A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device

Directory of Open Access Journals (Sweden)

Chen Zhang

2013-01-01

Full Text Available Existing chemotaxis assays do not generate stable chemotactic gradients and thus—over time—functionally measure only nonspecific random motion (chemokinesis. In comparison, microfluidic technology has the capacity to generate a tightly controlled microenvironment that can be stably maintained for extended periods of time and is, therefore, amenable to adaptation for assaying chemotaxis. We describe here a novel microfluidic device for sensitive assay of cellular migration and show its application for evaluating the chemotaxis of smooth muscle cells in a chemokine gradient.

A high-resolution mK-calorimeter applying SQUID-thermometry

Energy Technology Data Exchange (ETDEWEB)

Reifenberger, Andreas; Leps, Norman; Fleischmann, Andreas; Pies, Christian; Enss, Christian; Klingeler, Ruediger [Kirchhoff-Institut fuer Physik, Universitaet Heidelberg, INF 227,69120 Heidelberg (Germany)

2012-07-01

A new calorimeter for measuring single-crystalline samples of mg-size at ultra-low temperatures is described. Thermometry is done by means of a paramagnetic sensor material (Er-doped Au) in a low magnetic field. A temperature change results in a magnetization change which can be read out as change in magnetic flux by a superconducting quantum interference device (SQUID). This enables measurements in a wide temperature range (theoretically from 1 mK-1 K) with very high sensitivities. The bolometric design exhibits low addenda heat capacity and allows measurements of heat capacities from nJ/K to {mu}J/K by means of a temperature-relaxation method. The performance of the device is compared to a commercially available Quantum Design calorimeter in elsewise unchanged experimental settings in the temperature range from 15 mK to 500 mK.

High luminosity liquid-argon calorimeter test beam

Energy Technology Data Exchange (ETDEWEB)

Novgorodova, Olga; Straessner, Arno [TU Dresden, IKTP (Germany)

2016-07-01

In the future HL-LHC the luminosity will increase by factor of 5-7 with respect to the original LHC design. The HiLum collaboration studied the impact on small-sized modules of the ATLAS electromagnetic, hadronic, and forward calorimeters also instrumented by various intensity and position detectors. The intensity of beam varied over a wide range (10{sup 6} to 10{sup 12} p/s) and beyond the maximum expected at HL-LHC for these calorimeters. Results from the last test beam campaign in 2013 on the signal shape analysis from the calorimeter modules are compared with MC simulations. The correlation between high-voltage return currents of the electromagnetic calorimeter and beam intensity is used to estimate critical parameters and compared with predictions.

Automated microfluidically controlled electrochemical biosensor for the rapid and highly sensitive detection of Francisella tularensis.

Science.gov (United States)

Dulay, Samuel B; Gransee, Rainer; Julich, Sandra; Tomaso, Herbert; O'Sullivan, Ciara K

2014-09-15

Tularemia is a highly infectious zoonotic disease caused by a Gram-negative coccoid rod bacterium, Francisella tularensis. Tularemia is considered as a life-threatening potential biological warfare agent due to its high virulence, transmission, mortality and simplicity of cultivation. In the work reported here, different electrochemical immunosensor formats for the detection of whole F. tularensis bacteria were developed and their performance compared. An anti-Francisella antibody (FB11) was used for the detection that recognises the lipopolysaccharide found in the outer membrane of the bacteria. In the first approach, gold-supported self-assembled monolayers of a carboxyl terminated bipodal alkanethiol were used to covalently cross-link with the FB11 antibody. In an alternative second approach F(ab) fragments of the FB11 antibody were generated and directly chemisorbed onto the gold electrode surface. The second approach resulted in an increased capture efficiency and higher sensitivity. Detection limits of 4.5 ng/mL for the lipopolysaccharide antigen and 31 bacteria/mL for the F. tularensis bacteria were achieved. Having demonstrated the functionality of the immunosensor, an electrode array was functionalised with the antibody fragment and integrated with microfluidics and housed in a tester set-up that facilitated complete automation of the assay. The only end-user intervention is sample addition, requiring less than one-minute hands-on time. The use of the automated microfluidic set-up not only required much lower reagent volumes but also the required incubation time was considerably reduced and a notable increase of 3-fold in assay sensitivity was achieved with a total assay time from sample addition to read-out of less than 20 min. Copyright © 2014 Elsevier B.V. All rights reserved.

pH-Sensitive Hydrogel for Micro-Fluidic Valve

Directory of Open Access Journals (Sweden)

Zhengzhi Yang

2012-07-01

Full Text Available The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydrogel constitutive equation, which is coded in commercial software, ABAQUS, to simulate the hydrogel valve swelling deformation, while FLUENT is adopted to model the fluid flow in the pipe of the hydrogel valve system. The study demonstrates that FSI significantly affects the gel swelling deformed shapes, fluid flow pressure and velocity patterns. FSI has to be considered in the study on fluid flow regulated by hydrogel microfluidic valve. The study provides a more accurate and adoptable model for future design of new pH-sensitive hydrogel valves, and also gives a useful guideline for further studies on hydrogel fluidic applications.

Theory and Development of Position-Sensitive Quantum Calorimeters. Degree awarded by Stanford Univ.

Science.gov (United States)

Figueroa-Feliciano, Enectali; White, Nicholas E. (Technical Monitor)

2001-01-01

Quantum calorimeters are being developed as imaging spectrometers for future X-ray astrophysics observatories. Much of the science to be done by these instruments could benefit greatly from larger focal-plane coverage of the detector (without increasing pixel size). An order of magnitude more area will greatly increase the science throughput of these future instruments. One of the main deterrents to achieving this goal is the complexity of the readout schemes involved. We have devised a way to increase the number of pixels from the current baseline designs by an order of magnitude without increasing the number of channels required for readout. The instrument is a high energy resolution, distributed-readout imaging spectrometer called a Position-Sensitive Transition-Edge Sensor (POST). A POST is a quantum calorimeter consisting of two Transition-Edge Sensors (TESS) on the ends of a long absorber capable of one-dimensional imaging spectroscopy. Comparing rise time and energy information from the two TESS, the position of the event in the POST is determined. The energy of the event is inferred from the sum of the two pulses. We have developed a generalized theoretical formalism for distributed-readout calorimeters and apply it to our devices. We derive the noise theory and calculate the theoretical energy resolution of a POST. Our calculations show that a 7-pixel POST with 6 keV saturation energy can achieve 2.3 eV resolution, making this a competitive design for future quantum calorimeter instruments. For this thesis we fabricated 7- and 15-pixel POSTS using Mo/Au TESs and gold absorbers, and moved from concept drawings on scraps of napkins to a 32 eV energy resolution at 1.5 keV, 7-pixel POST calorimeter.

Timing information and pileup rejection for the High Granularity Calorimeter

CERN Document Server

MONET, Geoffrey

2015-01-01

The Large Hadron Collider (LHC) at CERN is the world’s largest and most energetic hadron collider. The first run of the LHC (March 2010 - December 2012) has led to several measurements and discoveries, amongst which the Higgs boson candidate. In order to further increase its discovery potential beyond 2020 a leap in luminosity, by a factor of 10, is needed. It is what we call High Luminosity LHC (HL-LHC). Increase the total number of collision would provide more accurate measurements of new particles and enable observation of rare processes that occur below the current sensitivity level. The increase in luminosity will be achieved at the cost of an increase in pileup, i.e. the number of simultaneous collisions. Not only the LHC machine will be upgraded but also the detectors, namely CMS . To cope with this high pileup environment and reconstruct physics objects such as electrons, photons, jets and taus, High Granularity Calorimeter is being proposed as a substitute of the current endcap calorimeters of CMS...

Validation of GEANT4 Monte Carlo Models with a Highly Granular Scintillator-Steel Hadron Calorimeter

CERN Document Server

Adloff, C.; Blaising, J.J.; Drancourt, C.; Espargiliere, A.; Gaglione, R.; Geffroy, N.; Karyotakis, Y.; Prast, J.; Vouters, G.; Francis, K.; Repond, J.; Schlereth, J.; Smith, J.; Xia, L.; Baldolemar, E.; Li, J.; Park, S.T.; Sosebee, M.; White, A.P.; Yu, J.; Buanes, T.; Eigen, G.; Mikami, Y.; Watson, N.K.; Mavromanolakis, G.; Thomson, M.A.; Ward, D.R.; Yan, W.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Apostolakis, J.; Dotti, A.; Folger, G.; Ivantchenko, V.; Uzhinskiy, V.; Benyamna, M.; Cârloganu, C.; Fehr, F.; Gay, P.; Manen, S.; Royer, L.; Blazey, G.C.; Dyshkant, A.; Lima, J.G.R.; Zutshi, V.; Hostachy, J.Y.; Morin, L.; Cornett, U.; David, D.; Falley, G.; Gadow, K.; Gottlicher, P.; Gunter, C.; Hermberg, B.; Karstensen, S.; Krivan, F.; Lucaci-Timoce, A.I.; Lu, S.; Lutz, B.; Morozov, S.; Morgunov, V.; Reinecke, M.; Sefkow, F.; Smirnov, P.; Terwort, M.; Vargas-Trevino, A.; Feege, N.; Garutti, E.; Marchesini, I.; Ramilli, M.; Eckert, P.; Harion, T.; Kaplan, A.; Schultz-Coulon, H.Ch.; Shen, W.; Stamen, R.; Bilki, B.; Norbeck, E.; Onel, Y.; Wilson, G.W.; Kawagoe, K.; Dauncey, P.D.; Magnan, A.M.; Bartsch, V.; Wing, M.; Salvatore, F.; Alamillo, E.Calvo; Fouz, M.C.; Puerta-Pelayo, J.; Bobchenko, B.; Chadeeva, M.; Danilov, M.; Epifantsev, A.; Markin, O.; Mizuk, R.; Novikov, E.; Popov, V.; Rusinov, V.; Tarkovsky, E.; Kirikova, N.; Kozlov, V.; Smirnov, P.; Soloviev, Y.; Buzhan, P.; Ilyin, A.; Kantserov, V.; Kaplin, V.; Karakash, A.; Popova, E.; Tikhomirov, V.; Kiesling, C.; Seidel, K.; Simon, F.; Soldner, C.; Szalay, M.; Tesar, M.; Weuste, L.; Amjad, M.S.; Bonis, J.; Callier, S.; Conforti di Lorenzo, S.; Cornebise, P.; Doublet, Ph.; Dulucq, F.; Fleury, J.; Frisson, T.; van der Kolk, N.; Li, H.; Martin-Chassard, G.; Richard, F.; de la Taille, Ch.; Poschl, R.; Raux, L.; Rouene, J.; Seguin-Moreau, N.; Anduze, M.; Boudry, V.; Brient, J-C.; Jeans, D.; Mora de Freitas, P.; Musat, G.; Reinhard, M.; Ruan, M.; Videau, H.; Bulanek, B.; Zacek, J.; Cvach, J.; Gallus, P.; Havranek, M.; Janata, M.; Kvasnicka, J.; Lednicky, D.; Marcisovsky, M.; Polak, I.; Popule, J.; Tomasek, L.; Tomasek, M.; Ruzicka, P.; Sicho, P.; Smolik, J.; Vrba, V.; Zalesak, J.; Belhorma, B.; Ghazlane, H.; Takeshita, T.; Uozumi, S.; Gotze, M.; Hartbrich, O.; Sauer, J.; Weber, S.; Zeitnitz, C.

2013-01-01

Calorimeters with a high granularity are a fundamental requirement of the Particle Flow paradigm. This paper focuses on the prototype of a hadron calorimeter with analog readout, consisting of thirty-eight scintillator layers alternating with steel absorber planes. The scintillator plates are finely segmented into tiles individually read out via Silicon Photomultipliers. The presented results are based on data collected with pion beams in the energy range from 8GeV to 100GeV. The fine segmentation of the sensitive layers and the high sampling frequency allow for an excellent reconstruction of the spatial development of hadronic showers. A comparison between data and Monte Carlo simulations is presented, concerning both the longitudinal and lateral development of hadronic showers and the global response of the calorimeter. The performance of several GEANT4 physics lists with respect to these observables is evaluated.

Research on calorimeter for high-power microwave measurements

Energy Technology Data Exchange (ETDEWEB)

Ye, Hu; Ning, Hui; Yang, Wensen; Tian, Yanmin; Xiong, Zhengfeng; Yang, Meng; Yan, Feng; Cui, Xinhong [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi’an, Shaanxi 710024 (China)

2015-12-15

Based on measurement of the volume increment of polar liquid that is a result of heating by absorbed microwave energy, two types of calorimeters with coaxial capacitive probes for measurement of high-power microwave energy are designed in this paper. The first is an “inline” calorimeter, which is placed as an absorbing load at the end of the output waveguide, and the second is an “offline” calorimeter that is placed 20 cm away from the radiation horn of the high-power microwave generator. Ethanol and high density polyethylene are used as the absorbing and housing materials, respectively. Results from both simulations and a “cold test” on a 9.3 GHz klystron show that the “inline” calorimeter has a measurement range of more than 100 J and an energy absorption coefficient of 93%, while the experimental results on a 9.3 GHz relativistic backward-wave oscillator show that the device’s power capacity is approximately 0.9 GW. The same experiments were also carried out for the “offline” calorimeter, and the results indicate that it can be used to eliminate the effects of the shock of the solenoid on the measurement curves and that the device has a higher power capacity of 2.5 GW. The results of the numerical simulations, the “cold tests,” and the experiments show good agreement.

Research on calorimeter for high-power microwave measurements.

Science.gov (United States)

Ye, Hu; Ning, Hui; Yang, Wensen; Tian, Yanmin; Xiong, Zhengfeng; Yang, Meng; Yan, Feng; Cui, Xinhong

2015-12-01

Based on measurement of the volume increment of polar liquid that is a result of heating by absorbed microwave energy, two types of calorimeters with coaxial capacitive probes for measurement of high-power microwave energy are designed in this paper. The first is an "inline" calorimeter, which is placed as an absorbing load at the end of the output waveguide, and the second is an "offline" calorimeter that is placed 20 cm away from the radiation horn of the high-power microwave generator. Ethanol and high density polyethylene are used as the absorbing and housing materials, respectively. Results from both simulations and a "cold test" on a 9.3 GHz klystron show that the "inline" calorimeter has a measurement range of more than 100 J and an energy absorption coefficient of 93%, while the experimental results on a 9.3 GHz relativistic backward-wave oscillator show that the device's power capacity is approximately 0.9 GW. The same experiments were also carried out for the "offline" calorimeter, and the results indicate that it can be used to eliminate the effects of the shock of the solenoid on the measurement curves and that the device has a higher power capacity of 2.5 GW. The results of the numerical simulations, the "cold tests," and the experiments show good agreement.

Fractal dimension analysis in a highly granular calorimeter

CERN Document Server

Ruan, M; Brient, J.C; Jeans, D; Videau, H

2015-01-01

The concept of “particle flow” has been developed to optimise the jet energy resolution by distinguishing the different jet components. A highly granular calorimeter designed for the particle flow algorithm provides an unprecedented level of detail for the reconstruction of calorimeter showers and enables new approaches to shower analysis. In this paper the measurement and use of the fractal dimension of showers is described. The fractal dimension is a characteristic number that measures the global compactness of the shower. It is highly dependent on the primary particle type and energy. Its application in identifying particles and estimating their energy is described in the context of a calorimeter designed for the International Linear Collider.

Hadron showers in a highly granular calorimeter

International Nuclear Information System (INIS)

Lutz, Benjamin

2010-11-01

A future electron-positron collider like the planned International Linear Collider (ILC) needs excellent detectors to exploit the full physics potential. Different detector concepts have been evaluated for the ILC and two concepts on the particle-flow approach were validated. To make particle-flow work, a new type of imaging calorimeters is necessary in combination with a high performance tracking system, to be able to track the single particles through the full detector system. These calorimeters require an unprecedented level of both longitudinal and lateral granularity. Several calorimeter technologies promise to reach the required readout segmentation and are currently studied. This thesis addresses one of these: The analogue hadron calorimeter technology. It combines work on the technological aspects of a highly granular calorimeter with the study of hadron shower physics. The analogue hadron calorimeter technology joins a classical scintillator-steel sandwich design with a modern photo-sensor technology, the silicon photomultiplier (SiPM). The SiPM is a millimetre sized, magnetic field insensitive, and low cost photo-sensor, that opens new possibilities in calorimeter design. This thesis outlines the working principle and characteristics of these devices. The requirements for an application specific integrated circuit (ASIC) to read the SiPM are discussed; the performance of a prototype chip for SiPM readout, the SPIROC, is quantified. Also the SiPM specific reconstruction of a multi-thousand channel prototype calorimeter, the CALICE AHCAL, is explained; the systematic uncertainty of the calibration method is derived. The AHCAL does not only offer a test of the calorimeter technology, it also allows to record hadron showers with an unprecedented level of details. Test-beam measurements have been performed with the AHCAL and provide a unique sample for the development of novel analysis techniques and the validation of hadron shower simulations. A method to

Hadron showers in a highly granular calorimeter

Energy Technology Data Exchange (ETDEWEB)

Lutz, Benjamin

2010-11-15

A future electron-positron collider like the planned International Linear Collider (ILC) needs excellent detectors to exploit the full physics potential. Different detector concepts have been evaluated for the ILC and two concepts on the particle-flow approach were validated. To make particle-flow work, a new type of imaging calorimeters is necessary in combination with a high performance tracking system, to be able to track the single particles through the full detector system. These calorimeters require an unprecedented level of both longitudinal and lateral granularity. Several calorimeter technologies promise to reach the required readout segmentation and are currently studied. This thesis addresses one of these: The analogue hadron calorimeter technology. It combines work on the technological aspects of a highly granular calorimeter with the study of hadron shower physics. The analogue hadron calorimeter technology joins a classical scintillator-steel sandwich design with a modern photo-sensor technology, the silicon photomultiplier (SiPM). The SiPM is a millimetre sized, magnetic field insensitive, and low cost photo-sensor, that opens new possibilities in calorimeter design. This thesis outlines the working principle and characteristics of these devices. The requirements for an application specific integrated circuit (ASIC) to read the SiPM are discussed; the performance of a prototype chip for SiPM readout, the SPIROC, is quantified. Also the SiPM specific reconstruction of a multi-thousand channel prototype calorimeter, the CALICE AHCAL, is explained; the systematic uncertainty of the calibration method is derived. The AHCAL does not only offer a test of the calorimeter technology, it also allows to record hadron showers with an unprecedented level of details. Test-beam measurements have been performed with the AHCAL and provide a unique sample for the development of novel analysis techniques and the validation of hadron shower simulations. A method to

Automated Microfluidic Platform for Serial Polymerase Chain Reaction and High-Resolution Melting Analysis.

Science.gov (United States)

Cao, Weidong; Bean, Brian; Corey, Scott; Coursey, Johnathan S; Hasson, Kenton C; Inoue, Hiroshi; Isano, Taisuke; Kanderian, Sami; Lane, Ben; Liang, Hongye; Murphy, Brian; Owen, Greg; Shinoda, Nobuhiko; Zeng, Shulin; Knight, Ivor T

2016-06-01

We report the development of an automated genetic analyzer for human sample testing based on microfluidic rapid polymerase chain reaction (PCR) with high-resolution melting analysis (HRMA). The integrated DNA microfluidic cartridge was used on a platform designed with a robotic pipettor system that works by sequentially picking up different test solutions from a 384-well plate, mixing them in the tips, and delivering mixed fluids to the DNA cartridge. A novel image feedback flow control system based on a Canon 5D Mark II digital camera was developed for controlling fluid movement through a complex microfluidic branching network without the use of valves. The same camera was used for measuring the high-resolution melt curve of DNA amplicons that were generated in the microfluidic chip. Owing to fast heating and cooling as well as sensitive temperature measurement in the microfluidic channels, the time frame for PCR and HRMA was dramatically reduced from hours to minutes. Preliminary testing results demonstrated that rapid serial PCR and HRMA are possible while still achieving high data quality that is suitable for human sample testing. © 2015 Society for Laboratory Automation and Screening.

The Dynamic Characteristic Analysis of Mini Gamma Calorimeter

International Nuclear Information System (INIS)

Setiyanto

2004-01-01

The gamma calorimeter is a facility to measure the gamma heating in the nuclear reactor. The dimensions of the conventional calorimeters are in general too large, that is an inconvenience if those calorimeters will be applied in the high temperature reactor as a nuclear power plant. To avoid that inconvenience, it is necessary to propose the innovation on the feature of the existing calorimeter. The basic idea of the innovation is to create the small type of calorimeter without the absorbed material. The last analysis was realized to determine of the static calorimeter characteristic or sensitivities as a function of the dimension and the material of gas isolations. Based on those results, the analyses is reasonably to be continued to determine the dynamic characteristic or period of calorimeter. The analysis was performed using the finite difference method, two dimension simplified. It can be concluded that the mini gamma calorimeter proposed is reasonable to be made. (author)

Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers

Science.gov (United States)

Kurnia, Jundika C.; Birgersson, Erik; Mujumdar, Arun S.

2011-01-01

This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demonstrate how the model is implemented to study the sensing and actuating behavior of hydrogels for different microfluidic flow channel/hydrogel configurations: e.g., for flow in a T-junction with single and multiple hydrogels. In short, the results suggest that the response of the hydrogel-based flow controller is slow. Therefore, two strategies to improve the response rate of the hydrogels are proposed and demonstrated. Finally, we highlight that the model can be extended to include other stimuli-responsive hydrogels such as thermo-, electric-, and glucose-sensitive hydrogels. PMID:24956303

Sensors for the CMS High Granularity Calorimeter

CERN Document Server

Maier, Andreas Alexander

2017-01-01

The CMS experiment is currently developing high granularity calorimeter endcapsfor its HL-LHC upgrade. The design foresees silicon sensors as the active material for the high radiation region close to the beampipe. Regions of lower radiation are additionally equipped with plastic scintillator tiles. This technology is similar to the calorimeter prototypes developed in the framework of the Linear Collider by the CALICE collaboration. The current status of the silicon sensor development is presented. Results of single diode measurements are shown as well as tests of full 6-inch hexagonal sensor wafers. A short summary of test beam results concludes the article.

Automatic low-temperature calorimeter

International Nuclear Information System (INIS)

Malyshev, V.M.; Mil'ner, G.A.; Shibakin, V.F.; Sorkin, E.L.

1986-01-01

This paper describes a low-temperature adiabatic calorimeter with a range of 1.5-500K. The system for maintaining adiabatic conditions is implemented by two resitance thermometers, whose sensitivity at low temperatures is several orders higher than that of thermocouples. The calorimeter cryostat is installed in an STG-40 portable Dewar flask. The calorimeter is controlled by an Elektronika-60 microcomputer. Standard platinum and germanium thermometers were placed inside of the calorimeter to calibrate the thermometers of the calorimeter and the shield, and the specific heats of specimens of OSCh 11-4 copper and KTP-8 paste were measured to demonstrate the possibilities of the described calorimeter. Experience with the calorimeter has shown that a thorough study of the dependence of heat capacity on temperature (over 100 points for one specimen) can be performed in one or two dats

High content screening in microfluidic devices

Science.gov (United States)

Cheong, Raymond; Paliwal, Saurabh; Levchenko, Andre

2011-01-01

Importance of the field Miniaturization is key to advancing the state-of-the-art in high content screening (HCS), in order to enable dramatic cost savings through reduced usage of expensive biochemical reagents and to enable large-scale screening on primary cells. Microfluidic technology offers the potential to enable HCS to be performed with an unprecedented degree of miniaturization. Areas covered in this review This perspective highlights a real-world example from the authors’ work of HCS assays implemented in a highly miniaturized microfluidic format. Advantages of this technology are discussed, including cost savings, high throughput screening on primary cells, improved accuracy, the ability to study complex time-varying stimuli, and ease of automation, integration, and scaling. What the reader will gain The reader will understand the capabilities of a new microfluidics-based platform for HCS, and the advantages it provides over conventional plate-based HCS. Take home message Microfluidics technology will drive significant advancements and broader usage and applicability of HCS in drug discovery. PMID:21852997

The ATLAS High-Level Calorimeter Trigger in Run-2

CERN Document Server

Wiglesworth, Craig; The ATLAS collaboration

2018-01-01

The ATLAS Experiment uses a two-level triggering system to identify and record collision events containing a wide variety of physics signatures. It reduces the event rate from the bunch-crossing rate of 40 MHz to an average recording rate of 1 kHz, whilst maintaining high efficiency for interesting collision events. It is composed of an initial hardware-based level-1 trigger followed by a software-based high-level trigger. A central component of the high-level trigger is the calorimeter trigger. This is responsible for processing data from the electromagnetic and hadronic calorimeters in order to identify electrons, photons, taus, jets and missing transverse energy. In this talk I will present the performance of the high-level calorimeter trigger in Run-2, noting the improvements that have been made in response to the challenges of operating at high luminosity.

Microfabrication and Applications of Opto-Microfluidic Sensors

Science.gov (United States)

Zhang, Daiying; Men, Liqiu; Chen, Qiying

2011-01-01

A review of research activities on opto-microfluidic sensors carried out by the research groups in Canada is presented. After a brief introduction of this exciting research field, detailed discussion is focused on different techniques for the fabrication of opto-microfluidic sensors, and various applications of these devices for bioanalysis, chemical detection, and optical measurement. Our current research on femtosecond laser microfabrication of optofluidic devices is introduced and some experimental results are elaborated. The research on opto-microfluidics provides highly sensitive opto-microfluidic sensors for practical applications with significant advantages of portability, efficiency, sensitivity, versatility, and low cost. PMID:22163904

Fractal Dimension of Particle Showers Measured in a Highly Granular Calorimeter

CERN Document Server

Ruan, Manqi; Bourdy, Vincent; Brients, Jean-Claude; Videau, Henri

2014-01-01

fractal dimension of showers measured in a high granularity calorimeter designed for a future lepton collider. The shower fractal dimension reveals detailed information of the spatial configuration of the shower. It is found to be characteristic of the type of interaction and highly sensitive to the nature of the incident particle. Using the shower fractal dimension, we demonstrate a particle identification algorithm that can efficiently separate electromagnetic showers, hadronic showers and non-showering tracks. We also find a logarithmic dependence of the shower fractal dimension on the particle energy.

Optical calorimetry in microfluidic droplets.

Science.gov (United States)

Chamoun, Jacob; Pattekar, Ashish; Afshinmanesh, Farzaneh; Martini, Joerg; Recht, Michael I

2018-05-29

A novel microfluidic calorimeter that measures the enthalpy change of reactions occurring in 100 μm diameter aqueous droplets in fluoropolymer oil has been developed. The aqueous reactants flow into a microfluidic droplet generation chip in separate fluidic channels, limiting contact between the streams until immediately before they form the droplet. The diffusion-driven mixing of reactants is predominantly restricted to within the droplet. The temperature change in droplets due to the heat of reaction is measured optically by recording the reflectance spectra of encapsulated thermochromic liquid crystals (TLC) that are added to one of the reactant streams. As the droplets travel through the channel, the spectral characteristics of the TLC represent the internal temperature, allowing optical measurement with a precision of ≈6 mK. The microfluidic chip and all fluids are temperature controlled, and the reaction heat within droplets raises their temperature until thermal diffusion dissipates the heat into the surrounding oil and chip walls. Position resolved optical temperature measurement of the droplets allows calculation of the heat of reaction by analyzing the droplet temperature profile over time. Channel dimensions, droplet generation rate, droplet size, reactant stream flows and oil flow rate are carefully balanced to provide rapid diffusional mixing of reactants compared to thermal diffusion, while avoiding thermal "quenching" due to contact between the droplets and the chip walls. Compared to conventional microcalorimetry, which has been used in this work to provide reference measurements, this new continuous flow droplet calorimeter has the potential to perform titrations ≈1000-fold faster while using ≈400-fold less reactants per titration.

High-Energy 3D Calorimeter based on position-sensitive virtual Frisch-grid CdZnTe detectors for use in Gamma-ray Astronomy

Energy Technology Data Exchange (ETDEWEB)

Bolotnikov, Alexey [Brookhaven National Lab. (BNL), Upton, NY (United States); De Geronimo, GianLuigi [Brookhaven National Lab. (BNL), Upton, NY (United States); Vernon, Emerson [Brookhaven National Lab. (BNL), Upton, NY (United States); Hays, Elizabeth [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States); Thompson, David [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States); James, Ralph [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Moiseev, Alexander [Center for Research and Exploration; Technology, NASA Goddard Space Flight Center (GSFC) and Univ. of Maryland, Greenbelt, MD (United States)

2017-08-12

We present a concept for a calorimeter based on a novel approach of 3D position-sensitive virtual Frischgrid CZT detectors. This calorimeter aims to measure photons with energies from ~100 keV to 10 (goal 50) MeV. The expected energy resolution at 662 keV is ~1% FWHM, and the photon interaction positionmeasurement accuracy is ~1 mm in all 3 dimensions. Each CZT bar is a rectangular prism with typical cross-section of 6x6 mm² and length of 2-4 cm. The bars are arranged in modules of 4 x 4 bars, and the modules themselves can be assembled into a larger array. The 3D virtual voxel approach solves a long-standing problem with CZT detectors associated with material imperfections that limit the performance and usefulness of relatively thick detectors (i.e., > 1 cm). Also, it allows us to relax the requirements on the quality of the crystals, maintaining good energy resolution and significantly reducing the instrument cost. Such a calorimeter can be successfully used in space telescopes that use Compton scattering of γ rays, such as AMEGO, serving as part of its calorimeter and providing the position and energy measurement for Compton-scattered photons. Also, it could provide suitable energy resolution to allow for spectroscopic measurements of γ-ray lines from nuclear decays. Another viable option is to use this calorimeter as a focal plane to conduct spectroscopic measurements of cosmic γ-ray events. In combination with a coded-aperture mask, it potentially could provide mapping of the 511-keV radiation from the Galactic Center region.

Upgrade of the ATLAS Tile Calorimeter for the High Luminosity LHC

CERN Document Server

Tang, Fukun; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter of ATLAS covering the central region of the ATLAS experiment. TileCal will undergo a major replacement of its on- and off-detector electronics in 2024 for the high luminosity program of the LHC. The calorimeter signals will be digitized and sent directly to the off-detector electronics, where the signals are reconstructed and transmitted to the first level of trigger at a rate of 40 MHz. This will provide a better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Three different options are presently being investigated for the front-end electronic upgrade. Extensive test beam studies are being employed to determine which option will be selected. The off-detector electronics are based on the Advanced Telecommunications Computing Architecture (ATCA) standard and are equipped with high performance optical connectors. The system is designed to operate in a high radiation envi...

Upgrade of the ATLAS Tile Calorimeter for the High Luminosity LHC

CERN Document Server

Tang, Fukun; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter of ATLAS cover-ing the central region of the ATLAS experiment. TileCal will undergo a major replacement of its on- and off-detector electronics in 2024 for the high luminosity program of the LHC. The calorimeter signals will be digitized and sent directly to the off-detector electronics, where the signals are reconstructed and shipped to the first level of trigger at a rate of 40 MHz. This will provide a better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Three different options are presently being investigated for the front-end electronic upgrade. Extensive test beam studies are being employed to determine which option will be selected. The off-detector electronic is based on the Advanced Telecommunications Computing Architecture (ATCA) standard and is equipped with high performance optical connectors. The system is designed to operate in a high radiation environmen...

The CMS High Granularity Calorimeter for the High Luminosity LHC

CERN Document Server

Sauvan, Jean-baptiste

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with silicon photomultiplier (SiPM) readout. The intrinsic high-precision timing capabilities...

A highly efficient microfluidic nano biochip based on nanostructured nickel oxide.

Science.gov (United States)

Ali, Md Azahar; Solanki, Pratima R; Patel, Manoj K; Dhayani, Hemant; Agrawal, Ved Varun; John, Renu; Malhotra, Bansi D

2013-04-07

We present results of the studies relating to fabrication of a microfluidic biosensor chip based on nickel oxide nanorods (NRs-NiO) that is capable of directly measuring the concentration of total cholesterol in human blood through electrochemical detection. Using this chip we demonstrate, with high reliability and in a time efficient manner, the detection of cholesterol present in buffer solutions at clinically relevant concentrations. The microfluidic channel has been fabricated onto a nickel oxide nanorod-based electrode co-immobilized with cholesterol esterase (ChEt) and cholesterol oxidase (ChOx) that serves as the working electrode. Bare indium tin oxide served as the counter electrode. A Ag/AgCl wire introduced to the outlet of the microchannel acts as a reference electrode. The fabricated NiO nanorod-based electrode has been characterized using X-ray diffraction, Raman spectroscopy, HR-TEM, FT-IR, UV-visible spectroscopy and electrochemical techniques. The presented NRs-NiO based microfluidic sensor exhibits linearity in the range of 1.5-10.3 mM, a high sensitivity of 0.12 mA mM(-1) cm(-2) and a low value of 0.16 mM of the Michaelis-Menten constant (Km).

Indirect measurement of the magnetocaloric effect using a novel differential scanning calorimeter with magnetic field

DEFF Research Database (Denmark)

Jeppesen, Stinus; Linderoth, Søren; Pryds, Nini

2008-01-01

A simple and high-sensitivity differential scanning calorimeter (DSC) unit operating under magnetic field has been built for indirect determination of the magnetocaloric effect. The principle of the measuring unit in the calorimeter is based on Peltier elements as heat flow sensors. The high...

Pion showers in highly granular calorimeters

Czech Academy of Sciences Publication Activity Database

Cvach, Jaroslav

2012-01-01

Roč. 79, č. 4 (2012), s. 859-862 ISSN 0304-4289. [International Symposium on Lepton-Photon Interactions at High Energies /25./. Mumbai, 22.08.2011-27.08.2011] R&D Projects: GA MŠk LA09042 Institutional research plan: CEZ:AV0Z10100502 Keywords : International Linear Collider * particle flow algorithm * calorimeter resolution Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 0.562, year: 2012

PANDA electromagnetic calorimeters

International Nuclear Information System (INIS)

Semenov, P.A.; Kharlov, Yu.V.; Uzunian, A.V.; Chernichenko, S.K.; Derevschikov, A.A.; Davidenko, A.M.; Goncharenko, Y.M.; Kachanov, V.A.; Konstantinov, A.S.; Kormilitsin, V.A.; Matulenko, Yu.A.; Meschanin, A.P.; Melnick, Y.M.; Minaev, N.G.; Mochalov, V.V.; Morozov, D.A.; Novotny, R.W.; Ryazantsev, A.A.; Soldatov, A.P.; Soloviev, L.F.

2009-01-01

PANDA is a challenging experimental setup to be implemented at the high-energy storage ring (HESR) at the international facility FAIR, GSI (Germany). PANDA physics program relies heavily on the capability to measure photons with excellent energy, position and timing resolution. For this purpose PANDA proposed to employ electromagnetic calorimeters using two different technologies: compact crystal calorimeter cooled to -25 deg. C around target and lead-scintillator sandwich calorimeter with optical fibers light collection (so-called shashlyk calorimeter) in the forward region. Institute for High Energy Physics (IHEP) PANDA group reports on two types of measurements performed at IHEP, Protvino: radiation hardness of the PWO crystals at -25 deg. C and testbeam studies of the energy and position resolution of the shashlyk calorimeter prototype in the energy range up to 19 GeV.

Pion showers in highly granular calorimeters

Indian Academy of Sciences (India)

New results on properties of hadron showers created by pion beam at 8–80 GeV in high granular electromagnetic and hadron calorimeters are presented. Data were used for the first time to investigate the separation of the neutral and charged hadron showers. The result is important to verify the prediction of the PFA ...

CALICE silicon-tungsten electromagnetic calorimeter

Indian Academy of Sciences (India)

A highly granular electromagnetic calorimeter prototype based on tungsten absorber and sampling units equipped with silicon pads as sensitive devices for signal collection is under construction. The full prototype will have in total 30 layers and be read out by about 10000 Si cells of 1 × 1 cm2. A first module consisting of 14 ...

Spectroscopic Investigations of Highly Charged Ions using X-Ray Calorimeter Spectrometers

Energy Technology Data Exchange (ETDEWEB)

Thorn, Daniel Bristol [Univ. of California, Davis, CA (United States)

2008-11-19

Spectroscopy of K-shell transitions in highly charged heavy ions, like hydrogen-like uranium, has the potential to yield information about quantum electrodynamics (QED) in extremely strong nuclear fields as well as tests of the standard model, specifically parity violation in atomic systems. These measurements would represent the 'holy grail' in high-Z atomic spectroscopy. However, the current state-of-the-art detection schemes used for recording the K-shell spectra from highly charged heavy ions does not yet have the resolving power to be able to attain this goal. As such, to push the field of high-Z spectroscopy forward, new detectors must be found. Recently, x-ray calorimeter spectrometers have been developed that promise to make such measurements. In an effort to make the first steps towards attaining the 'holy grail', measurements have been performed with two x-ray calorimeter spectrometers (the XRS/EBIT and the ECS) designed and built at Goddard Space Flight Center in Greenbelt, MD. The calorimeter spectrometers have been used to record the K-shell spectra of highly charged ions produced in the SuperEBIT electron beam ion trap at Lawrence Livermore National Laboratory in Livermore, CA. Measurements performed with the XRS/EBIT calorimeter array found that the theoretical description of well-above threshold electron-impact excitation cross sections for hydrogen-like iron and nickel ions are correct. Furthermore, the first high-resolution spectrum of hydrogen-like through carbon-like praseodymium ions was recorded with a calorimeter. In addition, the new high-energy array on the EBIT Calorimeter Spectrometer (ECS) was used to resolve the K-shell x-ray emission spectrum of highly charged xenon ions, where a 40 ppm measurement of the energy of the K-shell resonance transition in helium-like xenon was achieved. This is the highest precision result, ever, for an element with such high atomic number. In addition, a first-of-its-kind measurement of

Spectroscopic Investigations of Highly Charged Ions using X-Ray Calorimeter Spectrometers

International Nuclear Information System (INIS)

Thorn, D. B.

2008-01-01

Spectroscopy of K-shell transitions in highly charged heavy ions, like hydrogen-like uranium, has the potential to yield information about quantum electrodynamics (QED) in extremely strong nuclear fields as well as tests of the standard model, specifically parity violation in atomic systems. These measurements would represent the 'holy grail' in high-Z atomic spectroscopy. However, the current state-of-the-art detection schemes used for recording the K-shell spectra from highly charged heavy ions does not yet have the resolving power to be able to attain this goal. As such, to push the field of high-Z spectroscopy forward, new detectors must be found. Recently, x-ray calorimeter spectrometers have been developed that promise to make such measurements. In an effort to make the first steps towards attaining the 'holy grail', measurements have been performed with two x-ray calorimeter spectrometers (the XRS/EBIT and the ECS) designed and built at Goddard Space Flight Center in Greenbelt, MD. The calorimeter spectrometers have been used to record the K-shell spectra of highly charged ions produced in the SuperEBIT electron beam ion trap at Lawrence Livermore National Laboratory in Livermore, CA. Measurements performed with the XRS/EBIT calorimeter array found that the theoretical description of well-above threshold electron-impact excitation cross sections for hydrogen-like iron and nickel ions are correct. Furthermore, the first high-resolution spectrum of hydrogen-like through carbon-like praseodymium ions was recorded with a calorimeter. In addition, the new high-energy array on the EBIT Calorimeter Spectrometer (ECS) was used to resolve the K-shell x-ray emission spectrum of highly charged xenon ions, where a 40 ppm measurement of the energy of the K-shell resonance transition in helium-like xenon was achieved. This is the highest precision result, ever, for an element with such high atomic number. In addition, a first-of-its-kind measurement of the effect of the

Readout Electronics for the ATLAS LAr Calorimeter at HL-LHC

CERN Document Server

Chen, H; The ATLAS collaboration

2011-01-01

The ATLAS experiment is one of the two general-purpose detectors designed to study proton-proton collisions (14 TeV in the center of mass) produced at the Large Hadron Collider (LHC) and to explore the full physics potential of the LHC machine at CERN. The ATLAS Liquid Argon (LAr) calorimeters are high precision, high sensitivity and high granularity detectors designed to provide precision measurements of electrons, photons, jets and missing transverse energy. ATLAS (and its LAr Calorimeters) has been operating and collecting p-p collisions at LHC since 2009. The on-detector electronics (front-end) part of the current readout electronics of the calorimeters measures the ionization current signals by means of preamplifiers, shapers and digitizers and then transfers the data to the off-detector electronics (back-end) for further elaboration, via optical links. Only the data selected by the level-1 calorimeter trigger system are transferred, achieving a bandwidth reduction to 1.6 Gbps. The analog trigger sum sig...

Flow Type Bio-Chemical Calorimeter with Micro Differential Thermopile Sensor.

Science.gov (United States)

Saito, Masataka; Nakabeppu, Osamu

2015-04-01

Bio-chemical calorimeters with a MEMS (Micro-Electro-Mechanical Systems) thermopile sensor have been studied for monitoring detailed processes of the biochemical reactions of a minute sample with a high temporal resolution. The bio-calorimeters are generally divided into a batch-type and a flow-type. We developed a highly sensitive batch-type calorimeter which can detect a 100 nW level thermal reaction. However it shows a long settling time of 2 hours because of the heat capacity of a whole calorimeter. Thus, the flow-type calorimeters in passive and active mode have been studied for measuring the thermal reactions in an early stage after starting an analysis. The flow-type calorimeter consists of the MEMS differential thermopile sensor, a pair of micro channel reactor in a PDMS (polydimethylsiloxane) sheet in a three-fold thermostat chamber. The calorimeter in the passive mode was tested with dilution reactions of ethanol to water and NaCl aqueous solution to water. It was shown that the calorimeter detects exo- and endothermic reaction over 250 nW at solution flow rate of 0.05 ~ 1 µl/min with a settling time of about 4 minutes. In the active mode, a response test was conducted by using heat removal by water flow from the reactor channel. The active calorimetry enhances the response time about three to four times faster.

The CMS High Granularity Calorimeter for the High Luminosity LHC

Science.gov (United States)

Sauvan, J.-B.

2018-02-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5-1 cm2 cell size, with the remainder of the HCAL based on highly-segmented scintillators with silicon photomultiplier (SiPM) readout. The intrinsic high-precision timing capabilities of the silicon sensors will add an extra dimension to event reconstruction, especially in terms of pileup rejection.

Self-contained microfluidic systems: a review.

Science.gov (United States)

Boyd-Moss, Mitchell; Baratchi, Sara; Di Venere, Martina; Khoshmanesh, Khashayar

2016-08-16

Microfluidic systems enable rapid diagnosis, screening and monitoring of diseases and health conditions using small amounts of biological samples and reagents. Despite these remarkable features, conventional microfluidic systems rely on bulky expensive external equipment, which hinders their utility as powerful analysis tools outside of research laboratories. 'Self-contained' microfluidic systems, which contain all necessary components to facilitate a complete assay, have been developed to address this limitation. In this review, we provide an in-depth overview of self-contained microfluidic systems. We categorise these systems based on their operating mechanisms into three major groups: passive, hand-powered and active. Several examples are provided to discuss the structure, capabilities and shortcomings of each group. In particular, we discuss the self-contained microfluidic systems enabled by active mechanisms, due to their unique capability for running multi-step and highly controllable diagnostic assays. Integration of self-contained microfluidic systems with the image acquisition and processing capabilities of smartphones, especially those equipped with accessory optical components, enables highly sensitive and quantitative assays, which are discussed. Finally, the future trends and possible solutions to expand the versatility of self-contained, stand-alone microfluidic platforms are outlined.

Liquid Argon Calorimeter performance at High Rates

CERN Document Server

Seifert, F; The ATLAS collaboration

2013-01-01

The expected increase of luminosity at HL-LHC by a factor of ten with respect to LHC luminosities has serious consequences for the signal reconstruction, radiation hardness requirements and operations of the ATLAS liquid argon calorimeters in the endcap, respectively forward region. Small modules of each type of calorimeter have been built and exposed to a high intensity proton beam of 50 GeV at IHEP/Protvino. The beam is extracted via the bent crystal technique, offering the unique opportunity to cover intensities ranging from $10^6$ p/s up to $3\\cdot10^{11}$ p/s. This exceeds the deposited energy per time expected at HL-LHC by more than a factor of 100. The correlation between beam intensity and the read-out signal has been studied. The data show clear indications of pulse shape distortion due to the high ionization build-up, in agreement with MC expectations. This is also confirmed from the dependence of the HV currents on beam intensity.

Proportional wire calorimeters at ISABELLE

International Nuclear Information System (INIS)

Matthews, J.A.J.

1979-01-01

Gas calorimeters have recently increased in popularity because they provide a simple method of achieving a high degree of calorimeter segmentation with only a modest loss in energy resolution compared with liquid argon or scintillator calorimeters. High radiation levels at ISABELLE will result in gas calorimeter lifetimes similar to those of MWPCs, although the intermediate speed of these devices may cause some resolution degradation due to signal pileup. Schemes for calibration and monitoring gas calorimeters in situ must be evolved and will presumably utilize a combination of pulsers, imbedded 55 Fe sources, etc. Most of the recent development work on gas calorimeters has been centered on electromagnetic (em) calorimetry for large detectors at CESR and PEP. Data on the performance of gas calorimeters are given and compared with the liquid argon results of Hitlin et al. The hadronic gas calorimeter results of Anderson et al. are shown along with typical energy resolution results from various scintillator and liquid argon steel calorimeters

The CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Mastrolorenzo, Luca

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

Sampling calorimeters in high energy physics

International Nuclear Information System (INIS)

Gordon, H.A.; Smith, S.D.

1980-01-01

Attention is given to sampling calorimeters - those instruments in which part of the shower is sampled in an active medium sandwiched between absorbing layers. A very cursory overview is presented of some fundamental aspects of sampling calorimeters. First the properties of shower development are described for both the electromagnetic and hadronic cases. Then examples of various readout schemes are discussed. Finally, some currently promising new ideas in calorimetry are described

Development of a portable graphite calorimeter for photons and electrons

International Nuclear Information System (INIS)

McEwen, M.R.; Duane, S.

1999-01-01

The aim of this project is to develop a calorimeter for use in both electron and photon beams. The calorimeter should be more robust than the present NPL primary standard X-ray calorimeter and is designed to be sufficiently portable to enable measurements at clinical accelerators away from NPL. Although intended for therapy-level dosimetry, the new calorimeter can also be used for high-dose measurements at industrial facilities. The system consists of a front end (the calorimeter itself), means for thermal isolation and temperature control, and a measurement system based on thermistors in a DC Wheatstone bridge. The early part of the project focused on the development of a temperature control system sensitive enough to allow measurements of temperature rises of the order of 1 mK. The control system responds to the calorimeter, phantom and air temperatures and maintains the temperature of the calorimeter to within ± 0.2 mK over several hours. Initial operation at NPL in 6, 10 and 16 MV X-ray beams show that the system is capable of measurements of 1 Gy at 2 Gy/min with a random uncertainty of ± 0.5% (1 standard deviation). (author)

Twin solution calorimeter determines heats of formation of alloys at high temperatures

Science.gov (United States)

Darby, J. B., Jr.; Kleb, R.; Kleppa, O. J.

1968-01-01

Calvert-type, twin liquid metal solution calorimeter determines the heats of formation of transition metal alloys at high temperatures. The twin differential calorimeter measures the small heat effects generated over extended periods of time, has maximum operating temperature of 1073 degrees K and an automatic data recording system.

Two-Phase Microfluidic Systems for High Throughput Quantification of Agglutination Assays

KAUST Repository

Castro, David

2018-04-01

agglutination assay, and turn it into a quantitative High Sensitivity-CRP test, with a lower detection limit of 0.5 mg/L using light scattering. Agglutination assays are an incredibly versatile tool, capable of detecting an ever-growing catalog of infectious diseases, proteins and metabolites. A system such as that presented in this thesis is a step towards being able to produce high throughput microfluidic solutions with widespread adoption.

Application of polystyrene - water calorimeter in determination of absorbed dose. Vol. 4.

Energy Technology Data Exchange (ETDEWEB)

Soliman, F A [Nuclear Materials Authority, Maadi, Cairo (Egypt); Ashry, H A; El-Behay, A Z; Abdou, S [National Center, for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)

1996-03-01

The polystyrene-water calorimeter was investigated as a modification of the water calorimeter, where the polystyrene has a low specific heat and negligible known heat defect. This calorimeter was designed, constructed and calibrated for measurement of radiation absorbed dose. The system utilizes a thermistor to detect the radiation-induced temperature rise in the polystyrene absorber at certain point from the radiation source. A temperature stability of as low as 0.0018 degree C/min in a 42.0 degree C environment, and a gamma-radiation sensitivity of as high as 1.9720 ohm/Gy were obtained. Comparisons of the results obtained by using the polystyrene-water calorimeter with those obtained by applying other types of calorimeters i.e., water and graphite calorimeters were also done to aid in the possible realization of an accurate and efficient instrument for use under widely different irradiation conditions. 4 figs., 1 tab.

Modular calorimeter system for use in high energy physics

International Nuclear Information System (INIS)

Yost, B.T.; Corcoran, M.D.; Cormell, L.

1978-10-01

A modular hadron calorimeter was designed and built for the study of high energy particle interactions which produce particles of high transverse momentum. The energy resolution of this system and the triggering method for selecting the interactions of interest are described

Microfluidic Technologies for Synthetic Biology

Directory of Open Access Journals (Sweden)

Sung Kuk Lee

2011-06-01

Full Text Available Microfluidic technologies have shown powerful abilities for reducing cost, time, and labor, and at the same time, for increasing accuracy, throughput, and performance in the analysis of biological and biochemical samples compared with the conventional, macroscale instruments. Synthetic biology is an emerging field of biology and has drawn much attraction due to its potential to create novel, functional biological parts and systems for special purposes. Since it is believed that the development of synthetic biology can be accelerated through the use of microfluidic technology, in this review work we focus our discussion on the latest microfluidic technologies that can provide unprecedented means in synthetic biology for dynamic profiling of gene expression/regulation with high resolution, highly sensitive on-chip and off-chip detection of metabolites, and whole-cell analysis.

CsI Calorimeter for a Compton-Pair Telescope

Science.gov (United States)

Grove, Eric J.

We propose to build and test a hodoscopic CsI(Tl) scintillating-crystal calorimeter for a medium-energy γ-ray Compton and pair telescope. The design and technical approach for this calorimeter relies deeply on heritage from the Fermi LAT CsI Calorimeter, but it dramatically improves the low-energy performance of that design by reading out the scintillation light with silicon photomultipliers (SiPMs), making the technology developed for Fermi applicable in the Compton regime. While such a hodoscopic calorimeter is useful for an entire class of medium-energy γ-ray telescope designs, we propose to build it explicitly to support beam tests and balloon flight of the Proto-ComPair telescope, the development and construction of which was funded in a four-year APRA program beginning in 2015 ("ComPair: Steps to a Medium Energy γ-ray Mission" with PI J. McEnery of GSFC). That award did not include funding for its CsI calorimeter subsystem, and this proposal is intended to cover that gap. ComPair is a MIDEX-class instrument concept to perform a high-sensitivity survey of the γ-ray sky from 0.5 MeV to 500 MeV. ComPair is designed to provide a dramatic increase in sensitivity relative to previous instruments in this energy range (predominantly INTEGRAL/SPI and Compton COMPTEL), with the same transformative sensitivity increase - and corresponding scientific return- that the Fermi Large Area Telescope provided relative to Compton EGRET. To enable transformative science over a broad range of MeV energies and with a wide field of view, ComPair is a combined Compton telescope and pair telescope employing a silicon-strip tracker (for Compton scattering and pair conversion and tracking) and a solid-state CdZnTe calorimeter (for Compton absorption) and CsI calorimeter (for pair calorimetry), surrounded by a plastic scintillator anti-coincidence detector. Under the current proposal, we will complete the detailed design, assembly, and test of the CsI calorimeter for the risk

Development of a metallic magnetic calorimeter for high resolution spectroscopy

International Nuclear Information System (INIS)

Linck, M.

2007-01-01

In this thesis the development of a metallic magnetic calorimeter for high resolution detection of single x-ray quanta is described. The detector consists of an X-ray absorber and a paramagnetic temperature sensor. The raise in temperature of the paramagnetic sensor due to the absorption of a single X-ray is measured by the change in magnetization of the sensor using a low-noise SQUID magnetometer. The thermodynamic properties of the detector can be described by a theoretical model based on a mean field approximation. This allows for an optimization of the detector design with respect to signal size. The maximal archivable energy resolution is limited by thermodynamic energy fluctuations between absorber, heat bath and thermometer. An interesting field of application for a metallic magnetic calorimeter is X-ray astronomy and the investigation of X-ray emitting objects. Through high-resolution X-ray spectroscopy it is possible to obtain information about physical processes of even far distant objects. The magnetic calorimeter that was developed in this thesis has a metallic absorber with a quantum efficiency of 98% at 6 keV. The energy resolution of the magnetic calorimeter is EFWHM=2.7 eV at 5.9 keV. The deviation of the detector response from a linear behavior of the detector is only 0.8% at 5.9 keV. (orig.)

New high-gain thin-gap detector for the OPAL hadron calorimeter

Energy Technology Data Exchange (ETDEWEB)

Dado, S; Goldberg, J; Lupu, N; Mincer, A I; Alexander, G; Bella, G; Gnat, Y; Grunhaus, J; Levy, A; Cohen, J

1986-12-01

A new type of thin-gap multiwire gas detector operating in a high-gain mode was developed for use in the OPAL pole-tip calorimeter. The detector thickness is only 6.6 mm and its area is 0.61 m/sup 2/. The induced pad readout provides high output pulses that require no amplification. The setup for the detector mass production and quality-control test is described. Results from a test beam setup that simulates the OPAL pole-tip calorimeter are presented and compared with computer simulations.

Calorimeter probes for measuring high thermal flux. [in arc jets

Science.gov (United States)

Russell, L. D.

1979-01-01

Expendable, slug-type calorimeter probes were developed for measuring high heat-flux levels of 10-30 kW/sq cm in electric-arc jet facilities. The probes were constructed with thin tungsten caps mounted on Teflon bodies. The temperature of the back surface of the tungsten cap is measured, and its time rate of change gives the steady-state absorbed heat flux as the calorimeter probe heats to destruction when inserted into the arc jet. Design, construction, test, and performance data are presented.

Development of Microfluidic Systems Enabling High-Throughput Single-Cell Protein Characterization

OpenAIRE

Fan, Beiyuan; Li, Xiufeng; Chen, Deyong; Peng, Hongshang; Wang, Junbo; Chen, Jian

2016-01-01

This article reviews recent developments in microfluidic systems enabling high-throughput characterization of single-cell proteins. Four key perspectives of microfluidic platforms are included in this review: (1) microfluidic fluorescent flow cytometry; (2) droplet based microfluidic flow cytometry; (3) large-array micro wells (microengraving); and (4) large-array micro chambers (barcode microchips). We examine the advantages and limitations of each technique and discuss future research oppor...

Upgrade of the ATLAS hadronic Tile Calorimeter for the High luminosity LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00127668; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter of ATLAS covering the central region of the ATLAS experiment. TileCal is a sampling calorimeter with steel as absorber and scintillators as active medium. The scintillators are read-out by wavelength shifting fibers coupled to photomultiplier tubes (PMT). The analogue signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The High Luminosity Large Hadron Collider (HL-LHC) will have a peak luminosity of 5 1034cm2s1, five times higher than the design luminosity of the LHC. TileCal will undergo a major replacement of its on- and off-detector electronics for the high luminosity programme of the LHC starting in 2026. All signals will be digitized and then transferred directly to the off-detector electronics, where the signals will be reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow ...

Upgrade of the ATLAS hadronic Tile Calorimeter for the High luminosity LHC

CERN Document Server

Solodkov, Alexander; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter of ATLAS covering the central region of the ATLAS experiment. TileCal is a sampling calorimeter with steel as absorber and scintillators as active medium. The scintillators are read-out by wavelength shifting fibers coupled to photomultiplier tubes (PMT). The analogue signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The High Luminosity Large Hadron Collider (HL-LHC) will have a peak luminosity of 5x10ˆ34 cm-2s-1, five times higher than the design luminosity of the LHC. TileCal will undergo a major replacement of its on- and off-detector electronics for the high luminosity programme of the LHC starting in 2026. All signals will be digitized and then transferred directly to the off-detector electronics, where the signals will be reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will a...

The high resolution spaghetti hadron calorimeter

International Nuclear Information System (INIS)

Jenni, P.; Sonderegger, P.; Paar, H.P.; Wigmans, R.

1987-01-01

It is proposed to build a prototype for a hadron calorimeter with scintillating plastic fibres as active material. The absorber material is lead. Provided that these components are used in the appropriate volume ratio, excellent performance may be expected, e.g. an energy resolution of 30%/√E for jet detection. The proposed design offers additional advantages compared to the classical sandwich calorimeter structures in terms of granularity, hermiticity, uniformity, compactness, readout, radiation resistivity, stability and calibration. 22 refs.; 7 figs

New high gain thin gap detector for the OPAL hadron calorimeter

Energy Technology Data Exchange (ETDEWEB)

Dado, S; Goldberg, J; Lupu, N; Mincer, A I; Alexander, G; Bella, G; Gnat, Y; Grunhaus, J; Levy, A; Cohen, J

1986-12-01

A new type of thin gap multiwire gas detector operating in a high gain mode has been developed for use in the OPAL pole tip calorimeter. The detector thickness is only 6.6 mm and its area is 0.61 m/sup 2/. The induced pad readout provides high output pulses which require no amplification. The set-up for the detector mass production and quality control test is described. Results from a test beam set-up that simulates the OPAL pole tip calorimeter are presented and compared with computer simulations.

