Evaluation of the BD Max Cdiff assay for the detection of toxigenic Clostridium difficile in human stool specimens.

Science.gov (United States)

Putsathit, Papanin; Morgan, Justin; Bradford, Damien; Engelhardt, Nelly; Riley, Thomas V

2015-02-01

The Becton Dickinson (BD) PCR-based GeneOhm Cdiff assay has demonstrated a high sensitivity and specificity for detecting Clostridium difficile. Recently, the BD Max platform, using the same principles as BD GeneOhm, has become available in Australia. This study aimed to investigate the sensitivity and specificity of BD Max Cdiff assay for the detection of toxigenic C. difficile in an Australian setting. Between December 2013 and January 2014, 406 stool specimens from 349 patients were analysed with the BD Max Cdiff assay. Direct and enrichment toxigenic culture were performed on bioMérieux ChromID C. difficile agar as a reference method. isolates from specimens with discrepant results were further analysed with an in-house PCR to detect the presence of toxin genes. The overall prevalence of toxigenic C. difficile was 7.2%. Concordance between the BD Max assay and enrichment culture was 98.5%. The sensitivity, specificity, positive predictive value and negative predictive value for the BD Max Cdiff assay were 95.5%, 99.0%, 87.5% and 99.7%, respectively, when compared to direct culture, and 91.7%, 99.0%, 88.0% and 99.4%, respectively, when compared to enrichment culture. The new BD Max Cdiff assay appeared to be an excellent platform for rapid and accurate detection of toxigenic C. difficile.

Size-sensitive particle trajectories in three-dimensional micro-bubble acoustic streaming flows

Science.gov (United States)

Volk, Andreas; Rossi, Massimiliano; Hilgenfeldt, Sascha; Rallabandi, Bhargav; Kähler, Christian; Marin, Alvaro

2015-11-01

Oscillating microbubbles generate steady streaming flows with interesting features and promising applications for microparticle manipulation. The flow around oscillating semi-cylindrical bubbles has been typically assumed to be independent of the axial coordinate. However, it has been recently revealed that particle motion is strongly three-dimensional: Small tracer particles follow vortical trajectories with pronounced axial displacements near the bubble, weaving a toroidal stream-surface. A well-known consequence of bubble streaming flows is size-dependent particle migration, which can be exploited for sorting and trapping of microparticles in microfluidic devices. In this talk, we will show how the three-dimensional toroidal topology found for small tracer particles is modified as the particle size increases up to 1/3 of the bubble radius. Our results show size-sensitive particle positioning along the axis of the semi-cylindrical bubble. In order to analyze the three-dimensional sorting and trapping capabilities of the system, experiments with an imposed flow and polydisperse particle solutions are also shown.

PND fuel handling decontamination program: specialized techniques and results

International Nuclear Information System (INIS)

Pan, R.; Hobbs, K.; Minnis, M.; Graham, K.

1995-01-01

The use of various decontamination techniques and equipment has become a critical part of Fuel Handling maintenance work at the Pickering Nuclear Station, an eight unit CANDU station located about 30 km east of Toronto. This paper presents an overview of the set up and techniques used for cleaning in the PND Fuel Handling Maintenance Facility, and the results achieved. (author)

Dynamics of bubble formation in highly viscous liquids.

Science.gov (United States)

Pancholi, Ketan; Stride, Eleanor; Edirisinghe, Mohan

2008-04-15

There has recently been considerable interest in the development of devices for the preparation of monodisperse microbubble suspensions for use as ultrasound contrast agents and drug delivery vehicles. These applications require not only a high degree of bubble uniformity but also a maximum bubble size of 8 mum, and this provides a strong motivation for developing an improved understanding of the process of bubble formation in a given device. The aim of this work was to investigate bubble formation in a T-junction device and determine the influence of the different processing parameters upon bubble size, in particular, liquid viscosity. Images of air bubble formation in a specially designed T-junction were recorded using a high-speed camera for different ratios of liquid to gas flow rate (Ql/Qg) and different liquid viscosities (microl). It was found that theoretical predictions of the flow profile in the focal region based on analysis of axisymmetric Stokes flow were accurate to within 6% when compared with the experimental data, indicating that this provided a suitable means of describing the bubble formation process. Both the theoretical and experimental results showed that Ql/Qg and mul had a significant influence upon bubble formation and eventual size, with higher flow rates and higher viscosities producing smaller bubbles. There were, however, found to be limiting values of Ql/Qg and mul beyond which no further reduction in bubble size was achieved.

A grid-independent EMMS/bubbling drag model for bubbling and turbulent fluidization

DEFF Research Database (Denmark)

Luo, Hao; Lu, Bona; Zhang, Jingyuan

2017-01-01

The EMMS/bubbling drag model takes the effects of meso-scale structures (i.e. bubbles) into modeling of drag coefficient and thus improves coarse-grid simulation of bubbling and turbulent fluidized beds. However, its dependence on grid size has not been fully investigated. In this article, we adopt...... a two-step scheme to extend the EMMS/bubbling model to the sub-grid level. Thus the heterogeneity index, HD, which accounts for the hydrodynamic disparity between homogeneous and heterogeneous fluidization, can be correlated as a function of both local voidage and slip velocity. Simulations over...... a periodic domain show the new drag model is less sensitive to grid size because of the additional dependence on local slip velocity. When applying the new drag model to simulations of realistic bubbling and turbulent fluidized beds, we find grid-independent results are easier to obtain for high...

Observation of high-temperature bubbles in an ECR plasma

Science.gov (United States)

Terasaka, K.; Yoshimura, S.; Tanaka, M. Y.

2018-05-01

Creation and annihilation of high-temperature bubbles have been observed in an electron cyclotron resonance plasma. The electron temperature in the bubble core is three times higher than that in the ambient region, and the size perpendicular to the magnetic field is much smaller than the plasma diameter. Formation of a bubble accompanies large negative spikes in the floating potential of a Langmuir probe, and the spatiotemporal behavior of the bubble has been visualized with a high-impedance wire grid detector. It is found that the bubble is in a prolate spheroidal shape with the axis along the magnetic field and occurs randomly in time and independently in space.

Altered response to A(H1N1)pnd09 vaccination in pregnant women

DEFF Research Database (Denmark)

Bischoff, Anne Louise; Følsgaard, Nilofar Vahman; Carson, Charlotte Giwercman

2013-01-01

BACKGROUND: Pregnant women were suspected to be at particular risk when H1N1pnd09 influenza became pandemic in 2009. Our primary objective was to compare the immune responses conferred by MF59®-adjuvanted vaccine (Focetria®) in H1N1pnd09-naïve pregnant and non-pregnant women. The secondary aims...... were to compare influences of dose and adjuvant on the immune response. METHODS: The study was nested in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010) pregnancy cohort in 2009-2010 and conducted as a single-blinded block-randomised [1∶1∶1] controlled clinical trial in pregnant...... women after gestational week 20: (1) 7.5 µg H1N1pnd09 antigen with MF59-adjuvant (Pa7.5 µg); (2) 3.75 µg antigen half MF59-adjuvanted (Pa3.75 µg); (3) 15 µg antigen unadjuvanted (P15 µg); and in non-pregnant women receiving (4) 7.5 µg antigen full adjuvanted (NPa7.5 µg). Blood samples were collected...

Some investigations on the mean and fluctuating velocities of an oscillating Taylor bubble

International Nuclear Information System (INIS)

Madani, Sara; Caballina, Ophelie; Souhar, Mohamed

2012-01-01

Highlights: ► The unsteady motion of an oscillating Taylor bubble has been studied. ► A non-dimensionalized velocity differential equation is numerically solved. ► The role of dimensionless numbers on the dynamics of the bubble is highlighted. ► Mean and fluctuating velocities and the phase shift are experimentally investigated. ► Correlations allowing the prediction of these latter parameters are proposed. - Abstract: The slug flow characterized by large elongated bubbles also called Taylor bubbles is widely encountered in nuclear reactor steam generators, cooling plants, reboilers, etc. The analysis of slug flow is very important as the instability caused by such flows can affect the safety features of nuclear reactors and other two-phase flow equipments. In this paper, we study the motion of a Taylor bubble rising in stagnant fluids in a vertical oscillating pipe. The investigation is restricted to high Reynolds numbers and to an intermediate range of Bond numbers where the effects of surface tension can be considered. The Froude number ranged between 0.22 and 0.33. Firstly, detailed analysis of models proposed in the literature for the motion of a Taylor bubble in an unsteady acceleration field is realized. The velocity differential equation obtained in the case of potential and axisymmetric flow without surface tension given in the literature is first non-dimensionalized to highlight dimensionless numbers. Then, the instantaneous velocity of the bubble is numerically determined. Mean and fluctuating velocities as well as the phase shift (U ¯ b , U f and φ) are estimated by using a technique based on the nonlinear least squares method. Results enable a discussion on the role played by dimensionless numbers on the dynamics of the bubble. It is found that the two parameters, the relative acceleration and the Bond number (a and Bo) have a governing role on the evolution of mean and fluctuating velocities while the ratio of the oscillation amplitude to

Holography in small bubble chambers

International Nuclear Information System (INIS)

Lecoq, P.

1984-01-01

This chapter reports on an experiment to determine the total charm cross section at different incident momenta using the small, heavy liquid bubble chamber HOBC. Holography in liquid hydrogen is also tested using the holographic lexan bubble chamber HOLEBC with the aim of preparing a future holographic experiment in hydrogen. The high intensity tests show that more than 100 incident tracks per hologram do not cause a dramatic effect on the picture quality. Hydrogen is more favorable than freon as the bubble growth is much slower in hydrogen. An advantage of holography is to have the maximum resolution in the full volume of the bubble chamber, which allows a gain in sensitivity by a factor of 10 compared to classical optics as 100 tracks per hologram look reasonable. Holograms are not more difficult to analyze than classical optics high-resolution pictures. The results show that holography is a very powerful technique which can be used in very high resolution particle physics experiments

Experimental research of neutron yield and spectrum from deuterium gas-puff z-pinch on the GIT-12 generator at current above 2 MA

Science.gov (United States)

Cherdizov, R. K.; Fursov, F. I.; Kokshenev, V. A.; Kurmaev, N. E.; Labetsky, A. Yu; Ratakhin, N. A.; Shishlov, A. V.; Cikhardt, J.; Cikhardtova, B.; Klir, D.; Kravarik, J.; Kubes, P.; Rezac, K.; Dudkin, G. N.; Garapatsky, A. A.; Padalko, V. N.; Varlachev, V. A.

2017-05-01

The Z-pinch experiments with deuterium gas-puff surrounded by an outer plasma shell were carried out on the GIT-12 generator (Tomsk, Russia) at currents of 2 MA. The plasma shell consisting of hydrogen and carbon ions was formed by 48 plasma guns. The deuterium gas-puff was created by a fast electromagnetic valve. This configuration provides an efficient mode of the neutron production in DD reaction, and the neutron yield reaches a value above 1012 neutrons per shot. Neutron diagnostics included scintillation TOF detectors for determination of the neutron energy spectrum, bubble detectors BD-PND, a silver activation detector, and several activation samples for determination of the neutron yield analysed by a Sodium Iodide (NaI) and a high-purity Germanium (HPGe) detectors. Using this neutron diagnostic complex, we measured the total neutron yield and amount of high-energy neutrons.

Using Design Sketch to Teach Bubble Sort in High School

OpenAIRE

Liu, Chih-Hao; Jiu, Yi-Wen; Chen, Jason Jen-Yen

2009-01-01

Bubble Sort is simple. Yet, it seems a bit difficult for high school students. This paper presents a pedagogical methodology: Using Design Sketch to visualize the concepts in Bubble Sort, and to evaluate how this approach assists students to understand the pseudo code of Bubble Sort. An experiment is conducted in Wu-Ling Senior High School with 250 students taking part. The statistical analysis of experimental results shows that, for relatively high abstraction concepts, such as iteration num...

BD+43° 3654 - a blue straggler?

Science.gov (United States)

Gvaramadze, V. V.; Bomans, D. J.

2008-07-01

The astrometric data on the runaway star BD+43° 3654 are consistent with the origin of this O4If star in the center of the Cyg OB2 association, while BD+43° 3654 is younger than the association. To reconcile this discrepancy, we suggest that BD+43° 3654 is a blue straggler formed via a close encounter between two tight massive binaries in the core of Cyg OB2. A possible implication of this suggestion is that the very massive (and therefore apparently very young) stars in Cyg OB2 could be blue stragglers as well. We also suggest that the binary-binary encounter producing BD+43° 3654 might be responsible for ejection of two high-velocity stars (the stripped helium cores of massive stars) - the progenitors of the pulsars B2020+28 and B2021+51.

A model established of a 'Embryo' bubble growing-up some visible bubble in bubble chamber and its primary theory calculation

International Nuclear Information System (INIS)

Ye Zipiao; Sheng Xiangdong

2006-01-01

A model of a 'embryo' bubble growing up a visible bubble in the bubble chamber is established. Through primary theory calculation it is shown that the 'embryo' bubble is not only absorbing quantity of heat, but also some molecules get into the 'embryo' bubble from its environment. It is explained reasonably that the radius of bubbles in bubble camber is different for the same energies of neutrons and proton. The track of neutron in bubble camber is long and thin, and the track of proton in bubble camber is wide and short. It is explained reasonably that the bubble radius of the incident particles with more charges which there are the same energies will be wider than that of the incident particles with less charges in the track. It is also explained reasonably that there are a little different radius of the bubbles of a track at the some region. It can be predicted theoretically that there should be big bubbles to burst when incident particles enter the bubble chamber at first. The sensitivity and the detective efficiency of bubble camber can be enhanced by choosing appropriate work matter. (authors)

Semi-automatic bubble counting system for superheated droplet detectors

International Nuclear Information System (INIS)

Reina, Luiz C.; Bellido, Luis F.; Ramos, Paulo R.; Silva, Ademir X. da; Facure, Alessandro; Dantas, Jose E.R.

2009-01-01

Neutron dose rate measurements are normally performed by means of PADC, CR-39 and TLD detectors. Although, none of these devices can give instant reading of the neutron dose, recently new kind of detectors are being developed, based on the formation of tiny drops in a superheated liquid suspended in a polymer or gel solution, called superheated droplet detector (SDD) or also as bubble detectors (BD), with no response for gamma radiation. This work describes the experimental setup and the developed procedures for acquiring and processing digital images obtained with bubble detector spectrometer (BDS), developed by Bubble Technology Industries, for personal neutron dosimeter and/or neutron energy fluence measurements in nuclear facilities. The results of the neutron measurements obtained during the F-18 production, at the RDS-111 cyclotron, are presented. These neutron measurements were the first ones with this type of BDS detectors in a particle accelerator facility in Brazil and it was very important to estimate neutron dose rate received by occupationally exposed individuals. (author)

Study of Bubble Size, Void Fraction, and Mass Transport in a Bubble Column under High Amplitude Vibration

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Shahrouz Mohagheghian

2018-04-01

Full Text Available Vertical vibration is known to cause bubble breakup, clustering and retardation in gas-liquid systems. In a bubble column, vibration increases the mass transfer ratio by increasing the residence time and phase interfacial area through introducing kinetic buoyancy force (Bjerknes effect and bubble breakup. Previous studies have explored the effect of vibration frequency (f, but minimal effort has focused on the effect of amplitude (A on mass transfer intensification. Thus, the current work experimentally examines bubble size, void fraction, and mass transfer in a bubble column under relatively high amplitude vibration (1.5 mm < A <9.5 mm over a frequency range of 7.5–22.5 Hz. Results of the present work were compared with past studies. The maximum stable bubble size under vibration was scaled using Hinze theory for breakage. Results of this work indicate that vibration frequency exhibits local maxima in both mass transfer and void fraction. Moreover, an optimum amplitude that is independent of vibration frequency was found for mass transfer enhancements. Finally, this work suggests physics-based models to predict void fraction and mass transfer in a vibrating bubble column.

Bubble dynamics and bubble-induced turbulence of a single-bubble chain

Science.gov (United States)

Lee, Joohyoung; Park, Hyungmin

2016-11-01

In the present study, the bubble dynamics and liquid-phase turbulence induced by a chain of bubbles injected from a single nozzle have been experimentally investigated. Using a high-speed two-phase particle image velociemtry, measurements on the bubbles and liquid-phase velocity field are conducted in a transparent tank filled with water, while varying the bubble release frequency from 0.1 to 35 Hz. The tested bubble size ranges between 2.0-3.2 mm, and the corresponding bubble Reynolds number is 590-1100, indicating that it belongs to the regime of path instability. As the release frequency increases, it is found that the global shape of bubble dispersion can be classified into two regimes: from asymmetric (regular) to axisymmetric (irregular). In particular, at higher frequency, the wake vortices of leading bubbles cause an irregular behaviour of the following bubble. For the liquid phase, it is found that a specific trend on the bubble-induced turbulence appears in a strong relation to the above bubble dynamics. Considering this, we try to provide a theoretical model to estimate the liquid-phase turbulence induced by a chain of bubbles. Supported by a Grant funded by Samsung Electronics, Korea.

Acoustic characteristics of bubble bursting at the surface of a high-viscosity liquid

International Nuclear Information System (INIS)

Liu Xiao-Bo; Zhang Jian-Run; Li Pu

2012-01-01

An acoustic pressure model of bubble bursting is proposed. An experiment studying the acoustic characteristics of the bursting bubble at the surface of a high-viscosity liquid is reported. It is found that the sudden bursting of a bubble at the high-viscosity liquid surface generates N-shape wave at first, then it transforms into a jet wave. The fundamental frequency of the acoustic signal caused by the bursting bubble decreases linearly as the bubble size increases. The results of the investigation can be used to understand the acoustic characteristics of bubble bursting. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

Vapor bubble growth in highly superheated liquid

International Nuclear Information System (INIS)

Pavlov, P.A.

1981-01-01

Dynamics of the bubble growth in the volume of the uniformally superheated liquid is considered. It is supposed that its growth is hampered by heat transfer. An asymptotic expression for the bubble growth rate at high superheatings when heat hold by liquid is comparable with heat of steam formation, is found by the automodel solution of the heat transfer equation. Writing the radius square in the form of a functional applicable for the calculation of steam formation at the pressure change in superheated liquid is suggested for eveluation calculations [ru

Investigation of bubble flow regimes in nucleate boiling of highly-wetting liquids

International Nuclear Information System (INIS)

Tong, W.; Bar-Cohen, A.; Simon, T.W.

1991-01-01

This paper describes an investigation of the bubble flow regimes in nucleate boiling of FC-72, a highly-wetting liquid. Theoretically analysis of vapor bubble generation and departure from the heated surface reveals that the heat fluxes required for the merging of consecutive bubbles, for highly-wetting liquids, lie in the upper range of the nucleate boiling heat flux. A visual and photographic study of nucleate boiling from sputtered platinum surfaces has supported the theoretical results and shown that the isolated bubble behavior extends to at least 50-80% of the critical heat flux, considerably higher than observed by others with water. Lateral coalescence of adjacent bubbles has been found to be a more likely cause of the termination of the isolated bubble regime. These findings suggest that thermal transport models which are based on isolated bubble behavior may be applicable to nearly the entire range of nucleate boiling of electronic cooling fluids

Hydrogen bubble dynamic template fabrication of nanoporous Cu film supported by graphene nanaosheets: A highly sensitive sensor for detection of nitrite.

Science.gov (United States)

Majidi, Mir Reza; Ghaderi, Seyran

2017-12-01

High surface area nanoporous Cu film (NPCF) has been successfully synthesized using a hydrogen bubble dynamic template on the graphene nanosheets (GNs) modified glassy carbon electrode (GCE). The effect of different synthesis conditions such as applied potential and deposition time on the NPCF morphology was investigated. The structure and constituent of the NPCF-GNs/GCE were characterized by scanning electron microscopy (SEM), energy-dispersive x-ray (EDX), X-ray diffraction (XRD), electrochemical impedance spectroscopy (EIS) and electrochemical methods. The study on electrocatalytic performance of the NPCF-GNs/GCE demonstrated that this electrode has excellent catalytic activity toward nitrite oxidation. The quantitative measurement of nitrite by amperometric method showed a wide concentration range (0.1-100µmolL -1 ) with a detection limit and a sensitivity of 8.87 × 10 -8 molL -1 and 3.1 AL/molcm 2 , respectively. The excellent electrochemical response and high sensitivity of the proposed electrode were attributed to the 3D structure of NPCF and the synergic effect of NPCF and GNs. Furthermore, this electrode showed some other advantages including good repeatability, high reproducibility, long-term stability and anti-interference performance toward nitrite sensing. The applicability of the proposed electrode was proved by successful determination of nitrite in real samples (tap water, river water and sausage samples). Copyright © 2017 Elsevier B.V. All rights reserved.

Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

Directory of Open Access Journals (Sweden)

Girolamo Jose Barrera

2013-09-01

Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent caries

Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

Directory of Open Access Journals (Sweden)

Girolamo Jose Barrera

2013-09-01

Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p < 0.01.Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent

Analysis of bubble pressure in the rim region of high burnup PWR fuel

Energy Technology Data Exchange (ETDEWEB)

Koo, Yang Hyun; Lee, Byung Ho; Sohn, Dong Seong [Korea Atomic Energy Research Institute, Taejeon (Korea)

2000-02-01

Bubble pressure in the rim region of high burnup PWR UO{sub 2} fuel has been modeled based on measured rim width, porosity and bubble density. Using the assumption that excessive bubble pressure in the rim is inversely proportional to its radius, proportionality constant is derived as a function of average pellet burnup and bubble radius. This approach is possible because the integration of the number of Xe atoms retained in the rim bubbles, which can be calculated as a function of bubble radius, over the bubble radius gives the total number of Xe atoms in the rim bubbles. Here the total number of Xe atoms in the rim bubbles can be derived from the measured Xe depletion fraction in the matrix and the calculated rim thickness. Then the rim bubble pressure is obtained as a function of fuel burnup and bubble size from the proportionality constant. Therefore, the present model can provide some useful information that would be required to analyze the behavior of high burnup PWR UO{sub 2} fuel under both normal and transient operating conditions. 28 refs., 9 figs. (Author)

Widespread occurrence of bd in French Guiana, South America.

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Elodie A Courtois

Full Text Available The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1 determine its geographical distribution, (2 test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera to define sentinel species for future work, (3 track changes in prevalence through time and (4 determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012. At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4% as compared to Bufonidae (2.6 % and Hylidae (1.5%. In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

Elevated Corticosterone Levels and Changes in Amphibian Behavior Are Associated with Batrachochytrium dendrobatidis (Bd Infection and Bd Lineage.

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Caitlin R Gabor

Full Text Available Few studies have examined the role hormones play in mediating clinical changes associated with infection by the parasite Batrachochytrium dendrobatidis (Bd. Glucocorticoid (GC hormones such as corticosteroids (CORT regulate homeostasis and likely play a key role in response to infection in amphibians. We explore the relationship between CORT release rates and Bd infection in tadpoles of the common midwife toad, Alytes obstetricians, using a non-invasive water-borne hormone collection method across seven populations. We further examined whether tadpoles of A. muletensis infected with a hypervirulent lineage of Bd, BdGPL, had greater CORT release rates than those infected with a hypovirulent lineage, BdCAPE. Finally, we examined the relationship between righting reflex and CORT release rates in infected metamorphic toads of A. obstetricans. We found an interaction between elevation and Bd infection status confirming that altitude is associated with the overall severity of infection. In tandem, increasing elevation was associated with increasing CORT release rates. Tadpoles infected with the hypervirulent BdGPL had significantly higher CORT release rates than tadpoles infected with BdCAPE showing that more aggressive infections lead to increased CORT release rates. Infected metamorphs with higher CORT levels had an impaired righting reflex, our defined experimental endpoint. These results provide evidence that CORT is associated with an amphibian's vulnerability to Bd infection, and that CORT is also affected by the aggressiveness of infection by Bd. Together these results indicate that CORT is a viable biomarker of amphibian stress.

Utilization of plant-derived recombinant human β-defensins (hBD-1 and hBD-2) for averting salmonellosis.

Science.gov (United States)

Patro, Sunita; Maiti, Soumitra; Panda, Santosh Kumar; Dey, Nrisingha

2015-04-01

We describe the use of plant-made β-defensins as effective antimicrobial substances for controlling salmonellosis, a deadly infection caused by Salmonella typhimurium (referred to further as S. typhi). Human β-defensin-1 (hBD-1) and -2 (hBD-2) were expressed under the control of strong constitutive promoters in tobacco plants, and bio-active β-defensins were successfully extracted. In the in vitro studies, enriched recombinant plant-derived human β-defensin-1 (phBD-1) and -2 (phBD-2) obtained from both T1 and T2 transgenic plants showed significant antimicrobial activity against Escherichia coli and S. typhi when used individually and in various combinations. The 2:1 peptide combination of phBD-1:phBD-2 with peptides isolated from T1-and T2-generation plants reduced the growth of S. typhi by 96 and 85 %, respectively. In vivo studies employing the mouse model (Balb/c) of Salmonella infection clearly demonstrated that the administration of plant-derived defensins individually and in different combinations enhanced the mean survival time of Salmonella-infected animals. When treatment consisted of the 2:1 phBD-1:phBD-2 combination, approximately 50 % of the infected mice were still alive at 206 h post-inoculation; the lowest number of viable S. typhi was observed in the liver and spleen of infected animals. We conclude that plant-made recombinant β-defensins (phBD-1 and phBD-2) are promising antimicrobial substances and have the potential to become additional tools against salmonellosis, particularly when used in combination.

High Milk-Clotting Activity Expressed by the Newly Isolated Paenibacillus spp. Strain BD3526

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Feng Hang

2016-01-01

Full Text Available Paenibacillus spp. BD3526, a bacterium exhibiting a protein hydrolysis circle surrounded with an obvious precipitation zone on skim milk agar, was isolated from raw yak (Bos grunniens milk collected in Tibet, China. Phylogenetic analysis based on 16S rRNA and whole genome sequence comparison indicated the isolate belong to the genus Paenibacillus. The strain BD3526 demonstrated strong ability to produce protease with milk clotting activity (MCA in wheat bran broth. The protease with MCA was predominantly accumulated during the late-exponential phase of growth. The proteolytic activity (PA of the BD3526 protease was 1.33-fold higher than that of the commercial R. miehei coagulant. A maximum MCA (6470 ± 281 SU mL−1 of the strain BD3526 was reached under optimal cultivation conditions. The protease with MCA was precipitated from the cultivated supernatant of wheat bran broth with ammonium sulfate and purified by anion-exchange chromatography. The molecular weight of the protease with MCA was determined as 35 kDa by sodium dodecyl sulfate-polyacrylamide gels electrophoresis (SDS-PAGE and gelatin zymography. The cleavage site of the BD3526 protease with MCA in κ-casein was located at the Met106–Ala107 bond, as determined by mass spectrometry analysis.

Numerical Study on Mass Transfer of a Vapor Bubble Rising in Very High Viscous Fluid

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T. Kunugi

2014-09-01

Full Text Available This study focused on a bubble rising behavior in a molten glass because it is important to improve the efficiency of removal of bubbles from the molten glass. On the other hand, it is expected that some gas species which exists in a bubble are transferred into the molten glass through the bubble interface, i.e., the mass transfer, subsequently, it may cause a bubble contraction in the molten glass. In this paper, in order to understand the bubble rising behavior with its contraction caused by the mass transfer through the bubble interface in the very high viscous fluid such as the molten glass, a bubble contraction model has been developed. The direct numerical simulations based on the MARS (Multi-interface Advection and Reconstruction Solver coupled with the mass transfer equation and the bubble contraction model regarding the mass transfer from the rising bubble in very high viscous fluid have been performed. Here, the working fluids were water vapor as the gas species and the molten glass as the very high viscous fluid. Also, the jump conditions at the bubble interface for the mass transfer were examined. Furthermore, the influence of the bubble contraction for the bubble rising compared to that in the water as a normal viscous fluid was investigated. From the result of the numerical simulations, it was found that the bubble rising behavior was strongly affected not only by the viscosity of the working fluid but also by the bubble contraction due to the mass transfer through the bubble interface.

Characterization of Bubble Size Distributions within a Bubble Column

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Shahrouz Mohagheghian

2018-02-01

Full Text Available The current study experimentally examines bubble size distribution (BSD within a bubble column and the associated characteristic length scales. Air was injected into a column of water via a single injection tube. The column diameter (63–102 mm, injection tube diameter (0.8–1.6 mm and superficial gas velocity (1.4–55 mm/s were varied. Large samples (up to 54,000 bubbles of bubble sizes measured via 2D imaging were used to produce probability density functions (PDFs. The PDFs were used to identify an alternative length scale termed the most frequent bubble size (dmf and defined as the peak in the PDF. This length scale as well as the traditional Sauter mean diameter were used to assess the sensitivity of the BSD to gas injection rate, injector tube diameter, injection tube angle and column diameter. The dmf was relatively insensitive to most variation, which indicates these bubbles are produced by the turbulent wakes. In addition, the current work examines higher order statistics (standard deviation, skewness and kurtosis and notes that there is evidence in support of using these statistics to quantify the influence of specific parameters on the flow-field as well as a potential indicator of regime transitions.

Taylor bubbles at high viscosity ratios: experiments and numerical simulations

Science.gov (United States)

Hewakandamby, Buddhika; Hasan, Abbas; Azzopardi, Barry; Xie, Zhihua; Pain, Chris; Matar, Omar

2015-11-01

The Taylor bubble is a single long bubble which nearly fills the entire cross section of a liquid-filled circular tube, often occurring in gas-liquid slug flows in many industrial applications, particularly oil and gas production. The objective of this study is to investigate the fluid dynamics of three-dimensional Taylor bubble rising in highly viscous silicone oil in a vertical pipe. An adaptive unstructured mesh modelling framework is adopted here which can modify and adapt anisotropic unstructured meshes to better represent the underlying physics of bubble rising and reduce computational effort without sacrificing accuracy. The numerical framework consists of a mixed control volume and finite element formulation, a `volume of fluid'-type method for the interface-capturing based on a compressive control volume advection method, and a force-balanced algorithm for the surface tension implementation. Experimental results for the Taylor bubble shape and rise velocity are presented, together with numerical results for the dynamics of the bubbles. A comparison of the simulation predictions with experimental data available in the literature is also presented to demonstrate the capabilities of our numerical method. EPSRC Programme Grant, MEMPHIS, EP/K0039761/1.

Numerical simulation of high Reynolds number bubble motion

Energy Technology Data Exchange (ETDEWEB)

McLaughlin, J.B. [Clarkson Univ., Potsdam, NY (United States)

1995-12-31

This paper presents the results of numerical simulations of bubble motion. All the results are for single bubbles in unbounded fluids. The liquid phase is quiescent except for the motion created by the bubble, which is axisymmetric. The main focus of the paper is on bubbles that are of order 1 mm in diameter in water. Of particular interest is the effect of surfactant molecules on bubble motion. Results for the {open_quotes}insoluble surfactant{close_quotes} model will be presented. These results extend research by other investigators to finite Reynolds numbers. The results indicate that, by assuming complete coverage of the bubble surface, one obtains good agreement with experimental observations of bubble motion in tap water. The effect of surfactant concentration on the separation angle is discussed.

Laser-Generated Shocks and Bubbles as Laboratory-Scale Models of Underwater Explosions

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Theodore G. Jones

2003-01-01

Full Text Available Underwater shocks and bubbles were generated using a high energy pulsed laser system. The advantages of this experimental approach are: (1 precisely controlled and measured experimental conditions; (2 improved diagnostics, including extensive imaging capabilities; (3 unique experiments, including a simultaneously detonated line charge; and (4 the ability to provide validation quality data for hydrodynamic simulation codes. Bubble sensitivity to variation of several experimental parameters was examined. Numerical simulations were performed corresponding to the experimental shots, showing that empirical bubble theory, experimental bubble data, and simulations were all in good agreement.

Astrometric studies of the regions BD + 17 degree 4946, BD -5 degree 3071, and Ross 730-1

International Nuclear Information System (INIS)

Russell, J.; Gatewood, G.

1975-01-01

Positions, proper motions, and absolute parallaxes were found for 46 stars in the regions of BD +17 degree4946, BD -5 degree3071, and Ross 730-1. BD +17 degree4946 showed some evidence of irregular variations in position and magnitude. The residuals for Ross 730-1 were used in a preliminary study to test for an appropriate weighting system; a weak weighting system was indicated. (auth)

Network single-walled carbon nanotube biosensors for fast and highly sensitive detection of proteins

International Nuclear Information System (INIS)

Hu Pingan; Zhang Jia; Wen Zhenzhong; Zhang Can

2011-01-01

Detection of proteins is powerfully assayed in the diagnosis of diseases. A strategy for the development of an ultrahigh sensitivity biosensor based on a network single-walled carbon nanotube (SWNT) field-effect transistor (FET) has been demonstrated. Metallic SWNTs (m-SWNTs) in the network nanotube FET were selectively removed or cut via a carefully controlled procedure of electrical break-down (BD), and left non-conducting m-SWNTs which magnified the Schottky barrier (SB) area. This nanotube FET exhibited ultrahigh sensitivity and fast response to biomolecules. The lowest detection limit of 0.5 pM was achieved by exploiting streptavidin (SA) or a biotin/SA pair as the research model, and BD-treated nanotube biosensors had a 2 x 10 4 -fold lower minimum detectable concentration than the device without BD treatment. The response time is in the range of 0.3-3 min.

Optical nucleation of bubble clouds in a high pressure spherical resonator.

Science.gov (United States)

Anderson, Phillip; Sampathkumar, A; Murray, Todd W; Gaitan, D Felipe; Glynn Holt, R

2011-11-01

An experimental setup for nucleating clouds of bubbles in a high-pressure spherical resonator is described. Using nanosecond laser pulses and multiple phase gratings, bubble clouds are optically nucleated in an acoustic field. Dynamics of the clouds are captured using a high-speed CCD camera. The images reveal cloud nucleation, growth, and collapse and the resulting emission of radially expanding shockwaves. These shockwaves are reflected at the interior surface of the resonator and then reconverge to the center of the resonator. As the shocks reconverge upon the center of the resonator, they renucleate and grow the bubble cloud. This process is repeated over many acoustic cycles and with each successive shock reconvergence, the bubble cloud becomes more organized and centralized so that subsequent collapses give rise to stronger, better defined shockwaves. After many acoustic cycles individual bubbles cannot be distinguished and the cloud is then referred to as a cluster. Sustainability of the process is ultimately limited by the detuning of the acoustic field inside the resonator. The nucleation parameter space is studied in terms of laser firing phase, laser energy, and acoustic power used.

78 FR 11089 - Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick...

Science.gov (United States)

2013-02-15

...; Special Conditions No. 25-477-SC] Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500... special conditions. SUMMARY: These special conditions are issued for the Bombardier Aerospace Model BD-500...: Background On December 10, 2009, Bombardier Aerospace applied for a type certificate for their new Model BD...

Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

Directory of Open Access Journals (Sweden)

Wanyi Li

2014-03-01

Full Text Available Influenza (flu pandemics have exhibited a great threat to human health throughout history. With the emergence of drug-resistant strains of influenza A virus (IAV, it is necessary to look for new agents for treatment and transmission prevention of the flu. Defensins are small (2–6 kDa cationic peptides known for their broad-spectrum antimicrobial activity. Beta-defensins (β-defensins are mainly produced by barrier epithelial cells and play an important role in attacking microbe invasion by epithelium. In this study, we focused on the anti-influenza A virus activity of mouse β-defensin 1 (mBD1 and β defensin-3 (mBD3 by synthesizing their fusion peptide with standard recombinant methods. The eukaryotic expression vectors pcDNA3.1(+/mBD1-mBD3 were constructed successfully by overlap-PCR and transfected into Madin-Darby canine kidney (MDCK cells. The MDCK cells transfected by pcDNA3.1(+/mBD1-mBD3 were obtained by G418 screening, and the mBD1-mBD3 stable expression pattern was confirmed in MDCK cells by RT-PCR and immunofluorescence assay. The acquired stable transfected MDCK cells were infected with IAV (A/PR/8/34, H1N1, 0.1 MOI subsequently and the virus titers in cell culture supernatants were analyzed by TCID50 72 h later. The TCID50 titer of the experimental group was clearly lower than that of the control group (p < 0.001. Furthermore, BALB/C mice were injected with liposome-encapsulated pcDNA3.1(+/mBD1-mBD3 through muscle and then challenged with the A/PR/8/34 virus. Results showed the survival rate of 100% and lung index inhibitory rate of 32.6% in pcDNA3.1(+/mBD1-mBD3group; the TCID50 titer of lung homogenates was clearly lower than that of the control group (p < 0.001. This study demonstrates that mBD1-mBD3 expressed by the recombinant plasmid pcDNA3.1(+/mBD1-mBD3 could inhibit influenza A virus replication both in vitro and in vivo. These observations suggested that the recombinant mBD1-mBD3 might be developed into an agent for

High Efficiency Hydrodynamic DNA Fragmentation in a Bubbling System.

Science.gov (United States)

Li, Lanhui; Jin, Mingliang; Sun, Chenglong; Wang, Xiaoxue; Xie, Shuting; Zhou, Guofu; van den Berg, Albert; Eijkel, Jan C T; Shui, Lingling

2017-01-18

DNA fragmentation down to a precise fragment size is important for biomedical applications, disease determination, gene therapy and shotgun sequencing. In this work, a cheap, easy to operate and high efficiency DNA fragmentation method is demonstrated based on hydrodynamic shearing in a bubbling system. We expect that hydrodynamic forces generated during the bubbling process shear the DNA molecules, extending and breaking them at the points where shearing forces are larger than the strength of the phosphate backbone. Factors of applied pressure, bubbling time and temperature have been investigated. Genomic DNA could be fragmented down to controllable 1-10 Kbp fragment lengths with a yield of 75.30-91.60%. We demonstrate that the ends of the genomic DNAs generated from hydrodynamic shearing can be ligated by T4 ligase and the fragmented DNAs can be used as templates for polymerase chain reaction. Therefore, in the bubbling system, DNAs could be hydrodynamically sheared to achieve smaller pieces in dsDNAs available for further processes. It could potentially serve as a DNA sample pretreatment technique in the future.

Formation and evolution of bubbly screens in confined oscillating bubbly liquids

Science.gov (United States)

Shklyaev, Sergey; Straube, Arthur V.

2010-01-01

We consider the dynamics of dilute monodisperse bubbly liquid confined by two plane solid walls and subject to small-amplitude high-frequency oscillations normal to the walls. The initial state corresponds to the uniform distribution of bubbles and motionless liquid. The period of external driving is assumed much smaller than typical relaxation times for a single bubble but larger than the period of volume eigenoscillations. The time-averaged description accounting for the two-way coupling between the liquid and the bubbles is applied. We show that the model predicts accumulation of bubbles in thin sheets parallel to the walls. These singular structures, which are formally characterized by infinitely thin width and infinitely high concentration, are referred to as bubbly screens. The formation of a bubbly screen is described analytically in terms of a self-similar solution, which is in agreement with numerical simulations. We study the evolution of bubbly screens and detect a one-dimensional stationary state, which is shown to be unconditionally unstable.

78 FR 75511 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

Science.gov (United States)

2013-12-12

... Inc., Models BD-500-1A10 and BD- 500-1A11 Series Airplanes; Electronic Flight Control System: Control... Inc. Models BD-500-1A10 and BD-500-1A11 series airplanes. These airplanes will have a novel or unusual... comments, data, or views. The most helpful comments reference a specific portion of the special conditions...

77 FR 69568 - Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick...

Science.gov (United States)

2012-11-20

... Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick Controllers AGENCY: Federal Aviation... conditions for the Bombardier Aerospace Model BD-500-1A10 and BD-500-1A11 airplanes. These airplanes will... on the comments we receive. Background On December 10, 2009, Bombardier Aerospace applied for a type...

Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations.

Science.gov (United States)

Bradley, Paul W; Gervasi, Stephanie S; Hua, Jessica; Cothran, Rickey D; Relyea, Rick A; Olson, Deanna H; Blaustein, Andrew R

2015-10-01

Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However, there is little information on whether sensitivity to Bd differs among populations, which is essential for understanding Bd-infection dynamics and for formulating conservation strategies. We experimentally investigated intraspecific differences in host sensitivity to Bd across 10 populations of wood frogs (Lithobates sylvaticus) raised from eggs to metamorphosis. We exposed the post-metamorphic wood frogs to Bd and monitored survival for 30 days under controlled laboratory conditions. Populations differed in overall survival and mortality rate. Infection load also differed among populations but was not correlated with population differences in risk of mortality. Such population-level variation in sensitivity to Bd may result in reservoir populations that may be a source for the transmission of Bd to other sensitive populations or species. Alternatively, remnant populations that are less sensitive to Bd could serve as sources for recolonization after epidemic events. © 2015 Society for Conservation Biology.

Preliminary results on bubble detector as personal neutron dosemeter

International Nuclear Information System (INIS)

Ponraju, D.; Krishnan, H.; Viswanathan, S.; Indira, R.

2011-01-01

The bubble detector is demonstrated as one of the best suitable neutron detectors for neutron dose rate measurements in the presence of high-intense gamma fields. Immobilisation of a volatile liquid in a superheated state and achieving uniform distribution of tiny superheated droplets were a practical challenge. A compact and reusable bubble detector with high neutron sensitivity has been developed at the Indira Gandhi Centre for Atomic Research by immobilising the superheated droplets in a suitable polymer matrix. Two types of bubble detectors have been successfully developed, one by incorporating isobutane for measuring fast neutron and another by incorporating Freon-12 for both fast and thermal neutron. The performance of the detector has been tested using 5 Ci Am-Be neutron source and the results are described. (authors)

Modeling high-energy gamma-rays from the Fermi Bubbles

Energy Technology Data Exchange (ETDEWEB)

Splettstoesser, Megan

2015-09-17

In 2010, the Fermi Bubbles were discovered at the galactic center of the Milky Way. These giant gamma-ray structures, extending 55° in galactic latitude and 20°-30° in galactic longitude, were not predicted. We wish to develop a model for the gamma-ray emission of the Fermi Bubbles. To do so, we assume that second order Fermi acceleration requires charged particles and irregular magnetic fields- both of which are present in the disk of the Milky Way galaxy. By solving the steady-state case of the transport equation, I compute the proton spectrum due to second order Fermi acceleration. I compare the analytical solutions of the proton spectrum to a numerical solution. I find that the numerical solution to the transport equation converges to the analytical solution in all cases. The gamma-ray spectrum due to proton-proton interaction is compared to Fermi Bubble data (from Ackermann et al. 2014), and I find that second order Fermi acceleration is a good fit for the gamma-ray spectrum of the Fermi Bubbles at low energies with an injection source term of S = 1.5 x 10⁻¹⁰ GeV⁻¹cm⁻³yr⁻¹. I find that a non-steady-state solution to the gamma-ray spectrum with an injection source term of S = 2 x 10⁻¹⁰ GeV⁻¹cm⁻³yr⁻¹ matches the bubble data at high energies.

Preparation of bubble damage detectors

International Nuclear Information System (INIS)

Tu Caiqing; Guo Shilun; Wang Yulan; Hao Xiuhong; Chen Changmao; Su Jingling

1997-01-01

Bubble damage detectors have been prepared by using polyacrylamide as detector solid and freon as detector liquid. Tests show that the prepared detectors are sensitive to fast neutrons and have proportionality between bubble number and neutron fluence within a certain range of neutron fluence. Therefore, it can be used as a fast neutron detector and a dosimeter

Simultaneous observation of cavitation bubbles generated in biological tissue by high-speed optical and acoustic imaging methods

Science.gov (United States)

Suzuki, Kai; Iwasaki, Ryosuke; Takagi, Ryo; Yoshizawa, Shin; Umemura, Shin-ichiro

2017-07-01

Acoustic cavitation bubbles are useful for enhancing the heating effect in high-intensity focused ultrasound (HIFU) treatment. Many studies were conducted to investigate the behavior of such bubbles in tissue-mimicking materials, such as a transparent gel phantom; however, the detailed behavior in tissue was still unclear owing to the difficulty in optical observation. In this study, a new biological phantom was developed to observe cavitation bubbles generated in an optically shallow area of tissue. Two imaging methods, high-speed photography using light scattering and high-speed ultrasonic imaging, were used for detecting the behavior of the bubbles simultaneously. The results agreed well with each other for the area of bubble formation and the temporal change in the region of bubbles, suggesting that both methods are useful for visualizing the bubbles.

Continuous ultrasonic waves to detect steam bubbles in water under high pressure

Energy Technology Data Exchange (ETDEWEB)

Hulshof, H J.M.; Schurink, F

1985-01-01

Steam in the recirculation circuit of boilers may lead to unacceptable high thermal loads on the evaporator tubes. The ability to detect steam in the recirculation circuit during process transients is therefore important. A simple detector using continuous ultrasonic waves and able to detect bubbles in water contained in steel tubes is described in this paper. The variation of the transmitted wave caused by the bubbles was determined by demodulation. The results have met the objectives set for cold water with air bubbles. A clear indication of the presence of steam bubbles was found in fast-flowing hot water in a steel tube with a diameter of 60 mm. A change in the low-frequency region of the modulation was the only indication of the presence of steam bubbles in the large-diameter downcomer of the water-separator drum of a boiler in an electrical power plant. Possible causes of the differences in the results obtained are discussed on the basis of differences in bubble sizes and in focusing and reflection of the ultrasonic waves. (orig.). 11 refs.; 10 figs.

Continuous ultrasonic waves to detect steam bubbles in water under high pressure

International Nuclear Information System (INIS)

Hulshof, H.J.M.; Schurink, F.

1985-01-01

Steam in the recirculation circuit of boilers may lead to unacceptable high thermal loads on the evaporator tubes. The ability to detect steam in the recirculation circuit during process transients is therefore important. A simple detector using continuous ultrasonic waves and able to detect bubbles in water contained in steel tubes is described in this paper. The variation of the transmitted wave caused by the bubbles was determined by demodulation. The results have met the objectives set for cold water with air bubbles. A clear indication of the presence of steam bubbles was found in fast-flowing hot water in a steel tube with a diameter of 60 mm. A change in the low-frequency region of the modulation was the only indication of the presence of steam bubbles in the large-diameter downcomer of the water-separator drum of a boiler in an electrical power plant. Possible causes of the differences in the results obtained are discussed on the basis of differences in bubble sizes and in focusing and reflection of the ultrasonic waves. (orig.)

Radiofrequency detection by bubble dosemeter technology

International Nuclear Information System (INIS)

Olsen, R.G.

1990-01-01

In an initial attempt to utilise solid state dosimetric technology for non-ionizing radiation, planar bubble type detectors were irradiated with microwave energy at 2.38 GHz. Individual devices were produced as thin discs (8 cm diam. x 0.6 cm) rather than in the normal test-tube configuration. Both aqueous and non-aqueous-based devices were exposed to plane-wave irradiation inside a microwave anechoic chamber at power densities ranging from 40 to 80 mW.cm -2 . Specific absorption rate (SAR) in the disc shaped devices was thermometrically determined with the aid of a non-perturbing temperature probe and was approximately 0.3 (W.kg -1 )(mW.cm -2 ). Results showed the irradiation-induced bubble response to be relatively uniform in both types of devices, but the sensitivity was lower than that needed in a practical microwave dosemeter. We believe that improved sensitivity will be obtained by adding materials with a high microwave absorption cross section. (author)

Visualisation of gas-liquid mass transfer around a rising bubble in a quiescent liquid using an oxygen sensitive dye

Science.gov (United States)

Dietrich, Nicolas; Hebrard, Gilles

2018-02-01

An approach for visualizing and measuring the mass transfer around a single bubble rising in a quiescent liquid is reported. A colorimetric technique, developed by (Dietrich et al. Chem Eng Sci 100:172-182, 2013) using an oxygen sensitive redox dye was implemented. It was based on the reduction of the colorimetric indicator in presence of oxygen, this reduction being catalysed by sodium hydroxide and glucose. In this study, resazurin was selected because it offered various reduced forms with colours ranging from transparent (without oxygen) to pink (in presence of oxygen). These advantages made it possible to visualize the spatio-temporal oxygen mass transfer around rising bubbles. Images were recorded by a CCD camera and, after post-processing, the shape, size, and velocity of the bubbles were measured and the colours around the bubbles mapped. A calibration, linking the level of colour with the dissolved oxygen concentration, enabled colour maps to be converted into oxygen concentration fields. A rheoscopic fluid was used to visualize the wake of the bubbles. A calculation method was also developed to determine the transferred oxygen fluxes around bubbles of two sizes (d = 0.82 mm and d = 2.12 mm) and the associated liquid-side mass transfer coefficients. The results compared satisfactorily with classical global measurements made by oxygen micro-sensors or from the classical models. This study thus constitutes a striking example of how this new colorimetric method could become a remarkable tool for exploring gas-liquid mass transfer in fluids.

High-density equation of state for helium and its application to bubbles in solids

International Nuclear Information System (INIS)

Wolfer, W.G.

1980-06-01

Helium, produced by transmutations or injected, causes bubble formation in solids at elevated temperatures. For small bubbles, the gas pressure required to balance the surface tension reaches values which far exceed those obtainable in experiments to measure the equation of state for helium gas. Therefore, empirical gas laws cannot be considered applicable to the fluid-like densities existing in small bubbles. In order to remedy this situation, an equation of state for helium was developed from the theory of the liquid state. At very low densities, this theoretically derived equation of state agrees with experimental results. For high densities, however, gas pressures are predicted which are significantly higher than those derived from the ideal gas law, but also significantly lower than pressures obtained with the van der Waals law. When applied to equilibrium bubbles in solids, it is found that the high-density equation of state leads to less bubble swelling than the van der Waals law, but more than the ideal gas law. Furthermore, the number of helium atoms in equilibrium bubbles is nearly independent of temperature

Methane rising from the Deep: Hydrates, Bubbles, Oil Spills, and Global Warming

Science.gov (United States)

Leifer, I.; Rehder, G. J.; Solomon, E. A.; Kastner, M.; Asper, V. L.; Joye, S. B.

2011-12-01

Elevated methane concentrations in near-surface waters and the atmosphere have been reported for seepage from depths of nearly 1 km at the Gulf of Mexico hydrate observatory (MC118), suggesting that for some methane sources, deepsea methane is not trapped and can contribute to atmospheric greenhouse gas budgets. Ebullition is key with important sensitivity to the formation of hydrate skins and oil coatings, high-pressure solubility, bubble size and bubble plume processes. Bubble ROV tracking studies showed survival to near thermocline depths. Studies with a numerical bubble propagation model demonstrated that consideration of structure I hydrate skins transported most methane only to mid-water column depths. Instead, consideration of structure II hydrates, which are stable to far shallower depths and appropriate for natural gas mixtures, allows bubbles to survive to far shallower depths. Moreover, model predictions of vertical methane and alkane profiles and bubble size evolution were in better agreement with observations after consideration of structure II hydrate properties as well as an improved implementation of plume properties, such as currents. These results demonstrate the importance of correctly incorporating bubble hydrate processes in efforts to predict the impact of deepsea seepage as well as to understand the fate of bubble-transported oil and methane from deepsea pipeline leaks and well blowouts. Application to the DWH spill demonstrated the importance of deepsea processes to the fate of spilled subsurface oil. Because several of these parameters vary temporally (bubble flux, currents, temperature), sensitivity studies indicate the importance of real-time monitoring data.

Influenza A (H1N1)pnd09 Vaccination of Pregnant Women and Immunological Consequences for Their Offspring

DEFF Research Database (Denmark)

Bischoff, Anne Louise

2013-01-01

against H1N1pnd09 according to the EMEA criteria with a HI titre of 40 or greater. Women receiving the non-adjuvanted vaccine had significantly fewer local reactions but similar rates of systemic reactions as women receiving the adjuvanted vaccine. There were no reports of serious adverse events in any......Pregnant women experience increased influenza related morbidity and mortality during seasonal influenza epidemics, and even graver outcomes during influenza pandemics. Thus, even though the huge amount of data on clinical efficacy and effectiveness of influenza vaccine in pregnant women......, there is limited information on the details of the immunological responses to influenza immunization in pregnant versus non-pregnant. We had the unique opportunity to study the H1N1pnd09 vaccination of pregnant and non-pregnant women in our unselected, prospective, clinical pregnancy-cohort: the Copenhagen...

