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Sample records for high-resistive bakelite rpc

  1. Influence of Temperature and Humidity on Bakelite Resistivity

    CERN Document Server

    Arnaldi, R; Barret, V; Bastid, N; Blanchard, G; Chiavassa, E; Cortese, P; Crochet, Philippe; Dellacasa, G; De Marco, N; Dupieux, P; Espagnon, B; Fargeix, J; Ferretti, A; Gallio, M; Lamoine, L; Luquin, Lionel; Manso, F; Mereu, P; Métivier, V; Musso, A; Oppedisano, C; Piccotti, A; Rahmani, A; Royer, L; Roig, O; Scalas, E; Scomparin, E; Vercellin, Ermanno

    1999-01-01

    Presentation made at RPC99 and submitted to Elsevier PreprintThe use of phenolic or melaminic bakelite as RPC electrodes is widespread. The electrode resistivity is an important parameter for the RPC performance. As recent studies have pointed out, the bakelite resistivity changes with temperature and is influenced by humidity. In order to gain a quantitative understanding on the influence of temperature and humidity on RPC electrodes, we assembled an apparatus to measure resistivity in well-controlled conditions. A detailed description of the experimental set-up as well as the first resistivity measurements for various laminates in different environmental conditions are presented.

  2. Final results from an extensive ageing test of bakelite Resistive Plate Chambers

    CERN Document Server

    Carboni, G; De Capua, S; Dominici, Daniele; Messi, R; Passaleva, G; Santovetti, E; Veltri, M

    2004-01-01

    We present the final results of an extensive aging test, performed at the CERN Gamma Irradiation Facility on two bakelite Resistive Plate Chambers (RPC) detectors. With a method based on a model describing the behaviour of an RPC under high particle flux conditions, we have periodically measured the electrode resistivity rho of the two RPC prototypes over 3 years. We observed a large spontaneous increase of rho with time, from the initial value of about 10**1**0 Omega cm to more than 200 multiplied by 10**1**0 Omega cm. A corresponding degradation of the RPC rate capabilities, from more than 3 kHz/cm**2 to less than 200 Hz/cm**2, was observed; the reversibility of the process, using a humid gas mixture, has also been studied. We also present a study of the effects of humidity on the bakelite resistivity using two 10 multiplied by 10 cm**2 bakelite samples.

  3. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2013-01-01

    During LS1, the Resistive Plate Chamber (RPC) collaboration is focusing its efforts on installation and commissioning of the fourth endcap station (RE4) and on the reparation and maintenance of the present system (1100 detectors). The 600 bakelite gaps, needed to build 200 double-gap RE4 chambers are being produced in Korea. Chamber construction and testing sites are located at CERN, in Ghent University, and at BARC (India). At present, 42 chambers have been assembled, 32 chambers have been successfully tested with cosmic rays runs and 7 Super Modules, made by two chambers, have been built at CERN by a Bulgarian/Georgian/Italian team and are now ready to be installed in the positive endcap. The 36 Super Modules needed to complete the positive endcap will be ready in September and installation is scheduled for October 2013. The Link-Board system for RE4 is under construction in Naples. Half of the system has been delivered at CERN in June. Six crates (Link-Board Boxes) and 75 boards, needed to instrument t...

  4. VT Boundaries - RPC polygons

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  5. Development and characterization of single gap glass RPC

    Energy Technology Data Exchange (ETDEWEB)

    Manisha, E-mail: manisha@pu.ac.in; Bhatnagar, V.; Shahi, J.S.; Singh, J.B.

    2016-12-21

    India-based Neutrino Observatory (INO) facility is going to have a 50 kton magnetized Iron CALorimeter (ICAL) detector for precision measurements of neutrino oscillations using atmospheric neutrinos. The proposed ICAL detector will be a stack of magnetized iron plates (acting as target material) interleaved with glass Resistive Plate Chambers (RPCs) as the active detector elements. An RPC is a gaseous detector made up of two parallel electrode plates having high bulk resistivity like that of a float glass and bakelite. For the ICAL detector, glass is preferred over bakelite as it does not need any kind of surface treatment to achieve better surface uniformity and also the cost of associated electronics is reduced. Under the detector R&D efforts for the proposed glass RPC detector, a few glass RPCs of 1 m × 1 m dimension are fabricated procuring glass of ∼2 mm thickness from one of the Indian glass manufacturers (Asahi). In the present paper, we report the characterization of RPC based on leakage current, muon detection efficiency and noise rate studies with varying gas compositions.

  6. MUON DETECTORS: RPC

    CERN Multimedia

    Pierluigi Paolucci

    2013-01-01

    In the second part of 2013 the two main activities of the RPC project are the reparation and maintenance of the present system and the construction and installation of the RE4 system. Since the opening of the barrel, repair activities on the gas, high-voltage and electronic systems are being done in parallel, in agreement with the CMS schedule. In YB0, the maintenance of the RPC detector was in the shadow of other interventions, nevertheless the scaffolding turned out to be a good solution for our gas leaks searches. Here we found eight leaking channels for about 100 l/h in total. 10 RPC/DT modules were partially extracted –– 90 cm –– in YB0, YB–1 and YB–2 to allow for the replacement of FE and LV distribution boards. Intervention was conducted on an additional two chambers on the positive endcap to solve LV and threshold control problems. Until now we were able to recover 0.67% of the total number of RPC electronic channels (1.5% of the channels...

  7. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2012-01-01

      2011 data-taking was very satisfactory for both the RPC detector and trigger. The RPC system ran very smoothly in 2011, showing an excellent stability and very high data-tacking efficiency. Data loss for RPC was about 0.37%, corresponding to 19 pb−1. Most of the performance studies, based on 2011 data, are now completed and the results have been already approved by CMS to be presented at the RPC 2012 conference (February 2012 at LNF). During 2011, the number of disconnected chambers increased from six to eight corresponding to 0.8% of the full system, while the single-gap-mode chambers increased from 28 to 31. Most of the problematic chambers are due to bad high-voltage connection and electronic failures that can be solved only during the 2013-2014 Long Shutdown. 98.4% of the electronic channels were operational. The average detection efficiency in 2011 was about 95%, which was the same value measured during the HV scan done at the beginning of the 2011 data-taking. Efficiency has be...

  8. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2011-01-01

    RPC detector calibration, HV scan Thanks to the high LHC luminosity and to the corresponding high number of muons created in the first part of the 2011 the RPC community had, for the first time, the possibility to calibrate every single detector element (roll).The RPC steering committee provided the guidelines for both data-taking and data analysis and a dedicated task force worked from March to April on this specific issue. The main goal of the RPC calibration was to study the detector efficiency as a function of high-voltage working points, fit the obtained “plateau curve” with a sigmoid function and determine the “best” high-voltage working point of every single roll. On 18th and 19th March, we had eight runs at different voltages. On 27th March, the full analysis was completed, showing that 60% of the rolls had already a very good fit with an average efficiency greater than 93% in the plateau region. To improve the fit we decided to take three more runs (15th April...

  9. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2011-01-01

    The RPC muon detector and trigger are working very well, contributing positively to the high quality of CMS data. Most of 2011 has been used to improve the stability of our system and the monitoring tools used online and offline by the shifters and experts. The high-voltage working point is corrected, chamber-by-chamber, for pressure variation since July 2011. Corrections are applied at PVSS level during the stand-by mode (no collision) and are not changed until the next fill. The single detector calibration, HV scan, of February and the P-correction described before were very important steps towards fine-tuning the stability of the RPC performances. A very detailed analysis of the RPC performances is now ongoing and from preliminary results we observe an important improvements of the cluster size stability in time. The maximum oscillation of the cluster size run by run is now about 1%. At the same time we are not observing the same stability in the detection efficiency that shows an oscillation of about ...

  10. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2013-01-01

      In 2013 the main activities of the RPC project are: maintenance and repair of the present system, RE4 chambers installation, and commissioning and upgrade of the online and offline software. About 25 FTE are working on the three items since January and will continue until the end of 2014. Three groups of physicists and technicians (HV, Gas and Front-End) are ready for the repair of the present system. Most of the equipment needed has been tested in the laboratory and is ready to be used at P5. The foreseen interventions have been included in the CMS schedule; they will begin in June 2013 and finish in summer 2014. DPG and Online experts are designing the upgrade of the RPC online and offline tools in order to integrate the new RE4 chambers and at the same time improve them using the experience from the 2010–2012 data-taking period. The RPC RE4 upgrade project is proceeding very well; it is on schedule and within the budget. 17 chambers have been built and tested at CERN, Ghent (Belg...

  11. MUON DETECTORS: RPC

    CERN Multimedia

    G. Iaselli

    2010-01-01

    During the technical stop, the RPC team was part of the CMS task force team working on bushing replacements in the Endcap cooling system, also validating the repairs in terms of connectivity (HV, LV and signal cables), and gas leak, on RE chambers. In parallel, the RPC team profited from the opportunity to cure several known problems: six chambers with HV problems (1 off + 5 single gaps) were recovered on both gaps; four known HV problems were localized at chamber level; additional temperature sensors were installed on cooling pipes on negative REs; one broken LV module in RE-1 was replaced. During the last month, the RPC group has made big improvements in the operations tools. New trigger supervisor software has substantially reduced the configuration time. Monitoring is now more robust and more efficient in providing prompt diagnostics. The detector has been under central DCS control for two weeks. Improvements have been made to both functionality and documentation and no major problems were found. Beam s...

  12. RPC gamma sensitivity simulation

    CERN Document Server

    Altieri, S; Bruno, G; Gianini, G; Merlo, M; Ratti, S P; Riccardi, C; Torre, P; Viola, L; Vitulo, P; Abbrescia, M; Colaleo, A; Iaselli, Giuseppe; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F; Salvemini, A

    2000-01-01

    A method to simulate resistive plate chambers (RPCs) gamma sensitivity has been developed using a Monte Carlo code. The sensitivity has been evaluated as a function of the gamma energy in the range 0.1-100 MeV and for different spectra. To evaluate the response of the detector in a Large Hadron Collider (LHC) background environment the gamma energy spectrum expected in the CMS muon barrel has been taken into account and the RPC gamma sensitivity evaluated as a function of the detector size. (3 refs).

  13. MUON DETECTORS: RPC

    CERN Multimedia

    G. Iaselli.

    Substantial progress has been made on the RPC system resulting in a high standard of operation. Impressive improvements have been made in the online software and DCS PVSS protocols that ensure robustness of the configuration phase and reliability of the detector monitoring tasks. In parallel, an important upgrade of CCU ring connectivity was pursued to avoid noise pick-up and consequent  data transmission errors during operation with magnetic field. While the barrel part is already well synchronized thanks to the long cosmics runs, some refinements are still required on the forward part. The "beam splashes" have been useful to cross check  the existing delay constants, but further efforts will be made as soon as a substantial sample of beam-halo events is available. Progress has been made on early detector performance studies. The RPC DQM tool is being extensively used and minor bugs have been found. More plots have been added and more people have been tr...

  14. MUON DETECTORS: RPC

    CERN Multimedia

    G. Iaselli

    The RPC group has invested a large effort in the study of trigger spikes observed during CRAFT data taking. The chambers are susceptible to noise generated by the flickering of fluorescent and projector lamps in the cavern (with magnetic field on). Soon after the end of CRAFT, it was possible to reproduce the phenomena using a waveform generator and to study possible modifications to be implemented in the grounding schema. Hardware actions have been already taken in order to reduce the detector sensitivity: star washers on the chamber front panels and additional shielding have been added where possible. During the shutdown maintenance activity many different problems were tackled on the barrel part. A few faulty high voltage connector/cable problems were fixed; now only two RPC chambers are left with single-gap mode operation. One chamber in YB+2 was replaced due to gas leakage. All the front-end electronic boards were replaced in 3 chambers (stations MB2 and MB3 in YB-2), that had been damaged after the coo...

  15. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2011-01-01

    During data-taking in 2010 the RPC system behaviour was very satisfactory for both the detector and trigger performances. Most of the data analyses are now completed and many results and plots have been approved in order to be published in the muon detector paper. A very detailed analysis of the detector efficiency has been performed using 60 million muon events taken with the dedicated RPC monitor stream. The results have shown that the 96.3% of the system was working properly with an average efficiency of 95.4% at 9.35 kV in the Barrel region and 94.9% at 9.55 kV in the Endcap. Cluster size goes from 1.6 to 2.2 showing a clear and well-known correlation with the strip pitch. Average noise in the Barrel is less than 0.4 Hz/cm2 and about 98% of full system has averaged noise less then 1 Hz/cm2. A linear dependence of the noise versus the luminosity has been preliminary observed and is now under study. Detailed chamber efficiency maps have shown a few percent of chambers with a non-uniform efficiency distribu...

  16. RPC High Voltage Scan 2015

    CERN Document Server

    CMS Collaboration

    2016-01-01

    During the LS1 the CMS RPC system has been upgraded with 144 new chambers installed on the forth endcap stations. An annual HV (RPC efficiency vs HV) scan for the entire RPC system has been performed during the Run2 data taking period in 2015. The obtained results have been compared to the HV scans performed in 2011 and 2012. No significant differences are observed in the compared results. The optimal HV working points for the newly installed chambers have been evaluated for the first time with collision data.

  17. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2012-01-01

    The RPC system is operating with a very high uptime, an average chamber efficiency of about 95% and an average cluster size around 1.8. The average number of active channels is 97.7%. Eight chambers are disconnected and forty are working in single-gap mode due to high-voltage problems. The total luminosity lost due to RPCs in 2012 is 88.46 pb–1. One of the main goals of 2012 was to improve the stability of the endcap trigger that is strongly correlated to the performances of the detector, due to the 3-out-3 trigger logic. At beginning of 2011 the instability of the detector efficiency was about 10%. Detailed studies found that this was mainly due to the strong correlation between the performance of the detector and the atmospheric pressure (P). Figure XXY shows the linear correlation between the average cluster size of the endcap chamber versus P. This effect is expected for gaseous detectors and can be reduced by correcting the applied high-voltage working point (HVapp) according to the followi...

  18. MUON DETECTORS: RPC

    CERN Multimedia

    G. Pugliese

    2010-01-01

    In the second half of 2010 run, the overall behavior of the RPC system has been very satisfactory, both in terms of detector and trigger performance. This result was achieved through interventions by skilled personnel and fine-tuned analysis procedures. The hardware was quite stable: both gas and power systems did not present significant problems during the data-taking period, confirming the high reliability achieved. Only few interventions on some HV or LV channels were necessary during the periodical technical accesses. The overall result is given by the stable percentage of active channels at about 98.5%. The single exception was at beginning of the ion collisions, when it dipped to 97.4% because of the failure of one LV module, although this was recovered after a few days. The control and monitoring software is now more robust and efficient, providing prompt diagnostics on the status of the entire system. Significant efforts were made in collaboration with the CMS cooling team to secure proper working ...

  19. MUON DETECTORS: RPC

    CERN Document Server

    G. Iaselli

    During the last 3 months the RPC group has made impressive improvements in the refinement of the operation tools and understanding of the detector. The full barrel and part of the plus end cap participated systematically to global runs producing millions of trigger on cosmics. The main monitoring tools were robust and efficient in controlling the detector and in diagnosis of problems. After the refinement of the synchronization procedure, detailed studies of the chamber performances, as a function of high voltage and front-end threshold, were pursued. In parallel, new tools for the prompt analysis were developed which have enabled a fast check of the data at the CMS Centre. This effort has been very valuable since it has helped in discovering many minor bugs in the reconstruction software and database which are now being fixed. Unfortunately, a large part of the RE2 station has developed increasing operational current. Some preliminary investigation leads to the conclusion that the serial gas circulation e...

  20. MUON DETECTORS: RPC

    CERN Multimedia

    P. Paolucci

    2012-01-01

      Since the start of data-taking in 2012, the RPCs have been operating in a stable manner with average chamber efficiencies above 95%. At present, the number of missing electronic channels is 1.2%; the number of disconnected chambers is 9, while 34 chambers are in single-gap mode. All those numbers are stable since the 2011 run. So far in 2012 no luminosity has been lost due to RPCs. During the winter shutdown, link board protections have been installed everywhere and are working properly, which makes the system more robust than before. A new “gas resistance” measurement campaign showed a clear stability of this parameter, which is proportional to the gap resistivity. No differences with respect to 2011 were found. A new efficiency calculation method has been validated, where now only DT/CSC segments of high quality that are associated with a stand-alone muon track are used to reduce the effect of punch-through segments. With this method, the observed oscillations in the RPC e...

  1. Recycling Waste Bakelite As A Carbon Resource In Ironmaking

    Directory of Open Access Journals (Sweden)

    James Ransford Dankwah

    2015-02-01

    Full Text Available Abstract Bakelite is a 3-dimensional cross-linked network structured thermosetting polymer which is difficult to recycle after use. However it contains high levels of carbon and CaCO3 that can be recovered for use as reductant and fluxing agent in ironmaking. In this work we report the use of post-consumer bakelite as reductant for the production of metallic iron from iron oxide in a horizontal tube furnace through the composite pellet approach.Gas emission studies were conducted by pyrolysing raw bakelite at different temperatures within the temperature range 1200-1600 C in a horizontal tube furnace. Following thiscomposite pellets were then formed from mixtures of iron oxide and post-consumer bakelite.The iron oxide-bakelite composites were heated from room temperature to 1200 C and then between 1200-1600 C in a continuous stream of pure argon and the off gas was analysed continuously using an infrared IR gas analyser. Elemental analyses of samples of the reduced metal were performed chemically for its oxygen content using a LECO oxygennitrogen analyser. The extent of reduction after ten minutes was determined from the oxygen content. Gas emission studies revealed the emission of large volumes of the reductant gases CO and CH4along with CO2.It is further demonstrated that post-consumer bakelite is effective at reducing iron oxide to produce metallic iron.

  2. Aging studies for the CMS RPC system

    CERN Document Server

    Eysermans, Jan

    2017-01-01

    Aging effects are studied for the Resistive Plate Chambers (RPC) at the Compact Muon Solenoid (CMS) experiment at the CERN Large Hadron Colider (LHC), which can manifest themselves during the High-Luminosity LHC (HL-LHC) running period. A dedicated consolidation program is set up using the CERN Gamma Irradiation Facility ++, where RPC detectors are exposed to a high gamma flux for a long term period equivalent to the HL-LHC operational time. Based on the past operational experience, the high background conditions are estimated and the RPC are tested under such circumstances. Several parameters are monitored as function of integrated charge and dedicated test beam periods allows measuring the detector efficiency as function of the background rate. In this work, an overview of the measurements which were performed for these studies is given. After having accumulated a significant amount of the total irradiation, no aging effects or degradation of the RPC detectors have been observed. These results suggest that ...

  3. Operation of low-noise single-gap RPC modules exposed to ionisation rates up to 1 kHz/cm$^2$

    CERN Document Server

    Cwiok, M; Dominik, Wojciech; Górski, M; Królikowski, J; 10.1016/j.nima.2004.06.123

    2004-01-01

    Two single gap medium-size RPC modules, made of bakelite plates of very good mechanical quality of the surface and having initial volume resistivity of 1 multiplied by 10**1**0 omegacm, were tested in the Gamma Irradiation Facility at CERN at ionisation rates up to 1 kHz/cm **3. The internal surfaces facing the gas volume of one RPC module were cladded with a thin layer of linseed oil varnish for comparison of oiled and non-oiled RPC operation. The results refer to the gas mixture of C//2H//2F //4/isobutane (97:3) with SF//6 addition below 1%. The single gap modules exhibited full detection efficiency plateau for the high voltage range of about 1 kV at full intensity of gamma rays. Good timing characteristics allowed to reach 95% efficiency at fully opened irradiation source with time window of 20 ns. The intrinsic noise rate for a non-oiled and an oiled RPC gap was, respectively, below 5 and 1 Hz/cm**2 at full efficiency over 1 k V voltage range.

  4. Bakelite chambers for time-of-flight measurements

    CERN Document Server

    Cwiok, M; Górski, M; Królikowski, J

    1999-01-01

    We report on the search of composite organic materials with the volume resistivity ranging from 10 sup 8 to 10 sup 1 sup 1 OMEGA cm. Materials having resistivity in this range may be used for electrodes of thin gap Parallel Plate Avalanche Chambers. Gas detectors of such structure and operated at increased gas pressure allow, potentially, a sub-nanosecond time resolution. Using bakelite-like material with electrical properties well tuned during manufacturing opens the possibility to overcome limitations related to the semi-conductive glass employed usually for ultrafast gas detectors of parallel plate structure for time-of-flight technique.

  5. The transformation of waste Bakelite to replace natural fine aggregate in cement mortar

    Directory of Open Access Journals (Sweden)

    Nopagon Usahanunth

    2017-06-01

    Full Text Available Bakelite material has been used to produce the various components for cars and consumer goods industry in Thailand. The growth of Bakelite consumption increases Bakelite waste. Bakelite waste is prohibited from disposing of direct landfilling and open burning because of the improper disposal and emission reasons. A large amount of this waste needs the large safe space of warehouse area for keeping which becomes a waste management problem. Size reduction by milling machine is helpful for waste handling and storing, however, the post-milling waste Bakelite plastic utilization shall be studied to maintain the waste storing capacity. There are some studies of the milling machine used for waste plastic size reduction. However, the particular study of milling machine application for waste size reduction and its milling waste utilization is still insufficient in Thailand. The purpose of this research is the use of waste Bakelite aggregate milling machine for Bakelite waste size reduction and use of the post-milling waste Bakelite as a fine aggregate to replace natural sand material in cement mortar. The waste Bakelite fine aggregate (WBFA was mixed in cement mortar mixture with the proportion 0% 20% 40% 60% 80% and 100% by volume for cement mortar sample preparation. The mortar sample was tested for compressive strength follow ASTM standard. The compressive test result of mortar samples will be compared between conventional mortar (0% WBFA and waste Bakelite mortar (WBM as well as comparing with the mortar standard. From an analysis of the sample test data found that the WBFA content in cement mortar mixture can predict the strength of WBM. The compressive strength of WBM at 28 days age with the fraction of WBFA is not exceeded 11.03%, and 23.08% respectively can be met the mortar standard according to the equation. The utilization of WBM to develop mortar non-structural mortar product can be usable from a technical point of view.

  6. The bakelite for the RPCs of the experiment CMS

    CERN Document Server

    Altieri, S; Bruno, G; Guida, R; Merlo, M; Ratti, S P; Riccardi, C; Torre, P; Vitulo, P; Mognaschi, E R; Abbrescia, M; Colaleo, A; Iaselli, Giuseppe; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F

    2000-01-01

    Results from aging tests on the bakelite used for the CMS RPCs are presented. Samples of melaminic bakelite were exposed to a heavy gamma and neutron radiation. Data on the bulk resistivity were collected while accumulating gamma and neutron doses and particles fluence up to values well beyond those expected in 10 years of RPCs operation in the barrel region of CMS. The test with gamma radiation was performed at the CERN Gamma Irradiation Facility (GIF) with a 20 Ci /sup 137/Cs source. A total absorbed dose of 5 Gy was accumulated during an irradiation period of about one month. The test with both neutron and gamma radiation was held at the Triga Mark II 250 kW reactor located in Pavia. A total of 80 h of exposure were accumulated integrating a neutron and gamma dose of about 80 Gy and a fast neutron fluence of some 10/sup 11/ cm/sup -2/. Experimental data on dose rate in both the test facilities have been compared to simulation output and show a good agreement. (4 refs).

  7. A new approach in modeling the response of RPC detectors

    CERN Document Server

    Benussi, L; Colafranceschi, S; Fabbri, F L; Giardoni, M; Passamonti, L; Piccolo, D; Pierluigi, D; Russo, A; Saviano, G; Buontempo, S; Cimmino, A; de Gruttola, M; Fabozzi, F; Iorio, A O M; Lista, L; Paolucci, P; Baesso, P; Belli, G; Pagano, D; Ratti, S P; Vicini, A; Vitulo, P; Viviani, C; Sharma, A; Bhattacharyya, A K

    2012-01-01

    The response of RPC detectors is highly sensitive to environmental variables. A novel approach is presented to model the response of RPC detectors in a variety of experimental conditions. The algorithm, based on Artificial Neural Networks, has been developed and tested on the CMS RPC gas gain monitoring system during commissioning.

  8. Data Management API within the GridRPC

    OpenAIRE

    Caniou, Yves; Caron, Eddy; Le Mahec, Gaël; Nakada, Hidemoto

    2011-01-01

    Copyright (c) Open Grid Forum (2006-2011). Some Rights Reserved. Distribution is unlimited.; standardization; This document follows the document produced by the GridRPC-WG on GridRPC Model and API for End-User applications. This new document aims to complete the GridRPC API with Data Management mechanisms and API.This document is not intended to provide features and capabilities for building data management middle- ware. Its goal is to complete the GridRPC set of functions and definitions to ...

  9. Data-driven performance evaluation method for CMS RPC trigger ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 79; Issue 4. Data-driven performance evaluation method for CMS ... The information transmitted from the three muon subsystems (DT, CSC and RPC) are collected by the Global Muon Trigger (GMT) Board and merged. A method for evaluating the RPC system trigger ...

  10. Experimental study on performance of imitative RPC for sulphate leaching

    Directory of Open Access Journals (Sweden)

    Xu-guang Tang

    2016-03-01

    Full Text Available This paper presents a manufacturing process to make an imitative RPC material. The blend was regularly composed of cement, silica fume, and certain content of rubber powder. The granular size distribution of dry blend was optimized to reduce the porosity of set material and the imitative RPC material was characterized by high silica fume content and with very low water to binder ratio. Furthermore, fine crushed aggregate and local natural medium crude sand were used to form mineral skeleton. Properties of various reference concrete series were investigated by conducting multiple tests, including permeability and mechanical strength test, the salt solution absorption test, the accelerated sulphate attack test, etc. The results show that the imitative RPC is an environmental-friendly civil engineering material which owns favorable mechanical strength, high impermeability and qualified excellent durability in sulphate contained environment.

  11. ATLAS RPC Quality Assurance results at INFN Lecce

    CERN Document Server

    INSPIRE-00211509; Borjanovic, I.; Cataldi, G.; Cazzato, A.; Chiodini, G.; Coluccia, M. R.; Creti, P.; Gorini, E.; Grancagnolo, F.; Perrino, R.; Primavera, M.; Spagnolo, S.; Tassielli, G.; Ventura, A.

    2006-01-01

    The main results of the quality assurance tests performed on the Resistive Plate Chamber used by the ATLAS experiment at LHC as muon trigger chambers are reported and discussed. Since July 2004, about 270 RPC units has been certified at INFN Lecce site and delivered to CERN, for being integrated in the final muon station of the ATLAS barrel region. We show the key RPC characteristics which qualify the performance of this detector technology as muon trigger chamber in the harsh LHC enviroments. These are dark current, chamber efficiency, noise rate, gas volume tomography, and gas leakage.

  12. RPC Detector Performance Results for 2016 and 2017

    CERN Document Server

    CMS Collaboration

    2018-01-01

    This note presents the summary of the RPC detector performance during 2017 and the comparison with 2016. A part of the performance results have been obtained with the tracker tracks extrapolation method, explained here. The data driven predictions of the RPC rates and integrated charge to the HL-LHC conditions have been presented as well. The results after the detailed background study of the effect of the newly installed shielding are shown. The history of the efficiency and cluster size vs time and instantaneous luminosity have been presented, as well.

  13. Data-driven performance evaluation method for CMS RPC trigger ...

    Indian Academy of Sciences (India)

    2012-10-06

    Oct 6, 2012 ... Data-driven performance evaluation method for CMS RPC trigger system using 2011 data at LHC. A SHARMA. ∗ and S B BERI, on behalf of the CMS Collaboration. Department of Physics, Panjab University, Chandigarh 160 014, India. ∗. Corresponding author. E-mail: archiesharma12@gmail.com.

  14. Detector Control System for CMS RPC at GIF++

    CERN Document Server

    Gul, Muhammad

    2016-01-01

    In the framework of the High Luminosity LHC upgrade program, the CMS muon groupbuilt several different RPC prototypes that are now under test at the new CERN Gamma Irradiation Facility (GIF++). A dedicated Detector Control System has been developed using the WinCC-OA tool to control and monitor these prototype detectors and to store the measured parameters data.

  15. A high-voltage test for the ATLAS RPC qualification

    CERN Document Server

    Aielli, G; Cardarelli, R; Di Ciaccio, A; Di Simone, A; Liberti, B; Santonico, R

    2004-01-01

    The RPC production sequence for the ATLAS experiment includes a specific test of current absorption at the operating point, which concerns the RPC "gas volumes", namely the bare detectors not yet assembled with the read-out panels and the mechanical support structures. The test, which is carried out at the production site, consists of two phases. The gas volumes are initially conditioned with pure argon, keeping the voltage constant just above the breakdown value of about 2 kV. The final test, performed after the volumes have undergone inner surface varnishing with linseed oil, is based on the measurement of the current-voltage characteristics with the binary operating gas, C//2H//2F//4/i-C//4H//1//0 = 95/5. The results presented here concern 45% of the total foreseen production.

  16. Summary of RPC 2007, the IX International Workshop

    CERN Document Server

    Sharma, Archana

    2009-01-01

    This summary highlights the success stories and open issues for the widely employed Resistive Plate Chamber (RPC). Many experiments were represented, each having its own specific requirements for the operation of the detector. The general focus is on the understanding of operational characteristics, namely studies of electrode material, gas systems, aging and long term performance. Simulations of electric field and transport parameters are reported, along with performance at high rates, focused on timing and time-of-flight systems. There are important issues related to operation of large RPC systems and their commissioning, QA and QC procedures. Finally, RPCs are now being used in diverse applications such as Calorimetry with analogue readout and in Astrophysics

  17. The durability of RPC with different content of silicon powder

    Science.gov (United States)

    Han, Weiwei; Sun, Tao; Li, Xinping; Chen, Youzhi; Song, Zhenglin; Sun, Mian

    2017-08-01

    The volume stability, freezing-thawing cycles, the resistance of chloride ions and sulfate attack of RPC with different content (0%, 40%, 100%) of silicon powder are investigated in this paper. The results demonstrate that the volume stability and the resistance of freezing-thawing for RPC with 40% silicon powder are improved because of a high compactness, whose shrinkage is only 350×10-6 for 60 d and tends to this value after 60 d, and the relative dynamic modulus is more than 99% after 300 times of freezing-thawing cycles. Meanwhile, with a high content of active SiO2 and a low magnesium content, the resistance of chloride ions and sulfate attack of RPC with 40% silicon powder are improved attributing to a high compact structure and a low level of magnesium sulfate attack. This leads an increase of the compressive strength with 5.6% after 150 times of wetting-drying cycles in the solution with 5% Na2SO4.

  18. Off-line time calibration of the ATLAS RPC system

    CERN Document Server

    Chiodini, G; The ATLAS collaboration

    2012-01-01

    Resistive Plate Chambers (RPC's), operated in saturated avalanche regime, are used in the Muon Spectrometer of the ATLAS experiment to produce the first level of the muon trigger in the central region, $|eta| <$ 1.05. The logic, based on a coincidence of hits in three layers of detector doublets, takes advantage of the very good time resolution of these detectors which allows to easily identify the LHC bunch crossing. The RPC readout electronics, based on a 320 MHz clock, allows to store a very granular time information, making potentially the RPC system the detector providing the most accurate time measurement in ATLAS. To fully exploit the intrinsic time resolution of detector and readout electronics a careful calibration of the system is needed, involving about 330,000 channels. The ATLAS data recorded during 2011 in LHC p-p collisions at $sqrt{s}$ = 7 TeV have been used to show that, after applying an offline calibration procedure, a time resolution uniform over the entire detector and stable in time c...

  19. The performance of RPCs with bakelite electrodes of resistivity under high radiation fluxes

    CERN Document Server

    Cwiok, M; Górski, M; Królikowski, J

    2000-01-01

    Three medium-size Resistive Plate Chambers (RPCs) with bakelite electrodes having resistivity of 5*10/sup 8/, 5*10/sup 9/ and 3*10 /sup 10/ Omega cm were tested in the Gamma Irradiation Facility at CERN in 1997, 1998 and 1999. The 2 mm gap modules working in an Inverted Double Gap configuration filled with gas mixtures containing freon C/sub 2/H/sub 2/F/sub 4/ and operated in avalanche mode exhibit wide efficiency plateau, good time resolution and small time walk due to rate variation even at intensities as high as 1 kHz/cm/sup 2//gap of a continuous radiation flux. (8 refs).

  20. R and D towards future CMS RPC upgrades

    CERN Document Server

    Fagot, A.; Cimmino, A; Gul, M.; Rios, A.A.O.; Tytgat, M.; Zaganidis, N.; Aly, S.; Assran, Y.; Radi, A.; Sayed, A.; Singh, G.; Abbrescia, M.; Iaselli, G.; Maggi, M.; Pugliese, G.; Verwilligen, P.; Van Doninck, W.; Colafranceschi, S.; Sharma, A.; Benussi, L.; Bianco, S.; Piccolo, D.; Primavera, F.; Bhatnagar, V.; Kumari, R.; Mehta, A.; Singh, J.; Ahmad, A.; Ahmed, W.; Asghar, M.I.; Awan, I.M.; Hoorani, H.R.; Muhammad, S.; Shah, M.A.; Shahzad, H.; Cho, S.W.; Choi, S.Y.; Hong, B.; Kang, M.H.; Lee, K.S.; Lim, J.H.; Park, S.K.; Kim, M.S.; Gouzevitch, M.; Grenier, G.; Lagarde, F.; Laktineh, I.B.; Bernardino, S.Carpinteyro; Estrada, C.Uribe; Pedraza, I.; Carrillo Moreno, S.; Vazquez Valencia, F.; Pant, L.M.; Buontempo, S.; Cavallo, N.; Esposito, M.; Fabozzi, F.; Lanza, G.; Orso, I.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Thyssen, F.; Braghieri, A.; Magnani, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Ban, Y.; Qian, S.J.; Choi, M.; Choi, Y.; Goh, J.; Kim, D.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Bagaturia, I.; Lomidze, D.; Avila, C.; Cabrera, A.; Sanabria, J.C.; Crotty, I.; Vaitkus, J.

    2016-09-26

    High pseudo-rapidity region of CMS muon system is covered only by Cathode Strip Chambers (CSC) and lacks redundant coverage despite the fact that it is a challenging region for muons in terms of backgrounds and momentum resolution. In order to maintain good efficiency for the muon trigger in this region additional RPC are planned to be installed in stations RE31 and RE41. The stations will use RPCs with lower granularity but good timing resolution to mitigate background effects and complete the redundancy of the system. R and D activities will be presented in the talk.

  1. The slow control system of the HADES RPC wall

    Science.gov (United States)

    Gil, A.; Blanco, A.; Castro, E.; Díaz, J.; Garzón, J. A.; Gonzalez-Diaz, D.; Fouedjio, L.; Kolb, B. W.; Palka, M.; Traxler, M.; Trebacz, R.; Zumbruch, P.

    2012-01-01

    The control and monitoring system for the new HADES RPC time of flight wall installed at GSI Helmholtzzentrum für Schwerionenforschung GmbH (Darmstadt, Germany), is described. The slow control system controls/monitors about 6000 variables from different physical devices via a distributed architecture, which uses intensively the 1-wire® bus. The software implementation is based on the Experimental Physics and Industrial Control System (EPICS) software tool kit providing low cost, reliability and adaptability without requiring large hardware resources.The control and monitoring system attends five different subsystems: front-end electronics, low voltage, high voltage, gases, and detector.

  2. Charge Distribution Dependency on Gap Thickness of CMS Endcap RPC

    CERN Document Server

    Park, Sung K.; Lee, Kyongsei

    2016-01-01

    We report a systematic study of charge distribution dependency of CMS Resistive Plate Chamber (RPC) on gap thickness. Prototypes of double-gap RPCs with six different gap thickness ranging from from 1.0 to 2.0 mm in 0.2-mm steps have been built with 2-mm-thick phenolic high-pressure-laminated plates. The efficiencies of the six gaps are measured as a function of the effective high voltages. We report that the strength of the electric fields of the gap is decreased as the gap thickness is increased. The distributions of charges in six gaps are measured. The space charge effect is seen in the charge distribution at the higher voltages. The logistic function is used to fit the charge distribution data. Smaller charges can be produced within smaller gas gap. But the digitization threshold should be also lowered to utilize these smaller charges.

  3. Charge distribution dependency on gap thickness of CMS endcap RPC

    CERN Document Server

    Park, Sung Keun

    2016-01-01

    We present a systematic study of charge distribution dependency of CMS Resistive Plate Chamber (RPC) on gap thickness.Prototypes of double-gap with five different gap thickness from 1.8mm to 1.0mm in 0.2mm steps have been built with 2mm thick phenolic high-pressure-laminated (HPL) plates. The charges of cosmic-muon signals induced on the detector strips are measured as a function of time using two four-channel 400-MHz fresh ADCs. In addition, the arrival time of the muons and the strip cluster sizes are measured by digitizing the signal using a 32-channel voltage-mode front-end-electronics and a 400-MHz 64-channel multi-hit TDC. The gain and the input impedance of the front-end-electronics were 200mV/mV and 20 Ohm, respectively.

  4. First results of CMS RPC performance at 13 TeV

    CERN Document Server

    Pedraza-Morales, M.I.; Shopova, M.

    2016-12-01

    The muon spectrometer of the CMS (Compact Muon Solenoid) experiment at the Large Hadron Collider (LHC) is equipped with a redundant system made of Resistive Plate Chambers (RPCs) and Drift Tube (DT) chambers in the barrel, RPC and Cathode Strip Chambers (CSCs) in the endcap region. In this paper, the first results of the performance of the RPC system during 2015 with the LHC running at 13 TeV is presented. The stability of the RPC performance, in terms of efficiency, cluster size and noise, is reported.

  5. High-speed phase modulation using the RPC method with a digital micromirror-array device

    Science.gov (United States)

    Rodrigo, Peter John; Perch-Nielsen, Ivan R.; Glückstad, Jesper

    2006-06-01

    An improved implementation of the reverse phase contrast (RPC) method for rapid optical transformation of amplitude patterns into spatially similar phase patterns using a high-speed digital micromirror-array device (DMD) is presented. Aside from its fast response, the DMD also provides an electronically adjustable and inherently aligned input iris that simplifies the optimization of the RPC system. In the RPC optimization, we illustrate good agreement between experimentally obtained and theoretically predicted optimal iris size. Finally, we demonstrate the conversion of a binary amplitude grating encoded on the DMD into a binary (0-π) phase grating.

  6. Electronic system of the RPC Muon Trigger in CMS experiment at LHC accelerator (Elektroniczny system trygera mionowego RPC w eksperymencie CMS akceleratora LHC

    CERN Document Server

    Bialkowska, H

    2009-01-01

    This paper presents implementation of distributed, multichannel electronic measurement system for RPC - based Muon Trigger in the CMS experiment at LHC. The introduction shortly describes the research aims of LHC and shows the metrological requirements for CMS - good spatial and time resolution, and possibility to estimate multiple physical parameters from registered collisions of particles. Further the paper describes RPC Muon Trigger consisting of 200 000 independent channels for position measurement. The first part of the paper presents the functional structure of the system in the context of requirements put by the CMS experiment, like global triggering system and data acquisition. The second part describes the hardware solutions used in particular parts of the RPC detector measuremnt system and shows some test results. The paper has a digest and overview nature.

  7. CMS RPC muon detector performance with 2010-2012 LHC data

    CERN Document Server

    INSPIRE-00316302; Ban, Y.; Cai, J.; Li, Q.; Liu, S.; Qian, S.; Wang, D.; Xu, Z.; Zhang, F.; Choi, Y.; Kim, D.; Goh, J.; Choi, S.; Hong, B.; Kang, J.W.; Kang, M.; Kwon, J.H.; Lee, K.S.; Lee, S.K.; Park, S.K.; Pant, L.M.; Mohanty, A.K.; Chudasama, R.; Singh, J.B.; Bhatnagar, V.; Mehta, A.; Kumar, R.; Cauwenbergh, S.; Costantini, S.; Cimmino, A.; Crucy, S.; Fagot, A.; Garcia, G.; Ocampo, A.; Poyraz, D.; Salva, S.; Thyssen, F.; Tytgat, M.; Zaganidis, N.; Doninck, W.V.; Cabrera, A.; Chaparro, L.; Gomez, J.P.; Gomez, B.; Sanabria, J.C.; Avila, C.; Ahmad, A.; Muhammad, S.; Shoaib, M.; Hoorani, H.; Awan, I.; Ali, I.; Ahmed, W.; Asghar, M.I.; Shahzad, H.; Sayed, A.; Ibrahim, A.; Aly, S.; Assran, Y.; Radi, A.; Elkafrawy, T.; Sharma, A.; Colafranceschi, S.; Abbrescia, M.; Calabria, C.; Colaleo, A.; Iaselli, G.; Loddo, F.; Maggi, M.; Nuzzo, S.; Radogna, R.; Venditti, R.; Verwilligen, P.; Benussi, L.; Bianco, S.; Piccolo, D.; Paolucci, P.; Buontempo, S.; Cavallo, N.; Merola, M.; Fabozzi, F.; Iorio, O.M.; Braghieri, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vitulo, P.; Vai, I.; Magnani, A.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Aleksandrov, A.; Genchev, V.; Iaydjiev, P.; Rodozov, M.; Sultanov, G.; Vutova, M.; Stoykova, S.; Hadjiiska, R.; Ibargüen, H.S.; Morales, M.I.P.; Bernardino, S.C.; Bagaturia, I.; Tsamalaidze, Z.; Crotty, I.; Kim, M.S.

    2014-12-05

    The muon spectrometer of the CMS (Compact Muon Solenoid) experiment at the Large Hadron Collider (LHC) is equipped with a redundant system made of Resistive Plate Chambers and Drift Tube in barrel and RPC and Cathode Strip Chamber in endcap region. In this paper, the operations and performance of the RPC system during the first three years of LHC activity will be reported. The integrated charge was about 2 mC/cm$^{2}$, for the most exposed detectors. The stability of RPC performance, with particular attention on the stability of detector performance such as efficiency, cluster size and noise, will be reported. Finally, the radiation background levels on the RPC system have been measured as a function of the LHC luminosity. Extrapolations to the LHC design conditions and HL-LHC are also discussed.

  8. The RPC-based IFR system at BaBar experiment preliminary results

    CERN Document Server

    Piccolo, D; Bagnasco, S; Baldini, R; Band, H R; Bionta, R; Buzzo, A; Calcaterra, A; Cavallo, N; Contri, R; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Fabozzi, F; Falciai, D; Finocchiaro, G; Gatto, C; Johnson, J; Lista, L; Lo Vetere, M; Macri, M; Monge, R; Palano, A; Paolucci, P; Passaggio, S; Patrignani, C; Patteri, P; Peruzzi, I; Piccolo, M; Robutti, E; Santroni, A; Sciacca, C; Wright, D; Yu, Z; Zallo, A

    2002-01-01

    The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported.

  9. Detector control system and efficiency performance for CMS RPC at GIF++

    Science.gov (United States)

    Gul, M.; Gonzalez Blanco, G.; Cimmino, A.; Crucy, S.; Fagot, A.; Rios, A. A. O.; Tytgat, M.; Zaganidis, N.; Aly, S.; Assran, Y.; Radi, A.; Sayed, A.; Singh, G.; Abbrescia, M.; Iaselli, G.; Maggi, M.; Pugliese, G.; Verwilligen, P.; Doninck, W. V.; Colafranceschi, S.; Sharma, A.; Benussi, L.; Bianco, S.; Piccolo, D.; Primavera, F.; Bhatnagar, V.; Kumari, R.; Mehta, A.; Singh, J.; Ahmad, A.; Asghar, M. I.; Muhammad, S.; Awan, I. M.; Hoorani, H. R.; Ahmed, W.; Shahzad, H.; Shah, M. A.; Cho, S. W.; Choi, S. Y.; Hong, B.; Kang, M. H.; Lee, K. S.; Lim, J. H.; Park, S. K.; Kim, M. S.; Goutzvitz, M.; Grenier, G.; Lagarde, F.; Lagarde, F.; Estrada, C. U.; Pedraza, I.; Severiano, C. B.; Carrillo Moreno, S.; Vazquez Valencia, F.; Pant, L. M.; Buontempo, S.; Cavallo, N.; Esposito, M.; Fabozzi, F.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Orso, I.; Paolucci, P.; Thyssen, F.; Braghieri, A.; Magnani, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Ban, Y.; Qian, S. J.; Choi, M.; Choi, Y.; Goh, J.; Kim, D.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Lomidze, D.; Bagaturia, I.; Avila, C.; Cabrera, A.; Sanabria, J. C.; Crotty, I.; Vaitkus, J.; CMS Collaboration

    2016-10-01

    In the framework of the High Luminosity LHC upgrade program, the CMS muon group built several different RPC prototypes that are now under test at the new CERN Gamma Irradiation Facility (GIF++). A dedicated Detector Control System (DCS) has been developed using the WinCC-OA tool to control and monitor these prototype detectors and to store the measured parameters data. Preliminary efficiency studies that set the base performance measurements of CMS RPC for starting aging studies are also presented.

  10. Comparison Study of Axial Behavior of RPC-CFRP Short Columns

    Directory of Open Access Journals (Sweden)

    Taghreed Khaleefa Mohammed Ali

    2015-05-01

    Full Text Available In this paper, the axial behaviors of reactive powder     concrete (RPC short  columns confined with carbon fiber reinforced polymer (CFRP were   investigated. All the specimens have square cross section of 100 mm × 100   mm and length of 400 mm with aspect ratio 4. The experimental work consists   of three groups. The first group consists of six specimens of RPC with 2%  micro steel fiber, without ordinary reinforcing steel and confining by zero, one and two layer of CFRP respectively. The second group consists of six    specimens of RPC with 2% micro steel fiber and minimum ordinary reinforcing  steel and confining by zero, one and two layers of CFRP respectively. The third  group consists of four specimens of RPC without micro steel fiber and ordinary  reinforcing steel and confining by one and two layers of CFRP respectively.  Experimental data for strength, longitudinal and lateral displacement and  failure mode were obtained for each test. The toughness (area under the curve  for each test was obtained by using numerical integration. The RPC columns confined with CFRP showed stiffer behavior compared with RPC columns without CFRP. The ultimate load of the RPC columns with 2% micro steel  fiber + two layers of CFRP + minimum ordinary reinforcement were more than that of the RPC columns with 2% micro steel fiber + minimum ordinary   reinforcement and without CFRP by about 1.333.

  11. Retrofitting of Reinforced Concrete Beams using Reactive Powder Concrete (RPC)

    Science.gov (United States)

    Karthik, S.; Sundaravadivelu, Karthik

    2017-07-01

    Strengthening of existing damaged structures is one of the leading studies in civil engineering. The purpose of retrofitting is to structurally treat the member with an aim to restore the structure to its original strength. The focus of this project is to study the behaviour of damaged Reinforced Concrete beam retrofitted with Reactive Powder Concrete (RPC) Overlay. Reinforced concrete beams of length 1200 mm, width 100 mm and depth 200 mm were casted with M30 grade of concrete in the laboratory and cured for 28 days. One beam is taken as control and are tested under two point loading to find out ultimate load. Remaining beams are subjected to 90 % ultimate load of control beams. The partially damaged beams are retrofitted with Reactive Powder Concrete Overlay at the full tension face of the beam and side overlay depends upon the respectable retrofitting techniques with 10 mm and 20 mm thick layer to find optimum. Materials like steel fibres are added to enhance the ductility by eliminating coarse particle for homogeneity of the structure. Finally, the modes of failure for retrofitted beams are analysed experimentally under two point loading & compared the results with Control beam.

  12. An Emergency Georeferencing Framework for GF-4 Imagery Based on GCP Prediction and Dynamic RPC Refinement

    Directory of Open Access Journals (Sweden)

    Pengfei Li

    2017-10-01

    Full Text Available GaoFen-4 (GF-4 imagery has very potential in terms of emergency response due to its gazing mode. However, only poor geometric accuracy can be obtained using the rational polynomial coefficient (RPC parameters provided, making ground control points (GCPs necessary for emergency response. However, selecting GCPs is traditionally time-consuming, labor-intensive, and not fully reliable. This is mainly due to the facts that (1 manual GCP selection is time-consuming and cumbersome because of too many human interventions, especially for the first few GCPs; (2 typically, GF-4 gives planar array imagery acquired at rather large tilt angles, and the distortion introduces problems in image matching; (3 reference data will not always be available, especially under emergency circumstances. This paper provides a novel emergency georeferencing framework for GF-4 Level 1 imagery. The key feature is GCP prediction based on dynamic RPC refinement, which is able to predict even the first GCP and the prediction will be dynamically refined as the selection goes on. This is done by two techniques: (1 GCP prediction using RPC parameters and (2 dynamic RPC refinement using as few as only one GCP. Besides, online map services are also adopted to automatically provide reference data. Experimental results show that (1 GCP predictions improve using dynamic RPC refinement; (2 GCP selection becomes more efficient with GCP prediction; (3 the integration of online map services constitutes a good example for emergency response.

  13. Study of gas contaminants and interaction with materials in RPC closed loop system

    CERN Document Server

    Colafranceschi, S; Benussi, L.; Bianco, S.; Passamonti, L.; Piccolo, D.; Pierluigi, D.; Russo, A.; Ferrini, M.; Greci, T.; Saviano, G.; Vendittozzi, C.; Abbrescia, M.; Calabria, C.; Colaleo, A.; Iaselli, G.; Maggi, M.; Nuzzo, S.; Pugliese, G.; Verwilligen, P.; Sharma, A.

    2013-01-01

    Resistive Plate Counters (RPC) detectors at the Large Hadron Collider (LHC) experiments use gas recirculation systems to cope with large gas mixture volumes and costs. In this paper a long-term systematic study about gas purifiers, gas contaminants and detector performance is discussed. The study aims at measuring the lifetime of purifiers with new and used cartridge material along with contaminants release in the gas system. During the data-taking the response of several RPC double-gap detectors was monitored in order to characterize the correlation between dark currents, filter status and gas contaminants.

  14. A study of gas contaminants and interaction with materials in RPC closed loop systems

    CERN Document Server

    Colafranceschi, S.; Benussi, L.; Bianco, S.; Passamonti, L.; Piccolo, D.; Pierluigi, D.; Russo, A.; Ferrini, M.; Greci, T.; Saviano, G.; Vendittozzi, C.; Abbrescia, M.; Calabria, C.; Colaleo, A.; Iaselli, G.; Maggi, M.; Nuzzo, S.; Pugliese, G.; Verwilligen, P.; Sharma, A.

    2012-01-01

    Resistive Plate Counters (RPC) detectors at the Large Hadron Collider (LHC) experiments use gas recirculation systems to cope with large gas mixture volumes and costs. In this paper a long-term systematic study about gas purifiers, gas contaminants and detector performance is discussed. The study aims at measuring the lifetime of purifiers with unused and used cartridge material along with contaminants release in the gas system. During the data-taking the response of several RPC double-gap detectors was monitored in order to characterize the correlation between dark currents, filter status and gas contaminants.

  15. Performance of the prototype gas recirculation system with built-in RGA for INO RPC system

    Energy Technology Data Exchange (ETDEWEB)

    Bhuyan, M. [Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Datar, V.M. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Joshi, A. [Alpha Pneumatics, 11-Krishna Kutir, Madanlal Dhingra Road, Thane 400602 (India); Kalmani, S.D., E-mail: kalmani@tifr.res.in [Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Mondal, N.K. [Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Rahman, M.A. [Department of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Satyanarayana, B.; Verma, P. [Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India)

    2012-01-01

    An open loop gas recovery and recirculation system has been developed for the INO RPC system. The gas mixture coming from RPC exhaust is first desiccated by passing through molecular sieve (3 Angstrom-Sign +4 Angstrom-Sign ). Subsequent scrubbing over basic active alumina removes toxic and acidic contaminants. The Isobutane and Freon are then separated by diffusion and liquefied by fractional condensation by cooling up to -26{sup Ring-Operator }C. A Residual Gas Analyser (RGA) is being used in the loop to study the performance of the recirculation system. The results of the RGA analysis will be discussed.

  16. The inclusion of RPC only segments in the Barrel Muon Track Finder

    CERN Document Server

    CMS Collaboration

    2018-01-01

    On November 3, 2017 during the LHC fill 6360 and from the run number 306121 RPC-only segments were enable to trigger. In this document we show the impact of the RPC-only segments in the Barrel Muon Track Finder efficiency performance. The efficiency measurement was done with Tag and Probe cut and count following the Muon POG working point recommendations (tight ID and Particle Flow isolation requirements more details can be found in https://cds.cern.ch/record/2054113). The used dataset was ZMuMu corresponding to each period.

  17. High rate, fast timing Glass RPC for the high $\\eta$ CMS muon detectors

    CERN Document Server

    INSPIRE-00185093; Lagarde, François; Laktineh, Imad; Buridon, Victor; Chen, Xiushan; Combaret, Christophe; Eynard, Alexis; Germani, Lionel; Grenier, Gerald; Mathez, Hervé; Mirabito, Laurent; Petrukhin, Alexei; Steen, Arnaud; Tromeur, William; Wang, Yi; Gong, A.; Moreau, Nathalie; de la Taille, Christophe; Dulucq, Fréderic

    2017-02-11

    The HL-LHC phase is designed to increase by an order of magnitude the amount of data to be collected by the LHC experiments. To achieve this goal in a reasonable time scale the instantaneous luminosity would also increase by an order of magnitude up to $6 \\cdot 10^{34}$ cm$^{-2}$s$^{-1}$. The region of the forward muon spectrometer ($|\\eta| > 1.6$) is not equipped with RPC stations. The increase of the expected particles rate up to 2 kHz/cm$^2$ ( including a safety factor 3 ) motivates the installation of RPC chambers to guarantee redundancy with the CSC chambers already present. The actual RPC technology of CMS cannot sustain the expected background level. A new generation Glass-RPC (GRPC) using low resistivity glass (LR) is proposed to equip at least the two most far away of the four high eta muon stations of CMS. The design of small size prototypes and the studies of their performances under high rate particles flux is presented.

  18. R&D; towards future upgrade of the CMS RPC system

    CERN Document Server

    Pugliese, Gabriella

    2016-01-01

    The CMS experiment at the CERN Large Hadron Collider (LHC) is equipped with a redundant muon trigger system based on Drift Tubes Chambers (DT) in the barrel region and Cathode Strip Chamber (CSC) in the endcap regions and Resistive Plate Chambers (RPC) in both regions up to | η | = 1.6. In view of the High Luminosity LHC (HL-LHC) phase, to keep the same muon performance new muon stations will be installed in the forward region (1.6< | η | <2.4) and in the very forward region up to | η | = 2.8. The 3th and 4th stations will be equipped with a new generation of RPC with improved performance (iRPC), capable of handling the challenging con- ditions expected at the HL-LHC. An extensive R&D; program has been undertaken to define the detector design and related electronics that meet the HL-LHC requirements. A summary of iRPC performance results is here reported.

  19. High rate, fast timing Glass RPC for the high ${\\eta}$ CMS muon detectors

    CERN Document Server

    INSPIRE-00430500; Gouzevitch, M.; Laktineh, I.; Buridon, V.; Chen, X.; Combaret, C.; Eynard, A.; Germani, L.; Grenier, G.; Mathez, H.; Mirabito, L.; Petrukhin, A.; Steen, A.; Tromeur, W.; Wang, Y.; Gong, A.; Moreau, N.; de la Taille, C.; Dulucq, F.; Cimmino, A.; Crucy, S.; Fagot, A.; Gul, M.; Rios, A.A.O.; Tytgat, M.; Zaganidis, N.; Aly, S.; Assran, Y.; Radi, A.; Sayed, A.; Singh, G.; Abbrescia, M.; Iaselli, G.; Maggi, M.; Pugliese, G.; Verwilligen, P.; Van Doninck, W.F.; Colafranceschi, S.; Sharmag, A.; Benussi, L.; Bianco, S.; Piccolo, D.; Primavera, F.; Bhatnagar, V.; Kumari, R.; Mehta, A.; Singh, J.; Ahmad, A.; Ahmed, W.; Asghar, M.I.; Awan, I.M.; Hoorani, R.; Muhammad, S.; Shahzad, H.; Shah, M.A.; Cho, S.W.; Choi, S.Y.; Hong, B.; Kang, M.H.; Lee, K.S.; Lim, J.H.; Park, S.K.; Kim, M.S.; Carpinteyro Bernardino, S.; Pedraza, I.; Uribe Estradam, C.; Carrillo Moreno, S.; Vazquez Valencia, F.; Pant, L.M.; Buontempo, S.; Cavallo, N.; Esposito, M.; Fabozzi, F.; Lanza, G.; Orso, I.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Thyssen, F.; Braghieri, A.; Magnani, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Ban, Y.; Qian, S.J.; Choi, M.; Choi, Y.; Goh, J.; Kim, D.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Bagaturia, I.; Lomidze, D.; Avila, C.; Cabrera, A.; Sanabria, J.C.; Crotty, I.; Vaitkus, J.

    2016-09-09

    The HL-LHC phase is designed to increase by an order of magnitude the amount of data to be collected by the LHC experiments. To achieve this goal in a reasonable time scale the instantaneous luminosity would also increase by an order of magnitude up to $6.10^{34} cm^{-2} s^{-1}$ . The region of the forward muon spectrometer ($|{\\eta}| > 1.6$) is not equipped with RPC stations. The increase of the expected particles rate up to $2 kHz/cm^{2}$ (including a safety factor 3) motivates the installation of RPC chambers to guarantee redundancy with the CSC chambers already present. The actual RPC technology of CMS cannot sustain the expected background level. The new technology that will be chosen should have a high rate capability and provides a good spatial and timing resolution. A new generation of Glass-RPC (GRPC) using low-resistivity (LR) glass is proposed to equip at least the two most far away of the four high ${\\eta}$ muon stations of CMS. First the design of small size prototypes and studies of their perfor...

  20. Detector Control System and Efficiency Performance for CMS RPC at GIF++

    CERN Document Server

    Gul, Muhammad; Cimmino, A; Crucy, S; Fagot, A; Rios, A A O; Tytgat, M; Zaganidis, N; Aly, S; Assran, Y; Radi, A; Sayed, A; Singh, G; Abbrescia, M; Iaselli, G; Maggi, M; Pugliese, G; Verwilligen, P; Doninck, W V; Colafranceschi, S; Sharma, A; Benussi, L; Bianco, S; Piccolo, D; Primavera, F; Bhatnagar, V; Kumari, R; Mehta, A; Singh, J; Ahmad, A; Asghar, M I; Muhammad, S; Awan, I A; Hoorani, H R; Ahmed, W; Shahzad, H; Shah, M A; Cho, S W; Choi, S Y; Hong, B; Kang, M H; Lee, K S; Lim, J H; Park, S K; Kim, M; Goutzvitz, M; Grenier, G; Lagarde, F; Estrada, C U; Pedraza, I; Severiano, C B; Carrillo Moreno, S; Vazquez Valencia, F; Pant, L M; Buontempo, S; Cavallo, N; Esposito, M; Fabozzi, F; Lanza, G; Lista, L; Meola, S; Merola, M; Orso, I; Paolucci, P; Thyssen, F; Braghieri, A; Magnani, A; Montagna, P; Riccardi, C; Salvini, P; Vai, I; Vitulo, P; Ban, Y; Qian, S J; Choi, M; Choi, Y; Goh, J; Kim, D; Aleksandrov, A; Hadjiiska, R; Iaydjiev, P; Rodozov, M; Stoykova, S; Sultanov, G; Vutova, M; Dimitrov, A; Litov, L; Pavlov, B; Petkov, P; Lomidze, D; Bagaturia, I; Avila, C; Cabrera, A; Sanabria, J C; Crotty, I; Vaitkus, J

    2016-01-01

    In the framework of the High Luminosity LHC upgrade program, the CMS muon group built several different RPC prototypes that are now under test at the new CERN Gamma Irradiation Facility (GIF++). A dedicated Detector Control System has been developed using the WinCC-OA tool to control and monitor these prototype detectors and to store the measured parameters data.

  1. Installation of last DT+RPC packages for the muon barrel detector of CMS

    CERN Multimedia

    Jesus Puerta-Pelayo

    2007-01-01

    On friday 26 October 2007 the last BMu package (DT+RPC chambers) was installed in the cavern into the iron yoke of CMS. This operation marked the completion of the central muon detector of CMS. Some pictures of this last installation round (8 chambers in total in YB-2 and YB-1) are shown here.

  2. Charging of highly resistive granular metal films

    Science.gov (United States)

    Orihuela, M. F.; Ortuño, M.; Somoza, A. M.; Colchero, J.; Palacios-Lidón, E.; Grenet, T.; Delahaye, J.

    2017-05-01

    We have used the scanning Kelvin probe microscopy technique to monitor the charging process of highly resistive granular thin films. The sample is connected to two leads and is separated by an insulator layer from a gate electrode. When a gate voltage is applied, charges enter from the leads and rearrange across the sample. We find very slow processes with characteristic charging times exponentially distributed over a wide range of values, resulting in a logarithmic relaxation to equilibrium. After the gate voltage has been switched off, the system again relaxes logarithmically slowly to the new equilibrium. The results cannot be explained with diffusion models, but most of them can be understood with a hopping percolation model, in which the localization length is shorter than the typical site separation. The technique is very promising for the study of slow phenomena in highly resistive systems and will be able to estimate the conductance of these systems when direct macroscopic measurement techniques are not sensitive enough.

  3. A new front-end for better performances of RPC in streamer mode

    CERN Document Server

    Dupieux, P

    2003-01-01

    Resistive plate chambers (RPC) operated in streamer mode will provide the trigger of the ALICE forward muon spectrometer at the future large hadron collider at CERN. In a previous study, we had demonstrated that the time resolution of RPC in streamer mode could be improved significantly using a new discrimination technique called A DUaL Threshold (ADULT). The conclusions were based on a small sample of cosmic events, hence with almost zero incident flux, collected on a very simple test bench. The ADULT method has then been implanted in a custom integrated circuit and new data have been taken during beam and irradiation tests. The principle and the advantages of ADULT are reminded. The performances of the detector equipped with the new chip are given.

  4. Rate-capability study for a four-gap phenolic RPC with a Cs-137 source

    CERN Document Server

    Lee, Kyong Sei

    2014-01-01

    We report test results of a prototype four-gap phenolic resistive plate chamber (RPC) with high-rate gamma rays irradiated from a 200-mCi 137Cs source. The detector signals of the prototype four-gap RPC were digitized at charge thresholds of 80, 130, and 170 fC by using a 32-channel front-end-electronics board, previously developed for the current double-gap RPCs in CMS. We confirmed from the test that the cosmic muons were reliably measured with efficiencies higher than 95pct up to a gamma-background rate of 5.3 kHz cm-2. We concluded from the present R and D that use of the current four-gap phenolic RPCs is advantageous to the high-η triggers in CMS in virtue of the high rate capability.

  5. Spatial distribution of low energy plasma at comet 67P from Rosetta RPC-LAP measurements

    Science.gov (United States)

    Edberg, Niklas J. T.; Eriksson, Anders I.; Odelstad, Elias; Vigren, Erik; Henri, Pierre; Lebreton, Jean-Pierre; Mandt, Kathleen; Nilsson, Hans; Carr, Chris; Cupido, Emanuele; Vallat, Claire; Altwegg, Kathrin

    2015-04-01

    We present in situ measurements of the low energy plasma environment around comet 67P from the two Langmuir probes (LAP) on the Rosetta spacecraft, which form part of the Rosetta plasma consortium (RPC). RPC-LAP has operated almost continuously as Rosetta has orbited the comet at close distance (10-30 km) at low velocity (about 1 m/s) since August 2014. Using the RPC-LAP measurements we have produced global maps of the low energy plasma in the vicinity of 67P. Initial estimates indicate that the plasma density has reached values of several 100 cm^-3 and that the electron temperature has typically been in the range 5-10 eV, when the comet was beyond 2.5 AU from the sun. Photoionisation is the dominating process for producing the plasma around the comet while charge-exchange and impact ionisation may also contribute. The plasma environment has been found to be strongly coupled to the local neutral gas density, which in turn is coupled to which area on the comet is facing the sun. The northern summer neck-area of the comet outgasses more than other areas and above this region are the highest densities observed. In the southern winter and above the two main lobes of the comet body, the plasma density is lower. The plasma density is hence not determined by the solar wind, but by the outgassing from the comet. The 12.4-hour rotation period of the comet together with the varying latitude of the slow-moving Rosetta provide strong modulation of the RPC-LAP measurements. Besides orbiting the comet, Rosetta will also perform flybys of the comet in early 2015 when Rosetta will move to distances of several hundred kilometres from the nucleus. These flybys provide a cut-through view of the near-comet plasma environment, which will possibly give some insight to the solar-wind interaction with the cometary coma.

  6. An Emergency Georeferencing Framework for GF-4 Imagery Based on GCP Prediction and Dynamic RPC Refinement

    OpenAIRE

    Pengfei Li; Kaimin Sun; Deren Li; Haigang Sui; Yong Zhang

    2017-01-01

    GaoFen-4 (GF-4) imagery has very potential in terms of emergency response due to its gazing mode. However, only poor geometric accuracy can be obtained using the rational polynomial coefficient (RPC) parameters provided, making ground control points (GCPs) necessary for emergency response. However, selecting GCPs is traditionally time-consuming, labor-intensive, and not fully reliable. This is mainly due to the facts that (1) manual GCP selection is time-consuming and cumbersome because of to...

  7. Long-term study of optimal gas purifiers for the RPC systems at LHC

    CERN Document Server

    Altuntas, E; Glushkov, I; Guida, R; Hahn, F; Haider, S; Mandelli, B; Rouwette, S

    2012-01-01

    This study investigates the impurities produced in the gas of heavily irradiated RPC chambers and the properties of possible purifiers for the closed-loop gas systems used in the LHC experiments. The goal is finding the operational conditions that will keep the RPC gas purity near the level of the fresh gas quality to ensure proper operation of the large RPC systems at high luminosity. The properties and performance of a large number of purifiers have been understood. On that basis, an optimal combination of different filters consisting of MS (MS) 5Å and 4Å, and a CuO catalyst R11 has been chosen and validated irradiating a set of RPCs at the CERN Gamma Irradiation Facility (GIF) for several years. An important feature of this new filters configuration is the increase of the cycle duration for each purifier, which results in better stability and reduced downtime of the gas systems. If needed, it permits to comfortably increase the gas flow in the detectors during the high luminosity running at LHC.

  8. Performance of ATLAS RPC Level-1 Muon trigger during the 2015 data taking

    CERN Document Server

    Corradi, Massimo; The ATLAS collaboration

    2016-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. Its input stage consists of an array of processors receiving the full granularity of data from Resistive Plate Chambers in the central area of the ATLAS detector ("Barrel"). The trigger efficiency and the level of synchronisation of its elements with the rest of ATLAS and the LHC clock are crucial figures of this system: many parameters of the constituent RPC detector and the trigger electronics have to be constantly and carefully checked to assure a correct functioning of the Level-1 selection. Notwithstanding the complexity of such a large array of integrated RPC detectors, the ATLAS Level-1 system has resumed operations successfully after the past 2 year shutdown, with levels similar to those of Run 1. We present the inclusive monitoring of the RPC+L1 system that we have developed to characterise the behaviour of the system, using reconstructed muons in events selected by...