Application of the image calorimeter in the high energy gamma astronomy

Energy Technology Data Exchange (ETDEWEB)

Casolino, M.; Sparvoli, R.; Morselli, A.; Picozza, P. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `Tor Vergata`, Rome (Italy); Carlson, P. [Royal Institute of Technology, Stockholm (Sweden); Fuglesang, C. [ESA-EAC, Cologne (Germany); Ozerov, Yu.V.; Zemskov, V.M.; Zverev, V.G.; Galper, A.M. [Moscow Engineering Physics Institute, Moscow (Russian Federation)

1995-09-01

The capability of registration of the primary high energy cosmic ray gamma emission by a gamma-telescope made of an image calorimeter is shown in this paper. The problem of triggering and off-line identification of primary particles by the analysis of the electromagnetic showers induced in the calorimeter is under consideration. The estimations of the background flux of delayed secondaries induced by nuclear interactions are presented too.

Electric Characterization and Modeling of Microfluidic-Based Dye-Sensitized Solar Cell

Directory of Open Access Journals (Sweden)

Adriano Sacco

2012-01-01

Full Text Available The electric response to an external periodic voltage of small amplitude of dye-sensitized solar cells (DSCs made up with an alternative architecture has been investigated. DSCs have been fabricated with a reversible sealing structure, based on microfluidic concepts, with a precise control on the geometric parameters of the active chamber. Cells with different electrolyte thicknesses have been characterized, without varying the thickness of the TiO2 layer, both under illumination and in dark conditions. Measurements of the electric impedance have been performed in the presence of an external bias ranging from 0 V to 0.8 V. The experimental data have been analyzed in terms of a transmission line model, with two transport channels. The results show that the photovoltaic performances of the microfluidic cell are comparable with those obtained in irreversibly sealed structures, actually demonstrating the reliability of the proposed device.

Fast and sensitive detection of foodborne pathogen using electrochemical impedance analysis, urease catalysis and microfluidics.

Science.gov (United States)

Chen, Qi; Wang, Dan; Cai, Gaozhe; Xiong, Yonghua; Li, Yuntao; Wang, Maohua; Huo, Huiling; Lin, Jianhan

2016-12-15

Early screening of pathogenic bacteria is a key to prevent and control of foodborne diseases. In this study, we developed a fast and sensitive bacteria detection method integrating electrochemical impedance analysis, urease catalysis with microfluidics and using Listeria as model. The Listeria cells, the anti-Listeria monoclonal antibodies modified magnetic nanoparticles (MNPs), and the anti-Listeria polyclonal antibodies and urease modified gold nanoparticles (AuNPs) were incubated in a fluidic separation chip with active mixing to form the MNP-Listeria-AuNP-urease sandwich complexes. The complexes were captured in the separation chip by applying a high gradient magnetic field, and the urea was injected to resuspend the complexes and hydrolyzed under the catalysis of the urease on the complexes into ammonium ions and carbonate ions, which were transported into a microfluidic detection chip with an interdigitated microelectrode for impedance measurement to determine the amount of the Listeria cells. The capture efficiency of the Listeria cells in the separation chip was ∼93% with a shorter time of 30min due to the faster immuno-reaction using the active magnetic mixing. The changes on both impedance magnitude and phase angle were demonstrated to be able to detect the Listeria cells as low as 1.6×10(2)CFU/mL. The detection time was reduced from original ∼2h to current ∼1h. The recoveries of the spiked lettuce samples ranged from 82.1% to 89.6%, indicating the applicability of this proposed biosensor. This microfluidic impedance biosensor has shown the potential for online, automatic and sensitive bacteria separation and detection. Copyright © 2016 Elsevier B.V. All rights reserved.

Concepts and design of the CMS high granularity calorimeter Level-1 trigger

CERN Document Server

Sauvan, Jean-Baptiste

2016-01-01

The CMS experiment has chosen a novel high granularity calorimeter for the forward region as part of its planned upgrade for the high luminosity LHC. The calorimeter will have a fine segmentation in both the transverse and longitudinal directions and will be the first such calorimeter specifically optimised for particle flow reconstruction to operate at a colliding beam experiment. The high granularity results in around six million readout channels in total and so presents a significant challenge in terms of data manipulation and processing for the trigger; the trigger data volumes will be an order of magnitude above those currently handled at CMS. In addition, the high luminosity will result in an average of 140 to 200 interactions per bunch crossing, giving a huge background rate in the forward region that needs to be efficiently reduced by the trigger algorithms. Efficient data reduction and reconstruction algorithms making use of the fine segmentation of the detector have been simulated and evaluated. The...

Principal component analysis for neural electron/jet discrimination in highly segmented calorimeters

International Nuclear Information System (INIS)

Vassali, M.R.; Seixas, J.M.

2001-01-01

A neural electron/jet discriminator based on calorimetry is developed for the second-level trigger system of the ATLAS detector. As preprocessing of the calorimeter information, a principal component analysis is performed on each segment of the two sections (electromagnetic and hadronic) of the calorimeter system, in order to reduce significantly the dimension of the input data space and fully explore the detailed energy deposition profile, which is provided by the highly-segmented calorimeter system. It is shown that projecting calorimeter data onto 33 segmented principal components, the discrimination efficiency of the neural classifier reaches 98.9% for electrons (with only 1% of false alarm probability). Furthermore, restricting data projection onto only 9 components, an electron efficiency of 99.1% is achieved (with 3% of false alarm), which confirms that a fast triggering system may be designed using few components

Calorimeter based detectors for high energy hadron colliders

International Nuclear Information System (INIS)

Marx, M.D.; Rijssenbeek, M.

1990-01-01

This report discusses the following topics: the central calorimeter; and installation; commissioning; and calorimeter beam tests; the central drift chamber; cosmic ray and beam tests; chamber installation and commissioning; and software development; and SSC activities: the EMPACT project

The ATLAS Level-1 Calorimeter Trigger

International Nuclear Information System (INIS)

Achenbach, R; Andrei, V; Adragna, P; Apostologlou, P; Barnett, B M; Brawn, I P; Davis, A O; Edwards, J P; Asman, B; Bohm, C; Ay, C; Bauss, B; Bendel, M; Dahlhoff, A; Eckweiler, S; Booth, J R A; Thomas, P Bright; Charlton, D G; Collins, N J; Curtis, C J

2008-01-01

The ATLAS Level-1 Calorimeter Trigger uses reduced-granularity information from all the ATLAS calorimeters to search for high transverse-energy electrons, photons, τ leptons and jets, as well as high missing and total transverse energy. The calorimeter trigger electronics has a fixed latency of about 1 μs, using programmable custom-built digital electronics. This paper describes the Calorimeter Trigger hardware, as installed in the ATLAS electronics cavern

The ATLAS Level-1 Calorimeter Trigger

Energy Technology Data Exchange (ETDEWEB)

Achenbach, R; Andrei, V [Kirchhoff-Institut fuer Physik, University of Heidelberg, D-69120 Heidelberg (Germany); Adragna, P [Physics Department, Queen Mary, University of London, London E1 4NS (United Kingdom); Apostologlou, P; Barnett, B M; Brawn, I P; Davis, A O; Edwards, J P [STFC Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxon OX11 0QX (United Kingdom); Asman, B; Bohm, C [Fysikum, Stockholm University, SE-106 91 Stockholm (Sweden); Ay, C; Bauss, B; Bendel, M; Dahlhoff, A; Eckweiler, S [Institut fuer Physik, University of Mainz, D-55099 Mainz (Germany); Booth, J R A; Thomas, P Bright; Charlton, D G; Collins, N J; Curtis, C J [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom)], E-mail: e.eisenhandler@qmul.ac.uk (and others)

2008-03-15

The ATLAS Level-1 Calorimeter Trigger uses reduced-granularity information from all the ATLAS calorimeters to search for high transverse-energy electrons, photons, {tau} leptons and jets, as well as high missing and total transverse energy. The calorimeter trigger electronics has a fixed latency of about 1 {mu}s, using programmable custom-built digital electronics. This paper describes the Calorimeter Trigger hardware, as installed in the ATLAS electronics cavern.

X-Ray Calorimeter Arrays for Astrophysics

Science.gov (United States)

Kilbourne, Caroline A.

2009-01-01

High-resolution x-ray spectroscopy is a powerful tool for studying the evolving universe. The grating spectrometers on the XMM and Chandra satellites started a new era in x-ray astronomy, but there remains a need for instrumentation that can provide higher spectral resolution with high throughput in the Fe-K band (around 6 keV) and can enable imaging spectroscopy of extended sources, such as supernova remnants and galaxy clusters. The instrumentation needed is a broad-band imaging spectrometer - basically an x-ray camera that can distinguish tens of thousands of x-ray colors. The potential benefits to astrophysics of using a low-temperature calorimeter to determine the energy of an incident x-ray photon via measurement of a small change in temperature was first articulated by S. H. Moseley over two decades ago. In the time since, technological progress has been steady, though full realization in an orbiting x-ray telescope is still awaited. A low-temperature calorimeter can be characterized by the type of thermometer it uses, and three types presently dominate the field. The first two types are temperature-sensitive resistors - semiconductors in the metal-insulator transition and superconductors operated in the superconducting-normal transition. The third type uses a paramagnetic thermometer. These types can be considered the three generations of x-ray calorimeters; by now each has demonstrated a resolving power of 2000 at 6 keV, but only a semiconductor calorimeter system has been developed to spaceflight readiness. The Soft X-ray Spectrometer on Astro-H, expected to launch in 2013, will use an array of silicon thermistors with I-IgTe x-ray absorbers that will operate at 50 mK. Both the semiconductor and superconductor calorimeters have been implemented in small arrays, kilo-pixel arrays of the superconducting calorimeters are just now being produced, and it is anticipated that much larger arrays will require the non-dissipative advantage of magnetic thermometers.

Paper-based microfluidic approach for surface-enhanced raman spectroscopy and highly reproducible detection of proteins beyond picomolar concentration.

Science.gov (United States)

Saha, Arindam; Jana, Nikhil R

2015-01-14

Although microfluidic approach is widely used in various point of care diagnostics, its implementation in surface enhanced Raman spectroscopy (SERS)-based detection is challenging. This is because SERS signal depends on plasmonic nanoparticle aggregation induced generation of stable electromagnetic hot spots and in currently available microfluidic platform this condition is difficult to adapt. Here we show that SERS can be adapted using simple paper based microfluidic system where both the plasmonic nanomaterials and analyte are used in mobile phase. This approach allows analyte induced controlled particle aggregation and electromagnetic hot spot generation inside the microfluidic channel with the resultant SERS signal, which is highly reproducible and sensitive. This approach has been used for reproducible detection of protein in the pico to femtomolar concentration. Presented approach is simple, rapid, and cost-effective, and requires low sample volume. Method can be extended for SERS-based detection of other biomolecules.

Fabrication of a microfluidic chip by UV bonding at room temperature for integration of temperature-sensitive layers

Science.gov (United States)

Schlautmann, S.; Besselink, G. A. J.; Radhakrishna Prabhu, G.; Schasfoort, R. B. M.

2003-07-01

A method for the bonding of a microfluidic device at room temperature is presented. The wafer with the fluidic structures was bonded to a sensor wafer with gold pads by means of adhesive bonding, utilizing an UV-curable glue layer. To avoid filling the fluidic channels with the glue, a stamping process was developed which allows the selective application of a thin glue layer. In this way a microfluidic glass chip was fabricated that could be used for performing surface plasmon resonance measurements without signs of leakage. The advantage of this method is the possibility of integration of organic layers as well as other temperature-sensitive layers into a microfluidic glass device.

Microfluidic high gradient magnetic cell separation

Science.gov (United States)

Inglis, David W.; Riehn, Robert; Sturm, James C.; Austin, Robert H.

2006-04-01

Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

Fluorescence detection system for microfluidic droplets

Science.gov (United States)

Chen, Binyu; Han, Xiaoming; Su, Zhen; Liu, Quanjun

2018-05-01

In microfluidic detection technology, because of the universality of optical methods in laboratory, optical detection is an attractive solution for microfluidic chip laboratory equipment. In addition, the equipment with high stability and low cost can be realized by integrating appropriate optical detection technology on the chip. This paper reports a detection system for microfluidic droplets. Photomultiplier tubes (PMT) is used as a detection device to improve the sensitivity of detection. This system improves the signal to noise ratio by software filtering and spatial filter. The fluorescence intensity is proportional to the concentration of the fluorescence and intensity of the laser. The fluorescence micro droplets of different concentrations can be distinguished by this system.

Design, Performance and Calibration of the CMS Forward Calorimeter Wedges

CERN Document Server

Baiatian, G; Emeliantchik, Igor; Massolov, V; Shumeiko, Nikolai; Stefanovich, R; Damgov, Jordan; Dimitrov, Lubomir; Genchev, Vladimir; Piperov, Stefan; Vankov, Ivan; Litov, Leander; Bencze, Gyorgy; Laszlo, Andras; Pal, Andras; Vesztergombi, Gyorgy; Zálán, Peter; Fenyvesi, Andras; Bawa, Harinder Singh; Beri, Suman Bala; Bhatnager, V; Kaur, Manjit; Kumar, Arun; Kohli, Jatinder Mohan; Singh, Jas Bir; Acharya, Bannaje Sripathi; Chendvankar, Sanjay; Dugad, Shashikant; Kalmani, Suresh Devendrappa; Katta, S; Mazumdar, Kajari; Mondal, Naba Kumar; Nagaraj, P; Patil, Mandakini Ravindra; Reddy, L V; Satyanarayana, B; Sharma, Seema; Verma, Piyush; Hashemi, Majid; Mohammadi-Najafabadi, M; Paktinat, S; Babich, Kanstantsin; Golutvin, Igor; Kalagin, Vladimir; Kosarev, Ivan; Ladygin, Vladimir; Meshcheryakov, Gleb; Moissenz, P; Petrosian, A; Rogalev, Evgueni; Sergeyev, S; Smirnov, Vitaly; Vishnevski, A V; Volodko, Anton; Zarubin, Anatoli; Gavrilov, Vladimir; Gershtein, Yuri; Ilyina, N P; Kaftanov, Vitali; Kisselevich, I; Kolossov, V; Krokhotin, Andrey; Kuleshov, Sergey; Litvintsev, Dmitri; Oulyanov, A; Safronov, S; Semenov, Sergey; Stolin, Viatcheslav; Gribushin, Andrey; Demianov, A; Kodolova, Olga; Petrushanko, Sergey; Sarycheva, Ludmila; Teplov, Konstantin; Vardanyan, Irina; Yershov, A A; Abramov, Victor; Goncharov, Petr; Kalinin, Alexey; Korablev, Andrey; Khmelnikov, V A; Korneev, Yury; Krinitsyn, Alexander; Kryshkin, V; Lukanin, Vladimir; Pikalov, Vladimir; Ryazanov, Anton; Talov, Vladimir; Turchanovich, L K; Volkov, Alexey; Camporesi, Tiziano; De Visser, Theo; Vlassov, E; Aydin, Sezgin; Bakirci, Mustafa Numan; Cerci, Salim; Dumanoglu, Isa; Eskut, Eda; Kayis-Topaksu, A; Koylu, S; Kurt, Pelin; Kuzucu, A; Onengüt, G; Ozdes-Koca, N; Ozkurt, Halil; Sogut, Kenan; Topakli, Huseyin; Vergili, Mehmet; Yetkin, Taylan; Cankocak, Kerem; Gamsizkan, Halil; Ozkan, Cigdem; Sekmen, Sezen; Serin-Zeyrek, M; Sever, Ramazan; Yazgan, Efe; Zeyrek, Mehmet; Deliomeroglu, Mehmet; Dindar, Kamile; Gülmez, Erhan; Isiksal, Engin; Kaya, Mithat; Ozkorucuklu, Suat; Levchuk, Leonid; Sorokin, Pavel; Grinev, B; Lubinsky, V; Senchyshyn, Vitaliy; Anderson, E Walter; Hauptman, John M; Elias, John E; Freeman, Jim; Green, Dan; Heering, Arjan Hendrix; Lazic, Dragoslav; Los, Serguei; Ronzhin, Anatoly; Suzuki, Ichiro; Vidal, Richard; Whitmore, Juliana; Antchev, Georgy; Arcidy, M; Hazen, Eric; Lawlor, C; Machado, Emanuel; Posch, C; Rohlf, James; Sulak, Lawrence; Varela, F; Wu, Shouxiang; Adams, Mark Raymond; Burchesky, Kyle; Qiang, W; Abdullin, Salavat; Baden, Drew; Bard, Robert; Eno, Sarah Catherine; Grassi, Tullio; Jarvis, Chad; Kellogg, Richard G; Kunori, Shuichi; Mans, Jeremy; Skuja, Andris; Wang, Lei; Wetstein, Matthew; Ayan, S; Akgun, Ugur; Duru, Firdevs; Merlo, Jean-Pierre; Mestvirishvili, Alexi; Miller, Michael; Norbeck, Edwin; Olson, Jonathan; Onel, Yasar; Schmidt, Ianos; Akchurin, Nural; Carrell, Kenneth Wayne; Gumus, Kazim; Kim, Heejong; Spezziga, Mario; Thomas, Ray; Wigmans, Richard; Baarmand, Marc M; Mermerkaya, Hamit; Vodopyanov, I; Kramer, Laird; Linn, Stephan; Markowitz, Pete; Martínez, German; Cushman, Priscilla; Ma, Yousi; Sherwood, Brian; Cremaldi, Lucien Marcus; Reidy, Jim; Sanders, David A; Fisher, Wade Cameron; Tully, Christopher; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Barnes, Virgil E; Laasanen, Alvin T; Pompos, Arnold

2008-01-01

We report on the test beam results and calibration methods using charged particles of the CMS Forward Calorimeter (HF). The HF calorimeter covers a large pseudorapidity region (3\\l |\\eta| \\le 5), and is essential for large number of physics channels with missing transverse energy. It is also expected to play a prominent role in the measurement of forward tagging jets in weak boson fusion channels. The HF calorimeter is based on steel absorber with embedded fused-silica-core optical fibers where Cherenkov radiation forms the basis of signal generation. Thus, the detector is essentially sensitive only to the electromagnetic shower core and is highly non-compensating (e/h \\approx 5). This feature is also manifest in narrow and relatively short showers compared to similar calorimeters based on ionization. The choice of fused-silica optical fibers as active material is dictated by its exceptional radiation hardness. The electromagnetic energy resolution is dominated by photoelectron statistics and can be expressed...

Upgrade of the ATLAS Hadronic Tile Calorimeter for the High Luminosity LHC

CERN Document Server

Hildebrand, Kevin; The ATLAS collaboration

2017-01-01

The Tile Calorimeter is the hadronic calorimeter covering the central region of the ATLAS detector at the Large Hadron Collider. It is a scintillator-steel sampling calorimeter read out via wavelength shifting fibers coupled to photomultiplier tubes (PMT). The PMT signals are digitized and stored on detector until a trigger is received. The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade (2024-2025) will accommodate the upgrade of the detector and data acquisition system for the HL-LHC. In particular, TileCal will undergo a major replacement of its on- and off-detector electronics. In the new architecture, all signals will be digitized and then transferred directly to the off-detector electronics, where the signals will be reconstructed, stored, and sent to the first level of trigger at the rate of 40 MHz. This will provide better precision of the calorimeter signals...

Upgrade of the ATLAS Hadronic Tile Calorimeter for the High Luminosity LHC

CERN Document Server

Hildebrand, Kevin; The ATLAS collaboration

2017-01-01

The Tile Calorimeter is the hadronic calorimeter covering the central region of the ATLAS detector at the Large Hadron Collider. It is a scintillator-steel sampling calorimeter read out via wavelength shifting fibers coupled to photomultiplier tubes (PMT). . The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade (2024-2025) will accommodate the upgrade of the detector and data acquisition system for the HL-LHC. In particular, TileCal will undergo a major replacement of its on- and off-detector electronics. In the new architecture, all signals will be digitized and sent to the first level of trigger at the rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Changes to the electronics will also contribute to the reliability and redundancy of the system. ...

Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement

DEFF Research Database (Denmark)

Juul, Sissel; Nielsen, Christine Juul Fælled; Labouriau, Rodrigo

2012-01-01

detectable at the single-molecule level. Combined with a droplet microfluidics lab-on-a-chip platform, this design allowed for sensitive, specific, and quantitative detection of all human-malaria-causing Plasmodium species in single drops of unprocessed blood with a detection limit of less than one parasite....../μL. Moreover, the setup allowed for detection of Plasmodium parasites in noninvasive saliva samples from infected patients. During recent years malaria transmission has declined worldwide, and with this the number of patients with low-parasite density has increased. Consequently, the need for accurate...

The CMS High-Granularity Calorimeter (HGCAL) for Operation at the High-Luminosity LHC

CERN Document Server

Pitters, Florian Michael

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm^2 cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors will...

Advanced Thin Ionization Calorimeter (ATIC)

Science.gov (United States)

Wefel, John P.

1998-01-01

This is the final report for NASA grant NAGW-4577, "Advanced Thin Ionization Calorimeter (ATIC)". This grant covered a joint project between LSU and the University of Maryland for a Concept Study of a new type of fully active calorimeter to be used to measure the energy spectra of very high energy cosmic rays, particularly Hydrogen and Helium, to beyond 1014 eV. This very high energy region has been studied with emulsion chamber techniques, but never investigated with electronic calorimeters. Technology had advanced to the point that a fully active calorimeter based upon Bismuth Germanate (BGO) scintillating crystals appeared feasible for balloon flight (and eventually space) experiments.

Immobilization of pH-sensitive CdTe Quantum Dots in a Poly(acrylate) Hydrogel for Microfluidic Applications

Science.gov (United States)

Franke, M.; Leubner, S.; Dubavik, A.; George, A.; Savchenko, T.; Pini, C.; Frank, P.; Melnikau, D.; Rakovich, Y.; Gaponik, N.; Eychmüller, A.; Richter, A.

2017-04-01

Microfluidic devices present the basis of modern life sciences and chemical information processing. To control the flow and to allow optical readout, a reliable sensor material that can be easily utilized for microfluidic systems is in demand. Here, we present a new optical readout system for pH sensing based on pH sensitive, photoluminescent glutathione capped cadmium telluride quantum dots that are covalently immobilized in a poly(acrylate) hydrogel. For an applicable pH sensing the generated hybrid material is integrated in a microfluidic sensor chip setup. The hybrid material not only allows in situ readout, but also possesses valve properties due to the swelling behavior of the poly(acrylate) hydrogel. In this work, the swelling property of the hybrid material is utilized in a microfluidic valve seat, where a valve opening process is demonstrated by a fluid flow change and in situ monitored by photoluminescence quenching. This discrete photoluminescence detection (ON/OFF) of the fluid flow change (OFF/ON) enables upcoming chemical information processing.

Upgrade of the ATLAS Tile Calorimeter for the High Luminosity LHC

CERN Document Server

Scuri, Fabrizio; The ATLAS collaboration

2018-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS experiment. TileCal is a sampling calorimeter with steel as absorber and scintillators as active medium. The scintillators are read-out by wavelength shifting fibers coupled to photomultiplier tubes (PMTs). The analogue signals from the PMTs are amplified, shaped, digitized by sampling the signal every 25 ns and stored on detector until a trigger decision is received. The High-Luminosity phase of LHC (HL-LHC) expected to begin in year 2026 requires new electronics to meet the requirements of a 1 MHz trigger, higher ambient radiation, and for better performance under high pileup. Both the on- and off-detector TileCal electronics will be replaced during the shutdown of 2024-2025. PMT signals from every TileCal cell will be digitized and sent directly to the back-end electronics, where the signals are reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precis...

In-depth analysis and discussions of water absorption-typed high power laser calorimeter

Science.gov (United States)

Wei, Ji Feng

2017-02-01

In high-power and high-energy laser measurement, the absorber materials can be easily destroyed under long-term direct laser irradiation. In order to improve the calorimeter's measuring capacity, a measuring system directly using water flow as the absorber medium was built. The system's basic principles and the designing parameters of major parts were elaborated. The system's measuring capacity, the laser working modes, and the effects of major parameters were analyzed deeply. Moreover, the factors that may affect the accuracy of measurement were analyzed and discussed. The specific control measures and methods were elaborated. The self-calibration and normal calibration experiments show that this calorimeter has very high accuracy. In electrical calibration, the average correction coefficient is only 1.015, with standard deviation of only 0.5%. In calibration experiments, the standard deviation relative to a middle-power standard calorimeter is only 1.9%.

Micro Calorimeter for Batteries

Energy Technology Data Exchange (ETDEWEB)

Santhanagopalan, Shriram [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2017-08-01

As battery technology forges ahead and consumer demand for safer, more affordable, high-performance batteries grows, the National Renewable Energy Laboratory (NREL) has added a patented Micro Calorimeter to its existing family of R&D 100 Award-winning Isothermal Battery Calorimeters (IBCs). The Micro Calorimeter examines the thermal signature of battery chemistries early on in the design cycle using popular coin cell and small pouch cell designs, which are simple to fabricate and study.

Precision titration mini-calorimeter

International Nuclear Information System (INIS)

Ensor, D.; Kullberg, L.; Choppin, G.

1977-01-01

The design and test of a small volume calorimeter of high precision and simple design is described. The calorimeter operates with solution sample volumes in the range of 3 to 5 ml. The results of experiments on the entropy changes for two standard reactions: (1) reaction of tris(hydroxymethyl)aminomethane with hydrochloric acid and (2) reaction between mercury(II) and bromide ions are reported to confirm the accuracy and overall performance of the calorimeter

High-Throughput Fabrication of Nanocone Substrates through Polymer Injection Moulding For SERS Analysis in Microfluidic Systems

DEFF Research Database (Denmark)

Viehrig, Marlitt; Matteucci, Marco; Thilsted, Anil H.

analysis. Metal-capped silicon nanopillars, fabricated through a maskless ion etch, are state-of-the-art for on-chip SERS substrates. A dense cluster of high aspect ratio polymer nanocones was achieved by using high-throughput polymer injection moulding over a large area replicating a silicon nanopillar...... structure. Gold-capped polymer nanocones display similar SERS sensitivity as silicon nanopillars, while being easily integrable into a microfluidic chips....

Meta-atom microfluidic sensor for measurement of dielectric properties of liquids

Science.gov (United States)

Awang, Robiatun A.; Tovar-Lopez, Francisco J.; Baum, Thomas; Sriram, Sharath; Rowe, Wayne S. T.

2017-03-01

High sensitivity microwave frequency microfluidic sensing is gaining popularity in chemical and biosensing applications for evaluating the dielectric properties of liquid samples. Here, we show that a tiny microfluidic channel positioned in the gaps of a dual-gap meta-atom split-ring resonator can exploit the electric field sensitivity to predict the dielectric properties of liquid samples. Employing an empirical relation between resonant characteristics of the fabricated sensor and the complex permittivity of water-ethanol or water-methanol mixtures produces good congruence to standardized values from the literature. This microfluidic sensor offers a potential lab-on-chip solution for liquid dielectric characterization without external electrical connections.

Electronics and triggering challenges for the CMS High Granularity Calorimeter

CERN Document Server

Lobanov, Artur

2017-01-01

The High Granularity Calorimeter (HGCAL), presently being designed by the CMS collaboration to replace the CMS endcap calorimeters for the High Luminosity phase of LHC, will feature six million channels distributed over 52 longitudinal layers. The requirements for the front-end electronics are extremely challenging, including high dynamic range (0-10 pC), low noise (~2000e- to be able to calibrate on single minimum ionising particles throughout the detector lifetime) and low power consumption (~10mW/channel), as well as the need to select and transmit trigger information with a high granularity. Exploiting the intrinsic precision-timing capabilities of silicon sensors also requires careful design of the front-end electronics as well as the whole system, particularly clock distribution. The harsh radiation environment and requirement to keep the whole detector as dense as possible will require novel solutions to the on-detector electronics layout. Processing all the data from the HGCAL imposes equally large ch...

The Mu2e crystal calorimeter and improvements in the $\\mu^-\\mbox{N} \\to e^-\\mbox{N}$ search sensitivity

Energy Technology Data Exchange (ETDEWEB)

Pezzullo, Gianantonio [Univ. of Pisa (Italy)

2016-01-01

The Mu2e experiment will search for Charged Lepton Flavor Violation (CLFV) looking at the conversion of a muon into an electron in the field of an aluminum nucleus. About $7\\cdot 10^{17}$ muons, provided by a dedicated muon beam line in construction at the Fermi National Accelarator Laboratory (Fermilab), will be stopped in 3 years in the Aluminum target. The corresponding single event sensitivity will be $2.5\\cdot 10^{-17}$. The Standard Model of particle physics, even extendend to include the finite neutrino masses, predicts the ratio R_μe between muon conversions and muon nuclear captures to be $\\sim 10^{- 52}$. Several extensions of the Standard Model predict R_μe to be in the range of $10^{-14} - 10^{-18}$. % The current best experimental limit, set by the SINDRUM II experiment is $7 \\cdot 10^{-13}$ @ $90\\%$ CL. The Mu2e experiment plans to improve this experimental limit by four order of magnitude to test many of the possible extensions of the Standard Model. To reach this ambitious goal, the Mu2e experiment is expected to use an intense pulsed muon beam, and rely on a detector system composed of a straw tube tracker and a calorimeter made of pure CsI crystals. The calorimeter plays a central role in the Mu2e measurement, providing particle identification capabilities that are necessary for rejecting two of the most dangerous background sources that can mimic the μ⁻N → e⁻N conversion electron: cosmic muons and $\\bar{p}$ induced background. The calorimeter information allows also to improve the tracking performance. Thanks to a calorimeter-seeded track finder algorithm, it is possible to increase the track reconstruction efficiency, and make it more robust with respect to the occupancy level. Expected performances of the calorimeter have been studied in a beam test at the Beam Test Facility in Frascati (Rome, Italy). A reduced scale calorimeter prototype has been exposed to an electron beam, with energy varying from 80 to 140

The CMS Outer Hadron Calorimeter

CERN Document Server

Acharya, Bannaje Sripathi; Banerjee, Sunanda; Banerjee, Sudeshna; Bawa, Harinder Singh; Beri, Suman Bala; Bhandari, Virender; Bhatnagar, Vipin; Chendvankar, Sanjay; Deshpande, Pandurang Vishnu; Dugad, Shashikant; Ganguli, Som N; Guchait, Monoranjan; Gurtu, Atul; Kalmani, Suresh Devendrappa; Kaur, Manjit; Kohli, Jatinder Mohan; Krishnaswamy, Marthi Ramaswamy; Kumar, Arun; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Mondal, Naba Kumar; Nagaraj, P; Narasimham, Vemuri Syamala; Patil, Mandakini Ravindra; Reddy, L V; Satyanarayana, B; Sharma, Seema; Singh, B; Singh, Jas Bir; Sudhakar, Katta; Tonwar, Suresh C; Verma, Piyush

2006-01-01

The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with a outer calorimeter to ensure high energy shower containment in CMS and thus working as a tail catcher. Fabrication, testing and calibrations of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing $\\et$ measurements at LHC energies. The outer hadron calorimeter has a very good signal to background ratio even for a minimum ionising particle and can hence be used in coincidence with the Resistive Plate Chambers of the CMS detector for the muon trigger.

Design, construction and beam tests of the high resolution uranium scintillator calorimeter for ZEUS

International Nuclear Information System (INIS)

Straver, J.A.

1991-01-01

HERA will collide protons and electrons with energies up to 820 GeV and 30 GeV respectively. Therefore it allows measurements at momentum transfers (Q) which greatly surpass the investigations carried out so far. This extended range in Q will allow investigation of the interactions between the quarks and leptons at a distance scale of the order of 10 -18 cm. Two detectors are foreseen at HERA H1 and ZEUS. The design of the ZEUS detector is optimized for the study of neutral and charged current interactions. A calorimeter is a detector which absorbs the total incident energy of a particle while generating a signal proportional to this energy. The ZEUS calorimeter is built of alternating layers of dense absorber plates ( 238 U) and active layers of scintillator material with a fast readout system via wavelength shifters, light guides and photomultiplyers. The main subject of this thesis is the description of this calorimeter and its performance. After a short introduction to HERA and the physics topics, the importance of the quality of a calorimeter is pointed out and a brief overview of the ZEUS detector is given. In ch. 3 the principles of high resolution hadron calorimetry and the studies which led to the design of the ZEUS-calorimeter are discussed. Ch. 4 describes the mechanical design of the ZEUS forward calorimeter, the mechanical finite element calculations, and the production of the calorimeter modules at NIKHEF. Finally ch. 6 and 5 show the results of beam tests of the ZEUS forward calorimeter prototypes and the final full size forward calorimeter modules. (author). 59 refs.; 115 figs.; 29 tabs

Sensing disks for slug-type calorimeters have higher temperature stability

Science.gov (United States)

1967-01-01

Graphite sensing disk for slug-type radiation calorimeters exhibits better performance at high temperatures than copper and nickel disks. The graphite is heat-soaked to stabilize its emittance and the thermocouple is protected from the graphite so repeated temperature cycling does not change its sensitivity.

Upgrade of the ATLAS hadronic Tile Calorimeter for the High luminosity LHC

CERN Document Server

Rodriguez Bosca, Sergi; The ATLAS collaboration

2017-01-01

The Tile Calorimeter is the hadronic calorimeter covering the central region of the ATLAS detector at the Large Hadron Collider. It is a scintillator-steel sampling calorimeter read out via wavelength shifting fibers coupled to photomultiplier tubes (PMT). The PMT signals are digitized and stored on detector until a trigger is received. The High-Luminosity phase of LHC (HL-LHC) expected to begin in year 2026 requires new electronics to meet the requirements of a 1 MHz trigger, higher ambient radiation, and for better performance under higher pileup. All the TileCal on- and off-detector electronics will be replaced during the shutdown of 2024-2025. PMT signals from every TileCal cell will be digitized and sent directly to the back-end electronics, where the signals are reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Change...

Upgrade of the ATLAS hadronic Tile Calorimeter for the High luminosity LHC

CERN Document Server

Rodriguez Bosca, Sergi; The ATLAS collaboration

2017-01-01

The Tile Calorimeter is the hadronic calorimeter covering the central region of the ATLAS detector at the Large Hadron Collider. It is a scintillator-steel sampling calorimeter read out via wavelength shifting fibers coupled to photomultiplier tubes (PMT). The PMT signals are digitized and stored on detector until a trigger is received. The High-Luminosity phase of LHC (HL-LHC)expected to begin in year 2026 requires new electronics to meet the requirements of a 1 MHz trigger, higher ambient radiation, and for better performance under higher pileup. All the TileCal on- and off-detector electronics will be replaced during the shutdown of 2024-2025. PMT signals from every TileCal cell will be digitized and sent directly to the back-end electronics, where the signals are reconstructed, stored, and sent to the first level of trigger at a rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Changes...

Performance of a highly segmented scintillating fibres electromagnetic calorimeter

International Nuclear Information System (INIS)

Asmone, A.; Bertino, M.; Bini, C.; De Zorzi, G.; Diambrini Palazzi, G.; Di Cosimo, G.; Di Domenico, A.; Garufi, F.; Gauzzi, P.; Zanello, D.

1993-01-01

A prototype of scintillating fibres electromagnetic calorimeter has been constructed and tested with 2, 4 and 8 GeV electron beams at the CERN PS. The calorimeter modules consist of a Bi-Pb-Sn alloy and scintillating fibres. The fibres are parallel to the modules longer axis, and nearly parallel to the incident electrons direction. The calorimeter has two different segmentation regions of 24x24 mm 2 and 8x24 mm 2 cross area respectively. Results on energy and impact point space resolution are obtained and compared for the two different granularities. (orig.)

Design, status and perspective of the Mu2e crystal calorimeter

Energy Technology Data Exchange (ETDEWEB)

Pezzullo, G. [INFN sezione di Pisa (Italy); Atanov, N. [Joint Institute for Nuclear Research, Dubna (Russia); Baranov, V. [Joint Institute for Nuclear Research, Dubna (Russia); Budagov, J. [Joint Institute for Nuclear Research, Dubna (Russia); Cervelli, F. [INFN sezione di Pisa (Italy); Colao, F. [INFN Laboratori Nazionali di Frascati (Italy); Diociaiuti, E. [INFN Laboratori Nazionali di Frascati (Italy); Cordelli, M. [INFN Laboratori Nazionali di Frascati (Italy); Dane, E. [INFN Laboratori Nazionali di Frascati (Italy); Davydov, Yu. [Joint Institute for Nuclear Research, Dubna (Russia); Donati, S. [Univ. of Pisa (Italy); INFN sezione di Pisa (Italy); Donghia, R. [INFN Laboratori Nazionali di Frascati (Italy); Di Falco, S. [INFN sezione di Pisa (Italy); Echenard, B. [California Inst. of Technology (CalTech), Pasadena, CA (United States). Departement of Physics; Morescalchi, L. [INFN sezione di Pisa (Italy); Giovannella, S. [INFN Laboratori Nazionali di Frascati (Italy); Glagolev, V. [Joint Institute for Nuclear Research, Dubna (Russia); Grancagnolo, F. [INFN sezione di Lecce (Italy); Happacher, F. [INFN Laboratori Nazionali di Frascati (Italy); Hitlin, D. [California Inst. of Technology (CalTech), Pasadena, CA (United States). Departement of Physics; Martini, M. [INFN Laboratori Nazionali di Frascati (Italy); Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Miscetti, S. [INFN Laboratori Nazionali di Frascati (Italy); Miyashita, T. [California Inst. of Technology (CalTech), Pasadena, CA (United States). Departement of Physics; Murat, P. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pedreschi, E. [INFN sezione di Pisa (Italy); Porter, F. [California Inst. of Technology (CalTech), Pasadena, CA (United States). Departement of Physics; Raffaelli, F. [INFN sezione di Pisa (Italy); Ricci, M. [INFN Laboratori Nazionali di Frascati (Italy); Saputi, A. [INFN Laboratori Nazionali di Frascati (Italy); Sarra, I. [INFN Laboratori Nazionali di Frascati (Italy); Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Spinella, F. [INFN sezione di Pisa (Italy); Tassielli, G. [INFN sezione di Lecce (Italy); Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russia); Zhu, R. Y. [California Inst. of Technology (CalTech), Pasadena, CA (United States)

2018-01-09

The Mu2e experiment at Fermilab will search for the charged lepton flavor violating process of neutrino-less $\\mu \\to e$ coherent conversion in the field of an aluminum nucleus. Mu2e will reach a single event sensitivity of about $2.5\\cdot 10^{-17}$ that corresponds to four orders of magnitude improvements with respect to the current best limit. The detector system consists of a straw tube tracker and a crystal calorimeter made of undoped CsI coupled with Silicon Photomultipliers. The calorimeter was designed to be operable in a harsh environment where about 10 krad/year will be delivered in the hottest region and work in presence of 1 T magnetic field. The calorimeter role is to perform $\\mu$/e separation to suppress cosmic muons mimiking the signal, while providing a high level trigger and a seeding the track search in the tracker. Here, in this paper we present the calorimeter design and the latest R&D results.

Detection of Micrococcus Luteus Biofilm Formation in Microfluidic Environments by pH Measurement Using an Ion-Sensitive Field-Effect Transistor

Directory of Open Access Journals (Sweden)

Keiji Naruse

2013-02-01

Full Text Available Biofilm formation in microfluidic channels is difficult to detect because sampling volumes are too small for conventional turbidity measurements. To detect biofilm formation, we used an ion-sensitive field-effect transistor (ISFET measurement system to measure pH changes in small volumes of bacterial suspension. Cells of Micrococcus luteus (M. luteus were cultured in polystyrene (PS microtubes and polymethylmethacrylate (PMMA-based microfluidic channels laminated with polyvinylidene chloride. In microtubes, concentrations of bacteria and pH in the suspension were analyzed by measuring turbidity and using an ISFET sensor, respectively. In microfluidic channels containing 20 μL of bacterial suspension, we measured pH changes using the ISFET sensor and monitored biofilm formation using a microscope. We detected acidification and alkalinization phases of M. luteus from the ISFET sensor signals in both microtubes and microfluidic channels. In the alkalinization phase, after 2 day culture, dense biofilm formation was observed at the bottom of the microfluidic channels. In this study, we used an ISFET sensor to detect biofilm formation in clinical and industrial microfluidic environments by detecting alkalinization of the culture medium.

Detection of Micrococcus luteus biofilm formation in microfluidic environments by pH measurement using an ion-sensitive field-effect transistor.

Science.gov (United States)

Matsuura, Koji; Asano, Yuka; Yamada, Akira; Naruse, Keiji

2013-02-18

Biofilm formation in microfluidic channels is difficult to detect because sampling volumes are too small for conventional turbidity measurements. To detect biofilm formation, we used an ion-sensitive field-effect transistor (ISFET) measurement system to measure pH changes in small volumes of bacterial suspension. Cells of Micrococcus luteus (M. luteus) were cultured in polystyrene (PS) microtubes and polymethylmethacrylate (PMMA)-based microfluidic channels laminated with polyvinylidene chloride. In microtubes, concentrations of bacteria and pH in the suspension were analyzed by measuring turbidity and using an ISFET sensor, respectively. In microfluidic channels containing 20 μL of bacterial suspension, we measured pH changes using the ISFET sensor and monitored biofilm formation using a microscope. We detected acidification and alkalinization phases of M. luteus from the ISFET sensor signals in both microtubes and microfluidic channels. In the alkalinization phase, after 2 day culture, dense biofilm formation was observed at the bottom of the microfluidic channels. In this study, we used an ISFET sensor to detect biofilm formation in clinical and industrial microfluidic environments by detecting alkalinization of the culture medium. 

Signal processing for liquid ionization calorimeters

International Nuclear Information System (INIS)

Cleland, W.E.; Stern, E.G.

1992-01-01

We present the results of a study of the effects of thermal and pileup noise in liquid ionization calorimeters operating in a high luminosity calorimeters operating in a high luminosity environment. The method of optimal filtering of multiply-sampled signals which may be used to improve the timing and amplitude resolution of calorimeter signals is described, and its implications for signal shaping functions are examined. The dependence of the time and amplitude resolution on the relative strength of the pileup and thermal noise, which varies with such parameters as luminosity, rapidity and calorimeter cell size, is examined

The CaloRIC ASIC: Signal Processing for High Granularity Calorimeter

International Nuclear Information System (INIS)

Royer, L; Manen, S; Soumpholphakdy, X; Bonnard, J; Gay, P

2013-01-01

A readout ASIC called CaloRIC, has been developed to fulfil the signal processing requirements for the Silicon-Tungsten (Si-W) electromagnetic calorimeter of the International Linear Collider (ILC). This ASIC performs the complete processing of the signal delivered by the Si-PIN diode of the detector: charge sensitive amplification, shaping, analog memorization and digitization. Measurements show a global integral non-linearity better than 0.2% for low energy particles, and limited to 2% for high energy particles. The measured Equivalent Noise Charge (ENC) is evaluated at 0.6 fC, which corresponds to 1/6 times the signal released by a Minimum Ionizing Particle (MIP). With the timing sequence of the ILC, the power consumption of the complete channel is evaluated at 43 μW using a power pulsing. A new ASIC (CaloRIC 4 ch) with four improved readout channels has been designed and is ready for manufacturing.

High-Sensitivity Temperature-Independent Silicon Photonic Microfluidic Biosensors

Science.gov (United States)

Kim, Kangbaek

Optical biosensors that can precisely quantify the presence of specific molecular species in real time without the need for labeling have seen increased use in the drug discovery industry and molecular biology in general. Of the many possible optical biosensors, the TM mode Si biosensor is shown to be very attractive in the sensing application because of large field amplitude on the surface and cost effective CMOS VLSI fabrication. Noise is the most fundamental factor that limits the performance of sensors in development of high-sensitivity biosensors, and noise reduction techniques require precise studies and analysis. One such example stems from thermal fluctuations. Generally SOI biosensors are vulnerable to ambient temperature fluctuations because of large thermo-optic coefficient of silicon (˜2x10 -4 RIU/K), typically requiring another reference ring and readout sequence to compensate temperature induced noise. To address this problem, we designed sensors with a novel TM-mode shallow-ridge waveguide that provides both large surface amplitude for bulk and surface sensing. With proper design, this also provides large optical confinement in the aqueous cladding that renders the device athermal using the negative thermo-optic coefficient of water (~ --1x10-4RIU/K), demonstrating cancellation of thermo-optic effects for aqueous solution operation near 300K. Additional limitations resulting from mechanical actuator fluctuations, stability of tunable lasers, and large 1/f noise of lasers and sensor electronics can limit biosensor performance. Here we also present a simple harmonic feedback readout technique that obviates the need for spectrometers and tunable lasers. This feedback technique reduces the impact of 1/f noise to enable high-sensitivity, and a DSP lock-in with 256 kHz sampling rate can provide down to micros time scale monitoring for fast transitions in biomolecular concentration with potential for small volume and low cost. In this dissertation, a novel

Comparison of the NPL water calorimeter with other dosimetric techniques for high energy photon beams

International Nuclear Information System (INIS)

Rosser, K.E.; Williams, A.J.

1999-01-01

At present, the primary standard of absorbed dose to water at NPL in high energy photon beams is a graphite calorimeter. However the quantity of interest in radiation dosimetry is absorbed dose to water. Therefore, a new absorbed dose to water standard based on water calorimetry is being developed at NPL. The calorimeter operates at 4 deg. C, with temperature control being provided by a combination of liquid and air cooling. The sealed glass inner vessel of the calorimeter has been designed to minimise the effect of non-water materials on the measurement of absorbed dose. Measurements of absorbed dose to water made in 6, 10 and 19 MV photon beams agreed within the measurement uncertainties with those determined using the primary standard graphite calorimeter. Also the absorbed dose to water measured using the water calorimeter agrees with that based on the air kerma standards for 60 Co γ-radiation within the uncertainties. The development of the water calorimeter will lead to a very robust dosimetry system at NPL, where the absorbed dose to water can be determined using three independent techniques. (author)

AIDA: concerted calorimeter development

CERN Multimedia

Felix Sefkow

2013-01-01

AIDA – the EU-funded project bringing together more than 80 institutes worldwide – aims at developing new detector solutions for future accelerators. Among the highlights reported at AIDA’s recent annual meeting in Frascati was the completion of an impressive calorimeter test beam programme, conducted by the CALICE collaboration over the past two years at CERN’s PS and SPS beam lines.   The CALICE tungsten calorimeter prototype under test at CERN. This cubic-metre hadron calorimeter prototype has almost 500,000 individually read-out electronics channels – more than all the calorimeters of ATLAS and CMS put together. Calorimeter development in AIDA is mainly motivated by experiments at possible future electron-positron colliders, namely ILC or CLIC. The physics requirements of such future machines demand extremely high-performance calorimetry. This is best achieved using a finely segmented system that reconstructs events using the so-called pa...

Integrated Cantilever-Based Flow Sensors with Tunable Sensitivity for In-Line Monitoring of Flow Fluctuations in Microfluidic Systems

Directory of Open Access Journals (Sweden)

Nadine Noeth

2013-12-01

Full Text Available For devices such as bio-/chemical sensors in microfluidic systems, flow fluctuations result in noise in the sensor output. Here, we demonstrate in-line monitoring of flow fluctuations with a cantilever-like sensor integrated in a microfluidic channel. The cantilevers are fabricated in different materials (SU-8 and SiN and with different thicknesses. The integration of arrays of holes with different hole size and number of holes allows the modification of device sensitivity, theoretical detection limit and measurement range. For an average flow in the microliter range, the cantilever deflection is directly proportional to the flow rate fluctuations in the microfluidic channel. The SiN cantilevers show a detection limit below 1 nL/min and the thinnest SU-8 cantilevers a detection limit below 5 nL/min. Finally, the sensor is applied for in-line monitoring of flow fluctuations generated by external pumps connected to the microfluidic system.

HARP: high-pressure argon readout for calorimeters

International Nuclear Information System (INIS)

Barranco-Luque, M.; Fabjan, C.W.; Frandsen, P.K.

1982-01-01

Steel tubes of approximately 8 mm O.D., filled with Argon gas to approx. 200 bar, are considered as the active element for a charge collecting sampling calorimeter readout system. The tubes are permanently sealed and operated in the ion chamber mode, with the charge collection on a one-millimeter concentric anode. We present the motivation for such a device, including Monte Carlo predictions of performance. The method of construction and signal collection are discussed, with initial results on leakage and ageing of the filling gas. A prototype electromagnetic calorimeter is described

A high resolution electromagnetic calorimeter based on lead-tungstate crystals

Czech Academy of Sciences Publication Activity Database

Aleksandrov, D. V.; Burachas, S.F.; Ippolitov, M.S.; Mareš, Jiří A.; Polák, Karel

2005-01-01

Roč. 550, - (2005), s. 169-184 ISSN 0168-9002 Institutional research plan: CEZ:AV0Z10100521 Keywords : PbWO 3 * high resolution electromagnetic calorimeter Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.224, year: 2005

Prototype tests for a highly granular scintillator-based hadronic calorimeter

OpenAIRE

Liu, Yong; Collaboration, for the CALICE

2017-01-01

Within the CALICE collaboration, several concepts for the hadronic calorimeter of a future lepton collider detector are studied. After having demonstrated the capabilities of the measurement methods in "physics prototypes", the focus now lies on improving their implementation in "technological prototypes", that are scalable to the full linear collider detector. The Analogue Hadronic Calorimeter (AHCAL) concept is a sampling calorimeter of tungsten or steel absorber plates and plastic scintill...

Large-Area Silicon Detectors for the CMS High Granularity Calorimeter

CERN Document Server

Pree, Elias

2017-01-01

During the so-called Phase-2 Upgrade, the CMS experiment at CERN will undergo significant improvements to cope with the 10-fold luminosity increase of the High Luminosity LHC (HL-LHC) era. Especially the forward calorimetry will suffer from very high radiation levels and intensified pileup in the detectors. For this reason, the CMS collaboration is designing a High Granularity Calorimeter (HGCAL) to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The CE-E and a large fraction of CE-H will consist of a sandwich structure with silicon as active detector material. This paper presents an overview of the ongoing sensor development for the HGCAL and highlights important design features and measurement techniques. The design and layout of an 8-inch silicon sensor prototype is shown. The hexagonal sensors consist of 235 pads, each with an area of about \\mbox{1~cm$^{2}$}. Furthermore, Synopsys...

Pulsed laser triggered high speed microfluidic switch

Science.gov (United States)

Wu, Ting-Hsiang; Gao, Lanyu; Chen, Yue; Wei, Kenneth; Chiou, Pei-Yu

2008-10-01

We report a high-speed microfluidic switch capable of achieving a switching time of 10 μs. The switching mechanism is realized by exciting dynamic vapor bubbles with focused laser pulses in a microfluidic polydimethylsiloxane (PDMS) channel. The bubble expansion deforms the elastic PDMS channel wall and squeezes the adjacent sample channel to control its fluid and particle flows as captured by the time-resolved imaging system. A switching of polystyrene microspheres in a Y-shaped channel has also been demonstrated. This ultrafast laser triggered switching mechanism has the potential to advance the sorting speed of state-of-the-art microscale fluorescence activated cell sorting devices.

Towards Multiplex Molecular Diagnosis—A Review of Microfluidic Genomics Technologies

Directory of Open Access Journals (Sweden)

Ismail Hussain Kamal Basha

2017-08-01

Full Text Available Highly sensitive and specific pathogen diagnosis is essential for correct and timely treatment of infectious diseases, especially virulent strains, in people. Point-of-care pathogen diagnosis can be a tremendous help in managing disease outbreaks as well as in routine healthcare settings. Infectious pathogens can be identified with high specificity using molecular methods. A plethora of microfluidic innovations in recent years have now made it increasingly feasible to develop portable, robust, accurate, and sensitive genomic diagnostic devices for deployment at the point of care. However, improving processing time, multiplexed detection, sensitivity and limit of detection, specificity, and ease of deployment in resource-limited settings are ongoing challenges. This review outlines recent techniques in microfluidic genomic diagnosis and devices with a focus on integrating them into a lab on a chip that will lead towards the development of multiplexed point-of-care devices of high sensitivity and specificity.

Materials for Microfluidic Immunoassays: A Review.

Science.gov (United States)

Mou, Lei; Jiang, Xingyu

2017-08-01

Conventional immunoassays suffer from at least one of these following limitations: long processing time, high costs, poor user-friendliness, technical complexity, poor sensitivity and specificity. Microfluidics, a technology characterized by the engineered manipulation of fluids in channels with characteristic lengthscale of tens of micrometers, has shown considerable promise for improving immunoassays that could overcome these limitations in medical diagnostics and biology research. The combination of microfluidics and immunoassay can detect biomarkers with faster assay time, reduced volumes of reagents, lower power requirements, and higher levels of integration and automation compared to traditional approaches. This review focuses on the materials-related aspects of the recent advances in microfluidics-based immunoassays for point-of-care (POC) diagnostics of biomarkers. We compare the materials for microfluidic chips fabrication in five aspects: fabrication, integration, function, modification and cost, and describe their advantages and drawbacks. In addition, we review materials for modifying antibodies to improve the performance of the reaction of immunoassay. We also review the state of the art in microfluidic immunoassays POC platforms, from the laboratory to routine clinical practice, and also commercial products in the market. Finally, we discuss the current challenges and future developments in microfluidic immunoassays. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

CERN Document Server

Marzocchi, Badder

2017-01-01

The CMS Electromagnetic Calorimeter is made of scintillating lead tungstate crystals, using avalanche photodiodes (APD) as photo-detectors in the barrel part. The high voltage system, consisting of 1224 channels, biases groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented.

Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays.

Science.gov (United States)

Hansson, Jonas; Yasuga, Hiroki; Haraldsson, Tommy; van der Wijngaart, Wouter

2016-01-21

We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of an OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We demonstrate the distinct benefits of Synthetic Microfluidic Paper over other porous microfluidic materials, such as nitrocellulose, traditional paper and straight micropillar arrays: in contrast to straight micropillar arrays, the geometry of Synthetic Microfluidic Paper was miniaturized without suffering capillary collapse during manufacturing and fluidic operation, resulting in a six-fold increased internal surface area and a three-fold increased porous fraction. Compared to commercial nitrocellulose materials for capillary assays, Synthetic Microfluidic Paper shows a wider range of capillary pumping speed and four times lower device-to-device variation. Compared to the surfaces of the other porous microfluidic materials that are modified by adsorption, Synthetic Microfluidic Paper contains free thiol groups and has been shown to be suitable for covalent surface chemistry, demonstrated here for increasing the material hydrophilicity. These results illustrate the potential of Synthetic Microfluidic Paper as a porous microfluidic material with improved performance characteristics, especially for bioassay applications such as diagnostic tests.

Design, performance, and calibration of CMS forward calorimeter wedges

Energy Technology Data Exchange (ETDEWEB)

Abdullin, S. [Fermi National Accelerator Lab., Batavia, IL (United States)]|[Univ. of Maryland, College Park, MD (United States); Abramov, V.; Goncharov, P.; Kalinin, A.; Khmelnikov, A.; Korablev, A.; Korneev, Y.; Krinitsyn, A.; Kryshkin, V.; Lukanin, V.; Pikalov, V.; Ryazanov, A.; Talov, V.; Turchanovich, L.; Volkov, A. [IHEP, Protvino (Russian Federation); Acharya, B.; Banerjee, Sud.; Banerjee, Sun.; Chendvankar, S.; Dugad, S.; Kalmani, S.; Katta, S.; Mazumdar, K.; Mondal, N.; Nagaraj, P.; Patil, M.; Reddy, L.; Satyanarayana, B.; Sharma, S.; Verma, P. [Tata Inst. of Fundamental Research, Mumbai (India); Adams, M.; Burchesky, K.; Qiang, W. [Univ. of Illinois, Chicago, IL (United States); Akchurin, N.; Carrell, K.; Guemues, K.; Kim, H.; Spezziga, M.; Thomas, R.; Wigmans, R. [Texas Tech Univ., Dept. of Physics, Lubbock, TX (United States); Akgun, U.; Ayan, S.; Duru, F.; Merlo, J.P.; Mestvirishvili, A.; Miller, M.; Norbeck, E.; Olson, J.; Onel, Y.; Schmidt, I. [Univ. of Iowa, Iowa City, IA (United States); Anderson, E.W.; Hauptman, J. [Iowa State Univ., Ames, IA (United States); Antchev, G.; Arcidy, M.; Hazen, E.; Lawlor, C.; Machado, E.; Posch, C.; Rohlf, J.; Sulak, L.; Varela, F.; Wu, S.X. [Boston Univ., MA (United States); Aydin, S.; Bakirci, M.N.; Cerci, S.; Dumanoglu, I.; Eskut, E.; Kayis-Topaksu, A.; Koylu, S.; Kurt, P.; Kuzucu-Polatoz, A.; Onengut, G.; Ozdes-Koca, N.; Ozkurt, H.; Sogut, K.; Topakli, H.; Vergili, M.; Yetkin, T. [Cukurova Univ., Adana (Turkey); Baarmand, M.; Mermerkaya, H.; Vodopiyanov, I. [Florida Inst. of Tech., Melbourne, FL (United States); Babich, K.; Golutvin, I.; Kalagin, V.; Kosarev, I.; Ladygin, V.; Mescheryakov, G.; Moissenz, P.; Petrosyan, A.; Rogalev, E.; Smirnov, V.; Vishnevskiy, A.; Volodko, A.; Zarubin, A. [JINR, Dubna (Russian Federation); Baden, D.; Bard, R.; Eno, S.; Grassi, T.; Jarvis, C.; Kellogg, R.; Kunori, S.; Skuja, A.; Wang, L.; Wetstein, M. [Univ. of Maryland, College Park, MD (United States)] [and others

2008-01-15

We report on the test beam results and calibration methods using high energy electrons, pions and muons with the CMS forward calorimeter (HF). The HF calorimeter covers a large pseudorapidity region (3{<=} vertical stroke {eta} vertical stroke {<=}5), and is essential for a large number of physics channels with missing transverse energy. It is also expected to play a prominent role in the measurement of forward tagging jets in weak boson fusion channels in Higgs production. The HF calorimeter is based on steel absorber with embedded fused-silica-core optical fibers where Cherenkov radiation forms the basis of signal generation. Thus, the detector is essentially sensitive only to the electromagnetic shower core and is highly non-compensating (e/h{approx}5). This feature is also manifest in narrow and relatively short showers compared to similar calorimeters based on ionization. The choice of fused-silica optical fibers as active material is dictated by its exceptional radiation hardness. The electromagnetic energy resolution is dominated by photoelectron statistics and can be expressed in the customary form as (a)/({radical}(E))+b. The stochastic term a is 198% and the constant term b is 9%. The hadronic energy resolution is largely determined by the fluctuations in the neutral pion production in showers, and when it is expressed as in the electromagnetic case, a=280% and b=11%. (orig.)