Bubble Size Distribution in a Vibrating Bubble Column

Science.gov (United States)

Mohagheghian, Shahrouz; Wilson, Trevor; Valenzuela, Bret; Hinds, Tyler; Moseni, Kevin; Elbing, Brian

2016-11-01

While vibrating bubble columns have increased the mass transfer between phases, a universal scaling law remains elusive. Attempts to predict mass transfer rates in large industrial scale applications by extrapolating laboratory scale models have failed. In a stationary bubble column, mass transfer is a function of phase interfacial area (PIA), while PIA is determined based on the bubble size distribution (BSD). On the other hand, BSD is influenced by the injection characteristics and liquid phase dynamics and properties. Vibration modifies the BSD by impacting the gas and gas-liquid dynamics. This work uses a vibrating cylindrical bubble column to investigate the effect of gas injection and vibration characteristics on the BSD. The bubble column has a 10 cm diameter and was filled with water to a depth of 90 cm above the tip of the orifice tube injector. BSD was measured using high-speed imaging to determine the projected area of individual bubbles, which the nominal bubble diameter was then calculated assuming spherical bubbles. The BSD dependence on the distance from the injector, injector design (1.6 and 0.8 mm ID), air flow rates (0.5 to 5 lit/min), and vibration conditions (stationary and vibration conditions varying amplitude and frequency) will be presented. In addition to mean data, higher order statistics will also be provided.

Development of bubble chambers with enhanced stability and sensitivity to low-energy nuclear recoils

International Nuclear Information System (INIS)

Bolte, W.J.; Collar, J.I.; Crisler, M.; Hall, J.; Holmgren, D.; Nakazawa, D.; Odom, B.; O'Sullivan, K.; Plunkett, R.; Ramberg, E.; Raskin, A.; Sonnenschein, A.; Vieira, J.D.

2007-01-01

The viability of using Bubble Chambers as dark matter particle detectors is considered. Techniques leading to the enhanced chamber stability needed for this new application are described in detail. Prototype trials show that sensitivity to the low-energy nuclear recoils induced by Weakly Interacting Massive Particles (WIMP) is possible in conditions of extreme insensitivity to minimum ionizing backgrounds. An understanding of detector response is demonstrated using existing theoretical models. We briefly comment on the prospects for detection of supersymmetric dark matter with large CF 3 I chambers

High Velocity Spectroscopic Binary Orbits from Photoelectric Radial Velocities: BD+20 5152, a Possible Triple System

Directory of Open Access Journals (Sweden)

Sperauskas J.

2010-12-01

Full Text Available The spectroscopic orbit of a high proper motion star, BD+20 5152, is calculated from 34 CORAVEL-type radial velocity measurements. The star has a slightly eccentric orbit with a period of 5.70613 d, half-amplitude of 47.7 km/s and eccentricity of 0.049. The center-of-mass velocity of the system is -24.3 km/s. BD+20 5152 seems to be a triple system consisting of a G8 dwarf as a primary component and of two K6-M0 dwarfs as secondary and tertiary components. This model is based on the analysis of its UBVRI and JHK magnitudes. According to the SuperWASP photometry, spots on the surface of the primary are suspected. The excessive brightness in the Galex FUV and NUV magnitudes and a non-zero eccentricity suggest the age of this system to be less than 1 Gyr.

Characterization of Phosphate Transporters BdPT4 and BdPT8 in Mycorrhizal and Non-Mychorrhizal Brachypodium distachyon

DEFF Research Database (Denmark)

Clausen, Signe Sandbech

PT proteins were expressed in cells where direct PTs are believed to perform their function, as well as in the vascular tissue. In NM plants, BdPT4 was localized to the plasma membrane whereas BdPT8 accumulated in the endoplasmic reticulum (ER) in the secretory pathway. A similar expression pattern...... was observed in non-arbusculated cells of AM plants. In arbusculated cells, BdPT8 was detected in the ER while BdPT4 was localized to the plasma membrane and the periarbuscular membrane (PAM) surrounding the arbuscular trunk and thick branches, which further supported a role of both BdPTs in direct Pi uptake......Phosphorus (P) is an essential plant nutrient in agricultural production but the P rock reserves used for production of fertilizers are currently being depleted. One approach to reduce the demand on P fertilizers is to optimize the phosphate (Pi) uptake and utilization efficiency of crop plants...

How are soap bubbles blown? Fluid dynamics of soap bubble blowing

Science.gov (United States)

Davidson, John; Lambert, Lori; Sherman, Erica; Wei, Timothy; Ryu, Sangjin

2013-11-01

Soap bubbles are a common interfacial fluid dynamics phenomenon having a long history of delighting not only children and artists but also scientists. In contrast to the dynamics of liquid droplets in gas and gas bubbles in liquid, the dynamics of soap bubbles has not been well documented. This is possibly because studying soap bubbles is more challenging due to there existing two gas-liquid interfaces. Having the thin-film interface seems to alter the characteristics of the bubble/drop creation process since the interface has limiting factors such as thickness. Thus, the main objective of this study is to determine how the thin-film interface differentiates soap bubbles from gas bubbles and liquid drops. To investigate the creation process of soap bubbles, we constructed an experimental model consisting of air jet flow and a soap film, which consistently replicates the conditions that a human produces when blowing soap bubbles, and examined the interaction between the jet and the soap film using the high-speed videography and the particle image velocimetry.

Computed tomographic angiography criteria in the diagnosis of brain death - comparison of sensitivity and interobserver reliability of different evaluation scales

Energy Technology Data Exchange (ETDEWEB)

Sawicki, Marcin; Walecka, A. [Pomeranian Medical University, Department of Diagnostic Imaging and Interventional Radiology, Szczecin (Poland); Bohatyrewicz, R.; Solek-Pastuszka, J. [Pomeranian Medical University, Clinic of Anesthesiology and Intensive Care, Szczecin (Poland); Safranow, K. [Pomeranian Medical University, Department of Biochemistry and Medical Chemistry, Szczecin (Poland); Walecki, J. [The Centre of Postgraduate Medical Education, Warsaw (Poland); Rowinski, O. [Medical University of Warsaw, 2nd Department of Clinical Radiology, Warsaw (Poland); Czajkowski, Z. [Regional Joint Hospital, Szczecin (Poland); Guzinski, M. [Wroclaw Medical University, Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw (Poland); Burzynska, M. [Wroclaw Medical University, Department of Anesthesiology and Intensive Therapy, Wroclaw (Poland); Wojczal, J. [Medical University of Lublin, Department of Neurology, Lublin (Poland)

2014-08-15

The standardized diagnostic criteria for computed tomographic angiography (CTA) in diagnosis of brain death (BD) are not yet established. The aim of the study was to compare the sensitivity and interobserver agreement of the three previously used scales of CTA for the diagnosis of BD. Eighty-two clinically brain-dead patients underwent CTA with a delay of 40 s after contrast injection. Catheter angiography was used as the reference standard. CTA results were assessed by two radiologists, and the diagnosis of BD was established according to 10-, 7-, and 4-point scales. Catheter angiography confirmed the diagnosis of BD in all cases. Opacification of certain cerebral vessels as indicator of BD was highly sensitive: cortical segments of the middle cerebral artery (96.3 %), the internal cerebral vein (98.8 %), and the great cerebral vein (98.8 %). Other vessels were less sensitive: the pericallosal artery (74.4 %), cortical segments of the posterior cerebral artery (79.3 %), and the basilar artery (82.9 %). The sensitivities of the 10-, 7-, and 4-point scales were 67.1, 74.4, and 96.3 %, respectively (p < 0.001). Percentage interobserver agreement in diagnosis of BD reached 93 % for the 10-point scale, 89 % for the 7-point scale, and 95 % for the 4-point scale (p = 0.37). In the application of CTA to the diagnosis of BD, reducing the assessment of vascular opacification scale from a 10- to a 4-point scale significantly increases the sensitivity and maintains high interobserver reliability. (orig.)

Computed tomographic angiography criteria in the diagnosis of brain death - comparison of sensitivity and interobserver reliability of different evaluation scales

International Nuclear Information System (INIS)

Sawicki, Marcin; Walecka, A.; Bohatyrewicz, R.; Solek-Pastuszka, J.; Safranow, K.; Walecki, J.; Rowinski, O.; Czajkowski, Z.; Guzinski, M.; Burzynska, M.; Wojczal, J.

2014-01-01

The standardized diagnostic criteria for computed tomographic angiography (CTA) in diagnosis of brain death (BD) are not yet established. The aim of the study was to compare the sensitivity and interobserver agreement of the three previously used scales of CTA for the diagnosis of BD. Eighty-two clinically brain-dead patients underwent CTA with a delay of 40 s after contrast injection. Catheter angiography was used as the reference standard. CTA results were assessed by two radiologists, and the diagnosis of BD was established according to 10-, 7-, and 4-point scales. Catheter angiography confirmed the diagnosis of BD in all cases. Opacification of certain cerebral vessels as indicator of BD was highly sensitive: cortical segments of the middle cerebral artery (96.3 %), the internal cerebral vein (98.8 %), and the great cerebral vein (98.8 %). Other vessels were less sensitive: the pericallosal artery (74.4 %), cortical segments of the posterior cerebral artery (79.3 %), and the basilar artery (82.9 %). The sensitivities of the 10-, 7-, and 4-point scales were 67.1, 74.4, and 96.3 %, respectively (p < 0.001). Percentage interobserver agreement in diagnosis of BD reached 93 % for the 10-point scale, 89 % for the 7-point scale, and 95 % for the 4-point scale (p = 0.37). In the application of CTA to the diagnosis of BD, reducing the assessment of vascular opacification scale from a 10- to a 4-point scale significantly increases the sensitivity and maintains high interobserver reliability. (orig.)

HIGH SPATIAL RESOLUTION IMAGING OF INERTIAL FUSION TARGET PLASMAS USING BUBBLE NEUTRON DETECTORS

International Nuclear Information System (INIS)

FISHER, R.K.

2003-01-01

OAK B202 HIGH SPATIAL RESOLUTION IMAGING OF INERTIAL FUSION TARGET PLASMAS USING BUBBLE NEUTRON DETECTORS. Bubble detectors, which can detect neutrons with a spatial 5 to 30 (micro), are the most promising approach to imaging NIF target plasmas with the desired 5 (micro) spatial resolution in the target plane. Gel bubble detectors are being tested to record neutron images of ICF implosions in OMEGA experiments. By improving the noise reduction techniques used in analyzing the data taken in June 2000, we have been able to image the neutron emission from 6 · 10 13 yield DT target plasmas with a target plane spatial resolution of ∼ 140 (micro). As expected, the spatial resolution was limited by counting statistics as a result of the low neutron detection efficiency of the easy-to-use gel bubble detectors. The results have been submitted for publication and will be the subject of an invited talk at the October 2001 Meeting of the Division of Plasma Physics of the American Physical Society. To improve the counting statistics, data was taken in May 2001 using a stack of four gel detectors and integrated over a series of up to seven high-yield DT shots. Analysis of the 2001 data is still in its early stages. Gel detectors were chosen for these initial tests since the bubbles can be photographed several hours after the neutron exposure. They consist of ∼ 5000 drops (∼ 100 (micro) in diameter) of bubble detector liquid/cm 3 suspended in an inactive support gel that occupies ∼ 99% of the detector volume. Using a liquid bubble chamber detector and a light scattering system to record the bubble locations a few microseconds after the neutron exposure when the bubbles are ∼ 10 (micro) in diameter, should result in ∼ 1000 times higher neutron detection efficiency and a target plane resolution on OMEGA of ∼ 10 to 50 (micro)

Automated high-speed video analysis of the bubble dynamics in subcooled flow boiling

Energy Technology Data Exchange (ETDEWEB)

Maurus, Reinhold; Ilchenko, Volodymyr; Sattelmayer, Thomas [Technische Univ. Muenchen, Lehrstuhl fuer Thermodynamik, Garching (Germany)

2004-04-01

Subcooled flow boiling is a commonly applied technique for achieving efficient heat transfer. In the study, an experimental investigation in the nucleate boiling regime was performed for water circulating in a closed loop at atmospheric pressure. The test-section consists of a rectangular channel with a one side heated copper strip and a very good optical access. For the optical observation of the bubble behaviour the high-speed cinematography is used. Automated image processing and analysis algorithms developed by the authors were applied for a wide range of mass flow rates and heat fluxes in order to extract characteristic length and time scales of the bubbly layer during the boiling process. Using this methodology, a huge number of bubble cycles could be analysed. The structure of the developed algorithms for the detection of the bubble diameter, the bubble lifetime, the lifetime after the detachment process and the waiting time between two bubble cycles is described. Subsequently, the results from using these automated procedures are presented. A remarkable novelty is the presentation of all results as distribution functions. This is of physical importance because the commonly applied spatial and temporal averaging leads to a loss of information and, moreover, to an unjustified deterministic view of the boiling process, which exhibits in reality a very wide spread of bubble sizes and characteristic times. The results show that the mass flux dominates the temporal bubble behaviour. An increase of the liquid mass flux reveals a strong decrease of the bubble life - and waiting time. In contrast, the variation of the heat flux has a much smaller impact. It is shown in addition that the investigation of the bubble history using automated algorithms delivers novel information with respect to the bubble lift-off probability. (Author)

Automated high-speed video analysis of the bubble dynamics in subcooled flow boiling

International Nuclear Information System (INIS)

Maurus, Reinhold; Ilchenko, Volodymyr; Sattelmayer, Thomas

2004-01-01

Subcooled flow boiling is a commonly applied technique for achieving efficient heat transfer. In the study, an experimental investigation in the nucleate boiling regime was performed for water circulating in a closed loop at atmospheric pressure. The test-section consists of a rectangular channel with a one side heated copper strip and a very good optical access. For the optical observation of the bubble behaviour the high-speed cinematography is used. Automated image processing and analysis algorithms developed by the authors were applied for a wide range of mass flow rates and heat fluxes in order to extract characteristic length and time scales of the bubbly layer during the boiling process. Using this methodology, a huge number of bubble cycles could be analysed. The structure of the developed algorithms for the detection of the bubble diameter, the bubble lifetime, the lifetime after the detachment process and the waiting time between two bubble cycles is described. Subsequently, the results from using these automated procedures are presented. A remarkable novelty is the presentation of all results as distribution functions. This is of physical importance because the commonly applied spatial and temporal averaging leads to a loss of information and, moreover, to an unjustified deterministic view of the boiling process, which exhibits in reality a very wide spread of bubble sizes and characteristic times. The results show that the mass flux dominates the temporal bubble behaviour. An increase of the liquid mass flux reveals a strong decrease of the bubble life- and waiting time. In contrast, the variation of the heat flux has a much smaller impact. It is shown in addition that the investigation of the bubble history using automated algorithms delivers novel information with respect to the bubble lift-off probability

Helium solubility and bubble growth in metals under high pressure

International Nuclear Information System (INIS)

Laakmann, J.

1985-07-01

Helium solubility and bubble growth in metals under high pressure polycrystals and single crystals of gold were heated in helium at temperatures between 475 K and 1250 K in a pressure regime of 200 to 2700 bar to measure the solubility of helium in gold. After quenching to room temperature the helium content, measured by mass spectrometry, showed the following properties: 1) A linear dependence of the He solubility on pressure. 2) Thinning of the specimen reduces the helium content by a factor 10 to 100 but does not change the linear pressure dependence. 3) The thermal release of He from thinned polycrystals and single crystals occurs mainly in a single peak at 500 K. 4) The He concentration of the thinned single crystals was lower by a factor of 10 to 50 than that of the thinned polycrystals. 5) The He solubility in single crystals can be described by an enthalpy of solution Hsub(s)sup(f) = 0.85 +- 0.7 eV and a non-configurational entropy of Ssub(s)sup(f) between 0 k and 1 k (k: Boltzmann-constant). In order to measure the pressure dependence of helium bubble growth in nickel polycrystal Ni-foils were α-implanted to a helium content of 130 appm. The evaluation of the size distribution of the helium bubbles after heat treatments shows 1) The helium content of the observable bubbles - assumed to be in equilibrium - equals the amount of helium implanted into the specimen. 2) The activation energy for the growth of helium bubbles is 1.25 +- 0.3 eV. The comparison of specimen which had been heated at low pressures up to 10 bar with others heated at 2500-2700 bar does not show an unequivocal pressure dependence for helium bubble growth. (orig./IHOE) [de

High-performance colorimeter with an electronic bubble gate for use in miniaturized continuous-flow analyzers.

Science.gov (United States)

Neeley, W E; Wardlaw, S C; Yates, T; Hollingsworth, W G; Swinnen, M E

1976-02-01

We describe a high-performance colorimeter with an electronic bubble gate for use with miniaturized continuous-flow analyzers. The colorimeter has a flow-through cuvette with optically flat quartz windows that allows a bubbled stream to pass freely without any breakup or retention of bubbles. The fluid volume in the light path is only 1.8 mul. The electronic bubble gate selectively removes that portion of the photodector signal produced by the air bubbles passing through the flow cell and allows that portion of the signal attributable to the fluid segment to pass to the recorder. The colorimeter is easy to use, rugged, inexpensive, and requires minimal adjustments.

High efficiency hydrodynamic DNA fragmentation in a bubbling system

NARCIS (Netherlands)

Li, Lanhui; Jin, Mingliang; Sun, Chenglong; Wang, Xiaoxue; Xie, Shuting; Zhou, Guofu; Van Den Berg, Albert; Eijkel, Jan C.T.; Shui, Lingling

2017-01-01

DNA fragmentation down to a precise fragment size is important for biomedical applications, disease determination, gene therapy and shotgun sequencing. In this work, a cheap, easy to operate and high efficiency DNA fragmentation method is demonstrated based on hydrodynamic shearing in a bubbling

Expendable bubble tiltmeter for geophysical monitoring

OpenAIRE

Westphal, J. A.; Carr, M. A.; Miller, W. F.; Dzurisin, Daniel

1983-01-01

An unusually rugged highly sensitive and inexpensive bubble tiltmeter has been designed, tested, and built in quantity. These tiltmeters are presently used on two volcanoes and an Alaskan glacier, where they continuously monitor surface tilts of geological interest. This paper discusses the mechanical, thermal, and electric details of the meter, and illustrates its performance characteristics in both large ( > 10^(-4) radian) and small ( < 10^(-6) radian) tilt environments. The meter's ult...

Bubble nucleation dynamics in 3He/4He mixture by holographic interferometry

International Nuclear Information System (INIS)

Morikawa, M; Abe, H; Nomura, R; Okuda, Y

2009-01-01

We were able to nucleate a gas bubble in the diluted phase of 3 He- 4 He mixture by a 1 ms width strong sound pulse. The nucleated bubble became large and detached from the bottom transducer and was pushed out to the bulk liquid by the acoustic wave pulse. The bubble then repeatedly expanded and contracted a few times and finally disappeared. The overall motion of the bubble was traced by a high speed camera with a time resolution of 1 ms. We are attempting to investigate the small density fluctuation around the bubble by incorporating holographic interferometry technology. The measurement was done at T=0.35 K for the phase separated mixture at saturated vapor pressure. An acoustic wave transducer was located at the bottom of the cell, so the bubble was nucleated in the dilute phase of the mixture. We resolved the density fluctuation as small as Δρ/ρ = 2 x 10 -6 in the dilute phase with the sample width of 25 mm, which could not be obtained by other methods. It was found that there appeared a less dense region of -Δρ/ρ ∼ 1.46 x 10 -3 just above the bubble. The bubble appeared just after the pulse was turned off, but this less dense region appeared prior to the emergence of the bulk bubble. It should be an important information about the bubble nucleation mechanism. This very high sensitivity of holographic interferometry with respect to the density fluctuation could be widely used in quantum liquid.

Nonlinear Bubble Dynamics And The Effects On Propagation Through Near-Surface Bubble Layers

Science.gov (United States)

Leighton, Timothy G.

2004-11-01

Nonlinear bubble dynamics are often viewed as the unfortunate consequence of having to use high acoustic pressure amplitudes when the void fraction in the near-surface oceanic bubble layer is great enough to cause severe attenuation (e.g. >50 dB/m). This is seen as unfortunate since existing models for acoustic propagation in bubbly liquids are based on linear bubble dynamics. However, the development of nonlinear models does more than just allow quantification of the errors associated with the use of linear models. It also offers the possibility of propagation modeling and acoustic inversions which appropriately incorporate the bubble nonlinearity. Furthermore, it allows exploration and quantification of possible nonlinear effects which may be exploited. As a result, high acoustic pressure amplitudes may be desirable even in low void fractions, because they offer opportunities to gain information about the bubble cloud from the nonlinearities, and options to exploit the nonlinearities to enhance communication and sonar in bubbly waters. This paper presents a method for calculating the nonlinear acoustic cross-sections, scatter, attenuations and sound speeds from bubble clouds which may be inhomogeneous. The method allows prediction of the time dependency of these quantities, both because the cloud may vary and because the incident acoustic pulse may have finite and arbitrary time history. The method can be readily adapted for bubbles in other environments (e.g. clouds of interacting bubbles, sediments, structures, in vivo, reverberant conditions etc.). The possible exploitation of bubble acoustics by marine mammals, and for sonar enhancement, is explored.

Bubble parameters analysis of gas-liquid two-phase sparse bubbly flow based on image method

International Nuclear Information System (INIS)

Zhou Yunlong; Zhou Hongjuan; Song Lianzhuang; Liu Qian

2012-01-01

The sparse rising bubbles of gas-liquid two-phase flow in vertical pipe were measured and studied based on image method. The bubble images were acquired by high-speed video camera systems, the characteristic parameters of bubbles were extracted by using image processing techniques. Then velocity variation of rising bubbles were drawn. Area and centroid variation of single bubble were also drawn. And then parameters and movement law of bubbles were analyzed and studied. The test results showed that parameters of bubbles had been analyzed well by using image method. (authors)

Dynamics of diffusive bubble growth and pressure recovery in a bubbly rhyolitic melt embedded in an elastic solid

Science.gov (United States)

Chouet, Bernard A.; Dawson, Phillip B.; Nakano, Masaru

2006-01-01

We present a model of gas exsolution and bubble expansion in a melt supersaturated in response to a sudden pressure drop. In our model, the melt contains a suspension of gas bubbles of identical sizes and is encased in a penny-shaped crack embedded in an elastic solid. The suspension is modeled as a three-dimensional lattice of spherical cells with slight overlap, where each elementary cell consists of a gas bubble surrounded by a shell of volatile-rich melt. The melt is then subjected to a step drop in pressure, which induces gas exsolution and bubble expansion, resulting in the compression of the melt and volumetric expansion of the crack. The dynamics of diffusion-driven bubble growth and volumetric crack expansion span 9 decades in time. The model demonstrates that the speed of the crack response depends strongly on volatile diffusivity in the melt and bubble number density and is markedly sensitive to the ratio of crack thickness to crack radius and initial bubble radius but is relatively insensitive to melt viscosity. The net drop in gas concentration in the melt after pressure recovery represents only a small fraction of the initial concentration prior to the drop, suggesting the melt may undergo numerous pressure transients before becoming significantly depleted of gases. The magnitude of pressure and volume recovery in the crack depends sensitively on the size of the input-pressure transient, becoming relatively larger for smaller-size transients in a melt containing bubbles with initial radii less than 10-5 m. Amplification of the input transient may be large enough to disrupt the crack wall and induce brittle failure in the rock matrix surrounding the crack. Our results provide additional basis for the interpretation of volume changes in the magma conduit under Popocatépetl Volcano during Vulcanian degassing bursts in its eruptive activity in April–May 2000.

Particle-bubble aggregate stability on static bubble generated by single nozzle on flotation process

Science.gov (United States)

Warjito, Harinaldi, Setyantono, Manus; Siregar, Sahala D.

2016-06-01

There are three sub-processes on flotation. These processes are intervening liquid film into critical thickness, rupture of liquid film forming three phase contact line, and expansion three phase contact line forming aggregate stability. Aggregate stability factor contribute to determine flotation efficiency. Aggregate stability has some important factors such as reagent and particle geometry. This research focussed on to understand effect of particle geometry to aggregate stability. Experimental setup consists of 9 x 9 x26 cm flotation column made of glass, bubble generator, particle feeding system, and high speed video camera. Bubble generator made from single nozzle with 0.3 mm diameter attached to programmable syringe pump. Particle feeding system made of pipette. Particle used in this research is taken from open pit Grasberg in Timika, Papua. Particle has sub-angular geometry and its size varies from 38 to 300 µm. Bubble-particle interaction are recorded using high speed video camera. Recordings from high speed video camera analyzed using image processing software. Experiment result shows that aggregate particle-bubble and induction time depends on particle size. Small particle (38-106 µm) has long induction time and able to rupture liquid film and also forming three phase contact line. Big particle (150-300 µm) has short induction time, so it unable to attach with bubble easily. This phenomenon is caused by apparent gravity work on particle-bubble interaction. Apparent gravity worked during particle sliding on bubble surface experience increase and reached its maximum magnitude at bubble equator. After particle passed bubble equator, apparent gravity force experience decrease. In conclusion particle size from 38-300 µm can form stable aggregate if particle attached with bubble in certain condition.

Anonimi, “Ges al meu grat non sui joglar” (BdT 461.126, “Per zo no·m voil desconortar” (BdT 461.193, “Va, cobla: al Juge de Galur” (BdT 461.246, “Seigner Juge, ben aug dir a la gen” (BdT 461.217, “Ges per li diz non er bons prez sabuz” (BdT 461.133

Directory of Open Access Journals (Sweden)

Giuseppe Noto

2012-09-01

Full Text Available My paper provides a new critical edition, with critical apparatus, comment and translation of a set of anonymous ‘coblas’, copied as a sequence in the anthology present at ff. 55-66 in chansonnier P: BdT 461.126; BdT 461.193; BdT 461.246; BdT 461.217; BdT 461.133 (all of which are unica. I will examine in particular the attributions suggested so far for one or more of these ‘coblas’ (a name that has frequently been put forward is that of Paolo Lanfranchi da Pistoia, author of the sonnet in ‘cobla’ form copied in P immediately preceding the poems discussed here and address the hypothesis put forward by several scholars (and upheld with convincing evidence by Stefano Asperti that the sequence under consideration points to the strong presence of a Tuscan tradition in chansonnier P, clearly contributing, among other things, to outline a “fundamental coherence” (Asperti between some aspects of Dante’s literary culture and this particular songbook.

A reduced-order, single-bubble cavitation model with applications to therapeutic ultrasound.

Science.gov (United States)

Kreider, Wayne; Crum, Lawrence A; Bailey, Michael R; Sapozhnikov, Oleg A

2011-11-01

Cavitation often occurs in therapeutic applications of medical ultrasound such as shock-wave lithotripsy (SWL) and high-intensity focused ultrasound (HIFU). Because cavitation bubbles can affect an intended treatment, it is important to understand the dynamics of bubbles in this context. The relevant context includes very high acoustic pressures and frequencies as well as elevated temperatures. Relative to much of the prior research on cavitation and bubble dynamics, such conditions are unique. To address the relevant physics, a reduced-order model of a single, spherical bubble is proposed that incorporates phase change at the liquid-gas interface as well as heat and mass transport in both phases. Based on the energy lost during the inertial collapse and rebound of a millimeter-sized bubble, experimental observations were used to tune and test model predictions. In addition, benchmarks from the published literature were used to assess various aspects of model performance. Benchmark comparisons demonstrate that the model captures the basic physics of phase change and diffusive transport, while it is quantitatively sensitive to specific model assumptions and implementation details. Given its performance and numerical stability, the model can be used to explore bubble behaviors across a broad parameter space relevant to therapeutic ultrasound.

Expression of beta-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: lack of upregulation in vivo upon Salmonella typhimurium infection.

Science.gov (United States)

Veldhuizen, Edwin J A; van Dijk, Albert; Tersteeg, Monique H G; Kalkhove, Stefanie I C; van der Meulen, Jan; Niewold, Theo A; Haagsman, Henk P

2007-01-01

Defensins are antimicrobial peptides that play an important role in the innate immune response in the intestine. Up to date, only one beta-defensin (pBD-1), has been described in pig, which was found to be expressed at low levels in the intestine. We set-up a quantitative PCR method to detect the gene expression of pBD-1 and a newly discovered porcine beta-defensin, pBD-2. Expression of pBD-1 mRNA increased from the proximal to the distal part of the intestine whereas pBD-2 expression decreased. The main gene expression sites for pBD-2 were kidney and liver, whereas pBD-1 was mainly expressed in tongue. The porcine small intestinal segment perfusion (SISP) technique was used to investigate effects of Salmonella typhimurium DT104 on intestinal morphology and pBD-1 and pBD-2 mRNA levels in vivo. The early responses were studied 2, 4 and 8 h post-infection in four separate jejunal and ileal segments. Immunohistochemistry showed invasion of the mucosa by Salmonella and changes in intestinal morphology. However, no concomitant changes in expression of either pBD-1 or pBD-2 were observed. We conclude that at least two defensins are differentially expressed in the intestine of pigs, and that expression of both defensins is not altered by S. typhimurium under these conditions.

Improvement in the amine glass platform by bubbling method for a DNA microarray.

Science.gov (United States)

Jee, Seung Hyun; Kim, Jong Won; Lee, Ji Hyeong; Yoon, Young Soo

2015-01-01

A glass platform with high sensitivity for sexually transmitted diseases microarray is described here. An amino-silane-based self-assembled monolayer was coated on the surface of a glass platform using a novel bubbling method. The optimized surface of the glass platform had highly uniform surface modifications using this method, as well as improved hybridization properties with capture probes in the DNA microarray. On the basis of these results, the improved glass platform serves as a highly reliable and optimal material for the DNA microarray. Moreover, in this study, we demonstrated that our glass platform, manufactured by utilizing the bubbling method, had higher uniformity, shorter processing time, lower background signal, and higher spot signal than the platforms manufactured by the general dipping method. The DNA microarray manufactured with a glass platform prepared using bubbling method can be used as a clinical diagnostic tool.

A Molecular dynamics study of helium bubble stability during high-energy displacement cascades in alpha-iron

International Nuclear Information System (INIS)

Pu, Jin; Yang, Li; Zu, Xiaotao; Gao, Fei

2007-01-01

The interactions of high-energy displacement cascades with helium bubbles in a-Fe are investigated using molecular dynamics simulations. Initial bubbles with the volumes of 212 and 636 (angstrom)3 are considered, and the helium-to-vacancy (He/V) ratio in the bubbles varies from 0.5 to 3. Primary knock-on atom (PKA) energy, Ep, is up to 40 keV. The results show that the change of nm-sized He bubbles due to displacement cascade does not depend much on the bubble size, but rather on the He/V ratio and the recoil energy. For the initial He/V ratio less than 1, the size of the bubbles decreases with increasing PKA energy, but the He/V ratio increases. However, for the initial He/V ratio of 3, the size of the bubbles increases, and the He/V ratio decreases with PKA energy. For the initial He/V ratio of 1, the ratio of the small bubble decreases slightly, but the ratio of the large bubble remains unchanged for lower PKA energy, and increases slightly for higher PKA energy. The reasons for these observed phenomena have been explained

Trajectory and physical properties of near-Earth asteroid 2009 BD

NARCIS (Netherlands)

Farnocchia, D.; Mommert, M.; Hora, J. L.; Chesley, S. R.; Vokrouhlický, D.; Trilling, D. E.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.; Knežević, Zoran; Lemaitre, Anne

2014-01-01

We analyze the trajectory of near-Earth asteroid 2009~BD, which is a candidate target of the NASA Asteroid Redirect Mission. The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational perturbations, such as

Theory calculation of combination of 'embryo' bubble growing-up visible bubble in bubble chamber

International Nuclear Information System (INIS)

Ye Zipiao; Sheng Xiangdong; Dai Changjiang

2004-01-01

By aid of island combination theory of 'embryo' bubble, it is resolved well the question which 'embryo' bubble grows up a visible bubble in the bubble chamber. Through theory calculation it is shown that radius of the big' embryo' bubble combinated not only relates with work matter such as surface tension coefficient, saturation vapour pressure and boiling point of liquid, but also does absorbing quantity of heat and the numbers of 'embryo' bubbles combination. It is explained reasonably that the radius of bubbles in bubble chamber is different for the same energies of neutrons and proton. The track of neutron in bubble chamber is long and thin, and the track of proton in bubble chamber is wide and short. It is also explained reasonably that the bubble radius of the incident particles with more charges which there are the same energies will be wider than that of the incident particles with less charges in the track. (author)

Expendable bubble tiltmeter for geophysical monitoring

Science.gov (United States)

Westphal, J.A.; Carr, M.A.; Miller, W.F.; Dzurisin, D.

1983-01-01

An unusually rugged highly sensitive and inexpensive bubble tiltmeter has been designed, tested, and built in quantity. These tiltmeters are presently used on two volcanoes and an Alaskan glacier, where they continuously monitor surface tilts of geological interest. This paper discusses the mechanical, thermal, and electric details of the meter, and illustrates its performance characteristics in both large (>10-4 radian) and small (<10-6 radian) tilt environments. The meter's ultimate sensitivity is better than 2??10-8 radians rms for short periods (hours), and its useful dynamic range is greater than 10 4. Included is a short description of field use of the instrument for volcano monitoring.

Bubble size distribution analysis and control in high frequency ultrasonic cleaning processes

International Nuclear Information System (INIS)

Hauptmann, M; Struyf, H; Mertens, P; Heyns, M; Gendt, S De; Brems, S; Glorieux, C

2012-01-01

In the semiconductor industry, the ongoing down-scaling of nanoelectronic elements has lead to an increasing complexity of their fabrication. Hence, the individual fabrication processes become increasingly difficult to handle. To minimize cross-contamination, intermediate surface cleaning and preparation steps are inevitable parts of the semiconductor process chain. Here, one major challenge is the removal of residual nano-particulate contamination resulting from abrasive processes such as polishing and etching. In the past, physical cleaning techniques such as megasonic cleaning have been proposed as suitable solutions. However, the soaring fragility of the smallest structures is constraining the forces of the involved physical removal mechanisms. In the case of 'megasonic' cleaning –cleaning with ultrasound in the MHz-domain – the main cleaning action arises from strongly oscillating microbubbles which emerge from the periodically changing tensile strain in the cleaning liquid during sonication. These bubbles grow, oscillate and collapse due to a complex interplay of rectified diffusion, bubble coalescence, non-linear pulsation and the onset of shape instabilities. Hence, the resulting bubble size distribution does not remain static but alternates continuously. Only microbubbles in this distribution that show a high oscillatory response are responsible for the cleaning action. Therefore, the cleaning process efficiency can be improved by keeping the majority of bubbles around their resonance size. In this paper, we propose a method to control and characterize the bubble size distribution by means of 'pulsed' sonication and measurements of acoustic cavitation spectra, respectively. We show that the so-obtained bubble size distributions can be related to theoretical predictions of the oscillatory responses of and the onset of shape instabilities for the respective bubbles. We also propose a mechanism to explain the enhancement of both acoustic and cleaning

High Efficiency Dye-sensitized Solar Cells Constructed with Composites of TiO2 and the Hot-bubbling Synthesized Ultra-Small SnO2 Nanocrystals.

Science.gov (United States)

Mao, Xiaoli; Zhou, Ru; Zhang, Shouwei; Ding, Liping; Wan, Lei; Qin, Shengxian; Chen, Zhesheng; Xu, Jinzhang; Miao, Shiding

2016-01-13

An efficient photo-anode for the dye-sensitized solar cells (DSSCs) should have features of high loading of dye molecules, favorable band alignments and good efficiency in electron transport. Herein, the 3.4 nm-sized SnO2 nanocrystals (NCs) of high crystallinity, synthesized via the hot-bubbling method, were incorporated with the commercial TiO2 (P25) particles to fabricate the photo-anodes. The optimal percentage of the doped SnO2 NCs was found at ~7.5% (SnO2/TiO2, w/w), and the fabricated DSSC delivers a power conversion efficiency up to 6.7%, which is 1.52 times of the P25 based DSSCs. The ultra-small SnO2 NCs offer three benefits, (1) the incorporation of SnO2 NCs enlarges surface areas of the photo-anode films, and higher dye-loading amounts were achieved; (2) the high charge mobility provided by SnO2 was confirmed to accelerate the electron transport, and the photo-electron recombination was suppressed by the highly-crystallized NCs; (3) the conduction band minimum (CBM) of the SnO2 NCs was uplifted due to the quantum size effects, and this was found to alleviate the decrement in the open-circuit voltage. This work highlights great contributions of the SnO2 NCs to the improvement of the photovoltaic performances in the DSSCs.

Acoustic bubble sorting for ultrasound contrast agent enrichment.

Science.gov (United States)

Segers, Tim; Versluis, Michel

2014-05-21

An ultrasound contrast agent (UCA) suspension contains encapsulated microbubbles with a wide size distribution, with radii ranging from 1 to 10 μm. Medical transducers typically operate at a single frequency, therefore only a small selection of bubbles will resonate to the driving ultrasound pulse. Thus, the sensitivity can be improved by narrowing down the size distribution. Here, we present a simple lab-on-a-chip method to sort the population of microbubbles on-chip using a traveling ultrasound wave. First, we explore the physical parameter space of acoustic bubble sorting using well-defined bubble sizes formed in a flow-focusing device, then we demonstrate successful acoustic sorting of a commercial UCA. This novel sorting strategy may lead to an overall improvement of the sensitivity of contrast ultrasound by more than 10 dB.

Visualization of airflow growing soap bubbles

Science.gov (United States)

Al Rahbi, Hamood; Bock, Matthew; Ryu, Sangjin

2016-11-01

Visualizing airflow inside growing soap bubbles can answer questions regarding the fluid dynamics of soap bubble blowing, which is a model system for flows with a gas-liquid-gas interface. Also, understanding the soap bubble blowing process is practical because it can contribute to controlling industrial processes similar to soap bubble blowing. In this study, we visualized airflow which grows soap bubbles using the smoke wire technique to understand how airflow blows soap bubbles. The soap bubble blower setup was built to mimic the human blowing process of soap bubbles, which consists of a blower, a nozzle and a bubble ring. The smoke wire was placed between the nozzle and the bubble ring, and smoke-visualized airflow was captured using a high speed camera. Our visualization shows how air jet flows into the growing soap bubble on the ring and how the airflow interacts with the soap film of growing bubble.

The Prevalence of Tobacco, Hubble-Bubble, Alcoholic Drinks, Drugs, and Stimulants among High-School Students

Directory of Open Access Journals (Sweden)

Roghayeh Alaee

2011-08-01

Full Text Available Introduction: The purpose of the present study was to investigate the prevalence of tobacco, hubble-bubble, alcoholic drinks, and other drugs among Karaj high-school students in 2011. Methods: The research method was a descriptive-sectional study. Participants of this study were 447 girl and boy high-school students of Karaj that were selected by clustering random sampling. For data gathering, drug abuse questionnaire, and risk and protective factors inventory were administered among selected sample. Results: According to the results, 57% of students in this study said that they have had experiences with a kind of drug including tobacco, hubble-bubble, alcoholic drinks, and other drugs at least once in their lives. The study showed the prevalence for soft drugs: hubble-bubble, tobacco, and alcoholic drinks, and for hard drugs ecstasy, opium, hashish, meth, crack, and heroin respectively. Conclusion: Soft drugs including hubble-bubble, tobacco, and alcoholic drinks, are the most common among Karaj high-school students. The prevalence of hard drugs among them is rather low.

Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine.

Science.gov (United States)

Arenas, M Carmen; Daza-Losada, Manuel; Vidal-Infer, Antonio; Aguilar, Maria A; Miñarro, José; Rodríguez-Arias, Marta

2014-06-22

Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is considered to predict the response of animals to drugs of abuse and, thus, allow "drug-vulnerable" individuals to be identified. The main objective of this study was to assess the predictive ability of two well-known paradigms of the novelty-seeking trait - novelty-induced locomotor activity (which distinguishes High- and Low-Responder mice, depending on their motor activity) and the hole-board test (which determines High- and Low-Novelty Seeker mice depending on the number of head dips they perform) - to identify subjects that would subsequently be more sensitive to the conditioned rewarding effects of cocaine in a population of young adult (PND 56) and adolescent (PND 35) OF1 mice of both sexes. Conditioned place preference (CPP), a useful tool for evaluating the sensitivity of individuals to the incentive properties of addictive drugs, was induced with a sub-threshold dose of cocaine (1 mg/kg, i.p.). Our results showed that novelty-induced motor activity had a greater predictive capacity to identify "vulnerable-drug" individuals among young-adult mice (PND 56), while the hole-board test was more effective in adolescents (PND 35). High-NR young-adults, which presented higher motor activity in the first ten minutes of the test (novelty-reactivity), were 3.9 times more likely to develop cocaine-induced CPP than Low-NR young-adults. When total activity (1h) was evaluated (novelty-habituation), only High-R (novelty-non-habituating) young-adult male and Low-R (novelty-habituating) female mice produced a high conditioning score. However, only High-Novelty Seeker male and female adolescents and Low-Novelty Seeker female young-adult animals (according to the hole-board test), acquired cocaine-induced CPP. These findings should contribute to the development of screening methods for identifying at-risk human drug users and prevention strategies for those with specific

Computational Fluid Dynamic Simulation of Single Bubble Growth under High-Pressure Pool Boiling Conditions

Directory of Open Access Journals (Sweden)

Janani Murallidharan

2016-08-01

Full Text Available Component-scale modeling of boiling is predominantly based on the Eulerian–Eulerian two-fluid approach. Within this framework, wall boiling is accounted for via the Rensselaer Polytechnic Institute (RPI model and, within this model, the bubble is characterized using three main parameters: departure diameter (D, nucleation site density (N, and departure frequency (f. Typically, the magnitudes of these three parameters are obtained from empirical correlations. However, in recent years, efforts have been directed toward mechanistic modeling of the boiling process. Of the three parameters mentioned above, the departure diameter (D is least affected by the intrinsic uncertainties of the nucleate boiling process. This feature, along with its prominence within the RPI boiling model, has made it the primary candidate for mechanistic modeling ventures. Mechanistic modeling of D is mostly carried out through solving of force balance equations on the bubble. Forces incorporated in these equations are formulated as functions of the radius of the bubble and have been developed for, and applied to, low-pressure conditions only. Conversely, for high-pressure conditions, no mechanistic information is available regarding the growth rates of bubbles and the forces acting on them. In this study, we use direct numerical simulation coupled with an interface tracking method to simulate bubble growth under high (up to 45 bar pressure, to obtain the kind of mechanistic information required for an RPI-type approach. In this study, we compare the resulting bubble growth rate curves with predictions made with existing experimental data.

Bubbles

DEFF Research Database (Denmark)

Dholakia, Nikhilesh; Turcan, Romeo V.

2013-01-01

A goal of our ongoing research stream is to develop a multidisciplinary metatheory of bubbles. In this viewpoint paper we put forward a typology of bubbles by comparing four types of assets – entertainment, commodities, financial securities (stocks), and housing properties – where bubbles could...... and do form occasionally. Cutting across and comparing such varied asset types provides some rich insights into the nature of bubbles – and offers an inductive way to arrive at the typology of bubbles....

Experimental study of vapor bubble dynamics

International Nuclear Information System (INIS)

Pasquini, Maria-Elena

2015-01-01

The object of this thesis is an experimental study of vapor bubble dynamics in sub-cooled nucleate boiling. The test section is locally heated by focusing a laser beam: heat fluxes from 1 e4 to 1.5 e6 W/m 2 and water temperature between 100 and 88 C have been considered. Three boiling regimes have been observed. Under saturated conditions and with low heat fluxes a developed nucleate boiling regime has been observed. Under higher sub-cooling and still with low heat fluxes an equilibrium regime has been observed in which the liquid flowrate evaporating at the bubble base is compensated by the vapor condensing flowrate at bubble top. A third regime have been observed at high heat fluxes for all water conditions: it is characterized by the formation of a large dry spot on the heated surface that keeps the nucleation site dry after bubble detachment. The condensation phase starts after bubble detachment. Bubble equivalent radius at detachment varies between 1 and 2.5 mm. Bubble properties have been measured and non-dimensional groups have been used to characterize bubble dynamics. Capillary waves have been observed on the bubble surface thanks to high-speed images acquisition. Two main phenomena have been proposed to explain capillary waves effects on bubble condensation: increasing of the phases interface area and decreasing of vapor bubble translation velocity, because of the increased drag force on the deformed bubble. (author) [fr

Letter: Entrapment and interaction of an air bubble with an oscillating cavitation bubble

Science.gov (United States)

Kannan, Y. S.; Karri, Badarinath; Sahu, Kirti Chandra

2018-04-01

The mechanism of the formation of an air bubble due to an oscillating cavitation bubble in its vicinity is reported from an experimental study using high-speed imaging. The cavitation bubble is created close to the free surface of water using a low-voltage spark circuit comprising two copper electrodes in contact with each other. Before the bubble is created, a third copper wire is positioned in contact with the free surface of water close to the two crossing electrodes. Due to the surface tension at the triple point (wire-water-air) interface, a small dip is observed in the free surface at the point where the wire is immersed. When the cavitation bubble is created, the bubble pushes at the dip while expanding and pulls at it while collapsing. The collapse phase leads to the entrapment of an air bubble at the wire immersion point. During this phase, the air bubble undergoes a "catapult" effect, i.e., it expands to a maximum size and then collapses with a microjet at the free surface. To the best of our knowledge, this mechanism has not been reported so far. A parametric study is also conducted to understand the effects of wire orientation and bubble distance from the free surface.

Interfacial area transport in a confined Bubbly flow

Energy Technology Data Exchange (ETDEWEB)

Kim, S.; Sun, X.; Ishii, M. [Purdue Univ., Lafayette, IN (United States). School of Nuclear Engineering; Lincoln, F. [Bettis Atomic Power Lab., West Mifflin, Bechtel Bettis, Inc., PA (United States)

2001-07-01

The interfacial area transport equation applicable to the bubbly flow is presented. The model is evaluated against the data acquired in an adiabatic air-water upward two-phase flow loop with a test section of 20 cm in width and 1 cm in gap. In general, a good agreement, within the measurement error of {+-}10%, is observed for a wide range in the bubbly flow regime. The sensitivity analysis on the individual particle interaction mechanisms demonstrates the active interactions between the bubbles and highlights the mechanisms playing the dominant role in interfacial area transport. (author)

Bubbles generated from wind-steepened breaking waves: 1. Bubble plume bubbles

NARCIS (Netherlands)

Leifer, I.; Leeuw, G. de

2006-01-01

Measurements of bubble plumes from paddle-amplified, wind stress breaking waves were made in a large wind-wave channel during the LUMINY experiment in fresh (but not clean) water. Bubble plumes exhibited considerable variability with respect to dynamics, bubble size distribution, and physical

Aspherical bubble dynamics and oscillation times

Energy Technology Data Exchange (ETDEWEB)

Godwin, R.P.; Chapyak, E.J. [Los Alamos National Lab., NM (United States); Noack, J.; Vogel, A. [Medizinisches Laserzentrum Luebeck (Germany)

1999-03-01

The cavitation bubbles common in laser medicine are rarely perfectly spherical and are often located near tissue boundaries, in vessels, etc., which introduce aspherical dynamics. Here, novel features of aspherical bubble dynamics are explored. Time-resolved experimental photographs and simulations of large aspect ratio (length:diameter {approximately}20) cylindrical bubble dynamics are presented. The experiments and calculations exhibit similar dynamics. A small high-pressure cylindrical bubble initially expands radially with hardly any axial motion. Then, after reaching its maximum volume, a cylindrical bubble collapses along its long axis with relatively little radial motion. The growth-collapse period of these very aspherical bubbles differs only sightly from twice the Rayleigh collapse time for a spherical bubble with an equivalent maximum volume. This fact justifies using the temporal interval between the acoustic signals emitted upon bubble creation and collapse to estimate the maximum bubble volume. As a result, hydrophone measurements can provide an estimate of the bubble energy even for aspherical bubbles. The prolongation of the oscillation period of bubbles near solid boundaries relative to that of isolated spherical bubbles is also discussed.

Bubble formation upon crystallization of high nitrogen iron base alloys

International Nuclear Information System (INIS)

Svyazhin, A.G.; Sivka, E.; Skuza, Z.

2000-01-01

A study is made into the conditions of nitrogen bubble formation during crystallization of unalloyed iron, alloys of Fe-O, Fe-O-S systems, steels 1Kh13, 0Kh18N9 and a two-phase Fe-11%Cr-1%Mo-0.2%V steel. It is revealed that the amount of bubbles in a high nitrogen steel casting increases with a degree of nitrogen supersaturation and decreases with a cooling rate growth and with a rise of surfactant concentration in the metal. In sound castings a nitrogen content can be increased due to a cooling rate growth, nitrogen dilution with inert gas, an increase of nitrogen pressure during crystallization as well as due to the introduction of such surfactants as sulphur, selenium, tellurium, tin [ru

Helium accumulation and bubble formation in FeCoNiCr alloy under high fluence He+ implantation

Science.gov (United States)

Chen, Da; Tong, Y.; Li, H.; Wang, J.; Zhao, Y. L.; Hu, Alice; Kai, J. J.

2018-04-01

Face-centered cubic (FCC) high-entropy alloys (HEA), as emerging alloys with equal-molar or near equal-molar constituents, show a promising radiation damage resistance under heavy ion bombardment, making them potential for structural material application in next-generation nuclear reactors, but the accumulation of light helium ions, a product of nuclear fission reaction, has not been studied. The present work experimentally studied the helium accumulation and bubble formation at implantation temperatures of 523 K, 573 K and 673 K in a homogenized FCC FeCoNiCr HEA, a HEA showing excellent radiation damage resistance under heavy ion irradiation. The size and population density of helium bubbles in FeCoNiCr samples were quantitatively analyzed through transmission electron microscopy (TEM), and the helium content existing in bubbles were estimated from a high-pressure Equation of State (EOS). We found that the helium diffusion in such condition was dominated by the self-interstitial/He replacement mechanism, and the corresponding activation energy in FeCoNiCr is comparable with the vacancy migration energy in Ni and austenitic stainless steel but only 14.3%, 31.4% and 51.4% of the accumulated helium precipitated into helium bubbles at 523 K, 573 K and 673 K, respectively, smaller than the pure Ni case. Importantly, the small bubble size suggested that FeCoNiCr HEA has a high resistance of helium bubble formation compared with Ni and steels.

High-resolution 8-13 micron imaging of the planetary nebulae BD + 30 deg 3639 and NGC 6572

International Nuclear Information System (INIS)

Hora, J.L.; Hoffmann, W.F.; Deutsch, L.K.; Fazio, G.G.

1990-01-01

High-resolution midinfrared images of the planetary nebulae BD + 30 deg 3639 and NGC 6572 are presented at 8.3, 8.7, 9.8, 11.2, and 12.4 microns. Analysis of the maps of BD + 30 deg 3639 supports a model in which the infrared emission originates from two spatially distinct components, one which is responsible for the continuum radiation at 8-12 microns and the other which produces the emission-line features. The NGC 6572 images provides evidence for a previously undetected 11.2 micron UIR emission feature. Comparison with radio continuum maps indicates that the distribution of dust is similar to the distribution of ionized gas in each nebula. Various models of source morphology are also investigated. The planetary nebulae DB + 30 deg 3639 and NGC 6572 can be modeled by an optically thin cylinder or a prolate ellipsoid with enhanced equatorial emission. These models reproduce well the general features of the nebula, such as the bipolar lobes of emission and the ring structure. 67 refs

High speed ultrasonic system to measure bubbles velocities in a horizontal two-phase flow

International Nuclear Information System (INIS)

Cunha Filho, Jurandyr S.; Jian Su; Farias, Marcos S.; Faccini, Jose L.H.; Lamy, Carlos A.