  9. Performance of ATLAS RPC Level-1 muon trigger during the 2015 data taking

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00001854; The ATLAS collaboration

    2016-01-01

    RPCs are used in the ATLAS experiment at the LHC for muon trigger in the barrel region, which corresponds to |eta|<1.05. The status of the barrel trigger system during the 2015 data taking is presented, including measurements of the RPC detector efficiencies and of the trigger performance. The RPC system has been active in more than 99.9% of the ATLAS data taking, showing very good reliability. The RPC detector efficiencies were close to Run-1 and to design value. The trigger efficiency for the high-pT thresholds used in single-muon triggers has been approximately 4% lower than in Run 1, mostly because of chambers disconnected from HV due to gas leaks. Two minor upgrades have been performed in preparation of Run 2 by adding the so-called feet and elevator chambers to increase the system acceptance. The feet chambers have been commissioned during 2015 and are included in the trigger since the last 2015 runs. Part of the elevator chambers are still in commissioning phase and will probably need a replacement ...

  10. Efecto de la hormona de crecimiento (GH en el catch-up de ratas con retardo prenatal de crecimiento (RPC

    Directory of Open Access Journals (Sweden)

    Quintero, Fabián

    2005-01-01

    Full Text Available El presente trabajo analiza los cambios morfométricos en el crecimiento postnatal de ratas RPC tratadas con GH. Ratas Wistar se dividieron en: Control (C, Sham-operado (Sh, RPC y RPC+GH. El RPC fue inducido por ligamiento de las arterias uterinas a los 14 días de gestación. La GH fue administrada desde los 21 hasta los 60 días de edad (Genotropin® 3.0 mg/kg/día. A los animales Sh se les inyectó sólo el diluyente. Los animales se radiografiaron a los 84 días de edad y se relevaron longitudes, anchos y alturas neurocraneana y esplacnocraneana y longitudes y anchos femoral, humeral y tibial, longitud de la columna y anchos pélvico inferior, medio y superior. Los datos fueron procesados mediante análisis de componentes principales (ACP y discriminante (AD. El primer componente del ACP mostró efecto tamaño y el segundo forma, separando los sexos y los tratamientos. Los valores de F del AD fueron altamente significativos. La primera función quedó definida por los anchos pélvico medio y superior y la longitud tibial, explicando el 66% de la varianza. La segunda por el ancho pélvico superior y longitud tibial, explicando un 18% más de la variación total. La longitud tibial discriminó entre sexos y el ancho pélvico superior entre tratamientos. El análisis separó a los RPC de los RPC+GH y agrupó a éstos últimos con los Sh. Se concluye que el tratamiento con GH en animales RPC permite el catch up en tamaño y forma corporal, siendo más efectivo en las hembras.

  11. Performances of the ATLAS RPC Level-1 Muon trigger during the Run-II data taking

    CERN Document Server

    Alberghi, Gian Luigi; The ATLAS collaboration

    2018-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. Its input stage consists of an array of processors receiving the full granularity of data from Resistive Plate Chambers in the central area of the ATLAS detector ("Barrel"). The RPCs, placed in the barrel region of the ATLAS detector, are arranged in three concentric double layers and operate in a strong magnetic toroidal field. RPC detectors cover the pseudo-rapidity range |η|<1.05 for a total surface of more than 4000 m2 and about 3600 gas volumes. The Level-1 Muon Trigger in the barrel region allows to select muon candidates with respect to their transverse momentum and associates them with the correct bunch-crossing number. The trigger system is able to take a decision within a latency of about 2 μs. We illustrate the selections, strategy and validation for an unbiased determination of the efficiency and timing of the RPC and the L1 from data; and show the results w...

  12. Characterization of RPC operation with new environmental friendly mixtures for LHC application and beyond

    Science.gov (United States)

    Guida, R.; Capeans, M.; Mandelli, B.

    2016-07-01

    The large muon trigger systems based on Resistive Plate Chambers (RPC) at the LHC experiments are currently operated with R134a based mixture. Unfortunately R134a is considered a greenhouse gas with high impact on the enviroment and therefore will be subject to regulations aiming in strongly reducing the available quantity on the market. The immediat effects might be instability on the price and incertitude in the product availability. Alternative gases (HFO-1234yf and HFO-1234ze) have been already identified by industry for specific applications as replacement of R134a. Moreover, HFCs similar to the R134a but with lower global warming potential (GWP) are already available (HFC-245fa, HFC-32, HFC-152a). The present contribution describes the results obtained with RPCs operated with new enviromemtal friendly gases. A particular attention has been addressed to the possibility of maintening the current operation conditions (i.e. currently used applied voltage and front-end electronics) in order to be able to use a new mixture for RPC systems even where the common infrastructure (i.e. high voltage and detector components) cannot be replaced for operation at higher applied voltages.

  13. Positional accuracy in RPC point determination based on high-resolution imagery

    Science.gov (United States)

    Meng, Han; Liu, Yongliang; Zhang, Jingxiong; Gong, Hao

    2007-06-01

    The rational function model (RFM), also known as rational polynomial coefficients (RPCs) or rational polynomial camera (RPC) model, is a generalized sensor model. Different from rigorous sensor model, RFM does not need to obtain the interior and exterior orientation geometry and other physical properties associated with the physical sensor. RFMs were first adopted by Space Imaging company as a replacement for rigorous sensor models, and it drew much attention from the commercial satellite data vendors who rapidly followed the suit in order to protect the confidential information of the sensors. This paper focuses on the solution for rational polynomial coefficients, RFM-based stereo-model reconstitution, and positional accuracy analysis. As RPCs do not have obvious physical meanings and their solution is iterative, analytical approaches to accuracy analysis may not be feasible; computer simulation is thus adopted to quantify accuracy in RPC-determined positional data. The simulation-based strategy is efficient in mapping local features in positional errors, which contain both the systematic and random components.

  14. Radiation Tests of Real-Sized Prototype RPCs for the Future CMS RPC Upscope

    CERN Document Server

    Lee, K.S.; Choi, S.Y.; Hong, B.; Go, Y.; Kang, M.H.; Lim, J.H.; Park, S.K.; Cimmino, A.; Crucy, S.; Fagot, A.; Gul, M.; Rios, A.A.O.; Tytgat, M.; Zaganidis, N.; Aly, S.; Assran, Y.; Radi, A.; Sayed, A.; Singh, G.; Abbrescia, M.; Iaselli, G.; Maggi, M.; Pugliese, G.; Verwilligen, P.; Doninck, W.van; Colafranceschi, S.; Sharma, A.; Benussi, L.; Bianco, S.; Piccolo, D.; Primavera, F.; Bhatnagar, V.; Kumarl, R.; Metha, A.; Singh, J.; Ahmad, A.; Ahmad, M.; Ahmed, W.; Asghar, M.I.; Awan, I.M.; Hassan, Q.; Hoorani, H.; Khan, W.A.; Khurshid, T.; Muhammad, S.; Shah, M.A.; Shahzad, H.; Kim, M.S.; Goutzvitz, M.; Grenier, G.; Lagarde, F.; Laktineh, I.B.; Carpinteyro Bernardino, S.; Uribe Estrada, C.; Pedraza, I.; Severiano, C.B.; Carrillo Moreno, S.; Vazquez Valencia, F.; Pant, L.M.; Buontempo, S.; Cavallo, N.; Esposito, M.; Fabozzi, F.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Orso, I.; Paolucci, P.; Thyssen, F.; Braghieri, A.; Magnani, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Ban, Y.; Qian, S.J.; Choi, M.; Choi, Y.; Goh, J.; Kim, D.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Lomidze, D.; Avila, C.; Cabrera, A.; Sanabria, J.C.; Crotty, I.; Vaitkus, J.

    2016-08-10

    We report on a systematic study of double-gap and four-gap phenolic resistive plate chambers (RPCs) for future high-{\\eta} RPC triggers in the CMS. In the present study, we constructed real-sized double-gap and four-gap RPCs with gap thicknesses of 1.6 and 0.8 mm, respectively, with 2-mm-thick phenolic high-pressure-laminated (HPL) plates. We examined the prototype RPCs for cosmic rays and 100 GeV muons provided by the SPS H4 beam line at CERN. We applied maximum gamma rates of 1.5 kHz cm-2 provided by 137Cs sources at Korea University and the GIF++ irradiation facility installed at the SPS H4 beam line to examine the rate capabilities of the prototype RPCs. In contrast to the case of the four-gap RPCs, we found the relatively high threshold was conducive to effectively suppressing the rapid increase of strip cluster sizes of muon hits with high voltage, especially when measuring the narrow-pitch strips. The gamma-induced currents drawn in the four-gap RPC were about one-fourth of those drawn in the double-ga...

  15. Ageing tests on the low-resistivity RPC for the ALICE dimuon arm

    CERN Document Server

    Arnaldi, R; Barret, V; Bastid, N; Blanchard, G; Chiavassa, E; Cortese, P; Crochet, Philippe; De Marco, N; Dellacasa, G; Drancourt, C; Dupieux, P; Espagnon, B; Ferretti, A; Forestier, B

    2003-01-01

    The trigger for the Dimuon Forward Spectrometer of the forthcoming ALICE experiment at CERN LHC will be provided by low-resistivity, single gap Resistive Plate Chambers working in streamer mode. Different ageing test were performed to measure and improve the life- time of the detector. Dummy chambers have been built to understand the effects of continuous gas flow upon the Bakelite resistivity: the results concerning our standard gas mixture (49% Ar, 40% forane, 7% isobutane and 4% SF//6) are reported, and compared with the same mixture in which similar to 1% of water vapor is added. Moreover, two ageing test of 1 month each have been carried out at the Gamma Irradiation Facility at CERN during 2001. The efficiency for cosmic rays under gamma irradiation of RPCs coated with different thicknesses of linseed oil was measured. After protracted operation, the detectors have shown an increase of the current and of the background rate. The increase is slower in the chamber with a thicker oil coating.

  16. First results from an aging test of a prototype RPC for the LHCb Muon System

    CERN Document Server

    Bizzeti, A; Collazuol, G; De Capua, S; Dominici, Daniele; Ganis, G; Messi, R; Passaleva, G; Santovetti, E; Veltri, M; Bizzeti, Andrea; Carboni, Giovanni; Collazuol, Gianmaria; Capua, Stefano De; Domenici, Danilo; Ganis, Gerardo; Messi, Roberto; Passaleva, Giovanni; Santovetti, Emanuele; Veltri, Michele

    2003-01-01

    Recent results of an aging test performed at the CERN Gamma Irradiation Facility on a single--gap RPC prototype developed for the LHCb Muon System are presented. The results are based on an accumulated charge of about 0.45 C/cm$^2$, corresponding to about 4 years of LHCb running at the highest background rate. The performance of the chamber has been studied under several photon flux values exploiting a muon beam. A degradation of the rate capability above 1 kHz/cm$^2$ is observed, which can be correlated to a sizeable increase of resistivity of the chamber plates. An increase of the chamber dark current is also observed. The chamber performance is found to fulfill the LHCb operation requirements.

  17. First installation of DT and RPC packages into the CMS iron yoke

    CERN Multimedia

    Jesus Puerta-Pelayo

    2004-01-01

    These pictures illustrate the installation process of muon barrel packages (DT + RPC) into the pockets of the CMS iron yoke at SX5. The chambers are first transported in groups of four from the ISR area (where they are certified and coupled together) to the construction hall in Cessy (neighbouring France), called Point 5 (or SX5). Once there, they pass through a fast high voltage and electronic certification test, before being slid into the insertion cradle. This cradle is attached to the yoke and aligned to the chamber rails, allowing an easy insertion. A rate of 3 chambers per day can be achieved. This set of pictures was taken during the first final insertion round at Point 5, where most chambers for the lower part of YB+2 were installed.

  18. CMS/RPC background particle simulation with the GEANT code preliminary results

    CERN Document Server

    Jamil, M

    2005-01-01

    A method to simulate the background particles of compact muon solenoid (CMS) endcap resistive plate chambers (RPCs) is described using a realistic Monte Carlo simulation based on the geometry and tracking (GEANT) code and analyzed with physics analysis workstation (PAW) interfaces. Sensitivity calculations were performed for particles such as gamma 's, e/sup -/'s and e/sup +/'s in the range 0.1 - 100 MeV for their respective spectra. For the evaluation of the response of detector in the Large Hadron Collider (LHC) background environment, the gamma , e/sup -/ and e/sup +/ energy spectra expected in the CMS muon endcap region were taken into account whereas the RPC sensitivity was evaluated as a function of the detector size.

  19. Study of the CMS RPC detector performance in high radiation background conditions

    CERN Document Server

    Miguel Colin, Osvaldo

    2017-01-01

    The RPC system at the CMS Detector is operating successfully from beginning of the data taking. The high instantaneous luminosity causes an extremely high flux of ionizing particles. The long period of operation (Run1 and Run2) in a huge radiation background conditions, gives the opportunity to study the operation capability of the RPCs and also to predict a data-driven extrapolation about the expecting particle rates at HL LHC (High Luminosity) scenario. The obtained results in terms of measured rate, currents and integrated charged will be presented in the poster. When it is possible they will be compared to the relevant results obtained from the dedicated study where a set of test chambers have been irradiated at GIF++ laboratory setup.

  20. Completion of installation of DT and RPC chambers before Cosmic Challenge

    CERN Multimedia

    Mimmo Dattola

    2006-01-01

    All the drift tube ("DT") and resistive plate chambers ("RPC") packages foreseen to be installed in the central barrel ring ("YB0") before the magnet test have been installed (some are missing in the photograph but have since been installed). These silver-coloured rectangular boxes in the gaps between the steel of the rings (red in the image) detect muons. Chambers for Sectors 4 and 5 (sector 1 is at the 9 o'clock position and the counting is clockwise) as well as a couple of chambers in the support "feet" (sectors 9 and 11) will be installed after the magnet test. Chambers for sectors 1 and 7 will be installed in the underground cavern ("UXC") - the latter will be in the places used for the lifting and lowering of the ring.

  1. Development of conductive coated polyester film as RPC electrodes using screen printing

    Energy Technology Data Exchange (ETDEWEB)

    Kalmani, S.D. [Tata Institute of Fundamental Research, DHEP, Homi Bhabha Road, Colaba, Mumbai 400005 (India)], E-mail: kalmani@tifr.res.in; Mondal, N.K.; Satyanarayana, B.; Verma, P. [Tata Institute of Fundamental Research, DHEP, Homi Bhabha Road, Colaba, Mumbai 400005 (India); Datar, V.M. [Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2009-05-01

    Each of the three 16 kton ICAL detector modules at the India-based Neutrino Observatory (INO) will use RPCs as the active element, sandwiched between 6 cm thick soft iron plates, for measurements on atmospheric neutrinos. The electrodes of the RPC are float glass sheets having a volume resistivity of about 10{sup 12}-10{sup 13} {omega} cm (at room temperature) covered with carbon/graphite or a conductive paint with a surface resistivity of {approx}800 k{omega}/square to 1 M{omega}/square to apply high voltage on the glass surface, so that this surface does not shield the discharge signal from the external pickup plates and is small compared to the resistivity of the glass to provide a uniform potential across the entire surface. We initially coated the surface with locally available graphite powder, mixed with lacquer and thinner, and were able to get a few hundred k{omega}/square resistivity. However, we observed a drastic reduction in surface resistivity with time and it came unstuck from the glass. Subsequently a conductive paint developed by Kansai-Nerolac was used. This paint uses modified acrylic resin as binder, conductive black pigment and solvents, which include aromatic hydrocarbons and alcohols. At room temperature, the surface dries in 10 minutes, while complete drying takes {approx}18 hours. The spraying is done at a pressure of 4 kg/cm{sup 2} with the glass plate kept at a distance of 8-10 in. Using this paint, we are able to achieve the required resistance of {approx} few hundred k{omega}/square. We still need to study the long term stability and best curing method. We need to automate the procedure to get a uniform coat and to coat a large number of glasses for the final detector. While robotic systems are available abroad costing about 5 000 000 rupees, we are exploring other alternatives. In particular, we are in the process of developing a polyester film, with a conductive coating on one side, which can be glued on to the glass. The coating was

  2. Development of conductive coated polyester film as RPC electrodes using screen printing

    Science.gov (United States)

    Kalmani, S. D.; Mondal, N. K.; Satyanarayana, B.; Verma, P.; Datar, V. M.

    2009-05-01

    Each of the three 16 kton ICAL detector modules at the India-based Neutrino Observatory (INO) will use RPCs as the active element, sandwiched between 6 cm thick soft iron plates, for measurements on atmospheric neutrinos. The electrodes of the RPC are float glass sheets having a volume resistivity of about 10 12-10 13 Ω cm (at room temperature) covered with carbon/graphite or a conductive paint with a surface resistivity of ˜800 kΩ/square to 1 MΩ/square to apply high voltage on the glass surface, so that this surface does not shield the discharge signal from the external pickup plates and is small compared to the resistivity of the glass to provide a uniform potential across the entire surface. We initially coated the surface with locally available graphite powder, mixed with lacquer and thinner, and were able to get a few hundred kΩ/square resistivity. However, we observed a drastic reduction in surface resistivity with time and it came unstuck from the glass. Subsequently a conductive paint developed by Kansai-Nerolac was used. This paint uses modified acrylic resin as binder, conductive black pigment and solvents, which include aromatic hydrocarbons and alcohols. At room temperature, the surface dries in 10 minutes, while complete drying takes ˜18 hours. The spraying is done at a pressure of 4 kg/cm 2 with the glass plate kept at a distance of 8-10 in. Using this paint, we are able to achieve the required resistance of ˜ few hundred kΩ/square. We still need to study the long term stability and best curing method. We need to automate the procedure to get a uniform coat and to coat a large number of glasses for the final detector. While robotic systems are available abroad costing about 5 000 000 rupees, we are exploring other alternatives. In particular, we are in the process of developing a polyester film, with a conductive coating on one side, which can be glued on to the glass. The coating was done using on a local commercial screen printing machine

  3. Biochemical basis of the high resistance to oxidative stress in ...

    Indian Academy of Sciences (India)

    Unknown

    the fact that D. discoideum is unusually resistant to oxi- dative stress. To address the biochemical events associated with high resistance to oxidative stress, in D. discoideum, the acti- vity of catalase, SOD and GSH-Px antioxidant enzymes were measured. SOD activity did not show any change in cells subjected to oxidative, ...

  4. Validation of OMI NO2 Data to Enhance EPA Ground Network Data: An RPC Experiment

    Science.gov (United States)

    Kleb, M. M.; Pippin, M. R.; Parker, P. A.; Rhew, R. D.; Szykman, J. J.; Neil, D. O.

    2007-12-01

    We present an RPC validation study to determine the potential use of OMI tropospheric NO2 column data to enhance spatial surface predictions of NO2 as an augmentation to the continuous NO2 ground network data collected by the State and Local Air Monitoring Stations (SLAMS) and National Air Monitoring Stations (NAMS) for the continental United States. Using one year of OMI and SLAMS/NAMS ground based data from the EPA's Air Quality System (AQS), NO2 values are compared using a variety of statistical techniques including a time series analysis at each EPA ground station in the continental United States, a site-by- site correlation analysis, site-by-site comparison of mean and standard deviation values, and regional (defined by the ten EPA regions) spatial statistics. In addition, a multivariate statistical prediction model with significance testing is developed to determine within a 95% confidence level the impact of concentration, latitude, region, season, environment (urban vs. rural), and pixel size on the correlation of OMI to EPA NO2 data. The robustness of the statistical model is evaluated using statistical methods. Results of this experiment quantify the ability to use OMI-derived NO2 observations to provide predicted surface concentrations to augment the coverage of the existing NO2 ground networks in regions of sparse or non-existent ground monitors. This predictive capability could facilitate a more capable and integrated observing network for NO2 and lead to more informed air quality management decisions at the local, state, and national level.

  5. RPC communication layer and introduction to data protection for embedded PC based control and data acquisition module

    Science.gov (United States)

    Kwiatkowski, Maciej; Roszkowski, Piotr; Zabolotny, Wojciech M.; Pozniak, Krzysztof; Romaniuk, Ryszard

    2005-09-01

    This paper describes an implementation of the communication layer based on remote procedure calling ONC RPC and presents the first prototype of hardware data protection module for control and data acquisition module being developed by the ELHEP Group for the DESY research center in Hamburg. This control and DAQ module is designed for the SIMCON module (SIMulator and CONtroller) aimed to steer the nine-cell super conducting niobium resonators built and produced for TESLA and X-FEL projects. Solutions described here will allow to establish safe connections from any place in the world and control physics experiments via Internet network.

  6. Characterization of active CMOS pixel sensors on high resistive substrate

    Energy Technology Data Exchange (ETDEWEB)

    Hirono, Toko; Hemperek, Tomasz; Huegging, Fabian; Krueger, Hans; Rymaszewski, Piotr; Wermes, Norbert [Physikalisches Institut, Universitaet Bonn, Bonn (Germany)

    2016-07-01

    Active CMOS pixel sensors are very attractive as radiation imaging pixel detector because they do not need cost-intensive fine pitch bump bonding. High radiation tolerance and time resolution are required to apply those sensors to upcoming particle physics experiments. To achieve these requirements, the active CMOS pixel sensors were developed on high resistive substrates. Signal charges are collected faster by drift in high resistive substrates than in standard low resistive substrates yielding also a higher radiation tolerance. A prototype of the active CMOS pixel sensor has been fabricated in the LFoundry 150 nm CMOS process on 2 kΩcm substrate. This prototype chip was thinned down to 300 μm and the backside has been processed and can contacted by an aluminum contact. The breakdown voltage is around -115 V, and the depletion width has been measured to be as large as 180 μm at a bias voltage of -110 V. Gain and noise of the readout circuitry agree with the designed values. Performance tests in the lab and test beam have been done before and after irradiation with X-rays and neutrons. In this presentation, the measurement results of the active CMOS prototype sensors are shown.

  7. Particle detectors made of high-resistivity Czochralski silicon

    CERN Document Server

    Härkönen, J; Ivanov, A; Li, Z; Luukka, Panja; Pirojenko, A; Riihimaki, I; Tuominen, E; Tuovinen, E; Verbitskaya, E; Virtanen, A

    2005-01-01

    We have processed pin-diodes and strip detectors on n- and p-type high-resistivity silicon wafers grown by magnetic Czochralski method. The Czochralski silicon (Cz-Si) wafers manufactured by Okmetic Oyj have nominal resistivity of 900 Omega cm and 1.9 kOmega cm for n- and p-type, respectively. The oxygen concentration in these substrates is slightly less than typically in wafers used for integrated circuit fabrication. This is optimal for semiconductor fabrication as well as for radiation hardness. The radiation hardness of devices has been investigated with several irradiation campaigns including low- and high-energy protons, neutrons, gamma-rays, lithium ions and electrons. Cz-Si was found to be more radiation hard than standard Float Zone silicon (Fz-Si) or oxygenated Fz-Si. When irradiated with protons, the full depletion voltage in Cz-Si has not exceeded its initial value of 300 V even after the fluence of 5 multiplied by 10**1**4 cm**-**2 1-MeV eq. n cm **-**2 that equals more than 30 years operation of...

  8. Potentials' distribution in high resistivity soil around extended grounding electrodes

    Directory of Open Access Journals (Sweden)

    Ivonin V. V.

    2016-12-01

    Full Text Available The potential distribution in high resistivity soil around extended grounding electrodes has been described in the paper. The high-voltage polygon has been developed for experimental investigation. It is well known that direct or indirect lightning discharges could produce dangerous conditions for human body, as well as unwanted electromagnetic interferences among electrical and electronic systems. Therefore the electromagnetic characterization of earth electrodes under high pulse transient currents is an important highpoint in the design of a grounding system. The Marx generator was developed to generate impulse similar to lightning impulse. The potentials have been measured by the probe measurement system previously developed. Grounding resistance is the main characteristic of the grounding systems. From the literature analysis and experimental data it has been shown that steady state grounding resistance can differ from impulse grounding resistance. This phenomenon is caused by the ionization process and sparking occurring in the surrounding soil. Channel spark resistance is much less soil resistivity, therefore the soil resistivity and grounding resistance decrease. Calculations of potentials in the soil have been carried out using the finite element method. The experimental data have been compared with the results of the potential distribution calculation. It has been shown that the resulting spark channels in soils significantly affect the potential distribution. Accordingly, the sparking channels are to be considered while calculating the step voltage.

  9. Design aspects and prototype test of a very precise TDC system implemented for the multigap RPC of the ALICE-TOP

    CERN Document Server

    Akindinov, A; Anselmo, F; Antonioli, P; Basile, M; Cara Romeo, G; Cifarelli, Luisa; Cindolo, F; Cosenza, F; D'Antone, I; De Caro, A; De Pasquale, S; Di Bartolomeo, A; Fusco-Girard, M; Golovine, V; Guerzoni, M; Guida, M; Hatzifotiadou, D; Kaidalov, A B; Kim, D H; Kisselev, S M; Laurenti, G; Lioublev, E; Lee, K; Lee, S C; Luvisetto, M L; Margotti, A; Martemyanov, A N; Massera, F; Meneghini, S; Michinelli, R; Nania, R; Otiougova, P; Pancaldi, G; Pesci, A; Pilastrini, R; Pinazza, O; Polozov, P A; Rizzi, M; Scapparone, E; Scioli, G; Sellitto, S B; Semeria, F; Smirnitsky, A V; Tchoumakov, M M; Ugolini, E; Usenko, E; Valenti, G; Voloshin, K G; Williams, M C S; Zagreev, B V; Zampolli, C; Zichichi, A; Zucchini, M; Zuffa, M

    2004-01-01

    The ALICE Time-of-Flight system will be a large area (150m**2) detector made by Multigap RPC (MRPC). T he time digitisation is based on the High Performance TDC chip (HPTDC). Tests carried out on board prototypes are discussed, emphasising the optimisation of the effective time resolution of the chip when working in its Very High Resolution Mode. Lab bench tests and test beam results show that a 20 ps resolution has been achieved.

  10. Evolution of the ion environment of comet 67P during the Rosetta mission as seen by RPC-ICA

    Science.gov (United States)

    Nilsson, Hans; Wieser, Gabriella Stenberg; Behar, Etienne; Gunell, Herbert; Wieser, Martin; Galand, Marina; Simon Wedlund, Cyril; Alho, Markku; Goetz, Charlotte; Yamauchi, Masatoshi; Henri, Pierre; Odelstad, Elias; Vigren, Erik

    2017-07-01

    Rosetta has followed comet 67P from low activity at more than 3.6 au heliocentric distance to high activity at perihelion (1.24 au) and then out again. We provide a general overview of the evolution of the dynamic ion environment using data from the RPC-ICA ion spectrometer. We discuss where Rosetta was located within the evolving comet magnetosphere. For the initial observations, the solar wind permeated all of the coma. In 2015 mid-April, the solar wind started to disappear from the observation region, to re-appear again in 2015 December. Low-energy cometary ions were seen at first when Rosetta was about 100 km from the nucleus at 3.6 au, and soon after consistently throughout the mission except during the excursions to farther distances from the comet. The observed flux of low-energy ions was relatively constant due to Rosetta's orbit changing with comet activity. Accelerated cometary ions, moving mainly in the antisunward direction gradually became more common as comet activity increased. These accelerated cometary ions kept being observed also after the solar wind disappeared from the location of Rosetta, with somewhat higher fluxes further away from the nucleus. Around perihelion, when Rosetta was relatively deep within the comet magnetosphere, the fluxes of accelerated cometary ions decreased, as did their maximum energy. The disappearance of more energetic cometary ions at close distance during high activity is suggested to be due to a flow pattern where these ions flow around the obstacle of the denser coma or due to charge exchange losses.

  11. Nosocomial transmission of highly resistant microorganisms on a spinal cord rehabilitation ward

    NARCIS (Netherlands)

    Slim, Erik; Smit, Christof A.; Bos, Arthur J.; Peerbooms, Paul G.

    2009-01-01

    BACKGROUND/OBJECTIVE: To study the mechanism of nosocomial transmission of highly resistant microorganisms (HRMOs). DESIGN: A prospective observational study. SETTING: A spinal cord ward of a rehabilitation center. PARTICIPANTS: Patients admitted to the spinal cord rehabilitation ward. OUTCOME

  12. MUON DETECTORS: RPC

    CERN Multimedia

    Giuseppe Iaselli

    Major interventions have been completed on the plus-side endcap. Two faulty chambers have been replaced, the gas circuit for six sectors has been modified from serial to parallel, the leaking cooling circuits have been fixed, and a few high voltage connectors have been replaced. The minus-side endcap has been fully commissioned and the link board electronics put into operation. A preliminary attempt to synchronize the minus endcap has also been attempted during the global run data taking. Some additional improvement of the grounding connections has been done on the W+2/W-2 barrel wheels. A preliminary observation of the monitoring data shows this has had a positive effect on the noise level. Significant improvement in our understanding of the CCR ring instabilities has been achieved. Additional filters will be installed on the cables to protect against noise pick-up. The implementation of the TTU technical trigger was completed and the system was debugged. The TTU now has to be integrated into the overal...

  13. Arsenic-doped high-resistivity-silicon epitaxial layers for integrating low-capacitance diodes

    NARCIS (Netherlands)

    Sakic, A.; Scholtes, T.L.M.; De Boer, W.B.; Golshani, N.; Derakhshandeh, J.; Nanver, L.K.

    2011-01-01

    An arsenic doping technique for depositing up to 40-?m-thick high-resistivity layers is presented for fabricating diodes with low RC constants that can be integrated in closely-packed configurations. The doping of the as-grown epi-layers is controlled down to 5 × 1011 cm?3, a value that is solely

  14. High-resistivity nanogranular Co–Al–O films for high-frequency applications

    NARCIS (Netherlands)

    Khalili Amiri, P.; Zhuang, Y.; Schellevis, H.; Rejaei, B.; Vroubel, M.; Ma, Y.; Burghartz, J.N.

    2007-01-01

    This work presents a series of high-resistivity nanogranular Co–Al–O films with maximum resistivity of ? 110?m??cm. The films were deposited using pulsed dc reactive sputtering of a Co72Al28 target in an oxygen/argon ambient. The samples were characterized by scanning electron microscopy (SEM), M-H

  15. Measurement of cosmic muon angular distribution and vertical integrated flux by 2 m × 2 m RPC stack at IICHEP-Madurai

    Science.gov (United States)

    Pethuraj, S.; Datar, V. M.; Majumder, G.; Mondal, N. K.; Ravindran, K. C.; Satyanarayana, B.

    2017-09-01

    The 50 kton INO-ICAL is a proposed underground high energy physics experiment at Theni, India (9o57'N, 77o16'E) to study the neutrino oscillation parameters using atmospheric neutrinos. The Resistive Plate Chamber (RPC) has been chosen as the active detector element for the ICAL detector. An experimental setup consisting of 12 layers of glass RPCs of size 2 m × 2 m has been built at IICHEP, Madurai to study the long term stability and performance of RPCs which are produced on a large scale in Indian industry. In this paper, the studies on the performance of RPCs are presented along with the angular distribution of muons at Madurai (9o56'N,78o00'E and Altitude ≈ 160 m from sea level).

  16. CMOS sensors in 90 nm fabricated on high resistivity wafers: Design concept and irradiation results

    CERN Document Server

    Rivetti, A; Wyss, J; Bisello, D; Costa, M; Kloukinas, K; Demaria, N; Pantano, D; Rousset, J; Battaglia, M; Mansuy, C; Potenza, A; Ikemoto, Y; Giubilato, P; Chalmet, P; Mugnier, H; Silvestrin, L; Marchioro, A

    2013-01-01

    The LePix project aims at improving the radiation hardness and the readout speed of monolithic CMOS sensors through the use of standard CMOS technologies fabricated on high resistivity substrates. In this context, high resistivity means beyond 400 Omega cm, which is at least one order of magnitude greater than the typical value (1-10 Omega cm) adopted for integrated circuit production. The possibility of employing these lightly doped substrates was offered by one foundry for an otherwise standard 90 nm CMOS process. In the paper, the case for such a development is first discussed. The sensor design is then described, along with the key challenges encountered in fabricating the detecting element in a very deep submicron process. Finally, irradiation results obtained on test matrices are reported. (C) 2013 Elsevier B.V. All rights reserved

  17. High resistive ferrite films by a solution process for electromagnetic compatible (EMC) devices

    Energy Technology Data Exchange (ETDEWEB)

    Subramani, A.K. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama 226-8503 (Japan); Kondo, K. [NEC Tokin Corporation, 6-7-1 Koriyama, Taihaku-ku, Sendai, Miyagi 982-8510 (Japan); Tada, M.; Abe, M. [Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1 Ookayama Meguro, Tokyo 152-8552 (Japan); Yoshimura, M. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama 226-8503 (Japan); Matsushita, N. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama 226-8503 (Japan)], E-mail: matsushita@msl.titech.ac.jp

    2009-12-15

    Mn-Zn ferrite films with high resistivity and good noise suppressing ability for use as 'coupling-type noise suppressors' have been prepared by the spin-spray ferrite plating. The as-prepared films were crystalline and exhibited single-phase spinel structure. The films had an 'integrated nano-columnar' morphology that resulted in a very high resistivity. Further, by varying the chemical composition, films with varying resistivity were prepared and then heat treated at 260 deg. C for 3 min, similar to that of the reflow soldering process. The reflection and transmission coefficients, S{sub 11} and S{sub 21} parameters, on coplanar micro-strip line (50 {omega}) were measured for the as-prepared and heat-treated films in order to study the effect of heat treatment. When the resistivity was above 2x10{sup 5} {omega}/sq, S{sub 11} and S{sub 21} exhibited uniform profiles throughout the measurement frequency (50 MHz-10 GHz), which is ideal for the 'coupling-type' noise suppressor. These films retain a moderately high resistivity and hence do not show the downshift in the stopband frequency even after the heat treatment (reflow soldering process)

  18. Molecular Mapping of High Resistance to Bacterial Leaf Spot in Lettuce PI 358001-1.

    Science.gov (United States)

    Wang, Yunwen; Lu, Huangjun; Hu, Jinguo

    2016-11-01

    Lettuce (Lactuca sativa L.) is a diploid (2n = 18) with a genome size of 2,600 Mbp, and belongs to the family Compositae. Bacterial leaf spot (BLS), caused by Xanthomonas campestris pv. vitians, is a major disease of lettuce worldwide. Leaf lettuce PI 358001-1 has been characterized as an accession highly resistant to BLS and has white seed. In order to understand inheritance of the high resistance in this germplasm line, an F3 population consisting of 163 families was developed from the cross PI 358001-1 × 'Tall Guzmaine' (a susceptible Romaine lettuce variety with black seed). The segregation ratio of reaction to disease by seedling inoculation with X. campestris pv. vitians L7 strain in the F3 families was shown to be 32:82:48 homozygous resistant/heterozygous/homozygous susceptible, fitting to 1:2:1 (n = 162, χ2 = 3.19, P = 0.20). The segregation ratio of seed color by checking F2 plants was 122:41 black/white, fitting to 3:1 (n = 163, χ2 = 0.002, P = 0.96). The results indicated that both BLS resistance and seed color were inherited as a dominant gene mode. A genetic linkage map based on 124 randomly selected F2 plants was developed to enable molecular mapping of the BLS resistance and the seed color trait. In total, 199 markers, comprising 176 amplified fragment length polymorphisms, 16 simple-sequence repeats, 5 resistant gene candidate markers, and 2 cleaved amplified polymorphic sequences (CAPS) markers were assigned to six linkage groups. The dominant resistance gene to BLS (Xcvr) was mapped on linkage group 2 and the gene locus y for seed color was identified on linkage group 5. Due to the nature of a single gene inheritance, the high-resistance gene should be readily transferred to adapted lettuce cultivars to battle against the devastating disease of lettuce.

  19. Upgrade of the Level-1 muon trigger of the ATLAS detector in the barrel-endcap transition region with RPC chambers

    CERN Document Server

    Massa, L; The ATLAS collaboration

    2014-01-01

    This report presents a project for the upgrade of the Level-1 muon trigger in the barrel-endcap transition region (1.01) caused by charged particles originating from secondary interactions downstream of the interaction point. After the LHC phase-1 upgrade, forseen for 2018, the Level-1 muon trigger rate would saturate the allocated bandwidth unless new measures are adopted to improve the rejection of fake triggers. ATLAS is going to improve the trigger selectivity in the region |$\\eta$|>1.3 with the addition of the New Small Wheel detector as an inner trigger plane. To obtain a similar trigger selectivity in the barrel-endcap transition region 1.0<|$\\eta$|<1.3, it is proposed to add new RPC chambers at the edge of the inner layer of the barrel muon spectrometer. These chambers will be based on a three layer structure with thinner gas gaps and electrodes with respect to the ATLAS standard and a new low-profile light-weight mechanical structure that will allow the installation in the limited available spa...

  20. THE EFFECT OF HIGH RESISTANCE WEIGHT TRAINING ON REPORTED PAIN IN OLDER ADULTS

    Directory of Open Access Journals (Sweden)

    Kathleen M. Knutzen

    2007-12-01

    Full Text Available The present study examined the effect of a progressive, whole- body, high resistance training program on reported pain in older adults. Ninety-eight participants (60 - 83 years completed the McGill Pain Questionnaire prior to and after an eight week training period. Seventy-nine of the participants completed a progressive, high resistance training program of 11 different exercises on three days a week. At the end of eight weeks, the training group achieved significant strength gains ranging from 62% -119% (p < 0.005. Pain measures for the training and control groups were compared using an analysis of covariance on post-test pain measures after an adjustment by pre-test scores. (p < 0.05. The training group reported less perceived pain than the control group in four pain measures (overall pain intensity, sensory dimension, miscellaneous pain measures, number of pain descriptors selected. There were no differences reported for the affective or evaluative dimensions of perceived pain, the number of painful areas, or the present pain. Results suggest that eight weeks of progressive, whole-body weight training has a positive impact on perception of pain in older adults

  1. Performance of a Medipix3RX spectroscopic pixel detector with a high resistivity gallium arsenide sensor.

    Science.gov (United States)

    Hamann, Elias; Koenig, Thomas; Zuber, Marcus; Cecilia, Angelica; Tyazhev, Anton; Tolbanov, Oleg; Procz, Simon; Fauler, Alex; Baumbach, Tilo; Fiederle, Michael

    2015-03-01

    High resistivity gallium arsenide is considered a suitable sensor material for spectroscopic X-ray imaging detectors. These sensors typically have thicknesses between a few hundred μm and 1 mm to ensure a high photon detection efficiency. However, for small pixel sizes down to several tens of μm, an effect called charge sharing reduces a detector's spectroscopic performance. The recently developed Medipix3RX readout chip overcomes this limitation by implementing a charge summing circuit, which allows the reconstruction of the full energy information of a photon interaction in a single pixel. In this work, we present the characterization of the first Medipix3RX detector assembly with a 500 μm thick high resistivity, chromium compensated gallium arsenide sensor. We analyze its properties and demonstrate the functionality of the charge summing mode by means of energy response functions recorded at a synchrotron. Furthermore, the imaging properties of the detector, in terms of its modulation transfer functions and signal-to-noise ratios, are investigated. After more than one decade of attempts to establish gallium arsenide as a sensor material for photon counting detectors, our results represent a breakthrough in obtaining detector-grade material. The sensor we introduce is therefore suitable for high resolution X-ray imaging applications.

  2. A method for detection and location of high resistance earth faults

    Energy Technology Data Exchange (ETDEWEB)

    Haenninen, S.; Lehtonen, M. [VTT Energy, Espoo (Finland); Antila, E. [ABB Transmit Oy (Finland)

    1998-08-01

    In the first part of this presentation, the theory of earth faults in unearthed and compensated power systems is briefly presented. The main factors affecting the high resistance fault detection are outlined and common practices for earth fault protection in present systems are summarized. The algorithms of the new method for high resistance fault detection and location are then presented. These are based on the change of neutral voltage and zero sequence currents, measured at the high voltage / medium voltage substation and also at the distribution line locations. The performance of the method is analyzed, and the possible error sources discussed. Among these are, for instance, switching actions, thunder storms and heavy snow fall. The feasibility of the method is then verified by an analysis based both on simulated data, which was derived using an EMTP-ATP simulator, and by real system data recorded during field tests at three substations. For the error source analysis, some real case data recorded during natural power system events, is also used

  3. Photoluminescence and AFM characterisation of photochemically etched highly resistive n-type silicon

    Energy Technology Data Exchange (ETDEWEB)

    Hadjersi, T.; Gabouze, N. [Unite de Developpement de la Technologie du Silicium (UDTS), 2, Bd. Frantz Fanon, B.P. 399 Alger-Gare, Alger (Algeria); Kooij, E.S. [Solid State Physics, MESA+ Research Institute, University of Twente, P.O. Box 217, 7500 AE Eschede (Netherlands); Yamamoto, N. [Communications Research Laboratory, Basic and Advanced Research, Division, 4-2-1, Nukui- kitamachi, Koganei,Tokyo, 184-8795 (Japan); Sakamaki, K.; Takai, H. [Tokyo Denki University, Department of Electrical Engineering, 2-2 Kanda-Nishiki-cyo, Chiyoda-ku, Tokyo, 101-8457 (Japan)

    2005-06-01

    A light-emitting layer has been made on highly resistive n-type silicon (6.4 k and ohm;cm) using photochemical etching in a mixture of HF with H{sub 2}O{sub 2}. The morphology of the porous films grown after exposure to a He-Ne laser (633 nm) at normal incidence was analysed by Atomic Force Microscopy (AFM). The results show that the film obtained are porous and the morphology of the porous layer obtained are shown to be similar to that obtained by the electrochemical method on highly doped silicon. Furthermore, excitation of the porous silicon layer formed on highly resistive silicon samples under He-Cd laser (325 nm) irradiation shows that the PL intensity increases with increasing etching time. The maximum PL spectrum peaked at 636 nm with a FWHM of about 0.3 eV. Finally, the quantum confinement effect has been invoked to explain the bright, visible, room temperature PL of porous silicon (PS). (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  4. Nanosecond X-ray detector based on high resistivity ZnO single crystal semiconductor

    Science.gov (United States)

    Zhao, Xiaolong; Chen, Liang; He, Yongning; Liu, Jinliang; Peng, Wenbo; Huang, Zhiyong; Qi, Xiaomeng; Pan, Zijian; Zhang, Wenting; Zhang, Zhongbing; Ouyang, Xiaoping

    2016-04-01

    The pulse radiation detectors are sorely needed in the fields of nuclear reaction monitoring, material analysis, astronomy study, spacecraft navigation, and space communication. In this work, we demonstrate a nanosecond X-ray detector based on ZnO single crystal semiconductor, which emerges as a promising compound-semiconductor radiation detection material for its high radiation tolerance and advanced large-size bulk crystal growth technique. The resistivity of the ZnO single crystal is as high as 1013 Ω cm due to the compensation of the donor defects (VO) and acceptor defects (VZn and Oi) after high temperature annealing in oxygen. The photoconductive X-ray detector was fabricated using the high resistivity ZnO single crystal. The rise time and fall time of the detector to a 10 ps pulse electron beam are 0.8 ns and 3.3 ns, respectively, indicating great potential for ultrafast X-ray detection applications.

  5. BJT-based detector on high-resistivity silicon with integrated biasing structure

    Science.gov (United States)

    Verzellesi, G.; Batignani, G.; Bettarini, S.; Boscardin, M.; Bosisio, L.; Dalla Betta, G.-F.; Giacomini, G.; Piemonte, C.

    2006-11-01

    A novel method for biasing phototransistor-based radiation detectors on high-resistivity Si is presented, that relies on the integration into the detector base of a pnp transistor acting as a current source. The proposed approach can be extended in a natural way to the biasing of npn detector arrays, allowing different detectors to be biased at the same quiescent current, by connecting all the biasing pnp transistors with a diode-connected reference transistor (integrated onto the same chip), so that they form a current-mirror circuit. Relying on two-dimensional numerical device simulations, several test structures have been designed and fabricated, including single BJT detectors and detector arrays with pnp biasing transistors connected in the current-mirror configuration. The electrical characterization of fabricated structures shows that both single detectors and detector arrays are operational and behave in good agreement with simulations, thus demonstrating the feasibility of the proposed approach.

  6. High-resistance GaN epilayers with low dislocation density via growth mode modification

    Science.gov (United States)

    Xu, Z. Y.; Xu, F. J.; Wang, J. M.; Lu, L.; Yang, Z. J.; Wang, X. Q.; Shen, B.

    2016-09-01

    High-resistance GaN with low dislocation density adopting growth mode modification has been investigated by metalorganic chemical vapor deposition. The sheet resistance of the order of 1016 Ω/sq has been achieved at room temperature by diminishing the oxygen impurity level close to the substrate with an AlN blocking layer. Attributed to this method which offers more freedom to tailor the growth mode, a three-dimensional (3D) growth process is introduced by adjusting the growth pressure and temperature at the initial stage of the GaN epitaxy to improve the crystalline quality. The large 3D GaN grains formed during this period roughen the surface, and the following coalescence of the GaN grains causes threading dislocations bending, which finally remarkably reduces the dislocation density.

  7. Investigation on some factors affecting crack formation in high resistance aluminum alloys

    Directory of Open Access Journals (Sweden)

    A. Brotzu

    2017-10-01

    Full Text Available Aluminum alloys having good mechanical properties are Al-ZnMg alloys (7xxx and Al-Cu-Li alloys (Weldalite. These alloys may be subjected to stress corrosion cracking. In order to overcome this problem the Al 7050 alloy has been developed and it is widely used for aerospace applications. Despite that, some components made of this alloy cracked during the manufacturing process including machining and chemical anodization. In a previous work cracked Al 7050 components have been analyzed in order to identify possible causes of crack formation. In this work the susceptibility of this alloy to intergranular corrosion has been analysed and compared with that of other high resistance aluminum alloys

  8. Frequency-domain analysis of intrinsic neuronal properties using high-resistant electrodes

    Directory of Open Access Journals (Sweden)

    Christian Rössert

    2009-08-01

    Full Text Available Intrinsic cellular properties of neurons in culture or slices are usually studied by the whole cell clamp method using low-resistant patch pipettes. These electrodes allow detailed analyses with standard electrophysiological methods such as current- or voltage-clamp. However, in these preparations large parts of the network and dendritic structures may be removed, thus preventing an adequate study of synaptic signal processing. Therefore, intact in vivo preparations or isolated in vitro whole brains have been used in which intracellular recordings are usually made with sharp, high-resistant electrodes to optimize the impalement of neurons. The general non-linear resistance properties of these electrodes, however, severely limit accurate quantitative studies of membrane dynamics especially needed for precise modelling. Therefore, we have developed a frequency-domain analysis of membrane properties that uses a Piece-wise Non-linear Electrode Compensation (PNEC method. The technique was tested in second-order vestibular neurons and abducens motoneurons of isolated frog whole brain preparations using sharp potassium chloride- or potassium acetate-filled electrodes. All recordings were performed without online electrode compensation. The properties of each electrode were determined separately after the neuronal recordings and were used in the frequency-domain analysis of the combined measurement of electrode and cell. This allowed detailed analysis of membrane properties in the frequency-domain with high-resistant electrodes and provided quantitative data that can be further used to model channel kinetics. Thus, sharp electrodes can be used for the characterization of intrinsic properties and synaptic inputs of neurons in intact brains.

  9. Analysis of RE4 Construction Cosmic Muon Test Data and Comparison with 2015 Collision Calibration Run Data for the Newly Installed RPC Chambers in the 4th Muon Endcap Station of the CMS Detector

    CERN Document Server

    Iqbal, Muhammad Ansar

    2015-01-01

    RPC are the heart of the muon system of CMS experiment at LHC, CERN. Recently a new endcap layer, RE4, was added to increase redundancy. These added chambers were tested during the construction period with cosmic muons in the 904 lab at Prevessin, CERN. This study analyzes the HV scan from those tests and compares them with the first 2015 collision data taken at Point-5. The analysis showed that most of the chambers were producing more than 90% efficiency and were in good agreement with the Point-5 results. Those which did not give good results were reported. Other variables like working point and maximum efficiency were also studied.

  10. Low- and High-Resistance Exercise: Long-Term Adherence and Motivation among Older Adults.

    Science.gov (United States)

    Van Roie, Evelien; Bautmans, Ivan; Coudyzer, Walter; Boen, Filip; Delecluse, Christophe

    2015-01-01

    In terms of motivation and long-term adherence, low-resistance exercise might be more suitable for older adults than high-resistance exercise. However, more data are needed to support this claim. The objective was to investigate the effect of low- and high-resistance exercise protocols on long-term adherence and motivation. This study was designed as an exploratory 24-week follow-up of a randomized 12-week resistance training intervention in older adults. Participants were free to decide whether or not they continued resistance training at their own expense following the intervention. Fifty-six older adults were randomly assigned to HIGH [2 × 10-15 repetitions at 80% of one repetition maximum (1RM)], LOW (1 × 80-100 repetitions at 20% of 1RM), or LOW+ (1 × 60 repetitions at 20% of 1RM + 1 × 10-20 repetitions at 40% 1RM). Motivation, self-efficacy and the perceived barriers for continuing resistance exercise were measured after cessation of each supervised intervention and at follow-up, while long-term adherence was probed retrospectively at follow-up. Participants reported high levels of self-determined motivation before, during, and after the supervised intervention, with no differences between groups (p > 0.05). Nevertheless, only few participants continued strength training after the intervention: 17% in HIGH, 21% in LOW+, and 11% in LOW (p > 0.05). The most commonly reported barriers for continuing resistance exercise were perceived lack of time (46%), being more interested in other physical activities (40%), seasonal reasons (40%), and financial cost (28%). The results suggest no difference in long-term adherence after the end of a supervised exercise intervention at high or low external resistances. Long-term adherence was limited despite high levels of self-determined motivation during the interventions. These findings highlight the importance of further research on developing strategies to overcome barriers of older adults to adhere to resistance

  11. Bacteremia caused by a highly-resistant Streptococcus pneumoniae serotype 19A circulating in a daycare center.

    Science.gov (United States)

    Shouval, Dror S; Porat, Nurith; Dagan, Ron; Keller, Nathan; Bilavsky, Efraim; Sivan, Yoram; Amir, Jacob

    2010-09-01

    We describe the clinical course of a previously healthy 20-month-old toddler admitted with high fever and leukocytosis. Blood culture grew Streptococcus pneumoniae serotype 19A, belonging to the ST663 clone, highly resistant to penicillin, ceftriaxone, and erythromycin. The same clone with identical antibiogram was isolated from the nasopharynx of another three of the other five healthy children attending the same daycare center as the patient. This case exemplifies the potential problems posed by highly-resistant S. pneumoniae serotype 19A, an emerging pathogen worldwide. Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  12. Experimental investigation of the reliability issue of RRAM based on high resistance state conduction.

    Science.gov (United States)

    Zhang, Lijie; Hsu, Yen-Ya; Chen, Frederick T; Lee, Heng-Yuan; Chen, Yu-Sheng; Chen, Wei-Su; Gu, Pei-Yi; Liu, Wen-Hsing; Wang, Shun-Min; Tsai, Chen-Han; Huang, Ru; Tsai, Ming-Jinn

    2011-06-24

    In this paper, reliability issues of robust HfO(x)-based RRAM are experimentally investigated in terms of cycling ageing, temperature impact and voltage acceleration. All reliability issues can be estimated by the conduction of the high resistance state (HRS). The conduction current of the HRS exponentially increases as the square root of the applied voltage, which is well explained by 'quasi-Poole-Frenkel-type' trap assistant tunneling. Further experiments on HRS conduction at different temperatures show that the depth of the potential well of the trap in HfO(x) film is about 0.31 eV. The degradation induced by the cycling ageing is possibly ascribed to the increase of the amount of oxygen ions in the TiO(x) layer of the TiN/TiO(x)/HfO(x)/TiN device. The retention times with various stress voltages at different temperatures also exhibit an exponential relationship to the square root of the applied voltage, indicating that stress current plays a dominant role for the degradation of the HRS. An oxygen-release model is proposed to explain the relationship of retention time to HRS conduction current.

  13. Arsenic-Doped High-Resistivity-Silicon Epitaxial Layers for Integrating Low-Capacitance Diodes

    Directory of Open Access Journals (Sweden)

    Jaber Derakhshandeh

    2011-12-01

    Full Text Available An arsenic doping technique for depositing up to 40-μm-thick high-resistivity layers is presented for fabricating diodes with low RC constants that can be integrated in closely-packed configurations. The doping of the as-grown epi-layers is controlled down to 5 × 1011 cm−3, a value that is solely limited by the cleanness of the epitaxial reactor chamber. To ensure such a low doping concentration, first an As-doped Si seed layer is grown with a concentration of 1016 to 1017 cm−3, after which the dopant gas arsine is turned off and a thick lightly-doped epi-layer is deposited. The final doping in the thick epi-layer relies on the segregation and incorporation of As from the seed layer, and it also depends on the final thickness of the layer, and the exact growth cycles. The obtained epi-layers exhibit a low density of stacking faults, an over-the-wafer doping uniformity of 3.6%, and a lifetime of generated carriers of more than 2.5 ms. Furthermore, the implementation of a segmented photodiode electron detector is demonstrated, featuring a 30 pF capacitance and a 90 Ω series resistance for a 7.6 mm2 anode area.

  14. Cecum of guinea pig is a reservoir and sigmoid is a high-resistance conduit.

    Science.gov (United States)

    Lange, W; Schulze-Delrieu, K; Lange, H; Shirazi, S; Lepsien, G

    1995-05-01

    We compared the filling responses of the cecum and the sigmoid of the guinea pig using volumes up to 60 ml and 2.5 ml, respectively. In the isolated cecum, each 1-cm increment of hydrostatic pressure above zero led to accommodation of 10 ml volume; in the sigmoid, the yield pressure (at which accommodation first occurred) was 6 cm H2O, and pressure increments up to 20 cm H2O produced volume increments of less than 0.5 ml. Resting pressure at half-maximal filling was 5.0 +/- 0.7 cm H2O for the sigmoid and 1.7 +/- 0.6 cm H2O for the cecum. K+ depolarization led to a significant upward shift in the pressure curves of both segments. Ca2+ withdrawal decreased sigmoid and cecal pressures at some volumes. Distension of the cecum triggered intermittent contractions, which began with the shortening of the teniae and were associated with low-amplitude pressures and expulsion of a 5- to 10-ml volume. Distension of the sigmoid produced propagating contractions that were associated with high-amplitude pressures and lengthening; compartmentalization in the sigmoid prevented efflux from it, and volume inflow was not affected by pressure waves. Our observations indicate that its large capacity and great distensibility make the cecum suitable for reservoir functions, whereas its narrowness and lack of distensibility make the sigmoid a high-resistance conduit.

  15. 77 GHz MEMS antennas on high-resistivity silicon for linear and circular polarization

    KAUST Repository

    Sallam, M. O.

    2011-07-01

    Two new MEMS antennas operating at 77 GHz are presented in this paper. The first antenna is linearly polarized. It possesses a vertical silicon wall that carries a dipole on top of it. The wall is located on top of silicon substrate covered with a ground plane. The other side of the substrate carries a microstrip feeding network in the form of U-turn that causes 180 phase shift. This phase-shifter feeds the arms of the dipole antenna via two vertical Through-Silicon Vias (TSVs) that go through the entire wafer. The second antenna is circularly polarized and formed using two linearly polarized antennas spatially rotated with respect to each other by 90 and excited with 90 phase shift. Both antennas are fabricated using novel process flow on a single high-resistivity silicon wafer via bulk micromachining. Only three processing steps are required to fabricate these antennas. The proposed antennas have appealing characteristics, such as high polarization purity, high gain, and high radiation efficiency. © 2011 IEEE.

  16. Experimental investigation of the reliability issue of RRAM based on high resistance state conduction

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Lijie; Huang Ru [Institute of Microelectronics, Peking University, Beijing 100871 (China); Hsu, Yen-Ya; Chen, Frederick T; Lee, Heng-Yuan; Chen Yusheng; Chen Weisu; Gu Peiyi; Liu, Wen-Hsing; Wang, Shun-Min; Tsai, Chen-Han; Tsai, Ming-Jinn, E-mail: zhanglijie@ime.pku.edu.cn [Nanoelectronic Technology Division, Electronics and Optoelectronics Research Laboratories, Industrial Technology Research Institute (ITRI), Chutung, Hsinchu 31040, Taiwan (China)

    2011-06-24

    In this paper, reliability issues of robust HfO{sub x}-based RRAM are experimentally investigated in terms of cycling ageing, temperature impact and voltage acceleration. All reliability issues can be estimated by the conduction of the high resistance state (HRS). The conduction current of the HRS exponentially increases as the square root of the applied voltage, which is well explained by 'quasi-Poole-Frenkel-type' trap assistant tunneling. Further experiments on HRS conduction at different temperatures show that the depth of the potential well of the trap in HfO{sub x} film is about 0.31 eV. The degradation induced by the cycling ageing is possibly ascribed to the increase of the amount of oxygen ions in the TiO{sub x} layer of the TiN/TiO{sub x}/HfO{sub x}/TiN device. The retention times with various stress voltages at different temperatures also exhibit an exponential relationship to the square root of the applied voltage, indicating that stress current plays a dominant role for the degradation of the HRS. An oxygen-release model is proposed to explain the relationship of retention time to HRS conduction current.

  17. Dielectric properties of highly resistive GaN crystals grown by ammonothermal method at microwave frequencies

    Directory of Open Access Journals (Sweden)

    Jerzy Krupka

    2016-03-01

    Full Text Available Permittivity, the dielectric loss tangent and conductivity of semi-insulating Gallium Nitride crystals have been measured as functions of frequency from 10 GHz to 50 GHz and temperature from 295 to 560 K employing quasi TE0np mode dielectric resonator technique. Crystals were grown using ammonothermal method. Two kinds of doping were used to obtain high resistivity crystals; one with deep acceptors in form of transition metal ions, and the other with shallow Mg acceptors. The sample compensated with transition metal ions exhibited semi-insulating behavior in the whole temperature range. The sample doped with Mg acceptors remained semi-insulating up to 390 K. At temperatures exceeding 390 K the conductivity term in the total dielectric loss tangent of Mg compensated sample becomes dominant and it increases exponentially with activation energy of 1.14 eV. It has been proved that ammonothermal method with appropriate doping allows growth of high quality, temperature stable semi-insulating GaN crystals.

  18. Diagnostic Evasion of Highly-Resistant Microorganisms: A Critical Factor in Nosocomial Outbreaks.

    Science.gov (United States)

    Zhou, Xuewei; Friedrich, Alexander W; Bathoorn, Erik

    2017-01-01

    Highly resistant microorganisms (HRMOs) may evade screening strategies used in routine diagnostics. Bacteria that have evolved to evade diagnostic tests may have a selective advantage in the nosocomial environment. Evasion of resistance detection can result from the following mechanisms: low-level expression of resistance genes not resulting in detectable resistance, slow growing variants, mimicry of wild-type-resistance, and resistance mechanisms that are only detected if induced by antibiotic pressure. We reviewed reports on hospital outbreaks in the Netherlands over the past 5 years. Remarkably, many outbreaks including major nation-wide outbreaks were caused by microorganisms able to evade resistance detection by diagnostic screening tests. We describe various examples of diagnostic evasion by several HRMOs and discuss this in a broad and international perspective. The epidemiology of hospital-associated bacteria may strongly be affected by diagnostic screening strategies. This may result in an increasing reservoir of resistance genes in hospital populations that is unnoticed. The resistance elements may horizontally transfer to hosts with systems for high-level expression, resulting in a clinically significant resistance problem. We advise to communicate the identification of HRMOs that evade diagnostics within national and regional networks. Such signaling networks may prevent inter-hospital outbreaks, and allow collaborative development of adapted diagnostic tests.

  19. Impact ionization in high resistivity silicon induced by an intense terahertz field enhanced by an antenna array

    DEFF Research Database (Denmark)

    Tarekegne, Abebe Tilahun; Iwaszczuk, Krzysztof; Zalkovskij, Maksim

    2015-01-01

    We report on the observation of ultrafast impact ionization and carrier generation in high resistivity silicon induced by intense subpicosecond terahertz transients. Local terahertz peak electric fields of several MV cm−1 are obtained by field enhancement in the near field of a resonant metallic...

  20. Multiple Species of Trichosporon Produce Biofilms Highly Resistant to Triazoles and Amphotericin B

    Science.gov (United States)

    Iturrieta-González, Isabel Antonieta; Padovan, Ana Carolina Barbosa; Bizerra, Fernando César; Hahn, Rosane Christine; Colombo, Arnaldo Lopes

    2014-01-01

    Invasive infections caused by Trichosporon spp. have increased considerably in recent years, especially in neutropenic and critically ill patients using catheters and antibiotics. The genus presents limited sensitivity to different antifungal agents, but triazoles are the first choice for treatment. Here, we investigated the biofilm production and antifungal susceptibility to triazoles and amphotericin B of 54 Trichosporon spp. isolates obtained from blood samples (19), urine (20) and superficial mycosis (15). All isolates and 7 reference strains were identified by sequence analysis and phylogenetic inferences of the IGS1 region of the rDNA. Biofilms were grown on 96-well plates and quantitation was performed using crystal violet staining, complemented with Scanning Electron Microscopy (SEM). Susceptibility tests for fluconazole, itraconazole, voriconazole and amphotericin B were processed using the microdilution broth method (CLSI) for planktonic cells and XTT reduction assay for biofilm-forming cells. Our results showed that T. asahii was the most frequent species identified (66.7%), followed by T. faecale (11.1%), T. asteroides (9.3%), T. inkin (7.4%), T. dermatis (3.7%) and one T. coremiiforme (1.8%). We identified 4 genotypes within T. asahii isolates (G1, G3, G4 and G5) and 2 genotypes within T. faecale (G1 and G3). All species exhibited high adhesion and biofilm formation capabilities, mainly T. inkin, T. asteroides and T. faecale. Microscopy images of high biofilm-producing isolates showed that T. asahii presented mainly hyphae and arthroconidia, whereas T. asteroides exhibited mainly short arthroconidia and few filaments. Voriconazole exhibited the best in vitro activity against all species tested. Biofilm-forming cells of isolates and reference strains were highly resistant to all antifungals tested. We concluded that levels of biofilm formation by Trichosporon spp. were similar or even greater than those described for the Candida genus. Biofilm

  1. Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B.

    Science.gov (United States)

    Iturrieta-González, Isabel Antonieta; Padovan, Ana Carolina Barbosa; Bizerra, Fernando César; Hahn, Rosane Christine; Colombo, Arnaldo Lopes

    2014-01-01

    Invasive infections caused by Trichosporon spp. have increased considerably in recent years, especially in neutropenic and critically ill patients using catheters and antibiotics. The genus presents limited sensitivity to different antifungal agents, but triazoles are the first choice for treatment. Here, we investigated the biofilm production and antifungal susceptibility to triazoles and amphotericin B of 54 Trichosporon spp. isolates obtained from blood samples (19), urine (20) and superficial mycosis (15). All isolates and 7 reference strains were identified by sequence analysis and phylogenetic inferences of the IGS1 region of the rDNA. Biofilms were grown on 96-well plates and quantitation was performed using crystal violet staining, complemented with Scanning Electron Microscopy (SEM). Susceptibility tests for fluconazole, itraconazole, voriconazole and amphotericin B were processed using the microdilution broth method (CLSI) for planktonic cells and XTT reduction assay for biofilm-forming cells. Our results showed that T. asahii was the most frequent species identified (66.7%), followed by T. faecale (11.1%), T. asteroides (9.3%), T. inkin (7.4%), T. dermatis (3.7%) and one T. coremiiforme (1.8%). We identified 4 genotypes within T. asahii isolates (G1, G3, G4 and G5) and 2 genotypes within T. faecale (G1 and G3). All species exhibited high adhesion and biofilm formation capabilities, mainly T. inkin, T. asteroides and T. faecale. Microscopy images of high biofilm-producing isolates showed that T. asahii presented mainly hyphae and arthroconidia, whereas T. asteroides exhibited mainly short arthroconidia and few filaments. Voriconazole exhibited the best in vitro activity against all species tested. Biofilm-forming cells of isolates and reference strains were highly resistant to all antifungals tested. We concluded that levels of biofilm formation by Trichosporon spp. were similar or even greater than those described for the Candida genus. Biofilm

  2. Transgenic cotton expressing Cry10Aa toxin confers high resistance to the cotton boll weevil.

    Science.gov (United States)

    Ribeiro, Thuanne Pires; Arraes, Fabricio Barbosa Monteiro; Lourenço-Tessutti, Isabela Tristan; Silva, Marilia Santos; Lisei-de-Sá, Maria Eugênia; Lucena, Wagner Alexandre; Macedo, Leonardo Lima Pepino; Lima, Janaina Nascimento; Santos Amorim, Regina Maria; Artico, Sinara; Alves-Ferreira, Márcio; Mattar Silva, Maria Cristina; Grossi-de-Sa, Maria Fatima

    2017-08-01

    Genetically modified (GM) cotton plants that effectively control cotton boll weevil (CBW), which is the most destructive cotton insect pest in South America, are reported here for the first time. This work presents the successful development of a new GM cotton with high resistance to CBW conferred by Cry10Aa toxin, a protein encoded by entomopathogenic Bacillus thuringiensis (Bt) gene. The plant transformation vector harbouring cry10Aa gene driven by the cotton ubiquitination-related promoter uceA1.7 was introduced into a Brazilian cotton cultivar by biolistic transformation. Quantitative PCR (qPCR) assays revealed high transcription levels of cry10Aa in both T 0 GM cotton leaf and flower bud tissues. Southern blot and qPCR-based 2 -ΔΔCt analyses revealed that T 0 GM plants had either one or two transgene copies. Quantitative and qualitative analyses of Cry10Aa protein expression showed variable protein expression levels in both flower buds and leaves tissues of T 0 GM cotton plants, ranging from approximately 3.0 to 14.0 μg g -1 fresh tissue. CBW susceptibility bioassays, performed by feeding adults and larvae with T 0 GM cotton leaves and flower buds, respectively, demonstrated a significant entomotoxic effect and a high level of CBW mortality (up to 100%). Molecular analysis revealed that transgene stability and entomotoxic effect to CBW were maintained in T 1 generation as the Cry10Aa toxin expression levels remained high in both tissues, ranging from 4.05 to 19.57 μg g -1 fresh tissue, and the CBW mortality rate remained around 100%. In conclusion, these Cry10Aa GM cotton plants represent a great advance in the control of the devastating CBW insect pest and can substantially impact cotton agribusiness. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  3. Not all instability training devices enhance muscle activation in highly resistance-trained individuals.

    Science.gov (United States)

    Wahl, Michael J; Behm, David G

    2008-07-01

    The objective of this study was to measure the electromyographic (EMG) activity of the soleus, bicep femoris, rectus femoris, lower abdominal, and lumbosacral erector spinae (LSES) muscles with a variety of (a) instability devices, (b) stable and unstable (Dyna Disc) exercises, and (c) a fatiguing exercise in 16 highly conditioned individuals. The device protocol had participants assume standing and squatting postures while balancing on a variety of unstable platforms (Dyna Disc, BOSU ball, wobble board, and a Swiss ball) and a stable floor. The exercise protocol had subjects performing, static front lunges, static side lunges, 1-leg hip extensions, 1-leg reaches, and calf raises on a floor or an unstable Dyna Disc. For the fatigue experiment, a wall sit position was undertaken under stable and unstable (BOSU ball) conditions. Results for the device experiment demonstrated increased activity for all muscles when standing on a Swiss ball and all muscles other than the rectus femoris when standing on a wobble board. Only lower abdominals and soleus EMG activity increased while squatting on a Swiss ball and wobble board. Devices such as the Dyna Disc and BOSU ball did not exhibit significant differences in muscle activation under any conditions, except the LSES in the standing Dyna Disc conditions. During the exercise protocol, there were no significant changes in muscle activity between stable and unstable (Dyna Disc) conditions. With the fatigue protocol, soleus EMG activity was 51% greater with a stable base. These results indicate that the use of moderately unstable training devices (i.e., Dyna Disc, BOSU ball) did not provide sufficient challenges to the neuromuscular system in highly resistance-trained individuals. Since highly trained individuals may already possess enhanced stability from the use of dynamic free weights, a greater degree of instability may be necessary.