A low-power high dynamic range front-end ASIC for imaging calorimeters

CERN Document Server

Bagliesi, M G; Marrocchesi, P S; Meucci, M; Millucci, V; Morsani, F; Paoletti, R; Pilo, F; Scribano, A; Turini, N; Valle, G D

2002-01-01

High granularity calorimeters with shower imaging capabilities require dedicated front-end electronics. The ICON 4CH and VA4 PMT chip-set is suitable for very high dynamic range systems with strict noise requirements. The ICON 4CH is a 4 channel input, 12 channel output ASIC designed for use in a multi-anode photomultiplier system with very large dynamic range and low-noise requirements. Each of the four input signals to the ASIC is split equally into three branches by a current conveyor. Each of the three branches is scaled differently: 1:1, 1:8 and 1:80. The signal is read out by a 12 channel low noise/low power high dynamic range charge sensitive preamplifier-shaper circuit (VA4-PMT chip), with simultaneous sample- and-hold, multiplexed analog read-out, calibration facilities. Tests performed in our lab with a PMT are reported in terms of linearity, dynamic range and cross-talk of the system. (5 refs).

Monitoring light source for CMS lead tungstate crystal calorimeter at LHC

CERN Document Server

Zhang Liang Ying; Zhu, R Y; Liu, D T

2001-01-01

Light monitoring will serve as an intercalibration for Compact Muon Solenoid (CMS) lead tungstate crystals in situ at the Large Hadronic Collider, which is crucial for maintaining crystal calorimeter's subpercent constant term in the energy resolution. This paper presents the design of the CMS electromagnetic calorimeter monitoring light source and high-level distribution system. The correlations between variations of the light output and the transmittance for the CMS choice of yttrium-doped PbWO/sub 4/ crystals were investigated and were used to study monitoring linearity and sensitivity as a function of wavelength. The monitoring wavelength was determined so that a good linearity as well as adequate sensitivity can be achieved. The performance of a custom manufactured tunable laser system is presented. Issues related to monitoring precision are discussed. (12 refs).

Recent developments in crystal calorimeters (featuring the CMS PbWO4 electromagnetic calorimeter)

International Nuclear Information System (INIS)

Gascon-Shotkin, S.

2003-01-01

In the mass range of 110-150 GeV the favored process for Higgs boson detection via p-p collisions is via its decay into two photons, which demands a very high-resolution electromagnetic calorimeter. This physics goal plus the Large Hadron Calorimeter (LHC)-imposed design constraints of 25ns bunch spacing and a hostile radiation environment have led the Compact Muon Solenoid (CMS) collaboration to the choice of lead tungstate (PbWO 4 ) crystals. These factors plus the presence of a 4T magnetic field and the relatively low room-temperature scintillation photon yield of PbWO 4 make photo detection a real challenge, which CMS has met via the choice of devices providing gain amplification: Avalanche photodiodes (APD) in the central barrel region and vacuum phototriodes (VPT) in the forward and backward endcap regions. In the past year the CMS electromagnetic calorimeter has entered the construction phase. We review progress in the areas of crystals, barrel and endcap photo detection devices, plans for detector calibration as well as the status of assembly and quality control. We also invoke relevant developments in other crystal calorimeters currently in operation or under development. Crystal calorimeters remain the medium of choice for precision energy and position measurements in high energy physics

Undergraduate Laboratory Module for Implementing ELISA on the High Performance Microfluidic Platform

Science.gov (United States)

Giri, Basant; Peesara, Ravichander R.; Yanagisawa, Naoki; Dutta, Debashis

2015-01-01

Implementing enzyme-linked immunosorbent assays (ELISA) in microchannels offers several advantages over its traditional microtiter plate-based format, including a reduced sample volume requirement, shorter incubation period, and greater sensitivity. Moreover, microfluidic ELISA platforms are inexpensive to fabricate and allow integration of…

Measuring the short-term substrate utilization response to high-carbohydrate and high-fat meals in the whole-body indirect calorimeter.

Science.gov (United States)

Gribok, Andrei; Leger, Jayme L; Stevens, Michelle; Hoyt, Reed; Buller, Mark; Rumpler, William

2016-06-01

The paper demonstrates that minute-to-minute metabolic response to meals with different macronutrient content can be measured and discerned in the whole-body indirect calorimeter. The ability to discriminate between high-carbohydrate and high-fat meals is achieved by applying a modified regularization technique with additional constraints imposed on oxygen consumption rate. These additional constraints reduce the differences in accuracy between the oxygen and carbon dioxide analyzers. The modified technique was applied to 63 calorimeter sessions that were each 24 h long. The data were collected from 16 healthy volunteers (eight males, eight females, aged 22-35 years). Each volunteer performed four 24-h long calorimeter sessions. At each session, they received one of four treatment combinations involving exercise (high or low intensity) and diet (a high-fat or high-carbohydrate shake for lunch). One volunteer did not complete all four assignments, which brought the total number of sessions to 63 instead of 64. During the 24-h stay in the calorimeter, subjects wore a continuous glucose monitoring system, which was used as a benchmark for subject's postprandial glycemic response. The minute-by-minute respiratory exchange ratio (RER) data showed excellent agreement with concurrent subcutaneous glucose concentrations in postprandial state. The averaged minute-to-minute RER response to the high-carbohydrate shake was significantly different from the response to high-fat shake. Also, postprandial RER slopes were significantly different for two dietary treatments. The results show that whole-body respiration calorimeters can be utilized as tools to study short-term kinetics of substrate oxidation in humans. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Mechanical construction and installation of the ATLAS tile calorimeter

Energy Technology Data Exchange (ETDEWEB)

Abdallah, J [IFIC, Centro Mixto Universidad de Valencia-CSIC, E46100 Burjassot, Valencia (Spain); Adragna, P; Bosi, F [Pisa University and INFN, Pisa (Italy); Alexa, C; Boldea, V [Institute of Atomic Physics, Bucharest (Romania); Alves, R [LIP and FCTUC University of Coimbra (Portugal); Amaral, P; Andresen, X; Behrens, A; Blocki, J [CERN, Geneva (Switzerland); Ananiev, A [LIP and IDMEC-IST, Lisbon (Portugal); Anderson, K [University of Chicago, Chicago, Illinois (United States); Antonaki, A [University of Athens, Athens (Greece); Batusov, V [JINR, Dubna (Russian Federation); Bednar, P [Comenius University, Bratislava (Slovakia); Bergeaas, E; Bohm, C [Stockholm University, Stockholm (Sweden); Biscarat, C [LPC Clermont-Ferrand, Université Blaise Pascal, Clermont-Ferrand (France); Blanch, O; Blanchot, G [Institut de Fisica d' Altes Energies, Universitat Autònoma de Barcelona, Barcelona (Spain); others, and

2013-11-01

This paper summarises the mechanical construction and installation of the Tile Calorimeter for the ATLAS experiment at the Large Hadron Collider in CERN, Switzerland. The Tile Calorimeter is a sampling calorimeter using scintillator as the sensitive detector and steel as the absorber and covers the central region of the ATLAS experiment up to pseudorapidities ±1.7. The mechanical construction of the Tile Calorimeter occurred over a period of about 10 years beginning in 1995 with the completion of the Technical Design Report and ending in 2006 with the installation of the final module in the ATLAS cavern. During this period approximately 2600 metric tons of steel were transformed into a laminated structure to form the absorber of the sampling calorimeter. Following instrumentation and testing, which is described elsewhere, the modules were installed in the ATLAS cavern with a remarkable accuracy for a structure of this size and weight.

Mechanical construction and installation of the ATLAS tile calorimeter

International Nuclear Information System (INIS)

Abdallah, J; Adragna, P; Bosi, F; Alexa, C; Boldea, V; Alves, R; Amaral, P; Andresen, X; Behrens, A; Blocki, J; Ananiev, A; Anderson, K; Antonaki, A; Batusov, V; Bednar, P; Bergeaas, E; Bohm, C; Biscarat, C; Blanch, O; Blanchot, G

2013-01-01

This paper summarises the mechanical construction and installation of the Tile Calorimeter for the ATLAS experiment at the Large Hadron Collider in CERN, Switzerland. The Tile Calorimeter is a sampling calorimeter using scintillator as the sensitive detector and steel as the absorber and covers the central region of the ATLAS experiment up to pseudorapidities ±1.7. The mechanical construction of the Tile Calorimeter occurred over a period of about 10 years beginning in 1995 with the completion of the Technical Design Report and ending in 2006 with the installation of the final module in the ATLAS cavern. During this period approximately 2600 metric tons of steel were transformed into a laminated structure to form the absorber of the sampling calorimeter. Following instrumentation and testing, which is described elsewhere, the modules were installed in the ATLAS cavern with a remarkable accuracy for a structure of this size and weight

Low-energetic hadron interactions in a highly granular calorimeter

International Nuclear Information System (INIS)

Feege, Nils

2011-12-01

The CALICE collaboration develops imaging calorimeters for precision measurements at a future electron-positron linear collider. These calorimeters feature a fine granularity in both longitudinal and transverse direction, which is needed to fulfill the shower separation requirement of Particle Flow reconstruction algorithms. CALICE has constructed prototypes for several design options for electromagnetic and hadron calorimeters and has successfully operated these detectors during combined test-beam programs at DESY, CERN, and Fermilab since 2005. The focus of this dissertation is on the prototype for a hadron calorimeter with analog readout (AHCAL), which is a 1m 3 scintillator-steel sampling calorimeter with 38 sensitive layers and a depth of 5.3 nuclear interaction lengths. Each scintillator layer is pieced together from separate tiles with embedded silicon photomultipliers (SiPMs) for measuring the scintillation light. With a total of 7608 readout channels, the AHCAL prototype represents the first large-scale application of SiPMs. This thesis covers the commissioning and operation of the AHCAL and other detectors for several months at the Fermilab Test-beam Facility in 2008 and 2009 and the analysis of electron and pion data collected during these measurements. The analysis covers energies from 1 GeV to 30 GeV and is the first analysis of AHCAL data at energies below 8 GeV. Because the purity of the recorded data is not sufficient for analysis, event selection procedures for electrons and pions at these energies and a method to estimate the purities of these data samples are developed. The calibration of detectors employing SiPMs requires parameters that change with operating voltage and temperature. The correction of these parameters for the effects of temperature variations during data collection and their portability to different operating conditions are evaluated using the AHCAL as an example. This is important for the use of this technology in a collider

Low-energetic hadron interactions in a highly granular calorimeter

Energy Technology Data Exchange (ETDEWEB)

Feege, Nils

2011-12-15

The CALICE collaboration develops imaging calorimeters for precision measurements at a future electron-positron linear collider. These calorimeters feature a fine granularity in both longitudinal and transverse direction, which is needed to fulfill the shower separation requirement of Particle Flow reconstruction algorithms. CALICE has constructed prototypes for several design options for electromagnetic and hadron calorimeters and has successfully operated these detectors during combined test-beam programs at DESY, CERN, and Fermilab since 2005. The focus of this dissertation is on the prototype for a hadron calorimeter with analog readout (AHCAL), which is a 1m{sup 3} scintillator-steel sampling calorimeter with 38 sensitive layers and a depth of 5.3 nuclear interaction lengths. Each scintillator layer is pieced together from separate tiles with embedded silicon photomultipliers (SiPMs) for measuring the scintillation light. With a total of 7608 readout channels, the AHCAL prototype represents the first large-scale application of SiPMs. This thesis covers the commissioning and operation of the AHCAL and other detectors for several months at the Fermilab Test-beam Facility in 2008 and 2009 and the analysis of electron and pion data collected during these measurements. The analysis covers energies from 1 GeV to 30 GeV and is the first analysis of AHCAL data at energies below 8 GeV. Because the purity of the recorded data is not sufficient for analysis, event selection procedures for electrons and pions at these energies and a method to estimate the purities of these data samples are developed. The calibration of detectors employing SiPMs requires parameters that change with operating voltage and temperature. The correction of these parameters for the effects of temperature variations during data collection and their portability to different operating conditions are evaluated using the AHCAL as an example. This is important for the use of this technology in a

Testing hadronic interaction models using a highly granular silicon-tungsten calorimeter

Czech Academy of Sciences Publication Activity Database

Bilki, B.; Repond, J.; Schlereth, J.; Cvach, Jaroslav; Gallus, Petr; Havránek, Miroslav; Janata, Milan; Kvasnička, Jiří; Lednický, Richard; Marčišovský, Michal; Polák, Ivo; Popule, Jiří; Tomášek, Lukáš; Tomášek, Michal; Růžička, Pavel; Šícho, Petr; Smolík, Jan; Vrba, Václav; Zálešák, Jaroslav

2015-01-01

Roč. 794, Sep (2015), s. 240-254 ISSN 0168-9002 R&D Projects: GA MŠk LG14033 Institutional support: RVO:68378271 Keywords : electromagnetic silicon tungsten calorimeter * highly granular detectors * hadronic showers * data and simulations Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.200, year: 2015

Experimental and simulation study of irradiated silicon pad detectors for the CMS High Granularity Calorimeter

CERN Document Server

Peltola, Timo Hannu Tapani

2017-01-01

The foreseen upgrade of the LHC to its high luminosity phase (HL-LHC), will maximize the physics potential of the facility. The upgrade is expected to increase the instantaneous luminosity by a factor of 5 and deliver an integrated luminosity of 3000 fb$^{-1}$ after 10 years of operation. As a result of the corresponding increase in radiation and pileup, the electromagnetic calorimetry in the CMS endcaps will sustain maximum integrated doses of 1.5 MGy and neutron fluences above 10$^{16}$ n$_{\\mathrm{eq}}$/cm$^2$, necessitating their replacement for HL-LHC operation. The CMS collaboration has decided to replace the existing endcap electromagnetic and hadronic calorimeters by a High Granularity Calorimeter (HGCAL) that will provide unprecedented information on electromagnetic and hadronic showers in the very high pileup of the HL-LHC. The HGCAL will be realized as a sampling calorimeter with 52 layers of active material. The electromagnetic section and the high-radiation region of the hadronic section will use...

A neutron calorimeter as a fusion diagnostic

International Nuclear Information System (INIS)

Proctor, A.E.; Harker, Y.D.; Neischmidt, E.B.

1986-01-01

A calorimeter is described which is applicable as a fusion neutron diagnostic. The advantages of the device are discussed, including: low sensitivity to thermal neutrons, no heat loss to surroundings, large dynamic range, small mass resulting in fair time resolution, and small physical size. The heat generation is provided by neutron induced fissions in a foil of 238 U and a calorimeter is isothermal. The effects, advantages and disadvantages of other target materials are discussed. Also discussed are time resolution and calibration

Radiation hardness and precision timing study of Silicon Detectors for the CMS High Granularity Calorimeter (HGCAL)

CERN Document Server

Curras Rivera, Esteban

2016-01-01

The high luminosity LHC (HL-LHC or Phase-II) is expected to increase the instantaneous luminosity of the LHC by a factor of about five, delivering about 250 fba-1 per year between 2025 and 2035. Under these conditions the performance degradation of detectors due to integrated radiation dose/fluence will need to be addressed. The CMS collaboration is planning to upgrade many components, including the forward calorimeters. The replacement for the existing endcap preshower, electromagnetic and hadronic calorimeters is called the High Granularity Calorimeter (HGCAL) and it will be realized as a sampling calorimeter, including 30 layers of silicon detectors totalling 600m^2. The sensors will be realized as pad detectors with cell sizes of between 0.5-1.0 cm^2 and an active thickness between 100 um and 300 um depending on their location in the endcaps the thinner sensors will be used in the highest radiation environment. For an integrated luminosity of 3000 fba-1, the electromagnetic calorimetry will sustain integ...

Microfluidic Devices for Drug Delivery Systems and Drug Screening

Science.gov (United States)

Kompella, Uday B.; Damiati, Safa A.

2018-01-01

Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system. PMID:29462948

Electronics and triggering challenges for the CMS High Granularity Calorimeter

Science.gov (United States)

Lobanov, A.

2018-02-01

The High Granularity Calorimeter (HGCAL), presently being designed by the CMS collaboration to replace the CMS endcap calorimeters for the High Luminosity phase of LHC, will feature six million channels distributed over 52 longitudinal layers. The requirements for the front-end electronics are extremely challenging, including high dynamic range (0.2 fC-10 pC), low noise (~2000 e- to be able to calibrate on single minimum ionising particles throughout the detector lifetime) and low power consumption (~20 mW/channel), as well as the need to select and transmit trigger information with a high granularity. Exploiting the intrinsic precision-timing capabilities of silicon sensors also requires careful design of the front-end electronics as well as the whole system, particularly clock distribution. The harsh radiation environment and requirement to keep the whole detector as dense as possible will require novel solutions to the on-detector electronics layout. Processing the data from the HGCAL imposes equally large challenges on the off-detector electronics, both for the hardware and incorporated algorithms. We present an overview of the complete electronics architecture, as well as the performance of prototype components and algorithms.

Upgrade of the ATLAS hadronic Tile calorimeter for the High luminosity LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00236332; The ATLAS collaboration

2016-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS detector at the LHC. It is a sampling calorimeter consisting of alternating thin steel plates and scintillating tiles. Wavelength shifting fibers coupled to the tiles collect the produced light and are read out by photomultiplier tubes. An analog sum of the processed signal of several photomultipliers serves as input to the first level of trigger. Photomultiplier signals are then digitized and stored on detector and are only transferred off detector once the first trigger acceptance has been confirmed. The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade, in 2024, will accommodate the detector and data acquisition system for the HL-LHC. In particular, TileCal will undergo a major replacement of its on- and off-detector electronics. All signals will be digitized and then...

Upgrade of the ATLAS hadronic Tile calorimeter for the High luminosity LHC

CERN Document Server

Mlynarikova, Michaela; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS detector at the LHC. It is a sampling calorimeter consisting of alternating thin steel plates and scintillating tiles. Wavelength shifting fibers coupled to the tiles collect the produced light and are read out by photomultiplier tubes. Currently, an analog sum of the processed signal of several photomultipliers serves as input to the first level of trigger. Photomultiplier signals are then digitized and stored on detector and are only transferred off detector once the first trigger acceptance has been confirmed. The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade, in 2024, will accommodate the detector and data acquisition system for the HL-LHC. In particular, TileCal will undergo a major replacement of its on- and off-detector electronics. All signals will be digitiz...

Thin film metal sensors in fusion bonded glass chips for high-pressure microfluidics

International Nuclear Information System (INIS)

Andersson, Martin; Ek, Johan; Hedman, Ludvig; Johansson, Fredrik; Sehlstedt, Viktor; Stocklassa, Jesper; Snögren, Pär; Pettersson, Victor; Larsson, Jonas; Vizuete, Olivier; Hjort, Klas; Klintberg, Lena

2017-01-01

High-pressure microfluidics offers fast analyses of thermodynamic parameters for compressed process solvents. However, microfluidic platforms handling highly compressible supercritical CO 2 are difficult to control, and on-chip sensing would offer added control of the devices. Therefore, there is a need to integrate sensors into highly pressure tolerant glass chips. In this paper, thin film Pt sensors were embedded in shallow etched trenches in a glass wafer that was bonded with another glass wafer having microfluidic channels. The devices having sensors integrated into the flow channels sustained pressures up to 220 bar, typical for the operation of supercritical CO 2 . No leakage from the devices could be found. Integrated temperature sensors were capable of measuring local decompression cooling effects and integrated calorimetric sensors measured flow velocities over the range 0.5–13.8 mm s −1 . By this, a better control of high-pressure microfluidic platforms has been achieved. (paper)

X-ray calorimeters used for measurement in laser-fusion experiments

International Nuclear Information System (INIS)

Tang Daorun; China Academy of Engineering Physics, Mianyang; Wu Dengxue; Lin Libin; Sun Kexu; Jiang Shaoen

2005-01-01

X-ray calorimeters are ready to measure the total soft X-ray energy emitted from the plasma produced by laser because of their bodily absorption, linear response, insensitivity to the electromagnetic disturbance, and so on. The calorimeters mainly include absorbers, thermocouples, bases and shrouds. When X-rays are deposited in the absorbers, photon energy absorbed is quickly converted into intrinsic energy which simultaneously dissipates by thermal conduction and radiation. The X-ray calorimeters were absolutely on-line calibrated in Shenguang-II laser facility with the X-ray diode array spectrometer which has been absolutely calibrated on Beijing Synchrotron Radiation Facility. 20 shots' experimental results show that the X-ray calorimeters are stable, the sensitivity of calorimeter is (84.1 ± 3.4) μv/mJ and the related combined standard uncertainty in the X-ray energy measure is about 31%. The calorimeters can be applied to measure the X-ray energy. (authors)

Thermal detection of X-rays. [cryogenic calorimeters for astronomy

Science.gov (United States)

Mccammon, D.; Edwards, B.; Juda, M.; Plucinsky, P.; Zhang, J.; Kelley, R.; Holt, S.; Madejski, G.; Moseley, S.; Szymkowiak, A.

1990-01-01

The development of calorimeters is described in terms of their proposed application to sounding-rocket investigations of cosmic X-ray sources. The fundamental theory of the energy resolution of the devices is given, and general discussions are presented regarding the limitations associated with the materials used and available thermometer types. Also given are data describing electrical nonlinearity as a function of temperature, thermistor sensitivity, and heat capacity, as well as data regarding the excess noise that aids in the conduction process. Cryogenic calorimeters based on doped semiconductor thermistors are found to be limited, although thermal detectors have important applications to high-resolution laboratory spectroscopy. Electrical nonlinearity and the excess noise are found to be important for obtaining optimum heat capacity in the thermistor.

The Time Structure of Hadronic Showers in Highly Granular Calorimeters with Tungsten and Steel Absorbers

CERN Document Server

Adloff, C.; Chefdeville, M.; Drancourt, C.; Gaglione, R.; Geffroy, N.; Karyotakis, Y.; Koletsou, I.; Prast, J.; Vouters, G.; Repond, J.; Schlereth, J.; Xia, L.; Baldolemar, E.; Li, J.; Park, S.T.; Sosebee, M.; White, A.P.; Yu, J.; Eigen, G.; Thomson, M.A.; Ward, D.R.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Apostolakis, J.; Arfaoui, A.; Benoit, M.; Dannheim, D.; Elsener, K.; Folger, G.; Grefe, C.; Ivantchenko, V.; Killenberg, M.; Klempt, W.; van der Kraaij, E.; Linssen, L.; Lucaci-Timoce, A.-I.; Münnich, A.; Poss, S.; Ribon, A.; Roloff, P.; Sailer, A.; Schlatter, D.; Sicking, E.; Strube, J.; Uzhinskiy, V.; Carloganu, C.; Gay, P.; Manen, S.; Royer, L.; Cornett, U.; David, D.; Ebrahimi, A.; Falley, G.; Feege, N.; Gadow, K.; Göttlicher, P.; Günter, C.; Hartbrich, O.; Hermberg, B.; Karstensen, S.; Krivan, F.; Krüger, K.; Lu, S.; Lutz, B.; Morozov, S.; Morgunov, V.; Neubüser, C.; Reinecke, M.; Sefkow, F.; Smirnov, P.; Terwort, M.; Fagot, A.; Tytgat, M.; Zaganidis, N.; Hostachy, J.-Y.; Morin, L.; Garutti, E.; Laurien, S.; Marchesini, I.; Matysek, M.; Ramilli, M.; Briggl, K.; Eckert, P.; Harion, T.; Schultz-Coulon, H.-Ch.; Shen, W.; Stamen, R.; Chang, S.; Khan, A.; Kim, D.H.; Kong, D.J.; Oh, Y.D.; Bilki, B.; Norbeck, E.; Northacker, D.; Onel, Y.; Wilson, G.W.; Kawagoe, K.; Miyazaki, Y.; Sudo, Y.; Ueno, H.; Yoshioka, T.; Dauncey, P.D.; Cortina Gil, E.; Mannai, S.; Baulieu, G.; Calabria, P.; Caponetto, L.; Combaret, C.; Della Negra, R.; Ete, R.; Grenier, G.; Han, R.; Ianigro, J-C.; Kieffer, R.; Laktineh, I.; Lumb, N.; Mathez, H.; Mirabito, L.; Petrukhin, A.; Steen, A.; Tromeur, W.; Vander Donckt, M.; Zoccarato, Y.; Berenguer Antequera, J.; Calvo Alamillo, E.; Fouz, M.-C.; Puerta-Pelayo, J.; Corriveau, F.; Bobchenko, B.; Chadeeva, M.; Danilov, M.; Epifantsev, A.; Markin, O.; Mizuk, R.; Novikov, E.; Rusinov, V.; Tarkovsky, E.; Kozlov, V.; Soloviev, Y.; Besson, D.; Buzhan, P.; Ilyin, A.; Kantserov, V.; Kaplin, V.; Popova, E.; Tikhomirov, V.; Gabriel, M.; Kiesling, C.; Seidel, K.; Simon, F.; Soldner, C.; Szalay, M.; Tesar, M.; Weuste, L.; Amjad, M.S.; Bonis, J.; Conforti di Lorenzo, S.; Cornebise, P.; Fleury, J.; Frisson, T.; van der Kolk, N.; Richard, F.; Pöschl, R.; Rouene, J.; Anduze, M.; Balagura, V.; Becheva, E.; Boudry, V.; Brient, J-C.; Cornat, R.; Frotin, M.; Gastaldi, F.; Guliyev, E.; Haddad, Y.; Magniette, F.; Ruan, M.; Tran, T.H.; Videau, H.; Callier, S.; Dulucq, F.; Martin-Chassard, G.; de la Taille, Ch.; Raux, L.; Seguin-Moreau, N.; Zacek, J.; Cvach, J.; Gallus, P.; Havranek, M.; Janata, M.; Kvasnicka, J.; Lednicky, D.; Marcisovsky, M.; Polak, I.; Popule, J.; Tomasek, L.; Tomasek, M.; Ruzicka, P.; Sicho, P.; Smolik, J.; Vrba, V.; Zalesak, J.; Belhorma, B.; Ghazlane, H.; Kotera, K.; Ono, H.; Takeshita, T.; Uozumi, S.; Chai, J.S.; Song, H.S.; Lee, S.H.; Götze, M.; Sauer, J.; Weber, S.; Zeitnitz, C.

2014-01-01

The intrinsic time structure of hadronic showers influences the timing capability and the required integration time of hadronic calorimeters in particle physics experiments, and depends on the active medium and on the absorber of the calorimeter. With the CALICE T3B experiment, a setup of 15 small plastic scintillator tiles read out with Silicon Photomultipliers, the time structure of showers is measured on a statistical basis with high spatial and temporal resolution in sampling calorimeters with tungsten and steel absorbers. The results are compared to GEANT4 (version 9.4 patch 03) simulations with different hadronic physics models. These comparisons demonstrate the importance of using high precision treatment of low-energy neutrons for tungsten absorbers, while an overall good agreement between data and simulations for all considered models is observed for steel.

Challenges of particle flow reconstruction in the CMS High-Granularity Calorimeter at the High-Luminosity LHC

CERN Document Server

Chlebana, Frank

2016-01-01

The challenges of the High-Luminosity LHC (HL-LHC) are driven by the large number of overlapping proton-proton collisions (pileup) in each bunch-crossing and the extreme radiation dose to detectors positioned at high pseudorapidity. To overcome this challenge CMS is designing and implementing an endcap electromagnetic+hadronic sampling calorimeter employing silicon pad devices in the electromagnetic and front hadronic sections, comprising over 6 million channels, and highly-segmented plastic scintillators in the rear part of the hadronic section. This High-Granularity Calorimeter (HGCAL) will be the first of its kind used in a colliding beam experiment. Clustering deposits of energy over many cells and layers is a complex and challenging computational task, particularly in the high-pileup and high-event-rate environment of HL-LHC. These challenges and their solutions will be discussed in detail, as well as their implementation in the HGCAL offline reconstruction. Baseline detector performance results will be ...

High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

CERN Document Server

Fasanella, Giuseppe

2017-01-01

The CMS Electromagnetic Calorimeter utilizes scintillating lead tungstate crystals, with avalanche photodiodes (APD) as photo-detectors in the barrel part. 1224 HV channels bias groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented.

High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

CERN Document Server

Fasanella, Giuseppe

2016-01-01

The CMS Electromagnetic Calorimeter utilizes scintillating lead tungstate crystals, with avalanche photodiodes (APD) as photo-detectors in the barrel part. 1224 HV channels bias groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented.

Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling

Science.gov (United States)

Shang, Yuqin; Zeng, Yun; Zeng, Yong

2016-02-01

Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges in analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and speed of lectin microarray. Moreover, we established an on-chip lectin assay which employs a very simple blocking method to effectively suppress the undesired background due to lectin binding of antibodies. Using this technology, we demonstrated focused differential profiling of tissue-specific glycosylation changes of a biomarker, CA125 protein purified from ovarian cancer cell line and different tissues from ovarian cancer patients in a fast, reproducible, and high-throughput fashion. Highly sensitive CA125 detection was also demonstrated with a detection limit much lower than the clinical cutoff value for cancer diagnosis. This microfluidic platform holds the potential to integrate with sample preparation functions to construct a fully integrated “sample-to-answer” microsystem for focused differential glycomic analysis. Thus, our technology should present a powerful tool in support of rapid advance in glycobiology and glyco-biomarker development.

Performance of the ATLAS Tile Calorimeter

CERN Document Server

Heelan, Louise; The ATLAS collaboration

2015-01-01

The ATLAS Tile hadronic calorimeter (TileCal) provides highly-segmented energy measurements of incoming particles. It is a key detector for the measurement of hadrons, jets, tau leptons and missing transverse energy. It is also useful for identification and reconstruction of muons due to good signal to noise ratio. The calorimeter consists of thin steel plates and 460,000 scintillating tiles configured into 5000 cells, each viewed by two photomultipliers. The calorimeter response and its readout electronics is monitored to better than 1% using radioactive source, laser and charge injection systems. The calibration and performance of the calorimeter have been established through test beam measurements, cosmic ray muons and the large sample of proton-proton collisions acquired in 2011 and 2012. Results on the calorimeter performance are presented, including the absolute energy scale, timing, noise and associated stabilities. The results demonstrate that the Tile Calorimeter has performed well within the design ...

Review of Recent Metamaterial Microfluidic Sensors.

Science.gov (United States)

Salim, Ahmed; Lim, Sungjoon

2018-01-15

Metamaterial elements/arrays exhibit a sensitive response to fluids yet with a small footprint, therefore, they have been an attractive choice to realize various sensing devices when integrated with microfluidic technology. Micro-channels made from inexpensive biocompatible materials avoid any contamination from environment and require only microliter-nanoliter sample for sensing. Simple design, easy fabrication process, light weight prototype, and instant measurements are advantages as compared to conventional (optical, electrochemical and biological) sensing systems. Inkjet-printed flexible sensors find their utilization in rapidly growing wearable electronics and health-monitoring flexible devices. Adequate sensitivity and repeatability of these low profile microfluidic sensors make them a potential candidate for point-of-care testing which novice patients can use reliably. Aside from degraded sensitivity and lack of selectivity in all practical microwave chemical sensors, they require an instrument, such as vector network analyzer for measurements and not readily available as a self-sustained portable sensor. This review article presents state-of-the-art metamaterial inspired microfluidic bio/chemical sensors (passive devices ranging from gigahertz to terahertz range) with an emphasis on metamaterial sensing circuit and microfluidic detection. We also highlight challenges and strategies to cope these issues which set future directions.

The CMS crystal calorimeter

CERN Document Server

Lustermann, W

2004-01-01

The measurement of the energy of electrons and photons with very high accuracy is of primary importance far the study of many physics processes at the Large Hadron Collider (LHC), in particular for the search of the Higgs Boson. The CMS experiment will use a crystal calorimeter with pointing geometry, almost covering 4p, as it offers a very good energy resolution. It is divided into a barrel composed of 61200 lead tungstate crystals, two end-caps with 14648 crystals and a pre-shower detector in front of the end-cap. The challenges of the calorimeter design arise from the high radiation environment, the 4 Tesla magnetic eld, the high bunch crossing rate of 40 MHz and the large dynamic range, requiring the development of fast, radiation hard crystals, photo-detectors and readout electronics. An overview of the construction and design of the calorimeter will be presented, with emphasis on some of the details required to meet the demanding performance goals. 19 Refs.

Scintillating plate calorimeter optical design

International Nuclear Information System (INIS)

McNeil, R.; Fazely, A.; Gunasingha, R.; Imlay, R.; Lim, J.

1990-01-01

A major technical challenge facing the builder of a general purpose detector for the SSC is to achieve an optimum design for the calorimeter. Because of its fast response and good energy resolution, scintillating plate sampling calorimeters should be considered as a possible technology option. The work of the Scintillating Plate Calorimeter Collaboration is focused on compensating plate calorimeters. Based on experimental and simulation studies, it is expected that a sampling calorimeter with alternating layers of high-Z absorber (Pb, W, DU, etc.) and plastic scintillator can be made compensating (e/h = 1.00) by suitable choice of the ratio of absorber/scintillator thickness. Two conceptual designs have been pursued by this subsystem collaboration. One is based on lead as the absorber, with read/out of the scintillator plates via wavelength shifter fibers. The other design is based on depleted uranium as the absorber with wavelength shifter (WLS) plate readout. Progress on designs for the optical readout of a compensating scintillator plate calorimeter are presented. These designs include readout of the scintillator plates via wavelength shifter plates or fiber readout. Results from radiation damage studies of the optical components are presented

LHCb Calorimeter modules arrive at CERN

CERN Multimedia

2002-01-01

Two of the three components of the LHCb Calorimeter system have started to arrive from Russia. Members of the LHCb Calorimeter group with the ECAL and HCAL modules that have just arrived at CERN. The first two of the 56 Hadron Calorimeter (HCAL) modules and 1200 of the 3300 modules of the Electromagnetic Calorimeter (ECAL) have reached CERN from Russia. The third part of the system, the Preshower detector, is still being prepared in Russia. The calorimeter system identifies and triggers on high-energy particles, namely electrons, hadrons and photons by measuring their positions and energies. The HCAL is going to be a pure trigger device. The ECAL will also be used in the triggering, but in addition it will reconstruct neutral pions and photons from B meson decays. One of the major aims of the LHCb experiment is to study CP violation through B meson decays including Bs mesons with high statistics in different decay modes. CP violation (violation of charge and parity) is necessary to explain why the Universe...

High Resolution, Non-Dispersive X-Ray Calorimeter Spectrometers on EBITs and Orbiting Observatories

Science.gov (United States)

Porter, Frederick S.

2010-01-01

X-ray spectroscopy is the primary tool for performing atomic physics with Electron beam ion trap (EBITs). X-ray instruments have generally fallen into two general categories, 1) dispersive instruments with very high spectral resolving powers but limited spectral range, limited count rates, and require an entrance slit, generally, for EBITs, defined by the electron beam itself, and 2) non-dispersive solid-state detectors with much lower spectral resolving powers but that have a broad dynamic range, high count rate ability and do not require a slit. Both of these approaches have compromises that limit the type and efficiency of measurements that can be performed. In 1984 NASA initiated a program to produce a non-dispersive instrument with high spectral resolving power for x-ray astrophysics based on the cryogenic x-ray calorimeter. This program produced the XRS non-dispersive spectrometers on the Astro-E, Astro-E2 (Suzaku) orbiting observatories, the SXS instrument on the Astro-H observatory, and the planned XMS instrument on the International X-ray Observatory. Complimenting these spaceflight programs, a permanent high-resolution x-ray calorimeter spectrometer, the XRS/EBIT, was installed on the LLNL EBIT in 2000. This unique instrument was upgraded to a spectral resolving power of 1000 at 6 keV in 2003 and replaced by a nearly autonomous production-class spectrometer, the EBIT Calorimeter Spectrometer (ECS), in 2007. The ECS spectrometer has a simultaneous bandpass from 0.07 to over 100 keV with a spectral resolving power of 1300 at 6 keV with unit quantum efficiency, and 1900 at 60 keV with a quantum efficiency of 30%. X-ray calorimeters are event based, single photon spectrometers with event time tagging to better than 10 us. We are currently developing a follow-on instrument based on a newer generation of x-ray calorimeters with a spectral resolving power of 3000 at 6 keV, and improved timing and measurement cadence. The unique capabilities of the x

Plutonium assay calorimeters

International Nuclear Information System (INIS)

Perry, R.B.

1978-01-01

Three calorimeters were developed for the IAEA: a small-sample portable calorimeter, a bulk calorimeter for up to 2 kg Pu in cans and capable of measuring up to 25 watts, and a calorimeter for 4-m long LWR Pu-recycle fuel roads. Design parameters and performance capability are given, and the instruments are compared with those developed for NRC

Performance of the ATLAS hadronic Tile Calorimeter in Run-2 and its upgrade for the High Luminosity LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00223789; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for energy reconstruction of hadrons, jets, tauparticles and missing transverse energy. TileCal is a scintillator-steel sampling calorimeter and it covers the region of pseudo-rapidity up to 1.7, with almost 10000 channels measuring energies ranging from ∼30 MeV to ∼2 TeV. Each stage of the signal production, from scintillation light to the signal reconstruction, is monitored and calibrated. The performance of the Tile calorimeter has been studied in-situ employing cosmic ray muons and a large sample of proton-proton collisions, acquired during the operations of the LHC. Prompt isolated muons of high momentum from electroweak bosons decays are employed to study the energy response of the calorimeter at the electromagnetic scale. The calorimeter response to hadronic particles is evaluated with a sample of isolated hadrons. The modelling of the response by the Monte Carlo simulation is discussed. T...

Polymer dual ring resonators for label-free optical biosensing using microfluidics.

Science.gov (United States)

Salleh, Muhammad H M; Glidle, Andrew; Sorel, Marc; Reboud, Julien; Cooper, Jonathan M

2013-04-18

We demonstrate a polymer resonator microfluidic biosensor that overcomes the complex manufacturing procedures required to fabricate traditional devices. In this new format, we show that a gapless light coupling photonic configuration, fabricated in SU8 polymer, can achieve high sensitivity, label-free chemical sensing in solution and high sensitivity biological sensing, at visible wavelengths.

Silicon photomultipliers. Properties and applications in a highly granular calorimeter

International Nuclear Information System (INIS)

Feege, Nils

2008-12-01

Silicon Photomultipliers (SiPMs) are novel semiconductor-based photodetectors operated in Geiger mode. Their response is not linear, and both their gain and their photon detection efficiency depend on the applied bias voltage and on temperature. The CALICE collaboration investigates several technology options for highly granular calorimeters for the future ILC. The prototype of a scintillator-steel sampling calorimeter with analogue readout for hadrons constructed at DESY and successfully operated in testbeam experiments at DESY, CERN and FNAL by this collaboration is the first large scale application for 7608 SiPMs developed by MEPhI. This thesis deals with properties of the SiPMs used in the calorimeter prototype. The effective numer of pixels of the SiPMs, which influences their saturation behaviour, is extracted from in situ measurements and compared to results obtained for the bare SiPMs. In addition, the effects of temperature and voltage changes on the parameters necessary for the calibration of the SiPMs and the detector are determined. Methods which allow for correcting or compensating these effects are evaluated. An approach to improve the absolute calibration of the temperature sensors in the prototype is described and temperature profiles are studied. Finally, a procedure to adjust the light yield of the cells of the prototype is presented. The results of the application of this procedure during the commissioning of the detector at FNAL are discussed. (orig.)

Silicon photomultipliers. Properties and applications in a highly granular calorimeter

Energy Technology Data Exchange (ETDEWEB)

Feege, Nils

2008-12-15

Silicon Photomultipliers (SiPMs) are novel semiconductor-based photodetectors operated in Geiger mode. Their response is not linear, and both their gain and their photon detection efficiency depend on the applied bias voltage and on temperature. The CALICE collaboration investigates several technology options for highly granular calorimeters for the future ILC. The prototype of a scintillator-steel sampling calorimeter with analogue readout for hadrons constructed at DESY and successfully operated in testbeam experiments at DESY, CERN and FNAL by this collaboration is the first large scale application for 7608 SiPMs developed by MEPhI. This thesis deals with properties of the SiPMs used in the calorimeter prototype. The effective numer of pixels of the SiPMs, which influences their saturation behaviour, is extracted from in situ measurements and compared to results obtained for the bare SiPMs. In addition, the effects of temperature and voltage changes on the parameters necessary for the calibration of the SiPMs and the detector are determined. Methods which allow for correcting or compensating these effects are evaluated. An approach to improve the absolute calibration of the temperature sensors in the prototype is described and temperature profiles are studied. Finally, a procedure to adjust the light yield of the cells of the prototype is presented. The results of the application of this procedure during the commissioning of the detector at FNAL are discussed. (orig.)

Microfluidics to Mimic Blood Flow in Health and Disease

Science.gov (United States)

Sebastian, Bernhard; Dittrich, Petra S.

2018-01-01

Throughout history, capillary systems have aided the establishment of the fundamental laws of blood flow and its non-Newtonian properties. The advent of microfluidics technology in the 1990s propelled the development of highly integrated lab-on-a-chip platforms that allow highly accurate replication of vascular systems' dimensions, mechanical properties, and biological complexity. Applications include the detection of pathological changes to red blood cells, white blood cells, and platelets at unparalleled sensitivity and the efficacy assessment of drug treatment. Recent efforts have aimed at the development of microfluidics-based tests usable in a clinial environment or the replication of more complex diseases such as thrombosis. These microfluidic disease models enable the study of onset and progression of disease as well as the identification of key players and risk factors, which have led to a spectrum of clinically relevant findings.

PEP-4 geiger-mode hexagonal calorimeter

International Nuclear Information System (INIS)

Wenzel, W.A.

1982-01-01

The design and performance of the calorimeter are briefly described. Design aspects include illustrations of the active volume of the detector, edge connections, module assembly and analog electronics. Performance data for cosmic rays and radiation sources, including efficiency and channel sensitivity are discussed

Upgrade of the ATLAS hadronic Tile calorimeter for the High luminosity LHC

CERN Document Server

Asensi Tortajada, Ignacio; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS detector at the LHC. It is a sampling calorimeter consisting of alternating thin steel plates and scintillating tiles. Wavelength shifting fibers coupled to the tiles collect the produced light and are read out by photomultiplier tubes. An analog sum of the processed signal of several photomultipliers serves as input to the first level of trigger. Photomultiplier signals are then digitized at 40 MHz and stored on detector and are only transferred off detector once the first level trigger acceptance has been confirmed (at a rate of maximum 100 kHz). The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade, in 2024, will accommodate the upgrade of the detector and data acquisition system for the HL-LHC. In particular, TileCal will undergo a major replacement of its on- and of...

Development of Position-Sensitive Magnetic Calorimeters for X-Ray Astronomy

Science.gov (United States)

Bandler, SImon; Stevenson, Thomas; Hsieh, Wen-Ting

2011-01-01

Metallic magnetic calorimeters (MMC) are one of the most promising devices to provide very high energy resolution needed for future astronomical x-ray spectroscopy. MMC detectors can be built to large detector arrays having thousands of pixels. Position-sensitive magnetic (PoSM) microcalorimeters consist of multiple absorbers thermally coupled to one magnetic micro calorimeter. Each absorber element has a different thermal coupling to the MMC, resulting in a distribution of different pulse shapes and enabling position discrimination between the absorber elements. PoSMs therefore achieve the large focal plane area with fewer number of readout channels without compromising spatial sampling. Excellent performance of PoSMs was achieved by optimizing the designs of key parameters such as the thermal conductance among the absorbers, magnetic sensor, and heat sink, as well as the absorber heat capacities. Micro fab ri - cation techniques were developed to construct four-absorber PoSMs, in which each absorber consists of a two-layer composite of bismuth and gold. The energy resolution (FWHM full width at half maximum) was measured to be better than 5 eV at 6 keV x-rays for all four absorbers. Position determination was demonstrated with pulse-shape discrimination, as well as with pulse rise time. X-ray microcalorimeters are usually designed to thermalize as quickly as possible to avoid degradation in energy resolution from position dependence to the pulse shapes. Each pixel consists of an absorber and a temperature sensor, both decoupled from the cold bath through a weak thermal link. Each pixel requires a separate readout channel; for instance, with a SQUID (superconducting quantum interference device). For future astronomy missions where thousands to millions of resolution elements are required, having an individual SQUID readout channel for each pixel becomes difficult. One route to attaining these goals is a position-sensitive detector in which a large continuous or

Testing of a Microfluidic Sampling System for High Temperature Electrochemical MC&A

Energy Technology Data Exchange (ETDEWEB)

Pereira, Candido [Argonne National Lab. (ANL), Argonne, IL (United States); Nichols, Kevin [Argonne National Lab. (ANL), Argonne, IL (United States)

2013-11-27

This report describes the preliminary validation of a high-temperature microfluidic chip system for sampling of electrochemical process salt. Electroanalytical and spectroscopic techniques are attractive candidates for improvement through high-throughput sample analysis via miniaturization. Further, microfluidic chip systems are amenable to micro-scale chemical processing such as rapid, automated sample purification to improve sensor performance. The microfluidic chip was tested to determine the feasibility of the system for high temperature applications and conditions under which microfluidic systems can be used to generate salt droplets at process temperature to support development of material balance and control systems in a used fuel treatment facility. In FY13, the project focused on testing a quartz microchip device with molten salts at near process temperatures. The equipment was installed in glove box and tested up to 400°C using commercial thermal transfer fluids as the carrier phase. Preliminary tests were carried out with a low-melting halide salt to initially characterize the properties of this novel liquid-liquid system and to investigate the operating regimes for inducing droplet flow within candidate carrier fluids. Initial results show that the concept is viable for high temperature sampling but further development is required to optimize the system to operate with process relevant molten salts.

Microfluidic biosensor for β-Hydroxybutyrate (βHBA) determination of subclinical ketosis diagnosis.

Science.gov (United States)

Weng, Xuan; Zhao, Wenting; Neethirajan, Suresh; Duffield, Todd

2015-02-12

Determination of β-hydroxybutyrate (βHBA) is a gold standard for diagnosis of Subclinical Ketosis (SCK), a common disease in dairy cows that causes significant economic loss. Early detection of SCK can help reduce the risk of the disease progressing into clinical stage, thus minimizing economic losses on dairy cattle. Conventional laboratory methods are time consuming and labor-intensive, requiring expensive and bulky equipment. Development of portable and robust devices for rapid on-site SCK diagnosis is an effective way to prevent and control ketosis and can significantly aid in the management of dairy animal health. Microfluidic technology provides a rapid, cost-effective way to develop handheld devices for on-farm detection of sub-clinical ketosis. In this study, a highly sensitive microfluidics-based biosensor for on-site SCK diagnosis has been developed. A rapid, low-cost microfluidic biosensor with high sensitivity and specificity was developed for SCK diagnosis. Determination of βHBA was employed as the indicator in the diagnosis of SCK. On-chip detection using miniaturized and cost-effective optical sensor can be finished in 1 minute with a detection limit of 0.05 mM concentration. Developed microfluidic biosensor was successfully tested with the serum samples from dairy cows affected by SCK. The results of the developed biosensor agreed well with two other laboratory methods. The biosensor was characterized by high sensitivity and specificity towards βHBA with a detection limit of 0.05 mM. The developed microfluidic biosensor provides a promising prototype for a cost-effective handheld meter for on-site SCK diagnosis. By using microfluidic method, the detection time is significantly decreased compared to other laboratory methods. Here, we demonstrate a field-deployable device to precisely identify and measure subclinical ketosis by specific labeling and quantification of β-hydroxybutyate in cow blood samples. A real-time on-site detection system will

Review of Recent Metamaterial Microfluidic Sensors

Directory of Open Access Journals (Sweden)

Ahmed Salim

2018-01-01

Full Text Available Metamaterial elements/arrays exhibit a sensitive response to fluids yet with a small footprint, therefore, they have been an attractive choice to realize various sensing devices when integrated with microfluidic technology. Micro-channels made from inexpensive biocompatible materials avoid any contamination from environment and require only microliter–nanoliter sample for sensing. Simple design, easy fabrication process, light weight prototype, and instant measurements are advantages as compared to conventional (optical, electrochemical and biological sensing systems. Inkjet-printed flexible sensors find their utilization in rapidly growing wearable electronics and health-monitoring flexible devices. Adequate sensitivity and repeatability of these low profile microfluidic sensors make them a potential candidate for point-of-care testing which novice patients can use reliably. Aside from degraded sensitivity and lack of selectivity in all practical microwave chemical sensors, they require an instrument, such as vector network analyzer for measurements and not readily available as a self-sustained portable sensor. This review article presents state-of-the-art metamaterial inspired microfluidic bio/chemical sensors (passive devices ranging from gigahertz to terahertz range with an emphasis on metamaterial sensing circuit and microfluidic detection. We also highlight challenges and strategies to cope these issues which set future directions.

Multi-Anode Photomultplier (MAPMT) readout for High Granularity Calorimeters

CERN Document Server

Mkrtchyan, Tigran; The ATLAS collaboration

2017-01-01

Hadron calorimeter high performance in jet sub-structure measurements can be achieved for objects with $p_{T}$ greater than 1 TeV if the readout geometry is finely segmented in $\\Delta\\eta \\times \\Delta\\phi$. A feasibility study to increase the readout granularity of TileCal, the central hadron calorimeter of the ATLAS detector, is presented. We show a preliminary study exploring the possibility to increase by a factor 4 the present readout granularity of the inner layer cells of TileCal (0.1->0.025 in $\\Delta\\eta$) and to split into two layers the intermediate section of TileCal. The proposed solution is designed to cope with mechanical and readout bandwidth and power constraints. Assuming that the mechanics of the Tile modules cannot be changed, Multi-Anode PMTs with same boundary geometry of the present single-anode PMTs are considered to readout WLS bers, ideally one per pixel, carrying the signals from the individual scintillating tiles of each detector cells. The discussed challenges of the design are: ...

Paper-based microfluidics with high resolution, cut on a glass fiber membrane for bioassays.

Science.gov (United States)

Fang, Xueen; Wei, Shasha; Kong, Jilie

2014-03-07

In this report, we describe a simple, low-cost, straight forward and highly reproducible fabrication method of microfluidic systems. This system was cut on a glass fiber membrane by a common cutter without using any other sophisticated equipment or organic solvents. This format represents a novel type of paper-based microfluidics with high resolution of the microchannel down to ~137 μm, comparable to those made by conventional photolithography. We successfully applied this method to microfluidics to create a star micro-array format of multiplexed urine tests in this study.

Fabrication of polyimide based microfluidic channels for biosensor devices

Science.gov (United States)

Zulfiqar, Azeem; Pfreundt, Andrea; Svendsen, Winnie Edith; Dimaki, Maria

2015-03-01

The ever-increasing complexity of the fabrication process of Point-of-care (POC) devices, due to high demand of functional versatility, compact size and ease-of-use, emphasizes the need of multifunctional materials that can be used to simplify this process. Polymers, currently in use for the fabrication of the often needed microfluidic channels, have limitations in terms of their physicochemical properties. Therefore, the use of a multipurpose biocompatible material with better resistance to the chemical, thermal and electrical environment, along with capability of forming closed channel microfluidics is inevitable. This paper demonstrates a novel technique of fabricating microfluidic devices using polyimide (PI) which fulfills the aforementioned properties criteria. A fabrication process to pattern microfluidic channels, using partially cured PI, has been developed by using a dry etching method. The etching parameters are optimized and compared to those used for fully cured PI. Moreover, the formation of closed microfluidic channel on wafer level by bonding two partially cured PI layers or a partially cured PI to glass with high bond strength has been demonstrated. The reproducibility in uniformity of PI is also compared to the most commonly used SU8 polymer, which is a near UV sensitive epoxy resin. The potential applications of PI processing are POC and biosensor devices integrated with microelectronics.

Offline Reconstruction Algorithms for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Chen, Z; Meschi, Emilio; Scott, Edward John Titman; Seez, Christopher

2017-01-01

The upgraded High Luminosity LHC, after the third Long Shutdown (LS3), will provide an instantaneous luminosity of $7.5 \\times 10^{34}$ cm$^{-2}$ s$^{-1}$ (levelled), at theCollaboration price of extreme pileup of up to 200 interactions per crossing. Such extreme pileup poses significant challenges, in particular for forward calorimetry. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic and hadronic compartments. The electromagnetic and a large fraction of the hadronic portions will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the hadronic portion based on highly-segmented scintillators with SiPM readout. Offline clustering algorithms that make use of this extreme granularity require novel approaches to preserve the fine structure of showers and to be stable against pileup, wh...

Upgrade of the ATLAS Liquid Argon Calorimeters for the High-Luminosity LHC

CERN Document Server

McCarthy, Tom; The ATLAS collaboration

2016-01-01

The increased particle flux at the high luminosity phase of the Large Hadron Collider (HL-LHC), with instantaneous luminosities of up to 7.5 times the original design value, will have an impact on many sub-systems of the ATLAS detector. This contribution highlights the particular impacts on the ATLAS liquid argon calorimeter system, together with an overview of the various upgrade plans leading up to the HL-LHC. The higher luminosities are of particular importance for the forward calorimeters (FCal), where the expected increase in the ionization load poses a number of problems that can degrade the FCal performance such as beam heating and space-charge effects in the liquid argon gaps and high-voltage drop due to increased current drawn over the current-limiting resistors. A proposed FCal replacement as a way to counter some of these problems is weighed against the risks associated with the replacement. To further mitigate the effects of increased pile-up, the installation of a high-granularity timing detector...

Large-area hexagonal silicon detectors for the CMS High Granularity Calorimeter

Science.gov (United States)

Pree, E.

2018-02-01

During the so-called Phase-2 Upgrade, the CMS experiment at CERN will undergo significant improvements to cope with the 10-fold luminosity increase of the High Luminosity LHC (HL-LHC) era. Especially the forward calorimetry will suffer from very high radiation levels and intensified pileup in the detectors. For this reason, the CMS collaboration is designing a High Granularity Calorimeter (HGCAL) to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The CE-E and a large fraction of CE-H will consist of a sandwich structure with silicon as active detector material. This paper presents an overview of the ongoing sensor development for the HGCAL and highlights important design features and measurement techniques. The design and layout of an 8-inch silicon sensor prototype is shown. The hexagonal sensors consist of 235 pads, each with an area of about 1 cm2. Furthermore, Synopsys TCAD simulations regarding the high voltage stability of the sensors for different geometric parameters are performed. Finally, two different IV characterisation methods are compared on the same sensor.

The ATLAS liquid argon calorimeter high-voltage system: commissioning, optimisation, and LHC relative luminosity measurement.

CERN Document Server

Arfaoui, Samir; Monnier, E

2011-01-01

The main goals of the ATLAS scientific programme are the observation or exclusion of physics beyond the Standard Model (SM), as well as the measurement of production cross-sections of SM processes. In oder to do so,it is important to measure the luminosity at the interaction point with great precision. The ATLAS luminosity is extracted using several detectors with varying efficiencies and acceptances. Different methods, such as inclusive - or coincidence - event counting and calorimeter integrated current measurements, are calibrated and cross-compared to provide the most accurate luminosity determination. In order to provide more cross-checks and a better control on the systematic uncertainties, an independent measurement using the liquid argon (LAr) forward calorimeter (FCal), based on the readout current of its high-voltage system, has been developed. This document describes how the LAr calorimeter high-voltage system has been installed and commissioned, as well as its application to a relative luminosity ...

The ATLAS liquid argon calorimeter high-voltage system: commissioning, optimisation and LHC relative luminosity measurement

International Nuclear Information System (INIS)

Arfaoui, S.

2011-10-01

The main goals of the ATLAS scientific programme are the observation or exclusion of physics beyond the Standard Model (SM), as well as the measurement of production cross-sections of SM processes. In order to do so, it is important to measure the luminosity at the interaction point with great precision. The ATLAS luminosity is extracted using several detectors with varying efficiencies and acceptances. Different methods, such as inclusive - or coincidence - event counting and calorimeter integrated current measurements, are calibrated and cross-compared to provide the most accurate luminosity determination. In order to provide more cross-checks and a better control on the systematic uncertainties, an independent measurement using the liquid argon (LAr) forward calorimeter (FCal), based on the readout current of its high-voltage system, has been developed. This document describes how the LAr calorimeter high-voltage system has been installed and commissioned, as well as its application to a relative luminosity determination. (author)

Microfluidic Scintillation Detectors for High Energy Physics

CERN Document Server

Maoddi, Pietro; Mapelli, Alessandro

This thesis deals with the development and study of microfluidic scintillation detectors, a technology of recent introduction for the detection of high energy particles. Most of the interest for such devices comes from the use of a liquid scintillator, which entails the possibility of changing the active material in the detector, leading to increased radiation resistance. A first part of the thesis focuses on the work performed in terms of design and modelling studies of novel prototype devices, hinting to new possibilities and applications. In this framework, the simulations performed to validate selected designs and the main technological choices made in view of their fabrication are addressed. The second part of this thesis deals with the microfabrication of several prototype devices. Two different materials were studied for the manufacturing of microfluidic scintillation detectors, namely the SU-8 photosensitive epoxy and monocrystalline silicon. For what concerns the former, an original fabrication appro...