2009-01-01

In this work, a non invasive technique consisting of a high speed ultrasonic multitransducer pulse-echo system was developed to characterize gas-liquid two-phase flow parameters that are important in the study of the primary refrigeration circuit of nuclear reactors. The high speed ultrasonic system consists of two transducers (10 MHz/φ 6.35 mm), a generator/multiplexer board, and software that selects and has a data acquisition system of the ultrasonic signals. The resolutions of the system and the pulse time generated from each transducer are, respectively, 10 ns and 1.06 ms. The system initially was used in the local instantaneous measurement of gas-liquid interface in a circular horizontal pipe test section made of a 5 m long stainless steel pipe of 51.2 mm inner diameter, where the elongated bubbles velocity was measured (Taylor bubbles). The results show that the high speed ultrasonic pulse-echo system provides good results for the determination of elongated bubbles velocities. (author)

Detection potential of the KM3NeT detector for high-energy neutrinos from the Fermi bubbles

Science.gov (United States)

KM3NeT Collaboration; Adrián-Martínez, S.; Ageron, M.; Aguilar, J. A.; Aharonian, F.; Aiello, S.; Albert, A.; Alexandri, M.; Ameli, F.; Anassontzis, E. G.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Assis Jesus, A.; Aubert, J.-J.; Bakker, R.; Ball, A. E.; Barbarino, G.; Barbarito, E.; Barbato, F.; Baret, B.; de Bel, M.; Belias, A.; Bellou, N.; Berbee, E.; Berkien, A.; Bersani, A.; Bertin, V.; Beurthey, S.; Biagi, S.; Bigongiari, C.; Bigourdan, B.; Billault, M.; de Boer, R.; Boer Rookhuizen, H.; Bonori, M.; Borghini, M.; Bou-Cabo, M.; Bouhadef, B.; Bourlis, G.; Bouwhuis, M.; Bradbury, S.; Brown, A.; Bruni, F.; Brunner, J.; Brunoldi, M.; Busto, J.; Cacopardo, G.; Caillat, L.; Calvo Díaz-Aldagalán, D.; Calzas, A.; Canals, M.; Capone, A.; Carr, J.; Castorina, E.; Cecchini, S.; Ceres, A.; Cereseto, R.; Chaleil, Th.; Chateau, F.; Chiarusi, T.; Choqueuse, D.; Christopoulou, P. E.; Chronis, G.; Ciaffoni, O.; Circella, M.; Cocimano, R.; Cohen, F.; Colijn, F.; Coniglione, R.; Cordelli, M.; Cosquer, A.; Costa, M.; Coyle, P.; Craig, J.; Creusot, A.; Curtil, C.; D'Amico, A.; Damy, G.; De Asmundis, R.; De Bonis, G.; Decock, G.; Decowski, P.; Delagnes, E.; De Rosa, G.; Distefano, C.; Donzaud, C.; Dornic, D.; Dorosti-Hasankiadeh, Q.; Drogou, J.; Drouhin, D.; Druillole, F.; Drury, L.; Durand, D.; Durand, G. A.; Eberl, T.; Emanuele, U.; Enzenhöfer, A.; Ernenwein, J.-P.; Escoffier, S.; Espinosa, V.; Etiope, G.; Favali, P.; Felea, D.; Ferri, M.; Ferry, S.; Flaminio, V.; Folger, F.; Fotiou, A.; Fritsch, U.; Gajanana, D.; Garaguso, R.; Gasparini, G. P.; Gasparoni, F.; Gautard, V.; Gensolen, F.; Geyer, K.; Giacomelli, G.; Gialas, I.; Giordano, V.; Giraud, J.; Gizani, N.; Gleixner, A.; Gojak, C.; Gómez-González, J. P.; Graf, K.; Grasso, D.; Grimaldi, A.; Groenewegen, R.; Guédé, Z.; Guillard, G.; Guilloux, F.; Habel, R.; Hallewell, G.; van Haren, H.; van Heerwaarden, J.; Heijboer, A.; Heine, E.; Hernández-Rey, J. J.; Herold, B.; Hillebrand, T.; van de Hoek, M.; Hogenbirk, J.; Hößl, J.; Hsu, C. C.; Imbesi, M.; Jamieson, A.; Jansweijer, P.; de Jong, M.; Jouvenot, F.; Kadler, M.; Kalantar-Nayestanaki, N.; Kalekin, O.; Kappes, A.; Karolak, M.; Katz, U. F.; Kavatsyuk, O.; Keller, P.; Kiskiras, Y.; Klein, R.; Kok, H.; Kontoyiannis, H.; Kooijman, P.; Koopstra, J.; Kopper, C.; Korporaal, A.; Koske, P.; Kouchner, A.; Koutsoukos, S.; Kreykenbohm, I.; Kulikovskiy, V.; Laan, M.; La Fratta, C.; Lagier, P.; Lahmann, R.; Lamare, P.; Larosa, G.; Lattuada, D.; Leisos, A.; Lenis, D.; Leonora, E.; Le Provost, H.; Lim, G.; Llorens, C. D.; Lloret, J.; Löhner, H.; Lo Presti, D.; Lotrus, P.; Louis, F.; Lucarelli, F.; Lykousis, V.; Malyshev, D.; Mangano, S.; Marcoulaki, E. C.; Margiotta, A.; Marinaro, G.; Marinelli, A.; Mariş, O.; Markopoulos, E.; Markou, C.; Martínez-Mora, J. A.; Martini, A.; Marvaldi, J.; Masullo, R.; Maurin, G.; Migliozzi, P.; Migneco, E.; Minutoli, S.; Miraglia, A.; Mollo, C. M.; Mongelli, M.; Monmarthe, E.; Morganti, M.; Mos, S.; Motz, H.; Moudden, Y.; Mul, G.; Musico, P.; Musumeci, M.; Naumann, Ch.; Neff, M.; Nicolaou, C.; Orlando, A.; Palioselitis, D.; Papageorgiou, K.; Papaikonomou, A.; Papaleo, R.; Papazoglou, I. A.; Păvălaş, G. E.; Peek, H. Z.; Perkin, J.; Piattelli, P.; Popa, V.; Pradier, T.; Presani, E.; Priede, I. G.; Psallidas, A.; Rabouille, C.; Racca, C.; Radu, A.; Randazzo, N.; Rapidis, P. A.; Razis, P.; Real, D.; Reed, C.; Reito, S.; Resvanis, L. K.; Riccobene, G.; Richter, R.; Roensch, K.; Rolin, J.; Rose, J.; Roux, J.; Rovelli, A.; Russo, A.; Russo, G. V.; Salesa, F.; Samtleben, D.; Sapienza, P.; Schmelling, J.-W.; Schmid, J.; Schnabel, J.; Schroeder, K.; Schuller, J.-P.; Schussler, F.; Sciliberto, D.; Sedita, M.; Seitz, T.; Shanidze, R.; Simeone, F.; Siotis, I.; Sipala, V.; Sollima, C.; Sparnocchia, S.; Spies, A.; Spurio, M.; Staller, T.; Stavrakakis, S.; Stavropoulos, G.; Steijger, J.; Stolarczyk, Th.; Stransky, D.; Taiuti, M.; Taylor, A.; Thompson, L.; Timmer, P.; Tonoiu, D.; Toscano, S.; Touramanis, C.; Trasatti, L.; Traverso, P.; Trovato, A.; Tsirigotis, A.; Tzamarias, S.; Tzamariudaki, E.; Urbano, F.; Vallage, B.; Van Elewyck, V.; Vannoni, G.; Vecchi, M.; Vernin, P.; Viola, S.; Vivolo, D.; Wagner, S.; Werneke, P.; White, R. J.; Wijnker, G.; Wilms, J.; de Wolf, E.; Yepes, H.; Zhukov, V.; Zonca, E.; Zornoza, J. D.; Zúñiga, J.

2013-02-01

A recent analysis of the Fermi Large Area Telescope data provided evidence for a high-intensity emission of high-energy gamma rays with a E-2 spectrum from two large areas, spanning 50° above and below the Galactic centre (the "Fermi bubbles"). A hadronic mechanism was proposed for this gamma-ray emission making the Fermi bubbles promising source candidates of high-energy neutrino emission. In this work Monte Carlo simulations regarding the detectability of high-energy neutrinos from the Fermi bubbles with the future multi-km3 neutrino telescope KM3NeT in the Mediterranean Sea are presented. Under the hypothesis that the gamma-ray emission is completely due to hadronic processes, the results indicate that neutrinos from the bubbles could be discovered in about one year of operation, for a neutrino spectrum with a cutoff at 100 TeV and a detector with about 6 km3 of instrumented volume. The effect of a possible lower cutoff is also considered.

Anti-Bubbles

Science.gov (United States)

Tufaile, Alberto; Sartorelli, José Carlos

2003-08-01

An anti-bubble is a striking kind of bubble in liquid that seemingly does not comply the buoyancy, and after few minutes it disappears suddenly inside the liquid. Different from a simple air bubble that rises directly to the liquid surface, an anti-bubble wanders around in the fluid due to its slightly lesser density than the surrounding liquid. In spite of this odd behavior, an anti-bubble can be understood as the opposite of a conventional soap bubble in air, which is a shell of liquid surrounding air, and an anti-bubble is a shell of air surrounding a drop of the liquid inside the liquid. Two-phase flow has been a subject of interest due to its relevance to process equipment for contacting gases and liquids applied in industry. A chain of bubbles rising in a liquid formed from a nozzle is a two-phase flow, and there are certain conditions in which spherical air shells, called anti-bubbles, are produced. The purpose of this work is mainly to note the existence of anti-bubbling regime as a sequel of a bubbling system. We initially have presented the experimental apparatus. After this we have described the evolution of the bubbling regimes, and emulated the effect of bubbling coalescence with simple maps. Then is shown the inverted dripping as a consequence of the bubble coalescence, and finally the conditions for anti-bubble formation.

Study of droplet entrainment from bubbling surface in a bubble column

International Nuclear Information System (INIS)

Ramirez de Santiago, M.

1991-05-01

In a bubble column droplets are ejected from the free surface by bubble bursting or splashing. Depending on their size, the droplets are partly carried away by the streaming gas or fall back to the bubbling surface by gravity force. Experiments have been carried out to determine the void fraction in the column by means of an optical probe. In the interfacial zone the bubble bursting process was captured with a high-speed video camera. Simultaneous measurements were made of size and velocity of droplets at several distances from the bubbling surface with a Phase-Doppler Anemometry. The bubble column can be divided into three regions: A lower zone with a flat profile of the local void fraction, a central zone where the flow regime is steady and an upper zone where the local void fraction grows rapidly. A two-parameter log-normal distribution function was proposed in order to describe the polydisperse distribution of droplet-size. Results were obtained concerning the entrainment, concentration, volume fraction and interfacial area of droplets. Finally, it was found that the turbulence intensity affects the droplet terminal velocity for droplets smaller than the Kolmogorov microscale [fr

Bubble properties of heterogeneous bubbly flow in a square bubble column

NARCIS (Netherlands)

Bai, Wei; Deen, Niels G.; Kuipers, J.A.M.

2010-01-01

The present work focuses on the measurements of bubble properties in heterogeneous bubbly flows in a square bubble column. A four-point optical fibre probe was used for this purpose. The accuracy and intrusive effect of the optical probe was investigated first. The results show that the optical

Bubbles with shock waves and ultrasound: a review.

Science.gov (United States)

Ohl, Siew-Wan; Klaseboer, Evert; Khoo, Boo Cheong

2015-10-06

The study of the interaction of bubbles with shock waves and ultrasound is sometimes termed 'acoustic cavitation'. It is of importance in many biomedical applications where sound waves are applied. The use of shock waves and ultrasound in medical treatments is appealing because of their non-invasiveness. In this review, we present a variety of acoustics-bubble interactions, with a focus on shock wave-bubble interaction and bubble cloud phenomena. The dynamics of a single spherically oscillating bubble is rather well understood. However, when there is a nearby surface, the bubble often collapses non-spherically with a high-speed jet. The direction of the jet depends on the 'resistance' of the boundary: the bubble jets towards a rigid boundary, splits up near an elastic boundary, and jets away from a free surface. The presence of a shock wave complicates the bubble dynamics further. We shall discuss both experimental studies using high-speed photography and numerical simulations involving shock wave-bubble interaction. In biomedical applications, instead of a single bubble, often clouds of bubbles appear (consisting of many individual bubbles). The dynamics of such a bubble cloud is even more complex. We shall show some of the phenomena observed in a high-intensity focused ultrasound (HIFU) field. The nonlinear nature of the sound field and the complex inter-bubble interaction in a cloud present challenges to a comprehensive understanding of the physics of the bubble cloud in HIFU. We conclude the article with some comments on the challenges ahead.

RVX-297- a novel BD2 selective inhibitor of BET bromodomains

Energy Technology Data Exchange (ETDEWEB)

Kharenko, Olesya A., E-mail: olesya@zenithepigenetics.com [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); Gesner, Emily M.; Patel, Reena G.; Norek, Karen [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); White, Andre; Fontano, Eric; Suto, Robert K. [Xtal BioStructures, Inc., 12 Michigan Dr., Natick, MA 01760 (United States); Young, Peter R.; McLure, Kevin G.; Hansen, Henrik C. [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada)

2016-08-12

Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET inhibitor RVX-297 that is structurally related to the clinical compound RVX-208, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. We report that RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. We demonstrate the differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography, and describe the structural differences driving the BD2 selective binding of RVX-297. The isothermal titration calorimetry (ITC) data illustrate the related differential thermodynamics of binding of RVX-297 to single as well as dual BET bromodomains. - Highlights: • A novel inhibitor of BET bromodomains, RVX-297 is described. • The differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography are described. • RVX-297 preferentially binds to the BD2 domains of the BET bromodomains. • The structural and thermodynamic properties of the BD2 selective binding of RVX-297 are characterized.

Investigation of hydrogen bubbles behavior in tungsten by high-flux hydrogen implantation

Science.gov (United States)

Zhao, Jiangtao; Meng, Xuan; Guan, Xingcai; Wang, Qiang; Fang, Kaihong; Xu, Xiaohui; Lu, Yongkai; Gao, Jun; Liu, Zhenlin; Wang, Tieshan

2018-05-01

Hydrogen isotopes retention and bubbles formation are critical issues for tungsten as plasma-facing material in future fusion reactors. In this work, the formation and growing up behavior of hydrogen bubbles in tungsten were investigated experimentally. The planar TEM samples were implanted by 6.0keV hydrogens to a fluence of 3.38 ×1018 H ṡ cm-2 at room temperature, and well-defined hydrogen bubbles were observed by TEM. It was demonstrated that hydrogen bubbles formed when exposed to a fluence of 1.5 ×1018 H ṡ cm-2 , and the hydrogen bubbles grew up with the implantation fluence. In addition, the bubbles' size appeared larger with higher beam flux until saturated at a certain flux, even though the total fluence was kept the same. Finally, in order to understand the thermal annealing effect on the bubbles behavior, hydrogen-implanted samples were annealed at 400, 600, 800, and 1000 °C for 3 h. It was obvious that hydrogen bubbles' morphology changed at temperatures higher than 800 °C.

Effect of inhomogeneities on streamer propagation: II. Streamer dynamics in high pressure humid air with bubbles

International Nuclear Information System (INIS)

Babaeva, Natalia Yu; Kushner, Mark J

2009-01-01

The branching of electric discharge streamers in atmospheric pressure air, dense gases and liquids is a common occurrence whose origins are likely found with many causes, both deterministic and stochastic. One mechanism for streamer branching may be inhomogeneities in the path of a streamer which either divert the streamer (typically a region of lower ionization) or produce a new branch (a region of higher ionization). The propagation and branching of streamers in liquids is likely aided by low density inhomogeneities, bubbles; however, modeling of streamers in liquids is made difficult by the lack of transport coefficients. As a first step towards understanding the propagation and branching of streamers in liquids, we investigated the consequences of random inhomogeneities in the form of low pressure bubbles on the propagation of streamers in high pressure humid air. By virtue of their lower density, bubbles have larger E/N (electric field/gas number density) than the ambient gas with larger rates of ionization. The intersection of a streamer with a bubble will focus the plasma into the bubble by virtue of that higher rate of ionization but the details of the interaction depend on the relative sizes of the bubble and streamer. When a streamer intersects a field of bubbles, the large E/N in the bubble avalanches seed electrons produced by photoionization from the streamer. Each bubble then launches both a negative and positive going streamer that may link with those from adjacent bubbles or the original streamer. The total process then appears as streamer branching.

Fermi Bubble: Giant Gamma-Ray Bubbles in the Milky Way

Science.gov (United States)

Su, Meng

Data from the Fermi-LAT reveal two gigantic gamma-ray emitting bubble structures (known as the Fermibubbles), extending˜50° above and below the Galactic center symmetric about the Galactic plane, with a width of˜40∘ in longitude. The gamma-ray emission associated with these bubbles has a significantly harder spectrum ({dN}/{dE} ˜ {E}^{-2}) than the inverse Compton emission from known cosmic ray electrons in the Galactic disk, or the gamma-rays produced by decay of pions from proton-ISM collisions. The bubbles are spatially correlated with the hard-spectrum microwave excess known as the WMAPhaze; the edges of the bubbles also line up with features in the ROSATsoft X-ray maps at 1.5-2keV. The Fermibubble is most likely created by some large episode of energy injection in the Galactic center, such as past accretion events onto the central massive black hole, or a nuclear starburst in the last˜10Myr. Study of the origin and evolution of the bubbles also has the potential to improve our understanding of recent energetic events in the inner Galaxy and the high-latitude cosmic ray population.

Bubble Radiation Detection: Current and Future Capability

International Nuclear Information System (INIS)

Peurrung, A.J.; Craig, R.A.

1999-01-01

Despite a number of noteworthy achievements in other fields, superheated droplet detectors (SDDs) and bubble chambers (BCs) have not been used for nuclear nonproliferation and arms control. This report examines these two radiation-detection technologies in detail and answers the question of how they can be or should be ''adapted'' for use in national security applications. These technologies involve closely related approaches to radiation detection in which an energetic charged particle deposits sufficient energy to initiate the process of bubble nucleation in a superheated fluid. These detectors offer complete gamma-ray insensitivity when used to detect neutrons. They also provide controllable neutron-energy thresholds and excellent position resolution. SDDs are extraordinarily simple and inexpensive. BCs offer the promise of very high efficiency (∼75%). A notable drawback for both technologies is temperature sensitivity. As a result of this problem, the temperature must be controlled whenever high accuracy is required, or harsh environmental conditions are encountered. The primary findings of this work are listed and briefly summarized below: (1) SDDs are ready to function as electronics-free neutron detectors on demand for arms-control applications. The elimination of electronics at the weapon's location greatly eases the negotiability of radiation-detection technologies in general. (2) As a result of their high efficiency and sharp energy threshold, current BCs are almost ready for use in the development of a next-generation active assay system. Development of an instrument based on appropriately safe materials is warranted. (3) Both kinds of bubble detectors are ready for use whenever very high gamma-ray fields must be confronted. Spent fuel MPC and A is a good example where this need presents itself. (4) Both kinds of bubble detectors have the potential to function as low-cost replacements for conventional neutron detectors such as 3 He tubes. For SDDs

Effect of an entrained air bubble on the acoustics of an ink channel

NARCIS (Netherlands)

Jeurissen, R.J.M.; Jong, de J.; Reinten, H.; Berg, van den M.; Wijshoff, H.M.A.; Versluis, M.; Lohse, D.

2008-01-01

Piezo-driven inkjet systems are very sensitive to air entrapment. The entrapped air bubbles grow by rectified diffusion in the ink channel and finally result in nozzle failure. Experimental results on the dynamics of fully grown air bubbles are presented. It is found that the bubble counteracts the

Comparison of the identification results of Candida species obtained by BD Phoenix™ and Maldi-TOF (Bruker Microflex LT Biotyper 3.1).

Science.gov (United States)

Marucco, Andrea P; Minervini, Patricia; Snitman, Gabriela V; Sorge, Adriana; Guelfand, Liliana I; Moral, Laura López

2018-02-05

In patients with invasive fungal infections, the accurate and rapid identification of the genus Candida is of utmost importance since antimycotic sensitivity is closely related to the species. The aim of the present study was to compare the identification results of species of the genus Candida obtained by BD Phoenix™ (Becton Dickinson [BD]) and Maldi-TOF MS (Bruker Microflex LT Biotyper 3.1). A total of 192 isolates from the strain collection belonging to the Mycology Network of the Autonomous City of Buenos Aires, Argentina, were analyzed. The observed concordance was 95%. Only 10 strains (5%) were not correctly identified by the BD Phoenix™ system. The average identification time with the Yeast ID panels was 8h 22min. The BD Phoenix™ system proved to be a simple, reliable and effective method for identifying the main species of the genus Candida. Copyright © 2017 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

Geomagnetically conjugate observation of plasma bubbles and thermospheric neutral winds at low latitudes

Science.gov (United States)

Fukushima, D.; Shiokawa, K.; Otsuka, Y.; Nishioka, M.; Kubota, M.; Tsugawa, T.; Nagatsuma, T.; Komonjinda, S.; Yatini, C. Y.

2015-03-01

This is the first paper that reports simultaneous observations of zonal drift of plasma bubbles and the thermospheric neutral winds at geomagnetically conjugate points in both hemispheres. The plasma bubbles were observed in the 630 nm nighttime airglow images taken by using highly sensitive all-sky airglow imagers at Kototabang, Indonesia (geomagnetic latitude (MLAT): 10.0°S), and Chiang Mai, Thailand (MLAT: 8.9°N), which are nearly geomagnetically conjugate stations, for 7 h from 13 to 20 UT (from 20 to 03 LT) on 5 April 2011. The bubbles continuously propagated eastward with velocities of 100-125 m/s. The 630 nm images at Chiang Mai and those mapped to the conjugate point of Kototabang fit very well, which indicates that the observed plasma bubbles were geomagnetically connected. The eastward thermospheric neutral winds measured by two Fabry-Perot interferometers were 70-130 m/s at Kototabang and 50-90 m/s at Chiang Mai. We compared the observed plasma bubble drift velocity with the velocity calculated from the observed neutral winds and the model conductivity, to investigate the F region dynamo contribution to the bubble drift velocity. The estimated drift velocities were 60-90% of the observed velocities of the plasma bubbles, suggesting that most of the plasma bubble velocity can be explained by the F region dynamo effect.

Bidirectional cinematography of steam-bubble growth

Energy Technology Data Exchange (ETDEWEB)

Deason, V.A.; Reynolds, L.D.

1982-01-01

Single steam bubbles were generated in superheated water in an optical cell. The growth process of the bubbles was recorded with a high-speed motion picture camera at 5000 and 10,000 frames per second. A technique was developed to simultaneously image two orthogonal views of the bubbles on each frame of film. The vertical and horizontal diameters of the bubbles were measured on a frame-by-frame basis, and the data analyzed to determine oscillatory frequencies. The analysis also attempted to determine whether the bubbles were undergoing volumetric oscillations during early growth or whether simple surface wave/rotational behavior caused the observed periodic variations in bubble dimensions. For the bubbles studied, typical oscillation frequencies for the diameters were in the range of 100 to 500 Hz.

Bidirectional cinematography of steam-bubble growth

International Nuclear Information System (INIS)

Deason, V.A.; Reynolds, L.D.

1982-01-01

Single steam bubbles were generated in superheated water in an optical cell. The growth process of the bubbles was recorded with a high-speed motion picture camera at 5000 and 10,000 frames per second. A technique was developed to simultaneously image two orthogonal views of the bubbles on each frame of film. The vertical and horizontal diameters of the bubbles were measured on a frame-by-frame basis, and the data analyzed to determine oscillatory frequencies. The analysis also attempted to determine whether the bubbles were undergoing volumetric oscillations during early growth or whether simple surface wave/rotational behavior caused the observed periodic variations in bubble dimensions. For the bubbles studied, typical oscillation frequencies for the diameters were in the range of 100 to 500 Hz

Clinical and analytical performance of the BD Onclarity™ HPV assay for detection of CIN2+ lesions on SurePath samples

DEFF Research Database (Denmark)

Ejegod, Ditte Møller; Junge, Jette; Franzmann, Maria

2016-01-01

BACKGROUND: The novel BD Onclarity(TM) HPV assay (Onclarity) on the BD Viper™ LT system (BD Diagnostics, Sparks, MD), detects E6/E7 DNA from 13 high-risk HPV genotypes and HPV66. We compared the analytical and clinical performance of the Onclarity Assay to that of Hybrid Capture 2 and LINEAR ARRAY...

Bd/s -> mu+ mu- in ATLAS

CERN Document Server

Guenther, Jaroslav; The ATLAS collaboration

2016-01-01

The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied to provide new results presented in this talk. An upper limit is set on the branching ratio BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

Search for Very High-energy Gamma Rays from the Northern Fermi Bubble Region with HAWC

OpenAIRE

Abeysekara, AU; Albert, A; Alfaro, R; Alvarez, C; Alvarez, JD; Arceo, R; Arteaga-Velázquez, JC; Ayala Solares, HA; Barber, AS; Bautista-Elivar, N; Becerril, A; Belmont-Moreno, E; BenZvi, SY; Berley, D; Braun, J

2017-01-01

© 2017. The American Astronomical Society. All rights reserved. We present a search for very high-energy gamma-ray emission from the Northern Fermi Bubble region using data collected with the High Altitude Water Cherenkov gamma-ray observatory. The size of the data set is 290 days. No significant excess is observed in the Northern Fermi Bubble region, so upper limits above 1 TeV are calculated. The upper limits are between and . The upper limits disfavor a proton injection spectrum that exten...

Generating Soap Bubbles by Blowing on Soap Films

Science.gov (United States)

Salkin, Louis; Schmit, Alexandre; Panizza, Pascal; Courbin, Laurent

2016-02-01

Making soap bubbles by blowing air on a soap film is an enjoyable activity, yet a poorly understood phenomenon. Working either with circular bubble wands or long-lived vertical soap films having an adjustable steady state thickness, we investigate the formation of such bubbles when a gas is blown through a nozzle onto a film. We vary film size, nozzle radius, space between the film and nozzle, and gas density, and we measure the gas velocity threshold above which bubbles are formed. The response is sensitive to containment, i.e., the ratio between film and jet sizes, and dissipation in the turbulent gas jet, which is a function of the distance from the film to the nozzle. We rationalize the observed four different regimes by comparing the dynamic pressure exerted by the jet on the film and the Laplace pressure needed to create the curved surface of a bubble. This simple model allows us to account for the interplay between hydrodynamic, physicochemical, and geometrical factors.

High-Frequency Fiber-Optic Ultrasonic Sensor Using Air Micro-Bubble for Imaging of Seismic Physical Models.

Science.gov (United States)

Gang, Tingting; Hu, Manli; Rong, Qiangzhou; Qiao, Xueguang; Liang, Lei; Liu, Nan; Tong, Rongxin; Liu, Xiaobo; Bian, Ce

2016-12-14

A micro-fiber-optic Fabry-Perot interferometer (FPI) is proposed and demonstrated experimentally for ultrasonic imaging of seismic physical models. The device consists of a micro-bubble followed by the end of a single-mode fiber (SMF). The micro-structure is formed by the discharging operation on a short segment of hollow-core fiber (HCF) that is spliced to the SMF. This micro FPI is sensitive to ultrasonic waves (UWs), especially to the high-frequency (up to 10 MHz) UW, thanks to its ultra-thin cavity wall and micro-diameter. A side-band filter technology is employed for the UW interrogation, and then the high signal-to-noise ratio (SNR) UW signal is achieved. Eventually the sensor is used for lateral imaging of the physical model by scanning UW detection and two-dimensional signal reconstruction.

Nuclear hBD-1 accumulation in malignant salivary gland tumours

International Nuclear Information System (INIS)

Wenghoefer, M; Merkelbach-Bruse, S; Fischer, HP; Novak, N; Winter, J; Pantelis, A; Dommisch, H; Götz, W; Reich, R; Bergé, S; Martini, M; Allam, JP; Jepsen, S

2008-01-01

Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue. 21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3. HBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining. HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours. As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation

Bubble dynamics equations in Newton fluid

International Nuclear Information System (INIS)

Xiao, J

2008-01-01

For the high-speed flow of Newton fluid, bubble is produced and expanded when it moves toward the surface of fluid. Bubble dynamics is a very important research field to understand the intrinsic feature of bubble production and motion. This research formulates the bubble expansion by expansion-local rotation transformation, which can be calculated by the measured velocity field. Then, the related dynamic equations are established to describe the interaction between the fluid and the bubble. The research shows that the bubble production condition can be expressed by critical vortex value and fluid pressure; and the bubble expansion rate can be obtained by solving the non-linear dynamic equation of bubble motion. The results may help the related research as it shows a special kind of fluid motion in theoretic sense. As an application example, the nanofiber radium-voltage relation and threshold voltage-surface tension relation in electrospinning process are discussed

Far ultraviolet spectrophotometry of BD +28 4211

Science.gov (United States)

Cook, Timothy A.; Cash, Webster; Green, James C.

1991-01-01

The results are reported of a November 1989 rocket flight which recorded a flux-calibrated spectrum of BD +28 4211 from 912 to 1150 A with 1A resolution. BD +28 4211, an SdO-type star, is commonly used as an ultraviolet calibration source in the IUE wavelength band. The present work extends the useful range of this standard shortward of Lyman-alpha. Since previous experiments show marked disparity, this study can be useful in determining a standard in the 912 to 1216 A band.

Mode transition in bubbly Taylor-Couette flow measured by PTV

International Nuclear Information System (INIS)

Yoshida, K; Tasaka, Y; Murai, Y; Takeda, T

2009-01-01

The drag acting to the inner cylinder in Taylor-Couette flow system can be reduced by bubble injection. In this research, relationship between drag reduction and change of vortical structure in a Taylor-Couette flow is investigated by Particle Tracking Velocimetry (PTV). The velocity vector field in the r-z cross section and the bubble concentration in the front view (z-θ plane) are measured. This paper describes the change of vortical structures with bubbles, and the mode transition that is sensitively affected by the bubbles is discussed. The bubbles accumulate in the three parts relative to vortex position by the interaction between bubbles and vortices. The status of bubble's distribution is different depending on position. This difference affects mode transition as its trigger significantly. The presence of bubbles affects the transition from toroidal mode to spiral mode but does not induce the transition from spiral mode to toroidal mode. Further we found that Taylor vortex bifurcates and a pair of vortices coalesces when the flow switches between spiral mode and toroidal mode.

Search for direct evidence for charm in hadronic interactions using a high-resolution bubble chamber

CERN Multimedia

2002-01-01

A high-resolution rapid-cycling hydrogen bubble chamber will be used to search for direct evidence of charmed-particle production in $\\sim$350 GeV/c $\\pi^{-}$ interactions. The chamber is 20 cm in diameter and contains $\\sim$1l of liquid hydrogen. The bright field optical system is designed to achieve a resolution in space $\\simeq$ 20-30 $\\mu$m (optical depth of field 2-4 mm), which should allow the detection of charmed-particle decay vertices in complex events if $\\tau_{charm} \\geq 10^{-13}$ sec. An interaction trigger will be used to give an initial sensitivity $\\sim$5-10 events/$\\mu$b for a test run designed primarily to search for the signal and establish a cross-section and approximate lifetime for charm.

Influence of Bubble-Bubble interactions on the macroscale circulation patterns in a bubbling gas-solid fluidized bed

NARCIS (Netherlands)

Laverman, J.A.; van Sint Annaland, M.; Kuipers, J.A.M.

2007-01-01

The macro-scale circulation patterns in the emulsion phase of a gas-solid fluidized bed in the bubbling regime have been studied with a 3D Discrete Bubble Model. It has been shown that bubble-bubble interactions strongly influence the extent of the solids circulation and the bubble size

Fixed Combination Aerosol Foam Calcipotriene 0.005% (Cal) Plus Betamethasone Dipropionate 0.064% (BD) is More Efficacious than Cal or BD Aerosol Foam Alone for Psoriasis Vulgaris

Science.gov (United States)

Tyring, Stephen; Bukhalo, Michael; Alonso-Llamazares, Javier; Olesen, Martin; Lowson, David; Yamauchi, Paul

2016-01-01

Objective: To evaluate the efficacy of fixed combination aerosol foam calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD). Design: Patients were randomized (100:101:101) to receive Cal/BD foam, Cal foam, or BD foam once daily for four weeks. Setting: Twenty-eight United States centers. Participants: 302 patients (≥18 years) with Psoriasis vulgaris (plaque Psoriasis; ≥mild disease severity by physicians global assessment). Measurements: Treatment success of the body (“clear”/”almost clear” from baseline moderate/severe disease; “clear” from baseline mild disease). Involved scalp treatment success was an additional endpoint. Results: Most patients (76%) had moderate Psoriasis of the body (66% for scalp). At Week 4, 45 percent of Cal/BD foam patients achieved treatment success, significantly more than Cal foam (14.9%; OR 4.34 [95%CI 2.16,8.72] Pfoam (30.7%; 1.81 [1.00,3.26] P=0.047). Fifty-three percent of Cal/BD foam patients achieved treatment success of the scalp, significantly greater than Cal foam (35.6%; 1.91 [1.09,3.35] P=0.021), but not BD foam (47.5%; 1.24 [0.71,2.16] P=0.45). Mean modified Psoriasis area and severity index (population baseline 7.6) improved in all groups, with statistically significant differences in Week 4 Cal/BD foam score (2.37) versus Cal foam (4.39; mean difference -2.03 [-2.63][-1.43] Pfoam (3.37; -1.19 [-1.80][-0.59] Pfoam was significantly more effective than Cal foam and BD foam in providing treatment success at Week 4 and effective on involved scalp. Trial registration: NCT01536938. PMID:27313822

Freezing Bubbles

Science.gov (United States)

Kingett, Christian; Ahmadi, Farzad; Nath, Saurabh; Boreyko, Jonathan

2017-11-01

The two-stage freezing process of a liquid droplet on a substrate is well known; however, how bubbles freeze has not yet been studied. We first deposited bubbles on a silicon substrate that was chilled at temperatures ranging from -10 °C to -40 °C, while the air was at room temperature. We observed that the freeze front moved very slowly up the bubble, and in some cases, even came to a complete halt at a critical height. This slow freezing front propagation can be explained by the low thermal conductivity of the thin soap film, and can be observed more clearly when the bubble size or the surface temperature is increased. This delayed freezing allows the frozen portion of the bubble to cool the air within the bubble while the top part is still liquid, which induces a vapor pressure mismatch that either collapses the top or causes the top to pop. In cases where the freeze front reaches the top of the bubble, a portion of the top may melt and slowly refreeze; this can happen more than just once for a single bubble. We also investigated freezing bubbles inside of a freezer where the air was held at -20 °C. In this case, the bubbles freeze quickly and the ice grows radially from nucleation sites instead of perpendicular to the surface, which provides a clear contrast with the conduction limited room temperature bubbles.

Improvement in the amine glass platform by bubbling method for a DNA microarray

Directory of Open Access Journals (Sweden)

Jee SH

2015-10-01

Full Text Available Seung Hyun Jee,1 Jong Won Kim,2 Ji Hyeong Lee,2 Young Soo Yoon11Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi, Republic of Korea; 2Genomics Clinical Research Institute, LabGenomics Co., Ltd., Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of KoreaAbstract: A glass platform with high sensitivity for sexually transmitted diseases microarray is described here. An amino-silane-based self-assembled monolayer was coated on the surface of a glass platform using a novel bubbling method. The optimized surface of the glass platform had highly uniform surface modifications using this method, as well as improved hybridization properties with capture probes in the DNA microarray. On the basis of these results, the improved glass platform serves as a highly reliable and optimal material for the DNA microarray. Moreover, in this study, we demonstrated that our glass platform, manufactured by utilizing the bubbling method, had higher uniformity, shorter processing time, lower background signal, and higher spot signal than the platforms manufactured by the general dipping method. The DNA microarray manufactured with a glass platform prepared using bubbling method can be used as a clinical diagnostic tool. Keywords: DNA microarray, glass platform, bubbling method, self-assambled monolayer

Reliability of laboratory tests of VSTOL and other long duration noises

Science.gov (United States)

Kryter, K. D.; Peeler, D. J.; Dobbs, M. E.; Lukas, J. S.

1974-01-01

Paired-comparison and magnitude estimations of the subjective noisiness or unacceptability of noise from fixed wing jet aircraft and simulated noise of VSTOL aircraft were obtained from groups of subjects given different instructions. These results suggest that VSTOL noises can be evaluated in terms of their noisiness or unwantedness to people with reasonable accuracy by units of the physical measures designated as PNdBM, with or without tone corrections, and dBD sub 2. Also, that consideration should be given to the use of D sub 2 as an overall frequency weighting function for sound level meters instead of the presently available A weighting. Two new units of noise measurement, PLdB and dB(E), used for predicting subjective noisiness, were found to be less accurate than PNdBM or dBD sub 2 in this regard.

Science Bubbles

DEFF Research Database (Denmark)

Hendricks, Vincent Fella; Pedersen, David Budtz

2013-01-01

Much like the trade and trait sof bubbles in financial markets,similar bubbles appear on the science market. When economic bubbles burst, the drop in prices causes the crash of unsustainable investments leading to an investor confidence crisis possibly followed by a financial panic. But when...... bubbles appear in science, truth and reliability are the first victims. This paper explores how fashions in research funding and research management may turn science into something like a bubble economy....

Bubble bursting at an interface

Science.gov (United States)

Kulkarni, Varun; Sajjad, Kumayl; Anand, Sushant; Fezzaa, Kamel

2017-11-01

Bubble bursting is crucial to understanding the life span of bubbles at an interface and more importantly the nature of interaction between the bulk liquid and the outside environment from the point of view of chemical and biological material transport. The dynamics of the bubble as it rises from inside the liquid bulk to its disappearance on the interface after bursting is an intriguing process, many aspects of which are still being explored. In our study, we make detailed high speed imaging measurements to examine carefully the hole initiation and growth in bursting bubbles that unearth some interesting features of the process. Previous analyses available in literature are revisited based on our novel experimental visualizations. Using a combination of experiments and theory we investigate the role of various forces during the rupturing process. This work aims to further our current knowledge of bubble dynamics at an interface with an aim of predicting better the bubble evolution from its growth to its eventual integration with the liquid bulk.

Effect of helium bubbles at grain boundaries on the fracture characteristics of high-density 238PuO2

International Nuclear Information System (INIS)

Sisson, R.D.; McDonell, W.R.

1976-01-01

Helium bubbles that formed at grain boundaries in high density (greater than 92 percent of theoretical) 238 PuO 2 shards did not affect the room temperature fracture behavior as observed by scanning electron microscopy. Fracture was predominantly by brittle transgranular cleavage with only infrequent intergranular failure observed. Pores (approximately 5 μm dia) that formed within the grains during the sintering process, rather than helium bubbles, initiated fractures. Helium bubbles were observed occasionally on the fracture surfaces of 20-month-old shards that had been heated to 1600 0 C for 8 h and subsequently crushed at room temperature. The average radius of these bubbles was approximately 1 μm. These bubbles were not interconnected, but were sometimes aligned in stringers

Measurement of the B$_{d}^{0}$ meson oscillation frequency

CERN Document Server

Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Fernández, D; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Korolko, I; Koutsenko, V F; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino

1996-01-01

Time-dependent \\Bd-\\Bbd\\ mixing is studied using 1.5 million hadronic Z decays collected by L3. Semileptonic B decays are selected by requiring at least one reconstructed lepton in both thrust hemispheres. Charge correlations between the tagged leptons are studied as a function of proper time. The proper time of the b-hadron decay is measured by reconstructing the production and decay vertices using a silicon microvertex detector. The measured \\Bd\\ meson oscillation frequency corresponds to a mass difference \\Dmd\\ between the two \\Bd\\ mass eigenstates of \\begin{displaymath} \\Dmd = \\left( 0.496 ^{+ 0.055}_{- 0.051}\\ \\mathrm{(stat)} \\pm{ 0.043}\\ \\mathrm{(syst)} \\right)\\ \\mathrm{ps}^{-1}. \\end{displaymath}

An investigation of bubble coalescence and post-rupture oscillation in non-ionic surfactant solutions using high-speed cinematography.

Science.gov (United States)

Bournival, G; Ata, S; Karakashev, S I; Jameson, G J

2014-01-15

Most processes involving bubbling in a liquid require small bubbles to maximise mass/energy transfer. A common method to prevent bubbles from coalescing is by the addition of surfactants. In order to get an insight into the coalescence process, capillary bubbles were observed using a high speed cinematography. Experiments were performed in solutions of 1-pentanol, 4-methyl-2-pentanol, tri(propylene glycol) methyl ether, and poly(propylene glycol) for which information such as the coalescence time and the deformation of the resultant bubble upon coalescence was extracted. It is shown in this study that the coalescence time increases with surfactant concentration until the appearance of a plateau. The increase in coalescence time with surfactant concentration could not be attributed only to surface elasticity. The oscillation of the resultant bubble was characterised by the damping of the oscillation. The results suggested that a minimum elasticity is required to achieve an increased damping and considerable diffusion has a detrimental effect on the dynamic response of the bubble, thereby reducing the damping. Copyright © 2013 Elsevier Inc. All rights reserved.

Characteristics of bubble plumes, bubble-plume bubbles and waves from wind-steepened wave breaking

NARCIS (Netherlands)

Leifer, I.; Caulliez, G.; Leeuw, G. de

2007-01-01

Observations of breaking waves, associated bubble plumes and bubble-plume size distributions were used to explore the coupled evolution of wave-breaking, wave properties and bubble-plume characteristics. Experiments were made in a large, freshwater, wind-wave channel with mechanical wind-steepened

Photochemistry of U(BH4)4 and U(BD4)4

International Nuclear Information System (INIS)

Paine, R.T.; Schonberg, P.R.; Light, R.W.; Danen, W.C.; Freund, S.M.

1979-01-01

U(BH 4 ) 4 and U(BD 4 ) 4 are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH 4 ) 3 , B 2 H 6 , H 2 , U(BD 4 ) 3 , B 2 D 6 and D 2 . Further, U(BD 4 ) 4 undergoes a related decomposition reaction under the influence of CO 2 laser irradiation at 924.97 cm -1 . (author)

Mesoporous hollow spheres from soap bubbling.

Science.gov (United States)

Yu, Xianglin; Liang, Fuxin; Liu, Jiguang; Lu, Yunfeng; Yang, Zhenzhong

2012-02-01

The smaller and more stable bubbles can be generated from the large parent bubbles by rupture. In the presence of a bubble blowing agent, hollow spheres can be prepared by bubbling a silica sol. Herein, the trapped gas inside the bubble acts as a template. When the porogen, i.e., other surfactant, is introduced, a mesostructured shell forms by the co-assembly with the silica sol during sol-gel process. Morphological evolution emphasizes the prerequisite of an intermediate interior gas flow rate and high exterior gas flow rate for hollow spheres. The method is valid for many compositions from inorganic, polymer to their composites. Copyright © 2011 Elsevier Inc. All rights reserved.

Electroweak bubble wall speed limit

Energy Technology Data Exchange (ETDEWEB)

Bödeker, Dietrich [Fakultät für Physik, Universität Bielefeld, 33501 Bielefeld (Germany); Moore, Guy D., E-mail: bodeker@physik.uni-bielefeld.de, E-mail: guymoore@ikp.physik.tu-darmstadt.de [Institut für Kernphysik, Technische Universität Darmstadt, Schlossgartenstraße 2, 64289 Darmstadt (Germany)

2017-05-01

In extensions of the Standard Model with extra scalars, the electroweak phase transition can be very strong, and the bubble walls can be highly relativistic. We revisit our previous argument that electroweak bubble walls can 'run away,' that is, achieve extreme ultrarelativistic velocities γ ∼ 10{sup 14}. We show that, when particles cross the bubble wall, they can emit transition radiation. Wall-frame soft processes, though suppressed by a power of the coupling α, have a significance enhanced by the γ-factor of the wall, limiting wall velocities to γ ∼ 1/α. Though the bubble walls can move at almost the speed of light, they carry an infinitesimal share of the plasma's energy.

High level expression of human epithelial β-defensins (hBD-1, 2 and 3 in papillomavirus induced lesions

Directory of Open Access Journals (Sweden)

Chong Kong T

2006-09-01

Full Text Available Abstract Background Epithelial defensins including human β-defensins (hBDs and α-defensins (HDs are antimicrobial peptides that play important roles in the mucosal defense system. However, the role of defensins in papillomavirus induced epithelial lesions is unknown. Results Papilloma tissues were prospectively collected from 15 patients with recurrent respiratory papillomatosis (RRP and analyzed for defensins and chemokine IL-8 expression by quantitative, reverse-transcriptase polymerase chain reaction (RT-PCR assays. HBD-1, -2 and -3 mRNAs were detectable in papilloma samples from all RRP patients and the levels were higher than in normal oral mucosal tissues from healthy individuals. Immunohistochemical analysis showed that both hBD-1 and 2 were localized in the upper epithelial layers of papilloma tissues. Expression of hBD-2 and hBD-3 appeared to be correlated as indicated by scatter plot analysis (r = 0.837, p Conclusion Human β-defensins are upregulated in respiratory papillomas. This novel finding suggests that hBDs might contribute to innate and adaptive immune responses targeted against papillomavirus-induced epithelial lesions.

Vitamin B@d12@@ concentrations in Mandovi and Zuari estuaries

Digital Repository Service at National Institute of Oceanography (India)

De; Rajendran, A.

Bioassay method using @iCyclotella nana@@ (clone 13) was employed for the estimation of Vitamin B@d12@@ in Mandovi and Zuari estuaries. At the mouth of the Mandovi estuary, B@d12@@ concentration varied between 0.38 and 7.0 ng/l in surface water...

A physiological model of the interaction between tissue bubbles and the formation of blood-borne bubbles under decompression

International Nuclear Information System (INIS)

Chappell, M A; Payne, S J

2006-01-01

Under decompression, bubbles can form in the human body, and these can be found both within the body tissues and the bloodstream. Mathematical models for the growth of both types of bubbles have previously been presented, but they have not been coupled together. This work thus explores the interaction between the growth of tissue and blood-borne bubbles under decompression, specifically looking at the extent to which they compete for the common resource of inert gas held in solution in the tissues. The influence of tissue bubbles is found to be significant for densities as low as 10 ml -1 for tissues which are poorly perfused. However, the effects of formation of bubbles in the blood are not found until the density of bubble production sites reaches 10 6 ml -1 . From comparison of the model predictions with experimental evidence for bubbles produced in animals and man under decompression, it is concluded that the density of tissue bubbles is likely to have a significant effect on the number of bubbles produced in the blood. However, the density of nucleation sites in the blood is unlikely to be sufficiently high in humans for the formation of bubbles in the blood to have a significant impact on the growth of the bubbles in the tissue

Search for short-lived particles produced on nuclei with a heavy liquid mini bubble chamber

CERN Multimedia

2002-01-01

The aim of this experiment is to search for short-lived particles produced in hadronic interactions on nuclei with our high resolution heavy liquid mini bubble chamber BIBC, aiming to establish the cross-section for associated production in hadron-nucleus collisions, its $A$-dependence and an approximate value of the lifetime. The chamber will be operated at a bubble density of 290 bubbles/cm and with an apparent bubble size of 30 $\\mu$m in real space. In test runs at CERN we measured detection efficiencies which, together with simulations of $D\\bar{D}$ production and decay, lead to a sensitivity of 0.25 events/($\\mu$b/N) per day if the lifetime is of the order of $5\\times10^{-13}$s. A null result after 10 days running time would set an upper limit on the production cross section to $3 \\mu$b. \\\\ \\\\ In order to measure the momenta of charged decay products of short-lived particles, the bubble chamber will be placed 1.80 m upstream of the streamer chamber of the NA5 experiment (MPI). The geometrical acceptance ...

Search for Very High Energy Gamma Rays from the Northern $\\textit{Fermi}$ Bubble Region with HAWC

OpenAIRE

Abeysekara, A. U.; Albert, A.; Alfaro, R.; Alvarez, C.; Álvarez, J. D.; Arceo, R.; Arteaga-Velázquez, J. C.; Solares, H. A. Ayala; Barber, A. S.; Bautista-Elivar, N.; Becerril, A.; Belmont-Moreno, E.; BenZvi, S. Y.; Berley, D.; Braun, J.

2017-01-01

We present a search of very high energy gamma-ray emission from the Northern $\\textit{Fermi}$ Bubble region using data collected with the High Altitude Water Cherenkov (HAWC) gamma-ray observatory. The size of the data set is 290 days. No significant excess is observed in the Northern $\\textit{Fermi}$ Bubble region, hence upper limits above $1\\,\\text{TeV}$ are calculated. The upper limits are between $3\\times 10^{-7}\\,\\text{GeV}\\, \\text{cm}^{-2}\\, \\text{s}^{-1}\\,\\text{sr}^{-1}$ and $4\\times 1...

An investigation of Bd0 and Bs0 oscillation

Science.gov (United States)

Buskulic, D.; de Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Minard, M.-N.; Odier, P.; Pietrzyk, B.; Ariztizabal, F.; Comas, P.; Crespo, J. M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Gaitan, V.; Garrido, Ll.; Martinez, M.; Mattison, T.; Orteu, S.; Pacheco, A.; Padilla, C.; Pascual, A.; Creanza, D.; de Palma, M.; Farilla, A.; Iaselli, G.; Maggi, G.; Marinelli, N.; Natali, S.; Nuzzo, S.; Ranieri, A.; Raso, G.; Romano, F.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Zito, G.; Chai, Y.; Hu, H.; Huang, D.; Huang, X.; Lin, J.; Wang, T.; Xie, Y.; Xu, D.; Xu, R.; Zhang, J.; Zhang, L.; Zhao, W.; Bonvicini, G.; Boudreau, J.; Casper, D.; Drevermann, H.; Forty, R. W.; Ganis, G.; Gay, C.; Girone, M.; Hagelberg, R.; Harvey, J.; Hilgart, J.; Jacobsen, R.; Jost, B.; Knobloch, J.; Lehraus, I.; Maggi, M.; Markou, C.; Mato, P.; Meinhard, H.; Minten, A.; Miquel, R.; Moser, H.-G.; Palazzi, P.; Pater, J. R.; Perlas, J. A.; Perrodo, P.; Pusztaszeri, J.-F.; Ranjard, F.; Rolandi, L.; Rothberg, J.; Ruan, T.; Saich, M.; Schlatter, D.; Schmelling, M.; Sefkow, F.; Tejessy, W.; Tomalin, I. R.; Veenhof, R.; Wachsmuth, H.; Wasserbaech, S.; Wiedenmann, W.; Wildish, T.; Witzeling, W.; Wotschack, J.; Ajaltouni, Z.; Bardadin-Otwinowska, M.; Barres, A.; Boyer, C.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michael, B.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Saadi, F.; Fearnley, T.; Hansen, J. B.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Johnson, S. D.; Møllerud, R.; Nilsson, B. S.; Kyriakis, A.; Simopoulou, E.; Siotis, I.; Vayaki, A.; Zachariadou, K.; Badier, J.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Bourdon, P.; Fouque, G.; Passalacqua, L.; Rougé, A.; Rumpf, M.; Tanaka, R.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Veitch, E.; Focardi, E.; Moneta, L.; Parrini, G.; Corden, M.; Delfino, M.; Georgipoulos, C.; Jaffe, D. E.; Levinthal, D.; Antonelli, A.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Cerutti, F.; Chiarella, V.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Pepe-Altarelli, M.; Salomone, S.; Colrain, P.; Ten Have, I.; Knowles, I. G.; Lynch, J. G.; Maitland, W.; Morton, W. T.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Smith, M. G.; Thompson, A. S.; Thorn, S.; Turnbull, R. M.; Brandl, B.; Braun, O.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Maumary, Y.; Putzer, A.; Rensch, B.; Stahl, A.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Cattaneo, M.; Colling, D. J.; Dornan, P. J.; Hassard, J. F.; Lieske, N. M.; Moutoussi, A.; Nash, J.; Patton, S.; Payne, D. G.; Phillips, M. J.; San Martin, G.; Sedgbeer, J. K.; Wright, A. G.; Girtler, P.; Kuhn, D.; Rudolph, G.; Vogl, R.; Bowdery, C. K.; Brodbeck, T. J.; Finch, A. J.; Foster, F.; Hughes, G.; Jackson, D.; Keemer, N. R.; Nuttall, M.; Patel, A.; Sloan, T.; Snow, S. W.; Whelan, E. P.; Galla, A.; Greene, A. M.; Kleinknecht, K.; Raab, J.; Renk, B.; Sander, H.-G.; Schmidt, H.; Walther, S. M.; Wanke, R.; Wolf, B.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Calvet, D.; Carr, J.; Coyle, P.; Diaconu, C.; Drinkard, J.; Etienne, F.; Nicod, D.; Payre, P.; Roos, L.; Rousseau, D.; Schwemling, P.; Talby, M.; Adlung, S.; Assmann, R.; Bauer, C.; Blum, W.; Brown, D.; Cattaneo, P.; Dehning, B.; Dietl, H.; Dydak, F.; Frank, M.; Halley, A. W.; Jakobs, K.; Lauber, J.; Lütjens, G.; Lutz, G.; Männer, W.; Richter, R.; Schröder, J.; Schwarz, A. S.; Settles, R.; Seywerd, H.; Stierlin, U.; Stiegle, U.; St. Denis, R.; Wolf, G.; Alemany, R.; Boucrot, J.; Callot, O.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Janot, P.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Musolino, G.; Schune, M.-H.; Veillet, J.-J.; Videau, I.; Abbaneo, D.; Bagliesi, G.; Batignani, G.; Bottigli, U.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; Ciulli, V.; Dell'Orso, R.; Ferrante, I.; Fidecaro, F.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Mannelli, E. B.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Triggiani, G.; Valassi, A.; Vannini, C.; Venturi, A.; Verdini, P. G.; Walsh, J.; Betteridge, A. P.; Gao, Y.; Green, M. G.; Johnson, D. L.; March, P. V.; Medcalf, T.; Mir, Ll. M.; Quazi, I. S.; Strong, J. A.; Bertin, V.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Haywood, S.; Edward, M.; Norton, P. R.; Thompson, J. C.; Bloch-Devaux, B.; Colas, P.; Duarte, H.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Marx, B.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Si Mohand, D.; Vallage, B.; Johnson, R. P.; Litke, A. M.; Taylor, G.; Wear, J.; Babbage, W.; Booth, C. N.; Buttar, C.; Cartwright, S.; Combley, F.; Dawson, I.; Thompson, L. F.; Barberio, E.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Lutters, G.; Rivera, F.; Schäfer, U.; Smolik, L.; Bosisio, L.; Della Marina, R.; Giannini, G.; Gobbo, B.; Pitis, L.; Ragusa, F.; Bellantoni, L.; Chen, W.; Chen, W.; Conway, J. S.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; Grahl, J.; Harton, J. L.; Hayes, O. J.; Nachtman, J. M.; Pan, Y. B.; Saadi, Y.; Schmitt, M.; Scott, I.; Sharma, V.; Shi, Z. H.; Turk, J. D.; Walsh, A. M.; Weber, F. V.; Sau Lan Wu; Wu, X.; Zheng, M.; Zobernig, G.; Aleph Collaboration

1994-02-01

B 0overlineB0 oscillation is studied using almost a million hadronic Z decays collected by the ALEPH experiment at LEP. Events are selected with two leptons present, on opposite sides of the event and with high transverse momentum. The leptons are expected to be dominantly from b decays; a topological vertexing technique is applied to measure the decay length of the b hadrons, and their momentum is determined using an energy-flow method. The fraction of events in which the leptons have the same charge is studied as a function of the measured decay time, and clear evidence is seen for the time-dependent nature of B d0overlineBd0 mixing. The frequency measured for the oscillation corresponds to a mass difference for the Bd0 mass eigenstates Δmd = (3.3 -0.4+0.5 ± 0.7) × 10 -4 eV/ c2. Allowing a second frequency component for the Bs0 a high value for Δms is favoured, leading to the limit Δms > 12 × 10 -4 eV/ c2 (95% CL), from which ( Δm/ Γ) s > 2.0 is derived.