  4. RPC understanding and future perspectives

    CERN Document Server

    Santonico, R

    2004-01-01

    The understanding of the long-term behavior of the RPCs developed as dedicated muon trigger detectors at LHC and presently in construction, is analyzed. The main aging mechanisms are reviewed. The gas contamination by the hydrofluoric acid is analyzed as a possible aging cause and a method for measuring the fluorine concentration in the exhaust gas is described. Finally, the use of RPCs for the detection of Cosmic Ray Extensive Air Showers and their imaging capabilities are briefly discussed.

  5. RPC operation at high temperature

    CERN Document Server

    Aielli, G; Cardarelli, R; Di Ciaccio, A; Di Stante, L; Liberti, B; Paoloni, A; Pastori, E; Santonico, R

    2003-01-01

    The resistive electrodes of RPCs utilised in several current experiments (ATLAS, CMS, ALICE, BABAR and ARGO) are made of phenolic /melaminic polymers, with room temperature resistivities ranging from 10**1**0 Omega cm, for high rate operation in avalanche mode, to 5 multiplied by 10**1**1 Omega cm, for streamer mode operation at low rate. The resistivity has however a strong temperature dependence, decreasing exponentially with increasing temperature. We have tested several RPCs with different electrode resistivities in avalanche as well as in streamer mode operation. The behaviours of the operating current and of the counting rate have been studied at different temperatures. Long-term operation has also been studied at T = 45 degree C and 35 degree C, respectively, for high and low resistivity electrodes RPCs.

  6. Hybrid ZnO/phthalocyanine photovoltaic device with highly resistive ZnO intermediate layer.

    Science.gov (United States)

    Izaki, Masanobu; Chizaki, Ryo; Saito, Takamasa; Murata, Kazufumi; Sasano, Junji; Shinagawa, Tsutomu

    2013-10-09

    We report a hybrid photovoltaic device composed of a 3.3 eV bandgap zinc oxide (ZnO) semiconductor and metal-free phthalocyanine layers and the effects of the insertion of the highly resistive ZnO buffer layer on the electrical characteristics of the rectification feature and photovoltaic performance. The hybrid photovoltaic devices have been constructed by electrodeposition of the 300 nm thick ZnO layer in a simple zinc nitrate aqueous solution followed by vacuum evaporation of 50-400 nm thick-phthalocyanine layers. The ZnO layers with the resistivity of 1.8 × 10(3) and 1 × 10(8) Ω cm were prepared by adjusting the cathodic current density and were installed into the hybrid photovoltaic devices as the n-type and buffer layer, respectively. The phthalocyanine layers with the characteristic monoclinic lattice showed a characteristic optical absorption feature regardless of the thickness, but the preferred orientation changed depending on the thickness. The ZnO buffer-free hybrid 50 nm thick phthalocyanine/n-ZnO photovoltaic device showed a rectification feature but possessed a poor photovoltaic performance with a conversion efficiency of 7.5 × 10(-7) %, open circuit voltage of 0.041 V, and short circuit current density of 8.0 × 10(-5) mA cm(-2). The insertion of the ZnO buffer layer between the n-ZnO and phthalocyanine layers induced improvements in both the rectification feature and photovoltaic performance. The excellent rectification feature with a rectification ratio of 3188 and ideally factor of 1.29 was obtained for the hybrid 200 nm thick phthalocyanine/ZnO buffer/n-ZnO photovoltaic device, and the hybrid photovoltaic device possessed an improved photovoltaic performance with the conversion efficiency of 0.0016%, open circuit voltage of 0.31 V, and short circuit current density of 0.015 mA cm(-2).

  7. SU-E-T-447: Evaluation of the Anisotropic Analytical Algorithm (AAA) Heterogeneity Correction Dose Calculation in Flattened and Flattening- Filter-Free (FFF) Beams for High Energy X-Ray Beams Using the Radiological Physics Center (RPC) Lung Phantom.

    Science.gov (United States)

    Repchak, R; Molineu, A; Popple, R; Kry, S; Howell, R; Followill, D

    2012-06-01

    Compare the accuracy of AAA heterogeneity corrected dose calculation algorithm for high energy x-ray beams (>10 MV) for flattened and FFF beams using RPC anthropomorphic thorax phantom. Six static beam SBRT treatment plans were created using the Varian Eclipse treatment planning system (TPS) AAA v.8.9.08 heterogeneity correction algorithm. Two flattened beam plans (6 MV and 18 MV) and four other plans (6 MV, 6 MV FFF, 10 MV FFF and 15 MV) were delivered using a Clinac 21EX and TrueBeam STx, respectively. Prescription dose/coverage, 6 Gy to 95% PTV, and constraints were the same for all plans. The phantom contained radiochromic films in the 3 major planes and TLDs in the heart, spine, and tumor. Point doses and 2D dose distributions were exported from the Eclipse TPS and compared with the measured doses. The gamma index analysis evaluation criteria of ±5% dose to agreement and 3 mm distance to agreement was used. TLD to TPS tumor point dose ratios were 0.971±0.006(6MV) and 0.957±0.002(6MV), 0.995±0.005(15MV), 1.114±0.006(18MV), and 0.957±0.003(6MV FFF), 0.974±0.011(10MV FFF) for the six plans. Using ±5%/3mm gamma analysis criteria, the average passing rates for all three films were 96.3% and 95.5%, 97.4%, 66.1%, 93.7%, and 96.3% for the 6 MV, 6 MV, 15 MV, 18 MV, 6 MV FFF, and 10 MV FFF plans, respectively. Dose profiles were also evaluated. The current RPC credentialing criteria are: RPC/Inst. tumor dose ratio of 0.97±0.05 and 85% of the pixels in each film plane must pass a ±5%/5mm gamma index analysis. These data demonstrate that the AAA heterogeneity correction dose calculation algorithm is accurate for photon energies in 6-15 MV range for flattened and FFF beams. Heterogeneity corrected dose calculations for photon energies >15 MV were not accurate. Work supported by grants CA10953 and CA81647 (NCI, DHHS). © 2012 American Association of Physicists in Medicine.

  8. Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea

    Directory of Open Access Journals (Sweden)

    Siebers Bettina

    2009-10-01

    Full Text Available Abstract One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes. Reviewers: This article was reviewed by Andrei Osterman and Patrick Forterre (nominated by Purificación López-García

  9. Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea.

    Science.gov (United States)

    Blombach, Fabian; Makarova, Kira S; Marrero, Jeannette; Siebers, Bettina; Koonin, Eugene V; van der Oost, John

    2009-10-14

    One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.

  10. Effect of filament twist and high resistive barrier on the properties of Ag-sheathed Bi2223 tape

    Science.gov (United States)

    Nakamura, Y.; Fujiwara, Y.; Nagaoka, A.; Machida, T.; Inada, R.; Oota, A.

    2010-11-01

    Although the introduction of filament twisting with high resistive barrier between the filaments is effective to reduce the AC loss, the Jc value of the tape was easily decreased by the filament twisting and insertion of high resistive barrier. This decrease in Jc is a problem to achieve low AC loss and high Ic tape. In this study, the effects of filament twist and high resistive barrier on the microstructure and Jc property were investigated to overcome the Jc reduction. The Bi2223 tapes with filament twist or oxide barrier were fabricated by powder-in-tube method. The Jc value of twist tape gradually decreased as decreasing the twist pitch, and the degree of Jc reduction was small in slim tape compared to wide tape. This reduction would attribute to the small actual cross sectional area of the filament perpendicular to the current direction because the filament has a tilt angle from the tape axis. On the other hand, the conversion ratio of Bi2223 became small as increasing the thickness of SZO barrier layer. Since the SZO barrier has less reactivity with 2223 filament, this suppression of the Bi2223 formation would not be caused by the formation of impurity phase but would be caused by the suppression of gas release from the filaments by oxide barrier. The conversion ratio of Bi2223 increased in the short sample where the gas could be released from the both end of the tape. These results suggest that the gas diffusion from filaments would be important for the formation of Bi2223. Hence, the use of slim tape for decreasing the tilt angle of the filament and keeping the diffusion path of gas from the filaments may improve the Jc value of twist and barrier tapes.

  11. Primary defect transformations in high-resistivity p-type silicon irradiated with electrons at cryogenic temperatures

    CERN Document Server

    Makarenko, L F; Korshunov, F P; Murin, L I; Moll, M

    2009-01-01

    It has been revealed that self-interstitials formed under low intensity electron irradiationin high resistivity p-type silicon can be retained frozen up to room temperature. Low thermal mobility of the self-interstitials suggests that Frenkelpair sinsilicon can be stable at temperatures of about or higher than 100K. A broad DLTS peak with activation energy of 0.14–0.17eV can be identified as related to Frenkel pairs. This peak anneals out at temperatures of 120 140K. Experimental evidences are presented that be coming more mobile under forwardcurrent injection the self-interstitials change their charge state to a less positive one.

  12. High resistance rate against 15 different antibiotics in aerobic gram-negative bacteria isolates of cardiology intensive care unit patients

    Directory of Open Access Journals (Sweden)

    Küçükates E

    2002-01-01

    Full Text Available Aerobic gram negative bacteria were isolated and examined microbiologically from various clinical samples of 602 patients hospitalized between January 1997 and December 2000 in surgical and coronary intensive care units (ICUs. A total of 827 isolates were obtained from 602 patients. The majority of microorganisms were isolated from the respiratory tract (50.3% and blood (39.9%. Pseudomonas spp. were the most frequently isolated gram negative species (32.7%, followed by Acinetobacter spp. (24.0% and Klebsiella pneumoniae (19.4%. High resistance rates to all antibiotics studied were observed. Imipenem and meropenem were the most effective antibiotics against gram negatives.

  13. Analysis Of The Austenite Grain Growth In Low-Alloy Boron Steel With High Resistance To Abrasive Wear

    Directory of Open Access Journals (Sweden)

    Białobrzeska B.

    2015-09-01

    Full Text Available Today low-alloy steels with boron achieve high resistance to abrasive wear and high strength. These features are obtained by using advanced technology of manufacturing. This makes boron steels increasingly popular and their application more diverse. Application of these steels can extend the lifetime of very expensive machine construction in many industries such as mining, the automotive, and agriculture industries. An interesting subgroup of these materials is steel with boron intended for heat treatment. These steels are supplied by the manufacturer after cold or hot rolling so that it is possible for them to be heat treated in a suitable manner by the purchaser for its specific application. Very important factor that determines the mechanical properties of final product is austenite grain growth occurring during hot working process such us quenching or hot rolling. Investigation of the effect of heating temperature and holding time on the austenite grain size is necessary to understand the growth behavior under different conditions. This article presents the result of investigation of austenite grain growth in selected low-allow boron steel with high resistance to abrasive wear and attempts to describe the influence of chemical composition on this process.

  14. Fabrication of a 77 GHz Rotman Lens on a High Resistivity Silicon Wafer Using Lift-Off Process

    Directory of Open Access Journals (Sweden)

    Ali Attaran

    2014-01-01

    Full Text Available Fabrication of a high resistivity silicon based microstrip Rotman lens using a lift-off process has been presented. The lens features 3 beam ports, 5 array ports, 16 dummy ports, and beam steering angles of ±10 degrees. The lens was fabricated on a 200 μm thick high resistivity silicon wafer and has a footprint area of 19.7 mm × 15.6 mm. The lens was tested as an integral part of a 77 GHz radar where a tunable X band source along with an 8 times multiplier was used as the RF source and the resulting millimeter wave signal centered at 77 GHz was radiated through a lens-antenna combination. A horn antenna with a downconverter harmonic mixer was used to receive the radiated signal and display the received signal in an Advantest R3271A spectrum analyzer. The superimposed transmit and receive signal in the spectrum analyzer showed the proper radar operation confirming the Rotman lens design.

  15. Primary defect transformations in high-resistivity p-type silicon irradiated with electrons at cryogenic temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Makarenko, L.F., E-mail: makarenko@bsu.b [Department of Applied Mathematics and Computer Science, Belarusian State University, Independence Ave. 4, 220030 Minsk (Belarus); Lastovski, S.B.; Korshunov, F.P.; Murin, L.I. [Scientific-Practical Materials Research Centre of NAS of Belarus, Minsk (Belarus); Moll, M. [CERN, Geneva (Switzerland)

    2009-12-15

    It has been revealed that self-interstitials formed under low intensity electron irradiation in high resistivity p-type silicon can be retained frozen up to room temperature. Low thermal mobility of the self-interstitials suggests that Frenkel pairs in silicon can be stable at temperatures of about or higher than 100 K. A broad DLTS peak with activation energy of 0.14-0.17 eV can be identified as related to Frenkel pairs. This peak anneals out at temperatures of 120-140 K. Experimental evidences are presented that becoming more mobile under forward current injection the self-interstitials change their charge state to a less positive one.

  16. Morphological properties of the action-observation cortical network in adolescents with low and high resistance to peer influence.

    Science.gov (United States)

    Paus, Tomás; Toro, Roberto; Leonard, Gabriel; Lerner, Jacqueline V; Lerner, Richard M; Perron, Michel; Pike, G Bruce; Richer, Louis; Steinberg, Laurence

    2008-01-01

    Children with high resistance to peer influences differ from their low-resistance counterparts in the degree of functional connectivity in fronto-parietal and prefrontal cortical networks. Here we explored the possibility that the degree of morphological similarities across the same cortical regions also varies as a function of this behavioral trait. Using structural magnetic-resonance (MR) images, we measured cortical thickness in a total of 295 adolescents (12 to 18 years of age). We found that inter-regional correlations in cortical thickness increased with the resistance to peer influence (RPI); this was especially the case, in female adolescents, in the premotor and prefrontal networks. We also observed significant differences between the adolescents with high and low RPI scores in their general intelligence and the scores of positive youth development. We suggest that these morphological findings might reflect differences, between adolescents with high vs. low resistance to peer influences, in a repeated and concurrent engagement of these networks in social context.

  17. Analysis of divacancy related traps induced by proton, neutron and gamma radiation in high resistivity silicon detectors

    CERN Document Server

    Eremin, V; Verbitskaya, E; Li, Z; Pandey, S U

    1999-01-01

    Defects with deep levels induced in high-resistivity silicon detectors by low and high radiation fluence of protons and neutrons are studied using capacitance and current DLTS. Numerical simulation of I-DLTS and C-DLTS spectra based on the model of charge carrier emission and redistribution of electric field in the detector enabled one to perform the detailed investigation of DLTS spectra. It has been shown that the main DLTS peak in the range of 200 to 260 K may be considered as a result of the interference of deep levels near the midgap - negatively charged divacancy VV sup - and the C sub i -O sub i complex. The model describing the broadening of the VV sup - component of the spectrum, which arises from the divacancy localization inside a cluster, is discussed. The results are compared with those obtained for gamma irradiation, for which the dominant contribution in DLTS spectra arises just from the C sub i -O sub i complex.

  18. Microbiome-metabolome responses in the cecum and colon of pig to a high resistant starch diet

    Directory of Open Access Journals (Sweden)

    Yue eSun

    2016-05-01

    Full Text Available Currently, knowledge about the impact of long-term intake of high resistant starch diet on pig hindgut microbiota and metabolite profile is limited. In this study, a combination of the pyrosequencing and the mass spectrometry (MS-based metabolomics techniques were used to investigate the effects of a raw potato starch (RPS, high in resistant starch diet on microbial composition and microbial metabolites in the hindgut of pig. The results showed that Coprococcus, Ruminococcus, and Turicibacter increased significantly, while Sarcina and Clostridium decreased in relative abundances in the hindgut of pigs fed RPS. The metabolimic analysis revealed that RPS significantly affected starch and sucrose metabolites, amino acid turnover or protein biosynthesis, lipid metabolites, glycolysis, the pentose phosphate pathway, inositol phosphate metabolism, and nucleotide metabolism. Furthermore, a Pearson’s correlation analysis showed that Ruminococcus and Coprococcus were positively correlated with glucose-6-phosphate, maltose, arachidonic acid, 9, 12-octadecadienoic acid, oleic acid, phosphate, but negatively correlated with α-aminobutyric acid. However, the correlation of Clostridium and Sarcina with these compounds was in the opposite direction. The results suggest that RPS not only alters the composition of the gut microbial community but also modulates the metabolic pathway of microbial metabolism, which may further affect the hindgut health of the host.

  19. Electrodeposited ZnO-nanowire/Cu₂O photovoltaic device with highly resistive ZnO intermediate layer.

    Science.gov (United States)

    Izaki, Masanobu; Ohta, Takayuki; Kondo, Misaki; Takahashi, Toshiaki; Mohamad, Fariza Binti; Zamzuri, Mohd; Sasano, Junji; Shinagawa, Tsutomu; Pauporté, Thierry

    2014-08-27

    Cl-doped ZnO-nanowire (Cl:ZnO-nws)/Cu2O photovoltaic devices were prepared by electrodeposition in aqueous solutions, and the effects of the insertion of the highly resistive ZnO (i-ZnO) layer has been demonstrated by an improvement of the photovoltaic performance. The Cl:ZnO-nws and i-ZnO layer were prepared by electrodeposition in a zinc chloride aqueous solution with saturated molecular oxygen and simple zinc nitrate aqueous solution, respectively. The i-ZnO layer was directly deposited on the Cl:ZnO-nws and suppressed the electrodeposition of the Cu2O layer on the Cl:ZnO-nws. The insertion of the i-ZnO layer between the Cl:ZnO-nws and Cu2O layers induced an improvement in the photovoltaic performance from 0.40 to 1.26% with a 0.35 V open circuit voltage, 7.1 mA·cm(-2) short circuit current density, and 0.52 fill factor due to the reduction of the recombination loss.

  20. The annealing of interstitial carbon atoms in high-resistivity n-type silicon after proton irradiation

    CERN Document Server

    Kuhnke, M; Lindström, G

    2002-01-01

    The annealing of interstitial carbon C sub i after 7-10 MeV and 23 GeV proton irradiations at room temperature in high-resistivity n-type silicon is investigated. Deep level transient spectroscopy is used to determine the defect parameters. The annealing characteristics of the impurity defects C sub i , C sub i C sub s , C sub i O sub i and VO sub i suggest that the mobile C sub i atoms are also captured at divacancy VV sites at the cluster peripheries and not only at C sub s and O sub i sites in the silicon bulk. The deviation of the electrical filling characteristic of C sub i from the characteristic of a homogeneously distributed defect can be explained by an aggregation of C sub i atoms in the environment of the clusters. The capture rate of electrons into defects located in the cluster environment is reduced due to a positive space charge region surrounding the negatively charged cluster core. The optical filling characteristic of C sub i suggests that the change of the triangle-shaped electric field dis...

  1. Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.

    Science.gov (United States)

    Agniswamy, Johnson; Louis, John M; Shen, Chen-Hsiang; Yashchuk, Sofiya; Ghosh, Arun K; Weber, Irene T

    2015-06-25

    An extremely drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has been studied with two potent antiviral investigational inhibitors. GRL-5010A and GRL-4410A were designed to introduce hydrogen bond interactions with the flexible flaps of the PR by incorporating gem-difluorines and alkoxy, respectively, at the C4 position of the bis-THF of darunavir. PR20 provides an excellent model for high level resistance, since clinical inhibitors are >1000-fold less active on PR20 than on wild-type enzyme. GRL-5010A and GRL-4410A show inhibition constants of 4.3 ± 7.0 and 1.7 ± 1.8 nM, respectively, for PR20, compared to the binding affinity of 41 ± 1 nM measured for darunavir. Crystal structures of PR20 in complexes with the two inhibitors confirmed the new hydrogen bond interactions with Gly 48 in the flap of the enzyme. The two new compounds are more effective than darunavir in inhibiting mature PR20 and show promise for further development of antiviral agents targeting highly resistant PR mutants.

  2. The effects of high resistance-few repetitions and low resistance-high repetitions resistance training on climbing performance.

    Science.gov (United States)

    Hermans, Espen; Andersen, Vidar; Saeterbakken, Atle Hole

    2017-05-01

    The aim of the study was to compare the effects of different strength training intensities on climbing performance, climbing-specific tests and a general strength test. Thirty lower grade and intermediate-level climbers participated in a 10-week training programme. The participants were randomized into three groups: high resistance-few repetitions training groups (HR-FR), low resistance-high repetitions training groups (LR-HR) and a control group (CON) which continued climbing/training as usual. Post-testing results demonstrated statistical tendencies for climbing performance improvements in the HR-FR and LR-HR (p = 0.088-0.090, effect size = 0.55-0.73), but no differences were observed between the groups (p = 0.950). For the climbing-specific tests, no differences were observed between the groups (p = 0.507-1.000), but the HR-FR and LR-HR improved their time in both Dead-hang (p = 0.004-0.026) and Bent-arm hang (p climbing sessions during the intervention compared to the CON group (p = 0.057-0.074). In conclusion, HR-FR and LR-HR training programmes demonstrated an 11% and 12% non-significant improvement in climbing performance despite a 50% reduction in climbing sessions, but improved the results in strength and climbing-specific tests. None of the training intensities was superior compared to the others.

  3. Characteristics of spring wheat genotypes exhibiting high resistance to FHB in terms of their resistance to other fungal diseases

    Directory of Open Access Journals (Sweden)

    Danuta Kurasiak-Popowska

    2016-09-01

    Full Text Available The field experiment was carried out in 2010–2012 at the Dłoń Agricultural Research Station, the Poznań University of Life Sciences, Poland. The study was designed to evaluate the degree of infection by powdery mildew, brown rust, and septoria leaf blotch in 61 spring wheat genotypes differing in their resistance to Fusarium ssp. The vast majority of spring wheat genotypes in the collection of gene resources in the USA defined as resistant to Fusarium ssp. confirmed their resistance under Polish climatic conditions. The B .graminis infection rate of genotypes that are considered to be resistant to Fusarium head blight was high. The resistance ranged from 7 for Sumai 3 (PL2 up to 8.8 for Ning 8331 (in a 9-point scale. Most of the genotypes (56.5% were infected by Puccinia recondita at a level of 1–3 (in a 9-point scale. The genotypes of Sumai 3 exhibited high resistance to septoria leaf blotch, amounting to 1–2 in a 9-point scale; the resistance of Frontana ranged from 1 to 3.5, while the genotypes of Ning were infected by Mycosphaerella graminicola at 5–6.

  4. Alterations in Skeletal Muscle Function with Microgravity, and the Protective Effects of High Resistance Isometric and Isotonic Exercise

    Science.gov (United States)

    Fitts, R. H.; Hurst, J. E.; Norenberg, K. M.; Widrick, J. J.; Riley, D. A.; Bain, J. L. W.; Trappe, S. W.; Trappe, T. A.; Costill, D. L.

    1999-01-01

    Exposure to microgravity or models designed to mimic the unloaded condition, such as bed rest in humans and hindlimb unloading (HU) in rats leads to skeletal muscle atrophy, a loss in peak force and power, and an increased susceptibility to fatigue. The posterior compartment muscles of the lower leg (calf muscle group) appear to be particularly susceptible. Following only 1 wk in space or HU, rat soleus muscle showed a 30 to 40% loss in wet weight. After 3 wk of HU, almost all of the atrophied soleus fibers showed a significant increase in maximal shortening velocity (V(sub 0)), while only 25 to 30 % actually transitioned to fast fibers. The increased V(sub 0), was protective in that it reduced the decline in peak power associated with the reduced peak force. When the soleus is stimulated in situ following HU or zero-g one observes an increased rate and extent of fatigue, and in the former the increased fatigue is associated with a more rapid depletion of muscle glycogen and lactate production. Our working hypothesis is that following HU or spaceflight in rats and bed rest or spaceflight in humans limb skeletal muscles during contractile activity depend more on carbohydrates and less on fatty acids for their substrate supply. Baldwin et al. found 9 days of spaceflight to reduce by 37% the ability of both the high and low oxidative regions of the vastus muscle to oxidize long-chain fatty acids. This decline was not associated with any change in the enzymes of the tricarboxylic acid cycle or oxidation pathway. The purpose of the current research was to establish the extent of functional change in the slow type I and fast type H fibers of the human calf muscle following 17 days of spaceflight, and determine the cellular mechanisms of the observed changes. A second goal was to study the effectiveness of high resistance isotonic and isometric exercise in preventing the deleterious functional changes associated with unloading.

  5. High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase.

    Science.gov (United States)

    Wilusz, Rebecca E; Guilak, Farshid

    2014-10-01

    In articular cartilage, the extracellular matrix (ECM) and chondrocyte-associated pericellular matrix (PCM) are characterized by a high concentration of proteoglycans (PGs) and their associated glycosaminoglycans (GAGs). These molecules serve important biochemical, structural, and biomechanical roles in the tissue and differences in their regional distributions suggest that different GAG/PG species contribute to the specific biomechanical properties of the ECM and PCM. The objective of this study was to investigate region-specific contributions of aggrecan, chondroitin and dermatan sulfate, and hyaluronan to the micromechanical properties of articular cartilage PCM and ECM in situ. Cryosections of porcine cartilage underwent digestion with ADAMTS-4, chondroitinase ABC, bacterial hyaluronidase or human leukocyte elastase. Guided by immunofluorescence for type VI collagen, AFM stiffness mapping was used to evaluate the elastic properties of matched PCM and ECM regions in paired control and digested cartilage sections. These methods were used to test the hypotheses that specific enzymatic digestion of GAGs or PGs would reduce both PCM and ECM elastic moduli. Elastase, which digests a number of PGs, some types of collagen, and non-collagenous proteins, was used as a positive control. ECM elastic moduli were significantly reduced by all enzyme treatments. However, PCM micromechanical properties were unaffected by enzymatic digestion of aggrecan, chondroitin/dermatan sulfate, and hyaluronan but were significantly reduced by 24% following elastase digestion. Our results provide new evidence for high resistance of PCM micromechanical properties to PG digestion and suggest a potential role for elastase in the degradation of the ECM and PCM. © 2013 Published by Elsevier Ltd.

  6. Responses in colonic microbial community and gene expression of pigs to a long-term high resistant starch diet

    Directory of Open Access Journals (Sweden)

    Yue eSun

    2015-08-01

    Full Text Available Intake of raw potato starch (RPS has been associated with various intestinal health benefits, but knowledge of its mechanism in a long-term is limited. The aim of this study was to investigate the effects of long-term intake of RPS on microbial composition, genes expression profiles in the colon of pigs. Thirty-six Duroc × Landrace × Large White growing barrows were randomly allocated to corn starch (CS and RPS groups with a randomized block design. Each group consisted of six replicates (pens, with three pigs per pen. Pigs in the CS group were offered a corn/soybean-based diet, while pigs in the RPS group were put on a diet in which 230 g/kg (growing period or 280 g/kg (finishing period purified corn starch was replaced with purified RPS during a 100-day trial. Real-time PCR assay showed that RPS significantly decreased the number of total bacteria in the colonic digesta. MiSeq sequencing of the V3-V4 region of the 16S rRNA genes showed that RPS significantly decreased the relative abundance of Clostridium, Treponema, Oscillospira, Phascolarctobacterium, RC9 gut group, and S24-7-related operational taxonomic units (OTUs, and increased the relative abundance of Turicibacter, Blautia, Ruminococcus, Coprococcus, Marvinbryantia, and Ruminococcus bromii-related OTUs in colonic digesta and mucosa. Analysis of the colonic transcriptome profiles revealed that the RPS diet changed the colonic expression profile of the host genes mainly involved in immune response pathways. RPS significantly increased proinflammartory cytokine IL-1β gene expression and suppressed genes involved in lysosome. Our findings suggest that long-term intake of high resistant starch (RS diet may result in both positive and negative roles in gut health.

  7. Prevalence, risk factors and molecular epidemiology of highly resistant gram negative rods in hospitalized patients in the Dutch region Kennemerland

    Directory of Open Access Journals (Sweden)

    Dennis Souverein

    2016-03-01

    Full Text Available Abstract Background This paper describes (1 the Highly Resistant Gram Negative Rod (HR-GNR prevalence rate, (2 their genotypes, acquired resistance genes and (3 associated risk factors of HR-GNR colonization among the hospitalized population in the Dutch region Kennemerland. Methods Between 1 October 2013 and 31 March 2014, cross-sectional prevalence measurements were performed in three regional hospitals as part of each hospitals infection control program. Rectal swabs were analyzed at the Regional Public Health Laboratory Kennemerland by direct culturing. Genotypes and acquired resistance genes of positive isolates were determined using Whole Genome Sequencing with the MiSeq instrument (Illumina. Association between several independent variables and HR-GNR positivity was examined using logistic regression models. Results Out of 427 patients, 24 HR-GNR positive isolates were recovered from 22 patients, resulting in a regional HR-GNR colonization prevalence (95 % CI of 5.2 % (3.6–7.9. Of these 22 positive patients, 15 were Extended Spectrum Beta-Lactamase (ESBL positive (3.5 % (2.1–5.7, 7 patients were positive for a Fluoroquinolones and Aminoglycosides (Q&A resistant Enterobacteriaceae (1.6 % (0.8–3.3 and from one patient (0.2 % (0–1.3 a Stenotrophomonas maltophilia resistant towards co-trimoxazole was isolated. No carbapenemase producing Enterobacteriaceae (CPE, multi-resistant Acinetobacter species or multi-resistant Pseudomonas aeruginosa were isolated. The ESBL genes found were bla CTX-M-1 (n = 4, 25.0 %, bla CTX-M-15 (n = 3, 18.8 %, bla CTX-M-27 (n = 2, 12.5 %, bla CTX-M-14b (n = 2, 12.5 %, bla CTX-M-9 (n = 2, 12.5 %, bla CTX-M-14 (n = 1, 6.3 %, bla CTX-M-3 (n = 1, 6.3 %, bla SHV-11 (n = 1, 6.3 % and bla SHV-12 (n = 1, 6.3 %. Being known HR-GNR positive in the past was the only significant associated risk factor for HR-GNR positivity, odds ratio (95 % CI: 7.32 (1.82–29.35, p

  8. Performances of RPCs in the BaBar Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Messner, Robert

    2003-09-26

    The BaBar experiment uses a big system based on RPC detectors to discriminate muons from pions and to identify neutral hadrons. About 2000 m{sup 2} of RPC chambers have been working at SLAC since the end of 1998. We report on the performances of the RPC chambers focusing on new problems discovered in the RPC behavior. These problems started very soon after the installation of the chambers on the detector when the high ambient temperature triggered an increase of dark currents inside the chambers and a reduction of the efficiency. Careful analysis of the BaBar data and dedicated R&D efforts in the laboratory have helped to identify the main source of the trouble in the linseed oil varnish on the bakelite electrodes.

  9. Methodology of evaluating the influence of the resistance of contact regions in the measurements of sheet resistance on stripes of ultrathin high-resistance materials.

    Science.gov (United States)

    Náhlík, Josef; Kašpárková, Irena; Fitl, Přemysl

    2012-07-01

    The paper reviews the problems of measurement of sheet resistance of ultrathin high-resistance layers of organic semiconductors and the essential underlying problems. Particular attention is paid to potential influence of the resistance of contact regions on the results of direct measurement of sheet resistance of stripe-shaped layers. In this connection, we present a methodology of double length stripe resistance measurement (DLSRM), used above all to minimise the influence of contact regions on the measurement results. We deduce theoretical as well as practical possibilities of DLSRM in the diagnostics and quantitative characterisation of unsuitable or even faulty contacts on high-resistance layers. The application efficiency of the DLSRM method is documented by the results of sheet resistance measurement on zinc phthalocyanine with cathode sputtered planar contacts of noble metals (gold, platinum, or palladium). As expected, gold is the best contact material, but even in its application one cannot neglect the influence of contact regions. The presented method is universal and generally applicable to all materials where sheet resistance is the relevant parameter, and its assessment is based on measurements of the layer resistance in stripe arrangement.

  10. Ultra-high resistive and anisotropic CoPd–CaF{sub 2} nanogranular soft magnetic films prepared by tandem-sputtering deposition

    Energy Technology Data Exchange (ETDEWEB)

    Naoe, Masayuki, E-mail: naoe@denjiken.ne.jp [Research Institute for Electromagnetic Materials, 2-1-1 Yagiyama-Minami, Taihaku-ku, Sendai 982-0807 (Japan); Kobayashi, Nobukiyo [Research Institute for Electromagnetic Materials, 2-1-1 Yagiyama-Minami, Taihaku-ku, Sendai 982-0807 (Japan); Ohnuma, Shigehiro [Research Institute for Electromagnetic Materials, 2-1-1 Yagiyama-Minami, Taihaku-ku, Sendai 982-0807 (Japan); Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-aza-Aoba, Aoba-ku, Sendai 980-8578 (Japan); Iwasa, Tadayoshi; Arai, Ken-Ichi [Research Institute for Electromagnetic Materials, 2-1-1 Yagiyama-Minami, Taihaku-ku, Sendai 982-0807 (Japan); Masumoto, Hiroshi [Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-aza-Aoba, Aoba-ku, Sendai 980-8578 (Japan)

    2015-10-01

    Ultra-high resistive and anisotropic soft magnetic films for gigahertz applications are desirable to demonstrate the really practical films. Here we present a study of novel nanogranular films fabricated by tandem-sputtering deposition. Their electromagnetic properties and nanostructure have also been discussed. These films consisted of nanocrystallized CoPd alloy-granules and CaF{sub 2} matrix, and a specimen having a composition of (Co{sub 0.69}Pd{sub 0.31}){sub 52}–(Ca{sub 0.31}F{sub 0.69}){sub 48} exhibited distinct in-plane uniaxial anisotropy after uniaxial field annealing with granule growth. Its complex permeability spectra have a ferromagnetic resonance frequency extending to the Super-High-Frequency band due to its higher anisotropy field, and its frequency response was quite well reproduced by a numerical calculation based on the Landau–Lifshitz–Gilbert equation. Furthermore, it was clarified that the CaF{sub 2}-based nanogranular film exhibits a hundredfold higher electrical resistivity than conventional oxide or nitride-based films. Higher resistivity enables the film thickness to achieve a margin exceeding threefold against eddy current loss. The greater resistivity of nanogranular films is attributed to the wide energy bandgap and superior crystallinity of CaF{sub 2} matrix. - Highlights: • We fabricated high-resistive and anisotropic granular films by tandem-sputtering. • CaF{sub 2}-based films exhibit a hundredfold higher resistivity than conventional films. • Uniaxial field annealing improved the magnetic properties dramatically. • High uniaxial anisotropy extended ferromagnetic resonance frequency to 4 GHz. • Annealed samples can be regarded as a ferromagnetic homogenized material.

  11. Direct observation and measurements of neutron induced deep levels responsible for N{sub eff} changes in high resistivity silicon detectors using TCT

    Energy Technology Data Exchange (ETDEWEB)

    Li, Z.; Li, C.J. [Brookhaven National Lab., Upton, NY (United States); Eremin, V.; Verbitskaya, E. [AN SSSR, Leningrad (Russian Federation). Fiziko-Tekhnicheskij Inst.

    1996-03-01

    Neutron induced deep levels responsible for changes of space charge concentration {ital N{sub eff}} in high resistivity silicon detectors have been observed directly using the transient current technique (TCT). It has been observed by TCT that the absolute value and sign of {ital N{sub eff}} experience changes due to the trapping of non- equilibrium free carriers generated near the surface (about 5 micrometers depth into the silicon) by short wavelength laser pulses in fully depleted detectors. Electron trapping causes {ital N{sub eff}} to change toward negative direction (or more acceptor-like space charges) and hole trapping causes {ital N{sub eff}} to change toward positive direction (or more donor-like space charges). The specific temperature associated with these {ital N{sub eff}} changes are those of the frozen-up temperatures for carrier emission of the corresponding deep levels. The carrier capture cross sections of various deep levels have been measured directly using different free carrier injection schemes. 10 refs., 12 figs., 3 tabs.

  12. Molecular Cytogenetic Characterization of Novel Wheat-rye T1RS.1BL Translocation Lines with High Resistance to Diseases and Great Agronomic Traits

    Directory of Open Access Journals (Sweden)

    Tianheng Ren

    2017-05-01

    Full Text Available Rye has been used worldwide as a source for the genetic improvement of wheat. In this study, two stable wheat-rye primary T1RS.1BL translocation lines were selected from the progeny of the crossing of the wheat cultivar Mianyang11-1 and a Chinese local rye variety, Weining. These two novel translocation lines were identified by molecular cytogenetic analysis. PCR results, multi-color fluorescence in situ hybridization (MC-FISH, and acid polyacrylamide gel electrophoresis (A-PAGE indicated that both new translocation lines harbor a pair of T1RS.1BL translocation chromosomes, and have been named RT828-10 and RT828-11, respectively. The cytogenetic results also indicated that the pSc119.2 signals of 5AL were absent in both lines along with the pSc119.2 signals of 4AL of RT828-11. When inoculated with different stripe rust and powdery mildew isolates, both lines expressed high resistance to Puccinia striiformis f. sp. tritici and Blumeria graminis f. sp. tritici pathotypes, which are prevalent in China and are virulent on Yr9 and Pm8. The line RT828-11 also exhibited excellent agronomic traits in the field. The present study indicates that this rye variety may carry untapped variations that could potentially be used for wheat improvement.

  13. The Monitor online system of the OPERA muon magnetic spectrometer

    CERN Document Server

    Ugolino, U.; Acquafredda, R.; Masone, v.

    2008-01-01

    The OPERA muon magnetic spectrometer has been designed for muon detection, tracking and timing. The 44 bakelite Resistive Chambers (RPC) planes, imbibed inside the magnet iron slabs, must provide the tracking of the muon curved in the magnetic field to ease the momentum and charge measurement provided by the HPT. Furthermore, it provides the momentum for muons stopping in the iron. RPC signals will be also used as start of drift tube acquisition thanks to the very good time resolution of RPC detectors. Due to the required performances the tracking detector must be fully efficient and stable. In this conditions an online monitor is mandatory to continuously control stability of run conditions. We report the main characteristics and performances of the monitor system for the OPERA spectrometer and capabilities of the software developed for settings and data acquisition.

  14. Study of the impact of environmental parameters on the operation of CMS RPCs

    CERN Document Server

    Assran, Yasser

    2011-01-01

    CMS (Compact Muon Solenoid) is a general purpose detector designed to run at the highest luminosity at Large Hadron Collider (LHC), CERN, Geneva, Switzerland. The muon system of the CMS experiment relies on Drift Tubes (DT), Cathode Strip Chambers (CSC) and Resistive Plate Chambers (RPC). RPCs are dedicated for the first level muon trigger and they are characterized by bakelite electrodes delimited in a specialized gas volume filled with operational gas mixture. This analysis has been done for the RPC chambers installed in CMS experiment at CERN. The Currents of CMS RPCs chambers are analyzed as a function of environmental parameters such as Temperature, Humidity and pressure, which are important for the operation of the muon detector system. A novel Neural Network approach has been used to analyze the data and to build a model using experimental measurements and combining the results of the simulations. Data from RPC Chambers in CMS experiment are taken and compared to the results from neural Network.

  15. Streptococcus pneumoniae: low frequency of penicillin resistance and high resistance to trimethoprim-sulfamethoxazole in nasopharyngeal isolates from children in a rural area in Mexico.

    Science.gov (United States)

    Miranda Novales, M G; Solorzano Santos, F; Guiscafre Gallardo, H; Leaños Miranda, B; Echaniz Aviles, G; Carnalla Barajas, M N; Palafox Torres, M; Muñoz Hernandez, O

    1997-01-01

    the treatment of S. pneumoniae lower respiratory tract infections. It is necessary to perform clinical assays to evaluate the efficacy of trimethoprim-sulfamethoxazole due to the high resistance in vitro.

  16. [Isolation and identification of a bacterial strain KHg2 with high resistance to mercury and cloning and expression of its merA gene].

    Science.gov (United States)

    Zeng, Yan; Chen, Qiang; Wang, Min; Sun, Jianguang; Gao, Junlian

    2009-12-01

    The aim of our study was to isolate and identify merA gene from a bacterial strain with high resistance to mercury. A bacterial strain with resistance to mercury was isolated from the river sediment of Liangshui river in Beijing. The strain was identified according to the sequence analysis of 16S rRNA gene and its physiological and biochemical properties. A pair of PCR primers was designed according to the merA gene sequences of some bacteria published in the GeneBank to amplify the complete merA gene using the genomic DNA of KHg2 as a template. The PCR-amplified DNA fragment was expressed in Escherichia coli BL21 (DE3). Mercury resistance of the expression strain was tested. A bacterial strain which could grew on LB medium plate containing 70 mg/L HgCl2 was isolated, it was named as KHg2. The strain KHg2 shares 96% sequence identity with the type strain DSM12223T of Bacillus silvestris. The morphological characteristics and the results of physiological and biochemical properties of the strain were agreement with that of Bacillus silvestris. One PCR fragment of 1680 bp was obtained from the strain, which shares 99% sequence identity with merA gene of Pseudomonas putida. The PCR-amplified DNA fragment was cloned into a pET-30a (+) vector to obtain a expression plasmid pZY2. The expression plasmid was transformed into E. coil host strain to obtain a expression strain E. coli BL21 (DE3) x pZY2, a protein of 33 kDa was expressed by the expression strain after induced with isopropyl-b-D-thiogalactoside (IPTG). The result of heavy metal resistance test showed that the expression strain could grew on LB medium containing 20 mg/L HgCl2, meanwhile a negative control, E. coli BL21 (DE3), harbouring pET-30a (+), could not grew on LB medium containing 20 mg/L HgCl2. The isolated strain KHg2 was closely related to Bacillus silvestris. A merA gene was cloned from the strain KHg2 and was expressed successfully in E. coli. The expression strain E. coli BL21 (DE3) x pZY2 has

  17. Temperature and humidity dependence of bulk resistivity of bakelite for resistive plate chambers in CMS

    CERN Document Server

    Ahn, S H; Bahk, S Y; Gapienko, V A; Hong, B; Hong, S J; Jung, S Y; Kim, J Y; Kim, Y J; Kim, Y U; Koo, D G; Lee, K S; Lee, S J; Lee, Y L; Lim, I T; Nam, S K; Pac, M Y; Park, S K; Ra, Y S; Rhee, J T; Seo, S W; Sim, K S

    2000-01-01

    This paper presents data obtained in a systematic study on the bulk resistivity of Korean bakelike as a function of temperature in the range 20-30 degrees C and relative humidity in the range 35-65%. Strong dependence of resistivity on both temperature and humidity was observed. Measurements were carried out in the framework of R&D work on resistive plate chambers which will be used in the CMS detector. (4 refs).

  18. The CMS RPC project, results from 2009 cosmics data taking

    CERN Document Server

    Carrillo Montoya, Camilo Andres

    2010-01-01

    The Resistive Plate Chambers are used in the CMS experiment as a dedicated muon trigger both in barrel and endcap system. About 4000 square meter of double gap RPCs have been produced and have been installed in the experiment since 2007. The full barrel system and a fraction of the endcaps have been extensively commisioned with milions of cosmic rays collected by the full CMS experiment. Making use of the redundant muon system composed by Drift Tube in the barrel and CSC in the endcaps that provide independent tracking and trigger informations, the performances of the RPCs have been studied in terms of efficiency, cluster size multiplicity, spatial resolution and trigger response. Moreover during the long period of detector operations the stability of the system has been monitored to study the dark currents and noise behavior as a function of time. First results obtained using the cosmic rays data taken in the 2008 and 2009 will be reported here.

  19. High counting rate, two-dimensional position sensitive timing RPC

    CERN Document Server

    Petrovici, M.; Simion, V; Bartos, D; Caragheorgheopol, G; Deppner, I; Adamczewski-Musch, J; Linev, S; Williams, MCS; Loizeau, P; Herrmann, N; Doroud, K; Radulescu, L; Constantin, F

    2012-01-01

    Resistive Plate Chambers (RPCs) are widely employed as muon trigger systems at the Large Hadron Collider (LHC) experiments. Their large detector volume and the use of a relatively expensive gas mixture make a closed-loop gas circulation unavoidable. The return gas of RPCs operated in conditions similar to the experimental background foreseen at LHC contains large amount of impurities potentially dangerous for long-term operation. Several gas-cleaning agents, characterized during the past years, are currently in use. New test allowed understanding of the properties and performance of a large number of purifiers. On that basis, an optimal combination of different filters consisting of Molecular Sieve (MS) 5Å and 4Å, and a Cu catalyst R11 has been chosen and validated irradiating a set of RPCs at the CERN Gamma Irradiation Facility (GIF) for several years. A very important feature of this new configuration is the increase of the cycle duration for each purifier, which results in better system stabilit...

  20. The Induced Charge Signal of Glass RPC Detector

    CERN Document Server

    Ran, Han

    2013-01-01

    The gas detector glass resistivity parallel chamber (GRPC) is proposed to use in the Hadron calorimeter (HCAL), the read-out system is based on the semi-digital system, then the charge information from GRPC is needed. To better understand the charge comes out from GRPC, we started from cosmic ray test to get the charge distribution and then study the induced charge distribution on the collection pad, after successfully compared with the prototype beam test data at CERN (European Council for Nuclear Research), the process was finally implanted into the Geant4 based simulation for future study.

  1. 75 FR 16499 - Royalty Policy Committee (RPC) Notice of Renewal

    Science.gov (United States)

    2010-04-01

    ... management of Federal and Indian mineral leases and revenues under the laws governing the Department of the Interior. The Committee will also review and comment on revenue management and other mineral and energy.... FOR FURTHER INFORMATION CONTACT: Ms. Gina Dan, Minerals Revenue Management, Minerals Management...

  2. HL LHC perspectives for the ATLAS RPC system

    CERN Document Server

    Aielli, G; The ATLAS collaboration

    2014-01-01

    The architecture of the present muon trigger detector was conceived in the early nineties having in mind a fast, robust and simple device. According to the Atlas requirements the ageing qualification were done taking a reference luminosity of 1034 cm-2 s-1included a safety factor of 5 with respect to the simulated background rates. The experience made so far has shown that the average rate measured in 2012 LHC run is very close to the predicted one, however it is unevenly distributed in the barrel: the chambers at the barrel edge (i.e. higher eta values) show rates of about a factor of 2.5 higher than the average thus absorbing part of the safety factor. In the next decade, ATLAS will run with an increasing luminosity and beam energy resulting in much higher background rate, up to almost one order of magnitude with respect to the present condition. This will affect both the detector rate capability and robustness against the ageing effects and the demand of trigger performance to increase the muon momentum se...

  3. The CMS RPC detector performance during Run-2 data taking

    CERN Document Server

    Shah, Mehar Ali

    2017-01-01

    The CMS experiment, located at the CERN Large Hadron Collider, has a redundant muon system composed by three different detector technologies Cathode Strip Chambers (in the forward regions), Drift Tubes (in the central region), and Resistive Plate Chambers (both in the central and forward regions). The RPCs are designed mainly as a trigger detector but they contribute also to the muon reconstruction. Thus the monitoring and the analysis of the system performance are necessary and essential for the final data quality. The main detector characteristics and the hit efficiency and cluster size will be presented in the paper. The stability of the system in the conditions of high instantaneous luminosity and high number of PU events will be presented in a view of history monitoring and stable trend.

  4. The LECCE cosmic ray testing facility for the ATLAS RPC

    Science.gov (United States)

    Bianco, M.; Cataldi, G.; Chiodini, G.; Coluccia, M. R.; Gorini, E.; Grancagnolo, F.; Perrino, R.; Primavera, M.; Spagnolo, S.; Tassielli, G.

    2006-09-01

    A detailed description of a dedicated facility built in the Lecce INFN and Physics Department High Energy Laboratory to test part of the Resistive Plate Counters (RPCs) of the ATLAS barrel muon spectrometer is presented. In this cosmic ray test stand the chambers are operated for the first time, after being assembled and equipped with all required services for gas and electrical connections. A complete set of measurements is performed on each chamber in order to certificate its quality and performances before the installation in the experiment.

  5. Proposal for the RPC muon detector of LHCb

    CERN Document Server

    Adinolfi, M; Calvetti, M; Carboni, G; Iacopini, E; Messi, R; Pacciani, L; Passaleva, G; Santovetti, E; Santovetti, Emanuele

    2000-01-01

    2000-053 We propose to use RPCs to equip a substantial part of the muon detector stations M2-M5. RPCs made of phenolic plates of low resistivity (9 10^9 ohm-cm) and operated in avalanche mode offer very good performance and several advantages in region IV of M2-M5 and in region III of M4-M5. Using this technique it is possible to cover 75 % of the total area behind the calorimeters at moderate cost.

  6. Highly efficient resistive plate chambers for high rate environment

    CERN Document Server

    Cwiok, M; Górski, M; Królikowski, J

    1999-01-01

    The full scale prototype of an inverted double gap RPC module for ME-1/1 station of the CMS detector was tested in the gamma irradiation facility at the CERN SPS muon beam. The chamber made of medium resistivity bakelite and filled with "green gas" mixture of C /sub 2/H/sub 2/F/sub 4//iso-butane/SF/sub 6/ has wide efficiency plateau and good timing properties when operated in avalanche mode under continuous irradiation with strong /sup 137/Cs source for rates up to about 5 kHz/cm/sup 2//gap. (10 refs).

  7. Effect of total alkaloid extract of local Sophora alopecuroides on minimum inhibitory concentration and intracellular accumulation of ciprofloxacin, and acrA expression in highly resistant Escherichia coli clones.

    Science.gov (United States)

    Pourahmad Jaktaji, Razieh; Mohammadi, Parvin

    2017-09-20

    Multidrug-resistant phenotypes in Gram-negative bacteria such as Escherichia coli mainly result from overexpression of the AcrAB-TolC efflux pump. Efflux pump inhibitors may be obtained from plant extracts, such as alkaloid extract of Sophora spp. The aims of this study were to evaluate the antibacterial and anti-pump potential of local Sophora alopecuroides total alkaloid extract and commercial matrine in combination with ciprofloxacin in highly resistant E. coli clones. Alkaloid extract of S. alopecuroides seeds was prepared by acid-base solution and chloroform extraction. The percentage of matrine in this extract was measured by high-performance liquid chromatography (HPLC). Minimum inhibitory concentrations (MICs) of the extract and matrine in combination with ciprofloxacin were determined by the microbroth dilution method. The anti-pump activity of these combined materials was measured by ciprofloxacin accumulation assay and real-time PCR. The alkaloid extract contained 31.2% matrine. A synergistic interaction [fractional inhibitory concentration index (FICI)=0.13] was seen between the extract (1.56mg/mL) and ciprofloxacin (1μg/mL) in highly resistant E. coli clones. A significant decrease (Pextract or matrine for 36h. Accumulation of ciprofloxacin enhanced 2.8- and 2-fold following addition of matrine and plant extract, respectively, in these clones. Alkaloid extract of local S. alopecuroides and matrine have anti-pump activity; further investigations are necessary to elucidate their exact mechanisms of action. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

  8. A Simple Technique for High Resistance Measurement

    Science.gov (United States)

    Aguilar, Horacio Munguia; Landin, Ramon Ochoa

    2012-01-01

    A simple electronic system for the measurement of high values of resistance is shown. This system allows the measurement of resistance in the range of a few megohm up to 10[superscript 9] [omega]. We have used this system for the evaluation of CdS thin film resistance, but other practical uses in the basic physics laboratory are presented.…

  9. Control of residual carbon concentration in GaN high electron mobility transistor and realization of high-resistance GaN grown by metal-organic chemical vapor deposition

    Energy Technology Data Exchange (ETDEWEB)

    He, X.G. [State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083 (China); Zhao, D.G., E-mail: dgzhao@red.semi.ac.cn [State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083 (China); Jiang, D.S.; Liu, Z.S.; Chen, P.; Le, L.C.; Yang, J.; Li, X.J. [State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083 (China); Zhang, S.M.; Zhu, J.J.; Wang, H.; Yang, H. [Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215125 (China)

    2014-08-01

    GaN films were grown by metal-organic chemical vapor deposition (MOCVD) under various growth conditions. The influences of MOCVD growth parameters, i.e., growth pressure, ammonia (NH{sub 3}) flux, growth temperature, trimethyl-gallium flux and H{sub 2} flux, on residual carbon concentration ([C]) were systematically investigated. Secondary ion mass spectroscopy measurements show that [C] can be effectively modulated by growth conditions. Especially, it can increase by reducing growth pressure up to two orders of magnitude. High-resistance (HR) GaN epilayer with a resistivity over 1.0 × 10{sup 9} Ω·cm is achieved by reducing growth pressure. The mechanism of the formation of HR GaN epilayer is discussed. An Al{sub x}Ga{sub 1−x}N/GaN high electron mobility transistor structure with a HR GaN buffer layer and an additional low-carbon GaN channel layer is presented, exhibiting a high two dimensional electron gas mobility of 1815 cm{sup 2}/Vs. - Highlights: • Influence of MOCVD parameters on residual carbon concentration in GaN is studied. • GaN layer with a resistivity over 1 × 10{sup 9} Ω·cm is achieved by reducing growth pressure. • High electron mobility transistor (HEMT) structures were prepared. • Control of residual carbon content results in HEMT with high 2-D electron gas mobility.

  10. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool

    Directory of Open Access Journals (Sweden)

    Denish Calmax Angol

    2017-01-01

    Full Text Available Background. Around 70–90% of peptic ulcer disease (PUD is due to Helicobacter pylori and requires treatment with antimicrobials to which these bacteria are susceptible. Common H. pylori diagnostic tests do not provide drug susceptibility data. Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous detection of H. pylori and its resistance to clarithromycin (CLA/fluoroquinolones (FLQ, we present evidence for stool as an optional test specimen and also provide data on prevalence of H. pylori resistance to CLA and FLQ in Uganda. Methods. Stool from 142 symptomatic PUD patients at three hospitals in Kampala was screened for H. pylori using a rapid antigen test. The GenoType HelicoDR test was run on all H. pylori antigen positives to determine PCR positivity and resistance to CLA/FLQ. Results. Thirty-one samples (22% were H. pylori antigen positive, and 21 (68% of these were H. pylori PCR positive. Six of the 21 (29% were resistant to CLA and eight to FLQ (42%, while two gave invalid FLQ resistance results. Conclusion. Stool is a possible specimen for the GenoType HelicoDR test for rapid detection of H. pylori and drug resistance. In Uganda, Helicobacter pylori is highly resistant to CLA and FLQ.

  11. Beam test results of CMS RPCs at high eta region under high-radiation environment

    CERN Document Server

    Park, S; Bahk, S Y; Hong, B; Hong, S J; Kang, D H; Kang, T I; Kim, T J; Kim, Y J; Kim, Y U; Koo, D G; Lee, H W; Lee, K S; Lee, S J; Lim, J K; Moon, D H; Nam, S K; Oh, J K; Park, W J; Rhee, J T; Ryu, M S; Shim, H H; Sim, K S

    2004-01-01

    The Compact Muon Solenoid (CMS) forward resistivity plate chambers (RPCs) at the high eta region must be operated in presence of a radiation-induced rate as high as 1 kHz/cm**2. It is still unknown if the RPCs coated with linseed oil can be operated under such a high- radiation environment over the lifetime of CMS. Non-oiled RPCs may be one of the options since phenolic or melamine-coated bakelite is chemically stabler than linseed oil. We have constructed oiled and non-oiled RPCs at the high eta region of CMS using phenolic bakelite and tested them in the Gamma Irradiation Facility at CERN. While both RPCs show the same characteristics in the efficiency and the strip multiplicity, the non-oiled RPC generates an intrinsic noise rate of 50 Hz/cm**2, compared to only 5 Hz/cm**2 for the oiled RPC, both at 10.0kV which is about 100 V above the 95% knee of the efficiency curve.

  12. Performance of a large forward resistive plate chamber for the CMS /LHC under high radiation environment

    CERN Document Server

    Ahn, S H; Bahk, S Y; Hong, B; Hong, S J; Kim, K H; Kim, Y J; Kim, Y U; Koo, D G; Lee, K S; Lee, S J; Nam, S K; Park, S; Rhee, J T; Seo, S W; Sim, K S

    2001-01-01

    We present the first beam test results of a real size prototype RPC for the endcap region of the CMS, one of large detectors at CERN LHC. The chamber was built with relatively low resistivity bakelite made in Korea and was operated successfully at the Gamma Irradiation Facility at CERN under the highest photon flux available, which corresponds to an effective cluster rate up to about 800 Hz/cm/sup 2 /. The cross-talk effects between strips and sectors have been studied extensively. The high voltage plateau, which satisfies the CMS requirements for efficiency and the number of strips fired per cluster, extends to at least 300 V. The time resolution has been measured to be better than 1.3 ns in this HV plateau region. These results demonstrate that the current design of the device can be used as a muon trigger detector for the CMS forward region. (13 refs).

  13. Use of the longitudinal Pickle's effect in the measure of the electro- and photo-conductivity of crystals of sillenite and with high resistivity; Utilizacion del efecto Pockels longitudinal en la medicion de la electro y fotoconductividad de cristales de silenita impurificados y con alta resistividad

    Energy Technology Data Exchange (ETDEWEB)

    Ilinskii, A. V.; Silva-Andrade, F.; Chavez, F.; Banuelos, F.; Prutskij, T. A. [Benemerita Universidad Autonoma de Puebla, Puebla (Mexico)

    2001-06-01

    Using the electro-optic longitudinal effect we have measured the electro- and photo-conductivity in photorefractive sillenite crystals with high resistivity. We have studied doped samples with aluminium, chromium, vanadium, cobalt, iron, and neodymium impurities distributed in the bulk or in a thin region near the surface. The data of the electro-optical measurements has been completed with the spectra of optical absorption in the investigated samples. [Spanish] Empleando el efecto electrooptico longitudinal se ha medido la electro y la fotoconductividad en cristales fotorrefractivos de silenita con alta resistividad. Se han estudiado muestras impurificadas con Al, Cr, V, Co, Fe y Nd distribuidas en todo el volumen o en una region delgada cerca de la superficie. Los datos de la medicion electroptica se han complementado con los espectros de absorcion optica en las muestras investigadas.

  14. A proposal to upgrade the ATLAS RPC system for the High Luminosity LHC

    CERN Document Server

    ATLAS Collaboration; The ATLAS collaboration

    2015-01-01

    The architecture of the present trigger system in the ATLAS Muon Barrel was designed according to a reference luminosity of 10^34 cm-2 s-1 with a safety factor of 5, with respect to the simulated background rates, now confirmed by LHC Run-1 data. HL-LHC will provide a luminosity 5 times higher and an order of magnitude higher background. As a result, the performance demand increases, while the detector being susceptible to ageing effects. Moreover, the present muon trigger acceptance in the barrel is just above 70%, due to the presence of the barrel toroid structures. This scenario induced the ATLAS muon Collaboration to propose an appropriate upgrade plan, involving both detector and trigger-readout electronics, to guarantee the performance required by the physics program for the 20 years scheduled. This consists in installing a layer of new generation RPCs in the inner barrel, to increase the redundancy, the selectivity, and provide almost full acceptance. The first 10% of the system, corresponding to the e...

  15. Toward a RPC-based muon tomography system for cargo containers.

    Science.gov (United States)

    Baesso, P.; Cussans, D.; Thomay, C.; Velthuis, J.

    2014-10-01

    A large area scanner for cosmic muon tomography is currently being developed at University of Bristol. Thanks to their abundance and penetrating power, cosmic muons have been suggested as ideal candidates to scan large containers in search of special nuclear materials, which are characterized by high-Z and high density. The feasibility of such a scanner heavily depends on the detectors used to track the muons: for a typical container, the minimum required sensitive area is of the order of 100 2. The spatial resolution required depends on the geometrical configuration of the detectors. For practical purposes, a resolution of the order of 1 mm or better is desirable. A good time resolution can be exploited to provide momentum information: a resolution of the order of nanoseconds can be used to separate sub-GeV muons from muons with higher energies. Resistive plate chambers have a low cost per unit area and good spatial and time resolution; these features make them an excellent choice as detectors for muon tomography. In order to instrument a large area demonstrator we have produced 25 new readout boards and 30 glass RPCs. The RPCs measure 1800 mm× 600 mm and are read out using 1.68 mm pitch copper strips. The chambers were tested with a standardized procedure, i.e. without optimizing the working parameters to take into account differences in the manufacturing process, and the results show that the RPCs have an efficiency between 87% and 95%. The readout electronics show a signal to noise ratio greater than 20 for minimum ionizing particles. Spatial resolution better than 500 μm can easily be achieved using commercial read out ASICs. These results are better than the original minimum requirements to pass the tests and we are now ready to install the detectors.

  16. Development of a large-area Multigap RPC with adequate spatial resolution for muon tomography

    Science.gov (United States)

    Wang, J.; Wang, Y.; Wang, X.; Zeng, M.; Xie, B.; Han, D.; Lyu, P.; Wang, F.; Li, Y.

    2016-11-01

    We study the performance of a large-area 2-D Multigap Resistive Plate Chamber (MRPC) designed for muon tomography with high spatial resolution. An efficiency up to 98% and a spatial resolution of around 270 μ m are obtained in cosmic ray and X-ray tests. The performance of the MRPC is also investigated for two working gases: standard gas and pure Freon. The result shows that the MRPC working in pure Freon can provide higher efficiency and better spatial resolution.

  17. The multigap RPC detector and the ALICE time-of-flight

    CERN Document Server

    Zichichi, A

    2003-01-01

    One of the new detectors invented within the LAA project is the Multigap Resistive Plate Chamber (MRPC). The MRPC has been selected as the Time-of-Flight detector of choice for the ALICE experiment. The R and D program to optimise the MRPC for this application has now been completed, resulting in a device with 10 gas gaps of 250 mu m in width; a summary is given in this paper. Concerning the front-end electronics, there is an on-going development of an ASIC using 0.25 micron CMOS; the excellent performance of the ASIC is evident from the initial tests; some results will be shown here. Finally the timing properties of this detector open up other applications such as for Positron Electron Tomography. (author)

  18. Validation of the new filters configuration for the RPC gas systems at LHC experiments

    CERN Document Server

    Mandelli, Beatrice; Guida, Roberto; Hahn, Ferdinand; Haider, Stefan

    2012-01-01

    Resistive Plate Chambers (RPCs) are widely employed as muon trigger systems at the Large Hadron Collider (LHC) experiments. Their large detector volume and the use of a relatively expensive gas mixture make a closed-loop gas circulation unavoidable. The return gas of RPCs operated in conditions similar to the experimental background foreseen at LHC contains large amount of impurities potentially dangerous for long-term operation. Several gas-cleaning agents, characterized during the past years, are currently in use. New test allowed understanding of the properties and performance of a large number of purifiers. On that basis, an optimal combination of different filters consisting of Molecular Sieve (MS) 5Å and 4Å, and a Cu catalyst R11 has been chosen and validated irradiating a set of RPCs at the CERN Gamma Irradiation Facility (GIF) for several years. A very important feature of this new configuration is the increase of the cycle duration for each purifier, which results in better system stabilit...

  19. Current Challenges and Perspectives in Resistive Gaseous Detectors: a manifesto from RPC 2012

    CERN Document Server

    Gonzalez-Diaz, Diego

    2012-01-01

    Resistive gaseous detectors can be broadly defined as those operated in conditions where virtually no field lines exist that connect any two metallic electrodes sitting at different potential. This condition can be operationally recognized as 'no gas gap being delimited by two metallic electrodes'. Since early 70's, Resistive Plate Chambers (RPCs) are the most successful implementation of this idea, that leads to fully spark-protected gaseous detectors, with solid state-like reliability at working fields beyond 100kV/cm, yet enjoying the general characteristics of gaseous detectors in terms of flexibility, optimization and customization. We present a summary of the status of the field of resistive gaseous detectors as discussed in a dedicated closing session that took place during the XI Workshop for Resistive Plate Chambers and Related Detectors celebrated in Frascati, and especially we review the perspectives and ambitions towards the XII Workshop to be celebrated in Beijing in year 2014. Due to the existen...

  20. Simulation of RPC performance for 511 keV photon detection

    CERN Document Server

    Lippmann, C; Riegler, W

    2009-01-01

    Measurements of the time resolution of timing Resistive Plate Chambers (RPCs) reveal some differences when comparing the results for 511 keV photons and for particle beams. The subject is of interest, since timing RPCs are currently considered for Positron Emission Tomography (PET), where the sensitivity of the system depends largely on the time resolution of the detector. In this publication we discuss possible explanations, in particular the statistical fluctuations of the deposited charge and the Compton electron flight time distributions. Moreover, we rediscuss the reduction of the Townsend coefficient due to the space charge effect inside the avalanches as a function of the avalanche size. We shall see that the dependence assumed by different analytic models differs significantly from what is predicted by detailed Monte Carlo avalanche simulations.

  1. Automatic relative RPC image model bias compensation through hierarchical image matching for improving DEM quality

    Science.gov (United States)

    Noh, Myoung-Jong; Howat, Ian M.

    2018-02-01

    The quality and efficiency of automated Digital Elevation Model (DEM) extraction from stereoscopic satellite imagery is critically dependent on the accuracy of the sensor model used for co-locating pixels between stereo-pair images. In the absence of ground control or manual tie point selection, errors in the sensor models must be compensated with increased matching search-spaces, increasing both the computation time and the likelihood of spurious matches. Here we present an algorithm for automatically determining and compensating the relative bias in Rational Polynomial Coefficients (RPCs) between stereo-pairs utilizing hierarchical, sub-pixel image matching in object space. We demonstrate the algorithm using a suite of image stereo-pairs from multiple satellites over a range stereo-photogrammetrically challenging polar terrains. Besides providing a validation of the effectiveness of the algorithm for improving DEM quality, experiments with prescribed sensor model errors yield insight into the dependence of DEM characteristics and quality on relative sensor model bias. This algorithm is included in the Surface Extraction through TIN-based Search-space Minimization (SETSM) DEM extraction software package, which is the primary software used for the U.S. National Science Foundation ArcticDEM and Reference Elevation Model of Antarctica (REMA) products.

  2. Offline Data Quality Monitoring for the RPC of the CMS Detector

    CERN Document Server

    Fabela Enriquez, Brenda

    2016-01-01

    Data Quality Monitoring is an important activity that guarantees the proper operation of the detectors in high energy experiments. Besides of the online environment for data quality monitoring there is an offline environment which main goal is the reconstruction and validation of the calibration results, software releases and simulated data. The offline monitoring system of the Resistive Plate Chambers at the Muon Detector of the CMS consists on the data analysis of each run in order to verify that all the subsystems are working correctly, at an efficiency greater than 95pct. This work presents the latest upgrade done to the offline monitoring software based on the restyling of the efficiency code for the 2016 data taking that is about to start. This update allows to do the general analysis in less time in a more complete way and makes the code more flexible to do specific analysis.

  3. Optimization, Synchronization, Calibration and Diagnostic of the RPC PAC Muon Trigger System for the CMS detector

    CERN Document Server

    Bunkowski, Karol

    2009-01-01

    The Compact Muon Solenoid is one of the four experiments that will analyse the results of the collisions of the protons accelerated by the Large Hadron Collider (LHC). The collisions of proton bunches occur in the middle of the CMS detector every 25 ns, i.e. with a frequency of 40 MHz. Such a high collision frequency is needed because the probability of interesting processes, which we hope to discover at the LHC (such as production of Higgs bosons or supersymmetric particles) is very small. The objects that are the results of the proton-proton collisions are detected and measured by the CMS detector. Out of each bunch crossing the CMS produces about 1 MB of data; 40 millions of bunch collisions per second give the data stream of 40 terabytes (1013) per second. Such a stream of data is practically not possible to record on mass storage, therefore the first stage of the analysis of the detector data is performed in real time by the dedicated trigger system. Its task is to select potentially interesting events (...

