased oxygen consumption rate (OCR) in human adipocytes. Compound 10C induced expression of brown adipocytes specific markers and reverted chronic insulin induced insulin resistance in white

  1. Antinociceptive activity of fruits extracts and "arrope" of Geoffroea decorticans (chañar).

    Science.gov (United States)

    Reynoso, M A; Vera, N; Aristimuño, M E; Daud, A; Sánchez Riera, A

    2013-01-09

    Geoffroea decorticans (chañar) fruits and their derivate product (arrope) have been traditionally used as food and a folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorders and to relieve dolorous process. In order to evaluate the pharmacology action of this plant, studies were performed of antinociceptive and antioxidant activities. The aqueous and ethanolic extracts and arrope of chañar were evaluated in various established pain models, including chemical nociception induced by subplantar formalin and intraperitoneal acetic acid and thermal nociception method, such as tail immersion test in rats. To examine the possible connection of the opioid receptor to the antinociceptive activity of extracts and arrope it was performed a combination test with naloxone, a non-selective opioid receptor antagonist. The aqueous extract and arrope (1000 mg/kg) caused an inhibition of the pain in formalin test in the first phase, similar to morphine and decrease in the second phase. In a combination test using naloxone, diminished analgesic activity of aqueous extract and arrope were observed, indicating that antinociceptive activity is connected with the opioid receptor. The aqueous extract and arrope, caused an inhibition of the writhing response induced by acetic acid. Central involvement in analgesic profile was confirmed by the tail immersion test, in which the aqueous extract and arrope showed a significant analgesic activity by increasing latency time. The aqueous extract showed higher antioxidant activity than the arrope, it may be due to the cooking process. This study has shown that the aqueous extract and arrope of Geoffroea decorticans (chañar) fruits, does possess significant antinociceptive effects. It is further concluded that aqueous extract with maximum inhibition of free radical is the most potent extract amount tested extracts. At the oral doses tested the aqueous extract and arrope were non-toxic. The present

  2. Software Verification and Validation Report for the 244-AR Vault Interim Stabilization Ventilation System

    International Nuclear Information System (INIS)

    YEH, T.

    2002-01-01

    This document reports on the analysis, testing and conclusions of the software verification and validation for the 244-AR Vault Interim Stabilization ventilation system. Automation control system will use the Allen-Bradley software tools for programming and programmable logic controller (PLC) configuration. The 244-AR Interim Stabilization Ventilation System will be used to control the release of radioactive particles to the environment in the containment tent, located inside the canyon of the 244-AR facility, and to assist the waste stabilization efforts. The HVAC equipment, ducts, instruments, PLC hardware, the ladder logic executable software (documented code), and message display terminal are considered part of the temporary ventilation system. The system consists of a supply air skid, temporary ductwork (to distribute airflow), and two skid-mounted, 500-cfm exhausters connected to the east filter building and the vessel vent system. The Interim Stabilization Ventilation System is a temporary, portable ventilation system consisting of supply side and exhaust side. Air is supplied to the containment tent from an air supply skid. This skid contains a constant speed fan, a pre-filter, an electric heating coil, a cooling coil, and a constant flow device (CFD). The CFD uses a passive component that allows a constant flow of air to pass through the device. Air is drawn out of the containment tent, cells, and tanks by two 500-cfm exhauster skids running in parallel. These skids are equipped with fans, filters, stack, stack monitoring instrumentation, and a PLC for control. The 500CFM exhaust skids were fabricated and tested previously for saltwell pumping activities. The objective of the temporary ventilation system is to maintain a higher pressure to the containment tent, relative to the canyon and cell areas, to prevent contaminants from reaching the containment tent

  3. (e, 2e) processes on Ne, Ar and Xe targets

    Energy Technology Data Exchange (ETDEWEB)

    Purohit, G; Patidar, Vinod; Sud, K K, E-mail: g_vpurohit@yahoo.co, E-mail: ghanshyam.purohit@spsu.ac.i [Department of Physics, School of Engineering, Sir Padampat Singhania University, Bhatewar, Udaipur-313 601 (India)

    2010-06-01

    Recently, there have been several attempts to explain the features of triple differential cross section (TDCS) for the (e, 2e) processes on inert targets Ne, Ar and Xe but there are still certain discrepancies in theoretical results and measurements, which require more theoretical efforts to understand the collision dynamics of these targets. We present in this paper the results of our modified distorted wave Born approximation (DWBA) calculation of TDCS for the ionization of Ne (2p), Ar (3p) and Xe (5p) targets. We modify the standard DWBA formalism by including the correlation-polarization potential (which is function of electron density) and compare our computed results with the available experimental and theoretical data. We observe that the polarization potential is able to improve the agreement with experimental results.

