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Sample records for high-performance h-mode plasmas

  1. High performance H-mode plasmas at densities above the Greenwald limit

    International Nuclear Information System (INIS)

    Mahdavi, M.A.; Osborne, T.H.; Leonard, A.W.

    2001-01-01

    Densities up to 40 percent above the Greenwald limit are reproducibly achieved in high confinement (H ITER89p =2) ELMing H-mode discharges. Simultaneous gas fueling and divertor pumping were used to obtain these results. Confinement of these discharges, similar to moderate density H-mode, is characterized by a stiff temperature profile, and therefore sensitive to the density profile. A particle transport model is presented that explains the roles of divertor pumping and geometry for access to high densities. Energy loss per ELM at high density is a factor of five lower than predictions of an earlier scaling, based on data from lower density discharges. (author)

  2. The quiescent H-mode regime for high performance edge localized mode-stable operation in future burning plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Garofalo, A. M., E-mail: garofalo@fusion.gat.com; Burrell, K. H.; Meneghini, O.; Osborne, T. H.; Paz-Soldan, C.; Smith, S. P.; Snyder, P. B.; Turnbull, A. D. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Eldon, D.; Grierson, B. A.; Solomon, W. M. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 08543-0451 (United States); Hanson, J. M. [Columbia University, 2960 Broadway, New York, New York 10027-6900 (United States); Holland, C. [University of California San Diego, 9500 Gilman Dr., La Jolla, California 92093-0417 (United States); Huijsmans, G. T. A.; Liu, F.; Loarte, A. [ITER Organization, Route de Vinon sur Verdon, 13067 St Paul Lez Durance (France); Zeng, L. [University of California Los Angeles, P.O. Box 957099, Los Angeles, California 90095-7099 (United States)

    2015-05-15

    For the first time, DIII-D experiments have achieved stationary quiescent H-mode (QH-mode) operation for many energy confinement times at simultaneous ITER-relevant values of beta, confinement, and safety factor, in an ITER-like shape. QH-mode provides excellent energy confinement, even at very low plasma rotation, while operating without edge localized modes (ELMs) and with strong impurity transport via the benign edge harmonic oscillation (EHO). By tailoring the plasma shape to improve the edge stability, the QH-mode operating space has also been extended to densities exceeding 80% of the Greenwald limit, overcoming the long-standing low-density limit of QH-mode operation. In the theory, the density range over which the plasma encounters the kink-peeling boundary widens as the plasma cross-section shaping is increased, thus increasing the QH-mode density threshold. The DIII-D results are in excellent agreement with these predictions, and nonlinear magnetohydrodynamic analysis of reconstructed QH-mode equilibria shows unstable low n kink-peeling modes growing to a saturated level, consistent with the theoretical picture of the EHO. Furthermore, high density operation in the QH-mode regime has opened a path to a new, previously predicted region of parameter space, named “Super H-mode” because it is characterized by very high pedestals that can be more than a factor of two above the peeling-ballooning stability limit for similar ELMing H-mode discharges at the same density.

  3. 'Snowflake' H Mode in a Tokamak Plasma

    International Nuclear Information System (INIS)

    Piras, F.; Coda, S.; Duval, B. P.; Labit, B.; Marki, J.; Moret, J.-M.; Pitzschke, A.; Sauter, O.; Medvedev, S. Yu.

    2010-01-01

    An edge-localized mode (ELM) H-mode regime, supported by electron cyclotron heating, has been successfully established in a 'snowflake' (second-order null) divertor configuration for the first time in the TCV tokamak. This regime exhibits 2 to 3 times lower ELM frequency and 20%-30% increased normalized ELM energy (ΔW ELM /W p ) compared to an identically shaped, conventional single-null diverted H mode. Enhanced stability of mid- to high-toroidal-mode-number ideal modes is consistent with the different snowflake ELM phenomenology. The capability of the snowflake to redistribute the edge power on the additional strike points has been confirmed experimentally.

  4. Theory of anomalous transport in H-mode plasmas

    International Nuclear Information System (INIS)

    Itoh, S.; Itoh, K.; Fukuyama, A.; Yagi, M.

    1993-05-01

    Theory of the anomalous transport is developed, and the unified formula for the L- and H-mode plasmas is presented. The self-sustained ballooning-mode turbulence is solved in the presence of the inhomogeneous radial electric field, E r . Reductions in transport coefficients and the amplitude and decorrelation length of fluctuations due to E r ' are quantitatively analyzed. Combined with the E r -bifurcation model, the thickness of the transport barrier is simultaneously determined. (author)

  5. H-mode development in TEXT-U limiter plasmas

    International Nuclear Information System (INIS)

    Roberts, D.R.; Bravenec, R.V.; Bengtson, R.D.

    1996-01-01

    H-mode transitions in TEXT-U limiter plasmas have been observed at q a ∼ 3 and I p ∼ 250 kA (P OH ∼ 300 kW) with at least 300 kW of central electron-cyclotron heating (ECH). These are dithering transitions which are induced by sawtooth crashes and display the typical signatures of H-modes (D α drop, spontaneous density increase, evidence of a transport barrier). However, they show only a slight improvement over L-mode energy confinement. The vessel walls are boronized and conditioned prior to experiments to achieve low-impurity influx and particle recycling. Discharges which undergo transitions are fuelled almost entirely on residual recycling. Transitions are observed when limited on a toroidally localized top or bottom limiter and, more often, when the limiter surface is 'fresh', which is achieved by alternating between top and bottom limiters on successive shots. No strong dependence upon the distance from the low-field-side limiter has been found. Transitions are not yet observed when limited on the high-field-side wall tiles or in the case of TEXT-U diverted configurations. Preliminary measurements with the 2 MeV heavy-ion beam probe (HIBP) (in the core) and Langmuir probes (in the edge) indicate that the plasma potential drops outside the q = 1 radius while only small changes are observed in the density fluctuations level. (author)

  6. Transport in JET high performance plasmas

    International Nuclear Information System (INIS)

    2001-01-01

    Two type of high performance scenarios have been produced in JET during DTE1 campaign. One of them is the well known and extensively used in the past ELM-free hot ion H-mode scenario which has two distinct regions- plasma core and the edge transport barrier. The results obtained during DTE-1 campaign with D, DT and pure T plasmas confirms our previous conclusion that the core transport scales as a gyroBohm in the inner half of plasma volume, recovers its Bohm nature closer to the separatrix and behaves as ion neoclassical in the transport barrier. Measurements on the top of the barrier suggest that the width of the barrier is dependent upon isotope and moreover suggest that fast ions play a key role. The other high performance scenario is a relatively recently developed Optimised Shear Scenario with small or slightly negative magnetic shear in plasma core. Different mechanisms of Internal Transport Barrier (ITB) formation have been tested by predictive modelling and the results are compared with experimentally observed phenomena. The experimentally observed non-penetration of the heavy impurities through the strong ITB which contradicts to a prediction of the conventional neo-classical theory is discussed. (author)

  7. Transport in JET high performance plasmas

    International Nuclear Information System (INIS)

    1999-01-01

    Two type of high performance scenarios have been produced in JET during DTE1 campaign. One of them is the well known and extensively used in the past ELM-free hot ion H-mode scenario which has two distinct regions- plasma core and the edge transport barrier. The results obtained during DTE-1 campaign with D, DT and pure T plasmas confirms our previous conclusion that the core transport scales as a gyroBohm in the inner half of plasma volume, recovers its Bohm nature closer to the separatrix and behaves as ion neoclassical in the transport barrier. Measurements on the top of the barrier suggest that the width of the barrier is dependent upon isotope and moreover suggest that fast ions play a key role. The other high performance scenario is a relatively recently developed Optimised Shear Scenario with small or slightly negative magnetic shear in plasma core. Different mechanisms of Internal Transport Barrier (ITB) formation have been tested by predictive modelling and the results are compared with experimentally observed phenomena. The experimentally observed non-penetration of the heavy impurities through the strong ITB which contradicts to a prediction of the conventional neo-classical theory is discussed. (author)

  8. Particle transport in JET and TCV-H mode plasmas

    International Nuclear Information System (INIS)

    Maslov, M.

    2009-10-01

    Understanding particle transport physics is of great importance for magnetically confined plasma devices and for the development of thermonuclear fusion power for energy production. From the beginnings of fusion research, more than half a century ago, the problem of heat transport in tokamaks attracted the attention of researchers, but the particle transport phenomena were largely neglected until fairly recently. As tokamak physics advanced to its present level, the physics community realized that there are many hurdles to the development of fusion power beyond the energy confinement. Particle transport is one of the outstanding issues. The aim of this thesis work is to study the anomalous (turbulence driven) particle transport in tokamaks on the basis of experiments on two different devices: JET (Joint European Torus) and TCV (Tokamak à Configuration Variable). In particular the physics of particle inward convection (pinch), which causes formation of peaked density profiles, is addressed in this work. Density profile peaking has a direct, favorable effect on fusion power in a reactor, we therefore also propose an extrapolation to the international experimental reactor ITER, which is currently under construction. To complete the thesis research, a comprehensive experimental database was created on the basis of data collected on JET and TCV during the duration of the thesis. Improvements of the density profile measurements techniques and careful analysis of the experimental data allowed us to derive the dependencies of density profile shape on the relevant plasma parameters. These improved techniques also allowed us to dispel any doubts that had been voiced about previous results. The major conclusions from previous work on JET and other tokamaks were generally confirmed, with some minor supplements. The main novelty of the thesis resides in systematic tests of the predictions of linear gyrokinetic simulations of the ITG (Ion Temperature Gradient) mode against the

  9. Comparison of fusion alpha performance in JET advanced scenario and H-mode plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Asunta, O; Kurki-Suonio, T; Tala, T; Sipilae, S; Salomaa, R [JET-EFDA, Culham Science Centre, OX14 3DB, Abingdon (United Kingdom)], E-mail: Otto.Asunta@tkk.fi

    2008-12-15

    Currently, plasmas with internal transport barriers (ITBs) appear the most likely candidates for steady-state scenarios for future fusion reactors. In such plasmas, the broad hot and dense region in the plasma core leads to high fusion gain, while the cool edge protects the integrity of the first wall. Economically desirable large bootstrap current fraction and low inductive current drive may, however, lead to degraded fast ion confinement. In this work the confinement and heating profile of fusion alphas were compared between H-mode and ITB plasmas in realistic JET geometry. The work was carried out using the Monte Carlo-based guiding-center-following code ASCOT. For the same plasma current, the ITB discharges were found to produce four to eight times more fusion power than a comparable ELMy H-mode discharge. Unfortunately, also the alpha particle losses were larger ({approx}16%) compared with the H-mode discharge (7%). In the H-mode discharges, alpha power was deposited to the plasma symmetrically around the magnetic axis, whereas in the current-hole discharge, the power was spread out to a larger volume in the plasma center. This was due to wider particle orbits, and the magnetic structure allowing for a broader hot region in the centre.

  10. Plasma current dependence of the edge pedestal height in JET ELM-free H-modes

    International Nuclear Information System (INIS)

    Nave, M.F.F; Lomas, P.; Gowers, C.; Guo, H.; Hawkes, N.; Huysmans, G.T.A.; Jones, T.; Parail, V.V.; Rimini, F.; Schunke, B.

    2000-01-01

    Some models for the suppression of turbulence in the L to H transition, suggest that the width of the H-mode edge barrier is either proportional or is of the order of the thermal or the fast-ion poloidal Larmor radius. This would require that the width of the edge barrier should depend on the plasma current. This dependence has been clearly verified at JET in experiments designed to control the edge MHD stability of ELM-free hot-ion H-mode plasmas. The effects of isotopic mass and the applicability of several edge barrier models to the hot-ion H-mode plasmas were analysed in (Guo H Y et al 2000 Edge transport barrier in JET hot-ion H-modes Nucl. Fusion 40 69) using a large database containing both deuterium-only and deuterium-tritium plasmas. This database has now been enlarged to include discharges from a plasma shape scan, allowing one to study the dependence of the pedestal height on the edge shear. In addition, the range of plasma currents was extended up to 6 MA. It is shown that the edge data are best described by a model where the edge barrier width is determined by the fast ions weighted towards the components with largest poloidal Larmor radii. However, it is not possible to conclusively eliminate the thermal ion model. (author)

  11. The influence of gas pressure on E↔H mode transition in argon inductively coupled plasmas

    Science.gov (United States)

    Zhang, Xiao; Zhang, Zhong-kai; Cao, Jin-xiang; Liu, Yu; Yu, Peng-cheng

    2018-03-01

    Considering the gas pressure and radio frequency power change, the mode transition of E↔H were investigated in inductively coupled plasmas. It can be found that the transition power has almost the same trend decreasing with gas pressure, whether it is in H mode or E mode. However, the transition density increases slowly with gas pressure from E to H mode. The transition points of E to H mode can be understood by the propagation of electromagnetic wave in the plasma, while the H to E should be illustrated by the electric field strength. Moreover, the electron density, increasing with the pressure and power, can be attributed to the multiple ionization, which changes the energy loss per electron-ion pair created. In addition, the optical emission characteristics in E and H mode is also shown. The line ratio of I750.4 and I811.5, taken as a proxy of the density of metastable state atoms, was used to illustrate the hysteresis. The 750.4 nm line intensity, which has almost the same trend with the 811.5 nm line intensity in H mode, both of them increases with power but decreases with gas pressure. The line ratio of 811.5/750.4 has a different change rule in E mode and H mode, and at the transition point of H to E, it can be one significant factor that results in the hysteresis as the gas pressure change. And compared with the 811.5 nm intensity, it seems like a similar change rule with RF power in E mode. Moreover, some emitted lines with lower rate constants don't turn up in E mode, while can be seen in H mode because the excited state atom density increasing with the electron density.

  12. New Edge Coherent Mode Providing Continuous Transport in Long Pulse H-mode Plasmas

    DEFF Research Database (Denmark)

    Wang, H.Q.; Xu, G.S.; Wan, B.N.

    2014-01-01

    An electrostatic coherent mode near the electron diamagnetic frequency (20–90 kHz) is observed in the steep-gradient pedestal region of long pulse H-mode plasmas in the Experimental Advanced Super-conducting Tokamak, using a newly developed dual gas-puff-imaging system and diamond-coated reciproc...

  13. MHD-activity in ohmic, diverted and limited H-mode plasmas in TCV

    International Nuclear Information System (INIS)

    Pochelon, A.; Anton, M.; Buehlmann, F.; Dutch, M.J.; Duval, B.P.; Hirt, A.; Hofmann, F.; Joye, B.; Lister, J.B.; Llobet, X.; Martin, Y.; Moret, J.M.; Nieswand, C.; Pietrzyk, A.Z.; Tonetti, G.; Weisen, H.