  4. Biochemical basis of the high resistance to oxidative stress in ...

    Indian Academy of Sciences (India)

    Apoptosis; D. discoideum; oxidative stress; antioxidant enzymes; lipid peroxidation ... Dose-dependent induction of cell death by exogenous addition of hydrogen peroxide (H2O2), in situ generation of H2O2 by hydroxylamine, and nitric oxide (NO) generation by sodium nitroprusside treatment in D. discoideum were studied.

  5. Radiolucent Composites Providing High Resistance against Sterilization Decomposition

    Czech Academy of Sciences Publication Activity Database

    Suchý, Tomáš; Balík, Karel; Sedláček, R.; Sucharda, Zbyněk; Sochor, M.; Prokop, J.; Beneš, J.; Křena, J.

    2011-01-01

    Roč. 55, č. 4 (2011), s. 401-409 ISSN 0862-5468 R&D Projects: GA ČR(CZ) GAP108/10/1457 Institutional research plan: CEZ:AV0Z30460519 Keywords : composite material * polymer matrix * radiolucency Subject RIV: JI - Composite Materials Impact factor: 0.382, year: 2011 http://www.ceramics-silikaty.cz/2011/2011_04_401.htm

  6. Effect of cobalt-60 {gamma} radiation and of thermal neutrons on high resistance P and N silicon. Possibility of obtaining a nuclear compensation for P type silicon; Effects du rayonnement {gamma} du cobalt 60 et de neutrons thermiques sur du silicium P et N de haute resistivite. Possibilite de realiser une compensation nucleaire d'un silicium du type P

    Energy Technology Data Exchange (ETDEWEB)

    Messier, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-11-01

    Type P silicon has been compensated by the production of a controlled and uniform amount of donor atoms ({sup 31}P) using thermal neutrons to bring about a nuclear transformation. It is shown that it is possible in this way to reduce by a factor of about one hundred the overall concentration of residual ionised impurities in the purest crystals obtained by floating zone purification (2 x 10{sup 12} atoms/cm{sup 3}). The degree compensation obtained is limited by the initial inhomogeneity of acceptor impurities which have to be compensated. Lattice defects which still remain after prolonged annealings reduce the life-time of the material to about 10 {mu}s approximately. Particle detectors having thicknesses of 2 to 5 mm have been built by this process; they give good results, particularly at low temperatures. A study has also been made of the number and of the nature of lattice defects produced by thermal neutrons in high resistivity P and N type crystals. These defects have been compared to those produced by {gamma} rays from {sup 60}Co. A discussion is given of the validity of the Wertheim model concerning pronounced recombination at low temperatures (77 deg. K - 300 deg. K) of primary defect-interstitial pairs. The nature of the defects introducing energy levels into the lower half of the forbidden band has been studied. (author) [French] On a compense du silicium de type P en produisant, au moyen de neutrons thermiques, par transmutation nucleaire une quantite controlee et uniforme d'atomes donneurs ({sup 31}P). On montre qu'on peut ainsi reduire de cent fois environ la densite nette d'impuretes ionisees residuelles subsistant dans les cristaux les plus purs obtenus par purification par zone flottante (2.10{sup 12} atomes/cm{sup 3}). Le degre de compensation obtenu est limite par i'inhomogeneite initiale des impuretes acceptrices a compenser. Des defauts de reseau qui subsistent meme apres des recuits prolonges reduisent la duree de vie du

  7. A readout digitization system for the ATLAS muon spectrometer phase-I tRPC trigger upgrade

    Science.gov (United States)

    Meng, X. T.; Levin, D. S.; Chapman, J. W.; Li, D. C.; Yao, Z. E.; Zhou, B.

    2017-10-01

    The front-end digitization electronics for thin-Resistive Plate Chambers to be installed as part of the ATLAS Muon Spectrometer Phase-I upgrade project is described. The design is based on the CERN HPTDC and GOL chips. In this paper, the design of the digitization system is presented, including power, connection interfaces to front-end amplifier-shaper-discriminator board and to the low level trigger processor board. System performance tests were conducted and validated with a prototype which includes one HPTDC/GOL pair.

  8. A Simulation of the Front End Signal Digitization for the ATLAS Muon Spectrometer thin RPC trigger upgrade project

    Science.gov (United States)

    Meng, Xiangting; Chapman, John; Levin, Daniel; Dai, Tiesheng; Zhu, Junjie; Zhou, Bing; Um Atlas Group Team

    2016-03-01

    The ATLAS Muon Spectrometer Phase-I (and Phase-II) upgrade includes the BIS78 muon trigger detector project: two sets of eight very thin Resistive Place Chambers (tRPCs) combined with small Monitored Drift Tube (MDT) chambers in the pseudorapidity region 1Digitization of the strip signals will be done by 32-channel CERN HPTDC chips. The HPTDC is a highly configurable ASIC designed by the CERN Microelectronics group. It can work in both trigger and trigger-less modes, be readout in parallel or serially. For Phase-I operation, a stringent latency requirement of 43 bunch crossings (1075 ns) is imposed. The latency budget for the front end digitization must be kept to a minimal value, ideally less than 350 ns. We conducted detailed HPTDC latency simulations using the Behavioral Verilog code from the CERN group. We will report the results of these simulations run for the anticipated detector operating environment and for various HPTDC configurations.

  9. Emergence of NDM-1-positive capsulated Escherichia coli with high resistance to serum killing in Japan.

    Science.gov (United States)

    Yamamoto, Tatsuo; Takano, Tomomi; Iwao, Yasuhisa; Hishinuma, Akira

    2011-06-01

    The New Delhi metallo-β-lactamase-1 (NDM-1) gene, bla (NDM-1), is an emerging plasmid-borne drug resistance gene, which encodes for exceptionally broad-spectrum β-lactamase, being able to hydrolyze a wide variety of β-lactams, including carbapenems, and was first reported in Klebsiella pneumoniae from a Swedish patient of Indian origin in 2009. It is widely distributed among Enterobacteriacae and has geographically exhibited extremely rapid and global spread. In this study, we characterized the bla (NDM-1)-positive ST38 Escherichia coli strain NDM-1 Dok01 (which was isolated from the blood of a 54-year-old Japanese inpatient, who had previously visited India), focusing on bacterial surface structures related to virulence. The E. coli culture contained colony variants, which developed a transparent smooth colony and a rough colony on blood agar plates. The smooth colony-forming cells (substrain M1) possessed a surface capsule and were resistant to serum killing, whereas rough colony-forming mutants (substrain B2) lacked a capsule (and a 5.3-kb plasmid) and were highly susceptible to serum killing. Reflecting the surface structural difference, substrain M1 was more flagellated and motile, whereas substrain B2 was less flagellated and apparently possessed straight pili 5 nm wide, which played a role in adherence to human intestinal cells and bacterial autoaggregation. Data suggest that the bla (NDM-1)-positive ST38 E. coli has emerged in Japan and that it is a capsulated bacterial pathogen with virulence potential in the blood stream.

  10. Molecular detection of an atypical, highly resistant, clonal Pseudomonas aeruginosa isolate in cystic fibrosis patients.

    LENUS (Irish Health Repository)

    Keating, Deirdre

    2013-03-01

    The identification of Pseudomonas aeruginosa (P. aeruginosa) isolates in sputum from cystic fibrosis (CF) patients can be challenging due to the multitude of phenotypic changes isolates undergo during adaptation to the microenvironment of the CF lung.

  11. Optical and electrical characterization of high resistivity semiconductors for constant-bias microbolometer devices

    Science.gov (United States)

    Saint John, David B.

    The commercial market for uncooled infrared imaging devices has expanded in the last several decades, following the declassification of pulse-biased microbolometer-based focal plane arrays (FPAs) using vanadium oxide as the sensing material. In addition to uncooled imaging platforms based on vanadium oxide, several constant-bias microbolometer FPAs have been developed using doped hydrogenated amorphous silicon (a-Si:H) as the active sensing material. While a-Si:H and the broader Si1-xGex:H system have been studied within the context of photovoltaic (PV) devices, only recently have these materials been studied with the purpose of qualifying and optimizing them for potential use in microbolometer applications, which demand thinner films deposited onto substrates different than those used in PV. The behavior of Ge:H is of particular interest for microbolometers due to its intrinsically low resistivity without the introduction of dopants, which alter the growth behavior and frustrate any attempt to address the merits of protocrystalline a-Ge:H. This work reports the optical, microstructural, and electrical characterization and qualification of a variety of Si:H, Si1-xGex:H, and Ge:H films deposited using a plasma enhanced chemical vapor deposition (PECVD) process, including a-Ge:H films which exhibit high TCR (4-6 -%/K) and low 1/f noise at resistivities of interest for microbolometers (4000 -- 6000 O cm). Thin film deposition has been performed simultaneously with real-time optical characterization of the growth evolution dynamics, providing measurement of optical properties and surface roughness evolutions relevant to controlling the growth process for deliberate variations in film microstructure. Infrared spectroscopic ellipsometry has been used to characterize the Si-H and Ge-H absorption modes allowing assessment of the hydrogen content and local bonding behavior in thinner films than measured traditionally. This method allows IR absorption analysis of hydrogen bonding and other IR modes to be extended to arbitrary substrates, including absorbing and/or device-like substrate configurations not amenable to traditional methods of assessing hydrogen related absorption using infrared transmission measurements. In addition to novel optical assessments of hydrogen in Si1-xGe x:H films, the role of carrier type in a-Si:H has been studied, with n-type material providing a consistently higher TCR and 1/f noise character than p-type material for films of similar resistivity. As the introduction of dopant gas complicates microstructural growth, assessment of undoped material was performed, finding that only Ge-rich films possess suitable resitivities for electrical measurement. The inclusion of nanocrystalline material into otherwise amorphous films has been explored in both Si:H and Ge:H, finding that decreases in resistivity and TCR were not accompanied by a decrease in the 1/f noise character. This suggests that mixed (a+nc) Si1-xGex:H material may be less suitable for microbolometer applications than optimized amorphous material.

  12. Tungsten oxide thin films grown by thermal evaporation with high resistance to leaching

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Diogo S. [Universidade Federal de Pelotas (UFPel), RS (Brazil). Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos; Pazinato, Julia C.O.; Freitas, Mauricio A. de; Radtke, Claudio; Garcia, Irene T.S., E-mail: irene@iq.ufrgs.br [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Instituto de Quimica; Dorneles, Lucio S. [Universidade Federal de Santa Maria (UFSM), RS (Brazil). Centro de Ciencias Naturais e Exatas

    2014-05-15

    Tungsten oxides show different stoichiometries, crystal lattices and morphologies. These characteristics are important mainly when they are used as photocatalysts. In this work tungsten oxide thin films were obtained by thermal evaporation on (100) silicon substrates covered with gold and heated at 350 and 600 °C, with different deposition times. The stoichiometry of the films, morphology, crystal structure and resistance to leaching were characterized through X-ray photoelectron spectroscopy, micro-Raman spectroscopy, scanning and transmission electron microscopy, X-ray diffractometry, Rutherford backscattering spectrometry and O{sup 16} (α,α')O{sup 16} resonant nuclear reaction. Films obtained at higher temperatures show well-defined spherical nanometric structure; they are composed of WO{sub 3.1} and the presence of hydrated tungsten oxide was also observed. The major crystal structure observed is the hexagonal. Thin films obtained through thermal evaporation present resistance to leaching in aqueous media and excellent performance as photocatalysts, evaluated through the degradation of the methyl orange dye. (author)

  13. Tolerance to various toxicants by marine bacteria highly resistant to mercury

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.; Mesquita, A.; Verlecar, X.N.

    in environmental pollution bioremediation. The mercury-resistant bacteria were found to belong to Pseudomonas, Proteus, Xanthomonas, Alteromonas, Aeromonas, and Enterobacteriaceae. All these environmental bacterial strains tolerant to mercury used in this study...

  14. Studying boundary elements’ behaviour using masonry walls built with high-resistance bricks

    Directory of Open Access Journals (Sweden)

    Juan Carlos Restrepo Mejía

    2010-04-01

    Full Text Available This research was aimed at studying the behaviour of masonry walls built with and without boundary elements at both ends when sublected to monotonic and cyclic lateral loads. The walls were designed to have the greatest resistance, following NSR-98 recommendations (normas Colombianas de diseno y construcción sismo resistente, except for shear reinforcement. XTRACT software was used for finding axial load cf bending moment and curvature cf bending moment curves. One monotonic test and two cyclic tests were performed for each type of wall. Experimental results from the walls’ lateral load cf displacement curves were used for determining their ability to dissipate energy on an inelastic range (“R” force-reduction factor for seismic loads and displacement and curvature malleability. It was found that walls built without boundary elements suffered shear failure with cracks in a stepped configuration along the bricks’ edge. The type of failure for walls built with boundary elements was shear failure in the central panel with cracks in a stepped configuration, in addition to compression failure at the edge of the boundary elements with vertical cracks on the lower part of the wall and at the contact between the wall and the boundary element. Comparison with two other studies carried out at the Universidad Nacional showed similar cyclic behaviour, regardless of the clay brick’s strength. The “R” values obtained for both types of walls were lower than the recommended values given by NSR-98. It was determined that walls having boundary element have greater displacement malleability than walls without boundary elements.

  15. High resistivity iron-based, thermally stable magnetic material for on-chip integrated inductors

    Science.gov (United States)

    Deligianni, Hariklia; Gallagher, William J.; Mason, Maurice; O'Sullivan, Eugene J.; Romankiw, Lubomyr T.; Wang, Naigang

    2017-03-07

    An on-chip magnetic structure includes a palladium activated seed layer and a substantially amorphous magnetic material disposed onto the palladium activated seed layer. The substantially amorphous magnetic material includes nickel in a range from about 50 to about 80 atomic % (at. %) based on the total number of atoms of the magnetic material, iron in a range from about 10 to about 50 at. % based on the total number of atoms of the magnetic material, and phosphorous in a range from about 0.1 to about 30 at. % based on the total number of atoms of the magnetic material. The magnetic material can include boron in a range from about 0.1 to about 5 at. % based on the total number of atoms of the magnetic material.

  16. Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut.

    Science.gov (United States)

    Allen, Aron; Islamovic, Emir; Kaur, Jagdeep; Gold, Scott; Shah, Dilip; Smith, Thomas J

    2011-10-01

    The corn smut fungus, Ustilago maydis, is a global pathogen responsible for extensive agricultural losses. Control of corn smut using traditional breeding has met with limited success because natural resistance to U. maydis is organ specific and involves numerous maize genes. Here, we present a transgenic approach by constitutively expressing the Totivirus antifungal protein KP4, in maize. Transgenic maize plants expressed high levels of KP4 with no apparent negative impact on plant development and displayed robust resistance to U. maydis challenges to both the stem and ear tissues in the greenhouse. More broadly, these results demonstrate that a high level of organ independent fungal resistance can be afforded by transgenic expression of this family of antifungal proteins. © 2011 The Authors. Plant Biotechnology Journal © 2011 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd.

  17. Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

    Science.gov (United States)

    Arranz, Lorena; Naudí, Alba; De la Fuente, Mónica; Pamplona, Reinald

    2013-06-01

    Membrane unsaturation plays an important role in the aging process and the determination of inter-species animal longevity. Furthermore, the accumulation of oxidation-derived molecular damage to cellular components particularly in the nervous and immune systems over time leads to homeostasis loss, which highly influences age-related morbidity and mortality. In this context, it is of great interest to know and discern the degree of membrane unsaturation and the steady-state levels of oxidative damage in both physiological systems from long-lived subjects. In the present work, adult (28 ± 4 weeks), old (76 ± 4 weeks) and exceptionally old (128 ± 4 weeks) BALB/c female mice were used. Brain and spleen were analysed for membrane fatty acid composition and specific markers of protein oxidation, glycoxidation and lipoxidation damage, i.e. glutamic semialdehyde, aminoadipic semialdehyde, carboxyethyl-lysine, carboxymethyl-lysine and malondialdehyde-lysine, by gas chromatography-mass spectrometry. The results showed significantly lower peroxidizability index in brain and spleen from exceptionally old animals when compared to old specimens. The higher membrane resistance to lipid peroxidation and lower lipoxidation-derived molecular damage found in exceptionally old animals was associated with a significantly lower desaturase activity and peroxisomal β-oxidation. Protein oxidation markers in brain and spleen from adult and exceptionally old animals showed similar levels, which were higher in old mice. In addition, the higher levels of the glycoxidation-derived marker observed in exceptionally old animals, as well as in adult mice, could be considered as a good indicator of a better bioenergetic state of these animals when compared to the old group. In conclusion, low lipid oxidation susceptibility and maintenance of adult-like protein lipoxidative damage could be key mechanisms for longevity achievement.

  18. High resistivity iron-based, thermally stable magnetic material for on-chip integrated inductors

    Energy Technology Data Exchange (ETDEWEB)

    Deligianni, Hariklia; Gallagher, William J.; Mason, Maurice; O' Sullivan, Eugene J.; Romankiw, Lubomyr T.; Wang, Naigang

    2017-10-17

    An on-chip magnetic structure includes a palladium activated seed layer and a substantially amorphous magnetic material disposed onto the palladium activated seed layer. The substantially amorphous magnetic material includes nickel in a range from about 50 to about 80 atomic % (at. %) based on the total number of atoms of the magnetic material, iron in a range from about 10 to about 50 at. % based on the total number of atoms of the magnetic material, and phosphorous in a range from about 0.1 to about 30 at. % based on the total number of atoms of the magnetic material. The magnetic material can include boron in a range from about 0.1 to about 5 at. % based on the total number of atoms of the magnetic material.

  19. Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates.

    Science.gov (United States)

    Baranyai, Zsuzsa; Krátký, Martin; Vinšová, Jarmila; Szabó, Nóra; Senoner, Zsuzsanna; Horváti, Kata; Stolaříková, Jiřina; Dávid, Sándor; Bősze, Szilvia

    2015-08-28

    In the Mycobacterium genus over one hundred species are already described and new ones are periodically reported. Species that form colonies in a week are classified as rapid growers, those requiring longer periods (up to three months) are the mostly pathogenic slow growers. More recently, new emerging species have been identified to lengthen the list, all rapid growers. Of these, Mycobacterium abscessus is also an intracellular pathogen and it is the most chemotherapy-resistant rapid-growing mycobacterium. In addition, the cases of multidrug-resistant Mycobacterium tuberculosis infection are also increasing. Therefore there is an urgent need to find new active molecules against these threatening strains. Based on previous results, a series of salicylanilides, salicylanilide 5-chloropyrazinoates and carbamates was designed, synthesized and characterised. The compounds were evaluated for their in vitro activity on M. abscessus, susceptible M. tuberculosis H37Rv, multidrug-resistant (MDR) M. tuberculosis MDR A8, M. tuberculosis MDR 9449/2006 and on the extremely-resistant Praha 131 (XDR) strains. All derivatives exhibited a significant activity with minimum inhibitory concentrations (MICs) in the low micromolar range. Eight salicylanilide carbamates and two salicylanilide esters exhibited an excellent in vitro activity on M. abscessus with MICs from 0.2 to 2.1 μM, thus being more effective than ciprofloxacin and gentamicin. This finding is potentially promising, particularly, as M. abscessus is a threateningly chemotherapy-resistant species. M. tuberculosis H37Rv was inhibited with MICs from 0.2 μM, and eleven compounds have lower MICs than isoniazid. Salicylanilide esters and carbamates were found that they were effective also on MDR and XDR M. tuberculosis strains with MICs ≥1.0 μM. The in vitro cytotoxicity (IC50) was also determined on human MonoMac-6 cells, and selectivity index (SI) of the compounds was established. In general, salicylanilide derivatives substituted by halogens on both salicyl and aniline rings showed better activity, than 4-benzoylaniline derivatives. The ester or carbamate bond formation of parent salicylanilides mostly retained or improved antimycobacterial potency with moderate selectivity. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. High resistance to sulfur poisoning of Ni with copper skin under electric field

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xiaopei; Zhang, Yanxing [College of Physics and Materials Science, Henan Normal University, Xinxiang, Henan 453007 (China); Yang, Zongxian, E-mail: yzx@henannu.edu.cn [College of Physics and Materials Science, Henan Normal University, Xinxiang, Henan 453007 (China); Collaborative Innovation Center of Nano Functional Materials and Applications, Kaifeng, Henan Province (China)

    2017-02-12

    The effects of sulfur poisoning on the (1 0 0), (1 1 0) and (1 1 1) surfaces of pure Ni and Cu/Ni alloy are studied in consideration of the effect of electric field. The effects of Cu dopants on the S poisoning characteristics are analyzed by the means of the density functional theory results in combination with thermodynamics data using the ab initio atomistic thermodynamic method. When the Cu concentration increases to 50% on the surface layer of the Cu/Ni alloy, the (1 1 0) surface becomes the most vulnerable to the sulfur poisoning. Ni with a copper skin can mostly decrease the sulfur poisoning effect. Especially under the electric field of 1.0 V/Å, the sulfur adsorption and phase transition temperature can be further reduced. We therefore propose that Ni surfaces with copper skin can be very effective to improve the resistance to sulfur poisoning of the Ni anode under high electric field. - Highlights: • The electric field and Cu dopant effects on S poisoning feature of Ni are analyzed. • The present of large electric field can enhance S tolerance. • Cu dopant concentration affect the surface electronic structure of Ni. • 100% Cu doping on surface Ni layer can mostly decrease the sulfur poison.

  1. Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells.

    Directory of Open Access Journals (Sweden)

    Omar M El-Halfawy

    Full Text Available The overall antibiotic resistance of a bacterial population results from the combination of a wide range of susceptibilities displayed by subsets of bacterial cells. Bacterial heteroresistance to antibiotics has been documented for several opportunistic Gram-negative bacteria, but the mechanism of heteroresistance is unclear. We use Burkholderia cenocepacia as a model opportunistic bacterium to investigate the implications of heterogeneity in the response to the antimicrobial peptide polymyxin B (PmB and also other bactericidal antibiotics. Here, we report that B. cenocepacia is heteroresistant to PmB. Population analysis profiling also identified B. cenocepacia subpopulations arising from a seemingly homogenous culture that are resistant to higher levels of polymyxin B than the rest of the cells in the culture, and can protect the more sensitive cells from killing, as well as sensitive bacteria from other species, such as Pseudomonas aeruginosa and Escherichia coli. Communication of resistance depended on upregulation of putrescine synthesis and YceI, a widely conserved low-molecular weight secreted protein. Deletion of genes for the synthesis of putrescine and YceI abrogate protection, while pharmacologic inhibition of putrescine synthesis reduced resistance to polymyxin B. Polyamines and YceI were also required for heteroresistance of B. cenocepacia to various bactericidal antibiotics. We propose that putrescine and YceI resemble "danger" infochemicals whose increased production by a bacterial subpopulation, becoming more resistant to bactericidal antibiotics, communicates higher level of resistance to more sensitive members of the population of the same or different species.

  2. High resistivity In-doped ZnTe: electrical and optical properties

    Indian Academy of Sciences (India)

    Unknown

    Semi-insulating ZnTe prepared by In doping during Bridgman growth was found to have a resistivity of 5⋅74 × 107 ohm-cm, ... Thermally stimulated current (TSC) studies revealed 2 trap levels at depths of 202–222 meV and ... Possible models for semi-insulating behaviour and meta-stability are proposed. Keywords.

  3. Processing of microstrip detectors on Czochralski grown high resistivity silicon substrates

    CERN Document Server

    Härkönen, J; Tuovinen, E; Mehtälä, P; Lassila-Perini, K M; Ovchinnikov, V; Heikkilä, P; Ylikoski, M; Palmu, L; Kallijärvi, S; Nikkila, H; Anttila, O; Niinikoski, T O; Eremin, V; Ivanov, A; Verbitskaya, E

    2003-01-01

    We have processed large-area strip sensors on silicon wafers grown by the magnetic Czochralski (MCZ) method. The n-type MCZ silicon wafers manufactured by Okmetic Oyj have nominal resistivity of 900 Omega cm and oxygen concentration of less than 10 ppma. The Photoconductive Decay (PCD) measurements, current-voltage measurements and capacitance-voltage measurements were made to characterise the samples. The leakage current of 3 muA at 900 V bias voltage was measured on the 32.5 cm**2 detector. Detector depletion took place at about 420 V. According to PCD measurements, process induced contamination was effectively bound and neutralised by the oxygen present in Czochralski silicon. During the sample processing, the silicon resistivity increased in spite of the lack of specific donor- killing heat treatment.

  4. Radiation hard pixel sensors using high-resistive wafers in a 150 nm CMOS processing line

    Science.gov (United States)

    Pohl, D.-L.; Hemperek, T.; Caicedo, I.; Gonella, L.; Hügging, F.; Janssen, J.; Krüger, H.; Macchiolo, A.; Owtscharenko, N.; Vigani, L.; Wermes, N.

    2017-06-01

    Pixel sensors using 8'' CMOS processing technology have been designed and characterized offering the benefits of industrial sensor fabrication, including large wafers, high throughput and yield, as well as low cost. The pixel sensors are produced using a 150 nm CMOS technology offered by LFoundry in Avezzano. The technology provides multiple metal and polysilicon layers, as well as metal-insulator-metal capacitors that can be employed for AC-coupling and redistribution layers. Several prototypes were fabricated and are characterized with minimum ionizing particles before and after irradiation to fluences up to 1.1 × 1015 neq cm-2. The CMOS-fabricated sensors perform equally well as standard pixel sensors in terms of noise and hit detection efficiency. AC-coupled sensors even reach 100% hit efficiency in a 3.2 GeV electron beam before irradiation.

  5. Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut

    Science.gov (United States)

    The corn smut fungus, Ustilago maydis, is a global pathogen responsible for extensive agricultural losses. Control of corn smut using traditional breeding has met with limited success because natural resistance to U. maydis is organ specific and involves numerous maize genes. Here, we present a tran...

  6. Improvement of the third harmonic based stator ground fault protection for high resistance grounded synchronous generators

    Directory of Open Access Journals (Sweden)

    Byron Ruíz-Mondragón

    2010-01-01

    Full Text Available En éste artículo se presenta una comparación y una propuesta de mejoramiento de tres diferentes métodos de protección del 100% del estator en el caso de fallas a tierra, aplicados a generadores síncronos aterrizados mediante una alta resistencia. Los tres métodos están basados en las mediciones de tercer armónico de tensión en el neutro, en los terminales de la máquina y en la relación de las dos medidas anteriores. De los resultados obtenidos en generador síncrono real, se puede apreciar que el esquema basado en la relación de las tensiones de tercer armónico medido en los terminales y en el neutro es la mejor alternativa, en el caso de utilizar la estrategia de umbrales de tensión. Sin embargo, mediante la utilización de una estrategia propuesta basada en una lógica para alarma y disparo, se pueden apreciar notables mejoras en la capacidad de detección de fallas a tierra de alta impedancia. Finalmente, este trabajo puede contribuir al desarrollo de elementos de protección útiles para detectar fallas a tierra en los devanados del estator de un generador síncrono. Aunque una primera falla normalmente no causa ningún problema, ésta tiene que ser atendida prontamente antes que una segunda falla pueda causar graves daños en la máquina y su consiguiente salida del servicio.

  7. Studying boundary elements’ behaviour using masonry walls built with high-resistance bricks

    Directory of Open Access Journals (Sweden)

    Juan Carlos Restrepo Mejía

    2006-05-01

    Full Text Available This research was aimed at studying the behaviour of masonry walls built with and without boundary elements at both ends when sublected to monotonic and cyclic lateral loads. The walls were designed to have the greatest resistance, following NSR-98 recommendations (normas Colombianas de diseno y construcción sismo resistente, except for shear reinforcement. XTRACT software was used for finding axial load cf bending moment and curvature cf bending moment curves. One monotonic test and two cyclic tests were performed for each type of wall. Experimental results from the walls’ lateral load cf displacement curves were used for determining their ability to dissipate energy on an inelastic range (“R” force-reduction factor for seismic loads and displacement and curvature malleability. It was found that walls built without boundary elements suffered shear failure with cracks in a stepped configuration along the bricks’ edge. The type of failure for walls built with boundary elements was shear failure in the central panel with cracks in a stepped configuration, in addition to compression failure at the edge of the boundary elements with vertical cracks on the lower part of the wall and at the contact between the wall and the boundary element. Comparison with two other studies carried out at the Universidad Nacional showed similar cyclic behaviour, regardless of the clay brick’s strength. The “R” values obtained for both types of walls were lower than the recommended values given by NSR-98. It was determined that walls having boundary element have greater displacement malleability than walls without boundary elements.

  8. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder.

    Science.gov (United States)

    Greenberg, Benjamin D; Malone, Donald A; Friehs, Gerhard M; Rezai, Ali R; Kubu, Cynthia S; Malloy, Paul F; Salloway, Stephen P; Okun, Michael S; Goodman, Wayne K; Rasmussen, Steven A

    2006-11-01

    Deep brain stimulation (DBS) of the anterior limb of the internal capsule has been shown to be beneficial in the short term for obsessive-compulsive disorder (OCD) patients who exhaust conventional therapies. Nuttin et al, who published the first DBS for OCD series, found promising results using a capsule target immediately rostral to the anterior commissure extending into adjacent ventral capsule/ventral striatum (VC/VS). Published long-term outcome data are limited to four patients. In this collaborative study, 10 adult OCD patients meeting stringent criteria for severity and treatment resistance had quadripolar stimulating leads implanted bilaterally in the VC/VS. DBS was activated openly 3 weeks later. Eight patients have been followed for at least 36 months. Group Yale-Brown Obsessive Compulsive Scale (YBOCS) scores decreased from 34.6+/-0.6 (mean+/-SEM) at baseline (severe) to 22.3+/-2.1 (moderate) at 36 months (p or =35% decrease in YBOCS severity at 36 months; in two patients, scores declined between 25 and 35%. Global Assessment of Functioning scores improved from 36.6+/-1.5 at baseline to 53.8+/-2.5 at 36 months (p OCD when DBS was interrupted by stimulator battery depletion. This open study found promising long-term effects of DBS in highly treatment-resistant OCD.

  9. LePix-A high resistivity, fully depleted monolithic pixel detector

    CERN Document Server

    Giubilato, P; Mugnier, H; Bisello, D; Marchioro, A; Snoeys, W; Denes, P; Pantano, D; Rousset, J; Mattiazzo, S; Kloukinas, K; Potenza, A; Rivetti, A; Chalmet, P

    2013-01-01

    The LePix project explores monolithic pixel sensors fabricated in a 90 nm CMOS technology built over a lightly doped substrate. This approach keeps the advantages usually offered by Monolithic Active Pixel Sensors (MAPS), like a low input capacitance, having a single piece detector and using a standard CMOS production line, and adds the benefit of charge collection by drift from a depleted region several tens of microns deep into the substrate, therefore providing an excellent signal to noise ratio and a radiation tolerance superior to conventional un-depleted MAPS. Such sensors are expected to offer significant cost savings and reduction of power consumption for the same performance, leading to the use of much less material in the detector (less cooling and less copper), addressing one of the main limitations of present day particle tracking systems. The latest evolution of the project uses detectors thinned down to 50 mu m to obtain back illuminated sensors operated in full depletion mode. By back processin...

  10. Study of high resistance inorganic coatings on graphite fibers. [for graphite-epoxy composite materials

    Science.gov (United States)

    Galasso, F. S.; Veltri, R. D.; Scola, D. A.

    1979-01-01

    Coatings made of boron, silicon carbide, silica, and silica-like materials were studied to determine their ability to increase resistance of graphite fibers. The most promising results were attained by chemical vapor depositing silicon carbide on graphite fiber followed by oxidation, and drawing graphite fiber through ethyl silicate followed by appropriate heat treatments. In the silicon carbide coating studies, no degradation of the graphite fibers was observed and resistance values as high as three orders of magnitude higher than that of the uncoated fiber was attained. The strength of a composite fabricated from the coated fiber had a strength which compared favorably with those of composites prepared from uncoated fiber. For the silica-like coated fiber prepared by drawing the graphite fiber through an ethyl silicate solution followed by heating, coated fiber resistances about an order of magnitude greater than that of the uncoated fiber were attained. Composites prepared using these fibers had flexural strengths comparable with those prepared using uncoated fibers, but the shear strengths were lower.

  11. Development of Press Hardening Steel with High Resistance to Hydrogen Embrittlement

    Science.gov (United States)

    Bian, Jian; Mohrbacher, Hardy; Lu, Hongzhou; Wang, Wenjun

    Press hardening has become the state-of-art technology in the car body manufacturing to enhance safety standard and to reduce CO2 emission of new vehicles. However the delayed cracking due to hydrogen embrittlement remains to be a critical issue. Generally press hardening steel is susceptible to hydrogen embrittlement due to ultra-high strength and martensitic microstructure. The hydrogen charging tests clearly demonstrate that only a few ppm of diffusible hydrogen is sufficient to cause such embrittlement. Currently the hydrogen embrittlement cannot be detected in the press hardened components and the embitteled components could collapse in the crash situation with fatal consequences arisen through dramatic loss in both strength and ductility. This paper introduces a new metallurgical solution to increase the resistance to hydrogen embrittlement of conventional press hardening steel based on 22MnB5 by Nb microalloying. In the hydrogen embrittlement and permeation tests the impact of Nb microalloying on the hydrogen embrittlement behavior was investigated under different hydrogen charging conditions and constant load. The test results revealed that Nb addition increases the resistance to hydrogen embrittlement due to reduced hydrogen diffusivity. The focus of this paper is to investigate the precipitation behavior of microalloying elements by using TEM and STEM and to find out the mechanisms leading to higher performance against hydrogen embrittlement of Nb alloyed steels.

  12. Mature biofilms of Enterococcus faecalis and Enterococcus faecium are highly resistant to antibiotics.

    Science.gov (United States)

    Holmberg, Anna; Rasmussen, Magnus

    2016-01-01

    Enterococcus faecalis and Enterococcus faecium are important nosocomial pathogens that form biofilms on implanted materials. We compare the antibiotic sensitivity of bacteria in new (established during 24 hours) and mature (established during 120 hours) enterococcal biofilms. Mature biofilms contained more bacteria and were much more tolerant to antibiotics, including rifampicin-containing combinations, as judged by determination of minimal biofilm eradication concentrations and by time-kill experiments of bacteria in biofilms formed on beads of bone cement. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. High resistance of Pseudomonas aeruginosa to paromomycin, an agent used for selective bowel decontamination (SBD

    Directory of Open Access Journals (Sweden)

    Daxboeck, Florian

    2013-04-01

    Full Text Available [english] Background: Paromomycin is used for selective bowel decontamination (SBD in patients undergoing bone marrow transplantation in many hospitals, but there are no published resistance data for this compound in the recent medical literature. The aim of this study was to investigate the in vitro activity of paromomycin against the common intestinal bacteria and .Methods: 94 isolates and 77 isolates derived from clinical specimens were tested by broth microdilution against paromomycin and amikacin, respectively, following the CLSI recommendations for testing amikacin.Results: 86 of 94 isolates (91% and 71 of 77 isolates (92% showed in vitro susceptibility to amikacin (MIC90 for both compounds: 16 µg/ml, range: 1–32 µg/ml for and for. Paromomycin was active against 83/94 isolates (88%; MIC90: 32 µg/ml, range: 2–>128 µg/ml, but showed poor in vitro activity against (3/77 isolates susceptible [4%]; MIC90: >128 µg/ml, range: 2–>128 µg/ml.Conclusion: If SBD with inclusion of an aminoglycoside antibiotic is applied, paromomycin should not be used unless local resistance data provide evidence of a sufficient in vitro activity of this compound against .

  14. Detoxification of toxic heavy metals by marine bacteria highly resistant to mercury

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.; Vardanyan, L.

    isolate), Pseudomonas aeruginosa (one isolate), and Brevibacterium iodinium (one isolate). The mechanisms of heavy metal detoxification were through volatilization (for Hg), putative entrapment in the extracellular polymeric substance (for Hg, Cd and Pb...

  15. Characterization of marine bacteria highly resistant to mercury exhibiting multiple resistances to toxic chemicals

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.

    of various heavy metals and xenobiotics were also checked. 2. Materials and methods 2.1. Bacterial isolates Mercury-resistant bacteria (MRB) in water and sediment complexes were isolated from various locations along the Indian coast during 1999...-2002 using seawater nutrient agar (SWNA: 5.0 g peptone, 1.5 g beef extract, 1.5 g yeast extract, 500 ml aged seawater, 500 ml deionised water and 15 g agar) amended with 10 ppm (? 50 ?M Hg) HgCl2 (Merck, Germany). After enumerating MRB several single...

  16. A double EPSPS gene mutation endowing glyphosate resistance shows a remarkably high resistance cost.

    Science.gov (United States)

    Han, Heping; Vila-Aiub, Martin M; Jalaludin, Adam; Yu, Qin; Powles, Stephen B

    2017-12-01

    A novel glyphosate resistance double point mutation (T102I/P106S, TIPS) in the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene has been recently identified for the first time only in the weed species Eleusine indica. Quantification of plant resistance cost associated with the TIPS and the often reported glyphosate resistance single P106S mutation was performed. A significant resistance cost (50% in seed number currency) associated with the homozygous TIPS but not the homozygous P106S EPSPS variant was identified in E. indica plants. The resistance cost associated with the TIPS mutation escalated to 85% in plants under resource competition with rice crops. The resistance cost was not detected in nonhomozygous TIPS plants denoting the recessive nature of the cost associated with the TIPS allele. An excess of 11-fold more shikimate and sixfold more quinate in the shikimate pathway was detected in TIPS plants in the absence of glyphosate treatment compared to wild type, whereas no changes in these compounds were observed in P106S plants when compared to wild type. TIPS plants show altered metabolite levels in several other metabolic pathways that may account for the expression of the observed resistance cost. © 2017 John Wiley & Sons Ltd.

  17. Providencia stuartii form biofilms and floating communities of cells that display high resistance to environmental insults.

    Directory of Open Access Journals (Sweden)

    Mariam El Khatib

    Full Text Available Biofilms are organized communities of bacterial cells that are responsible for the majority of human chronic bacterial infections. Providencia stuartii is a Gram-negative biofilm-forming bacterium involved in high incidence of urinary tract infections in catheterized patients. Yet, the structuration of these biofilms, and their resistance to environmental insults remain poorly understood. Here, we report on planktonic cell growth and biofilm formation by P. stuartii, in conditions that mimic its most common pathophysiological habitat in humans, i.e. the urinary tract. We observed that, in the planktonic state, P. stuartii forms floating communities of cells, prior to attachment to a surface and subsequent adoption of the biofilm phenotype. P. stuartii planktonic and biofilm cells are remarkably resistant to calcium, magnesium and to high concentrations of urea, and show the ability to grow over a wide range of pHs. Experiments conducted on a P. stuartii strain knocked-out for the Omp-Pst2 porin sheds light on the role it plays in the early stages of growth, as well as in the adaptation to high concentration of urea and to varying pH.

  18. Sea otter dental enamel is highly resistant to chipping due to its microstructure.

    Science.gov (United States)

    Ziscovici, Charles; Lucas, Peter W; Constantino, Paul J; Bromage, Timothy G; van Casteren, Adam

    2014-10-01

    Dental enamel is prone to damage by chipping with large hard objects at forces that depend on chip size and enamel toughness. Experiments on modern human teeth have suggested that some ante-mortem chips on fossil hominin enamel were produced by bite forces near physiological maxima. Here, we show that equivalent chips in sea otter enamel require even higher forces than human enamel. Increased fracture resistance correlates with more intense enamel prism decussation, often seen also in some fossil hominins. It is possible therefore that enamel chips in such hominins may have formed at even greater forces than currently envisaged. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  19. Highly loaded behavior of kinesins increases the robustness of transport under high resisting loads.

    Directory of Open Access Journals (Sweden)

    Woochul Nam

    2015-03-01

    Full Text Available Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads. However, kinesins perform much longer range transport in cells by working collectively. This long range of transport by a team of kinesins is surprising because the motion of the cargo in cells can be hindered by other particles. To reveal how the kinesins are able to accomplish their tasks of transport in harsh intracellular circumstances, stochastic studies on the kinesin motion are performed by considering the binding and unbinding of kinesins to microtubules and their dependence on the force acting on kinesin molecules. The unbinding probabilities corresponding to each mechanochemical state of kinesin are modeled. The statistical characterization of the instants and locations of binding are captured by computing the probability of unbound kinesin being at given locations. It is predicted that a group of kinesins has a more efficient transport than a single kinesin from the perspective of velocity and run length. Particularly, when large loads are applied, the leading kinesin remains bound to the microtubule for long time which increases the chances of the other kinesins to bind to the microtubule. To predict effects of this behavior of the leading kinesin under large loads on the collective transport, the motion of the cargo is studied when the cargo confronts obstacles. The result suggests that the behavior of kinesins under large loads prevents the early termination of the transport which can be caused by the interference with the static or moving obstacles.

  20. Highly loaded behavior of kinesins increases the robustness of transport under high resisting loads.

    Science.gov (United States)

    Nam, Woochul; Epureanu, Bogdan I

    2015-03-01

    Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads. However, kinesins perform much longer range transport in cells by working collectively. This long range of transport by a team of kinesins is surprising because the motion of the cargo in cells can be hindered by other particles. To reveal how the kinesins are able to accomplish their tasks of transport in harsh intracellular circumstances, stochastic studies on the kinesin motion are performed by considering the binding and unbinding of kinesins to microtubules and their dependence on the force acting on kinesin molecules. The unbinding probabilities corresponding to each mechanochemical state of kinesin are modeled. The statistical characterization of the instants and locations of binding are captured by computing the probability of unbound kinesin being at given locations. It is predicted that a group of kinesins has a more efficient transport than a single kinesin from the perspective of velocity and run length. Particularly, when large loads are applied, the leading kinesin remains bound to the microtubule for long time which increases the chances of the other kinesins to bind to the microtubule. To predict effects of this behavior of the leading kinesin under large loads on the collective transport, the motion of the cargo is studied when the cargo confronts obstacles. The result suggests that the behavior of kinesins under large loads prevents the early termination of the transport which can be caused by the interference with the static or moving obstacles.

  1. Dutch guideline for preventing nosocomial transmission of highly resistant microorganisms (HRMO).

    NARCIS (Netherlands)

    Kluytmans-Vandenbergh, M.F.; Kluytmans, J.A.J.W.; Voss, A.

    2005-01-01

    Hospitals are faced with the increasingly rapid emergence and dissemination of antimicrobial-resistant microorganisms. US and European guidelines on the prevention of antimicrobial resistance in hospitals were, until recently, mainly directed at methicillin-resistant Staphylococcus aureus (MRSA). In

  2. High resistivity In-doped ZnTe: electrical and optical properties

    Indian Academy of Sciences (India)

    insulating ZnTe prepared by In doping during Bridgman growth was found to have a resistivity of 5.74 × 107 ohm-cm, the highest reported so far in ZnTe, with ... Possible models for semi-insulating behaviour and meta-stability are proposed.

  3. [The forms and frequency of renal parenchymal cones].

    Science.gov (United States)

    Kara, Murat; Tuma, Jan

    2014-02-12

    The renal parenchymal cone (RPC) is an important differential diagnosis to the real kidney tumors. It is defined as at least 15 mm large part of the normal renal parenchyma which protrudes into the space of the renal sinus. If the RPC is solely formed from renal cortical tissue, it is called "Column of Bertin" renal parenchymal cones (CB-RPC). If the renal medulla is part of RPC, together with the renal cortex, it is called lobular renal parenchymal cones (L-RPC). The aim of this prospective study was to determine the frequency of CB-RPC and the L-RPC. 200 kidneys from 100 patients were evaluated. At least one RPC was found in 53 patients. 27 RPC were on both sides. CB-RPC was present in 27,5% of the kidneys, a L-RPC in 12,5%. The high frequency of RPC underlines its importance in the diagnosis of focal renal parenchymal changes.

  4. The multigap resistive plate chamber

    Energy Technology Data Exchange (ETDEWEB)

    Zeballos, E. Cerron [European Organization for Nuclear Research (CERN), Geneva (Switzerland); World Lab., Lausanne (Switzerland); Crotty, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Hatzifotiadou, D. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); World Lab., Lausanne (Switzerland); Valverde, J. Lamas [European Organization for Nuclear Research (CERN), Geneva (Switzerland); World Lab., Lausanne (Switzerland); Univ. Louis Pasteur, Strasbourg (France); Neupane, S. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); World Lab., Lausanne (Switzerland); Williams, M. C. S. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Zichichi, A. [Univ. of Bologna, Bologna (Italy)

    2015-02-03

    The paper describes the multigap resistive plate chamber (RPC). This is a variant of the wide gap RPC. However it has much improved time resolution, while keeping all the other advantages of the wide gap RPC design.

  5. HISTÓRICO E ATUALIDADE DA POLÍTICA DE SAÚDE NA REPÚBLICA POPULAR DA CHINA (RPC

    Directory of Open Access Journals (Sweden)

    Neide César Vargas

    2015-01-01

    Full Text Available China, due to its special culture, political regime and economy, presents a health system with remarkable differences from those of Western and capitalist nations, which can be obliterated in an exclusively quantitative approach of this system. Taking into account these aspects, this article attempts to undertake an overview of the development of the health system in the PRC during the three main stages of the country’s recent history, namely the era of Mao Zedong (1949-1976, the era of Deng Xiaoping (1978-1994 and the current period.

  6. Detection of muons in the LHCb experiment the aging of RPC detectors and the study of $Z^0 \\to \\mu^+ \\mu^-$

    CERN Document Server

    Domenici, Danilo; Carboni, G

    2003-01-01

    The LHCb experiment will take place at the future LHC accelerator at CERN and will start in 2007. It is a single arm spectrometer dedicated to precision measure- ments of CP violation and rare decays in the b quark sector . Recent experimental results have shown that CP violation is large in this sector . LHCb is designed with a robust and exible trigger , in order to extensively gain access to a wide spread of different physical processes involving the beauty particles. This will allow to over-constrain the Standard Model predictions about CP violation, and to discover any possible inconsistency , which would reveal the presence of ìNew Physicsî. The work presented in this thesis has two main parts: the development of the Resistive Plate Chambers, proposed for the detection of muons in LHCb, and the study of the detector performances in the physical channel Z 0 -> u + u -. The LHCb experiment has nished its R&D at the end of 2002. We have par- ticipated in the development of a suitable detector for...

  7. Synthesis and characterization of phenol/formaldehyde nanocomposites: Studying the effect of incorporating reactive rubber nanoparticles or Cloisite-30B nanoclay on the mechanical properties, morphology and thermal stability

    Directory of Open Access Journals (Sweden)

    Walaa S.E. Solyman

    2017-01-01

    Full Text Available In this work, phenol/formaldehyde nanocomposites were synthesized using reactive rubber nanoparticles (RRNP and cloisite30B nanoclay with different percentages and were fully investigated. A little amount of these nanomaterials enhanced the mechanical properties of the produced composites. This enhancement is attributed to the interaction of these nanomaterials with the bakelite matrix. In bakelite/RRNP, the mechanical properties enhancement is due to the chemical connection of RRNP to the bakelite matrix while in bakelite/Cloisite30B, this enhancement is due to polar/polar interaction. It was observed that the composites exhibited an intercalated disordered structure by means of Xray diffraction (XRD and transmission electronic microscopy. The crosslinking density of the bakelite network was greatly influenced by the presence and type of nanomaterial that was added to the resin. The thermal stability was investigated with TGA/DSC which proved that these nanocomposite are (10–20% more thermally stable than neat Bakelite resin.

  8. Magnetotelluric characterization of a tectonic boundary in the Chaco-Pampean Plain (27° S), Argentina

    Science.gov (United States)

    Peri, V. G.; Pomposiello, C.; Favetto, A.; Barcelona, H.; Rossello, E.

    2013-05-01

    to determine lithospheric structures beneath thick sedimentary basins. So, MT data were processed and the dimensionality and distortion of the geoelectrical medium were analyzed. Finally, a 2-D inversion model was performed over a mesh with known geological constraints. The image distribution of the electrical resistivity at lithosphere scale shows a highly resistive crust (> 100,000 Ω m) in the east side of the profile, correlated with the RPC. In the west side of the profile, a less but still highly resistive crust (~ 12,000 Ω m) was correlated with the PT. Both highly resistive blocks are separated by an east dipping conductive anomaly (100-200 Ω m) correlated with the Transbrasiliano lineament. This conductive feature agrees with the east dipping subduction model and can be explained by the presence of graphite presumably lying in paleosutures of long-stable geological terranes. An oblique convergence between both terranes could develop a transpressional shear belt. Results provide a geoelectrical characterization at lithospheric scale beneath the Chaco-Pampean Plain and a new geophysical evidence of the tectonic boundary between the RPC and the PT, improving the knowledge of the Western Gondwana amalgamation.

  9. Tested Demonstrations.

    Science.gov (United States)

    Gilbert, George L., Ed.

    1978-01-01

    Presents the following chemistry lecture demonstrations and experiments: (1) a versatile kinetic demonstration; (2) the Bakelite Demonstration; (3) applying Beer's law; and (4) entropy calculations. (HM)

  10. Application of new directional logic to improve DC side fault discrimination for high resistance faults in HVDC grids

    National Research Council Canada - National Science Library

    HALEEM, Naushath M; RAJAPAKSE, Athula D

    2017-01-01

    .... The proposed protection scheme is applied to a multi-level modular converter based three-terminal HVDC grid and its security and sensitivity are evaluated through electromagnetic transient simulations...

  11. High Resistance to Azithromycin in Clinical Samples from Patients with Sexually Transmitted Diseases in Guangxi Zhuang Autonomous Region, China.

    Science.gov (United States)

    Zhu, Bangyong; Bu, Jin; Li, Wei; Zhang, Jie; Huang, Geng; Cao, Juan; Tang, Zhongshu; Gan, Quan; Wei, Pingjiang

    2016-01-01

    Azithromycin is used as an alternative medicine in patients with syphilis who are intolerant to penicillin. Nevertheless, the report of treatment failure of azithromycin for patients with syphilis has raised concerns in China in the past years. In this study, 178 patients with early syphilis, who were treated in sexually transmitted infections clinics in four cities in Guangxi Zhuang Autonomous Region were enrolled to investigate the regional prevalence of Treponema pallidum strain resistant to azithromycin. Nested PCR was performed to amplify the 23S ribosomal RNA (23SrRNA) gene. The point mutation of A2058G in 23SrRNA, which confers Treponema pallidum resistance to azithromycin, was measured by endonuclease digestion of PCR amplification products using MboII. A2058G point mutation was detected in 91.0% (162/178; 95% CI, 86.8%, 95.2%) of the specimens, but no difference in prevalence of azithromycin resistance was found between the patients who had taken antibiotics before enrollment and the patients who had not (91.8% vs. 89.4%), nor between the patients with and without past sexually transmitted infections (87.1% vs. 93.1%). We concluded that azithromycin may not be suitable for syphilis as a treatment option in Guangxi Zhuang Autonomous Region because of the extremely high prevalence of resistance in the general syphilis population.

  12. Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature

    Directory of Open Access Journals (Sweden)

    Thomas G. P. Grunewald

    2010-01-01

    Full Text Available Sclerosing epithelioid fibrosarcoma (SEF is a rare soft tissue sarcoma mostly occurring in extraosseous sites. SEF represents a clinically challenging entity especially because no standardized treatment regimens are available. Intraosseous localization is an additional challenge with respect to the therapeutical approach. We report on a 16-year-old patient with SEF of the right proximal tibia. The patient underwent standardized neoadjuvant chemotherapy analogous to the EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprosthetic reconstruction. Histopathological analysis of the resected tumor showed >90% vital tumor cells suggesting no response to chemotherapy. Therefore, therapy was reassigned to the CWS 2002 High-Risk protocol for the treatment of soft tissue sarcoma. To date (22 months after diagnosis, there is no evidence of relapse or metastasis. Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin, and Methotrexate, which should be considered in planning treatment for patients with SEF.

  13. Resource-efficient development of thermally highly resistant engine components of hybrid metal composites - experiments and numerical analysis

    OpenAIRE

    Landgrebe, Dirk; Krüger, Lutz; Schubert, Nadine; Jentsch, Eric; Lehnert, Tim

    2017-01-01

    Requirements for protection of environment and climate, increasing energy cost and security demands form the basis for research activities in the maritime sector. Within the scope of the joint project »INKOV – development of innovative piston and valve solutions for composites in ship engines« metallic composites are developed and investigated. Their application in large engines powered by heavy fuel oil shall reduce nitrogen oxide emissions. The investigations of the publicly funded research...

  14. PdAgAu alloy with high resistance to corrosion by H2S

    Energy Technology Data Exchange (ETDEWEB)

    Braun, Fernando [Inst. de Investigaciones en Catalisis y Petroquimica, Santa Fe (Argentina); Miller, James B. [Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Chemical Engineering; National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Gellman, Andrew J. [Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Chemical Engineering; National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Tarditi, Ana M. [Inst. de Investigaciones en Catalisis y Petroquimica, Santa Fe (Argentina); Fleutot, Benoit [Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Chemical Engineering; Kondratyuk, Petro [Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Chemical Engineering; National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Cornaglia, Laura M. [Inst. de Investigaciones en Catalisis y Petroquimica, Santa Fe (Argentina)

    2012-12-01

    PdAgAu alloy films were prepared on porous stainless steel supports by sequential electroless deposition. Two specific compositions, Pd83Ag2Au15 and Pd74Ag14Au12, were studied for their sulfur tolerance. The alloys and a reference Pd foil were exposed to 1000 H2S /H2 at 623 K for periods of 3 and 30 hours. The microstructure, morphology and bulk composition of both nonexposed and H2S-exposed samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). XRD and SEM analysis revealed time-dependent growth of a bulk Pd{sub 4}S phase on the Pd foil during H2S exposure. In contrast, the PdAgAu ternary alloys displayed the same FCC structure before and after H2S exposure. In agreement with the XRD and SEM results, sulfur was not detected in the bulk of either ternary alloy samples by EDS, even after 30 hours of H2S exposure. X-ray photoelectron spectroscopy (XPS) depth profiles were acquired for both PdAgAu alloys after 3 and 30 hours of exposure to characterize sulfur contamination near their surfaces. Very low S 2p and S 2s XPS signals were observed at the top-surfaces of the PdAgAu alloys, and those signals disappeared before the etch depth reached ~ 10 nm, even for samples exposed to H2S for 30 hours. The depth profile analyses also revealed silver and gold segregation to the surface of the alloys; preferential location of Au on the alloys surface may be related to their resistance to bulk sulfide formation. In preliminary tests, a PdAgAu alloy membrane displayed higher initial H{sub 2} permeability than a similarly prepared pure Pd sample and, consistent with resistance to bulk sulfide formation, lower permeability loss in H2S than pure Pd.

  15. Spin-sprayed ferrite films with high resistivity and high-frequency magnetic loss for GHz conducted noise suppressors

    Energy Technology Data Exchange (ETDEWEB)

    Subramani, A.K. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama (Japan)], E-mail: subramani.aa@m.titech.ac.jp; Matsushita, N. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama (Japan)], E-mail: matsushita@msl.titech.ac.jp; Watanabe, T. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama (Japan); Tada, M.; Abe, M. [Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552 (Japan); Kondo, K. [NEC Tokin Corporation, 6-7-1 Koriyama, Taihaku-ku, Sendai, Miyagi 982-8510 (Japan); Yoshimura, M. [Materials and Structures Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama (Japan)

    2008-02-25

    In the present study, crystallized ferrite (an intermediate between Fe{sub 3}O{sub 4} and {gamma}-Fe{sub 2}O{sub 3}) films prepared by spin-spray technique exhibited strong magnetic losses at high frequencies and are applicable as GHz conducted noise suppressors. The reaction (metal ions) and oxidizing (pH buffers and oxidizing agent) solutions were separately sprayed onto the substrates (90 deg. C) mounted on a rotating disc. Two types of films were prepared on the basis of the different oxidizing solutions; CH{sub 3}COONa + NaNO{sub 2} in the case of film-A and CH{sub 3}COONa + (NH{sub 4}){sub 2}CO{sub 3} + NaNO{sub 2} + NaOH for film-B. The as-prepared films were heat-treated under a condition similar to that of the reflow soldering process (265 deg. C). The effects of the preparation conditions and film morphology on the electrical and magnetic properties before and after the heat treatment were studied. The results revealed that film-B had a relatively smaller initial permeability ({mu}') compared to film-A. However, it had a high-imaginary permeability ({mu}''), resonance frequency (f{sub r}) and surface resistivity ({rho}{sub s}) even after heat treatment. Also, the noise suppressing properties of film-B were relatively good, hence ideal for use as conducted noise suppressors.

  16. Application of the Na+ recirculation theory to ion coupled water transport in low- and high resistance osmoregulatory epithelia

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Møbjerg, Nadja; Nielsen, Robert

    2007-01-01

    The theory of Na+ recirculation for isosmotic fluid absorption follows logically from Hertz's convection-diffusion equation applied to the exit of water and solutes from the lateral intercellular space. Experimental evidence is discussed indicating Na+ recirculation based upon the following...

  17. Voltage amplification of thermopower waves via current crowding at high resistances in self-propagating combustion waves

    Science.gov (United States)

    Yeo, Taehan; Hwang, Hayoung; Cho, Yonghwan; Shin, Dongjoon; Choi, Wonjoon

    2015-07-01

    Combustion wave propagation in micro/nanostructured materials generates a chemical-thermal-electrical energy conversion, which enables the creation of an unusual source of electrical energy, called a thermopower wave. In this paper, we report that high electrical resistance regimes would significantly amplify the output voltage of thermopower waves, because the current crowding creates a narrow path for charge carrier transport. We show that the structurally defective regions in the hybrid composites of chemical fuels and carbon nanotube (CNT) arrays determine both the resistance levels of the hybrid composites and the corresponding output voltage of thermopower waves. A sudden acceleration of the crowded charges would be induced by the moving reaction front of the combustion wave when the supplied driving force overcomes the potential barrier to cause charge carrier transport over the defective region. This property is investigated experimentally for the locally manipulated defective areas using diverse methods. In this study, thermopower waves in CNT-based hybrid composites are able to control the peak voltages in the range of 10-1000 mV by manipulating the resistance from 10 Ω to 100 kΩ. This controllable voltage generation from thermopower waves may enable applications using the combustion waves in micro/nanostructured materials and better understanding of the underlying physics.

  18. Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative rods.

    Directory of Open Access Journals (Sweden)

    E Ascelijn Reuland

    Full Text Available OBJECTIVES: The aim of this study was to compare the current screening methods and to evaluate confirmation tests for phenotypic plasmidal AmpC (pAmpC detection. METHODS: For this evaluation we used 503 Enterobacteriaceae from 18 Dutch hospitals and 21 isolates previously confirmed to be pAmpC positive. All isolates were divided into three groups: isolates with 1 reduced susceptibility to ceftazidime and/or cefotaxime; 2 reduced susceptibility to cefoxitin; 3 reduced susceptibility to ceftazidime and/or cefotaxime combined with reduced susceptibility to cefoxitin. Two disk-based tests, with cloxacillin or boronic acid as inhibitor, and Etest with cefotetan-cefotetan/cloxacillin were used for phenotypic AmpC confirmation. Finally, presence of pAmpC genes was tested by multiplex and singleplex PCR. RESULTS: We identified 13 pAmpC producing Enterobacteriaceae isolates among the 503 isolates (2.6%: 9 CMY-2, 3 DHA-1 and 1 ACC-1 type in E. coli isolates. The sensitivity and specificity of reduced susceptibility to ceftazidime and/or cefotaxime in combination with cefoxitin was 97% (33/34 and 90% (289/322 respectively. The disk-based test with cloxacillin showed the best performance as phenotypic confirmation method for AmpC production. CONCLUSIONS: For routine phenotypic detection of pAmpC the screening for reduced susceptibility to third generation cephalosporins combined with reduced susceptibility to cefoxitin is recommended. Confirmation via a combination disk diffusion test using cloxacillin is the best phenotypic option. The prevalence found is worrisome, since, due to their plasmidal location, pAmpC genes may spread further and increase in prevalence.

  19. Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative Rods

    NARCIS (Netherlands)

    E.A. Reuland (E. Ascelijn); J.P. Hays (John); D.M.C. de Jongh (Denise); E. Abdelrehim (Eman); I. Willemsen (Ina); J.A.J.W. Kluytmans (Jan); P.H.M. Savelkoul (Paul); C.M.J.E. Vandenbroucke-Grauls (Christina); N.A. Naiemi (Nashwan Al)

    2014-01-01

    textabstractObjectives: The aim of this study was to compare the current screening methods and to evaluate confirmation tests for phenotypic plasmidal AmpC (pAmpC) detection. Methods: For this evaluation we used 503 Enterobacteriaceae from 18 Dutch hospitals and 21 isolates previously confirmed to

  20. Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative rods.

    Science.gov (United States)

    Reuland, E Ascelijn; Hays, John P; de Jongh, Denise M C; Abdelrehim, Eman; Willemsen, Ina; Kluytmans, Jan A J W; Savelkoul, Paul H M; Vandenbroucke-Grauls, Christina M J E; al Naiemi, Nashwan

    2014-01-01

    The aim of this study was to compare the current screening methods and to evaluate confirmation tests for phenotypic plasmidal AmpC (pAmpC) detection. For this evaluation we used 503 Enterobacteriaceae from 18 Dutch hospitals and 21 isolates previously confirmed to be pAmpC positive. All isolates were divided into three groups: isolates with 1) reduced susceptibility to ceftazidime and/or cefotaxime; 2) reduced susceptibility to cefoxitin; 3) reduced susceptibility to ceftazidime and/or cefotaxime combined with reduced susceptibility to cefoxitin. Two disk-based tests, with cloxacillin or boronic acid as inhibitor, and Etest with cefotetan-cefotetan/cloxacillin were used for phenotypic AmpC confirmation. Finally, presence of pAmpC genes was tested by multiplex and singleplex PCR. We identified 13 pAmpC producing Enterobacteriaceae isolates among the 503 isolates (2.6%): 9 CMY-2, 3 DHA-1 and 1 ACC-1 type in E. coli isolates. The sensitivity and specificity of reduced susceptibility to ceftazidime and/or cefotaxime in combination with cefoxitin was 97% (33/34) and 90% (289/322) respectively. The disk-based test with cloxacillin showed the best performance as phenotypic confirmation method for AmpC production. For routine phenotypic detection of pAmpC the screening for reduced susceptibility to third generation cephalosporins combined with reduced susceptibility to cefoxitin is recommended. Confirmation via a combination disk diffusion test using cloxacillin is the best phenotypic option. The prevalence found is worrisome, since, due to their plasmidal location, pAmpC genes may spread further and increase in prevalence.

  1. A modified milling system, using a bimodal distribution of highly resistant ceramics. Part 1. A natural hydroxyapatite study.

    Science.gov (United States)

    Harabi, Abdelhamid; Harabi, Esma

    2015-06-01

    A careful combination of the main parameters controlling natural hydroxyapatite (NHA: Ca10(PO4)6(OH)2) production such as milling techniques, sintering temperature and holding time may lead to an interesting NHA based bio-ceramics without any foreign oxide additions. In this way, an original wet milling setup has been proposed to obtain sub-micron sized NHA powders. In order to avoid any possible NHA decomposition, a precise Ca/P ratio of NHA derived from animals was selected accordingly. Also, an alternative direct visual approach of the bone age classification was also proposed. A relative density of about 95% was obtained for powders sintered at 1300°C for 2h. The best Vickers micro-hardness and 3 point bending strength values for these sintered samples, using this proposed milling system and without any additions, were 4.7±0.3GPa and 37MPa, respectively. Finally, a complete correlation between the powder microstructure and the final product properties has been established. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. A carrier transport model in the high-resistance state of lead-methylamine iodide-based resistive memory devices

    Directory of Open Access Journals (Sweden)

    Yongwoo Kwon

    2017-08-01

    Full Text Available Methylamine lead iodide (CH3NH3PbI3, which has recently been in the spotlight as a solar cell material, has also recently shown promise for use as an active material in resistive memory cells with ultralow operation voltages, good transparencies, and flexibilities. The material’s defects, which govern its properties, differ vastly depending on the fabrication process. However, the defect chemistry is not yet entirely understood. We have therefore established a macroscopic transport model with defect-related model parameters, such as trap density, trap energy level, and Fermi level, in order to estimate these parameters for fabricated samples based on their electrical data. Our model will serve as an efficient way to analyze the properties of the active material.

  3. Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles

    NARCIS (Netherlands)

    Linden, J.W.M. van der; Camps, S.M.T.; Kampinga, G.A.; Arends, J.P.; Debets-Ossenkopp, Y.J.; Haas, P.J.; Rijnders, B.J.; Kuijper, E.J.; Tiel, F.H. van; Varga, J.; Karawajczyk, A.; Zoll, J.; Melchers, W.J.G.; Verweij, P.E.

    2013-01-01

    BACKGROUND: Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases. Selection of azole resistance may occur through exposure to azole fungicides in the environment. In the Netherlands a surveillance network was

  4. Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea.

    NARCIS (Netherlands)

    Blombach, F.; Makarova, K.S.; Marrero, J.; Siebers, B.G.; Koonin, E.V.; Oost, J. van der

    2009-01-01

    One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA

  5. Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea

    NARCIS (Netherlands)

    Blombach, F.; Makarova, K.S.; Marrero, J.; Siebers, B.; Koonin, E.V.; Oost, van der J.

    2009-01-01

    One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA

  6. Phenotypic and genotypic detection of ESBL mediated cephalosporin resistance in Klebsiella pneumoniae: emergence of high resistance against cefepime, the fourth generation cephalosporin.

    Science.gov (United States)

    Grover, S S; Sharma, Meenakshi; Chattopadhya, D; Kapoor, Hema; Pasha, S T; Singh, Gajendra

    2006-10-01

    Cephalosporins belonging to second and third generation are commonly used in India for the treatment of Klebsiella pneumoniae. Report on resistance among K. pneumoniae strains to second and third generation cephalosporins are on rise in this country, which has been attributed to emergence of strains expressing extended-spectrum beta-lactamases (ESBLs). The aim of this study was to evaluate the in vitro susceptibility of K. pneumoniae to broad-spectrum cephalosporins particularly to cefepime, a recently introduced fourth generation cephalosporin in relation to ESBL production. This study has been carried out in two phases among K. pneumoniae strains isolated between October 2001 and September 2002 (phase I, before marketing of cefepime in India) and between August 2003 and July 2004 (phase II, after marketing of cefepime in India). Minimum Inhibitory Concentration (MIC) was determined by a commercial strip containing gradient of antimicrobials (Strip E-test). Detection for ESBL production was carried out by DDST, E-test ESBL and PCR. Antimicrobial resistance profile of K. pneumoniae strains to five cephalosporins as analyzed by WHONET 5 identified 15 different resistance profiles among the 108 phase I isolates, ranging from resistance to none (19.44%) to all the five cephalosporin (8.33%) and eight different resistance profiles among the 99 phase II isolates, ranging from resistance to none (9.1%) to all the five cephalosporins (36.4%). Among the 108 phase I isolates a total of 71 (65.72%) and out of 99 phase II isolates, a total of 87 (88.0%) could be identified as ESBL producers. Among the isolates, regardless of the phase of the isolation, those characterized by production of ESBL showed overall higher frequency of resistance to cephalosporins (range 19.7-85.9% and 51.7-100% in phase I and phase II, respectively) compared to those for ESBL non-producers (range 0-13.5% and 0-25% in phase I and phase II, respectively). Ten randomly selected isolates from the most common resistance phenotypes probably belonged to a single strain as evident by MIC patterns, genotypic characterization and resistance profile to non-cephalosporin group of antimicrobials thereby pointing out the possibility of an outbreak. PCR may be regarded as a reliable method for detection of ESBL since in addition to the strains that could be identified as ESBL producers by DDST and E-test ESBL; PCR could demonstrate ESBL production among additional 32 strains (15 in phase I and 17 in phase II). Continued uses of cephalosporin group appear to be a potential risk factor for emergence of ESBL producing K. pneumoniae strains. In addition, as noted in the present study, the rise of resistance to cefepime that has been introduced recently in this country for therapeutic use could be of concern.