  4. Ryoji Ikeda, Data Artist - Prix Ars Electronica Collide@CERN

    CERN Multimedia

    CERN. Geneva; Koek, Ariane; Heuer, Rolf; Ikeda, Ryoji; Mr. Horst, Hoertner

    2014-01-01

    at the CERN Globe of Science and Innovation, CERN. You are very warmly invited to the opening presentation of Data Artist, Ryoji Ikeda’s residency at CERN. Ryoji Ikeda, one of the world’s leading electronic composers and visual artists, is the new Prix Ars Electronica Collide@CERN award winner. Ryoji Ikeda and his science inspiration partner, Theoretical Physicist, Dr. Tom Melia will talk about their work in arts and science. They are at the beginning of their creative journey together at CERN. A little about Ryoji Ikeda – the new Prix Ars Electronica Collide@CERN artist in residence. Ryoji Ikeda focuses on the essential characteristics of sound itself and that of visuals as light by means of both mathematical precision and mathematical aesthetics. Ikeda has gained a reputation as one of the few international artists working convincingly across both visual ...

  5. A new empirical potential energy function for Ar2

    Science.gov (United States)

    Myatt, Philip T.; Dham, Ashok K.; Chandrasekhar, Pragna; McCourt, Frederick R. W.; Le Roy, Robert J.

    2018-06-01

    A critical re-analysis of all available spectroscopic and virial coefficient data for Ar2 has been used to determine an improved empirical analytic potential energy function that has been 'tuned' to optimise its agreement with viscosity, diffusion and thermal diffusion data, and whose short-range behaviour is in reasonably good agreement with the most recent ab initio calculations for this system. The recommended Morse/long-range potential function is smooth and differentiable at all distances, and incorporates both the correct theoretically predicted long-range behaviour and the correct limiting short-range functional behaviour. The resulting value of the well depth is ? cm-1 and the associated equilibrium distance is re = 3.766 (±0.002) Å, while the 40Ar s-wave scattering length is -714 Å.

  6. An Alternate Light Curve Solution of AR Lacertae

    Directory of Open Access Journals (Sweden)

    Hong Suh Park

    1984-09-01

    Full Text Available Photoelectric UBV light curves of AR Lacertae made in one season during 1981-82 are presented. Although the shape of the light curves in the outside eclipses show a strong distortion, the scatter of observations as well as phase coverage are better than those previously available. Fourier coefficients are derived from the V-light curve and observed curve successfully rectified to the Russell model. Light curve solutions are computed and the geometrical and physical parameters of AR Lac are derived as as = 0.812, ag = 0.341, j = 86°3, Ls = 0.372, Lg = 0.628, k = 0.53, Xs = 0.85, Xg = 0.4.

  7. Formation of doubly charged argon ions, Ar2+, from long-lived highly excited argon ions, Arsup(+*), colliding with Ar and N2 gases

    International Nuclear Information System (INIS)

    Okuno, Kazuhiko

    1976-01-01

    Formation of Ar 2+ from long-lived highly excited Ar + * colliding with Ar and N 2 gases is studied by means of a tandem mass spectrometer. The tandem mass spectrometer used consists of two mass analyzers connected in series and a collision chamber located in between. The collision chamber is electrically floated and can be set at a desired potential, so that one can identify the fast ions (resulting from the primary ions) and the slow ions (secondary ions) in the mass spectra taken by the second mass analyzer. When the first mass analyzer is tuned to Ar + , peaks corresponding Ar 2+ appear in the second mass spectra. From the analysis of variation of mass positions and heights of these peaks with the change of the potential and pressure of the collision chamber, the Ar 2+ is concluded to result from the primary Ar + in collision with gas molecules and wall surface. From the threshold behavior of the product Ar 2+ with the electron energy in the ion source, three sets of long-lived highly excited Ar + * states (Rydberg states) are found to be responsible for this process. They are 3s 2 3p 4 ( 3 P)nl, 3s 2 3p 4 ( 1 D 2 )n'l and 3s 2 3p 4 ( 1 S 0 )n''l converging to Ar 2+3 Psub(2.1.0) (43.38, 43.51, 43.57 eV), 1 D 2 (45.11 eV) and 1 S 0 (47.50 eV), respectively. Their fractional ratio in the primary Ar + beam is determined as 3.0:1.0:1.2 which is close to that of multiplicities of the states concerned. The autoionization mechanism reported by other investigators to be responsible for the formation of Ar 2+ in Aston band or tandem mass spectra is found to be negligible. The cross sections of formation of Ar 2+ from Ar + * colliding with Ar and N 2 increase in proportion to the 1.15th power of the collision energy in the range from 750 eV to 2.5 keV. At the collision energy of 1.0 keV, they are 2.0x10 -20 /F cm 2 for Ar target and 6.6x10 -20 /F cm 2 for N 2 target, where the fractional density of Ar + * is estimated to be 0.7x10 -4 -4 . (auth.)