Easy fabrication of high quality nickel mold for deep polymer microfluidic channels

International Nuclear Information System (INIS)

Wong, Ten It; Tan, Christina Yuan Ling; Zhou, Xiaodong; Limantoro, Julian; Fong, Kin Phang; Quan, Chenggen; Sun, Ling Ling

2016-01-01

Mass fabrication of disposable microfluidic chips with hot embossing is a key technology for microfluidic chip based biosensors. In this work, we develop a new method of fabricating high quality and highly durable nickel molds for hot embossing polymer chips. The process involves the addition of a thick, patterned layer of negative photoresist AZ-125nxT to a 4″ silicon wafer, followed by nickel electroplating and delamination of the nickel mold. Our investigations found that compared to a pillar mask, a hole mask can minimize the diffraction effect in photolithography of a thick photoresist, reduce the adhesion of the AZ-125nxT to the photomask in photolithography, and facilitate clean development of the photoresist patterns. By optimizing the hot embossing and chip bonding parameters, microfluidic chips with deep channels are achieved. (paper)

LHCb calorimeter electronics. Photon identification. Calorimeter calibration

International Nuclear Information System (INIS)

Machefert, F.

2011-01-01

LHCb is one of the four large experiments installed on the LHC accelerator ring. The aim of the detector is to precisely measure CP violation observables and rare decays in the B meson sector. The calorimeter system of LHCb is made of four sub-systems: the scintillating pad detector, the pre-shower, the electromagnetic (ECAL) and hadronic (HCAL) calorimeters. It is essential to reconstruct B decays, to efficiently trigger on interesting events and to identify electrons and photons. After a review of the LHCb detector sub-systems, the first part of this document describes the calorimeter electronics. First, the front-end electronics in charge of measuring the ECAL and HCAL signals from the photomultipliers is presented, then the following section is an overview of the control card of the four calorimeters. The chapters three and four concern the test software of this electronics and the technological choices making it tolerant to radiations in the LHCb cavern environment. The measurements performed to ensure this tolerance are also given. The second part of this document concerns both the identification of the photons with LHCb and the calibration of the calorimeters. The photon identification method is presented and the performances given. Finally, the absolute energy calibration of the PRS and ECAL, based on the data stored in 2010 is explained. (author)

Preliminary study on field buses for the control system of the high voltage of the ATLAS hadronic calorimeter

International Nuclear Information System (INIS)

Drevet, F.; Chadelas, R.; Montarou, G.

1996-01-01

We present here after a preliminary study on field buses for the control system of the high voltage of the photomultipliers of the TILECAL calorimeter. After some generalities, different commercial buses are reviewed (CAN, ARCET, WorldFIP, Profibus and LonWorks). The Profibus and LonWorks solution are more extensively studies as a possible solution for the high voltage system of the TILE hadronic calorimeter. (authors)

Upgrading the Fast Calorimeter Simulation in ATLAS

CERN Document Server

Schaarschmidt, Jana; The ATLAS collaboration

2017-01-01

The tremendous need for simulated samples now and even more so in the future, encourage the development of fast simulation techniques. The Fast Calorimeter Simulation is a faster though less accurate alternative to the full calorimeter simulation with Geant4. It is based on parametrizing the longitudunal and lateral energy deposits of single particles in the ATLAS calorimeter. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. The parametrizations are expanded to cover very high energies and very forward detector regions, to increase the applicability of the tool. A prototype of this upgraded Fast Calorimeter Simulation has been developed and first validations with single particles show substantial improvements over the previous version.

Electronics and triggering challenges for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Borg, Johan

2017-01-01

The High Granularity Calorimeter (HGCAL) is presently being designedto replace the CMS endcap calorimeters for the HighLuminosity phase at LHC. It will feature six million silicon sensor channelsand 52 longitudinal layers. The requirements for the frontendelectronics include a 0.3 fC-10 pC dynamic range, low noise (2000 e-) and low power consumption (10 mW /channel).In addition, the HGCAL will perform 50 ps resolution time of arrivalmeasurements to combat the effect of the large number of interactions taking placeat each bunch crossing, and will transmit both triggered readoutfrom on-detector buffer memory and reduced resolution real-time trigger data.We present the challenges related to the frontend electronics, data transmissionand off-detector trigger preprocessing that must be overcome, and the designconcepts currently being pursued.

A completely automated flow, heat-capacity, calorimeter for use at high temperatures and pressures

Science.gov (United States)

Rogers, P. S. Z.; Sandarusi, Jamal

1990-11-01

An automated, flow calorimeter has been constructed to measure the isobaric heat capacities of concentrated, aqueous electrolyte solutions using a differential calorimetry technique. The calorimeter is capable of operation to 700 K and 40 MPa with a measurement accuracy of 0.03% relative to the heat capacity of the pure reference fluid (water). A novel design encloses the calorimeter within a double set of separately controlled, copper, adiabatic shields that minimize calorimeter heat losses and precisely control the temperature of the inlet fluids. A multistage preheat train, used to efficiently heat the flowing fluid, includes a counter-current heat exchanger for the inlet and outlet fluid streams in tandem with two calorimeter preheaters. Complete system automation is accomplished with a distributed control scheme using multiple processors, allowing the major control tasks of calorimeter operation and control, data logging and display, and pump control to be performed simultaneously. A sophisticated pumping strategy for the two separate syringe pumps allows continuous fluid delivery. This automation system enables the calorimeter to operate unattended except for the reloading of sample fluids. In addition, automation has allowed the development and implementation of an improved heat loss calibration method that provides calorimeter calibration with absolute accuracy comparable to the overall measurement precision, even for very concentrated solutions.

Design and Prototyping of a High Granularity Scintillator Calorimeter

International Nuclear Information System (INIS)

Zutshi, Vishnu

2016-01-01

A novel approach for constructing fine-granularity scintillator calorimeters, based on the concept of an Integrated Readout Layer (IRL) was developed. The IRL consists of a printed circuit board inside the detector which supports the directly-coupled scintillator tiles, connects to the surface-mount SiPMs and carries the necessary front-end electronics and signal/bias traces. Prototype IRLs using this concept were designed, prototyped and successfully exposed to test beams. Concepts and implementations of an IRL carried out with funds associated with this contract promise to result in the next generation of scintillator calorimeters.

Design and Prototyping of a High Granularity Scintillator Calorimeter

Energy Technology Data Exchange (ETDEWEB)

Zutshi, Vishnu [Northern Illinois Univ., DeKalb, IL (United States). Dept. of Physics

2016-03-27

A novel approach for constructing fine-granularity scintillator calorimeters, based on the concept of an Integrated Readout Layer (IRL) was developed. The IRL consists of a printed circuit board inside the detector which supports the directly-coupled scintillator tiles, connects to the surface-mount SiPMs and carries the necessary front-end electronics and signal/bias traces. Prototype IRLs using this concept were designed, prototyped and successfully exposed to test beams. Concepts and implementations of an IRL carried out with funds associated with this contract promise to result in the next generation of scintillator calorimeters.

METROLOGICAL PERFORMANCES OF BOMB CALORIMETERS AT REAL CONDITIONS

Directory of Open Access Journals (Sweden)

Yu. V. Maksimuk

2016-01-01

Full Text Available The high-usage measurement equipment for heat of combustion of organic fuels are bomb isoperibol calorimeters with a water thermostat. The stability of work of calorimeters at real conditions is important for maintenance of reliability of measurement results. The article purpose – the analysis of stability for parameters of calorimeters to environment changes. In this work influence room temperature (Тк and heat exchange conditions on metrological characteristics of two models of calorimeters is considered with different degree of thermal protection: V-08МА and BIC 100. For calorimeters V-08МА the increase in a effective heat capacity (W on 0,1 % by growth of Tк on everyone 5 °С is established. To use value W in all interval laboratory temperatures Tк = 14–28 °С it is necessary to correct W on 2,8 J/°C on everyone 1 °С changes of Tк. Updating W is required, if the correction exceeds error in determination W. For calorimeter BIC 100 it is not revealed dependences W from Tк. BIC 100 have constant-temperature cap, high stability a temperature in thermostat and stabilized heat exchange. It is established that an standard deviation of cooling constant for all calorimeters in direct proportional to standard deviation W. 

Resonator graphene microfluidic antenna (RGMA) for blood glucose detection

Science.gov (United States)

Jizat, Noorlindawaty Md.; Mohamad, Su Natasha; Ishak, Muhammad Ikman

2017-09-01

Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show a resonator graphene microfluidic antenna (RGMA) is used to detect the dielectric properties of aqueous glucose solution which represent the glucose level in blood. Simulation verified the high sensitivity of proposed RGMA made with aqueous glucose solutions at different concentrations. The RGMA yielded a sensor sensitivity of 0.1882GHz/mgml-1 as plotted from the slope of the linear fit from the result averages in S11 and S21 parameter, respectively. This results indicate that the proposed resonator antenna achieves high sensitivity and linear to the changes of glucose concentration.

Monte Carlo simulation of a gas-sampled hadron calorimeter

Energy Technology Data Exchange (ETDEWEB)

Chang, C Y; Kunori, S; Rapp, P; Talaga, R; Steinberg, P; Tylka, A J; Wang, Z M

1988-02-15

A prototype of the OPAL barrel hadron calorimeter, which is a gas-sampled calorimeter using plastic streamer tubes, was exposed to pions at energies between 1 and 7 GeV. The response of the detector was simulated using the CERN GEANT3 Monte Carlo program. By using the observed high energy muon signals to deduce details of the streamer formation, the Monte Carlo program was able to reproduce the observed calorimeter response. The behavior of the hadron calorimeter when placed behind a lead glass electromagnetic calorimeter was also investigated.

IFSA: a microfluidic chip-platform for frit-based immunoassay protocols

Science.gov (United States)

Hlawatsch, Nadine; Bangert, Michael; Miethe, Peter; Becker, Holger; Gärtner, Claudia

2013-03-01

Point-of-care diagnostics (POC) is one of the key application fields for lab-on-a-chip devices. While in recent years much of the work has concentrated on integrating complex molecular diagnostic assays onto a microfluidic device, there is a need to also put comparatively simple immunoassay-type protocols on a microfluidic platform. In this paper, we present the development of a microfluidic cartridge using an immunofiltration approach. In this method, the sandwich immunoassay takes place in a porous frit on which the antibodies have immobilized. The device is designed to be able to handle three samples in parallel and up to four analytical targets per sample. In order to meet the critical cost targets for the diagnostic market, the microfluidic chip has been designed and manufactured using high-volume manufacturing technologies in mind. Validation experiments show comparable sensitivities in comparison with conventional immunofiltration kits.

Design, Performance, and Calibration of the CMS Hadron-Outer Calorimeter

CERN Document Server

Abdullin, Salavat; Acharya, Bannaje Sripathi; Adam, Nadia; Adams, Mark Raymond; Akchurin, Nural; Akgun, Ugur; Albayrak, Elif Asli; Anderson, E Walter; Antchev, Georgy; Arcidy, M; Ayan, S; Aydin, Sezgin; Aziz, Tariq; Baarmand, Marc M; Babich, Kanstantsin; Baden, Drew; Bakirci, Mustafa Numan; Banerjee, Sunanda; Banerjee, Sudeshna; Bard, Robert; Barnes, Virgil E; Bawa, Harinder Singh; Baiatian, G; Bencze, Gyorgy; Beri, Suman Bala; Berntzon, Lisa; Bhatnagar, Vipin; Bhatti, Anwar; Bodek, Arie; Bose, Suvadeep; Bose, Tulika; Budd, Howard; Burchesky, Kyle; Camporesi, Tiziano; Cankocak, Kerem; Carrell, Kenneth Wayne; Cerci, Salim; Chendvankar, Sanjay; Chung, Yeon Sei; Clarida, Warren; Cremaldi, Lucien Marcus; Cushman, Priscilla; Damgov, Jordan; De Barbaro, Pawel; Debbins, Paul; Deliomeroglu, Mehmet; Demianov, A; de Visser, Theo; Deshpande, Pandurang Vishnu; Díaz, Jonathan; Dimitrov, Lubomir; Dugad, Shashikant; Dumanoglu, Isa; Duru, Firdevs; Efthymiopoulos, I; Elias, John E; Elvira, D; Emeliantchik, Igor; Eno, Sarah Catherine; Ershov, Alexander; Erturk, Sefa; Esen, Selda; Eskut, Eda; Fenyvesi, Andras; Fisher, Wade Cameron; Freeman, Jim; Ganguli, Som N; Gaultney, Vanessa; Gamsizkan, Halil; Gavrilov, Vladimir; Genchev, Vladimir; Gleyzer, Sergei V; Golutvin, Igor; Goncharov, Petr; Grassi, Tullio; Green, Dan; Gribushin, Andrey; Grinev, B; Gurtu, Atul; Murat Güler, A; Gülmez, Erhan; Gümüs, K; Haelen, T; Hagopian, Sharon; Hagopian, Vasken; Halyo, Valerie; Hashemi, Majid; Hauptman, John M; Hazen, Eric; Heering, Arjan Hendrix; Heister, Arno; Hunt, Adam; Ilyina, N; Ingram, D; Isiksal, Engin; Jarvis, Chad; Jeong, Chiyoung; Johnson, Kurtis F; Jones, John; Kaftanov, Vitali; Kalagin, Vladimir; Kalinin, Alexey; Kalmani, Suresh Devendrappa; Karmgard, Daniel John; Kaur, Manjit; Kaya, Mithat; Kaya, Ozlem; Kayis-Topaksu, A; Kellogg, Richard G; Khmelnikov, Alexander; Kim, Heejong; Kisselevich, I; Kodolova, Olga; Kohli, Jatinder Mohan; Kolossov, V; Korablev, Andrey; Korneev, Yury; Kosarev, Ivan; Kramer, Laird; Krinitsyn, Alexander; Krishnaswamy, Marthi Ramaswamy; Krokhotin, Andrey; Kryshkin, V; Kuleshov, Sergey; Kumar, Arun; Kunori, Shuichi; Laasanen, Alvin T; Ladygin, Vladimir; Laird, Edward; Landsberg, Greg; Laszlo, Andras; Lawlor, C; Lazic, Dragoslav; Lee, Sang Joon; Levchuk, Leonid; Linn, Stephan; Litvintsev, Dmitri; Lobolo, L; Los, Serguei; Lubinsky, V; Lukanin, Vladimir; Ma, Yousi; Machado, Emanuel; Maity, Manas; Majumder, Gobinda; Mans, Jeremy; Marlow, Daniel; Markowitz, Pete; Martínez, German; Mazumdar, Kajari; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mescheryakov, G; Mestvirishvili, Alexi; Miller, Michael; Möller, A; Mohammadi-Najafabadi, M; Moissenz, P; Mondal, Naba Kumar; Mossolov, Vladimir; Nagaraj, P; Narasimham, Vemuri Syamala; Norbeck, Edwin; Olson, Jonathan; Onel, Yasar; Onengüt, G; Ozkan, Cigdem; Ozkurt, Halil; Ozkorucuklu, Suat; Ozok, Ferhat; Paktinat, S; Pal, Andras; Patil, Mandakini Ravindra; Penzo, Aldo; Petrushanko, Sergey; Petrosian, A; Pikalov, Vladimir; Piperov, Stefan; Podrasky, V; Polatoz, A; Pompos, Arnold; Popescu, Sorina; Posch, C; Pozdnyakov, Andrey; Qian, Weiming; Ralich, Robert; Reddy, L; Reidy, Jim; Rogalev, Evgueni; Roh, Youn; Rohlf, James; Ronzhin, Anatoly; Ruchti, Randy; Ryazanov, Anton; Safronov, Grigory; Sanders, David A; Sanzeni, Christopher; Sarycheva, Ludmila; Satyanarayana, B; Schmidt, Ianos; Sekmen, Sezen; Semenov, Sergey; Senchishin, V; Sergeyev, S; Serin, Meltem; Sever, Ramazan; Singh, B; Singh, Jas Bir; Sirunyan, Albert M; Skuja, Andris; Sharma, Seema; Sherwood, Brian; Shumeiko, Nikolai; Smirnov, Vitaly; Sogut, Kenan; Sonmez, Nasuf; Sorokin, Pavel; Spezziga, Mario; Stefanovich, R; Stolin, Viatcheslav; Sudhakar, Katta; Sulak, Lawrence; Suzuki, Ichiro; Talov, Vladimir; Teplov, Konstantin; Thomas, Ray; Tonwar, Suresh C; Topakli, Huseyin; Tully, Christopher; Turchanovich, L; Ulyanov, A; Vanini, A; Vankov, Ivan; Vardanyan, Irina; Varela, F; Vergili, Mehmet; Verma, Piyush; Vesztergombi, Gyorgy; Vidal, Richard; Vishnevskiy, Alexander; Vlassov, E; Vodopiyanov, Igor; Volobouev, Igor; Volkov, Alexey; Volodko, Anton; Wang, Lei; Werner, Jeremy Scott; Wetstein, Matthew; Winn, Dave; Wigmans, Richard; Whitmore, Juliana; Wu, Shouxiang; Yazgan, Efe; Yetkin, Taylan; Zálán, Peter; Zarubin, Anatoli; Zeyrek, Mehmet

2008-01-01

The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with an outer calorimeter to ensure high energy shower containment in the calorimeter. Fabrication, testing and calibration of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing $\\et$ measurements at LHC energies. The outer hadron calorimeter will also be used for the muon trigger in coincidence with other muon chambers in CMS.

Fast infectious diseases diagnostics based on microfluidic biochip system

Directory of Open Access Journals (Sweden)

Qin Huang

2017-03-01

Full Text Available Molecular diagnostics is one of the most important tools currently in use for clinical pathogen detection due to its high sensitivity, specificity, and low consume of sample and reagent is keyword to low cost molecular diagnostics. In this paper, a sensitive DNA isothermal amplification method for fast clinical infectious diseases diagnostics at aM concentrations of DNA was developed using a polycarbonate (PC microfluidic chip. A portable confocal optical fluorescence detector was specifically developed for the microfluidic chip that was capable of highly sensitive real-time detection of amplified products for sequence-specific molecular identification near the optical diffraction limit with low background. The molecular diagnostics of Listeria monocytogenes with nucleic acid extracted from stool samples was performed at a minimum DNA template concentration of 3.65aM, and a detection limit of less than five copies of genomic DNA. Contrast to the general polymerase chain reaction (PCR at eppendorf (EP tube, the detection time in our developed method was reduced from 1.5h to 45min for multi-target parallel detection, the consume of sample and reagent was dropped from 25μL to 1.45μL. This novel microfluidic chip system and method can be used to develop a micro total analysis system as a clinically relevant pathogen molecular diagnostics method via the amplification of targets, with potential applications in biotechnology, medicine, and clinical molecular diagnostics.

Accelerated Biofluid Filling in Complex Microfluidic Networks by Vacuum-Pressure Accelerated Movement (V-PAM).

Science.gov (United States)

Yu, Zeta Tak For; Cheung, Mei Ki; Liu, Shirley Xiaosu; Fu, Jianping

2016-09-01

Rapid fluid transport and exchange are critical operations involved in many microfluidic applications. However, conventional mechanisms used for driving fluid transport in microfluidics, such as micropumping and high pressure, can be inaccurate and difficult for implementation for integrated microfluidics containing control components and closed compartments. Here, a technology has been developed termed Vacuum-Pressure Accelerated Movement (V-PAM) capable of significantly enhancing biofluid transport in complex microfluidic environments containing dead-end channels and closed chambers. Operation of the V-PAM entails a pressurized fluid loading into microfluidic channels where gas confined inside can rapidly be dissipated through permeation through a thin, gas-permeable membrane sandwiched between microfluidic channels and a network of vacuum channels. Effects of different structural and operational parameters of the V-PAM for promoting fluid filling in microfluidic environments have been studied systematically. This work further demonstrates the applicability of V-PAM for rapid filling of temperature-sensitive hydrogels and unprocessed whole blood into complex irregular microfluidic networks such as microfluidic leaf venation patterns and blood circulatory systems. Together, the V-PAM technology provides a promising generic microfluidic tool for advanced fluid control and transport in integrated microfluidics for different microfluidic diagnosis, organs-on-chips, and biomimetic studies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Materials for microfluidic chip fabrication.

Science.gov (United States)

Ren, Kangning; Zhou, Jianhua; Wu, Hongkai

2013-11-19

Through manipulating fluids using microfabricated channel and chamber structures, microfluidics is a powerful tool to realize high sensitive, high speed, high throughput, and low cost analysis. In addition, the method can establish a well-controlled microenivroment for manipulating fluids and particles. It also has rapid growing implementations in both sophisticated chemical/biological analysis and low-cost point-of-care assays. Some unique phenomena emerge at the micrometer scale. For example, reactions are completed in a shorter amount of time as the travel distances of mass and heat are relatively small; the flows are usually laminar; and the capillary effect becomes dominant owing to large surface-to-volume ratios. In the meantime, the surface properties of the device material are greatly amplified, which can lead to either unique functions or problems that we would not encounter at the macroscale. Also, each material inherently corresponds with specific microfabrication strategies and certain native properties of the device. Therefore, the material for making the device plays a dominating role in microfluidic technologies. In this Account, we address the evolution of materials used for fabricating microfluidic chips, and discuss the application-oriented pros and cons of different materials. This Account generally follows the order of the materials introduced to microfluidics. Glass and silicon, the first generation microfluidic device materials, are perfect for capillary electrophoresis and solvent-involved applications but expensive for microfabriaction. Elastomers enable low-cost rapid prototyping and high density integration of valves on chip, allowing complicated and parallel fluid manipulation and in-channel cell culture. Plastics, as competitive alternatives to elastomers, are also rapid and inexpensive to microfabricate. Their broad variety provides flexible choices for different needs. For example, some thermosets support in-situ fabrication of

Ultrasmall volume molecular isothermal amplification in microfluidic chip with advanced surface processing

International Nuclear Information System (INIS)

Huang Guoliang; Yang Xiaoyong; Ma Li; Yang Xu

2011-01-01

In this paper, we developed a metal micro-fluidic chip with advanced surface processing for ultra-small volume molecular isothermal amplification. This method takes advantages of the nucleic acid amplification with good stability and consistency, high sensitivity about 31 genomic DNA copies and bacteria specific gene identification. Based on the advanced surface processing, the bioreaction assays of nucleic acid amplification was dropped about 392nl in volume. A high numerical aperture confocal optical detection system was advanced to sensitively monitor the DNA amplification with low noise and high power collecting fluorescence near to the optical diffraction limit. A speedy nucleic acid isothermal amplification was performed in the ultra-small volume microfluidic chip, where the time at the inflexions of second derivative to DNA exponential amplified curves was brought forward and the sensitivity was improved about 65 folds to that of in current 25μl Ep-tube amplified reaction, which indicates a promising clinic molecular diagnostics in the droplet amplification.

Quartz fiber calorimeter

International Nuclear Information System (INIS)

Akchurin, N.; Doulas, S.; Ganel, O.; Gershtein, Y.; Gavrilov, V.; Kolosov, V.; Kuleshov, S.; Litvinsev, D.; Merlo, J.-P.; Onel, Y.; Osborne, D.; Rosowsky, A.; Stolin, V.; Sulak, L.; Sullivan, J.; Ulyanov, A.; Wigmans, R.; Winn, D.

1996-01-01

A calorimeter with optical quartz fibers embedded into an absorber matrix was proposed for the small angle region of the CMS detector at LHC (CERN). This type of calorimeter is expected to be radiation hard and to produce extremely fast signal. Some results from beam tests of the quartz fiber calorimeter prototype are presented. (orig.)

The high-voltage monitor system for the calorimeter of the OBELIX experiment

International Nuclear Information System (INIS)

Bertin, A.; Bruschi, M.; Capponi, M.; Cereda, B.; D'Antone, I.; De Castro, S.; Galli, D.; Giacobbe, B.; Marconi, U.; Massa, I.; Piccinini, M.; Poli, M.; Semprini-Cesari, N.; Spighi, R.; Vecchi, S.; Vezzani, A.; Villa, M.; Vitale, A.; Zoccoli, A.

1993-01-01

We describe the monitor system developed to manage the high voltage power supply for the electromagnetic calorimeter of the OBELIX experiment, installed on the LEAR facility at CERN. The hardware and software characteristics of the system are discussed, as well as the performance of the same. (orig.)

A high-temperature high-pressure calorimeter for determining heats of solution up to 623 K.

Science.gov (United States)

Djamali, Essmaiil; Turner, Peter J; Murray, Richard C; Cobble, James W

2010-07-01

A high-temperature high-pressure isoperibol calorimeter for determining the heats of solution and reaction of very dilute substances in water (10(-4) m) at temperatures up to 623 K is described. The energies of vaporization of water at steam saturation pressure were measured as a function of temperature and the results agree with the corresponding values from steam tables to better than 0.08+/-0.18%. The novelties of the present instrument relative to flow type heat capacity calorimeters are that measurements can be made at orders of magnitude lower concentrations and that measurement of heat of reaction involving solids or gases or in the presence of high concentrations of supporting electrolytes, acids, and bases is possible. Furthermore, the advantage of using enthalpy data over heat capacity data for calculations of the standard state Gibbs free energies of electrolytes is that the experimental heat data of this research need only be integrated once to derive higher temperature free energy data from lower temperatures. The derived heat capacities can be used mathematically to obtain free energies by double integration. However, the resulting errors are much smaller than if experimental aqueous heat capacities were used for the integrations.

Latest developments on the highly granular Silicon-Tungsten Electromagnetic Calorimeter technological prototype for the International Large Detector

CERN Document Server

Irles, Adrián

2017-01-01

High precision physics at future colliders requires unprecedented highly granular calorimeters for the application of the Particle Flow (PF) algorithm. The physical proof of concept was given in the previous campaign of beam tests of physic prototypes within the CALICE collaboration. We present here the latest beam and laboratory test results and R&D developments for the Silicon-Tungsten Electromagnetic Calorimeter technological prototype with fully embedded very front-end (VFE) electronics for the International Large Detector at the International Linear Collider project.

Spintronic microfluidic platform for biomedical and environmental applications

Science.gov (United States)

Cardoso, F. A.; Martins, V. C.; Fonseca, L. P.; Germano, J.; Sousa, L. A.; Piedade, M. S.; Freitas, P. P.

2010-09-01

Faster, more sensitive and easy to operate biosensing devices still are a need at important areas such as biomedical diagnostics, food control and environmental monitoring. Recently, spintronic-devices have emerged as a promising alternative to the existent technologies [1-3]. A number of advantages, namely high sensitivity, easy integration, miniaturization, scalability, robustness and low cost make these devices potentially capable of responding to the existent technological need. In parallel, the field of microfluidics has shown great advances [4]. Microfluidic systems allow the analysis of small sample volumes (from micro- down to pico-liters), often by automate sample processing with the ability to integrate several steps into a single device (analyte amplification, concentration, separation and/or labeling), all in a reduced assay time (minutes to hours) and affordable cost. The merging of these two technologies, magnetoresistive biochips and microfluidics, will enable the development of highly competitive devices. This work reports the integration of a magnetoresistive biochip with a microfluidic system inside a portable and autonomous electronic platform aiming for a fully integrated device. A microfluidic structure fabricated in polydimethylsiloxane with dimensions of W: 0.5mm, H: 0.1mm, L: 10mm, associated to a mechanical system to align and seal the channel by pressure is presented (Fig. 1) [5]. The goal is to perform sample loading and transportation over the chip and simultaneously control the stringency and uniformity of the wash-out process. The biochip output is acquired by an electronic microsystem incorporating the circuitry to control, address and read-out the 30 spin-valve sensors sequentially (Fig. 1) [2]. This platform is being applied to the detection of water-borne microbial pathogens (e.g. Salmonella and Escherichia coli) and genetic diseases diagnosis (e.g. cystic fibrosis) through DNA hybridization assays. Open chamber measurements were

LHCb: High Voltage system for the LHCb calorimeter detectors at CERN

CERN Multimedia

Konoplyannikov, A

2006-01-01

All calorimeters are equipped with Hamamatsu photo tubes as devices for light to signal conversion. Eight thousand R7899-20 tubes are used for the electromagnetic and hadronic calorimeters and two hundred 64 channels multi-anode R7600 -00-M64 for Scintillator-Pad/Preshower detectors. Similar photo-detectors are widely used in the Molecular Imaging applications.

Scintillator performance at low dose rates and low temperatures for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Ricci-Tam, Francesca

2018-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance, especially for forward calorimetry, and highlights the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. The upgrade includes both electromagnetic and hadronic components, with the latter using a mixture of silicon sensors (in the highest radiation regions at high pseudorapidity) and scintillator as its active components. The scintillator will nevertheless receive large doses accumulated at low dose rates, and will have to operate at low temperature - around -30 degrees Celsius. We discuss measurements of scintillator radiation tolerance, from in-situ measurements from the current CMS endcap calorimeters, and from measurements at low temperature and low dose-rate at gamma sources in the laboratory.

Proposal for Research and Development of a Hadron Calorimeter for High Magnetic Fields

CERN Multimedia

2002-01-01

RD43 : We intend to pursue the R\\&D necessary to demonstrate that a Cu-scintillator hadron calorimeter can operate reliably and well at the LHC at large pseudorapidities (\\mid $\\eta$\\mid~$\\leq$~2.6) and in a high magnetic field (4~T). The chosen technique consists of embedding a wavelength shifting (WLS) fibre in a scintillator plate in the form of a $\\sigma$. A clear fibre, spliced on to the WLS fibre, transports the shifted light to a photodetector. This technique was chosen by the SDC Collaboration for their electromagnetic and hadronic calorimetry. R\\&D efforts will concentrate on radiation tolerant scintillator/WLS combinations, transducers that can provide gain and operate in high magnetic fields, the effect on the performance of dead material (e.g. coil of~$\\leq$~1 $\\lambda $) placed after 5-7 $\\lambda $, the effect on performance of a high resolution electromagnetic calorimeter, the design of a hermetic mechanical structure, the issues of calibration and monitoring.

The H1 lead/scintillating-fibre calorimeter

International Nuclear Information System (INIS)

Appuhn, R.D.; Arndt, C.; Barrelet, E.

1996-08-01

The backward region of the H1 detector has been upgraded in order to provide improved measurement of the scattered electron in deep inelastic scattering events. The centerpiece of the upgrade is a high-resolution lead/scintillating-fibre calorimeter. The main design goals of the calorimeter are: good coverage of the region close to the beam pipe, high angular resolution and energy resolution of better than 2% for 30 GeV electrons. The calorimeter should be capable of providing coarse hadronic energy measurement and precise time information to suppress out-of-time background events at the first trigger level. It must be compact due to space restrictions. These requirements were fulfilled by constructing two separate calorimeter sections. The inner electromagnetic section is made of 0.5 mm scintillating plastic fibres embedded in a lead matrix. Its lead-to-fibre ratio is 2.3:1 by volume. The outer hadronic section consists of 1.0 mm diameter fibres with a lead-to-fibre ratio of 3.4:1. The mechanical construction of the new calorimeter and its assembly in the H1 detector are described. (orig.)

The H1 lead/scintillating-fibre calorimeter

International Nuclear Information System (INIS)

Appuhn, R.-D.; Arndt, C.; Barrelet, E.

1997-01-01

The backward region of the H1 detector has been upgraded in order to provide improved measurement of the scattered electron in deep inelastic scattering events. The centerpiece of the upgrade is a high-resolution lead/scintillating-fibre calorimeter. The main design goals of the calorimeter are: good coverage of the region close to the beam pipe, high angular resolution and energy resolution of better than 2% for 30 GeV electrons. The calorimeter should be capable of providing coarse hadronic energy measurement and precise time information to suppress out-of-time background events at the first trigger level. It must be compact due to space restrictions. These requirements were fulfilled by constructing two separate calorimeter sections. The inner electromagnetic section is made of 0.5 mm scintillating plastic fibres embedded in a lead matrix. Its lead-to-fibre ratio is 2.3:1 by volume. The outer hadronic section consists of 1.0 mm diameter fibres with a lead-to-fibre ratio of 3.4:1. The mechanical construction of the new calorimeter and its assembly in the H1 detector are described. (orig.)

The Scintillator Tile Hadronic Calorimeter Prototype

International Nuclear Information System (INIS)

Rusinov, V.

2006-01-01

A high granularity scintillator hadronic calorimeter prototype is described. The calorimeter is based on a novel photodetector - Silicon Photo-Multiplier (SiPM). The main parameters of SiPM are discussed as well as readout cell construction and optimization. The experience with a small prototype production and testing is described. A new 8 k channel prototype is being manufactured now

Peltier ac calorimeter

OpenAIRE

Jung, D. H.; Moon, I. K.; Jeong, Y. H.

2001-01-01

A new ac calorimeter, utilizing the Peltier effect of a thermocouple junction as an ac power source, is described. This Peltier ac calorimeter allows to measure the absolute value of heat capacity of small solid samples with sub-milligrams of mass. The calorimeter can also be used as a dynamic one with a dynamic range of several decades at low frequencies.

Shower fractal dimension analysis in a highly-granular calorimeter

CERN Document Server

Ruan, M

2014-01-01

We report on an investigation of the self-similar structure of particle showers recorded at a highly-granular calorimeter. On both simulated and experimental data, a strong correlation between the number of hits and the spatial scale of the readout channels is observed, from which we define the shower fractal dimension. The measured fractal dimension turns out to be strongly dependent on particle type, which enables new approaches for particle identification. A logarithmic dependence of the particle energy on the fractal dimension is also observed.

Run 1 Performance of the ATLAS Tile Calorimeter

CERN Document Server

Heelan, Louise; The ATLAS collaboration

2014-01-01

The ATLAS Tile hadronic calorimeter (TileCal) provides highly-segmented energy measurements of incoming particles. It is a key detector for the measurement of hadrons, jets, tau leptons and missing transverse energy. It is also useful for identification and reconstruction of muons due to good signal to noise ratio. The calorimeter consists of thin steel plates and 460,000 scintillating tiles configured into 5000 cells, each viewed by two photomultipliers. The calorimeter response and its readout electronics is monitored to better than 1% using radioactive source, laser and charge injection systems. The calibration and performance of the calorimeter have been established through test beam measurements, cosmic ray muons and the large sample of proton-proton collisions acquired in 2011 and 2012. Results on the calorimeter performance are presented, including the absolute energy scale, timing, noise and associated stabilities. The results demonstrate that the Tile Calorimeter has performed well within the design ...

Calibration of Tilecal hadronic calorimeter of the ATLAS

International Nuclear Information System (INIS)

Batkova, L.

2009-01-01

The aim of a precise calibration of a calorimeter is to get the best response relationship between the calorimeter and the energy of incident particles. Different types of particles interact through various types of interactions with the environment. Therefore, calorimeters are optimized to detect one type of particle (electromagnetic particles and hadrons). Within current high energy physics experiments, where the detectors reached gigantic proportions, calorimeters hold two important features: - serve to measure power showers by complete absorption method; - reconstruct a direction of showers of particles after their interaction with the environment of calorimeter. To deterioration of the resolving power of the hadronic calorimeter contributes incompensation of its response to hadrons and electromagnetic particles (e, μ). They record more energy from electrons as from pions of the same nominal power. During building of experiment of the ATLAS the prototypes of Tile calorimeter were calibrated using Cs and then were tested by means of calibration particle beams (e, μ, π). The work is aimed to evaluation of the response of the muon beam calibration experiment ATLAS. The scope of the work is to determine correction factors for the calibration constants obtained from the primary calibration of the calorimeter by cesium for end Tilecal calorimeter modules. Tile calorimeter modules consist of three layers A, BC and D. A correction factor for calibration constant for A layer was determined by electron beam firing angle less than 20 grad. Muons are used to determine correction factors for the remaining two layers of the end calorimeter module, where the electrons of given energy do not penetrate. (author)

Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter

Czech Academy of Sciences Publication Activity Database

Eigen, G.; Price, T.; Watson, N.K.; Cvach, Jaroslav; Gallus, Petr; Havránek, Miroslav; Janata, Milan; Lednický, Denis; Marčišovský, Michal; Polák, Ivo; Popule, Jiří; Tomášek, Lukáš; Tomášek, Michal; Šícho, Petr; Smolík, Jan; Vrba, Václav; Zálešák, Jaroslav

2016-01-01

Roč. 11, Jul (2016), 1-37, č. článku P06013. ISSN 1748-0221 R&D Projects: GA MŠk LG14033; GA MŠk 7E12050 Institutional support: RVO:68378271 Keywords : hadron shower s * scintillator calorimeters * simulation of shower s Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.220, year: 2016

Fundamentals of microfluidics for high school students with no prior knowledge of fluid mechanics.

Science.gov (United States)

Tandon, Vishal; Peck, Walter

2013-01-01

Three microfluidics-based laboratory exercises were developed and implemented in a high school science classroom setting. The first exercise demonstrated ways in which flows are characterized, including viscosity, turbulence, shear stress, reversibility, compressibility, and hydrodynamic resistance. Students characterized flows in poly(dimethylsiloxane) microfluidic devices in the other two exercises, where they observed the mixing characteristics of laminar flows, and conservation of volumetric flow rate for incompressible flows. In surveys, the students self-reported increased knowledge of microfluidics, and an improved attitude toward science and nanotechnology.

The CHORUS calorimeter: test results

International Nuclear Information System (INIS)

Buontempo, S.; Capone, A.; Cocco, A.G.; De Pedis, D.; Di Capua, E.; Dore, U.; Ereditato, A.; Ferroni, M.; Fiorillo, G.; Loverre, P.F.; Luppi, C.; Macina, D.; Mazzoni, M.A.; Migliozzi, P.; Palladino, V.; Piredda, G.; Riccardi, F.; Righini, P.P.; Saitta, B.; Santacesaria, R.; Strolin, P.; Zucchelli, P.

1995-01-01

In the framework of the CHORUS experiment for the search of ν μ ν τ oscillations at CERN, we have built the high resolution calorimeter, intended for the measurement of the energy of hadronic showers produced in neutrino interactions. The calorimeter consists of three parts. The first two are made of lead and plastic scintillating fibers in the volume ratio 4 : 1, such as to achieve compensation. The third is a sandwich of lead plates and scintillator strips in the same volume ratio. The techniques used for the construction of the calorimeter are described, as well as its performance in shower and muon detection. We used electron, pion and muon beams in the energy range 2-100 GeV for this purpose. (orig.)

Analytical characterization using surface-enhanced Raman scattering (SERS) and microfluidic sampling

International Nuclear Information System (INIS)

Wang, Chao; Yu, Chenxu

2015-01-01

With the rapid development of analytical techniques, it has become much easier to detect chemical and biological analytes, even at very low detection limits. In recent years, techniques based on vibrational spectroscopy, such as surface enhanced Raman spectroscopy (SERS), have been developed for non-destructive detection of pathogenic microorganisms. SERS is a highly sensitive analytical tool that can be used to characterize chemical and biological analytes interacting with SERS-active substrates. However, it has always been a challenge to obtain consistent and reproducible SERS spectroscopic results at complicated experimental conditions. Microfluidics, a tool for highly precise manipulation of small volume liquid samples, can be used to overcome the major drawbacks of SERS-based techniques. High reproducibility of SERS measurement could be obtained in continuous flow generated inside microfluidic devices. This article provides a thorough review of the principles, concepts and methods of SERS-microfluidic platforms, and the applications of such platforms in trace analysis of chemical and biological analytes. (topical review)

Fast Calorimeter Simulation in ATLAS

CERN Document Server

Schaarschmidt, Jana; The ATLAS collaboration

2017-01-01

Producing the very large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing CPU requirements when detailed detector simulations are not needed. During the LHC Run-1, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and it can be tuned to data more easily than GEANT4. It is 500 times faster than full simulation in the calorimeter system. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim makes use of mach...

The ZEUS uranium-scintillator calorimeter for HERA

International Nuclear Information System (INIS)

Hilger, E.

1987-01-01

The high resolution calorimeter for the ZEUS detector at HERA is presented. The choice of a sandwich calorimeter from depleted uranium plates and plastic scintillator was made to accomplish compensation and thus the best possible energy resolution for hadrons and jets. The calorimeter is segmented transversely into towers and longitudinally into an electromagnetic and one or two hadronic sections. It is divided in a forward, barrel and rear part which surround hermetically the interaction region and the inner detectors. The expected energy resolutions are for electrons σ(E)/E = 0.15/√E, and for hadrons σ(E)/E = 0.35/√E, with a constant term of maximum 2% added in quadrature. First results from calorimeter test measurements are presented. (orig.)

The ATLAS Liquid Argon Calorimeter: Construction, Integration, Commissioning

International Nuclear Information System (INIS)

Aleksa, Martin

2006-01-01

The ATLAS liquid argon (LAr) calorimeter system consists of an electromagnetic barrel calorimeter and two end caps with electromagnetic, hadronic and forward calorimeters. The liquid argon sampling technique, with an accordion geometry was chosen for the barrel electromagnetic calorimeter (EMB) and adapted to the end cap (EMEC). The hadronic end cap calorimeter (HEC) uses a copper-liquid argon sampling technique with flat plate geometry and is subdivided in depth in two wheels per end-cap. Finally, the forward calorimeter (FCAL) is composed of three modules employing cylindrical electrodes with thin liquid argon gaps.The construction of the full calorimeter system is complete since mid-2004. Production modules constructed in the home institutes were integrated into wheels at CERN in 2003-2004, and inserted into the three cryostats. They passed their first complete cold test before the lowering into the ATLAS cavern. Results of quality checks (e.g. electrical, mechanical, ...) performed on all the 190304 read-out channels after cool down will be reported. End 2004 the ATLAS barrel electromagnetic (EM) calorimeter was installed in the ATLAS cavern and since summer 2005 the front-end electronics are being connected and tested. Results of this first commissioning phase will be shown to demonstrate the high standards of quality control for our detectors

Performance of the ATLAS Tile Calorimeter

Science.gov (United States)

Hrynevich, A.

2017-06-01

The Tile Calorimeter (TileCal) is the central scintillator-steel sampling hadronic calorimeter of the ATLAS experiment at the LHC . Jointly with other calorimeters it is designed for energy reconstruction of hadrons, jets, tau-particles and missing transverse energy. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal frontend electronics reads out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV . Each stage of the signal production from scintillation light to the signal reconstruction is monitored and calibrated. The performance of the calorimeter has been established with cosmic ray muons and the large sample of the proton-proton collisions. The response of high momentum isolated muons is used to study the energy response at the electromagnetic scale, isolated hadrons are used as a probe of the hadronic response and its modelling by the Monte Carlo simulations. The calorimeter time resolution is studied with multijet events. Results on the calorimeter operation and performance are presented, including the calibration, stability, absolute energy scale, uniformity and time resolution. These results show that the TileCal performance is within the design requirements and has given essential contribution to reconstructed objects and physics results.

Hadron calorimeter towers with a high space resolution

International Nuclear Information System (INIS)

Bellettini, G.; Bertani, R.; Bradaschia, C.; Del Fabbro, R.; Scribano, A.; Terreni, G.

1982-01-01

The performances of a set of hadron calorimeter towers for measuring the hadron impact point are described. It is shown that an accuracy of 1-2 cm can be achieved with a proper treatment of the data. (orig.)

Top quark threshold scan and study of detectors for highly granular hadron calorimeters at future linear colliders

International Nuclear Information System (INIS)

Tesar, Michal

2014-01-01

Two major projects for future linear electron-positron colliders, the International Linear Collider (ILC) and the Compact Linear Collider (CLIC), are currently under development. These projects can be seen as complementary machines to the Large Hadron Collider (LHC) which permit a further progress in high energy physics research. They overlap considerably and share the same technological approaches. To meet the ambitious goals of precise measurements, new detector concepts like very finely segmented calorimeters are required. We study the precision of the top quark mass measurement achievable at CLIC and the ILC. The employed method was a t anti t pair production threshold scan. In this technique, simulated measurement points of the t anti t production cross section around the threshold are fitted with theoretical curves calculated at next-to-next-to-leading order. Detector effects, the influence of the beam energy spectrum and initial state radiation of the colliding particles are taken into account. Assuming total integrated luminosity of 100 fb -1 , our results show that the top quark mass in a theoretically well-defined 1S mass scheme can be extracted with a combined statistical and systematic uncertainty of less than 50 MeV. The other part of this work regards experimental studies of highly granular hadron calorimeter (HCAL) elements. To meet the required high jet energy resolution at the future linear colliders, a large and finely segmented detector is needed. One option is to assemble a sandwich calorimeter out of many low-cost scintillators read out by silicon photomultipliers (SiPM). We characterize the areal homogeneity of SiPM response with the help of a highly collimated beam of pulsed visible light. The spatial resolution of the experiment reach the order of 1 μm and allows to study the active area structures within single SiPM microcells. Several SiPM models are characterized in terms of relative photon detection efficiency and probability crosstalk

Study of a novel electromagnetic liquid argon calorimeter TGT

International Nuclear Information System (INIS)

Berger, C.; Braunschweig, W.; Geulig, E.

1994-01-01

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a test beam exposure. 15 refs., 16 figs., 2 tabs

Development of a semi-adiabatic isoperibol solution calorimeter.

Science.gov (United States)

Venkata Krishnan, R; Jogeswararao, G; Parthasarathy, R; Premalatha, S; Prabhakar Rao, J; Gunasekaran, G; Ananthasivan, K

2014-12-01

A semi-adiabatic isoperibol solution calorimeter has been indigenously developed. The measurement system comprises modules for sensitive temperature measurement probe, signal processing, data collection, and joule calibration. The sensitivity of the temperature measurement module was enhanced by using a sensitive thermistor coupled with a lock-in amplifier based signal processor. A microcontroller coordinates the operation and control of these modules. The latter in turn is controlled through personal computer (PC) based custom made software developed with LabView. An innovative summing amplifier concept was used to cancel out the base resistance of the thermistor. The latter was placed in the dewar. The temperature calibration was carried out with a standard platinum resistance (PT100) sensor coupled with an 8½ digit multimeter. The water equivalent of this calorimeter was determined by using electrical calibration with the joule calibrator. The experimentally measured values of the quantum of heat were validated by measuring heats of dissolution of pure KCl (for endotherm) and tris (hydroxyl methyl) amino-methane (for exotherm). The uncertainity in the measurements was found to be within ±3%.

Development of a semi-adiabatic isoperibol solution calorimeter

International Nuclear Information System (INIS)

Venkata Krishnan, R.; Jogeswararao, G.; Parthasarathy, R.; Premalatha, S.; Prabhakar Rao, J.; Gunasekaran, G.; Ananthasivan, K.

2014-01-01

A semi-adiabatic isoperibol solution calorimeter has been indigenously developed. The measurement system comprises modules for sensitive temperature measurement probe, signal processing, data collection, and joule calibration. The sensitivity of the temperature measurement module was enhanced by using a sensitive thermistor coupled with a lock-in amplifier based signal processor. A microcontroller coordinates the operation and control of these modules. The latter in turn is controlled through personal computer (PC) based custom made software developed with LabView. An innovative summing amplifier concept was used to cancel out the base resistance of the thermistor. The latter was placed in the dewar. The temperature calibration was carried out with a standard platinum resistance (PT100) sensor coupled with an 8½ digit multimeter. The water equivalent of this calorimeter was determined by using electrical calibration with the joule calibrator. The experimentally measured values of the quantum of heat were validated by measuring heats of dissolution of pure KCl (for endotherm) and tris (hydroxyl methyl) amino-methane (for exotherm). The uncertainity in the measurements was found to be within ±3%

Development of a semi-adiabatic isoperibol solution calorimeter

Energy Technology Data Exchange (ETDEWEB)

Venkata Krishnan, R.; Jogeswararao, G.; Parthasarathy, R.; Premalatha, S.; Prabhakar Rao, J.; Gunasekaran, G.; Ananthasivan, K., E-mail: asivan@igcar.gov.in [Chemistry Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102, Tamilnadu (India)

2014-12-15

A semi-adiabatic isoperibol solution calorimeter has been indigenously developed. The measurement system comprises modules for sensitive temperature measurement probe, signal processing, data collection, and joule calibration. The sensitivity of the temperature measurement module was enhanced by using a sensitive thermistor coupled with a lock-in amplifier based signal processor. A microcontroller coordinates the operation and control of these modules. The latter in turn is controlled through personal computer (PC) based custom made software developed with LabView. An innovative summing amplifier concept was used to cancel out the base resistance of the thermistor. The latter was placed in the dewar. The temperature calibration was carried out with a standard platinum resistance (PT100) sensor coupled with an 8½ digit multimeter. The water equivalent of this calorimeter was determined by using electrical calibration with the joule calibrator. The experimentally measured values of the quantum of heat were validated by measuring heats of dissolution of pure KCl (for endotherm) and tris (hydroxyl methyl) amino-methane (for exotherm). The uncertainity in the measurements was found to be within ±3%.

Graphene nano-ink biosensor arrays on a microfluidic paper for multiplexed detection of metabolites

Energy Technology Data Exchange (ETDEWEB)

Labroo, Pratima; Cui, Yue, E-mail: yue.cui@usu.edu

2014-02-01

Graphical abstract: - Highlights: • We report graphene-ink biosensor arrays on a microfluidic paper for metabolites. • The device is able to detect multiple metabolites sensitively and rapidly. • The device fabrication process is simple and inexpensive. - Abstract: The development of a miniaturized and low-cost platform for the highly sensitive, selective and rapid detection of multiplexed metabolites is of great interest for healthcare, pharmaceuticals, food science, and environmental monitoring. Graphene is a delicate single-layer, two-dimensional network of carbon atoms with extraordinary electrical sensing capability. Microfluidic paper with printing technique is a low cost matrix. Here, we demonstrated the development of graphene-ink based biosensor arrays on a microfluidic paper for the multiplexed detection of different metabolites, such as glucose, lactate, xanthine and cholesterol. Our results show that the graphene biosensor arrays can detect multiple metabolites on a microfluidic paper sensitively, rapidly and simultaneously. The device exhibits a fast measuring time of less than 2 min, a low detection limit of 0.3 μM, and a dynamic detection range of 0.3–15 μM. The process is simple and inexpensive to operate and requires a low consumption of sample volume. We anticipate that these results could open exciting opportunities for a variety of applications.

Radiation hardness and precision timing study of Silicon detectors for the CMS High Granularity Calorimeter (HGC)

CERN Document Server

Curras, E; Gallrapp, C; Gray, L; Mannelli, M; Meridiani, P; Moll, M; Nourbakhsh, S; Scharf, C; Silva, P; Steinbrueck, G; Tabarelli de Fatis, T; Vila, I

2017-01-01

The high luminosity upgraded LHC or Phase-II is expected to increase the instantaneous luminosity by a factor of 10 beyond the LHC's design value, expecting to deliver 250 fb^−1 per year for a further 10 years of operation. Under these conditions the performance degradation due to integrated radiation dose will need to be addressed. The CMS collaboration is planning to upgrade the forward calorimeters. The replacement is called the High Granularity Calorimeter (HGC) and it will be realized as a sampling calorimeter with layers of silicon detectors interleaved. The sensors will be realized as pad detectors with sizes of less that ∼1.0 cm^2 and an active thickness between 100 and 300 μm depending on the position, respectively, the expected radiation levels. For an integrated luminosity of 3000 fb^−1, the electromagnetic calorimetry will sustain integrated doses of 1.5 MGy (150 Mrads) and neutron fluences up to 10^16 neq/cm^2. A radiation tolerance study after neutron irradiation of 300, 200, and 100 μ...

CrossRef Energy Reconstruction in a High Granularity Semi-Digital Hadronic Calorimeter for ILC Experiments

CERN Document Server

Mannai, S; Cortina, E; Laktineh, I

2016-01-01

Abstract: The Semi-Digital Hadronic CALorimeter (SDHCAL) is one of the two hadronic calorimeter options proposed by the International Large Detector (ILD) project for the future International Linear Collider (ILC) experiments. It is a sampling calorimeter with 48 active layers made of Glass Resistive Plate Chambers (GRPCs) and their embedded electronics. A fine lateral segmentation is obtained thanks to pickup pads of 1 cm2. This ensures the high granularity required for the application of the Particle Flow Algorithm (PFA) in order to improve the jet energy resolution in the ILC experiments. The performance of the SDHCAL technological prototype was tested successfully in several beam tests at CERN. The main point to be discussed here concerns the energy reconstruction in SDHCAL. Based on Monte Carlo simulation of the SDHCAL prototype using the GEANT4 package, we present different energy reconstruction methods to study the energy linearity and resolution of the detector response to single hadrons. In particula...

Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment

Science.gov (United States)

Chen, Q. L.; Ho, H. P.; Jin, L.; Chu, B. W.-K.; Li, M. J.; Yam, V. W.-W.

2008-02-01

This work primarily aims to integrate dissolved oxygen sensing capability with a microfluidic platform containing arrays of micro bio-reactors or bio-activity indicators. The measurement of oxygen concentration is of significance for a variety of bio-related applications such as cell culture and gene expression. Optical oxygen sensors based on luminescence quenching are gaining much interest in light of their low power consumption, quick response and high analyte sensitivity in comparison to similar oxygen sensing devices. In our microfluidic oxygen sensor device, a thin layer of oxygen-sensitive luminescent organometallic dye is covalently bonded to a glass slide. Micro flow channels are formed on the glass slide using patterned PDMS (Polydimethylsiloxane). Dissolved oxygen sensing is then performed by directing an optical excitation probe beam to the area of interest within the microfluidic channel. The covalent bonding approach for sensor layer formation offers many distinct advantages over the physical entrapment method including minimizing dye leaching, ensuring good stability and fabrication simplicity. Experimental results confirm the feasibility of the device.

Towards sensitive, high-throughput, biomolecular assays based on fluorescence lifetime

Science.gov (United States)

Ioanna Skilitsi, Anastasia; Turko, Timothé; Cianfarani, Damien; Barre, Sophie; Uhring, Wilfried; Hassiepen, Ulrich; Léonard, Jérémie

2017-09-01

Time-resolved fluorescence detection for robust sensing of biomolecular interactions is developed by implementing time-correlated single photon counting in high-throughput conditions. Droplet microfluidics is used as a promising platform for the very fast handling of low-volume samples. We illustrate the potential of this very sensitive and cost-effective technology in the context of an enzymatic activity assay based on fluorescently-labeled biomolecules. Fluorescence lifetime detection by time-correlated single photon counting is shown to enable reliable discrimination between positive and negative control samples at a throughput as high as several hundred samples per second.

The new ATLAS Fast Calorimeter Simulation

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00223142; The ATLAS collaboration

2016-01-01

Many physics and performance studies with the ATLAS detector at the Large Hadron Collider require very large samples of simulated events, and producing these using the full GEANT4 detector simulation is highly CPU intensive. Often, a very detailed detector simulation is not needed, and in these cases fast simulation tools can be used to reduce the calorimeter simulation time by a few orders of magnitude. The new ATLAS Fast Calorimeter Simulation (FastCaloSim) is an improved parametrisation compared to the one used in the LHC Run-1. It provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and can be tuned to data more easily than with GEANT4. The new FastCaloSim incorporates developments in geometry and physics lists of the last five years and benefit...

The new ATLAS Fast Calorimeter Simulation

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00176100; The ATLAS collaboration

2016-01-01

The physics and performance studies of the ATLAS detector at the Large Hadron Collider re- quire a large number of simulated events. A GEANT4 based detailed simulation of the ATLAS calorimeter systems is highly CPU intensive and such resolution is often unnecessary. To reduce the calorimeter simulation time by a few orders of magnitude, fast simulation tools have been developed. The Fast Calorimeter Simulation (FastCaloSim) provides a parameterised simulation of the particle energy response at the calorimeter read-out cell level. In Run 1, about 13 billion events were simulated in ATLAS, out of which 50% were produced using fast simulation. For Run 2, a new parameterisation is being developed to improve the original version: it incorporates developments in geometry and physics lists during the last five years and benefits from the knowledge acquired from the Run 1 data. The algorithm uses machine learning techniques to improve the parameterisations and to optimise the amount of information to be stored in the...

Performance of the ATLAS Tile Calorimeter

CERN Document Server

Hrynevich, Aliaksei; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) is the central scintillator-steel sampling hadronic calorimeter of the ATLAS experiment at the LHC. Jointly with other calorimeters it is designed for energy reconstruction of hadrons, jets, tau-particles and missing transverse energy. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal frontend electronics reads out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV. Each stage of the signal production from scintillation light to the signal reconstruction is monitored and calibrated. The performance of the calorimeter has been established with cosmic ray muons and the large sample of the proton-proton collisions. The response of high momentum isolated muons is used to study the energy response at the electromagnetic scale, isolated hadr...

Upgrading the ATLAS Fast Calorimeter Simulation

CERN Document Server

Hubacek, Zdenek; The ATLAS collaboration

2016-01-01

Many physics and performance studies with the ATLAS detector at the Large Hadron Collider require very large samples of simulated events, and producing these using the full GEANT4 detector simulation is highly CPU intensive. Often, a very detailed detector simulation is not needed, and in these cases fast simulation tools can be used to reduce the calorimeter simulation time by a few orders of magnitude. In ATLAS, a fast simulation of the calorimeter systems was developed, called Fast Calorimeter Simulation (FastCaloSim). It provides a parametrized simulation of the particle energy response at the calorimeter read-out cell level. It is interfaced to the standard ATLAS digitization and reconstruction software, and can be tuned to data more easily than with GEANT4. The original version of FastCaloSim has been very important in the LHC Run-1, with several billion events simulated. An improved parametrisation is being developed, to eventually address shortcomings of the original version. It incorporates developme...