  7. High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581.

    Science.gov (United States)

    Gesase, Samwel; Gosling, Roly D; Hashim, Ramadhan; Ord, Rosalynn; Naidoo, Inbarani; Madebe, Rashid; Mosha, Jacklin F; Joho, Angel; Mandia, Victor; Mrema, Hedwiga; Mapunda, Ephraim; Savael, Zacharia; Lemnge, Martha; Mosha, Frank W; Greenwood, Brian; Roper, Cally; Chandramohan, Daniel

    2009-01-01

    Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in infants (IPTi). High levels of drug resistance to SP have been reported from north-eastern Tanzania associated with mutations in parasite genes. This study compared the in vivo efficacy of SP in symptomatic 6-59 month children with uncomplicated malaria and in asymptomatic 2-10 month old infants. An open label single arm (SP) standard 28 day in vivo WHO antimalarial efficacy protocol was used in 6 to 59 months old symptomatic children and a modified protocol used in 2 to 10 months old asymptomatic infants. Enrolment was stopped early (87 in the symptomatic and 25 in the asymptomatic studies) due to the high failure rate. Molecular markers were examined for recrudescence, re-infection and markers of drug resistance and a review of literature of studies looking for the 581G dhps mutation was carried out. In symptomatic children PCR-corrected early treatment failure was 38.8% (95% CI 26.8-50.8) and total failures by day 28 were 82.2% (95% CI 72.5-92.0). There was no significant difference in treatment failures between asymptomatic and symptomatic children. 96% of samples carried parasites with mutations at codons 51, 59 and 108 in the dhfr gene and 63% carried a double mutation at codons 437 and 540. 55% carried a third mutation with the addition of a mutation at codon 581 in the dhps gene. This triple: triple haplotype maybe associated with earlier treatment failure. In northern Tanzania SP is a failed drug for treatment and its utility for prophylaxis is doubtful. The study found a new combination of parasite mutations that maybe associated with increased and earlier failure. ClinicalTrials.gov NCT00361114.

  8. Generation of a High Resistance in vitro Blood-Brain-Barrier Model and Investigations of Brain-to-Blood Glutamate Efflux

    DEFF Research Database (Denmark)

    Helms, Hans Christian

    Blod-hjernebarrieren (blood-brain barrier, BBB) opretholder den generelle homeostase i hjernens væsker. BBB kan også spille en rolle i homeostasen for den eksitatoriske aminosyre, L-glutamat. In vitro modeller kan være effektive værktøjer til at få mekanistiske informationer om transcellulær...... transport. De fleste in vitro modeller mangler dog funktionelle tight junctions. Dette projekt indeholder to underprojekter med målene; etabler og karakteriser en BBB model bestående af endothelceller fra kalvehjerner dyrket i co-kultur med rotte astrocytter og undersøg, hvordan tight junction...

  9. High Resistant Sand Injected Marl and Low Resistant Damaged Marl to Locate and Characterize the Thénia Fault Zone in Boumerdes City (North-Central Algeria)

    Science.gov (United States)

    Moulouel, Hakim; Bensalem, Rabah; Machane, Djamel; Bendaoud, Abderrahmane; Gharbi, Sofiane; Oubaiche, El-Hadi; Ousalem, Hassane; Skendri, Walid

    2017-01-01

    The purpose of this study was to locate and characterize the Thénia Fault Zone (TFZ) in the urban area of Boumerdes city; geological and electrical resistivity tomography surveys have targeted the Plaisancian marl and its Quaternary cover. As a whole, data indicate a complex near-vertical fault zone with an asymmetric and zoned internal structure of at least 150 m wide and with a straight N120° overall trending. The fault zone is traversed with two elongated parallel fault branches (FB1 and FB2), generally, 70 m distant from each other. These fault branches locate two intense damage zones (IDZs) of 10-15 m thick each, situated at the margin of two damage zones each having a thickness of several tens of meters. Downward sand injections into IDZs during Pleistocene epoch, possible pulverization of Plaisancian marl rocks, systematic deflection of actual stream channels, and vertical displacement of at least 30 m affecting Quaternary alluvial deposits show that the area would have undergone active tectonic driven by the TFZ.

  10. IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

    DEFF Research Database (Denmark)

    Saaby, Lasse; Helms, Hans Christian Cederberg; Brodin, Birger

    2016-01-01

    line, IPEC-J2 MDR1, retained its high transepithelilal resistance (>15,000 Ω·cm(2)), which translated into low permeability of the small hydrophilic tracer, mannitol (P diazepam, displayed high permeability resulting in a dynamic range of 1500 (PDiazepam...

  11. Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: an independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors.

    Science.gov (United States)

    Talbot, Annie; Grant, Philip; Taylor, Jonathan; Baril, Jean-Guy; Liu, Tommy Fulisma; Charest, Hugues; Brenner, Bluma; Roger, Michel; Shafer, Robert; Cantin, Régis; Zolopa, Andrew

    2010-06-01

    Genotypic interpretation systems (GISs) for darunavir and tipranavir susceptibility are rarely tested by the use of independent data sets. The virtual phenotype (the phenotype determined by Virco [the "Vircotype"]) was used to interpret all genotypes in Québec, Canada, and phenotypes were determined for isolates predicted to be resistant to all protease inhibitors other than darunavir and tipranavir. We used multivariate analyses to predict relative phenotypic susceptibility to darunavir and tipranavir. We compared the performance characteristics of the Agence Nationale de Recherche sur le Sida scoring algorithm, the Stanford HIV database scoring algorithm (with separate analyses of the discrete and numerical scores), the Vircotype, and the darunavir and tipranavir manufacturers' scores for prediction of the phenotype. Of the 100 isolates whose phenotypes were determined, 89 and 72 were susceptible to darunavir and tipranavir, respectively. In multivariate analyses, the presence of I84V and V82T and the lack of L10F predicted that the isolates would be more susceptible to darunavir than tipranavir. The presence of I54L, V32I, and I47V predicted that the isolates would be more susceptible to tipranavir. All GISs except the system that provided the Stanford HIV database discrete score performed well in predicting the darunavir resistance phenotype (R(2) = 0.61 to 0.69); the R(2) value for the Stanford HIV database discrete scoring system was 0.38. Other than the system that provided the Vircotype (R(2) = 0.80), all GISs performed poorly in predicting the tipranavir resistance phenotype (R(2) = 0.00 to 0.31). In this independent cohort harboring highly protease inhibitor-resistant HIV isolates, reduced phenotypic susceptibility to darunavir and tipranavir was rare. Generally, GISs predict susceptibility to darunavir substantially better than they predict susceptibility to tipranavir.

  12. [Prevalence of Enterococcus faecalis and Enterococcus faecium with high resistance to aminoglycosides in the cities of Resistencia and Corrientes, Republic of Argentina].

    Science.gov (United States)

    Ronconi, M C; Merino, L A

    2000-02-01

    The objective of this study was characterize the prevalence of high-level aminoglycosides resistance (HLRA) in Enterococcus faecalis and E. faecium, determine the relationship between high-level gentamicin resistance (HLGR) and other aminoglycosides, and their distribution according clinical samples (blood, urine and others). A total of 177 strain (157 E. faecalis and 20 E. faecium) isolated from 1996 to 1998 were studied. They were identified by using classic methods. Their susceptibility to gentamicin, streptomycin, and kanamycin was tested by the disk diffusion technique using high-level disks in agar Müller Hinton. E. faecalis showed HLRG of 28.7%, streptomycin 28.7% and kanamycin 37.6%, E. faecium showed 50%, 40%, and 60% respectively. The strains with HLRA have a tendency to high-level resistances to streptomycin and kanamycin (p < 0.0005). Statistical analysis demonstrated significative differences among strains with HLRA isolated from blood, urine and other clinical samples (p < 0.0005 to gentamicin and streptomycin and 0.004 < p < 0.007 to kanamycin). The prevalence of HLRA enterococci found in the area os this study, justify its detection, particularity in cases of serious infections.

  13. Comparative Digital Gene Expression Analysis of Tissue-Cultured Plantlets of Highly Resistant and Susceptible Banana Cultivarsin Response to Fusarium oxysporum

    Directory of Open Access Journals (Sweden)

    Yuqing Niu

    2018-01-01

    Full Text Available Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc is one of the most destructive soil-borne diseases. In this study, young tissue-cultured plantlets of banana (Musa spp. AAA cultivars differing in Foc susceptibility were used to reveal their differential responses to this pathogen using digital gene expression (DGE. Data were evaluated by various bioinformatic tools (Venn diagrams, gene ontology (GO annotation and Kyoto encyclopedia of genes and genomes (KEGG pathway analyses and immunofluorescence labelling method to support the identification of gene candidates determining the resistance of banana against Foc. Interestingly, we have identified MaWRKY50 as an important gene involved in both constitutive and induced resistance. We also identified new genes involved in the resistance of banana to Foc, including several other transcription factors (TFs, pathogenesis-related (PR genes and some genes related to the plant cell wall biosynthesis or degradation (e.g., pectinesterases, β-glucosidases, xyloglucan endotransglucosylase/hydrolase and endoglucanase. The resistant banana cultivar shows activation of PR-3 and PR-4 genes as well as formation of different constitutive cell barriers to restrict spreading of the pathogen. These data suggest new mechanisms of banana resistance to Foc.

  14. Conventional P-ω/Q-V Droop Control in Highly Resistive Line of Low-Voltage Converter-Based AC Microgrid

    Directory of Open Access Journals (Sweden)

    Xiaochao Hou

    2016-11-01

    Full Text Available In low-voltage converter-based alternating current (AC microgrids with resistive distribution lines, the P-V droop with Q-f boost (VPD/FQB is the most common method for load sharing. However, it cannot achieve the active power sharing proportionally. To overcome this drawback, the conventional P-ω/Q-V droop control is adopted in the low-voltage AC microgrid. As a result, the active power sharing among the distributed generators (DGs is easily obtained without communication. More importantly, this study clears up the previous misunderstanding that conventional P-ω/Q-V droop control is only applicable to microgrids with highly inductive lines, and lays a foundation for the application of conventional droop control under different line impedances. Moreover, in order to guarantee the accurate reactive power sharing, a guide for designing Q-V droop gains is given, and virtual resistance is adopted to shape the desired output impedance. Finally, the effects of power sharing and transient response are verified through simulations and experiments in converter-based AC Microgrid.

  15. Reformulating cereal bars: high resistant starch reduces in vitro digestibility but not in vivo glucose or insulin response; whey protein reduces glucose but disproportionately increases insulin.

    Science.gov (United States)

    Wolever, Thomas Ms; van Klinken, B Jan-Willem; Bordenave, Nicolas; Kaczmarczyk, Melissa; Jenkins, Alexandra L; Chu, YiFang; Harkness, Laura

    2016-10-01

    Resistant starch (RS) and whey protein are thought to be effective nutrients for reducing glycemic responses. We aimed to determine the effect of varying the sucrose, RS, and whey protein content of cereal bars on glucose and insulin responses. Twelve healthy subjects [mean ± SD age: 36 ± 12 y; mean ± SD body mass index (in kg/m(2)): 24.9 ± 2.7] consumed 40 g available-carbohydrate (avCHO) portions of 5 whole-grain cereal bars that contained varying amounts of RS and whey protein concentrate [WPC; 70% protein; RS:WPC, %wt:wt: 15:0 (Bar15/0); 15:0, low in sucrose (Bar15/0LS); 15:5 (Bar15/5); 10:5 (Bar10/5); and 10:10 (Bar10/10)] and 2 portion sizes of a control bar low in whole grains, protein, and RS [control 1 contained 40 g avCHO (Control1); control 2 contained total carbohydrate equal to Bar15/0LS (Control2)] on separate days by using a randomized crossover design. Glucose and insulin responses in vivo and carbohydrate digestibility in vitro were measured over 3 h. Incremental area under the curve (iAUC) over 0-3 h for glucose (min × mmol/L) differed significantly between treatments (P digested in vitro ∼30% more slowly than the control bars (P digestibility in vitro. Glucose and insulin responses elicited by high-RS, whey protein-free bars were similar to those elicited from control bars. The inclusion of RS in cereal bar formulations did not reduce glycemic responses despite slower starch digestion in vitro. Thus, caution is required when extrapolating in vitro starch digestibility to in vivo glycemic response. The inclusion of whey protein in cereal bar formulations to reduce glycemic response requires caution because this may be associated with a disproportionate increase in insulin as judged by an increased insulin-to-glucose iAUC ratio. This trial was registered at clinicaltrials.gov as NCT02537587. © 2016 American Society for Nutrition.

  16. Test beam measurement of ams H35 HV-CMOS capacitively coupled pixel sensor prototypes with high-resistivity substrate arXiv

    CERN Document Server

    Benoit, M.; Casanova, R.; Cavallaro, E.; Chen, H.; Chen, K.; Di Bello, F.A.; Ferrere, D.; Frizzell, D.; Golling, T.; Gonzalez-Sevilla, S.; Grinstein, S.; Iacobucci, G.; Kiehn, M.; Lanni, F.; Liu, H.; Metcalfe, J.; Meng, L.; Merlassino, C.; Miucci, A.; Muenstermann, D.; Nessi, M.; Okawa, H.; Perić, I.; Rimoldi, M.; Ristić, B.; Sultan, D M S; Terzo, S.; Vicente Barrero Pinto, M.; Vilella Figueras, E.; Weber, M.; Weston, T.; Wu, W.; Xie, J.; Xu, L.; Zaffaroni, E.; Zhang, M.

    In the context of the studies of the ATLAS High Luminosity LHC programme, radiation tolerant pixel detectors in CMOS technologies are investigated. To evaluate the effects of substrate resistivity on CMOS sensor performance, the H35DEMO demonstrator, containing different diode and amplifier designs, was produced in ams H35 HV-CMOS technology using four different substrate resistivities spanning from $\\mathrm{80}$ to $\\mathrm{1000~\\Omega \\cdot cm}$. A glueing process using a high-precision flip-chip machine was developed in order to capacitively couple the sensors to FE-I4 Readout ASIC using a thin layer of epoxy glue with good uniformity over a large surface. The resulting assemblies were measured in beam test at the Fermilab Test Beam Facilities with 120 GeV protons and CERN SPS H8 beamline using 80 GeV pions. The in-time efficiency and tracking properties measured for the different sensor types are shown to be compatible with the ATLAS ITk requirements for its pixel sensors.

  17. Structural properties and parameters of epitaxial silicon carbide films, grown by atomic substitution on the high-resistance (111) oriented silicon

    Science.gov (United States)

    Kukushkin, S. A.; Nussupov, K. Kh.; Osipov, A. V.; Beisenkhanov, N. B.; Bakranova, D. I.

    2017-11-01

    The structure, composition and physical parameters of multilayer silicon carbide system synthesized by atom substitution method on the surface of low-dislocation single-crystal (111) oriented silicon were studied by Raman spectroscopy, ellipsometry, X-ray reflectometry, electron diffraction, IR spectroscopy, X-ray diffraction, AFM and profilometry. It was revealed that SiC films consist of layers, differing in SiyC composition, structure and thickness. The upper layers is a single-crystal 3C-SiC and the lower layers lying in depth of the substrate contain silicon carbide nanocrystals with a high degree of structure perfection and average size of 3-7 nm capable of preferential orientation (311), as well as large crystals (60-260 μm). The presence of cubic (3C-SiC) and hexagonal (mainly, 2H-SiC) polytypes with largest content of crystalline SiC phases in films with the composition closest to stoichiometric was established. In all samples there is carbon in super stoichiometric state, and its structure depends on the synthesis conditions.

  18. Impairment of the class IIa bacteriocin receptor function and membrane structural changes are associated to enterocin CRL35 high resistance in Listeria monocytogenes.

    Science.gov (United States)

    Masias, Emilse; Dupuy, Fernando G; da Silva Sanches, Paulo Ricardo; Farizano, Juan Vicente; Cilli, Eduardo; Bellomio, Augusto; Saavedra, Lucila; Minahk, Carlos

    2017-07-01

    Enterocin CRL35 is a class IIa bacteriocin with anti-Listeria activity. Resistance to these peptides has been associated with either the downregulation of the receptor expression or changes in the membrane and cell walls. The scope of the present work was to characterize enterocin CRL35 resistant Listeria strains with MICs more than 10,000 times higher than the MIC of the WT sensitive strain. Listeria monocytogenes INS7 resistant isolates R2 and R3 were characterized by 16S RNA gene sequencing and rep-PCR. Bacterial growth kinetic was studied in different culture media. Plasma membranes of sensitive and resistant bacteria were characterized by FTIR and Langmuir monolayer techniques. The growth kinetic of the resistant isolates was slower as compared to the parental strain in TSB medium. Moreover, the resistant isolates barely grew in a glucose-based synthetic medium, suggesting that these cells had a major alteration in glucose transport. Resistant bacteria also had alterations in their cell wall and, most importantly, membrane lipids. In fact, even though enterocin CRL35 was able to bind to the membrane-water interface of both resistant and parental sensitive strains, this peptide was only able to get inserted into the latter membranes. These results indicate that bacteriocin receptor is altered in combination with membrane structural modifications in enterocin CRL35-resistant L. monocytogenes strains. Highly enterocin CRL35-resistant isolates derived from Listeria monocytogenes INS7 have not only an impaired glucose transport but also display structural changes in the hydrophobic core of their plasma membranes. Copyright © 2017. Published by Elsevier B.V.

  19. Effect of Coleus tuberosus Flour High Resistant Starch Consumption in Glucose, Lipid, Digest and Short Chain Fatty Acid Profile in Normal Rats

    OpenAIRE

    Mutiara Nugraheni; Siti Hamidah; Windarwati

    2015-01-01

    This research was conducted to study the effect of processing methods on the resistant starch content of Coleus tuberosus and the influence of consumption of Coleus tuberosus flour toward profiles of glucose, lipids (total cholesterol, triglycerides, LDL, HDL), digest and Short Chain Fatty Acids (SCFA) in normal rats. Processing method affects the levels of resistant starch in the Coleus tuberosus starch. The results showed the levels of resistant starch of Coleus tuberosus with different pro...

  20. C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir

    Science.gov (United States)

    Aoki, Manabu; Hayashi, Hironori; Yedidi, Ravikiran S.; Martyr, Cuthbert D.; Takamatsu, Yuki; Aoki-Ogata, Hiromi; Nakamura, Teruya; Nakata, Hirotomo; Das, Debananda; Yamagata, Yuriko; Ghosh, Arun K.

    2015-01-01

    ABSTRACT We identified three nonpeptidic HIV-1 protease inhibitors (PIs), GRL-015, -085, and -097, containing tetrahydropyrano-tetrahydrofuran (Tp-THF) with a C-5 hydroxyl. The three compounds were potent against a wild-type laboratory HIV-1 strain (HIV-1WT), with 50% effective concentrations (EC50s) of 3.0 to 49 nM, and exhibited minimal cytotoxicity, with 50% cytotoxic concentrations (CC50) for GRL-015, -085, and -097 of 80, >100, and >100 μM, respectively. All the three compounds potently inhibited the replication of highly PI-resistant HIV-1 variants selected with each of the currently available PIs and recombinant clinical HIV-1 isolates obtained from patients harboring multidrug-resistant HIV-1 variants (HIVMDR). Importantly, darunavir (DRV) was >1,000 times less active against a highly DRV-resistant HIV-1 variant (HIV-1DRVRP51); the three compounds remained active against HIV-1DRVRP51 with only a 6.8- to 68-fold reduction. Moreover, the emergence of HIV-1 variants resistant to the three compounds was considerably delayed compared to the case of DRV. In particular, HIV-1 variants resistant to GRL-085 and -097 did not emerge even when two different highly DRV-resistant HIV-1 variants were used as a starting population. In the structural analyses, Tp-THF of GRL-015, -085, and -097 showed strong hydrogen bond interactions with the backbone atoms of active-site amino acid residues (Asp29 and Asp30) of HIV-1 protease. A strong hydrogen bonding formation between the hydroxyl moiety of Tp-THF and a carbonyl oxygen atom of Gly48 was newly identified. The present findings indicate that the three compounds warrant further study as possible therapeutic agents for treating individuals harboring wild-type HIV and/or HIVMDR. IMPORTANCE Darunavir (DRV) inhibits the replication of most existing multidrug-resistant HIV-1 strains and has a high genetic barrier. However, the emergence of highly DRV-resistant HIV-1 strains (HIVDRVR) has recently been observed in vivo and in vitro. Here, we identified three novel HIV-1 protease inhibitors (PIs) containing a tetrahydropyrano-tetrahydrofuran (Tp-THF) moiety with a C-5 hydroxyl (GRL-015, -085, and -097) which potently suppress the replication of HIVDRVR. Moreover, the emergence of HIV-1 strains resistant to the three compounds was considerably delayed compared to the case of DRV. The C-5 hydroxyl formed a strong hydrogen bonding interaction with the carbonyl oxygen atom of Gly48 of protease as examined in the structural analyses. Interestingly, a compound with Tp-THF lacking the hydroxyl moiety substantially decreased activity against HIVDRVR. The three novel compounds should be further developed as potential drugs for treating individuals harboring wild-type and multi-PI-resistant HIV variants as well as HIVDRVR. PMID:26581995

  1. Conventional P-ω/Q-V Droop Control in Highly Resistive Line of Low-Voltage Converter-Based AC Microgrid

    DEFF Research Database (Denmark)

    Hou, Xiaochao; Sun, Yao; Yuan, Wenbin

    2016-01-01

    -ω/Q-V droop control is adopted in the low-voltage AC microgrid. As a result, the active power sharing among the distributed generators (DGs) is easily obtained without communication. More importantly, this study clears up the previous misunderstanding that conventional P-ω/Q-V droop control is only applicable...

  2. Myxomatosis: the virulence of field strains of myxoma virus in a population of wild rabbits (Oryctolagus cuniculus L.) with high resistance to myxomatosis.

    Science.gov (United States)

    Edmonds, J W; Nolan, I F; Shepherd, R C; Gocs, A

    1975-06-01

    The virulence of field strains of myxoma virus is increasing in the Mallee region of Victoria where the resistance of the rabbit to myxomatosis is high. This suggests that the climax association will be a moderately severe disease.

  3. Characterization of the endosperm starch and the pleiotropic effects of biosynthetic enzymes on their properties in novel mutant rice lines with high resistant starch and amylose content.

    Science.gov (United States)

    Itoh, Yuuki; Crofts, Naoko; Abe, Misato; Hosaka, Yuko; Fujita, Naoko

    2017-05-01

    Resistant starch (RS) is beneficial to human health. In order to reduce the current prevalence of diabetes and obesity, several transgenic and mutant crops containing high RS content are being developed. RS content of steamed rice with starch-branching enzyme (BE)IIb-deficient mutant endosperms is considerably high. To understand the mechanisms of RS synthesis and to increase RS content, we developed novel mutant rice lines by introducing the gene encoding starch synthase (SS)IIa and/or granule-bound starch synthase (GBSS)I from an indica rice cultivar into a japonica rice-based BEIIb-deficient mutant line, be2b. Introduction of SSIIa from an indica rice cultivar produced higher levels of amylopectin chains with degree of polymerization (DP) 11-18 than those in be2b; the extent of the change was slight due to the shortage of donor chains for SSIIa (DP 6-12) owing to BEIIb deficiency. The introduction of GBSSI from an indica rice cultivar significantly increased amylose content (by approximately 10%) in the endosperm starch. RS content of the new mutant lines was the same as or slightly higher than that of the be2b parent line. The relationship linking starch structure, RS content, and starch biosynthetic enzymes in the new mutant lines has also been discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Expression of cry2Ah1 and two domain II mutants in transgenic tobacco confers high resistance to susceptible and Cry1Ac-resistant cotton bollworm.

    Science.gov (United States)

    Li, Shengyan; Wang, Zeyu; Zhou, Yiyao; Li, Changhui; Wang, Guiping; Wang, Hai; Zhang, Jie; Liang, Gemei; Lang, Zhihong

    2018-01-11

    To improve the novel Bacillus thuringiensis insecticidal gene cry2Ah1 toxicity, two mutants cry2Ah1-vp (V354VP) and cry2Ah1-sp (V354SP) were performed. SWISS-MODEL analysis showed two mutants had a longer loop located between β-4 and β-5 of domain II, resulting in higher binding affinity with brush border membrane vesicles (BBMV) of Helicoverpa armigera comparing with Cry2Ah1. The cry2Ah1, cry2Ah1-vp, and cry2Ah1-sp were optimized codon usage according to plant codon bias, and named mcry2Ah1, mcry2Ah1-vp, and mcry2Ah1-sp. They were transformed into tobacco via Agrobacterium-mediated transformation and a total of 4, 8, and 24 transgenic tobacco plants were obtained, respectively. The molecular detection showed the exogenous gene was integrated into tobacco genome, and successfully expressed at the transcript and translation levels. Cry2Ah1 protein in transgenic tobacco plants varied from 4.41 to 40.28 μg g -1 fresh weight. Insect bioassays indicated that all transgenic tobacco plants were highly toxic to both susceptible and Cry1Ac-resistant cotton bollworm larvae, and the insect resistance efficiency to Cry1Ac-resistant cotton bollworm was highest in mcry2Ah1-sp transgenic tobacco plants. The results demonstrated that cry2Ah1 was a useful Bt insecticidal gene to susceptible and Cry1Ac-resistant cotton bollworm and had potential application for insect biocontrol and as a candidate for pyramid strategy in Bt crops.

  5. S-N Curves of high resistance steels in the gigacyclic regime; Curvas S-N de aceros de alta resistencia dentro del regimen gigaciclico

    Energy Technology Data Exchange (ETDEWEB)

    Marinez G, I [Conservatoire National des Arts et Metiers-Institut des Technologies et des Materiaux Avances (CNAM-ITMA), Paris (France); Dominguez A, G [Instituto Tecnologico de Celaya, Guanajuato (Mexico); Bathias, C [Conservatoire National des Arts et Metiers-Institut des Technologies et des Materiaux Avances (CNAM-ITMA), Paris (France)

    2004-04-15

    In this paper, the fatigue behavior of high strength steel used for mechanical parts has been investigated in the gigacycle fatigue regime. An experimental study has been carried out with both: R = 0.1 (perlitic-ferritic steel) and R = -1 (perlitic-ferritic steel, bainitic steel, martensitic steels) loads, at a high frequency of 20 khz up to 1010 cycles, to determine the S-N curves when fatigue life is more than 107 cycles. Comparison of experimental results at frequencies of 20 khz and 30 Hz with R = -1, shows that the S-N curve has a good agreement between 105 and 107 cycles for the high strength steels, Furthermore, fracture surface observations are made by SEM; the transition of crack initiation site is described. The generalization of gigacycle fatigue behavior is analyzed. More often initiation of fatigue crack at 109 cycles is a bulk phenomenon with an important effect of stress concentration due to mineral inclusions or perlitic platelets. Thus, the Murakami model is efficient when we can measure the defects associated with fracture, but it can not take into account the microstructure effect related to platelets phenomenon. [Spanish] En este trabajo se investigo el comportamiento en fatiga gigaciclica de varios aceros de alta resistencia utilizados en la industria automotriz. El estudio experimental se llevo a cabo utilizando dos diferentes valores de carga: R = 0.1 (acero perlitoferritico) y R = -1 (acero perlito-ferritico, acero bainitico, aceros martensiticos), a una frecuencia de ensayo de 20 kHz y hasta 1010 ciclos, para determinar las curvas S-N arriba de 107 ciclos. La comparacion de resultados experimentales obtenidos utilizando frecuencias de ensayo de 20 kHz y 30 Hz con la relacion de carga R = - 1, muestran la continuidad de las curvas S-N entre 105 y 107 ciclos para estos aceros de alta resistencia. Por otro lado, observaciones de la superficie de fractura se efectuaron utilizando el microscopio electronico de barrido; se describe la transicion del sitio de fractura. Las generalidades de la fatiga gigaciclica se analizan. Frecuentemente, la iniciacion de la ruptura en fatiga a 109 ciclos es un fenomeno de volumen con un importante efecto de la concentracion de esfuerzos debido a las inclusiones no metalicas o a las laminas de perlita. Asi, el modelo de Murakami es eficiente si podemos medir los defectos asociados con la fractura, pero no toma en cuenta los efectos en la microestructura relacionados con las laminas cristalograficas.

  6. Effects of rumen-protected Capsicum oleoresin on productivity and responses to a glucose tolerance test in lactating dairy cows.

    Science.gov (United States)

    Oh, J; Harper, M; Giallongo, F; Bravo, D M; Wall, E H; Hristov, A N

    2017-03-01

    The objective of this experiment was to investigate the effects of rumen-protected Capsicum oleoresin (RPC) supplementation on feed intake, milk yield and composition, nutrient utilization, fecal microbial ecology, and responses to a glucose tolerance test in lactating dairy cows. Nine multiparous Holstein cows were used in a replicated 3 × 3 Latin square design balanced for residual effects with three 28-d periods. Each period consisted of 14 d for adaptation and 14 d for data collection and sampling. Treatments were 0 (control), 100, and 200 mg of RPC/cow per day. They were mixed with a small portion of the total mixed ration and top-dressed. Glucose tolerance test was conducted once during each experimental period by intravenous administration of glucose at a rate of 0.3 g/kg of body weight. Dry matter intake was not affected by RPC. Milk yield tended to increase for RPC treatments compared to the control. Feed efficiency was linearly increased by RPC supplementation. Concentrations of fat, true protein, and lactose in milk were not affected by RPC. Apparent total-tract digestibility of dry matter, organic matter, and crude protein was linearly increased, and fecal nitrogen excretion was linearly decreased by RPC supplementation. Rumen-protected Capsicum oleoresin did not affect the composition of fecal bacteria. Glucose concentration in serum was not affected by RPC supplementation post glucose challenge. However, compared to the control, RPC decreased serum insulin concentration at 5, 10, and 40 min post glucose challenge. The area under the insulin concentration curve was also decreased 25% by RPC. Concentration of nonesterified fatty acids and β-hydroxybutyrate in serum were not affected by RPC following glucose administration. In this study, RPC tended to increase milk production and increased feed efficiency in dairy cows. In addition, RPC decreased serum insulin concentration during the glucose tolerance test, but glucose concentration was not affected

  7. Comparison of performance of partial prestressed beam-column subassemblages made of reactive powder concrete and normal concrete materials using finite element models

    Science.gov (United States)

    Nurjannah, S. A.; Budiono, B.; Imran, I.; Sugiri, S.

    2016-04-01

    Research on concrete material continues in several countries and had produced a concrete type of Ultra High Performance Concrete (UHPC) which has a better compressive strength, tensile strength, flexural strength, modulus of elasticity, and durability than normal concrete (NC) namely Reactive Powder Concrete (RPC). Researches on structures using RPC material showed that the RPC structures had a better performance than the NC structures in resisting gravity and lateral cyclic loads. In this study, an experiment was conducted to apply combination of constant axial and lateral cyclic loads to a prototype of RPC interior partial prestressed beam-column subassemblage (prototype of BCS-RPC) with a value of Partial Prestressed Ratio (PPR) of 31.72% on the beam. The test results were compared with finite element model of beam-column subassemblage made of RPC by PPR of 31.72% (BCS-RPC-31.72). Furthermore, there was BCS-RPC modeling with PPR of 21.39% (BCS-RPC-21.39) and beam-column subassemblages made of NC materials modeling with a value of PPR at 21.09% (BCS-NC-21.09) and 32.02% (BCS-NC-32.02). The purpose of this study was to determine the performance of the BCS-RPC models compared to the performance of the BCS-NC models with PPR values below and above 25%, which is the maximum limit of permitted PPR. The results showed that all models of BCS-RPC had a better performance than all models of BCS-NC and the BCS-RPC model with PPR above 25% still behaved ductile and was able to dissipate energy well.

  8. A Recursive Formulation of Cholesky Factorization of a Matrix in Packed Storage Format

    DEFF Research Database (Denmark)

    Andersen, Bjarne Stig; Gustavson, Fred; Wasniewski, Jerzy

    2001-01-01

    . Algorithm RPC is based on level-3 BLAS and requires variants of algorithms {\\$\\backslash\\$bf TRSM} and {\\$\\backslash\\$bf SYRK} that work on RPF. We call these {\\$\\backslash\\$bf RP\\$\\backslash\\$\\_TRSM} and {\\$\\backslash\\$bf RP\\$\\backslash\\$\\_SYRK} and find that they do most of their work by calling...... matrix. Second, RPC gives a level-3 implementation of Cholesky factorization whereas standard packed implementations are only level 2. Hence, the performance of our RPC implementation is decidedly superior. Third, unlike fixed block size algorithms, RPC requires no block size tuning parameter. We present...

  9. VT Boundaries - LEPC polygons

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  10. VT Boundaries - village polygons

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  11. VT Boundaries - town polygons

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  12. VT Boundaries - all lines

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  13. Oyster investigations in the Northumberland Strait Region of New Brunswick. Vol.1 The nature of the growing area and the distribution of oysters: Études relatives aux huîtres dans la region du détroit de Northumberland. : Vol.1 Étude de la distribution des huîtres et de certains paramétres dans les zones de culture

    National Research Council Canada - National Science Library

    Bacon, G.B

    1977-01-01

    .... In essence RPC was commissionned to investigate, on a comparative basis, hydrographic conditions, water chemistry, substrate characteristics, plankton assemblages and oyster populations in Bay du Vin...

  14. VT Boundaries - state polygon

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  15. VT Boundaries - county polygons

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The BNDHASH dataset depicts Vermont villages, towns, counties, Regional Planning Commissions (RPC), and LEPC (Local Emergency Planning Committee)...

  16. Dicty_cDB: Contig-U15526-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FG146748 ) AGN_RPC008xj05f1.ab1 AGN_RPC Nicotiana tabacum cD... 72 4e-15 4 ( FG164124 ) AGN_RNC013x...16 ) AGN_RNC018xn11f1.ab1 AGN_RNC Nicotiana tabacum cD... 72 9e-14 3 ( FG164274 ) AGN_RNC013xj01f1.ab1 AGN_R...cD... 64 4e-12 3 ( FG145209 ) AGN_RPC013xh01f1.ab1 AGN_RPC Nicotiana tabacum cD... 64 5e-12 3 ( FG145867 ) A

  17. Differences in antioxidant activity between two rice protein concentrates in an oil-in-water emulsion

    Science.gov (United States)

    Two formulations of rice protein concentrates (RPC) derived from brown rice were evaluated for their antioxidant activity in bulk oil and in oil-in-water emulsions. Bulk oils were mixed with RPC and heated to 180°C, and total polar compounds and triacylglycerol polymerization were measured. Minimal ...

  18. Perilaku Histeretik Subassemblage Balok-Kolom Interior Prategang Parsial Reactive Powder Concrete dalam Pemodelan Finite Element

    Directory of Open Access Journals (Sweden)

    Siti Aisyah Nurjannah

    2015-12-01

    Full Text Available Research on concrete in some countries has produced a concrete type of Ultra High Performance Concrete (UHPC which has the strength, ductility, modulus of elasticity, and high durability, namely Reactive Powder Concrete (RPC. Research on structural engineering using RPC material in various countries have shown better performance than structures made of Normal Concrete (NC or High Performance Concrete (HPC in resisting both monotonic and cyclic loads. Research showed that structures using RPC that resisted cyclic loading had an appropriate hysteretic performance. In this study, research was conducted using RPC material and structure modeling with non-linear finite element method (NL-FEM. The material test results were used as parts of the input of the interior partial prestressed beam-column subassemblage structures (S-RPC modelled using the NL-FEM. As a comparison, there were models of interior partial prestressed beam-column subassemblage used NC materials (S-NC. To analyze the hysteretic behavior of the models, there were variations of Partial Prestressed Ratio (PPR values of S-RPC and S-NC models. Analysis of modeling results showed superior performance and better hysteretic behavior of all S-RPC models compared with the S-NC models in terms of ductility, energy dissipation, stiffness, and strength. From the modeling results, there were optimum PPR values of the S-RPC models which ranged between 21.39% and 37.34%. Meanwhile, the optimum PPR value of S-NC model was 34.15%.

  19. Gclust Server: 111488 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available CME_CMK059C Cluster Sequences - 383 RNA polymerase I, III common subunit: RPC40 1 1.00e+00 14.29 0.0 0.0 0.0 0.0...Representative annotation RNA polymerase I, III common subunit: RPC40 Number of Sequences 1 Homologs 1

  20. Mesoproterozoic evolution of the Rio de la Plata Craton in Uruguay: at the heart of Rodinia?

    DEFF Research Database (Denmark)

    Gaucher, Claudio; Frei, Robert; Chemale, Farid

    2011-01-01

    Mesoproterozoic volcanosedimentary units and tectonic events occurring in the Ri´o de la Plata Craton (RPC) are reviewed. A belt consisting of volcanosedimentary successions exhibiting greenschist-facies metamorphism is exposed in the eastern RPC (Nico Pe´rez Terrane) in Uruguay. The Parque UTE G...

  1. Proving the correctness of client/server software

    Indian Academy of Sciences (India)

    , formal specification and verification of RPC mechanisms is a prerequisite for the verification of any such software. In this paper, we present a mathematical specification of an RPC mechanism and we outline how to prove the correctness of an ...

  2. Effect of rumen-protected choline supplementation on liver and adipose gene expression during the transition period in dairy cattle

    NARCIS (Netherlands)

    Goselink, R.M.A.; Baal, van J.; Widjaja, H.C.A.; Dekker, R.A.; Zom, R.L.G.; Veth, M.J.; Vuuren, van A.M.

    2013-01-01

    We previously reported that supplementation of rumen-protected choline (RPC) reduces the hepatic triacylglycerol concentration in periparturient dairy cows during early lactation. Here, we investigated the effect of RPC on the transcript levels of lipid metabolism-related genes in liver and adipose

  3. Sample introduction systems for reversed phase LC-ICP-MS of selenium using large amounts of methanol - comparison of systems based on membrane desolvation, a spray chamber and direct injection

    DEFF Research Database (Denmark)

    Bendahl, L.; Gammelgaard, Bente

    2005-01-01

    . The independence of the signal from the methanol concentration in the eluent allowed quanti. cation of human selenoprotein P isoforms by gradient microbore reversed phase chromatography (mu RPC) on the basis of an internal trimethylselenonium standard. The MCN-MD system was applied for mu RPC analysis of Se-77...

  4. Gclust Server: 181985 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 181985 Rpa3_RPC_3931 Cluster Sequences - 378 hypothetical protein 1 1.00e-99 0.0 0....0 0.0 6.67 0.0 0.0 Show 181985 Cluster ID 181985 Sequence ID Rpa3_RPC_3931 Link to cluster sequences Cluster

  5. Natural Exposure

    CERN Document Server

    2002-01-01

    Description of programs implemented by Radiation Protection Centre is presented. In 2001 RPC started measurements of indoor radon concentrations in the regions of higher radon risk. In 2002 radon risk assessments in some parts of Panevezys city was performed. Radon concentrations in in soil air and soil were measured. RPC implements study assessing the doses received by air crew members of Lithuanian Airlines.

  6. Programs and Expertise

    CERN Document Server

    2001-01-01

    Description of programs and expertise implemented by Radiation Protection Centre is presented. RPC implements study assessing the doses received by air crew members of Lithuanian Airlines. In 2001 RPC started measurements of indoor radon concentrations in the houses of regions with karst formations, commenced new program analyzing amounts of radionuclides in typical diet of hospital patients.

  7. Folate, vitamin B12, alpha-tocopherol and selected liver components in periparturient dairy goats supplemented with choline and vitamin E

    Directory of Open Access Journals (Sweden)

    V. Dell'Orto

    2010-04-01

    Full Text Available The influence of rumen-protected choline and vitamin E administration on status of folate, vitamin B12, and vitamin E and selected liver components was studied on 4 groups of 12 periparturient dairy goats: control, CTR; choline supplemented, RPC; vitamin E, VITE; choline and vitamin E, RPCE. Plasma folate did not differ between groups, except at parturition when RPC and RPCE goats had higher folate levels than CTR and VITE animals. Neither RPC nor vitamin E affected vitamin B12 plasma concentrations, while a time effect was observed after the third week of lactation, when B12 levels in each group started to increase. Alpha-tocopherol supplementation was associated with increased plasma a-tocopherol in the VITE and RPCE compared to the CRT and RPC groups, while RPC supplementation did not affect a-tocopherol levels in both RPC and RPCE groups compared to CTR and VITE ones. In control and RPC goats liver total lipid did not differ, while DNA contents and their ratio, were respectively higher and lower in RPC supplemented animals. Overall these results suggest that greater choline availability seems to be essential for optimising metabolic health and methyl group status, in dairy ruminants.

  8. Evaluation of high-voltage, high-power, solid-state remote power controllers for amps

    Science.gov (United States)

    Callis, Charles P.

    1987-01-01

    The Electrical Power Branch at Marshall Space Flight Center has a Power System Development Facility where various power circuit breadboards are tested and evaluated. This project relates to the evaluation of a particular remote power controller (RPC) energizing high power loads. The Facility equipment permits the thorough testing and evaluation of high-voltage, high-power solid-state remote power controllers. The purpose is to evaluate a Type E, 30 Ampere, 200 V dc remote power controller. Three phases of the RPC evaluation are presented. The RPC is evaluated within a low-voltage, low-power circuit to check its operational capability. The RPC is then evaluated while performing switch/circuit breaker functions within a 200 V dc, 30 Ampere power circuit. The final effort of the project relates to the recommended procedures for installing these RPC's into the existing Autonomously Managed Power System (AMPS) breadboard/test facility at MSFC.

  9. Impact of rapeseed press-cake on Maillard reaction in a cookie model system.

    Science.gov (United States)

    Troise, Antonio Dario; Wilkin, Jonathan Desmond; Fiore, Alberto

    2018-03-15

    Rapeseed press-cake (RPC) is a byproduct of rapeseed oil production, rich in proteins and fiber. The aim of this study was to investigate the impact of cold pressed RPC, RPC fiber isolate and RPC alkaline extract on the formation of acrylamide and 5-hydroxymethylfufural (HMF) in cookies. Both compounds were influenced by the ingredients: the addition of RPC led to a significant dose-dependent increase of HMF in the cookies and to an increase of acrylamide up to 66.9%. On the contrary, acrylamide concentration was reduced down to 39.6% in presence of the alkaline extract and down to 4.4% in the presence of the fiber extract. The Michael addition of free amino acids to acrylamide was further investigated by high-resolution mass spectrometry (HRMS) revealing that cysteine was the preferred nucleophile for acrylamide elimination. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Measurement Uncertainty Estimation of a Robust Photometer Circuit

    Directory of Open Access Journals (Sweden)

    Jesús de Vicente

    2009-04-01

    Full Text Available In this paper the uncertainty of a robust photometer circuit (RPC was estimated. Here, the RPC was considered as a measurement system, having input quantities that were inexactly known, and output quantities that consequently were also inexactly known. Input quantities represent information obtained from calibration certificates, specifications of manufacturers, and tabulated data. Output quantities describe the transfer function of the electrical part of the photodiode. Input quantities were the electronic components of the RPC, the parameters of the model of the photodiode and its sensitivity at 670 nm. The output quantities were the coefficients of both numerator and denominator of the closed-loop transfer function of the RPC. As an example, the gain and phase shift of the RPC versus frequency was evaluated from the transfer function, with their uncertainties and correlation coefficient. Results confirm the robustness of photodiode design.

  11. Silica Fume and Fly Ash Admixed Can Help to Improve the PRC Durability Combine Microscopic Analysis

    Directory of Open Access Journals (Sweden)

    Xiao Li-guang

    2016-01-01

    Full Text Available Silica fume/Fly ash RPC can greatly improve durability. When Silica fume to replace the same amount of 8% of the proportion of cement, re-mixed 15min of mechanically activated Fly ash content of 10%, by chloride ion flux detector measuring, complex doped than the reference RPC impermeability improved significantly; In addition, by using static nitrogen adsorption method showed, RPC internal pore structure determination, the hole integral volume was lower than the reference admixed RPC integral pore volume significantly; And combined SEM microscopic experimental methods, mixed of RPC internal structure and the formation mechanism analysis showed that, SF/FA complex fully embodies the synergy doped composites “Synergistic” principle.

  12. Resistive Plate Chambers commissioning and performance results for 2011-2013.

    CERN Document Server

    CMS Collaboration

    2014-01-01

    Resistive Plate Chambers (RPC) performance results for the period between 2011-2013 are presented. These results include history plots for the RPC relevant variables such as: Cluster Size, Efficiency, percentage of inactive detector during operation, Rates, and Currents. RPC variables are studied as function of relevant parameters such as the averaged instantaneous luminosity of the LHC, time, and CMS cavern pressure. Results obtained with the monitoring tools used by CMS such as the Web Based Monitoring tool (WBM) are also shown. RPC Background rates measured during 2010, 2011, and 2012 are presented and compared. Preparations for the 2015 Run include the installation of a new couple of disks of RPCs in the endcap regions, results obtained during quality control campaigns for the new RPCs are also presented, these results include High voltage scans that probe the quality and standards of the RPC construction procedures, as well as tests on chamber gas leaks and current behavior for the new chambers. Basic p...

  13. Isolation and characterization of a native strain of Aspergillus niger ZRS14 with capability of high resistance to zinc and its supernatant application towards extracellular synthesis of zinc oxide nanoparticles

    Directory of Open Access Journals (Sweden)

    Morahem Ashengroph

    2013-01-01

    Full Text Available Introduction: Zinc oxide nanoparticles have quite a few applications in the fields of biology, optics, mechanics, magnetism, energy, hygiene and medicine. Due to serious problems associated with physiochemical synthesis of ZnO nanoparticles, including environmental pollution, complicated and costly processes, there is a growing need to develop a simple biological procedure for synthesis of nanoparticles to achieve the monodisperse-sized particles with a higher purity, low energy consumption and a cleaner environment. We conducted this investigation to screen and isolate native fungi strains capable of high zinc metal tolerance ability and a potential for extracellular synthesis of ZnO nanoparticles using fungal secretions as biological catalysts.Materials and methods: 15 different strains of fungi were isolated from soil samples collected from lead and zinc mines of Angoran-Zanjan using conventional enrichment process and characterized initially based on macroscopic and microscopic characteristics and colony morphology. The intrinsic tolerance of the isolated strains to zinc toxic metal was measured in the synthetic and complex media using the agar dilution method. The supernatants of isolated fungi were incubated with zinc acetate solution in a shaker incubator for 72h; then, the strain that was able to synthesis ZnO nanoparticle was identified. The ZnO nanoparticles formation was investigated by using spectroscopic techniques and microscopic observations.Results: Among the 15 isolated strains, the strain ZRS14 had highest zinc metal tolerance ability and was selected and identified as Aspergillus niger strain ZRS14 (GenBank accession number KF414527 based on morphological and molecular phylogenetic analysis. For synthesis of ZnO nanoparticles by isolated A. niger ZRS14, fungal cell-free filtrate of the strain was collected and incubated in the presence of zinc acetate solution at a final concentration of 250 mg/l zinc metal ion at 28º C for 72 h on a rotary shaker (150 rpm under dark conditions. Results obtained by visual observations, spectral data achieved from UV–vis, XRD spectrum and SEM micrographs revealed the extracellular formation of ZnO nanoparticles with narrow size distribution and average particle size of 32 nm with the collected cell-free filtrate of A. niger isolate ZRS14. Discussion and conclusion: Owing to the extracellular synthesis of ZnO nanoparticles, the obtained results in the current study suggest that the A. niger strain ZRS14 has a considerable potentiality that can be efficiently used as an eco-friendly biocatalyst for the preparative synthesis of ZnO nanoparticles. The present investigation is the first report on the biological synthesis of ZnO nanoparticles using newly isolated strain of Aspergillus niger ZRS14.

  14. Highly resistant Salmonella Newport-MDRAmpC transmitted through the domestic US food supply: a FoodNet case-control study of sporadic Salmonella Newport infections, 2002-2003.

    Science.gov (United States)

    Varma, Jay K; Marcus, Ruthanne; Stenzel, Sara A; Hanna, Samir S; Gettner, Sharmeen; Anderson, Bridget J; Hayes, Tameka; Shiferaw, Beletshachew; Crume, Tessa L; Joyce, Kevin; Fullerton, Kathleen E; Voetsch, Andrew C; Angulo, Frederick J

    2006-07-15

    A new multidrug-resistant (MDR) strain of Salmonella serotype Newport, Newport-MDRAmpC, has recently emerged. We sought to identify the medical, behavioral, and dietary risk factors for laboratory-confirmed Salmonella Newport infection, including that with Newport-MDRAmpC. A 12-month population-based case-control study was conducted during 2002-2003 in 8 sites of the Foodborne Diseases Active Surveillance Network (FoodNet), with 215 case patients with Salmonella Newport infection and 1154 healthy community control subjects. Case patients with Newport-MDRAmpC infection were more likely than control subjects to have taken an antimicrobial agent to which Newport-MDRAmpC is resistant during the 28 days before the onset of diarrheal illness (odds ratio [OR], 5.0 [95% confidence interval {CI}, 1.6-16]). Case patients with Newport-MDRAmpC infection were also more likely to have eaten uncooked ground beef (OR, 7.8 [95% CI, 1.4-44]) or runny scrambled eggs or omelets prepared in the home (OR, 4.9 [95% CI, 1.3-19]) during the 5 days before the onset of illness. International travel was not a risk factor for Newport-MDRAmpC infection but was a strong risk factor for pansusceptible Salmonella Newport infection (OR, 7.1 [95% CI, 2.0-24]). Case patients with pansusceptible infection were also more likely to have a frog or lizard in their household (OR, 2.9 [95% CI, 1.1-7.7]). Newport-MDRAmpC infection is acquired through the US food supply, most likely from bovine and, perhaps, poultry sources, particularly among persons already taking antimicrobial agents.

  15. Synthesis and electrical properties of BaBiO 3 and high resistivity BaTiO 3 –BaBiO 3 ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Nitish [Oregon State Univ., Corvallis, OR (United States); Univ. of New South Wales, Sydney, NSW (Australia); Golledge, Stephen L. [Univ. of Oregon, Eugene, OR (United States); Cann, David P. [Oregon State Univ., Corvallis, OR (United States)

    2016-12-01

    Ceramics of the composition BaBiO3 (BB) were sintered in oxygen to obtain a single phase with monoclinic II2/mm symmetry as suggested by high-resolution X-ray diffraction. X-ray photoelectron spectroscopy confirmed the presence of bismuth in two valence states - 3+ and 5+. Optical spectroscopy showed presence of a direct bandgap at ~ 2.2eV and a possible indirect bandgap at ~ 0.9eV. This combined with determination of the activation energy for conduction of 0.25eV, as obtained from ac impedance spectroscopy, suggested that a polaron-mediated conduction mechanism was prevalent in BB. The BB ceramics were crushed, mixed with BaTiO3 (BT), and sintered to obtain BT–BB solid solutions. All the ceramics had tetragonal symmetry and exhibited a normal ferroelectric-like dielectric response. Using ac impedance and optical spectroscopy, it was shown that resistivity values of BT–BB were orders of magnitude higher than BT or BB alone, indicating a change in the fundamental defect equilibrium conditions. A shift in the site occupancy of Bi to the A-site is proposed to be the mechanism for the increased electrical resistivity.

  16. Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?

    Science.gov (United States)

    Branquinho, Diogo; Almeida, Nuno; Gregório, Carlos; Cabral, José Eduardo Pina; Casela, Adriano; Donato, Maria Manuel; Tomé, Luís

    2017-02-15

    Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxacin-containing regimens could be an option for first-line treatment, but its efficacy should be evaluated as fluoroquinolone resistance is rapidly increasing. Our aim was to compare the efficacy of Clarithromycin and Levofloxacin-based sequential quadruple therapies as first-line treatment options and determine factors associated with treatment failure. A total of 200 Helicobacter pylori infected patients were retrospectively included (female 57.5%; average age: 53.2 ± 15.7) and received either 10-day sequential therapy (Proton-Pump Inhibitor + Amoxicillin 1 g bid for 5 days and Proton-Pump Inhibitor + Clarithromycin 500 mg + Metronidazole/Tinidazole 500 mg bid/tid in the following 5 days; group A) or a 10-day modified sequential therapy with Levofloxacin 500 mg id instead of Clarithromycin (group B). Eradication was confirmed with urea breath test. Variables that could influence success rate were analyzed. There were no differences between groups in terms of gender, age, smoking habits and indications for treatment. The eradication rate obtained with Clarithromycin-based sequential treatment was significantly higher than with Levofloxacin-based therapy (90%, CI95%: 84-96% vs. 79%, CI95%: 71-87%, p = 0.001). Using full-dose proton-pump inhibitor and high-dose Metronidazole in group A, and full-dose proton-pump inhibitor and prescription from a Gastroenterologist in group B were associated with eradication success. Ten-day Levofloxacin-based sequential treatment achieved inadequate efficacy rate (<80%) and should not be adopted as first-line therapy. Standard sequential therapy showed significantly better results in this naïve population. Using full-dose proton-pump inhibitor and higher doses of Metronidazole is essential to achieve such results.

  17. Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Szu-Hsien [Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China); Tsao, Ching-Ting [Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China); Epithelial Biology Laboratory/Transgenic Mice Core-Laboratory, Department of Anatomy, Chang Gung University, Taoyuan 33302, Taiwan (China); Chang, Chih-Hao [Department of Orthopedics, National Taiwan University Hospital, Taiwan (China); National Taiwan University College of Medicine, No. 1, Jen-Ai Road, Taipei City 10018, Taiwan (China); Lai, Yi-Ting [Department of Chemical Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China); Wu, Ming-Fung [Animal Medicine Center, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Taipei City 10018, Taiwan (China); Chuang, Ching-Nan [Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China); Chou, Hung-Chia [Department of Chemical Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China); Wang, Chih-Kuang, E-mail: ckwang@kmu.edu.tw [Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan (China); Hsieh, Kuo-Haung, E-mail: khhsieh@ntu.edu.tw [Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei City 10617, Taiwan (China)

    2013-07-01

    Wound dressings of chitosan are biocompatible, biodegradable, antibacterial and hemostatic biomaterials. However, applications for chitosan are limited due to its poor mechanical properties. Here, we conducted an in vivo mouse angiogenesis study on reinforced poly(ethylene glycol) (PEG)-chitosan (RPC) hydrogels. RPC hydrogels were formed by cross-linking chitosan with PEGs of different molecular weights at various PEG to chitosan ratios in our previous paper. These dressings can keep the wound moist, had good gas exchange capacity, and was capable of absorbing or removing the wound exudate. We examined the ability of these RPC hydrogels and neat chitosan to heal small cuts and full-thickness skin defects on the backs of male Balb/c mice. Histological examination revealed that chitosan suppressed the infiltration of inflammatory cells and accelerated fibroblast proliferation, while PEG enhanced epithelial migration. The RPC hydrogels promoted wound healing in the small cuts and full layer wounds. The optimal RPC hydrogel had a swelling ratio of 100% and a water vapor transmission rate (WVTR) of about 2000 g/m{sup 2}/day. In addition, they possess good mechanical property and appropriate degradation rates. Thus, the optimal RPC hydrogel formulation functioned effectively as a wound dressing and promoted wound healing. Highlights: ► Mouse angiogenesis study on reinforced poly(ethylene glycol)-chitosan (RPC) ► Water vapor transmission rate of about 2000 g/m{sup 2}/day is characteristic of RPC. ► RPC suppressed inflammatory cells and accelerated fibroblast proliferation. ► RPC composed of 1000-RP10C90 can be used as a biomaterial for wound dressing.

  18. Effect of Modified Red Pottery Clay on the Moisture Absorption Behavior and Weatherability of Polyethylene-Based Wood-Plastic Composites.

    Science.gov (United States)

    Li, Qingde; Gao, Xun; Cheng, Wanli; Han, Guangping

    2017-01-26

    Red pottery clay (RPC) was modified using a silane coupling agent, and the modified RPC (mRPC) was then used to enhance the performance of high-density polyethylene-based wood-plastic composites. The effect of the mRPC content on the performances of the composites was investigated through Fourier transform infrared spectrometry, differential mechanical analysis (DMA) and ultraviolet (UV)-accelerated aging tests. After adding the mRPC, a moisture adsorption hysteresis was observed. The DMA results indicated that the mRPC effectively enhanced the rigidity and elasticity of the composites. The mRPC affected the thermal gravimetric, leading to a reduction of the thermal degradation rate and a right-shift of the thermal degradation peak; the initial thermal degradation temperature was increased. After 3000 h of UV-accelerated aging, the flexural strength and impact strength both declined. For aging time between 0 and 1000 h, the increase in amplitude of ΔL* (luminescence) and ΔE* (color) reached a maximum; the surface fading did not became obvious. ΔL* and ΔE* increased more significantly between 1000 and 2000 h. These characterization results indicate that the chromophores of the mRPC became briefly active. However, when the aging times were higher than 2000 h, the photo-degradation reaction was effectively prevented by adding the mRPC. The best overall enhancement was observed for an mRPC mass percentage of 5%, with a storage modulus of 3264 MPa and an increase in loss modulus by 16.8%, the best anti-aging performance and the lowest degree of color fading.

  19. Anti-allergic activity of R-phycocyanin from Porphyra haitanensis in antigen-sensitized mice and mast cells.

    Science.gov (United States)

    Liu, Qingmei; Wang, Youzhao; Cao, Minjie; Pan, Tzuming; Yang, Yang; Mao, Haiyan; Sun, Lechang; Liu, Guangming

    2015-04-01

    The prevalence of food allergy has increased in Asian countries. Marine algae have been proposed as the potential resource for anti-allergic therapeutics. The present study was aimed at isolating R-phycocyanin (RPC) from Porphyra haitanensis and determining the anti-allergy potential of RPC in antigen-sensitized mice and mast cells. In animal experiments, RPC could effectively reduce tropomyosin (TM)-specific immunoglobulin E (IgE) and histamine levels, alleviate allergy symptoms and jejunum tissue inflammation in mice, and inhibit the expression and release of cytokines (interleukin-4 (IL-4) and IL-13) in peritoneal lavage fluid. In spleen lymphocyte experiments, high purity of RPC skewed the immunological function of CD4(+) T cells towards Th1 activity. A higher expression of interferon (IFN)-γ was induced by a synergistic effect of TM and RPC. Through the Jun N-terminal kinase and Janus kinase 2 signaling pathways, IFN-γ synthesis was induced by RPC in combination with TM. Anti-allergic effect of RPC was evaluated in IgE-mediated rat mast RBL-2H3 cells. The results demonstrated that RPC inhibited allergy markers, including the release of β-hexosaminidase, histamine and ROS in antigen-sensitized RBL-2H3 cells. RPC also suppressed the production of pro-inflammatory factors (IL-4 and tumor necrosis factor-α). In conclusion, RPC decreased allergic sensitization against TM by blocking Th2 cell polarization as well as suppressed the release of allergic-mediators in antigen-stimulated mast cells. It may be used as a functional food component or active pharmaceutical ingredient for allergic patients. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Bone marrow mesenchymal stem cells stimulate proliferation and neuronal differentiation of retinal progenitor cells.

    Directory of Open Access Journals (Sweden)

    Jing Xia

    Full Text Available During retina development, retinal progenitor cell (RPC proliferation and differentiation are regulated by complex inter- and intracellular interactions. Bone marrow mesenchymal stem cells (BMSCs are reported to express a variety of cytokines and neurotrophic factors, which have powerful trophic and protective functions for neural tissue-derived cells. Here, we show that the expanded RPC cultures treated with BMSC-derived conditioned medium (CM which was substantially enriched for bFGF and CNTF, expressed clearly increased levels of nuclear receptor TLX, an essential regulator of neural stem cell (NSC self-renewal, as well as betacellulin (BTC, an EGF-like protein described as supporting NSC expansion. The BMSC CM- or bFGF-treated RPCs also displayed an obviously enhanced proliferation capability, while BMSC CM-derived bFGF knocked down by anti-bFGF, the effect of BMSC CM on enhancing RPC proliferation was partly reversed. Under differentiation conditions, treatment with BMSC CM or CNTF markedly favoured RPC differentiation towards retinal neurons, including Brn3a-positive retinal ganglion cells (RGCs and rhodopsin-positive photoreceptors, and clearly diminished retinal glial cell differentiation. These findings demonstrate that BMSCs supported RPC proliferation and neuronal differentiation which may be partly mediated by BMSC CM-derived bFGF and CNTF, reveal potential limitations of RPC culture systems, and suggest a means for optimizing RPC cell fate determination in vitro.

  1. Consumption of a single serving of red raspberries per day reduces metabolic syndrome parameters in high-fat fed mice.

    Science.gov (United States)

    Luo, T; Miranda-Garcia, O; Sasaki, G; Shay, N F

    2017-11-15

    Using an animal model for diet-induced metabolic disease, we have shown previously that the addition of raspberry juice concentrate (RJC) and raspberry puree concentrate (RPC) at a level of 10% of kcal, equivalent to four servings per day, to an obesogenic high-fat, western-style diet (HF) significantly reduced body weight gain, serum resistin levels, and altered the expression of hepatic genes related to lipid metabolism and oxidative stress. This study was designed to examine the effect of a lower level of RJC or RPC consumption, at a level representing a single serving of food per day (2.5% of kcal). For ten weeks, four groups of C57BL/6J mice (n = 8 ea.) were fed: low fat (LF), HF, HF + RJC, or HF + RPC diets. Intake of RJC and RPC decreased final body weight. Hepatic lipid accumulation was significantly decreased in HF + RPC- and HF + RJC-fed mice, compared to HF-fed mice. Further, the relative expression of hepatic genes including Heme oxygenase 1 (Hmox1) and Hormone sensitive lipase (Lipe), were altered by RPC or RJC consumption. In this mouse model of diet-induced metabolic disease, consumption of the equivalent of a single daily serving of either RPC or RJC improved metabolism in mice fed HF diet. We hypothesize that the phytochemicals contained in raspberries, and/or their subsequent metabolites, may be acting to influence gene expression and other regulatory pathways, to produce the metabolic improvements observed in this study.

  2. Improvement of the dynamic response of the ITER Reactive Power Compensation system

    Energy Technology Data Exchange (ETDEWEB)

    Finotti, Claudio, E-mail: claudio.finotti@igi.cnr.it [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Gaio, Elena [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Song, Inho; Tao, Jun; Benfatto, Ivone [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

    2015-10-15

    Highlights: • The slow response reasons of the classic ITER Reactive Power Compensation (RPC) control are explained. • The dynamic behaviors of the ac/dc converter and of the RPC are characterized. • New control concept to speed up the RPC response is developed. • Good performance of the new RPC control is verified even during fast transient conditions. - Abstract: The ITER ac/dc conversion system can absorb a total active and reactive power up to 500 MW and 950 Mvar, respectively. The Reactive Power Compensation (RPC) system is rated for a nominal power of 750 Mvar necessary to comply with the allowable reactive power limit value from the grid of 200 Mvar. This system is currently under construction and is based on Static Var Compensation technology with Thyristor Controlled Reactor (TCR) and Tuned Filters. The RPC has to minimize the demand of reactive power from the grid; its control is based on a feed-forward method, where the corrective input is the measurement of the reactive power consumption of the ac/dc converters, derived from the 50 Hz component of the Fast Fourier Transform (FFT) of the three-phase voltages and currents. The delay introduced by the FFT calculation and the slow response of the TCR could make the response speed of the RPC not sufficient to face fast variations of the reactive power demand and therefore in this paper a new controller of the RPC able to overcome this shortcoming is proposed and evaluated. It is based on the calculation of the predicted consumption of the reactive power by using the voltage reference signals coming from the Plasma Control System and the measurements of the dc current of the ac/dc converters and of the 66 kV busbar voltage, and on the speed up of the RPC control by introducing a lead–lag transfer function.

  3. Network Science Research Laboratory (NSRL) Telemetry Warehouse

    Science.gov (United States)

    2016-06-01

    Collection, Storage, and Retrieval 3 3.2 Comparative Analysis 4 3.3 Data Processing 4 4. Architecture 4 4.1 NTW Database 6 4.2 NTW Server 6 4.4...efforts between ARL and the US Naval Research Laboratory (NRL). The primary emulation tools used by ARL are the Extendable Mobile Ad -Hoc Network...procedure call (gRPC) system. The gRPC system uses the Google protocol buffers compiler to generate the code for the server . gRPC handles many of the basic

  4. Maduración ósea postnatal en ratas con retardo prenatal de crecimiento inducido experimentalmente

    OpenAIRE

    Fucini, María Cecilia; Cesani Rossi, María Florencia; Quintero, Fabián; Castro, Luis Eduardo; Villanueva, Miriam; Prio, María Verónica; Guimarey Luis Manuel; Oyhenart, Evelia Edith

    2009-01-01

    El retardo prenatal de crecimiento o RPC se caracteriza por una reducción de la tasa de crecimiento fetal que impide que los niños desarrollen su completo potencial de crecimiento. El ligamiento de los vasos uterinos en la rata, es un modelo experimental que produce RPC ponderal y óseo (craneano y postcraneano). En tal sentido, estudios previos realizados por nuestro equipo de investigación, dieron cuenta que el RPC, producto de una insuficiencia útero placentaria, provoca retardo de crecimie...

  5. Effective atomic numbers of some H-, C-, N-and O-based composite ...

    Indian Academy of Sciences (India)

    The differential incoherent scattering cross-sections of the composite materials of interest measured at these three angles in the same set-up and substituted in this expression would yield their effective atomic number at the three energies. Results obtained in this manner for bakelite, nylon, epoxy, teflon, perspex and some ...

  6. Reactive powder concrete reinforced with steel fibres exposed to high temperatures

    Science.gov (United States)

    Alrekabi, T. Kh; Cunha, V. M. C. F.; Barros, J. A. O.

    2017-09-01

    An experimental investigation was carried out to assess the mechanical properties of reactive powder concrete (RPC) reinforced with steel fibres (2% in vol.) when exposed to high temperatures. The compressive, flexural and tensile strength, modulus of elasticity and post-cracking behaviour were assessed after specimens’ exposure to different high temperatures ranging from 400 to 700°C. The mechanical properties of the RPC were assessed for specimens dried for 24 hours at 60 °C and 100 °C. Partially dried specimens (60 °C) exhibited explosive spalling at nearby 450 °C, while fully dried RPC specimens (100 °C) maintained their integrity after heating exposure. In general, the mechanical properties of RPC significantly decreased with the increase of the temperature exposure. The rate of decrease with temperature of the compressive, tensile and flexural strengths, as well the corresponding post-cracking residual stresses was higher for exposure temperatures above the 400 °C.

  7. Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

    OpenAIRE

    Hübsch, Chris

    2001-01-01

    Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

  8. Gclust Server: 95544 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 95544 Rpa3_RPC_0084 Cluster Sequences - 671 TonB-dependent receptor, plug 1 1.00e+0...luster Sequences Link to related sequences - Sequence length 671 Representative annotation TonB-dependent receptor, plug

  9. Developing Cyberspace Data Understanding: Using CRISP-DM for Host-based IDS Feature Mining

    Science.gov (United States)

    2010-03-01

    11 HTTP HyperText Transfer Protocol . . . . . . . . . . . . . . . . 22 LDAP Lightweight Directory Access Protocol...specialized services such as NetBIOS, HyperText Transfer Protocol (HTTP), RPC, Lightweight Directory Access Protocol ( LDAP ), Structured Query Language (SQL

  10. The role of robotic partial cystectomy in a patient with metastatic primary adenocarcinoma of the bladder

    Directory of Open Access Journals (Sweden)

    Katherine James

    2015-03-01

    Full Text Available Treatment of urachal adenocarcinoma (UA of the urinary bladder has typically been with radical cystectomy (RC but more conservative approaches are gaining popularity. Here we present the case of a female patient with metastatic primary bladder UA who was treated with robotic partial cystectomy (RPC and adjuvant chemotherapy; she is alive with no evidence of disease recurrence or metastatic disease at 5 years. This case provides some of the longest follow-up after RPC to date thereby demonstrating that RPC is a safe and oncologically viable treatment for selected patients even several years after definitive treatment. Patients undergoing RPC benefit from the reduced morbidity associated with this less radical treatment whilst enjoying similarly successful oncological outcomes to RC.   