  8. Selective AR Modulators that Distinguish Proliferative from Differentiative Gene Promoters

    Science.gov (United States)

    2017-08-01

    Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author(s) and should not be...Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT...recognition, we performed a high -throughput screen for compounds eliciting differential AR activity on cARE vs. sARE reporters. Of 10,000 compounds

  9. Augmented reality (AR) and virtual reality (VR) applied in dentistry

    OpenAIRE

    Ta-Ko Huang; Chi-Hsun Yang; Yu-Hsin Hsieh; Jen-Chyan Wang; Chun-Cheng Hung

    2018-01-01

    The OSCE is a reliable evaluation method to estimate the preclinical examination of dental students. The most ideal assessment for OSCE is used the augmented reality simulator to evaluate. This literature review investigated a recently developed in virtual reality (VR) and augmented reality (AR) starting of the dental history to the progress of the dental skill. As result of the lacking of technology, it needs to depend on other device increasing the success rate and decreasing the risk of th...

  10. Constructing carbon nanotube junctions by Ar ion beam irradiation

    International Nuclear Information System (INIS)

    Ishaq, Ahmad; Ni Zhichun; Yan Long; Gong Jinlong; Zhu Dezhang

    2010-01-01

    Carbon nanotubes (CNTs) irradiated by Ar ion beams at elevated temperature were studied. The irradiation-induced defects in CNTs are greatly reduced by elevated temperature. Moreover, the two types of CNT junctions, the crossing junction and the parallel junction, were formed. And the CNT networks may be fabricated by the two types of CNT junctions. The formation process and the corresponding mechanism of CNT networks are discussed.

  11. Children Road Safety Training with Augmented Reality (AR) [Demo

    OpenAIRE

    Lugmayr, Artur; Tsang, Joyce; Williams, Toby; Lim, Casey X; Teo, Yeet Yung; Farmer, Matthew

    2018-01-01

    Children killed or seriously injured through road accidents can be avoided through an appropriate safety training. Through play and engagement children learn and understand hazards at i.e. railway stations, bus stops, crossings, school zones, train stations, footpaths, or while cycling. We developed a rapid prototype of an Augmented Reality (AR) safety training proof-of-concept demonstrator for a scaled real-world model of dangerous road hazards. Two scenarios have been picked to give childre...

  12. He-, Ne-, and Ar-phosgene intermolecular potential energy surfaces

    DEFF Research Database (Denmark)

    Munteanu, Cristian R.; Henriksen, Christian; Felker, Peter M.

    2013-01-01

    Using the CCSD(T) model, we evaluated the intermolecular potential energy surfaces of the He-, Ne-, and Ar-phosgene complexes. We considered a representative number of intermolecular geometries for which we calculated the corresponding interaction energies with the augmented (He complex) and doub...... of the complexes, providing valuable results for future experimental investigations. Comparing our results to those previously available for other phosgene complexes, we suggest that the results for Cl2-phosgene should be revised....

  13. BUSINESS ETHICS: THE CASE OF AR CONSULTORIA LTD A

    Directory of Open Access Journals (Sweden)

    Fernando Fantoni Bencke

    2014-03-01

    business: the significant taxes, lack of incentives and credit available and the opportunity to “make a little extra” through informal sales. AR Consultoria’s entry to the market was marked by these and other difficulties. This case aims at presenting a real situation that can be found in some organizational sectors areas, which demands readers to take a decision and an ethical stance when faced with moral challenges.

  14. 40Ar/39Ar dating and zircon chronochemistry for the Izu-Bonin rear arc, IODP site U1437

    Science.gov (United States)

    Schmitt, A. K.; Konrad, K.; Andrews, G. D.; Horie, K.; Brown, S. R.; Koppers, A. A. P.; Busby, C.; Tamura, Y.