Nuclear hBD-1 accumulation in malignant salivary gland tumours.

NARCIS (Netherlands)

Wenghoefer, M.H.; Pantelis, A.; Dommisch, H.; Gotz, W.; Reich, R.; Berge, S.J.; Martini, M.; Allam, J.P.; Jepsen, S.; Merkelbach-Bruse, S.; Fischer, H.P.; Novak, N.; Winter, J.

2008-01-01

BACKGROUND: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this

LA BD EN CLASSE DE FLE ? POURQUOI PAS !

Directory of Open Access Journals (Sweden)

Ana-Marina Tomescu

2009-11-01

Full Text Available Dans la présente étude nous allons essayer de démontrer que la BD représente certainement un phénomène de civilisation, qui donne la possibilité aux apprenants d’une langue étrangère de mieux comprendre un comportement culturel spécifique. Elle aide les apprenants à améliorer leur compétence socio-culturelle, parce qu’elle fait ressortir des éléments de civilisation pertinents, des clichés fréquemment rencontrés dans le monde francophone. La langue utilisée dans les BD est le français de tous les jours, l’accent est mis sur la conversation dans les plus diverses situations et à l’aide des registres de langue différents. Ce sont des motifs suffisants qui recommandent l’utilisation de la BD en classe de FLE, sans oublier de mentionner un atout essentiel : l’humour.

Validity and reliability of the Brief version of Quality of Life in Bipolar Disorder" (Bref QoL.BD) among Chinese bipolar patients.

Science.gov (United States)

Xiao, Lin; Gao, Yulin; Zhang, Lili; Chen, Peiyun; Sun, Xiaojia; Tang, Siyuan

2016-03-15

Previous literatures on quality of life (QoL) in bipolar disorder (BD) strongly suggested that a disease-specific QoL measure for patients with BD should be developed to evaluate QoL more specifically and reliably. To our knowledge, "Quality of Life in Bipolar Disorder" (QoL.BD) is the first and only questionnaire produced to specifically measure QoL in people with BD. In China, there is no disease-targeted measure available to specifically measure QoL in Chinese patients with BD. The aim of the study is to revise and validate the brief version of the QoL.BD (Bref QoL.BD ) into Chinese version. All the items of the Bref QoL.BD was translated into Chinese language, using the Brislin translation mode. The questionnaire was administered to a total sample of 231 subjects, including 101 BD patients and 130 healthy controls, to test the psychometric properties of Bref QoL.BD (e.g. internal consistency, retest reliability, content validity, item analysis, confirmatory factor analysis, criterion validity, convergent validity, discriminative validity and feasibility). The Chinese version of the Bref QoL.BD had very high internal consistency (Cronbach's alpha=0.815) and retest reliability (intraclass correlation coefficient (ICC )=0.808). Confirmatory factor analysis (CFA) validated the original one-factor structure. The direction and magnitude of correlations with 36-item Short-Form Health Survey (SF-36; rs= 0.313, Psize from only one tertiary care center. And BD patients enrolled were euthymic, excluding the acute BD patients. The Chinese version of the Bref QoL.BD is a feasible, reliable and valid tool for the assessment of QoL for Chinese BD patients. Copyright © 2015 Elsevier B.V. All rights reserved.

The Behavior of Micro Bubbles and Bubble Cluster in Ultrasound Field

Science.gov (United States)

Yoshizawa, Shin; Matsumoto, Yoichiro

2001-11-01

Ultrasound is widely applied in the clinical field today, such as ultrasound imaging, Extracorporeal Shock Wave Lithotripsy (ESWL) and so on. It is essential to take a real understanding of the dynamics of micro bubbles and bubble cluster in these applications. Thus we numerically simulate them in ultrasound field in this paper. In the numerical simulation, we consider the thermal behavior inside the bubble and the pressure wave phenomena in the bubble cluster in detail, namely, the evaporation and condensation of liquid at the bubble wall, heat transfer through the bubble wall, diffusion of non-condensable gas inside the bubble and the compressibility of liquid. Initial cluster radius is to 0.5[mm], bubble radius is 1.7[mm], void fraction is 0.1[ambient pressure is 101.3[kPa], temperature is 293[K] and the amplitude of ultrasound is 50[kPa]. We simulate bubble cluster in ultrasound field at various frequencies and we obtain the following conclusions. 1) The maximum pressure inside bubble cluster reaches 5[MPa] and this is much higher than that of a bubble. 2) Bubble cluster behaves like a rigid body acoustically when the frequency of ultrasound is much higher than its natural frequency.

Maternal deprivation exacerbates the response to a high fat diet in a sexually dimorphic manner.

Directory of Open Access Journals (Sweden)

Virginia Mela

Full Text Available Maternal deprivation (MD during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours during the neonatal period reduces body weight throughout life when the animals are maintained on a normal diet. However, little information is available regarding how this early stress affects the response to increased metabolic challenges during postnatal life. We hypothesized that MD modifies the response to a high fat diet (HFD and that this response differs between males and females. To address this question, both male and female Wistar rats were maternally deprived for 24 hours starting on the morning of postnatal day (PND 9. Upon weaning on PND22 half of each group received a control diet (CD and the other half HFD. MD rats of both sexes had significantly reduced accumulated food intake and weight gain compared to controls when raised on the CD. In contrast, when maintained on a HFD energy intake and weight gain did not differ between control and MD rats of either sex. However, high fat intake induced hyperleptinemia in MD rats as early as PND35, but not until PND85 in control males and control females did not become hyperleptinemic on the HFD even at PND102. High fat intake stimulated hypothalamic inflammatory markers in both male and female rats that had been exposed to MD, but not in controls. Reduced insulin sensitivity was observed only in MD males on the HFD. These results indicate that MD modifies the metabolic response to HFD intake, with this response being different between males and females. Thus, the development of obesity and secondary complications in response to high fat intake depends on numerous factors.

Macroporous 'bubble' graphene film via template-directed ordered-assembly for high rate supercapacitors.

Science.gov (United States)

Chen, Cheng-Meng; Zhang, Qiang; Huang, Chun-Hsien; Zhao, Xiao-Chen; Zhang, Bing-Sen; Kong, Qing-Qiang; Wang, Mao-Zhang; Yang, Yong-Gang; Cai, Rong; Sheng Su, Dang

2012-07-21

A three-dimensional bubble graphene film, with controllable and uniform macropores and tailorable microstructure, was fabricated by a facile hard templating strategy and exhibit extraordinary electrochemical capacitance with high rate capability (1.0 V s(-1)).

Fama on Bubbles

DEFF Research Database (Denmark)

Engsted, Tom

2016-01-01

While Eugene Fama has repeatedly expressed his discontent with the notion of an “irrational bubble,” he has never publicly expressed his opinion on “rational bubbles.” On empirical grounds Fama rejects bubbles by referring to the lack of reliable evidence that price declines are predictable....... However, this argument cannot be used to rule out rational bubbles because such bubbles do not necessarily imply return predictability, and return predictability of the kind documented by Fama does not rule out rational bubbles. On data samples that include the 1990s, there is evidence of an explosive...... component in stock market valuation ratios, consistent with a rational bubble....

Pinch-off Scaling Law of Soap Bubbles

Science.gov (United States)

Davidson, John; Ryu, Sangjin

2014-11-01

Three common interfacial phenomena that occur daily are liquid drops in gas, gas bubbles in liquid and thin-film bubbles. One aspect that has been studied for these phenomena is the formation or pinch-off of the drop/bubble from the liquid/gas threads. In contrast to the formation of liquid drops in gas and gas bubbles in liquid, thin-film bubble pinch-off has not been well documented. Having thin-film interfaces may alter the pinch-off process due to the limiting factor of the film thickness. We observed the pinch-off of one common thin-film bubble, soap bubbles, in order to characterize its pinch-off behavior. We achieved this by constructing an experimental model replicating the process of a human producing soap bubbles. Using high-speed videography and image processing, we determined that the minimal neck radius scaled with the time left till pinch-off, and that the scaling law exponent was 2/3, similar to that of liquid drops in gas.

Optical measurement of bubbles: System design and application

NARCIS (Netherlands)

Leifer, I.; Leeuw, G.de; Cohen, L.H.

2003-01-01

Affordable high quality charge-coupled device (CCD) video cameras and image processing software are powerful tools for bubble measurements. Because of the wide variation between bubble populations, different bubble measurement systems (BMSs) are required depending upon the application. Two BMSs are

The BD Onclarity HPV assay on SurePath collected samples meets the International Guidelines for Human Papillomavirus Test Requirements for Cervical Screening

DEFF Research Database (Denmark)

Ejegod, Ditte; Bottari, Fabio; Pedersen, Helle

2016-01-01

This study describes a validation of the BD Onclarity HPV (Onclarity) assay using the international guidelines for HPV test requirements for cervical cancer screening of women 30 years and above using Danish SurePath screening samples. The clinical specificity (0.90, 95% CI: 0.88-0.91) and sensit......This study describes a validation of the BD Onclarity HPV (Onclarity) assay using the international guidelines for HPV test requirements for cervical cancer screening of women 30 years and above using Danish SurePath screening samples. The clinical specificity (0.90, 95% CI: 0.......88-0.91) and sensitivity (0.97, 95% CI: 0.87-1.0) of the Onclarity assay were shown to be non-inferior to the reference assay (specificity 0.90, 95% CI: 0.88-0.92, sensitivity 0.98, 95% CI: 0.91-1.0). The intra-laboratory reproducibility of Onclarity was 97% with a lower confidence bound of 96% (kappa value: 0...

Interaction of a bubble and a bubble cluster in an ultrasonic field

International Nuclear Information System (INIS)

Wang Cheng-Hui; Cheng Jian-Chun

2013-01-01

Using an appropriate approximation, we have formulated the interacting equation of multi-bubble motion for a system of a single bubble and a spherical bubble cluster. The behavior of the bubbles is observed in coupled and uncoupled states. The oscillation of bubbles inside the cluster is in a coupled state. The numerical simulation demonstrates that the secondary Bjerknes force can be influenced by the number density, initial radius, distance, driving frequency, and amplitude of ultrasound. However, if a bubble approaches a bubble cluster of the same initial radii, coupled oscillation would be induced and a repulsive force is evoked, which may be the reason why the bubble cluster can exist steadily. With the increment of the number density of the bubble cluster, a secondary Bjerknes force acting on the bubbles inside the cluster decreases due to the strong suppression of the coupled bubbles. It is shown that there may be an optimal number density for a bubble cluster which can generate an optimal cavitation effect in liquid for a stable driving ultrasound. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

Effects of Gas Dynamics on Rapidly Collapsing Bubbles

OpenAIRE

Bauman, Spenser; Fomitchev-Zamilov, Max

2013-01-01

The dynamics of rapidly collapsing bubbles are of great interest due to the high degree of energy focusing that occurs withing the bubble. Molecular dynamics provides a way to model the interior of the bubble and couple the gas dynamics with the equations governing the bubble wall. While much theoretical work has been done to understand how a bubble will respond to an external force, the internal dynamics of the gas system are usually simplified greatly in such treatments. This paper shows ho...

Highly efficient decolorization of Malachite Green by a novel Micrococcus sp. strain BD15.

Science.gov (United States)

Du, Lin-Na; Zhao, Ming; Li, Gang; Zhao, Xiao-Ping; Zhao, Yu-Hua

2011-08-01

Malachite Green (MG) is used for a variety of applications but is also known to be carcinogenic and mutagenic. In this study, a novel Micrococcus sp. (strain BD15) was observed to efficiently decolorize MG. The purposes of this study were to explore the optimal conditions for decolorization and to evaluate the potential use of this strain for MG decolorization. Optical microscope and UV-visible analyses were carried out to determine whether the decolorization was due to biosorption or biodegradation. A Plackett-Burman design was employed to investigate the effect of various parameters on decolorization, and response surface methodology was then used to explore the optimal decolorization conditions. Kinetics analysis and antimicrobial activity tests were also performed. The results indicated that the decolorization by the strain was mainly due to biodegradation. Concentrations of MG, urea, and yeast extract and inoculum size had significantly positive effects on MG decolorization, while concentrations of CuCl(2) and MgCl(2), and temperature had significantly negative effects. The interaction between different parameters could significantly affect decolorization, and the optimal conditions for decolorization were 1.0 g/L urea, 0.9 g/L yeast extract, 100 mg/L MG, 0.1 g/L inoculums (dry weight), and incubation at 25.2°C. Under the optimal conditions, 96.9% of MG was removed by the strain within 1 h, which represents highly efficient microbial decolorization. Moreover, the kinetic data for decolorization fit a second-order model well, and the strain showed a good MG detoxification capability. Based on the results of this study, we propose Micrococcus sp. strain BD15 as an excellent candidate strain for MG removal from wastewater.

Measurement of pressure on a surface using bubble acoustic resonances

International Nuclear Information System (INIS)

Aldham, Ben; Manasseh, Richard; Liffman, Kurt; Šutalo, Ilija D; Illesinghe, Suhith; Ooi, Andrew

2010-01-01

The frequency response of gas bubbles as a function of liquid ambient pressure was measured and compared with theory. A bubble size with equivalent spherical radius of 2.29 mm was used over a frequency range of 1000–1500 Hz. The ultimate aim is to develop an acoustic sensor that can measure static pressure and is sensitive to variations as small as a few kPa. The classical bubble resonance frequency is known to vary with ambient pressure. Experiments were conducted with a driven bubble in a pressurizable tank with a signal processing system designed to extract the resonant peak. Since the background response of the containing tank is significant, particularly near tank-modal resonances, it must be carefully removed from the bubble response signal. A dual-hydrophone method was developed to allow rapid and reliable real-time measurements. The expected pressure dependence was found. In order to obtain a reasonable match with theory, the classical theory was modified by the introduction of a 'mirror bubble' to account for the influence of a nearby surface. (technical design note)

Performance Tests for Bubble Blockage Device

International Nuclear Information System (INIS)

Ha, Kwang Soon; Wi, Kyung Jin; Park, Rae Joon; Wan, Han Seong

2014-01-01

Postulated severe core damage accidents have a high threat risk for the safety of human health and jeopardize the environment. Versatile measures have been suggested and applied to mitigate severe accidents in nuclear power plants. To improve the thermal margin for the severe accident measures in high-power reactors, engineered corium cooling systems involving boiling-induced two-phase natural circulation have been proposed for decay heat removal. A boiling-induced natural circulation flow is generated in a coolant path between a hot vessel wall and cold coolant reservoir. In general, it is possible for some bubbles to be entrained in the natural circulation loop. If some bubbles entrain in the liquid phase flow passage, flow instability may occur, that is, the natural circulation mass flow rate may be oscillated. A new device to block the entraining bubbles is proposed and verified using air-water test loop. To avoid bubbles entrained in the natural circulation flow loop, a new device was proposed and verified using an air-water test loop. The air injection and liquid circulation loop was prepared, and the tests for the bubble blockage devices were performed by varying the geometry and shape of the devices. The performance of the bubble blockage device was more effective as the area ratio of the inlet to the down-comer increased, and the device height decreased. If the device has a rim to generate a vortex zone, the bubbles will be most effectively blocked

Slowing down bubbles with sound

Science.gov (United States)

Poulain, Cedric; Dangla, Remie; Guinard, Marion

2009-11-01

We present experimental evidence that a bubble moving in a fluid in which a well-chosen acoustic noise is superimposed can be significantly slowed down even for moderate acoustic pressure. Through mean velocity measurements, we show that a condition for this effect to occur is for the acoustic noise spectrum to match or overlap the bubble's fundamental resonant mode. We render the bubble's oscillations and translational movements using high speed video. We show that radial oscillations (Rayleigh-Plesset type) have no effect on the mean velocity, while above a critical pressure, a parametric type instability (Faraday waves) is triggered and gives rise to nonlinear surface oscillations. We evidence that these surface waves are subharmonic and responsible for the bubble's drag increase. When the acoustic intensity is increased, Faraday modes interact and the strongly nonlinear oscillations behave randomly, leading to a random behavior of the bubble's trajectory and consequently to a higher slow down. Our observations may suggest new strategies for bubbly flow control, or two-phase microfluidic devices. It might also be applicable to other elastic objects, such as globules, cells or vesicles, for medical applications such as elasticity-based sorting.

Three-dimensional reacting shock–bubble interaction

NARCIS (Netherlands)

Diegelmann, Felix; Hickel, S.; Adams, Nikolaus A.

2017-01-01

We investigate a reacting shock–bubble interaction through three-dimensional numerical simulations with detailed chemistry. The convex shape of the bubble focuses the shock and generates regions of high pressure and temperature, which are sufficient to ignite the diluted stoichiometric

Sensitivity Analysis and Accuracy of a CFD-TFM Approach to Bubbling Bed Using Pressure Drop Fluctuations.

Science.gov (United States)

Tricomi, Leonardo; Melchiori, Tommaso; Chiaramonti, David; Boulet, Micaël; Lavoie, Jean Michel

2017-01-01

Based upon the two fluid model (TFM) theory, a CFD model was implemented to investigate a cold multiphase-fluidized bubbling bed reactor. The key variable used to characterize the fluid dynamic of the experimental system, and compare it to model predictions, was the time-pressure drop induced by the bubble motion across the bed. This time signal was then processed to obtain the power spectral density (PSD) distribution of pressure fluctuations. As an important aspect of this work, the effect of the sampling time scale on the empirical power spectral density (PSD) was investigated. A time scale of 40 s was found to be a good compromise ensuring both simulation performance and numerical validation consistency. The CFD model was first numerically verified by mesh refinement process, after what it was used to investigate the sensitivity with regards to minimum fluidization velocity (as a calibration point for drag law), restitution coefficient, and solid pressure term while assessing his accuracy in matching the empirical PSD. The 2D model provided a fair match with the empirical time-averaged pressure drop, the relating fluctuations amplitude, and the signal's energy computed as integral of the PSD. A 3D version of the TFM was also used and it improved the match with the empirical PSD in the very first part of the frequency spectrum.

Bubble systems

CERN Document Server

Avdeev, Alexander A

2016-01-01

This monograph presents a systematic analysis of bubble system mathematics, using the mechanics of two-phase systems in non-equilibrium as the scope of analysis. The author introduces the thermodynamic foundations of bubble systems, ranging from the fundamental starting points to current research challenges. This book addresses a range of topics, including description methods of multi-phase systems, boundary and initial conditions as well as coupling requirements at the phase boundary. Moreover, it presents a detailed study of the basic problems of bubble dynamics in a liquid mass: growth (dynamically and thermally controlled), collapse, bubble pulsations, bubble rise and breakup. Special emphasis is placed on bubble dynamics in turbulent flows. The analysis results are used to write integral equations governing the rate of vapor generation (condensation) in non-equilibrium flows, thus creating a basis for solving a number of practical problems. This book is the first to present a comprehensive theory of boil...

Effect of chloride substitution on the order–disorder transition in NaBH4 and Na11BD4

International Nuclear Information System (INIS)

Olsen, Jørn Eirik; Karen, Pavel; Sørby, Magnus H.; Hauback, Bjørn C.

2014-01-01

Graphical abstract: Interactions that order the BD 4 - tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na( 11 BD 4 ) 1−x Cl x solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH 4 ) 1−x Cl x and Na( 11 BD 4 ) 1−x Cl x is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na( 11 BD 4 ) 1−x Cl x for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na 11 BD 4 at room temperature and 8 K and Na( 11 BD 4 ) 1−x Cl x (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na 11 BD 4 (NaBH 4 ) and its solid solutions with NaCl, Na( 11 BD 4 ) 1−x Cl x , is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na 11 BD 4 , ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na( 11 BD 4 ) 1−x Cl x follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na 11 BD 4 ) at 8 K

Guillem Fabre, “Pus dels majors” (BdT 216.2; Id., “Hon mais vey, pus truep sordeyor” (BdT 216.1

Directory of Open Access Journals (Sweden)

Linda Paterson

2013-03-01

Full Text Available The historical circumstances of Guillem Fabre’s two surviving sirventes has given rise to widely divergent views. This essay builds on Parducci’s contextualisation of BdT 216.2 during the War of the Sicilian Vespers and the so-called Aragonese crusade by the French against Pere III of Aragon in 1284-1285. It argues that Guillem is likely to be referring to events say entre nos because Narbonne was the focal point of the gathering French army and preaching of the crusade. All other textual details are compatible with this period and best explained by this context. But while Parducci places the sirventes in May 1285, it must in fact have preceded the death of Martin IV on 29 March, since his speedily-appointed successor Honorius IV could not be blamed for not having preached a crusade against the heathen before the conflict degenerated into further atrocities. Furthermore a slightly earlier timing better explains the allusion to “the best-known man in the world”, the obvious candidate at this time being Charles of Anjou. Guillem probably composed BdT 216.2 during the build-up to war in 1284, before the death of Charles in January 1285, during the period of war preparations and propaganda speeches. It is also argued here that, pace Parducci, BdT 216.1 did not necessarily precede BdT 216.2.

Bernoulli Suction Effect on Soap Bubble Blowing?

Science.gov (United States)

Davidson, John; Ryu, Sangjin

2015-11-01

As a model system for thin-film bubble with two gas-liquid interfaces, we experimentally investigated the pinch-off of soap bubble blowing. Using the lab-built bubble blower and high-speed videography, we have found that the scaling law exponent of soap bubble pinch-off is 2/3, which is similar to that of soap film bridge. Because air flowed through the decreasing neck of soap film tube, we studied possible Bernoulli suction effect on soap bubble pinch-off by evaluating the Reynolds number of airflow. Image processing was utilized to calculate approximate volume of growing soap film tube and the volume flow rate of the airflow, and the Reynolds number was estimated to be 800-3200. This result suggests that soap bubbling may involve the Bernoulli suction effect.

Shock waves from non-spherically collapsing cavitation bubbles

Science.gov (United States)

Supponen, Outi; Obreschkow, Danail; Farhat, Mohamed

2017-11-01

Combining simultaneous high-speed imaging and hydrophone measurements, we uncover details of the multiple shock wave emission from laser-induced cavitation bubbles collapsing in a non-spherical way. For strongly deformed bubbles collapsing near a free surface, we identify the distinct shock waves caused by the jet impact onto the opposite bubble wall and by the individual collapses of the remaining bubble segments. The energy carried by each of these shocks depends on the level of bubble deformation, quantified by the anisotropy parameter ζ, the dimensionless equivalent of the Kelvin impulse. For jetting bubbles, at ζ water hammer as ph = 0.45 (ρc2 Δp) 1 / 2ζ-1 .

Measurements of fast neutrons by bubble detectors

Energy Technology Data Exchange (ETDEWEB)

Castillo, F.; Martinez, H. [Laboratorio de Espectroscopia, Instituto de Ciencias Fisicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 48-3, 62251, Cuernavaca Morelos (Mexico); Leal, B. [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-543, 04510, Ciudad Universitaria, Mexico D. F. (Mexico); Rangel, J. [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-543, 04510, Ciudad Universitaria, Mexico D. F (Mexico); Reyes, P. G. [Facultad de Ciencias, Universidad Autonoma del Estado de Mexico, Instituto Literario 100, Col. Centro, 50000, Toluca Estado de Mexico (Mexico)

2013-07-03

Neutron bubble detectors have been studied using Am-Be and D-D neuron sources, which give limited energy information. The Bubble Detector Spectrometer (BDS) have six different energy thresholds ranging from 10 KeV to 10 Mev. The number of bubbles obtained in each measurement is related to the dose (standardized response R) equivalent neutrons through sensitivity (b / {mu}Sv) and also with the neutron flux (neutrons per unit area) through a relationship that provided by the manufacturer. Bubble detectors were used with six different answers (0.11 b/ {mu}Sv, 0093 b/{mu}Sv, 0.14 b/{mu}Sv, 0.17 b/{mu}Sv, 0051 b/{mu}Sv). To test the response of the detectors (BDS) radiate a set of six of them with different energy threshold, with a source of Am-Be, placing them at a distance of one meter from it for a few minutes. Also, exposed to dense plasma focus Fuego Nuevo II (FN-II FPD) of ICN-UNAM, apparatus which produces fusion plasma, generating neutrons by nuclear reactions of neutrons whose energy emitting is 2.45 MeV. In this case the detectors were placed at a distance of 50 cm from the pinch at 90 Degree-Sign this was done for a certain number of shots. In both cases, the standard response is reported (Dose in {mu}Sv) for each of the six detectors representing an energy range, this response is given by the expression R{sub i}= B{sub i} / S{sub i} where B{sub i} is the number of bubbles formed in each and the detector sensitivity (S{sub i}) is given for each detector in (b / {mu}Sv). Also, reported for both cases, the detected neutron flux (n cm{sup -2}), by a given ratio and the response involves both standardized R, as the average cross section sigma. The results obtained have been compared with the spectrum of Am-Be source. From these measurements it can be concluded that with a combination of bubble detectors, with different responses is possible to measure the equivalent dose in a range of 10 to 100 {mu}Sv fields mixed neutron and gamma, and pulsed generated fusion

Bd on the beach: high prevalence of Batrachochytrium dendrobatidis in the lowland forests of Gorgona Island (Colombia, South America).

Science.gov (United States)

Flechas, Sandra Victoria; Sarmiento, Carolina; Amézquita, Adolfo

2012-09-01

The amphibian chytrid fungus, Batrachochytrium dendrobatidis, Bd, has been implicated in the decimation and extinction of many amphibian populations worldwide, especially at mid and high elevations. Recent studies have demonstrated the presence of the pathogen in the lowlands from Australia and Central America. We extend here its elevational range by demonstrating its presence at the sea level, in the lowland forests of Gorgona Island, off the Pacific coast of Colombia. We conducted two field surveys, separated by four years, and diagnosed Bd by performing polymerase chain reactions on swab samples from the skin of five amphibian species. All species, including the Critically Endangered Atelopus elegans, tested positive for the pathogen, with prevalences between 3.9 % in A. elegans (in 2010) and 52 % in Pristimantis achatinus. Clinical signs of chytridiomycosis were not detected in any species. To our knowledge, this is the first report of B. dendrobatidis in tropical lowlands at sea level, where temperatures may exceed optimal growth temperatures of this pathogen. This finding highlights the need to understand the mechanisms allowing the interaction between frogs and pathogen in lowland ecosystems.

HIGH-MASS STAR FORMATION TOWARD SOUTHERN INFRARED BUBBLE S10

Energy Technology Data Exchange (ETDEWEB)

Das, Swagat Ranjan; Tej, Anandmayee; Vig, Sarita [Indian Institute of Space Science and Technology, Trivandrum 695547 (India); Ghosh, Swarna K.; Ishwara Chandra, C. H., E-mail: swagat.12@iist.ac.in [National Centre For Radio Astrophysics, Pune 411007 (India)

2016-11-01

An investigation in radio and infrared wavelengths of two high-mass star-forming regions toward the southern Galactic bubble S10 is presented here. The two regions under study are associated with the broken bubble S10 and Extended Green Object, G345.99-0.02, respectively. Radio continuum emission mapped at 610 and 1280 MHz using the Giant Metrewave Radio Telescope, India, is detected toward both of the regions. These regions are estimated to be ionized by early-B- to late-O-type stars. Spitzer GLIMPSE mid-infrared data is used to identify young stellar objects (YSOs) associated with these regions. A Class-I/II-type source, with an estimated mass of 6.2  M {sub ⊙}, lies ∼7″ from the radio peak. Pixel-wise, modified blackbody fits to the thermal dust emission using Herschel far-infrared data is performed to construct dust temperature and column density maps. Eight clumps are detected in the two regions using the 250 μ m image. The masses and linear diameter of these range between ∼300–1600  M {sub ⊙} and 0.2–1.1 pc, respectively, which qualifies them as high-mass star-forming clumps. Modeling of the spectral energy distribution of these clumps indicates the presence of high luminosity, high accretion rate, massive YSOs possibly in the accelerating accretion phase. Furthermore, based on the radio and MIR morphology, the occurrence of a possible bow wave toward the likely ionizing star is explored.

Sticky bubbles

NARCIS (Netherlands)

Antoniuk, O.; Bos, van der A.; Driessen, T.W.; Es, van B.; Jeurissen, R.J.M.; Michler, D.; Reinten, H.; Schenker, M.; Snoeijer, J.H.; Srivastava, S.; Toschi, F.; Wijshoff, H.M.A.

2011-01-01

We discuss the physical forces that are required to remove an air bubble immersed in a liquid from a corner. This is relevant for inkjet printing technology, as the presence of air bubbles in the channels of a printhead perturbs the jetting of droplets. A simple strategy to remove the bubble is to

SOA-BD: Service Oriented Architecture for Biomedical Devices

Directory of Open Access Journals (Sweden)

João Marcos Teixeira Lacerda

2017-05-01

Full Text Available Introduction: The communication of information systems with biomedical devices has become complex not only due to the existence of several private communication protocols, but also to the immutable way that software is embedded into these devices. In this sense, this paper proposes a service-oriented architecture to access biomedical devices as a way to abstract the mechanisms of writing and reading data from these devices, thus contributing to enable the focus of the development team of biomedical software to be intended for its functional requirements, i.e. business rules relevant to the problem domain. Methods The SOA-BD architecture consists of five main components: A Web Service for transport and conversion of the device data, Communication Protocols to access the devices, Data Parsers to preprocess data, a Device Repository to store data and transmitted information and Error handling, for error handling of these information. For the development of SOA-BD, technologies such as the XML language and the Java programming language were used. Besides, Software Engineering concepts such as Design Patterns were also used. For the validation of this work, data has been collected from vital sign monitors in an Intensive Care Unit using HL7 standards. Results The tests obtained a difference of about only 1 second in terms of response time with the use of SOA-BD. Conclusion SOA-BD achieves important results such as the reduction on the access protocol complexity, the opportunity for treating patients over long distances, allowing easier development of monitoring applications and interoperability with biomedical devices from diverse manufacturers.

High Performance of N-Doped Graphene with Bubble-like Textures for Supercapacitors.

Science.gov (United States)

Zhang, Shuo; Sui, Lina; Kang, Hongquan; Dong, Hongzhou; Dong, Lifeng; Yu, Liyan

2018-02-01

Nitrogen-doped graphene (NG) with wrinkled and bubble-like texture is fabricated by a thermal treatment. Especially, a novel sonication-assisted pretreatment with nitric acid is used to further oxidize graphene oxide and its binding with melamine molecules. There are many bubble-like nanoflakes with a dimension of about 10 nm appeared on the undulated graphene nanosheets. The bubble-like texture provides more active sites for effective ion transport and reversible capacitive behavior. The specific surface area of NG (5.03 at% N) can reach up to 438.7 m 2 g -1 , and the NG electrode demonstrates high specific capacitance (481 F g -1 at 1 A g -1 , four times higher than reduced graphene oxide electrode (127.5 F g -1 )), superior cycle stability (the capacitance retention of 98.9% in 2 m KOH and 99.2% in 1 m H 2 SO 4 after 8000 cycles), and excellent energy density (42.8 Wh kg -1 at power density of 500 W kg -1 in 2 m KOH aqueous electrolyte). The results indicate the potential use of NG as graphene-based electrode material for energy storage devices. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Energy cascading by triple-bubble interactions via time-delayed control

International Nuclear Information System (INIS)

Lin, Yen-Liang; Chang, Chia-Ming; Tseng, Fan-Gang; Yang, I-Da; Chieng, Ching-Chang

2012-01-01

The triple-bubble interaction controlled by a precise time-delayed technique was investigated in detail with respect to different ignition times, heater spaces and sequential firing modes to promote efficient energy cascading and concentration. The target bubble, which was generated under a specific delay time with two auxiliary bubbles, can have a volume that is two or almost three times larger than that of a single bubble. This result overcomes the limitation of energy usage on an explosive microbubble under a constant heat flux. As the heater space decreases, stronger bubble–bubble interactions were obtained due to the hydrodynamic effect and the intensive pressure wave emission, resulting in highly enhancing and depressing bubble dynamics. Other interesting phenomena, such as bubble shifting, mushroom-shape bubble, rod-shape bubble and bubble extension among heaters, were also recorded by a high-speed phase-averaged stroboscopic technique, displaying special non-spherical bubble dynamics. Artificial manipulation of bubble behavior was further conducted in a two-level sequential firing process. Using various volumetric combinations, the adjustable multi-level fluid transportation can be realized by a digital time-delayed control. The above-mentioned information can be applied to not only the design and operation of inkjet printheads but also cavitation research and fluid pumping in microdevices. (paper)

Characterization of Bubble Size Distributions within a Bubble Column

OpenAIRE

Shahrouz Mohagheghian; Brian R. Elbing

2018-01-01

The current study experimentally examines bubble size distribution (BSD) within a bubble column and the associated characteristic length scales. Air was injected into a column of water via a single injection tube. The column diameter (63–102 mm), injection tube diameter (0.8–1.6 mm) and superficial gas velocity (1.4–55 mm/s) were varied. Large samples (up to 54,000 bubbles) of bubble sizes measured via 2D imaging were used to produce probability density functions (PDFs). The PDFs were used to...

Creation of Single Chain of Nanoscale Skyrmion Bubbles with Record-high Temperature Stability in a Geometrically Confined Nanostripe

KAUST Repository

Hou, Zhipeng; Zhang, Qiang; Xu, Guizhou; Gong, Chen; Ding, Bei; Wang, Yue; Li, Hang; Liu, Enke; Xu, Feng; Zhang, Hongwei; Yao, Yuan; Wu, Guangheng; Zhang, Xixiang; Wang, Wenhong

2018-01-01

Nanoscale topologically nontrivial spin textures, such as magnetic skyrmions, have been identified as promising candidates for the transport and storage of information for spintronic applications, notably magnetic racetrack memory devices. The design and realization of a single skyrmion chain at room temperature (RT) and above in the low-dimensional nanostructures are of great importance for future practical applications. Here, we report the creation of a single skyrmion bubble chain in a geometrically confined Fe3Sn2 nanostripe with a width comparable to the featured size of a skyrmion bubble. Systematic investigations on the thermal stability have revealed that the single chain of skyrmion bubbles can keep stable at temperatures varying from RT up to a record-high temperature of 630 K. This extreme stability can be ascribed to the weak temperature-dependent magnetic anisotropy and the formation of edge states at the boundaries of the nanostripes. The realization of the highly stable skyrmion bubble chain in a geometrically confined nanostructure is a very important step toward the application of skyrmion-based spintronic devices.

Creation of Single Chain of Nanoscale Skyrmion Bubbles with Record-high Temperature Stability in a Geometrically Confined Nanostripe

KAUST Repository

Hou, Zhipeng

2018-01-04

Nanoscale topologically nontrivial spin textures, such as magnetic skyrmions, have been identified as promising candidates for the transport and storage of information for spintronic applications, notably magnetic racetrack memory devices. The design and realization of a single skyrmion chain at room temperature (RT) and above in the low-dimensional nanostructures are of great importance for future practical applications. Here, we report the creation of a single skyrmion bubble chain in a geometrically confined Fe3Sn2 nanostripe with a width comparable to the featured size of a skyrmion bubble. Systematic investigations on the thermal stability have revealed that the single chain of skyrmion bubbles can keep stable at temperatures varying from RT up to a record-high temperature of 630 K. This extreme stability can be ascribed to the weak temperature-dependent magnetic anisotropy and the formation of edge states at the boundaries of the nanostripes. The realization of the highly stable skyrmion bubble chain in a geometrically confined nanostructure is a very important step toward the application of skyrmion-based spintronic devices.

Microstreaming from Sessile Semicylindrical Bubbles

Science.gov (United States)

Hilgenfeldt, Sascha; Rallabandi, Bhargav; Guo, Lin; Wang, Cheng

2014-03-01

Powerful steady streaming flows result from the ultrasonic driving of microbubbles, in particular when these bubbles have semicylindrical cross section and are positioned in contact with a microfluidic channel wall. We have used this streaming in experiment to develop novel methods for trapping and sorting of microparticles by size, as well as for micromixing. Theoretically, we arrive at an analytical description of the streaming flow field through an asymptotic computation that, for the first time, reconciles the boundary layers around the bubble and along the substrate wall, and also takes into account the oscillation modes of the bubble. This approach gives insight into changes in the streaming pattern with bubble size and driving frequency, including a reversal of the flow direction at high frequencies with potentially useful applications. Present address: Mechanical and Aerospace Engineering, Missouri S &T.

Detection of Mycobacterium chelonae, Mycobacterium abscessus Group, and Mycobacterium fortuitum Complex by a Multiplex Real-Time PCR Directly from Clinical Samples Using the BD MAX System.

Science.gov (United States)

Rocchetti, Talita T; Silbert, Suzane; Gostnell, Alicia; Kubasek, Carly; Campos Pignatari, Antonio C; Widen, Raymond

2017-03-01

A new multiplex PCR test was designed to detect Mycobacterium chelonae, Mycobacterium abscessus group, and Mycobacterium fortuitum complex on the BD MAX System. A total of 197 clinical samples previously submitted for mycobacterial culture were tested using the new protocol. Samples were first treated with proteinase K, and then each sample was inoculated into the BD MAX Sample Buffer Tube. Extraction and multiplex PCR were performed by the BD MAX System, using the BD MAX ExK TNA-3 extraction kit and BD TNA Master Mix, along with specific in-house designed primers and probes for each target. The limit of detection of each target, as well as specificity, was evaluated. Of 197 clinical samples included in this study, 133 were positive and 60 were negative for mycobacteria by culture, and another 4 negative samples were spiked with M. chelonae ATCC 35752. The new multiplex PCR on the BD MAX had 97% concordant results with culture for M. abscessus group detection, 99% for M. chelonae, and 100% for M. fortuitum complex. The new multiplex PCR test performed on the BD MAX System proved to be a sensitive and specific test to detect M. chelonae, M. abscessus group, and M. fortuitum complex by real-time PCR on an automated sample-in results-out platform. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Rational equity bubbles

OpenAIRE

Zhou, Ge

2012-01-01

This paper discusses the existence of a bubble in the pricing of an asset that pays positive dividends. I show that rational bubbles can exist in a growing economy. The existence of bubbles depends on the relative magnitudes of risk aversion to consumption and to wealth. Furthermore, I examine how an exogenous shock in technology might trigger bubbles.

Bubble behaviour and mean diameter in subcooled flow boiling

Energy Technology Data Exchange (ETDEWEB)

Zeitoun, O.; Shoukri, M. [McMaster Univ., Hamilton, Ontario (Canada)

1995-09-01

Bubble behaviour and mean bubble diameter in subcooled upward flow boiling in a vertical annular channel were investigated under low pressure and mass flux conditions. A high speed video system was used to visualize the subcooled flow boiling phenomenon. The high speed photographic results indicated that, contrary to the common understanding, bubbles tend to detach from the heating surface upstream of the net vapour generation point. Digital image processing technique was used to measure the mean bubble diameter along the subcooled flow boiling region. Data on the axial area-averaged void fraction distributions were also obtained using a single beam gamma densitometer. Effects of the liquid subcooling, applied heat flux and mass flux on the mean bubble size were investigated. A correlation for the mean bubble diameter as a function of the local subcooling, heat flux and mass flux was obtained.

Gas Bubble Dynamics under Mechanical Vibrations

Science.gov (United States)

Mohagheghian, Shahrouz; Elbing, Brian

2017-11-01

The scientific community has a limited understanding of the bubble dynamics under mechanical oscillations due to over simplification of Navier-Stockes equation by neglecting the shear stress tensor and not accounting for body forces when calculating the acoustic radiation force. The current work experimental investigates bubble dynamics under mechanical vibration and resulting acoustic field by measuring the bubble size and velocity using high-speed imaging. The experimental setup consists of a custom-designed shaker table, cast acrylic bubble column, compressed air injection manifold and an optical imaging system. The mechanical vibrations resulted in accelerations between 0.25 to 10 times gravitational acceleration corresponding to frequency and amplitude range of 8 - 22Hz and 1 - 10mm respectively. Throughout testing the void fraction was limited to <5%. The bubble size is larger than resonance size and smaller than acoustic wavelength. The amplitude of acoustic pressure wave was estimated using the definition of Bjerknes force in combination with Rayleigh-Plesset equation. Physical behavior of the system was capture and classified. Bubble size, velocity as well as size and spatial distribution will be presented.

High Throughput Preparation of Aligned Nanofibers Using an Improved Bubble-Electrospinning

Directory of Open Access Journals (Sweden)

Liang Yu

2017-11-01

Full Text Available An improved bubble-electrospinning, consisting of a cone shaped air nozzle, a copper solution reservoir connected directly to the power generator, and a high speed rotating copper wire drum as a collector, was presented successfully to obtain high throughput preparation of aligned nanofibers. The influences of drum rotation speed on morphology and properties of obtained nanofibers were explored and researched. The results showed that the alignment degree, diameter distribution, and properties of nanofibers were improved with the increase of the drum rotation speed.

Three-Dimensional Reconstruction of a Gas Bubble Trajectory in Liquid

Directory of Open Access Journals (Sweden)

Augustyniak Jakub

2014-01-01

Full Text Available The identification of the shape of the bubble trajectory is crucial for understanding the mechanism of bubble motion in liquid. In the paper it has been presented the technique of 3D bubble trajectory reconstruction using a single high speed camera and the system of mirrors. In the experiment a glass tank filled with distilled water was used. The nozzle through which the bubbles were generated was placed in the centre of the tank. The movement of the bubbles was recorded with a high speed camera, the Phantom v1610 at a 600 fps. The techniques of image analysis has been applied to determine the coordinates of mass centre of each bubble image. The 3D trajectory of bubble can be obtained by using triangulation methods. In the paper the measurement error of imaging computer tomography has been estimated. The maximum measurement error was equal to ±0,65 [mm]. Trajectories of subsequently departing bubbles were visualized.

BEBC, the Big European Bubble Chamber

CERN Multimedia

CERN PhotoLab

1971-01-01

The vessel of the Big European Bubble Chamber, BEBC, was installed at the beginning of the 1970s. The large stainless-steel vessel, measuring 3.7 metres in diameter and 4 metres in height, was filled with 35 cubic metres of liquid (hydrogen, deuterium or a neon-hydrogen mixture), whose sensitivity was regulated by means of a huge piston weighing 2 tonnes. During each expansion, the trajectories of the charged particles were marked by a trail of bubbles, where liquid reached boiling point as they passed through it. The first images were recorded in 1973 when BEBC, equipped with the largest superconducting magnet in service at the time, first received beam from the PS. In 1977, the bubble chamber was exposed to neutrino and hadron beams at higher energies of up to 450 GeV after the SPS came into operation. By the end of its active life in 1984, BEBC had delivered a total of 6.3 million photographs to 22 experiments devoted to neutrino or hadron physics. Around 600 scientists from some fifty laboratories through...

A method for bubble volume calculating in vertical two-phase flow

International Nuclear Information System (INIS)

Wang, H Y; Dong, F

2009-01-01

The movement of bubble is a basic subject in gas-liquid two-phase flow research. A method for calculating bubble volume which is one of the most important characters in bubble motion research was proposed. A suit of visualized experimental device was designed and set up. Single bubble rising in stagnant liquid in a rectangular tank was studied using the high-speed video system. Bubbles generated by four orifice with different diameter (1mm, 2mm, 3mm, 4mm) were recorded respectively. Sequences of recorded high-speed images were processed by digital image processing method, such as image noise remove, binary image transform, bubble filling, and so on. then, Several parameters could be obtained from the processed image. Bubble area, equivalent diameter, bubble velocity, bubble acceleration are all indispensable in bubble volume calculating. In order to get the force balance equation, forces that work on bubble along vertical direction, including drag force, virtual mass force, buoyancy, gravity and liquid thrust, were analyzed. Finally, the bubble volume formula could be derived from the force balance equation and bubble parameters. Examples were given to shown the computing process and results. Comparison of the bubble volume calculated by geomettic method and the present method have shown the superiority of the proposed method in this paper.

Experimental study of bubbly flow using image processing techniques

Energy Technology Data Exchange (ETDEWEB)

Fu, Yucheng, E-mail: ycfu@vt.edu; Liu, Yang, E-mail: liu130@vt.edu

2016-12-15

This paper presents an experimental study of bubbly flows at relatively high void fractions using an advanced image processing method. Bubble overlapping is a common problem in such flows and the past studies often treat the overlapping bubbles as a whole, which introduces considerable measurement uncertainties. In this study, a hybrid method combining intersection point detection and watershed segmentation is used to separate the overlapping bubbles. In order to reconstruct bubbles from separated segments, a systematic procedure is developed which can preserve more features captured in the raw image compared to the simple ellipse fitting method. The distributions of void fraction, interfacial area concentration, number density and velocity are obtained from the extracted bubble information. High-speed images of air-water bubbly flows are acquired and processed for eight test runs conducted in a 30 mm × 10 mm rectangular channel. The developed image processing scheme can effectively separate overlapping bubbles and the results compare well with the measurements by the gas flow meter and double-sensor conductivity probe. The development of flows in transverse and mainstream directions are analyzed and compared with the prediction made by the one-dimensional interfacial area transport equation (IATE) and the bubble number density transport equation.

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity.

Science.gov (United States)

Bailleul, Geoffrey; Kravtzoff, Amanda; Joulin-Giet, Alix; Lecaille, Fabien; Labas, Valérie; Meudal, Hervé; Loth, Karine; Teixeira-Gomes, Ana-Paula; Gilbert, Florence B; Coquet, Laurent; Jouenne, Thierry; Brömme, Dieter; Schouler, Catherine; Landon, Céline; Lalmanach, Gilles; Lalmanach, Anne-Christine

2016-01-01

Defensins are frontline peptides of mucosal immunity in the animal kingdom, including birds. Their resistance to proteolysis and their ensuing ability to maintain antimicrobial potential remains questionable and was therefore investigated. We have shown by bottom-up mass spectrometry analysis of protein extracts that both avian beta-defensins AvBD2 and AvBD7 were ubiquitously distributed along the chicken gut. Cathepsin B was found by immunoblotting in jejunum, ileum, caecum, and caecal tonsils, while cathepsins K, L, and S were merely identified in caecal tonsils. Hydrolysis product of AvBD2 and AvBD7 incubated with a panel of proteases was analysed by RP-HPLC, mass spectrometry and antimicrobial assays. AvBD2 and AvBD7 were resistant to serine proteases and to cathepsins D and H. Conversely cysteine cathepsins B, K, L, and S degraded AvBD2 and abolished its antibacterial activity. Only cathepsin K cleaved AvBD7 and released Ile4-AvBD7, a N-terminal truncated natural peptidoform of AvBD7 that displayed antibacterial activity. Besides the 3-stranded antiparallel beta-sheet typical of beta-defensins, structural analysis of AvBD7 by two-dimensional NMR spectroscopy highlighted the restricted accessibility of the C-terminus embedded by the N-terminal region and gave a formal evidence of a salt bridge (Asp9-Arg12) that could account for proteolysis resistance. The differential susceptibility of avian defensins to proteolysis opens intriguing questions about a distinctive role in the mucosal immunity against pathogen invasion.

Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery.

Science.gov (United States)

Kutlu, Munir Gunes; Zeid, Dana; Tumolo, Jessica M; Gould, Thomas J

2018-04-01

Adolescence is a period of high risk for the initiation of nicotine product usage and exposure to traumatic events. In parallel, nicotine exposure has been found to age-dependently modulate acquisition of contextual fear memories; however, it is unknown if adolescent nicotine exposure alters extinction of fear related memories. Age-related differences in sensitivity to the effects of nicotine on fear extinction could increase or decrease susceptibility to anxiety disorders. In this study, we examined the effects of acute nicotine administration on extinction and spontaneous recovery of contextual fear memories in pre-adolescent (PND 23), late adolescent (PND 38), and adult (PND 53) C57B6/J mice. Mice were first trained in a background contextual fear conditioning paradigm and given an intraperitoneal injection of one of four doses of nicotine (0.045, 0.09, 0.18, or 0.36mg/kg, freebase) prior to subsequent extinction or spontaneous recovery sessions. Results indicated that all acute nicotine doses impaired extinction of contextual fear in adult mice. Late adolescent mice exhibited impaired extinction of contextual fear only following higher doses of acute nicotine, and extinction of contextual fear was unaffected by acute nicotine exposure in pre-adolescent mice. Finally, acute nicotine exposure enhanced spontaneous recovery of fear memory, but only in adult mice. Overall, our results suggest that younger mice were less sensitive to nicotine's impairing effects on extinction of contextual fear and to nicotine's enhancing effects on spontaneous recovery of contextual fear memory. Copyright © 2017 Elsevier Inc. All rights reserved.

Saudi production capacity climbing to 10 million b/d

International Nuclear Information System (INIS)

Anon.

1994-01-01

Saudi Arabia this year is completing its expansion of production capacity and developing recent discoveries to enhance export flexibility. The 3 million b/d capacity expansion to 10 million b/d, announced in 1989, is on target for completion by year end 1994. Most of the effort involves restoration of mothballed production equipment and installation of several gas-oil separation plants (GOSPs) in existing fields. But Saudi Arabian Oil Co. (Saudi Aramco) also this year will start up production of extra-light oil from a new field in the central part of the kingdom. Start-up of Hawtah area production demonstrates success of an oil search Aramco began after receiving exclusive exploration rights to nearly all of Saudi Arabia's prospective area in 1986. From new fields and traditional producing areas, therefore, Saudi Arabia has the potential to expand production capacity beyond 10 million b/d. The paper describes the development of the extra capacity

Chaotic bubbling and nonstagnant foams.