  11. Micro Environmental Concrete

    Science.gov (United States)

    Lanez, M.; Oudjit, M. N.; Zenati, A.; Arroudj, K.; Bali, A.

    Reactive powder concretes (RPC) are characterized by a particle diameter not exceeding 600 μm and having very high compressive and tensile strengths. This paper describes a new generation of micro concrete, which has an initial as well as a final high physicomechanical performance. To achieve this, 15% by weight of the Portland cement have been substituted by materials rich in Silica (Slag and Dune Sand). The results obtained from the tests carried out on the RPC show that compressive and tensile strengths increase when incorporating the addition, thus improving the compactness of mixtures through filler and pozzolanic effects. With a reduction in the aggregate phase in the RPC and the abundance of the dune sand (southern of Algeria) and slag (industrial by-product of the blast furnace), the use of the RPC will allow Algeria to fulfil economical as well as ecological requirements.

  12. ROSETTA-ORBITER 67P RPCMIP 3 PRL3 V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This archive contains data from the RPC-MIP instrument onboard ROSETTA Orbiter, acquired in the vicinity of 67P/CG during the prelanding part 3 mission phase. It...

  13. ROSETTA-ORBITER 67P RPCMIP 3 PRL1 V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This archive contains data from the RPC-MIP instrument onboard ROSETTA Orbiter, acquired during the prelanding part 1 phase at the vicinity of the comet 67P/CG. It...

  14. Sequence Classification: 893175 [

    Lifescience Database Archive (English)

    Full Text Available rase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; Rpc34p || http://www.ncbi.nlm.nih.gov/protein/6324330 ...

  15. Effects of rumen-protected Capsicum oleoresin on immune responses in dairy cows intravenously challenged with lipopolysaccharide.

    Science.gov (United States)

    Oh, J; Harper, M; Giallongo, F; Bravo, D M; Wall, E H; Hristov, A N

    2017-03-01

    The objective of this experiment was to investigate the effects of rumen-protected Capsicum oleoresin (RPC) on productivity and immune responses including feed intake, milk yield and composition, white and red blood cells, lipid peroxidation, and blood concentration of cortisol, haptoglobin, glucose, and insulin in lactating dairy cows experimentally challenged with lipopolysaccharide (LPS). The experiment was a replicated 3 × 3 Latin square design with 9 multiparous Holstein cows in three 28-d periods. Treatments were 0 (control), 100, and 200 mg of RPC/cow per day, mixed with small portions of the total mixed ration and top-dressed. Bacterial LPS was intravenously administered at 1.0 μg/kg of body weight in the last week of each experimental period, and blood samples were collected at 0, 2, 4, 8, and 24 h after administration. Dry matter intake, milk yield, and white blood cells including neutrophils, lymphocytes, monocytes, and eosinophils were decreased, and rectal temperature, hemoglobin, and serum concentrations of cortisol and haptoglobin were increased by LPS. Red blood cells, platelets, and plasma concentration of thiobarbituric acid reactive substances were not affected by LPS. Dry matter intake, milk yield, and milk composition in the 5 d post-LPS challenge were not affected by RPC. Rectal temperature, white blood cells, red blood cells, hemoglobin, and platelets were also not affected by RPC. Compared with the control, RPC tended to decrease cortisol at 2 h following LPS challenge and decreased haptoglobin concentration in serum across sampling points. Concentration of thiobarbituric acid reactive substances in plasma was decreased by RPC at 24 h post-LPS challenge. Glucose and insulin were not affected by RPC, but serum insulin concentration at 8 h was lowered by RPC compared to the control. Collectively, RPC had no or subtle effects on feed intake, milk yield and composition, rectal temperature, white and red blood cells, and serum glucose and

  16. Streamer free operation of a 2 mm gap resistive plate chamber with $C_{2}F_{5}H$

    CERN Document Server

    Cerron-Zeballos, E; Hatzifotiadou, D; Lamas-Valverde, J; Williams, M C S; Zichichi, A

    1999-01-01

    It is necessary to operate the resistive plate chamber (RPC) in avalanche mode to obtain high efficiency at elevated particle fluxes. We examine this mode of operation with a 2 mm gap RPC using gas mixtures containing C/sub 2/F/sub 4/H/sub 2/ and C/sub 2/F/sub 5/H. In order to explain the data we propose that the avalanche growth is strongly limited by space charge effects. (10 refs).

  17. Light stop squarks and b-tagging

    CERN Document Server

    Ferretti, Gabriele; Petersson, Christoffer; Torre, Riccardo

    2015-01-01

    A significant part of the parameter space for light stop squarks still remains unconstrained by collider searches. For both R-Parity Conserving (RPC) and R-Parity Violating (RPV) scenarios there are regions in which the stop mass is around or below the top quark mass that are particularly challenging experimentally. Here we review the status of light stop searches, both in RPC and RPV scenarios. We also propose strategies, generally based on exploiting b-tagging, to cover the unconstrained regions.

  18. Reverse phase contrast: an experimental demonstration.

    Science.gov (United States)

    Mogensen, Paul C; Glückstad, Jesper

    2002-04-10

    We present experimental results showing that the reverse phase contrast (RPC) technique is a viable method for the generation of a binary phase distribution from a spatially varying amplitude pattern using Fourier plane filtering techniques. Experimental results are shown for the generation of a binary 0-pi phase only distribution using either an amplitude mask or a spatial light modulator to provide the input and the results are shown to be in agreement with theoretical predictions for the RPC technique.

  19. IJIERT-STUDY ON THE EFFECT OF REACTIVE POWDER CONCRETE ON THE COMPRESSIVE STRENGTH AND WORKABILITY

    OpenAIRE

    ADITYA PATIL; VISHAL PATIL; AKASH PATIL

    2017-01-01

    The low tensile strength of concrete has many undesirable consequences for its performance as an efficient building material. This includes the need to support rebars as well as the requirement for thick-walled components that are beautiful and consume large quantities of aggregates. The total is an increasingly scarce resource in many urban areas. Reactive powder concrete(RPC) is a new technology that overcomes these limitations. Avoid aggregation in RPC to overcome the associated issues. RP...

  20. Review of Electrocution Deaths in Iraq: Part 1 - Electrocution of Staff Sergeant Ryan D. Maseth, U.S. Army

    Science.gov (United States)

    2009-07-24

    Contract and Task Order Administration..................................................... 31 Issue B5: Transfer of Operations and Maintenance at RPC to...related life, health, and safety issues. Issue B5: Transfer of Operations and Maintenance at RPC to LOGCAP III During 2006, the KBR Middle...Sergeant Ryan D. Maseth, U.S. Army July24, 2009 Report No. IE-2009-006 The recommendation from the Gulf Region Division to defer the transfer of operations and

  1. Identifying the Source of a Humoral Factor of Remote (PreConditioning Cardioprotection.

    Directory of Open Access Journals (Sweden)

    Svetlana Mastitskaya

    Full Text Available Signalling pathways underlying the phenomenon of remote ischaemic preconditioning (RPc cardioprotection are not completely understood. The existing evidence agrees that intact sensory innervation of the remote tissue/organ is required for the release into the systemic circulation of preconditioning factor(s capable of protecting a transplanted or isolated heart. However, the source and molecular identities of these factors remain unknown. Since the efficacy of RPc cardioprotection is critically dependent upon vagal activity and muscarinic mechanisms, we hypothesized that the humoral RPc factor is produced by the internal organ(s, which receive rich parasympathetic innervation. In a rat model of myocardial ischaemia/reperfusion injury we determined the efficacy of limb RPc in establishing cardioprotection after denervation of various visceral organs by sectioning celiac, hepatic, anterior and posterior gastric branches of the vagus nerve. Electrical stimulation was applied to individually sectioned branches to determine whether enhanced vagal input to a particular target area is sufficient to establish cardioprotection. It was found that RPc cardioprotection is abolished in conditions of either total subdiaphragmatic vagotomy, gastric vagotomy or sectioning of the posterior gastric branch. The efficacy of RPc cardioprotection was preserved when hepatic, celiac or anterior gastric vagal branches were cut. In the absence of remote ischaemia/reperfusion, electrical stimulation of the posterior gastric branch reduced infarct size, mimicking the effect of RPc. These data suggest that the circulating factor (or factors of RPc are produced and released into the systemic circulation by the visceral organ(s innervated by the posterior gastric branch of the vagus nerve.

  2. Rapid Detection and Characterisation of Triterpene Saponins from the Root of Pulsatilla chinensis (Bunge) Regel by HPLC-ESI-QTOF-MS/MS.

    Science.gov (United States)

    Ling, Yun; Lin, Zhanqing; Zha, Wenjuan; Lian, Tou; You, Shanshan

    2016-05-01

    Triterpene saponins are the major bioactive components in the root of Pulsatilla chinensis (Bunge) Regel (RPC), and have been reported to possess antitumor and immunological adjuvant activities. However, the isolation, purification and elucidation procedures of triterpene saponins from RPC are difficult and time consuming due to high polarity and structural similarity. To develop an analytical strategy for discovering and elucidating triterpene saponins in RPC. Methanolic extract of RPC is analysed by high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight-mass spectrometry (HPLC-ESI-QTOF-MS/MS). The MS and MS/MS experiments are conducted using the negative-ionisation mode, in order to provide molecular-mass information and production spectra for the structural elucidation of compounds. Based on retention times, accurate mass and mass spectrometric fragmentation, 24 triterpene saponins are identified or tentatively elucidated from RPC, of which nine triterpene saponins were not reported previously. The HPLC-ESI-QTOF-MS/MS could be employed as a rapid, effective technique to screen and identify triterpene saponins in RPC without tedious and time-consuming isolation of pure constituents. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. RADIATION PROTECTION CABIN FOR CATHETER-DIRECTED LIVER INTERVENTIONS: OPERATOR DOSE ASSESSMENT.

    Science.gov (United States)

    Maleux, Geert; Bergans, Niki; Bosmans, Hilde; Bogaerts, Ria

    2016-09-01

    The number and complexity of interventional radiological procedures and in particular catheter-directed liver interventions have increased substantially. The current study investigates the reduction of personal doses when using a dedicated radiation protection cabin (RPC) for these procedures. Operator and assistant doses were assessed for 3 series of 20 chemoinfusion/chemoembolisation interventions, including an equal number of procedures with and without RPC. Whole body doses, finger doses and doses at the level of knees and eyes were evaluated with different types of TLD-100 Harshaw dosemeters. Dosemeters were also attached on the three walls of the RPC. The operator doses were significantly reduced by the RPC, but also without RPC, the doses appear to be limited as a result of thorough optimisation with existing radiation protection tools. The added value of the RPC should thus be determined by the outcome of balancing dose reduction and other aspects such as ergonomic benefits. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. Space station common module network topology and hardware development

    Science.gov (United States)

    Anderson, P.; Braunagel, L.; Chwirka, S.; Fishman, M.; Freeman, K.; Eason, D.; Landis, D.; Lech, L.; Martin, J.; Mccorkle, J.

    1990-01-01

    Conceptual space station common module power management and distribution (SSM/PMAD) network layouts and detailed network evaluations were developed. Individual pieces of hardware to be developed for the SSM/PMAD test bed were identified. A technology assessment was developed to identify pieces of equipment requiring development effort. Equipment lists were developed from the previously selected network schematics. Additionally, functional requirements for the network equipment as well as other requirements which affected the suitability of specific items for use on the Space Station Program were identified. Assembly requirements were derived based on the SSM/PMAD developed requirements and on the selected SSM/PMAD network concepts. Basic requirements and simplified design block diagrams are included. DC remote power controllers were successfully integrated into the DC Marshall Space Flight Center breadboard. Two DC remote power controller (RPC) boards experienced mechanical failure of UES 706 stud-mounted diodes during mechanical installation of the boards into the system. These broken diodes caused input to output shorting of the RPC's. The UES 706 diodes were replaced on these RPC's which eliminated the problem. The DC RPC's as existing in the present breadboard configuration do not provide ground fault protection because the RPC was designed to only switch the hot side current. If ground fault protection were to be implemented, it would be necessary to design the system so the RPC switched both the hot and the return sides of power.

  5. Noninvasive approach to mend the broken heart: Is "remote conditioning" a promising strategy for application in humans?

    Science.gov (United States)

    Ravingerová, Táňa; Farkašová, Veronika; Griecsová, Lucia; Muráriková, Martina; Carnická, Slavka; Lonek, L'ubomír; Ferko, Miroslav; Slezak, Jan; Zálešák, Marek; Adameova, Adriana; Khandelwal, Vinoth K M; Lazou, Antigone; Kolar, Frantisek

    2017-10-01

    Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing "remote" PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.

  6. Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015.

    Science.gov (United States)

    Wang, George Sam; Le Lait, Marie-Claire; Deakyne, Sara J; Bronstein, Alvin C; Bajaj, Lalit; Roosevelt, Genie

    2016-09-06

    As of 2015, almost half of US states allow medical marijuana, and 4 states allow recreational marijuana. To our knowledge, the effect of recreational marijuana on the pediatric population has not been evaluated. To compare the incidence of pediatric marijuana exposures evaluated at a children's hospital and regional poison center (RPC) in Colorado before and after recreational marijuana legalization and to compare population rate trends of RPC cases for marijuana exposures with the rest of the United States. Retrospective cohort study of hospital admissions and RPC cases between January 1, 2009, and December 31, 2015, at Children's Hospital Colorado, Aurora, a tertiary care children's hospital. Participants included patients 0 to 9 years of age evaluated at the hospital's emergency department, urgent care centers, or inpatient unit and RPC cases from Colorado for single-substance marijuana exposures. Marijuana. Marijuana exposure visits and RPC cases, marijuana source and type, clinical effects, scenarios, disposition, and length of stay. Eighty-one patients were evaluated at the children's hospital, and Colorado's RPC received 163 marijuana exposure cases between January 1, 2009, and December 31, 2015, for children younger than 10 years of age. The median age of children's hospital visits was 2.4 years (IQR, 1.4-3.4); 25 were girls (40%) . The median age of RPC marijuana exposures was 2 years (IQR, 1.3-4.0), and 85 patients were girls (52%). The mean rate of marijuana-related visits to the children's hospital increased from 1.2 per 100 000 population 2 years prior to legalization to 2.3 per 100,000 population 2 years after legalization (P = .02). Known marijuana products involved in the exposure included 30 infused edibles (48%). Median length of stay was 11 hours (interquartile range [IQR], 6-19) and 26 hours (IQR, 19-38) for admitted patients. Annual RPC pediatric marijuana cases increased more than 5-fold from 2009 (9) to 2015 (47). Colorado had an

  7. Long-term endoscopic management for primary recurrent pyogenic cholangitis

    Directory of Open Access Journals (Sweden)

    James L Buxbaum

    2014-01-01

    Full Text Available Background: Primary recurrent pyogenic cholangitis (RPC is characterized by relentless suppurative cholangitis in those with a suspected parasitic injury of the biliary tree. Prior work has demonstrated that the infections recur following "definitive" biliary surgery and long-term percutaneous biliary catheters are poorly tolerated. The aim of this study was to assess whether scheduled surveillance endoscopic retrograde cholangiopancreatography (ERCP prevents cholangitis in those with RPC. Materials and Methods: Following initial biliary decompression and stone clearance, patients with RPC were offered serial ERCP every 3-6 months to remove accumulating stony debris and to dilate incipient strictures. Review of a large series managed using this approach at the University of California, San Francisco Medical Center was performed. The principle outcome was the development of acute cholangitis requiring hospitalization and whether the episode occurred, while the RPC patient was in compliance with endoscopic surveillance recommendations. Results: Over a period of 10 years, 66 patients with primary RPC were managed for RPC at the University of California, San Francisco. The patients were comprised primarily of first-generation immigrants from Asia though one-quarter had migrated from Latin America and Russia. Episodes of cholangitis were significantly less likely to occur in those undergoing surveillance biliary endoscopy than in those who were not (odds ratio 5.3; P = 0.005 . The mean follow-up was 36.1 months. Conclusions: Serial endoscopic treatment of RPC may be used to systematically clear biliary debris and decreases the risk of cholangitis requiring hospitalization. It represents a reasonable initial management strategy for these patients. Surgery and percutaneous management may also be required, but are best performed as part of a multidisciplinary approach.

  8. Comparison of cyclic fatigue life of nickel-titanium files: an examination using high-speed camera

    Directory of Open Access Journals (Sweden)

    Taha Özyürek

    2017-08-01

    Full Text Available Objectives To determine the actual revolutions per minute (rpm values and compare the cyclic fatigue life of Reciproc (RPC, VDW GmbH, WaveOne (WO, Dentsply Maillefer, and TF Adaptive (TFA, Axis/SybronEndo nickel-titanium (NiTi file systems using high-speed camera. Materials and Methods Twenty RPC R25 (25/0.08, 20 WO Primary (25/0.08, and 20 TFA ML 1 (25/0.08 files were employed in the present study. The cyclic fatigue tests were performed using a dynamic cyclic fatigue testing device, which has an artificial stainless steel canal with a 60° angle of curvature and a 5-mm radius of curvature. The files were divided into 3 groups (group 1, RPC R25 [RPC]; group 2, WO Primary [WO]; group 3, TF Adaptive ML 1 [TFA]. All the instruments were rotated until fracture during the cyclic fatigue test and slow-motion videos were captured using high-speed camera. The number of cycles to failure (NCF was calculated. The data were analyzed statistically using one-way analysis of variance (ANOVA, p < 0.05. Results The slow-motion videos were indicated that rpm values of the RPC, WO, and TFA groups were 180, 210, and 425, respectively. RPC (3,464.45 ± 487.58 and WO (3,257.63 ± 556.39 groups had significantly longer cyclic fatigue life compared with TFA (1,634.46 ± 300.03 group (p < 0.05. There was no significant difference in the mean length of the fractured fragments. Conclusions Within the limitation of the present study, RPC and WO NiTi files showed significantly longer cyclic fatigue life than TFA NiTi file.

  9. How is rating of perceived capacity related to VO2max and what is VO2max at onset of training?

    Science.gov (United States)

    Gjestvang, Christina; Stensrud, Trine; Haakstad, Lene A H

    2017-01-01

    To evaluate how rating of perceived capacity (RPC) is related to maximal oxygen uptake (VO2max) and examine VO2max at onset of training in healthy adults. In total, 125 newly registered fitness centre members, equally men and women, answered the RPC scale and performed a treadmill test for measurement of VO2max. Eligible criteria were VO2max. The mean difference between the two methods were +4.92±1.96 and +6.35±1.96 mL/min/kg VO2 in men and women, respectively. The Pearson correlation coefficient was moderate, with r=0.426 (pVO2max were significant predictors of RPC (pVO2max at onset of fitness centre membership was in men aged 38.7±11.7 and women aged 34.7±9.9, 40.5±7.2 and 35.0±6.0 mL/min/kg, respectively. Estimated VO2max from the RPC scale was 45.7±9.8 and 41.4±10.1 mL/min/kg in men and women, respectively. The RPC seems less accurate at the individual level and may overestimate VO2max. Still, it may be considered useful in large-scale studies.

  10. Resistive Plate Chambers commissioning and performance results for 2015

    CERN Document Server

    CMS Collaboration

    2016-01-01

    The Resistive Plate Chamber (RPC) detector system at the Compact Muon Solenoid experiment at the LHC confers robustness and redundancy to the muon trigger. During the first long shutdown of the LHC (2013-2014) the CMS muon RPC system has been upgraded with 144 double-gap chambers on the forth forward stations. A total of 1056 double-gap chambers cover the pseudo-rapidity region up to 1.6. The main detector parameters are constantly and closely monitored to achieve operational stability and high quality data in the harsh conditions of the second run period of the LHC (13 TeV and 25 ns bunch spacing). Resistive Plate Chambers (RPC) performance results for 2015 with pp collisions at 13 TeV are presented. These results include the occupancy, efficiency of newly installed detectors after applying new working point, history plots for the RPC relevant variables such as: Cluster Size, Efficiency, percentage of inactive detector during operation and Rates and overall system noise. RPC variables are studied as funct...

  11. The Hysteretic Behavior of Partially Pre-Stressed Beam-Column Joint Sub-assemblages Made of Reactive Powder Concrete

    Directory of Open Access Journals (Sweden)

    Siti Aisyah Nurjannah

    2016-11-01

    Full Text Available Reactive powder concrete (RPC is an alternative to normal concrete (NC allowing for significantly higher strength of partially pre-stressed concrete structures. In the Indonesian national standard SNI 03-2847-2013 (2013 and the American standard ACI 318-14 (2014, the partial pre-stressed ratio (PPR is limited to a maximum of 25.0 percent to ensure that pre-stressed concrete structures remain ductile and capable to dissipate seismic energy sufficiently. The objective of this experimental study was to investigate the hysteretic performance of partially pre-stressed-RPC (PP-RPC for both interior and exterior beam-column joint sub-assemblages. Four specimens with different levels of PPR were tested with a combination of constant axial compression and cyclic lateral loads. The PPR used for the first and the second two specimens were 22.8% and 33.8%, respectively. The strength of the RPC was 101.60 MPa for all specimens. The results showed that increasing the PPR of PP-RPC improves its hysteretic performance. The best performing specimen, with a PPR of 33.8%, had a ductility that was 1.97 times that of the specimen with a PPR of 22.8%.

  12. Duplication and Loss of Function of Genes Encoding RNA Polymerase III Subunit C4 Causes Hybrid Incompatibility in Rice

    Directory of Open Access Journals (Sweden)

    Giao Ngoc Nguyen

    2017-08-01

    Full Text Available Reproductive barriers are commonly observed in both animals and plants, in which they maintain species integrity and contribute to speciation. This report shows that a combination of loss-of-function alleles at two duplicated loci, DUPLICATED GAMETOPHYTIC STERILITY 1 (DGS1 on chromosome 4 and DGS2 on chromosome 7, causes pollen sterility in hybrid progeny derived from an interspecific cross between cultivated rice, Oryza sativa, and an Asian annual wild rice, O. nivara. Male gametes carrying the DGS1 allele from O. nivara (DGS1-nivaras and the DGS2 allele from O. sativa (DGS2-T65s were sterile, but female gametes carrying the same genotype were fertile. We isolated the causal gene, which encodes a protein homologous to DNA-dependent RNA polymerase (RNAP III subunit C4 (RPC4. RPC4 facilitates the transcription of 5S rRNAs and tRNAs. The loss-of-function alleles at DGS1-nivaras and DGS2-T65s were caused by weak or nonexpression of RPC4 and an absence of RPC4, respectively. Phylogenetic analysis demonstrated that gene duplication of RPC4 at DGS1 and DGS2 was a recent event that occurred after divergence of the ancestral population of Oryza from other Poaceae or during diversification of AA-genome species.

  13. Properties of Reactive Powder Concrete and Its Application in Highway Bridge

    Directory of Open Access Journals (Sweden)

    Junwei Song

    2016-01-01

    Full Text Available A high-performance reactive powder concrete (RPC was prepared with river sand, and the maximum particle size is 1.25 mm, under the 80°C steam curing condition. It is tested completely in terms of strength, uniaxial compressive stress-strain relation, flexural load-deflection relation, and frost resisting durability, and the results indicate that the concrete is suitable to RPC200. The uniaxial compressive stress-strain curve shows a linear-elastic behaviour up to explosive failure, which is different from that of conventional concrete. High postpeak load carrying capacity shows high toughness and reinforcing effect of the steel fibers. The RPC has not only much higher limit strain than conventional concrete, but also excellent frost resisting durability at the fifth day of age exceeding F300. Furthermore, the RPC satisfactorily meets the requirement of practical application for Xialouzi Bridge built with the RPC totally according to the calculation with finite element analysis software MIDAS/Civil. And the static loading testing result suggests that design of the bridge meets the utilization requirements.

  14. Effect of reversion treatment on strength and ductility of low C, Cr-Ni martensitic stainless steel with high resistance to weld softening. Yosetsu nanka teiko no takai teitanso Cr-Ni maruten saito kei stainless ko no kyodo, ensei ni oyobosu gyaku hentai shori no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Igawa, T.; Takemoto, T.; Uematsu, Y. (Nisshin Steel Co. Ltd., Tokyo (Japan). Steel R and D Lab.); Hoshino, K. (Nisshin Steel Co. Ltd., Tokyo (Japan))

    1993-08-01

    Like the stainless steel and the stainless steel belt used in the rolling stock, materials treated by process and weld has a high strength and a good ductility, moreover, was expected that weld softening would not occurred. In this study, formation of the ultra-fine crystal grains based on the M to [gamma] reversion transformation of low C, Cr-Ni martensitic stainless steel and effect of Si on change of mechanical properties were investigated. A high-strength stainless steel with a good ductility and without weld softening was developed. Main results obtained are as follows: After a steel was cold-rolled, the reversion treatment at the region between As and Af temperatures (600 to 640[degree]C) was carried out, a duplex structure with diameter of the ultra-fine grains of about 0.5 micron meter that is composed of [gamma] phase concentrated Ni and sintered M phase was formatted, and excellent mechanical properties with a high strength and a good ductility could be obtained, diameter of reversion [gamma] grains was dependent on reversion temperature. Diameter of [gamma] grains became large, and more homogeneous and uniform at higher reversion temperature. 20 refs., 11 figs., 2 tabs.

  15. The effects of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP) during a single bout of high resistance exercise in resistance trained young men.

    Science.gov (United States)

    Velloso, C P; Aperghis, M; Godfrey, R; Blazevich, A J; Bartlett, C; Cowan, D; Holt, R I G; Bouloux, P; Harridge, S D R; Goldspink, G

    2013-06-01

    Recombinant human growth hormone (rhGH) is used by some athletes and body builders with the aim of enhancing performance, building muscle and improving physique. Detection of the misuse of rhGH has proved difficult for a number of reasons. One of these is the effect of preceding exercise. In this randomised, double blind placebo-controlled study, we determined the effects of rhGH administration in male amateur athletes on two candidate markers of rhGH abuse, IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP), following a bout of weightlifting exercise. Sixteen men entered a four-week general weight training programme to homogenise their activity profile. They then undertook repeated bouts of standardised leg press weightlifting exercise (AHRET-acute heavy resistance exercise test). Blood samples were taken before and up to one hour after the AHRET. After the first laboratory visit (Test 1), the subjects were randomly assigned to receive daily injections of either rhGH (0.1 IU kg(-1) day(-1)) or placebo for two weeks. The AHRET was repeated after the two-week dosing period (Test 2) and a further test was undertaken following a one-week washout (Test 3). There was no effect of exercise on either IGF-I or P-III-NP in any test. Both markers were markedly elevated at Test 2 (pP-III-NP remaining elevated at Test 3 in the GH administration group (pP-III-NP in well-trained individuals and that leg press weightlifting exercise does not affect these markers. The GH-2000 discriminant function identified four of eight subjects taking rhGH with no false positive results. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Rapid precision casting for complex thin-walled aluminum alloy parts

    Directory of Open Access Journals (Sweden)

    Xuanpu DONG

    2004-11-01

    Full Text Available Based on Vacuum Differential Pressure Casting (VDPC precision forming technology and the Selective Laser Sintering (SLS Rapid Prototyping (RP technology, a rapid manufacturing method called Rapid Precision Casting (RPC process from computer three-dimensional solid models to metallic parts was investigated. The experimental results showed that the main advantage of RPC was not only its ability to cast higher internal quality and more accurate complex thin-walled aluminum alloy parts, but also the greatly-reduced lead time cycle from Selective Laser Sintering(SLS plastic prototyping to metallic parts. The key forming technology of RPC for complex thin-walled metallic parts has been developed for new casting production and Rapid Tooling (RT, and it is possible to rapidly manufacture high-quality and accurate metallic parts by means of RP in foundry industry.

  17. Operation and performance of the CMS Resistive Plate Chambers during LHC run II

    CERN Document Server

    Eysermans, Jan

    2017-01-01

    The Resitive Plate Chambers (RPC) at the Compact Muon Solenoid (CMS) experiment at the CERN Large Hadron Collider (LHC) provide redundancy to the Drift Tubes in the barrel and Cathode Strip Chambers in the endcap regions. Consisting of 1056 double gap RPC chambers, the main detector parameters and environmental conditions are carefully monitored during the data taking period. At a center of mass energy of 13 TeV, the luminosity reached record levels which was challenging from the operational and performance point of view. In this work, the main operational parameters are discussed and the overall performance of the RPC system is reported for the LHC run II data taking period. With a low amount of inactive chambers, a good and stable detector performance was achieved with high efficiency.

  18. The effect of polypropylene fiber on mechanical properties of reactive powder concrete

    Science.gov (United States)

    Saloma, Hanafiah, Putra, Fungki Nopreal

    2017-09-01

    Reactive Powder Concrete (RPC) was known as concrete with very dense in microstructure and having high value in compressive strength due to the utilization of very fine materials. One of the weakness of RPC is very brittle. To improve the ductility could used polypropylene fiber. In this research, the various weight of the polypropylene fiber used were 0.4 kg, 0.6 kg, and 0.8 kg per cubic metre of concrete. From this study, RPC mixture with 0.8 kg polypropylene fiber yielded maximum value, e.g the compressive strength was 103.253 MPa, modulus of elasticity was 45.252 MPa, splitting tensile strength was 5.91 MPa, and flexural strength was 9.56 MPa.

  19. Two-Color Strong-Field Photoelectron Spectroscopy and the Phase of the Phase.

    Science.gov (United States)

    Skruszewicz, S; Tiggesbäumker, J; Meiwes-Broer, K-H; Arbeiter, M; Fennel, Th; Bauer, D

    2015-07-24

    The presence of a weak second-harmonic field in an intense-laser ionization experiment affects the momentum-resolved electron yield, depending on the relative phase between the ω and the 2ω component. The proposed two-color "phase-of-the-phase spectroscopy" quantifies for each final electron momentum a relative-phase contrast (RPC) and a phase of the phase (PP) describing how much and with which phase lag, respectively, the yield changes as a function of the relative phase. Experimental results for RPC and PP spectra for rare gas atoms and CO_{2} are presented. The spectra demonstrate a rather universal structure that is analyzed with the help of a simple model based on electron trajectories, wave-packet spreading, and (multiple) rescattering. Details in the PP and RPC spectra are target sensitive and, thus, may be used to extract structural (or even dynamical) information with high accuracy.

  20. Web-based monitoring tools for Resistive Plate Chambers in the CMS experiment at CERN

    Science.gov (United States)

    Kim, M. S.; Ban, Y.; Cai, J.; Li, Q.; Liu, S.; Qian, S.; Wang, D.; Xu, Z.; Zhang, F.; Choi, Y.; Kim, D.; Goh, J.; Choi, S.; Hong, B.; Kang, J. W.; Kang, M.; Kwon, J. H.; Lee, K. S.; Lee, S. K.; Park, S. K.; Pant, L. M.; Mohanty, A. K.; Chudasama, R.; Singh, J. B.; Bhatnagar, V.; Mehta, A.; Kumar, R.; Cauwenbergh, S.; Costantini, S.; Cimmino, A.; Crucy, S.; Fagot, A.; Garcia, G.; Ocampo, A.; Poyraz, D.; Salva, S.; Thyssen, F.; Tytgat, M.; Zaganidis, N.; Doninck, W. V.; Cabrera, A.; Chaparro, L.; Gomez, J. P.; Gomez, B.; Sanabria, J. C.; Avila, C.; Ahmad, A.; Muhammad, S.; Shoaib, M.; Hoorani, H.; Awan, I.; Ali, I.; Ahmed, W.; Asghar, M. I.; Shahzad, H.; Sayed, A.; Ibrahim, A.; Aly, S.; Assran, Y.; Radi, A.; Elkafrawy, T.; Sharma, A.; Colafranceschi, S.; Abbrescia, M.; Calabria, C.; Colaleo, A.; Iaselli, G.; Loddo, F.; Maggi, M.; Nuzzo, S.; Pugliese, G.; Radogna, R.; Venditti, R.; Verwilligen, P.; Benussi, L.; Bianco, S.; Piccolo, D.; Paolucci, P.; Buontempo, S.; Cavallo, N.; Merola, M.; Fabozzi, F.; Iorio, O. M.; Braghieri, A.; Montagna, P.; Riccardi, C.; Salvini, P.; Vitulo, P.; Vai, I.; Magnani, A.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Aleksandrov, A.; Genchev, V.; Iaydjiev, P.; Rodozov, M.; Sultanov, G.; Vutova, M.; Stoykova, S.; Hadjiiska, R.; Ibargüen, H. S.; Morales, M. I. P.; Bernardino, S. C.; Bagaturia, I.; Tsamalaidze, Z.; Crotty, I.

    2014-10-01

    The Resistive Plate Chambers (RPC) are used in the CMS experiment at the trigger level and also in the standard offline muon reconstruction. In order to guarantee the quality of the data collected and to monitor online the detector performance, a set of tools has been developed in CMS which is heavily used in the RPC system. The Web-based monitoring (WBM) is a set of java servlets that allows users to check the performance of the hardware during data taking, providing distributions and history plots of all the parameters. The functionalities of the RPC WBM monitoring tools are presented along with studies of the detector performance as a function of growing luminosity and environmental conditions that are tracked over time.

  1. Web-based monitoring tools for Resistive Plate Chambers in the CMS experiment at CERN

    CERN Document Server

    Kim, Min Suk

    2014-01-01

    The Resistive Plate Chambers (RPC) are used in the CMS experiment at the trigger level and also in the standard offline muon reconstruction. In order to guarantee the quality of the data collected and to monitor online the detector performance, a set of tools has been developed in CMS which is heavily used in the RPC system. The Web-based monitoring (WBM) is a set of java servlets that allows users to check the performance of the hardware during data taking, providing distributions and history plots of all the parameters. The functionalities of the RPC WBM monitoring tools are presented along with studies of the detector performance as a function of growing luminosity and environmental conditions that are tracked over time.

  2. Legume seeds and rapeseed press cake as substitutes for soybean meal in sow and piglet feed

    Directory of Open Access Journals (Sweden)

    Ewa Hanczakowska

    2013-11-01

    Full Text Available The possibility of replacing soybean meal with mixtures of rapeseed press cake (RPC and legume seeds in sow and piglet diets was evaluated in an experiment on 30 sows and their progeny. Group I (control received standard feed mixture containing soybean meal as the main protein source, group II – RPC mixed with fodder pea, group III – field bean, group IV – blue lupine, group V – yellow lupine. Weaned piglets received mixtures containing RPC and legume mixtures. Considerable differences were found in amino acid composition of proteins. Differences in the apparent digestibility of essential nutrients were statistically insignificant. Sows fed with field bean and yellow lupine gave birth to heaviest piglets. After weaning piglets receiving field bean were characterized by the best weight gains. It is concluded that mixing rapeseed cake with legume seeds allows for the complete replacement of soybean meal in sow diets and for partial replacement in piglet diets.

  3. Performance of the ATLAS Level-1 muon barrel trigger during the Run 2 data taking

    CERN Document Server

    Sessa, Marco; The ATLAS collaboration

    2017-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. It exploits the Resistive Plate Chambers (RPC) detectors to generate the trigger signal. The RPCs are placed in the barrel region of the ATLAS experiment: they are arranged in three concentric double layers and operate in a strong magnetic toroidal field. RPC detectors cover the pseudo-rapidity range |η| < 1.05 for a total surface of more than 4000 m 2 and about 3600 gas volumes. The Level-1 Muon Trigger in the barrel region allows to select muon candidates according to their transverse momentum and associates them with the correct bunch-crossing. The trigger system is able to take a decision within a latency of about 2 μs. The measurement of the RPC detector efficiencies and the trigger performance during the ATLAS Run-II data taking are here presented.

  4. Development of RE1/1 RPCs for the CMS muon trigger system

    CERN Document Server

    Park, S; Akimenko, S; Anan, P S; Bahk, S Y; Ban, Y; Cai, J; Cho, S W; Crotty, I; Ge, Y C; Hong, B; Hong, S J; Iaselli, G; Ito, M; Jonalegedda, S; Kang, T I; Kim, B I; Kim, H C; Kim, J H; Kim, T J; Kim, Y J; Kim, Y U; Koo, D G; Kuo, R; Lee, H S; Lee, K B; Lee, K S; Lee, S J; Lim, J K; Liu, H; Marinov, A; Nam, S K; Qian, S J; Rhee, H B; Rhee, J T; Ryu, M S; Sharma, A; Sim, K S; Van Doninck,W; Xue, Z H

    2009-01-01

    The first six Resistive Plate Chambers (RPCs) of RE1/1 in the forward region of the Compact Muon Solenoid (CMS) detector were constructed and are being tested. These RPCs cover the pseudo-rapidity region from 1.6 to 2.1 and will serve as the base detector for the CMS RPC muon trigger. We report that these six RPCs are being tested with the CMS RPC quality certification procedures and that a full measurement of a chamber efficiency of 95±4% has been achieved at an operating voltage of 9.4 kV. This performance demonstrates that the RPC is qualified to be tested at the closest distance to the beam pipe as the muon trigger detector at the full LHC design luminosity.

  5. Flexural Behavior of Continuous Bubbled Reinforced Reactive Powder Concrete Flat Slab

    Directory of Open Access Journals (Sweden)

    Mohammad Redha K. Mahmood

    2017-05-01

    Full Text Available This paper presents an experimental investigation on flexural behavior of continuous bubbled reinforced Reactive Powder Concrete (RPC flat slabs. Bubbled slab is one of the various types of voided slabs. It consist of bubbles placed inside a concrete slab which will reduce the self-weight of the structure by about 35% (Tina Lai 2009. On the other hand, using RPC make it possible for structural member to have smaller dimensions due to the great strength of this type of concrete. In this study these two method are used to increase the building spaces dimensions by reducing self-weigh of the structure by using bubbled slabs and to decrease the structural members' dimensions by using RPC have been investigated together. To study the flexural behavior of continuous bubbled flat slabs such as the ultimate load carrying capacity, central deflection and slabs crack pattern at the ultimate load, seven types of slabs were tested. The parameters of the study were type of concrete (RPC and Normal Concrete (NC, bubbles diameter to slab thickness ratio (D/t of (0.6 and 0.7, type of loading (distributed and line load and solid slab. The test results show that the crack pattern and ultimate load capacity as well as maximum deflection depends on all of the mentioned parameters, were by increasing (D/t ratio the ultimate load capacity increases about (7.36%, 5.46% and 16.52% for RPC slabs under distributed load, line load and NC slabs, respectively. The solid slab increases the ultimate load about (4.05% compare to bubbled slab. Also, the line load decreases the ultimate load compare to distributed load by (3.45-5.16% for different (D/t ratio, and using the NC also decreases the ultimate load compare to RPC by (48-52.13% for different (D/t ratio

  6. Vertical structure of the near-surface expanding ionosphere of comet 67P probed by Rosetta

    Science.gov (United States)

    Heritier, K. L.; Henri, P.; Vallières, X.; Galand, M.; Odelstad, E.; Eriksson, A. I.; Johansson, F. L.; Altwegg, K.; Behar, E.; Beth, A.; Broiles, T. W.; Burch, J. L.; Carr, C. M.; Cupido, E.; Nilsson, H.; Rubin, M.; Vigren, E.

    2017-07-01

    The plasma environment has been measured for the first time near the surface of a comet. This unique data set has been acquired at 67P/Churyumov-Gerasimenko during ESA/Rosetta spacecraft's final descent on 2016 September 30. The heliocentric distance was 3.8 au and the comet was weakly outgassing. Electron density was continuously measured with Rosetta Plasma Consortium (RPC)-Mutual Impedance Probe (MIP) and RPC-LAngmuir Probe (LAP) during the descent from a cometocentric distance of 20 km down to the surface. Data set from both instruments have been cross-calibrated for redundancy and accuracy. To analyse this data set, we have developed a model driven by Rosetta Orbiter Spectrometer for Ion and Neutral Analysis-COmetary Pressure Sensor total neutral density. The two ionization sources considered are solar extreme ultraviolet radiation and energetic electrons. The latter are estimated from the RPC-Ion and Electron Sensor (IES) and corrected for the spacecraft potential probed by RPC-LAP. We have compared the results of the model to the electron densities measured by RPC-MIP and RPC-LAP at the location of the spacecraft. We find good agreement between observed and modelled electron densities. The energetic electrons have access to the surface of the nucleus and contribute as the main ionization source. As predicted, the measurements exhibit a peak in the ionospheric density close to the surface. The location and magnitude of the peak are estimated analytically. The measured ionospheric densities cannot be explained with a constant outflow velocity model. The use of a neutral model with an expanding outflow is critical to explain the plasma observations.

  7. TU-C-BRE-05: Clinical Implications of AAA Commissioning Errors and Ability of Common Commissioning ' Credentialing Procedures to Detect Them

    Energy Technology Data Exchange (ETDEWEB)

    McVicker, A; Oldham, M; Yin, F; Adamson, J [Duke University Medical Center, Durham, NC (United States)

    2014-06-15

    Purpose: To test the ability of the TG-119 commissioning process and RPC credentialing to detect errors in the commissioning process for a commercial Treatment Planning System (TPS). Methods: We introduced commissioning errors into the commissioning process for the Anisotropic Analytical Algorithm (AAA) within the Eclipse TPS. We included errors in Dosimetric Leaf Gap (DLG), electron contamination, flattening filter material, and beam profile measurement with an inappropriately large farmer chamber (simulated using sliding window smoothing of profiles). We then evaluated the clinical impact of these errors on clinical intensity modulated radiation therapy (IMRT) plans (head and neck, low and intermediate risk prostate, mesothelioma, and scalp) by looking at PTV D99, and mean and max OAR dose. Finally, for errors with substantial clinical impact we determined sensitivity of the RPC IMRT film analysis at the midpoint between PTV and OAR using a 4mm distance to agreement metric, and of a 7% TLD dose comparison. We also determined sensitivity of the 3 dose planes of the TG-119 C-shape IMRT phantom using gamma criteria of 3% 3mm. Results: The largest clinical impact came from large changes in the DLG with a change of 1mm resulting in up to a 5% change in the primary PTV D99. This resulted in a discrepancy in the RPC TLDs in the PTVs and OARs of 7.1% and 13.6% respectively, which would have resulted in detection. While use of incorrect flattening filter caused only subtle errors (<1%) in clinical plans, the effect was most pronounced for the RPC TLDs in the OARs (>6%). Conclusion: The AAA commissioning process within the Eclipse TPS is surprisingly robust to user error. When errors do occur, the RPC and TG-119 commissioning credentialing criteria are effective at detecting them; however OAR TLDs are the most sensitive despite the RPC currently excluding them from analysis.

  8. Development and Implementation of the DHAPP Military eHealth Information Network System

    Science.gov (United States)

    2016-03-01

    standards. DHAPP worked with the private sector to develop a commercial-off-the- shelf (COTS) electronic medical record (EMR) for the collection of data...Carib- bean. The result is a continuously evolving, easy-to-use, commercial-off-the- shelf EMR application that focuses on (1) improving the levels...JSON, JSON-RPC, REST, XML-RPC W3C and SOA standards (NAMRU-6 and JHU/APL) Database management system MySQL and MongoDB Smart synchronization

  9. Punching Shear Behavior of Continuous Bubbled Reinforced Reactive Powder Concrete Slab

    OpenAIRE

    Mohammad Redha K. Mahmood; Dawood, Mustafa B.

    2017-01-01

    This paper presents an experimental investigation on punching shear behavior of continuous bubbled reinforced Reactive Powder Concrete (RPC) slabs. Bubbled slab is one of the various types of voided slabs. It consists of bubbles placed inside a concrete slab which will reduce the self-weight of the structure by about 35% (Tina Lai 2009). On the other hand, using RPC make it possible for structural member to have smaller dimensions due to the great strength of this type of concrete. In this st...

  10. Flexural Behavior of Continuous Bubbled Reinforced Reactive Powder Concrete Flat Slab

    OpenAIRE

    Mohammad Redha K. Mahmood; Dawood, Mustafa B.

    2017-01-01

    This paper presents an experimental investigation on flexural behavior of continuous bubbled reinforced Reactive Powder Concrete (RPC) flat slabs. Bubbled slab is one of the various types of voided slabs. It consist of bubbles placed inside a concrete slab which will reduce the self-weight of the structure by about 35% (Tina Lai 2009). On the other hand, using RPC make it possible for structural member to have smaller dimensions due to the great strength of this type of concrete. In this stud...

  11. Regulation of Nutritional Metabolism in Transition Dairy Cows: Energy Homeostasis and Health in Response to Post-Ruminal Choline and Methionine.

    Directory of Open Access Journals (Sweden)

    Feifei Sun

    Full Text Available This study investigated the effects of rumen-protected methionine (RPM and rumen-protected choline (RPC on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum. Postpartum dry matter intake (DMI was increased by both additives (P < 0.05, and energy balance values in supplemented cows were improved after parturition (P < 0.05. Both RPC and RPM decreased the plasma concentrations of non-esterified fatty acids (NEFA, β-hydroxybutyric acid (BHBA, total cholesterol (TC and low-density lipoprotein cholesterol (LDL-C (P < 0.05, but increased the plasma levels of glucose, very-low-density lipoprotein (VLDL and apolipoprotein B100 (ApoB 100, P < 0.05. The supplements improved milk production (P < 0.05, and increased (P < 0.05 or tended to increase (0.05 < P < 0.10 the contents of milk fat and protein. The post-ruminal choline and methionine elevated the blood antioxidant status, as indicated by total antioxidant capacity (T-AOC, glutathione peroxidase (GSH-Px activity and the vitamin E concentration (P < 0.05, and reduced the plasma malondialdehyde (MDA level (P < 0.05. Furthermore, RPM and RPC elevated the plasma interleukin 2 (IL-2 concentration and the CD4+/CD8+ T lymphocyte ratio in peripheral blood (P < 0.05. Alternatively, the levels of tumor necrosis factor-α (TNF-α and IL-6 were decreased by RPM and RPC (P < 0.05. Overall, the regulatory responses of RPC and RPM were highly correlated with time and were more effective in the postpartum cows. The results demonstrated that dietary supplementation with RPC and RPM promoted energy balance by increasing postpartal DMI

  12. Time resolution of resistive plate chambers investigated with 10 MeV electrons

    Energy Technology Data Exchange (ETDEWEB)

    Paradela, C., E-mail: carlos.paradela@usc.es [Universidad de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Ayyad, Y.; Benlliure, J. [Universidad de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Casarejos, E. [Universidad de Vigo, E-36310 Vigo (Spain); Duran, I. [Universidad de Santiago de Compostela, E-15782, Santiago de Compostela (Spain)

    2014-01-21

    The time resolution of double-gap timing resistive plate chambers (tRPC) has been measured with 10 MeV electron bunches of variable intensity. The use of electrons delivered in bunches of a few picoseconds was an attempt to mimic the energy deposition of heavy ions in the tRPC gas gap. The measurements show a clear dependence of the time resolution with the number of electrons per bunch, reaching 21 ps (standard deviation) for the highest beam intensity. The signal charge distribution and the time resolution are compared to data obtained with the same detectors for cosmic rays and {sup 238}U ions at 1 AGeV.

  13. Tumores primarios múltiples en el Área Metropolitana de Bucaramanga

    OpenAIRE

    Rafael Miguel Camacho López; Dinora Yoana León Camargo; Fabián Leonardo Escudero Sepúlveda; Claudia Janeth Uribe Pérez, MD

    2010-01-01

    Introducción: El objetivo es determinar las características epidemiológicas de los tumores primarios múltiples (TPM) en la población del área metropolitana de Bucaramanga (AMB) de acuerdo a la información del Registro Poblacional de Cáncer del Área Metropolitana de Bucaramanga (RPC-AMB) durante los años 2000 a 2004. Métodos: Se utilizaron los datos del RPC-AMB, seleccionándose los casos quecumplían todos los criterios de inclusión para TPM. Los datos obtenidos fueron analizados teniendo en cu...

  14. Gclust Server: 187918 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 187918 Rpa3_RPC_1339 Cluster Sequences - 93 hypothetical protein 1 1.00e-45 0.0 0.0... 0.0 6.67 0.0 0.0 Show 187918 Cluster ID 187918 Sequence ID Rpa3_RPC_1339 Link to cluster sequences Cluster ...er of Sequences 1 Homologs 1 Clustering threshold 1.00e-45 Plants and algae (7spe... Species not appearing in this cluster ATH: 0 OSA: 0 PoTR: 0 PPT: 0 CRE: 0 OTAU: 0 CME: 0 GTH: 0 PFA: 0 PTR:

  15. Rumen-protected choline: A significance effect on dairy cattle nutrition

    Directory of Open Access Journals (Sweden)

    G. Jayaprakash

    2016-08-01

    Full Text Available Choline is a vitamin-like substance it has multi-function in animal production, reproduction, and health. The transition period is most crucial stage in lactation cycle of dairy cows due to its association with negative hormonal and energy balances. Unfortunately, unprotected choline easily degrades in the rumen; therefore, choline added to the diet in a rumenprotected form. The use of rumen-protected choline (RPC is a preventive measurement for the fatty liver syndrome and ketosis; may improve milk production as well as milk composition and reproduction parameters. This review summarizes the effectiveness of RPC on animal production, health, and reproduction.

  16. China e países do Sudoeste Asiático versus Japão: uma aliança estratégica em defesa do status quo

    OpenAIRE

    Graça, Magda Teixeira

    2010-01-01

    Depois de ter alcançado o reconhecimento internacional como membro permanente do CSNU, em detrimento de Taiwan, em 1971, a RPC, volvidas quase quatro décadas, tem um novo desafio a enfrentar. O Japão prepara-se para se candidatar a membro permanente do CSNU e a China poderá vir a ter de partilhar a liderança regional com um velho invasor. Barry O’Neill identificou a RPC, de entre os países que integram o círculo dos membros permanentes do CSNU, como sendo o membro que detém ...

  17. Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis

    DEFF Research Database (Denmark)

    Hansen, HG; Overgaard, J; Lajer, M

    2010-01-01

    with a MALDI-TOF-MS readout were successfully established. Using these protocols and a combined univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical analysis approach, ten single peptides and three multi-peptide candidate biomarkers were found. Employment of RPC18 and weak...

  18. Gclust Server: 19876 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 19876 Rpa3_RPC_2913 Cluster Sequences Related Sequences(54) 347 PpiC-type peptidyl-...prolyl cis-trans isomerase 5 1.00e-90 0.0 0.0 0.0 26.67 0.0 0.0 Show 19876 Cluster ID 19876 Sequence ID Rpa3

  19. Angular distribution of cosmic muons using INO–ICAL prototype ...

    Indian Academy of Sciences (India)

    2015-11-27

    Nov 27, 2015 ... The India-based Neutrino Observatory Collaboration is planning to set up a magnetized 50 kt iron calorimeter (ICAL) with resistive plate chambers (RPC) as active detectors to study neutrino oscillations and precisely measure its parameters. A prototype detector stack is set up at TIFR (18°54'N, 72°48'E) to ...

  20. One Size Fits All: Perceptions of the Revised Primary Curriculum at Grades One to Three in Jamaica

    Science.gov (United States)

    Roofe, Carmel G.

    2014-01-01

    The attainment of Education for All (EFA) goals is crucial to the productivity of any country. However attaining these goals cannot be realised unless due consideration is given to the inputs and processes that must be enacted to achieve such goals. In this article, the Revised Primary Curriculum (RPC) used at grades one to three in Jamaican…

  1. Performance of CMS Resistive Plate Chambers in CRAFT and early 2015 collisions at 13 TeV

    CERN Document Server

    CMS Collaboration

    2015-01-01

    Resistive Plate Chambers (RPC) performance results with cosmics data at 3.8 T and p-p collision data at 13 TeV for 2015 are presented. These results include plots of relevant RPC variables such as occupancy, cluster size, efficiency and residuals. RPC cluster size, measured with cosmic rays at 3.8 T during 2015, is presented and compared with 2012 results. During the first long shutdown of the LHC (2013-2014) the CMS muon system has been upgraded with 144 double-gap chambers on the forth forward stations. During the commissioning period, the system has been successfully run and experimental data has been collected and analyzed in details. Occupancy and efficiency results of newly installed chambers using 13 TeV p-p data are reported. The results of the 2015 HV Scan, performed at 0 T magnetic field, are presented and compared with the 2012 HV scan results at 3.8 T. These results are comparable since RPC efficiency is independent of the magnetic field surrounding the chambers.

  2. Preliminary results from India-based Neutrino Observatory detector ...

    Indian Academy of Sciences (India)

    Abstract. We are currently developing and studying the performance of glass RPC pro- totypes, under the INO detector R&D programme. While we were successful in building and characterising a large number of chambers using local glass, these have met with severe aging problems after a few months of continuous ...

  3. Preliminary results from India-based Neutrino Observatory detector ...

    Indian Academy of Sciences (India)

    We are currently developing and studying the performance of glass RPC prototypes, under the INO detector R & D programme. While we were successful in building and characterising a large number of chambers using local glass, these have met with severe aging problems after a few months of continuous operation.

  4. Resonance parameter and covariance evaluation for 16O up to 6 MeV

    Directory of Open Access Journals (Sweden)

    Leal Luiz

    2016-01-01

    Full Text Available A resolved resonance evaluation was performed for 16O in the energy range 0 eV to 6 MeV using the computer code SAMMY resulting in a set of resonance parameters (RPs that describes well the experimental data used in the evaluation. A RP covariance matrix (RPC was also generated. The RP were converted to the evaluated nuclear data file format using the R-Matrix Limited format and the compact format was used to represent the RPC. In contrast to the customary use of RP, which are frequently intended for the generation of total, capture, and scattering cross sections only, the present RP evaluation permits the computation of angle dependent cross sections. Furthermore, the RPs are capable of representing the (n, α cross section from the energy threshold (2.354 MeV of the (n, α reaction to 6 MeV. The intent of this paper is to describe the procedures used in the evaluation of the RP and RPC, the use of the RPC in benchmark calculations and to assess the impact of the 16O nuclear data uncertainties in the calculate dkeff for critical benchmark experiments.

  5. Background neutron in the endcap and barrel regions of resistive ...

    Indian Academy of Sciences (India)

    The detector response calculations taken as a function of the neutron energy in the range of 0.01 eV–1 GeV have been simulated through RPC set-up. In order to evaluate the response of detector in the LHC background environment, the neutron spectrum expected in the CMS muon endcap and barrel region were taken ...

  6. Performance of the Amoeba Distributed Operating System

    NARCIS (Netherlands)

    van Renesse, R.; van Staveren, H.; Tanenbaum, A.S.

    1989-01-01

    Amoeba is a capability‐based distributed operating system designed for high‐performance interactions between clients and servers using the well‐known RPC model. The paper starts out by describing the architecture of the Amoeba system, which is typified by specialized components such as workstations,

  7. Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics.

    Science.gov (United States)

    Valeja, Santosh G; Xiu, Lichen; Gregorich, Zachery R; Guner, Huseyin; Jin, Song; Ge, Ying

    2015-01-01

    To address the complexity of the proteome in mass spectrometry (MS)-based top-down proteomics, multidimensional liquid chromatography (MDLC) strategies that can effectively separate proteins with high resolution and automation are highly desirable. Although various MDLC methods that can effectively separate peptides from protein digests exist, very few MDLC strategies, primarily consisting of 2DLC, are available for intact protein separation, which is insufficient to address the complexity of the proteome. We recently demonstrated that hydrophobic interaction chromatography (HIC) utilizing a MS-compatible salt can provide high resolution separation of intact proteins for top-down proteomics. Herein, we have developed a novel 3DLC strategy by coupling HIC with ion exchange chromatography (IEC) and reverse phase chromatography (RPC) for intact protein separation. We demonstrated that a 3D (IEC-HIC-RPC) approach greatly outperformed the conventional 2D IEC-RPC approach. For the same IEC fraction (out of 35 fractions) from a crude HEK 293 cell lysate, a total of 640 proteins were identified in the 3D approach (corresponding to 201 nonredundant proteins) as compared to 47 in the 2D approach, whereas simply prolonging the gradients in RPC in the 2D approach only led to minimal improvement in protein separation and identifications. Therefore, this novel 3DLC method has great potential for effective separation of intact proteins to achieve deep proteome coverage in top-down proteomics.

  8. CMPLServer - An open source approach for distributed and grid optimisation

    OpenAIRE

    Steglich, Mike

    2016-01-01

    This paper describes CMPLServer, an XML-RPC-based web service for distributed and grid optimisation for CMPL (Coin|Coliop Mathematical Programming Language) which is a mathematical programming language as well as a system for mathematical programming and optimisation of linear optimisation problems.

  9. Gclust Server: 181882 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 181882 Rpa3_RPC_2035 Cluster Sequences - 312 alpha/beta hydrolase fold 1 1.00e-99 0.0 0.0 0.0 6.67 0.0...Sequence length 312 Representative annotation alpha/beta hydrolase fold Number of Sequences 1 Homologs

  10. Experimental Research on Fire Resistance of Reactive Powder Concrete

    Directory of Open Access Journals (Sweden)

    Gai-Fei Peng

    2012-01-01

    Full Text Available An experimental investigation was conducted on fire resistance of reactive powder concrete (RPC, mainly on explosive spalling occurrence and residual mechanical properties exposed to high temperature. The residual mechanical properties measured include compressive strength, tensile splitting strength, and fracture energy. RPC was prepared using cement, sand, silica fume, steel fiber, and polypropylene fiber. After subjected to high temperatures from 200 to 600°C, the residual mechanical properties were determined. RPC spalled considerably under high temperature. After exposure to high temperatures from 200 to 400°C, mechanical properties were enhanced more or less, which can be attributed to further hydration of cementitious materials activated by elevated temperature. Compressive strength started to decrease after exposure to 400°C, but tensile splitting strength and fracture energy started to decrease after exposure to 200°C. Incorporating hybrid fiber (polypropylene fiber and steel fiber is a promising way to enhance resistance of RPC to explosive spalling, which should be a main objective for improving its fire resistance.

  11. Background neutron in the endcap and barrel regions of resistive ...

    Indian Academy of Sciences (India)

    Resistive plate chamber; background radiation; Monte Carlo simulation. PACS Nos 29.40. ... the RPC double-gap tri-dimensional geometry by means of GEANT4 Monte Carlo code. 378. Pramana – J. Phys. ..... [10] D E Cullen and S M Seltzer, Tables and graphs of electron interaction cross-sections from 10 eV to 100 GeV ...

  12. 75 FR 51859 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-08-23

    ... disseminated via the consolidated tape. (4) RPC orders will be allocated on a pro-rata basis, such that shares will be allocated pro-rata in round lots to eligible orders based on the original size of the order. If additional shares remain after the initial pro-rata allocation, those shares will continue to be allocated...

  13. Experiment list: SRX150568 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available is=Adenocarcinoma 59265240,72.4,16.4,4779 GSM935489: Harvard ChipSeq HeLa-S3 RPC155 std source_name=HeLa-S3 ...|| biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipS

  14. Experiment list: SRX150452 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available s=Leukemia Chronic Myelogenous 17157530,93.1,18.0,2344 GSM935372: Harvard ChipSeq K562 RPC155 std source_nam...e=K562 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatyp

  15. Marijuana and acute health care contacts in Colorado.

    Science.gov (United States)

    Wang, George Sam; Hall, Katelyn; Vigil, Daniel; Banerji, Shireen; Monte, Andrew; VanDyke, Mike

    2017-03-30

    Over 22 million Americans are current users of marijuana; half of US states allow medical marijuana, and several allow recreational marijuana. The objective of this study was to evaluate the impact marijuana has on hospitalizations, emergency department (ED) visits, and regional poison center (RPC) calls in Colorado, a medical and recreational marijuana state. This is a retrospective review using Colorado Hospital Association hospitalizations and ED visits with marijuana-related billing codes, and RPC marijuana exposure calls. Legalization of marijuana in Colorado has been associated with an increase in hospitalizations, ED visits, and RPC calls linked with marijuana exposure. From 2000 to 2015, hospitalization rates with marijuana-related billing codes increased from 274 to 593 per 100,000 hospitalizations in 2015. Overall, the prevalence of mental illness among ED visits with marijuana-related codes was five-fold higher (5.07, 95% CI: 5.0, 5.1) than the prevalence of mental illness without marijuana-related codes. RPC calls remained constant from 2000 through 2009. However, in 2010, after local medical marijuana policy liberalization, the number of marijuana exposure calls significantly increased from 42 to 93; in 2014, after recreational legalization, calls significantly increased by 79.7%, from 123 to 221 (pmarijuana, it is important to address public education and youth prevention, and understand the impact on mental health disorders. Improvements in data collection and surveillance methods are needed to more accurately evaluate the public health impact of marijuana legalization. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. High Performance Liquid Chromatographic Analysis of Phytoplankton Pigments Using a C16-Amide Column

    Science.gov (United States)

    A reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed to analyze in a single run, most polar and non-polar chlorophylls and carotenoids from marine phytoplankton. The method is based on a RP-C16-Amide column and a ternary gradient system consistin...

  17. AcEST: DK948493 [AcEST

    Lifescience Database Archive (English)

    Full Text Available C C + C+GFL Sbjct: 1249 RIPCLCGTPACKGFL 1263 >tr|A6S0T3|A6S0T3_BOTFB Putative uncharacterized protein OS=Bot...NEELTYDYKFEREIGSTD 435 Query: 590 RLPCYCKSAECRGFL 634 R+PC C + C+GFL Sbjct: 436 RIPCLCGTPACKGFL 450 ...

  18. High-Rate Fast-Time GRPC for the high eta CMS muon detectors

    CERN Document Server

    Mirabito, Laurent

    2016-01-01

    CMS detector. In their single-gap version we will show that they can stand rates of few ${\\rm kHz/cm}^2$. We also demonstrate that using multi-gap glass RPC, a time resolution of about 60 ps is achieved.

  19. An Experimental Comparison of Remote Procedure Call and Group Communication

    NARCIS (Netherlands)

    Kaashoek, M.F.; Tanenbaum, A.S.; Verstoep, C.

    1992-01-01

    This paper suggests that a distributed system should support two communication paradigms: Remote Procedure Call (RPC) and group communication. The former is used for point-to-point communication; the latter is used for one-to-many communication. We demonstrate that group communication is an

  20. CEMAP II: An Architecture and Specifications to Facilitate the Importing of Real-World Data into the CASOS Software Suite

    Science.gov (United States)

    2008-08-01

    12 7.5 Groupware ...CEMAP II. 7.5 Groupware An important design feature of CEMAP II is the ability for analysts who work in groups to be able to share profiles...https, and even SOAP and RPC web services. Along this same line of groupware , CEMAP II does allow for a soft link to a profile, tableset, or

  1. Gclust Server: 182669 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available Rpa3_RPC_4173 Cluster Sequences - 96 Prevent-host-death protein 1 1.00e-45 0.0 0.0 0.0 6.67 0.0 0.0 Show...length 96 Representative annotation Prevent-host-death protein Number of Sequences 1 Homologs 1 Clustering

  2. Separation of native allophycocyanin and R-phycocyanin from marine red macroalga Polysiphonia urceolata by the polyacrylamide gel electrophoresis performed in novel buffer systems.

    Science.gov (United States)

    Wang, Yu; Gong, Xueqin; Wang, Shumei; Chen, Lixue; Sun, Li

    2014-01-01

    Three buffer systems of Imidazole-Acetic acid, HEPES-Imidazole/Bis-tris and Bis-tris-HEPES-MES were designed based on the principle of discontinuous polyacrylamide gel electrophoresis (PAGE) for the native PAGE which could be performed in pH 7.0 and 6.5 in order to analyze and prepare the minor components of allophycocyanin (AP) and R-phycocyanin (R-PC) from marine red macroalga Polysiphonia urceolata. These AP and R-PC phycobiliproteins are easily denatured in alkaline environments. The obtained results demonstrated that the PAGE modes performed in the buffer systems of HEPES-Imidazole/Bis-tris and Bis-tris-HEPES-MES gave the satisfactory resolution and separation of AP and R-PC proteins. The absorption and fluorescence spectra of the AP and R-PC proteins which were prepared by the established PAGE modes proved that they maintained natural spectroscopic characteristics. The established PAGE modes may also provide useful references and selections for some other proteins that are sensitive to alkaline environments or are not effectively separated by the classical PAGE modes performed normally in alkaline buffer systems.

  3. Separation of native allophycocyanin and R-phycocyanin from marine red macroalga Polysiphonia urceolata by the polyacrylamide gel electrophoresis performed in novel buffer systems.

    Directory of Open Access Journals (Sweden)

    Yu Wang

    Full Text Available Three buffer systems of Imidazole-Acetic acid, HEPES-Imidazole/Bis-tris and Bis-tris-HEPES-MES were designed based on the principle of discontinuous polyacrylamide gel electrophoresis (PAGE for the native PAGE which could be performed in pH 7.0 and 6.5 in order to analyze and prepare the minor components of allophycocyanin (AP and R-phycocyanin (R-PC from marine red macroalga Polysiphonia urceolata. These AP and R-PC phycobiliproteins are easily denatured in alkaline environments. The obtained results demonstrated that the PAGE modes performed in the buffer systems of HEPES-Imidazole/Bis-tris and Bis-tris-HEPES-MES gave the satisfactory resolution and separation of AP and R-PC proteins. The absorption and fluorescence spectra of the AP and R-PC proteins which were prepared by the established PAGE modes proved that they maintained natural spectroscopic characteristics. The established PAGE modes may also provide useful references and selections for some other proteins that are sensitive to alkaline environments or are not effectively separated by the classical PAGE modes performed normally in alkaline buffer systems.

  4. Dicty_cDB: Contig-U06299-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ostelium discoideum chromosome 2 map 6445720... 34 0.095 9 ( EY123531 ) NADL-aaa19f11.g1 Rhodnius_prolix...us_EST_NADL_RpcDN... 36 0.11 2 ( EY123780 ) NADL-aaa19f11.b1 Rhodnius_prolixus_EST_NA

  5. MultiNet TCP/P/IP for VAX/VMS update

    Science.gov (United States)

    Vance, L. Stuart

    1991-01-01

    Outlines of device support; DECnet interoperability; installation; MultiNet services; domain name server; Telnet; FTP; SMTP; DECwindows over TCP/IP; BSD r services; remote printing; RPC services and NFS server; NFS client; netcontrol; diagnostics; programming support; and MultiNet features are presented in viewgraph format.

  6. Retinal progenitor cell xenografts to the pig retina

    DEFF Research Database (Denmark)

    Warfvinge, Karin; Kiilgaard, Jens Folke; Klassen, Henry

    2006-01-01

    -eosin (H&E)-stained sections. Serum samples were taken from naive and RPC-grafted pigs and mouse-reactive antibody responses were assessed. At 1 week, histology showed a few perivascular lymphocytes consistent with a mild retinal vasculitis, and depigmentation of the RPE with large numbers of mononuclear...