    1994-01-01

    During its first year of operation the TCV tokamak has produced a variety of plasma configurations with currents in the range 150 to 800 kA and elongations in the range of 1.0 to 2.05. Ohmic H-modes have been obtained in diverted discharges and discharges limited on the graphite tiles inner wall. After boronisation in May 1994 H-modes with line average densities up to 1.7x10 20 m -3 , corresponding to a Murakami parameter of 10, were obtained. (author) 5 figs., 2 refs

  14. Observation of inverse hysteresis in the E to H mode transitions in inductively coupled plasmas

    International Nuclear Information System (INIS)

    Lee, Min-Hyong; Chung, Chin-Wook

    2010-01-01

    An inverse hysteresis is observed during the E mode to H mode transition in low pressure argon inductively coupled plasmas. The transition is accompanied by an evolution of electron energy distribution from the bi-Maxwellian to the Maxwellian distribution. The mechanism of this inversion is not clear. However, we think that the bi-Maxwellian electron energy distribution in E mode, where the proportion of high energy electron is much higher than the Maxwellian distribution, would be one of the reasons for the observed inverse hysteresis. As the gas pressure increases, the inverse hysteresis disappears and the E to H mode transition follows the scenario of usual hysteresis.

  15. Comparison of L- and H-mode plasma edge fluctuations in MAST

    International Nuclear Information System (INIS)

    Dudson, B D; Dendy, R O; Kirk, A; Meyer, H; Counsell, G F

    2005-01-01

    Edge turbulence measurements from a reciprocating Langmuir probe in MAST are presented. A comparison of the range/standard deviation (R/S), growth of range, first moment and differencing and rescaling methods for calculating the Hurst exponent is made. The differencing and rescaling method is found to be the most useful for identifying scaling over long time-periods. A comparison is made between L-mode, dithering H-mode and H-mode plasma edge turbulence and evidence for self-similarity is found. Tests are performed and it is demonstrated that the results are due to properties of the data, and are not artefacts of the methods. A comparison of Hurst exponent methods with the autocorrelation function and power spectrum is used to demonstrate the presence of long-time correlation in L-mode data, and the absence of long-time correlation in the case of dithering H-mode

  16. Plasma current dependence of the edge pedestal height in JET ELM-free H-modes

    International Nuclear Information System (INIS)

    Nave, M.; Lomas, P.; Gowers, C.

    2000-01-01

    Models for the suppression of turbulence in the L to H transition, suggest that the width of the H-mode edge barrier is either proportional or is of the order of the ion poloidal Larmor radius. This would require that the width of the edge barrier should depend on the plasma current. This dependence has been clearly verified at JET in experiments designed to control the edge MHD stability of ELM-free hot-ion H-mode plasmas. The effects of isotopic mass and the applicability of several edge barrier models to the hot-ion H-mode plasmas were analysed in using a large database containing both Deuterium-only (DD) and Deuterium-Tritium (DT) plasmas. This database has now been enlarged to include discharges from a plasma shape scan, allowing to study the dependence of the pedestal height on the edge shear. In addition the range of plasma currents was extended up to 6 MA. It is shown that the edge data is best described by a model where the edge barrier width is determined by the fast ions weighted towards the components with largest poloidal Larmor radii. However, it is not possible to eliminate conclusively the thermal ion model. (author)

  17. New fluctuation phenomena in the H-mode regime of PDX tokamak plasmas

    International Nuclear Information System (INIS)

    Slusher, R.E.; Surko, C.M.; Valley, J.F.; Crowley, T.; Mazzucato, E.; McGuire, K.

    1984-05-01

    A new kind of quasi-coherent fluctuation is observed near the edge of plasmas in the PDX tokamak during H-mode operation. (The H-mode occurs in neutral beam heated divertor plasmas and is characterized by improved energy containment as well as large density and temperature gradients near the plasma edge.) These fluctuations are evidenced as VUV and density fluctuation bursts at well-defined frequencies (Δω/ω less than or equal to 0.1) in the frequency range between 50 and 180 kHz. They affect the edge temperature-density product, and therefore they may be important for understanding the relationship between the large edge density and temperature gradients and the improved energy confinement

  18. Energy confinement and transport of H-mode plasmas in tokamak

    International Nuclear Information System (INIS)

    Urano, Hajime

    2005-02-01

    A characteristic feature of the high-confinement (H-mode) regime is the formation of a transport barrier near the plasma edge, where steepening of the density and temperature gradients is observed. The H-mode is expected to be a standard operation mode in a next-step fusion experimental reactor, called ITER-the International Thermonuclear Experimental Reactor. However, energy confinement in the H-mode has been observed to degrade with increasing density. This is a critical constraint for the operation domain in the ITER. Investigation of the main cause of confinement degradation is an urgent issue in the ITER Physics Research and Development Activity. A key element for solving this problem is investigation of the energy confinement and transport properties of H-mode plasmas. However, the influence of the plasma boundary characterized by the transport barrier in H-modes on the energy transport of the plasma core has not been examined sufficiently in tokamak research. The aim of this study is therefore to investigate the energy confinement properties of H-modes in a variety of density, plasma shape, seed impurity concentration, and conductive heat flux in the plasma core using the experimental results obtained in the JT-60U tokamak of Japan Atomic Energy Research Institute. Comparison of the H-mode confinement properties with those of other tokamaks using an international multi-machine database for extrapolation to the next step device was also one of the main subjects in this study. Density dependence of the energy confinement properties has been examined systematically by separating the thermal stored energy into the H-mode pedestal component determined by MHD stability called the Edge Localized Modes (ELMs) and the core component governed by gyro-Bohm-like transport. It has been found that the pedestal pressure imposed by the destabilization of ELM activities led to a reduction in the pedestal temperature with increasing density. The core temperature for each

  19. ELM triggering conditions for the integrated modeling of H-mode plasmas

    International Nuclear Information System (INIS)

    Pankin, A.Y.; Schnack, D.D.; Bateman, G.; Kritz, A.H.; Brennan, D.P.; Snyder, P.B.; Voitsekhovitch, I.; Kruger, S.; Janeschitz, G.; Onjun, T.; Pacher, G.W.; Pacher, H.D.

    2005-01-01

    Recent advances in the integrated modeling of ELMy H-mode plasmas are presented. A new model for the H-mode pedestal and for the triggering of ELMs predicts the height, width, and shape of the H-mode pedestal and the frequency and width of ELMs. The model for the pedestal and ELMs is used in the ASTRA integrated transport code to follow the time evolution of tokamak discharges from L-mode through the transition from L-mode to H-mode, with the formation of the H-mode pedestal, and, subsequently, to the triggering of ELMs. Turbulence driven by the ion temperature gradient mode, resistive ballooning mode, trapped electron mode, and electron temperature gradient mode contributes to the anomalous thermal transport at the plasma edge in this model. Formation of the pedestal and the L-H transition is the direct result of E(vector) r x B(vector) flow shear suppression of anomalous transport. The periodic ELM crashes are triggered by MHD instabilities. Two mechanisms for triggering ELMs are considered: ELMs are triggered by ballooning modes if the pressure gradient exceeds the ballooning threshold or by peeling modes if the edge current density exceeds the peeling mode threshold. The BALOO, DCON, and ELITE ideal MHD stability codes are used to derive a new parametric expression for the peeling-ballooning threshold. The new dependence for the peeling-ballooning threshold is implemented in the ASTRA transport code. Results of integrated modeling of DIII-D like discharges are presented and compared with experimental observations. The results from the ideal MHD stability codes are compared with results from the resistive MHD stability code NIMROD. (author)

  20. Tungsten transport in JET H-mode plasmas in hybrid scenario, experimental observations and modelling

    Czech Academy of Sciences Publication Activity Database

    Angioni, C.; Mantica, P.; Pütterich, T.; Valisa, M.; Baruzzo, M.; Belli, A.E.; Belo, P.; Casson, F.J.; Challis, C.; Drewelow, P.; Giroud, C.; Hawkes, N.; Hender, T.C.; Hobirk, J.; Koskela, T.; Lauro Taroni, L.; Maggi, C.F.; Mlynář, Jan; Odstrčil, T.; Reinke, M.L.; Romanelli, M.

    2014-01-01

    Roč. 54, č. 8 (2014), 083028-083028 ISSN 0029-5515 Institutional support: RVO:61389021 Keywords : heavy impurity transport * H-mode hybrid scenario * neoclassical and turbulent transport Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.062, year: 2014 http://iopscience.iop.org/0029-5515/54/8/083028/pdf/0029-5515_54_8_083028.pdf

  1. Observation of internal transport barrier in ELMy H-mode plasmas on the EAST tokamak

    Science.gov (United States)

    Yang, Y.; Gao, X.; Liu, H. Q.; Li, G. Q.; Zhang, T.; Zeng, L.; Liu, Y. K.; Wu, M. Q.; Kong, D. F.; Ming, T. F.; Han, X.; Wang, Y. M.; Zang, Q.; Lyu, B.; Li, Y. Y.; Duan, Y. M.; Zhong, F. B.; Li, K.; Xu, L. Q.; Gong, X. Z.; Sun, Y. W.; Qian, J. P.; Ding, B. J.; Liu, Z. X.; Liu, F. K.; Hu, C. D.; Xiang, N.; Liang, Y. F.; Zhang, X. D.; Wan, B. N.; Li, J. G.; Wan, Y. X.; EAST Team

    2017-08-01

    The internal transport barrier (ITB) has been obtained in ELMy H-mode plasmas by neutron beam injection and lower hybrid wave heating on the Experimental Advanced Superconducting Tokamak (EAST). The ITB structure has been observed in profiles of ion temperature, electron temperature, and electron density within ρ safety factor q(0) ˜ 1. Transport coefficients are calculated by particle balance and power balance analysis, showing an obvious reduction after the ITB formation.

  2. Local Physics Basis of Confinement Degradation in JET ELMy H-Mode Plasmas and Implications for Tokamak Reactors

    International Nuclear Information System (INIS)

    Budny, R.V.; Alper, B.; Borba, D.; Cordey, J.G.; Ernst, D.R.; Gowers, C.

    2001-01-01

    First results of gyrokinetic analysis of JET [Joint European Torus] ELMy [Edge Localized Modes] H-mode [high-confinement modes] plasmas are presented. ELMy H-mode plasmas form the basis of conservative performance predictions for tokamak reactors of the size of ITER [International Thermonuclear Experimental Reactor]. Relatively high performance for long duration has been achieved and the scaling appears to be favorable. It will be necessary to sustain low Z(subscript eff) and high density for high fusion yield. This paper studies the degradation in confinement and increase in the anomalous heat transport observed in two JET plasmas: one with an intense gas puff and the other with a spontaneous transition between Type I to III ELMs at the heating power threshold. Linear gyrokinetic analysis gives the growth rate, gamma(subscript lin) of the fastest growing modes. The flow-shearing rate omega(subscript ExB) and gamma(subscript lin) are large near the top of the pedestal. Their ratio decreases approximately when the confinement degrades and the transport increases. This suggests that tokamak reactors may require intense toroidal or poloidal torque input to maintain sufficiently high |gamma(subscript ExB)|/gamma(subscript lin) near the top of the pedestal for high confinement

  3. Confinement improvement in H-mode-like plasmas in helical systems

    International Nuclear Information System (INIS)

    Itoh, K.; Sanuki, H.; Itoh, S.; Fukuyama, A.; Yagi, M.

    1993-06-01

    The reduction of the anomalous transport due to the inhomogeneous radial electric field is theoretically studied for toroidal helical plasmas. The self-sustained interchange-mode turbulence is analysed for the system with magnetic shear and magnetic hill. For the system with magnetic well like conventional stellarators, the ballooning mode turbulence is studied. Influence of the radial electric field inhomogeneity on the transport coefficients and fluctuations are quantitatively shown. Unified theory of the transport coefficients in the L-mode and H-mode-like plasmas are presented. (author)

  4. Quiescent H-mode plasmas with strong edge rotation in the cocurrent direction.

    Science.gov (United States)

    Burrell, K H; Osborne, T H; Snyder, P B; West, W P; Fenstermacher, M E; Groebner, R J; Gohil, P; Leonard, A W; Solomon, W M

    2009-04-17

    For the first time in any tokamak, quiescent H-mode (QH-mode) plasmas have been created with strong edge rotation in the direction of the plasma current. This confirms the theoretical prediction that the QH mode should exist with either sign of the edge rotation provided the magnitude of the shear in the edge rotation is sufficiently large and demonstrates that counterinjection and counteredge rotation are not essential for the QH mode. Accordingly, the present work demonstrates a substantial broadening of the QH-mode operating space and represents a significant confirmation of the theory.

  5. Coupling of an ICRF compact loop antenna to H-mode plasmas in DIII-D

    International Nuclear Information System (INIS)

    Mayberry, M.J.; Baity, F.W.; Hoffman, D.J.; Luxon, J.L.; Owens, T.L.; Prater, R.

    1987-01-01

    Low power coupling tests have been carried out with a prototype ICRF compact loop antenna on the DIII-D tokamak. During neutral-beam-heated L-mode discharges the antenna loading is typically R≅1-2Ω for an rf frequency of 32 MHz (B/sub T/ = 21 kG, ω = 2Ω/sub D/(0)). When a transition into the H-mode regime of improved confinement occurs, the loading drops to R≅0.5-1.0Ω. During ELMs, transient increases in loading up to several Ohms are observed. The apparent sensitivity of ICRF antenna coupling to changes in the edge plasma profiles associated with the H-mode regime could have important implications for the design of future high power systems

  6. Effect of low density H-mode operation on edge and divertor plasma parameters

    International Nuclear Information System (INIS)

    Maingi, R.; Mioduszewski, P.K.; Cuthbertson, J.W.

    1994-07-01

    We present a study of the impact of H-mode operation at low density on divertor plasma parameters on the DIII-D tokamak. The line-average density in H-mode was scanned by variation of the particle exhaust rate, using the recently installed divertor cryo-condensation pump. The maximum decrease (50%) in line-average electron density was accompanied by a factor of 2 increase in the edge electron temperature, and 10% and 20% reductions in the measured core and divertor radiated power, respectively. The measured total power to the inboard divertor target increased by a factor of 3, with the major contribution coming from a factor of 5 increase in the peak heat flux very close to the inner strike point. The measured increase in power at the inboard divertor target was approximately equal to the measured decrease in core and divertor radiation

  7. Pedestal Temperature Model for Type III ELMy H-mode Plasma

    International Nuclear Information System (INIS)

    Buangam, W.; Suwanna, S.; Onjun, T.; Poolyarat, N.; Picha, R.; Singhsomroje, W.