Science.gov (United States)

Tufaile, Alberto; Sartorelli, José Carlos; Jeandet, Philippe; Liger-Belair, Gerard

2007-06-01

We present an experimental investigation of the agglomeration of bubbles obtained from a nozzle working in different bubbling regimes. This experiment consists of a continuous production of bubbles from a nozzle at the bottom of a liquid column, and these bubbles create a two-dimensional (2D) foam (or a bubble raft) at the top of this column. The bubbles can assemble in various dynamically stable arrangement, forming different kinds of foams in a liquid mixture of water and glycerol, with the effect that the bubble formation regimes influence the foam obtained from this agglomeration of bubbles. The average number of bubbles in the foam is related to the bubble formation frequency and the bubble mean lifetime. The periodic bubbling can generate regular or irregular foam, while a chaotic bubbling only generates irregular foam.

A bubble detection system for propellant filling pipeline

Energy Technology Data Exchange (ETDEWEB)

Wen, Wen; Zong, Guanghua; Bi, Shusheng [Robotics Institute, Beihang University, 100191 Beijing (China)

2014-06-15

This paper proposes a bubble detection system based on the ultrasound transmission method, mainly for probing high-speed bubbles in the satellite propellant filling pipeline. First, three common ultrasonic detection methods are compared and the ultrasound transmission method is used in this paper. Then, the ultrasound beam in a vertical pipe is investigated, suggesting that the width of the beam used for detection is usually smaller than the internal diameter of the pipe, which means that when bubbles move close to the pipe wall, they may escape from being detected. A special device is designed to solve this problem. It can generate the spiral flow to force all the bubbles to ascend along the central line of the pipe. In the end, experiments are implemented to evaluate the performance of this system. Bubbles of five different sizes are generated and detected. Experiment results show that the sizes and quantity of bubbles can be estimated by this system. Also, the bubbles of different radii can be distinguished from each other. The numerical relationship between the ultrasound attenuation and the bubble radius is acquired and it can be utilized for estimating the unknown bubble size and measuring the total bubble volume.

Raman Spectral Band Oscillations in Large Graphene Bubbles

Science.gov (United States)

Huang, Yuan; Wang, Xiao; Zhang, Xu; Chen, Xianjue; Li, Baowen; Wang, Bin; Huang, Ming; Zhu, Chongyang; Zhang, Xuewei; Bacsa, Wolfgang S.; Ding, Feng; Ruoff, Rodney S.

2018-05-01

Raman spectra of large graphene bubbles showed size-dependent oscillations in spectral intensity and frequency, which originate from optical standing waves formed in the vicinity of the graphene surface. At a high laser power, local heating can lead to oscillations in the Raman frequency and also create a temperature gradient in the bubble. Based on Raman data, the temperature distribution within the graphene bubble was calculated, and it is shown that the heating effect of the laser is reduced when moving from the center of a bubble to its edge. By studying graphene bubbles, both the thermal conductivity and chemical reactivity of graphene were assessed. When exposed to hydrogen plasma, areas with bubbles are found to be more reactive than flat graphene.

Shear-induced Bubble Coalescence in Rhyolitic Melts with Low Vesicularity

Science.gov (United States)

Okumura, S.; Nakamura, M.; Tsuchiyama, A.

2006-12-01

Development of bubble structure during magma ascent controls the dynamics of volcanic eruption, because the bubble structure influences the magma rheology and permeability, and hence magma degassing. In the flowing magmas, the bubble structure is expected to be changed by shear, as pointed out by some previous studies based on geological observations. However, the development of bubble structure has been experimentally studied only in the isostatic magmas. We have experimentally demonstrated for the first time, the shear-induced development of number density, size and shape of bubbles in a rhyolitic melt. The deformation experiments were performed by using an externally heated, piston-cylinder type apparatus with a rotational piston. At 975°C, natural obsidian (initial water content of 0.5 wt%) having cylindrical shape (ca. 4.7 mm in diameter and 5 mm in length) was vesiculated in the graphite container (ca. 5 and 9 mm in the inner and the outer diameters, respectively, and 5 mm in length), and the vesiculated samples were twisted at various rotational speeds up to 1 rpm. The number density, size and shape of bubbles in the quenched samples were then measured by using the X-ray computed tomography. The size distribution of bubbles shows that the number of larger bubbles increases with the rotational speed and at the outer zone of the samples at which the shear rate is high. In the high shear rate zone, the magnitude of bubble deformation is large. The 3D images of large bubbles clearly indicate that they were formed by coalescence. These results indicate that the degree of bubble coalescence is enhanced with the shear rate. The experimental results also demonstrated that the coalescence of bubbles occur even at low vesicularity (ca. 20 vol.%). Because the shear rate induced in this study (in the order of 0.01 1/s) seems to be produced for magmas ascending in a volcanic conduit, we propose the possibility that the vesiculated magmas undergo bubble coalescence at a

Field-reversed bubble in deep plasma channels for high quality electron acceleration

CERN Document Server

Pukhov, A; Tueckmantel, T; Thomas, J; Yu, I; Kostyukov, Yu

2014-01-01

We study hollow plasma channels with smooth boundaries for laser-driven electron acceleration in the bubble regime. Contrary to the uniform plasma case, the laser forms no optical shock and no etching at the front. This increases the effective bubble phase velocity and energy gain. The longitudinal field has a plateau that allows for mono-energetic acceleration. We observe as low as 10−3 r.m.s. relative witness beam energy uncertainty in each cross-section and 0.3% total energy spread. By varying plasma density profile inside a deep channel, the bubble fields can be adjusted to balance the laser depletion and dephasing lengths. Bubble scaling laws for the deep channel are derived. Ultra-short pancake-like laser pulses lead to the highest energies of accelerated electrons per Joule of laser pulse energy.

Behavioral approach system sensitivity and risk taking interact to predict left-frontal EEG asymmetry.

Science.gov (United States)

Black, Chelsea L; Goldstein, Kim E; LaBelle, Denise R; Brown, Christopher W; Harmon-Jones, Eddie; Abramson, Lyn Y; Alloy, Lauren B

2014-09-01

The Behavioral Approach System (BAS) hypersensitivity theory of bipolar disorder (BD; Alloy & Abramson, 2010; Depue & Iacono, 1989) suggests that hyperreactivity in the BAS results in the extreme fluctuations of mood characteristic of BD. In addition to risk conferred by BAS hypersensitivity, cognitive and personality variables may play a role in determining risk. We evaluated relationships among BAS sensitivity, risk taking, and an electrophysiological correlate of approach motivation, relative left-frontal electroencephalography (EEG) asymmetry. BAS sensitivity moderated the relationship between risk taking and EEG asymmetry. More specifically, individuals who were high in BAS sensitivity showed left-frontal EEG asymmetry regardless of their level of risk-taking behavior. However, among individuals who were moderate in BAS sensitivity, risk taking was positively associated with asymmetry. These findings suggest that cognitive and personality correlates of bipolar risk may evidence unique contributions to a neural measure of trait-approach motivation. Clinical implications of these findings are discussed. Copyright © 2014. Published by Elsevier Ltd.

The formation of soap bubbles created by blowing on soap films

Science.gov (United States)

Salkin, Louis; Schmit, Alexandre; Panizza, Pascal; Courbin, Laurent

2015-11-01

Using either circular bubble wands or long-lasting vertically falling soap films having an adjustable steady state thickness, we study the formation of soap bubbles created when air is blown through a nozzle onto a soap film. We vary nozzle radius, film size, space between the film and nozzle, and gas density, and we measure the gas velocity threshold above which bubbles are generated. The response is sensitive to confinement, that is, the ratio between film and jet sizes, and dissipation in the turbulent gas jet which is a function of the distance from the nozzle to the film. We observe four different regimes that we rationalize by comparing the dynamic pressure of a jet on the film and the Laplace pressure needed to create the curved surface of a bubble.

Experimental Investigation of Large-Scale Bubbly Plumes

International Nuclear Information System (INIS)

Zboray, R.; Simiano, M.; De Cachard, F.

2004-01-01

Carefully planned and instrumented experiments under well-defined boundary conditions have been carried out on large-scale, isothermal, bubbly plumes. The data obtained is meant to validate newly developed, high-resolution numerical tools for 3D transient, two-phase flow modelling. Several measurement techniques have been utilised to collect data from the experiments: particle image velocimetry, optical probes, electromagnetic probes, and visualisation. Bubble and liquid velocity fields, void-fraction distributions, bubble size and interfacial-area-concentration distributions have all been measured in the plume region, as well as recirculation velocities in the surrounding pool. The results obtained from the different measurement techniques have been compared. In general, the two-phase flow data obtained from the different techniques are found to be consistent, and of high enough quality for validating numerical simulation tools for 3D bubbly flows. (author)

Experimental Investigation of Large-Scale Bubbly Plumes

Energy Technology Data Exchange (ETDEWEB)

Zboray, R.; Simiano, M.; De Cachard, F

2004-03-01

Carefully planned and instrumented experiments under well-defined boundary conditions have been carried out on large-scale, isothermal, bubbly plumes. The data obtained is meant to validate newly developed, high-resolution numerical tools for 3D transient, two-phase flow modelling. Several measurement techniques have been utilised to collect data from the experiments: particle image velocimetry, optical probes, electromagnetic probes, and visualisation. Bubble and liquid velocity fields, void-fraction distributions, bubble size and interfacial-area-concentration distributions have all been measured in the plume region, as well as recirculation velocities in the surrounding pool. The results obtained from the different measurement techniques have been compared. In general, the two-phase flow data obtained from the different techniques are found to be consistent, and of high enough quality for validating numerical simulation tools for 3D bubbly flows. (author)

Size-selective sorting in bubble streaming flows: Particle migration on fast time scales

Science.gov (United States)

Thameem, Raqeeb; Rallabandi, Bhargav; Hilgenfeldt, Sascha

2015-11-01

Steady streaming from ultrasonically driven microbubbles is an increasingly popular technique in microfluidics because such devices are easily manufactured and generate powerful and highly controllable flows. Combining streaming and Poiseuille transport flows allows for passive size-sensitive sorting at particle sizes and selectivities much smaller than the bubble radius. The crucial particle deflection and separation takes place over very small times (milliseconds) and length scales (20-30 microns) and can be rationalized using a simplified geometric mechanism. A quantitative theoretical description is achieved through the application of recent results on three-dimensional streaming flow field contributions. To develop a more fundamental understanding of the particle dynamics, we use high-speed photography of trajectories in polydisperse particle suspensions, recording the particle motion on the time scale of the bubble oscillation. Our data reveal the dependence of particle displacement on driving phase, particle size, oscillatory flow speed, and streaming speed. With this information, the effective repulsive force exerted by the bubble on the particle can be quantified, showing for the first time how fast, selective particle migration is effected in a streaming flow. We acknowledge support by the National Science Foundation under grant number CBET-1236141.

Comparison of cavitation bubbles evolution in viscous media

Directory of Open Access Journals (Sweden)

Jasikova Darina

2018-01-01

Full Text Available There have been tried many types of liquids with different ranges of viscosity values that have been tested to form a single cavitation bubble. The purpose of these experiments was to observe the behaviour of cavitation bubbles in media with different ranges of absorbance. The most of the method was based on spark to induced superheat limit of liquid. Here we used arrangement of the laser-induced breakdown (LIB method. There were described the set cavitation setting that affects the size bubble in media with different absorbance. We visualized the cavitation bubble with a 60 kHz high speed camera. We used here shadowgraphy setup for the bubble visualization. There were observed time development and bubble extinction in various media, where the size of the bubble in the silicone oil was extremely small, due to the absorbance size of silicon oil.

Bubble levitation and translation under single-bubble sonoluminescence conditions.

Science.gov (United States)

Matula, Thomas J

2003-08-01

Bubble levitation in an acoustic standing wave is re-examined for conditions relevant to single-bubble sonoluminescence. Unlike a previous examination [Matula et al., J. Acoust. Soc. Am. 102, 1522-1527 (1997)], the stable parameter space [Pa,R0] is accounted for in this realization. Forces such as the added mass force and drag are included, and the results are compared with a simple force balance that equates the Bjerknes force to the buoyancy force. Under normal sonoluminescence conditions, the comparison is quite favorable. A more complete accounting of the forces shows that a stably levitated bubble does undergo periodic translational motion. The asymmetries associated with translational motion are hypothesized to generate instabilities in the spherical shape of the bubble. A reduction in gravity results in reduced translational motion. It is hypothesized that such conditions may lead to increased light output from sonoluminescing bubbles.

Cavitation bubble nucleation induced by shock-bubble interaction in a gelatin gel

Science.gov (United States)

Oguri, Ryota; Ando, Keita

2018-05-01

An optical visualization technique is developed to study cavitation bubble nucleation that results from interaction between a laser-induced shock and a preexisting gas bubble in a 10 wt. % gelatin gel; images of the nucleated cavitation bubbles are captured and the cavitation inception pressure is determined based on Euler flow simulation. A spherical gas cavity is generated by focusing an infrared laser pulse into a gas-supersaturated gel and the size of the laser-generated bubble in mechanical equilibrium is tuned via mass transfer of the dissolved gas into the bubble. A spherical shock is then generated, through rapid expansion of plasma induced by the laser focusing, in the vicinity of the gas bubble. The shock-bubble interaction is recorded by a CCD camera with flash illumination of a nanosecond green laser pulse. The observation captures cavitation inception in the gel under tension that results from acoustic impedance mismatching at the bubble interface interacting with the shock. We measure the probability of cavitation inception from a series of the repeated experiments, by varying the bubble radius and the standoff distance. The threshold pressure is defined at the cavitation inception probability equal to one half and is calculated, through comparisons to Euler flow simulation, at -24.4 MPa. This threshold value is similar to that from shock-bubble interaction experiments using water, meaning that viscoelasticity of the 10 wt. % gelatin gel has a limited impact on bubble nucleation dynamics.

Luminescence from cavitation bubbles deformed in uniform pressure gradients

Science.gov (United States)

Supponen, Outi; Obreschkow, Danail; Kobel, Philippe; Farhat, Mohamed

2017-09-01

Presented here are observations that demonstrate how the deformation of millimetric cavitation bubbles by a uniform pressure gradient quenches single-collapse luminescence. Our innovative measurement system captures a broad luminescence spectrum (wavelength range, 300-900 nm) from the individual collapses of laser-induced bubbles in water. By varying the bubble size, driving pressure, and perceived gravity level aboard parabolic flights, we probed the limit from aspherical to highly spherical bubble collapses. Luminescence was detected for bubbles of maximum radii within the previously uncovered range, R0=1.5 -6 mm, for laser-induced bubbles. The relative luminescence energy was found to rapidly decrease as a function of the bubble asymmetry quantified by the anisotropy parameter ζ , which is the dimensionless equivalent of the Kelvin impulse. As established previously, ζ also dictates the characteristic parameters of bubble-driven microjets. The threshold of ζ beyond which no luminescence is observed in our experiment closely coincides with the threshold where the microjets visibly pierce the bubble and drive a vapor jet during the rebound. The individual fitted blackbody temperatures range between Tlum=7000 and Tlum=11 500 K but do not show any clear trend as a function of ζ . Time-resolved measurements using a high-speed photodetector disclose multiple luminescence events at each bubble collapse. The averaged full width at half-maximum of the pulse is found to scale with R0 and to range between 10 and 20 ns.

The KEK 1 m hydrogen bubble chamber

International Nuclear Information System (INIS)

Doi, Yoshikuni; Araoka, Osamu; Hayashi, Kohei; Hayashi, Yoshio; Hirabayashi, Hiromi.

1978-03-01

A medium size hydrogen bubble chamber has been constructed at the National Laboratory for High Energy Physics, KEK. The bubble chamber has been designed to be operated with a maximum rate of three times per half a second in every two second repetition time of the accelerator, by utilizing a hydraulic expansion system. The bubble chamber has a one meter diameter and a visible volume of about 280 l. A three-view stereo camera system is used for taking photographic pictures of the chamber. A 2 MW bubble chamber magnet is constructed. The main part of the bubble chamber vessel is supported by the magnet yoke. The magnet gives a maximum field of 18.4 kG at the centre of the fiducial volume of the chamber. The overall system of the KEK 1 m hydrogen bubble chamber facility is described in some detail. Some operational characteristics of the facility are also reported. (auth.)

Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound.

Science.gov (United States)

Brujan, E A; Ikeda, T; Matsumoto, Y

2005-10-21

The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, gamma, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at gamma = 1.55 and 1:3.5 at gamma = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at gamma = 1, to 0.162 MPa, at gamma = 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s(-1), at gamma = 1, to 36 m s(-1), at gamma = 1.55. For gamma < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound.

Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound

International Nuclear Information System (INIS)

Brujan, E A; Ikeda, T; Matsumoto, Y

2005-01-01

The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, γ, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at γ = 1.55 and 1:3.5 at γ = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at γ = 1, to 0.162 MPa, at γ 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s -1 , at γ = 1, to 36 m s -1 , at γ = 1.55. For γ < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound

Laboratory experiments on fragmentation of highly-viscous bubbly syrup

Science.gov (United States)

Kurihara, H.; Kameda, M.; Ichihara, M.

2006-12-01

Fragmentation of vesicular magma by rapid decompression is a key process in explosive eruptions. To determine the fragmentation criteria, we carried out laboratory experiments on magma fragmentation using analogous materials. We used commercial syrup as an analogous material of magma, because the viscosity was widely altered by adding or subtracting water contents in the syrup. We made the bubbly syrup by adding hydrogen peroxide with manganese oxide in the syrup. The amount of hydrogen peroxide is proportional to the gas volume fraction in the syrup. We measured the rheological properties of the syrup. Zero shear viscosity η was measured by a rotating viscometer and a fiber elongation technique. Glass transition temperature was measured by differential scanning calorimetry. The measured data indicated that the temperature dependence of viscosity was described well using Williams-Landel-Ferry (WLF) equation. The solid content of syrup alters the viscosity as well as the glass transition temperature, though it may hardly affect the rigidity μ, which was measured by ultrasonic test in our previous work. We used a pressurized vertical tube with a large vacuum vessel to apply the rapid decompression on the material. An acrylic container, filled with the bubbly syrup, was placed in the bottom of the pressurized tube. By rupturing the diaphragms inserted between the tube and the vacuum vessel, the bubbly syrup is rapidly decompressed due to expansion of the pressurized gas in the tube. A high-speed video camera was used to obtain sequential images of the materials. Pressure transducers were mounted on the sidewall of the tube and the bottom of the container. The initial pressure was varied from 1 MPa to 5 MPa. The gas-volume fraction of the syrup under pressure was fixed as 2 % to 20%. The viscosity varied from 105 Pa·s to 108 Pa·s. We successfully observed three principal behaviors using the present analogous material; brittle fragmentation, partial fracture and

Photothermally controlled Marangoni flow around a micro bubble

International Nuclear Information System (INIS)

Namura, Kyoko; Nakajima, Kaoru; Kimura, Kenji; Suzuki, Motofumi

2015-01-01

We have experimentally investigated the control of Marangoni flow around a micro bubble using photothermal conversion. Using a focused laser spot acting as a highly localized heat source on Au nanoparticles/dielectric/Ag mirror thin film enables us to create a micro bubble and to control the temperature gradient around the bubble at a micrometer scale. When we irradiate the laser next to the bubble, a strong main flow towards the bubble and two symmetric rotation flows on either side of it develop. The shape of this rotation flow shows a significant transformation depending on the relative position of the bubble and the laser spot. Using this controllable rotation flow, we have demonstrated sorting of the polystyrene spheres with diameters of 2 μm and 0.75 μm according to their size

Photothermally controlled Marangoni flow around a micro bubble

Science.gov (United States)

Namura, Kyoko; Nakajima, Kaoru; Kimura, Kenji; Suzuki, Motofumi

2015-01-01

We have experimentally investigated the control of Marangoni flow around a micro bubble using photothermal conversion. Using a focused laser spot acting as a highly localized heat source on Au nanoparticles/dielectric/Ag mirror thin film enables us to create a micro bubble and to control the temperature gradient around the bubble at a micrometer scale. When we irradiate the laser next to the bubble, a strong main flow towards the bubble and two symmetric rotation flows on either side of it develop. The shape of this rotation flow shows a significant transformation depending on the relative position of the bubble and the laser spot. Using this controllable rotation flow, we have demonstrated sorting of the polystyrene spheres with diameters of 2 μm and 0.75 μm according to their size.

Bubbling away

Energy Technology Data Exchange (ETDEWEB)

Anon.

1993-10-15

Bubble chambers may have almost vanished from the front line of physics research, but the vivid memory of their intricate and sometimes beautiful patterns of particle tracks lives on, and has greatly influenced the computer graphics of track reconstruction in today's big experiments. 'Seeing' an interaction makes it more understandable. Bubble chambers, with their big collaborations of physicists from many widely scattered research institutes, started another ball rolling. The groups formed are even now only surpassed in size by the big collaborations working on today's major detectors at colliding beam machines. From 14-16 July, about 130 physicists gathered at CERN to commemorate the 40th anniversary of the invention of the bubble chamber by Donald Glaser. The meeting, organized by Derek C. Colley from Birmingham, gave a comprehensive overview of bubble chamber contributions to physics, their challenging technology, and the usefulness of bubble chamber photographs in education, both for physics and the public at large. After opening remarks by CERN Director Carlo Rubbia, Donald Glaser began with a brief review of the work which led to his invention - there was much more to it than idly watching beer bubbles rise up the wall of the glass - before turning to his present line of research, biophysics, also very visually oriented.

Particle Transport and Size Sorting in Bubble Microstreaming Flow

Science.gov (United States)

Thameem, Raqeeb; Rallabandi, Bhargav; Wang, Cheng; Hilgenfeldt, Sascha

2014-11-01

Ultrasonic driving of sessile semicylindrical bubbles results in powerful steady streaming flows that are robust over a wide range of driving frequencies. In a microchannel, this flow field pattern can be fine-tuned to achieve size-sensitive sorting and trapping of particles at scales much smaller than the bubble itself; the sorting mechanism has been successfully described based on simple geometrical considerations. We investigate the sorting process in more detail, both experimentally (using new parameter variations that allow greater control over the sorting) and theoretically (incorporating the device geometry as well as the superimposed channel flow into an asymptotic theory). This results in optimized criteria for size sorting and a theoretical description that closely matches the particle behavior close to the bubble, the crucial region for size sorting.

Cavitation inception by the backscattering of pressure waves from a bubble interface

Energy Technology Data Exchange (ETDEWEB)

Takahira, Hiroyuki, E-mail: takahira@me.osakafu-u.ac.jp; Ogasawara, Toshiyuki, E-mail: oga@me.osakafu-u.ac.jp; Mori, Naoto, E-mail: su101064@edu.osakafu-u.ac.jp; Tanaka, Moe [Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai-shi, Osaka 599-8531 (Japan)

2015-10-28

The secondary cavitation that occurs by the backscattering of focused ultrasound from a primary cavitation bubble caused by the negative pressure part of the ultrasound (Maxwell, et al., 2011) might be useful for the energy exchange due to bubble oscillations in High Intensity Focused Ultrasound (HIFU). The present study is concerned with the cavitation inception by the backscattering of ultrasound from a bubble. In the present experiment, a laser-induced bubble which is generated by a pulsed focused laser beam with high intensity is utilized as a primary cavitation bubble. After generating the bubble, focused ultrasound is emitted to the bubble. The acoustic field and the bubble motion are observed with a high-speed video camera. It is confirmed that the secondary cavitation bubble clouds are generated by the backscattering from the laser-induced bubble. The growth of cavitation bubble clouds is analyzed with the image processing method. The experimental results show that the height and width of the bubble clouds grow in stepwise during their evolution. The direct numerical simulations are also conducted for the backscattering of incident pressure waves from a bubble in order to evaluate a pressure field near the bubble. It is shown that the ratio of a bubble collapse time t{sub 0} to a characteristic time of wave propagation t{sub S}, η = t{sub 0}/t{sub s}, is an important determinant for generating negative pressure region by backscattering. The minimum pressure location by the backscattering in simulations is in good agreement with the experiment.

Bubble Dynamics in Laser Lithotripsy

International Nuclear Information System (INIS)

Mohammadzadeh, Milad; Mercado, Julian Martinez; Ohl, Claus-Dieter

2015-01-01

Laser lithotripsy is a medical procedure for fragmentation of urinary stones with a fiber guided laser pulse of several hundred microseconds long. Using high-speed photography, we present an in-vitro study of bubble dynamics and stone motion induced by Ho:YAG laser lithotripsy. The experiments reveal that detectable stone motion starts only after the bubble collapse, which we relate with the collapse-induced liquid flow. Additionally, we model the bubble formation and dynamics using a set of 2D Rayleigh-Plesset equations with the measured laser pulse profile as an input. The aim is to reduce stone motion through modification of the temporal laser pulse profile, which affects the collapse scenario and consequently the remnant liquid motion. (paper)

Empirical regularities in the excitation cross-section behavior of the lead atom (transitions from energy levels of 6pnd configurations)

Science.gov (United States)

Smirnov, Yu M.

2018-03-01

Electron-impact excitation of lead atom levels belonging to 6pnd configurations has been studied in experiment. One hundred two excitation cross-sections have been measured at an incident electron energy of 50 eV. Eleven optical excitation functions (OEFs) have been recorded in the exciting electron energy range of E = 0-200 eV. The resulting findings were used to study the excitation cross-sections dependence on the principal quantum number of upper levels for thirteen PbI spectral series.

Effect of bubble interface parameters on predicted of bubble departure diameter in a narrow channel

International Nuclear Information System (INIS)

Xu Jianjun; Xie Tianzhou; Zhou Wenbin; Chen Bingde; Huang Yanping

2014-01-01

The predicted model on the bubble departure diameter in a narrow channel is built by analysis of forces acting on the bubble, and effects of bubble interface parameters such as the bubble inclination angle, upstream contact angle, downstream contact angle and bubble contact diameter on predicted bubble departure diameters in a narrow channel are analysed by comparing with the visual experimental data. Based on the above results, the bubble interface parameters as the input parameters used to obtain the bubble departure diameter in a narrow channel are assured, and the bubble departure diameters in a narrow channel are predicted by solving the force equation. The predicted bubble departure diameters are verified by the 58 bubble departure diameters obtained from the vertical and inclined visual experiment, and the predicted results agree with the experimental results. The different forces acting on the bubble are obtained and the effect of thermal parameters in this experiment on bubble departure diameters is analysed. (authors)

Convective mass transfer around a dissolving bubble

Science.gov (United States)

Duplat, Jerome; Grandemange, Mathieu; Poulain, Cedric

2017-11-01

Heat or mass transfer around an evaporating drop or condensing vapor bubble is a complex issue due to the interplay between the substrate properties, diffusion- and convection-driven mass transfer, and Marangoni effects, to mention but a few. In order to disentangle these mechanisms, we focus here mainly on the convective mass transfer contribution in an isothermal mass transfer problem. For this, we study the case of a millimetric carbon dioxide bubble which is suspended under a substrate and dissolved into pure liquid water. The high solubility of CO2 in water makes the liquid denser and promotes a buoyant-driven flow at a high (solutal) Rayleigh number (Ra˜104 ). The alteration of p H allows the concentration field in the liquid to be imaged by laser fluorescence enabling us to measure both the global mass flux (bubble volume, contact angle) and local mass flux around the bubble along time. After a short period of mass diffusion, where the boundary layer thickens like the square root of time, convection starts and the CO2 is carried by a plume falling at constant velocity. The boundary layer thickness then reaches a plateau which depends on the bubble cross section. Meanwhile the plume velocity scales like (dV /d t )1 /2 with V being the volume of the bubble. As for the rate of volume loss, we recover a constant mass flux in the diffusion-driven regime followed by a decrease in the volume V like V2 /3 after convection has started. We present a model which agrees well with the bubble dynamics and discuss our results in the context of droplet evaporation, as well as high Rayleigh convection.

FEASTING BLACK HOLE BLOWS BUBBLES

Science.gov (United States)

2002-01-01

A monstrous black hole's rude table manners include blowing huge bubbles of hot gas into space. At least, that's the gustatory practice followed by the supermassive black hole residing in the hub of the nearby galaxy NGC 4438. Known as a peculiar galaxy because of its unusual shape, NGC 4438 is in the Virgo Cluster, 50 million light-years from Earth. These NASA Hubble Space Telescope images of the galaxy's central region clearly show one of the bubbles rising from a dark band of dust. The other bubble, emanating from below the dust band, is barely visible, appearing as dim red blobs in the close-up picture of the galaxy's hub (the colorful picture at right). The background image represents a wider view of the galaxy, with the central region defined by the white box. These extremely hot bubbles are caused by the black hole's voracious eating habits. The eating machine is engorging itself with a banquet of material swirling around it in an accretion disk (the white region below the bright bubble). Some of this material is spewed from the disk in opposite directions. Acting like high-powered garden hoses, these twin jets of matter sweep out material in their paths. The jets eventually slam into a wall of dense, slow-moving gas, which is traveling at less than 223,000 mph (360,000 kph). The collision produces the glowing material. The bubbles will continue to expand and will eventually dissipate. Compared with the life of the galaxy, this bubble-blowing phase is a short-lived event. The bubble is much brighter on one side of the galaxy's center because the jet smashed into a denser amount of gas. The brighter bubble is 800 light-years tall and 800 light-years across. The observations are being presented June 5 at the American Astronomical Society meeting in Rochester, N.Y. Both pictures were taken March 24, 1999 with the Wide Field and Planetary Camera 2. False colors were used to enhance the details of the bubbles. The red regions in the picture denote the hot gas

LET dependence of bubbles evaporation pulses in superheated emulsion detectors

Energy Technology Data Exchange (ETDEWEB)

Di Fulvio, Angela; Huang, Jean; Staib, Lawrence [Yale University, Department of Diagnostic Radiology, TAC N140, New Haven, CT 06520-8043 (United States); D’Errico, Francesco [Yale University, Department of Diagnostic Radiology, TAC N140, New Haven, CT 06520-8043 (United States); Scuola di Ingegneria, Universitá di Pisa, Largo Lucio Lazzarino 1, Pisa (Italy)

2015-06-01

Superheated emulsion detectors are suspensions of metastable liquid droplets in a compliant inert medium. Upon interaction with ionizing radiation, the droplets evaporate, generating visible bubbles. Bubble expansion associated with the boiling of the droplets is accompanied by pressure pulses in both the sonic and ultrasonic frequency range. In this work, we analyzed the signal generated by bubble evaporation in the frequency and time domain. We used octafluoropropane (R-218) based emulsions, sensitive to both photons and neutrons. The frequency content of the detected pulses appears to extend well into the hundreds of kHz, beyond the range used in commercial devices to count bubbles as they are formed (typically 1–10 kHz). Kilohertz components characterize the early part of the waveforms, potentially containing information about the energetics of the explosive bubble initial growth phase. The power spectral density of the acoustic signal produced by neutron-induced evaporation shows a characteristic frequency pattern in the 200–400 kHz range, which is not observed when bubbles evaporate upon gamma ray-induced irradiation. For practical applications, detection of ultrasonic pulses associated with the boiling of the superheated drops can be exploited as a fast readout method, negligibly affected by mechanical ambient noise.

Gas transport into a cavitation bubble during the explosion

International Nuclear Information System (INIS)

Oldenziel, D.M.

1976-01-01

When considering cavitation bubbles exploding from small stream nuclei the surface tension plays an important role, and mostly negative pressures exist in the surroundings of such a bubble. During the short explosion time, the gas and vapor pressure in the bubble plays no important role in the dynamic process. The high radial velocity of the bubble wall introduces a steep gradient in the concentration of dissolved air near it, which results in some enforced gas transport into the bubble. During the bubble implosion it is necessary to take into account the amount of gas in the bubble, as it certainly plays an important role in exploring the cavitation erosion. In this survey the solution of a mathematical model for the gas diffusion process is compared with some experimental results

Bubble Collision in Curved Spacetime

International Nuclear Information System (INIS)

Hwang, Dong-il; Lee, Bum-Hoon; Lee, Wonwoo; Yeom, Dong-han

2014-01-01

We study vacuum bubble collisions in curved spacetime, in which vacuum bubbles were nucleated in the initial metastable vacuum state by quantum tunneling. The bubbles materialize randomly at different times and then start to grow. It is known that the percolation by true vacuum bubbles is not possible due to the exponential expansion of the space among the bubbles. In this paper, we consider two bubbles of the same size with a preferred axis and assume that two bubbles form very near each other to collide. The two bubbles have the same field value. When the bubbles collide, the collided region oscillates back-and-forth and then the collided region eventually decays and disappears. We discuss radiation and gravitational wave resulting from the collision of two bubbles

Interfacial Bubble Deformations

Science.gov (United States)

Seymour, Brian; Shabane, Parvis; Cypull, Olivia; Cheng, Shengfeng; Feitosa, Klebert

Soap bubbles floating at an air-water experience deformations as a result of surface tension and hydrostatic forces. In this experiment, we investigate the nature of such deformations by taking cross-sectional images of bubbles of different volumes. The results show that as their volume increases, bubbles transition from spherical to hemispherical shape. The deformation of the interface also changes with bubble volume with the capillary rise converging to the capillary length as volume increases. The profile of the top and bottom of the bubble and the capillary rise are completely determined by the volume and pressure differences. James Madison University Department of Physics and Astronomy, 4VA Consortium, Research Corporation for Advancement of Science.

Fama on bubbles

DEFF Research Database (Denmark)

Engsted, Tom

Eugene Fama has repeatedly expressed his discontent with the notion of an irrational bubble. However, he has never publicly expressed his opinion on rational bubbles. This is peculiar since such bubbles build naturally from the rational efficient markets paradigm that Fama strongly adheres to...

Numerical investigation of interaction between rising bubbles in a viscous liquid

Energy Technology Data Exchange (ETDEWEB)

Yoon, Ik Roh [Korea Institute of Marine Science and Technology Promotion, Seoul (Korea, Republic of); Shin Seung Won [Hongik University, Seoul (Korea, Republic of)

2016-07-15

The rising behavior of bubbles undergoing bubble-bubble interaction in a viscous liquid is studied using a two-dimensional direct numerical simulation. Level contour reconstruction method (LCRM), one of the connectivity-free front tracking methods, is applied to describe a moving interface accurately under highly deformable conditions. This work focuses on the effects of bubble size on the interaction of two bubbles rising side-by-side in a stagnant liquid. Several characteristics of bubble-bubble interaction are analyzed quantitatively as supported by energy analysis. The results showed clear differences between small and large bubbles with respect to their interaction behavior in terms of lateral movement, vortex intensity, suppression of surface deformation, and viscous dissipation rate. Distributions of vorticity and viscous dissipation rate near the bubble interfaces also differed depending on the size of the bubbles. Strong vortices from large bubbles triggered oscillation in bubble-bubble interaction and played a dominant role in the interaction process as the size of bubbles increases.

Prokaryotic Expression of Reindeer β-defensin-1 (reBD-1) Gene and Bioactivity Identification of the Recombinant Protein%驯鹿β-防御素-1(reBD-1)基因的原核表达及蛋白活性的鉴定

Institute of Scientific and Technical Information of China (English)

苏丽娜; 杨银凤; 景岚; 曹贵方

2011-01-01

The aim of this experiment was to construct prokaryotic expression vector of reindeer β-defensin-l(reBD-l), induce the expression of reBD-1 fusion protein in E. Coli, and evaluate the bioactivity of the expression products. The prepro-peptide of reBD-1 was amplified by RT-PCR. The mature peptide of encoding reBD-1 was amplified from recombinant cloning vector PMD19T/ reBD-1, and then cloned into pET-32a (+ ), in which reBD-1 fusion protein expression was induced by IPTG in E. Coli BL2KDE3). The expressed product was further cultured and purified for experiment of bacteriostasis in vitro. The results showed that the amplified products of prepro-peptide and mature peptide were 215 and 138 bp, respectively, and the homology of the sequences of the targeted gene and reBD-1 mRNA was up to 100%. The molecular weight of fusion proteins of prepro-peptide and mature peptide were 28 and 24 ku. The agar diffusion method has demonstrated that 0. 08 mg · mL-1 purified mature peptide protein has obvious antimicrobial activity against S. Aureus and E. Coli. From the results we can conclude that the prepro-peptide and mature peptides have high expression level in E. Coli, and the mature peptide has resistance to both Gram negative and Gram positive bacteria.%旨在构建驯鹿β防御素-1(Reindeerβ-defensin-1,reBD-1)基因的原核表达载体pET-32a(+ )/reBD-1,诱导reBD-1融合蛋白在大肠杆菌中表达,并对其表达产物的生物学活性进行评价.利用RT-PCR技术扩增reBD-1前原肽.从重组克隆载体PMD19T/reBD-1中扩增reBD-1成熟肽编码基因,并克隆入pET-32a(+)中,在大肠杆菌BL21 (DE3)中用IPTG诱导表达reBD-1融合蛋白.表达的融合蛋白扩大培养,进一步纯化后进行体外抑菌试验.结果表明,reBD-1前原肽和成熟肽扩增产物大小分别为215和138 bp,目的基因的序列与驯鹿防御素-1 mRNA序列同源性为100％.前原肽和成熟肽融合蛋白分子量分别为28和24 ku.利用琼脂糖扩散法表明,0

An experimental study on bubble behavior in a vertical round tube

International Nuclear Information System (INIS)

Nishiura, Masanori; Torimoto, Kazuhiro; Okawa, Tomio; Kataoka, Isao

2002-01-01

Using filtrated and deionized tap water as a liquid phase, isolated gas bubbles rising in turbulent upflow in a vertical round tube were videotaped by two high-speed video cameras to measure their equilibrium positions in the radial direction. The measurements were conducted in normal and high temperatures and the flowrate of liquid phase was parametrically changed; the range of measured bubble sizes was 0.35-3.8 mm. The video data revealed that the bubble whose sphere-equivalent diameter is approximately smaller than 1 mm is more probably located in the center part in the tube, while the bubble approximately larger than 1.5 mm is more probably located near the wall; we call these bubbles coring and sliding bubbles, respectively. The critical bubble size for the transition from coring to sliding bubbles increased with the increase of liquid flowrate but it was not significantly affected by the water temperature. The present experimental data of the equilibrium radial bubble position in turbulent upflow would be important information to consider the local void fraction near the heated wall in flow boiling. (author)

ON THE ANALYSIS OF BUBBLE CHAMBER TRACKS

International Nuclear Information System (INIS)

Bradner, H.; Solmitz, F.

1958-01-01

Since its invention by Glaser in 1953, the bubble chamber has become a most valuable tool in high-energy physics. It combines a number of advantages of various older methods of particle detection: it offers high spatial resolution, rapid accumulation of data, some time resolution, and some choice of the nucleus whose interaction one wants to study (bubble chambers have been made to operate with a large number of different liquids, including H 2 , D 2 , He, Xe, and several hydrocarbons). In order to exploit the advantages of spatial resolution and rapid data accumulation, high-speed high-precision analysis procedures must be developed. In this article they discuss some of the problems posed by such analysis. The discussion is based largely on experience gained in performing hydrogen bubble chamber experiments with the University of California's Bevatron (6-Bev proton synchrotron)

An experimental study of particle-bubble interaction and attachment in flotation

KAUST Repository

Sanchez Yanez, Aaron

2017-01-01

bubbles were observed using two high speed cameras. The cameras were placed perpendicular to each other allowing to reconstruct the three-dimensional position of the particle, the bubble and the particle-bubble aggregate. A single size of particle was used varying the size for the bubbles. It was found that the attachment of a particle to a bubble depends on its degree of hydrophobicity and on the relative position of the particle and the bubble before they encounter.

Two-dimensional direct numerical simulation of bubble cloud cavitation by front-tracking method

International Nuclear Information System (INIS)

Peng, G; Shimizu, S; Tryggvason, G

2015-01-01

Unsteady bubble cloud cavitation phenomenon caused by negative pressure pulse has been treated numerically by applying a front tracking method. The behaviour of bubble cloud expanding and contracting is evaluated by tracking the motion of all bubble interfaces. Numerical investigation demonstrates that: (1) In the collapsing of bubble cloud micro liquid jets toward the inner bubbles are formed while the outer layer bubbles contract extremely, and then a high impact pressure is released when the inner central bubble contacts to its minimum. (2) The oscillation of bubble cloud depends upon the void fraction greatly. In the case of high void fraction, the frequency of cloud oscillation is lower than that of individual bubble and the decay of the oscillation becomes much slowly also

Investigation of the reaction {sup 4}He(γ, pn)d at energies below the meson-production threshold

Energy Technology Data Exchange (ETDEWEB)

Khodyachikh, A. F.; Gorbenko, E. S.; Murtazin, R. T., E-mail: rumurtazin@gmail.com [Kharkiv Institute of Physics and Technology: National Science Center (Ukraine)

2017-01-15

The momentum distributions of deuterons and nucleons from the reaction {sup 4}He(γ, pn)d induced by bremsstrahlung photons whose spectrum extends up to the endpoint energy of 150 MeV were measured by means of a diffusion chamber placed in a magnetic field. These measurements were performed in four photon-energy intervals for deuterons and in the energy range between 100 and 150 MeV for nucleons. Angular and energy correlations of nucleons were measured at photon energies in the interval between 50 and 70 MeV. The results obtained in this way were analyzed on the basis of the quasideuteron model. The probability for final-state nucleon–deuteron interaction was estimated.

Drop impact entrapment of bubble rings

KAUST Repository

Thoraval, M.-J.

2013-04-29

We use ultra-high-speed video imaging to look at the initial contact of a drop impacting on a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et al. (Phys. Rev. Lett., vol. 108, 2012, article 264506). These dynamics mainly occur within 50 -s after the first contact, requiring imaging at 1 million f.p.s. For a water drop impacting on a thin layer of water, the entrapment of isolated bubbles starts through azimuthal instability, which forms at low impact velocities, in the neck connecting the drop and pool. For Reynolds number Re above -12 000, up to 10 partial bubble rings have been observed at the base of the ejecta, starting when the contact is -20% of the drop size. More regular bubble rings are observed for a pool of ethanol or methanol. The video imaging shows rotation around some of these air cylinders, which can temporarily delay their breakup into micro-bubbles. The different refractive index in the pool liquid reveals the destabilization of the vortices and the formation of streamwise vortices and intricate vortex tangles. Fine-scale axisymmetry is thereby destroyed. We show also that the shape of the drop has a strong influence on these dynamics. 2013 Cambridge University Press.

Bubbling away

International Nuclear Information System (INIS)

Anon.

1993-01-01

Bubble chambers may have almost vanished from the front line of physics research, but the vivid memory of their intricate and sometimes beautiful patterns of particle tracks lives on, and has greatly influenced the computer graphics of track reconstruction in today's big experiments. 'Seeing' an interaction makes it more understandable. Bubble chambers, with their big collaborations of physicists from many widely scattered research institutes, started another ball rolling. The groups formed are even now only surpassed in size by the big collaborations working on today's major detectors at colliding beam machines. From 14-16 July, about 130 physicists gathered at CERN to commemorate the 40th anniversary of the invention of the bubble chamber by Donald Glaser. The meeting, organized by Derek C. Colley from Birmingham, gave a comprehensive overview of bubble chamber contributions to physics, their challenging technology, and the usefulness of bubble chamber photographs in education, both for physics and the public at large. After opening remarks by CERN Director Carlo Rubbia, Donald Glaser began with a brief review of the work which led to his invention - there was much more to it than idly watching beer bubbles rise up the wall of the glass - before turning to his present line of research, biophysics, also very visually oriented

Establishment of Measurement Techniques for Sliding Bubble on a Horizontal Tube

International Nuclear Information System (INIS)

Kim, Yu-Na Kim; Park, Goon-Cherl; Cho, Hyoung-Kyu

2015-01-01

The mechanistic wall boiling model includes many parameters relevant with bubble behaviors, such as the bubble departure diameter, bubble lift-off diameter, bubble waiting time, etc. Although there have been a large number of studies investigating bubble behavior, the subjects of observation are almost bubbles on a plane or vertical tube. Since the bubble motion is highly influenced by the directions of gravitational force and the heating surfaces, it is expected that the bubble behavior on a horizontal tube is largely different from those on the other geometry. The heat exchanger of APR+ has horizontal U-tube configuration installed in a water pool, of which diameter is 50mm. The study aims to establish measurement techniques for sliding bubbles on a horizontal tube. The measurement parameters include the diameter, interface area, volume, and velocity of the bubble. Additionally, in order to analyze the force acting on the bubble, liquid velocity measurement method was proposed. This paper presents the procedure of the measurement; the phase separation technique, 3-D reconstruction technique, and velocity measurement techniques. For visualization of the sliding bubble behavior, bubble and liquid velocity measurement methods were established which use two high speed cameras and a continuous LASER for the PTV and PIV. Three steps for the bubble shape and velocity measurement (the phase separation, 3-D reconstruction, and velocity calculation), were successfully set up and verified. A PIV technique which uses two different time duration for two regions where the velocity difference is huge was proposed and tested. Using these methods, various information regarding a sliding bubble can be obtained such as bubble and liquid velocities, shape, volume, surface area etc

Bubble masks for time-encoded imaging of fast neutrons.

Energy Technology Data Exchange (ETDEWEB)

Brubaker, Erik; Brennan, James S.; Marleau, Peter; Nowack, Aaron B.; Steele, John T.; Sweany, Melinda; Throckmorton, Daniel J.

2013-09-01

Time-encoded imaging is an approach to directional radiation detection that is being developed at SNL with a focus on fast neutron directional detection. In this technique, a time modulation of a detected neutron signal is inducedtypically, a moving mask that attenuates neutrons with a time structure that depends on the source position. An important challenge in time-encoded imaging is to develop high-resolution two-dimensional imaging capabilities; building a mechanically moving high-resolution mask presents challenges both theoretical and technical. We have investigated an alternative to mechanical masks that replaces the solid mask with a liquid such as mineral oil. Instead of fixed blocks of solid material that move in pre-defined patterns, the oil is contained in tubing structures, and carefully introduced air gapsbubblespropagate through the tubing, generating moving patterns of oil mask elements and air apertures. Compared to current moving-mask techniques, the bubble mask is simple, since mechanical motion is replaced by gravity-driven bubble propagation; it is flexible, since arbitrary bubble patterns can be generated by a software-controlled valve actuator; and it is potentially high performance, since the tubing and bubble size can be tuned for high-resolution imaging requirements. We have built and tested various single-tube mask elements, and will present results on bubble introduction and propagation as a function of tubing size and cross-sectional shape; real-time bubble position tracking; neutron source imaging tests; and reconstruction techniques demonstrated on simple test data as well as a simulated full detector system.

Bubble coalescence in a Newtonian fluid

Science.gov (United States)

Garg, Vishrut; Basaran, Osman

2017-11-01

Bubble coalescence plays a central role in the hydrodynamics of gas-liquid systems such as bubble column reactors, spargers, and foams. Two bubbles approaching each other at velocity V coalesce when the thin film between them ruptures, which is often the rate-limiting step. Experimental studies of this system are difficult, and recent works provide conflicting results on the effect of V on coalescence times. We simulate the head-on approach of two bubbles of equal radii R in an incompressible Newtonian fluid (density ρ, viscosity μ, and surface tension σ) by solving numerically the free boundary problem comprised of the Navier Stokes and continuity equations. Simulations are made challenging by the existence of highly disparate lengthscales, i.e. film thickness and drop radii, which are resolved by using the method of elliptic mesh generation. For a given liquid, the bubbles are shown to coalesce for all velocities below a critical value. The effects of Ohnesorge number Oh = μ /√{ ρσR } on coalescence time and critical velocity are also investigated.

Sensitivity analysis of bubble size and probe geometry on the measurements of interfacial area concentration in gas-liquid two-phase flow

International Nuclear Information System (INIS)

Kataoka, Isao; Ishii, Mamoru; Serizawa, Akimi

1994-01-01

Interfacial area concentration measurement is quite important in gas-liquid two-phase flow. To determine the accuracy of measurement of the interfacial area using electrical resistivity probes, numerical simulations of a passing bubble through sensors are carried out. The two-sensors method, the four-sensors method and the correlative method are tested and the effects of sensor spacing, bubble diameter and hitting angle of the bubbles on the accuracy of each measurement method are investigated. The results indicated that the two-sensors method is insensitive to the ratio between sensor spacing and bubble diameter, and hitting angle. It overestimates the interfacial area for small hitting angles while it gives a reasonable accuracy for smaller bubbles and large hitting angles. The four-sensors method gives accurate interfacial area measurements particularly for the larger bubble diameters and smaller hitting angles, while for smaller bubbles and larger hitting angles, the escape probability of bubbles through the sensors becomes large and the accuracy becomes worse. The correlative method gives an overall accuracy for interfacial area measurement. Particularly, it gives accurate measurements for large bubbles and larger hitting angles while for smaller hitting angles, the spatial dependence of the correlation functions affects the accuracy. (orig.)

Approaching behavior of a pair of spherical bubbles in quiescent liquids

Science.gov (United States)

Sanada, Toshiyuki; Kusuno, Hiroaki

2015-11-01

Some unique motions related bubble-bubble interaction, such as equilibrium distance, wake induced lift force, have been proposed by theoretical analysis or numerical simulations. These motions are different from the solid spheres like DKT model (Drafting, Kissing and Tumbling). However, there is a lack of the experimental verification. In this study, we experimentally investigated the motion of a pair of bubbles initially positioned in-line configuration in ultrapure water or an aqueous surfactant solution. The bubble motion were observed by two high speed video cameras. The bubbles Reynolds number was ranged from 50 to 300 and bubbles hold the spherical shape in this range. In ultrapure water, initially the trailing bubble deviated from the vertical line on the leading bubble owing to the wake of the leading bubble. And then, the slight difference of the bubble radius changed the relative motion. When the trailing bubble slightly larger than the leading bubble, the trailing bubble approached to the leading bubble due to it's buoyancy difference. The bubbles attracted and collided only when the bubbles rising approximately side by side configuration. In addition, we will also discuss the motion of bubbles rising in an aqueous surfactant solution.

Cap Bubble Drift Velocity in a Confined Test Section

International Nuclear Information System (INIS)

Xiaodong Sun; Seungjin Kim; Mamoru Ishii; Lincoln, Frank W.; Beus, Stephen G.

2002-01-01

In the two-group interfacial area transport equation, bubbles are categorized into two groups, i.e., spherical/distorted bubbles as group 1 and cap/slug/churn-turbulent bubbles as group 2. The bubble rise velocities for both groups of bubbles may be estimated by the drift flux model by applying different distribution parameters and drift velocities for both groups. However, the drift velocity for group 2 bubbles is not always applicable (when the wall effect becomes important) as in the current test loop of interest where the flow channel is confined by two parallel flat walls, with a dimension of 200-mm in width and 10-mm in gap. The previous experiments indicated that no stable slug flow existed in this test section, which was designed to permit visualization of the flow patterns and bubble characteristics without the distortion associated with curved surfaces. In fact, distorted cap bubbly and churn-turbulent flow was observed. Therefore, it is essential to developed a correlation for cap bubble drift velocity in this confined flow channel. Since the rise velocity of a cap bubble depends on its size, a high-speed movie camera is used to capture images of cap bubbles to obtain the bubble size information. Meanwhile, the rise velocity of cap and elongated bubbles (called cap bubbles hereafter) is investigated by examining the captured images frame by frame. As a result, the conventional correlation of drift velocity for slug bubbles is modified and acceptable agreements between the measurements and correlation estimation are achieved

Bubbly flows around a two-dimensional circular cylinder

Science.gov (United States)

Lee, Jubeom; Park, Hyungmin

2016-11-01

Two-phase cross flows around a bluff body occur in many thermal-fluid systems like steam generators, heat exchangers and nuclear reactors. However, our current knowledge on the interactions among bubbles, bubble-induced flows and the bluff body are limited. In the present study, the gas-liquid bubbly flows around a solid circular cylinder are experimentally investigated while varying the mean void fraction from 5 to 27%. The surrounding liquid (water) is initially static and the liquid flow is only induced by the air bubbles. For the measurements, we use the high-speed two-phase particle image velocimetry techniques. First, depending on the mean void fraction, two regimes are classified with different preferential concentration of bubbles in the cylinder wake, which are explained in terms of hydrodynamic force balances acting on rising bubbles. Second, the differences between the two-phase and single-phase flows (while matching their Reynolds numbers) around a circular cylinder will be discussed in relation to effects of bubble dynamics and the bubble-induced turbulence on the cylinder wake. Supported by a Grant (MPSS-CG-2016-02) through the Disaster and Safety Management Institute funded by Ministry of Public Safety and Security of Korean government.