The new ATLAS Fast Calorimeter Simulation

CERN Document Server

Dias, Flavia; The ATLAS collaboration

2016-01-01

A very large number of simulated events is required for physics and performance studies with the ATLAS detector at the Large Hadron Collider. Producing these with the full GEANT4 detector simulation is highly CPU intensive. As a very detailed detector simulation is not always required, fast simulation tools have been developed to reduce the calorimeter simulation time by a few orders of magnitude. The fast simulation of ATLAS for the calorimeter systems used in Run 1, called Fast Calorimeter Simulation (FastCaloSim), provides a parameterized simulation of the particle energy response at the calorimeter read-out cell level. It is then interfaced to the ATLAS digitization and reconstruction software. In Run 1, about 13 billion events were simulated in ATLAS, out of which 50% were produced using fast simulation. For Run 2, a new parameterisation is being developed to improve the original version: It incorporates developments in geometry and physics lists of the last five years and benefits from knowledge acquire...

Signal processing for high granularity calorimeter: amplification, filtering, memorization and digitalization

Energy Technology Data Exchange (ETDEWEB)

Royer, L; Manen, S; Gay, P, E-mail: royer@clermont.in2p3.f [Clermont Universite, Universite Blaise Pascal, CNRS/IN2P3, LPC, BP 10448, F-63000 Clermont-Ferrand (France)

2010-12-15

A very-front-end electronics dedicated to high granularity calorimeters has been designed and its performance measured. This electronics performs the amplification of the charge delivered by the detector thanks to a low-noise Charge Sensitive Amplifier. The dynamic range is improved using a bandpass filter based on a Gated Integrator. Studying its weighting function, we show that this filter is more efficient than standard CRRC shaper, thanks to the integration time which can be expand near the bunch interval time, whereas the peaking time of the CRRC shaper is limited to pile-up consideration. Moreover, the Gated Integrator performs intrinsically the analog memorization of the signal before its delayed digital conversion. The analog-to-digital conversion is performed through a 12-bit cyclic ADC specifically developed for this application. The very-front-end channel has been fabricated using a 0.35 {mu}m CMOS technology. Measurements show a global non-linearity better than 0.1%. The Equivalent Noise Charge at the input of the channel is evaluated to 1.8 fC, compare to the maximum input charge of 10 pC. The power consumption of the complete channel is limited to 6.5 mW.

Space resolution obtained with a highly segmented SCIFI e.m. calorimeter

International Nuclear Information System (INIS)

De Zorzi, G.; Bertino, M.; Bini, C.; De Pedis, D.; Diambrini Palazzi, G.; Di Cosimo, G.; Di Domenico, A.; Gauzzi, P.; Zanello, D.

1992-01-01

During the setting up of the LEP-5 experiment, we tested a longitudinal SCIFI e.m. calorimeter, having a module cross area 25x25 mm 2 and 12.5x12.5 mm 2 for large and small modules respectively. The results were obtained with 10 and 50 GeV electrons, and concern the impact point resolution and the transverse distribution of the e.m. shower energy inside the calorimeter. (orig.)

The spaghetti calorimeter. Research, development, application

Energy Technology Data Exchange (ETDEWEB)

Scheel, C V

1994-12-22

The Spaghetti Calorimeter (SPACAL) is a detector intended primarily for the energy measurement of high-energy particles, but also provides spatial information and particle identification. It is a sampling calorimeter composed of plastic scintillating fibers, oriented in the direction of the particle, embedded in lead. The scintillation light is read out by photomultipliers, which are coupled to bunches of fibers through light guides, each forming a tower. It was developed as an electromagnetic (e.m.) and compensating hadronic calorimeter for use in future multi-TeV collider experiments. The largest prototype was installed for an alternative application as an hadronic calorimeter in the WA89 experiment, where it is used for the detection of neutrons resulting from {Sigma} decays. The basic concepts behind calorimetry are discussed in detail. Several prototypes were tested in beams of electrons and pions with energies up to 150 GeV. Resonable e.m. energy resolution, at {sigma}/E=12.9%/{radical}E[GeV]+1.23%, was measured. Excellent hadronic energy resolution was found, at 30.6%/{radical}E[GeV]+1.0%, but the calorimeter was found to be slightly undercompensating with e/h=1.15. The position of the shower barycenter for both electrons and pions was easily found according to the relative energy deposits in the calorimeter towers. The calorimeter was also found to be able to provide effective discrimination between electrons and hadrons. The performance of SPACAL in the WA89 experiment at the Omega spectrometer at CERN was studied with the reconstruction of beam {Sigma}{sup -}particles via its decay {Sigma}{sup -}{yields}n{pi}{sup -}. Details of the calibration of SPACAL with electrons and protons are presented. (orig.).

The spaghetti calorimeter. Research, development, application

International Nuclear Information System (INIS)

Scheel, C.V.

1994-01-01

The Spaghetti Calorimeter (SPACAL) is a detector intended primarily for the energy measurement of high-energy particles, but also provides spatial information and particle identification. It is a sampling calorimeter composed of plastic scintillating fibers, oriented in the direction of the particle, embedded in lead. The scintillation light is read out by photomultipliers, which are coupled to bunches of fibers through light guides, each forming a tower. It was developed as an electromagnetic (e.m.) and compensating hadronic calorimeter for use in future multi-TeV collider experiments. The largest prototype was installed for an alternative application as an hadronic calorimeter in the WA89 experiment, where it is used for the detection of neutrons resulting from Σ decays. The basic concepts behind calorimetry are discussed in detail. Several prototypes were tested in beams of electrons and pions with energies up to 150 GeV. Resonable e.m. energy resolution, at σ/E=12.9%/√E[GeV]+1.23%, was measured. Excellent hadronic energy resolution was found, at 30.6%/√E[GeV]+1.0%, but the calorimeter was found to be slightly undercompensating with e/h=1.15. The position of the shower barycenter for both electrons and pions was easily found according to the relative energy deposits in the calorimeter towers. The calorimeter was also found to be able to provide effective discrimination between electrons and hadrons. The performance of SPACAL in the WA89 experiment at the Omega spectrometer at CERN was studied with the reconstruction of beam Σ - particles via its decay Σ - →nπ - . Details of the calibration of SPACAL with electrons and protons are presented. (orig.)

Microfluidic sensor for ultra high redox cycling amplification for highly selective electrochemical measurements

NARCIS (Netherlands)

Odijk, Mathieu; Straver, Martin; Olthuis, Wouter; van den Berg, Albert

2011-01-01

In this contribution a SU8/glass-based microfluidic sensor is described with two closely spaced parallel electrodes for highly selective measurements using the redox cycling (RC) effect. Using this sensor, a RC amplification of ~2000x is measured using the ferrocyanide redox couple, which is much

Calibration and performance of the CHORUS calorimeter

International Nuclear Information System (INIS)

Buontempo, S.; Capone, A.; Cocco, A.G.; De Pedis, D.; Di Capua, E.; Dore, U.; Ereditato, A.; Ferroni, M.; Fiorillo, G.; Loverre, P.F.; Luppi, C.; Macina, D.; Marchetti-Stasi, F.; Mazzoni, M.A.; Migliozzi, P.; Palladino, V.; Piredda, G.; Ricciardi, S.; Righini, P.P.; Saitta, B.; Santacesaria, R.; Strolin, P.; Zucchelli, P.

1995-01-01

A high resolution calorimeter has been built for CHORUS, an experiment which searches for ν μ →ν τ oscillation in the CERN neutrino beam. Aim of the calorimeter is to measure the energy and direction of hadronic showers produced in interactions of the neutrinos in a nuclear emulsion target and to track through-going muons. It is a longitudinally segmented sampling device made of lead and scintillating fibers or strips. This detector has been exposed to beams of pions and electrons of defined momentum for calibration. The method used for energy calibration and results on the calorimeter performance are reported. (orig.)

Study of response nonuniformity for the LHCb calorimeter module and the prototype of the CBM calorimeter module

International Nuclear Information System (INIS)

Korolko, I. E.; Prokudin, M. S.

2009-01-01

A spatial nonuniformity of the response to high-energy muons is studied in the modules of the LHCb electromagnetic calorimeter and the prototype of the calorimeter module with lead plates and scintillator tiles 0.5 mm thick. The nonuniformity of the response of the inner LHCb modules to 50-GeV electrons is also measured. Software is developed for a thorough simulation of light collection in scintillator plates of a shashlik calorimeter. A model is elaborated to describe light transmission from the initial scintillation to the wavelength-shifting fiber with a subsequent reradiation and propagation of light over the fiber to the photodetector. The results of the simulation are in good agreement with data.

The optical instrumentation of the ATLAS Tile Calorimeter

Czech Academy of Sciences Publication Activity Database

Abdallah, J.; Adragna, P.; Alexa, C.; Lokajíček, Miloš; Němeček, Stanislav; Přibyl, Lukáš

2013-01-01

Roč. 8, Jan (2013), P01005 ISSN 1748-0221 Institutional support: RVO:68378271 Keywords : calorimeters * calorimeter methods * scintillators * scintillation and light emission processes * solid, gas and liquid scintillators Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.526, year: 2013

Quantitative Determination of Nicotine in a PDMS Microfluidic Channel Using Surface Enhanced Raman Spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Jung, Jae Hyun; Choo, Jae Bum [Hanyang University, Ansan (Korea, Republic of); Kim, Duck Joong [Dankook University, Cheonan (Korea, Republic of); Lee, Sang Hoon [Korea University, Seoul (Korea, Republic of)

2006-02-15

Rapid and highly sensitive determination of nicotine in a PDMS microfluidic channel was investigated using surface enhanced Raman spectroscopy (SERS). A three-dimensional PDMS microfluidic channel was fabricated for this purpose. This channel shows a high mixing efficiency because the transverse and vertical dispersions of the fluid occur simultaneously through the upper and lower zig zag-type blocks. A higher efficiency of mixing could also be obtained by splitting each of the confluent streams into two sub-streams that then joined and recombined. The SERS signal was measured after nicotine molecules were effectively adsorbed onto silver nanoparticles by passing through the three-dimensional channel. A quantitative analysis of nicotine was performed based on the measured peak area at 1030 cm{sup -1}. The detection limit was estimated to be below 0.1 ppm. In this work, the SERS detection, in combination with a PDMS microfluidic channel, has been applied to the quantitative analysis of nicotine in aqueous solution. Compared to the other conventional analytical methods, the detection sensitivity was enhanced up to several orders of magnitude.

Performance of the ATLAS Hadronic Tile Calorimeter in Run-2 and its Upgrade for the High Luminosity LHC

CERN Document Server

Solovyanov, Oleg; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for energy reconstruction of hadrons, jets, tau-particles and missing transverse energy. TileCal is a scintillator-steel sampling calorimeter and it covers the region of pseudorapidity < 1.7. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal frontend electronics reads out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV. Each stage of the signal production from scintillation light to the signal reconstruction is monitored and calibrated. The performance of the Tile calorimeter has been studied in-situ employing cosmic ray muons and a large sample of proton-proton collisions acquired during the operations of the LHC. Prompt isolated muons of high moment...

Physics and Applications of Metallic Magnetic Calorimeters

Science.gov (United States)

Kempf, S.; Fleischmann, A.; Gastaldo, L.; Enss, C.

2018-03-01

Metallic magnetic calorimeters (MMCs) are calorimetric low-temperature particle detectors that are currently strongly advancing the state of the art in energy-dispersive single particle detection. They are typically operated at temperatures below 100 mK and make use of a metallic, paramagnetic temperature sensor to transduce the temperature rise of the detector upon the absorption of an energetic particle into a change of magnetic flux which is sensed by a superconducting quantum interference device. This outstanding interplay between a high-sensitivity thermometer and a near quantum-limited amplifier results in a very fast signal rise time, an excellent energy resolution, a large dynamic range, a quantum efficiency close to 100% as well as an almost ideal linear detector response. For this reason, a growing number of groups located all over the world is developing MMC arrays of various sizes which are routinely used in a variety of applications. Within this paper, we briefly review the state of the art of metallic magnetic calorimeters. This includes a discussion of the detection principle, sensor materials and detector geometries, readout concepts, the structure of modern detectors as well as the state-of-the-art detector performance.

Investigation of Kinetic Hydrate Inhibition Using a High Pressure Micro Differential Scanning Calorimeter

DEFF Research Database (Denmark)

Daraboina, Nagu; Malmos, Christine; von Solms, Nicolas

2013-01-01

of hydrate growth. Additionally, hydrate formed in the presence of inhibitor decomposed at higher temperatures compared to pure water, indicating that while hydrate formation is initially inhibited; once hydrates form, they are more stable in the presence of inhibitor. Overall, this method proved a viable......Methane hydrate formation and decomposition were investigated in the presence of the kinetic inhibitor (Luvicap EG) and synergist (polyethylene oxide; PEO) using a high pressure micro-differential scanning calorimeter (HP-μDSC) with both temperature ramping and isothermal temperature programs....... These investigations were performed using small samples in four different capillary tubes in the calorimeter cell. When the isothermal method was employed, it was found that Luvicap EG significantly delays the hydrate nucleation time as compared to water. The results obtained from the ramping method demonstrated...

International workshop on calorimeter simulation

International Nuclear Information System (INIS)

Filges, D.; Cloth, P.

1988-10-01

The aim of the Juelich workshop was to provide an overview of the state of calorimeter simulation and the methods used. This resulted in 29 contributions to the following topics: Code systems relevant to calorimeter simulation, vectorization and code speed-up, simulation of calorimeter experiments, special applications of calorimeter simulation. This report presents the viewgraphs of the given talks. (orig./HSI)

Study of a novel electromagnetic liquid argon calorimeter - the TGT

Energy Technology Data Exchange (ETDEWEB)

Berger, C. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Braunschweig, W. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Geulig, E. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Schoentag, M. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Siedling, R. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Wlochal, M. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.; Putzer, A. [European Organization for Nuclear Research, Geneva (Switzerland); Wotschack, J. [European Organization for Nuclear Research, Geneva (Switzerland); Cheplakov, A. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Feshchenko, A. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Kazarinov, M. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Kukhtin, V. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Ladygin, E. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Obudovskij, V. [Joint Inst. for Nuclear Research, Dubna (Russian Federation); Geweniger, C. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Hanke, P. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Kluge, E.E. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Krause, J. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Schmidt, M. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Stenzel, H. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Tittel, K. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Wunsch, M. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Zerwas, D. [Heidelberg Univ. (Germany). Inst. fuer Hochenergiephysik; Bruncko, D. [Slovenska Akademia Vied, Kosice (Slovakia). Ustav Experimentalnej Fyziky; Jusko, A. [Slovenska Akademia Vied, Kosice (Slovakia). Ustav Experimentalnej Fyziky; Kocper, B.; RD33 Collaboration

1994-11-01

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a testbeam exposure. (orig.)

Study of a novel electromagnetic liquid argon calorimeter - the TGT

Energy Technology Data Exchange (ETDEWEB)

Berger, C.; Braunschweig, W.; Geulig, E. [Technische Hochschule Aachen (Germany). 1. Physikalisches Inst.] [and others

1995-04-21

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a testbeam exposure. ((orig.)).

Study of a novel electromagnetic liquid argon calorimeter - the TGT

International Nuclear Information System (INIS)

Berger, C.; Braunschweig, W.; Geulig, E.

1995-01-01

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a testbeam exposure. ((orig.))

Particle-Based Microfluidic Device for Providing High Magnetic Field Gradients

Science.gov (United States)

Lin, Adam Y. (Inventor); Wong, Tak S. (Inventor)

2013-01-01

A microfluidic device for manipulating particles in a fluid has a device body that defines a main channel therein, in which the main channel has an inlet and an outlet. The device body further defines a particulate diverting channel therein, the particulate diverting channel being in fluid connection with the main channel between the inlet and the outlet of the main channel and having a particulate outlet. The microfluidic device also has a plurality of microparticles arranged proximate or in the main channel between the inlet of the main channel and the fluid connection of the particulate diverting channel to the main channel. The plurality of microparticles each comprises a material in a composition thereof having a magnetic susceptibility suitable to cause concentration of magnetic field lines of an applied magnetic field while in operation. A microfluidic particle-manipulation system has a microfluidic particle-manipulation device and a magnet disposed proximate the microfluidic particle-manipulation device.

Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms

Directory of Open Access Journals (Sweden)

Kazunori Serita

2018-05-01

Full Text Available We present a nonlinear optical crystal (NLOC-based terahertz (THz microfluidic chip with a few arrays of split ring resonators (SRRs for ultra-trace and quantitative measurements of liquid solutions. The proposed chip operates on the basis of near-field coupling between the SRRs and a local emission of point like THz source that is generated in the process of optical rectification in NLOCs on a sub-wavelength scale. The liquid solutions flowing inside the microchannel modify the resonance frequency and peak attenuation in the THz transmission spectra. In contrast to conventional bio-sensing with far/near-field THz waves, our technique can be expected to compactify the chip design as well as realize high sensitive near-field measurement of liquid solutions without any high-power optical/THz source, near-field probes, and prisms. Using this chip, we have succeeded in observing the 31.8 fmol of ion concentration in actual amount of 318 pl water solutions from the shift of the resonance frequency. The technique opens the door to microanalysis of biological samples with THz waves and accelerates development of THz lab-on-chip devices.

Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms

Science.gov (United States)

Serita, Kazunori; Matsuda, Eiki; Okada, Kosuke; Murakami, Hironaru; Kawayama, Iwao; Tonouchi, Masayoshi

2018-05-01

We present a nonlinear optical crystal (NLOC)-based terahertz (THz) microfluidic chip with a few arrays of split ring resonators (SRRs) for ultra-trace and quantitative measurements of liquid solutions. The proposed chip operates on the basis of near-field coupling between the SRRs and a local emission of point like THz source that is generated in the process of optical rectification in NLOCs on a sub-wavelength scale. The liquid solutions flowing inside the microchannel modify the resonance frequency and peak attenuation in the THz transmission spectra. In contrast to conventional bio-sensing with far/near-field THz waves, our technique can be expected to compactify the chip design as well as realize high sensitive near-field measurement of liquid solutions without any high-power optical/THz source, near-field probes, and prisms. Using this chip, we have succeeded in observing the 31.8 fmol of ion concentration in actual amount of 318 pl water solutions from the shift of the resonance frequency. The technique opens the door to microanalysis of biological samples with THz waves and accelerates development of THz lab-on-chip devices.

Secondary Emission Calorimeter Sensor Development

Science.gov (United States)

Winn, David R.; Onel, Yasar

2012-12-01

In a Secondary Emission electron(SEe) detector module, Secondary Emission electrons (SEe) are generated from an SE surface/cathode, when charged hadronic or electromagnetic particles, particularly shower particles, penetrate an SE sampling module placed between absorber materials (Fe, Cu, Pb, W etc) in calorimeters. The SE cathode is a thin (10-50 nm thick) film (simple metal-oxides, or other higher yield materials) on the surface of a metal plate, which serves as the entrance “window” to a compact vacuum vessel (metal or metal-ceramic); this SE film cathode is analogous to a photocathode, and the SEe are similar to p.e., which are then amplified by dynodes, also is in a PMT. SE sensor modules can make use of electrochemically etched/machined or laser-cut metal mesh dynode sheets, as large as ~30 cm square, to amplify the Secondary Emission Electrons (SEe), much like those that compact metal mesh or mesh dynode PMT's use to amplify p.e.'s. The construction requirements easier than a PMT, since the entire final assembly can be done in air; there are no critical controlled thin film depositions, cesiation or other oxygen-excluded processes or other required vacuum activation, and consequently bake-out can be a refractory temperatures; the module is sealed by normal vacuum techniques (welding or brazing or other high temperature joinings), with a simple final heated vacuum pump-out and tip-off. The modules envisioned are compact, high gain, high speed, exceptionally radiation damage resistant, rugged, and cost effective, and can be fabricated in arbitrary tileable shapes. The SE sensor module anodes can be segmented transversely to sizes appropriate to reconstruct electromagnetic cores with high precision. The GEANT4 and existing calorimeter data estimated calorimeter response performance is between 35-50 Secondary Emission electrons per GeV, in a 1 cm thick Cu absorber calorimeter, with a gain per SEe > 105 per SEe, and an e/pi<1.2. The calorimeter pulse width is

Facile and high spatial resolution ratio-metric luminescence thermal mapping in microfluidics by near infrared excited upconversion nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Wang, Yu; Li, Shunbo; Wen, Weijia, E-mail: phwen@ust.hk [Department of Physics, KAUST-HKUST Joint Micro/Nanofluidic Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong Kong); Cao, Wenbin [Nano Science and Technology Program, Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong Kong)

2016-02-01

A local area temperature monitor is important for precise control of chemical and biological processes in microfluidics. In this work, we developed a facile method to realize micron spatial resolution of temperature mapping in a microfluidic channel quickly and cost effectively. Based on the temperature dependent fluorescence emission of NaYF{sub 4}:Yb{sup 3+}, Er{sup 3+} upconversion nanoparticles (UCNPs) under near-infrared irradiation, ratio-metric imaging of UCNPs doped polydimethylsiloxane can map detailed temperature distribution in the channel. Unlike some reported strategies that utilize temperature sensitive organic dye (such as Rhodamine) to achieve thermal sensing, our method is highly chemically inert and physically stable without any performance degradation in long term operation. Moreover, this method can be easily scaled up or down, since the spatial and temperature resolution is determined by an optical imaging system. Our method supplied a simple and efficient solution for temperature mapping on a heterogeneous surface where usage of an infrared thermal camera was limited.

Facile and high spatial resolution ratio-metric luminescence thermal mapping in microfluidics by near infrared excited upconversion nanoparticles

International Nuclear Information System (INIS)

Wang, Yu; Li, Shunbo; Wen, Weijia; Cao, Wenbin

2016-01-01

A local area temperature monitor is important for precise control of chemical and biological processes in microfluidics. In this work, we developed a facile method to realize micron spatial resolution of temperature mapping in a microfluidic channel quickly and cost effectively. Based on the temperature dependent fluorescence emission of NaYF 4 :Yb 3+ , Er 3+ upconversion nanoparticles (UCNPs) under near-infrared irradiation, ratio-metric imaging of UCNPs doped polydimethylsiloxane can map detailed temperature distribution in the channel. Unlike some reported strategies that utilize temperature sensitive organic dye (such as Rhodamine) to achieve thermal sensing, our method is highly chemically inert and physically stable without any performance degradation in long term operation. Moreover, this method can be easily scaled up or down, since the spatial and temperature resolution is determined by an optical imaging system. Our method supplied a simple and efficient solution for temperature mapping on a heterogeneous surface where usage of an infrared thermal camera was limited

Pulse simulations and heat flow measurements for the ATLAS Forward Calorimeter under high-luminosity conditions

CERN Document Server

AUTHOR|(SzGeCERN)758133; Zuber, Kai

The high luminosity phase of the Large Hadron Collider at CERN is an important step for further and more detailed studies of the Standard Model of particle physics as well as searches for new physics. The necessary upgrade of the ATLAS detector is a challenging task as the increased luminosity entails many problems for the different detector parts. The liquid-argon Forward Calorimeter suffers signal-degradation effects and a high voltage drop of the supply potential under high-luminosity conditions. It is possible that the argon starts to boil due to the large energy depositions. The effect of the high-luminosity environment on the liquid-argon Forward Calorimeter has been simulated in order to investigate the level of signal degradation. The results show a curvature of the triangular pulse shape that appears prolonged when increasing the energy deposit. This effect is caused by the drop in the electric potential that produces a decrease in the electric field across the liquid-argon gap in the Forward Calorim...

Upgrading the ATLAS Tile Calorimeter electronics

CERN Document Server

Oreglia, M; The ATLAS collaboration

2013-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the most central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. The main upgrade will occur for the High Luminosity LHC phase (phase 2) which is scheduled around 2022. The upgrade aims at replacing the majority of the on- and off- detector electronics so that all calorimeter signals are directly digitized and sent to the off-detector electronics in the counting room. An ambitious upgrade development program is pursued studying different electronics options. Three different options are presently being investigated for the front-end electronic upgrade. Which one to use will be decided after extensive test beam studies. High speed optical links are used to read out all digitized data to the counting room. For the off-detector electronics a new back-end architecture is being developed, including the initial trigger processing and pipeline memories. A demonstrator prototype read-out for a slice of the ...

Bridging Flows: Microfluidic End‐User Solutions

DEFF Research Database (Denmark)

Sabourin, David

Microfluidic applications hold promise for many different end‐users both within and outside, and across many different research communities. Despite the benefits of microfluidic approaches, adoption and implementation thereof is often hindered by practical issues. Microfluidic components which......‐integrated interconnection and miniaturized peristaltic pump solutions were then combined into modular microfluidic systems. One system provides high interconnection numbers/density and allows many possible configurations. Additionally, and apart from many other accounts of modular microfluidic solutions, methods...... for control and actuation of microfluidic networks built from the modular components is described. Prototypes of the microfluidic system have begun to be distributed to external collaborators and researcher parties. These end‐users will assist in the validation of the approach and ultimately fulfil the key...

Development and simulation of microfluidic Wheatstone bridge for high-precision sensor

International Nuclear Information System (INIS)

Shipulya, N D; Konakov, S A; Krzhizhanovskaya, V V

2016-01-01

In this work we present the results of analytical modeling and 3D computer simulation of microfluidic Wheatstone bridge, which is used for high-accuracy measurements and precision instruments. We propose and simulate a new method of a bridge balancing process by changing the microchannel geometry. This process is based on the “etching in microchannel” technology we developed earlier (doi:10.1088/1742-6596/681/1/012035). Our method ensures a precise control of the flow rate and flow direction in the bridge microchannel. The advantage of our approach is the ability to work without any control valves and other active electronic systems, which are usually used for bridge balancing. The geometrical configuration of microchannels was selected based on the analytical estimations. A detailed 3D numerical model was based on Navier-Stokes equations for a laminar fluid flow at low Reynolds numbers. We investigated the behavior of the Wheatstone bridge under different process conditions; found a relation between the channel resistance and flow rate through the bridge; and calculated the pressure drop across the system under different total flow rates and viscosities. Finally, we describe a high-precision microfluidic pressure sensor that employs the Wheatstone bridge and discuss other applications in complex precision microfluidic systems. (paper)

Reassembling and testing of a high-precision heat capacity drop calorimeter. Heat capacity of some polyphenyls at T = 298.15 K

Energy Technology Data Exchange (ETDEWEB)

Santos, Luis M.N.B.F., E-mail: lbsantos@fc.up.pt [Centro de Investigacao em Quimica, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); Rocha, Marisa A.A.; Rodrigues, Ana S.M.C. [Centro de Investigacao em Quimica, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); Stejfa, Vojtech; Fulem, Michal [Department of Physical Chemistry, Institute of Chemical Technology, Technicka 5, CZ-166 28 Prague 6 (Czech Republic); Bastos, Margarida [Centro de Investigacao em Quimica, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal)

2011-12-15

Graphical abstract: Highlights: > We present the reassembling, improvement and testing of a high-precision C{sub p} drop calorimeter. > The apparatus was tested, using benzoic acid and hexafluorobenzene. > The high sensitivity of the apparatus is comparable to the one obtained in adiabatic calorimetry. > Heat capacities at T = 298.15 K of some polyphenyls were measured. > Subtle heat capacity differences among position isomers (ortho, meta, para) were detected. - Abstract: The description of the reassembling and testing of a twin heat conduction, high-precision, drop microcalorimeter for the measurement of heat capacities of small samples are presented. The apparatus, originally developed and used at the Thermochemistry Laboratory, Lund, Sweden, has now been reassembled and modernized, with changes being made as regarding temperature sensors, electronics and data acquisition system. The apparatus was thereafter thoroughly tested, using benzoic acid and hexafluorobenzene as test substances. The accuracy of the C{sub p,m}{sup 0} (298.15 K) data obtained with this apparatus is comparable to that achieved by high-precision adiabatic calorimetry. Here we also present the results of heat capacity measurements on of some polyphenyls (1,2,3-triphenylbenzene, 1,3,5-triphenylbenzene, p-terphenyl, m-terphenyl, o-terphenyl, p-quaterphenyl) at T = 298.15 K, measured with the renewed high precision heat capacity drop calorimeter system. The high resolution and accuracy of the obtained heat capacity data enabled differentiation among the ortho-, meta-, and para-phenyl isomers.

Track segments in hadronic showers in a highly granular scintillator-steel hadron calorimeter

Czech Academy of Sciences Publication Activity Database

Adloff, C.; Blaising, J.J.; Chefdeville, M.; Cvach, Jaroslav; Gallus, Petr; Havránek, Miroslav; Janata, Milan; Kvasnička, Jiří; Lednický, Denis; Marčišovský, Michal; Polák, Ivo; Popule, Jiří; Tomášek, Lukáš; Růžička, Pavel; Šícho, Petr; Smolík, Jan; Vrba, Václav; Zálešák, Jaroslav

2013-01-01

Roč. 8, Sep (2013), s. 1-22 ISSN 1748-0221 R&D Projects: GA MŠk LC527; GA MŠk LA09042 Institutional support: RVO:68378271 Keywords : calorimeters * detector modelling and simulations * analysis and statistical methods Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.526, year: 2013

Comparison of two highly granular hadronic calorimeter concepts

International Nuclear Information System (INIS)

Neubueser, Coralie

2016-11-01

The CALICE collaboration develops hadron calorimeter technologies with high granularity for future electron-positron linear colliders. These technologies differ in active material, granularity and their readout and thus their energy reconstruction schemes. The Analogue Hadron Calorimeter (AHCAL), based on scintillator tiles with Silicon Photomultiplier readout, measures the signal amplitude of the energy deposition in the cells of at most 3 x 3 cm"2 size. The Digital, Resistive Plate Chamber (RPC) based, HCAL (DHCAL) detects hits above a certain threshold by firing pad sensors of 1 x 1 cm"2. A 2 bit readout is provided by the, also RPC based, Semi-Digital HCAL (SDHCAL), which counts hits above three different thresholds per 1 x 1 cm"2 pad. All three calorimeter concepts have been realised in 1 m"3 prototypes with interleaved steel absorber and tested at various test beams. The differences in active medium, granularity and readout have different impacts on the energy resolution and need to be studied independently. This analysis concentrates on the comparison between these technologies by investigating the impact of the different energy reconstruction schemes on the energy resolution of the AHCAL testbeam data and simulation. Additionally, a so-called software compensation algorithm is developed to weight hits dependent on their energy content and correct for the difference in the response to the electromagnetic and hadronic sub-showers (e/h≠1) and thus reduce the influence of fluctuations in the π"0 generation. The comparison of the energy resolutions revealed that it is mandatory for the AHCAL with 3 x 3 cm"2 cell size to have analogue signal readout, to apply the software compensation algorithm and thus achieve the best possible energy resolution. The effect of the granularity is studied with a simulation of the AHCAL with 1 x 1 cm"2 cell size, and it has been found that to achieve the best possible energy resolution the semi-digital energy reconstruction is

Calorimeter probes for measuring high thermal flux. [in electric-arc jet facilities for planetary entry heating simulation

Science.gov (United States)

Russell, L. D.

1979-01-01

The paper describes expendable, slug-type calorimeter probes developed for measuring high heat-flux levels of 10-30 kW/sq cm in electric-arc jet facilities. The probes are constructed with thin tungsten caps mounted on Teflon bodies; the temperature of the back surface of the tungsten cap is measured, and its rate of change gives the steady-state, absorbed heat flux as the calorimeter probe heats to destruction when inserted into the arc jet. It is concluded that the simple construction of these probes allows them to be expendable and heated to destruction to obtain a measurable temperature slope at high heating rates.

Commercialization of microfluidic devices.

Science.gov (United States)

Volpatti, Lisa R; Yetisen, Ali K

2014-07-01

Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited diffusion into consumer products. This article analyzes the microfluidics market, identifies issues, and highlights successful commercialization strategies. Addressing niche markets and establishing compatibility with existing workflows will accelerate market penetration. Copyright © 2014 Elsevier Ltd. All rights reserved.

Effects of high-energy particle showers on the embedded front-end electronics of an electromagnetic calorimeter for a future lepton collider

CERN Document Server

Adloff, C.; Repond, J.; Smith, J.; Trojand, D.; Xia, L.; Baldolemar, E.; Li, J.; Park, S.T.; Sosebee, M.; White, A.P.; Yu, J.; Mikami, Y.; Watson, N.K.; Mavromanolakis, G.; Thomson, M.A.; Ward, D.R.; Yan, W.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Benyamna, M.; Carloganu, C.; Fehr, F.; Gay, P.; Manen, S.; Royer, L.; Blazey, G.C.; Dyshkant, A.; Zutshi, V.; Hostachy, J.Y.; Morin, L.; Cornett, U.; David, D.; Fabbri, R.; Falley, G.; Gadow, K.; Garutti, E.; Gottlicher, P.; Gunter, C.; Karstensen, S.; Krivan, F.; Lucaci-Timoce, A.I.; Lu, S.; Lutz, B.; Marchesini, I.; Meyer, N.; Morozov, S.; Morgunov, V.; Reinecke, M.; Sefkow, F.; Smirnov, P.; Terwort, M.; Vargas-Trevino, A.; Wattimena, N.; Wendt, O.; Feege, N.; Haller, J.; Richter, S.; Samson, J.; Eckert, P.; Kaplan, A.; Schultz-Coulon, H.Ch.; Shen, W.; Stamen, R.; Tadday, A.; Bilki, B.; Norbeck, E.; Onel, Y.; Kawagoe, K.; Uozumi, S.; Dauncey, P.D.; Magnan, A.M.; Bartsch, V.; Salvatore, F.; Laktineh, I.; Calvo Alamillo, E.; Fouz, M.C.; Puerta-Pelayo, J.; Frey, A.; Kiesling, C.; Simon, F.; Bonis, J.; Bouquet, B.; Callier, S.; Cornebise, P.; Doublet, Ph.; Dulucq, F.; Faucci Giannelli, M.; Fleury, J.; Li, H.; Martin-Chassard, G.; Richard, F.; de la Taille, Ch.; Poschl, R.; Raux, L.; Seguin-Moreau, N.; Wicek, F.; Anduze, M.; Boudry, V.; Brient, J.C.; Jeans, D.; Mora de Freitas, P.; Musat, G.; Reinhard, M.; Ruan, M.; Videau, H.; Marcisovsky, M.; Sicho, P.; Vrba, V.; Zalesak, J.; Belhorma, B.; Ghazlane, H.

2011-01-01

Application Specific Integrated Circuits, ASICs, similar to those envisaged for the readout electronics of the central calorimeters of detectors for a future lepton collider have been exposed to high-energy electromagnetic showers. A salient feature of these calorimeters is that the readout electronics will be embedded into the calorimeter layers. In this article it is shown that interactions of shower particles in the volume of the readout electronics do not alter the noise pattern of the ASICs. No signal at or above the MIP level has been observed during the exposure. The upper limit at the 95% confidence level on the frequency of faked signals is smaller than 1x10^{-5} for a noise threshold of about 60% of a MIP. For ASICs with similar design to those which were tested, it can thus be largely excluded that the embedding of the electronics into the calorimeter layers compromises the performance of the calorimeters.

FoCal – A high granularity electromagnetic calorimeter for forward direct photon measurements

NARCIS (Netherlands)

Zhang, C.

2017-01-01

The measurement of direct photon production at forward rapidity (y∼3−5) at the LHC provides access to the structure of protons and nuclei at very small values of fractional momentum (x∼10−5). FoCal, an extremely-high-granularity Forward Calorimeter covering 3.3<η<5.3 is proposed as a detector

Controlled growth of silica-titania hybrid functional nanoparticles through a multistep microfluidic approach.

Science.gov (United States)

Shiba, K; Sugiyama, T; Takei, T; Yoshikawa, G

2015-11-11

Silica/titania-based functional nanoparticles were prepared through controlled nucleation of titania and subsequent encapsulation by silica through a multistep microfluidic approach, which was successfully applied to obtaining aminopropyl-functionalized silica/titania nanoparticles for a highly sensitive humidity sensor.

HistoFlex-a microfluidic device providing uniform flow conditions enabling highly sensitive, reproducible and quantitative in situ hybridizations

DEFF Research Database (Denmark)

Søe, Martin Jensen; Okkels, Fridolin; Sabourin, David

2011-01-01

A microfluidic device (the HistoFlex) designed to perform and monitor molecular biological assays under dynamic flow conditions on microscope slide-substrates, with special emphasis on analyzing histological tissue sections, is presented. Microscope slides were reversibly sealed onto a cast polyd...

QCALT: A tile calorimeter for KLOE-2 upgrade

Energy Technology Data Exchange (ETDEWEB)

Balla, A.; Ciambrone, P.; Corradi, G. [INFN, Laboratori Nazionali di Frascati, Frascati (Rm) (Italy); Martini, M., E-mail: matteo.martini@lnf.infn.it [INFN, Laboratori Nazionali di Frascati, Frascati (Rm) (Italy); Università degli studi Guglielmo Marconi, Rome (Italy); Paglia, C.; Pileggi, G.; Ponzio, B.; Saputi, A. [INFN, Laboratori Nazionali di Frascati, Frascati (Rm) (Italy); Tagnani, D. [INFN, Sezione di Roma 3, Rome (Italy)

2013-08-01

The upgrade of the DaΦne machine layout requires a modification of the size and position of the inner focusing quadrupoles of KLOE-2, thus asking for the realization of two new calorimeters, named QCALT, covering this area. To improve the reconstruction of K{sub L}→2π{sup 0} events with photons hitting the quadrupoles, a calorimeter with high efficiency to low energy photons (20–300 MeV), time resolution of less than 1 ns and space resolution of few cm, is needed. To match these requirements we are now constructing a scintillator tile calorimeter where each single tile is readout by mean of SiPM for a total granularity of 1760 channels. We show the design of the different calorimeter components and the present status of the construction.

Absolute quantification of DNA methylation using microfluidic chip-based digital PCR.

Science.gov (United States)

Wu, Zhenhua; Bai, Yanan; Cheng, Zule; Liu, Fangming; Wang, Ping; Yang, Dawei; Li, Gang; Jin, Qinghui; Mao, Hongju; Zhao, Jianlong

2017-10-15

Hypermethylation of CpG islands in the promoter region of many tumor suppressor genes downregulates their expression and in a result promotes tumorigenesis. Therefore, detection of DNA methylation status is a convenient diagnostic tool for cancer detection. Here, we reported a novel method for the integrative detection of methylation by the microfluidic chip-based digital PCR. This method relies on methylation-sensitive restriction enzyme HpaII, which cleaves the unmethylated DNA strands while keeping the methylated ones intact. After HpaII treatment, the DNA methylation level is determined quantitatively by the microfluidic chip-based digital PCR with the lower limit of detection equal to 0.52%. To validate the applicability of this method, promoter methylation of two tumor suppressor genes (PCDHGB6 and HOXA9) was tested in 10 samples of early stage lung adenocarcinoma and their adjacent non-tumorous tissues. The consistency was observed in the analysis of these samples using our method and a conventional bisulfite pyrosequencing. Combining high sensitivity and low cost, the microfluidic chip-based digital PCR method might provide a promising alternative for the detection of DNA methylation and early diagnosis of epigenetics-related diseases. Copyright © 2017 Elsevier B.V. All rights reserved.

Search for and selection of novel heavy scintillator crystals for calorimeter design for future high-energy colliders

International Nuclear Information System (INIS)

Ferrere, D.

1993-01-01

The discovery of some particles (Higgs, top,..) foreseen by theoretical models should be achieved at future colliders allowing to reach an energy scale of about 1 TeV. Efficient detectors must be designed to handle the very high luminosity of the LHC collider at CERN. In the intermediate mass region, M Z -2M Z , the diphoton decay mode of a Higgs boson produced inclusively or in association with W boson or a toponium gives good chance of observation. A very high resolution calorimeter with photon angle reconstruction and pion identification capability should detect a Higgs signal with high probability. So a homogeneous crystal calorimeter seems to be suitable. Because of the high luminosity and the high radiation level, a search for a new heavy scintillator has been undertaken. It must have a good radiation hardness (>0.5 MRad in a year) and a fast luminescence decay time (<30 ns). Among 50 crystals or glasses of specific chemical composition tested in transmission, luminescence, decay time, γ/neutrons radiation and light yield, cerium fluoride seems best suited for LHC. The necessity to have a good photon resolution in the intermediate Higgs mass region led us to optimise by Monte Carlo simulations the geometry of the calorimeter, the uniformisation of the light collection and crystal intercalibration parameters. (orig.)

Microfluidics without channels: highly-flexible synthesis on a digital-microfluidic chip for production of diverse PET tracers

Energy Technology Data Exchange (ETDEWEB)

Van Dam, Robert Michael [Univ. of California, Los Angeles, CA (United States)

2010-09-01

Positron emission tomography (PET) imaging is used for fundamental studies of living biological organisms and microbial ecosystems in applications ranging from biofuel production to environmental remediation to the study, diagnosis, and treatment monitoring of human disease. Routine access to PET imaging, to monitor biochemical reactions in living organisms in real time, could accelerate a broad range of research programs of interest to DOE. Using PET requires access to short-lived radioactive-labeled compounds that specifically probe the desired living processes. The overall aims of this project were to develop a miniature liquid-handling technology platform (called “microfluidics”) that increases the availability of diverse PET probes by reducing the cost and complexity of their production. Based on preliminary experiments showing that microfluidic chips can synthesis such compounds, we aimed to advance this technology to improve its robustness, increase its flexibility for a broad range of probes, and increase its user-friendliness. Through the research activities of this project, numerous advances were made; Tools were developed to enable the visualization of radioactive materials within microfluidic chips; Fundamental advances were made in the microfluidic chip architecture and fabrication process to increase its robustness and reliability; The microfluidic chip technology was shown to produce useful quantities of an example PET probes, and methods to further increase the output were successfully pursued; A “universal” chip was developed that could produce multiple types of PET probes, enabling the possibility of “on demand” synthesis of different probes; and Operation of the chip was automated to ensure minimal radiation exposure to the operator Based on the demonstrations of promising technical feasibility and performance, the microfluidic chip technology is currently being commercialized. It is anticipated that costs of microfluidic chips can be

Microfluidics for chemical processing

NARCIS (Netherlands)

Gardeniers, Johannes G.E.

2006-01-01

Microfluidic systems, and more specifically, microfluidic chips, have a number of features that make them particularly useful for the study of chemical reactions on-line. The present paper will discuss two examples, the study of fluidic behaviour at high pressures and the excitation and detection of

Microfluidic Apps for off-the-shelf instruments.

Science.gov (United States)

Mark, Daniel; von Stetten, Felix; Zengerle, Roland

2012-07-21

Within the last decade a huge increase in research activity in microfluidics could be observed. However, despite several commercial success stories, microfluidic chips are still not sold in high numbers in mass markets so far. Here we promote a new concept that could be an alternative approach to commercialization: designing microfluidic chips for existing off-the-shelf instruments. Such "Microfluidic Apps" could significantly lower market entry barriers and provide many advantages: developers of microfluidic chips make use of existing equipment or platforms and do not have to develop instruments from scratch; end-users can profit from microfluidics without the need to invest in new equipment; instrument manufacturers benefit from an expanded customer base due to the new applications that can be implemented in their instruments. Microfluidic Apps could be considered as low-cost disposables which can easily be distributed globally via web-shops. Therefore they could be a door-opener for high-volume mass markets.

On the ionization scintillation calorimeter based on KMgF3 crystal

International Nuclear Information System (INIS)

Buzulutskov, A.F.

1990-01-01

The development of the ionization scintillation calorimeter, using KMgF 3 crystals and high efficiency photocathodes, is proposed. Some characteristics of such calorimeter are compared with those of the high pressure gas one. 6 refs.; 2 figs.; 2 tabs

Upgrading ATLAS Fast Calorimeter Simulation

CERN Document Server

Heath, Matthew Peter; The ATLAS collaboration

2017-01-01

Producing the very large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing CPU requirements when detailed detector simulations are not needed. During the LHC Run-1, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and it can be tuned to data more easily than Geant4. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim aims to overcome some limitations of the first version by improving the description of s...

ATLAS calorimeters: Run-2 performances and Phase-II upgrades

CERN Document Server

Boumediene, Djamel Eddine; The ATLAS collaboration

2017-01-01

The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to $10^{34} cm^{-2} s^{-1}$. A Liquid Argon-lead sampling (LAr) calorimeter is employed as electromagnetic and hadronic calorimeters, except in the barrel region, where a scintillator-steel sampling calorimeter (TileCal) is used as hadronic calorimeter. This presentation gives first an overview of the detector operation and data quality, as well as of the achieved performances of the ATLAS calorimetry system. Additionally the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC) are presented. For the HL-LHC, the instantaneous luminosity is expected to increase up to $L \\simeq 7.5 × 10^{34} cm^{-2} s^{-1}$ and the average pile-up up to 200 interactions per bunch crossing. The major R&D item is the upgrade of the electronics for both LAr and Tile calorimeters in order to cope with longer latenc...

Performance of the ATLAS hadronic Tile calorimeter

CERN Document Server

Mlynarikova, Michaela; The ATLAS collaboration

2017-01-01

The ATLAS Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for reconstruction of hadrons, jets, tau-particles and missing transverse energy. TileCal is a scintillator-steel sampling calorimeter and it covers the region of pseudorapidity < 1.7. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal frontend electronics reads out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV. Each stage of the signal production from scintillation light to the signal reconstruction is monitored and calibrated. The performance of the calorimeter has been studied in-situ employing cosmic ray muons and a large sample of proton-proton collisions acquired during the operations of the LHC. Prompt isolated muons of high momentum fro...

Performance of the ATLAS hadronic Tile calorimeter

CERN Document Server

Mlynarikova, Michaela; The ATLAS collaboration

2017-01-01

The Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for reconstruction of hadrons, jets, tau-particles and missing transverse energy. TileCal is a scintillator-steel sampling calorimeter and it covers the region of pseudorapidity < 1.7. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal frontend electronics reads out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV. Each stage of the signal production from scintillation light to the signal reconstruction is monitored and calibrated. The performance of the calorimeter has been studied in-situ employing cosmic ray muons and a large sample of proton-proton collisions acquired during the operations of the LHC. Prompt isolated muons of high momentum from elec...

Study of a novel electromagnetic liquid argon calorimeter — the TGT

Science.gov (United States)

Berger, C.; Braunschweig, W.; Geulig, E.; Schöntag, M.; Siedling, R.; Wlochal, M.; Putzer, A.; Wotschack, J.; Cheplakov, A.; Feshchenko, A.; Kazarinov, M.; Kukhtin, V.; Ladygin, E.; Obudovskij, V.; Geweniger, C.; Hanke, P.; Kluge, E.-E.; Krause, J.; Schmidt, M.; Stenzel, H.; Tittel, K.; Wunsch, M.; Zerwas, D.; Bruncko, D.; Jusko, A.; Kocper, B.; Lupták, M.; Aderholz, M.; Bán, J.; Brettel, H.; Dydak, F.; Fent, J.; Frey, H.; Huber, J.; Jakobs, K.; Kiesling, C.; Kiryunin, A. E.; Oberlack, H.; Ribarics, P.; Schacht, P.; Stiegler, U.; Bogolyubsky, M. Y.; Buyanov, O. V.; Chekulaev, S. V.; Kurchaninov, L. L.; Levitsky, M. S.; Maximov, V. V.; Minaenko, A. A.; Moiseev, A. M.; Semenov, P. A.; Tikhonov, V. V.; Straumann, U.

1995-02-01

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a testbeam exposure.

The CPLEAR Electromagnetic Calorimeter

CERN Document Server

Adler, R; Bal, F; Behnke, O; Bloch, P; Damianoglou, D; Dechelette, Paul; Dröge, M; Eckart, B; Felder, C; Fetscher, W; Fidecaro, Maria; Garreta, D; Gerber, H J; Gumplinger, P; Guyon, D; Johner, H U; Löfstedt, B; Kern, J; Kokkas, P; Krause, H; Mall, U; Marin, C P; Nanni, F; Pagels, B; Pavlopoulos, P; Petit, P; Polivka, G; Rheme, C; Ruf, T; Santoni, C; Schaller, L A; Schopper, A; Tauscher, Ludwig; Tschopp, H; Weber, P; Wendler, H; Witzig, C; Wolter, M

1997-01-01

A large-acceptance lead/gas sampling electromagnetic calorimeter (ECAL) was constructed for the CPLEAR experiment to detect photons from decays of $\\pi^0$s with momentum $p_{\\pi^0} \\le 800$ MeV$/c$. The main purpose of the ECAL is to determine the decay vertex of neutral-kaon decays $\\ko \\rightarrow \\pi^0\\pi^0 \\rightarrow 4 \\gamma$ and $\\ko \\rightarrow \\pi^0\\pi^0\\pi^0 \\rightarrow 6 \\gamma$. This requires a position-sensitive photon detector with high spatial granularity in $r$-, $\\varphi$-, and $z$-coordinates. The ECAL --- a barrel without end-caps located inside a magnetic field of 0.44 T --- consists of 18 identical concentric layers. Each layer of $1/3$ radiation length (X${_0}$) contains a converter plate followed by small cross-section high-gain tubes of 2640 mm active length which are sandwiched by passive pick-up strip plates. The ECAL, with a total of $6$ X${_0}$, has an energy resolution of $\\sigma (E)/E \\approx 13\\% / \\sqrt{E(\\mathrm{GeV})}$ and a position resolution of 4.5 mm for the shower foot. ...

Microfluidic Transducer for Detecting Nanomechanical Movements of Bacteria

Science.gov (United States)

Kara, Vural; Ekinci, Kamil

2017-11-01

Various nanomechanical movements of bacteria are currently being explored as an indication of bacterial viability. Most notably, these movements have been observed to subside rapidly and dramatically when the bacteria are exposed to an effective antibiotic. This suggests that monitoring bacterial movements, if performed with high fidelity, can offer a path to various clinical microbiological applications, including antibiotic susceptibility tests. Here, we introduce a robust and sensitive microfluidic transduction technique for detecting the nanomechanical movements of bacteria. The technique is based on measuring the electrical fluctuations in a microchannel which the bacteria populate. These electrical fluctuations are caused by the swimming of motile, planktonic bacteria and random oscillations of surface-immobilized bacteria. The technique provides enough sensitivity to detect even the slightest movements of a single cell and lends itself to smooth integration with other microfluidic methods and devices; it may eventually be used for rapid antibiotic susceptibility testing. We acknowledge support from Boston University Office of Technology Development, Boston University College of Engineering, NIH (1R03AI126168-01) and The Wallace H. Coulter Foundation.

Performance of a high-precision calorimeter for the measurement of the antineutrino-source strength in the SOX experiment

Energy Technology Data Exchange (ETDEWEB)

Altenmueller, Konrad [Technische Universitaet Muenchen (Germany); Collaboration: BOREXINO-Collaboration

2016-07-01

A calorimeter was developed to measure the thermal power and thus the antineutrino-generation rate of a {sup 144}Ce - {sup 144}Pr antineutrino-source with < 1% overall accuracy for the SOX experiment. SOX is searching for neutrino oscillations at short baselines with the Borexino detector to investigate the existence of eV-scale sterile neutrinos. The calorimeter design is based on a copper heat exchanger with integrated water lines for the heat extraction, mounted around the source. A high precision measurement is possible thanks to an elaborate thermal insulation. In this talk, the design of the calorimeter is reviewed and results of calibration measurements are presented. The thermal insulation of the system was examined and heat losses were quantified. The methods to reconstruct the source power and the decay rate from measurements are described.

Integration of an optical CMOS sensor with a microfluidic channel allows a sensitive readout for biological assays in point-of-care tests.

Science.gov (United States)

Van Dorst, Bieke; Brivio, Monica; Van Der Sar, Elfried; Blom, Marko; Reuvekamp, Simon; Tanzi, Simone; Groenhuis, Roelf; Adojutelegan, Adewole; Lous, Erik-Jan; Frederix, Filip; Stuyver, Lieven J

2016-04-15

In this manuscript, a microfluidic detection module, which allows a sensitive readout of biological assays in point-of-care (POC) tests, is presented. The proposed detection module consists of a microfluidic flow cell with an integrated Complementary Metal-Oxide-Semiconductor (CMOS)-based single photon counting optical sensor. Due to the integrated sensor-based readout, the detection module could be implemented as the core technology in stand-alone POC tests, for use in mobile or rural settings. The performance of the detection module was demonstrated in three assays: a peptide, a protein and an antibody detection assay. The antibody detection assay with readout in the detection module proved to be 7-fold more sensitive that the traditional colorimetric plate-based ELISA. The protein and peptide assay showed a lower limit of detection (LLOD) of 200 fM and 460 fM respectively. Results demonstrate that the sensitivity of the immunoassays is comparable with lab-based immunoassays and at least equal or better than current mainstream POC devices. This sensitive readout holds the potential to develop POC tests, which are able to detect low concentrations of biomarkers. This will broaden the diagnostic capabilities at the clinician's office and at patient's home, where currently only the less sensitive lateral flow and dipstick POC tests are implemented. Copyright © 2015 Elsevier B.V. All rights reserved.

Methods of making microfluidic devices

KAUST Repository

Buttner, Ulrich

2017-06-01

Microfluidics has advanced in terms of designs and structures, however, fabrication methods are either time consuming or expensive to produce, in terms of the facilities and equipment needed. A fast and economically viable method is provided to allow, for example, research groups to have access to microfluidic fabrication. Unlike most fabrication methods, a method is provided to fabricate a microfluidic device in one step. In an embodiment, a resolution of 50 micrometers was achieved by using maskless high-resolution digital light projection (MDLP). Bonding and channel fabrication of complex or simple structures can be rapidly incorporated to fabricate the microfluidic devices.

Performance evaluation of a commercially available heat flow calorimeter and applicability assessment for safeguarding special nuclear materials

International Nuclear Information System (INIS)

Bracken, D.S.; Biddle, R.; Rudy, C.

1998-01-01

The performance characteristics of a commercially available heat-flow calorimeter will be presented. The heat-flow sensors within the calorimeter are based on thermopile technology with a vendor-quoted sensitivity of 150 microV/mW. The calorimeter is a full-twin design to compensate for ambient temperature fluctuations. The efficacy of temperature fluctuation compensations will also be detailed. Finally, an assessment of design applicability to special nuclear materials control and accountability and safeguarding will be presented

Construction techniques of the high resolution lead / scintillating fibre electromagnetic calorimeter for the KLOE experiment

International Nuclear Information System (INIS)

Anelli, M.; Bisogni, G.; Ceccarelli, A.

1997-07-01

The electromagnetic calorimeter of the KLOE experiment is a lead-scintillating fibre sampling device. This calorimeter is arranged as a 'barrel', closed at both ends with an 'end-cap'. The barrel consists in 24 modules defining a cylinder, 4.3 long, with 4 m inner diameter. Each end-cap consists of 32 modules running vertically along the chords of the circle inscribed into the barrel. In this paper the calorimeter construction techniques are described

Construction techniques of the high resolution lead / scintillating fibre electromagnetic calorimeter for the KLOE experiment

Energy Technology Data Exchange (ETDEWEB)

Anelli, M; Bisogni, G; Ceccarelli, A [INFN, Laboratori Nazionali di Frascati, Rome (Italy); and others

1997-07-01

The electromagnetic calorimeter of the KLOE experiment is a lead-scintillating fibre sampling device. This calorimeter is arranged as a `barrel`, closed at both ends with an `end-cap`. The barrel consists in 24 modules defining a cylinder, 4.3 long, with 4 m inner diameter. Each end-cap consists of 32 modules running vertically along the chords of the circle inscribed into the barrel. In this paper the calorimeter construction techniques are described.

High performance wash-free magnetic bioassays through microfluidically enhanced particle specificity.

Science.gov (United States)

Bechstein, Daniel J B; Lee, Jung-Rok; Ooi, Chin Chun; Gani, Adi W; Kim, Kyunglok; Wilson, Robert J; Wang, Shan X

2015-06-30

Magnetic biosensors have emerged as a sensitive and versatile platform for high performance medical diagnostics. These magnetic biosensors require well-tailored magnetic particles as detection probes, which need to give rise to a large and specific biological signal while showing very low nonspecific binding. This is especially important in wash-free bioassay protocols, which do not require removal of particles before measurement, often a necessity in point of care diagnostics. Here we show that magnetic interactions between magnetic particles and magnetized sensors dramatically impact particle transport and magnetic adhesion to the sensor surfaces. We investigate the dynamics of magnetic particles' biomolecular binding and magnetic adhesion to the sensor surface using microfluidic experiments. We elucidate how flow forces can inhibit magnetic adhesion, greatly diminishing or even eliminating nonspecific signals in wash-free magnetic bioassays, and enhancing signal to noise ratios by several orders of magnitude. Our method is useful for selecting and optimizing magnetic particles for a wide range of magnetic sensor platforms.

Two different cases of calorimetry in high energy physics: the ATLAS liquid argon electromagnetic end cap and the ZEUS forward plug calorimeter

International Nuclear Information System (INIS)

Garcia Lopez, G.