    2009-07-01

    Full text: It is widely known that the improved performance of H-mode plasma results mainly from a formation of the pedestal, which is a narrow region of strong pressure gradient near the edge of plasma. A predictive capability for the conditions at the top of the pedestal is important, especially for predictive simulations of future experiments. New models for predicting the temperature values at the top of the pedestal for type III ELMy H-mode plasma are developed by using two different approaches: a theory-based approaches and an empirical approach. For a theory-based approach, a model is developed based on the calculation of thermal energy in the pedestal region and on accepted scaling laws of energy confinement time. For an empirical model, a scaling law for pedestal temperature in terms of plasma controlled parameters, such as plasma current, magnetic field, heating power, is deduced from experimental data. Predictions from these models are compared with experimental data from the Pedestal International Database. Statistical quantities, such as Root-Mean Square Error (RMSE) and offset values, are computed to quantify the predictive capability of the models. It is found that the theory-based model predicts the pedestal temperature values moderately well yielding RMSE between 30% and 40%. The IPB98(y,3) scaling law yields with best agreement with RMSE of 30.4%. The empirical model predicts the pedestal temperature value with better agreement, yield RMSE of 25.9%

  8. Edge density profiles in high-performance JET plasmas

    International Nuclear Information System (INIS)

    Summers, D.D.R.; Viaccoz, B.; Vince, J.

    1997-01-01

    Detailed electron density profiles of the scrape-off layer in high-performance JET plasmas (plasma current, I p nbi ∝17 MW) have been measured by means of a lithium beam diagnostic system featuring high spatial resolution [Kadota (1978)[. Measurements were taken over a period of several seconds, allowing examination of the evolution of the edge profile at a location upstream from the divertor target. The data clearly show the effects of the H-mode transition - an increase in density near the plasma separatrix and a reduction in density scrape-off length. The profiles obtained under various plasma conditions are compared firstly with data from other diagnostics, located elsewhere in the vessel, and also with the predictions of an 'onion-skin' model (DIVIMP), which used, as initial parameters, data from an array of probes located in the divertor target. (orig.)

  9. ELM triggering conditions for the integrated modeling of H-mode plasmas

    International Nuclear Information System (INIS)

    Pankin, A.Y.; Schnack, D.D.; Bateman, G.; Kritz, A.H.; Brennan, D.P.; Snyder, P.B.; Voitsekhovitch, I.; Kruger, S.; Janeschitz, G.; Onjun, T.; Pacher, G.W.; Pacher, H.D.

    2004-01-01

    Recent advances in the integrated modeling of ELMy (edge localized mode) H-mode plasmas are presented. A model for the H-mode pedestal and for the triggering of ELMs predicts the height, width, and shape of the H-mode pedestal and the frequency and width of ELMs. Formation of the pedestal and the L-H transition is the direct result of E r x B flow shear suppression of anomalous transport. The periodic ELM crashes are triggered by either the ballooning or peeling MHD instabilities. The BALOO, DCON, and ELITE ideal MHD stability codes are used to derive a new parametric expression for the peeling-ballooning threshold. The new dependence for the peeling-ballooning threshold is implemented in the ASTRA transport code. Results of integrated modeling of DIII-D like discharges are presented and compared with experimental observations. The results from the ideal MHD stability codes are compared with results from the resistive MHD stability code NIMROD. (authors)

  10. Rotation characteristics of main ions and impurity ions in H-mode tokamak plasma

    International Nuclear Information System (INIS)

    Kim, J.; Burrell, K.H.; Gohil, P.; Groebner, R.J.; Kim, Y.; St. John, H.E.; Seraydarian, R.P.; Wade, M.R.

    1994-01-01

    Poloidal and toroidal rotation of the main ions (He 2+ ) and the impurity ions (C 6+ and B 5+ ) in H-mode helium plasmas have been measured via charge exchange recombination spectroscopy in the DIII-D tokamak. It was discovered that the main ion poloidal rotation is in the ion diamagnetic drift direction while the impurity ion rotation is in the electron diamagnetic drift direction, in qualitative agreement with the neoclassical theory. The deduced radial electric field in the edge is of the same negative-well shape regardless of which ion species is used, validating the fundamental nature of the electric field in L-H transition phenomenology

  11. Accounting of the Power Balance for Neutral-beam heated H-Mode Plasmas in NSTX

    International Nuclear Information System (INIS)

    Paul, S.F.; Maingi, R.; Soukhanovskii, V.; Kaye, S.M.; Kugel, H.

    2004-01-01

    A survey of the dependence of power balance on input power, shape, and plasma current was conducted for neutral-beam-heated plasmas in the National Spherical Torus Experiment (NSTX). Measurements of heat to the divertor strike plates and divertor and core radiation were taken over a wide range of plasma conditions. The different conditions were obtained by inducing a L-mode to H-mode transition, changing the divertor configuration [lower single null (LSN) vs. double-null (DND)] and conducting a NBI power scan in H-mode. 60-70% of the net input power is accounted for in the LSN discharges with 20% of power lost as fast ions, 30-45% incident on the divertor plates, up to 10% radiated in the core, and about 12% radiated in the divertor. In contrast, the power accountability in DND is 85-90%. A comparison of DND and LSN data show that the remaining power in the LSN is likely to be directed to the upper divertor

  12. Methane penetration in DIII-D ELMing H-mode plasmas

    International Nuclear Information System (INIS)

    West, W.P.; Lasnier, C.J.; Whyte, D.G.; Isler, R.C.; Evans, T.E.; Jackson, G.L.; Rudakov, D.; Wade, M.R.; Strachan, J.

    2003-01-01

    Carbon penetration into the core plasma during midplane and divertor methane puffing has been measured for DIII-D ELMing H-mode plasmas. The methane puffs are adjusted to a measurable signal, but global plasma parameters are only weakly affected (line average density, e > increases by E , drops by 6+ density profiles in the core measured as a function of time using charge exchange recombination spectroscopy. The methane penetration factor is defined as the difference in the core content with the puff on and puff off, divided by the carbon confinement time and the methane puffing rate. In ELMing H-mode discharges with ion ∇B drift direction into the X-point, increasing the line averaged density from 5 to 8x10 19 m -3 dropped the penetration factor from 6.6% to 4.6% for main chamber puffing. The penetration factor for divertor puffing was below the detection limit (<1%). Changing the ion ∇B drift to away from the X-point decreased the penetration factor by more than a factor of five for main chamber puffing

  13. Particle and power deposition on divertor targets in EAST H-mode plasmas

    International Nuclear Information System (INIS)

    Wang, L.; Xu, G.S.; Guo, H.Y.; Chen, R.; Ding, S.; Gan, K.F.; Gao, X.; Gong, X.Z.; Jiang, M.; Liu, P.; Liu, S.C.; Luo, G.N.; Ming, T.F.; Wan, B.N.; Wang, D.S.; Wang, F.M.; Wang, H.Q.; Wu, Z.W.; Yan, N.; Zhang, L.

    2012-01-01

    The effects of edge-localized modes (ELMs) on divertor particle and heat fluxes were investigated for the first time in the Experimental Advanced Superconducting Tokamak (EAST). The experiments were carried out with both double null and lower single null divertor configurations, and comparisons were made between the H-mode plasmas with lower hybrid current drive (LHCD) and those with combined ion cyclotron resonance heating (ICRH). The particle and heat flux profiles between and during ELMs were obtained from Langmuir triple-probe arrays embedded in the divertor target plates. And isolated ELMs were chosen for analysis in order to reduce the uncertainty resulting from the influence of fast electrons on Langmuir triple-probe evaluation during ELMs. The power deposition obtained from Langmuir triple probes was consistent with that from the divertor infra-red camera during an ELM-free period. It was demonstrated that ELM-induced radial transport predominantly originated from the low-field side region, in good agreement with the ballooning-like transport model and experimental results of other tokamaks. ELMs significantly enhanced the divertor particle and heat fluxes, without significantly broadening the SOL width and plasma-wetted area on the divertor target in both LHCD and LHCD + ICRH H-modes, thus posing a great challenge for the next-step high-power, long-pulse operation in EAST. Increasing the divertor-wetted area was also observed to reduce the peak heat flux and particle recycling at the divertor target, hence facilitating long-pulse H-mode operation. The particle and heat flux profiles during ELMs appeared to exhibit multiple peak structures, and were analysed in terms of the behaviour of ELM filaments and the flux tubes induced by modified magnetic topology during ELMs. (paper)

  14. Predictive modelling of edge transport phenomena in ELMy H-mode tokamak fusion plasmas

    International Nuclear Information System (INIS)

    Loennroth, J.-S.

    2009-01-01

    This thesis discusses a range of work dealing with edge plasma transport in magnetically confined fusion plasmas by means of predictive transport modelling, a technique in which qualitative predictions and explanations are sought by running transport codes equipped with models for plasma transport and other relevant phenomena. The focus is on high confinement mode (H-mode) tokamak plasmas, which feature improved performance thanks to the formation of an edge transport barrier. H-mode plasmas are generally characterized by the occurrence of edge localized modes (ELMs), periodic eruptions of particles and energy, which limit confinement and may turn out to be seriously damaging in future tokamaks. The thesis introduces schemes and models for qualitative study of the ELM phenomenon in predictive transport modelling. It aims to shed new light on the dynamics of ELMs using these models. It tries to explain various experimental observations related to the performance and ELM-behaviour of H-mode plasmas. Finally, it also tries to establish more generally the potential effects of ripple-induced thermal ion losses on H-mode plasma performance and ELMs. It is demonstrated that the proposed ELM modelling schemes can qualitatively reproduce the experimental dynamics of a number of ELM regimes. Using a theory-motivated ELM model based on a linear instability model, the dynamics of combined ballooning-peeling mode ELMs is studied. It is shown that the ELMs are most often triggered by a ballooning mode instability, which renders the plasma peeling mode unstable, causing the ELM to continue in a peeling mode phase. Understanding the dynamics of ELMs will be a key issue when it comes to controlling and mitigating the ELMs in future large tokamaks. By means of integrated modelling, it is shown that an experimentally observed increase in the ELM frequency and deterioration of plasma confinement triggered by external neutral gas puffing might be due to a transition from the second to

  15. Dependence of recycling and edge profiles on lithium evaporation in high triangularity, high performance NSTX H-mode discharges

    Energy Technology Data Exchange (ETDEWEB)

    Maingi, R., E-mail: rmaingi@pppl.gov [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Osborne, T.H. [General Atomics, 3550 General Atomics Ct., San Diego, CA 92121 (United States); Bell, M.G.; Bell, R.E.; Boyle, D.P. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Canik, J.M. [Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831 (United States); Diallo, A.; Kaita, R.; Kaye, S.M.; Kugel, H.W.; LeBlanc, B.P. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Sabbagh, S.A. [Applied Physics and Applied Math Dept., Columbia University, New York, NY 10027 (United States); Skinner, C.H. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Soukhanovskii, V.A. [Lawrence Livermore National Laboratory, 7000 East Ave, PO Box 808, Livermore, CA 94551 (United States)

    2015-08-15

    In this paper, the effects of a pre-discharge lithium evaporation variation on highly shaped discharges in the National Spherical Torus Experiment (NSTX) are documented. Lithium wall conditioning (‘dose’) was routinely applied onto graphite plasma facing components between discharges in NSTX, partly to reduce recycling. Reduced D{sub α} emission from the lower and upper divertor and center stack was observed, as well as reduced midplane neutral pressure; the magnitude of reduction increased with the pre-discharge lithium dose. Improved energy confinement, both raw τ{sub E} and H-factor normalized to scalings, with increasing lithium dose was also observed. At the highest doses, we also observed elimination of edge-localized modes. The midplane edge plasma profiles were dramatically altered, comparable to lithium dose scans at lower shaping, where the strike point was farther from the lithium deposition centroid. This indicates that the benefits of lithium conditioning should apply to the highly shaped plasmas planned in NSTX-U.

  16. BURNING PLASMA PROJECTIONS USING DRIFT WAVE TRANSPORT MODELS AND SCALINGS FOR THE H-MODE PEDESTAL

    International Nuclear Information System (INIS)

    KINSEY, J.E.; ONJUN, T.; BATEMAN, G.; KRITZ, A.; PANKIN, A.; STAEBLER, G.M.; WALTZ, R.E.

    2002-01-01

    OAK-B135 The GLF23 and Multi-Mode (MM95) transport models are used along with a model for the H-mode pedestal to predict the fusion performance for the ITER, FIRE, and IGNITOR tokamak designs. The drift-wave predictive transport models reproduce the core profiles in a wide variety of tokamak discharges, yet they differ significantly in their response to temperature gradient (stiffness). Recent gyro-kinetic simulations of ITG/TEM and ETG modes motivate the renormalization of the GLF23 model. The normalizing coefficients for the ITG/TEM modes are reduced by a factor of 3.7 while the ETG mode coefficient is increased by a factor of 4.8 in comparison with the original model. A pedestal temperature model is developed for type I ELMy H-mode plasmas based on ballooning mode stability and a theory-motivated scaling for the pedestal width. In this pedestal model, the pedestal density is proportional to the line-averaged density and the pedestal temperature is inversely related to the pedestal density

  17. Fast wave current drive in H mode plasmas on the DIII-D tokamak

    International Nuclear Information System (INIS)

    Petty, C.C.; Grassie, J.S. de; Baity, F.W.

    1999-01-01

    Current driven by fast Alfven waves is measured in H mode and VH mode plasmas on the DIII-D tokamak for the first time. Analysis of the poloidal flux evolution shows that the fast wave current drive profile is centrally peaked but sometimes broader than theoretically expected. Although the measured current drive efficiency is in agreement with theory for plasmas with infrequent ELMs, the current drive efficiency is an order of magnitude too low for plasmas with rapid ELMs. Power modulation experiments show that the reduction in current drive with increasing ELM frequency is due to a reduction in the fraction of centrally absorbed fast wave power. The absorption and current drive are weakest when the electron density outside the plasma separatrix is raised above the fast wave cut-off density by the ELMs, possibly allowing an edge loss mechanism to dissipate the fast wave power since the cut-off density is a barrier for fast waves leaving the plasma. (author)

  18. Operational conditions and characteristics of ELM-events during H-mode plasmas in the stellarator W7-AS

    International Nuclear Information System (INIS)

    Hirsch, M.; Grigull, P.; Wobig, H.; Kisslinger, J.; McCormick, K.; Anton, M.; Baldzuhn, J.; Fiedler, S.; Fuchs, Ch.; Geiger, J.; Giannone, L.; Hartfuss, H.-J.; Holzhauer, E.; Hirsch, M.; Jaenicke, R.; Kick, M.; Maassberg, H.; Wagner, F.; Weller, A.