Inertial collapse of bubble pairs near a solid surface

Science.gov (United States)

Alahyari Beig, Shahaboddin; Johnsen, Eric

2017-11-01

Cavitation occurs in a variety of applications ranging from naval structures to biomedical ultrasound. One important consequence is structural damage to neighboring surfaces following repeated inertial collapse of vapor bubbles. Although the mechanical loading produced by the collapse of a single bubble has been widely investigated, less is known about the detailed dynamics of the collapse of multiple bubbles. In such a problem, the bubble-bubble interactions typically affect the dynamics, e.g., by increasing the non-sphericity of the bubbles and amplifying/hindering the collapse intensity depending on the flow parameters. Here, we quantify the effects of bubble-bubble interactions on the bubble dynamics, as well as the pressures/temperatures produced by the collapse of a pair of gas bubbles near a rigid surface. We perform high-resolution simulations of this problem by solving the three-dimensional compressible Navier-Stokes equations for gas/liquid flows. The results are used to investigate the non-spherical bubble dynamics and characterize the pressure and temperature fields based on the relevant parameters entering the problem: stand-off distance, geometrical configuration (angle, relative size, distance), collapse strength. This research was supported in part by ONR Grant N00014-12-1-0751 and NSF Grant CBET 1253157.

Sensitivity and specificity of the mood disorder questionnaire and the bipolar spectrum diagnostic scale in Argentinean patients with mood disorders.

Science.gov (United States)

Zaratiegui, Rodolfo M; Vázquez, Gustavo H; Lorenzo, Laura S; Marinelli, Marcia; Aguayo, Silvia; Strejilevich, Sergio A; Padilla, Eduardo; Goldchluk, Aníbal; Herbst, Luis; Vilapriño, Juan J; Bonetto, Gerardo García; Cetkovich-Bakmas, Marcelo G; Abraham, Estela; Kahn, Clara; Whitham, Elizabeth A; Holtzman, Niki S; Ghaemi, Nassir

2011-08-01

To assess the sensitivity and specificity of two self-report instruments for detection of bipolarity in a sample of Argentinean patients. Spanish versions of the MDQ and the BSDS were administered over four months at 11 sites in Argentina. Diagnoses were made using DSM-IV criteria and the MINI. The study sample consisted of patients diagnosed with Bipolar Disorder (BD) Types I, II, or NOS. BDNOS diagnoses were made using extended guidelines for bipolar spectrum symptoms. Unipolar patients were used as a control group. Of 493 patients screened, 354 completed evaluation by MDQ and MINI, and 363 by BSDS and MINI. Specificity of MDQ was 0.97 and BSDS was 0.81. MDQ sensitivity was 0.70 for bipolar type I (BD-I), 0.52 for bipolar II (BD-II) and 0.31 for bipolar not otherwise specified (BDNOS). BSDS sensitivities were 0.75, 0.70 and 0.51 respectively. This study was performed in specialized outpatient settings and thus its results are not necessarily representative for other clinical settings. There was not a systematic evaluation of comorbid psychiatric disease or test-retest reliability. The local versions of the MDQ and the BSDS showed a sensitivity and specificity comparable to previous research. Our results indicate that in this sample, MDQ was more specific for BD and BSDS was more sensitive to detect BD-II and NOS. Since BD-I is more readily recognized than bipolar spectrum disorders, enhanced sensitivity of BSDS for soft bipolarity may be an advantage. Copyright © 2011 Elsevier B.V. All rights reserved.

One-dimensional nodal neutronics routines for the TRAC-BD1 thermal-hydraulics program

International Nuclear Information System (INIS)

Nigg, D.W.

1983-09-01

Nuclear reactor core transient neutronic behavior is currently modeled in the TRAC-BD1 code using a point-reactor kinetics formulation. This report describes a set of subroutines based on the Analytic Nodal Method that were written to provide TRAC-BD1 with a one-dimensional space-dependent neutronics capability. Use of the routines is illustrated with several test problems. The results of these problems show that the Analytic Nodal neutronics routines have desirable accuracy and computing time characteristics and should be a useful addition to TRAC-BD1

Bubble detector measurements of a mixed radiation field from antiproton annihilation

International Nuclear Information System (INIS)

Bassler, Niels; Knudsen, Helge; Moller, Soren Pape; Petersen, Jorgen B.; Rahbek, Dennis; Uggerhoj, Ulrik I.

2006-01-01

In the light of recent progress in the study of the biological potential of antiproton tumour treatment it is important to be able to characterize the neutron intensity arising from antiproton annihilation using simple, compact and reliable detectors. The intensity of fast neutrons from antiproton annihilation on polystyrene has been measured with bubble detectors and a multiplicity has been derived as well as an estimated neutron equivalent dose. Additionally the sensitivity of bubble detectors towards protons was measured

Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations

Science.gov (United States)

Paul W. Bradley; Stephanie S. Gervasi; Jessica Hua; Rickey D. Cothran; Rick A. Relyea; Deanna H. Olson; Andrew R. Blaustein

2015-01-01

Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However,...

Bubble and boundary layer behaviour in subcooled flow boiling

Energy Technology Data Exchange (ETDEWEB)

Maurus, Reinhold; Sattelmayer, Thomas [Lehrstuhl fuer Thermodynamik, Technische Universitaet Muenchen, 85747 Garching (Germany)

2006-03-15

Subcooled flow boiling is a commonly applied technique for achieving efficient heat transfer. In the study, an experimental investigation in the nucleate boiling regime was performed for water circulating in a closed loop at atmospheric pressure. The horizontal orientated test-section consists of a rectangular channel with a one side heated copper strip and good optical access. Various optical observation techniques were applied to study the bubble behaviour and the characteristics of the fluid phase. The bubble behaviour was recorded by the high-speed cinematography and by a digital high resolution camera. Automated image processing and analysis algorithms developed by the authors were applied for a wide range of mass flow rates and heat fluxes in order to extract characteristic length and time scales of the bubbly layer during the boiling process. Using this methodology, the bubbles were automatically analysed and the bubble size, bubble lifetime, waiting time between two cycles were evaluated. Due to the huge number of observed bubbles a statistical analysis was performed and distribution functions were derived. Using a two-dimensional cross-correlation algorithm, the averaged axial phase boundary velocity profile could be extracted. In addition, the fluid phase velocity profile was characterised by means of the particle image velocimetry (PIV) for the single phase flow as well as under subcooled flow boiling conditions. The results indicate that the bubbles increase the flow resistance. The impact on the flow exceeds by far the bubbly region and it depends on the magnitude of the boiling activity. Finally, the ratio of the averaged phase boundary velocity and of the averaged fluid velocity was evaluated for the bubbly region. (authors)

Two types of nonlinear wave equations for diffractive beams in bubbly liquids with nonuniform bubble number density.

Science.gov (United States)

Kanagawa, Tetsuya

2015-05-01

This paper theoretically treats the weakly nonlinear propagation of diffracted sound beams in nonuniform bubbly liquids. The spatial distribution of the number density of the bubbles, initially in a quiescent state, is assumed to be a slowly varying function of the spatial coordinates; the amplitude of variation is assumed to be small compared to the mean number density. A previous derivation method of nonlinear wave equations for plane progressive waves in uniform bubbly liquids [Kanagawa, Yano, Watanabe, and Fujikawa (2010). J. Fluid Sci. Technol. 5(3), 351-369] is extended to handle quasi-plane beams in weakly nonuniform bubbly liquids. The diffraction effect is incorporated by adding a relation that scales the circular sound source diameter to the wavelength into the original set of scaling relations composed of nondimensional physical parameters. A set of basic equations for bubbly flows is composed of the averaged equations of mass and momentum, the Keller equation for bubble wall, and supplementary equations. As a result, two types of evolution equations, a nonlinear Schrödinger equation including dissipation, diffraction, and nonuniform effects for high-frequency short-wavelength case, and a Khokhlov-Zabolotskaya-Kuznetsov equation including dispersion and nonuniform effects for low-frequency long-wavelength case, are derived from the basic set.

Pseudopotential multi-relaxation-time lattice Boltzmann model for cavitation bubble collapse with high density ratio

International Nuclear Information System (INIS)

Shan Ming-Lei; Zhu Chang-Ping; Yao Cheng; Yin Cheng; Jiang Xiao-Yan

2016-01-01

The dynamics of the cavitation bubble collapse is a fundamental issue for the bubble collapse application and prevention. In the present work, the modified forcing scheme for the pseudopotential multi-relaxation-time lattice Boltzmann model developed by Li Q et al. [Li Q, Luo K H and Li X J 2013 Phys. Rev. E 87 053301] is adopted to develop a cavitation bubble collapse model. In the respects of coexistence curves and Laplace law verification, the improved pseudopotential multi-relaxation-time lattice Boltzmann model is investigated. It is found that the thermodynamic consistency and surface tension are independent of kinematic viscosity. By homogeneous and heterogeneous cavitation simulation, the ability of the present model to describe the cavitation bubble development as well as the cavitation inception is verified. The bubble collapse between two parallel walls is simulated. The dynamic process of a collapsing bubble is consistent with the results from experiments and simulations by other numerical methods. It is demonstrated that the present pseudopotential multi-relaxation-time lattice Boltzmann model is applicable and efficient, and the lattice Boltzmann method is an alternative tool for collapsing bubble modeling. (paper)

Electron acceleration in the bubble regime

Energy Technology Data Exchange (ETDEWEB)

Jansen, Oliver

2014-02-03

The bubble regime of laser-wakefield acceleration has been studied over the recent years as an important alternative to classical accelerators. Several models and theories have been published, in particular a theory which provides scaling laws for acceleration parameters such as energy gain and acceleration length. This thesis deals with numerical simulations within the bubble regime, their comparison to these scaling laws and data obtained from experiments, as well as some specific phenomenona. With a comparison of the scaling laws with numerical results a parameter scan was able to show a large parameter space in which simulation and theory agree. An investigation of the limits of this parameter space revealed boundaries to other regimes, especially at very high (a{sub 0} > 100) and very low laser amplitudes (a{sub 0} < 4). Comparing simulation data with data from experiments concerning laser pulse development and electron energies, it was found that experimental results can be adequately reproduced using the Virtual-Laser-Plasma-Laboratory code. In collaboration with the Institut fuer Optik und Quantenelektronik at the Friedrich-Schiller University Jena synchrotron radiation emitted from the inside of the bubble was investigated. A simulation of the movement of the electrons inside the bubble together with time dependent histograms of the emitted radiation helped to prove that the majority of radiation created during a bubble acceleration originates from the inside of the bubble. This radiation can be used to diagnose the amplitude of oscillation of the trapped electrons. During a further study it was proven that the polarisation of synchrotron radiation from a bubble contains information about the exact oscillation direction. This oscillation was successfully controlled by using either a laser pulse with a tilted pulse front or an asymmetric laser pulse. First results of ongoing studies concerning injecting electrons into an existing bubble and a scheme called

Magnetic-bubble devices

International Nuclear Information System (INIS)

Fairholme, R.J.

1978-01-01

Magnetic bubbles were first described only ten years ago when research workers were discussing orthoferrites containing μm diameter bubbles. However, problems of material fabrication limit crystals to a few mm across which severely curtailed device development. Since then materials have changed and rare-earth-iron garnet films can be grown up 3 inches in diameter with bubble diameters down to sizes below 1 μm. The first commercial products have device capacities in the range 64 000 to 100 000 bits with bubble diameters between 4 and 6 μm. Chip capacities of 1 Mbit are presently under development in the laboratory, as are new techniques to use submicrometre bubbles. The operation and fabrication of a bubble device is described using the serial loop devices currently being manufactured at Plessey as models. Chip organization is one important variable which directly affects the access time. A range of access times and capacities is available which offers a wide range of market opportunities, ranging from consumer products to fixed head disc replacements. some of the application areas are described. (author)

AutoBD: Automated Bi-Level Description for Scalable Fine-Grained Visual Categorization.

Science.gov (United States)

Yao, Hantao; Zhang, Shiliang; Yan, Chenggang; Zhang, Yongdong; Li, Jintao; Tian, Qi

Compared with traditional image classification, fine-grained visual categorization is a more challenging task, because it targets to classify objects belonging to the same species, e.g. , classify hundreds of birds or cars. In the past several years, researchers have made many achievements on this topic. However, most of them are heavily dependent on the artificial annotations, e.g., bounding boxes, part annotations, and so on . The requirement of artificial annotations largely hinders the scalability and application. Motivated to release such dependence, this paper proposes a robust and discriminative visual description named Automated Bi-level Description (AutoBD). "Bi-level" denotes two complementary part-level and object-level visual descriptions, respectively. AutoBD is "automated," because it only requires the image-level labels of training images and does not need any annotations for testing images. Compared with the part annotations labeled by the human, the image-level labels can be easily acquired, which thus makes AutoBD suitable for large-scale visual categorization. Specifically, the part-level description is extracted by identifying the local region saliently representing the visual distinctiveness. The object-level description is extracted from object bounding boxes generated with a co-localization algorithm. Although only using the image-level labels, AutoBD outperforms the recent studies on two public benchmark, i.e. , classification accuracy achieves 81.6% on CUB-200-2011 and 88.9% on Car-196, respectively. On the large-scale Birdsnap data set, AutoBD achieves the accuracy of 68%, which is currently the best performance to the best of our knowledge.Compared with traditional image classification, fine-grained visual categorization is a more challenging task, because it targets to classify objects belonging to the same species, e.g. , classify hundreds of birds or cars. In the past several years, researchers have made many achievements on this topic

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study

Directory of Open Access Journals (Sweden)

Moreno-Manzanaro Miriam

2011-04-01

Full Text Available Abstract Background Studies in bipolar disorder (BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd (NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales, adherence to treatment (DAI-10 scale and Medication Possession Ratio, quality of life (EQ-5D scale, healthcare resources, and caregiver burden (BAS scale

Electron self-injection and trapping into an evolving plasma bubble.

Science.gov (United States)

Kalmykov, S; Yi, S A; Khudik, V; Shvets, G

2009-09-25

The blowout (or bubble) regime of laser wakefield acceleration is promising for generating monochromatic high-energy electron beams out of low-density plasmas. It is shown analytically and by particle-in-cell simulations that self-injection of the background plasma electrons into the quasistatic plasma bubble can be caused by slow temporal expansion of the bubble. Sufficient criteria for the electron trapping and bubble's expansion rate are derived using a semianalytic nonstationary Hamiltonian theory. It is further shown that the combination of bubble's expansion and contraction results in monoenergetic electron beams.

High-speed microjet generation using laser-induced vapor bubbles

Science.gov (United States)

Oudalov, Nikolai; Tagawa, Yoshiyuki; Peters, Ivo; Visser, Claas-Willem; van der Meer, Devaraj; Prosperetti, Andrea; Sun, Chao; Lohse, Detlef

2011-11-01

The generation and evolution of microjets are studied both experimentally and numerically. The jets are generated by focusing a laser pulse into a microscopic capillary tube (~50 μm) filled with water-based red dye. A vapor bubble is created instantly after shooting the laser (<1 μs), sending out a shockwave towards the curved free surface at which the high-speed microjet forms. The process of jet formation is captured using high-speed recordings at 1.0 × 106 fps. The velocity of the microjets can reach speeds of ~850 m/s while maintaining a very sharp geometry. The high-speed recordings enable us to study the effect of several parameters on the jet velocity, e.g. the absorbed energy and the distance between the laser spot and the free surface.The results show a clear dependence on these variables, even for supersonic speeds. Comparisons with numerical simulations confirm the nature of these dependencies.

Methamphetamine treatment during development attenuates the dopaminergic deficits caused by subsequent high-dose methamphetamine administration

OpenAIRE

McFadden, Lisa M; Hoonakker, Amanda J; Vieira-Brock, Paula L; Stout, Kristen A; Sawada, Nicole M; Ellis, Jonathan D; Allen, Scott C; Walters, Elliot T; Nielsen, Shannon M; Gibb, James W; Alburges, Mario E; Wilkins, Diana G; Hanson, Glen R; Fleckenstein, Annette E

2011-01-01

Administration of high doses of methamphetamine (METH) causes persistent dopaminergic deficits in both nonhuman preclinical models and METH-dependent persons. Noteworthy, adolescent (i.e., postnatal day (PND) 40) rats are less susceptible to this damage than young adult (PND90) rats. In addition, biweekly treatment with METH, beginning at PND40 and continuing throughout development, prevents the persistent dopaminergic deficits caused by a “challenge” high-dose METH regimen when administered ...

Differential Effects of Intermittent versus Continuous Haloperidol Treatment throughout Adolescence on Haloperidol Sensitization and Social Behavior in Adulthood

Science.gov (United States)

Gao, Jun; Li, Ming

2014-01-01

Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test. We also examined how these two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump (HAL-0.25 CONT; 0.25 mg/kg/day, n = 14) or daily injection (HAL-0.05 INT; 0.05 mg/kg/injection/day, sc, n = 14), or sterile water (n = 14) from postnatal days (PND) 44 to 71. HAL sensitization was assessed in a challenge test in which all rats were injected with HAL (0.025 and 0.05 mg/kg, sc) on PND 80 and PND 82. Two days later, half of the rats from each group (n = 7/group) were assayed in two 4-trial social interaction tests in which a subject rat was given four 5-min social encounters with a familiar or novel juvenile rat (PND 35–40) at 10 min intervals. Another half were tested in a quinpirole-induced hyperlocomotion assay to assess the potential HAL-induced change in D2-mediated function. Results show that only the intermittent dosing group under the HAL 0.05 mg/kg challenge showed a robust sensitization effect as rats in this group made significantly fewer avoidance responses than those in the vehicle and HAL-0.25 CONT groups. Adolescent HAL treatment did not affect social behavior and social memory, as rats from all 3 groups exhibited a similar level of social interaction and showed a similar level of sensitivity to the change of social stimuli. Similarly, adolescent HAL treatment also did not produce a long-lasting change in D2 function, as all 3 groups exhibited a

Towards classification of the bifurcation structure of a spherical cavitation bubble.

Science.gov (United States)

Behnia, Sohrab; Sojahrood, Amin Jafari; Soltanpoor, Wiria; Sarkhosh, Leila

2009-12-01

We focus on a single cavitation bubble driven by ultrasound, a system which is a specimen of forced nonlinear oscillators and is characterized by its extreme sensitivity to the initial conditions. The driven radial oscillations of the bubble are considered to be implicated by the principles of chaos physics and owing to specific ranges of control parameters, can be periodic or chaotic. Despite the growing number of investigations on its dynamics, there is not yet an inclusive yardstick to sort the dynamical behavior of the bubble into classes; also, the response oscillations are so complex that long term prediction on the behavior becomes difficult to accomplish. In this study, the nonlinear dynamics of a bubble oscillator was treated numerically and the simulations were proceeded with bifurcation diagrams. The calculated bifurcation diagrams were compared in an attempt to classify the bubble dynamic characteristics when varying the control parameters. The comparison reveals distinctive bifurcation patterns as a consequence of driving the systems with unequal ratios of R(0)lambda (where R(0) is the bubble initial radius and lambda is the wavelength of the driving ultrasonic wave). Results indicated that systems having the equal ratio of R(0)lambda, share remarkable similarities in their bifurcating behavior and can be classified under a unit category.

Impact of bubble wakes on a developing bubble flow in a vertical pipe

International Nuclear Information System (INIS)

Tomiyama, A.; Makino, Y.; Miyoshi, K.; Tamai, H.; Serizawa, A.; Zun, I.

1998-01-01

Three-dimensional two-way bubble tracking simulation of single large air bubbles rising through a stagnant water filled in a vertical pipe was conducted to investigate the structures of bubble wakes. Spatial distributions of time-averaged liquid velocity field, turbulent intensity and Reynolds stress caused by bubble wakes were deduced from the calculated local instantaneous liquid velocities. It was confirmed that wake structures are completely different from the ones estimated by a conventional wake model. Then, we developed a simple wake model based on the predicted time-averaged wake velocity fields, and implemented it into a 3D one-way bubble tracking method to examine the impact of bubble wake structures on time-spatial evolution of a developing air-water bubble flow in a vertical pipe. As a results, we confirmed that the developed wake model can give better prediction for flow pattern evolution than a conventional wake model

Experimental Analysis of a Bubble Wake Influenced by a Vortex Street

Directory of Open Access Journals (Sweden)

Sophie Rüttinger

2018-01-01

Full Text Available Bubble column reactors are ubiquitous in engineering processes. They are used in waste water treatment, as well as in the chemical, pharmaceutical, biological and food industry. Mass transfer and mixing, as well as biochemical or chemical reactions in such reactors are determined by the hydrodynamics of the bubbly flow. The hydrodynamics of bubbly flows is dominated by bubble wake interactions. Despite the fact that bubble wakes have been investigated intensively in the past, there is still a lack of knowledge about how mass transfer from bubbles is influenced by bubble wake interactions in detail. The scientific scope of this work is to answer the question how bubble wakes are influenced by external flow structures like a vortex street behind a cylinder. For this purpose, the flow field in the vicinity of a single bubble is investigated systematically with high spatial and temporal resolution. High-speed Particle Image Velocimetry (PIV measurements are conducted monitoring the flow structure in the equatorial plane of the single bubble. It is shown that the root mean square (RMS velocity profiles downstream the bubble are influenced significantly by the interaction of vortices. In the presence of a vortex street, the deceleration of the fluid behind the bubble is compensated earlier than in the absence of a vortex street. This happens due to momentum transfer by cross-mixing. Both effects indicate that the interaction of vortices enhances the cross-mixing close to the bubble. Time series of instantaneous velocity fields show the formation of an inner shear layer and coupled vortices. In conclusion, this study shows in detail how the bubble wake is influenced by a vortex street and gives deep insights into possible effects on mixing and mass transfer in bubbly flows.

Structure of positive streamers inside gaseous bubbles immersed in liquids

International Nuclear Information System (INIS)

Babaeva, Natalia Yu; Kushner, Mark J

2009-01-01

Electric discharges and streamers in liquids typically proceed through vapour phase channels produced by the streamer or in gaseous bubbles. The bubbles can originate by enthalpy changes produced by the discharge or can be artificially injected into the liquid. Experiments on streamers in bubbles immersed in liquids have shown that the discharge propagates either along the surface of the bubble or through the volume of the bubble as in conventional streamer propagation in air. In this paper we report on results of a computational investigation of streamer propagation through bubbles immersed in liquids. We found that the dielectric constant of the liquid in large part determines the path the streamer takes. Streamers in bubbles immersed in a liquid with a high permittivity preferentially propagate along the surface of the bubble. Liquids with low permittivity can result in the streamer propagating along the axis of the bubble. The permittivity at which this transition occurs is a function of the applied voltage, size of the bubble and the conductivity of the liquid. (fast track communication)

Simulation of hydrogen bubble growth in tungsten by a hybrid model

International Nuclear Information System (INIS)

Sang, Chaofeng; Sun, Jizhong; Bonnin, Xavier; Wang, L.; Wang, Dezhen

2015-01-01

A two dimensional hybrid code (HIIPC-MC) joining rate-theory and Monte Carlo (MC) methods is developed in this work. We evaluate the cascade-coalescence mechanism contribution to the bubble growth by MC. First, effects of the starting radius and solute deuterium concentration on the bubble growth are studied; then the impacts of the wall temperature and implantation ion flux on the bubble growth are assessed. The simulation indicates that the migration-coalescence of the bubbles and the high pressure inside the bubbles are the main driving forces for the bubble growth, and that neglect of the migration and coalescence would lead to an underestimation of the bubble growth or blistering

Helium bubbles aggravated defects production in self-irradiated copper

Science.gov (United States)

Wu, FengChao; Zhu, YinBo; Wu, Qiang; Li, XinZhu; Wang, Pei; Wu, HengAn

2017-12-01

Under the environment of high radiation, materials used in fission and fusion reactors will internally accumulate numerous lattice defects and bubbles. With extensive studies focused on bubble resolution under irradiation, the mutually effects between helium bubbles and displacement cascades in irradiated materials remain unaddressed. Therefore, the defects production and microstructure evolution under self-irradiation events in vicinity of helium bubbles are investigated by preforming large scale molecular dynamics simulations in single-crystal copper. When subjected to displacement cascades, distinguished bubble resolution categories dependent on bubble size are observed. With the existence of bubbles, radiation damage is aggravated with the increasing bubble size, represented as the promotion of point defects and dislocations. The atomic mechanisms of heterogeneous dislocation structures are attributed to different helium-vacancy cluster modes, transforming from the resolved gas trapped with vacancies to the biased absorption of vacancies by the over-pressured bubble. In both cases, helium impedes the recombination of point defects, leading to the accelerated formation of interstitial loops. The results and insight obtained here might contribute to understand the underlying mechanism of transmutant solute on the long-term evolution of irradiated materials.

A three field two fluid CFD model for the bubbly-cap bubble regime

International Nuclear Information System (INIS)

Martin Lopez de Bertodano; Xiaodong Sun; Mamoru Ishii; Asim Ulke

2005-01-01

Full text of publication follows: The lateral phase distribution of a two phase duct flow in the cap bubble regime is analyzed with a three dimensional three field two-fluid CFD model based on the turbulent k-ε model for bubbly flows developed by Lopez de Bertodano et. al. [2]. The turbulent diffusion of the bubbles is the dominant phase distribution mechanism. A new analytic result is presented to support the development of the model for the bubble induced turbulent diffusion force. New experimental data obtained with a state-of-the-art four sensor miniature conductivity probe are used to validate the two-fluid model. The focus of this work is modeling the transport of the dispersed phase. Previous work (e.g., Lopez de Bertodano et. al.) was focused on the interfacial forces of drag, lift and virtual mass. However, the dispersion of the bubbles by the turbulent eddies of the continuous phase must be considered too. The rigorous formulation of a model for the turbulent dispersion of the bubbles results in a turbulent diffusion force which is obtained from a probability distribution function average (i.e., Boltzmann averaging) of the dispersed phase momentum equation. This force was recently applied to a turbulent bubbly jet with small bubbles (i.e., 1 mm diameter) without adjusting any coefficient. However, the application of this force to industrial conditions (i.e., larger bubbles) requires specific two-phase flow experimental data to calibrate the model due to the uncertainties of the flow around large bubbles. In particular the void distribution and the interfacial area concentration are measured in a mixture of big and small bubbles. The state-of-the-art miniaturized four-sensor conductivity probe developed by Kim et al. [3] is used to obtain the interfacial area concentration in complex two-phase flow situations. This probe can discriminate between small and large bubbles so it offers an opportunity to perform further developments of the multidimensional two

Bubble bath soap poisoning

Science.gov (United States)

... medlineplus.gov/ency/article/002762.htm Bubble bath soap poisoning To use the sharing features on this page, please enable JavaScript. Bubble bath soap poisoning occurs when someone swallows bubble bath soap. ...

Investigation of fast initialization of spacecraft bubble memory systems

Science.gov (United States)

Looney, K. T.; Nichols, C. D.; Hayes, P. J.

1984-01-01

Bubble domain technology offers significant improvement in reliability and functionality for spacecraft onboard memory applications. In considering potential memory systems organizations, minimization of power in high capacity bubble memory systems necessitates the activation of only the desired portions of the memory. In power strobing arbitrary memory segments, a capability of fast turn on is required. Bubble device architectures, which provide redundant loop coding in the bubble devices, limit the initialization speed. Alternate initialization techniques are investigated to overcome this design limitation. An initialization technique using a small amount of external storage is demonstrated.

Visualization of bubble behaviors in forced convective subcooled flow boiling

International Nuclear Information System (INIS)

Inaba, Noriaki; Matsuzaki, Mitsuo; Kikura, Hiroshige; Aritomi, Masanori; Komeno, Toshihiro

2007-01-01

Condensation characteristics of vapor bubble after the departure from a heated section in forced convective subcooled flow boiling were studied visually by using a high speed camera. The purpose of the present study was to measure two-phase flow parameters in subcooled flow boiling. These two-phase flow parameters are void fraction, interfacial area concentration and Sauter mean diameter, which express bubble interface behaviors. The experimental set-up was designed to measure the two-phase flow parameters necessary for developing composite equations for the two fluid models in subcooled flow boiling. In the present experiments, the mass flux, liquid subcooling and the heater were varied within 100-1000kg/m 2 s, 2-10K and 100-300kW/m 2 respectively. Under these experimental conditions, the bubble images were obtained by a high-speed camera, and analyzed paying attention to the condensation of vapor bubbles. These two-phase parameters were obtained by the experimental data, such as the bubble parameter, the bubble volume and the bubble surface. In the calculation process of the two phase flow parameters, it was confirmed that these parameters are related to the void fraction. (author)

The dynamics of a non-equilibrium bubble near bio-materials

International Nuclear Information System (INIS)

Ohl, S W; Klaseboer, E; Khoo, B C

2009-01-01

In many medical treatments oscillating (non-equilibrium) bubbles appear. They can be the result of high-intensity-focused ultrasound, laser treatments or shock wave lithotripsy for example. The physics of such oscillating bubbles is often not very well understood. This is especially so if the bubbles are oscillating near (soft) bio-materials. It is well known that bubbles oscillating near (hard) materials have a tendency to form a high speed jet directed towards the material during the collapse phase of the bubble. It is equally well studied that bubbles near a free interface (air) tend to collapse with a jet directed away from this interface. If the interface is neither 'free' nor 'hard', such as often occurs in bio-materials, the resulting flow physics can be very complex. Yet, in many bio-applications, it is crucial to know in which direction the jet will go (if there is a jet at all). Some applications require a jet towards the tissue, for example to destroy it. For other applications, damage due to impacting jets is to be prevented at all cost. This paper tries to address some of the physics involved in these treatments by using a numerical method, the boundary element method (BEM), to study the dynamics of such bubbles near several bio-materials. In the present work, the behaviour of a bubble placed in a water-like medium near various bio-materials (modelled as elastic fluids) is investigated. It is found that its behaviour depends on the material properties (Young's modulus, Poisson ratio and density) of the bio-material. For soft bio-materials (fat, skin, brain and muscle), the bubble tends to split into smaller bubbles. In certain cases, the resulting bubbles develop opposing jets. For hard bio-materials (cornea, cartilage and bone), the bubble collapses towards the interface with high speed jets (between 100 and about 250 m s -1 ). A summary graph is provided identifying the combined effects of the dimensionless elasticity (κ) and density ratio (α) of

Doppler method leak detection for LMFBR steam generators. Pt. 1. Experimental results of bubble detection using small models

International Nuclear Information System (INIS)

Kumagai, Hiromichi

1999-01-01

To prevent the expansion of the tube damage and to maintain structural integrity in the steam generators (SGs) of fast breeder reactors (FBRs), it is necessary to detect precisely and immediately the leakage of water from heat transfer tubes. Therefore, an active acoustic method was developed. Previous studies have revealed that in practical steam generators the active acoustic method can detect bubbles of 10 l/s within 10 seconds. To prevent the expansion of damage to neighboring tubes, it is necessary to detect smaller leakages of water from the heat transfer tubes. The Doppler method is designed to detect small leakages and to find the source of the leak before damage spreads to neighboring tubes. To evaluate the relationship between the detection sensitivity of the Doppler method and the bubble volume and bubble size, the structural shapes and bubble flow conditions were investigated experimentally, using a small structural model. The results show that the Doppler method can detect the bubbles under bubble flow conditions, and it is sensitive enough to detect small leakages within a short time. The doppler method thus has strong potential for the detection of water leakage in SGs. (author)

The variance of dispersion measure of high-redshift transient objects as a probe of ionized bubble size during reionization

Science.gov (United States)

Yoshiura, Shintaro; Takahashi, Keitaro

2018-01-01

The dispersion measure (DM) of high-redshift (z ≳ 6) transient objects such as fast radio bursts can be a powerful tool to probe the intergalactic medium during the Epoch of Reionization. In this paper, we study the variance of the DMs of objects with the same redshift as a potential probe of the size distribution of ionized bubbles. We calculate the DM variance with a simple model with randomly distributed spherical bubbles. It is found that the DM variance reflects the characteristics of the probability distribution of the bubble size. We find that the variance can be measured precisely enough to obtain the information on the typical size with a few hundred sources at a single redshift.

A derivation of the stable cavitation threshold accounting for bubble-bubble interactions.

Science.gov (United States)

Guédra, Matthieu; Cornu, Corentin; Inserra, Claude

2017-09-01

The subharmonic emission of sound coming from the nonlinear response of a bubble population is the most used indicator for stable cavitation. When driven at twice their resonance frequency, bubbles can exhibit subharmonic spherical oscillations if the acoustic pressure amplitude exceeds a threshold value. Although various theoretical derivations exist for the subharmonic emission by free or coated bubbles, they all rest on the single bubble model. In this paper, we propose an analytical expression of the subharmonic threshold for interacting bubbles in a homogeneous, monodisperse cloud. This theory predicts a shift of the subharmonic resonance frequency and a decrease of the corresponding pressure threshold due to the interactions. For a given sonication frequency, these results show that an optimal value of the interaction strength (i.e. the number density of bubbles) can be found for which the subharmonic threshold is minimum, which is consistent with recently published experiments conducted on ultrasound contrast agents. Copyright © 2017 Elsevier B.V. All rights reserved.

Bubble nucleation in an explosive micro-bubble actuator

International Nuclear Information System (INIS)

Van den Broek, D M; Elwenspoek, M

2008-01-01

Explosive evaporation occurs when a thin layer of liquid reaches a temperature close to the critical temperature in a very short time. At these temperatures spontaneous nucleation takes place. The nucleated bubbles instantly coalesce forming a vapour film followed by rapid growth due to the pressure impulse. In this paper we take a closer look at the bubble nucleation. The moment of bubble nucleation was determined by both stroboscopic imaging and resistance thermometry. Two nucleation regimes could be distinguished. Several different heater designs were investigated under heat fluxes of hundreds of W mm −2 . A close correspondence between current density in the heater and point of nucleation was found. This results in design rules for effective heaters

Nasal continuous positive airway pressure: does bubbling improve gas exchange?

Science.gov (United States)

Morley, C J; Lau, R; De Paoli, A; Davis, P G

2005-07-01

In a randomised crossover trial, 26 babies, treated with Hudson prong continuous positive airway pressure (CPAP) from a bubbling bottle, received vigorous, high amplitude, or slow bubbling for 30 minutes. Pulse oximetry, transcutaneous carbon dioxide, and respiratory rate were recorded. The bubbling rates had no effect on carbon dioxide, oxygenation, or respiratory rate.

Numerical simulation of bubbles motion in lifting pipe of bubble pump for lithium bromide absorption chillers

International Nuclear Information System (INIS)

Gao, Hongtao; Liu, Bingbing; Yan, Yuying

2017-01-01

A bubble pump is proposed to replace the traditional mechanical solution pump in lithium bromide absorption chillers, for its advantageous feature that can be driven by industrial waste heat or solar energy or other low-grade energy. In two-stage bubble pump driven lithium bromide absorption refrigeration system, flow patterns in lifting pipe have significant effects on the performance of bubble pump. In this paper, the single bubble motion and the double bubbles coalescence in vertical ascending pipe are simulated by an improved free energy model of lattice Boltzmann method, in which the two-phase liquid to gas density ratio is 2778. The details of bubbles coalescence process are studied. Density and velocity of bubbles have been obtained. The computational results show that the initial radius of each bubble has a great influence on the coalescence time. The larger the initial bubble radius, the shorter the coalescence time. The pipe diameter has a little effect on the two bubbles coalescence time while it has a significant effect on the bubble velocity. As the pipe diameter increases, the bubble velocity increases. The obtained results are helpful for studying the transition mechanisms of two-phase flow patterns and useful for improving the bubble pump performance by controlling the flow patterns in lifting pipe.

HCDA bubble experiment, (2)

International Nuclear Information System (INIS)

Sakata, Kaoru; Mashiko, Hiroyuki; Oka, Yoshiaki; An, Shigehiro; Isozaki, Tadashi.

1981-06-01

An experiment simulating the behavior of the very large steam bubbles generated at the time of an accident of core collapse was carried out with a warm water tank, and the applicability of the theory of very small bubble disappearance known at present was examined. The bubbles generated in HCDA (hypothetical core disruptive accident) are expected to be very large, containing sodium, fuel, FP gas and so on, and play important role in the mechanism of emitting radioactive substances in the safety analysis of LMFBRs. In this experiment, the degree of subcool of the warm water pool, the initial radii of steam bubbles and the blowoff pressure of steam were taken as the parameters. The radius of the steam bubbles generated in the experiment was about 6.5 cm, and the state of disappearance was different above and below the degree of unsaturation of 10 deg C. Comparing the disappearance curve obtained by the experiment with the theory of disappearance of small bubbles, the experimental values were between inertia-controlled disappearance and heat transfer-controlled disappearance, and this result was able to be explained generally with the model taking the pressure change within steam bubbles into account. The rise of bubbles was also observed. (Kako, I.)

Optimization of the bubble radius in a moving single bubble sonoluminescence

International Nuclear Information System (INIS)

Mirheydari, Mona; Sadighi-Bonabi, Rasoul; Rezaee, Nastaran; Ebrahimi, Homa

2011-01-01

A complete study of the hydrodynamic force on a moving single bubble sonoluminescence in N-methylformamide is presented in this work. All forces exerted, trajectory, interior temperature and gas pressure are discussed. The maximum values of the calculated components of the hydrodynamic force for three different radii at the same driving pressure were compared, while the optimum bubble radius was determined. The maximum value of the buoyancy force appears at the start of bubble collapse, earlier than the other forces whose maximum values appear at the moment of bubble collapse. We verified that for radii larger than the optimum radius, the temperature peak value decreases.

Bubble nonlinear dynamics and stimulated scattering process

Science.gov (United States)

Jie, Shi; De-Sen, Yang; Sheng-Guo, Shi; Bo, Hu; Hao-Yang, Zhang; Shi-Yong, Hu

2016-02-01

A complete understanding of the bubble dynamics is deemed necessary in order to achieve their full potential applications in industry and medicine. For this purpose it is first needed to expand our knowledge of a single bubble behavior under different possible conditions including the frequency and pressure variations of the sound field. In addition, stimulated scattering of sound on a bubble is a special effect in sound field, and its characteristics are associated with bubble oscillation mode. A bubble in liquid can be considered as a representative example of nonlinear dynamical system theory with its resonance, and its dynamics characteristics can be described by the Keller-Miksis equation. The nonlinear dynamics of an acoustically excited gas bubble in water is investigated by using theoretical and numerical analysis methods. Our results show its strongly nonlinear behavior with respect to the pressure amplitude and excitation frequency as the control parameters, and give an intuitive insight into stimulated sound scattering on a bubble. It is seen that the stimulated sound scattering is different from common dynamical behaviors, such as bifurcation and chaos, which is the result of the nonlinear resonance of a bubble under the excitation of a high amplitude acoustic sound wave essentially. The numerical analysis results show that the threshold of stimulated sound scattering is smaller than those of bifurcation and chaos in the common condition. Project supported by the Program for Changjiang Scholars and Innovative Research Team in University, China (Grant No. IRT1228) and the Young Scientists Fund of the National Natural Science Foundation of China (Grant Nos. 11204050 and 11204049).

DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects.

Science.gov (United States)

Polesello, Vania; Zupin, Luisa; Di Lenarda, Roberto; Biasotto, Matteo; Pozzato, Gabriele; Ottaviani, Giulia; Gobbo, Margherita; Crovella, Sergio; Segat, Ludovica

2017-01-01

The aetiology of Oral Lichen Planus (OLP), a chronic inflammatory disease of oral mucosa, is not yet well understood. Since innate immunity may be hypothesized as involved in the susceptibility to OLP, we studied human beta defensin 1 (hBD-1) an antimicrobial peptide constitutively expressed in the saliva, looking at functional genetic variants possibly able to diminish hBD-1 production an consequently conferring major susceptibility to OLP. We analysed three DEFB1 polymorphisms at 5' UTR, -52G>A (rs1799946), -44C>G (rs1800972), -20G>A (rs11362) and two DEFB1 polymorphisms at 3'UTR, c*5G>A (rs1047031), c*87A>G (rs1800971), with the aim of correlating these genetic variants and hBD-1 salivary level in a group of OLP patients and in healthy subjects. We also evaluated hBD-1 salivary concentrations, using ELISA, in OLP and healthy controls. We compared hBD-1 concentrations in OLP and healthy subjects: hBD-1 concentration was significantly higher in OLP patients respect to control. When considering the correlation between DEFB1 polymorphisms genotypes and hBD-1 expression levels, significant results were obtained for SNPs -52G>A (p=0.03 both in OLP patients and healthy individuals) and -44C>G (p=0.02 in OLP patients). hBD-1 production was different between OLP and healthy subjects (not age-matched with OLP). DEFB1 gene polymorphisms, -52G>A and -44C>G, correlated with hBD-1 salivary concentrations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Development of three-dimensional individual bubble-velocity measurement method by bubble tracking

International Nuclear Information System (INIS)

Kanai, Taizo; Furuya, Masahiro; Arai, Takahiro; Shirakawa, Kenetsu; Nishi, Yoshihisa

2012-01-01

A gas-liquid two-phase flow in a large diameter pipe exhibits a three-dimensional flow structure. Wire-Mesh Sensor (WMS) consists of a pair of parallel wire layers located at the cross section of a pipe. Both the parallel wires cross at 90o with a small gap and each intersection acts as an electrode. The WMS allows the measurement of the instantaneous two-dimensional void-fraction distribution over the cross-section of a pipe, based on the difference between the local instantaneous conductivity of the two-phase flow. Furthermore, the WMS can acquire a phasic-velocity on the basis of the time lag of void signals between two sets of WMS. Previously, the acquired phasic velocity was one-dimensional with time-averaged distributions. The authors propose a method to estimate the three-dimensional bubble-velocity individually WMS data. The bubble velocity is determined by the tracing method. In this tracing method, each bubble is separated from WMS signal, volume and center coordinates of the bubble is acquired. Two bubbles with near volume at two WMS are considered as the same bubble and bubble velocity is estimated from the displacement of the center coordinates of the two bubbles. The validity of this method is verified by a swirl flow. The proposed method can successfully visualize a swirl flow structure and the results of this method agree with the results of cross-correlation analysis. (author)

An experimental study of particle-bubble interaction and attachment in flotation

KAUST Repository

Sanchez Yanez, Aaron

2017-05-01

The particle-bubble interaction is found in industrial applications with the purpose of selective separation of materials especially in the mining industry. The separation is achieved with the use of bubbles that collect particles depending on their hydrophobicity. There are few experimental studies involving a single interaction between a bubble and a particle. The purpose of this work is to understand this interaction by the study of a single bubble interacting with a single particle. Experiments were conducted using ultra-pure water, glass particles and air bubbles. Single interactions of particles with bubbles were observed using two high speed cameras. The cameras were placed perpendicular to each other allowing to reconstruct the three-dimensional position of the particle, the bubble and the particle-bubble aggregate. A single size of particle was used varying the size for the bubbles. It was found that the attachment of a particle to a bubble depends on its degree of hydrophobicity and on the relative position of the particle and the bubble before they encounter.

Electric fields effect on the rise of single bubbles during boiling

International Nuclear Information System (INIS)

Siedel, Samuel; Cioulachtjian, Serge; Bonjour, Jocelyn

2009-01-01

An experimental study of saturated pool boiling on a single artificial nucleation site without and with the application of an electric field on the boiling surface has been conducted. N-pentane is boiling on a copper surface and is recorded with a high speed camera providing high quality pictures and movies. The accuracy of the visualization allowed establishing an experimental bubble growth law from a large number of experiments. This law shows that the evaporation rate is decreasing during the bubble growth, and underlines the importance of liquid motion induced by the preceding bubble. Bubble rise is therefore studied: once detached, bubbles accelerate vertically until reaching a maximum velocity in good agreement with a correlation from literature. The bubbles then turn to another direction. The effect of applying an electric field on the boiling surface in finally studied. In addition to changes of the bubble shape, changes are also shown in the liquid plume and the convective structures above the surface. Lower maximum rising velocities were measured in the presence of electric fields, especially with a negative polarity. (author)

Effect of chloride substitution on the order–disorder transition in NaBH{sub 4} and Na{sup 11}BD{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Olsen, Jørn Eirik [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Karen, Pavel [University of Oslo, Department of Chemistry, P.O. Box 1033 Blindern, NO-0315 Oslo (Norway); Sørby, Magnus H. [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Hauback, Bjørn C., E-mail: bjorn.hauback@ife.no [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway)

2014-02-25

Graphical abstract: Interactions that order the BD{sub 4}{sup -} tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH{sub 4}){sub 1−x}Cl{sub x} and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na{sup 11}BD{sub 4} at room temperature and 8 K and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na{sup 11}BD{sub 4} (NaBH{sub 4}) and its solid solutions with NaCl, Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x}, is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na{sup 11}BD{sub 4}, ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na{sup 11}BD{sub 4}) at 8 K.

Interaction of a vortex ring and a bubble

Science.gov (United States)

Jha, Narsing K.; Govardhan, Raghuraman N.

2014-11-01

Micro-bubble injection in to boundary layers is one possible method for reducing frictional drag of ships. Although this has been studied for some time, the physical mechanisms responsible for drag reduction using microbubbles in turbulent boundary layers is not yet fully understood. Previous studies suggest that bubble-vortical structure interaction seems to be one of the important physical mechanisms for frictional drag reduction using microbubbles. In the present work, we study a simplification of this problem, namely, the interaction of a single vortical structure, in particular a vortex ring, with a single bubble for better understanding of the physics. The vortex ring is generated using a piston-cylinder arrangement and the bubble is generated by connecting a capillary to an air pump. The bubble dynamics is directly visualized using a high speed camera, while the vorticity modification is measured using time resolved PIV. The results show that significant deformations can occur of both the bubble and the vortex ring. Effect of different non-dimensional parameters on the interaction will be presented in the meeting.

Two-fluid model LES of a bubble column

International Nuclear Information System (INIS)

Brahma N Reddy Vanga; Martin A Lopez de Bertodano; Eckhard Krepper; Alexandr Zaruba; Horst-Michael Prasser

2005-01-01

The hydrodynamics of a rectangular bubble column operating in the dispersed bubbly regime has been numerically investigated using a two-fluid model Large Eddy Simulation (LES). Experimental data were obtained to validate the model. LES computational fluid dynamic calculations of the transient flow for the bubble column were performed to account for the turbulence in the liquid phase. The computational mesh is of the same scale as the bubble size. The sub grid-scale Reynolds stresses were calculated with the Smagorinsky model. Furthermore, the effect of the bubbles on the turbulence in the continuous phase was modeled using Sato's eddy viscosity model for bubble-induced turbulence. Mean quantities were computed by averaging over a time period that was longer than the dynamic time scales of the turbulence, in particular the void fraction and the average velocity of the bubbles. A systematic analysis of the effect of the interfacial momentum transfer terms on these quantities has been conducted. The bubble column was locally aerated using a sparger located in the center of the bottom plate. The experimental studies involve wire-mesh tomography measurements for void fraction and bubble size distributions and digital image processing of high speed camera images for estimation of bubble velocities, size distributions and flow patterns. Experiments were performed for various aspect ratios (height of water column to width ratio) and superficial gas velocities. It was found that the non-drag bubble forces play a very prominent role in the predicting the correct flow pattern and void fraction distributions. In the calculations, the lift force and the wall force were considered. A 'wall peak' in the time averaged void fraction distribution has been experimentally observed and this cannot be predicted without including these non-drag forces in the numerical calculations. In this paper, experimental data are compared with the results of the numerical simulations. (authors)

Acoustic waves in polydispersed bubbly liquids

International Nuclear Information System (INIS)

Gubaidullin, D A; Gubaidullina, D D; Fedorov, Yu V

2014-01-01

The propagation of acoustic waves in polydispersed mixtures of liquid with two sorts of gas bubbles each of which has its own bubble size distribution function is studied. The system of the differential equations of the perturbed motion of a mixture is presented, the dispersion relation is obtained. Equilibrium speed of sound, low-frequency and high-frequency asymptotes of the attenuation coefficient are found. Comparison of the developed theory with known experimental data is presented

Acoustic waves in polydispersed bubbly liquids

Science.gov (United States)

Gubaidullin, D. A.; Gubaidullina, D. D.; Fedorov, Yu V.

2014-11-01

The propagation of acoustic waves in polydispersed mixtures of liquid with two sorts of gas bubbles each of which has its own bubble size distribution function is studied. The system of the differential equations of the perturbed motion of a mixture is presented, the dispersion relation is obtained. Equilibrium speed of sound, low-frequency and high-frequency asymptotes of the attenuation coefficient are found. Comparison of the developed theory with known experimental data is presented.

Jets from pulsed-ultrasound-induced cavitation bubbles near a rigid boundary

Science.gov (United States)

Brujan, Emil-Alexandru

2017-06-01

The dynamics of cavitation bubbles, generated from short (microsecond) pulses of ultrasound and situated near a rigid boundary, are investigated numerically. The temporal development of the bubble shape, bubble migration, formation of the liquid jet during bubble collapse, and the kinetic energy of the jet are investigated as a function of the distance between bubble and boundary. During collapse, the bubble migrates towards the boundary and the liquid jet reaches a maximum velocity between 80 m s-1 and 120 m s-1, depending on the distance between bubble and boundary. The conversion of bubble energy to kinetic energy of the jet ranges from 16% to 23%. When the bubble is situated in close proximity to the boundary, the liquid jet impacts the boundary with its maximum velocity, resulting in an impact pressure of the order of tens of MPa. The rapid expansion of the bubble, the impact of the liquid jet onto the nearby boundary material, and the high pressure developed inside the bubble at its minimum volume can all contribute to the boundary material damage. The high pressure developed during the impact of the liquid jet onto the biological material and the shearing forces acting on the material surface as a consequence of the radial flow of the jet outward from the impact site are the main damage mechanisms of rigid biological materials. The results are discussed with respect to cavitation damage of rigid biological materials, such as disintegration of renal stones and calcified tissue and collateral effects in pulsed ultrasound surgery.

Jets from pulsed-ultrasound-induced cavitation bubbles near a rigid boundary

International Nuclear Information System (INIS)

Brujan, Emil-Alexandru

2017-01-01

The dynamics of cavitation bubbles, generated from short (microsecond) pulses of ultrasound and situated near a rigid boundary, are investigated numerically. The temporal development of the bubble shape, bubble migration, formation of the liquid jet during bubble collapse, and the kinetic energy of the jet are investigated as a function of the distance between bubble and boundary. During collapse, the bubble migrates towards the boundary and the liquid jet reaches a maximum velocity between 80 m s −1 and 120 m s −1 , depending on the distance between bubble and boundary. The conversion of bubble energy to kinetic energy of the jet ranges from 16% to 23%. When the bubble is situated in close proximity to the boundary, the liquid jet impacts the boundary with its maximum velocity, resulting in an impact pressure of the order of tens of MPa. The rapid expansion of the bubble, the impact of the liquid jet onto the nearby boundary material, and the high pressure developed inside the bubble at its minimum volume can all contribute to the boundary material damage. The high pressure developed during the impact of the liquid jet onto the biological material and the shearing forces acting on the material surface as a consequence of the radial flow of the jet outward from the impact site are the main damage mechanisms of rigid biological materials. The results are discussed with respect to cavitation damage of rigid biological materials, such as disintegration of renal stones and calcified tissue and collateral effects in pulsed ultrasound surgery. (paper)

Gas fluxing of aluminum: a bubble probe for optimization of bubbles/bubble distribution and minimization of splashing/droplet formation

International Nuclear Information System (INIS)

James W. Evans; Auitumn Fjeld

2006-01-01

totaling 1.549 million lbs. for only thirteen of the twenty three primary smelters then in operation in the US. The research work described in the body of this report (the doctoral dissertation of Dr. Autumn M. Fjeld) had as its objective the improvement of gas fluxing technology to reduce emissions while still maintaining fluxing unit metal throughput. A second objective was a better understanding of the splashing and droplet emission that occurs during fluxing at high gas throughput rates. In the extreme such droplets can form undesired accretions on the walls and gas exit lines of the fluxing unit. Consequently, the productivity of a fluxing unit is sometimes limited by the need to avoid such spraying of droplets produced as gas bubbles break at the metal surface. The approach used was a combination of experimental work in laboratories at UC Berkeley and at the Alcoa Technical Center. The experimental work was mostly on a bubble probe that could be used to determine the extent of dispersion of gas bubbles in the fluxing unit (a parameter affecting the utilization of the injected chlorine). Additionally a high speed digital movie camera was used to study droplet formation due to gas bubbles bursting at the surface of a low melting point alloy. The experimental work was supported by mathematical modeling. In particular, two FLUENT? base mathematical models were developed to compute the metal flow and distribution of the gas within a fluxing unit. Results from these models were then used in a third model to compute emissions and the progress of impurity removal as a function of parameters such as rotor speed. The project was successful in demonstrating that the bubble probe could detect bubbles in a gas fluxing unit at the Alcoa technical Center outside Pittsburgh, PA. This unit is a commercial sized one and the probe, with its associated electronics, was subjected to the hostile molten aluminum, electrical noise etc. Despite this the probes were, on several occasions

Visualization study of film drops produced by bubble bursting

International Nuclear Information System (INIS)

Ma Chao; Bo Hanliang

2012-01-01

The phenomenon that bubble bursting results in drops production is common in the steam generator of the nuclear power plant, and the fine drops generated by this way is one of the most important source of the drop entrainment in the vapor stream. The visualization experiment about the film drops produced by the bursting bubbles at a free water surface was studied using a high-speed video camera. The results show that the bubble cap breaks up in a single point, within the limits of bubble size in the experiment at present. The whole process can be distinguished into four successive stages: A primary inertial drainage, the bubble cap puncture at the foot or on the top, the film rolls-up and the liquid ring appearing with the hole expanding, and fine film drops emission under the effect of destabilization of a Rayleigh-Taylor type. The expression about the bubble radius and the film drops number is obtain by fitting the experiment data at the bubble radius range from 3-25 mm. The result trend agrees well with the previous work. (authors)

Collapse of a cavitation bubble generated by low voltage discharge in water

Directory of Open Access Journals (Sweden)

Zima Patrik

2012-04-01

Full Text Available The article presents experimental results of the optical study of cavitation bubble collapse close to a solid boundary in water. The bubble was generated by discharge of two low-voltage capacitors. High-speed CCD camera was used to record the time evolution of the bubble size. High-power halogen lamp was used for illumination. The system was synchronized by pulse generator connected to an oscilloscope. The velocity of the re-entrant jet was estimated from the time resolved photography for different maximum bubble sizes.