2000-03-01

The thesis is organised as follows: chapter 1 introduces the basic concepts of calorimetry in high energy physics; chapters 2-5 are devoted to the ATLAS EMEC calorimeter; chapters 6-7 deal with the ZEUS FPC; finally chapter 8 compares the performance of the two calorimeters

Testing Hadronic Interaction Models using a Highly Granular Silicon-Tungsten Calorimeter

CERN Document Server

Bilki, B.; Schlereth, J.; Xia, L.; Deng, Z.; Li, Y.; Wang, Y.; Yue, Q.; Yang, Z.; Eigen, G.; Mikami, Y.; Price, T.; Watson, N.K.; Thomson, M.A.; Ward, D.R.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Carloganu, C.; Chang, S.; Khan, A.; Kim, D.H.; Kong, D.J.; Oh, Y.D.; Blazey, G.C.; Dyshkant, A.; Francis, K.; Lima, J.G.R.; Salcido, P.; Zutshi, V.; Boisvert, V.; Green, B.; Misiejuk, A.; Salvatore, F.; Kawagoe, K.; Miyazaki, Y.; Sudo, Y.; Suehara, T.; Tomita, T.; Ueno, H.; Yoshioka, T.; Apostolakis, J.; Folger, G.; Ivantchenko, V.; Ribon, A.; Uzhinskiy, V.; Cauwenbergh, S.; Tytgat, M.; Zaganidis, N.; Hostachy, J.Y.; Morin, L.; Gadow, K.; Göttlicher, P.; Günter, C.; Krüger, K.; Lutz, B.; Reinecke, M.; Sefkow, F.; Feege, N.; Garutti, E.; Laurien, S.; Lu, S.; Marchesini, I.; Matysek, M.; Ramilli, M.; Kaplan, A.; Norbeck, E.; Northacker, D.; Onel, Y.; Kim, E.J.; van Doren, B.; Wilson, G.W.; Wing, M.; Bobchenko, B.; Chadeeva, M.; Chistov, R.; Danilov, M.; Drutskoy, A.; Epifantsev, A.; Markin, O.; Mizuk, R.; Novikov, E.; Popov, V.; Rusinov, V.; Tarkovsky, E.; Besson, D.; Popova, E.; Gabriel, M.; Kiesling, C.; Simon, F.; Soldner, C.; Szalay, M.; Tesar, M.; Weuste, L.; Amjad, M.S.; Bonis, J.; Callier, S.; Conforti di Lorenzo, S.; Cornebise, P.; Doublet, Ph.; Dulucq, F.; Faucci-Giannelli, M.; Fleury, J.; Frisson, T.; Kégl, B.; van der Kolk, N.; Li, H.; Martin-Chassard, G.; Richard, F.; de la Taille, Ch.; Pöschl, R.; Raux, L.; Rouëne, J.; Seguin-Moreau, N.; Anduze, M.; Balagura, V.; Becheva, E.; Boudry, V.; Brient, J.-C.; Cornat, R.; Frotin, M.; Gastaldi, F.; Magniette, F.; Matthieu, A.; Mora de Freitas, P.; Videau, H.; Augustin, J.-E.; David, J.; Ghislain, P.; Lacour, D.; Lavergne, L.; Zacek, J.; Cvach, J.; Gallus, P.; Havranek, M.; Janata, M.; Kvasnicka, J.; Lednicky, D.; Marcisovsky, M.; Polak, I.; Popule, J.; Tomasek, L.; Tomasek, M.; Ruzicka, P.; Sicho, P.; Smolik, J.; Vrba, V.; Zalesak, J.; Jeans, D.; Götze, M.

2015-09-11

A detailed study of hadronic interactions is presented using data recorded with the highly granular CALICE silicon-tungsten electromagnetic calorimeter. Approximately 600,000 selected negatively changed pion events at energies between 2 and 10 GeV have been studied. The predictions of several physics models available within the GEANT4 simulation tool kit are compared to this data. Although a reasonable overall description of the data is observed, there are significant quantitative discrepancies in the longitudinal and transverse distributions of reconstructed energy.

Interactions of Particles with Momenta of 1–10 GeV in a Highly Granular Hadronic Calorimeter with Tungsten Absorbers

CERN Document Server

Lam, Ching Bon; van Eijk, Bob

Linear electron-positron colliders are proposed to complement and extend the physics programme of the Large Hadron Collider at CERN. In order to satisfy the physics goal requirements at linear colliders, detector concepts based on the Particle Flow approach are developed. Central to this approach are a high resolution tracker and a highly granular calorimeter which provide excellent jet energy resolution and background separation. The Compact Linear Collider (CLIC) is an electron-positron collider under study, aiming at centre-of-mass energies up to 3TeV. For the barrel hadronic calorimeter of experiments at CLIC, a detector with tungsten absorber plates is considered, as it is able to contain shower jets while keeping the diameter of the surrounding solenoid magnet limited. A highly granular analogue hadron calorimeter with tungsten absorbers was built by the CALICE collaboration. This thesis presents the analysis of the low-momentum data (1 GeV $\\leq$ p $\\leq$ 10 GeV) recorded in 2010 at the CERN Proton Syn...

Microfluidic electronics.

Science.gov (United States)

Cheng, Shi; Wu, Zhigang

2012-08-21

Microfluidics, a field that has been well-established for several decades, has seen extensive applications in the areas of biology, chemistry, and medicine. However, it might be very hard to imagine how such soft microfluidic devices would be used in other areas, such as electronics, in which stiff, solid metals, insulators, and semiconductors have previously dominated. Very recently, things have radically changed. Taking advantage of native properties of microfluidics, advances in microfluidics-based electronics have shown great potential in numerous new appealing applications, e.g. bio-inspired devices, body-worn healthcare and medical sensing systems, and ergonomic units, in which conventional rigid, bulky electronics are facing insurmountable obstacles to fulfil the demand on comfortable user experience. Not only would the birth of microfluidic electronics contribute to both the microfluidics and electronics fields, but it may also shape the future of our daily life. Nevertheless, microfluidic electronics are still at a very early stage, and significant efforts in research and development are needed to advance this emerging field. The intention of this article is to review recent research outcomes in the field of microfluidic electronics, and address current technical challenges and issues. The outlook of future development in microfluidic electronic devices and systems, as well as new fabrication techniques, is also discussed. Moreover, the authors would like to inspire both the microfluidics and electronics communities to further exploit this newly-established field.

Barrel calorimeter of the CMD-3 detector

Energy Technology Data Exchange (ETDEWEB)

Shebalin, V. E., E-mail: V.E.Shebalin@inp.nsk.su; Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S. [Russian Academy of Sciences, Budker Institute of Nuclear Physics, Siberian Branch (Russian Federation); Epifanov, D. A. [University of Tokyo, Department of Physics (Japan); Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V. [Russian Academy of Sciences, Budker Institute of Nuclear Physics, Siberian Branch (Russian Federation)

2015-12-15

The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ∼6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV.

Barrel calorimeter of the CMD-3 detector

International Nuclear Information System (INIS)

Shebalin, V. E.; Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S.; Epifanov, D. A.; Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V.

2015-01-01

The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ∼6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV

An easy-to-use microfluidic interconnection system to create quick and reversibly interfaced simple microfluidic devices

DEFF Research Database (Denmark)

Pfreundt, Andrea; Andersen, Karsten Brandt; Dimaki, Maria

2015-01-01

The presented microfluidic interconnection system provides an alternative for the individual interfacing of simple microfluidic devices fabricated in polymers such as polymethylmethacrylate, polycarbonate and cyclic olefin polymer. A modification of the device inlet enables the direct attachment...... pressures above 250 psi and therefore supports applications with high flow rates or highly viscous fluids. The ease of incorporation, configuration, fabrication and use make this interconnection system ideal for the rapid prototyping of simple microfluidic devices or other integrated systems that require...... microfluidic interfaces. It provides a valuable addition to the toolbox of individual and small arrays of connectors suitable for micromachined or template-based injection molded devices since it does not require protruding, threaded or glued modifications on the inlet and avoids bulky and expensive fittings....

Validation of GEANT4 Monte Carlo models with a highly granular scintillator-steel hadron calorimeter

Czech Academy of Sciences Publication Activity Database

Adloff, C.; Blaha, J.; Blaising, J.J.; Cvach, Jaroslav; Gallus, Petr; Havránek, Miroslav; Janata, Milan; Kvasnička, Jiří; Lednický, Denis; Marčišovský, Michal; Polák, Ivo; Popule, Jiří; Tomášek, Lukáš; Tomášek, Michal; Růžička, Pavel; Šícho, Petr; Smolík, Jan; Vrba, Václav; Zálešák, Jaroslav

2013-01-01

Roč. 8, Jul (2013), s. 1-33 ISSN 1748-0221 Institutional support: RVO:68378271 Keywords : interaction of radiation with matter * calorimeter methods * detector modelling and simulations Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.526, year: 2013

Family reunion for the UA2 calorimeter

CERN Multimedia

Abha Eli Phoboo

2015-01-01

After many years in CERN’s Microcosm exhibition, the last surviving UA2 central calorimeter module has been moved to Hall 175, the technical development laboratory of the ATLAS Tile Hadronic Calorimeter (Tilecal). The UA2 and ATLAS calorimeters are cousins, as both were designed by Otto Gildemeister. Now side by side, the calorimeters illustrate the progress made in sampling organic scintillator calorimeters over the past 35 years.   The ATLAS Tile Calorimeter prototypes (left) and the UA2 central calorimeter (right) in Hall 175. (Image: Mario Campanelli/ATLAS.) From 1981 to 1990, the UA2 experiment was one of the two detectors on CERN’s flagship accelerator, the SPS. At the heart of the UA2 detector was the central calorimeter. It was made up of 24 slices – each weighing four tonnes – arranged like orange segments around the collision point. These calorimeter slices played a central role in the research carried out by UA2 for the discovery of W bosons...

Microfluidics on liquid handling stations (μF-on-LHS): a new industry-compatible microfluidic platform

Science.gov (United States)

Kittelmann, Jörg; Radtke, Carsten P.; Waldbaur, Ansgar; Neumann, Christiane; Hubbuch, Jürgen; Rapp, Bastian E.

2014-03-01

Since the early days microfluidics as a scientific discipline has been an interdisciplinary research field with a wide scope of potential applications. Besides tailored assays for point-of-care (PoC) diagnostics, microfluidics has been an important tool for large-scale screening of reagents and building blocks in organic chemistry, pharmaceutics and medical engineering. Furthermore, numerous potential marketable products have been described over the years. However, especially in industrial applications, microfluidics is often considered only an alternative technology for fluid handling, a field which is industrially mostly dominated by large-scale numerically controlled fluid and liquid handling stations. Numerous noteworthy products have dominated this field in the last decade and have been inhibited the widespread application of microfluidics technology. However, automated liquid handling stations and microfluidics do not have to be considered as mutually exclusive approached. We have recently introduced a hybrid fluidic platform combining an industrially established liquid handling station and a generic microfluidic interfacing module that allows probing a microfluidic system (such as an essay or a synthesis array) using the instrumentation provided by the liquid handling station. We term this technology "Microfluidic on Liquid Handling Stations (μF-on-LHS)" - a classical "best of both worlds"- approach that allows combining the highly evolved, automated and industry-proven LHS systems with any type of microfluidic assay. In this paper we show, to the best of our knowledge, the first droplet microfluidics application on an industrial LHS using the μF-on-LHS concept.

Performance of the CMS precision electromagnetic calorimeter at the LHC Run II and prospects for high-luminosity LHC

CERN Document Server

Negro, Giulia

2017-01-01

The Compact Muon Solenoid (CMS) electromagnetic calorimeter (ECAL) is a high-performance calorimeter wich will operate also at the High Luminosity Large Hadron Collider (HL-LHC). This talk will describe the strategies that have been employed to maintain the excellent performance of the CMS ECAL throughout Run 2. Performance results from the 2015-2016 data taking periods will be shown and an outlook on the expected Run 2 performance in the years to come will be provided. The status and plans for the upgraded ECAL barrel electronics for the HL-LHC will be presented, based on recent results from simulations, laboratory tests, and test beam measurements of prototype devices.

Research and Development for a Free-Running Readout System for the ATLAS LAr Calorimeters at the High Luminosity LHC

CERN Document Server

AUTHOR|(SzGeCERN)758889; The ATLAS collaboration

2016-01-01

The ATLAS Liquid Argon (LAr) Calorimeters were designed and built to measure electromagnetic and hadronic energy in proton-proton collisions produced at the Large Hadron Collider (LHC) at centre-of-mass energies up to \\SI{14}{\\tera\\electronvolt} and instantaneous luminosities up to \\SI{d34}{\\per\\centi\\meter\\squared\\per\\second}. The High Luminosity LHC (HL-LHC) programme is now developed for up to 5-7 times the design luminosity, with the goal of accumulating an integrated luminosity of \\SI{3000}{\\per\\femto\\barn}. In the HL-LHC phase, the increased radiation levels require a replacement of the front-end (FE) electronics of the LAr Calorimeters. Furthermore, the ATLAS trigger system is foreseen to increase the trigger accept rate and the trigger latency which requires a larger data volume to be buffered. Therefore, the LAr Calorimeter read-out will be exchanged with a new FE and a high bandwidth back-end (BE) system for receiving data from all \

Design and performance of an electromagnetic calorimeter for a FCC-hh experiment

Science.gov (United States)

Zaborowska, A.

2018-03-01

The physics reach and feasibility of the Future Circular Collider are currently under investigation. The goal is to collide protons with centre-of-mass energies up to 100 TeV, extending the research carried out at the current HEP facilities. The detectors designed for the FCC experiments need to tackle harsh conditions of the unprecedented collision energy and luminosity. The baseline technology for the calorimeter system of the FCC-hh detector is described. The electromagnetic calorimeter in the barrel, as well as the electromagnetic and hadronic calorimeters in the endcaps and the forward regions, are based on the liquid argon as active material. The detector layout in the barrel region combines the concept of a high granularity calorimeter with precise energy measurements. The calorimeters have to meet the requirements of high radiation hardness and must be able to deal with a very high number of collisions per bunch crossings (pile-up). A very good energy and angular resolution for a wide range of electrons' and photons' momentum is needed in order to meet the demands based on the physics benchmarks. First results of the performance studies with the new liquid argon calorimeter are presented, meeting the energy resolution goal.

The nTOF Total Absorption Calorimeter for neutron capture measurements at CERN

International Nuclear Information System (INIS)

Guerrero, C.; Abbondanno, U.; Aerts, G.; Alvarez, H.; Alvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Audouin, L.; Badurek, G.; Baumann, P.; Becvar, F.; Berthoumieux, E.; Calvino, F.; Calviani, M.; Cano-Ott, D.; Capote, R.; Carrapico, C.; Cennini, P.; Chepel, V.

2009-01-01

The n T OF Collaboration has built and commissioned a high-performance detector for (n,γ) measurements called the Total Absorption Calorimeter (TAC). The TAC was especially designed for measuring neutron capture cross-sections of low-mass and/or radioactive samples with the accuracy required for nuclear technology and stellar nucleosynthesis. We present a detailed description of the TAC and discuss its overall performance in terms of energy and time resolution, background discrimination, detection efficiency and neutron sensitivity.

Calorimeter measures high nuclear heating rates and their gradients across a reactor test hole

Science.gov (United States)

Burwell, D.; Coombe, J. R.; Mc Bride, J.

1970-01-01

Pedestal-type calorimeter measures gamma-ray heating rates from 0.5 to 7.0 watts per gram of aluminum. Nuclear heating rate is a function of cylinder temperature change, measured by four chromel-alumel thermocouples attached to the calorimeter, and known thermoconductivity of the tested material.

Microfluidic Air Sampler for Highly Efficient Bacterial Aerosol Collection and Identification.

Science.gov (United States)

Bian, Xiaojun; Lan, Ying; Wang, Bing; Zhang, Yu Shrike; Liu, Baohong; Yang, Pengyuan; Zhang, Weijia; Qiao, Liang

2016-12-06

The early warning capability of the presence of biological aerosol threats is an urgent demand in ensuing civilian and military safety. Efficient and rapid air sample collection in relevant indoor or outdoor environment is a key step for subsequent analysis of airborne microorganisms. Herein, we report a portable battery-powered sampler that is capable of highly efficient bioaerosol collection. The essential module of the sampler is a polydimethylsiloxane (PDMS) microfluidic chip, which consisted of a 3-loop double-spiral microchannel featuring embedded herringbone and sawtooth wave-shaped structures. Vibrio parahemolyticus (V. parahemolyticus) as a model microorganism, was initially employed to validate the bioaerosol collection performance of the device. Results showed that the sampling efficacy reached as high as >99.9%. The microfluidic sampler showed greatly improved capturing efficiency compared with traditional plate sedimentation methods. The high performance of our device was attributed to the horizontal inertial centrifugal force and the vertical turbulence applied to airflow during sampling. The centrifugation field and turbulence were generated by the specially designed herringbone structures when air circulated in the double-spiral microchannel. The sawtooth wave-shaped microstructure created larger specific surface area for accommodating more aerosols. Furthermore, a mixture of bacterial aerosols formed by V. parahemolyticus, Listeria monocytogenes, and Escherichia coli was extracted by the microfluidic sampler. Subsequent integration with mass spectrometry conveniently identified the multiple bacterial species captured by the sampler. Our developed stand-alone and cable-free sampler shows clear advantages comparing with conventional strategies, including portability, easy-to-use, and low cost, indicating great potential in future field applications.

Construction and beam-tests of silicon-tungsten prototype modules for the CMS High Granularity Calorimeter for HL-LHC

Science.gov (United States)

Quast, Thorben

2018-02-01

As part of its HL-LHC upgrade program, CMS is developing a High Granularity Calorimeter (HGCAL) to replace the existing endcap calorimeters. The HGCAL will be realised as a sampling calorimeter, including an electromagnetic compartment comprising 28 layers of silicon pad detectors with pad areas of 0.5-1.0 cm2 interspersed with absorbers. Prototype modules, based on 6-inch hexagonal silicon pad sensors with 128 channels, have been constructed and include many of the features required for this challenging detector. In 2016, beam tests of sampling configurations made from these modules have been conducted both at FNAL and at CERN using the Skiroc2 front-end ASIC (designed by the CALICE collaboration for ILC). In 2017, the setup has been extended with CALICE's AHCAL prototype, a scinitillator based sampling calorimeter, and it was further tested in dedicated beam tests at CERN. There, the new Skiroc2-CMS front-end ASIC was used for the first time. We highlight final results from our studies in 2016, including position resolution as well as precision timing-measurements. Furthermore, the extended setup in 2017 is discussed and first results from beam tests with electrons and pions are shown.

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

Directory of Open Access Journals (Sweden)

Bee Luan Khoo

Full Text Available Circulating tumor cells (CTCs are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to provide critical information for guiding cancer treatment. Current analysis of CTCs is hindered by the throughput, selectivity and specificity of devices or assays used in CTC detection and isolation.Here, we enriched and characterized putative CTCs from blood samples of patients with both advanced stage metastatic breast and lung cancers using a novel multiplexed spiral microfluidic chip. This system detected putative CTCs under high sensitivity (100%, n = 56 (Breast cancer samples: 12-1275 CTCs/ml; Lung cancer samples: 10-1535 CTCs/ml rapidly from clinically relevant blood volumes (7.5 ml under 5 min. Blood samples were completely separated into plasma, CTCs and PBMCs components and each fraction were characterized with immunophenotyping (Pan-cytokeratin/CD45, CD44/CD24, EpCAM, fluorescence in-situ hybridization (FISH (EML4-ALK or targeted somatic mutation analysis. We used an ultra-sensitive mass spectrometry based system to highlight the presence of an EGFR-activating mutation in both isolated CTCs and plasma cell-free DNA (cf-DNA, and demonstrate concordance with the original tumor-biopsy samples.We have clinically validated our multiplexed microfluidic chip for the ultra high-throughput, low-cost and label-free enrichment of CTCs. Retrieved cells were unlabeled and viable, enabling potential propagation and real-time downstream analysis using next generation sequencing (NGS or proteomic analysis.

Chemical calibration of Isothermal Titration Calorimeters: An evaluation of the dilution of propan-1-ol into water as a test reaction using different calorimeters, concentrations, and temperatures

International Nuclear Information System (INIS)

Adão, Regina; Bai, Guangyue; Loh, Watson; Bastos, Margarida

2012-01-01

Highlights: ► We address the importance of test reactions in Isothermal Titration Calorimetry. ► We re-evaluate a test reaction and provide a new value for it at 308.15 K. ► Different concentrations are tested to account for instrument sensitivity. ► We compare the performance of two very sensitive calorimeters of different design. ► We suggest appropriate experimental conditions for the use of this test reaction. - Abstract: The use of a good chemical calibration or test reaction in Isothermal Titration Calorimetry is crucial for getting reliable enthalpy values that can be compared across different laboratories. Indeed most titration calorimeters are used to measure both equilibrium constants and molar enthalpies of reaction. But a necessary prerequisite for such measurements is to first perform the enthalpy measurement accurately and precisely. The values of the equilibrium constant(s) are then calculated by regression from an appropriate model. As such, we found it timely to extensively test a previously proposed test reaction, the dilution of propan-1-ol into water, using two calorimeters of different design (heat conduction and power compensation calorimeters) and sensitivity. Experiments were performed at 298.15 K for the previously suggested 10% mass fraction propan-1-ol solution, as well as for the lower concentrations of 5% and 2% mass fractions. Due to our capacity to use insertion heaters with one of the used calorimeters, which allows for very accurate calibration constants to be obtained, we also determined a value for the enthalpy of dilution of 10% mass fraction solution at 308.15 K, previously not available, and closer to the temperatures commonly used in titration experiments involving biological samples. The observed change in the enthalpy of dilution was found to decrease in absolute value, but to an extent that did not justify the determination of new values for the less concentrated solutions. The values obtained with the two

Comparison between calorimeter and HLNC errors

International Nuclear Information System (INIS)

Goldman, A.S.; De Ridder, P.; Laszlo, G.

1991-01-01

This paper summarizes an error analysis that compares systematic and random errors of total plutonium mass estimated for high-level neutron coincidence counter (HLNC) and calorimeter measurements. This task was part of an International Atomic Energy Agency (IAEA) study on the comparison of the two instruments to determine if HLNC measurement errors met IAEA standards and if the calorimeter gave ''significantly'' better precision. Our analysis was based on propagation of error models that contained all known sources of errors including uncertainties associated with plutonium isotopic measurements. 5 refs., 2 tabs

A Compact Microwave Microfluidic Sensor Using a Re-Entrant Cavity.

Science.gov (United States)

Hamzah, Hayder; Abduljabar, Ali; Lees, Jonathan; Porch, Adrian

2018-03-19

A miniaturized 2.4 GHz re-entrant cavity has been designed, manufactured and tested as a sensor for microfluidic compositional analysis. It has been fully evaluated experimentally with water and common solvents, namely methanol, ethanol, and chloroform, with excellent agreement with the expected behaviour predicted by the Debye model. The sensor's performance has also been assessed for analysis of segmented flow using water and oil. The samples' interaction with the electric field in the gap region has been maximized by aligning the sample tube parallel to the electric field in this region, and the small width of the gap (typically 1 mm) result in a highly localised complex permittivity measurement. The re-entrant cavity has simple mechanical geometry, small size, high quality factor, and due to the high concentration of electric field in the gap region, a very small mode volume. These factors combine to result in a highly sensitive, compact sensor for both pure liquids and liquid mixtures in capillary or microfluidic environments.

Development of an optical simulation for the SuperNEMO calorimeter

Science.gov (United States)

Huber, Arnaud; SuperNEMO Collaboration

2017-09-01

The SuperNEMO double beta decay project is a modular tracker-calorimeter based experiment. The aim of this project is to reach a sensitivity of the order of 1026 years concerning the neutrinoless double beta decay half-life, corresponding to a Majorana neutrino mass of 50-100 meV. The main calorimeter of the SuperNEMO demonstrator is based on 520 Optical Modules made of large volume plastic scintillators (10L) coupled with large area photomultipliers (Hamamatsu R5912-MOD and R6594). The design of the calorimeter is optimized for the double beta decay detection and allows gamma tagging for background rejection. In large volumes of scintillators, a similar deposited energy by electrons or photons will give different visible energy and signal shapes due to different interactions inside the scintillator. The aim of the optical simulation, developed for SuperNEMO, is to model the Optical Module response on the energy and time performances, regarding the particle type.

Installing the ATLAS calorimeter

CERN Multimedia

Maximilien Brice

2005-01-01

The eight toroid magnets can be seen surrounding the calorimeter that is later moved into the middle of the detector. This calorimeter will measure the energies of particles produced when protons collide in the centre of the detector.

Design of highly sensitive multichannel bimetallic photonic crystal fiber biosensor

Science.gov (United States)

Hameed, Mohamed Farhat O.; Alrayk, Yassmin K. A.; Shaalan, Abdelhamid A.; El Deeb, Walid S.; Obayya, Salah S. A.

2016-10-01

A design of a highly sensitive multichannel biosensor based on photonic crystal fiber is proposed and analyzed. The suggested design has a silver layer as a plasmonic material coated by a gold layer to protect silver oxidation. The reported sensor is based on detection using the quasi transverse electric (TE) and quasi transverse magnetic (TM) modes, which offers the possibility of multichannel/multianalyte sensing. The numerical results are obtained using a finite element method with perfect matched layer boundary conditions. The sensor geometrical parameters are optimized to achieve high sensitivity for the two polarized modes. High-refractive index sensitivity of about 4750 nm/RIU (refractive index unit) and 4300 nm/RIU with corresponding resolutions of 2.1×10-5 RIU, and 2.33×10-5 RIU can be obtained according to the quasi TM and quasi TE modes of the proposed sensor, respectively. Further, the reported design can be used as a self-calibration biosensor within an unknown analyte refractive index ranging from 1.33 to 1.35 with high linearity and high accuracy. Moreover, the suggested biosensor has advantages in terms of compactness and better integration of microfluidics setup, waveguide, and metallic layers into a single structure.

High-pressure needle interface for thermoplastic microfluidics.

Science.gov (United States)

Chen, C F; Liu, J; Hromada, L P; Tsao, C W; Chang, C C; DeVoe, D L

2009-01-07

A robust and low dead volume world-to-chip interface for thermoplastic microfluidics has been developed. The high pressure fluidic port employs a stainless steel needle inserted into a mating hole aligned to an embedded microchannel, with an interference fit used to increase pressure resistance. Alternately, a self-tapping threaded needle screwed into a mating hole is also demonstrated. In both cases, the flat bottom needle ports seat directly against the microchannel substrate, ensuring low interfacial dead volumes. Low dispersion is observed for dye bands passing the interfaces. The needle ports offer sufficient pull-out forces for applications such as liquid chromatography that require high internal fluid pressures, with the epoxy-free interfaces compatible with internal microchannel pressures above 40 MPa.

The new ATLAS Fast Calorimeter Simulation

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00223142; The ATLAS collaboration

2017-01-01

Current and future need for large scale simulated samples motivate the development of reliable fast simulation techniques. The new Fast Calorimeter Simulation is an improved parameterized response of single particles in the ATLAS calorimeter that aims to accurately emulate the key features of the detailed calorimeter response as simulated with Geant4, yet approximately ten times faster. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. A prototype of this new Fast Calorimeter Simulation is in development and its integration into the ATLAS simulation infrastructure is ongoing.

The new ATLAS Fast Calorimeter Simulation

Science.gov (United States)

Schaarschmidt, J.; ATLAS Collaboration

2017-10-01

Current and future need for large scale simulated samples motivate the development of reliable fast simulation techniques. The new Fast Calorimeter Simulation is an improved parameterized response of single particles in the ATLAS calorimeter that aims to accurately emulate the key features of the detailed calorimeter response as simulated with Geant4, yet approximately ten times faster. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. A prototype of this new Fast Calorimeter Simulation is in development and its integration into the ATLAS simulation infrastructure is ongoing.

Detection and classification of ebola on microfluidic chips

Science.gov (United States)

Lin, Xue; Jin, Xiangyu; Fan, Yunqian; Huang, Qin; Kou, Yue; Zu, Guo; Huang, Shiguang; Liu, Xiaosheng; Huang, Guoliang

2016-10-01

Point-of-care testing (POCT) for an infectious diseases is the prerequisite to control of the disease and limitation of its spread. A microfluidic chip for detection and classification of four strains of Ebola virus was developed and evaluated. This assay was based on reverse transcription loop-mediated isothermal amplification (RT-LAMP) and specific primers for Ebola Zaire virus, Ebola Sudan virus, Ebola Tai Forest virus and Ebola Bundibugyo virus were designed. The sensitivity of the microfluidic chip was under 103 copies per milliliter, as determined by ten repeated tests. This assay is unique in its ability to enable diagnosis of the Ebola infections and simultaneous typing of Ebola virus on a single chip. It offers short reaction time, ease of use and high specificity. These features should enable POCT in remote area during outbreaks of Ebola virus.

A High Granularity Timing Detector for the Phase-2 Upgrade of the ATLAS Calorimeter

CERN Document Server

Grinstein, Sebastian; The ATLAS collaboration

2017-01-01

The expected increase of the particle flux at the high luminosity phase of the LHC with instantaneous luminosities up to L ≃ 7.5 × 10^{34} cm^{−2} s^{−1} will have a severe impact on pile-up. The pile-up is expected to increase on average to 200 interactions per bunch crossing. The reconstruction and trigger performance for especially jets and transverse missing energy will be severely degraded in the end-cap and forward region. A High Granularity Timing Detector (HGTD) is proposed in front of the liquid Argon end-cap calorimeters for pile-up mitigation at Level-0 (L0) trigger level and in the offline reconstruction. This device cover the pseudo-rapidity range of 2.4 to about 4.2. Four layers of Silicon sensors, possibly interleaved with Tungsten, are foreseen to provide precision timing information for charged and neutral particles with a time resolution of the order of 30 pico-seconds per readout cell in order to assign the energy deposits in the calorimeter to different proton-proton collision verti...

Construction of the Zeus forward/rear calorimeter modules at NIKHEF

International Nuclear Information System (INIS)

Blankers, R.; Engelen, J.; Geerinck, H.; Homma, J.; Hunck, P.; Koning, N. de; Kooijman, P.; Korporaal, A.; Loos, R.; Straver, J.; Tiecke, H.

1990-07-01

ZEUS is one of the two experiments in preparation for studying electron-proton interactions at the HERA e-p collider at DESY in Hamburg. The design value for the energy of the electron beam is 30 GeV and for the proton beam 820 GeV. The asymmetry in the beam particle masses and their energies causes in general a strongly asymmetric energy distribution for the reaction products, in particular most of the energy flow will be in the proton direction. The layout of the ZEUS detector accomodates for this asymmetry. In the proton direction for instance, several wirechambers assure together with the central tracking detector good track reconstruction, in an area where high density of tracks is expected. The tracking detector is placed inside a magnetic field of 1.8 Tesla, provided by a superconducting coil. The interaction point is completely surrounded by a high resolution calorimeter, which in turn is surrounded by a backing calorimeter; this backing calorimeter has to detect late showering particles, has to serve as a muon filter and is also the return yoke for the magnetic field. The ZEUS collaboration has chosen for a type of hadron calorimeter with the best possible energy resolution known to date, a depleted uranium-scintillator sampling calorimeter. The calorimeter has an equal response to electrons and hadrons of the same energy (e/h=1). The sampling thickness is one radiation length. The calorimeter is subdivided in three components, the forward- (in proton direction), the rear- (in electron direction) and the barrel calorimeter, FCAL, RCAL and BCAL. In this report the design and assembly procedure of the FCAL/RCAL is described in detail. Furthermore the transport problems are discussed and the first calibration results obtained with beam particles are shown. (author). 5 refs.; 29 figs.; 1 tab

Dye-sensitized solar cell module realized photovoltaic and photothermal highly efficient conversion via three-dimensional printing technology

International Nuclear Information System (INIS)

Huang Qi-Zhang; Zhu Yan-Qing; Shi Ji-Fu; Wang Lei-Lei; Zhong Liu-Wen; Xu Gang

2017-01-01

Three-dimensional (3D) printing technology is employed to improve the photovoltaic and photothermal conversion efficiency of dye-sensitized solar cell (DSC) module. The 3D-printed concentrator is optically designed and improves the photovoltaic efficiency of the DSC module from 5.48% to 7.03%. Additionally, with the 3D-printed microfluidic device serving as water cooling, the temperature of the DSC can be effectively controlled, which is beneficial for keeping a high photovoltaic conversion efficiency for DSC module. Moreover, the 3D-printed microfluidic device can realize photothermal conversion with an instantaneous photothermal efficiency of 42.1%. The integrated device realizes a total photovoltaic and photothermal conversion efficiency of 49% at the optimal working condition. (paper)

Indirect measurement of the magnetocaloric effect using a novel differential scanning calorimeter with magnetic field.

Science.gov (United States)

Jeppesen, S; Linderoth, S; Pryds, N; Kuhn, L Theil; Jensen, J Buch

2008-08-01

A simple and high-sensitivity differential scanning calorimeter (DSC) unit operating under magnetic field has been built for indirect determination of the magnetocaloric effect. The principle of the measuring unit in the calorimeter is based on Peltier elements as heat flow sensors. The high sensitivity of the apparatus combined with a suitable calibration procedure allows very fast and accurate heat capacity measurements under magnetic field to be made. The device was validated from heat capacity measurements for the typical DSC reference material gallium (Ga) and a La(0.67)Ca(0.33)MnO(3) manganite system and the results were highly consistent with previous reported data for these materials. The DSC has a working range from 200 to 340 K and has been tested in magnetic fields reaching 1.8 T. The signal-to-noise ratio is in the range of 10(2)-10(3) for the described experiments. Finally the results have been compared to results from a Quantum Design(R) physical properties measuring system. The configuration of the system also has the advantage of being able to operate with other types of magnets, e.g., permanent magnets or superconducting coils, as well as the ability to be expanded to a wider temperature range.

Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI

Science.gov (United States)

Ledbetter, Micah P [Oakland, CA; Savukov, Igor M [Los Alamos, NM; Budker, Dmitry [El Cerrito, CA; Shah, Vishal K [Plainsboro, NJ; Knappe, Svenja [Boulder, CO; Kitching, John [Boulder, CO; Michalak, David J [Berkeley, CA; Xu, Shoujun [Houston, TX; Pines, Alexander [Berkeley, CA

2011-08-09

An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.

Development of a metallic magnetic calorimeter for high resolution spectroscopy; Entwicklung eines metallischen magnetischen Kalorimeters fuer die hochaufloesende Roentgenspektroskopie

Energy Technology Data Exchange (ETDEWEB)

Linck, M.

2007-05-02

In this thesis the development of a metallic magnetic calorimeter for high resolution detection of single x-ray quanta is described. The detector consists of an X-ray absorber and a paramagnetic temperature sensor. The raise in temperature of the paramagnetic sensor due to the absorption of a single X-ray is measured by the change in magnetization of the sensor using a low-noise SQUID magnetometer. The thermodynamic properties of the detector can be described by a theoretical model based on a mean field approximation. This allows for an optimization of the detector design with respect to signal size. The maximal archivable energy resolution is limited by thermodynamic energy fluctuations between absorber, heat bath and thermometer. An interesting field of application for a metallic magnetic calorimeter is X-ray astronomy and the investigation of X-ray emitting objects. Through high-resolution X-ray spectroscopy it is possible to obtain information about physical processes of even far distant objects. The magnetic calorimeter that was developed in this thesis has a metallic absorber with a quantum efficiency of 98% at 6 keV. The energy resolution of the magnetic calorimeter is EFWHM=2.7 eV at 5.9 keV. The deviation of the detector response from a linear behavior of the detector is only 0.8% at 5.9 keV. (orig.)

Microfluidic production of polymeric functional microparticles

Science.gov (United States)

Jiang, Kunqiang

This dissertation focuses on applying droplet-based microfluidics to fabricate new classes of polymeric microparticles with customized properties for various applications. The integration of microfluidic techniques with microparticle engineering allows for unprecedented control over particle size, shape, and functional properties. Specifically, three types of microparticles are discussed here: (1) Magnetic and fluorescent chitosan hydrogel microparticles and their in-situ assembly into higher-order microstructures; (2) Polydimethylsiloxane (PDMS) microbeads with phosphorescent properties for oxygen sensing; (3) Macroporous microparticles as biological immunosensors. First, we describe a microfluidic approach to generate monodisperse chitosan hydrogel microparticles that can be further connected in-situ into higher-order microstructures. Microparticles of the biopolymer chitosan are created continuously by contacting an aqueous solution of chitosan at a microfluidic T-junction with a stream of hexadecane containing a nonionic detergent, followed by downstream crosslinking of the generated droplets by a ternary flow of glutaraldehyde. Functional properties of the microparticles can be easily varied by introducing payloads such as magnetic nanoparticles and/or fluorescent dyes into the chitosan solution. We then use these prepared microparticles as "building blocks" and assemble them into high ordered microstructures, i.e. microchains with controlled geometry and flexibility. Next, we describe a new approach to produce monodisperse microbeads of PDMS using microfluidics. Using a flow-focusing configuration, a PDMS precursor solution is dispersed into microdroplets within an aqueous continuous phase. These droplets are collected and thermally cured off-chip into soft, solid microbeads. In addition, our technique allows for direct integration of payloads, such as an oxygen-sensitive porphyrin dye, into the PDMS microbeads. We then show that the resulting dye

Performance of a Highly Granular Scintillator-SiPM Based Hadron Calorimeter Prototype in Strong Magnetic Fields

OpenAIRE

Graf, Christian; collaboration, for the CALICE

2017-01-01

Within the CALICE collaboration, several concepts for the hadronic calorimeter of a future linear collider detector are studied. After having demonstrated the capabilities of the measurement methods in "physics prototypes", the focus now lies on improving their implementation in "engineering prototypes", that are scalable to the full linear collider detector. The Analog Hadron Calorimeter (AHCAL) concept is a sampling calorimeter of tungsten or steel absorber plates and plastic scintillator t...

Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing

Directory of Open Access Journals (Sweden)

Yaowen Liu

2016-11-01

Full Text Available A new method to integrate poly-dl-lactide (PLA patterned electrospun fibers with a polydimethylsiloxane (PDMS microfluidic chip was successfully developed via lithography. Hepatocyte behavior under static and dynamic conditions was investigated. Immunohistochemical analyses indicated good hepatocyte survival under the dynamic culture system with effective hepatocyte spheroid formation in the patterned microfluidic chip vs. static culture conditions and tissue culture plate (TCP. In particular, hepatocytes seeded in this microfluidic chip under a flow rate of 10 μL/min could re-establish hepatocyte polarity to support biliary excretion and were able to maintain high levels of albumin and urea secretion over 15 days. Furthermore, the optimized system could produce sensitive and consistent responses to nano-Ag-induced hepatotoxicity during culture. Thus, this microfluidic chip device provides a new means of fabricating complex liver tissue-engineered scaffolds, and may be of considerable utility in the toxicity screening of nanoparticles.

OPAL detector electromagnetic calorimeter

CERN Multimedia

1988-01-01

Half of the electromagnetic calorimeter of the OPAL detector is seen in this photo. This calorimeter consists of 4720 blocks of lead glass. It was used to detect and measure the energy of photons, electrons and positrons by absorbing them.

The H1 liquid argon calorimeter system

International Nuclear Information System (INIS)

Andrieu, B.; Babayev, A.; Ban, J.

1993-06-01

The liquid argon calorimeter of the H1 detector presently taking data at the HERA ep - collider at DESY, Hamburg, is described here. The main physics requirements and the most salient design features relevant to this calorimeter are given. The aim to have smooth and hermetic calorimetric coverage over the polar angular range 4 ≤ θ ≤ 154 is achieved by a single liquid argon cryostat containing calorimeter stacks structured in wheels and octants for easy handling. The absorber materials used are lead in the electromagnetic part and stainless steel in the hadronic part. The read-out system is pipelined to reduce the dead time induced by the high trigger rate expected at the HERA collider where consecutive bunches are separated in time by 96 ns. The main elements of the calorimeter, such as the cryostat, with its associated cryogenics, the stack modules, the read-out, calibration and trigger electronics as well as the data acquisition system are described. Performance results from data taken in calibration runs with full size H1 calorimeter stacks at a CERN test beam, as well as results from data collected with the complete H1 detector using cosmic rays during the initial phase of ep operations are presented. The observed energy resolutions and linearities are well in agreement with the requirements. (orig.)

Calibration of the ZEUS forward calorimeter

International Nuclear Information System (INIS)

Kraemer, M.

1990-10-01

The physics at the ep-collider HERA requires high resolution calorimetry calibrated with an accuracy of better than 2%. The ZEUS detector meets these conditions by means of a compensating uranium scintillator sandwich calorimeter with an energy resolution of σ/E = 35%/√E + σ cal , where σ cal is the calibration error. One of the tools to minimize σ cal is the calibration with the signals of the radioactivity of the Uranium plates (UNO). Taking UNO data every 8 hours keeps the calibration stable within ≅ 1%. The muon calibration is done employing an algorithm, that determines the most probable energy loss with a precision of ≅ 1%. The channel-to-channel fluctuations of the ratio μ/UNO for a forward calorimeter (FCAL) prototype show a spread of 5.2% for the electromagnetic calorimeter and ≅ 2.5% for the hadronic sections. Improvements in the construction of the FCAL modules decreased these fluctuations to 2.0% and ≅ 1.8% respectively. The influence of the cracks between the calorimeter modules amounts to ≅ 1.7% on average for the ZEUS geometry, if a 2 mm thick Pb-sheet is introduced between the modules. We conclude that we are able to keep σ cal below 2%. (orig.)

Principles, Techniques, and Applications of Tissue Microfluidics

Science.gov (United States)

Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

2011-01-01

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called "tissue microfluidics" because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets.

Last fibre for the CMS's forward hadronic calorimeter

CERN Multimedia

2004-01-01

In February an important milestone was passed by the CMS's forward hadronic calorimeter project: the last of 450000 quartz fibres was inserted and the wedge preparation phase has now been completed. Ten thousand working hours were spent on inserting 450 000 quartz fibres into the CMS's forward hadronic calorimeter! Patience and meticulous attention to detail were the two qualities required by the five people who undertook this special job at CERN. On 6 February their task was completed. "The CMS's forward hadronic calorimeter (HF) covers the region immediately close to the LHC beam, 0.6 degrees to 6 degrees from the beam line," explains project coordinator Tiziano Camporesi. The detection of high energy jets in this angular region will be very important in helping to identify the signature of the Higgs boson or possibly any new boson produced in proton-proton collision in the LHC. Rita Fodor, 19, is working on one wedge of the CMS's forward hadronic calorimeter in building 186. She and her...

The time structure of hadronic showers in highly granular calorimeters with tungsten and steel absorbers

Czech Academy of Sciences Publication Activity Database

Adloff, C.; Blaising, J.J.; Chefdeville, M.; Cvach, Jaroslav; Gallus, Petr; Havránek, Miroslav; Janata, Milan; Kvasnička, Jiří; Lednický, Denis; Marčišovský, Michal; Polák, Ivo; Popule, Jiří; Tomášek, Lukáš; Tomášek, Michal; Růžička, Pavel; Šícho, Petr; Smolík, Jan; Vrba, Václav; Zálešák, Jaroslav

2014-01-01

Roč. 9, Jul (2014), s. 1-24 ISSN 1748-0221 R&D Projects: GA MŠk LG14033 Institutional support: RVO:68378271 Keywords : hadronic calorimeter s * hadronic showers * hadronic physics models * hilicon photomultiplier Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.399, year: 2014

High-voltage test and training of plastic streamer tubes for the DELPHI hadron calorimeter

International Nuclear Information System (INIS)

Alekseev, G.D.; Cellar, S.; Khomenko, B.A.; Korytov, A.V.; Kulinich, P.A.; Micelmacher, G.V.; Sedykh, Yu.V.; Toledo, R.

1987-01-01

The results of high-voltage test and training of plastic streamer tubes of the DELPHI hadron calorimeter are presented. The testing technique is considered in detail. The equipment for high-voltage training consists of a mini-computer, CAMAC-electronics, a controllable high-voltage supply and a digital ampermeter. The experimental results shows that high-voltage training of streamer tubes improves their characteristics. The value of dark current decreased up to 1 μA. The operational voltage range increased by a value more than 300 V

Design, Construction and Installation of the ATLAS Hadronic Barrel Scintillator-Tile Calorimeter

CERN Document Server

Abdallah, J; Alexa, C; Alves, R; Amaral, P; Ananiev, A; Anderson, K; Andresen, X; Antonaki, A; Batusov, V; Bednar, P; Bergeaas, E; Biscarat, C; Blanch, O; Blanchot, G; Bohm, C; Boldea, V; Bosi, F; Bosman, M; Bromberg, C; Budagov, Yu A; Calvet, D; Cardeira, C; Carli, T; Carvalho, J; Cascella, M; Castillo, M V; Costello, J; Cavalli-Sforza, M; Cavasinni, V; Cerqueira, A S; Clément, C; Cobal, M; Cogswell, F; Constantinescu, S; Costanzo, D; Da Silva, P; Davidek, M; David, T; Dawson, J; De, K; Del Prete, T; Di Girolamo, B; Dita, S; Dolejsi, J; Dolezal, Z; Dotti, A; Downing, R; Drake, G; Efthymiopoulos, I; Errede, D; Errede, S; Farbin, A; Fassouliotis, D; Feng, E; Fenyuk, A; Ferdi, C; Ferreira, B C; Ferrer, A; Flaminio, V; Flix, J; Francavilla, P; Fullana, E; Garde, V; Gellerstedt, K; Giakoumopoulou, V; Giangiobbe, V; Gildemeister, O; Gilewsky, V; Giokaris, N; Gollub, N; Gomes, A; González, V; Gouveia, J; Grenier, P; Gris, P; Guarino, V; Guicheney, C; Sen-Gupta, A; Hakobyan, H; Haney, M; Hellman, S; Henriques, A; Higón, E; Hill, N; Holmgren, S; Hruska, I; Hurwitz, M; Huston, J; Jen-La Plante, I; Jon-And, K; Junk, T; Karyukhin, A; Khubua, J; Klereborn, J; Kopikov, S; Korolkov, I; Krivkova, P; Kulchitsky, Y; Kurochkin, Yu; Kuzhir, P; Lapin, V; Le Compte, T; Lefèvre, R; Leitner, R; Li, J; Liablin, M; Lokajícek, M; Lomakin, Y; Lourtie, P; Lovas, L; Lupi, A; Maidantchik, C; Maio, A; Maliukov, S; Manousakis, A; Marques, C; Marroquim, F; Martin, F; Mazzoni, E; Merritt, F S; Myagkov, A; Miller, R; Minashvili, I; Miralles, L; Montarou, G; Némécek, S; Nessi, M; Nikitine, I; Nodulman, L; Norniella, O; Onofre, A; Oreglia, M; Palan, B; Pallin, D; Pantea, D; Pereira, A; Pilcher, J E; Pina, J; Pinhão, J; Pod, E; Podlyski, F; Portell, X; Poveda, J; Pribyl, L; Price, L E; Proudfoot, J; Ramalho, M; Ramstedt, M; Raposeiro, L; Reis, J; Richards, R; Roda, C; Romanov, V; Rosnet, P; Roy, P; Ruiz, A; Rumiantsau, V; Russakovich, N; Sada Costa, J; Salto, O; Salvachúa, B; Sanchis, E; Sanders, H; Santoni, C; Santos, J; Saraiva, J G; Sarri, F; Says, L P; Schlager, G; Schlereth, J L; Seixas, J M; Selldén, B; Shalanda, N; Shevtsov, P; Shochet, M; Simaitis, V; Simonyan, M; Sisakian, A; Sjölin, J; Solans, C; Solodkov, A; Solovianov, J; Silva, O; Sosebee, M; Spanó, F; Speckmeyer, P; Stanek, R; Starchenko, E; Starovoitov, P; Suk, M; Sykora, I; Tang, F; Tas, P; Teuscher, R; Tokar, S; Topilin, N; Torres, J; Underwood, D; Usai, G; Valero, A; Valkár, S; Valls, J A; Vartapetian, A; Vazeille, F; Vellidis, C; Ventura, F; Vichou, I; Vivarelli, I; Volpi, M; White, A; Zaitsev, A; Zenin, A; Zenis, T; Zenonos, Z; Zenz, S; Zilka, B

2007-01-01

The scintillator tile hadronic calorimeter is a sampling calorimeter using steel as the absorber structure and scintillator as the active medium. The scintillator is located in "pockets" in the steel structure and the wavelength-shifting fibers are contained in channels running radially within the absorber to photomultiplier tubes which are located in the outer support girders of the calorimeter structure. In addition, to its role as a detector for high energy particles, the tile calorimeter provides the direct support of the liquid argon electromagnetic calorimeter in the barrel region, and the liquid argon electromagnetic and hadronic calorimeters in the endcap region. Through these, it indirectly supports the inner tracking system and beam pipe. The steel absorber, and in particular the support girders, provide the flux return for the solenoidal field from the central solenoid. Finally, the end surfaces of the barrel calorimeter are used to mount services, power supplies and readout crates for the inner tr...

A high-granularity scintillator hadronic-calorimeter with SiPM readout for a linear collider detector

International Nuclear Information System (INIS)

Andreev, V.; Balagura, V; Bobchenko, B.

2004-01-01

We report upon the design, construction and operation of a prototype for a high-granularity tile hadronic calorimeter for a future international linear collider(ILC) detector. Scintillating tiles are read out via wavelength-shifting fibers which guides the scintillation light to a novel photodetector, the Silicon Photomultiplier. The prototype has been tested at DESY using a positron test beam. The results are compared with a reference prototype equipped with multichannel vacuum photomultipliers. Detector calibration, noise, linearity and stability are discussed, and the energy response in a 1-6 GeV positron beam is compared with simulation. The work presented serves to establish the application of SiPM for calorimetry, and leads to the choice of this device for the construction of a 1m 3 calorimeter prototype for tests in hadron beams. (orig.)

Applications of Microfluidics in Quantitative Biology.

Science.gov (United States)

Bai, Yang; Gao, Meng; Wen, Lingling; He, Caiyun; Chen, Yuan; Liu, Chenli; Fu, Xiongfei; Huang, Shuqiang

2018-05-01

Quantitative biology is dedicated to taking advantage of quantitative reasoning and advanced engineering technologies to make biology more predictable. Microfluidics, as an emerging technique, provides new approaches to precisely control fluidic conditions on small scales and collect data in high-throughput and quantitative manners. In this review, the authors present the relevant applications of microfluidics to quantitative biology based on two major categories (channel-based microfluidics and droplet-based microfluidics), and their typical features. We also envision some other microfluidic techniques that may not be employed in quantitative biology right now, but have great potential in the near future. © 2017 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. Biotechnology Journal Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Ultrasensitive microfluidic solid-phase ELISA using an actuatable microwell-patterned PDMS chip.

Science.gov (United States)

Wang, Tanyu; Zhang, Mohan; Dreher, Dakota D; Zeng, Yong

2013-11-07

Quantitative detection of low abundance proteins is of significant interest for biological and clinical applications. Here we report an integrated microfluidic solid-phase ELISA platform for rapid and ultrasensitive detection of proteins with a wide dynamic range. Compared to the existing microfluidic devices that perform affinity capture and enzyme-based optical detection in a constant channel volume, the key novelty of our design is two-fold. First, our system integrates a microwell-patterned assay chamber that can be pneumatically actuated to significantly reduce the volume of chemifluorescent reaction, markedly improving the sensitivity and speed of ELISA. Second, monolithic integration of on-chip pumps and the actuatable assay chamber allow programmable fluid delivery and effective mixing for rapid and sensitive immunoassays. Ultrasensitive microfluidic ELISA was demonstrated for insulin-like growth factor 1 receptor (IGF-1R) across at least five orders of magnitude with an extremely low detection limit of 21.8 aM. The microwell-based solid-phase ELISA strategy provides an expandable platform for developing the next-generation microfluidic immunoassay systems that integrate and automate digital and analog measurements to further improve the sensitivity, dynamic ranges, and reproducibility of proteomic analysis.

ATLAS Calorimeters: Run-2 performance and Phase-II upgrade

CERN Document Server

Boumediene, Djamel Eddine; The ATLAS collaboration

2017-01-01

The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 10^{34} cm^{−2} s^{−1}. A liquid argon (LAr)-lead sampling calorimeter is employed as electromagnetic calorimeter and hadronic calorimter, except in the barrel region, where a scintillator-steel sampling calorimeter (TileCal) is used as hadronic calorimter. This presentation will give first an overview of the detector operation and data quality, as well as the achieved performance of the ATLAS calorimetry system. Additionally, the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC) will be presented. For the HL-LHC, the instantaneous luminosity is expected to increase up to L ≃ 7.5 × 10^{34} cm^{−2} s^{−1} and the average pile-up up to 200 interactions per bunch crossing. The major R&D item is the upgrade of the electronics for both LAr and Tile calorimeters in order to cope wit...

A high granularity scintillator hadronic — calorimeter with SiPM readout for a linear collider detector

Czech Academy of Sciences Publication Activity Database

Andreev, V.; Balagura, V.; Bobchenko, B.; Cvach, Jaroslav; Janata, Milan; Kacl, Ivan; Němeček, Stanislav; Polák, Ivo; Valkár, Š.; Weichert, Jan; Zálešák, Jaroslav

2005-01-01

Roč. 540, - (2005), s. 368-380 ISSN 0168-9002 R&D Projects: GA MŠk(CZ) LN00A006 Institutional research plan: CEZ:AV0Z10100502 Keywords : linear collider detector * analog calorimeter * semiconductor detectors * scintillator * high granularity Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.224, year: 2005

The new ATLAS Fast Calorimeter Simulation

CERN Document Server

Hasib, Ahmed; The ATLAS collaboration

2017-01-01

Producing the very large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing CPU requirements when detailed detector simulations are not needed. During the LHC Run-1, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and it can be tuned to data more easily than GEANT4. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim makes use of statistical techniques such as principal component analysis, and a neural n...

Upgrading the ATLAS Tile Calorimeter electronics

CERN Document Server

Carrio, F; The ATLAS collaboration

2013-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the most central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. Its main upgrade will occur for the High Luminosity LHC phase (phase 2) where the luminosity will have increased 5-fold compared to the design luminosity (1034 cm−2s−1) but with maintained energy (i.e. 7+7 TeV). An additional luminosity increase by a factor of 2 can be achieved by luminosity leveling. This upgrade will probably happen around 2022. The upgrade aims at replacing the majority of the on- and off- detector electronics so that all calorimeter signals are directly digitized and sent to the off-detector electronics in the counting room. To achieve the required reliability, redundancy has been introduced at different levels. An ambitious upgrade development program is pursued studying different electronics options. Three different options are presently being investigated for the front-end electronic upgrade. Which one to u...

The New ATLAS Fast Calorimeter Simulation

CERN Document Server

Heath, Matthew Peter; The ATLAS collaboration

2017-01-01

Producing the large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing the CPU requirements when detailed detector simulations are not needed. During Run-1 of the LHC, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitisation and reconstruction software, and it can be tuned to data more easily than Geant4. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim aims to overcome some limitations of the first version by improving the description of...

Performance of the ATLAS Tile calorimeter

CERN Document Server

Bertoli, Gabriele; The ATLAS collaboration

2015-01-01

The Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for energy reconstruction of hadrons, jets, tau­particles and missing transverse energy. TileCal is a scintillator­steel sampling calorimeter and it covers the region of pseudorapidity < 1.7. The scintillation light produced in the tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized by sampling the signal every 25 ns. The TileCal front­end electronics read out the signals produced by about 10000 channels measuring energies ranging from ~30 MeV to ~2 TeV. The read­out system is responsible for reconstructing the data in real­time. The digitized signals are reconstructed with the Optimal Filtering algorithm, which computes for each channel the signal amplitude, time and quality factor at the required high rate. Each stage of the signal production from scintillation light to the signal reconstruc...

A Flexible and Highly Sensitive Piezoresistive Pressure Sensor Based on Micropatterned Films Coated with Carbon Nanotubes

Directory of Open Access Journals (Sweden)

Jia-lin Yao

2016-01-01

Full Text Available Excellent flexibility, high sensitivity, and low consumption are essential characteristics in flexible microtube pressure sensing occasion, for example, implantable medical devices, industrial pipeline, and microfluidic chip. This paper reports a flexible, highly sensitive, and ultrathin piezoresistive pressure sensor for fluid pressure sensing, whose sensing element is micropatterned films with conductive carbon nanotube layer. The flexible pressure sensor, the thickness of which is 40 ± 10 μm, could be economically fabricated by using biocompatible polydimethylsiloxane (PDMS. Experimental results show that the flexible pressure sensor has high sensitivity (0.047 kPa−1 in gas sensing and 5.6 × 10−3 kPa−1 in liquid sensing and low consumption (<180 μW, and the sensor could be used to measure the pressure in curved microtubes.

Hadron calorimeter module prototype for baryonic matter studies at Nuclotron

OpenAIRE

Gavrishchuk, O. P.; Ladygin, V. P.; Petukhov, Yu. P.; Sychkov, S. Ya

2014-01-01

The prototype of the hadron calorimeter module consisting of 66 scintillator/lead layers with the 15x15 cm^2 cross section and 5 nuclear interaction lengths has been designed and produced for the zero degree calorimeter of the BM@N experiment. The prototype has been tested with high energy muon beam of the U-70 accelerator at IHEP. The results of the beam test for different types of photo multipliers and light guides are presented. The results of the Monte-Carlo simulation of the calorimeter ...

ATLAS: last few metresfor the Calorimeter

CERN Multimedia

2005-01-01

On Friday 4th November, the ATLAS Barrel Calorimeter was moved from its assembly point at the side of the ATLAS cavern to the centre of the toroidal magnet system. The detector was finally aligned, to the precision of within a millimetre, on Wednesday 9th November. The ATLAS installation team, led by Tommi Nyman, after having positioned the Barrel Calorimeter in its final location in the ATLAS experimental cavern UX15. The Barrel Calorimeter which will absorb and measure the energy of photons, electrons and hadrons at the core of the ATLAS detector is 8.6 meters in diameter, 6.8 meters long, and weighs over 1600 Tonnes. It consists of two concentric cylindrical detector elements. The innermost comprises aluminium pressure vessels containing the liquid argon electromagnetic calorimeter and the solenoid magnet. The outermost is an assembly of 64 hadron tile calorimeter sectors. Assembled 18 meters away from its final position, the Barrel Calorimeter was relocated with the help of a railway, which allows the ...

Graphite calorimeter, the primary standard of absorbed dose at BNM-LNHB

International Nuclear Information System (INIS)

Daures, J.; Ostrowsky, A.; Chauvenet, B.