    2000-01-01

    H-mode operation in the low-shear stellarator W7-AS is achieved for specific plasma edge topologies characterized by three 'operational windows' of the edge rotational transform. An explanation for this strong influence of the magnetic configuration could be the increase of viscous damping if rational surfaces and thus island structures occur within the relevant plasma edge layer, thereby impeding the development of an edge transport barrier. Prior to the final transition to a quiescent state, the plasma edge passes a rich phenomenology of dynamic behaviour such as dithering and ELMs. Plasma edge parameters indicate that a quiescent H-mode occurs if a certain edge pressure is achieved. (author)

  19. H-mode physics

    International Nuclear Information System (INIS)

    Itoh, Sanae.

    1991-06-01

    After the discovery of the H-mode in ASDEX ( a tokamak in Germany ) the transition between the L-mode ( Low confinement mode ) and H-mode ( High confinement mode ) has been observed in many tokamaks in the world. The H-mode has made a breakthrough in improving the plasma parameters and has been recognized to be a universal phenomena. Since its discovery, the extensive studies both in experiments and in theory have been made. The research on H-mode has been casting new problems of an anomalous transport across the magnetic surface. This series of lectures will provide a brief review of experiments for explaining H-mode and a model theory of H-mode transition based on the electric field bifurcation. If the time is available, a new theoretical model of the temporal evolution of the H-mode will be given. (author)

  20. Investigation of EBW Thermal Emission and Mode Conversion Physics in H-Mode Plasmas on NSTX

    International Nuclear Information System (INIS)

    Diem, S.J.; Taylor, G.; Efthimion, P.C.; Kugel, H.W.; LeBlanc, B.P.; Phillips, C.K.; Caughman, J.B.; Wilgen, J.B.; Harvey, R.W.; Preinhaelter, J.; Urban, J.; Sabbagh, S.A.

    2008-01-01

    High β plasmas in the National Spherical Torus Experiment (NSTX) operate in the overdense regime, allowing the electron Bernstein wave (EBW) to propagate and be strongly absorbed/emitted at the electron cyclotron resonances. As such, EBWs may provide local electron heating and current drive. For these applications, efficient coupling between the EBWs and electromagnetic waves outside the plasma is needed. Thermal EBW emission (EBE) measurements, via oblique B-X-O double mode conversion, have been used to determine the EBW transmission efficiency for a wide range of plasma conditions on NSTX. Initial EBE measurements in H-mode plasmas exhibited strong emission before the L-H transition, but the emission rapidly decayed after the transition. EBE simulations show that collisional damping of the EBW prior to the mode conversion (MC) layer can significantly reduce the measured EBE for T e < 20 eV, explaining the observations. Lithium evaporation was used to reduce EBE collisional damping near the MC layer. As a result, the measured B-X-O transmission efficiency increased from < 10% (no Li) to 60% (with Li), consistent with EBE simulations.

  1. Plasma interaction with tungsten samples in the COMPASS tokamak in ohmic ELMy H-modes

    International Nuclear Information System (INIS)

    Dimitrova, M; Weinzettl, V; Matejicek, J; Dejarnac, R; Stöckel, J; Havlicek, J; Panek, R; Popov, Tsv; Marinov, S; Costea, S

    2016-01-01

    This paper reports experimental results on plasma interaction with tungsten samples with or without pre-grown He fuzz. Under the experimental conditions, arcing was observed on the fuzzy tungsten samples, resulting in localized melting of the fuzz structure that did not extend into the bulk. The parallel power flux densities were obtained from the data measured by Langmuir probes embedded in the divertor tiles on the COMPASS tokamak. Measurements of the current-voltage probe characteristics were performed during ohmic ELMy H-modes reached in deuterium plasmas at a toroidal magnetic field B T = 1.15 T, plasma current I p = 300 kA and line-averaged electron density n e = 5×10 19 m -3 . The data obtained between the ELMs were processed by the recently published first-derivative probe technique for precise determination of the plasma potential and the electron energy distribution function (EEDF). The spatial profile of the EEDF shows that at the high-field side it is Maxwellian with a temperature of 5 -- 10 eV. The electron temperatures and the ion-saturation current density obtained were used to evaluate the radial distribution of the parallel power flux density as being in the order of 0.05 -- 7 MW/m 2 . (paper)

  2. Predictive modelling of the impact of argon injection on H-mode plasmas in JET with the RITM code

    International Nuclear Information System (INIS)

    Unterberg, B; Kalupin, D; Tokar', M Z; Corrigan, G; Dumortier, P; Huber, A; Jachmich, S; Kempenaars, M; Kreter, A; Messiaen, A M; Monier-Garbet, P; Ongena, J; Puiatti, M E; Valisa, M; Hellermann, M von

    2004-01-01

    Self-consistent modelling of energy and particle transport of the plasma background and impurities has been performed with the code RITM for argon seeded high density H-mode plasmas in JET. The code can reproduce both the profiles in the plasma core and the structure of the edge pedestal. The impact of argon on core transport is found to be small; in particular, no significant change in confinement is observed in both experimental and modelling results. The same transport model, which has been used to reproduce density peaking in the radiative improved mode in TEXTOR, reveals a flat density profile in Ar seeded JET H-mode plasmas in agreement with the experimental observations. This behaviour is attributed to the rather flat profile of the safety factor in the bulk of H-mode discharges

  3. E-H mode transition in low-pressure inductively coupled nitrogen-argon and oxygen-argon plasmas

    International Nuclear Information System (INIS)

    Lee, Young Wook; Lee, Hye Lan; Chung, T. H.

    2011-01-01

    This work investigates the characteristics of the E-H mode transition in low-pressure inductively coupled N 2 -Ar and O 2 -Ar discharges using rf-compensated Langmuir probe measurements and optical emission spectroscopy (OES). As the ICP power increases, the emission intensities from plasma species, the electron density, the electron temperature, and the plasma potential exhibit sudden changes. The Ar content in the gas mixture and total gas pressure have been varied in an attempt to fully characterize the plasma parameters. With these control parameters varying, the changes of the transition threshold power and the electron energy distribution function (EEDF) are explored. In N 2 -Ar and O 2 -Ar discharges at low-pressures of several millitorr, the transition thresholds are observed to decrease with Ar content and pressure. It is observed that in N 2 -Ar plasmas during the transition, the shape of the EEDF changes from an unusual distribution with a flat hole near the electron energy of 3 eV in the E mode to a Maxwellian distribution in the H mode. However, in O 2 -Ar plasmas, the EEDFs in the E mode at low Ar contents show roughly bi-Maxwellian distributions, while the EEDFs in the H mode are observed to be nearly Maxwellian. In the E and H modes of O 2 -Ar discharges, the dissociation fraction of O 2 molecules is estimated using optical emission actinometry. During the E-H mode transition, the dissociation fraction of molecules is also enhanced.

  4. Pellet injection into H-mode ITER plasma with the presence of internal transport barriers

    Science.gov (United States)

    Leekhaphan, P.; Onjun, T.

    2011-04-01

    The impacts of pellet injection into ITER type-1 ELMy H-mode plasma with the presence of internal transport barriers (ITBs) are investigated using self-consistent core-edge simulations of 1.5D BALDUR integrated predictive modeling code. In these simulations, the plasma core transport is predicted using a combination of a semi-empirical Mixed B/gB anomalous transport model, which can self-consistently predict the formation of ITBs, and the NCLASS neoclassical model. For simplicity, it is assumed that toroidal velocity for ω E× B calculation is proportional to local ion temperature. In addition, the boundary conditions are predicted using the pedestal temperature model based on magnetic and flow shear stabilization width scaling; while the density of each plasma species, including both hydrogenic and impurity species, at the boundary are assumed to be a large fraction of its line averaged density. For the pellet's behaviors in the hot plasma, the Neutral Gas Shielding (NGS) model by Milora-Foster is used. It was found that the injection of pellet could result in further improvement of fusion performance from that of the formation of ITB. However, the impact of pellet injection is quite complicated. It is also found that the pellets cannot penetrate into a deep core of the plasma. The injection of the pellet results in a formation of density peak in the region close to the plasma edge. The injection of pellet can result in an improved nuclear fusion performance depending on the properties of pellet (i.e., increase up to 5% with a speed of 1 km/s and radius of 2 mm). A sensitivity analysis is carried out to determine the impact of pellet parameters, which are: the pellet radius, the pellet velocity, and the frequency of injection. The increase in the pellet radius and frequency were found to greatly improve the performance and effectiveness of fuelling. However, changing the velocity is observed to exert small impact.

  5. Pedestal characteristics and MHD stability of H-mode plasmas in TCV

    International Nuclear Information System (INIS)

    Pitzschke, A.

    2011-01-01

    The tokamak à configuration variable (TCV) is unique in its ability to create a variety of plasma shapes and to heat the electron population in high density regimes using microwave power at the third harmonic of the electron cyclotron frequency. In the frame of this thesis, the impact of plasma shaping and heating on the properties of the edge transport barrier (ETB) in the high confinement mode (H-mode) was studied. This mode of operation is foreseen as one of the reference scenarios for ITER, the International Tokamak Experimental Reactor, which is being built to demonstrate the feasibility of thermonuclear fusion using magnetic confinement. A feature of H-mode regime operation are edge localized modes (ELMs), instabilities driven by the steep pressure gradients that form in the plasma edge region due to a transport barrier. During an ELM event, energy and particles are expelled from the plasma in a short burst. This will cause serious problems with respect to the heat load on plasma facing components in a tokamak of the size of ITER. Understanding of the phenomena associated with ELMs is thus required and dedicated investigations of their theory and experimental observations are carried out in many laboratories worldwide. This thesis presents several experimental and numerical investigations of tokamak behavior for configurations where the plasma edge plays an important role. From the experimental viewpoint, studies of transport barriers are challenging, as plasma parameters change strongly within a narrow spatial region. As part of the work presented here, the TCV Thomson scattering system was upgraded to meet the requirements for diagnosing electron temperature and density with high spatial resolution in the region of internal and external transport barriers. Simultaneously, the data analysis was significantly improved to cope with statistical uncertainties and alleviate possible systematic errors. For measurements of the time evolution of density and

  6. First-wall heat-flux measurements during ELMing H-mode plasma

    International Nuclear Information System (INIS)

    Lasnier, C.J.; Allen, S.L.; Hill, D.N.; Leonard, A.W.; Petrie, T.W.

    1994-01-01

    In this report we present measurements of the diverter heat flux in DIII-D for ELMing H-mode and radiative diverter conditions. In previous work we have examined heat flux profiles in lower single-null diverted plasmas and measured the scaling of the peak heat flux with plasma current and beam power. One problem with those results was our lack of good power accounting. This situation has been improved to better than 80--90% accountability with the installation of new bolometer arrays, and the operation of the entire complement of 5 Infrared (IR) TV cameras using the DAPS (Digitizing Automated Processing System) video processing system for rapid inter-shot data analysis. We also have expanded the scope of our measurements to include a wider variety of plasma shapes (e.g., double-null diverters (DND), long and short single-null diverters (SND), and inside-limited plasmas), as well as more diverse discharge conditions. Double-null discharges are of particular interest because that shape has proven to yield the highest confinement (VH-mode) and beta of all DIII-D plasmas, so any future diverter modifications for DIII-D will have to support DND operation. In addition, the proposed TPX tokamak is being designed for double-null operation, and information on the magnitude and distribution of diverter heat flux is needed to support the engineering effort on that project. So far, we have measured the DND power sharing at the target plates and made preliminary tests of heat flux reduction by gas injection

  7. Tungsten Transport in the Core of JET H-mode Plasmas, Experiments and Modelling

    Science.gov (United States)

    Angioni, Clemente

    2014-10-01

    The physics of heavy impurity transport in tokamak plasmas plays an essential role towards the achievement of practical fusion energy. Reliable predictions of the behavior of these impurities require the development of realistic theoretical models and a complete understanding of present experiments, against which models can be validated. Recent experimental campaigns at JET with the ITER-like wall, with a W divertor, provide an extremely interesting and relevant opportunity to perform this combined experimental and theoretical research. Theoretical models of both neoclassical and turbulent transport must consistently include the impact of any poloidal asymmetry of the W density to enable quantitative predictions of the 2D W density distribution over the poloidal cross section. The agreement between theoretical predictions and experimentally reconstructed 2D W densities allows the identification of the main mechanisms which govern W transport in the core of JET H-mode plasmas. Neoclassical transport is largely enhanced by centrifugal effects and the neoclassical convection dominates, leading to central accumulation in the presence of central peaking of the density profiles and insufficiently peaked ion temperature profiles. The strength of the neoclassical temperature screening is affected by poloidal asymmetries. Only around mid-radius, turbulent diffusion offsets neoclassical transport. Consistently with observations in other devices, ion cyclotron resonance heating in the plasma center can flatten the electron density profile and peak the ion temperature profile and provide a means to reverse the neoclassical convection. MHD activity may hamper or speed up the accumulation process depending on mode number and plasma conditions. Finally, the relationship of JET results to a parallel modelling activity of the W behavior in the core of ASDEX Upgrade plasmas is presented. This project has received funding from the European Union's Horizon 2020 research and innovation

  8. Dependence of helium transport on plasma current and ELM frequency in H-mode discharges in DIII-D

    International Nuclear Information System (INIS)

    Wade, M.R.; Hillis, D.L.; Hogan, J.T.; Finkenthal, D.F.; West, W.P.; Burrell, K.H.; Seraydarian, R.P.

    1993-05-01

    The removal of helium (He) ash from the plasma core with high efficiency to prevent dilution of the D-T fuel mixture is of utmost importance for future fusion devices, such as the International Thermonuclear Experimental Reactor (ITER). A variety of measurements in L-mode conditions have shown that the intrinsic level of helium transport from the core to the edge may be sufficient to prevent sufficient dilution (i.e., τ He /τ E < 5). Preliminary measurements in biased-induced, limited H-mode discharges in TEXTOR suggest that the intrinsic helium transport properties may not be as favorable. If this trend is shown also in diverted H-mode plasmas, then scenarios based on ELMing H-modes would be less desirable. To further establish the database on helium transport in H-mode conditions, recent studies on the DIII-D tokamak have focused on determining helium transport properties in H-mode conditions and the dependence of these properties on plasma current and ELM frequency

  9. Evolution of the radial electric field in a JET H-mode plasma

    International Nuclear Information System (INIS)

    Andrew, Y.; Hawkes, N.C.; Biewer, T.; Crombe, K.; Keeling, D.; De la Luna, E.; Giroud, C.; Korotkov, A.; Meigs, A.; Murari, A.; Nunes, I.; Sartori, R.; Tala, T.; Andrew, Y.; Hawkes, N.C.; Keeling, D.; Giroud, C.; Korotkov, A.; Meigs, A.; Biewer, T.; Crombe, K.; De la Luna, E.; Murari, A.; Nunes, I.; Sartori, R.; Tala, T.