  7. Integrating XQuery and P2P in MonetDB/XQuery*

    NARCIS (Netherlands)

    Y. Zhang (Ying); P.A. Boncz (Peter); M. Arenas; J. Hidders

    2007-01-01

    textabstractMonetDB/XQuery* is a fully functional publicly available XML DBMS that has been extended with distributed and P2P data management functionality. Our (minimal) XQuery language extension XRPC adds the concept of RPC to XQuery, and exploits the set-at-a-time database processing model to

  8. N-gram Against the Machine: On the Feasibility of the N-gram Network Analysis for Binary Protocols

    NARCIS (Netherlands)

    Hadziosmanovic, D.; Simionato, Lorenzo; Bolzoni, D.; Zambon, Emmanuele; Etalle, Sandro

    In recent years we have witnessed several complex and high-impact attacks specifically targeting “binary‿ protocols (RPC, Samba and, more recently, RDP). These attacks could not be detected by current – signature-based – detection solutions, while – at least in theory – they could be detected by

  9. Separation of Native Allophycocyanin and R-Phycocyanin from Marine Red Macroalga Polysiphonia urceolata by the Polyacrylamide Gel Electrophoresis Performed in Novel Buffer Systems

    Science.gov (United States)

    Wang, Yu; Gong, Xueqin; Wang, Shumei; Chen, Lixue; Sun, Li

    2014-01-01

    Three buffer systems of Imidazole−Acetic acid, HEPES−Imidazole/Bis-tris and Bis-tris−HEPES−MES were designed based on the principle of discontinuous polyacrylamide gel electrophoresis (PAGE) for the native PAGE which could be performed in pH 7.0 and 6.5 in order to analyze and prepare the minor components of allophycocyanin (AP) and R-phycocyanin (R-PC) from marine red macroalga Polysiphonia urceolata. These AP and R-PC phycobiliproteins are easily denatured in alkaline environments. The obtained results demonstrated that the PAGE modes performed in the buffer systems of HEPES−Imidazole/Bis-tris and Bis-tris−HEPES−MES gave the satisfactory resolution and separation of AP and R-PC proteins. The absorption and fluorescence spectra of the AP and R-PC proteins which were prepared by the established PAGE modes proved that they maintained natural spectroscopic characteristics. The established PAGE modes may also provide useful references and selections for some other proteins that are sensitive to alkaline environments or are not effectively separated by the classical PAGE modes performed normally in alkaline buffer systems. PMID:25166028

  10. Media and Mental Health in Uganda

    African Journals Online (AJOL)

    African Journal of Psychiatry • May 2010. 125. Introduction ... International Development (DfID)(RPC HD6 2005- 2010) for the benefit of developing countries. The views expressed are not ... This article describes the importance accorded to mental health by the media and the factors that influence media coverage of mental ...

  11. Resistive plate chamber online data quality monitoring for the Compact Muon Solenoid at the European Center for Nuclear Research

    CERN Document Server

    Whitaker, William David

    2008-01-01

    A comprehensive, online, data quality monitoring software package has been developed for the muon system at the European Center for Nuclear Research's (CERN's) Compact Muon Solenoid (CMS) experiment. The package was written in Java, C++, and HTML. It provides real-time, RPC performance feedback in an easy to use graphic user interface (GUI).

  12. Direct Shear Behavior of Fiber Reinforced Concrete Elements

    Directory of Open Access Journals (Sweden)

    Hussein Al-Quraishi

    2018-01-01

    Full Text Available Improving the accuracy of load-deformation behavior, failure mode, and ultimate load capacity for reinforced concrete members subjected to in-plane loadings such as corbels, wall to foundation connections and panels need shear strength behavior to be included. Shear design in reinforced concrete structures depends on crack width, crack slippage and roughness of the surface of cracks. This paper illustrates results of an experimental investigation conducted to investigate the direct shear strength of fiber normal strength concrete (NSC and reactive powder concrete (RPC. The tests were performed along a pre-selected shear plane in concrete members named push-off specimens. The effectiveness of concrete compressive strength, volume fraction of steel fiber, and shear reinforcement ratio on shear transfer capacity were considered in this study. Furthermore, failure modes, shear stress-slip behavior, and shear stress-crack width behavior were also presented in this study. Tests’ results showed that volume fraction of steel fiber and compressive strength of concrete in NSC and RPC play a major role in improving the shear strength of concrete. As expectedly, due to dowel action, the shear reinforcement is the predominant factor in resisting the shear stress. The shear failure of NSC and RPC has the sudden mode of failure (brittle failure with the approximately linear behavior of shear stress-slip relationship till failure. Using RPC instead of NSC with the same amount of steel fibers in constructing the push-off specimen result in high shear strength. In NSC, shear strength influenced by the three major factors; crack surface friction, aggregate interlock and steel fiber content if present. Whereas, RPC has only steel fiber and cracks surface friction influencing the shear strength. Due to cementitious nature of RPC in comparisons with NSC, the RPC specimen shows greater cracks width. It is observed that the Mattock model gives very satisfactory

  13. The use of power Doppler colour scoring to predict successful expectant management in women with an incomplete miscarriage.

    Science.gov (United States)

    Casikar, Ishwari; Lu, Chuan; Oates, Jennifer; Bignardi, Tommaso; Alhamdan, Dalya; Condous, George

    2012-03-01

    To evaluate whether the use of power Doppler to confirm the presence or absence of blood flow within retained products of conception (RPC) in women with an incomplete miscarriage can predict subsequent successful expectant management. Prospective observational study in the Acute Gynaecology and Early Pregnancy Unit (AGEPU) at Nepean Hospital from November 2006 to February 2009. Incomplete miscarriage was defined by the presence of a measurable focus of hyperechoeic material, in three planes, within the endometrial cavity using two-dimensional greyscale transvaginal ultrasound (TVS). Subjective qualitative power Doppler colour scoring (PDCS) of the RPC was performed. The vascularization of the RPC was scored using the colour scoring system of the International Ovarian Tumour Analysis (IOTA) group. PDCS 1 meant absence of vascularity, PCDS 2 represented minimal vascularity, PDCS 3 rather strong vascularity and PDCS 4 very strong vascularity. The correlation between the PDCS and successful expectant management of miscarriage was analysed. The volume of RPC was calculated using the ellipsoid formula and then compared with both the PDCS and the outcome of expectant management. Successful expectant management was defined as the resolution of symptoms and the absence of RPC on follow-up TVS. A total of 1395 consecutive pregnant women underwent TVS. Of them, 198 women were diagnosed with an incomplete miscarriage; 172 were managed expectantly. Complete data were available on 158 cases. In total 84.8% (134/158) were managed successfully whilst 15.2% (24/158) failed expectant management. Of the total, 89% (121/136) of women with a PDCS 1 had successful expectant management compared with 57.1 (8/14) with PDCS 2 and 62.5% (5/8) with PDCS 3. Comparing absence of flow (PDCS 1) to presence of flow (PDCS 2 or more), the rate of success was significantly higher in the first group (89 versus 60.9%, Fisher's exact test P= 0.00136). In the prediction of success, the absence of flow

  14. Dosimetric comparison among different head and neck radiotherapy techniques using PRESAGE® dosimeter

    Directory of Open Access Journals (Sweden)

    Jalil Rehman

    2015-12-01

    Full Text Available Purpose: The purpose of this analysis was to investigate dose distribution of Three Dimensional Conformal Radiation Therapy (3DCRT, Intensity Modulated Radiation Therapy (IMRT and Volumetric Modulated Arc Therapy (VMAT for Head and Neck cancer using 3-dimensional PRESAGE® dosimeter. Method: Computer Tomography (CT scans of Radiological Physics Center (RPC Head and Neck anthropomorphic phantom with both RPC standard insert and PRESAGE® insert were acquired separated with Philipp’s CT scanner and both CT scans were exported via DICOM to the pinnacle treatment planning system (TPS. Each plan was delivered twice to the RPC phantom first containing the RPC standard insert having Thermoluminescent detectors (TLD and film dosimeters and then again containing the PRESAGE® insert having three dimensional dosimeter (PRESAGE® by using a Varian True beam linear accelerator. After irradiation, the standard insert including point dose measurement (TLD and planner GafChromic® EBT film measurement was read using RPC standard procedure. The 3D dose distribution from PRESAGE® was read out with the Duke Midsized optical scanner dedicated to RPC (DMOS-RPC. Dose volume histogram (DVH, mean and maximal doses for organ-at-risk (OARs were calculated and compared among each Head and Neck technique. The prescription dose was same for all Head and Neck radiotherapy techniques which was 6.60 Gy per friction. Beam profile comparison and gamma analysis were used to quantify agreement among film measurement, PRESAGE® measurement and calculated dose distribution. Quality assurances of all plans were performed by using ArcCHECK method. Results: VMAT delivered the lowest mean and maximal doses to organ at risk (spinal cord and parotid than IMRT and 3DCRT. Such dose distribution was verified by absolute dose distribution using TLD system. 2D gamma 5%/3 mm criteria of Pinnacle vs. EBT2 film 3DCRT (92.34%, IMRT (92.3% and VMAT (96.63% in axial plan respectively. It was

  15. The Requirements and Design of the Rapid Prototyping Capabilities System

    Science.gov (United States)

    Haupt, T. A.; Moorhead, R.; O'Hara, C.; Anantharaj, V.

    2006-12-01

    The Rapid Prototyping Capabilities (RPC) system will provide the capability to rapidly evaluate innovative methods of linking science observations. To this end, the RPC will provide the capability to integrate the software components and tools needed to evaluate the use of a wide variety of current and future NASA sensors, numerical models, and research results, model outputs, and knowledge, collectively referred to as "resources". It is assumed that the resources are geographically distributed, and thus RPC will provide the support for the location transparency of the resources. The RPC system requires providing support for: (1) discovery, semantic understanding, secure access and transport mechanisms for data products available from the known data provides; (2) data assimilation and geo- processing tools for all data transformations needed to match given data products to the model input requirements; (3) model management including catalogs of models and model metadata, and mechanisms for creation environments for model execution; and (4) tools for model output analysis and model benchmarking. The challenge involves developing a cyberinfrastructure for a coordinated aggregate of software, hardware and other technologies, necessary to facilitate RPC experiments, as well as human expertise to provide an integrated, "end-to-end" platform to support the RPC objectives. Such aggregation is to be achieved through a horizontal integration of loosely coupled services. The cyberinfrastructure comprises several software layers. At the bottom, the Grid fabric encompasses network protocols, optical networks, computational resources, storage devices, and sensors. At the top, applications use workload managers to coordinate their access to physical resources. Applications are not tightly bounded to a single physical resource. Instead, they bind dynamically to resources (i.e., they are provisioned) via a common grid infrastructure layer. For the RPC system, the

  16. Characteristics analysis on a superconductor resonance coil WPT system according to cooling vessel materials in different distances

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, In-Sung, E-mail: no21park@hanmail.net; Lee, Yu-Kyeong; Choi, Hyo-Sang, E-mail: hyosang@chosun.ac.kr

    2016-11-15

    Highlights: • WPT using the superconductor coil was needed research for cooling vessel. FRP, bakelite, polystyrene, aluminum, and iron were applied as the cooling vessel material to analyze the WPT distance efficiency. • When the distance between the transmitter and receiver coils was 2000 mm, FRP being used for the cooling vessel made the transmission efficiency higher than any other materials. The efficiency and distance of sending power can be improved in the superconductor coil if the cooling vessel is made with FRP. - Abstract: The interest in wireless power transfer (WPT) that can send power without using wires has been increasing recently. Especially, there is a great interest in the wireless power devices for portable IT devices. The WPT devices that have been developed so far use the magnetic induction method, and they are not active due to their distance problem. A magnetic resonance WPT method was developed and has been actively researched to resolve this problem. A superconductor coil was applied in this study to increase the efficiency of the magnetic resonance WPT. FRP, bakelite, polystyrene, aluminum, and iron were applied as the cooling vessel material to analyze the WPT distance. The distance between the transmitter and receiver coils started from 800 mm and was increased by 200 mm. The reflection coefficient was measured at each distance. As a result, FRP, bakelite, plastic PVC, polystyrene of the reflection coefficient was similar. From among these FRP being used for the cooling vessel made the transmission characteristics higher than any other materials when the distance between the transmitter and receiver coils was 2,000 mm. On the other hand, the reflection coefficient dropped when iron was used. It is estimated based on the experimental results that the wireless power transmission characteristics and distance of sending power can be improved in the superconductor coil if the cooling vessel is made with FRP.

  17. Client/Server distributed processing using SunOS remote procedure protocol

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, K.E.; Gilman, T.L.

    1990-01-01

    Over the last ten years the development of PC's and workstations has changed the way computing is performed. Previously, extensive computations were performed on large high speed mainframe machines with substantial storage capacity. Large capital and operational costs were associated with these machines. The advent of more powerful workstations has brought more computational cycles to the users at lower cost than was achieved with busy timesharing systems. However, many users still can't afford individual special purpose hardware or gigabytes of storage. A successful distributed processing environment must share these resources. Client/Server models have been proposed to address the issues of shared resources. They are not a new idea, but their implementation has been difficult. With the introduction of SUN's public domain Remote Procedure Call (RPC) Protocol and SUN's interface generator, RPCGEN, their implementation has been made easier. SUN has developed a set of C'' callable routines that handle the Client/Server operations. The availability of Network File System (NFS) on the SRL CRAY and the arrival of Wollongong's latest version of NFS has allowed applications and information sharing between computing platforms. This paper reviews the Client/Server model with respect to SUN's RPC implementation. The discussion will focus on the RPC connection between local and remote machines, the RPC Paradigm for making remote procedure calls, and the programming levels of the RPC libraries. The paper will conclude with summaries of two applications developed at SRL using the protocol and their effect on our computing environment. These include the Nuclear Plant Analyzer and an animation of fluids using behavioral simulation of atom-like particles.

  18. Pouch Salvage Surgery for Treatment of Colitis and Familial Adenomatous Polyposis: Report of Five Cases

    Directory of Open Access Journals (Sweden)

    Derakhshani

    2016-08-01

    Full Text Available Introduction The restorative proctocolectomy (RPC with ileal pouch-anal anastomosis (IPAA is currently the preferred surgical method for most patients with ulcerative colitis and familial adenomatous polyposis and sometimes, functional bowel diseases. Infection around the pouch, remaining rectal stump, stricture at anastomosis site, pouch dysfunction and refractory pouchitis can lead to pouch failure. Pouch salvage surgery could prevent pouch failure in some cases. Case Presentation In this report, five patients were introduced, who underwent pouch salvage surgery after RPC/IPAA surgery failure. Two of the patients were male and three were female and the relevant age range was 16 to 41. Initially, RPC/IPAA surgery was performed on these five patients. Four of the patients underwent RPC/IPAA surgery as a result of ulcerative colitis and, one of the patients as a result of familial adenomatous polyposis. However, due to pouch failure from the RPC/IPAA surgery, pouch-salvage surgery was performed on each of these five patients. Two of the patients underwent pouch-salvage surgery due to infection and pouch fistula, and the other three underwent this surgery due to the remaining rectal stump, anastomosis stenosis and pouch dysfunction. The average time for when pouch-salvage surgery was performed was 3.5 years (three months to five years after the initial operation and the patients were under follow-up care for two to seven years. Conclusions After performing pouch salvage operation, pouch function was acceptable in all patients and we could close ileostomies of all of them.

  19. Effect of In-Situ Curing on Compressive Strength of Reactive Powder Concrete

    Directory of Open Access Journals (Sweden)

    Bali Ika

    2016-01-01

    Full Text Available A development of Reactive Powder Concrete (RPC currently is the use of quartz powder as a stabilizing agent with the content to cement ratio of 30% and steam curing method in an autoclave temperature of 250ºC which produced a high compressive strength of 180 MPa. That RPC can be generated due to one reason for using the technique of steam curing in an autoclave in the laboratory. This study proposes in-situ curing method in order the curing can be applied in the field and with a reasonable compressive strength results of RPC. As the benchmarks in this study are the curing methods in laboratory that are steam curing of 90°C for 8 hours (C1, and water curing for 28 days (C2. For the in-situ curing methods that are covering with tarpaulins and flowed steam of 3 hours per day for 7 days (C3, covering with wet sacks for 28 days (C4, and covering with wet sacks for 28 days for specimen with unwashed sand as fine aggregate (C5. The comparison of compressive strength of the specimens in this study showed compressive strength of RPC with in-situ steam curing (101.64 MPa close to the compressive strength of RPC with steam curing in the laboratory with 8.2% of different. While in-situ wet curing compared with the water curing in laboratory has the different of 3.4%. These results indicated that the proposed in-situ curing methods are reasonable good in term of the compressive strength that can be achieved.

  20. La revista de psicología contemporánea : análisis y perspectivas

    Directory of Open Access Journals (Sweden)

    Luis Armando Oblitas Guadalupe

    2013-09-01

    Full Text Available La Revista de Psicología Contemporánea (RPC, publicación periódica de la Editorial El Manual Moderno (MM, cumple su primer lustro de existencia. En el presente trabajo se hace una descripción de algunas experiencias significativas tenidas a lo largo de los cinco primeros años de la RPC, en relación a la comunicación establecida entre el autor y MM, comunicación con los colaboradores, suscripciones, promoción, participación en foros, etcétera. También se realiza un análisis de los trabajos publicados hasta el momento en la RPC, así como las tendencias futuras de la revista. La lectura del texto resultará de interés para los psicólogos que desarrollan actividades editoriales o que piensan iniciar la edición de una revista de psicología. The Journal of Contemporary Psychology (Revista de Psicología Contemporánea RPC a periodic publication of the Editorial el Manual Moderno (MM is celebrating its 5th birthday. In the present study a description of some significant experiences along the first five years of RPC are described, focused on the communication between the author and MM, among the collaborators, subscriptions, promotions and forum participation, among others. An analyses of the published articles is also presented as well as the tendencies for the future. The present article will be of interest for psychologists that develop editorial activities or that are going to begin the edition of a journal of psychology.

  1. Ionising sources in the coma of 67P probed by Rosetta

    Science.gov (United States)

    Heritier, Kevin; Galand, Marina; Henri, Pierre; Eriksson, Anders; Odelstad, Elias; Altwegg, Kathrin; Beth, Arnaud; Broiles, Thomas; Burch, Jim; Carr, Christopher; Cupido, Emanuele; Glassmeier, Karl-Heinz; Nilsson, Hans; Richter, Ingo; Rubin, Martin; Vallieres, Xavier; Vigren, Erik

    2017-04-01

    An ionospheric model has been developed in order to quantify the ion number density in the coma of 67P/Churyumov-Gerasimenko. The model is driven by Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA)/Cometary Pressure Sensor (COPS) neutral density and assumes isentropic expansion for the neutral density profile. The two ionisation sources considered are photo-ionisation by solar extreme ultraviolet (EUV) radiation and electron-impact ionisation. The EUV radiation is estimated from fluxes measured by the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED)/ Solar EUV Experiment (SEE), taking into account the phase shift and the heliocentric distance ratio; between Earth and comet 67P. The electron-impact ionisation production rates are derived from Rosetta Plasma Consortium (RPC)-Ion and Electron Sensor (IES) integrated electron fluxes and corrected for the S/C potential from RPC/LAngmuir Probe (LAP) measurements. Our results are compared with in situ measurements of the plasma density from RPC-Mutual Impedance Probe (MIP) and RPC-LAP. There is a good agreement between the modelled and RPC observed electron densities. The ionospheric model enables to distinguish the relative contributions of the different sources to the total cometary plasma. At high heliocentric distances, electron-impact ionisation becomes the dominant ionisation source and is enhanced over the winter hemisphere. As the solar activity has decreased since the beginning of the mission in 2014, the relative importance of photo-ionisation has decreased as well. However, at low heliocentric distances, photo-ionisation seems to be the most dominant ionising source, in particular through the perihelion period in summer 2015.

  2. Phycourobilin in Trichromatic Phycocyanin from Oceanic Cyanobacteria Is Formed Post-translationally by a Phycoerythrobilin Lyase-Isomerase*S⃞

    Science.gov (United States)

    Blot, Nicolas; Wu, Xian-Jun; Thomas, Jean-Claude; Zhang, Juan; Garczarek, Laurence; Böhm, Stephan; Tu, Jun-Ming; Zhou, Ming; Plöscher, Matthias; Eichacker, Lutz; Partensky, Frédéric; Scheer, Hugo; Zhao, Kai-Hong

    2009-01-01

    Most cyanobacteria harvest light with large antenna complexes called phycobilisomes. The diversity of their constituting phycobiliproteins contributes to optimize the photosynthetic capacity of these microorganisms. Phycobiliprotein biosynthesis, which involves several post-translational modifications including covalent attachment of the linear tetrapyrrole chromophores (phycobilins) to apoproteins, begins to be well understood. However, the biosynthetic pathway to the blue-green-absorbing phycourobilin (λmax ∼ 495 nm) remained unknown, although it is the major phycobilin of cyanobacteria living in oceanic areas where blue light penetrates deeply into the water column. We describe a unique trichromatic phycocyanin, R-PC V, extracted from phycobilisomes of Synechococcus sp. strain WH8102. It is evolutionarily remarkable as the only chromoprotein known so far that absorbs the whole wavelength range between 450 and 650 nm. R-PC V carries a phycourobilin chromophore on its α-subunit, and this can be considered an extreme case of adaptation to blue-green light. We also discovered the enzyme, RpcG, responsible for its biosynthesis. This monomeric enzyme catalyzes binding of the green-absorbing phycoerythrobilin at cysteine 84 with concomitant isomerization to phycourobilin. This reaction is analogous to formation of the orange-absorbing phycoviolobilin from the red-absorbing phycocyanobilin that is catalyzed by the lyase-isomerase PecE/F in some freshwater cyanobacteria. The fusion protein, RpcG, and the heterodimeric PecE/F are mutually interchangeable in a heterologous expression system in Escherichia coli. The novel R-PC V likely optimizes rod-core energy transfer in phycobilisomes and thereby adaptation of a major phytoplankton group to the blue-green light prevailing in oceanic waters. PMID:19182270

  3. Shaping Ability of Reciproc, WaveOne GOLD, and HyFlex EDM Single-file Systems in Simulated S-shaped Canals.

    Science.gov (United States)

    Özyürek, Taha; Yılmaz, Koray; Uslu, Gülşah

    2017-05-01

    The aim of the present study was to compare the shaping ability of Reciproc (RPC; VDW, Munich, Germany), HyFlex EDM (HEDM; Coltene/Whaledent AG, Altstätten, Switzerland), and WaveOne GOLD (WOG; Dentsply Maillefer, Ballaigues, Switzerland) nickel-titanium (NiTi) files made of different NiTi alloys in S-shaped simulated canals. Sixty S-shaped canals in resin blocks were prepared to an apical size of 0.25 mm using RPC R25, WOG Primary, and HEDM OneFile (n = 20 canal/per group) systems. Composite images were made from the superimposition of pre- and postinstrumentation images. The amount of resin removed by each system was measured using a digital template and image analysis software in 22 different points. Canal aberrations were also recorded. Data were statistically analyzed using the Kruskal-Wallis and post hoc Dunn tests at the 5% level. NiTi file fracture was not observed during shaping of the simulated canals although a danger zone formation in 1 sample and a ledge in 1 sample were observed in the RPC group. There was no statistically significant difference between the WOG and HEDM groups' apical, medial, and coronal regions (P > .05). However, it was determined that the RPC group removed a statistically significantly higher amount of resin from all the canal regions when compared with the WOG and HEDM groups (P < .05). Within the limitation of the present study, it was determined that all of the tested NiTi files caused various levels of resin removal. However, WOG and HEDM NiTi files were found to cause a lower level of resin removal than RPC NiTi files. Copyright © 2017 American Association of Endodontists. All rights reserved.

  4. Combined effects of potassium chloride and ethanol as mobile phase modulators on hydrophobic interaction and reversed-phase chromatography of three insulin variants.

    Science.gov (United States)

    Johansson, Karolina; Frederiksen, Søren S; Degerman, Marcus; Breil, Martin P; Mollerup, Jørgen M; Nilsson, Bernt

    2015-02-13

    The two main chromatographic modes based on hydrophobicity, hydrophobic interaction chromatography (HIC) and reversed-phase chromatography (RPC), are widely used for both analytical and preparative chromatography of proteins in the pharmaceutical industry. Despite the extensive application of these separation methods, and the vast amount of studies performed on HIC and RPC over the decades, the underlying phenomena remain elusive. As part of a systematic study of the influence of mobile phase modulators in hydrophobicity-based chromatography, we have investigated the effects of both KCl and ethanol on the retention of three insulin variants on two HIC adsorbents and two RPC adsorbents. The focus was on the linear adsorption range, separating the modulator effects from the capacity effects, but some complementary experiments at higher load were included to further investigate observed phenomena. The results show that the modulators have the same effect on the two RPC adsorbents in the linear range, indicating that the modulator concentration only affects the activity of the solute in the mobile phase, and not that of the solute-ligand complex, or that of the ligand. Unfortunately, the HIC adsorbents did not show the same behavior. However, the insulin variants displayed a strong tendency toward self-association on both HIC adsorbents; on one in particular. Since this causes peak fronting, the retention is affected, and this could probably explain the lack of congruity. This conclusion was supported by the results from the non-linear range experiments which were indicative of double-layer adsorption on the HIC adsorbents, while the RPC adsorbents gave the anticipated increased tailing at higher load. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Shape rheocasting of high purity aluminium

    CSIR Research Space (South Africa)

    Curle, UA

    2011-03-01

    Full Text Available ) The HPDC component was a plate of dimensions 100 x 55 x 6 mm excluding the biscuit and the runner. The top-end of the plate was sectioned in the transverse orientation, mounted in bakelite hot mounting resin and finally mechanical polished with colloidal...?Pro MC v6.0 imaging software was used to record the microstructure. The whole HPDC casting (including the plate, runner and biscuit) that was produced for this temperature curve is shown in Figure 2. The surface of the plate is somewhat rough...

  6. Design and Fabrication of Graphene Reinforced Polymer Conductive Patch-Based Inset Fed Microstrip Antenna

    Science.gov (United States)

    Deepak, A.; Kannan, P. Muthu; Shankar, P.

    This work explores the design and fabrication of graphene reinforced polyvinylidene fluoride (PVDF) patch-based microstrip antenna. Primarily, antenna was designed at 6GHz frequency and simulation results were obtained using Ansoft HFSS tool. Later fabrication of antenna was carried out with graphene-PVDF films as conducting patch deposited on bakelite substrate and copper as ground plane. Graphene-PVDF films were prepared using solvent casting process. The radiation efficiency of fabricated microstrip patch antenna was 48% entailing it to be adapted as a practically functional antenna. Both simulated and the practical results were compared and analyzed.

  7. The Steerable Microcatheter: A New Device for Selective Catheterisation

    Energy Technology Data Exchange (ETDEWEB)

    Soyama, Takeshi [Hokkaido University Hospital, Department of Diagnostic and Interventional Radiology (Japan); Yoshida, Daisuke [Sapporo Yamanoue Hospital, Department of Radiology (Japan); Sakuhara, Yusuke, E-mail: yusaku@med.hokudai.ac.jp; Morita, Ryo; Abo, Daisuke; Kudo, Kohsuke [Hokkaido University Hospital, Department of Diagnostic and Interventional Radiology (Japan)

    2017-06-15

    The steerable microcatheter (SwiftNINJA, Sumitomo Bakelite, Tokyo, Japan), which has a remote-controlled flexible tip manipulated using a dial in the handgrip, was recently developed and delivered to the market. This device enables the user to change the angle of the microcatheter tip manually, and potentially makes selective catheterisation easier. We evaluated its unique characteristics and utility in selective catheterisation and coil embolization. This article describes: (1) the advantages of this device in catheterisations involving acute angle branches, and (2) a new technique of compact coil packing with the use of intentional folding by the bendable tip of the catheter.

  8. Determination of scatter fractions of some materials by experimental studies and Monte Carlo calculations

    CERN Document Server

    Meric, N; Bor, D

    1999-01-01

    Scatter fractions have been determined experimentally for lucite, polyethylene, polypropylene, aluminium and copper of varying thicknesses using a polyenergetic broad X-ray beam of 67 kVp. Simulation of the experiment has been carried out by the Monte Carlo technique under the same input conditions. Comparison of the measured and predicted data with each other and with the previously reported values has been given. The Monte Carlo calculations have also been carried out for water, bakelite and bone to examine the dependence of scatter fraction on the density of the scatterer.

  9. DEVELOPMENT AND MANUFACTURE OF COST EFFECTIVE COMPOSITE DRILL PIPE

    Energy Technology Data Exchange (ETDEWEB)

    James C. Leslie; James C. Leslie II; Lee Truong; James T. Heard; Peter Manekas

    2005-03-18

    This technical report presents the engineering research, process development and data accomplishments that have transpired to date in support of the development of Cost Effective Composite Drill Pipe (CDP). The report presents progress made from October 1, 2003 through September 30, 2004 and contains the following discussions: (1) Direct Electrical Connection for Rotary Shoulder Tool Joints; (2) Conductors for inclusion in the pipe wall (ER/DW-CDP); (3) Qualify fibers from Zoltek; (4) Qualify resin from Bakelite; (5) First commercial order for SR-CDP from Integrated Directional Resources (SR-CDP); and (6) Preparation of papers for publication and conference presentations.

  10. Effects of rumen-protected choline and dry propylene glycol on feed intake and blood parameters for Holstein dairy cows in early lactation.

    Science.gov (United States)

    Chung, Y-H; Brown, N E; Martinez, C M; Cassidy, T W; Varga, G A

    2009-06-01

    A 6 x 6 Latin square design was used to test 3 sets of comparisons simultaneously to study response in dry matter intake, milk yield, and blood parameters to propylene glycol (PG) supplementation delivered by 2 methods [incorporating PG into the total mixed ration (TMR) vs. top dressing; comparison I]; individual or combined dietary choline and PG supplementation as a 2 x 2 factorial (comparison II); or increasing amounts of dietary choline (comparison III). Six multiparous (lactation number = 1.5 +/- 0.8 SD) Holstein dairy cows were at 41 d in milk (+/- 9 SD) at the start of the experiment. Propylene glycol used was a dry product containing 65% PG, and choline was a rumen-protected choline product (RPC; estimated to be 50% rumen-protected) containing 50% choline chloride. In comparison I, treatments compared were 1) control: no PG; 2) PG-TMR: 250 g/d of dry PG (corresponding to 162.5 g/d of PG) incorporated into the TMR; and 3) PG-top dress: 250 g/d of dry PG top-dressed onto the TMR. In comparison II, treatments compared were 1) control: no PG and no RPC; 2) PG: 250 g/d of dry PG incorporated into the TMR; 3) RPC: 50 g/d of RPC top-dressed onto the TMR; and 4) PG+RPC: combination of treatments 2 and 3. In comparison III, treatments compared were 0, 25, and 50 g/d of RPC top-dressed onto the TMR. Each experimental period lasted 10 d with 9 d of adaptation followed by 1 d of serial blood sampling. Dry matter intake and milk yield were recorded daily. During the serial blood sampling, jugular blood was sampled every 20 min for the first 4 h and at 8 and 12 h after treatment administration. Results obtained from comparison I showed that feeding 250 g/d of PG as a dry product decreased plasma beta-hydroxybutyrate (BHBA) concentration (mean +/- SEM) from 701 +/- 81 (control) to 564 +/- 76 micromol/L without affecting serum insulin, plasma glucose, or plasma nonesterified fatty acid concentrations. Top-dressing PG decreased plasma BHBA concentrations more than by

  11. Punching Shear Behavior of Continuous Bubbled Reinforced Reactive Powder Concrete Slab

    Directory of Open Access Journals (Sweden)

    Mohammad Redha K. Mahmood

    2017-03-01

    Full Text Available This paper presents an experimental investigation on punching shear behavior of continuous bubbled reinforced Reactive Powder Concrete (RPC slabs. Bubbled slab is one of the various types of voided slabs. It consists of bubbles placed inside a concrete slab which will reduce the self-weight of the structure by about 35% (Tina Lai 2009. On the other hand, using RPC make it possible for structural member to have smaller dimensions due to the great strength of this type of concrete. In this study, these two method to increase the building spaces dimensions by reducing self-weigh of the structure by using bubbled slabs and to decrease the structural members' dimensions by using RPC have been investigated together. To study the punching shear behavior of continuous bubbled flat slabs such as the ultimate load carrying capacity, central deflection and slabs crack pattern at the ultimate load, nine different types of slabs were tested. The parameters of the study were type of concrete (RPC and Normal Concrete (NC, bubbles diameter to slab thickness ratio (D/t of (0.6 and 0.7, bubbles location (at all slab area, started from distance D and 1.5D from the center slab and solid slab. The test results show that the crack pattern and ultimate load capacity as well as maximum deflection depends on all of the mentioned parameters, were by increasing (D/t ratio the ultimate load capacity increases about (6.49 and 9.58% for slabs with bubbles started at distance 2D and 3D, respectively. But in the slabs with bubbles at all slab area the ultimate load and the maximum deflection decreases about (6.63 and 9.47% and (7.96 and 6.84% for RPC and NC slabs, respectively. Also, the solid slab increases the ultimate load about (5.28% compare to bubbled slab at all area. It was found that by removing bubbles from center of the slab at distance 2D and 3D the ultimate load will increase about (14.72 and 8.76%, respectively for slabs with (D/t = 0.6 compare to slabs with

  12. The physics of Resistive Plate Chambers

    CERN Document Server

    Riegler, Werner

    2004-01-01

    Over the last 3 years we investigated theoretical aspects of Resistive Plate Chambers (RPC) in order to clarify some of the outstanding questions on space charge effects, high efficiency of small gap RPCs, charge spectra, signal shape and time resolution. In a series of reports we analyzed RPC performance including all detector aspects covering primary ionization, avalanche multiplication, space charge effects, signal induction in presence of resistive materials, crosstalk along detectors with long strips and front-end electronics. Using detector gas parameters entirely based on theoretical predictions and physical models for avalanche development and space charge effects we are able to reproduce measurements for 2 and 0.3 mm RPCs to very high accuracy without any additional assumptions. This fact gives a profound insight into the workings of RPCs and also underlines the striking difference in operation regime when compared to wire chambers. A summary of this work as well as recent results on three-dimensiona...

  13. A study of materials used for muon chambers at the CMS Experiment at the LHC: interaction with gas, new materials and new technologies for detector upgrade

    CERN Document Server

    Colafranceschi, Stefano

    This thesis lays its foundation in both technological and theoretical stud- ies carried out between several aspects of applied engineering. There are several original contributions within the material science. The first is the detailed studies about the CMS RPC gas filters, which required an intense 3 years data-taking and ended up with a complete characterization of purifier materials. On top of this a stable ad − hoc setup (GGM) has been devel- oped for the CMS Experiment in order to monitor the RPC muon chamber working point. Finally a complete new detector has been designed, build and tested using new technology and new electronics establishing the word’s record in size for this kind of detector, which is taken under consideration for the upgrade of the high-η region of the CMS Experiment.

  14. Muon Detection Based on a Hadronic Calorimeter

    CERN Document Server

    Ciodaro, Thiago; Abreu, R; Achenbach, R; Adragna, P; Aharrouche, M; Aielli, G; Al-Shabibi, A; Aleksandrov, I; Alexandrov, E; Aloisio, A; Alviggi, M G; Amorim, A; Amram, N; Andrei, V; Anduaga, X; Angelaszek, D; Anjos, N; Annovi, A; Antonelli, S; Anulli, F; Apolle, R; Aracena, I; Ask, S; Åsman, B; Avolio, G; Baak, M; Backes, M; Backlund, S; Badescu, E; Baines, J; Ballestrero, S; Banerjee, S; Bansil, H S; Barnett, B M; Bartoldus, R; Bartsch, V; Batraneanu, S; Battaglia, A; Bauss, B; Beauchemin, P; Beck, H P; Bee, C; Begel, M; Behera, P K; Bell, P; Bell, W H; Bellagamba, L; Bellomo, M; Ben Ami, S; Bendel, M; Benhammou, Y; Benslama, K; Berge, D; Bernius, C; Berry, T; Bianco, M; Biglietti, M; Blair, R E; Bogaerts, A; Bohm, C; Boisvert, V; Bold, T; Bondioli, M; Borer, C; Boscherini, D; Bosman, M; Bossini, E; Boveia, A; Bracinik, J; Brandt, A G; Brawn, I P; Brelier, B; Brenner, R; Bressler, S; Brock, R; Brooks, W K; Brown, G; Brunet, S; Bruni, A; Bruni, G; Bucci, F; Buda, S; Burckhart-Chromek, D; Buscher, V; Buttinger, W; Calvet, S; Camarri, P; Campanelli, M; Canale, V; Canelli, F; Capasso, L; Caprini, M; Caracinha, D; Caramarcu, C; Cardarelli, R; Carlino, G; Casadei, D; Casado, M P; Cattani, G; Cerri, A; Cerrito, L; Chapleau, B; Childers, J T; Chiodini, G; Christidi, I; Ciapetti, G; Cimino, D; Ciobotaru, M; Coccaro, A; Cogan, J; Collins, N J; Conde Muino, P; Conidi, C; Conventi, F; Corradi, M; Corso-Radu, A; Coura Torres, R; Cranmer, K; Crescioli, F; Crone, G; Crupi, R; Cuenca Almenar, C; Cummings, J T; Curtis, C J; Czyczula, Z; Dam, M; Damazio, D; Dao, V; Darlea, G L; Davis, A O; De Asmundis, R; De Pedis, D; De Santo, A; de Seixas, J M; Degenhardt, J; Della Pietra, M; Della Volpe, D; Demers, S; Demirkoz, B; Di Ciaccio, A; Di Mattia, A; Di Nardo, R; Di Simone, A; Diaz, M A; Dietzsch, T A; Dionisi, C; Dobson, E; Dobson, M; dos Anjos, A; Dotti, A; Dova, M T; Drake, G; Dufour, M-A; Dumitru, I; Eckweiler, S; Ehrenfeld, W; Eifert, T; Eisenhandler, E; Ellis, K V; Ellis, N; Emeliyanov, D; Enoque Ferreira de Lima, D; Ermoline, Y; Ernst, J; Etzion, E; Falciano, S; Farrington, S; Farthouat, P; Faulkner, P J W; Fedorko, W; Fellmann, D; Feng, E; Ferrag, S; Ferrari, R; Ferrer, M L; Fiorini, L; Fischer, G; Flowerdew, M J; Fonseca Martin, T; Francis, D; Fratina, S; French, S T; Front, D; Fukunaga, C; Gadomski, S; Garelli, N; Garitaonandia Elejabarrieta, H; Gaudio, G; Gee, C N P; George, S; Giagu, S; Giannetti, P; Gillman, A R; Giorgi, M; Giunta, M; Giusti, P; Goebel, M; Gonçalo, R; Gonzalez Silva, L; Göringer, C; Gorini, B; Gorini, E; Grabowska-Bold, I; Green, B; Groll, M; Guida, A; Guler, H; Haas, S; Hadavand, H; Hadley, D R; Haller, J; Hamilton, A; Hanke, P; Hansen, J R; Hasegawa, S; Hasegawa, Y; Hauser, R; Hayakawa, T; Hayden, D; Head, S; Heim, S; Hellman, S; Henke, M; Hershenhorn, A; Hidvégi, A; Hillert, S; Hillier, S J; Hirayama, S; Hod, N; Hoffmann, D; Hong, T M; Hryn'ova, T; Huston, J; Iacobucci, G; Igonkina, O; Ikeno, M; Ilchenko, Y; Ishikawa, A; Ishino, M; Iwasaki, H; Izzo, V; Jez, P; Jimenez Otero, S; Johansen, M; Johns, K; Jones, G; Joos, M; Kadlecik, P; Kajomovitz, E; Kanaya, N; Kanega, F; Kanno, T; Kapliy, A; Kaushik, V; Kawagoe, K; Kawamoto, T; Kazarov, A; Kehoe, R; Kessoku, K; Khomich, A; Khoriauli, G; Kieft, G; Kirk, J; Klemetti, M; Klofver, P; Klous, S; Kluge, E-E; Kobayashi, T; Koeneke, K; Koletsou, I; Koll, J D; Kolos, S; Kono, T; Konoplich, R; Konstantinidis, N; Korcyl, K; Kordas, K; Kotov, V; Kowalewski, R V; Krasznahorkay, A; Kraus, J; Kreisel, A; Kubota, T; Kugel, A; Kunkle, J; Kurashige, H; Kuze, M; Kwee, R; Laforge, B; Landon, M; Lane, J; Lankford, A J; Laranjeira Lima, S M; Larner, A; Leahu, L; Lehmann Miotto, G; Lei, X; Lellouch, D; Levinson, L; Li, S; Liberti, B; Lilley, J N; Linnemann, J T; Lipeles, E; Lohse, T; Losada, M; Lowe, A; Luci, C; Luminari, L; Lundberg, J; Lupu, N; Machado Miguéns, J; Mackeprang, R; Maettig, S; Magnoni, L; Maiani, C; Maltrana, D; Mangeard, P-S; Männer, R; Mapelli, L; Marchese, F; Marino, C; Martin, B; Martin, B T; Martin, T; Martyniuk, A; Marzano, F; Masik, J; Mastrandrea, P; Matsushita, T; McCarn, A; Mechnich, J; Medinnis, M; Meier, K; Melachrinos, C; Mendoza Nava, L M; Merola, L; Messina, A; Meyer, C P; Middleton, R P; Mikenberg, G; Mills, C M; Mincer, A; Mineev, M; Misiejuk, A; Moa, T; Moenig, K; Monk, J; Monticelli, F; Mora Herrera, C; Morettini, P; Morris, J D; Müller, F; Munwes, Y; Murillo Garcia, R; Nagano, K; Nagasaka, Y; Navarro, G A; Negri, A; Nelson, S; Nemethy, P; Neubauer, M S; Neusiedl, A; Newman, P; Nisati, A; Nomoto, H; Nozaki, M; Nozicka, M; Nurse, E; Ochando, C; Ochi, A; Oda, S; Oh, A; Ohm, C; Okumura, Y; Olivito, D; Omachi, C; Osculati, B; Oshita, H; Ospanov, R; Owen, M A; Özcan, V E; Ozone, K; Padilla, C; Panes, B; Panikashvili, N; Paramonov, A; Parodi, F; Pasqualucci, E; Pastore, F; Patricelli, S; Pauly, T; Perera, V J O; Perez, E; Petcu, M; Petersen, B A; Petersen, J; Petrolo, E; Phan, A; Piegaia, R; Pilkington, A; Pinder, A; Poddar, S; Polini, A; Pope, B G; Potter, C T; Primavera, M; Prokoshin, F; Ptacek, E; Qian, W; Quinonez, F; Rajagopalan, S; Ramos Dos Santos Neves, R; Reinherz-Aronis, E; Reinsch, A; Renkel, P; Rescigno, M; Rieke, S; Riu, I; Robertson, S H; Robinson, M; Rodriguez, D; Roich, A; Romeo, G; Romero, R; Roos, L; Ruiz Martinez, A; Ryabov, Y; Ryan, P; Saavedra, A; Safai Tehrani, F; Sakamoto, H; Salamanna, G; Salamon, A; Saland, J; Salnikov, A; Salvatore, F; Sankey, D P C; Santamarina, C; Santonico, R; Sarkisyan-Grinbaum, E; Sasaki, O; Savu, D; Scannicchio, D A; Schäfer, U; Scharf, V L; Scheirich, D; Schiavi, C; Schlereth, J; Schmitt, K; Schroder, C; Schroer, N; Schultz-Coulon, H-C; Schwienhorst, R; Sekhniaidze, G; Sfyrla, A; Shamim, M; Sherman, D; Shimojima, M; Shochet, M; Shooltz, D; Sidoti, A; Silbert, O; Silverstein, S; Sinev, N; Siragusa, G; Sivoklokov, S; Sjoen, R; Sjölin, J; Slagle, K; Sloper, J E; Smith, B C; Soffer, A; Soloviev, I; Spagnolo, S; Spiwoks, R; Staley, R J; Stamen, R; Stancu, S; Steinberg, P; Stelzer, J; Stockton, M C; Straessner, A; Strauss, E A; Strom, D; Su, D; Sugaya, Y; Sugimoto, T; Sushkov, S; Sutton, M R; Suzuki, Y; Taffard, A; Taiblum, N; Takahashi, Y; Takeda, H; Takeshita, T; Tamsett, M; Tan, C L A; Tanaka, S; Tapprogge, S; Tarem, S; Tarem, Z; Taylor, C; Teixeira-Dias, P; Thomas, J P; Thompson, P D; Thomson, M A; Tokushuku, K; Tollefson, K; Tomoto, M; Topfel, C; Torrence, E; Touchard, F; Traynor, D; Tremblet, L; Tricoli, A; Tripiana, M; Triplett, N; True, P; Tsiakiris, M; Tsuno, S; Tuggle, J; Ünel, G; Urquijo, P; Urrejola, P; Usai, G; Vachon, B; Vallecorsa, S; Valsan, L; Vandelli, W; Vari, R; Vaz Gil Lopes, L; Veneziano, S; Ventura, A; Venturi, N; Vercesi, V; Vermeulen, J C; Volpi, G; Vorwerk, V; Wagner, P; Wang, M; Warburton, A; Watkins, P M; Watson, A T; Watson, M; Weber, P; Weidberg, A R; Wengler, T; Werner, P; Werth, M; Wessels, M; White, M; Whiteson, D; Wickens, F J; Wiedenmann, W; Wielers, M; Winklmeier, F; Woods, K S; Wu, S-L; Wu, X; Xaplanteris Karampatsos, L; Xella, S; Yakovlev, A; Yamazaki, Y; Yang, U; Yasu, Y; Yuan, L; Zaitsev, A; Zanello, L; Zhang, H; Zhang, J; Zhao, L; Zobernig, H; zur Nedden, M

    2010-01-01

    The TileCal hadronic calorimeter provides a muon signal which can be used to assist in muon tagging at the ATLAS level-one trigger. Originally, the muon signal was conceived to be combined with the RPC trigger in order to reduce unforeseen high trigger rates due to cavern background. Nevertheless, the combined trigger cannot significantly deteriorate the muon detection performance at the barrel region. This paper presents preliminary studies concerning the impact in muon identification at the ATLAS level-one trigger, through the use of Monte Carlo simulations with single muons with 40 GeV/c momentum. Further, different trigger scenarios were proposed, together with an approach for matching both TileCal and RPC geometries.

  15. The MONOLITH prototype

    CERN Document Server

    Ambrosio, M; Bencivenni, G; Candela, A M; Chiarini, A; Chignoli, F; De Deo, M; D'Incecco, M; Gerli, S; Giusti, P; Gómez, F; Gustavino, C; Lindozzi, M; Mannocchi, G; Menghetti, H; Morello, C; Murtas, F; Paoluzzi, G; Pilastrini, R; Redaelli, N G; Santoni, M; Sartorelli, G; Terranova, F; Trinchero, G C

    2000-01-01

    MONOLITH (Massive Observatory for Neutrino Oscillation or LImits on THeir existence) is the project of an experiment to study atmospheric neutrino oscillations with a massive magnetized iron detector. The baseline option is a 34 kt iron detector based on the use of about 50000 m/sup 2/ of the glass Resistive Plate Chambers (glass RPCs) developed at the Laboratori Nazionali del Gran Sasso (LNGS). An 8 ton prototype equipped with 23 m/sup 2/ of glass RPC has been realized and tested at the T7-PS beam at CERN. The energy resolution for pions follows a 68%/ square root (E(GeV))+2% law for orthogonally incident particles, in the energy range between 2 and 10 GeV. The time resolution and the tracking capability of the glass RPC are suitable for the MONOLITH experiment. (7 refs).

  16. The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide

    DEFF Research Database (Denmark)

    Cassoli, Juliana Silva; Verano-Braga, Thiago; Oliveira, Joacir Stolarz

    2013-01-01

    duerdeni from Brazilian coast. We used a combination of offline RPC-MALDI-TOF and online nano-RPC-ESI-LTQ-Orbitrap proteomic techniques as well as functional bioassays. The mucus was milked by electric stimulation and fractionated by gel filtration on Sephadex G-50 yielding 5 main fractions. The low......, a new peptide of 3431Da, named U-SHTX-Sdd1, was purified and completely sequenced by automated Edman's degradation and tandem mass spectrometry. An analysis of U-SHTX-Sdd1 revealed a modified O-HexNAc-Threonine at position 1, which, at the best of our knowledge, constitutes the first sea anemone toxin...... present in sea anemone secretions, the number of reported primary sequences is still low. Thus, to access the scenery of protein components from S. duerdeni mucus, including their biological functions, a robust proteomic approach was used together with bioinformatic tools. The demonstrated strategy...

  17. Avaliação da relação proteína-creatinina urinária em gatos com doença renal crônica

    Directory of Open Access Journals (Sweden)

    Maria Cristina N. Castro

    2009-08-01

    Full Text Available Doença renal crônica (DRC é a forma mais comum de doença renal em gatos. Vários fatores têm sido citados como importantes na progressão da doença, dentre eles a proteinúria. A relação proteína-creatinina (RPC urinária em uma única amostra de urina apresenta boa correlação com a perda de proteína urinária em 24 horas. O objetivo dessa investigação foi determinar a RPC urinária em gatos com DRC adquirida naturalmente. A determinação da RPC foi realizada em nove gatos saudáveis (Grupo I e em trinta gatos com DRC (Grupo II. Os gatos do Grupo I apresentaram RPC de 0,16±0,10 e os gatos do Grupo II apresentaram RPC de 0,53± 0,59. No Grupo II encontrou-se correlação positiva e significante da RPC com o nível de creatinina sérica. Os resultados deste estudo demonstram que a RPC urinária em gatos com DRC é bastante variável e que, à semelhança do que já havia sido previamente descrito, aproximadamente um terço dos gatos com DRC são considerados proteinúricos segundo critérios estabelecidos pela literatura (RPC urinária >0,4.Chronic renal disease (CRD is the most common form of renal disease in cats. Several factors contribute to disease progression. Proteinuria is an important marker of renal disease progression. The protein-creatinine ratio in a single urine sample correlates well with urinary protein loss in 24 hours. The aim of this investigation was to determine the urine protein-creatinine (UPC ratio in cats with natural acquired chronic renal disease. The UPC ratio was performed in nine clinically normal cats and in 30 cats with chronic renal disease. Mean UPC ratio in normal cats was 0.16±0.10, and mean UPC ratio in the cats with chronic renal disease was 0.53± 0.59. In the group with renal disease there was positive correlation between UPC ratio and serum creatinine levels. The results obtained from this study demonstrate that UPC ratio in cats with CRD is variable and that, in accordance to what has

  18. Gclust Server: 112730 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 112730 Rpa3_RPC_0247 Cluster Sequences Related Sequences(20) 210 40-residue YVTN be...ta-propeller repeat 1 1.00e-99 0.0 0.0 0.0 6.67 0.0 0.0 Show 112730 Cluster ID 112730 Sequence ID Rpa3_RPC_0247 Link to clus...ter sequences Cluster Sequences Link to related sequences Related Sequences(20) Sequence len... Sequences 1 Homologs 1 Clustering threshold 1.00e-99 Plants and algae (7species) (%) 0.0 Other Bikonts (Chr...s and fungi) (8species) (%) 0.0 Number of Sequences for each species Rpa3: 1 Species not appearing in this clus

  19. The model of back-flow mixed tanks-in-series used for representing the liquid flow in a reciprocating plate column

    Directory of Open Access Journals (Sweden)

    Nikolić Ljubiša B.

    2003-01-01

    Full Text Available The influence of different working parameters (vibration intensity superficial gas and liquid rate and content of the solid phase on liquid flow in a multiphase (gas-liquid: RPC-II and gas-liquid-solid: RPC-III reciprocating plate column was analyzed using step-response methods and sorbic acid as a tracer. The liquid flow was determined using a model of N-tanks in series followed by back mixing of the liquid phase between the tanks. The parameters of this model N, a and x were calculated by applying several methods: calculation of the moments of the residence time distribution function for a constant number of tanks in series (N=const analysis of a set of linear equations for N *const and determination of the minimum of defined goal function using the optimization technique leastsq.m of MATLAB software.

  20. On the H8 beam line of the SPS in the North Area, a complete slice of the ATLAS detector is taking shape

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The Inner Detector and Calorimetry setup. The Liquid Argon electromagnetic calorimeter in its cryostat, and the tile calorimeter (centre) are mounted such that they can be repositioned in the beam, which travels from left to right. Also visible is the magnet housing the Pixel and SCT detectors (far left), the Transition Radiation Tracker (left) and part of a MDT/RPC Muon chamber (far right).

  1. The upgraded KLM detector at Belle II

    Science.gov (United States)

    Piilonen, Leo; Belle Collaboration, II

    2016-03-01

    We describe the KLM (KLong-Muon) detector for the Belle II detector at the SuperKEKB accelerator located at KEK in Tsukuba, Japan. The endcap RPC (Resistive Plate Chamber) detectors used for Belle have been entirely replaced with a scintillator-based system readout out with Si PMTs. The inner two layers of the barrel have also been replaced. The readout using ``oscilloscope on a chip''-based readout electronics will be discussed, as well as expected physics performance.

  2. Telemetry Standards, RCC Standard 106-17, Chapter 27, RF Network Access Layer

    Science.gov (United States)

    2017-07-01

    GIF RPC, PAP, SSL, SQL TCP, UDP, NETBEUI 3. Network 2. Data Link 1. Physical Structuring and managing a multi-node network, including addressing...h0000) for transmission; ignored on reception. 27.5.5 Frame Check Sequence Field A 32-bit FCS shall be computed over the entire MAC frame...rate, LDPC codeblock size, LDPC preamble, ASM sizes, and the goal rate for mission data from the program . The light-pink boxes represent calculated

  3. A Validated Stability-Indicating HPLC Method for Routine Analysis of an Injectable Lincomycin and Spectinomycin Formulation

    OpenAIRE

    Abualhasan,Murad; Batrawi, Nidal; SUTCLIFFE, Oliver; ZAID, Abdel

    2012-01-01

    Lincomycin and spectinomycin combination therapy is widely used in veterinary medicine for the treatment of gastrointestinal and respiratory infections caused by lincomycin- and spectinomycin-sensitive microorganisms. A simple, reverse phase HPLC method for the analysis of samples of an injectable lincomycin and spectinomycin preparation containing a mixture of inactive excipients has been developed. The HPLC was carried out using the RP-C18 (250 mm × 4.0 mm, 5 μm) column, with the gradient m...

  4. Bilogy Machine Initiative: Developing Innovative Novel Methods to Improve Neuro-rehabilitation for Amputees and Treatment for Patients at Remote Sites with Acute Brain Injury

    Science.gov (United States)

    2010-09-01

    controlled interfaces (BCIs) and training programs for the next generation of neurally-controlled prostheses . Toward this end, we conducted a series of... hybridization analysis revealed an unexpected change in the transgene expression of the payload line: it simply stopped expressing in certain crosses...Web-services will be provided as a hybrid Representational State Transfer (REST) and Remote Procedure Call (RPC) system. Security and access to the

  5. Dicty_cDB: SLI815 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available g33080) mRNA, complete cds. 54 0.003 1 E24613 |E24613.1 warts Protein, polynucleotide encoding the protein, ...1739, N1743, N1747, N1751, YCK2, N1761, N1765, RPC31, N1773, N1774, N1777, N1780, N1785, N1790 genes. 40 0.001 5 E24614 |E24614.1 war...ts Protein, polynucleotide encoding the protein, antisen

  6. Respuesta modular de los componentes craneanos por acción hormonal en el retardo prenatal de crecimiento

    Directory of Open Access Journals (Sweden)

    Quintero, Fabián

    2007-01-01

    Full Text Available La plasticidad fenotípica es producto de la interacción dinámica entre la información genética y el ambiente, constituyendo el sistema endocrino un intermediario entre ambos. La desnutrición, en el período prenatal y postnatal temprano, puede retrasar el crecimiento. El Catch-up resulta de un período de aceleración del crecimiento que permite a los organismos recuperar su tamaño corporal. Sin embargo, las respuestas son heterogéneas y dependen de condiciones externas y factores intrínsecos vinculados al eje somatotrópico. El presente trabajo analiza el efecto de la hormona de crecimiento (GH sobre las trayectorias de crecimiento de los componentes craneanos neural y facial de animales con retardo prenatal de crecimiento (RPC. Ratas Wistar constituyeron los grupos: Control, RPC y RPC+GH. El RPC se indujo por obstrucción de arterias uterinas. La GH se administró entre 21-60 días de edad. A 1os 1, 21, 42, 63 y 84 días se midieron sobre Rx longitud, ancho y altura del neuro y esplacnocráneo. Se realizó análisis de componentes principales y se calcularon los volúmenes neural y facial ajustados por curvas de regresión. Se concluye que los componentes craneanos facial y neural presentan diferentes estrategias de recuperación en respuesta a la GH, mostrando comportamiento modular.

  7. Making the Most out of Direct-Access Network Attached Storage

    OpenAIRE

    Fedorova, Alexandra; Magoutis, Kostas; Addetia, Salimah; Seltzer, Margo

    2003-01-01

    The performance of high-speed network-attached storage applications is often limited by end-system overhead, caused primarily by memory copying and network protocol processing. In this paper, we examine alternative strategies for reducing overhead in such systems. We consider optimizations to remote procedure call (RPC)-based data transfer using either remote direct memory access (RDMA) or network interface support for pre-posting of application receive buffers. We demonstrate that b...

  8. Neuronmaster: an integrated tool for applications in neural networks

    Science.gov (United States)

    Rivas-Echeverria, Francklin; Colina-Morles, Eliezer; Sole, Solazver; Perez-Mendez, Anna; Bravo-Bravo, Cesar; Bravo-Bravo, Victor

    2001-03-01

    This work presents the design of an integral environment for the suitable development of neural networks applications. The integrated environment contemplates the following features: A data processing module which encompasses statistical data analysis techniques for variables selection reduction, a variety of learning algorithms, code generator for different computer languages to enable network implementation, a learning sessions planning module and database connectivity facilities via ODBC, RPC, and API.

  9. Rating of perceived capacity: a proposal to predict adequate levels of physical activity in visually impaired individuals.

    Science.gov (United States)

    Barbosa, Diego G; Andrade, Rubian D; Pelegrini, Andreia; Felden, Érico P

    2017-11-07

    There are several instruments that are generally used to analyze levels of physical activity (PA) in people with visual impairment. However, few instruments are validated for this population.The purpose of this study was to compare the subjective and objective variables of PA and to propose the use of the Rating of Perceived Capacity (RPC) to evaluate the level of moderate to vigorous physical activity (MVPA) per day in this population. Thirty-seven individuals with visual impairment participated in the study (19 blind without light perception and 18 low-vision). For the subjective physical activity evaluation, it was used the International Physical Activity Questionnaire Short Form (IPAQ-SF) and for the objective evaluation, it was used the ActiGraph GT3X+. Among the three analyzed (PA) intensities: moderate physical activity (MPA), vigorous physical activity (VPA) and MVPA, in VPA and MVPA was observed differences between the two methods (p=0.002 and p=0.011 respectively). Furthermore, the concordance between subjective and objective MVPA was not observed (ICC=0.239; p=0.176), and a greater variability of differences in MVPA between the two methods was observed by the Bland Altman scatter plot. However, positive correlation were found between the RPC and MVPA (p=0.470; p=0.003). In addition, in the Receiver Operating Characteristic (ROC) curve analysis, it was verified that values greater than 8 points in the RPC showed a predictive capacity for sufficient levels of objective MVPA (AUC = 0.809, sensitivity = 66.7, specificity = 90.9, p = visually impaired individuals. On the other hand, RPC presented itself as a alternative, practical and accessible tool to predict adequate levels of MVPA per day in this population.

  10. CERN-MOVIE-2013-113

    CERN Multimedia

    2013-01-01

    The video shows the installation of a muon barrel package (DT+RPC) in the uppermost sector of the central wheel of CMS. It was extracted from its original position and brought to the ground on August 19 2013 in order to fix a high voltage problem in the DT chamber present since 2009. The chamber was reinstalled on August 21st 2013 after performing the reparation and the required quality checks.

  11. Hardware Acceleration for Cyber Security

    Science.gov (United States)

    2010-11-01

    adapters from Napatech [23]. Platforms provided by research comunity are COMBO cards [4] from CESNET and NetFPGA [24] cards from Stanford. Endace and... manager providing user interface on the client (SOC) side and the NETCONF agent applica- tion that controls configuration datastores on the device side. On...using NETCONF protocol. NETCONF uses simple Remote Procedure Call (RPC)-like approach to exchange messages between manager and agent application. This

  12. Visualization of Radial Peripapillary Capillaries Using Optical Coherence Tomography Angiography: The Effect of Image Averaging.

    Directory of Open Access Journals (Sweden)

    Shelley Mo

    Full Text Available To assess the effect of image registration and averaging on the visualization and quantification of the radial peripapillary capillary (RPC network on optical coherence tomography angiography (OCTA.Twenty-two healthy controls were imaged with a commercial OCTA system (AngioVue, Optovue, Inc.. Ten 10x10° scans of the optic disc were obtained, and the most superficial layer (50-μm slab extending from the inner limiting membrane was extracted for analysis. Rigid registration was achieved using ImageJ, and averaging of each 2 to 10 frames was performed in five ~2x2° regions of interest (ROI located 1° from the optic disc margin. The ROI were automatically skeletonized. Signal-to-noise ratio (SNR, number of endpoints and mean capillary length from the skeleton, capillary density, and mean intercapillary distance (ICD were measured for the reference and each averaged ROI. Repeated measures analysis of variance was used to assess statistical significance. Three patients with primary open angle glaucoma were also imaged to compare RPC density to controls.Qualitatively, vessels appeared smoother and closer to histologic descriptions with increasing number of averaged frames. Quantitatively, number of endpoints decreased by 51%, and SNR, mean capillary length, capillary density, and ICD increased by 44%, 91%, 11%, and 4.5% from single frame to 10-frame averaged, respectively. The 10-frame averaged images from the glaucomatous eyes revealed decreased density correlating to visual field defects and retinal nerve fiber layer thinning.OCTA image registration and averaging is a viable and accessible method to enhance the visualization of RPCs, with significant improvements in image quality and RPC quantitative parameters. With this technique, we will be able to non-invasively and reliably study RPC involvement in diseases such as glaucoma.

  13. High-speed readout method of ID information on a large amount of electronic tags

    Science.gov (United States)

    Nagate, Wataru; Sasabe, Masahiro; Nakano, Hirotaka

    2006-10-01

    An electronic tag such as RFID is expected to create new services that cannot be achieved by the traditional bar code. Specifically, in a distribution system, simultaneous readout method of a large amount of electronic tags embedded in products is required to reduce costs and time. In this paper, we propose novel methods, called Response Probability Control (RPC), to accomplish this requirement. In RPC, a reader firstly sends an ID request to electronic tags in its access area. It succeeds reading information on a tag only if other tags do not respond. To improve the readout efficiency, the reader appropriately controls the response probability in accordance with the number of tags. However, this approach cannot entirely avoid a collision of multiple responses. When a collision occurs, ID information is lost. To reduce the amount of lost data, we divide the ID registration process into two steps. The reader first gathers the former part of the original ID, called temporal ID, according to the above method. After obtaining the temporal ID, it sequentially collects the latter part of ID, called remaining ID, based on the temporal ID. Note that we determine the number of bits of a temporal ID in accordance with the number of tags in the access area so that each tag can be distinguishable. Through simulation experiments, we evaluate RPC in terms of the readout efficiency. Simulation results show that RPC can accomplish the readout efficiency 1.17 times higher than the traditional method where there are a thousand of electronic tags whose IDs are 128 bits.

  14. Eddy current testing

    Energy Technology Data Exchange (ETDEWEB)

    Song, Sung Jin; Lee, Hyang Beom; Kim, Young Hwan [Soongsil Univ., Seoul (Korea, Republic of); Shin, Young Kil [Kunsan Univ., Gunsan (Korea, Republic of)

    2004-02-15

    Eddy current testing has been widely used for non destructive testing of steam generator tubes. In order to retain reliability in ECT, the following subjects were carried out in this study: numerical modeling and analysis of defects by using BC and RPC probes in SG tube, preparation of absolute coil impedance plane diagram by FEM. Signal interpretation of the eddy current signals obtained from nuclear power plants.

  15. Response of Korean pine's functional traits to geography and climate.

    Directory of Open Access Journals (Sweden)

    Yichen Dong

    Full Text Available This study analyzed the characteristics of Korean pine (Pinus koraiensis functional trait responses to geographic and climatic factors in the eastern region of Northeast China (41°-48°N and the linear relationships among Korean pine functional traits, to explore this species' adaptability and ecological regulation strategies under different environmental conditions. Korean pine samples were collected from eight sites located at different latitudes, and the following factors were determined for each site: geographic factors-latitude, longitude, and altitude; temperature factors-mean annual temperature (MAT, growth season mean temperature (GST, and mean temperature of the coldest month (MTCM; and moisture factors-annual precipitation (AP, growth season precipitation (GSP, and potential evapotranspiration (PET. The Korean pine functional traits examined were specific leaf area (SLA, leaf thickness (LT, leaf dry matter content (LDMC, specific root length (SRL, leaf nitrogen content (LNC, leaf phosphorus content (LPC, root nitrogen content (RNC, and root phosphorus content (RPC. The results showed that Korean pine functional traits were significantly correlated to latitude, altitude, GST, MTCM, AP, GSP, and PET. Among the Korean pine functional traits, SLA showed significant linear relationships with LT, LDMC, LNC, LPC, and RPC, and LT showed significant linear relationships with LDMC, SRL, LNC, LPC, RNC, and RPC; the linear relationships between LNC, LPC, RNC, and RPC were also significant. In conclusion, Korean pine functional trait responses to latitude resulted in its adaptation to geographic and climatic factors. The main limiting factors were precipitation and evapotranspiration, followed by altitude, latitude, GST, and MTCM. The impacts of longitude and MAT were not obvious. Changes in precipitation and temperature were most responsible for the close correlation among Korean pine functional traits, reflecting its adaption to habitat

  16. Transmission Power Determination Based on Power Amplifier Operations in Large-Scale MIMO-OFDM Systems

    OpenAIRE

    Byung Moo Lee; Youngok Kim

    2017-01-01

    This paper presents a method to determine transmission power based on power amplifier (PA) operations in order to improve the energy efficiency (EE) of a large-scale (LS) Multiple Input Multiple Output (MIMO)-OFDM system, which is a multi-carrier multiple antenna system with a large amount of transmitter (TX) antennas. Regarding the EE improvement, we propose two kinds of PA operation schemes: increasing the effective TX power (ITXP) and reducing the PA power consumption (RPC) assuming that a...

  17. Dicty_cDB: Contig-U15147-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available . 44 8.8 1 ( EH698352 ) CCIS10174.b1_L23.ab1 CCI(LMS) chicory Cichorium i... 44 8.8 1 ( EY123909 ) NADL-aaa08g11.b1 Rhodnius_prolix...us_EST_NADL_RpcDN... 44 8.8 1 ( EY123642 ) NADL-aaa08g11.g1 Rhodnius_prolix

  18. Performance of low-resistivity single and dual-gap RPCs for LHCb

    CERN Document Server

    Adinolfi, M; Messi, R; Pacciani, L; Paoluzi, L; Santovetti, E

    2000-01-01

    Resistive plate chambers (RPC) are strong candidates for the outer regions of the LHCb muon detector. We have tested single-gap and dual-gap detectors built with low-resistivity phenolic plates ( rho =9*10/sup 9/ Omega cm) and operated in avalanche mode. Measurements have been performed over a wide range of beam intensities and on the GIF at CERN. The results are presented and discussed, with special emphasis on the detection efficiency. (6 refs).

  19. Top squark and neutralino decays in a R-parity violating model ...

    Indian Academy of Sciences (India)

    give mass to the SM fermions [2]. In our work we select a benchmark scenario [3] with a minimal set of six RPV parameters (µi,λi33; i = 1, 2, 3). For the choice. 839 ... The BRs of the ˜t1 decay modes and competition among the RPV and RPC decays ... BRs of the competing decay modes of the lighter top squark in the.