2002-01-01

The graphite calorimeter is the standard for absorbed dose to water at BNM-LNHB. The transfer from absorbed dose to graphite to absorbed dose to water is then performed by means of chemical dosimeters and ionisation chamber measurements. Therefore the quality of graphite calorimeter measurements is essential. The present graphite calorimeter is described. The characteristics of this calorimeter are pointed out. Special attention is given to the thermal feedback of the core, which is the main difference with the Domen-type calorimeter. The repeatability and reproducibility of the mean absorbed dose in the calorimeter core are presented in detail. As an example, individual measurements in the 20 MV photon beam from our Saturne 43 linac are given. The y-axis quantity is the mean absorbed dose in the core divided by the reference ionisation chamber charge. Both are normalised to the monitor ionisation chamber charge. The standard deviation (of the distribution itself) is 0.12 % for the first set of measurements performed in 1999. In 2002, for each different series, the standard deviation is 0.03%. The improvement on the 2002 standard deviation is mainly due to the change of the ionisation chamber used for the beam monitoring of the linac. Some benefit also comes from changes on the thermal control and measuring systems (nanovoltmeters, Wheatstone bridges, power supplies, determination of the measuring bridge sensitivity (V/Ω.) ). The maximum difference between the means of the three series is 0.08%. This difference is due to the variation of not only the calorimetric measurements but also of the reference ionisation chamber response, of the position of the assembly and of the monitoring of the beam. The stability of the linac (electron energy, photon beam shape) has to be very good too in order to obtain this global performance. The correction factors necessary to determine the absorbed dose to graphite at the reference point in an homogeneous phantom from the

Research and Development for a Free-Running Readout System for the ATLAS LAr Calorimeters at the High Luminosity LHC

CERN Document Server

Hils, Maximilian; The ATLAS collaboration

2015-01-01

The ATLAS Liquid Argon (LAr) Calorimeters were designed and built to measure electromagnetic and hadronic energy in proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to $10^{34} \\text{cm}^{-2} \\text{s}^{-1}$. The High Luminosity LHC (HL-LHC) programme is now developed for up to 5-7 times the design luminosity, with the goal of accumulating an integrated luminosity of $3000~\\text{fb}^{-1}$. In the HL-LHC phase, the increased radiation levels require a replacement of the front-end electronics of the LAr Calorimeters. Furthermore, the ATLAS trigger system is foreseen to increase the trigger accept rate by a factor 10 to 1 MHz and the trigger latency by a factor of 20 which requires a larger data volume to be buffered. Therefore, the LAr Calorimeter read-out will be exchanged with a new front-end and a high bandwidth back-end system for receiving data from all 186.000 channels at 40 MHz LHC bunch-crossing frequency and for off-detector buffering...

Some possible improvements in scintillation calorimeters

International Nuclear Information System (INIS)

Lorenz, E.

1985-03-01

Two ideas for improvements of scintillation calorimeters will be presented: a) improved readout of scintillating, totally active electromagnetic calorimeters with combinations of silicon photodiodes and fluorescent panel collectors, b) use of time structure analysis on calorimetry, both for higher rate applications and improved resolution for hadron calorimeters. (orig.)

An instant dose obtainable in situ calorimeter

International Nuclear Information System (INIS)

Kubo, H.; Mento, D.

1984-01-01

The development of a computer-linked water calorimeter is described. The advantages of this system are twofold: (i) instant dose determination is possible; and (ii) the calorimeter operation is much simpler than conventional null balance techniques. The entire calorimeter measurement procedure from the set-up to the dose determination for 10 runs was finished in approximately 2 1/2 h. A smaller calorimeter which could be kept in the treatment room for equilibrium, should permit further reduction of the time. The use of a smaller, portable computer would allow local data taking and analysis, eliminating the need for modems, phone lines and long cables. This would lead to a completely self-contained set-up at the treatment room. Although the technique is described for a polystyrene-water calorimeter, it should be equally applicable for a water calorimeter as well as a conventional isolated calorimeter. (author)

arXiv Construction and beam-tests of silicon-tungsten prototype modules for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

INSPIRE-00664095

2018-02-26

As part of its HL-LHC upgrade program, CMS is developing a High Granularity Calorimeter (HGCAL) to replace the existing endcap calorimeters. The HGCAL will be realised as a sampling calorimeter, including an electromagnetic compartment comprising 28 layers of silicon pad detectors with pad areas of 0.5–1.0 cm2 interspersed with absorbers. Prototype modules, based on 6-inch hexagonal silicon pad sensors with 128 channels, have been constructed and include many of the features required for this challenging detector. In 2016, beam tests of sampling configurations made from these modules have been conducted both at FNAL and at CERN using the Skiroc2 front-end ASIC (designed by the CALICE collaboration for ILC). In 2017, the setup has been extended with CALICE's AHCAL prototype, a scinitillator based sampling calorimeter, and it was further tested in dedicated beam tests at CERN. There, the new Skiroc2-CMS front-end ASIC was used for the first time. We highlight final results from our studies in 2016, including ...

ATLAS Tile Calorimeter Readout Electronics Upgrade Program for the High Luminosity LHC

CERN Document Server

Cerqueira, A S

2013-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the most central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. The ATLAS upgrade program is divided in three phases: The Phase~0 occurs during 2013-2014, Phase~1 during 2018-1019 and finally Phase~2, which is foreseen for 2022-2023, whereafter the peak luminosity will reach 5-7 x 10$^{34}$ cm$^2$s$^{-1}$ (HL-LHC). The main TileCal upgrade is focused on the Phase~2 period. The upgrade aims at replacing the majority of the on- and off-detector electronics so that all calorimeter signals are directly digitized and sent to the off-detector electronics in the counting room. All new electronics must be able to cope with the increased radiation levels. An ambitious upgrade development program is pursued to study different electronics options. Three options are presently being investigated for the front-end electronic upgrade. The first option is an improved version of the present system built using comm...

Design and performance of a vacuum-bottle solid-state calorimeter

International Nuclear Information System (INIS)

Bracken, D.S.; Biddle, R.; Cech, R.

1997-01-01

EG and G Mound Applied Technologies calorimetry personnel have developed a small, thermos-bottle solid-state calorimeter, which is now undergoing performance testing at Los Alamos National Laboratory. The thermos-bottle solid-state calorimeter is an evaluation prototype for characterizing the heat output of small heat standards and other homogeneous heat sources. The current maximum sample size is 3.5 in. long with a diameter of 0.8 in. The overall size of the thermos bottle and thermoelectric cooling device is 9.25 in. high by 3.75 in. diameter and less than 3 lb. Coupling this unit with compact electronics and a laptop computer makes this calorimeter easily hand carried by a single individual. This compactness was achieved by servo controlling the reference temperature below room temperature and replacing the water bath used in conventional calorimeter design with the thermos-bottle insulator. Other design features will also be discussed. The performance of the calorimeter will be presented

Readiness of the ATLAS Liquid Argon Calorimeter for LHC Collisions

CERN Document Server

Aad, G.; Abdallah, J.; Abdelalim, A.A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; Abramowicz, H.; Abreu, H.; Acharya, B.S.; Adams, D.L.; Addy, T.N.; Adelman, J.; Adorisio, C.; Adragna, P.; Adye, T.; Aefsky, S.; Aguilar-Saavedra, J.A.; Aharrouche, M.; Ahlen, S.P.; Ahles, F.; Ahmad, A.; Ahmed, H.; Ahsan, M.; Aielli, G.; Akdogan, T.; Akesson, T.P.A.; Akimoto, G.; Akimov, A.V.; Aktas, A.; Alam, M.S.; Alam, M.A.; Albert, J.; Albrand, S.; Aleksa, M.; Aleksandrov, I.N.; Alessandria, F.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Aliev, M.; Alimonti, G.; Alison, J.; Aliyev, M.; Allport, P.P.; Allwood-Spiers, S.E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alviggi, M.G.; Amako, K.; Amelung, C.; Ammosov, V.V.; Amorim, A.; Amorós, G.; Amram, N.; Anastopoulos, C.; Andeen, T.; Anders, C.F.; Anderson, K.J.; Andreazza, A.; Andrei, V.; Anduaga, X.S.; Angerami, A.; Anghinolfi, F.; Anjos, N.; Antonaki, A.; Antonelli, M.; Antonelli, S.; Antunovic, B.; Anulli, F.; Aoun, S.; Arabidze, G.; Aracena, I.; Arai, Y.; Arce, A.T.H.; Archambault, J.P.; Arfaoui, S.; Arguin, J-F; Argyropoulos, T.; Arik, E.; Arik, M.; Armbruster, A.J.; Arnaez, O.; Arnault, C.; Artamonov, A.; Arutinov, D.; Asai, M.; Asai, S.; Asfandiyarov, R.; Ask, S.; Asman, B.; Asner, D.; Asquith, L.; Assamagan, K.; Astbury, A.; Astvatsatourov, A.; Atoian, G.; Auerbach, B.; Auge, E.; Augsten, K.; Aurousseau, M.; Austin, N.; Avolio, G.; Avramidou, R.; Axen, D.; Ay, C.; Azuelos, G.; Azuma, Y.; Baak, M.A.; Baccaglioni, G.; Bacci, C.; Bach, A.; Bachacou, H.; Bachas, K.; Backes, M.; Badescu, E.; Bagnaia, P.; Bai, Y.; Bailey, D.C.; Bain, T.; Baines, J.T.; Baker, O.K.; Baker, M.D.; Baltasar Dos Santos Pedrosa, F; Banas, E.; Banerjee, P.; Banerjee, S.; Banfi, D.; Bangert, A.; Bansal, V.; Baranov, S.P.; Baranov, S.; Barashkou, A.; Barber, T.; Barberio, E.L.; Barberis, D.; Barbero, M.; Bardin, D.Y.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B.M.; Barnett, R.M.; Baron, S.; Baroncelli, A.; Barr, A.J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Barrillon, P.; Barros, N.; Bartoldus, R.; Bartsch, D.; Bastos, J.; Bates, R.L.; Bathe, S.; Batkova, L.; Batley, J.R.; Battaglia, A.; Battistin, M.; Bauer, F.; Bawa, H.S.; Bazalova, M.; Beare, B.; Beau, T.; Beauchemin, P.H.; Beccherle, R.; Becerici, N.; Bechtle, P.; Beck, G.A.; Beck, H.P.; Beckingham, M.; Becks, K.H.; Bedajanek, I.; Beddall, A.J.; Beddall, A.; Bednár, P.; Bednyakov, V.A.; Bee, C.; Begel, M.; Behar Harpaz, S; Behera, P.K.; Beimforde, M.; Belanger-Champagne, C.; Bell, P.J.; Bell, W.H.; Bella, G.; Bellagamba, L.; Bellina, F.; Bellomo, M.; Belloni, A.; Belotskiy, K.; Beltramello, O.; Ben Ami, S; Benary, O.; Benchekroun, D.; Bendel, M.; Benedict, B.H.; Benekos, N.; Benhammou, Y.; Benincasa, G.P.; Benjamin, D.P.; Benoit, M.; Bensinger, J.R.; Benslama, K.; Bentvelsen, S.; Beretta, M.; Berge, D.; Bergeaas Kuutmann, E; Berger, N.; Berghaus, F.; Berglund, E.; Beringer, J.; Bernardet, K.; Bernat, P.; Bernhard, R.; Bernius, C.; Berry, T.; Bertin, A.; Besson, N.; Bethke, S.; Bianchi, R.M.; Bianco, M.; Biebel, O.; Biesiada, J.; Biglietti, M.; Bilokon, H.; Bindi, M.; Binet, S.; Bingul, A.; Bini, C.; Biscarat, C.; Bitenc, U.; Black, K.M.; Blair, R.E.; Blanchard, J-B; Blanchot, G.; Blocker, C.; Blocki, J.; Blondel, A.; Blum, W.; Blumenschein, U.; Bobbink, G.J.; Bocci, A.; Boehler, M.; Boek, J.; Boelaert, N.; Böser, S.; Bogaerts, J.A.; Bogouch, A.; Bohm, C.; Bohm, J.; Boisvert, V.; Bold, T.; Boldea, V.; Boldyrev, A.; Bondarenko, V.G.; Bondioli, M.; Boonekamp, M.; Booth, J.R.A.; Bordoni, S.; Borer, C.; Borisov, A.; Borissov, G.; Borjanovic, I.; Borroni, S.; Bos, K.; Boscherini, D.; Bosman, M.; Bosteels, M.; Boterenbrood, H.; Bouchami, J.; Boudreau, J.; Bouhova-Thacker, E.V.; Boulahouache, C.; Bourdarios, C.; Boyd, J.; Boyko, I.R.; Bozovic-Jelisavcic, I.; Bracinik, J.; Braem, A.; Branchini, P.; Brandenburg, G.W.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J.E.; Braun, H.M.; Brelier, B.; Bremer, J.; 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Thompson, E.N.; Thompson, P.D.; Thompson, P.D.; Thompson, R.J.; Thompson, A.S.; Thomson, E.; Thun, R.P.; Tic, T.; Tikhomirov, V.O.; Tikhonov, Y.A.; Timmermans, C.J.W.P.; Tipton, P.; Tique-Aires-Viegas, F.J.; Tisserant, S.; Tobias, J.; Toczek, B.; Todorov, T.; Todorova-Nova, S.; Toggerson, B.; Tojo, J.; Tokár, S.; Tokushuku, K.; Tollefson, K.; Tomasek, L.; Tomasek, M.; Tomasz, F.; Tomoto, M.; Tompkins, D.; Tompkins, L.; Toms, K.; Tong, G.; Tonoyan, A.; Topfel, C.; Topilin, N.D.; Torrence, E.; Torró Pastor, E; Toth, J.; Touchard, F.; Tovey, D.R.; Tovey, S.N.; Trefzger, T.; Tremblet, L.; Tricoli, A.; Trigger, I.M.; Trincaz-Duvoid, S.; Trinh, T.N.; Tripiana, M.F.; Triplett, N.; Trivedi, A.; Trocmé, B.; Troncon, C.; Trzupek, A.; Tsarouchas, C.; Tseng, J.C-L.; Tsiafis, I.; Tsiakiris, M.; Tsiareshka, P.V.; Tsionou, D.; Tsipolitis, G.; Tsiskaridze, V.; Tskhadadze, E.G.; Tsukerman, I.I.; Tsulaia, V.; Tsung, J-W; Tsuno, S.; Tsybychev, D.; Turala, M.; Turecek, D.; Turk Cakir, I; Turlay, E.; Tuts, P.M.; Twomey, M.S.; Tylmad, M.; Tyndel, M.; Tzanakos, G.; Uchida, K.; Ueda, I.; Uhlenbrock, M.; Uhrmacher, M.; Ukegawa, F.; Unal, G.; Underwood, D.G.; Undrus, A.; Unel, G.; Unno, Y.; Urbaniec, D.; Urkovsky, E.; Urquijo, P.; Urrejola, P.; Usai, G.; Uslenghi, M.; Vacavant, L.; Vacek, V.; Vachon, B.; Vahsen, S.; Valenta, J.; Valente, P.; Valentinetti, S.; Valkar, S.; Valladolid Gallego, E; Vallecorsa, S.; Valls Ferrer, J A; Van Berg, R; van der Graaf, H; van der Kraaij, E; van der Poel, E; Van Der Ster, D; van Eldik, N; van Gemmeren, P; van Kesteren, Z; van Vulpen, I; Vandelli, W.; Vandoni, G.; Vaniachine, A.; Vankov, P.; Vannucci, F.; Varela Rodriguez, F; Vari, R.; Varnes, E.W.; Varouchas, D.; Vartapetian, A.; Varvell, K.E.; Vasilyeva, L.; Vassilakopoulos, V.I.; Vazeille, F.; Vegni, G.; Veillet, J.J.; Vellidis, C.; Veloso, F.; Veness, R.; Veneziano, S.; Ventura, A.; Ventura, D.; Venturi, M.; Venturi, N.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, J.C.; Vetterli, M.C.; Vichou, I.; Vickey, T.; Viehhauser, G.H.A.; Villa, M.; Villani, E.G.; Villaplana Perez, M; Villate, J.; Vilucchi, E.; Vincter, M.G.; Vinek, E.; Vinogradov, V.B.; Viret, S.; Virzi, J.; Vitale, A.; Vitells, O.V.; Vivarelli, I.; Vives Vaques, F; Vlachos, S.; Vlasak, M.; Vlasov, N.; Vogt, H.; Vokac, P.; Volpi, M.; Volpini, G.; von der Schmitt, H; von Loeben, J; von Radziewski, H; von Toerne, E; Vorobel, V.; Vorobiev, A.P.; Vorwerk, V.; Vos, M.; Voss, R.; Voss, T.T.; Vossebeld, J.H.; Vranjes, N.; Vranjes Milosavljevic, M; Vrba, V.; Vreeswijk, M.; Vu Anh, T; Vudragovic, D.; Vuillermet, R.; Vukotic, I.; Wagner, P.; Wahlen, H.; Walbersloh, J.; Walder, J.; Walker, R.; Walkowiak, W.; Wall, R.; Wang, C.; Wang, H.; Wang, J.; Wang, J.C.; Wang, S.M.; Ward, C.P.; Warsinsky, M.; Wastie, R.; Watkins, P.M.; Watson, A.T.; Watson, M.F.; Watts, G.; Watts, S.; Waugh, A.T.; Waugh, B.M.; Webel, M.; Weber, J.; Weber, M.D.; Weber, M.; Weber, M.S.; Weber, P.; Weidberg, A.R.; Weingarten, J.; Weiser, C.; Wellenstein, H.; Wells, P.S.; Wen, M.; Wenaus, T.; Wendler, S.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Werth, M.; Werthenbach, U.; Wessels, M.; Whalen, K.; Wheeler-Ellis, S.J.; Whitaker, S.P.; White, A.; White, M.J.; White, S.; Whiteson, D.; Whittington, D.; Wicek, F.; Wicke, D.; Wickens, F.J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik, L.A.M.; Wildauer, A.; Wildt, M.A.; Wilhelm, I.; Wilkens, H.G.; Williams, E.; Williams, H.H.; Willis, W.; Willocq, S.; Wilson, J.A.; Wilson, M.G.; Wilson, A.; Wingerter-Seez, I.; Winklmeier, F.; Wittgen, M.; Wolter, M.W.; Wolters, H.; Wosiek, B.K.; Wotschack, J.; Woudstra, M.J.; Wraight, K.; Wright, C.; Wright, D.; Wrona, B.; Wu, S.L.; Wu, X.; Wulf, E.; Xella, S.; Xie, S.; Xie, Y.; Xu, D.; Xu, N.; Yamada, M.; Yamamoto, A.; Yamamoto, S.; Yamamura, T.; Yamanaka, K.; Yamaoka, J.; Yamazaki, T.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, U.K.; Yang, Y.; Yang, Z.; Yao, W-M; Yao, Y.; Yasu, Y.; Ye, J.; Ye, S.; Yilmaz, M.; Yoosoofmiya, R.; Yorita, K.; Yoshida, R.; Young, C.; Youssef, S.P.; Yu, D.; Yu, J.; Yu, M.; Yu, X.; Yuan, J.; Yuan, L.; Yurkewicz, A.; Zaidan, R.; Zaitsev, A.M.; Zajacova, Z.; Zambrano, V.; Zanello, L.; Zarzhitsky, P.; Zaytsev, A.; Zeitnitz, C.; Zeller, M.; Zema, P.F.; Zemla, A.; Zendler, C.; Zenin, O.; Zenis, T.; Zenonos, Z.; Zenz, S.; Zerwas, D.; Zevi della Porta, G; Zhan, Z.; Zhang, H.; Zhang, J.; Zhang, Q.; Zhang, X.; Zhao, L.; Zhao, T.; Zhao, Z.; Zhemchugov, A.; Zheng, S.; Zhong, J.; Zhou, B.; Zhou, N.; Zhou, Y.; Zhu, C.G.; Zhu, H.; Zhu, Y.; Zhuang, X.; Zhuravlov, V.; Zilka, B.; Zimmermann, R.; Zimmermann, S.; Zimmermann, S.; Ziolkowski, M.; Zitoun, R.; Zivkovic, L.; Zmouchko, V.V.; Zobernig, G.; Zoccoli, A.; zur Nedden, M; Zutshi, V.

2010-01-01

The ATLAS liquid argon calorimeter has been operating continuously since August 2006. At this time, only part of the calorimeter was readout, but since the beginning of 2008, all calorimeter cells have been connected to the ATLAS readout system in preparation for LHC collisions. This paper gives an overview of the liquid argon calorimeter performance measured in situ with random triggers, calibration data, cosmic muons, and LHC beam splash events. Results on the detector operation, timing performance, electronics noise, and gain stability are presented. High energy deposits from radiative cosmic muons and beam splash events allow to check the intrinsic constant term of the energy resolution. The uniformity of the electromagnetic barrel calorimeter response along eta (averaged over phi) is measured at the percent level using minimum ionizing cosmic muons. Finally, studies of electromagnetic showers from radiative muons have been used to cross-check the Monte Carlo simulation. The performance results obtained u...

Overview of the Calorimeter Readout Upgrades

CERN Document Server

Straessner, Arno; The ATLAS collaboration

2018-01-01

The ATLAS and CMS calorimeter electronics will be upgraded for the HL-LHC data taking phase to cope with higher event pile-up and to allow improved trigger strategies. This presentations gives an overview of the ongoing developments for the CMS barrel calorimeters and the ATLAS LAr and Tile calorimeters.

Design and performance studies of a hadronic calorimeter for a FCC-hh experiment

Science.gov (United States)

Faltova, J.

2018-03-01

The hadron-hadron Future Circular Collider (FCC-hh) project studies the physics reach of a proton-proton machine with a centre-of-mass-energy of 100 TeV and five times greater peak luminosities than at the High-Luminosity LHC (HL-LHC). The high-energy regime of the FCC-hh opens new opportunities for the discovery of physics beyond the standard model. At 100 TeV a large fraction of the W, Z, H bosons and top quarks are produced with a significant boost. It implies an efficient reconstruction of very high energetic objects decaying hadronically. The reconstruction of those boosted objects sets the calorimeter performance requirements in terms of energy resolution, containment of highly energetic hadron showers, and high transverse granularity. We present the current baseline technologies for the calorimeter system in the barrel region of the FCC-hh reference detector: a liquid argon electromagnetic and a scintillator-steel hadronic calorimeters. The focus of this paper is on the hadronic calorimeter and the performance studies for hadrons. The reconstruction of single particles and the achieved energy resolution for the combined system of the electromagnetic and hadronic calorimeters are discussed.

Modelling of a holographic interferometry based calorimeter for radiation dosimetry

Science.gov (United States)

Beigzadeh, A. M.; Vaziri, M. R. Rashidian; Ziaie, F.

2017-08-01

In this research work, a model for predicting the behaviour of holographic interferometry based calorimeters for radiation dosimetry is introduced. Using this technique for radiation dosimetry via measuring the variations of refractive index due to energy deposition of radiation has several considerable advantages such as extreme sensitivity and ability of working without normally used temperature sensors that disturb the radiation field. We have shown that the results of our model are in good agreement with the experiments performed by other researchers under the same conditions. This model also reveals that these types of calorimeters have the additional and considerable merits of transforming the dose distribution to a set of discernible interference fringes.

Reconfigurable and ultra-sensitive in-line Mach-Zehnder interferometer based on the fusion of microfiber and microfluid

Energy Technology Data Exchange (ETDEWEB)

Gao, Shecheng [Key Laboratory of Optical Information Science and Technology, Ministry of Education, Institute of Modern Optics, Nankai University, Tianjin 300071 (China); Institute of Micro and Nano Optics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060 (China); Zhang, Weigang, E-mail: zhangwg@nankai.edu.cn, E-mail: haozhang@nankai.edu.cn; Zhang, Hao, E-mail: zhangwg@nankai.edu.cn, E-mail: haozhang@nankai.edu.cn [Key Laboratory of Optical Information Science and Technology, Ministry of Education, Institute of Modern Optics, Nankai University, Tianjin 300071 (China); Zhang, Chonglei [Institute of Micro and Nano Optics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060 (China)

2015-02-23

A reconfigurable Mach-Zenhnder interferometer (MZI) based on a microfluidic cavity (MFC) constructed by embedding a microfiber between two segments of single-mode fibers with pre-designed lateral offset has been proposed and experimentally demonstrated. The MFC serves as an interference arm with an eccentric annular cross section and allows convenient sample (gas or liquids) replacement procedure. The microfiber works as the other interference arm that provides the proposed device with ease of reconstruction and also enhances the force sensitivity. The re-configurability and the ultra-wide tuning sensitivity range are demonstrated by immersing the MZI constructed with a 484 μm-long-MFC and a microfiber 44 μm in diameter in different droplets. Ultrahigh sensitivities of 34.65 nm/°C (∼88 380 nm/RIU) and −493.7 nm/N (∼−590 pm/με) are experimentally achieved using a droplet with a refractive index of ∼1.44.

Reconfigurable and ultra-sensitive in-line Mach-Zehnder interferometer based on the fusion of microfiber and microfluid

International Nuclear Information System (INIS)

Gao, Shecheng; Zhang, Weigang; Zhang, Hao; Zhang, Chonglei

2015-01-01

A reconfigurable Mach-Zenhnder interferometer (MZI) based on a microfluidic cavity (MFC) constructed by embedding a microfiber between two segments of single-mode fibers with pre-designed lateral offset has been proposed and experimentally demonstrated. The MFC serves as an interference arm with an eccentric annular cross section and allows convenient sample (gas or liquids) replacement procedure. The microfiber works as the other interference arm that provides the proposed device with ease of reconstruction and also enhances the force sensitivity. The re-configurability and the ultra-wide tuning sensitivity range are demonstrated by immersing the MZI constructed with a 484 μm-long-MFC and a microfiber 44 μm in diameter in different droplets. Ultrahigh sensitivities of 34.65 nm/°C (∼88 380 nm/RIU) and −493.7 nm/N (∼−590 pm/με) are experimentally achieved using a droplet with a refractive index of ∼1.44

Microfluidic Devices for Blood Fractionation

Directory of Open Access Journals (Sweden)

Chwee Teck Lim

2011-07-01

Full Text Available Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate blood into its individual components has innumerable applications in both clinical diagnosis and biological research. Yet, processing blood is not trivial. In the past decade, a flurry of new microfluidic based technologies has emerged to address this compelling problem. Microfluidics is an attractive solution for this application leveraging its numerous advantages to process clinical blood samples. This paper reviews the various microfluidic approaches realized to successfully fractionate one or more blood components. Techniques to separate plasma from hematologic cellular components as well as isolating blood cells of interest including certain rare cells are discussed. Comparisons based on common separation metrics including efficiency (sensitivity, purity (selectivity, and throughput will be presented. Finally, we will provide insights into the challenges associated with blood-based separation systems towards realizing true point-of-care (POC devices and provide future perspectives.

Microfluidic bead-based multienzyme-nanoparticle amplification for detection of circulating tumor cells in the blood using quantum dots labels

Energy Technology Data Exchange (ETDEWEB)

Zhang, He, E-mail: mzhang_he@126.com; Fu, Xin; Hu, Jiayi; Zhu, Zhenjun

2013-05-24

Graphical abstract: A microfluidic beads-based nucleic acid sensor for sensitive detection of circulating tumor cells (CTCs) in the blood using multienzyme-nanoparticle amplification and quantum dots labels was developed. The chip-based CTCs analysis could detect reverse transcription-polymerase chain reaction (RT-PCR) products of tumor cell as low as 1 tumor cell (e.g. CEA expressing cell) in 1 mL blood sample. This microfluidic beads-based nucleic acid sensor is a promising platform for disease-related nucleic acid molecules at the lowest level at their earliest incidence. -- Highlights: •Combination of microfluidic bead-based platform and enzyme–probe–AuNPs is proposed. •The developed nucleic acid sensor could respond to 5 fM of tumor associated DNA. •Microfluidic platform and multienzyme-labeled AuNPs greatly enhanced sensitivity. •The developed nucleic acid sensor could respond to RT-PCR products of tumor cell as low as 1 tumor cell in 1 mL blood sample. •We report a sensitive nucleic acid sensor for detection of circulating tumor cells. -- Abstract: This study reports the development of a microfluidic bead-based nucleic acid sensor for sensitive detection of circulating tumor cells in blood samples using multienzyme-nanoparticle amplification and quantum dot labels. In this method, the microbeads functionalized with the capture probes and modified electron rich proteins were arrayed within a microfluidic channel as sensing elements, and the gold nanoparticles (AuNPs) functionalized with the horseradish peroxidases (HRP) and DNA probes were used as labels. Hence, two signal amplification approaches are integrated for enhancing the detection sensitivity of circulating tumor cells. First, the large surface area of Au nanoparticle carrier allows several binding events of HRP on each nanosphere. Second, enhanced mass transport capability inherent from microfluidics leads to higher capture efficiency of targets because continuous flow within micro

Development of a pencil-type single shield graphite quasi-adiabatic calorimeter and comparison of its performance with a double-shield graphite calorimeter for the measurement of nuclear heat deposition rate in a fusion environment

International Nuclear Information System (INIS)

Joneja, O.P.; Rosselet, M.; Ligou, J.; Gardel, P.

1995-01-01

Recently, heat deposition rate measurements were reported that used a quasi-adiabatic double-shield graphite calorimeter. It was found that for a better understanding of nuclear heating due to incident radiation, having a calorimeter that could be conveniently moved axially and radially inside large material blocks would be advisable. Here, a simpler design, based on three elements, i.e., core, jacket, and shield is conceived. The fabrication and testing details are presented, and the performance of the current calorimeter is compared with a double-shield calorimeter under similar conditions. Such a system is found to be extremely sensitive and can be employed successfully at the LOTUS facility for future nuclear heat deposition rate measurements in large blocks of materials. The current design paves the way for the convenient testing of a large amount of kerma factor data required for constructing future fusion machines. The same configuration with minor changes can be extended to most of the fusion materials of interest. The core of the new calorimeter measures 11 mm in diameter and height and has overall dimensions of 24 mm in diameter and 180 mm in height. The response of the calorimeter is measured by placing it in front of the Haefely neutron generator. 12 refs., 16 figs., 9 tabs

OLED Hybrid Integrated Polymer Microfluidic Biosensing for Point of Care Testing

Directory of Open Access Journals (Sweden)

Ashwin Acharya

2015-09-01

Full Text Available This paper reports a microfluidic platform with external hybrid integration of an organic light emitting diode (OLED as an excitation source. This device can be used as a simple and cost effective biosensing element. The device is capable of rapid in-situ detection of biological elements such as sensing of interaction of antigen with fluorescent tagged antibody conjugates. These portable microfluidic systems have great potential for use an OLED in a single chip with very high accuracy and sensitivity for various point-of-care (POC diagnosis and lab on a chip (LOC applications, as the miniaturization of the biosensor is essential for handling smaller sample volumes in order to achieve high throughput. The biosensing element was successfully tested to detect anti-sheep IgG conjugates tagged to Alexafluor using a fluorescence based immunoassay method.

Microcontact printing with aminosilanes: creating biomolecule micro- and nanoarrays for multiplexed microfluidic bioassays.

Science.gov (United States)

Sathish, Shivani; Ricoult, Sébastien G; Toda-Peters, Kazumi; Shen, Amy Q

2017-05-21

Microfluidic systems integrated with protein and DNA micro- and nanoarrays have been the most sought-after technologies to satisfy the growing demand for high-throughput disease diagnostics. As the sensitivity of these systems relies on the bio-functionalities of the patterned recognition biomolecules, the primary concern has been to develop simple technologies that enable biomolecule immobilization within microfluidic devices whilst preserving bio-functionalities. To address this concern, we introduce a two-step patterning approach to create micro- and nanoarrays of biomolecules within microfluidic devices. First, we introduce a simple aqueous based microcontact printing (μCP) method to pattern arrays of (3-aminopropyl)triethoxysilane (APTES) on glass substrates, with feature sizes ranging from a few hundred microns down to 200 nm (for the first time). Next, these substrates are integrated with microfluidic channels to then covalently couple DNA aptamers and antibodies with the micro- and nanopatterned APTES. As these biomolecules are covalently tethered to the device substrates, the resulting bonds enable them to withstand the high shear stresses originating from the flow in these devices. We further demonstrated the flexibility of this technique, by immobilizing multiple proteins onto these APTES-patterned substrates using liquid-dispensing robots to create multiple microarrays. Next, to validate the functionalities of these microfluidic biomolecule microarrays, we perform (i) aptamer-based sandwich immunoassays to detect human interleukin 6 (IL6); and (ii) antibody-based sandwich immunoassays to detect human c-reactive protein (hCRP) with the limit of detection at 5 nM, a level below the range required for clinical screening. Lastly, the shelf-life potential of these ready-to-use microfluidic microarray devices is validated by effectively functionalizing the patterns with biomolecules up to 3 months post-printing. In summary, with a single printing step, this

The manufacturing engineering of a hermetic cast fiber calorimeter

International Nuclear Information System (INIS)

Coan, T.; Higby, D.; Sulak, L.; Worstell, W.; Winn, D.; Ayer, F.; Elder, C.; Sullivan, D.

1990-01-01

The authors have made the first pass at designing and engineering a cast lead calorimeter with a rapidity coverage to η = 5.5. The design preserves detector hermeticity. Plastic scintillating fibers provide a fast, hadronically compensated, high-resolution device. A lead-eutectic, which melts below the softening point of the plastic, provides an easily manufactured high Z absorber. This calorimeter, designed with the TEXAS SSC detector as a baseline, is easily scaled in size and in segmentation without major design changes

Performance of ATLAS L1 Calorimeter Trigger with data

CERN Document Server

Bracinik, J; The ATLAS collaboration

2010-01-01

The ATLAS first-level calorimeter trigger is a hardware-based system designed to identify high-pT jets, electron/photon and tau candidates and to measure total and missing ET in the ATLAS calorimeters. After more than two years of commissioning in situ with calibration data and cosmic rays, the system has now been extensively used to select the most interesting proton-proton collision events. Final tuning of timing and energy calibration has been carried out in 2010 to improve the trigger response to physics objects. An analysis of the performance of the level-1 calorimeter trigger will be presented, along with the techniques used to achieve these results.

Monitoring light source for CMS lead tungstate crystal calorimeter at LHC

CERN Document Server

Zhang Li Yuan; Zhu Ren Yuan; Liu Dun Can

2000-01-01

Light monitoring will serve as an inter calibration for CMS lead tungstate crystals in situ at LHC, which is crucial for maintaining crystal calorimeter's sub percent constant term in the energy resolution. This paper presents the design of the CMS ECAL monitoring light source and high level distribution system. The correlations between variations of the light output and the transmittance for the CMS choice of Y doped PbWO//4 crystals were investigated, and were used to study monitoring linearity and sensitivity as a function of the wavelength. The monitoring wavelength was determined so that a good linearity as well as adequate sensitivity can be achieved. The performance of a custom manufactured tunable laser system is presented. Issues related to monitoring precision are discussed. 29 Refs.

Dye-sensitized solar cell module realized photovoltaic and photothermal highly efficient conversion via three-dimensional printing technology

Institute of Scientific and Technical Information of China (English)

Qi-Zhang Huang; Yan-Qing Zhu; Ji-Fu Shi; Lei-Lei Wang; Liu-Wen Zhong; Gang Xu

2017-01-01

Three-dimensional (3D) printing technology is employed to improve the photovoltaic and photothermal conversion efficiency of dye-sensitized solar cell (DSC) module.The 3D-printed concentrator is optically designed and improves the photovoltaic efficiency of the DSC module from 5.48％ to 7.03％.Additionally,with the 3D-printed microfluidic device serving as water cooling,the temperature of the DSC can be effectively controlled,which is beneficial for keeping a high photovoltaic conversion efficiency for DSC module.Moreover,the 3D-printed microfluidic device can realize photothermal conversion with an instantaneous photothermal efficiency of 42.1％.The integrated device realizes a total photovoltaic and photothermal conversion efficiency of 49％ at the optimal working condition.

Test and characterization of a prototype silicon–tungsten electromagnetic calorimeter

Energy Technology Data Exchange (ETDEWEB)

Muhuri, Sanjib, E-mail: sanjibmuhuri@vecc.gov.in [Variable Energy Cyclotron Centre, Kolkata 700064 (India); Mukhopadhyay, Sourav; Chandratre, Vinay B.; Sukhwani, Menka [Bhabha Atomic Research Centre, Electronics Division, Trombay, Mumbai 400085 (India); Jena, Satyajit [Indian Institute of Technology, Bombay, Mumbai 400076 (India); Khan, Shuaib Ahmad; Nayak, Tapan K.; Saini, Jogender; Singaraju, Rama Narayana [Variable Energy Cyclotron Centre, Kolkata 700064 (India)

2014-11-11

New generation high-energy physics experiments demand high precision tracking and accurate measurements of a large number of particles produced in the collisions of elementary particles and heavy-ions. Silicon–tungsten (Si–W) calorimeters provide the most viable technological option to meet the requirements of particle detection in high multiplicity environments. We report a novel Si–W calorimeter design, which is optimized for γ/π{sup 0} discrimination up to high momenta. In order to test the feasibility of the calorimeter, a prototype mini-tower was constructed using silicon pad detector arrays and tungsten layers. The performance of the mini-tower was tested using pion and electron beams at the CERN Proton Synchrotron (PS). The experimental results are compared with the results from a detailed GEANT-4 simulation. A linear relationship between the observed energy deposition and simulated response of the mini-tower has been obtained, in line with our expectations.

Cell manipulation in microfluidics

International Nuclear Information System (INIS)

Yun, Hoyoung; Kim, Kisoo; Lee, Won Gu

2013-01-01

Recent advances in the lab-on-a-chip field in association with nano/microfluidics have been made for new applications and functionalities to the fields of molecular biology, genetic analysis and proteomics, enabling the expansion of the cell biology field. Specifically, microfluidics has provided promising tools for enhancing cell biological research, since it has the ability to precisely control the cellular environment, to easily mimic heterogeneous cellular environment by multiplexing, and to analyze sub-cellular information by high-contents screening assays at the single-cell level. Various cell manipulation techniques in microfluidics have been developed in accordance with specific objectives and applications. In this review, we examine the latest achievements of cell manipulation techniques in microfluidics by categorizing externally applied forces for manipulation: (i) optical, (ii) magnetic, (iii) electrical, (iv) mechanical and (v) other manipulations. We furthermore focus on history where the manipulation techniques originate and also discuss future perspectives with key examples where available. (topical review)

CaloCube: an innovative homogeneous calorimeter for the next-generation space experiments

Science.gov (United States)

Pacini, L.; Adriani, O.; Agnesi, A.; Albergo, S.; Auditore, L.; Basti, A.; Berti, E.; Bigongiari, G.; Bonechi, L.; Bonechi, S.; Bongi, M.; Bonvicini, V.; Bottai, S.; Brogi, P.; Cappello, G.; Carotenuto, G.; Castellini, G.; Cattaneo, P. W.; Chiari, M.; Daddi, N.; DAlessandro, R.; Detti, S.; Fasoli, M.; Finetti, N.; Lenzi, P.; Maestro, P.; Marrocchesi, P. S.; Miritello, M.; Mori, N.; Orzan, G.; Olmi, M.; Papini, P.; Pellegriti, M. G.; Pirzio, F.; Rappoldi, A.; Ricciarini, S.; Spillantini, P.; Starodubtsev, O.; Stolzi, F.; Suh, J. E.; Sulaj, A.; Tiberio, A.; Tricomi, A.; Trifirò, A.; Trimarchi, M.; Vannuccini, E.; Vedda, A.; Zampa, G.; Zampa, N.

2017-11-01

The direct measurement of the cosmic-ray spectrum, up to the knee region, is one of the instrumental challenges for next generation space experiments. The main issue for these measurements is a steeply falling spectrum with increasing energy, so the physics performance of the space calorimeters are primarily determined by their geometrical acceptance and energy resolution. CaloCube is a three-year R&D project, approved and financed by INFN in 2014, aiming to optimize the design of a space-born calorimeter. The peculiarity of the design of CaloCube is its capability of detecting particles coming from any direction, and not only those on its upper surface. To ensure that the quality of the measurement does not depend on the arrival direction of the particles, the calorimeter will be designed as homogeneous and isotropic as possible. In addition, to achieve a high discrimination power for hadrons and nuclei with respect to electrons, the sensitive elements of the calorimeter need to have a fine 3-D sampling capability. In order to optimize the detector performances with respect to the total mass of the apparatus, which is the most important constraint for a space launch, a comparative study of different scintillating materials has been performed using detailed Monte Carlo simulation based on the FLUKA package. In parallel to simulation studies, a prototype consisting in 14 layers of 3 x 3 CsI(Tl) crystals per layer has been assembled and tested with particle beams. An overview of the obtained results during the first two years of the project will be presented and the future of the detector will be discussed too.

Radiation hardness and precision timing study of silicon detectors for the CMS High Granularity Calorimeter (HGC)

Energy Technology Data Exchange (ETDEWEB)

Currás, Esteban, E-mail: ecurrasr@cern.ch [CERN, Organisation europnne pour la recherche nucleaire, CH-1211 Genéve 23 (Switzerland); Instituto de Física de Cantabria (CSIC-UC), Avda. los Castros s/n, E-39005 Santander (Spain); Fernández, Marcos [Instituto de Física de Cantabria (CSIC-UC), Avda. los Castros s/n, E-39005 Santander (Spain); Gallrapp, Christian [CERN, Organisation europnne pour la recherche nucleaire, CH-1211 Genéve 23 (Switzerland); Gray, Lindsey [Fermilab, Wilson Street and Kirk Road, Batavia, IL 60510-5011, Illinois (United States); Mannelli, Marcello [CERN, Organisation europnne pour la recherche nucleaire, CH-1211 Genéve 23 (Switzerland); Meridiani, Paolo [Istituto Nazionale Di Fisica Nucleare – Sezione di Roma, Piazzale Aldo Moro, 2, 00185 Roma (Italy); Moll, Michael [CERN, Organisation europnne pour la recherche nucleaire, CH-1211 Genéve 23 (Switzerland); Nourbakhsh, Shervin [University of Minnesota, Minneapolis, MN 55455 (United States); Scharf, Christian [Hamburg University, Notkestraße 85, 22607 Hamburg (Germany); Silva, Pedro [CERN, Organisation europnne pour la recherche nucleaire, CH-1211 Genéve 23 (Switzerland); Steinbrueck, Georg [Hamburg University, Notkestraße 85, 22607 Hamburg (Germany); Fatis, Tommaso Tabarelli de [Istituto Nazionale di Fisica Nucleare – Sezione di Milano-Bicocca Piazza della Scienza 3, 20126 Milano (Italy); Vila, Iván [Instituto de Física de Cantabria (CSIC-UC), Avda. los Castros s/n, E-39005 Santander (Spain)

2017-02-11

The high luminosity upgraded LHC or Phase-II is expected to increase the instantaneous luminosity by a factor of 10 beyond the LHC's design value, expecting to deliver 250 fb{sup −1} per year for a further 10 years of operation. Under these conditions the performance degradation due to integrated radiation dose will need to be addressed. The CMS collaboration is planning to upgrade the forward calorimeters. The replacement is called the High Granularity Calorimeter (HGC) and it will be realized as a sampling calorimeter with layers of silicon detectors interleaved. The sensors will be realized as pad detectors with sizes of less that ∼1.0 cm{sup 2} and an active thickness between 100 and 300 μm depending on the position, respectively, the expected radiation levels. For an integrated luminosity of 3000 fb{sup −1}, the electromagnetic calorimetry will sustain integrated doses of 1.5 MGy (150 Mrads) and neutron fluences up to 10{sup 16} neq/cm{sup 2}. A radiation tolerance study after neutron irradiation of 300, 200, and 100 μm n-on-p and p-on-n silicon pads irradiated to fluences up to 1.6×10{sup 16} neq/cm{sup 2} is presented. The properties of these diodes studied before and after irradiation were leakage current, capacitance, charge collection efficiency, annealing effects and timing capability. The results of these measurements validate these sensors as candidates for the HGC system.

Detailed GEANT description of the SDC central calorimeters

International Nuclear Information System (INIS)

Glagolev, V.V.; Li, W.

1994-01-01

This article represents the very detailed simulation model of the SDC central calorimeters and some results which were obtained using that model. The central calorimeters structure was coded on the GEANT 3.15 base in the frame of the SDCSIM environment. The SDCSIM is the general shell for simulation of the SDC set-up. The calorimeters geometry has been coded according to the FNAL and ANL engineering drawings and engineering data file. SDC central calorimeters detailed description is extremely useful for different simulation tasks, for fast simulation program parameters tuning, for different geometry especially studying (local response nonuniformity from bulkheads in the e.m. calorimeter and from coil supports and many others) and for the interpretation of the experimental data from the calorimeters. This simulation model is very useful for tasks of the test beam modules calorimeter calibration and for calorimeter in situ calibration. 3 refs., 8 figs

"Finger" structure of tiles in CMS Endcap Hadron Calorimeters

CERN Document Server

Afanasiev, Sergey; Danilov, Mikhail; Emeliantchik, Igor; Ershov, Yuri; Golutvin, Igor; Grinyov, B.V; Ibragimova, Elvira; Levchuk, Leonid; Litomin, Aliaksandr; Makankin, Alexander; Malakhov, Alexander; Moisenz, Petr; Nuritdinov, I; Popov, V.F; Rusinov, Vladimir; Shumeiko, Nikolai; Smirnov, Vitaly; Sorokin, Pavlo; Tarkovskiy, Evgueni; Tashmetov, A; Vasiliev, S.E; Yuldashev, Bekhzod; Zamyatin, Nikolay; Zhmurin, Petro

2015-01-01

Two CMS Endcap hadron calorimeters (HE) have been in operation for several years and contributed substantially to the success of the CMS Physics Program. The HE calorimeter suffered more from the radiation than it had been anticipated because of rapid degradation of scintillator segments (tiles) which have a high radiation flux of secondary particles. Some investigations of scintillators have shown that the degradation of plastic scintillator increases significantly at low dose rates. A proposal to upgrade up-grade the HE calorimeter has been prepared to provide a solution for survivability of the future LHC at higher luminosity and higher energy. A finger-strip plastic scintillator option has many advantages and is a lower cost alternative to keep the excellent HE performance at high luminosity. Measurements have been performed and this method has proved to be a good upgrade strategy.

Noise dependency with pile-up in the ATLAS Tile Calorimeter

CERN Document Server

Araque Espinosa, Juan Pedro; The ATLAS collaboration

2015-01-01

The Tile Calorimeter, TileCal, is the central hadronic calorimeter of the ATLAS experiment, positioned between the electromagnetic calorimeter and the muon chambers. It comprises alternating layers of steel (as absorber material) and plastic (as active material), known as tiles. Between 2009 and 2012, the LHC has performed better than expected producing proton-proton collisions at a very high rate. These conditions are really challenging when dealing with the energy measurements in the calorimeter since not only the energy from an interesting event will be measured but a component coming from other collisions which are difficult to distinguish from the interesting one will also be present. This component is referred to as pile-up noise. Studies carried out to better understand how pile-up affects noise under different circumstances are described.

Tritium calorimeter setup and operation

CERN Document Server

Rodgers, D E

2002-01-01

The LBNL tritium calorimeter is a stable instrument capable of measuring tritium with a sensitivity of 25 Ci. Measurement times range from 8-hr to 7-days depending on the thermal conductivity and mass of the material being measured. The instrument allows accurate tritium measurements without requiring that the sample be opened and subsampled, thus reducing personnel exposure and radioactive waste generation. The sensitivity limit is primarily due to response shifts caused by temperature fluctuation in the water bath. The fluctuations are most likely a combination of insufficient insulation from ambient air and precision limitations in the temperature controller. The sensitivity could probably be reduced to below 5 Ci if the following improvements were made: (1) Extend the external insulation to cover the entire bath and increase the top insulation. (2) Improve the seal between the air space above the bath and the outside air to reduce evaporation. This will limit the response drift as the water level drops. (...

Proton tracking in a high-granularity Digital Tracking Calorimeter for proton CT purposes

Science.gov (United States)

Pettersen, H. E. S.; Alme, J.; Biegun, A.; van den Brink, A.; Chaar, M.; Fehlker, D.; Meric, I.; Odland, O. H.; Peitzmann, T.; Rocco, E.; Ullaland, K.; Wang, H.; Yang, S.; Zhang, C.; Röhrich, D.

2017-07-01

Radiation therapy with protons as of today utilizes information from x-ray CT in order to estimate the proton stopping power of the traversed tissue in a patient. The conversion from x-ray attenuation to proton stopping power in tissue introduces range uncertainties of the order of 2-3% of the range, uncertainties that are contributing to an increase of the necessary planning margins added to the target volume in a patient. Imaging methods and modalities, such as Dual Energy CT and proton CT, have come into consideration in the pursuit of obtaining an as good as possible estimate of the proton stopping power. In this study, a Digital Tracking Calorimeter is benchmarked for proof-of-concept for proton CT purposes. The Digital Tracking Calorimeter was originally designed for the reconstruction of high-energy electromagnetic showers for the ALICE-FoCal project. The presented prototype forms the basis for a proton CT system using a single technology for tracking and calorimetry. This advantage simplifies the setup and reduces the cost of a proton CT system assembly, and it is a unique feature of the Digital Tracking Calorimeter concept. Data from the AGORFIRM beamline at KVI-CART in Groningen in the Netherlands and Monte Carlo simulation results are used to in order to develop a tracking algorithm for the estimation of the residual ranges of a high number of concurrent proton tracks. High energy protons traversing the detector leave a track through the sensor layers. These tracks are spread out through charge diffusion processes. A charge diffusion model is applied for acquisition of estimates of the deposited energy of the protons in each sensor layer by using the size of the charge diffused area. A model fit of the Bragg Curve is applied to each reconstructed track and through this, estimating the residual range of each proton. The range of the individual protons can at present be estimated with a resolution of 4%. The readout system for this prototype is able to

Proton tracking in a high-granularity Digital Tracking Calorimeter for proton CT purposes

Energy Technology Data Exchange (ETDEWEB)

Pettersen, H.E.S., E-mail: helge.pettersen@helse-bergen.no [Department of Oncology and Medical Physics, Haukeland University Hospital, Postbox 1400, 5021 Bergen (Norway); Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway); Alme, J. [Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway); Biegun, A. [Kernfysisch Versneller Instituut, University of Groningen, NL-9747 AA Groningen (Netherlands); Brink, A. van den [Nikhef, Utrecht University, Postbox 41882, 1009 DB Amsterdam (Netherlands); Chaar, M.; Fehlker, D. [Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway); Meric, I. [Department of Electrical Engineering, Bergen University College, Postbox 7030, 5020 Bergen (Norway); Odland, O.H. [Department of Oncology and Medical Physics, Haukeland University Hospital, Postbox 1400, 5021 Bergen (Norway); Peitzmann, T.; Rocco, E. [Nikhef, Utrecht University, Postbox 41882, 1009 DB Amsterdam (Netherlands); Ullaland, K. [Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway); Wang, H. [Nikhef, Utrecht University, Postbox 41882, 1009 DB Amsterdam (Netherlands); Yang, S. [Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway); Zhang, C. [Nikhef, Utrecht University, Postbox 41882, 1009 DB Amsterdam (Netherlands); Röhrich, D. [Department of Physics and Technology, University of Bergen, Postbox 7803, 5020 Bergen (Norway)

2017-07-11

Radiation therapy with protons as of today utilizes information from x-ray CT in order to estimate the proton stopping power of the traversed tissue in a patient. The conversion from x-ray attenuation to proton stopping power in tissue introduces range uncertainties of the order of 2–3% of the range, uncertainties that are contributing to an increase of the necessary planning margins added to the target volume in a patient. Imaging methods and modalities, such as Dual Energy CT and proton CT, have come into consideration in the pursuit of obtaining an as good as possible estimate of the proton stopping power. In this study, a Digital Tracking Calorimeter is benchmarked for proof-of-concept for proton CT purposes. The Digital Tracking Calorimeter was originally designed for the reconstruction of high-energy electromagnetic showers for the ALICE-FoCal project. The presented prototype forms the basis for a proton CT system using a single technology for tracking and calorimetry. This advantage simplifies the setup and reduces the cost of a proton CT system assembly, and it is a unique feature of the Digital Tracking Calorimeter concept. Data from the AGORFIRM beamline at KVI-CART in Groningen in the Netherlands and Monte Carlo simulation results are used to in order to develop a tracking algorithm for the estimation of the residual ranges of a high number of concurrent proton tracks. High energy protons traversing the detector leave a track through the sensor layers. These tracks are spread out through charge diffusion processes. A charge diffusion model is applied for acquisition of estimates of the deposited energy of the protons in each sensor layer by using the size of the charge diffused area. A model fit of the Bragg Curve is applied to each reconstructed track and through this, estimating the residual range of each proton. The range of the individual protons can at present be estimated with a resolution of 4%. The readout system for this prototype is able to

The CMS Electromagnetic Calorimeter: Construction, Commissioning and Calibration

CERN Document Server

ORIMOTO,Toyoko J.

2009-01-01

The Compact Muon Solenoid (CMS) detector at the Large Hadron Colider (LHC) is ready for first collisions. The Electromagnetic Calorimeter (ECAL) of CMS, a high resolution detector comprised of nearly 76000 lead tungstate crystals, will play a crucial role in the coming physics searches undertaken by CMS. The design and performance of the CMS ECAL with test beams, cosmic rays, and first single beam data will be presented. In addition, the status of the calorimeter and plans for calibration with first collisions will be discussed. European Physical Society Europhysics Conference on High Energy Physics July 16-22, 2009 Krakow, Poland ∗Speaker.

Performance of a parallel plate volume calorimeter prototype

International Nuclear Information System (INIS)

Arefiev, A.; Bencze, Gy.L.; Bizzeti, A.; Choumilov, E.; Civinini, C; D'Alessandro, R.; Ferrando, A.; Fouz, M.C.; Iglesias, A.; Ivochkin, V.; Josa, M.I.; Malinin, A.; Meschini, M.; Misyura, S.; Pojidaev, V.; Salicio, J.M.; Sikler, F.

1995-01-01

An iron/gas parallel plate volume calorimeter prototype, working in the avalanche mode, has been tested using electrons of 20 to 150 GeV/c momentum with high voltages varying from 5400 to 5600 V (electric fields ranging from 36 to 37 KV/cm), and a gas mixture of CF4/CO, (80/20%). The collected charge was measured as a function of the high voltage and of the electron energy. The energy resolution was also measured. Comparisons are made with Monte-Carlo predictions. Agreement between data and simulation allows the calculation of the expected performance of a full size calorimeter. (Author)

Performance of a parallel plate volume calorimeter prototype

International Nuclear Information System (INIS)

Arefiev, A.; Bencze, G.L.; Bizzeti, A.

1995-09-01

An iron/gas parallel plate volume calorimeter prototype, working in the avalanche mode, has been tested using electrons of 20 to 150 GeV/c momentum with high voltages varying from 5400 to 5600 V (electric fields ranging from 36 to 37 KV/cm), and a gas mixture of CF 4 /CO 2 (80/20%). The collected charge was measured as a function of the high voltage and of the electron energy. The energy resolution was also measured. Comparisons are made with Monte-Carlo predictions. Agreement between data and simulation allows the calculation of the expected performance of a full size calorimeter

A High-Granularity Timing Detector for the Phase-II upgrade of the ATLAS Calorimeter system

CERN Document Server

Lenzi, Bruno; The ATLAS collaboration

2017-01-01

The expected increase of the particle flux at the high luminosity phase of the LHC (HL-LHC) with instantaneous luminosities up to L = 7.5 x 10^34 cm−2s−1 will have a severe impact on pile-up. The pile-up is expected to increase on average to 200 interactions per bunch crossing. The reconstruction and trigger performance for electrons, photons as well as jets and transverse missing energy will be severely degraded in the end-cap and forward region, where the liquid Argon based electromagnetic calorimeter has coarser granularity compared to the central region. A High Granularity Timing Detector (HGTD) is proposed in front of the liquid Argon end-cap calorimeters for pile-up mitigation at Level-0 (L0) trigger level and in the offline reconstruction. This device should cover the pseudo-rapidity range of 2.4 to about 4.2. Four layers of Silicon sensors, possibly interleaved with Tungsten, are foreseen to provide precision timing information for charged and neutral particles with a time resolution of the order ...

A High-Granularity Timing Detector for the Phase-II upgrade of the ATLAS Calorimeter system

CERN Document Server

Masetti, Lucia; The ATLAS collaboration

2017-01-01

The expected increase of the particle flux at the high luminosity phase of the LHC (HL-LHC) with instantaneous luminosities up to L=7.5 x 10^34 cm^-2 s^-1 will have a severe impact on pile-up. The pile-up is expected to increase on average to 200 interactions per bunch crossing. The reconstruction and trigger performance for electrons, photons as well as jets and transverse missing energy will be severely degraded in the end-cap and forward region, where the liquid Argon based electromagnetic calorimeter has coarser granularity compared to the central region. A High Granular Timing Detector (HGTD) is proposed in front of the liquid Argon end-cap calorimeters for pile-up mitigation at Level-0 (L0) trigger level and in offline reconstruction. This device should cover the pseudo-rapidity range of 2.4 to about 4.2. Four layers of Silicon sensors, possibly interleaved with Tungsten, are foreseen to provide precision timing information for charged and neutral particles with a time resolution of the order of 50 pico...

High-Granularity Timing Detector for the Phase-II up-grade of the ATLAS Calorimeter system

CERN Document Server

Gkougkousis, Evangelos Leonidas; The ATLAS collaboration

2017-01-01

The expected increase of the particle flux at the high luminosity phase of the LHC (HL-LHC) with instantaneous luminosities up to L ≃ 7.5×1034 cm−2s−1 will have a severe impact on pile-up. The pile-up is expected to increase on average to 200 interactions per bunch crossing. The reconstruction and trigger performance for electrons, photons as well as jets and transverse missing energy will be severely degraded in the end-cap and forward region, where the liquid Argon based electromagnetic calorimeter has coarser granularity compared to the central region. A High Granular Timing Detector (HGTD) is proposed in front of the liquid Argon end-cap calorimeters for pile-up mitigation at Level-0 (L0) trigger level and in offline reconstruction. This device should cover the pseudo-rapidity range of 2.4 to about 4.2. Four layers of Silicon sensors, possibly interleaved with Tungsten, are foreseen to provide precision timing information for charged and neutral particles with a time resolution of the order of 50 p...