    2016-12-01

    The scientific objective of IODP Expedition 350 drilling at Site U1437 (31°47.390'N, 139°01.580'E) was to reveal the "missing half of the subduction factory": the rear arc of a long-lived intraoceanic subduction zone. Site U1437 lies in a 50 km long and 20 km wide volcano-bounded basin, 90 km west of the Izu arc front, and is the only IODP site drilled in the rear arc. The Izu rear arc is dominated by Miocene basaltic to dacitic seamount chains, which strike at a high angle to the arc front. Radiometric dating targeted a single igneous unit (1390 mbsf), and fine to coarse volcaniclastic units for which we present zircon and 40Ar/39Ar (hornblende, plagioclase, and groundmass) age determinations. All zircons analyzed as grain separates were screened for contamination from drill-mud (Andrews et al., 2016) by analyzing trace elements and, where material was available, O and Hf isotope compositions. Igneous Unit 1 is a rhyolite sheet and yielded concordant in-situ and crystal separate U-Pb zircon ages (13.7±0.3 Ma; MSWD = 1.3; n = 40 spots), whereas the 40Ar/39Ar hornblende plateau age (12.9±0.3; MSWD = 1.1; n = 9 steps) is slightly younger, possibly reflecting pre-eruptive zircon crystallization, or alteration of hornblende. U-Pb zircon and 40Ar/39Ar plateau ages from samples above igneous Unit 1 are concordant with biostratigraphic and paleomagnetic ages (available to 1300 mbsf), but plagioclase and groundmass samples below 1300 m become younger with depth, hinting at post-depositional alteration. A single zircon from 1600 mbsf yielded a U-Pb age of 15.4±1.8 Ma; its trace element composition resembles other igneous zircons from U1437, and is tentatively interpreted as a Middle Miocene age for the lowermost lithostratigraphic unit VII. Oxygen and Hf isotopic values of igneous zircon indicate mantle origins, with some influence of assimilation of hydrothermally altered oceanic crust evident in sub-mantle oxygen isotopic compositions. Lessons from site U1437 are

  15. 40Ar-39Ar age clustering in the active phonolitic Cadamosto Seamount (Cape Verdes): Indications for periodic magmatic activity

    Science.gov (United States)

    Samrock, L. K.; Hansteen, T. H.; Wartho, J. A.

    2017-12-01

    The Cape Verde archipelago is situated 400-800 km off the west coast of Africa and is comprised of a northern and southern chain of islands and seamounts. Morphological observations and previous radiometric dating of the islands indicate a slow age progression, over 22 Ma, from east to west (Holm et al. 2008). We present the first radiometric ages for Cadamosto Seamount, which is composed of complex evolved volcanics and is situated at the southwestern tip of the Cape Verde archipelago (e.g. Barker et al. 2012). We analyzed five different submarine phonolites that were sampled by remotely operated vehicles (ROV) Kiel 6000 and dredging during the RV Meteor (M80/3) and RV Poseidon (POS320/2) cruises. Fresh sanidine, nepheline, and biotite grains were selected and carefully prepared for 40Ar-39Ar single grain total fusion analysis. Sanidine single grain 40Ar-39Ar ages from 5 samples range from 11.5 ± 6.5 ka to 349.0 ± 20.4 ka (2σ errors), and cluster in several age groupings (using the decay constant and atmospheric air ratio of Steiger & Jäger (1977), and age standard TCS2 (27.87 ± 0.04 Ma; 1σ; M.A. Lanphere, pers. comm.)). Three age groups can be identified within the youngest (0-170 ka) sanidines, which are separated by periods of 52-54 ka. Nepheline grains from one sample yielded much older ages of 169.5 ± 16.5 ka to 1521.5 ± 8.3 ka (2σ). Our data suggests young ages for the Cadamosto Seamount, which is in accordance with recorded seismic activity (Grevemeyer et al. 2010), and its position adjacent to the recently active islands of Fogo (last eruption in 2014/2015) and Brava (recent seismic activity). The different sub-groups of sanidine 40Ar-39Ar ages can be used to identify different activity maxima corresponding to cycles of magmatic productivity in a long-lived magmatic system. Ongoing petrologic investigations will be used to identify the relative importance of processes such as mantle melting rates, magma replenishment and magma chamber processes

  16. Targeting AR Variant-Coactivator Interactions to Exploit Prostate Cancer Vulnerabilities.

    Science.gov (United States)

    Magani, Fiorella; Peacock, Stephanie O; Rice, Meghan A; Martinez, Maria J; Greene, Ann M; Magani, Pablo S; Lyles, Rolando; Weitz, Jonathan R; Burnstein, Kerry L