  20. Recent experimental results and developments on the resistive plate chambers for the CMS experiment

    CERN Document Server

    Altieri, S; Bruno, G; Guida, R; Merlo, M; Ratti, S P; Riccardi, C; Torre, P; Vitulo, P; Abbrescia, M; Colaleo, A; Iaselli, Giuseppe; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F

    2001-01-01

    Resistive plate chambers (RPC) have been chosen as dedicated trigger detectors for the CMS experiment at the LHC. The expected severe operating conditions have required an intense research and development activity on these detectors over the past years. Experimental results on overall performance of large chambers, rate capability, ageing and photon sensitivity are reviewed. In all of these tests the detector has proven to achieve good enough performance for successful use at the LHC. (6 refs).

  1. An overview of Linux container based network emulation

    CSIR Research Space (South Africa)

    Peach, Schalk

    2016-07-01

    Full Text Available Linkletter, 2015 provides reviews of most of the Container-Based Emulators discussed in this paper. The reviews provided are however focused on installation and usage. In contrast, this paper focuses on technical aspects of Container-Based Emulators..., a remote procedure call (RPC) application programming interface (API), a Python library and various user interface (UI) enhancements. Additional goals of the CORE project are to allow wireless network experiments through the Extendable Mobile Ad...

  2. Imaging diagnosis in relapsing polychondritis and correlation with clinical and serological data

    Energy Technology Data Exchange (ETDEWEB)

    Thaiss, W.M.; Nikolaou, K.; Horger, M. [Eberhard Karls University, Department of Radiology, Diagnostic and Interventional Radiology, Tuebingen (Germany); Spengler, W.; Xenitidis, T.; Henes, J. [Eberhard Karls University, Department of Internal Medicine II, Tuebingen (Germany); Spira, D. [Eberhard Karls University, Department of Radiology, Diagnostic and Interventional Radiology, Tuebingen (Germany); University Medical Center Heidelberg, Diagnostic and Interventional Radiology, Heidelberg (Germany)

    2016-03-15

    We hypothesize that imaging findings from CT and MRI correlate better with clinical markers for assessment of disease activity in patients with the rare relapsing polychondritis (RPC) than with serological inflammatory markers. Retrospective database search at our institution identified 28 patients (13 females; age 49.0 years ± 15.0 SD) with RP between September 2004 and March 2014. Institutional review board approval was obtained for this retrospective data analysis. All patients had clinically proven RPC with at least two episodes of active disease. Of those, 18 patients were examined with CT- and MRI and presented all morphologic features of RPC like bronchial/laryngeal/auricular cartilage thickness, contrast enhancement, increased T2-signal intensity. Imaging data was subsequently correlated with corresponding clinical symptoms like fever, dyspnea, stridor, uveitis, pain, hearing impairment as well as with acute-phase-inflammatory parameters like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The clinical parameters were in good agreement with imaging findings and clinical symptoms such as tracheal wall thickening and dyspnea (r =0.65 p = 0.05), joint synovitis on MRI and a higher McAdam score (r = 0.84 p < 0.001). No correlations were found between inflammatory laboratory markers, imaging findings and clinical features. Imaging diagnosis in RPC using CT and/or MRI delivers information about the degree of disease activity that correlates better with clinical features than unspecific inflammatory laboratory markers. Additionally, clinically unapparent cartilage involvement can be assessed adding value to the clinical diagnosis and therapy planning in this rare disease. (orig.)

  3. Client/server models for transparent, distributed computational resources

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, K.E.; Gilman, T.L.

    1991-01-01

    Client/server models are proposed to address issues of shared resources in a distributed, heterogeneous UNIX environment. Recent development of automated Remote Procedure Call (RPC) interface generator has simplified the development of client/server models. Previously, implementation of the models was only possible at the UNIX socket level. An overview of RPCs and the interface generator will be presented and will include a discussion of generation and installation of remote services, the RPC paradigm, and the three levels of RPC programming. Two applications, the Nuclear Plant Analyzer (NPA) and a fluids simulation using molecular modelling, will be presented to demonstrate how client/server models using RPCs and External Data Representations (XDR) have been used production/computation situations. The NPA incorporates a client/server interface for transferring/translation of TRAC or RELAP results from the UNICOS Cray to a UNIX workstation. The fluids simulation program utilizes the client/server model to access the Cray via a single function allowing it to become a shared co-processor to the workstation application. 5 refs., 6 figs.

  4. Performance and operation of the ATLAS Resistive Plate Chamber system in LHC Run-1

    CERN Document Server

    Boscherini, D; The ATLAS collaboration

    2014-01-01

    The barrel region of the ATLAS muon spectrometer is instrumented with a Resistive Plate Chamber (RPC) system covering the pseudo-rapidity range |η|<1.05 with a detector surface of almost 4000 m2. The RPCs, providing the first level trigger signal and the track coordinate in the non-bending plane for the candidate muons, have played a fundamental role in the physics studies carried out by ATLAS, culminated with the discovery of the Higgs boson. During the LHC Run-1 the RPC have shown excellent performances up to the maximum instantaneous luminosity of 0.7 × 1034 cm−2 s−1, corresponding approximately to 70% of the design value. The detector operation in the challenging background and pileup conditions of the LHC environment will be presented together with the problems encountered and their corresponding solutions. The plans for the maintenance and consolidation of the ATLAS RPC system during the current LHC shutdown, in view of the increased luminosity expected in Run-2, will be also presented.

  5. Assembly and Certification of ATLAS Muon Stations for the Middle and Outer Barrel at CERN

    CERN Document Server

    Aielli, G; Fleischmann, P; Iengo, P; Kovar, S; Wotschack, J; Zimmermann, S

    2006-01-01

    Roughly 400 of the approximately 700 muon stations of the ATLAS barrel belong to the middle and outer layer. Barrel Middle and Barrel Outer stations consist of both an MDT chamber and one or two RPC planes delivering the level-1 trigger information. While MDT chambers and individual RPC units are constructed at their home institutes, the assembly of the RPCs into planes, including the final cabling and the mounting of the trigger electronics, as well as the integration of MDTs and RPCs into muon stations takes place at CERN. MDT chambers, RPC planes and the completed stations have to pass a series of tests before being declared 'ready-for-installation'. Final certification criteria is the passing of a one-day cosmic ray test, for which a special setup has been built in building 899 (BB5). This note gives an overview over the work carried out in BB5, with emphasis on the cosmic ray test. Examples of abnormal chamber behavior will be discussed and a summary of common mistakes in station assembly or chamber cabl...

  6. Salutary value of haruan, the striped snakehead Channa striatus – a review

    Directory of Open Access Journals (Sweden)

    Mohammed Abdul Kader Haniffa

    2014-05-01

    Full Text Available Murrel namely Channa striatus or haruan contains all essential elements to maintain good health and to recover the lost energy after prolonged illness. The fatty acid composition (% of total fatty acid indicated the abundant presence of C16:0 fatty acid as 30% and the other major fatty acids were C22:6 (15%, C20:4 (19%, C18:1 (12% and C18:0 (15%. Haruan contains arachidonic acid (C20:4 as 19.0%, a precursor for prostaglandin and thromboxane biosyntheses. Both fatty and amino acids are important components for wound healing processes. Both the fillet and mucus extracts of haruan were found to exhibit a concentration dependent antinociceptive activity. In vitro antioxidant activity was higher in Channa roe protein hydrolysate than in Labeo roe protein hydrolysate in both DPPH radical scavenging and ferric reducing power. Protein content of roe concentrates (RPC was found to be 90.2% (Channa and 82.5% (Lates. Water absorption, oil absorption, foam capacity, stability and emulsifying capacity were found to be higher in Channa RPC than in Lates RPC. Characterization of protein hydrolysates from muscle and myofibrillar samples of haruan showed different kinetic and proteolytic activities. The skin extract of haruan influences the serotonergic receptor system thus they can function as an anti-depressant. Thus, haruan is the best example for food as medicine.

  7. Cytotoxicity of Dental Adhesives In Vitro

    Science.gov (United States)

    Koulaouzidou, Elisabeth A.; Helvatjoglu-Antoniades, Maria; Palaghias, George; Karanika-Kouma, Artemis; Antoniades, Dimitrios

    2009-01-01

    Objectives The purpose of this study was to evaluate the cytotoxic effect of six dental adhesives (Admira Bond, Clearfil Liner Bond 2V, ED Primer II, Fuji Bond LC, Gluma Comfort Bond, and NanoBond) applied to cell cultures. Methods The experiments were performed on two cell lines, rat pulp cells (RPC-C2A) and human lung fibroblasts (MRC5). Samples of the adhesives were light-cured and placed in culture medium for 24 hours. The extraction media was applied on the RPC-C2A and the MRC5 cells. Complete medium was used as a control. Cytotoxicity was evaluated with a modified sulforhodamine B (SRB) assay after 24 hours of exposure. Results The cell survival of RPC-C2A cells exposed to Fuji Bond LC, NanoBond, Clearfil Liner Bond 2V, ED Primer II, Admira Bond and Gluma Comfort Bond was 73%, 67%, 50%, 20%, 18% and 5% respectively, relative to the cell survival with the control medium. In the MRC5 cell line, the relative survival was 98%, 80%, 72%, 41%, 19% and 7% after exposure to NanoBond, Fuji Bond LC, Clearfil Liner Bond 2V, ED Primer II, Admira Bond and Gluma Comfort Bond, respectively. Conclusions Different types of dental adhesives showed different cytotoxic effects on cells in vitro. The self-etch adhesives were superior in terms of cytotoxicity. The different cytotoxic effects of dental adhesives should be considered when selecting an appropriate adhesive for operative restorations. PMID:19262725

  8. Cytotoxicity of dental adhesives in vitro.

    Science.gov (United States)

    Koulaouzidou, Elisabeth A; Helvatjoglu-Antoniades, Maria; Palaghias, George; Karanika-Kouma, Artemis; Antoniades, Dimitrios

    2009-01-01

    The purpose of this study was to evaluate the cytotoxic effect of six dental adhesives (Admira Bond, Clearfil Liner Bond 2V, ED Primer II, Fuji Bond LC, Gluma Comfort Bond, and NanoBond) applied to cell cultures. The experiments were performed on two cell lines, rat pulp cells (RPC-C2A) and human lung fibroblasts (MRC5). Samples of the adhesives were light-cured and placed in culture medium for 24 hours. The extraction media was applied on the RPC-C2A and the MRC5 cells. Complete medium was used as a control. Cytotoxicity was evaluated with a modified sulforhodamine B (SRB) assay after 24 hours of exposure. The cell survival of RPC-C2A cells exposed to Fuji Bond LC, NanoBond, Clearfil Liner Bond 2V, ED Primer II, Admira Bond and Gluma Comfort Bond was 73%, 67%, 50%, 20%, 18% and 5% respectively, relative to the cell survival with the control medium. In the MRC5 cell line, the relative survival was 98%, 80%, 72%, 41%, 19% and 7% after exposure to NanoBond, Fuji Bond LC, Clearfil Liner Bond 2V, ED Primer II, Admira Bond and Gluma Comfort Bond, respectively. Different types of dental adhesives showed different cytotoxic effects on cells in vitro. The self-etch adhesives were superior in terms of cytotoxicity. The different cytotoxic effects of dental adhesives should be considered when selecting an appropriate adhesive for operative restorations.

  9. MUON DETECTOR

    CERN Multimedia

    F. Gasparini

    Barrel Muons The last CMS week was dominated by the lowering of YB0. The date of lowering was fixed in January for February 28th. RPC and DT cabling of YB0 had to be done on the surface to allow a complete check of the status of the chambers before lowering. When the decision of the date was taken, the wheel cabling, planned to start at end of December, was not yet started for several “muon independent” reasons. Cabling and DT /RPC test started on Jan 22nd and ended on Feb 19th. Several teams worked on the surface of the wheel in parallel on the three different items, finishing just in time for lowering. This was a real challenge and a significant result. So by the end of the CMS Week, all the positive part of CMS plus YB0 were in the cavern. YB+2 had been lowered in January 19th, and YB+1 on February 1st. The vertical chambers of sectors 1 and 7 (8 DT/RPC packs), whose space was taken by the lowering machinery, had to be installed after lowering. This was done from Jan 24 to Jan 26 for...

  10. Transmission Power Determination Based on Power Amplifier Operations in Large-Scale MIMO-OFDM Systems

    Directory of Open Access Journals (Sweden)

    Byung Moo Lee

    2017-07-01

    Full Text Available This paper presents a method to determine transmission power based on power amplifier (PA operations in order to improve the energy efficiency (EE of a large-scale (LS Multiple Input Multiple Output (MIMO-OFDM system, which is a multi-carrier multiple antenna system with a large amount of transmitter (TX antennas. Regarding the EE improvement, we propose two kinds of PA operation schemes: increasing the effective TX power (ITXP and reducing the PA power consumption (RPC assuming that a reduction of peak-to-average power ratio is applied in the appropriate manner. Closed-form expressions of relative EE are derived for both schemes, and the relative EE of the ITXP scheme is shown to depend on the precoding method that is applied to reduce the inter-user interference, while that of the RPC scheme is independent of the precoding method. The relative EE difference between the ITXP and the RPC schemes is also shown to rely on the occupation ratio of the PA power consumption over the total power consumption. Thus, the EE can remarkably improve by selecting the appropriate scheme based on the circumstances. The results of a simulation also validate the derived closed-form expression of the relative EE.

  11. Using genetic algorithm and TOPSIS technique for multiobjective reactive power compensation

    Energy Technology Data Exchange (ETDEWEB)

    Azzam, M. [Department of Electrical Engineering, Faculty of Engineering, Mina University, Mina (Egypt); Mousa, A.A. [Department of Basic Engineering Sciences, Faculty of Engineering, Menoufia University, Shebin El-Kom (Egypt)

    2010-06-15

    A new approach to solve the multiobjective reactive power compensation (RPC) problem is presented. It is based on the combination of genetic algorithm (GA) and the {epsilon}-dominance concept. The algorithm maintains a finite-sized archive of nondominated solutions (Pareto solution) which gets iteratively updated in the presence of new solutions based on the concept of {epsilon}-dominance. The use of {epsilon}-dominance makes the algorithms practical by allowing a decision maker (DM) able to control the resolution of the Pareto set approximation according to his needs. The proposed approach is suitable to RPC problem where the objective functions may be ill-defined and having nonconvex Pareto-optimal front. It gives a reasonable freedom in choosing compensation devices from the available commercial devices. It may save computing time in cases of small archive. Moreover to help the DM to extract the best compromise solution from a finite set of alternatives a TOPSIS (Technique for Order Performance by Similarity to Ideal Solution) method is adopted. It is based upon simultaneous minimization of distance from an ideal point (IP) and maximization of distance from a nadir point (NP). The proposed approach is carried out on the standard IEEE 30-bus 6-generator test system. The results demonstrate the capabilities of the proposed approach to generate true and well-distributed Pareto-optimal nondominated solutions of the multiobjective RPC problem in one single run. (author)

  12. Regulation of Nutritional Metabolism in Transition Dairy Cows: Energy Homeostasis and Health in Response to Post-Ruminal Choline and Methionine.

    Science.gov (United States)

    Sun, Feifei; Cao, Yangchun; Cai, Chuanjiang; Li, Shengxiang; Yu, Chao; Yao, Junhu

    2016-01-01

    This study investigated the effects of rumen-protected methionine (RPM) and rumen-protected choline (RPC) on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum. Postpartum dry matter intake (DMI) was increased by both additives (P energy balance values in supplemented cows were improved after parturition (P ruminal choline and methionine elevated the blood antioxidant status, as indicated by total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) activity and the vitamin E concentration (P energy balance by increasing postpartal DMI and regulating hepatic lipid metabolism, improved postpartum lactation performance and enhanced antioxidant capacity and immune function of transition dairy cows.

  13. Performances of the ATLAS Level-1 Muon barrel trigger during the Run-II data taking

    CERN Document Server

    Sessa, Marco; The ATLAS collaboration

    2017-01-01

    The Level-1 Muon Barrel Trigger is one of the main elements of the event selection of the ATLAS experiment at the Large Hadron Collider. It exploits the Resistive Plate Chambers (RPC) detectors to generate the trigger signal. The RPCs are placed in the barrel region of the ATLAS experiment: they are arranged in three concentric double layers and operate in a strong magnetic toroidal field. RPC detectors cover the pseudo-rapidity range $|\\eta|<1.05$ for a total surface of more than $4000\\ m^2$ and about 3600 gas volumes. The Level-1 Muon Trigger in the barrel region allows to select muon candidates with respect to their transverse momentum and associates them with the correct bunch-crossing number. The trigger system is able to take a decision within a latency of about 2 $\\mu s$. The detailed measurement of the RPC detector efficiencies and of the trigger performance during the ATLAS Run-II data taking is here presented.

  14. CMS Resistive Plate Chambers performance at $\\sqrt{s}=$13 TeV

    CERN Document Server

    Cabrera Mora, Andres Leonardo

    2016-01-01

    During 2015, the Large Hadron Collider (LHC) at CERN has reached the record-breaking center-of-mass energy of 13 TeV for proton-proton collisions. The LHC restarted operations successfully after a two-year technical stop, known as Long Shutdown 1 (LS1), needed for servicing and consolidating the CERN accelerator complex. The Compact Muon Solenoid detector, a general-purpose detector at LHC, benefited from LS1 by performing crucial tasks necessary to operate the detector at higher energies. In particular, the Resistive Plate Chamber (RPC) system, one of the three muon detector technologies in CMS, was serviced, re-commissioned, and upgraded with 144 new chambers to enhance muon trigger efficiency. The CMS RPC system confers robustness and redundancy to the muon trigger. A total of 1056 double-gap chambers cover the pseudo-rapidity region $ \\lvert\\eta\\rvert \\leq$1.6. The CMS RPC collaboration has exploited early data samples at 13 TeV for detector performance studies. These data allowed for a first characte...

  15. dCache: implementing a high-end NFSv4.1 service using a Java NIO framework

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    dCache is a high performance scalable storage system widely used by HEP community. In addition to set of home grown protocols we also provide industry standard access mechanisms like WebDAV and NFSv4.1. This support places dCache as a direct competitor to commercial solutions. Nevertheless conforming to a protocol is not enough; our implementations must perform comparably or even better than commercial systems. To achieve this, dCache uses two high-end IO frameworks from well know application servers: GlassFish and JBoss. This presentation describes how we implemented an rfc1831 and rfc2203 compliant ONC RPC (Sun RPC) service based on the Grizzly NIO framework, part of the GlassFish application server. This ONC RPC service is the key component of dCache’s NFSv4.1 implementation, but is independent of dCache and available for other projects. We will also show some details of dCache NFS v4.1 implementations, describe some of the Java NIO techniques used and, finally, present details of our performance e...

  16. The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

    Directory of Open Access Journals (Sweden)

    Taejeong Ha

    2017-04-01

    Full Text Available Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal progenitor cells (RPCs by eliminating mindbomb E3 ubiquitin protein ligase 1 (Mib1. Mib1-deficient retinal cells failed to induce Notch activation in intra-lineage RPCs, which prematurely differentiated into neurons; however, Mib1 in post-mitotic retinal ganglion cells was not important. Interestingly, Mib1 in the retinal pigment epithelium (RPE also contributed to Notch activation in adjacent RPCs by supporting the localization of active Notch ligands at RPE-RPC contacts. Combining this RPE-driven Notch signaling and intra-retinal Notch signaling, we propose a model in which one RPC daughter receives extra Notch signals from the RPE to become an RPC, whereas its sister cell receives only a subthreshold level of intra-retinal Notch signal and differentiates into a neuron.

  17. The atmosphere of comet 67P/Churyumov-Gerasimenko diagnosed by charge-exchanged solar wind alpha particles

    Science.gov (United States)

    Simon Wedlund, C.; Kallio, E.; Alho, M.; Nilsson, H.; Stenberg Wieser, G.; Gunell, H.; Behar, E.; Pusa, J.; Gronoff, G.

    2016-03-01

    Context. The ESA/Rosetta mission has been orbiting comet 67P/Churyumov-Gerasimenko since August 2014, measuring its dayside plasma environment. The ion spectrometer onboard Rosetta has detected two ion populations, one energetic with a solar wind origin (H+, He2+, He+), the other at lower energies with a cometary origin (water group ions such as H2O+). He+ ions arise mainly from charge-exchange between solar wind alpha particles and cometary neutrals such as H2O. Aims: The He+ and He2+ ion fluxes measured by the Rosetta Plasma Consortium Ion Composition Analyser (RPC-ICA) give insight into the composition of the dayside neutral coma, into the importance of charge-exchange processes between the solar wind and cometary neutrals, and into the way these evolve when the comet draws closer to the Sun. Methods: We combine observations by the ion spectrometer RPC-ICA onboard Rosetta with calculations from an analytical model based on a collisionless neutral Haser atmosphere and nearly undisturbed solar wind conditions. Results: Equivalent neutral outgassing rates Q can be derived using the observed RPC-ICA He+/He2+ particle flux ratios as input into the analytical model in inverse mode. A revised dependence of Q on heliocentric distance Rh in AU is found to be Rh-7.06 between 1.8 and 3.3 AU, suggesting that the activity in 2015 differed from that of the 2008 perihelion passage. Conversely, using an outgassing rate determined from optical remote sensing measurements from Earth, the forward analytical model results are in relatively good agreement with the measured RPC-ICA flux ratios. Modelled ratios in a 2D spherically-symmetric plane are also presented, showing that charge exchange is most efficient with solar wind protons. Detailed cometocentric profiles of these ratios are also presented. Conclusions: In conclusion, we show that, with the help of a simple analytical model of charge-exchange processes, a mass-capable ion spectrometer such as RPC-ICA can be used as a

  18. Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration.

    Science.gov (United States)

    Qu, Zepeng; Guan, Yuan; Cui, Lu; Song, Jian; Gu, Junjie; Zhao, Hanzhi; Xu, Lei; Lu, Lixia; Jin, Ying; Xu, Guo-Tong

    2015-11-09

    Degenerative retinal diseases like age-related macular degeneration (AMD) are the leading cause of blindness. Cell transplantation showed promising therapeutic effect for such diseases, and embryonic stem cell (ESC) is one of the sources of such donor cells. Here, we aimed to generate retinal progenitor cells (RPCs) from rat ESCs (rESCs) and to test their therapeutic effects in rat model. The rESCs (DA8-16) were cultured in N2B27 medium with 2i, and differentiated to two types of RPCs following the SFEBq method with modifications. For rESC-RPC1, the cells were switched to adherent culture at D10, while for rESC-RPC2, the suspension culture was maintained to D14. Both RPCs were harvested at D16. Primary RPCs were obtained from P1 SD rats, and some of them were labeled with EGFP by infection with lentivirus. To generate Rax::EGFP knock-in rESC lines, TALENs were engineered to facilitate homologous recombination in rESCs, which were cotransfected with the targeting vector and TALEN vectors. The differentiated cells were analyzed with live image, immunofluorescence staining, flow cytometric analysis, gene expression microarray, etc. RCS rats were used to mimic the degeneration of retina and test the therapeutic effects of subretinally transplanted donor cells. The structure and function of retina were examined. We established two protocols through which two types of rESC-derived RPCs were obtained and both contained committed retina lineage cells and some neural progenitor cells (NPCs). These rESC-derived RPCs survived in the host retinas of RCS rats and protected the retinal structure and function in early stage following the transplantation. However, the glia enriched rESC-RPC1 obtained through early and longer adherent culture only increased the b-wave amplitude at 4 weeks, while the longer suspension culture gave rise to evidently neuronal differentiation in rESC-RPC2 which significantly improved the visual function of RCS rats. We have successfully differentiated

  19. Rabies Vaccine and Rabies Immunoglobulin in Cambodia: Use and Obstacles to Use.

    Science.gov (United States)

    Tarantola, Arnaud; Ly, Sowath; In, Sotheary; Ong, Sivuth; Peng, Yiksing; Heng, Nayyim; Buchy, Philippe

    2015-01-01

    Authorities have pledged to eliminate canine rabies by 2020 in Cambodia, a country with a very high rabies burden. Logistic and financial access to timely and adequate postexposure prophylaxis (PEP) is essential for preventing rabies in humans. We undertook a survey of the few identified sites where PEP rabies vaccination and rabies immunoglobulin (RIG) are available in Cambodia. We examined the Rabies Prevention Center at Institut Pasteur du Cambodge (rpc@ipc) database and rpc@ipc order forms for 2012 to assess vaccine and RIG use. We conducted a rapid internet survey of centers that provide rabies vaccine and RIG in Cambodia, other than rpc@ipc. The cost of a full course of intramuscular or intradermal PEP in Cambodia, with and without RIG, was also estimated. Rabies vaccination is free of charge in one foundation hospital and is accessible for a fee at Institut Pasteur du Cambodge (IPC), some institutions, and some Cambodian private clinics. In 2012, 27,500 rabies vaccine doses (0.5 mL) and 591 equine RIG doses were used to provide intradermal PEP to 20,610 persons at rpc@ipc following animal bites. Outside of rpc@ipc, an estimated total of 53,400 vaccine doses and 200 RIG doses were used in Cambodia in 2012. The wholesale cost of full rabies PEP was estimated at 50% to 100% of a Cambodian farmer's monthly wage. Local populations and travelers cannot be sure to locally access adequate and timely PEP due to high costs and low access to RIG. Travelers to high-endemic areas such as Cambodia are strongly encouraged to undergo pre-exposure vaccination or seek expert advice, as per World Health Organization (WHO) recommendations. State-subsidized, pre-positioned stocks of human vaccine and RIG in bite management centers would extend the rabies prevention centers network. Support from Institut Pasteur du Cambodge for staff training, cold chain, and quality control would contribute to reducing the risk of rabies deaths in Cambodia. © 2015 International Society of

  20. Development and implementation of a remote audit tool for high dose rate (HDR) Ir-192 brachytherapy using optically stimulated luminescence dosimetry.

    Science.gov (United States)

    Casey, Kevin E; Alvarez, Paola; Kry, Stephen F; Howell, Rebecca M; Lawyer, Ann; Followill, David

    2013-11-01

    The aim of this work was to create a mailable phantom with measurement accuracy suitable for Radiological Physics Center (RPC) audits of high dose-rate (HDR) brachytherapy sources at institutions participating in National Cancer Institute-funded cooperative clinical trials. Optically stimulated luminescence dosimeters (OSLDs) were chosen as the dosimeter to be used with the phantom. The authors designed and built an 8 × 8 × 10 cm(3) prototype phantom that had two slots capable of holding Al2O3:C OSLDs (nanoDots; Landauer, Glenwood, IL) and a single channel capable of accepting all (192)Ir HDR brachytherapy sources in current clinical use in the United States. The authors irradiated the phantom with Nucletron and Varian (192)Ir HDR sources in order to determine correction factors for linearity with dose and the combined effects of irradiation energy and phantom characteristics. The phantom was then sent to eight institutions which volunteered to perform trial remote audits. The linearity correction factor was kL = (-9.43 × 10(-5) × dose) + 1.009, where dose is in cGy, which differed from that determined by the RPC for the same batch of dosimeters using (60)Co irradiation. Separate block correction factors were determined for current versions of both Nucletron and Varian (192)Ir HDR sources and these vendor-specific correction factors differed by almost 2.6%. For the Nucletron source, the correction factor was 1.026 [95% confidence interval (CI) = 1.023-1.028], and for the Varian source, it was 1.000 (95% CI = 0.995-1.005). Variations in lateral source positioning up to 0.8 mm and distal∕proximal source positioning up to 10 mm had minimal effect on dose measurement accuracy. The overall dose measurement uncertainty of the system was estimated to be 2.4% and 2.5% for the Nucletron and Varian sources, respectively (95% CI). This uncertainty was sufficient to establish a ± 5% acceptance criterion for source strength audits under a formal RPC audit program. Trial

  1. Clostridium difficile infection after restorative proctocolectomy and ileal pouch anal anastomosis for ulcerative colitis.

    Science.gov (United States)

    Martinez Ugarte, M L; Lightner, A L; Colibaseanu, D; Khanna, S; Pardi, D S; Dozois, E J; Mathis, K L

    2016-05-01

    Clostridium difficile infection (CDI) of the ileal pouch following restorative proctocolectomy (RPC) is becoming increasingly recognized. We aimed to understand better (i) the associated risk factors, (ii) treatment practices and (iii) the pouch diversion and failure rate in patients who developed CDI of the pouch after RPC for ulcerative colitis (UC). Patients who tested positive for C. difficile of the pouch between 2007 and 2010 were included in the analysis. Data collected included patient demographics, time from RPC to documented CDI, the treatment of CDI and rate of excision of the pouch. Of 2785 patients recorded in the hospital CDI database, 15 had had an RPC with ileal pouch anal anastomosis. The median age was 44 years and the median interval from RPC to first documented episode of CDI was 3 years. Thirteen (81%) patients had had multiple episodes of pouchitis before and after CDI infection, and all were symptomatic at the time of testing for CDI. Within 30 days of the diagnosis of CDI, six (40%) patients were taking immunosuppressive medication, seven (47%) were taking a proton pump inhibitor and 12 (80%) had received antibiotics. Five patients required hospitalization for CDI and four had severe infections characterized by a serum creatinine more than 1.5 times baseline (n = 3) and a white cell count above 15 000 (n = 1). Six patients who underwent endoscopy had severe inflammation of the pouch including the presence of a pseudomembrane in one case. Ten patients were treated with metronidazole alone and five with vancomycin. Two patients had recurrent CDI of the pouch during a median follow-up period of 2.9 years and one had CDI refractory to medical management. This patient required diversion of the pouch with an ileostomy for refractory CDI but no patient required excision of the pouch. All 15 patients developing CDI of the pouch were successfully treated with antibiotics and only one required surgery in the form of an ileostomy. Colorectal

  2. The BaBar instrumented flux return performance: lessons learned

    CERN Document Server

    Anulli, F; Baldini, R; Band, H R; Bionta, R; Brau, J E; Brigljevic, V; Buzzo, A; Calcaterra, A; Carpinelli, M; Cartaro, C; Cavallo, N; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Eichenbaum, A; Fabozzi, F; Falciai, D; Ferrarotto, F; Ferroni, F; Finocchiaro, G; Forti, F; Frey, R; Gatto, C; Graug; Iakovlev, N I; Iwasaki, M; Johnson, J R; Lange, D J; Lista, L; Lo Vetere, M; Lü, C; Macri, M; Messner, R; Moore, T B; Morganti, S; Neal, H; Neri, N; Palano, A; Paoloni, E; Paolucci, P; Passaggio, S; Pastore, F C; Patteri, P; Peruzzi, I; Piccolo, D; Piccolo, M; Piredda, G; Robutti, E; Roodman, A; Santroni, A; Sciacca, C; Sinev, N B; Soha, A; Strom, D; Tosi, S; Vavra, J; Wisniewski, W J; Wright, D M; Xie, Y; Zallo, A

    2002-01-01

    The BaBar Collaboration has operated an instrumented flux return (IFR) system covering over 2000 m sup 2 with resistive plate chambers (RPCs) for nearly 3 years. The chambers are constructed of bakelite sheets separated by 2 mm. The inner surfaces are coated with linseed oil. This system provides muon and neutral hadron detection for BaBar. Installation and commissioning were completed in 1998, and operation began mid-year 1999. While initial performance of the system reached design, over time, a significant fraction of the RPCs demonstrated significant degradation, marked by increased currents and reduced efficiency. A coordinated effort of investigations have identified many of the elements responsible for the degradation. This article presents our current understanding of the aging process of the BaBar RPCs along with the action plan to combat performance degradation of the IFR system.

  3. Disruptive change and the reconfiguration of innovation ecosystems

    Directory of Open Access Journals (Sweden)

    Ozgur Dedehayir

    2017-10-01

    Full Text Available This conceptual paper extends the traditional view of disruptive change, which considers the effects of rivalry between an incumbent and new entrant firm, by examining the impact of disruption upon the ‘innovation ecosystem’ in its entirety – the group of organisations that collaborate in creating a holistic value proposition for the end-user. Following Adner’s “ecosystem-as-structure” perspective, we develop propositions that anticipate structural differences between incumbent and disruptive innovation ecosystems, and then review these propositions in the context of three historical, disruptive innovation cases; Bakelite (a synthetic plastic, microwave oven, and photocopier. Through these cases, we illustrate that the manner of innovation ecosystem reconfiguration is likely to depend on the design attributes of the product, as well as the type of disruption experienced. We conclude by reflecting upon contemporary cases of disruption enabled through digital technologies, and proposing a framework that can guide future research.

  4. Chemical reaction engineering studies on cocracking of petroleum vacuum residue with coal, plastics, and biomass (bagasse and petrocrop)

    Energy Technology Data Exchange (ETDEWEB)

    Ahmaruzzaman, M.; Sharma, D.K. [Indian Institute of Technology, New Delhi (India). Centre for Energy Studies

    2007-07-01

    This article deals with the studies on cocracking of petroleum vacuum residue (XVR) with thermosetting plastic, I. e., bakelite (BL), Samla coal (SC), biomass, I. e., bagasse (BG) or C. procera (CL) and their binary, ternary, and quaternary mixtures in a thermogravimetric analyzer (TGA). The kinetic studies were performed using the Coats and Redfern kinetic modeling equation. The overall activation energies obtained were 25 kJ/mole for petroleum vacuum residue, 99 kJ/mole for polypropylene, 21 kJ/mole for coal, 23 kJ/mole for Calotropis procera, and 25 kJ/mole for the combination of these four materials. However, other models, such as van Krevelan et al. and Horowitz and Metzger have also been used in some cases to compare the results with those obtained by the Coats and Redfern kinetic models. In the present work, the effect of catalysts on the cracking of Basra vacuum residue (BVR) has also been reported.

  5. Long-term operation test of RPCs for the OPERA experiment

    CERN Document Server

    Barichello, G; Brugnera, R; Candela, A; Carrara, E; D'Incecco, M; Dal Corso, F; Degli Esposti, L; Dusini, S; Garfagnini, A; Gustavino, C; Lindozzi, M; Mengucci, A; Monacelli, P; Paoloni, A; Spinetti, M; Stanco, L; Terranova, F; Ventura, M; Votano, L

    2004-01-01

    OPERA is one of the two detectors foreseen in the CERN Neutrino to Gran Sasso project, devoted to the detection of nu//mu into nu //tau oscillations in the parameter region suggested by SuperKamiokande data on atmospheric neutrinos. Bakelite RPCs will be used to instrument the iron yoke of the muon spectrometers. We present the results of long-term (greater than 6 months) streamer operations of real size OPERA RPCs at cosmic rays fluxes. Given the very low rate observed in the underground Gran Sasso Laboratories, under 3 km w.e., even this short time period is equivalent to more than 10 OPERA years. Results of tests with different gas mixtures are reported, in view of decreasing the streamer charge of operation for the RPCs employed in the experiment.

  6. Autoradiographic technic for Plutonium, Polonium, and Promethium tissue sections

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, S.G.

    1978-03-01

    Syrian hamster lung sections containing /sup 238/Pu, /sup 239/Pu, /sup 210/Po, or /sup 147/Pm are deparaffinized and hydrated to water. The slides are dipped in NTB emulsion, allowed to dry overnight, and exposed in Bakelite boxes at room temperature. They are then developed in D-19 for two to four minutes, rinsed in distilled water for ten seconds, fixed in Kodak fixer for five minutes, and washed at least 30 minutes in distilled water before staining with nuclear fast red and indigo-carmine. This autoradiographic technic, in conjunction with this particular staining procedure, gives a quick, efficient method for working with different ..cap alpha..- and ..beta..-emitting radionuclides.

  7. Effect of sample thickness on the measured mass attenuation coefficients of some compounds and elements for 59.54, 661.6 and 1332.5 keV gamma-rays

    CERN Document Server

    El-Rahman, M A; Abdel-Hady, Y L; Kamel, N

    2000-01-01

    Measurements have been made to determine gamma-rays attenuation coefficients very accurately by using an extremely narrow-collimated-beam transmission method. The effect of the sample thickness on the measured values of the mass attenuation coefficients (mu/rho) cm sup 2 /g of perspex, bakelite, paraffin, Al, Cu, Pb and Hg have been investigated at three different gamma-ray energies (59.54, 661.6 and 1332.5 keV). It is seen that for these chosen materials (mu/rho) remains constant in good agreement with the theoretical values up to 3 mean free paths and after that (mu/rho) values for Cu, Pb and Hg decrease with further increase in the absorber thickness. This result may be attributed to the increase in the number of coherent small-angle scattering photons which reach the detector.

  8. Performance and simulation of a double-gap resistive plate chamber in the avalanche mode

    CERN Document Server

    Ahn Sung Hwan; Hong Byung Sik; Hong Seong Jong; Ito, M; Kang, T I; Kim, B I; Kim, J H; Kim, Y J; Kim, Y U; Koo, D G; Lee Hyup Woo; Lee, K B; Lee Kyong Sei; Lee Seok Jae; Lim, J K; Moon, D H; Nam, S K; Park, S; Park, W J; Rhee June Tak; Ryu, M S; Sim Kwang Souk

    2004-01-01

    We present a detailed analysis of the time and the charge signals of a prototype double-gap resistive plate chamber for the endcap region of the Compact Muon Solenoid (CMS) detector at the Large Hadron Collider (LHC). The chamber was built with relatively low-resistivity bakelite. The time and the charge results demonstrate that the high- voltage plateau, which satisfies various CMS requirements for the efficiency, the noise cluster rate, the fraction of the large signal, and the streamer probability, can be extended at least up to 400 V with the present design. In addition, a simple avalanche multiplication model is studied in detail. The model can reproduce the experimental charge spectra reasonably well. The charge information enables us to estimate the effective Townsend coefficient in avalanche-mode operation.

  9. PERFORMANCE ANALYSIS OF RECTANGULAR MPA USING DIFFERENT SUBSTRATE MATERIALS FOR WLAN APPLICATION

    Directory of Open Access Journals (Sweden)

    E Aravindraj

    2017-03-01

    Full Text Available In this paper, a rectangular microstrip patch antenna (MPA is designed using different substrate materials for analyzing the performance of the MPA. Alumina (Al2O3, Bakelite, Beryllium oxide (BeO, Gallium Arsenide (GaAs, RT-Duroid and Flame Retardant 4 (FR-4 are the six different substrate used in the design. The size of the rectangular microstrip patch antenna varies according to the dielectric constant of substrate materials used. The operating frequency taken for this analysis is 5.8 GHz. The proposed design provides the study on the performance of rectangular microstrip patch antenna for different substrate materials using the same frequency. This study conveys that which substrate material provides better performance. Moreover, this comparative study conveys that which substrate material provides better performance. The simulation parameters are investigated using HFSS.

  10. The Rapid Emergence of High Level Gentamicin Resistance in Enterococci

    Directory of Open Access Journals (Sweden)

    Kevin R Forward

    1990-01-01

    Full Text Available The proportion of enterococci isolated from blood and urine cultures that were highly resistant to gentamicin and streptomycin were determined. No blood or urine isolates highly resistant to gentamicin were seen in 1983, whereas by 1986–87 25% of blood and 17% of urine isolates were highly resistant. The rapid emergence of gentamicin resistance has serious implications for patients with life threatening enterococcal disease.

  11. The Rapid Emergence of High Level Gentamicin Resistance in Enterococci

    OpenAIRE

    Forward, Kevin R; Kennedy, James K; Degagne, Patricia A; Bartlett, Kathy R; Harding, Godfrey KM

    1990-01-01

    The proportion of enterococci isolated from blood and urine cultures that were highly resistant to gentamicin and streptomycin were determined. No blood or urine isolates highly resistant to gentamicin were seen in 1983, whereas by 1986–87 25% of blood and 17% of urine isolates were highly resistant. The rapid emergence of gentamicin resistance has serious implications for patients with life threatening enterococcal disease.

  12. The Shrinkage Cracking Behavior in Reinforced Reactive Powder Concrete Walls

    Directory of Open Access Journals (Sweden)

    Samir A. Al-Mashhadi

    2017-07-01

    Full Text Available In this study, the reduced scale wall models were used (they are believed to resemble as much as possible the field conditions to study the shrinkage behavior of reactive powder concrete (RPC base restrained walls. Six base restrained RPC walls were casted in different length/height ratios of two ratios of steel fiber by volume in Summer. These walls were restrained by reinforced concrete bases to provide the continuous base restraint to the walls. The mechanical properties of reactive powder concrete investigated were; compressive strength between (75.3 – 140.1 MPa, splitting tensile strength between (5.7 – 13.9 MPa, flexural tensile strength (7.7 – 24.5 MPa, and static modulus of elasticity (32.7 – 47.1GPa. Based on the observations of this work, it was found that the cracks did not develop in the reduced scale of the reactive powder concrete (RPC walls restrained from movement at their bases for different L/H ratios (2, 5, and 10 and for two ratio of steel fiber (1% & 2% during 90 days period of drying conditions. Moreover, the shrinkage values increase toward the edges. Based on the results of this work, the increase in the maximum shrinkage values of walls with 1% steel fiber were (29%, 28%, 28% of the maximum shrinkage values of walls with 2% steel fiber of length/height ratios of (2, 5, and 10 respectively. The experimental observation in beam specimens showed that the free shrinkage, tensile strain capacity and elastic tensile strain capacity (at date of cracking of beams with 1% steel fiber were higher than the beams with 2% steel fiber by about (24%, (45% and (42% respectively

  13. Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments

    Energy Technology Data Exchange (ETDEWEB)

    Ranaei Pirmardan, Ehsan [Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Soheili, Zahra-Soheila [Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran (Iran, Islamic Republic of); Samiei, Shahram [Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran (Iran, Islamic Republic of); Ahmadieh, Hamid [Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran (Iran, Islamic Republic of); Mowla, Seyed Javad [Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Ezzati, Razie [Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran (Iran, Islamic Republic of); Naseri, Marzieh [Department of Molecular Medicine, Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2016-10-01

    Retinal pigmented epithelium (RPE), the outermost layer of the retina, has a key role in maintaining retinal cells’ functions. Severity of the culture of RPE cells has exerted many limitations to both in vitro and in vivo studies and its therapeutic applications. Therefore, establishment of RPE cell lines with high proliferative potential can considerably improve study of RPE cell biology. Here we report generation of a spontaneously immortalized murine RPE cell line in primary mouse RPE cell culture. Founded colonized cells were picked up and expression of RPE and retinal progenitor cells’ (RPC) markers were studied using immunocytochemistry (ICC). Emerged cells cultured over 35 passages and population doubling times in different serum concentrations were calculated. We also investigated the ability of cells for becoming transfected by calcium-phosphate method and for becoming infected by adeno-associated virus serotype 2 (AAV2) using flow cytometry. Data showed that the cobblestone constituent cells expressed RPE65, cytokeratin and ZO1 and moreover several progenitor markers such as Pax6, Sox2, Nestin and Chx10. It revealed that, despite primary RPE cells, the newly emerged cells were easily transfectable and were highly infectable when compared with HEK293T cells. Our data indicated that the emerged mouse RPE cell line pretended RPC-like phenotype and also simultaneously expressed RPE markers. It would be a promising model for leading studies on RPE and RPC cells and substantially confirmed the great RPE plasticity and its invaluable potential in research studies. - Highlights: • Isolation of a spontaneously generated retinal pigmented epithelium cell line is reported. • The cells express some of the retinal progenitor cell markers in addition to the RPE markers. • The aforesaid cell line is highly transfecable and considerably infectable by AAV2. • These results confirm the great RPE plasticity and its invaluable potential in research studies.

  14. Sharing programming resources between Bio* projects through remote procedure call and native call stack strategies.

    Science.gov (United States)

    Prins, Pjotr; Goto, Naohisa; Yates, Andrew; Gautier, Laurent; Willis, Scooter; Fields, Christopher; Katayama, Toshiaki

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times for different languages, it is possible to share components by bridging computer languages and Bio* projects, such as BioPerl, Biopython, BioRuby, BioJava, and R/Bioconductor. In this chapter, we compare the two principal approaches for sharing software between different programming languages: either by remote procedure call (RPC) or by sharing a local call stack. RPC provides a language-independent protocol over a network interface; examples are RSOAP and Rserve. The local call stack provides a between-language mapping not over the network interface, but directly in computer memory; examples are R bindings, RPy, and languages sharing the Java Virtual Machine stack. This functionality provides strategies for sharing of software between Bio* projects, which can be exploited more often. Here, we present cross-language examples for sequence translation, and measure throughput of the different options. We compare calling into R through native R, RSOAP, Rserve, and RPy interfaces, with the performance of native BioPerl, Biopython, BioJava, and BioRuby implementations, and with call stack bindings to BioJava and the European Molecular Biology Open Software Suite. In general, call stack approaches outperform native Bio* implementations and these, in turn, outperform RPC-based approaches. To test and compare strategies, we provide a downloadable BioNode image with all examples, tools, and libraries included. The BioNode image can be run on VirtualBox-supported operating systems, including Windows, OSX, and Linux.

  15. Seasonal, gender and regional variations in total phenolic, flavonoid, and condensed tannins contents and in antioxidant properties from Pistacia atlantica ssp. leaves.

    Science.gov (United States)

    Ben Ahmed, Ziyad; Yousfi, Mohamed; Viaene, Johan; Dejaegher, Bieke; Demeyer, Kristiaan; Mangelings, Debby; Vander Heyden, Yvan

    2017-12-01

    The widespread use of Pistacia atlantica Desf. ssp. (Anacardiaceae) in traditional medicine can be partly attributed to the content of its secondary metabolites, in particular, the phenolic compounds. The effects of harvest period, growing region and gender on the phenolic compounds, flavonoids and condensed tannins contents were studied, as well as on the antioxidant activities of P. atlantica leaves in order to provide a scientific basis for optimal collection. Leaves were collected monthly from April to October 2010 in two Algerian sites. The powdered leaves were used for preparing the ethyl acetate extract. Contents of total phenolics (TPC), flavonoids (FC) and condensed tannins (CTC) were determined spectrophotometrically. Antioxidant activity was evaluated through radical scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (250 μM) and the reducing power capacity (RPC) determination by K 3 Fe(CN) 6 (1%). The TPC was found to vary from 79 ± 13 to 259 ± 8 mg gallic acid equivalents/g of dry weight (DW) during the study period. The RSA and RPC varied between 262 ± 18 and 675 ± 21 mg Ascorbic Acid Equivalent (AAE)/g DW, and from 259 ± 16 to 983 ± 20 mg AAE/g DW, respectively. A seasonal pattern was observed consisting of a decrease in TPC content and RPC from spring to autumn. The FC, CTC and RSA did not show a seasonal pattern. Our findings showed that secondary metabolite content and antioxidant activities of P. atlantica leaves were more influenced by harvest time and growing region than by gender.

  16. [Clinical analysis of 123 cases of transitional cell carcinoma (TCC) of upper urinary tract].

    Science.gov (United States)

    Liang, Yue-You; Dai, Yu-Ping; Huang, Zheng-Yu; Zheng, Ke-Li; Mei, Hua

    2005-01-01

    With the development of diagnostic techniques of imaging, and application of endoscope, early diagnosis and treatment of transitional cell carcinoma (TCC) of upper urinary tract have been improved to a great extent in recent years, but still caused debates. In this article, we discussed the diagnostic and therapeutic methods of TCC of upper urinary tract. Clinical data of 123 patients with TCC of upper urinary tract treated in our hospital from Mar. 1996 to Dec. 2003 were retrospectively analyzed. Ratios of final diagnosis of renal pelvic cancer (RPC) by B ultrasound, intravenous pyelogram (IVP), and computed tomography (CT) were 82.1% (46/56), 37.1% (20/54), and 88.1% (37/42), respectively; those of ureter cancer were 11.8% (4/34), 3.2% (1/31), and 93.8% (15/16), respectively. Successful retrograde pyelography could locate both kinds of carcinomas accurately. Of 123 patients, 116 underwent radical surgery, and 7 given up for metastasis or poor heart and lung function; 107(87.0%) were followed-up with a mean of 3.5 years. Three-year survival rates of patients with superficial RPC (stage T1), and invasive RPC (stages T2-T4, or N1, N2) were 94.1%, and 73.6%; 5-year survival rates were 88.2%, and 43.3%. Three-year survival rates of patients with superficial ureter cancer, and invasive ureter cancer were 100%, and 68.8%; 5-year survival rates were 80.0%, and 40.6%. Bladder tumor occurred in 29 (23.6%) patients. Combination of IVP and B ultrasound should be used as a routine examination for TCC of upper urinary tract. Retrograde pyelography may be used as an adjuvant examination when IVP showed negative results, CT may be used for further examination. Radical resection of kidney and ureter is the preferred treatment for this disease.

  17. The IceProd Framework

    DEFF Research Database (Denmark)

    Aartsen, M.G.; Abbasi, R.; Ackermann, M.

    2015-01-01

    IceCube is a one-gigaton instrument located at the geographic South Pole, designed to detect cosmic neutrinos, iden- tify the particle nature of dark matter, and study high-energy neutrinos themselves. Simulation of the IceCube detector and processing of data require a significant amount...... of computational resources. IceProd is a distributed management system based on Python, XML-RPC and GridFTP. It is driven by a central database in order to coordinate and admin- ister production of simulations and processing of data produced by the IceCube detector. IceProd runs as a separate layer on top of other...

  18. A Novel UV Photon Detector with Resistive Electrodes

    CERN Document Server

    Bidault, J M; Francke, T; Galy, P; Peskov, Vladimir; Rodionov, I

    2006-01-01

    In this study we present first results from a new detector of UV photons: a thick gaseous electron multiplier (GEM) with resistive electrodes, combined with CsI or CsTe/CsI photocathodes. The hole type structure considerably suppresses the photon and ion feedback, whereas the resistive electrodes protect the detector and the readout electronics from damage by any eventual discharges. This device reaches higher gains than a previously developed photosensitive RPC and could be used not only for the imaging of UV sources, flames or Cherenkov light, for example, but also for the detection of X-rays and charged particles.

  19. The upgraded K-Long and Muon Detector at Belle II

    Science.gov (United States)

    Kimmel, Taylor; Belle Collaboration, II

    2017-01-01

    We describe the KLM (KLong-Muon) detector for the Belle II detector at the SuperKEKB accelerator located at KEK in Tsukuba, Japan. The endcap RPC (Resistive Plate Chamber) detectors used for Belle have been entirely replaced with a scintillator-based system readout out with Si PMTs. The inner two layers of the barrel have also been replaced, while the outer thirteen layers remain instrumented with RPCs. The design of the detectors, their readout, and expected physics performance will be discussed.

  20. qooxdoo Beginner's Guide

    CERN Document Server

    Raffi, Mohamed

    2011-01-01

    This is a Packt beginner's guide. The unique style of the book is to set the requirements for an application, Team Twitter, in the first chapter and apply the concepts in the application as you learn in the following chapters. When you complete this book, you would have developed a complete application. Although the scope of this book is only on the Qooxdoo framework, which is a client side framework, we have explained how to set up one of the RPC servers and demonstrated the end to end application in the Team Twitter. This book is intended for the client side developers who design and develop

  1. Simulation of resistive plate chamber sensitivity to neutrons

    CERN Document Server

    Altieri, S; Bruno, G; Merlo, M; Ratti, S P; Riccardi, C; Torre, P; Vitulo, P; Abbrescia, M; Colaleo, A; Iaselli, Giuseppe; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F

    2001-01-01

    The Resistive Plate Chambers (RPCs) sensitivity to neutrons has been simulated using GEANT code with MICAP and FLUKA interfaces. The calculations have been performed as a function of the neutrons energy in the range 0.02 eV-1 GeV. To evaluate the response of the detector in the IHC background environment, the neutron energy spectrum expected in the CMS muon barrel has been taken into account; a hit rate due to neutrons of about 0.6 Hz cm/sup -2/ has been estimated for a 250*250 cm/sup 2/ RPC in the RB1 station. (2 refs).

  2. Algorithm and implementation of muon trigger and data transmission system for barrel-endcap overlap region of the CMS detector

    CERN Document Server

    AUTHOR|(CDS)2072021; Byszuk, Adrian Pawel

    2016-01-01

    The CMS experiment is currently undergoing upgrade of its trigger, including the Level-1 muon trigger. In the barrel-endcap transition region it is necessary to merge data from 3 types of detectors - RPC, DT and CSC. The Overlap Muon Track Finder (OMTF) uses the novelty approach to concentrate and process those data in an uniform manner. The paper presents the algorithm and FPGA firmware implementation of the OMTF and its data transmission system in CMS. The OMTF is subject to significant changes during optimizations based on physical simulations. Therefore a special, high level, parametrized HDL implementation is necessary.

  3. Ultrasound assisted methods for enhanced extraction of phycobiliproteins from marine macro-algae, Gelidium pusillum (Rhodophyta).

    Science.gov (United States)

    Mittal, Rochak; Tavanandi, Hrishikesh A; Mantri, Vaibhav A; Raghavarao, K S M S

    2017-09-01

    Extraction of phycobiliproteins (R-phycoerythrin, R-PE and R-phycocyanin, R-PC) from macro-algae is difficult due to the presence of large polysaccharides (agar, cellulose etc.) present in the cell wall which offer major hindrance for cell disruption. The present study is aimed at developing most suitable methodology for the primary extraction of R-PE and R-PC from marine macro-algae, Gelidium pusillum(Stackhouse) Le Jolis. Such extraction of phycobiliproteins by using ultrasonication and other conventional methods such as maceration, maceration in presence of liquid nitrogen, homogenization, and freezing and thawing (alone and in combinations) is reported for the first time. Standardization of ultrasonication for different parameters such as ultrasonication amplitude (60, 90 and 120µm) and ultrasonication time (1, 2, 4, 6, 8 and 10mins) at different temperatures (30, 35 and 40°C) was carried out. Kinetic parameters were estimated for extraction of phycobiliproteins by ultrasonication based on second order mass transfer kinetics. Based on calorimetric measurements, power, ultrasound intensity and acoustic power density were estimated to be 41.97W, 14.81W/cm2 and 0.419W/cm3, respectively. Synergistic effect of ultrasonication was observed when employed in combination with other conventional primary extraction methods. Homogenization in combination with ultrasonication resulted in an enhancement in efficiency by 9.3% over homogenization alone. Similarly, maceration in combination with ultrasonication resulted in an enhancement in efficiency by 31% over maceration alone. Among all the methods employed, maceration in combination with ultrasonication resulted in the highest extraction efficiency of 77 and 93% for R-PE and R-PC, respectively followed by homogenization in combination with ultrasonication (69.6% for R-PE and 74.1% for R-PC). HPLC analysis was carried out in order to ensure that R-PE was present in the extract and remained intact even after processing

  4. Atmospheric Attenuation of Millimeter and Submillimeter Waves: Models and Computer Code

    Science.gov (United States)

    1979-10-15

    oli i (f o.tl olwn ,.,...ssŕ𔄀: TZ - a.Th ai prnite enurdbn MI0l0- a -- tSU VtsR bu h aaee o rprac i satrn rp-c i- bji’l Tlw M 11--P disi, ribiut iont...Contract NAS-5-21624. iaan, Mei-Yuan (19 ) Microstructure of c-ujulus clouds, Isv. Geophys. 8er. No. 2:362-376, tUogg, D.C. and Chu , T S. (1975) The role

  5. Twisted network programming essentials

    CERN Document Server

    Fettig, Abe

    2005-01-01

    Twisted Network Programming Essentials from O'Reilly is a task-oriented look at this new open source, Python-based technology. The book begins with recommendations for various plug-ins and add-ons to enhance the basic package as installed. It then details Twisted's collection simple network protocols, and helper utilities. The book also includes projects that let you try out the Twisted framework for yourself. For example, you'll find examples of using Twisted to build web services applications using the REST architecture, using XML-RPC, and using SOAP. Written for developers who want to s

  6. The EEE Project: Cosmic rays, multigap resistive plate chambers and high school students

    CERN Document Server

    Abbrescia, M.; Antolini, R; Avanzini, C; Baldini Ferroli, R; Bencivenni, G; Bossini, E; Bressan, E; Chiavassa, A; Cicalo, C; Cifarelli, L; Coccia, E; De Gruttula, D; De Pasquale, S; Di Giovanni, A; D'Incecco, M; Doroud, K; Dreucci, M; Fabbri, FL; Frolov, V; Garbini, M; Gemme, G; Gnesi, I; Gustavino, C; Hatzifotiadu, D; La Rocca, P; Li, S; Moro, R; Miozzi, S; Massai, M; Maggiora, A; Librizzi, F; Piragino, G; Pilo, F; Perasso, L; Paoletti, R; Righini, GC; Scapparone, E; Sartorelli, G; Romano, F; Serci, S; Selvi, M; Scribano, A; Riggi, F; Regano, A; Squarcia, S; Spandre, G; Toselli, F; Taiuti, M; Zichichi, A; Zouyevski, R; Williams, MCS; Votano, L; Siddi, E; Panareo, M

    2012-01-01

    The Gas Gain Monitoring (GGM) system of the Resistive Plate Chamber (RPC) muon detector in the Compact Muon Solenoid (CMS) experiment provides fast and accurate determination of the stability in the working point conditions due to gas mixture changes in the closed loop recirculation system. In 2011 the GGM began to operate using a feedback algorithm to control the applied voltage, in order to keep the GGM response insensitive to environmental temperature and atmospheric pressure variations. Recent results are presented on the feedback method used and on alternative algorithms.

  7. ICFA Instrumentation Bulletin, Volume 23, Fall 2001 Issue (SLAC-J-ICFA-023)

    Energy Technology Data Exchange (ETDEWEB)

    Va' Vra, J.

    2003-10-21

    The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation. This issue has the following articles: (1) ''A Large Area Timing RPC''; (2) ''Applications and New Developments in Resistive Plate Chambers''; and (3) ''Advanced Study of Silicon Photomultipliers''.

  8. Threshold dependence of strip clusters for the forward region resistive plate chamber of the CMS/LHC experiment

    CERN Document Server

    Ahn, S H; Choi, E J; Hong, B; Hong, S J; Jung, S R; Kim, T J; Kim, Y J; Kim, Y U; Koo, D G; Lee, H W; Lee, K S; Lee, Y L; Lee, S B; Lee, S J; Nam, S K; Oh, J K; Park, M K; Park, S; Park, W J; Rhee, J T; Ryu, M S; Shim, H H; Sim, K S; Woo, J K

    2003-01-01

    Strip clusters of muons and background hits induced by gamma rays and spurious pulses are analyzed for the Forward Region Resistive Plate Chamber of the CMS/LHC. In order to perform the analysis, a real size RE2/1 prototype RPC manufactured with the final baseline design of the Forward Region RPCs was tested at the Gamma Irradiation Facility of CERN. Strip cluster sizes for muons and strip cluster rates for gamma rays are sensitive to the threshold setting while the efficiency to muons is relatively insensitive.

  9. Scalable web services for the PSIPRED Protein Analysis Workbench.

    Science.gov (United States)

    Buchan, Daniel W A; Minneci, Federico; Nugent, Tim C O; Bryson, Kevin; Jones, David T

    2013-07-01

    Here, we present the new UCL Bioinformatics Group's PSIPRED Protein Analysis Workbench. The Workbench unites all of our previously available analysis methods into a single web-based framework. The new web portal provides a greatly streamlined user interface with a number of new features to allow users to better explore their results. We offer a number of additional services to enable computationally scalable execution of our prediction methods; these include SOAP and XML-RPC web server access and new HADOOP packages. All software and services are available via the UCL Bioinformatics Group website at http://bioinf.cs.ucl.ac.uk/.

  10. ABS plastic RPCs

    Energy Technology Data Exchange (ETDEWEB)

    Ables, E.; Bionta, R.; Olson, H.; Ott, L.; Parker, E.; Wright, D.; Wuest, C

    1996-02-01

    After investigating a number of materials, we discovered that an ABS plastic doped with a conducting polymer performs well as the resistive electrode in a narrow gap RPC (resistive plate chamber). Operating in the streamer mode, we find efficiencies of 90-96% with low noise and low strip multiplicities. We have also studied a variety of operating gases and found that a mixture containing SF{sub 6}, a non-ozone depleting gas, argon and isobutane gives good streamer mode performance, even with isobutane concentrations of 20% or less.

  11. Static Validation of Security Protocols

    DEFF Research Database (Denmark)

    Bodei, Chiara; Buchholtz, Mikael; Degano, P.

    2005-01-01

    We methodically expand protocol narrations into terms of a process algebra in order to specify some of the checks that need to be made in a protocol. We then apply static analysis technology to develop an automatic validation procedure for protocols. Finally, we demonstrate that these techniques...... suffice to identify several authentication flaws in symmetric and asymmetric key protocols such as Needham-Schroeder symmetric key, Otway-Rees, Yahalom, Andrew secure RPC, Needham-Schroeder asymmetric key, and Beller-Chang-Yacobi MSR...

  12. NEW METHOD FOR ARRANGEMENT OF HIGH-ACCURATE DEVICES FOR MEASURING AND METERING LIQUID AND GAS FLOW RATE

    Directory of Open Access Journals (Sweden)

    I. E. Zuykov

    2009-01-01

    Full Text Available The paper presents results of a development and an industrial implementation of a new method for measuring liquid (water amount passing through measuring devices as a continuous flow by means of rotating blades. An algorithm of the device operation which serves as a basis for the method can be also used for designing devices for metering and control of gas consumption.The given method has its practical application in the electronic water meter developed at the «Elektronika» Plant of the RPC Integral.

  13. Programming Web services with Perl

    CERN Document Server

    Ray, Randy J

    2003-01-01

    Given Perl's natural fit for web applications development, it's no surprise that Perl is also a natural choice for web services development. It's the most popular web programming language, with strong implementations of both SOAP and XML-RPC, the leading ways to distribute applications using web services. But books on web services focus on writing these applications in Java or Visual Basic, leaving Perl programmers with few resources to get them started. Programming Web Services with Perl changes that, bringing Perl users all the information they need to create web services using their favori

  14. The HARP resistive plate chambers: Characteristics and physics performance

    CERN Document Server

    Ammosov, V; Chelkov, G; Dedovitch, D; Dydak, F; Elagin, A; Gapienko, V; Gostkin, M; Guskov, A; Koreshev, V; Kroumchtein, Z; Nefedov, Yu; Nikolaev, K; Semak, A; Sviridov, Yu; Usenko, E; Wotschack, J; Zaets, V; Zhemchugov, A

    2009-01-01

    The HARP resistive plate chamber (RPC) system was designed for time-of-flight measurement in the large-angle acceptance region of the HARP spectrometer. It comprised 46 four-gap glass RPCs covering an area of . The design of the RPCs, their operation, intrinsic properties, and system performance are described. The intrinsic time resolution of the RPCs is 127 ps leading to a system time-of-flight resolution of 175 ps. It is argued that gross differences between pion and proton timing in multi-gap timing RPCs, reported recently in the literature, do not exist.

  15. CMS muon system upgrade during LS1

    CERN Document Server

    Giannini, Leonardo

    2014-01-01

    The aim of this report is sharing my experience as a Summer Student at CERN. It is addressed mainly to future Summer Students and young people interested in science. In the introduction a brief description of the CMS muon system is given. The next two paragraphs provide more details about the two type of detectors I could work on and about my work as a Summer Student. The main activities I was involved in were Quality Control in RPC production and starting a DCS for the new GEM production facility. Finally an evaluation of the whole experience is made.

  16. ATLAS Tags Web Service calls Athena via Athenaeum Framework

    CERN Document Server

    Hrivnac, J; The ATLAS collaboration

    2011-01-01

    High Energy Physics experiments start using a Web Service style application to access functionality of their main frameworks. Those frameworks, however, are not ready to be executed in a standard Web Service environment as frameworks are too complex, monolithic and use non-standard and non-portable technologies. ATLAS Tag Browser is one of those Web Service. To provide the possibility to extract full ATLAS events from the standard Web Service, we need to access to full ATLAS offline framework - Athena. As Athena cannot run directly within any Web Service, the client server approach has been chosen. Web Service calls Athena remotely over XML-RPC connection using Athenaeum framework.

  17. Dicty_cDB: Contig-U03721-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Male Pupae Nasonia ... 42 3.6 1 ( FG542739 ) NADI-aaa55c03.b1 Rhodnius_prolixus_E...501 ) G825P59FG6.T0 Acorn worm normalized gastrula pExp... 42 3.6 1 ( EX473113 ) NADI-aaa17h07.b1 Rhodnius_prolix...us_EST_NADI_5th_i... 42 3.6 1 ( EX472902 ) NADI-aaa17h07.g1 Rhodnius_prolixu...4972 ) NADL-aaa18a05.b1 Rhodnius_prolixus_EST_NADL_RpcDN... 30 9.6 2 ( BX321879 ) Zebrafish DNA sequence fro

  18. Performance of a new generation RPCs for particle physics at colliders of the next generation

    CERN Document Server

    Paolozzi, L; The ATLAS collaboration

    2013-01-01

    The upgrade of present and future experiments in particle physics at high luminosity colliders will require a level one trigger of high selectivity and robustness in order to cope with the very heavy background levels. This selectivity requires detectors with very good space and time resolution operating at high rate. We present in this paper the latest developments of the RPC detectors concerning rate capability (up to 30kHz/cm2), space resolution (few hundred microns) and time resolution (few hundred pico s). We also show that this improvement required the development of a fast, low noise and large dynamics front end electronics and a better understanding of the detector physics.

  19. Relación entre la pureza radioquímica del 123i-ioflupano y la captación extracraneal (tiroidea y parotídea

    Directory of Open Access Journals (Sweden)

    Lucía Díaz Platas

    2015-12-01

    Full Text Available Objetivo: Estudiar el efecto de la pureza radioquímica (PR del 123I-Ioflupano, utilizado para realizar SPECT cerebral de transportadores de dopamina, sobre las imágenes obtenidas y evaluar la posible influencia de la extravasación durante su administración y del grado de afectación del paciente por el síndrome parkinsoniano sobre los resultados. Material y métodos: Se realizó un estudio prospectivo en 39 pacientes. La PR del 123I-Ioflupano se determinó mediante cromatografía en capa fina. Se delimitaron las regiones de interés (ROI en zona aproximada de cerebro, parótidas y región cervical, obteniéndose la media de cuentas en cada región y las ratios de actividad tiroides/cerebro (RTC y parótidas/cerebro (RPC. Se propuso un modelo de regresión lineal múltiple con predictores cuantitativos y categóricos. Resultados: El modelo mostró correlación entre la PR y la RTC modificada por la presencia de extravasación, fue estadísticamente significativo (p<0,001 y predijo el 42,31% de la variabilidad de la RTC. La correlación entre PR y RPC no se modificó por ninguna de las variables propuestas. El modelo fue estadísticamente significativo (p<0,0176 y predijo el 12,3% de la variabilidad del RPC. Conclusiones: La capacidad predictiva del modelo para explicar la variabilidad de la RTC es aceptable y explica la repercusión negativa de la extravasación. Sin embargo, la capacidad para explicar la variabilidad de la RPC es baja y debe ser atribuida a variables no estudiadas. Una PR baja y la extravasación durante la administración del radiofármaco se traduce en mayor actividad extracraneal e implica peor calidad de imagen y mayor irradiación tiroidea.

  20. Remote Data Transfer (RDT): An Interprocess Data Transfer Method for Distributed Environments

    Science.gov (United States)

    1992-05-01

    D’L-TR-3339 AD-A250 859 TECHNICAL REPORT BRL-TR-3339 r iAY2 0 I992i 51BR L 2 REMOTE DATA TRANSFER (RDT): AN INTERPROCESS DATA TRANSFER METHOD FOR...30 Sep 91 4. TITLE AND SUBTITLE S. FUNDING NUMBERS Remote Data Transfer (RdT): An Interprocess Data Transfer Method C-AHPCRC for Distributed...NUMBER OF PAGES 57 RPC: Remote Procedure Call; RdT: Remote Data Transfer ; 16. PRICE CODE XDR: External Data Representation, computer programs, software