    2008-01-01

    Results from recent measurements of carbon impurity ion toroidal and poloidal rotation velocities, ion temperature, ion density and the resulting radial electric field (E r ) profiles are presented from an evolving Joint European Torus (JET) tokamak plasma over a range of energy and particle confinement regimes. Significant levels of edge plasma poloidal rotation velocity have been measured for the first time on JET, with maximum values of ±9 km/s. Such values of poloidal rotation provide an important contribution to the total edge plasma E r profiles. Large values of shear in the measured E r profiles are observed to arise as a consequence of the presence of the edge transport barrier (ETB) and do not appear to be necessary for their formation or destruction. These results have an important impact on potential mechanisms for transport barrier triggering and sustainment in present-day and future high-performance fusion plasmas. (authors)

  10. Pellet injection into H-mode ITER plasma with the presence of internal transport barriers

    Energy Technology Data Exchange (ETDEWEB)

    Leekhaphan, P. [Thammasat University, School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (Thailand); Onjun, T. [Thammasat University, School of Manufacturing Systems and Mechanical Engineering, Sirindhorn International Institute of Technology (Thailand)

    2011-04-15

    The impacts of pellet injection into ITER type-1 ELMy H-mode plasma with the presence of internal transport barriers (ITBs) are investigated using self-consistent core-edge simulations of 1.5D BALDUR integrated predictive modeling code. In these simulations, the plasma core transport is predicted using a combination of a semi-empirical Mixed B/gB anomalous transport model, which can self-consistently predict the formation of ITBs, and the NCLASS neoclassical model. For simplicity, it is assumed that toroidal velocity for {omega}{sub E Multiplication-Sign B} calculation is proportional to local ion temperature. In addition, the boundary conditions are predicted using the pedestal temperature model based on magnetic and flow shear stabilization width scaling; while the density of each plasma species, including both hydrogenic and impurity species, at the boundary are assumed to be a large fraction of its line averaged density. For the pellet's behaviors in the hot plasma, the Neutral Gas Shielding (NGS) model by Milora-Foster is used. It was found that the injection of pellet could result in further improvement of fusion performance from that of the formation of ITB. However, the impact of pellet injection is quite complicated. It is also found that the pellets cannot penetrate into a deep core of the plasma. The injection of the pellet results in a formation of density peak in the region close to the plasma edge. The injection of pellet can result in an improved nuclear fusion performance depending on the properties of pellet (i.e., increase up to 5% with a speed of 1 km/s and radius of 2 mm). A sensitivity analysis is carried out to determine the impact of pellet parameters, which are: the pellet radius, the pellet velocity, and the frequency of injection. The increase in the pellet radius and frequency were found to greatly improve the performance and effectiveness of fuelling. However, changing the velocity is observed to exert small impact.

  11. H-mode edge stability of Alcator C-mod plasmas

    International Nuclear Information System (INIS)

    Mossessian, D.A.; Hubbard, A.; Hughes, J.W.; Greenwald, M.; LaBombard, B.; Snipes, J.A.; Wolfe, S.; Snyder, P.; Wilson, H.; Xu, X.; Nevins, W.

    2003-01-01

    For steady state H-mode operation, a relaxation mechanism is required to limit build-up of the edge gradient and impurity content. C-Mod sees two such mechanisms - EDA and grassy ELMs, but not large type I ELMs. In EDA the edge relaxation is provided by an edge localized quasi coherent electromagnetic mode that exists at moderate pedestal temperature T 3.5 and does not limit the build up of the edge pressure gradient. The mode is not observed in the ideal MHD stability analysis, but is recorded in the nonlinear real geometry fluctuations modeling based on fluid equations and is thus tentatively identified as a resistive ballooning mode. At high edge pressure gradients and temperatures the mode is replaced by broadband fluctuations (f< 50 kHz) and small irregular ELMs are observed. Based on ideal MHD calculations that include the effects of edge bootstrap current, these ELMs are identified as medium n (10 < n < 50) coupled peeling/ballooning modes. The stability thresholds, its dependence on the plasma shape and the modes structure are studied experimentally and with the linear MHD stability code ELITE. (author)

  12. On impurity handling in high performance stellarator/heliotron plasmas

    International Nuclear Information System (INIS)

    Burhenn, R.; Feng, Y.; Ida, K.

    2008-10-01

    The Large Helical Device (LHD) and Wendelstein 7-X (W7-X, under construction) are experiments specially designed to demonstrate long pulse (quasi steady-state) operation, which is an intrinsic property of Stellarators and Heliotrons. Significant progress was made in establishment of high performance plasmas. A crucial point is the increasing impurity confinement towards high density as observed at several machines (TJ-II, W7-AS, LHD) which can lead to impurity accumulation and early pulse termination by radiation collapse at high density. In addition, theoretical predictions for non-axisymmetric configurations prognosticate the absence of impurity screening by ion temperature gradients in standard ion root plasmas. Nevertheless, scenarios were found where impurity accumulation was successfully avoided in LHD and/or W7-AS by the onset of drag forces in the high density and low temperature scrape-off-layer, the generation of magnetic islands at the plasma boundary and to a certain degree also by ELMs, flushing out impurities and reducing the net-impurity influx into the core. Additionally, a reduction of impurity core confinement was observed in the W7-AS High Density H-mode (HDH) regime and by application of sufficient ECRH heating power. The exploration of such purification mechanisms is a demanding task for successful steady-state operation. The impurity transport at the plasma edge/SOL was identified to play a major role for the global impurity behaviour in addition to the core confinement. (author)

  13. Ion orbit loss and pedestal width of H-mode tokamak plasmas in limiter geometry

    International Nuclear Information System (INIS)

    Xiao Xiaotao; Liu Lei; Zhang Xiaodong; Wang Shaojie

    2011-01-01

    A simple analytical model is proposed to analyze the effects of ion orbit loss on the edge radial electric field in a tokamak with limiter configuration. The analytically predicted edge radial electric field is consistent with the H-mode experiments, including the width, the magnitude, and the well-like shape. This model provides an explanation to the H-mode pedestal structure. Scaling of the pedestal width based on this model is proposed.

  14. The Effect of Plasma Shape on H-Mode Pedestal Characteristics on DIII-D

    International Nuclear Information System (INIS)

    T.H. Osborne; J.R. Ferron; R.J. Groebner; L.L. Lao; A.W. Leonard; R. Maingi; R.L. Miller; A.D. Turnbull; M.R. Wade; J.G. Watkins

    1999-01-01

    The characteristics of the H-mode are studied in discharges with varying triangularity and squareness. The pressure at the top of the H-mode pedestal increases strongly with triangularity primarily due to an increase in the margin by which the edge pressure gradient exceeds the ideal ballooning mode first stability limit. Two models are considered for how the edge may exceed the ballooning mode limit. In one model [1], access to the ballooning mode second stable regime allows the edge pressure gradient and associated bootstrap current to continue to increase until an edge localized, low toroidal mode number, ideal kink mode is destabilized. In the second model [2], the finite width of the H-mode transport barrier, and diamagnetic effects raise the pressure gradient limit above the ballooning mode limit. We observe a weak inverse dependence of the width of the H-mode transport barrier, Δ, on triangularity relative to the previously obtained [3] scaling Δ ∞ (β P PED ) 1/2 . The energy loss for Type I ELMs increases with triangularity in proportion to the pedestal energy increase. The temperature profile is found to respond stiffly to changes in T PED at low temperature, while at high temperature the response is additive. The response of the density profile is also found to play a role in the response of the total stored energy to changes in the W PED

  15. Integrated plasma control for high performance tokamaks

    International Nuclear Information System (INIS)

    Humphreys, D.A.; Deranian, R.D.; Ferron, J.R.; Johnson, R.D.; LaHaye, R.J.; Leuer, J.A.; Penaflor, B.G.; Walker, M.L.; Welander, A.S.; Jayakumar, R.J.; Makowski, M.A.; Khayrutdinov, R.R.

    2005-01-01

    Sustaining high performance in a tokamak requires controlling many equilibrium shape and profile characteristics simultaneously with high accuracy and reliability, while suppressing a variety of MHD instabilities. Integrated plasma control, the process of designing high-performance tokamak controllers based on validated system response models and confirming their performance in detailed simulations, provides a systematic method for achieving and ensuring good control performance. For present-day devices, this approach can greatly reduce the need for machine time traditionally dedicated to control optimization, and can allow determination of high-reliability controllers prior to ever producing the target equilibrium experimentally. A full set of tools needed for this approach has recently been completed and applied to present-day devices including DIII-D, NSTX and MAST. This approach has proven essential in the design of several next-generation devices including KSTAR, EAST, JT-60SC, and ITER. We describe the method, results of design and simulation tool development, and recent research producing novel approaches to equilibrium and MHD control in DIII-D. (author)

  16. Physics of integrated high-performance NSTX plasmas

    International Nuclear Information System (INIS)

    Menard, J. E.; Bell, M. G.; Bell, R. E.; Fredrickson, E. D.; Gates, D. A.; Heidbrink, W.; Kaita, R.; Kaye, S. M.; Kessel, C. E.; Kugel, H.; LeBlanc, B. P.; Lee, K. C.; Levinton, F. M.; Maingi, R.; Medley, S. S.; Mikkelsen, D. R.; Mueller, D.; Nishino, N.; Ono, M.; Park, H.; Park, W.; Paul, S. F.; Peebles, T.; Peng, M.; Raman, R.; Redi, M.; Roquemore, L.; Sabbagh, S. A.; Skiner, C. H.; Sontag, A.; Soukhanovskii, V.; Stratton, B.; Stutman, D.; Synakowski, E.; Takase, Y.; Taylor, G.; Tritz, K.; Wade, M.; Wilson, J. R.; Zhu, W.

    2005-01-01

    An overarching goal of magnetic fusion research is the integration of steady state operation with high fusion power density, high plasma β, good thermal and fast particle confinement, and manageable heat and particle fluxes to reactor internal components. NSTX has made significant progress in integrating and understanding the interplay between these competing elements. Sustained high elongation up to 2.5 and H-mode transitions during the I p ramp-up have increased β p and reduced l i at high current resulting in I p flat-top durations exceeding 0.8s for I p >0.8MA. These shape and profile changes delay the onset of deleterious global MHD activity yielding β N values >4.5 and β T ∼20% maintained for several current diffusion times. Higher ∫ N discharges operating above the non-wall limit are sustained via rotational stabilization of the RWM. H-mode confinement scaling factors relative to H98(y,2) span the range 1±0.4 for B T >4kG and show a stron (Nearly linear) residual scaling with B T . Power balance analysis indicates the electron thermal transport dominates the loss power in beam-heated H m ode discharges, but the core χ e can be significantly reduced through current profile modification consistent with reversed magnetic shear. Small ELM regimes have been obtained in high performance plasmas on NSTX, but the ELM type and associated pedestal energy loss are found to depend sensitively on the boundary elongation, magnetic balance, and edge collisionality. NPA data and TRANSP analysis suggest resonant interactions with mid-radius tearing modes may lead to large fast-ion transport. The associated fast-ion diffusion and/or loss likely impact(s) both the driven current and power deposition profiles from NBI heating. Results from experiments to initiate the plasma without the ohmic solenoid and integrated scenario with the TSC code will also be described. (Author)

  17. First HIBP Measurement of Plasma Potential During the H-Mode Transition on the TUMAN-3M Tokamak

    International Nuclear Information System (INIS)

    Askinazi, L.G.; Golant, V.E.; Kornev, V.A.; Lebedev, S.V.; Shevkin, E.A.; Tukachinsky, A.S.; Zhubr, N.A.; Chmyga, A.A.; Dreval, N.B.; Khrebtov, S.M.; Komarov, A.S.; Krupnik, L.I.; Oost, G. van; Tendler, M.

    2003-01-01

    The difficulty of Heavy Ion Beam Probe (HIBP) application on the TUMAN-3M (R=0.53m, a=0.22m, BT=0.8T, Ip=140kA, Te=0.5keV, n<4 1019m-3) -- significant toroidal shift of beam trajectory -- is caused by high ratio of poloidal field to toroidal one. Strong UV radiation from the plasma loads the energy analyzer's detector and complicates the problem even more. This paper presents the results of first measurement of plasma potential evolution in the discharges performed in ohmic H-mode using 80 keV K+ beam and a Proca-Green secondary ion energy analyzer. Spatial region covered by the diagnostic in the experiments discussed was 0< r<0.6a. Spatial scan was performed utilizing the toroidal field decrease due to capacity power supply battery discharge. The change in plasma potential of the order of 100V has been measured during the H-mode formation. The potential in core plasma (r<0.6a) starts to change simultaneously with L-H transition, and than changes during ∼6-8ms after the transition. Thus, the potential changes rather slowly in a comparison with L-H transition timescale (∼2ms for TUMAN-3M ohmic H-mode). Possible explanation to the slow change in central plasma potential may be a formation of potential well structure at the plasma edge, in which radial electric field changes direction. This kind of structure is beneficial for the edge turbulent transport suppression because of high |∂Er/∂r|, but not necessary requires a strong change in central plasma potential to occur immediately. The results from microwave reflectometry support this hypothesis

  18. Effect of variation in equilibrium shape on ELMing H-mode performance in DIII-D diverted plasmas

    International Nuclear Information System (INIS)

    Fenstermacher, M.E.; Osborne, T.H.; Petrie, T.W.

    2001-01-01

    The changes in the performance of the core, pedestal, scrape-off-layer (SOL), and divertor plasmas as a result of changes in triangularity, δ, up/down magnetic balance, and secondary divertor volume were examined in shape variation experiments using ELMing H mode plasmas on DIII-D. In moderate density, unpumped plasmas, high δ∼0.7 increased the energy in the H mode pedestal and the global energy confinement of the core, primarily due to an increase in the margin by which the edge pressure gradient exceeded the value which would have been expected had it been limited by infinite-n ideal ballooning modes. In addition, a nearly balanced double-null (DN) shape was effective for sharing the peak heat flux in the divertor in these attached plasmas. For detached plasmas good heat flux sharing was obtained for a substantial range of unbalanced DN shapes. Finally, the presence of a second X-point in unbalanced DN shapes did not degrade the plasma performance if it was sufficiently far inside the vacuum vessel. These results indicate that a high δ unbalanced DN shape has some advantages over a single null shape for future high power tokamak operation. (author)

  19. Plasma-edge gradients in L-mode and ELM-free H-mode JET plasmas

    International Nuclear Information System (INIS)

    Breger, P.; Zastrow, K.-D.; Davies, S.J.; K ig, R.W.T.; Summers, D.D.R.; Hellermann, M.G. von; Flewin, C.; Hawkes, N.C.; Pietrzyk, Z.A.; Porte, L.