ZnO-Based Microfluidic pH Sensor: A Versatile Approach for Quick Recognition of Circulating Tumor Cells in Blood.

Science.gov (United States)

Mani, Ganesh Kumar; Morohoshi, Madoka; Yasoda, Yutaka; Yokoyama, Sho; Kimura, Hiroshi; Tsuchiya, Kazuyoshi

2017-02-15

The present study is concerned about the development of highly sensitive and stable microfluidic pH sensor for possible identification of circulating tumor cells (CTCs) in blood. The precise pH measurements between silver-silver chloride (Ag/AgCl) reference electrode and zinc oxide (ZnO) working electrode have been investigated in the microfluidic device. Since there is a direct link between pH and cancer cells, the developed device is one of the valuable tools to examine circulating tumor cells (CTCs) in blood. The ZnO-based working electrode was deposited by radio frequency (rf) sputtering technique. The potential voltage difference between the working and reference electrodes (Ag/AgCl) is evaluated on the microfluidic device. The ideal Nernstian response of -43.71165 mV/pH was achieved along with high stability and quick response time. Finally, to evaluate the real time capability of the developed microfluidic device, in vitro testing was done with A549, A7r5, and MDCK cells.

Sensitive and predictable separation of microfluidic droplets by size using in-line passive filter.

Science.gov (United States)

Ding, Ruihua; Ung, W Lloyd; Heyman, John A; Weitz, David A

2017-01-01

Active manipulation of droplets is crucial in droplet microfluidics. However, droplet polydispersity decreases the accuracy of active manipulation. We develop a microfluidic "droplet filter" that accurately separates droplets by size. The droplet filter has a sharp size cutoff and is capable of distinguishing droplets differing in volume by 20%. A simple model explains the behavior of the droplets as they pass through the filter. We show application of the filter in improving dielectric sorting efficiency.

Construction of programmable interconnected 3D microfluidic networks

International Nuclear Information System (INIS)

Hunziker, Patrick R; Wolf, Marc P; Wang, Xueya; Zhang, Bei; Marsch, Stephan; Salieb-Beugelaar, Georgette B

2015-01-01

Microfluidic systems represent a key-enabling platform for novel diagnostic tools for use at the point-of-care in clinical contexts as well as for evolving single cell diagnostics. The design of 3D microfluidic systems is an active field of development, but construction of true interconnected 3D microfluidic networks is still a challenge, in particular when the goal is rapid prototyping, accurate design and flexibility. We report a novel approach for the construction of programmable 3D microfluidic systems consisting of modular 3D template casting of interconnected threads to allow user-programmable flow paths and examine its structural characteristics and its modular function. To overcome problems with thread template casting reported in the literature, low-surface-energy polymer threads were used, that allow solvent-free production. Connected circular channels with excellent roundness and low diameter variability were created. Variable channel termination allowed programming a flow path on-the-fly, thus rendering the resulting 3D microfluidic systems highly customizable even after production. Thus, construction of programmable/reprogrammable fully 3D microfluidic systems by template casting of a network of interconnecting threads is feasible, leads to high-quality and highly reproducible, complex 3D geometries. (paper)

R&D for a highly granular silicon tungsten electromagnetic calorimeter

CERN Document Server

Pöschl, R

2015-01-01

This article reports on first experience with the technological prototype of a highly- granular silicon-tungsten electromagnetic calorimeter as envisaged for the detectors at a future lepton collider. In the focus of the analysis is the performance of a highly integrated Application Specific Integrated Circuit designed to meet the requirements in terms of dynamic range, compactness and power consumption. The beam test results show that the circuit will allow a future detector with a signal over noise ratio of at least 10:1. To minimise the power dissipation the ASIC will be operated in a power pulsed mode. So far no conceptual problem was revealed but the studies show the way for further work. The prototype is read out by a DAQ system conceived to meet the needs of a trigger less system with a huge number of readout cells.

Performance of a scintillating fibres semiprojective electromagnetic calorimeter

International Nuclear Information System (INIS)

Bertino, M.; Bini, C.; De Zorzi, G.; Diambrini Palazzi, G.; Di Cosimo, G.; Di Domenico, A.; Garufi, F.; Gauzzi, P.; Zanello, D.

1995-01-01

A highly segmented scintillating fibres/lead electromagnetic calorimeter has been tested. Each calorimeter module has semiprojective geometry and is shaped as a wedge with an angle of (0.82) . The fibres are however parallel to the wedge axis and the two small lateral regions are not fibre-instrumented. This simple and cheap approach to a projective geometry allows to achieve still good energy and space resolution. Results with electrons in the range 10-100 GeV are presented. ((orig.))

A Compact Microwave Microfluidic Sensor Using a Re-Entrant Cavity

Directory of Open Access Journals (Sweden)

Hayder Hamzah

2018-03-01

Full Text Available A miniaturized 2.4 GHz re-entrant cavity has been designed, manufactured and tested as a sensor for microfluidic compositional analysis. It has been fully evaluated experimentally with water and common solvents, namely methanol, ethanol, and chloroform, with excellent agreement with the expected behaviour predicted by the Debye model. The sensor’s performance has also been assessed for analysis of segmented flow using water and oil. The samples’ interaction with the electric field in the gap region has been maximized by aligning the sample tube parallel to the electric field in this region, and the small width of the gap (typically 1 mm result in a highly localised complex permittivity measurement. The re-entrant cavity has simple mechanical geometry, small size, high quality factor, and due to the high concentration of electric field in the gap region, a very small mode volume. These factors combine to result in a highly sensitive, compact sensor for both pure liquids and liquid mixtures in capillary or microfluidic environments.

Manipulation of microfluidic droplets by electrorheological fluid

KAUST Repository

Zhang, Menying; Gong, Xiuqing; Wen, Weijia

2009-01-01

Microfluidics, especially droplet microfluidics, attracts more and more researchers from diverse fields, because it requires fewer materials and less time, produces less waste and has the potential of highly integrated and computer

Rapid Detection of Food Allergens by Microfluidics ELISA-Based Optical Sensor

Directory of Open Access Journals (Sweden)

Xuan Weng

2016-06-01

Full Text Available The risks associated with the presence of hidden allergens in food have increased the need for rapid, sensitive, and reliable methods for tracing food allergens in commodities. Conventional enzyme immunosorbent assay (ELISA has usually been performed in a centralized lab, requiring considerable time and sample/reagent consumption and expensive detection instruments. In this study, a microfluidic ELISA platform combined with a custom-designed optical sensor was developed for the quantitative analysis of the proteins wheat gluten and Ara h 1. The developed microfluidic ELISA biosensor reduced the total assay time from hours (up to 3.5 h to 15–20 min and decreased sample/reagent consumption to 5–10 μL, compared to a few hundred microliters in commercial ELISA kits, with superior sensitivity. The quantitative capability of the presented biosensor is a distinctive advantage over the commercially available rapid methods such as lateral flow devices (LFD and dipstick tests. The developed microfluidic biosensor demonstrates the potential for sensitive and less-expensive on-site determination for rapidly detecting food allergens in a complex sample system.

Large capacity water and air bath calorimeters

International Nuclear Information System (INIS)

James, S.J.; Kasperski, P.W.; Renz, D.P.; Wetzel, J.R.

1993-01-01

EG and G Mound Applied Technologies has developed an 11 in. x 17 in. sample size water bath and an 11 in. x 17 in. sample size air bath calorimeter which both function under servo control mode of operation. The water bath calorimeter has four air bath preconditioners to increase sample throughput and the air bath calorimeter has two air bath preconditioners. The large capacity calorimeters and preconditioners were unique to Mound design which brought about unique design challenges. Both large capacity systems calculate the optimum set temperature for each preconditioner which is available to the operator. Each system is controlled by a personal computer under DOS which allows the operator to download data to commercial software packages when the calorimeter is idle. Qualification testing yielded a one standard deviation of 0.6% for 0.2W to 3.0W Pu-238 heat standard range in the water bath calorimeter and a one standard deviation of 0.3% for the 6.0W to 20.0W Pu-238 heat standard range in the air bath calorimeter

High-throughput screening of filamentous fungi using nanoliter-range droplet-based microfluidics

Science.gov (United States)

Beneyton, Thomas; Wijaya, I. Putu Mahendra; Postros, Prexilia; Najah, Majdi; Leblond, Pascal; Couvent, Angélique; Mayot, Estelle; Griffiths, Andrew D.; Drevelle, Antoine

2016-06-01

Filamentous fungi are an extremely important source of industrial enzymes because of their capacity to secrete large quantities of proteins. Currently, functional screening of fungi is associated with low throughput and high costs, which severely limits the discovery of novel enzymatic activities and better production strains. Here, we describe a nanoliter-range droplet-based microfluidic system specially adapted for the high-throughput sceening (HTS) of large filamentous fungi libraries for secreted enzyme activities. The platform allowed (i) compartmentalization of single spores in ~10 nl droplets, (ii) germination and mycelium growth and (iii) high-throughput sorting of fungi based on enzymatic activity. A 104 clone UV-mutated library of Aspergillus niger was screened based on α-amylase activity in just 90 minutes. Active clones were enriched 196-fold after a single round of microfluidic HTS. The platform is a powerful tool for the development of new production strains with low cost, space and time footprint and should bring enormous benefit for improving the viability of biotechnological processes.

Combined microfluidization and ultrasonication: a synergistic protocol for high-efficient processing of SWCNT dispersions with high quality

Energy Technology Data Exchange (ETDEWEB)

Luo, Sida, E-mail: s.luo@buaa.edu.cn [Beihang University, School of Mechanical Engineering and Automation (China); Liu, Tao, E-mail: tliu@fsu.edu [Florida State University, High-Performance Materials Institute (United States); Wang, Yong; Li, Liuhe [Beihang University, School of Mechanical Engineering and Automation (China); Wang, Guantao; Luo, Yun [China University of Geosciences, Center of Safety Research, School of Engineering and Technology (China)

2016-08-15

High-efficient and large-scale production of high-quality CNT dispersions is necessary for meeting the future needs to develop various CNT-based electronic devices. Herein, we have designed novel processing protocols by combining conventional ultrasonication process with a new microfluidization technique to produce high-quality SWCNT dispersions with improved processing efficiency. To judge the quality of SWCNT dispersions, one critical factor is the degree of exfoliation, which could be quantified by both geometrical dimension of the exfoliated nanotubes and percentage of individual tubes in a given dispersion. In this paper, the synergistic effect of the combined protocols was systematically investigated through evaluating SWCNT dispersions with newly developed characterization techniques, namely preparative ultracentrifuge method (PUM) and simultaneous Raman scattering and photoluminescence spectroscopy (SRSPL). The results of both techniques draw similar conclusions that as compared with either of the processes operated separately, a low-pass microfluidization followed by a reasonable duration of ultrasonication could substantially improve the processing efficiency to produce high-quality SWCNT dispersions with averaged particle length and diameter as small as ~600 and ~2 nm, respectively.Graphical abstract.

Optimization of a microfluidic electrophoretic immunoassay using a Peltier cooler.

Science.gov (United States)

Mukhitov, Nikita; Yi, Lian; Schrell, Adrian M; Roper, Michael G

2014-11-07

Successful analysis of electrophoretic affinity assays depends strongly on the preservation of the affinity complex during separations. Elevated separation temperatures due to Joule heating promotes complex dissociation leading to a reduction in sensitivity. Affinity assays performed in glass microfluidic devices may be especially prone to this problem due to poor heat dissipation due to the low thermal conductivity of glass and the large amount of bulk material surrounding separation channels. To address this limitation, a method to cool a glass microfluidic chip for performing an affinity assay for insulin was achieved by a Peltier cooler localized over the separation channel. The Peltier cooler allowed for rapid stabilization of temperatures, with 21°C the lowest temperature that was possible to use without producing detrimental thermal gradients throughout the device. The introduction of cooling improved the preservation of the affinity complex, with even passive cooling of the separation channel improving the amount of complex observed by 2-fold. Additionally, the capability to thermostabilize the separation channel allowed for utilization of higher separation voltages than what was possible without temperature control. Kinetic CE analysis was utilized as a diagnostic of the affinity assay and indicated that optimal conditions were at the highest separation voltage, 6 kV, and the lowest separation temperature, 21°C, leading to 3.4% dissociation of the complex peak during the separation. These optimum conditions were used to generate a calibration curve and produced 1 nM limits of detection, representing a 10-fold improvement over non-thermostated conditions. This methodology of cooling glass microfluidic devices for performing robust and high sensitivity affinity assays on microfluidic systems should be amenable in a number of applications. Copyright © 2014 Elsevier B.V. All rights reserved.

The ATLAS Liquid Argon Calorimeters: integration, installation and commissioning

International Nuclear Information System (INIS)

Tikhonov, Yu.

2008-01-01

The ATLAS liquid argon calorimeter system consists of an electromagnetic barrel calorimeter and two end-caps with electromagnetic, hadronic and forward calorimeters positioned in three cryostats. Since May 2006 the LAr barrel calorimeter records regular calibration runs and takes cosmic muon data together with tile hadronic calorimeter in the ATLAS cavern. The cosmic runs with end-cap calorimeters started in April 2007. First results of these combined runs are presented

Noise dependence with pile-up in the ATLAS Tile calorimeter

CERN Document Server

Araque Espinosa, Juan Pedro; The ATLAS collaboration

2015-01-01

The Tile Calorimeter, TileCal, is the central hadronic calorimeter of the ATLAS experiment and comprises alternating layers of steel (as absorber material) and plastic (as active material), known as tiles. Between 2009 and 2012, the LHC has performed better than expected producing proton-proton collisions at a very high rate. Under these challenging conditions not only the energy from an interesting event will be measured but also a component coming from other collisions. This component is referred to as pile-up noise. Studies carried out to better understand how pile-up affects calorimeter noise under different circumstances are described.

ATLAS Tile Calorimeter Readout Electronics Upgrade Program for the High Luminosity LHC

CERN Document Server

Cerqueira, A S; The ATLAS collaboration

2013-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the most central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. The ATLAS upgrade program is divided in three phases: The Phase 0 occurs during 2013-2014 and prepares the LHC to reach peak luminosities of 1034 cm2s-1; Phase 1, foreseen for 2018-1019, prepares the LHC for peak luminosity up to 2-3 x 1034 cm2s-1, corresponding to 55 to 80 interactions per bunch-crossing with 25 ns bunch interval; and Phase 2 is foreseen for 2022-2023, whereafter the peak luminosity will reach 5-7 x 1034 cm2s-1 (HL-LHC). With luminosity leveling, the average luminosity will increase with a factor 10. The main TileCal upgrade is focused on the HL-LHC period. The upgrade aims at replacing the majority of the on- and off-detector electronics so that all calorimeter signals are directly digitized and sent to the off-detector electronics in the counting room. All new electronics must be able to cope with the increased rad...

Multiple and high-throughput droplet reactions via combination of microsampling technique and microfluidic chip

KAUST Repository

Wu, Jinbo

2012-11-20

Microdroplets offer unique compartments for accommodating a large number of chemical and biological reactions in tiny volume with precise control. A major concern in droplet-based microfluidics is the difficulty to address droplets individually and achieve high throughput at the same time. Here, we have combined an improved cartridge sampling technique with a microfluidic chip to perform droplet screenings and aggressive reaction with minimal (nanoliter-scale) reagent consumption. The droplet composition, distance, volume (nanoliter to subnanoliter scale), number, and sequence could be precisely and digitally programmed through the improved sampling technique, while sample evaporation and cross-contamination are effectively eliminated. Our combined device provides a simple model to utilize multiple droplets for various reactions with low reagent consumption and high throughput. © 2012 American Chemical Society.

Upgrading the ATLAS Tile Calorimeter electronics

CERN Document Server

Souza, J; The ATLAS collaboration

2014-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. Its main upgrade will occur for the High Luminosity LHC phase (phase 2) where the peak luminosity will increase 5-fold compared to the design luminosity (10exp34 cm−2s−1) but with maintained energy (i.e. 7+7 TeV). An additional increase of the average luminosity with a factor of 2 can be achieved by luminosity leveling. This upgrade will probably happen around 2023. The upgrade aims at replacing the majority of the on- and off-detector electronics so that all calorimeter signals are directly digitized and sent to the off-detector electronics in the counting room. To achieve the required reliability, redundancy has been introduced at different levels. The smallest independent on-detector electronics module has been reduced from 45 channels to 6, greatly reducing the consequences of a failure in the on-detector electronics. The size of t...

Upgrade of the ATLAS Tile Calorimeter

CERN Document Server

Reed, Robert; The ATLAS collaboration

2014-01-01

The Tile Calorimeter (TileCal) is the main hadronic calorimeter covering the central region of the ATLAS experiment at LHC. TileCal readout consists of about 10000 channels. The bulk of its upgrade will occur for the High Luminosity LHC operation (Phase 2 around 2023) where the peak luminosity will increase 5x compared to the design luminosity (10^{34} cm^{-2}s^{-1}) but with maintained energy (i.e. 7+7 TeV). The TileCal upgrade aims to replace the majority of the on- and off-detector electronics so that all calorimeter signals can be digitized and directly sent to the off-detector electronics in the counting room. This will reduce pile-up problems and allow more complex trigger algorithms. To achieve the required reliability, redundancy has been introduced at different levels. Three different options are presently being investigated for the front-end electronic upgrade. Extensive test beam studies will determine which option will be selected. 10 Gbps optical links are used to read out all digitized data to t...

Upgrade of the ATLAS Tile Calorimeter

CERN Document Server

Moreno, P; The ATLAS collaboration

2016-01-01

The Tile Calorimeter (TileCal) is the central hadronic calorimeter covering the central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. The bulk of its upgrade will occur for the High Luminosity LHC phase (Phase 2) where the peak luminosity will increase 5$\\times$ compared to the design luminosity ($10^{34} cm^{-2}s^{-1}$) but with maintained energy (i.e. 7+7 TeV). The TileCal upgrade aims at replacing the majority of the on- and off-detector electronics to the extent that all calorimeter signals will be digitized and sent to the off-detector electronics in the counting room. To achieve the required reliability, redundancy has been introduced at different levels. Three different options are presently being investigated for the front-end electronic upgrade. Extensive test beam studies will determine which option will be selected. 10 Gbps optical links are used to read out all digitized data to the counting room while 5 Gbps down-links are used for synchronization, c...

High Granularity Calorimeter for the CMS Endcap at HL-LHC

CERN Document Server

Rusack, Roger

2016-01-01

Calorimetry at the High Luminosity LHC (HL-LHC) faces two enormous challenges, particularly in the forward direction radiation tolerance and unprecedented in-time event pileup. To meet these challenges, the CMS experiment has decided to construct a High Granularity Calorimeter (HGCAL), featuring an unprecedented transverse and longitudinal segmentation in a collider detector, both for electromagnetic and hadronic compartments. This will enable the optimal utilization of the Particle Flow Algorithms, with which the fine structure of showers can be measured and used to enhance particle identification, energy resolution and pileup rejection. The majority of the HGCAL will be based on robust and cost-effective hexagonal silicon sensors with ~1cm^2 or 0.5cm^2 hexagonal cell size, with the final 5 interaction lengths of the hadronic compartment being based on highly segmented plastic scintillator with SiPM readout. Here, we present an overview of the HGCAL project, including the motivation, engineering design, rea...

Micro-optics for microfluidic analytical applications.

Science.gov (United States)

Yang, Hui; Gijs, Martin A M

2018-02-19

This critical review summarizes the developments in the integration of micro-optical elements with microfluidic platforms for facilitating detection and automation of bio-analytical applications. Micro-optical elements, made by a variety of microfabrication techniques, advantageously contribute to the performance of an analytical system, especially when the latter has microfluidic features. Indeed the easy integration of optical control and detection modules with microfluidic technology helps to bridge the gap between the macroscopic world and chip-based analysis, paving the way for automated and high-throughput applications. In our review, we start the discussion with an introduction of microfluidic systems and micro-optical components, as well as aspects of their integration. We continue with a detailed description of different microfluidic and micro-optics technologies and their applications, with an emphasis on the realization of optical waveguides and microlenses. The review continues with specific sections highlighting the advantages of integrated micro-optical components in microfluidic systems for tackling a variety of analytical problems, like cytometry, nucleic acid and protein detection, cell biology, and chemical analysis applications.

SU-E-E-15: Design of a Water Calorimeter for Dual Use in An Integrated MRI-Linac and Gamma-Knife

Energy Technology Data Exchange (ETDEWEB)

Entezari, N [Ryerson University, Toronto, Ontario (Canada); Renaud, J [McGill University, Montreal, Quebec (Canada); Ly, D [Waterloo University, Waterloo, Ontario (Canada); Sarfehnia, A [Sunnybrook Hospital, Toronto, ON (Canada)

2015-06-15

Purpose: To design a water calorimeter for dual use in an integrated MRI-linac and Gamma-Knife. In calorimetry, dose to water is measured based on the assumption that energy absorbed in a sensitive volume is completely converted to temperature rise {sub (}ΔΤ{sub )} according to the specific heat capacity of the medium c: D=c*ΔT*k, where k is heat transfer correction factor and compensates for heat gain or loss at point of measurement due to conductive effects. Methods: A commercial finite element method software package was used to model four different water calorimeter designs. The long term (48 h) thermal stability of each design was accurately modeled, and the optimization of the final design was based on evaluation of the standard deviation of k for ten consecutive irradiation runs (lower standard deviation translates to greater thermal stability). Several insulator materials of varying thicknesses were investigated, and a sensitivity study of thermal stability to variations in ambient temperature fluctuations was undertaken. Specifically, we evaluated the effect of possible variations in coolant temperature circulating around the calorimeter tank in several scenarios (constant, slowly increasing, or fluctuating). Results: Due to MRI-compatibility requirements, the calorimeter is to be built entirely out of plastic. Among all insulation materials tested, solid state aerogel-based insulation resulted in least heat loss and thermal stability. The final design is cylindrical on top (to be used upright in MRI-linac) and semi-spherical at bottom (for use in GammaKnife). The range of k was found to be 1.002 ± 0.013 (k = 1), comparable with a k of 1.002 ± 0.014 for typical water calorimeters used in high energy beams. A long term stability of 0.36 µK/hr was evaluated. Conclusion: Optimization of a water calorimeter design for dual use in MRI-linac and Gamma-Knife has been completed and the device is currently in production. Supported by NSERC RGPIN 435608.

SU-E-E-15: Design of a Water Calorimeter for Dual Use in An Integrated MRI-Linac and Gamma-Knife

International Nuclear Information System (INIS)

Entezari, N; Renaud, J; Ly, D; Sarfehnia, A

2015-01-01

Purpose: To design a water calorimeter for dual use in an integrated MRI-linac and Gamma-Knife. In calorimetry, dose to water is measured based on the assumption that energy absorbed in a sensitive volume is completely converted to temperature rise ( ΔΤ ) according to the specific heat capacity of the medium c: D=c*ΔT*k, where k is heat transfer correction factor and compensates for heat gain or loss at point of measurement due to conductive effects. Methods: A commercial finite element method software package was used to model four different water calorimeter designs. The long term (48 h) thermal stability of each design was accurately modeled, and the optimization of the final design was based on evaluation of the standard deviation of k for ten consecutive irradiation runs (lower standard deviation translates to greater thermal stability). Several insulator materials of varying thicknesses were investigated, and a sensitivity study of thermal stability to variations in ambient temperature fluctuations was undertaken. Specifically, we evaluated the effect of possible variations in coolant temperature circulating around the calorimeter tank in several scenarios (constant, slowly increasing, or fluctuating). Results: Due to MRI-compatibility requirements, the calorimeter is to be built entirely out of plastic. Among all insulation materials tested, solid state aerogel-based insulation resulted in least heat loss and thermal stability. The final design is cylindrical on top (to be used upright in MRI-linac) and semi-spherical at bottom (for use in GammaKnife). The range of k was found to be 1.002 ± 0.013 (k = 1), comparable with a k of 1.002 ± 0.014 for typical water calorimeters used in high energy beams. A long term stability of 0.36 µK/hr was evaluated. Conclusion: Optimization of a water calorimeter design for dual use in MRI-linac and Gamma-Knife has been completed and the device is currently in production. Supported by NSERC RGPIN 435608

Windowless microfluidic platform based on capillary burst valves for high intensity x-ray measurements

International Nuclear Information System (INIS)

Vig, Asger Laurberg; Enevoldsen, Nikolaj; Thilsted, Anil Haraksingh; Eriksen, Johan; Kristensen, Anders; Haldrup, Kristoffer; Feidenhans'l, Robert; Nielsen, Martin Meedom

2009-01-01

We propose and describe a microfluidic system for high intensity x-ray measurements. The required open access to a microfluidic channel is provided by an out-of-plane capillary burst valve (CBV). The functionality of the out-of-plane CBV is characterized with respect to the diameter of the windowless access hole, ranging from 10 to 130 μm. Maximum driving pressures from 22 to 280 mbar corresponding to refresh rates of the exposed sample from 300 Hz to 54 kHz is demonstrated. The microfluidic system is tested at beamline ID09b at the ESRF synchrotron radiation facility in Grenoble, and x-ray scattering measurements are shown to be feasible and to require only very limited amounts of sample, <1 ml/h of measurements without recapturing of sample. With small adjustments of the present chip design, scattering angles up to 30 deg. can be achieved without shadowing effects and integration on-chip mixing and spectroscopy appears straightforward.

CsI calorimeter of the CMD-3 detector

International Nuclear Information System (INIS)

Aulchenko, V.M.; Bondar, A.E.; Erofeev, A.L.; Kovalenko, O.A.; Kozyrev, A.N.; Kuzmin, A.S.; Logashenko, I.B.; Razuvaev, G.P.; Ruban, A.A.; Shebalin, V.E.; Shwartz, B.A.; Talyshev, A.A.; Titov, V.M.; Yudin, Yu.V.; Epifanov, D.A.

2015-01-01

The VEPP-2000 e + e − collider has been operated at Budker Institute of Nuclear Physics since 2010. The experiments are performed with two detectors CMD-3 and SND. The calorimetry at the CMD-3 detector is based on three subsystems, two coaxial barrel calorimeters—Liquid Xenon Calorimeter and crystal CsI calorimeter, and endcap calorimeter with BGO crystals. This paper describes the CsI calorimeter of the CMD-3 detector. The calorimeter design, its electronics and calibration procedures are discussed

The construction of the graphite calorimeter GR9 at LNE-LNHB (geometrical and technical consideration)

International Nuclear Information System (INIS)

Ostrowsky, A.; Daures, J.

2008-01-01

Calorimetry is the most direct dosimetric technique to reach absorbed dose. A calorimeter gives direct access to the energy imparted to matter by ionizing radiation per mass unit by measuring the heat quantity Q produced under irradiation in its sensitive element which is thermally insulated. Graphite was chosen as construction material because all the energy imparted to graphite by ionizing radiation is converted into heat. Thermistors are used for temperature measurements as well as for the electrical heating of the different bodies of the calorimeter. The construction of a calorimeter is the result of a compromise between dosimetric requirements and mechanical constraints. The difficulties encountered are examined and the solutions chosen are detailed. All technical data are gathered in this document. The aim is to provide a practical operative instruction and guidance document, which can help interested laboratories in designing such an instrument. The electrical and thermal tests have shown a good behaviour of the GR9 calorimeter

Upgrade of the ATLAS Hadronic Tile Calorimeter for the High Luminosity LHC

Science.gov (United States)

Tortajada, Ignacio Asensi

2018-01-01

The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade, in 2024, will accommodate the upgrade of the detector and data acquisition system for the HL-LHC. The Tile Calorimeter (TileCal) will undergo a major replacement of its on- and off-detector electronics. In the new architecture, all signals will be digitized and then transferred directly to the off-detector electronics, where the signals will be reconstructed, stored, and sent to the first level of trigger at the rate of 40 MHz. This will provide better precision of the calorimeter signals used by the trigger system and will allow the development of more complex trigger algorithms. Changes to the electronics will also contribute to the reliability and redundancy of the system. Three different front-end options are presently being investigated for the upgrade, two of them based on ASICs, and a final solution will be chosen after extensive laboratory and test beam studies that are in progress. A hybrid demonstrator module is being developed using the new electronics while conserving compatibility with the current system. The status of the developments will be presented, including results from the several tests with particle beams.

Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter

International Nuclear Information System (INIS)

Eigen, G.; Price, T.; Watson, N. K.; Marshall, J. S.; Thomson, M. A.; Ward, D. R.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Apostolakis, J.; Dotti, A.; Folger, G.; Ivantchenko, V.; Ribon, A.; Uzhinskiy, V.; Hostachy, J.-Y.; Morin, L.; Brianne, E.; Ebrahimi, A.; Gadow, K.

2016-01-01

The spatial development of hadronic showers in the CALICE scintillator-steel analogue hadron calorimeter is studied using test beam data collected at CERN and FNAL for single positive pions and protons with initial momenta in the range of 10–80 GeV/ c . Both longitudinal and radial development of hadron showers are parametrised with two-component functions. The parametrisation is fit to test beam data and simulations using the QGSP-BERT and FTFP-BERT physics lists from GEANT4 version 9.6. The parameters extracted from data and simulated samples are compared for the two types of hadrons. The response to pions and the ratio of the non-electromagnetic to the electromagnetic calorimeter response, h / e , are estimated using the extrapolation and decomposition of the longitudinal profiles.

Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter

CERN Document Server

Eigen, G.; Watson, N.K.; Marshall, J.S.; Thomson, M.A.; Ward, D.R.; Benchekroun, D.; Hoummada, A.; Khoulaki, Y.; Apostolakis, J.; Dotti, A.; Folger, G.; Ivantchenko, V.; Ribon, A.; Uzhinskiy, V.; Hostachy, J.Y.; Morin, L.; Brianne, E.; Ebrahimi, A.; Gadow, K.; Göttlicher, P.; Günter, C.; Hartbrich, O.; Hermberg, B.; Irles, A.; Krivan, F.; Krüger, K.; Kvasnicka, J.; Lu, S.; Lutz, B.; Morgunov, V.; Neubüser, C.; Provenza, A.; Reinecke, M.; Sefkow, F.; Schuwalow, S.; Tran, H.L.; Garutti, E.; Laurien, S.; Matysek, M.; Ramilli, M.; Schröder, S.; Briggl, K.; Eckert, P.; Munwes, Y.; Schultz-Coulon, H.-Ch.; Shen, W.; Stamen, R.; Bilki, B.; Norbeck, E.; Northacker, D.; Onel, Y.; Doren, B.van; Wilson, G.W.; Kawagoe, K.; Hirai, H.; Sudo, Y.; Suehara, T.; Sumida, H.; Takada, S.; Tomita, T.; Yoshioka, T.; Wing, M.; Bonnevaux, A.; Combaret, C.; Caponetto, L.; Grenier, G.; Han, R.; Ianigro, J.C.; Kieffer, R.; Laktineh, I.; Lumb, N.; Mathez, H.; Mirabito, L.; Steen, A.; Antequera, J.Berenguer; Alamillo, E.Calvo; Fouz, M.C.; Marin, J.; Puerta-Pelayo, J.; Verdugo, A.; Bobchenko, B.; Markin, O.; Novikov, E.; Rusinov, V.; Tarkovsky, E.; Kirikova, N.; Kozlov, V.; Smirnov, P.; Soloviev, Y.; Besson, D.; Buzhan, P.; Chadeeva, M.; Danilov, M.; Drutskoy, A.; Ilyin, A.; Mironov, D.; Mizuk, R.; Popova, E.; Gabriel, M.; Goecke, P.; Kiesling, C.; der Kolk, N.van; Simon, F.; Szalay, M.; Bilokin, S.; Bonis, J.; Cornebise, P.; Pöschl, R.; Richard, F.; Thiebault, A.; Zerwas, D.; Anduze, M.; Balagura, V.; Becheva, E.; Boudry, V.; Brient, J.C.; Cizel, J.B.; Clerc, C.; Cornat, R.; Frotin, M.; Gastaldi, F.; Magniette, F.; de Freitas, P.Mora; Musat, G.; Pavy, S.; Rubio-Roy, M.; Ruan, M.; Videau, H.; Callier, S.; Dulucq, F.; Martin-Chassard, G.; Raux, L.; Seguin-Moreau, N.; Taille, Ch.de la; Cvach, J.; Gallus, P.; Havranek, M.; Janata, M.; Lednicky, D.; Marcisovsky, M.; Polak, I.; Popule, J.; Tomasek, L.; Tomasek, M.; Sicho, P.; Smolik, J.; Vrba, V.; Zalesak, J.; Kotera, K.; Ono, H.; Takeshita, T.; Ieki, S.; Kamiya, Y.; Ootani, W.; Shibata, N.; Jeans, D.; Komamiya, S.; Nakanishi, H.

2016-06-23

The spatial development of hadronic showers in the CALICE scintillator-steel analogue hadron calorimeter is studied using test beam data collected at CERN and FNAL for single positive pions and protons with initial momenta in the range from 10 to 80 GeV/c. Both longitudinal and radial development of hadron showers are parametrised with two-component functions. The parametrisation is fit to test beam data and simulations using the QGSP_BERT and FTFP_BERT physics lists from Geant4 version 9.6. The parameters extracted from data and simulated samples are compared for the two types of hadrons. The response to pions and the ratio of the non-electromagnetic to the electromagnetic calorimeter response, h/e, are estimated using the extrapolation and decomposition of the longitudinal profiles.

Neutron calorimeter as a fusion diagnostic

International Nuclear Information System (INIS)

Proctor, A.E.; Nieschmidt, E.B.

1986-01-01

A calorimeter is described which is applicable as a fusion neutron diagnostic. The device has the following distinct advantages: low sensitivity to thermal neutrons, large dynamic range, small mass resulting in fair time resolution, small physical size, independent calibration, little shielding required, no heat loss to surroundings, and low cost. The heat generation is provided by neutron induced fissions in a foil of 235 U or 238 U. The effects, advantages, and disadvantages of these target materials are discussed. The expected time resolution and dynamic range are estimated for both target materials

Microfluidic acoustophoretic force based low-concentration oil separation and detection from the environment.

Science.gov (United States)

Wang, Han; Liu, Zhongzheng; Kim, Sungman; Koo, Chiwan; Cho, Younghak; Jang, Dong-Young; Kim, Yong-Joe; Han, Arum

2014-03-07

Detecting and quantifying extremely low concentrations of oil from the environment have broad applications in oil spill monitoring in ocean and coastal areas as well as in oil leakage monitoring on land. Currently available methods for low-concentration oil detection are bulky or costly with limited sensitivities. Thus they are difficult to be used as portable and field-deployable detectors in the case of oil spills or for monitoring the long-term effects of dispersed oil on marine and coastal ecosystems. Here, we present a low-concentration oil droplet trapping and detection microfluidic system based on the acoustophoresis phenomenon where oil droplets in water having a negative acoustic contrast factor move towards acoustic pressure anti-nodes. By trapping oil droplets from water samples flowing through a microfluidic channel, even very low concentrations of oil droplets can be concentrated to a detectable level for further analyses, which is a significant improvement over currently available oil detection systems. Oil droplets in water were successfully trapped and accumulated in a circular acoustophoretic trapping chamber of the microfluidic device and detected using a custom-built compact fluorescent detector based on the natural fluorescence of the trapped crude oil droplets. After the on-line detection, crude oil droplets released from the trapping chamber were successfully separated into a collection outlet by acoustophoretic force for further off-chip analyses. The developed microfluidic system provides a new way of trapping, detecting, and separating low-concentration crude oil from environmental water samples and holds promise as a low-cost field-deployable oil detector with extremely high sensitivity. The microfluidic system and operation principle are expected to be utilized in a wide range of applications where separating, concentrating, and detecting small particles having a negative acoustic contrast factor are required.

Construction and beam-tests of silicon-tungsten prototype modules for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Quast, Thorben

2017-01-01

As part of its HL-LHC upgrade program, CMS is developing a High Granularity Calorimeter (HGCAL) to replace the existing endcap calorimeters. The HGCAL will be realised as a sampling calorimeter, including an electromagnetic compartment comprising 28 layers of silicon pad detectors with pad areas of 0.5 - 1.0 cm$^2$ interspersed with absorbers.Prototype modules, based on 6-inch hexagonal silicon pad sensors with 128 channels, have been constructed and include many of the features required for this challenging detector. In 2016, beam tests of sampling configurations made from these modules have been conducted both at FNAL and at CERN using the Skiroc2 front-end chip (designed for the CALICE experiment for ILC). This year, the setup is extended with CALICE's AHCAL prototype and it is further tested in dedicated beam tests at CERN. There, the new Skiroc2-CMS front-end chip is used for the first time.We present final results from our studies in 2016, including noise performance, calibration with MIPs, energy and p...

Design studies and sensor tests for the beam calorimeter of the ILC detector

International Nuclear Information System (INIS)

Kuznetsova, E.

2007-03-01

The International Linear Collider (ILC) is being designed to explore particle physics at the TeV scale. The design of the Very Forward Region of the ILC detector is considered in the presented work. The Beam Calorimeter - one of two electromagnetic calorimeters situated there - is the subject of this thesis. The Beam Calorimeter has to provide a good hermeticity for high energy electrons, positrons and photons down to very low polar angles, serve for fast beam diagnostics and shield the inner part of the detector from backscattered beamstrahlung remnants and synchrotron radiation. As a possible technology for the Beam Calorimeter a diamond-tungsten sandwich calorimeter is considered. Detailed simulation studies are done in order to explore the suitability of the considered design for the Beam Calorimeter objectives. Detection efficiency, energy and angular resolution for electromagnetic showers are studied. At the simulation level the diamondtungsten design is shown to match the requirements on the Beam Calorimeter performance. Studies of polycrystalline chemical vapour deposition (pCVD) diamond as a sensor material for the Beam Calorimeter are done to explore the properties of the material. Results of the measurements performed with pCVD diamond samples produced by different manufacturers are presented. (orig.)

Design studies and sensor tests for the beam calorimeter of the ILC detector

Energy Technology Data Exchange (ETDEWEB)

Kuznetsova, E.

2007-03-15

The International Linear Collider (ILC) is being designed to explore particle physics at the TeV scale. The design of the Very Forward Region of the ILC detector is considered in the presented work. The Beam Calorimeter - one of two electromagnetic calorimeters situated there - is the subject of this thesis. The Beam Calorimeter has to provide a good hermeticity for high energy electrons, positrons and photons down to very low polar angles, serve for fast beam diagnostics and shield the inner part of the detector from backscattered beamstrahlung remnants and synchrotron radiation. As a possible technology for the Beam Calorimeter a diamond-tungsten sandwich calorimeter is considered. Detailed simulation studies are done in order to explore the suitability of the considered design for the Beam Calorimeter objectives. Detection efficiency, energy and angular resolution for electromagnetic showers are studied. At the simulation level the diamondtungsten design is shown to match the requirements on the Beam Calorimeter performance. Studies of polycrystalline chemical vapour deposition (pCVD) diamond as a sensor material for the Beam Calorimeter are done to explore the properties of the material. Results of the measurements performed with pCVD diamond samples produced by different manufacturers are presented. (orig.)

Development of an electron calorimeter to be used in high transverse momentum reaction studies

International Nuclear Information System (INIS)

Charpentier, Philippe.

1977-01-01

In order to select high transverse momentum particles, an electron calorimeter made of two super-units of 2x5 m 2 was developed. A new type of scintillator called Plexipop and having the following characteristics, was developed: the light produced equals only 20% of that produced by NE 110, it has a high attenuation length (about 3.80 m), and a short lifetime (5 nsec). Various calibration methods were defined for this apparatus. The resolution obtained was 5% at 10 GeV/c [fr

Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection.

Science.gov (United States)

Hosseini, Samira; Aeinehvand, Mohammad M; Uddin, Shah M; Benzina, Abderazak; Rothan, Hussin A; Yusof, Rohana; Koole, Leo H; Madou, Marc J; Djordjevic, Ivan; Ibrahim, Fatimah

2015-11-09

The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has secured an important position for their use in bioanalytical assays. Herein, we report a combination of microspheres and microfluidic disk in a unique hybrid platform for highly sensitive and selective detection of dengue virus. Surface engineered polymethacrylate microspheres with carefully designed functional groups facilitate biorecognition in a multitude manner. In order to maximize the utility of the microspheres' specific surface area in biomolecular interaction, the microfluidic disk was equipped with a micromixing system. The mixing mechanism (microballoon mixing) enhances the number of molecular encounters between spheres and target analyte by accessing the entire sample volume more effectively, which subsequently results in signal amplification. Significant reduction of incubation time along with considerable lower detection limits were the prime motivations for the integration of microspheres inside the microfluidic disk. Lengthy incubations of routine analytical assays were reduced from 2 hours to 5 minutes while developed system successfully detected a few units of dengue virus. Obtained results make this hybrid microsphere-microfluidic approach to dengue detection a promising avenue for early detection of this fatal illness.

A High-Throughput SU-8Microfluidic Magnetic Bead Separator

DEFF Research Database (Denmark)

Bu, Minqiang; Christensen, T. B.; Smistrup, Kristian

2007-01-01

We present a novel microfluidic magnetic bead separator based on SU-8 fabrication technique for high through-put applications. The experimental results show that magnetic beads can be captured at an efficiency of 91 % and 54 % at flow rates of 1 mL/min and 4 mL/min, respectively. Integration...... of soft magnetic elements in the chip leads to a slightly higher capturing efficiency and a more uniform distribution of captured beads over the separation chamber than the system without soft magnetic elements....

Feasibility of a Mound-designed transportable calorimeter

International Nuclear Information System (INIS)

Duff, M.F.; Fellers, C.L.

1979-01-01

The feasibility of operating a Mound twin resistance bridge calorimeter outside a temperature-controlled water bath was demonstrated. An existing calorimeter was retrofit with two additional jackets through which water was transferred from an external reservoir. Comparison of test results collected before and after the retrofit indicated that the calorimeter performance was not degraded by this modification. Similarly designed calorimeters have potential applications in laboratories where equipment space is limited for inspectors who are required to transport their assay instrumentation

Laser Calibration of the ATLAS Tile Calorimeter

CERN Document Server

Di Gregorio, Giulia; The ATLAS collaboration

2017-01-01

High performance stability of the ATLAS Tile Calorimeter is achieved with a set of calibration procedures. One step of the calibration procedure is based on measurements of the response stability to laser excitation of the PMTs that are used to readout the calorimeter cells. A facility to study in lab the PMT stability response is operating in the PISA-INFN laboratories since 2015. Goals of the tests in lab are to study the time evolution of the PMT response to reproduce and to understand the origin of the response drifts seen with the PMT mounted on the Tile calorimeter in its normal operating during LHC run I and run II. A new statistical approach was developed to measure drift of the absolute gain. This approach was applied to both the ATLAS laser calibration data and to data collected in the Pisa local laboratory. The preliminary results from these two studies are shown.

Laser calibration of the ATLAS Tile Calorimeter

CERN Document Server

Di Gregorio, Giulia; The ATLAS collaboration

2017-01-01

High performance stability of the ATLAS Tile calorimeter is achieved with a set of calibration procedures. One step of the calibrtion procedure is based on measurements of the response stability to laser excitation of the photomultipliers (PMTs) that are used to readout the calorimeter cells. A facility to study in lab the PMT stability response is operating in the PISA-INFN laboratories since 2015. Goals of the test in lab are to study the time evolution of the PMT response to reproduce and to understand the origin of the resonse drifts seen with the PMT mounted on the Tile calorimeter in its normal operation during LHC run I and run II. A new statistical approach was developed to measure the drift of the absolute gain. This approach was applied to both the ATLAS laser calibration data and to the data collected in the Pisa local laboratory. The preliminary results from these two studies are shown.

Upgrade of the ATLAS Tile Calorimeter Electronics

CERN Document Server

Carrio, F

2015-01-01

The Tile Calorimeter (TileCal) is the hadronic calorimeter covering the central region of the ATLAS experiment at LHC. The TileCal readout consists of about 10000 channels. The bulk of its upgrade will occur for the High Luminosity LHC phase (P hase - II ) where the pea k luminosity will increase 5 times compared to the design luminosity (10 34 cm −2 s −1 ) but with maintained energy (i.e. 7+7 TeV). An additional increase of the average luminosity with a factor of 2 can be achieved by luminosity levelling. This upgrade is expe cted to happen around 202 4 . The TileCal upgrade aims at replacing the majority of the on - and off - detector electronics to the extent that all calorimeter signals will be digitized and sent to the off - detector electronics in the counting room. To achieve th e required reliability, redundancy has been introduced at different levels. Three different options are presently being investiga...

The ATLAS Tile Calorimeter

CERN Document Server

Henriques Correia, Ana Maria

2015-01-01

TileCal is the Hadronic calorimeter covering the most central region of the ATLAS experiment at the LHC. It uses iron plates as absorber and plastic scintillating tiles as the active material. Scintillation light produced in the tiles is transmitted by wavelength shifting fibres to photomultiplier tubes (PMTs). The resulting electronic signals from the approximately 10000 PMTs are measured and digitised every 25 ns before being transferred to off-detector data-acquisition systems. This contribution will review in a first part the performances of the calorimeter during run 1, obtained from calibration data, and from studies of the response of particles from collisions. In a second part it will present the solutions being investigated for the ongoing and future upgrades of the calorimeter electronics.

The ATLAS Tile Calorimeter

International Nuclear Information System (INIS)

Henriques, A.

2015-01-01

TileCal is the Hadronic calorimeter covering the most central region of the ATLAS experiment at the LHC. It uses iron plates as absorber and plastic scintillating tiles as the active material. Scintillation light produced in the tiles is transmitted by wavelength shifting fibres to photomultiplier tubes (PMTs). The resulting electronic signals from the approximately 10000 PMTs are measured and digitised every 25 ns before being transferred to off-detector data-acquisition systems. This contribution will review in a first part the performances of the calorimeter during run 1, obtained from calibration data, and from studies of the response of particles from collisions. In a second part it will present the solutions being investigated for the ongoing and future upgrades of the calorimeter electronics. (authors)

Polystyrene calorimeter for electron beam dose measurements

DEFF Research Database (Denmark)

Miller, A.

1995-01-01

Calorimeters from polystrene have been constructed for dose measurement at 4-10 MeV electron accelerators. These calorimeters have been used successfully for a few years, and polystyrene calorimeters for use at energies down to 1 MeV and being tested. Advantage of polystyrene as the absorbing...

Performance of the ATLAS hadronic Tile calorimeter

CERN Document Server

Van Daalen, Tal Roelof; The ATLAS collaboration

2018-01-01

Performance of the ATLAS hadronic Tile calorimeter The Tile Calorimeter (TileCal) of the ATLAS experiment at the LHC is the central hadronic calorimeter designed for the reconstruction of hadrons, jets, tau-particles and missing transverse energy. TileCal is a scintillator-steel sampling calorimeter and it covers the region of pseudorapidity < 1.7. The scintillation light produced in the scintillator tiles is transmitted by wavelength shifting fibers to photomultiplier tubes (PMTs). The analog signals from the PMTs are amplified, shaped and digitized every 25 ns by sampling the signal. About 10000 channels of the front-end electronics measure the signals of the calorimeter with energies ranging from ~30 MeV to ~2 TeV. Each step of the signal reconstruction from scintillation light to the digital pulse reconstruction is monitored and calibrated. The performance of the calorimeter has been studied in-situ employing cosmic ray muons and a large sample of proton-proton collisions acquired during the operations...

Last Few Metres for the Barrel Calorimeter

CERN Multimedia

Nyman, T.

On Friday 4th November, the ATLAS Barrel Calorimeter was moved from its assembly point at the side of the ATLAS cavern to the centre of the toroidal magnet system. The detector was finally aligned, to the precision of within a millimetre, on Wednesday 9th November. The ATLAS installation team, led by Tommi Nyman, after having positioned the Barrel Calorimeter in its final location in the ATLAS experimental cavern UX15. The Barrel Calorimeter which will absorb and measure the energy of photons, electrons and hadrons at the core of the ATLAS detector is 8.6 meters in diameter, 6.8 meters long, and weighs over 1600 Tonnes. It consists of two concentric cylindrical detector elements. The innermost comprises aluminium pressure vessels containing the liquid argon electromagnetic calorimeter and the solenoid magnet. The outermost is an assembly of 64 hadron tile calorimeter sectors. Assembled 18 meters away from its final position, the Barrel Calorimeter was relocated with the help of a railway, which allows ...

Central hadron calorimeter of UA1

International Nuclear Information System (INIS)

Corden, M.J.; Dowell, J.D.; Edwards, M.J.

1983-12-01

An iron-scintillator sampling calorimeter is described, which measures hadronic energy in proton-antiproton interactions at the CERN 540 GeV SPS collider. Construction details are given of the instrumentation of the magnet pieces of the UA1 experiment and of the methods used to measure the calorimeter response and resolution. The system of lasers and quartz fibres, which allows long term monitoring of the calorimeter response, is also described. (author)

Central hadron calorimeter of UA1

International Nuclear Information System (INIS)

Corden, M.J.; Dowell, J.D.; Edwards, M.J.; Ellis, N.N.; Garvey, J.; Grant, D.; Homer, R.J.; Kenyon, I.R.; McMahon, T.J.; Schanz, G.; Sumorok, K.C.T.O.; Watkins, P.M.; Wilson, J.A.; Barnes, G.; Bowcock, T.J.V.; Eisenhandler, E.; Gibson, W.R.; Honma, A.K.; Kalmus, P.I.P.; Keeler, R.K.; Pritchard, T.W.; Salvi, G.A.P.; Thompson, G.; Arnison, G.T.J.; Astbury, A.; Cash, A.R.; Grayer, G.H.; Haynes, W.J.; Hill, D.L.; Moore, D.R.; Nandi, A.K.; Percival, M.D.; Roberts, J.H.C.; Scott, W.G.; Shah, T.P.; Stanhope, R.J.; White, D.E.A.

1985-01-01

An iron-scintillator sampling calorimeter is described, which measures hadronic energy in proton-antiproton interactions at the CERN 540 GeV SPS collider. Construction details are given of the instrumentation of the magnet pieces of the UA1 experiment and of the methods used to measure the calorimeter response and resolution. The system of lasers and quartz fibres, which allows long term monitoring of the calorimeter response, is also described. (orig.)

A calorimeter-Faraday cup to measure energy content of ion beams

International Nuclear Information System (INIS)

Luzzi, G.

1984-01-01

A calorimeter-Faraday cup to measure energy content of ion beams is described. It uses an HP quartz thermometer having a 10 -40 C sensitivity; contact potential problems, arising when working with thermocouples, are so avoided. Calibration has been performed with a resistive filament and with an electron beam. The apparatus is profitable if the measured ion beams are constant in time. The measured sensitivity was 10 -40 C/10 -5 W. (author)

Upgrading the Atlas Tile Calorimeter Electronics

CERN Document Server

Popeneciu, G; The ATLAS collaboration

2014-01-01

Tile Calorimeter is the central hadronic calorimeter of the ATLAS experiment at LHC. Around 2024, after the upgrade of the LHC the peak luminosity will increase by a factor of 5 compared to the design value, thus requiring an upgrade of the Tile Calorimeter readout electronics. Except the photomultipliers tubes (PMTs), most of the on- and off-detector electronics will be replaced, with the aim of digitizing all PMT pulses at the front-end level and sending them with 10 Gb/s optical links to the back-end electronics. One demonstrator prototype module is planned to be inserted in Tile Calorimeter in 2015 that will include hybrid electronic components able to probe the new design.

The Phase II Upgrade of the ATLAS Calorimeter

CERN Document Server

Tartarelli, Giuseppe Francesco; The ATLAS collaboration

2017-01-01

This presentation will show the status of the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC). For the HL-LHC, the instantaneous luminosity is expected to increase up to L ≃ 7.5 × 1034 cm−2 s−1 and the average pile-up up to 200 interactions per bunch crossing. The Liquid Argon (LAr) calorimeter electronics will need to be replaced to cope with these challenging conditions: the expected radiation doses will indeed exceed the qualification range of the current readout system, and the upgraded trigger system will require much longer data storage in the electronics (up to 60 us), that the current system cannot sustain. The status of the R&D of the low-power ASICs (pre-amplifier, shaper, ADC, serializer and transmitters) and of the readout electronics design will be discussed. Moreover, a High Granularity Timing Detector (HGTD) is proposed to be added in front of the LAr calorimeters in the end-cap region (2.4 <|eta|< 4.2) for pile-up mitigation a...

Inertial Microfluidic Cell Stretcher (iMCS): Fully Automated, High-Throughput, and Near Real-Time Cell Mechanotyping.

Science.gov (United States)

Deng, Yanxiang; Davis, Steven P; Yang, Fan; Paulsen, Kevin S; Kumar, Maneesh; Sinnott DeVaux, Rebecca; Wang, Xianhui; Conklin, Douglas S; Oberai, Assad; Herschkowitz, Jason I; Chung, Aram J

2017-07-01

Mechanical biomarkers associated with cytoskeletal structures have been reported as powerful label-free cell state identifiers. In order to measure cell mechanical properties, traditional biophysical (e.g., atomic force microscopy, micropipette aspiration, optical stretchers) and microfluidic approaches were mainly employed; however, they critically suffer from low-throughput, low-sensitivity, and/or time-consuming and labor-intensive processes, not allowing techniques to be practically used for cell biology research applications. Here, a novel inertial microfluidic cell stretcher (iMCS) capable of characterizing large populations of single-cell deformability near real-time is presented. The platform inertially controls cell positions in microchannels and deforms cells upon collision at a T-junction with large strain. The cell elongation motions are recorded, and thousands of cell deformability information is visualized near real-time similar to traditional flow cytometry. With a full automation, the entire cell mechanotyping process runs without any human intervention, realizing a user friendly and robust operation. Through iMCS, distinct cell stiffness changes in breast cancer progression and epithelial mesenchymal transition are reported, and the use of the platform for rapid cancer drug discovery is shown as well. The platform returns large populations of single-cell quantitative mechanical properties (e.g., shear modulus) on-the-fly with high statistical significances, enabling actual usages in clinical and biophysical studies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Manipulation of microfluidic droplets by electrorheological fluid

KAUST Repository

Zhang, Menying

2009-09-01

Microfluidics, especially droplet microfluidics, attracts more and more researchers from diverse fields, because it requires fewer materials and less time, produces less waste and has the potential of highly integrated and computer-controlled reaction processes for chemistry and biology. Electrorheological fluid, especially giant electrorheological fluid (GERF), which is considered as a kind of smart material, has been applied to the microfluidic systems to achieve active and precise control of fluid by electrical signal. In this review article, we will introduce recent results of microfluidic droplet manipulation, GERF and some pertinent achievements by introducing GERF into microfluidic system: digital generation, manipulation of "smart droplets" and droplet manipulation by GERF. Once it is combined with real-time detection, integrated chip with multiple functions can be realized. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

The lead-glass electromagnetic calorimeters for the magnetic spectrometers in Hall C at Jefferson Lab

Energy Technology Data Exchange (ETDEWEB)

Mkrtchyan, H. [A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute), Yerevan 0036 (Armenia); Carlini, R. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); Tadevosyan, V., E-mail: tadevosn@jlab.org [A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute), Yerevan 0036 (Armenia); Arrington, J. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Asaturyan, A. [A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute), Yerevan 0036 (Armenia); Christy, M.E. [Hampton University, Hampton, VA 23668 (United States); Dutta, D. [Triangle Universities Nuclear Laboratory and Duke University, Durham, NC 27708 (United States); Ent, R.; Fenker, H.C.; Gaskell, D. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); Horn, T. [Catholic University of America, Washington, DC 20064 (United States); Jones, M.K. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); Keppel, C.E. [Hampton University, Hampton, VA 23668 (United States); Mack, D.J. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); Malace, S.P. [Triangle Universities Nuclear Laboratory and Duke University, Durham, NC 27708 (United States); Mkrtchyan, A. [A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute), Yerevan 0036 (Armenia); Niculescu, M.I. [James Madison University, Harrisonburg, VA 22807 (United States); Seely, J. [Laboratory for Nuclear Science, Massachusetts Institute of Technology, Cambridge, MA (United States); Tvaskis, V. [Hampton University, Hampton, VA 23668 (United States); Wood, S.A. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); and others

2013-08-11

The electromagnetic calorimeters of the various magnetic spectrometers in Hall C at Jefferson Lab are presented. For the existing High Momentum Spectrometer (HMS) and Short Orbit Spectrometer (SOS), design considerations, relevant construction information, and comparisons of simulated and experimental results are included. The energy resolution of the HMS and SOS calorimeters is better than σ/E∼6%/√(E) and pion/electron (π/e) separation of about 100:1 has been achieved in the energy range of 1–5 GeV. Good agreement has been observed between the experimental and simulated energy resolutions, but simulations systematically exceed experimentally determined π{sup −} suppression factors by close to a factor of two. For the Super High Momentum Spectrometer (SHMS), presently under construction, details on the design and accompanying GEANT4 simulation efforts are given. The anticipated performance of the new calorimeter is predicted over the full momentum range of the SHMS. Good electron/hadron separation is anticipated by combining the energy deposited in an initial (preshower) calorimeter layer with the total energy deposited in the calorimeter. -- Highlights: • Construction and performance of lead glass calorimeters in JLab/Hall C are presented. • ∼5%/√(E) resolution, ∼100:1π/e separation is achieved in HMS calorimeter in GeV range. • Simulated resolution of the HMS calorimeter is in good agreement with experiment. • Simulated pion suppression of the HMS calorimeter exceeds experiment, by less than 2. • Pion suppression of ∼400:1 is predicted in projected SHMS calorimeter by simulations.

The CMS Electromagnetic Calorimeter: Construction, Commissioning and Calibration