    2017-11-01

    Castration-resistant prostate cancer (CRPC) progresses rapidly and is incurable. Constitutively active androgen receptor splice variants (AR-Vs) represent a well-established mechanism of therapeutic resistance and disease progression. These variants lack the AR ligand-binding domain and, as such, are not inhibited by androgen deprivation therapy (ADT), which is the standard systemic approach for advanced prostate cancer. Signaling by AR-Vs, including the clinically relevant AR-V7, is augmented by Vav3, an established AR coactivator in CRPC. Using mutational and biochemical studies, we demonstrated that the Vav3 Diffuse B-cell lymphoma homology (DH) domain interacted with the N-terminal region of AR-V7 (and full length AR). Expression of the Vav3 DH domain disrupted Vav3 interaction with and enhancement of AR-V7 activity. The Vav3 DH domain also disrupted AR-V7 interaction with other AR coactivators: Src1 and Vav2, which are overexpressed in PC. This Vav3 domain was used in proof-of-concept studies to evaluate the effects of disrupting the interaction between AR-V7 and its coactivators on CRPC cells. This disruption decreased CRPC cell proliferation and anchorage-independent growth, caused increased apoptosis, decreased migration, and resulted in the acquisition of morphological changes associated with a less aggressive phenotype. While disrupting the interaction between FL-AR and its coactivators decreased N-C terminal interaction, disrupting the interaction of AR-V7 with its coactivators decreased AR-V7 nuclear levels. Implications: This study demonstrates the potential therapeutic utility of inhibiting constitutively active AR-V signaling by disrupting coactivator binding. Such an approach is significant, as AR-Vs are emerging as important drivers of CRPC that are particularly recalcitrant to current therapies. Mol Cancer Res; 15(11); 1469-80. ©2017 AACR . ©2017 American Association for Cancer Research.

  17. The Use of Tests in Admissions to Higher Education.

    Science.gov (United States)

    Fruen, Mary

    1978-01-01

    There are both strengths and weaknesses of using standardized test scores as a criterion for admission to institutions of higher education. The relative importance of scores is dependent on the institution's degree of selectivity. In general, decision processes and admissions criteria are not well defined. Advantages of test scores include: use of…

  18. Gender Gaps in High School GPA and ACT Scores: High School Grade Point Average and ACT Test Score by Subject and Gender. Information Brief 2014-12

    Science.gov (United States)

    ACT, Inc., 2014

    2014-01-01

    Female students who graduated from high school in 2013 averaged higher grades than their male counterparts in all subjects, but male graduates earned higher scores on the math and science sections of the ACT. This information brief looks at high school grade point average and ACT test score by subject and gender

  19. Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness

    International Nuclear Information System (INIS)

    Chen, Ji; Zhao, Yong; Li, Xin; Sun, Peng; Wang, Muwen; Wang, Ridong; Jin, Xunbo

    2012-01-01

    As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign prostate hyperplasia (BPH) tissue, controversy exists regarding the clinical value of 11C-Choline PET/CT scan in primary prostate cancer. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Then we evaluated whether the tracer 11C-Choline uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, and expression levels of several biomarkers of aggressiveness. Twenty-six patients with primary prostate cancer underwent 11C-Choline PET/CT. Tumour specimens from these patients were graded histopathologically, and immunnohistochemistry for Ki-67, CD31, androgen receptor (AR), Her-2/neu, Bcl-2, and PTEN were performed. Both SUVmax and SUVmax-P/M ratio showed no significant difference between patients with tumour stage II and III, but significantly elevated in patients with tumour stage IV. SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4. SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31. In addition, a higher SUVmax-P/M ratio was demonstrated in Her-2/neu positive subgroup than negative subgroup. At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax. Using the parameter SUVmax-P/M ratio, 11C-Choline PET/CT may be a valuable non-invasive imaging technology in the diagnosis of primary prostate cancer

  20. Pain Scores Are Not Predictive of Pain Medication Utilization

    Directory of Open Access Journals (Sweden)

    Suzanne Galloway

    2011-01-01

    Full Text Available Objective. To compare Visual Analogue Scale (VAS scores with overall postoperative pain medication requirements including cumulative dose and patterns of medication utilization and to determine whether VAS scores predict pain medication utilization. Methods. VAS scores and pain medication data were collected from participants in a randomized trial of the utility of phenazopyridine for improved pain control following gynecologic surgery. Results. The mean age of the 219 participants was 54 (range19 to 94. We did not detect any association between VAS and pain medication utilization for patient-controlled anesthesia (PCA or RN administered (intravenous or oral medications. We also did not detect any association between the number of VAS scores recorded and mean pain scores. Conclusion. Postoperative VAS scores do not predict pain medication use in catheterized women inpatients following gynecologic surgery. Increased pain severity, as reflected by higher VAS scores, is not associated with an increase in pain assessment. Our findings suggest that VAS scores are of limited utility for optimal pain control. Alternative or complimentary methods may improve pain management.