Developmental changes in hypothalamic oxytocin and oxytocin receptor mRNA expression and their sensitivity to fasting in male and female rats.

Science.gov (United States)

Matsuzaki, Toshiya; Iwasa, Takeshi; Munkhzaya, Munkhsaikhan; Tungalagsuvd, Altankhuu; Kawami, Takako; Murakami, Masahiro; Yamasaki, Mikio; Yamamoto, Yuri; Kato, Takeshi; Kuwahara, Akira; Yasui, Toshiyuki; Irahara, Minoru

2015-04-01

Oxytocin (OT) affects the central nervous system and is involved in a variety of social and non-social behaviors. Recently, the role played by OT in energy metabolism and its organizational effects on estrogen receptor alpha (ER-α) during the neonatal period have gained attention. In this study, the developmental changes in the hypothalamic mRNA levels of OT, the OT receptor (OTR), and ER-α were evaluated in male and female rats. In addition, the fasting-induced changes in the hypothalamic mRNA levels of OT and the OTR were evaluated. Hypothalamic explants were taken from postnatal day (PND) 10, 20, and 30 rats, and the mRNA level of each molecule was measured. Hypothalamic OT mRNA expression increased throughout the developmental period in both sexes. The rats' hypothalamic OTR mRNA levels were highest on PND 10 and decreased throughout the developmental period. In the male rats, the hypothalamic mRNA levels of ER-α were higher on PND 30 than on PND 10. On the other hand, no significant differences in hypothalamic ER-α mRNA expression were detected among the examined time points in the female rats, although hypothalamic ER-α mRNA expression tended to be higher on PND 30 than on PND 10. Significant positive correlations were detected between hypothalamic OT and ER-α mRNA expression in both the male and female rats. Hypothalamic OT mRNA expression was not affected by fasting at any of the examined time points in either sex. These results indicate that hypothalamic OT expression is not sensitive to fasting during the developmental period. In addition, as a positive correlation was detected between hypothalamic OT and ER-α mRNA expression, these two molecules might interact with each other to induce appropriate neuronal development. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dynamics of bubble-bubble interaction in sheared low-viscosity magma imaged by X-ray computed micro-tomography

Science.gov (United States)

Helo, C.; Flaws, A.; Hess, K.-U.; Franz, A.; Clague, D. A.; Dingwell, D. B.

2012-04-01

X-ray computed tomography of vesicles in basaltic pyroclastic glass fragments has been used to investigate the syn-eruptive shear environment and resulting bubble-bubble interaction during mild pyroclastic eruptions in a mid-ocean ridge environment. We have imaged vesicles present in two different types of pyroclastic fragments produced by mildly explosive activity on Axial Seamount, limu o Pele, that is, thin glass films often described as bubble walls, and tube scoria fragments. Rapid quenching of the glass has prevented extensive bubble relaxation preserving the syn-eruptive geometry of the bubbles in these fragments. Isolated, ellipsoid-shaped vesicles in low-vesicular limu o Pele indicate deformation in a simple shear environment. Under these shear conditions higher vesiculated parts of the erupting magma show strong bubble-bubble interactions partially leading to coalscence and formation of tubular vesicles. These tubular vesicles can reach significant lengths, exceeding the dimensions of the small glass fragments (2 mm). Their unreformed radius can be more then one order of magnitude larger than that of the isolated vesicles in the limu o Pele fragments. We can distinguish two principle modes of interaction based on the relative orientation of the bubbles. Interaction along the sidewalls of two bubbles, and tip-to-tip interaction. At interdistances of less than a few tens of micrometre, interaction of the sidewalls results in deformation of the bubbles to more irregular shapes, with depressions caused by close, small bubbles or in some cases bubbles being partially mantled around tubular bubbles. This often leads to a more close packing of bubbles. At distances of less than a few microns, the melt films between the bubbles destabilize leading to coalescence. This mechanism appears to involve a bulging of the larger bubble into the smaller, followed by melt film rapture and coalescence. The complete digestion of one bubble by the other is the slow rate

Use of an ultrasonic reflectance technique to examine bubble size changes in dough

Science.gov (United States)

Strybulevych, A.; Leroy, V.; Shum, A. L.; Koksel, H. F.; Scanlon, M. G.; Page, J. H.

2012-12-01

Bread quality largely depends on the manner in which bubbles are created and manipulated in the dough during processing. We have developed an ultrasonic reflectance technique to monitor bubbles in dough, even at high volume fractions, where near the bubble resonances it is difficult to make measurements using transmission techniques. A broadband transducer centred at 3.5 MHz in a normal incidence wave reflection set-up is used to measure longitudinal velocity and attenuation from acoustic impedance measurements. The technique is illustrated by examining changes in bubbles in dough due to two very different physical effects. In dough made without yeast, a peak in attenuation due to bubble resonance is observed at approximately 2 MHz. This peak diminishes rapidly and shifts to lower frequencies, indicative of Ostwald ripening of bubbles within the dough. The second effect involves the growth of bubble sizes due to gas generated by yeast during fermentation. This process is experimentally challenging to investigate with ultrasound because of very high attenuation. The reflectance technique allows the changes of the velocity and attenuation during fermentation to be measured as a function of frequency and time, indicating bubble growth effects that can be monitored even at high volume fractions of bubbles.

Use of an ultrasonic reflectance technique to examine bubble size changes in dough

International Nuclear Information System (INIS)

Strybulevych, A; Leroy, V; Page, J H; Shum, A L; Koksel, H F; Scanlon, M G

2012-01-01

Bread quality largely depends on the manner in which bubbles are created and manipulated in the dough during processing. We have developed an ultrasonic reflectance technique to monitor bubbles in dough, even at high volume fractions, where near the bubble resonances it is difficult to make measurements using transmission techniques. A broadband transducer centred at 3.5 MHz in a normal incidence wave reflection set-up is used to measure longitudinal velocity and attenuation from acoustic impedance measurements. The technique is illustrated by examining changes in bubbles in dough due to two very different physical effects. In dough made without yeast, a peak in attenuation due to bubble resonance is observed at approximately 2 MHz. This peak diminishes rapidly and shifts to lower frequencies, indicative of Ostwald ripening of bubbles within the dough. The second effect involves the growth of bubble sizes due to gas generated by yeast during fermentation. This process is experimentally challenging to investigate with ultrasound because of very high attenuation. The reflectance technique allows the changes of the velocity and attenuation during fermentation to be measured as a function of frequency and time, indicating bubble growth effects that can be monitored even at high volume fractions of bubbles.

High-resolution recording of particle tracks with in-line holography in a large cryogenic bubble chamber

CERN Document Server

Harigel, G G

2000-01-01

Holography has been used successfully in combination with conventional optics for the first time in a large cryogenic bubble chamber, the 15-Foot Bubble Chamber at the Fermi National Accelerator Laboratory (FNAL), during a physics run in a high-energy neutrino beam. The innovative system combined the reference beam with the object beam, irradiating a conical volume of ~1.5 m/sup 3/. Bubble tracks from neutrino interactions with a width of ~120 mu m have been recorded with good contrast. The ratio of intensities of the object light to the reference light striking the film is called the beam branching ratio (BBR). We obtained in our experiment an exceedingly small minimum-observable ratio of BBR=(0.54/0.21)*10/sup -7/. The technology has the potential for a wide range of applications. This paper describes the various difficulties in achieving the success. It required the development of laser pulse stretching via enhanced closed loop control with slow Q-switching, to overcome excessive heating of the cryogenic l...

BD-22deg3467, a DAO-type Star Exciting the Nebula Abell 35

Science.gov (United States)

Ziegler, M.; Rauch, T.; Werner, K.; Koppen, J.; Kruk, J. W.

2013-01-01

Spectral analyses of hot, compact stars with non-local thermodynamical equilibrium (NLTE) model-atmosphere techniques allow the precise determination of photospheric parameters such as the effective temperature (T(sub eff)), the surface gravity (log g), and the chemical composition. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Aims. Previous spectral analyses of the exciting star of the nebula A35, BD-22deg3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. We aim to identify all observed lines in the ultraviolet (UV) spectrum of BD-22deg3467 and to determine the abundances of the respective species precisely. Methods. For the analysis of high-resolution and high signal-to-noise ratio (S/N) far-ultraviolet (FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. Results. The best agreement with the UV observation of BD-22deg3467 is achieved at T(sub eff) = 80 +/- 10 kK and log g = 7.2 +/- 0.3. While T(sub eff) of previous analyses is verified, log g is significantly lower. We re-analyzed lines of silicon and iron (1/100 and about solar abundances, respectively) and for the first time in this star identified argon, chromium, manganese, cobalt, and nickel and determined abundances of 12, 70, 35, 150, and 5 times solar, respectively. Our results partially agree with predictions of diffusion models for DA-type white dwarfs. A combination of photospheric and interstellar line-absorption models reproduces more than 90% of the observed absorption features. The stellar mass is M approx. 0.48 Solar Mass. Conclusions. BD.22.3467 may not have been massive enough to ascend the asymptotic giant branch and may have evolved directly from the extended horizontal branch

Correction of bubble size distributions from transmission electron microscopy observations

International Nuclear Information System (INIS)

Kirkegaard, P.; Eldrup, M.; Horsewell, A.; Skov Pedersen, J.

1996-01-01

Observations by transmission electron microscopy of a high density of gas bubbles in a metal matrix yield a distorted size distribution due to bubble overlap and bubble escape from the surface. A model is described that reconstructs 3-dimensional bubble size distributions from 2-dimensional projections on taking these effects into account. Mathematically, the reconstruction is an ill-posed inverse problem, which is solved by regularization technique. Extensive Monte Carlo simulations support the validity of our model. (au) 1 tab., 32 ills., 32 refs

Colliding with a crunching bubble

Energy Technology Data Exchange (ETDEWEB)

Freivogel, Ben; Freivogel, Ben; Horowitz, Gary T.; Shenker, Stephen

2007-03-26

In the context of eternal inflation we discuss the fate of Lambda = 0 bubbles when they collide with Lambda< 0 crunching bubbles. When the Lambda = 0 bubble is supersymmetric, it is not completely destroyed by collisions. If the domain wall separating the bubbles has higher tension than the BPS bound, it is expelled from the Lambda = 0 bubble and does not alter its long time behavior. If the domain wall saturates the BPS bound, then it stays inside the Lambda = 0 bubble and removes a finite fraction of future infinity. In this case, the crunch singularity is hidden behind the horizon of a stable hyperbolic black hole.

Inertial manipulation of bubbles in rectangular microfluidic channels.

Science.gov (United States)

Hadikhani, Pooria; Hashemi, S Mohammad H; Balestra, Gioele; Zhu, Lailai; Modestino, Miguel A; Gallaire, François; Psaltis, Demetri

2018-03-27

Inertial microfluidics is an active field of research that deals with crossflow positioning of the suspended entities in microflows. Until now, the majority of the studies have focused on the behavior of rigid particles in order to provide guidelines for microfluidic applications such as sorting and filtering. Deformable entities such as bubbles and droplets are considered in fewer studies despite their importance in multiphase microflows. In this paper, we show that the trajectory of bubbles flowing in rectangular and square microchannels can be controlled by tuning the balance of forces acting on them. A T-junction geometry is employed to introduce bubbles into a microchannel and analyze their lateral equilibrium position in a range of Reynolds (1 < Re < 40) and capillary numbers (0.1 < Ca < 1). We find that the Reynolds number (Re), the capillary number (Ca), the diameter of the bubble (D[combining macron]), and the aspect ratio of the channel are the influential parameters in this phenomenon. For instance, at high Re, the flow pushes the bubble towards the wall while large Ca or D[combining macron] moves the bubble towards the center. Moreover, in the shallow channels, having aspect ratios higher than one, the bubble moves towards the narrower sidewalls. One important outcome of this study is that the equilibrium position of bubbles in rectangular channels is different from that of solid particles. The experimental observations are in good agreement with the performed numerical simulations and provide insights into the dynamics of bubbles in laminar flows which can be utilized in the design of flow based multiphase flow reactors.

Cloning and analysis of the full-length cDNA of reindeer β-defensin caBD-1%驯鹿β-防御素reBD-1全长cDNA的克隆及序列分析

Institute of Scientific and Technical Information of China (English)

杨银凤; 郝永峰; 赵艳芳; 余兴帮; 都格尔斯仁

2008-01-01

为了获得驯鹿β-防御素reBD-1全长cDNA序列,根据已获得的reBD-1 cDNA的已知序列设计1条序列特异性引物作为上游引物,反转录引物中的部分序列即3′接舍器引物作为下游引物,克隆reBD-1 cDNA的3′末端序列.另外,采用反向嵌套PCR RACE法,根据reBD-1 cDNA的已知序列,设计1条5′末端磷酸化的特异性反转录引物和2对特异性反向嵌套PCR引物,首先进行反转录(RT),然后将mRNA反转录成的cDNA进行环化,最后进行反向嵌套巢式PCR,克隆reBD-1 cDNA的5′末端序列.结果成功的克隆出了reBD-1 cDNA的3′和5′末端序列,从而得到372 bp的reBD-1 cDNA全序列,其中包含44 bp 5′非翻译区(UTR)、192 bp的开放读码框(ORF)、终止密码子TAA、118 bp的3′UTR和poly(A)15.reBD-1 cDNA全序列的获得为进一步研究其基因结构、基因表达和基因功能奠定了基础.

Influence of centrifugation conditions on the results of 77 routine clinical chemistry analytes using standard vacuum blood collection tubes and the new BD-Barricor tubes.

Science.gov (United States)

Cadamuro, Janne; Mrazek, Cornelia; Leichtle, Alexander B; Kipman, Ulrike; Felder, Thomas K; Wiedemann, Helmut; Oberkofler, Hannes; Fiedler, Georg M; Haschke-Becher, Elisabeth

2018-02-15

Although centrifugation is performed in almost every blood sample, recommendations on duration and g-force are heterogeneous and mostly based on expert opinions. In order to unify this step in a fully automated laboratory, we aimed to evaluate different centrifugation settings and their influence on the results of routine clinical chemistry analytes. We collected blood from 41 healthy volunteers into BD Vacutainer PST II-heparin-gel- (LiHepGel), BD Vacutainer SST II-serum-, and BD Vacutainer Barricor heparin-tubes with a mechanical separator (LiHepBar). Tubes were centrifuged at 2000xg for 10 minutes and 3000xg for 7 and 5 minutes, respectively. Subsequently 60 and 21 clinical chemistry analytes were measured in plasma and serum samples, respectively, using a Roche COBAS instrument. High sensitive Troponin T, pregnancy-associated plasma protein A, ß human chorionic gonadotropin and rheumatoid factor had to be excluded from statistical evaluation as many of the respective results were below the measuring range. Except of free haemoglobin (fHb) measurements, no analyte result was altered by the use of shorter centrifugation times at higher g-forces. Comparing LiHepBar to LiHepGel tubes at different centrifugation setting, we found higher lactate-dehydrogenase (LD) (P = 0.003 to centrifuged at higher speed (3000xg) for a shorter amount of time (5 minutes) without alteration of the analytes tested in this study. When using LiHepBar tubes for blood collection, a separate LD reference value might be needed.

Gas bubble disease monitoring and research of juvenile salmonids

International Nuclear Information System (INIS)

Maule, A.G.; Beeman, J.; Hans, K.M.; Mesa, M.G.; Haner, P.; Warren, J.J.

1997-10-01

This document describes the project activities 1996--1997 contract year. This report is composed of three chapters which contain data and analyses of the three main elements of the project: field research to determine the vertical distribution of migrating juvenile salmonids, monitoring of juvenile migrants at dams on the Snake and Columbia rivers, and laboratory experiments to describe the progression of gas bubble disease signs leading to mortality. The major findings described in this report are: A miniature pressure-sensitive radio transmitter was found to be accurate and precise and, after compensation for water temperature, can be used to determine the depth of tagged-fish to within 0.32 m of the true depth (Chapter 1). Preliminary data from very few fish suggest that depth protects migrating juvenile steelhead from total dissolved gas supersaturation (Chapter 1). As in 1995, few fish had any signs of gas bubble disease, but it appeared that prevalence and severity increased as fish migrated downstream and in response to changing gas supersaturation (Chapter 2). It appeared to gas bubble disease was not a threat to migrating juvenile salmonids when total dissolved gas supersaturation was < 120% (Chapter 2). Laboratory studies suggest that external examinations are appropriate for determining the severity of gas bubble disease in juvenile salmonids (Chapter 3). The authors developed a new method for examining gill arches for intravascular bubbles by clamping the ventral aorta to reduce bleeding when arches were removed (Chapter 3). Despite an outbreak of bacterial kidney disease in the experimental fish, the data indicate that gas bubble disease is a progressive trauma that can be monitored (Chapter 3)

Bubble nucleation of R134A refrigerant in a pressurized flow boiling system

Energy Technology Data Exchange (ETDEWEB)

Murshed, S.M. Sohel; Vereen, Keon; Kumar, Ranganathan [University of Central Florida, Orlando, FL (United States). Dept. of Mechanical, Materials and Aerospace Engineering], e-mail: rnkumar@mail.ucf.edu

2009-07-01

The effect of heat flux and pressure on bubble nucleation of R134a refrigerant in a flow boiling system is experimentally studied. An experimental facility was built and an innovative concept of thermochromic liquid crystal (TLC) technique was introduced for the high resolution and accurate measurement of the overall heater surface temperature. The visualization and image recording process is performed by employing two synchronized high resolution and high speed cameras which simultaneously capture colored TLC images as well as bubble nucleation activities at high frame rates. Experiments were conducted at different high pressures ranging from 690 to 830 kPa and at different heat flux conditions in order to identify their influence on flow boiling performance specially bubbling event. Present results demonstrate that both the heat flux and pressure influence the bubble generation rate and size. For example, bubble generation frequency and size are found to increase with heat flux. An increase in pressure of 137 kPa (from 690 to 827 kPa) increased the bubble frequency and size about 32 Hz and 20 {mu}m, respectively. (author)

Bubble nucleation of R134A refrigerant in a pressurized flow boiling system

International Nuclear Information System (INIS)

Murshed, S.M. Sohel; Vereen, Keon; Kumar, Ranganathan

2009-01-01

The effect of heat flux and pressure on bubble nucleation of R134a refrigerant in a flow boiling system is experimentally studied. An experimental facility was built and an innovative concept of thermochromic liquid crystal (TLC) technique was introduced for the high resolution and accurate measurement of the overall heater surface temperature. The visualization and image recording process is performed by employing two synchronized high resolution and high speed cameras which simultaneously capture colored TLC images as well as bubble nucleation activities at high frame rates. Experiments were conducted at different high pressures ranging from 690 to 830 kPa and at different heat flux conditions in order to identify their influence on flow boiling performance specially bubbling event. Present results demonstrate that both the heat flux and pressure influence the bubble generation rate and size. For example, bubble generation frequency and size are found to increase with heat flux. An increase in pressure of 137 kPa (from 690 to 827 kPa) increased the bubble frequency and size about 32 Hz and 20 μm, respectively. (author)

Bubbles & Squat

DEFF Research Database (Denmark)

Højbjerre Larsen, Signe

, a new concept called ‘Bubbles & Squat’, where fitness training is combined with Champagne and a live DJ. One of the invitations for this event describes how “we spice up your friday training with live DJ and lots of refreshing bubbles, to make sure that you are ready for the weekend (...).” Before New...

Development of an optical microscopy system for automated bubble cloud analysis.

Science.gov (United States)

Wesley, Daniel J; Brittle, Stuart A; Toolan, Daniel T W

2016-08-01

Recently, the number of uses of bubbles has begun to increase dramatically, with medicine, biofuel production, and wastewater treatment just some of the industries taking advantage of bubble properties, such as high mass transfer. As a result, more and more focus is being placed on the understanding and control of bubble formation processes and there are currently numerous techniques utilized to facilitate this understanding. Acoustic bubble sizing (ABS) and laser scattering techniques are able to provide information regarding bubble size and size distribution with minimal data processing, a major advantage over current optical-based direct imaging approaches. This paper demonstrates how direct bubble-imaging methods can be improved upon to yield high levels of automation and thus data comparable to ABS and laser scattering. We also discuss the added benefits of the direct imaging approaches and how it is possible to obtain considerable additional information above and beyond that which ABS and laser scattering can supply. This work could easily be exploited by both industrial-scale operations and small-scale laboratory studies, as this straightforward and cost-effective approach is highly transferrable and intuitive to use.

Fluid dynamics of bubbly flows

International Nuclear Information System (INIS)

Ziegenhein, Thomas

2016-01-01

Bubbly flows can be found in many applications in chemical, biological and power engineering. Reliable simulation tools of such flows that allow the design of new processes and optimization of existing one are therefore highly desirable. CFD-simulations applying the multi-fluid approach are very promising to provide such a design tool for complete facilities. In the multi-fluid approach, however, closure models have to be formulated to model the interaction between the continuous and dispersed phase. Due to the complex nature of bubbly flows, different phenomena have to be taken into account and for every phenomenon different closure models exist. Therefore, reliable predictions of unknown bubbly flows are not yet possible with the multi-fluid approach. A strategy to overcome this problem is to define a baseline model in which the closure models including the model constants are fixed so that the limitations of the modeling can be evaluated by validating it on different experiments. Afterwards, the shortcomings are identified so that the baseline model can be stepwise improved without losing the validity for the already validated cases. This development of a baseline model is done in the present work by validating the baseline model developed at the Helmholtz-Zentrum Dresden-Rossendorf mainly basing on experimental data for bubbly pipe flows to bubble columns, bubble plumes and air-lift reactors that are relevant in chemical and biological engineering applications. In the present work, a large variety of such setups is used for validation. The buoyancy driven bubbly flows showed thereby a transient behavior on the scale of the facility. Since such large scales are characterized by the geometry of the facility, turbulence models cannot describe them. Therefore, the transient simulation of bubbly flows with two equation models based on the unsteady Reynolds-averaged Navier-Stokes equations is investigated. In combination with the before mentioned baseline model these

Fluid dynamics of bubbly flows

Energy Technology Data Exchange (ETDEWEB)

Ziegenhein, Thomas

2016-07-08

Bubbly flows can be found in many applications in chemical, biological and power engineering. Reliable simulation tools of such flows that allow the design of new processes and optimization of existing one are therefore highly desirable. CFD-simulations applying the multi-fluid approach are very promising to provide such a design tool for complete facilities. In the multi-fluid approach, however, closure models have to be formulated to model the interaction between the continuous and dispersed phase. Due to the complex nature of bubbly flows, different phenomena have to be taken into account and for every phenomenon different closure models exist. Therefore, reliable predictions of unknown bubbly flows are not yet possible with the multi-fluid approach. A strategy to overcome this problem is to define a baseline model in which the closure models including the model constants are fixed so that the limitations of the modeling can be evaluated by validating it on different experiments. Afterwards, the shortcomings are identified so that the baseline model can be stepwise improved without losing the validity for the already validated cases. This development of a baseline model is done in the present work by validating the baseline model developed at the Helmholtz-Zentrum Dresden-Rossendorf mainly basing on experimental data for bubbly pipe flows to bubble columns, bubble plumes and air-lift reactors that are relevant in chemical and biological engineering applications. In the present work, a large variety of such setups is used for validation. The buoyancy driven bubbly flows showed thereby a transient behavior on the scale of the facility. Since such large scales are characterized by the geometry of the facility, turbulence models cannot describe them. Therefore, the transient simulation of bubbly flows with two equation models based on the unsteady Reynolds-averaged Navier-Stokes equations is investigated. In combination with the before mentioned baseline model these

Dependence of bubble behavior in subcooled boiling on surface wettability

International Nuclear Information System (INIS)

Harada, Takahiro; Nagakura, Hiroshi; Okawa, Tomio

2010-01-01

This paper presents the results of visualization experiments that were carried out to investigate the dynamics of vapor bubbles generated in water pool boiling. In the experiments, vapor bubbles were generated on a vertical circular surface of a copper block containing nine cartridge heaters, and the contact angle of the heated surface was used as a main experimental parameter. The experiments were performed under subcooled as well as nearly saturated conditions. To enable clear observation of individual bubbles with a high speed camera, the heat flux was kept low enough to eliminate significant overlapping of bubbles. When the contact angle was small, the bubbles were lifted-off the vertical heated surface within a short period of time after the nucleation. On the other hand, when the contact angle was large, they slid up the vertical surface for a long distance. When bubbles were lifted-off the heated surface in subcooled liquid, bubble life-time was significantly shortened since bubbles collapsed rapidly due to condensation. It was shown that this distinct difference in bubble dynamics could be attributed to the effects of surface tension force.

Critical scattering by bubbles

International Nuclear Information System (INIS)

Fiedler-Ferrari, N.; Nussenzveig, H.M.

1986-11-01

We apply the complex angular momentum theory to the problem of the critical scattering of light by spherical cavities in the high frequency limit (permittivity greater than the external media) (e.g, air bubble in water) (M.W.O.) [pt

Microscopic bubble behaviour in suppression pool during wetwell venting

Science.gov (United States)

Zablackaite, G.; Nagasaka, H.; Kikura, H.

2017-10-01

During a severe accident PCV failure should be avoided and fission products inside PCV should be confined as much as possible. In order to minimize FPs release, Wetwell venting is conducted by releasing steam-non-condensable gas mixture carrying FPs from the Drywell to Suppression Pool. Steam is condensed by subcooled water in the pool, and most of FPs are retained into water. The removal of FP in the water pool is referred to as “Pool Scrubbing effect”. Hydrodynamic parameters of bubbles have impact on pool scrubbing effect. However, there is only few data available to evaluate quantitatively the bubble behaviour under depressurization and/or thermal stratification conditions. Series of experiments were conducted to evaluate the influence of temperature distribution, non-condensable gas content and pressure in the Wetwell on bubble behaviour. Bubbles were visualized using High Speed Camera and adopting shadowgraphy technique. Applying Particle Tracking Velocimetry, bubble velocity and size distribution were obtained from recorded images. Experimental results show that with increasing suppression pool temperature, bubbles reaching the pool surface decreased in size and traveling velocity became slower. In pressurized wetwell, bubble behaviour was similar to that in the heated up suppression pool case, although bubble parameters were similar to the low temperature case. Higher air content induced water surface movement and bubbles were smaller due to break up.

Sound propagation in water containing large tethered spherical encapsulated gas bubbles with resonance frequencies in the 50 Hz to 100 Hz range.

Science.gov (United States)

Lee, Kevin M; Hinojosa, Kevin T; Wochner, Mark S; Argo, Theodore F; Wilson, Preston S; Mercier, Richard S

2011-11-01

The efficacy of large tethered encapsulated gas bubbles for the mitigation of low frequency underwater noise was investigated with an acoustic resonator technique. Tethered latex balloons were used as the bubbles, which had radii of approximately 5 cm. Phase speeds were inferred from the resonances of a water and balloon-filled waveguide approximately 1.8 m in length. The Commander and Prosperetti effective-medium model [J. Acoust. Soc. Am. 85, 732-746 (1989)] quantitatively described the observed dispersion from well below to just below the individual bubble resonance frequency, and it qualitatively predicted the frequency range of high attenuation for void fractions between 2% and 5% for collections of stationary balloons within the waveguide. A finite-element model was used to investigate the sensitivity of the waveguide resonance frequencies, and hence the inferred phase speeds, to changes in individual bubble size and position. The results indicate that large tethered encapsulated bubbles could be used mitigate low frequency underwater noise and that the Commander and Prosperetti model would be useful in the design of such a system.

Dark Matter Limits From a 2L C3F8 Filled Bubble Chamber

Energy Technology Data Exchange (ETDEWEB)

Robinson, Alan Edward [Univ. of Chicago, IL (United States)

2015-12-01

The PICO-2L C3F8 bubble chamber search forWeakly Interacting Massive Particle (WIMP) dark matter was operated in the SNOLAB underground laboratory at the same location as the previous CF3I lled COUPP-4kg detector. Neutron calibrations using photoneutron sources in C3F8 and CF3I lled calibration bubble chambers were performed to verify the sensitivity of these target uids to dark matter scattering. This data was combined with similar measurements using a low-energy neutron beam at the University of Montreal and in situ calibrations of the PICO-2L and COUPP-4kg detectors. C3F8 provides much greater sensitivity to WIMP-proton scattering than CF3I in bubble chamber detectors. PICO-2L searched for dark matter recoils with energy thresholds below 10 keV. Radiopurity assays of detector materials were performed and the expected neutron recoil background was evaluated to be 1.6+0:3

Linear oscillation of gas bubbles in a viscoelastic material under ultrasound irradiation

Energy Technology Data Exchange (ETDEWEB)

Hamaguchi, Fumiya; Ando, Keita, E-mail: kando@mech.keio.ac.jp [Department of Mechanical Engineering, Keio University, Yokohama 223-8522 (Japan)

2015-11-15

Acoustically forced oscillation of spherical gas bubbles in a viscoelastic material is studied through comparisons between experiments and linear theory. An experimental setup has been designed to visualize bubble dynamics in gelatin gels using a high-speed camera. A spherical gas bubble is created by focusing an infrared laser pulse into (gas-supersaturated) gelatin gels. The bubble radius (up to 150 μm) under mechanical equilibrium is controlled by gradual mass transfer of gases across the bubble interface. The linearized bubble dynamics are studied from the observation of spherical bubble oscillation driven by low-intensity, planar ultrasound driven at 28 kHz. It follows from the experiment for an isolated bubble that the frequency response in its volumetric oscillation was shifted to the high frequency side and its peak was suppressed as the gelatin concentration increases. The measurement is fitted to the linearized Rayleigh–Plesset equation coupled with the Voigt constitutive equation that models the behavior of linear viscoelastic solids; the fitting yields good agreement by tuning unknown values of the viscosity and rigidity, indicating that more complex phenomena including shear thinning, stress relaxation, and retardation do not play an important role for the small-amplitude oscillations. Moreover, the cases for bubble-bubble and bubble-wall systems are studied. The observed interaction effect on the linearized dynamics can be explained as well by a set of the Rayleigh–Plesset equations coupled through acoustic radiation among these systems. This suggests that this experimental setup can be applied to validate the model of bubble dynamics with more complex configuration such as a cloud of bubbles in viscoelastic materials.

Bubble departure diameter in narrow rectangular channel under rolling condition

Energy Technology Data Exchange (ETDEWEB)

Xie, T.; Chen, B.; Yan, X.; Xu, J.; Huang, Y.; Xiao, Z. [Nuclear Power Inst. of China, Chengdu, Sichuan (China)

2014-07-01

Forced convective subcooled boiling flow experiments were conducted in a vertical upward narrow rectangular channel under rolling motion. A high-speed digital video camera was used to capture the dynamics of the bubble nucleation process. Bubble departure diameters were obtained from the images. A bubble departure model based on force balance analysis was proposed to predict the bubble departure size under rolling condition by considering the additional centrifugal, tangential and Coriolis force. The proposed model agreed well with the experimental data within the averaged relative deviation of 5%. (author)

A modified captive bubble method for determining advancing and receding contact angles

International Nuclear Information System (INIS)

Xue, Jian; Shi, Pan; Zhu, Lin; Ding, Jianfu; Chen, Qingmin; Wang, Qingjun

2014-01-01

Graphical abstract: - Highlights: • A modified captive bubble method for determining advancing and receding contact angle is proposed. • We have designed a pressure chamber with a pressure control system to the original experimental. • The modified method overcomes the deviation of the bubble in the traditional captive bubble method. • The modified captive bubble method allows a smaller error from the test. - Abstract: In this work, a modification to the captive bubble method was proposed to test the advancing and receding contact angle. This modification is done by adding a pressure chamber with a pressure control system to the original experimental system equipped with an optical angle mater equipped with a high speed CCD camera, a temperature control system and a computer. A series of samples with highly hydrophilic, hydrophilic, hydrophobic and superhydrophobic surfaces were prepared. The advancing and receding contact angles of these samples with highly hydrophilic, hydrophilic, and hydrophobic surfaces through the new methods was comparable to the result tested by the traditional sessile drop method. It is proved that this method overcomes the limitation of the traditional captive bubble method and the modified captive bubble method allows a smaller error from the test. However, due to the nature of the captive bubble technique, this method is also only suitable for testing the surface with advancing or receding contact angle below 130°

A modified captive bubble method for determining advancing and receding contact angles

Energy Technology Data Exchange (ETDEWEB)

Xue, Jian; Shi, Pan; Zhu, Lin [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China); Ding, Jianfu [Security and Disruptive Technologies, National Research Council Canada, 1200 Montreal Road, Ottawa, K1A 0R6, Ontario (Canada); Chen, Qingmin [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China); Wang, Qingjun, E-mail: njuwqj@nju.edu.cn [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China)

2014-03-01

Graphical abstract: - Highlights: • A modified captive bubble method for determining advancing and receding contact angle is proposed. • We have designed a pressure chamber with a pressure control system to the original experimental. • The modified method overcomes the deviation of the bubble in the traditional captive bubble method. • The modified captive bubble method allows a smaller error from the test. - Abstract: In this work, a modification to the captive bubble method was proposed to test the advancing and receding contact angle. This modification is done by adding a pressure chamber with a pressure control system to the original experimental system equipped with an optical angle mater equipped with a high speed CCD camera, a temperature control system and a computer. A series of samples with highly hydrophilic, hydrophilic, hydrophobic and superhydrophobic surfaces were prepared. The advancing and receding contact angles of these samples with highly hydrophilic, hydrophilic, and hydrophobic surfaces through the new methods was comparable to the result tested by the traditional sessile drop method. It is proved that this method overcomes the limitation of the traditional captive bubble method and the modified captive bubble method allows a smaller error from the test. However, due to the nature of the captive bubble technique, this method is also only suitable for testing the surface with advancing or receding contact angle below 130°.

Robustness Property of Robust-BD Wald-Type Test for Varying-Dimensional General Linear Models

Directory of Open Access Journals (Sweden)

Xiao Guo

2018-03-01

Full Text Available An important issue for robust inference is to examine the stability of the asymptotic level and power of the test statistic in the presence of contaminated data. Most existing results are derived in finite-dimensional settings with some particular choices of loss functions. This paper re-examines this issue by allowing for a diverging number of parameters combined with a broader array of robust error measures, called “robust- BD ”, for the class of “general linear models”. Under regularity conditions, we derive the influence function of the robust- BD parameter estimator and demonstrate that the robust- BD Wald-type test enjoys the robustness of validity and efficiency asymptotically. Specifically, the asymptotic level of the test is stable under a small amount of contamination of the null hypothesis, whereas the asymptotic power is large enough under a contaminated distribution in a neighborhood of the contiguous alternatives, thus lending supports to the utility of the proposed robust- BD Wald-type test.

Influence of cavitation bubble growth by rectified diffusion on cavitation-enhanced HIFU

Science.gov (United States)

Okita, Kohei; Sugiyama, Kazuyasu; Takagi, Shu; Matsumoto, Yoichiro

2017-11-01

Cavitation is becoming increasingly important in therapeutic ultrasound applications such as diagnostic, tumor ablation and lithotripsy. Mass transfer through gas-liquid interface due to rectified diffusion is important role in an initial stage of cavitation bubble growth. In the present study, influences of the rectified diffusion on cavitation-enhanced high-intensity focused ultrasound (HIFU) was investigated numerically. Firstly, the mass transfer rate of gas from the surrounding medium to the bubble was examined as function of the initial bubble radius and the driving pressure amplitude. As the result, the pressure required to bubble growth was decreases with increasing the initial bubble radius. Next, the cavitation-enhanced HIFU, which generates cavitation bubbles by high-intensity burst and induces the localized heating owing to cavitation bubble oscillation by low-intensity continuous waves, was reproduced by the present simulation. The heating region obtained by the simulation is agree to the treatment region of an in vitro experiment. Additionally, the simulation result shows that the localized heating is enhanced by the increase of the equilibrium bubble size due to the rectified diffusion. This work was supported by JSPS KAKENHI Grant Numbers JP26420125,JP17K06170.

Bubble transport in bifurcations

Science.gov (United States)

Bull, Joseph; Qamar, Adnan

2017-11-01

Motivated by a developmental gas embolotherapy technique for cancer treatment, we examine the transport of bubbles entrained in liquid. In gas embolotherapy, infarction of tumors is induced by selectively formed vascular gas bubbles that originate from acoustic vaporization of vascular droplets. In the case of non-functionalized droplets with the objective of vessel occlusion, the bubbles are transported by flow through vessel bifurcations, where they may split prior to eventually reach vessels small enough that they become lodged. This splitting behavior affects the distribution of bubbles and the efficacy of flow occlusion and the treatment. In these studies, we investigated bubble transport in bifurcations using computational and theoretical modeling. The model reproduces the variety of experimentally observed splitting behaviors. Splitting homogeneity and maximum shear stress along the vessel walls is predicted over a variety of physical parameters. Maximum shear stresses were found to decrease with increasing Reynolds number. The initial bubble length was found to affect the splitting behavior in the presence of gravitational asymmetry. This work was supported by NIH Grant R01EB006476.

Dark matter limits froma 15 kg windowless bubble chamber

Energy Technology Data Exchange (ETDEWEB)

Szydagis, Matthew Mark [Univ. of Chicago, IL (United States)

2011-03-01

The COUPP collaboration has successfully used bubble chambers, a technology previously applied only to high-energy physics experiments, as direct dark matter detectors. It has produced the world's most stringent spin-dependent WIMP limits, and increasingly competitive spin-independent limits. These limits were achieved by capitalizing on an intrinsic rejection of the gamma background that all other direct detection experiments must address through high-density shielding and empirically-determined data cuts. The history of COUPP, including its earliest prototypes and latest results, is briefly discussed in this thesis. The feasibility of a new, windowless bubble chamber concept simpler and more inexpensive in design is discussed here as well. The dark matter limits achieved with a 15 kg windowless chamber, larger than any previous COUPP chamber (2 kg, 4 kg), are presented. Evidence of the greater radiopurity of synthetic quartz compared to natural is presented using the data from this 15 kg device, the first chamber to be made from synthetic quartz. The effective reconstruction of the three-dimensional positions of bubbles in a highly distorted optical field, with ninety-degree bottom lighting similar to cloud chamber lighting, is demonstrated. Another innovation described in this thesis is the use of the sound produced by bubbles recorded by an array of piezoelectric sensors as the primary means of bubble detection. In other COUPP chambers, cameras have been used as the primary trigger. Previous work on bubble acoustic signature differentiation using piezos is built upon in order to further demonstrate the ability to discriminate between alpha- and neutron-induced events.

Bubble growth in a narrow horizontal space

International Nuclear Information System (INIS)

Stutz, Benoit; Goulet, Remi; Passos, Julio Cesar

2009-01-01

The purpose of this work is to develop an axis-symmetric two-phase flow model describing the growth of a single bubble squeezed between a horizontal heated upward-facing disc and an insulating surface placed parallel to the heated surface. Heat transfers at the liquid-vapour interfaces are predicted by the kinetic limit of vaporisation. The depths of the liquid films deposed on the surfaces (heated surface and confinement space) are determined using the Moriyama and Inoue correlation (1996). Transient heat transfers within the heated wall are taken into account. The model is applied to pentane bubble growth. The influence of the gap size, the initial temperature of the system, the thermal effusivity of the heated wall and the kinetic limit of vaporisation are studied. The results show that the expansion of the bubbles strongly depends on the gap size and can be affected by the effusivity of the material. Mechanical inertia effects are mainly dominant at the beginning of the bubble expansion. Pressure drop induced by viscous effects have to be taken into account for high capillary numbers. Heat transfers at the meniscus are negligible except at the early stages of the bubble growth. (author)

Bubble growth in a narrow horizontal space

Energy Technology Data Exchange (ETDEWEB)

Stutz, Benoit; Goulet, Remi [CETHIL, UMR5008, CNRS, INSA-Lyon, Universite Lyon1 (France); Passos, Julio Cesar [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Dept. de Engenharia Mecanica. LABSOLAR

2009-07-01

The purpose of this work is to develop an axis-symmetric two-phase flow model describing the growth of a single bubble squeezed between a horizontal heated upward-facing disc and an insulating surface placed parallel to the heated surface. Heat transfers at the liquid-vapour interfaces are predicted by the kinetic limit of vaporisation. The depths of the liquid films deposed on the surfaces (heated surface and confinement space) are determined using the Moriyama and Inoue correlation (1996). Transient heat transfers within the heated wall are taken into account. The model is applied to pentane bubble growth. The influence of the gap size, the initial temperature of the system, the thermal effusivity of the heated wall and the kinetic limit of vaporisation are studied. The results show that the expansion of the bubbles strongly depends on the gap size and can be affected by the effusivity of the material. Mechanical inertia effects are mainly dominant at the beginning of the bubble expansion. Pressure drop induced by viscous effects have to be taken into account for high capillary numbers. Heat transfers at the meniscus are negligible except at the early stages of the bubble growth. (author)

Experimental investigation of shock wave - bubble interaction

Energy Technology Data Exchange (ETDEWEB)

Alizadeh, Mohsen

2010-04-09

In this work, the dynamics of laser-generated single cavitation bubbles exposed to lithotripter shock waves has been investigated experimentally. The energy of the impinging shock wave is varied in several steps. High-speed photography and pressure field measurements simultaneously with image acquisition provide the possibility of capturing the fast bubble dynamics under the effect of the shock wave impact. The pressure measurement is performed using a fiber optic probe hydrophone (FOPH) which operates based on optical diagnostics of the shock wave propagating medium. After a short introduction in chapter 1 an overview of the previous studies in chapter 2 is presented. The reported literatures include theoretical and experimental investigations of several configurations of physical problems in the field of bubble dynamics. In chapter 3 a theoretical description of propagation of a shock wave in a liquid like water has been discussed. Different kinds of reflection of a shock wave at an interface are taken into account. Undisturbed bubble dynamics as well as interaction between a planar shock wave and an initially spherical bubble are explored theoretically. Some physical parameters which are important in this issue such as the velocity of the shock-induced liquid jet, Kelvin impulse and kinetic energy are explained. The shock waves are generated in a water filled container by a focusing piezoelectric generator. The shock wave profile has a positive part with pulse duration of ∼1 μs followed by a longer tension tail (i.e. ∼3 μs). In chapter 4 high-speed images depict the propagation of a shock wave in the water filled tank. The maximum pressure is also derived for different intensity levels of the shock wave generator. The measurement is performed in the free field (i.e. in the absence of laser-generated single bubbles). In chapter 5 the interaction between lithotripter shock waves and laserinduced single cavitation bubbles is investigated experimentally. An

Bubble Dynamics and Shock Waves

CERN Document Server

2013-01-01

This volume of the Shock Wave Science and Technology Reference Library is concerned with the interplay between bubble dynamics and shock waves. It is divided into four parts containing twelve chapters written by eminent scientists. Topics discussed include shock wave emission by laser generated bubbles (W Lauterborn, A Vogel), pulsating bubbles near boundaries (DM Leppinen, QX Wang, JR Blake), interaction of shock waves with bubble clouds (CD Ohl, SW Ohl), shock propagation in polydispersed bubbly liquids by model equations (K Ando, T Colonius, CE Brennen. T Yano, T Kanagawa,  M Watanabe, S Fujikawa) and by DNS (G Tryggvason, S Dabiri), shocks in cavitating flows (NA Adams, SJ Schmidt, CF Delale, GH Schnerr, S Pasinlioglu) together with applications involving encapsulated bubble dynamics in imaging (AA Doinikov, A Novell, JM Escoffre, A Bouakaz),  shock wave lithotripsy (P Zhong), sterilization of ships’ ballast water (A Abe, H Mimura) and bubbly flow model of volcano eruptions ((VK Kedrinskii, K Takayama...

Bubble Coalescence: Effect of Bubble Approach Velocity and Liquid Viscosity

Czech Academy of Sciences Publication Activity Database

Orvalho, Sandra; Růžička, Marek; Olivieri, G.; Marzocchella, A.

2015-01-01

Roč. 134, SEP 29 (2015), s. 205-216 ISSN 0009-2509 R&D Projects: GA MŠk(CZ) LD13018 Institutional support: RVO:67985858 Keywords : bubble coalescence * bubble approach velocity * liquid viscosity Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.750, year: 2015

Ignition modes of nanosecond discharge with bubbles in distilled water

International Nuclear Information System (INIS)

Hamdan, Ahmad; Cha, Min Suk

2015-01-01

Here, we present the microscopic physical characteristics of nanosecond discharges with an array of bubbles in distilled water. In particular, applying a single high-voltage pulse, four delayed intensified charge-coupled device cameras successfully visualized four successive images during a single discharge event. We identified three distinctive modes of ignition inside a bubble, depending on the relative location of the bubble with respect to pin-to-hollow needle electrodes when a single bubble was located in an inter-electrode gap of 1 mm: anode-driven ignition, cathode-driven ignition, and co-ignition near both electrodes. Anode- and cathode-driven ignitions evolved into either a complete propagation of the streamer or an incomplete propagation, which were limited in location by proximity to an ignition location, while co-ignitions consistently showed complete propagation. When we increased the gap to 2 mm to accommodate multiple bubbles in the gap, an ignited bubble near the cathode was able to cause the ignition of an upper adjacent bubble. Bubble–bubble interface zones can also be spots of ignition, such that we observed simultaneous co-ignitions in the zones of bubble–bubble interfaces and near electrodes with triple bubbles. We compared the experimental results of discharge propagation with different ignition modes between Ar, He, and N 2 bubbles. In addition, numerical simulations for static electric fields reasonably supported observed ignition behavior such that field intensity was locally enhanced. (paper)

Bubble propagation on a rail: a concept for sorting bubbles by size

Science.gov (United States)

Franco-Gómez, Andrés; Thompson, Alice B.; Hazel, Andrew L.; Juel, Anne

We demonstrate experimentally that the introduction of a rail, a small height constriction, within the cross-section of a rectangular channel could be used as a robust passive sorting device in two-phase fluid flows. Single air bubbles carried within silicone oil are generally transported on one side of the rail. However, for flow rates marginally larger than a critical value, a narrow band of bubble sizes can propagate (stably) over the rail, while bubbles of other sizes segregate to the side of the rail. The width of this band of bubble sizes increases with flow rate and the size of the most stable bubble can be tuned by varying the rail width. We present a complementary theoretical analysis based on a depth-averaged theory, which is in qualitative agreement with the experiments. The theoretical study reveals that the mechanism relies on a non-trivial interaction between capillary and viscous forces that is fully dynamic, rather than being a simple modification of capillary static solutions.

Single-bubble dynamics in pool boiling of one-component fluids

KAUST Repository

Xu, Xinpeng; Qian, Tiezheng

2014-01-01

We numerically investigate the pool boiling of one-component fluids with a focus on the effects of surface wettability on the single-bubble dynamics. We employed the dynamic van der Waals theory [Phys. Rev. E 75, 036304 (2007)], a diffuse-interface model for liquid-vapor flows involving liquid-vapor transition in nonuniform temperature fields. We first perform simulations for bubbles on homogeneous surfaces. We find that an increase in either the contact angle or the surface superheating can enhance the bubble spreading over the heating surface and increase the bubble departure diameter as well and therefore facilitate the transition into film boiling. We then examine the dynamics of bubbles on patterned surfaces, which incorporate the advantages of both hydrophobic and hydrophilic surfaces. The central hydrophobic region increases the thermodynamic probability of bubble nucleation while the surrounding hydrophilic region hinders the continuous bubble spreading by pinning the contact line at the hydrophobic-hydrophilic intersection. This leads to a small bubble departure diameter and therefore prevents the transition from nucleate boiling into film boiling. With the bubble nucleation probability increased and the bubble departure facilitated, the efficiency of heat transfer on such patterned surfaces is highly enhanced, as observed experimentally [Int. J. Heat Mass Transfer 57, 733 (2013)]. In addition, the stick-slip motion of contact line on patterned surfaces is demonstrated in one-component fluids, with the effect weakened by surface superheating.

Single-bubble dynamics in pool boiling of one-component fluids

KAUST Repository

Xu, Xinpeng

2014-06-04

We numerically investigate the pool boiling of one-component fluids with a focus on the effects of surface wettability on the single-bubble dynamics. We employed the dynamic van der Waals theory [Phys. Rev. E 75, 036304 (2007)], a diffuse-interface model for liquid-vapor flows involving liquid-vapor transition in nonuniform temperature fields. We first perform simulations for bubbles on homogeneous surfaces. We find that an increase in either the contact angle or the surface superheating can enhance the bubble spreading over the heating surface and increase the bubble departure diameter as well and therefore facilitate the transition into film boiling. We then examine the dynamics of bubbles on patterned surfaces, which incorporate the advantages of both hydrophobic and hydrophilic surfaces. The central hydrophobic region increases the thermodynamic probability of bubble nucleation while the surrounding hydrophilic region hinders the continuous bubble spreading by pinning the contact line at the hydrophobic-hydrophilic intersection. This leads to a small bubble departure diameter and therefore prevents the transition from nucleate boiling into film boiling. With the bubble nucleation probability increased and the bubble departure facilitated, the efficiency of heat transfer on such patterned surfaces is highly enhanced, as observed experimentally [Int. J. Heat Mass Transfer 57, 733 (2013)]. In addition, the stick-slip motion of contact line on patterned surfaces is demonstrated in one-component fluids, with the effect weakened by surface superheating.

SIMMER analysis of SRI high pressure bubble expansion experiments

International Nuclear Information System (INIS)

Rexroth, P.E.; Suo-Anttila, A.J.

1979-01-01

SIMMER-II was used to analyze the results of the SRI nitrogen bubble expansion experiments. Good agreement was found for all of the experiments analyzed as well as the theoretical isentropic limiting case. Scaling to a full size CRBR reactor reveals no significant scaling effects for the structureless core

Bubble Formation in Basalt-like Melts

DEFF Research Database (Denmark)

Jensen, Martin; Keding, Ralf; Yue, Yuanzheng

2011-01-01

and their diameter. The variation in melting temperature has little influence on the overall bubble volume. However, the size distribution of the bubbles varies with the melting temperature. When the melt is slowly cooled, the bubble volume increases, implying decreased solubility of the gaseous species. Mass...... spectroscopy analysis of gases liberated during heating of the glass reveals that small bubbles contain predominantly CH4, CO and CO2, whereas large bubbles bear N2, SO2 and H2S. The methodology utilised in this work can, besides mapping the bubbles in a glass, be applied to shed light on the sources of bubble...

Photochemistry of U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/

Energy Technology Data Exchange (ETDEWEB)

Paine, R T; Schonberg, P R; Light, R W [New Mexico Univ., Albuquerque (USA). Dept. of Chemistry; Danen, W C; Freund, S M

1979-01-01

U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/ are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH/sub 4/)/sub 3/, B/sub 2/H/sub 6/, H/sub 2/, U(BD/sub 4/)/sub 3/, B/sub 2/D/sub 6/ and D/sub 2/. Further, U(BD/sub 4/)/sub 4/ undergoes a related decomposition reaction under the influence of CO/sub 2/ laser irradiation at 924.97 cm/sup -1/.