    1998-01-01

    Experimental plasma-edge gradients in JET during the edge-localized-mode (ELM) free H-mode are examined for evidence of the presence and location of the transport barrier region inside the magnetic separatrix. High spatial resolution data in electron density is available in- and outside the separatrix from an Li-beam diagnostic, and in electron temperature inside the separatrix from an ECE diagnostic, while outside the separatrix, a reciprocating probe provides electron density and temperature data in the scrape-off layer. Ion temperatures and densities are measured using an edge charge-exchange diagnostic. A comparison of observed widths and gradients of this edge region with each other and with theoretical expectations is made. Measurements show that ions and electrons form different barrier regions. Furthermore, the electron temperature barrier width (3-4 cm) is about twice that of electron density, in conflict with existing scaling laws. Suitable parametrization of the edge data enables an electron pressure gradient to be deduced for the first time at JET. It rises during the ELM-free phase to reach only about half the marginal pressure gradient expected from ballooning stability before the first ELM. Subsequent type I ELMs occur on a pressure gradient contour roughly consistent with both a constant barrier width model and a ballooning mode envelope model. (author)

  20. Study of density fluctuation in L-mode and H-mode plasmas on JFT-2M by microwave reflectometer

    International Nuclear Information System (INIS)

    Shinohara, Kouji

    1997-08-01

    We propose the model which can explain the runaway phase. The model takes account of the scattered wave which is caused by the density fluctuation near the cut-off layer. We should take a new approach instead of the conventional phase measurement in order to derive the information of the density fluctuation from the data with the runaway phase. The complex spectrum and the rotary spectrum analyses are useful tools to analyze such data. The density fluctuation in L-mode and H-mode plasmas is discussed by using this new approach. We have observed that the reduction of the density fluctuation is localized in the edge region where the sheared electric field is produced. The fluctuations in the range of frequency lower than 100 kHz are mainly reduced. Two interesting features have been observed. One is the detection of the coherent mode around 100 kHz in H-mode. This mode appears about 10 ms after L to H transition. The timing corresponds to the formation of a steep density and temperature gradient in the edge region. The other is the enhancement of the fluctuations with the frequency higher than 300 kHz in H-mode in contrast to the reduction of the fluctuations with the frequency lower than 100 kHz. The Doppler shift is observed in the complex auto-power spectrum of the reflected wave when the plasma is actively moved. We have confirmed that the movement of the plasma is appropriately measured by using the low pass filter. The reflectometer can be used to measure the density profile by using a low pass filter even when the runaway phase phenomenon occurs. (author). 150 refs

  1. Characteristics of edge pedestals in LHW and NBI heated H-mode plasmas on EAST

    Science.gov (United States)

    Zang, Q.; Wang, T.; Liang, Y.; Sun, Y.; Chen, H.; Xiao, S.; Han, X.; Hu, A.; Hsieh, C.; Zhou, H.; Zhao, J.; Zhang, T.; Gong, X.; Hu, L.; Liu, F.; Hu, C.; Gao, X.; Wan, B.; the EAST Team

    2016-10-01

    By using the recently developed Thomson scattering diagnostic, the pedestal structure of the H-mode with neutral beam injection (NBI) or/and lower hybrid wave (LHW) heating on EAST (Experimental Advanced Superconducting Tokamak) is analyzed in detail. We find that a higher ratio of the power of the NBI to the total power of the NBI and the lower hybrid wave (LHW) will produce a large and regular different edge-localized mode (ELM), and a lower ratio will produce a small and irregular ELM. The experiments show that the mean pedestal width has good correlation with β \\text{p,\\text{ped}}0.5 , The pedestal width appears to be wider than that on other similar machines, which could be due to lithium coating. However, it is difficult to draw any conclusion of correlation between ρ * and the pedestal width for limited ρ * variation and scattered distribution. It is also found that T e/\

  2. Nonlinear theory of trapped electron temperature gradient driven turbulence in flat density H-mode plasmas

    International Nuclear Information System (INIS)

    Hahm, T.S.

    1990-12-01

    Ion temperature gradient turbulence based transport models have difficulties reconciling the recent DIII-D H-mode results where the density profile is flat, but χ e > χ i in the core region. In this work, a nonlinear theory is developed for recently discovered ion temperature gradient trapped electron modes propagating in the electron diamagnetic direction. This instability is predicted to be linearly unstable for L Ti /R approx-lt κ θ ρ s approx-lt (L Ti /R) 1/4 . They are also found to be strongly dispersive even at these long wavelengths, thereby suggesting the importance of the wave-particle-wave interactions in the nonlinear saturation phase. The fluctuation spectrum and anomalous fluxes are calculated. In accordance with the trends observed in DIII-D, the predicted electron thermal diffusivity can be larger than the ion thermal diffusivity. 17 refs., 3 figs

  3. Enhancement of mode-converted electron Bernstein wave emission during National Spherical Torus Experiment H-mode plasmas

    International Nuclear Information System (INIS)

    Taylor, G.; Efthimion, P.C.; Jones, B.; Le Blanc, B.P.; Maingi, R.

    2002-01-01

    A sudden, threefold increase in emission from fundamental electrostatic electron Bernstein waves (EBW) which mode convert and tunnel to the electromagnetic X-mode has been observed during high energy and particle confinement (H-mode) transitions in the National Spherical Torus Experiment (NSTX) plasma [M. Ono, S. Kaye, M. Peng et al., in Proceedings of the 17th IAEA Fusion Energy Conference (IAEA, Vienna, Austria, 1999), Vol. 3, p. 1135]. The mode-converted EBW emission viewed normal to the magnetic field on the plasma midplane increases when the density profile steepens in the vicinity of the mode conversion layer, which is located in the plasma scrape off. The measured conversion efficiency during the H-mode is consistent with the calculated EBW to X-mode conversion efficiency derived using edge density data. Calculations indicate that there may also be a small residual contribution to the measured X-mode electromagnetic radiation from polarization-scrambled, O-mode emission, converted from EBWs

  4. Investigation of the hydrogen fluxes in the plasma edge of W7-AS during H-mode discharges

    International Nuclear Information System (INIS)

    Langer, U.; Taglauer, E.; Fischer, R.

    2001-01-01

    In the stellarator W7-AS the H-mode is characterized by an edge transport barrier which is localized within a few centimeters inside the separatrix. The corresponding L-H transition shows well-known features such as the steepening of the temperature and density profiles in the region of the separatrix. With a so-called sniffer probe the temporal development of the hydrogen and deuterium fluxes has been studied in the plasma edge during different H-mode discharges with deuterium gas puffing. Prior to the transition a significant reduction of the deuterium and also the hydrogen fluxes can be observed. This fact confirms the assumption that the steepening of the density profiles starts at the outermost edge of the plasma. Moreover, sniffer probe measurements in the plasma edge could therefore identify a precursor for the L-H transition. The analysis of the hydrogen neutral gases shows a distinct change of the hydrogen isotope ratio during the transition. This observation is in agreement with the change in the particle fluxes onto the targets and can also be seen in the reduced H α signals from the limiters. It is further demonstrated that significant improvement in the time resolution of the measured data can be obtained by deconvolution of the data with the apparatus function using Bayesian probability theory and the Maximum Entropy method with adaptive kernels

  5. Kinetic equilibrium reconstruction for the NBI- and ICRH-heated H-mode plasma on EAST tokamak

    Science.gov (United States)

    Zhen, ZHENG; Nong, XIANG; Jiale, CHEN; Siye, DING; Hongfei, DU; Guoqiang, LI; Yifeng, WANG; Haiqing, LIU; Yingying, LI; Bo, LYU; Qing, ZANG

    2018-04-01

    The equilibrium reconstruction is important to study the tokamak plasma physical processes. To analyze the contribution of fast ions to the equilibrium, the kinetic equilibria at two time-slices in a typical H-mode discharge with different auxiliary heatings are reconstructed by using magnetic diagnostics, kinetic diagnostics and TRANSP code. It is found that the fast-ion pressure might be up to one-third of the plasma pressure and the contribution is mainly in the core plasma due to the neutral beam injection power is primarily deposited in the core region. The fast-ion current contributes mainly in the core region while contributes little to the pedestal current. A steep pressure gradient in the pedestal is observed which gives rise to a strong edge current. It is proved that the fast ion effects cannot be ignored and should be considered in the future study of EAST.

  6. Edge radial electric field structure in quiescent H-mode plasmas in the DIII-D tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Burrell, K H [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); West, W P [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Doyle, E J [University of California, Los Angeles, CA 90095-1597 (United States); Austin, M E [University of Texas at Austin, Austin, TX 78712 (United States); DeGrassie, J S [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Gohil, P [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Greenfield, C M [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Groebner, R J [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Jayakumar, R [Lawrence Livermore National Laboratory, Livermore, CA 94551-9900 (United States); Kaplan, D H [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Lao, L L [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Leonard, A W [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Makowski, M A [Lawrence Livermore National Laboratory, Livermore, CA 94551-9900 (United States); McKee, G R [University of Wisconsin, Madison, WI 53706-1687 (United States); Solomon, W M [Princeton Plasma Physics Laboratory, Princeton, NJ 08543-0451 (United States); Thomas, D M [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States); Rhodes, T L [University of California, Los Angeles, CA 90095-1597 (United States); Wade, M R [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Wang, G [University of California, Los Angeles, CA 90095-1597 (United States); Watkins, J G [Sandia National Laboratories, Albuquerque, NM 87185 (United States); Zeng, L [University of California, Los Angeles, CA 90095-1597 (United States)

    2004-05-01

    H-mode operation is the choice for next step tokamak devices based on either conventional or advanced tokamak physics. This choice, however, comes at a significant cost for both the conventional and advanced tokamaks because of the effects of edge localized modes (ELMs). ELMs can produce significant erosion in the divertor and can affect the {beta} limit and reduced core transport regions needed for advanced tokamak operation. Experimental results from DIII-D over the past four years have demonstrated a new operating regime, the quiescent H-mode (QH-mode) regime, that solves these problems. QH-mode plasmas have now been run for over 4 s (>30 energy confinement times). Utilizing the steady-state nature of the QH-mode edge allows us to obtain unprecedented spatial resolution of the edge ion profiles and the edge radial electric field, E{sub r}, by sweeping the edge plasma slowly past the view points of the charge exchange spectroscopy system. We have investigated the effects of direct edge ion orbit loss on the creation and sustainment of the QH-mode. Direct loss of ions injected into the velocity-space loss cone at the plasma edge is not necessary for creation or sustainment of the QH-mode. The direct ion orbit loss has little effect on the edge E{sub r} well. The E{sub r} at the bottom of the well in these cases is about -100 kV m{sup -1} compared with -20 to -30 kV m{sup -1} in the standard H-mode. The well is about 1 cm wide, which is close to the diameter of the deuteron gyro-orbit. We also have investigated the effect of changing edge triangularity by changing the plasma shape from upwardly biased single null to magnetically balanced double null. We have now achieved the QH-mode in these double-null plasmas. The increased triangularity allows us to increase pedestal density in QH-mode plasmas by a factor of about 2.5 and overall pedestal pressure by a factor of 2. Pedestal {beta} and {nu}{sup *} values matching the values desired for ITER have been achieved. In

  7. Miniaturized high performance sensors for space plasmas

    International Nuclear Information System (INIS)

    Young, D.T.

    1996-01-01

    Operating under ever more constrained budgets, NASA has turned to a new paradigm for instrumentation and mission development in which smaller, faster, better, cheaper is of primary consideration for future space plasma investigations. The author presents several examples showing the influence of this new paradigm on sensor development and discuss certain implications for the scientific return from resource constrained sensors. The author also discusses one way to improve space plasma sensor performance which is to search out new technologies, measurement techniques and instrument analogs from related fields including among others, laboratory plasma physics

  8. Tungsten transport and sources control in JET ITER-like wall H-mode plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Fedorczak, N., E-mail: nicolas.fedorczak@cea.fr [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Monier-Garbet, P. [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Pütterich, T. [MPI für Plasmaphysik, EURATOM Association, Boltzmannstrasse 2, 85748 Garching (Germany); Brezinsek, S. [Institute of Energy and Climate Research, Forschungszentrum Jlich, Assoc EURATOM-FZJ, Jlich (Germany); Devynck, P.; Dumont, R.; Goniche, M.; Joffrin, E. [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Lerche, E. [Association EURATOM-Belgian State, LPP-ERM-KMS, TEC partner, Brussels (Belgium); Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Lipschultz, B. [York Plasma Institute, University of York, Heslington, York YO10 5DD (United Kingdom); Luna, E. de la [Laboratorio Nacional de Fusin, Asociacin EURATOM/CIEMAT, 28040 Madrid (Spain); Maddison, G. [Culham Centre for Fusion Energy, EURATOM-CCFE Association, Abingdon (United Kingdom); Maggi, C. [MPI für Plasmaphysik, EURATOM Association, Boltzmannstrasse 2, 85748 Garching (Germany); Matthews, G. [Culham Centre for Fusion Energy, EURATOM-CCFE Association, Abingdon (United Kingdom); Nunes, I. [Istituto de plasmas e fusao nuclear, Lisboa (Portugal); Rimini, F. [Culham Centre for Fusion Energy, EURATOM-CCFE Association, Abingdon (United Kingdom); Solano, E.R. [Laboratorio Nacional de Fusin, Asociacin EURATOM/CIEMAT, 28040 Madrid (Spain); Tamain, P. [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Tsalas, M. [Association EURATOM-Hellenic Republic, NCSR Demokritos 153 10, Attica (Greece); Vries, P. de [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France)

    2015-08-15

    A set of discharges performed with the JET ITER-like wall is investigated with respect to control capabilities on tungsten sources and transport. In attached divertor regimes, increasing fueling by gas puff results in higher divertor recycling ion flux, lower divertor tungsten source, higher ELM frequency and lower core plasma radiation, dominated by tungsten ions. Both pedestal flushing by ELMs and divertor screening (including redeposition) are possibly responsible. For specific scenarios, kicks in plasma vertical position can be employed to increase the ELM frequency, which results in slightly lower core radiation. The application of ion cyclotron radio frequency heating at the very center of the plasma is efficient to increase the core electron temperature gradient and flatten electron density profile, resulting in a significantly lower central tungsten peaking. Beryllium evaporation in the main chamber did not reduce the local divertor tungsten source whereas core radiation was reduced by approximately 50%.