A description of bubble growth and gas release of helium implanted tungsten

International Nuclear Information System (INIS)

Sharafat, S.; Hu, Q.; Ghoniem, N.; Tkahashi, A.

2007-01-01

Full text of publication follows: Bubble growth and gas release during annealing of helium implanted tungsten is described using a Kinetic Monte Carlo approach. The implanted spatial profiles of stable bubble nuclei are first determined using the Kinetic Rate Theory based helium evolution code, HEROS. The effects of implantation energy, temperature, and bias forces, such as temperature- and stress gradients on bubble migration and coalescence are investigated to explain experimental gas release measurements. This comprehensive helium bubble evolution and release model, demonstrates the impact of near surface (< 1 um) versus deep helium implantation on bubble evolution. Near surface implanted helium bubbles readily attain large equilibrium sizes, while matrix bubbles remain small with high helium pressures. Using the computer simulation, the various stages of helium bubble nucleation, growth, coalescence, and migration are demonstrated and compared with available experimental results. (authors)

Micro-bubble morphologies following drop impacts onto a pool surface

KAUST Repository

Thoroddsen, Sigurdur T; Thoraval, M.-J.; Takehara, K.; Etoh, T.G.

2012-01-01

When a drop impacts at low velocity onto a pool surface, a hemispheric air layer cushions and can delay direct contact. Herein we use ultra-high-speed video to study the rupture of this layer, to explain the resulting variety of observed distribution of bubbles. The size and distribution of micro-bubbles is determined by the number and location of the primary punctures. Isolated holes lead to the formation of bubble necklaces when the edges of two growing holes meet, whereas bubble nets are produced by regular shedding of micro-bubbles from a sawtooth edge instability. For the most viscous liquids the air film contracts more rapidly than the capillary-viscous velocity through repeated spontaneous ruptures of the edge. From the speed of hole opening and the total volume of micro-bubbles we conclude that the air sheet ruptures when its thickness approaches ?100.

Micro-bubble morphologies following drop impacts onto a pool surface

KAUST Repository

Thoroddsen, Sigurdur T.

2012-10-01

When a drop impacts at low velocity onto a pool surface, a hemispheric air layer cushions and can delay direct contact. Herein we use ultra-high-speed video to study the rupture of this layer, to explain the resulting variety of observed distribution of bubbles. The size and distribution of micro-bubbles is determined by the number and location of the primary punctures. Isolated holes lead to the formation of bubble necklaces when the edges of two growing holes meet, whereas bubble nets are produced by regular shedding of micro-bubbles from a sawtooth edge instability. For the most viscous liquids the air film contracts more rapidly than the capillary-viscous velocity through repeated spontaneous ruptures of the edge. From the speed of hole opening and the total volume of micro-bubbles we conclude that the air sheet ruptures when its thickness approaches ?100.

A study of gas bubbles in liquid mercury in a vertical Hele-Shaw cell

Energy Technology Data Exchange (ETDEWEB)

Klaasen, B.; Blanpain, B. [KU Leuven, Research Group for High Temperature Processes and Industrial Ecology, Department of Metallurgy and Materials Engineering, Leuven (Belgium); Verhaeghe, F. [KU Leuven, Research Group for High Temperature Processes and Industrial Ecology, Department of Metallurgy and Materials Engineering, Leuven (Belgium); Umicore Group Research and Development, Olen (Belgium); Fransaer, J. [KU Leuven, Research Group for Materials with Novel Functionality, Department of Metallurgy and Materials Engineering, Leuven (Belgium)

2014-01-15

High-quality observations of mesoscopic gas bubbles in liquid metal are vital for a further development of pyrometallurgical gas injection reactors. However, the opacity of metals enforces the use of indirect imaging techniques with limited temporal or spatial resolution. In addition, accurate interface tracking requires tomography which further complicates the design of a high-temperature experimental setup. In this paper, an alternative approach is suggested that circumvents these two main restrictions. By injecting gas in a thin layer of liquid metal entrapped between two flat and closely spaced plates, bubbles in a Hele-Shaw flow regime are generated. The resulting quasi-2D multiphase flow phenomena can be fully captured from a single point of view and, when using a non-wetted transparent plate material, the bubbles can be observed directly. The feasibility of this approach is demonstrated by observations on buoyancy-driven nitrogen bubbles in liquid mercury in a vertical Hele-Shaw cell. By using a moving high-speed camera to make continuous close up recordings of individual bubbles, the position and geometry of these bubbles are quantified with a high resolution along their entire path. After a thorough evaluation of the experimental accuracy, this information is used for a detailed analysis of the bubble expansion along the path. While the observed bubble growth is mainly caused by the hydrostatic pressure gradient, a careful assessment of the volume variations for smaller bubbles shows that an accurate bubble description should account for significant dynamic pressure variations that seem to be largely regime dependent. (orig.)

An item response theory evaluation of the young mania rating scale and the montgomery-asberg depression rating scale in the systematic treatment enhancement program for bipolar disorder (STEP-BD).

Science.gov (United States)

Prisciandaro, James J; Tolliver, Bryan K

2016-11-15

The Young Mania Rating Scale (YMRS) and Montgomery-Asberg Depression Rating Scale (MADRS) are among the most widely used outcome measures for clinical trials of medications for Bipolar Disorder (BD). Nonetheless, very few studies have examined the measurement characteristics of the YMRS and MADRS in individuals with BD using modern psychometric methods. The present study evaluated the YMRS and MADRS in the Systematic Treatment Enhancement Program for BD (STEP-BD) study using Item Response Theory (IRT). Baseline data from 3716 STEP-BD participants were available for the present analysis. The Graded Response Model (GRM) was fit separately to YMRS and MADRS item responses. Differential item functioning (DIF) was examined by regressing a variety of clinically relevant covariates (e.g., sex, substance dependence) on all test items and on the latent symptom severity dimension, within each scale. Both scales: 1) contained several items that provided little or no psychometric information, 2) were inefficient, in that the majority of item response categories did not provide incremental psychometric information, 3) poorly measured participants outside of a narrow band of severity, 4) evidenced DIF for nearly all items, suggesting that item responses were, in part, determined by factors other than symptom severity. Limited to outpatients; DIF analysis only sensitive to certain forms of DIF. The present study provides evidence for significant measurement problems involving the YMRS and MADRS. More work is needed to refine these measures and/or develop suitable alternative measures of BD symptomatology for clinical trials research. Copyright © 2016 Elsevier B.V. All rights reserved.

Relative accuracy of the BD Logic and FreeStyle blood glucose meters.

Science.gov (United States)

2007-04-01

The BD Logic((R)) (Becton, Dickinson and Co., Franklin Lakes, NJ) and FreeStyle((R)) (Abbott Diabetes Care, Alameda, CA) meters are used to transmit data directly to insulin pumps for calculation of insulin doses and to calibrate continuous glucose sensors as well as to monitor blood glucose levels. The accuracy of the two meters was evaluated in two inpatient studies conducted by the Diabetes Research in Children Network (DirecNet). In both studies, meter glucose measurements made with either venous or capillary blood were compared with reference glucose measurements made by the DirecNet Central Laboratory at the University of Minnesota using a hexokinase enzymatic method. The BD Logic tended to read lower than the laboratory reference regardless of whether venous (median difference = -9 mg/dL) or capillary blood (median difference = -7 mg/dL) was used. This resulted in lower accuracy of the BD Logic compared with the FreeStyle meter based on the median relative absolute difference (RAD) for both venous blood (median RAD, 9% vs. 5%, P blood (median RAD, 11% vs. 6%, P = 0.008). The greatest discrepancy in the performance of the two meters was at higher reference glucose values. Accuracy was not significantly different when the reference was < or = 70 mg/dL. The BD Logic meter is less accurate than the FreeStyle meter.

Artificial neural network for bubbles pattern recognition on the images

International Nuclear Information System (INIS)

Poletaev, I E; Pervunin, K S; Tokarev, M P

2016-01-01

Two-phase bubble flows have been used in many technological and energy processes as processing oil, chemical and nuclear reactors. This explains large interest to experimental and numerical studies of such flows last several decades. Exploiting of optical diagnostics for analysis of the bubble flows allows researchers obtaining of instantaneous velocity fields and gaseous phase distribution with the high spatial resolution non-intrusively. Behavior of light rays exhibits an intricate manner when they cross interphase boundaries of gaseous bubbles hence the identification of the bubbles images is a complicated problem. This work presents a method of bubbles images identification based on a modern technology of deep learning called convolutional neural networks (CNN). Neural networks are able to determine overlapping, blurred, and non-spherical bubble images. They can increase accuracy of the bubble image recognition, reduce the number of outliers, lower data processing time, and significantly decrease the number of settings for the identification in comparison with standard recognition methods developed before. In addition, usage of GPUs speeds up the learning process of CNN owning to the modern adaptive subgradient optimization techniques. (paper)

Single bubble sonoluminescence

NARCIS (Netherlands)

Brenner, Michael P.; Hilgenfeldt, Sascha; Lohse, Detlef

2002-01-01

Single-bubble sonoluminescence occurs when an acoustically trapped and periodically driven gas bubble collapses so strongly that the energy focusing at collapse leads to light emission. Detailed experiments have demonstrated the unique properties of this system: the spectrum of the emitted light

Void fraction and velocity measurement of simulated bubble in a rotating disc using high frame rate neutron radiography.

Science.gov (United States)

Saito, Y; Mishima, K; Matsubayashi, M

2004-10-01

To evaluate measurement error of local void fraction and velocity field in a gas-molten metal two-phase flow by high-frame-rate neutron radiography, experiments using a rotating stainless-steel disc, which has several holes of various diameters and depths simulating gas bubbles, were performed. Measured instantaneous void fraction and velocity field of the simulated bubbles were compared with the calculated values based on the rotating speed, the diameter and the depth of the holes as parameters and the measurement error was evaluated. The rotating speed was varied from 0 to 350 rpm (tangential velocity of the simulated bubbles from 0 to 1.5 m/s). The effect of shutter speed of the imaging system on the measurement error was also investigated. It was revealed from the Lagrangian time-averaged void fraction profile that the measurement error of the instantaneous void fraction depends mainly on the light-decay characteristics of the fluorescent converter. The measurement error of the instantaneous local void fraction of simulated bubbles is estimated to be 20%. In the present imaging system, the light-decay characteristics of the fluorescent converter affect the measurement remarkably, and so should be taken into account in estimating the measurement error of the local void fraction profile.

Void fraction and velocity measurement of simulated bubble in a rotating disc using high frame rate neutron radiography

International Nuclear Information System (INIS)

Saito, Y.; Mishima, K.; Matsubayashi, M.

2004-01-01

To evaluate measurement error of local void fraction and velocity field in a gas-molten metal two-phase flow by high-frame-rate neutron radiography, experiments using a rotating stainless-steel disc, which has several holes of various diameters and depths simulating gas bubbles, were performed. Measured instantaneous void fraction and velocity field of the simulated bubbles were compared with the calculated values based on the rotating speed, the diameter and the depth of the holes as parameters and the measurement error was evaluated. The rotating speed was varied from 0 to 350 rpm (tangential velocity of the simulated bubbles from 0 to 1.5 m/s). The effect of shutter speed of the imaging system on the measurement error was also investigated. It was revealed from the Lagrangian time-averaged void fraction profile that the measurement error of the instantaneous void fraction depends mainly on the light-decay characteristics of the fluorescent converter. The measurement error of the instantaneous local void fraction of simulated bubbles is estimated to be 20%. In the present imaging system, the light-decay characteristics of the fluorescent converter affect the measurement remarkably, and so should be taken into account in estimating the measurement error of the local void fraction profile

Explosive micro-bubble actuator

NARCIS (Netherlands)

van den Broek, D.M.; Elwenspoek, Michael Curt

2007-01-01

Explosive evaporation occurs when a thin layer of liquid reaches a very high temperature in a very short time. At these temperatures homogeneous nucleation takes place. The nucleated bubbles almost instantly coalesce forming a vapour film followed by rapid growth due to the pressure impulse and

Bubble jet impact on a rigid wall of different stand-off parameters

International Nuclear Information System (INIS)

Li, S; Wang, S P; Zhang, A M

2015-01-01

One of the key features of the dynamics of a bubble near a rigid wall is the development of a high liquid jet, generating highly localized pressure on the wall. In present study, the boundary integral method is employed to simulate this phenomenon, and the vortex ring model is introduced to handle the discontinued potential of the toroidal bubble. Meanwhile, the pressure induced in the whole process is calculated by an auxiliary function. The effect of the stand-off parameter on the bubble dynamics and the pressure on the wall is investigated, and a double-peaked structure occurs in the pressure profile after the jet impact in some cases, which is associated with the jet impact and the high internal pressure inside the bubble

Turbulence modification in bubbly upward pipe flow. Extraction of time resolved turbulent microscopic structure by high speed PIV

International Nuclear Information System (INIS)

Yoshimura, Koki; Minato, Daiju; Sato, Yohei; Hishida, Koichi

2004-01-01

The objective of the present study is to obtain detailed information on the effects of bubbles on modification of turbulent structure by time-series measurements using a high speed time-resolved PIV. The experiments were carried out in a fully-developed vertical pipe with upflow of water at the Reynolds number of 9700 and the void fraction of 0.5%. It is observed that turbulence production was decreased and the dissipation rate was enhanced in the whole domain. We analyzed the effects of bubbles on modification of the energy cascade process from power spectra of velocity fluctuation of the continuous phase. (author)

Golden Jubilee photos - BEBC, the Big European Bubble Chamber

CERN Multimedia

2004-01-01

The vessel of the Big European Bubble Chamber, BEBC, was installed at the beginning of the 1970s. The large stainless-steel vessel, measuring 3.7 metres in diameter and 4 metres in height, was filled with 35 cubic metres of liquid (hydrogen, deuterium or a neon-hydrogen mixture), whose sensitivity was regulated by means of a huge piston weighing 2 tonnes. During each expansion, the trajectories of the charged particles were marked by a trail of bubbles, where liquid reached boiling point as they passed through it. The first images were recorded in 1973 when BEBC, equipped with the largest superconducting magnet in service at the time, first received beam from the PS. In 1977, the bubble chamber was exposed to neutrino and hadron beams at higher energies of up to 450 GeV after the SPS came into operation. By the end of its active life in 1984, BEBC had delivered a total of 6.3 million photographs to 22 experiments devoted to neutrino or hadron physics. Around 600 scient...

Droplets, Bubbles and Ultrasound Interactions.

Science.gov (United States)

Shpak, Oleksandr; Verweij, Martin; de Jong, Nico; Versluis, Michel

2016-01-01

The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.

Child toy safety: An interdisciplinary approach to unravel the microbiological hazard posed by soap bubbles.

Science.gov (United States)

Amoruso, Irene; Bertoncello, Chiara; Caravello, Gianumberto; Giaccone, Valerio; Baldovin, Tatjana

2015-11-01

In 2012 some children developed sepsis after playing together with a soap bubble toy. Microbiological testing revealed heavy contamination of the soap solution, which reasonably represented the vehicle of infection. We investigated the issue with a multidisciplinary approach: review of toy safety legislation; microbiological testing of additional samples; query of the RAPEX database for non-compliant soap bubbles; identification of major manufacturing districts. Microbiological contamination of industrial soap bubbles was widespread. Sixty-three notifications of batches contaminated by environmental microorganisms and opportunistic pathogens had been reported. The Chinese had a virtual monopoly of the soap bubble market. We identified two main manufacturing districts in Guangdong Province, both notable for degradation of their water resources. The use of untreated water for the industrial production of soap bubbles may explain the bacterial contamination. Existing legislation provides an unsatisfactory approach for managing microbiological hazards in sensitive toy categories and for identifying responsible parties in import and export of the products.

Detecting asymptomatic Trichomonas vaginalis in females using the BD ProbeTec™ Trichomonas vaginalis Qx nucleic acid amplification test.

Science.gov (United States)

Lord, Emily; Newnham, Tana; Dorrell, Lucy; Jesuthasan, Gerald; Clarke, Lorraine; Jeffery, Katie; Sherrard, Jackie

2017-03-01

Trichomonas vaginalis (TV) rates in women are increasing and many are asymptomatic. Nucleic acid amplification tests (NAATs) are becoming the 'gold standard' for diagnosis. We aimed to establish our asymptomatic TV rates by testing all women attending Oxfordshire's Sexual Health service, regardless of symptoms, using the BD ProbeTec™ TV Q x NAATs (BDQ x ). During BDQ x 's verification process, the sensitivity and specificity were calculated using results of 220 endocervical samples from symptomatic women, compared with culture. BDQ x was subsequently implemented and prospectively evaluated over 6 months in female attendees. Wet mount microscopy was also performed in symptomatics. Demographic and clinical characteristics of those diagnosed were analysed. From 220 samples tested by BDQ x and culture: 5 were positive on both and one solely using BDQ x , giving a sensitivity and specificity of 100% and 99.53%, respectively. In the prospective cohort, of 5775 BDQ x tests, 33 (0.57%) were positive. 11/33 (33%) patients were asymptomatic. All patients diagnosed had risk factors: age >25 years (85%), residence in a deprived area (79%) and black ethnicity (21%). Despite BDQ x being highly sensitive and specific, with our low TV prevalence universal screening may not be justified. Targeted screening using local demographic data merits further investigation.

The analysis of B-d ->(eta, eta ')l(+)l(-) decays in the standard model

NARCIS (Netherlands)

Erkol, G; Turan, G

We study the differential branching ratio, the branching ratio and the CP-violating asymmetry for the exclusive B-d --> (eta,eta')l(+)l(-) decays in the standard model. We deduce the B-d --> (eta,eta') form factors from the form factors of B --> pi available in the literature, by using the SU(3)(F)

Effect of hBD2 genetically modified dermal multipotent stem cells on repair of infected irradiated wounds

International Nuclear Information System (INIS)

Zong Zhaowen; Li Nan; Xiao Taoyuan

2010-01-01

Deficiencies in repair cells and infection are two of the main factors that can hinder the process of wound healing. In the present study, we investigated the ability of human beta-defensin-2 (hBD2) genetically modified dermal multipotent stem cells (dMSCs) to accelerate the healing irradiated wounds complicated by infections. An hBD2 adenovirus expression vector (Adv-hBD2) was firstly constructed and used to infect dMSCs. The antibacterial activity of the supernatant was determined by Kirby-Bauer method and macrodilution broth assay. Time to complete wound healing, residual percentage of wound area, and the number of bacteria under the scar were measured to assess the effects of Adv-hBD2-infected dMSC transplantation on the healing of irradiated wounds complicated by Pseudomonas aeruginosa infection. Results showed that the supernatant from Adv-hBD2-infected dMSCs had obvious antibacterial effects. Transplantation of Adv-hBD2-infected dMSCs killed bacteria in the wound. The complete wound healing time was 19.8±0.45 days, which was significantly shorter than in the control groups (P<0.05). From 14 days after transplantation, the residual wound area was smaller in the experimental group than in the control groups (P<0.05). In conculsion, we found that transplantation of hBD2 genetically modified dMSCs accelerated the healing of wounds complicated by P. aeruginosa infection in whole body irradiated rats. (author)

An equation of motion for bubble growth

International Nuclear Information System (INIS)

Lesage, F.J.; Cotton, J.S.; Robinson, A.J.

2009-01-01

A mathematical model is developed which describes asymmetric bubble growth, either during boiling or bubble injection from submerged orifices. The model is developed using the integral form of the continuity and momentum equations, resulting in a general expression for the acceleration of the bubble's centre of gravity. The proposed model highlights the need to include acceleration due to an asymmetric gain or loss of mass in order to accurately predict bubble motion. Some scenarios are posed by which the growth of bubbles, particularly idealized bubbles that remain a section of a sphere, must include the fact that bubble growth can be asymmetric. In particular, for approximately hemispherical bubble growth the sum of the forces acting on the bubble is negligible compared with the asymmetric term. Further, for bubble injection from a submerged needle this component in the equation of motion is very significant during the initial rapid growth phase as the bubble issues from the nozzle changing from a near hemisphere to truncated sphere geometry. (author)

Characteristics of a single bubble in subcooled boiling region of a narrow rectangular channel under natural circulation

International Nuclear Information System (INIS)

Zhou, Tao; Duan, Jun; Hong, Dexun; Liu, Ping; Sheng, Cheng; Huang, Yanping

2013-01-01

Highlights: ► We observe the behavior of single bubbles in a narrow vertical rectangular channel. ► We analyze the force characteristics of the single bubble. ► Small bubbles in highly subcooled boiling region stick on the wall or slip slowly. ► The bubbles jumping from the wall are affected by drag force. ► The thermophoretic force makes bubbles jump from the wall strongly. - Abstract: The behavior of bubbles has an important influence on heat transfer during subcooled boiling. By observing the behavior of a single bubble in a narrow vertical rectangular channel, and analyzing the force characteristics of the single bubble, it turns out that small bubbles in the highly subcooled boiling region stick on the wall or slip slowly. The bubbles jumping from the wall are affected by drag force, and move with high speed. Maintaining a certain heating power, at the onset of boiling (ONB) point, the bubbles remain in a stable state. Furthermore, the thermophoretic force is considered in this paper. With increasing the temperature gradient in the fluid, the thermophoretic force causes the bubbles to jump from the wall easier

Mixing and CP violation in the Bd and Bs systems at ATLAS

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00229256; The ATLAS collaboration

2016-01-01

This note includes a measurement of the $B^0_s$ decay parameters in the $ B_s \\rightarrow J/\\psi$ channel and a measurement of the $B_d$ meson using the statistics collected by the ATLAS experiment in Run I of the LHC. The first result presents the measurement of the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the width difference between the mass eigenstates $\\Delta \\Gamma_s$. The second result presents the measurement of the width difference $\\Delta \\Gamma_d$, which is extracted from the measurement of the lifetime dependence of $B_d \\to J/\\psi K_S$ and $B_d \\to J/\\psi K^{*0}$ decays. The obtained results are $\\phi_s = −0.098 \\pm 0.084 (\\textrm{stat.}) \\pm 0.040 (\\textrm{syst.})$ rad. and $\\Delta \\Gamma_d / \\Gamma_d = (-0.1 \\pm 1.1 (\\textrm{stat.}) \\pm 0.9 (\\textrm{syst.}))\\times 10^{-2}$.

Study of stream flow effects on bubble motion

International Nuclear Information System (INIS)

Sami, S.S.

1983-01-01

The formation of air bubbles at constant-pressure by submerged orifices was investigated in both quiescent and moving streams inside a vertical tube. Parameters affecting the bubble rise velocity, such as bubble generating frequency and diameter, were studied and analyzed for bubbles rising in a chain and homogeneous mixture. A special technique for measuring bubble motion parameters has been developed, tested, and employed throughout the experimental investigation. The method is based on a water-air impedance variation. Results obtained in stagnant liquid show that increasing the bubble diameter serves to increase bubble rise velocity, while an opposite trend has been observed for stream liquid where the bubble diameter increase reduces the bubble rise velocity. The increase of bubble generation frequency generally increases the bubble rise velocity. Experimental data covered with bubble radial distribution showed symmetrical profiles of bubble velocity and frequency, and the radial distribution of the velocity profiles sometimes has two maxima and one minimum depending on the liquid velocity. Finally, in stagnant liquid, a normalized correlation has been developed to predict the terminal rise velocity in terms of bubble generating frequency, bubble diameter, single bubble rise velocity, and conduit dimensions. Another correlation is presented for forced bubbly flow, where the bubble rise velocity is expressed as a function of bubble generating frequency, bubble diameter, and water superficial velocity

Degradation mechanisms of 4-chlorophenol in a novel gas-liquid hybrid discharge reactor by pulsed high voltage system with oxygen or nitrogen bubbling.

Science.gov (United States)

Zhang, Yi; Zhou, Minghua; Hao, Xiaolong; Lei, Lecheng

2007-03-01

The effect of gas bubbling on the removal efficiency of 4-chlorophenol (4-CP) in aqueous solution has been investigated using a novel pulsed high voltage gas-liquid hybrid discharge reactor, which generates gas-phase discharge above the water surface simultaneously with the spark discharge directly in the liquid. The time for 100% of 4-CP degradation in the case of oxygen bubbling (7 min) was much shorter than that in the case of nitrogen bubbling (25 min) as plenty of hydrogen peroxide and ozone formed in oxygen atmosphere enhanced the removal efficiency of 4-CP. Except for the main similar intermediates (4-chlorocatechol, hydroquinone and 1,4-benzoquinone) produced in the both cases of oxygen and nitrogen bubbling, special intermediates (5-chloro-3-nitropyrocatechol, 4-chloro-2-nitrophenol, nitrate and nitrite ions) were produced in nitrogen atmosphere. The reaction pathway of 4-CP in the case of oxygen bubbling was oxygen/ozone attack on the radical hydroxylated derivatives of 4-CP. However, in the case of nitrogen bubbling, hydroxylation was the main reaction pathway with effect of N atom on degradation of 4-CP.

The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance.

Directory of Open Access Journals (Sweden)

Julia Leclerc

Full Text Available Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance.

Experimental visualization coalesced interaction of sliding bubble near wall in vertical narrow rectangular channel

International Nuclear Information System (INIS)

Xu Jianjun; Chen Bingde; Wang Xiaojun

2011-01-01

The characteristic of the coalesced sliding bubble was visually observed by wide side and narrow side of the narrow rectangular channel using high speed digital camera. The results show that the coalesced time among the sliding bubbles is quick, and the new formation of coalesced bubble is not lift-off, and it continues to slide along the heated surface in low heat flux for the isolated bubble region. The influence region is about 2 times projected area of the sliding bubble when the sliding bubbles begin to interact. The sliding bubble velocities increase duo to the interaction among the bubbles, which contributes to enhance heat transfer of this region. Finally, the effect of coalesced interaction of growing bubble in the nucleation sites on bubble lift-off was discussed and analysed. (authors)

Bubbles in graphene

DEFF Research Database (Denmark)

Settnes, Mikkel; Power, Stephen; Lin, Jun

2015-01-01

Strain-induced deformations in graphene are predicted to give rise to large pseudomagnetic fields. We examine theoretically the case of gas-inflated bubbles to determine whether signatures of such fields are present in the local density of states. Sharp-edged bubbles are found to induce Friedel...

The gas bubbles distribution in 600 MeV protons irradiated aluminium

International Nuclear Information System (INIS)

Gavillet, D.; Martin, J.L.; Victoria, M.; Green, W.

1984-01-01

In order to simulate the damage produced by 14 MeV fusion neutrons, thin foils of high purity Al have been irradiated by a proton beam of 580 MeV (120μA). After irradiation at temperatures higher than 0.5 Tm transmission electron microscope observations of gas bubbles distribution were performed. At 200 0 C a uniform distribution of bubbles has been observed inside the grain. The average distance between bubbles and their density have been determined. The gas pressure inside the bubbles has been estimated [fr

Growth process of helium bubbles in aluminium

International Nuclear Information System (INIS)

Shiraishi, Haruki; Sakairi, Hideo; Yagi, Eiichi; Karasawa, Takashi; Hashiguti, R.R.

1975-01-01

The growth process of helium bubbles in α-particle bombarded pure aluminum during isothermal anneal ranging 200 to 645 0 C and 1 to 100 hr was observed by a transmission electron microscope and the possible growth mechanisms are discussed. The effects of helium concentration and cold work were investigated. The helium bubbles are detectable only at the anneal above 550 0 C in both annealed and cold worked samples. The cold work does not cause any extra coarsening trend of bubbles. The observed types of bubble distribution in the grain interior are divided into two categories, irrespective of helium concentration and cold work; (1) the fine and uniform bubble distribution, in which case the average size is limited to about 200 A or less in diameter even at the anneal just below the melting point, and (2) the coarsened and non-uniform bubble distribution ranging 500 to 4000 A in diameter. The intermediate size bubbles are scarcely found in any cases. In the above fine bubble distribution, the increase of helium concentration by a factor of two increases the density by the same factor of two, but does not change the mean size of bubbles. Corresponding to the above two characteristic bubble distributions, it is concluded that two different mechanisms are operative in this experiment; (1) the growth of bubbles by the Brownian motion, in which the growth rate of bubbles is decreased to almost zero by bubble faceting and this results in the bubble size constancy during the prolonged annealing, and (2) the growth of bubbles by the grain boundary sweep-out mechanism, by which the abrupt coarsening of bubbles is caused. The lack of existence of the intermediate size bubbles is explained in this way. (auth.)

Drop impact entrapment of bubble rings

KAUST Repository

Thoraval, M.-J.; Takehara, K.; Etoh, T.G.; Thoroddsen, Sigurdur T

2013-01-01

We use ultra-high-speed video imaging to look at the initial contact of a drop impacting on a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et

CHARACTERISTICS OF THE SECONDARY BUBBLE CLUSTER PRODUCED BY AN ELECTROHYDRAULIC SHOCK WAVE LITHOTRIPTER

Science.gov (United States)

Zhou, Yufeng; Qin, Jun; Zhong, Pei

2013-01-01

This study investigated the characteristics of the secondary bubble cluster produced by an electrohydraulic lithotripter using high-speed imaging and passive cavitation detection techniques. The results showed that (i) the discrepancy of the collapse time between near a flat rigid boundary and in a free field of the secondary bubble cluster was not as significant as that by the primary one; (ii) the secondary bubble clusters were small but in a high bubble density and nonuniform in distribution, and they did not expand and aggregate significantly near a rigid boundary; and (iii) the corresponding bubble collapse was weaker with few microjet formation and bubble rebound. By applying a strong suction flow near the electrode tip, the production of the secondary shock wave (SW) and induced bubble cluster could be disturbed significantly, but without influence on the primary ones. Consequently, stone fragmentation efficiency was reduced from 41.2 ± 7.1% to 32.2 ± 3.5% after 250 shocks (p <0.05). Altogether, these observations suggest that the secondary bubble cluster produced by an electrohydraulic lithotripter may contribute to its ability for effective stone fragmentation. PMID:22390990

Nuttier bubbles

International Nuclear Information System (INIS)

Astefanesei, Dumitru; Mann, Robert B.; Stelea, Cristian

2006-01-01

We construct new explicit solutions of general relativity from double analytic continuations of Taub-NUT spacetimes. This generalizes previous studies of 4-dimensional nutty bubbles. One 5-dimensional locally asymptotically AdS solution in particular has a special conformal boundary structure of AdS 3 x S 1 . We compute its boundary stress tensor and relate it to the properties of the dual field theory. Interestingly enough, we also find consistent 6-dimensional bubble solutions that have only one timelike direction. The existence of such spacetimes with non-trivial topology is closely related to the existence of the Taub-NUT(-AdS) solutions with more than one NUT charge. Finally, we begin an investigation of generating new solutions from Taub-NUT spacetimes and nuttier bubbles. Using the so-called Hopf duality, we provide new explicit time-dependent backgrounds in six dimensions

Sinking bubbles in stout beers

Science.gov (United States)

Lee, W. T.; Kaar, S.; O'Brien, S. B. G.

2018-04-01

A surprising phenomenon witnessed by many is the sinking bubbles seen in a settling pint of stout beer. Bubbles are less dense than the surrounding fluid so how does this happen? Previous work has shown that the explanation lies in a circulation of fluid promoted by the tilted sides of the glass. However, this work has relied heavily on computational fluid dynamics (CFD) simulations. Here, we show that the phenomenon of sinking bubbles can be predicted using a simple analytic model. To make the model analytically tractable, we work in the limit of small bubbles and consider a simplified geometry. The model confirms both the existence of sinking bubbles and the previously proposed mechanism.

Sensitivity studies on the multi-sensor conductivity probe measurement technique for two-phase flows

Energy Technology Data Exchange (ETDEWEB)

Worosz, Ted [Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, 230 Reber Building, University Park, PA 16802 (United States); Bernard, Matt [The United States Nuclear Regulatory Commission, 11545 Rockville Pike, Rockville, MD 20852 (United States); Kong, Ran; Toptan, Aysenur [Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, 230 Reber Building, University Park, PA 16802 (United States); Kim, Seungjin, E-mail: skim@psu.edu [Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, 230 Reber Building, University Park, PA 16802 (United States); Hoxie, Chris [The United States Nuclear Regulatory Commission, 11545 Rockville Pike, Rockville, MD 20852 (United States)

2016-12-15

Highlights: • Revised conductivity probe circuit to eliminate signal “ghosting” among sensors. • Higher sampling frequencies suggested for bubble number frequency and a{sub i} measurements. • Two-phase parameter sensitivity to measurement duration and bubble number investigated. • Sensors parallel to pipe wall recommended for symmetric bubble velocity measurements. • Sensor separation distance ratio (s/d) greater than four minimizes bubble velocity error. - Abstract: The objective of this study is to advance the local multi-sensor conductivity probe measurement technique through systematic investigation into several practical aspects of a conductivity probe measurement system. Firstly, signal “ghosting” among probe sensors is found to cause artificially high bubble velocity measurements and low interfacial area concentration (a{sub i}) measurements that depend on sampling frequency and sensor impedance. A revised electrical circuit is suggested to eliminate this artificial variability. Secondly, the sensitivity of the probe measurements to sampling frequency is investigated in 13 two-phase flow conditions with superficial liquid and gas velocities ranging from 1.00–5.00 m/s and 0.17–2.0 m/s, respectively. With increasing gas flow rate, higher sampling frequencies, greater than 100 kHz in some cases, are required to adequately capture the bubble number frequency and a{sub i} measurements. This trend is due to the increase in gas velocity and the transition to the slug flow regime. Thirdly, the sensitivity of the probe measurements to the measurement duration as well as the sample number is investigated for the same flow conditions. Measurements of both group-I (spherical/distorted) and group-II (cap/slug/churn-turbulent) bubbles are found to be relatively insensitive to both the measurement duration and the number of bubbles, as long as the measurements are made for a duration long enough to capture a collection of samples characteristic to a

Airway Mucosal Immune-suppression in Neonates of Mothers Receiving A(H1N1)pnd09 Vaccination During Pregnancy

DEFF Research Database (Denmark)

Pedersen, Susanne Brix; Bischoff, Anne L.; Folsgaard, Nilofar V.

2015-01-01

, IL-5, IL-13, eotaxin-1, eotaxin-3, TARC, MDC, IL-17, IL-1 beta, IL-8, transforming growth factor beta (TGF)-beta 1, IL-10 and IL-2. Infections were monitored the first year of life by daily diary cards and clinical controls. Results: Neonates of mothers vaccinated during pregnancy had significant up...... significant and positive association to up-regulation of TGF-beta 1 levels (P = 0.0003) and significant negative association to other mediators. The study was not powered to study differences in the incidence of infections in early infancy which did not differ between the study groups. Conclusion: Influenza A......(H1N1) pnd09 vaccination during pregnancy up-regulates TGF-beta 1 and down-regulates key mediators of the protective immunity....

Displacement of particles in microfluidics by laser-generated tandem bubbles

Science.gov (United States)

Lautz, Jaclyn; Sankin, Georgy; Yuan, Fang; Zhong, Pei

2010-11-01

The dynamic interaction between laser-generated tandem bubble and individual polystyrene particles of 2 and 10 μm in diameter is studied in a microfluidic channel (25 μm height) by high-speed imaging and particle image velocimetry. The asymmetric collapse of the tandem bubble produces a pair of microjets and associated long-lasting vortices that can propel a single particle to a maximum velocity of 1.4 m/s in 30 μs after the bubble collapse with a resultant directional displacement up to 60 μm in 150 μs. This method may be useful for high-throughput cell sorting in microfluidic devices.

Interaction mechanism of double bubbles in hydrodynamic cavitation

Science.gov (United States)

Li, Fengchao; Cai, Jun; Huai, Xiulan; Liu, Bin

2013-06-01

Bubble-bubble interaction is an important factor in cavitation bubble dynamics. In this paper, the dynamic behaviors of double cavitation bubbles driven by varying pressure field downstream of an orifice plate in hydrodynamic cavitation reactor are examined. The bubble-bubble interaction between two bubbles with different radii is considered. We have shown the different dynamic behaviors between double cavitation bubbles and a single bubble by solving two coupling nonlinear equations using the Runge-Kutta fourth order method with adaptive step size control. The simulation results indicate that, when considering the role of the neighbor smaller bubble, the oscillation of the bigger bubble gradually exhibits a lag in comparison with the single-bubble case, and the extent of the lag becomes much more obvious as time goes by. This phenomenon is more easily observed with the increase of the initial radius of the smaller bubble. In comparison with the single-bubble case, the oscillation of the bigger bubble is enhanced by the neighbor smaller bubble. Especially, the pressure pulse of the bigger bubble rises intensely when the sizes of two bubbles approach, and a series of peak values for different initial radii are acquired when the initial radius ratio of two bubbles is in the range of 0.9˜1.0. Although the increase of the center distance between two bubbles can weaken the mutual interaction, it has no significant influence on the enhancement trend. On the one hand, the interaction between two bubbles with different radii can suppress the growth of the smaller bubble; on the other hand, it also can enhance the growth of the bigger one at the same time. The significant enhancement effect due to the interaction of multi-bubbles should be paid more attention because it can be used to reinforce the cavitation intensity for various potential applications in future.

Two-dimensional simulation of intermediate-sized bubbles in low viscous liquids using counter diffusion lattice Boltzmann method

Energy Technology Data Exchange (ETDEWEB)

Ryu, Seungyeob, E-mail: syryu@kaeri.re.kr [Korea Atomic Energy Research Institute (KAERI), 1045 Daeduk-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Kim, Youngin; Kang, Hanok; Kim, Keung Koo [Korea Atomic Energy Research Institute (KAERI), 1045 Daeduk-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Ko, Sungho, E-mail: sunghoko@cnu.ac.kr [Department of Mechanical Design Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764 (Korea, Republic of)

2016-08-15

Highlights: • We directly simulate intermediate-sized bubbles in low viscous liquids. • The path instability and shape oscillation can be successfully simulated. • The motion of a pair bubble and bubble swarm is presented. • Bubbles with high-Reynolds-number can be simulated with under-resolved grids. • The counter diffusion multiphase method is feasible for the direct simulation of bubbly flows. - Abstract: The counter diffusion lattice Boltzmann method (LBM) is used to simulate intermediate-sized bubbles in low viscous liquids. Bubbles at high Reynolds numbers ranging from hundreds to thousands are simulated successfully, which cannot be done for the existing LBM versions. The characteristics of the path instability of two rising bubbles are studied for a wide range of Eotvos and Morton numbers. Finally, the study presented how bubble swarms move within the flow and how the flow surrounding the bubbles is affected by the bubble motions.

An equation of motion for bubble growth

Energy Technology Data Exchange (ETDEWEB)

Lesage, F.J. [College d' Enseignement General et Professionnel de L' Outaouais, Gatineau, Quebec (Canada). Dept. of Mathematics; Cotton, J.S. [McMaster University, Hamilton, ON (Canada). Dept. of Mechanical Engineering; Robinson, A.J. [Trinity College Dublin (Ireland). Dept. of Mechanical and Manufacturing Engineering

2009-07-01

A mathematical model is developed which describes asymmetric bubble growth, either during boiling or bubble injection from submerged orifices. The model is developed using the integral form of the continuity and momentum equations, resulting in a general expression for the acceleration of the bubble's centre of gravity. The proposed model highlights the need to include acceleration due to an asymmetric gain or loss of mass in order to accurately predict bubble motion. Some scenarios are posed by which the growth of bubbles, particularly idealized bubbles that remain a section of a sphere, must include the fact that bubble growth can be asymmetric. In particular, for approximately hemispherical bubble growth the sum of the forces acting on the bubble is negligible compared with the asymmetric term. Further, for bubble injection from a submerged needle this component in the equation of motion is very significant during the initial rapid growth phase as the bubble issues from the nozzle changing from a near hemisphere to truncated sphere geometry. (author)

Boiling crisis as inhibition of bubble detachment by the vapor recoil force

International Nuclear Information System (INIS)

Nikolayev, V.S.; Beysens, D.; Garrabos, Y.

2004-01-01

Boiling crisis is a transition between nucleate and film boiling. In this communication we present a physical model of the boiling crisis based on the vapor recoil effect. Our numerical simulations of the thermally controlled bubble growth at high heat fluxes show how the bubble begins to spread over the heater thus forming a germ for the vapor film. The vapor recoil force not only causes the vapor spreading, it also creates a strong adhesion to the heater that prevents the bubble departure, thus favoring the further bubble spreading. Near the liquid-gas critical point, the bubble growth is very slow and allows the kinetics of the bubble spreading to be observed. Since the surface tension is very small in this regime, only microgravity conditions can preserve a convex bubble shape. Under such conditions, we observed an increase of the apparent contact angle and spreading of the dry spot under the bubble, thus confirming our model of the boiling crisis. (authors)

A novel ultrasound based technique for classifying gas bubble sizes in liquids

International Nuclear Information System (INIS)

Hussein, Walid; Khan, Muhammad Salman; Zamorano, Juan; Espic, Felipe; Yoma, Nestor Becerra

2014-01-01

Characterizing gas bubbles in liquids is crucial to many biomedical, environmental and industrial applications. In this paper a novel method is proposed for the classification of bubble sizes using ultrasound analysis, which is widely acknowledged for being non-invasive, non-contact and inexpensive. This classification is based on 2D templates, i.e. the average spectrum of events representing the trace of bubbles when they cross an ultrasound field. The 2D patterns are obtained by capturing ultrasound signals reflected by bubbles. Frequency-domain based features are analyzed that provide discrimination between bubble sizes. These features are then fed to an artificial neural network, which is designed and trained to classify bubble sizes. The benefits of the proposed method are that it facilitates the processing of multiple bubbles simultaneously, the issues concerning masking interference among bubbles are potentially reduced and using a single sinusoidal component makes the transmitter–receiver electronics relatively simpler. Results from three bubble sizes indicate that the proposed scheme can achieve an accuracy in their classification that is as high as 99%. (paper)

Computing bubble-points of CO

NARCIS (Netherlands)

Ramdin, M.; Balaji, S.P.; Vicent Luna, J.M.; Torres-Knoop, A; Chen, Q.; Dubbeldam, D.; Calero, S; de Loos, T.W.; Vlugt, T.J.H.

2016-01-01

Computing bubble-points of multicomponent mixtures using Monte Carlo simulations is a non-trivial task. A new method is used to compute gas compositions from a known temperature, bubble-point pressure, and liquid composition. Monte Carlo simulations are used to calculate the bubble-points of

Characterization of intergranular fission gas bubbles in U-Mo fuel

International Nuclear Information System (INIS)

Kim, Y. S.; Hofman, G.; Rest, J.; Shevlyakov, G. V.

2008-01-01

This report can be divided into two parts: the first part, which is composed of sections 1, 2, and 3, is devoted to report the analyses of fission gas bubbles; the second part, which is in section 4, is allocated to describe the mechanistic model development. Swelling data of irradiated U-Mo alloy typically show that the kinetics of fission gas bubbles is composed of two different rates: lower initially and higher later. The transition corresponds to a burnup of ∼0 at% U-235 (LEU) or a fission density of ∼3 x 10 21 fissions/cm 3 . Scanning electron microscopy (SEM) shows that gas bubbles appear only on the grain boundaries in the pretransition regime. At intermediate burnup where the transition begins, gas bubbles are observed to spread into the intragranular regions. At high burnup, they are uniformly distributed throughout fuel. In highly irradiated U-Mo alloy fuel large-scale gas bubbles form on some fuel particle peripheries. In some cases, these bubbles appear to be interconnected and occupy the interface region between fuel and the aluminum matrix for dispersion fuel, and fuel and cladding for monolithic fuel, respectively. This is a potential performance limit for U-Mo alloy fuel. Microscopic characterization of the evolution of fission gas bubbles is necessary to understand the underlying phenomena of the macroscopic behavior of fission gas swelling that can lead to a counter measure to potential performance limit. The microscopic characterization data, particularly in the pre-transition regime, can also be used in developing a mechanistic model that predicts fission gas bubble behavior as a function of burnup and helps identify critical physical properties for the future tests. Analyses of grain and grain boundary morphology were performed. Optical micrographs and scanning electron micrographs of irradiated fuel from RERTR-1, 2, 3 and 5 tests were used. Micrographic comparisons between as-fabricated and as-irradiated fuel revealed that the site of

Numerical study of Taylor bubbles with adaptive unstructured meshes

Science.gov (United States)

Xie, Zhihua; Pavlidis, Dimitrios; Percival, James; Pain, Chris; Matar, Omar; Hasan, Abbas; Azzopardi, Barry

2014-11-01

The Taylor bubble is a single long bubble which nearly fills the entire cross section of a liquid-filled circular tube. This type of bubble flow regime often occurs in gas-liquid slug flows in many industrial applications, including oil-and-gas production, chemical and nuclear reactors, and heat exchangers. The objective of this study is to investigate the fluid dynamics of Taylor bubbles rising in a vertical pipe filled with oils of extremely high viscosity (mimicking the ``heavy oils'' found in the oil-and-gas industry). A modelling and simulation framework is presented here which can modify and adapt anisotropic unstructured meshes to better represent the underlying physics of bubble rise and reduce the computational effort without sacrificing accuracy. The numerical framework consists of a mixed control-volume and finite-element formulation, a ``volume of fluid''-type method for the interface capturing based on a compressive control volume advection method, and a force-balanced algorithm for the surface tension implementation. Numerical examples of some benchmark tests and the dynamics of Taylor bubbles are presented to show the capability of this method. EPSRC Programme Grant, MEMPHIS, EP/K0039761/1.

Research on the Conductivity-Based Detection Principles of Bubbles in Two-Phase Flows and the Design of a Bubble Sensor for CBM Wells.

Science.gov (United States)

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-09-17

The parameters of gas-liquid two-phase flow bubbles in field coalbed methane (CBM) wells are of great significance for analyzing coalbed methane output, judging faults in CBM wells, and developing gas drainage and extraction processes, which stimulates an urgent need for detecting bubble parameters for CBM wells in the field. However, existing bubble detectors cannot meet the requirements of the working environments of CBM wells. Therefore, this paper reports findings on the principles of measuring the flow pattern, velocity, and volume of two-phase flow bubbles based on conductivity, from which a new bubble sensor was designed. The structural parameters and other parameters of the sensor were then computed, the "water film phenomenon" produced by the sensor was analyzed, and the appropriate materials for making the sensor were tested and selected. After the sensor was successfully devised, laboratory tests and field tests were performed, and the test results indicated that the sensor was highly reliable and could detect the flow patterns of two-phase flows, as well as the quantities, velocities, and volumes of bubbles. With a velocity measurement error of ±5% and a volume measurement error of ±7%, the sensor can meet the requirements of field use. Finally, the characteristics and deficiencies of the bubble sensor are summarized based on an analysis of the measurement errors and a comparison of existing bubble-measuring devices and the designed sensor.

Research on the Conductivity-Based Detection Principles of Bubbles in Two-Phase Flows and the Design of a Bubble Sensor for CBM Wells

Directory of Open Access Journals (Sweden)

Chuan Wu

2016-09-01

Full Text Available The parameters of gas-liquid two-phase flow bubbles in field coalbed methane (CBM wells are of great significance for analyzing coalbed methane output, judging faults in CBM wells, and developing gas drainage and extraction processes, which stimulates an urgent need for detecting bubble parameters for CBM wells in the field. However, existing bubble detectors cannot meet the requirements of the working environments of CBM wells. Therefore, this paper reports findings on the principles of measuring the flow pattern, velocity, and volume of two-phase flow bubbles based on conductivity, from which a new bubble sensor was designed. The structural parameters and other parameters of the sensor were then computed, the “water film phenomenon” produced by the sensor was analyzed, and the appropriate materials for making the sensor were tested and selected. After the sensor was successfully devised, laboratory tests and field tests were performed, and the test results indicated that the sensor was highly reliable and could detect the flow patterns of two-phase flows, as well as the quantities, velocities, and volumes of bubbles. With a velocity measurement error of ±5% and a volume measurement error of ±7%, the sensor can meet the requirements of field use. Finally, the characteristics and deficiencies of the bubble sensor are summarized based on an analysis of the measurement errors and a comparison of existing bubble-measuring devices and the designed sensor.

Research on the Conductivity-Based Detection Principles of Bubbles in Two-Phase Flows and the Design of a Bubble Sensor for CBM Wells

Science.gov (United States)

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-01-01

The parameters of gas-liquid two-phase flow bubbles in field coalbed methane (CBM) wells are of great significance for analyzing coalbed methane output, judging faults in CBM wells, and developing gas drainage and extraction processes, which stimulates an urgent need for detecting bubble parameters for CBM wells in the field. However, existing bubble detectors cannot meet the requirements of the working environments of CBM wells. Therefore, this paper reports findings on the principles of measuring the flow pattern, velocity, and volume of two-phase flow bubbles based on conductivity, from which a new bubble sensor was designed. The structural parameters and other parameters of the sensor were then computed, the “water film phenomenon” produced by the sensor was analyzed, and the appropriate materials for making the sensor were tested and selected. After the sensor was successfully devised, laboratory tests and field tests were performed, and the test results indicated that the sensor was highly reliable and could detect the flow patterns of two-phase flows, as well as the quantities, velocities, and volumes of bubbles. With a velocity measurement error of ±5% and a volume measurement error of ±7%, the sensor can meet the requirements of field use. Finally, the characteristics and deficiencies of the bubble sensor are summarized based on an analysis of the measurement errors and a comparison of existing bubble-measuring devices and the designed sensor. PMID:27649206

Scales and structures in bubbly flows. Experimental analysis of the flow in bubble columns and in bubbling fluidized beds

NARCIS (Netherlands)

Groen, J.S.

2004-01-01

In this project a detailed experimental analysis was performed of the dynamic flow field in bubbly flows, with the purpose of determining local hydrodynamics and scale effects. Measurements were done in gas-liquid systems (air-water bubble columns) and in gas-solid systems (air-sand bubbing

Dark matter limits from a 15 kg windowless bubble chamber

International Nuclear Information System (INIS)

Szydagis, Matthew Mark

2010-01-01

The COUPP collaboration has successfully used bubble chambers, a technology previously applied only to high-energy physics experiments, as direct dark matter detectors. It has produced the world's most stringent spin-dependent WIMP limits, and increasingly competitive spin-independent limits. These limits were achieved by capitalizing on an intrinsic rejection of the gamma background that all other direct detection experiments must address through high-density shielding and empirically-determined data cuts. The history of COUPP, including its earliest prototypes and latest results, is briefly discussed in this thesis. The feasibility of a new, windowless bubble chamber concept simpler and more inexpensive in design is discussed here as well. The dark matter limits achieved with a 15 kg windowless chamber, larger than any previous COUPP chamber (2 kg, 4 kg), are presented. Evidence of the greater radiopurity of synthetic quartz compared to natural is presented using the data from this 15 kg device, the first chamber to be made from synthetic quartz. The effective reconstruction of the three-dimensional positions of bubbles in a highly distorted optical field, with ninety-degree bottom lighting similar to cloud chamber lighting, is demonstrated. Another innovation described in this thesis is the use of the sound produced by bubbles recorded by an array of piezoelectric sensors as the primary means of bubble detection. In other COUPP chambers, cameras have been used as the primary trigger. Previous work on bubble acoustic signature differentiation using piezos is built upon in order to further demonstrate the ability to discriminate between alpha- and neutron-induced events.

Two-Dimensional Physical and CFD Modelling of Large Gas Bubble Behaviour in Bath Smelting Furnaces

Directory of Open Access Journals (Sweden)

Yuhua Pan

2010-09-01

Full Text Available The behaviour of large gas bubbles in a liquid bath and the mechanisms of splash generation due to gas bubble rupture in high-intensity bath smelting furnaces were investigated by means of physical and mathematical (CFD modelling techniques. In the physical modelling work, a two-dimensional Perspex model of the pilot plant furnace at CSIRO Process Science and Engineering was established in the laboratory. An aqueous glycerol solution was used to simulate liquid slag. Air was injected via a submerged lance into the liquid bath and the bubble behaviour and the resultant splashing phenomena were observed and recorded with a high-speed video camera. In the mathematical modelling work, a two-dimensional CFD model was developed to simulate the free surface flows due to motion and deformation of large gas bubbles in the liquid bath and rupture of the bubbles at the bath free surface. It was concluded from these modelling investigations that the splashes generated in high-intensity bath smelting furnaces are mainly caused by the rupture of fast rising large gas bubbles. The acceleration of the bubbles into the preceding bubbles and the rupture of the coalescent bubbles at the bath surface contribute significantly to splash generation.