  9. Characterization of fueling NSTX H-mode plasmas diverted to a liquid lithium divertor

    Energy Technology Data Exchange (ETDEWEB)

    Kaita, R., E-mail: kaita@pppl.gov [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Kugel, H.W.; Abrams, T. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Allain, J.P. [Purdue University, West Lafayette, IN 47907 (United States); Bell, M.G.; Bell, R.E.; Diallo, A.; Gerhardt, S.P. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Heim, B. [Purdue University, West Lafayette, IN 47907 (United States); Jaworski, M.A., E-mail: mjaworsk@pppl.gov [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Kallman, J. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Kaye, S.; LeBlanc, B.P. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Maingi, R. [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Mansfield, D. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); McLean, A. [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Menard, J.; Mueller, D. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); Nygren, R. [Sandia National Laboratories, Albuquerque, NM 87185 (United States); Ono, M. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ 08543 (United States); and others

    2013-07-15

    Deuterium fueling experiments were conducted with the NSTX Liquid Lithium Divertor (LLD). Lithium evaporation recoated the LLD surface to approximate flowing liquid Li to sustain D retention. In the first experiment with the diverted outer strike point on the LLD, the difference between the applied D gas input and the plasma D content reached very high values without disrupting the plasma, as would normally occur in the absence of Li pumping, and there was also little change in plasma D content. In the second experiment, constant fueling was applied, as the LLD temperature was varied to change the surface from solid to liquid. The D retention was relatively constant, and about the same as that for solid Li coatings on graphite, or twice that achieved without Li PFC coatings. Contamination of the LLD surface was also possible due to compound formation and erosion and redeposition from carbon PFCs.

  10. Direct measurements of the plasma potential in ELMy H-mode plasma with ball-pen probes on ASDEX Upgrade tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Adamek, J., E-mail: adamek@ipp.cas.c [Institute of Plasma Physics, Association EURATOM/IPP.CR, Prague, Za Slovankou 3, 182 00, Prague 8 (Czech Republic); Rohde, V.; Mueller, H.W.; Herrmann, A. [Institute of Plasma Physics, Association EURATOM/IPP, Garching (Germany); Ionita, C.; Schrittwieser, R.; Mehlmann, F. [Institute for Ion Physics and Applied Physics, University of Innsbruck, Association EURATOM/OAW (Austria); Stoeckel, J.; Horacek, J.; Brotankova, J. [Institute of Plasma Physics, Association EURATOM/IPP.CR, Prague, Za Slovankou 3, 182 00, Prague 8 (Czech Republic)

    2009-06-15

    Experimental investigations of the plasma potential and electric field were performed for ELMy H-mode plasmas in the vicinity of the limiter shadow of ASDEX Upgrade. A fast reciprocating probe with a probe head containing four ball-pen probes (BPPs) [J. Adamek et al., Czech. J. Phys. 54 (2004) C95 - C99.] was used on the midplane manipulator. Different gradients of the plasma potential were observed during ELMs and in between them. The temporal resolution of the direct plasma potential measurements with BPP was determined by using power-spectra analysis.

  11. Turbulence at the transition to the high density H-mode in Wendelstein 7-AS plasmas

    DEFF Research Database (Denmark)

    Basse, N.P.; Zoletnik, S.; Baumel, S.

    2003-01-01

    Recently a new improved confinement regime was found in the Wendelstein 7-AS (W7-AS) stellarator (Renner H. et al 1989 Plasma Phys. Control. Fusion 31 1579). The discovery of this high density high confinement mode (HDH-mode) was facilitated by the installation of divertor modules. In this paper,...

  12. ELMy-H mode as limit cycle and chaotic oscillations in tokamak plasmas

    International Nuclear Information System (INIS)

    Itoh, Sanae; Itoh, Kimitaka; Fukuyama, Atsushi.

    1991-06-01

    A model of Edge Localized Modes (ELMs) in tokamaks is presented. A limit cycle solution is found in time-dependent Ginzburg Landau type model equation of L/H transition, which has a hysteresis curve between the plasma gradient and flux. The oscillation of edge density appears near the L/H transition boundary. Spatial structure of the intermediate state (mesophase) is obtained in the edge region. Chaotic oscillation is predicted due to random neutrals and external oscillations. (author)

  13. Magnetic perturbation experiments on MAST L- and H-mode plasmas using internal coils

    Czech Academy of Sciences Publication Activity Database

    Kirk, A.; Liu, Y.Q.; Nardon, E.; Tamain, P.; Cahyna, Pavel; Chapman, I.; Denner, P.; Meyer, H.; Mordijck, S.; Temple, D.

    2011-01-01

    Roč. 53, č. 6 (2011), 065011-065011 ISSN 0741-3335 R&D Projects: GA ČR GAP205/11/2341 Institutional research plan: CEZ:AV0Z20430508 Keywords : Resonant magnetic perturbations * L-H transition * spherical tokamaks * edge localized modes Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.425, year: 2011 http://dx.doi.org/10.1088/0741-3335/53/6/065011

  14. ELMy-H mode as limit cycle and chaotic oscillations in tokamak plasmas

    International Nuclear Information System (INIS)

    Itoh Sanae, I.; Itoh, Kimitaka; Fukuyama, Atsushi; Miura, Yukitoshi.

    1991-05-01

    A model of Edge Localized Modes (ELMs) in tokamak plasmas is presented. A limit cycle solution is found in the transport equation (time-dependent Ginzburg-Landau type), which a has hysteresis curve between the gradient and flux. Periodic oscillation of the particle outflux and L/H intermediate state are predicted near the L/H transition boundary. A mesophase in spatial structure appears near edge. Chaotic oscillation is also predicted. (author)

  15. H-mode access during plasma current ramp-up in TCV

    International Nuclear Information System (INIS)

    Martin, Y.; Behn, R.; Furno, I.; Labit, B.; Reimerdes, H.

    2014-01-01

    A recent TCV experiment has investigated the dependence of the L–H transition threshold power on the plasma current ramp-rate and the X-point height above the divertor target, which both have previously been seen to affect the transition behaviour. Systematic scans in ohmically heated plasmas do not show any dependence on the plasma current ramp-up rate. In contrast, the threshold power is found to increase by a factor of two while the X-point is moved from about 10 cm up to 35 cm above the vessel floor. However, further increase, up to 60 cm, does not lead to any further increase of the required power. The Fundamenski et al model is tested against the measurements. Estimates of the Wagner number (Wa) at L–H transitions are generally close to unity, in accordance with the model. In contrast, estimates of Wa before the L–H transition, i.e. in L-mode, do not show the expected evolution towards unity. (paper)

  16. High-frequency coherent edge fluctuations in a high-pedestal-pressure quiescent H-mode plasma.

    Science.gov (United States)

    Yan, Z; McKee, G R; Groebner, R J; Snyder, P B; Osborne, T H; Burrell, K H

    2011-07-29

    A set of high frequency coherent (HFC) modes (f=80-250 kHz) is observed with beam emission spectroscopy measurements of density fluctuations in the pedestal of a strongly shaped quiescent H-mode plasma on DIII-D, with characteristics predicted for kinetic ballooning modes (KBM): propagation in the ion-diamagnetic drift direction; a frequency near 0.2-0.3 times the ion-diamagnetic frequency; inferred toroidal mode numbers of n∼10-25; poloidal wave numbers of k(θ)∼0.17-0.4 cm(-1); and high measured decorrelation rates (τ(c)(-1)∼ω(s)∼0.5×10(6) s(-1)). Their appearance correlates with saturation of the pedestal pressure. © 2011 American Physical Society

  17. A Comparison of Plasma Performance Between Single-Null and Double-Null Configurations During Elming H-Mode

    International Nuclear Information System (INIS)

    Petrie, T.W.; Fenstermacher, M.E.; Allen, S.L.; Carlstrom, T.N.; Gohil, P.; Groebner, R.J.; Greenfield, C.M.; Hyatt, A.W.; Lasnier, C.J.; La Haye, R.J.; Leonard, A.W.; Mahdavi, M.A.; Osborne, T.H.; Porter, G.D.; Rhodes, T.L.; Thomas, D.M.; Watkins, J.G.; West, W.P.; Wolf, N.S.

    1999-01-01

    Tokamak plasma performance generally improves with increased shaping of the plasma cross section, such as higher elongation and higher triangularity. The stronger shaping, especially higher triangularity, leads to changes in the magnetic topology of the divertor. Because there are engineering and divertor physics issues associated with changes in the details of the divertor flux geometry, especially as the configuration transitions from a single-null (SN) divertor to a marginally balanced double-null (DN) divertor, we have undertaken a systematic evaluation of the plasma characteristics as the magnetic geometry is varied, particularly with respect to (1) energy confinement, (2) the response of the plasma to deuterium gas fueling, (3) the operational density range for the ELMing H-mode, and (4) heat flux sharing by the diverters. To quantify the degree of divertor imbalance (or equivalently, to what degree the shape is double-null or single-null), we define a parameter DRSEP. DRSEP is taken as the radial distance between the upper divertor separatrix and the lower divertor separatrix, as determined at the outboard midplane. For example, if DRSEP=O, the configuration is a magnetically balanced DN; if DRSEP = +1.0 cm, the divertor configuration is biased toward the upper divertor. Three examples are shown in Fig. 1. In the following discussions, VB drift is directed toward the lower divertor

  18. ITER operational space for full plasma current H-mode operation

    Energy Technology Data Exchange (ETDEWEB)

    Mattei, M. [Assoc. Euratom-ENEA-CREATE, Seconda University di Napoli, Aversa (Italy)], E-mail: massimiliano.mattei@unirc.it; Cavinato, M.; Saibene, G.; Portone, A. [Fusion for Energy Joint Undertaking, 08019 Barcelona (Spain); Albanese, R.; Ambrosino, G. [Assoc. Euratom-ENEA-CREATE, University Napoli Federico II, Napoli (Italy); Horton, L.D. [Max Planck-Institut fur Plasmaphysik, EURATOM-Association, Garching (Germany); Kessel, C. [Princeton Plasma Physics Laboratory, Princeton University (United States); Koechl, F. [Assoc. EURATOM-OAW/ATI, Vienna (Austria); Lomas, P.J. [Euratom/UKAEA Fusion Assoc., Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Nunes, I. [Assoc. EURATOM/IST, Centro de Fusao Nuclear, Lisbon (Portugal); Parail, V. [Max Planck-Institut fur Plasmaphysik, EURATOM-Association, Garching (Germany); Sartori, R. [Fusion for Energy Joint Undertaking, 08019 Barcelona (Spain); Sips, A.C.C. [Max Planck-Institut fur Plasmaphysik, EURATOM-Association, Garching (Germany); Thomas, P.R. [Fusion for Energy Joint Undertaking, 08019 Barcelona (Spain)

    2009-06-15

    Sensitivity studies performed as part of the ITER IO design review highlighted a very stiff dependence of the maximum Q attainable on the machine parameters. In particular, in the considered range, the achievable Q scales with I{sub p}{sup 4}. As a consequence, the achievement of the ITER objective of Q = 10 requires the machine to be routinely operated at a nominal current I{sub p} of 15 MA, and at full toroidal field BT of 5.3 T. This paper analyses the capabilities of the poloidal field (PF) system (including the central solenoid) of ITER against realistic full current plasma scenarios. An exploration of the ITER operational space for the 15 and 17 MA inductive scenario is carried out. An extensive analysis includes the evaluation of margins for the closed loop shape control action. The overall results of this analysis indicate that the control of a 15 MA plasma in ITER is likely to be adequate in the range of li 0.7-0.9 whereas, for a 17 MA plasma, control capabilities are strongly reduced. The ITER operational space, provided by the reference pre-2008 PF system, was rather limited if compared to the range of parameters normally observed in present experiment. Proposals for increasing the current and field limits on PF2, PF5 and PF6, adjustment on the number of turns in some of the PF coils, changes to the divertor dome geometry, to the conductor of PF6 to Nb3Sn, moving PF6 radially and/or vertically are described and evaluated in the paper. Some of them have been included in 2008 ITER revised configuration.

  19. Validation of neoclassical bootstrap current models in the edge of an H-mode plasma.

    Science.gov (United States)

    Wade, M R; Murakami, M; Politzer, P A

    2004-06-11

    Analysis of the parallel electric field E(parallel) evolution following an L-H transition in the DIII-D tokamak indicates the generation of a large negative pulse near the edge which propagates inward, indicative of the generation of a noninductive edge current. Modeling indicates that the observed E(parallel) evolution is consistent with a narrow current density peak generated in the plasma edge. Very good quantitative agreement is found between the measured E(parallel) evolution and that expected from neoclassical theory predictions of the bootstrap current.

  20. Direct measurements of the plasma potential in ELMy H-mode plasma with ball-pen probes on ASDEX Upgrade tokamak

    Czech Academy of Sciences Publication Activity Database

    Adámek, Jiří; Stöckel, Jan; Brotánková, Jana; Horáček, Jan; Rohde, V.; Müller, H. W.; Herrmann, A.; Schrittwieser, R.; Mehlmann, F.; Ionita, C.

    390-391, - (2009), s. 1114-1117 ISSN 0022-3115. [International Conference on Plasma-Surface Interactions in Controlled Fusion Device/18th./. Toledo, 26.05.2008-30.05.2008] R&D Projects: GA AV ČR KJB100430601 Institutional research plan: CEZ:AV0Z20430508 Keywords : Edge plasma * Electric field * ELMs * H-mode * ASDEX-Upgrade Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.933, year: 2009 http://dx.doi.org/10.1016/j.jnucmat.2009.01.286

  1. Analysis of performance degradation in an electron heating dominant H-mode plasma after ECRH termination in EAST

    Science.gov (United States)

    Du, Hongfei; Ding, Siye; Chen, Jiale; Wang, Yifeng; Lian, Hui; Xu, Guosheng; Zhai, Xuemei; Liu, Haiqing; Zang, Qing; Lyu, Bo; Duan, Yanmin; Qian, Jinping; Gong, Xianzu

    2018-06-01

    In recent EAST experiments, significant performance degradation accompanied by a decrease of internal inductance is observed in an electron heating dominant H-mode plasma after the electron cyclotron resonance heating termination. The lower hybrid wave (LHW) deposition and effective electron heat diffusivity are calculated to explain this phenomenon. Analysis shows that the changes of LHW heating deposition rather than the increase of transport are responsible for the significant decrease in energy confinement (). The reason why the confinement degradation occurred on a long time scale could be attributed to both good local energy confinement in the core and also the dependence of LHW deposition on the magnetic shear. The electron temperature profile shows weaker stiffness in near axis region where electron heating is dominant, compared to that in large radius region. Unstable electron modes from low to high k in the core plasma have been calculated in the linear GYRO simulations, which qualitatively agree with the experimental observation. This understanding of the plasma performance degradation mechanism will help to find ways of improving the global confinement in the radio-frequency dominant scenario in EAST.

  2. Transport analysis of the edge zone of H-mode plasmas by computer simulation

    International Nuclear Information System (INIS)

    Becker, G.; Murmann, H.

    1988-01-01

    Local transport and ideal ballooning stability in the L-phase and ELM-free H-phase in ASDEX are analysed by computer modelling. It is found that the diffusivities χ e and D at the edge are reduced by a factor of six a few milliseconds after the H-transition. Local transport in the inner plasma improves at an early stage by a typical factor of two. A change in the collisionality regime of electrons and ions does not take place. During the L-phase and the quiescent H-phase ideal ballooning modes are found to be stable. Computer experiments further show that a significant reduction in the particle flux at the separatrix takes place which is closely connected with the H-transition process. This explains the observed buildup of a density shoulder on a millisecond time-scale and the drop of the particle flow into the divertor. A strong decrease of the electron heat conduction flux at the separatrix is, however, ruled out in ELM-free periods. On the assumption of electrostatic turbulence induced transport, these results are consistent with measured density fluctuation levels near the separatrix. (author). 20 refs, 9 figs

  3. Dynamics of the Plasma Edge during the L-H Transition and H-mode in MAST

    Energy Technology Data Exchange (ETDEWEB)

    Scannell, R.; Meyer, H.; Cunningham, G.; Field, A.; Kirk, A.; Samuli, S.; Patel, A., E-mail: rory.scannell@ccfe.ac.uk [EURATOM /CCFE Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Dunai, D.; Zoletnik, S. [KFKI-RMKI, EURATOM Association, Budapest (Hungary)

    2012-09-15

    Full text: The evolution of the MAST plasma during the L-H transition has been studied in the density range 1.5 - 3.0 x 10{sup 19} m{sup -3}. A dithering transition phase, the duration of which depends on the plasma density, is observed before the transition to ELMy or ELM free H-mode. A range of new diagnostic data has been taken during these periods, showing a spin-up of the perpendicular He{sup +} flow correlated with changes in the Da emission. In this density range the power threshold increases with increasing density. As well as the expected power threshold dependency on absolute density, the threshold power is observed to depend on the density evolution prior to the transition. Small changes in fuelling location, plasma current, toroidal field and plasma shape can lead to changes in the power threshold by a factor of two, significantly larger than hose predicted by the scaling. The pedestal evolution between typical type I ELMs in connected double null configuration on MAST show increasing pedestal pressure and width as function time through the ELM cycle. This results in an expanding high pressure gradient region with little increase in peak pressure gradient within this region. It has been shown that the triggering of these ELMs is caused by decreasing stability limit as the transport barrier moves inwards. Application of n = 6 resonant magnetic perturbations to the plasma causes ELM mitigation, with smaller but much more frequent ELMs. The pressure gradients in this mitigated period are significantly less than those observed during non-mitigated type I ELMs. This reduction in pressure gradient, which indicates a different stability limit, results from both a decrease in pedestal height and increase in pedestal width. (author)

  4. High performance deuterium-tritium plasmas in TFTR

    International Nuclear Information System (INIS)

    Sabbagh, S.A.; Bell, M.G.

    1995-03-01

    Plasmas composed of nominally equal concentrations of deuterium and tritium (DT) have been created in TFTR with the goals of producing significant levels of fusion power and of examining the effects of DT fusion alpha particles. Conditioning of the limiter by the injection of lithium pellets has led to an approximate doubling of the energy confinement time, τ E , in supershot plasmas at high plasma current (I p ≤ 2.5 MA) and high heating power (P b ≤ 33 MW). Operation with DT typically results in an additional 20% increase in τ E . In the high poloidal beta, advanced tokamak regime in TFTR, confinement enhancement H triple-bond τ E /τ E ITER-89P > 4 has been obtained in a limiter H-mode configuration at moderate plasma current I p = 0.85 - 1.5 MA. By peaking the plasma current profile, β N dia triple-bond 10 8 tperpendicular > aB 0 /I p = 3 has been obtained in these plasmas, exceeding the β N limit for TFTR plasmas with lower internal inductance, l i . Confinement of alpha particles appears to be classical and losses due to collective effects have not been observed. While small fluctuations in fusion product loss were observed during ELMs, no large loss was detected in DT plasmas

  5. Exploration of the Super H-mode regime on DIII-D and potential advantages for burning plasma devices

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, W. M., E-mail: solomon@fusion.gat.com; Bortolon, A.; Grierson, B. A.; Nazikian, R.; Poli, F. [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States); Snyder, P. B.; Burrell, K. H.; Garofalo, A. M.; Groebner, R. J.; Leonard, A. W.; Meneghini, O.; Osborne, T. H.; Petty, C. C. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Loarte, A. [ITER Organization, Route de Vinon-sur-Verdon - CS 90 046, 13067 St Paul Lez Durance Cedex (France)

    2016-05-15

    A new high pedestal regime (“Super H-mode”) has been predicted and accessed on DIII-D. Super H-mode was first achieved on DIII-D using a quiescent H-mode edge, enabling a smooth trajectory through pedestal parameter space. By exploiting Super H-mode, it has been possible to access high pedestal pressures at high normalized densities. While elimination of Edge localized modes (ELMs) is beneficial for Super H-mode, it may not be a requirement, as recent experiments have maintained high pedestals with ELMs triggered by lithium granule injection. Simulations using TGLF for core transport and the EPED model for the pedestal find that ITER can benefit from the improved performance associated with Super H-mode, with increased values of fusion power and gain possible. Similar studies demonstrate that the Super H-mode pedestal can be advantageous for a steady-state power plant, by providing a path to increasing the bootstrap current while simultaneously reducing the demands on the core physics performance.

  6. Impact of E × B flow shear on turbulence and resulting power fall-off width in H-mode plasmas in experimental advanced superconducting tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Q. Q., E-mail: yangqq@ipp.ac.cn; Zhong, F. C., E-mail: gsxu@ipp.ac.cn, E-mail: fczhong@dhu.edu.cn; Jia, M. N. [College of Science, Donghua University, Shanghai 201620 (China); Xu, G. S., E-mail: gsxu@ipp.ac.cn, E-mail: fczhong@dhu.edu.cn; Wang, L.; Wang, H. Q.; Chen, R.; Yan, N.; Liu, S. C.; Chen, L.; Li, Y. L.; Liu, J. B. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2015-06-15

    The power fall-off width in the H-mode scrape-off layer (SOL) in tokamaks shows a strong inverse dependence on the plasma current, which was noticed by both previous multi-machine scaling work [T. Eich et al., Nucl. Fusion 53, 093031 (2013)] and more recent work [L. Wang et al., Nucl. Fusion 54, 114002 (2014)] on the Experimental Advanced Superconducting Tokamak. To understand the underlying physics, probe measurements of three H-mode discharges with different plasma currents have been studied in this work. The results suggest that a higher plasma current is accompanied by a stronger E×B shear and a shorter radial correlation length of turbulence in the SOL, thus resulting in a narrower power fall-off width. A simple model has also been applied to demonstrate the suppression effect of E×B shear on turbulence in the SOL and shows relatively good agreement with the experimental observations.

  7. Metal impurity transport control in JET H-mode plasmas with central ion cyclotron radiofrequency power injection

    DEFF Research Database (Denmark)

    Valisa, M.; Carraro, L.; Predebon, I.

    2011-01-01

    The scan of ion cyclotron resonant heating (ICRH) power has been used to systematically study the pump out effect of central electron heating on impurities such as Ni and Mo in H-mode low collisionality discharges in JET. The transport parameters of Ni and Mo have been measured by introducing...

  8. Results from core-edge experiments in high Power, high performance plasmas on DIII-D

    Directory of Open Access Journals (Sweden)

    T.W. Petrie

    2017-08-01

    Full Text Available Significant challenges to reducing divertor heat flux in highly powered near-double null divertor (DND hybrid plasmas, while still maintaining both high performance metrics and low enough density for application of RF heating, are identified. For these DNDs on DIII-D, the scaling of the peak heat flux at the outer target (q⊥P ∝ [PSOL x IP] 0.92 for PSOL= 8−19MW and IP= 1.0–1.4MA, and is consistent with standard ITPA scaling for single-null H-mode plasmas. Two divertor heat flux reduction methods were tested. First, applying the puff-and-pump radiating divertor to DIII-D plasmas may be problematical at high power and H98 (≥ 1.5 due to improvement in confinement time with deuterium gas puffing which can lead to unacceptably high core density under certain conditions. Second, q⊥P for these high performance DNDs was reduced by ≈35% when an open divertor is closed on the common flux side of the outer divertor target (“semi-slot” but also that heating near the slot opening is a significant source for impurity contamination of the core.

  9. Physics of high performance JET plasmas in D-T

    International Nuclear Information System (INIS)

    2001-01-01

    JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB ''Gas Box'' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling ''Wind Tunnel'' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in

  10. Physics of high performance jet plasmas in D-T

    International Nuclear Information System (INIS)

    1999-01-01

    JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB 'Gas Box' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling 'Wind Tunnel' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in such

  11. Electron Bernstein wave heating of over-dense H-mode plasmas in the TCV tokamak via O-X-B double mode conversion

    International Nuclear Information System (INIS)

    Pochelon, A.; Mueck, A.; Curchod, L.; Camenen, Y.; Coda, S.; Duval, B.P.; Goodman, T.P.; Klimanov, I.; Laqua, H.P.; Martin, Y.; Moret, J.-M.; Porte, L.; Sushkov, A.; Udintsev, V.S.; Volpe, F.

    2007-01-01

    This paper reports on the first demonstration of electron Bernstein wave heating (EBWH) by double mode conversion from ordinary (O-) to Bernstein (B-) via the extraordinary (X-) mode in an over-dense tokamak plasma, using low field side launch, achieved in the TCV tokamak H-mode, making use of its naturally generated steep density gradient. This technique offers the possibility of overcoming the upper density limit of conventional EC microwave heating. The sensitive dependence of the O-X mode conversion on the microwave launching direction has been verified experimentally. Localized power deposition, consistent with theoretical predictions, has been observed at densities well above the conventional cut-off. Central heating has been achieved, at powers up to two megawatts. This demonstrates the potential of EBW in tokamak H-modes, the intended mode of operation for a reactor such as ITER

  12. Low-n magnetohydrodynamic edge instabilities in quiescent H-mode plasmas with a safety-factor plateau

    International Nuclear Information System (INIS)

    Zheng, L.J.; Kotschenreuther, M.T.; Valanju, P.

    2013-01-01

    Low-n magnetohydrodynamic (MHD) modes in the quiescent high confinement mode (H-mode) pedestal are investigated in this paper. Here, n is the toroidal mode number. The low collisionality regime is considered, so that a safety-factor plateau arises in the pedestal region because of the strong bootstrap current. The JET-like (Joint European Torus) equilibria of quiescent H-mode discharges are generated numerically using the VMEC code. The stability of this type of equilibria is analysed using the AEGIS code, with subsonic rotation effects taken into account. The current investigation extends the previous studies of n = 1 modes to n = 2 and 3 modes. The numerical results show that the MHD instabilities in this type of equilibria have characteristic features of the infernal mode. We find that this type of mode tends to prevail when the safety-factor value in the shear-free region is slightly larger than an integer. In this case the frequencies (ω n ) of modes with toroidal mode number n roughly follow the rule ω n ∼ −nΩ p , where Ω p is the local rotation frequency where the infernal harmonic prevails. Since the infernal mode tends to develop near the pedestal top, where pressure driving is strong but magnetic shear stabilization is weak, this local rotation frequency tends to be close to the pedestal top value. These typical mode features bear close resemblance to the edge harmonic oscillations (or outer modes) at the quiescent H-mode discharges observed experimentally. (paper)

  13. High performance liquid chromatographic determination of glucosamine in rat plasma.

    Science.gov (United States)

    Aghazadeh-Habashi, Ali; Sattari, Saeed; Pasutto, Franco; Jamali, Fakhreddin

    2002-01-01

    A high performance liquid chromatographic method was developed for the determination of glucosamine (GlcN) in rat plasma. Internal standard, galactosamine, was added to 100 micro L of plasma containing GlcN followed by precipitation of plasma proteins with acetonitrile. Evaporation of the decanted supernatant solution was accelerated by the addition of methanol. GlcN was derivatized by addition of a solution containing 1-naphthyl isothiocyanate. Sample cleanup included passage through an anion exchange cartridge. Analysis was accomplished by injection of 0.1 mL of the sample solution into an isocratic HPLC system consisting of a C18 column, a mobile phase of acetonitrile: water: acetic acid: triethylamine (4.5: 95.5:0.1:0.05), a flow rate of 0.9 mL/min, and a UV detector set at 254 nm. Galactosamine and GlcN appeared 26 and 29 min post-injection, respectively. The assay was linear over the range of 1.25-400 micro g/mL (CV<10%) with a detection limit of 0.63 microg/mL and a limit of quantification of 1.25 microg/mL. The method was applied to the determination of GlcN in rat plasma after oral administration of 350 mg/kg of GlcN hydrochloride. The present assay is specific, sensitive, precise, and accurate and is suitable for pharmacokinetic studies.

  14. Drift-based Model for Power Scrape-off Width in Low-Gas-Puff H-mode Plasmas: Theory and Implications

    Energy Technology Data Exchange (ETDEWEB)

    Goldston, R., E-mail: rgoldston@pppl.gov [Princeton Plasma Physics Laboratory, Princeton (United States)

    2012-09-15

    Full text: A heuristic model for the plasma scrape-off width in low-gas-puff tokamak H-mode plasmas is introduced. {nabla}B and curvature drifts into the scrape-off layer (SOL) are balanced against near-sonic parallel flows out of the SOL, to the divertor plates. These assumptions result in an estimated SOL width of order the poloidal gyroradius. It is next assumed that anomalous perpendicular electron thermal diffusivity is the dominant source of heat flux across the separatrix, investing the SOL width, derived above, with heat from the main plasma. The separatrix temperature is then calculated based on a two-point model balancing power input to the SOL with Spitzer-Hiarm parallel thermal conduction losses to the divertor. This results in a heuristic closed-form prediction for the power scrape-off width that is in quantitative agreement both in absolute magnitude and in scaling with recent experimental data. The applicability of the Spitzer-Harm model to this regime can be questioned at the lowest densities, where the presence of a sheath can raise the divertor target electron temperature. A more general two-point model including a finite ratio of divertor target to upstream electron temperature shows only a 5% effect on the SOL width with target temperature f{sub T} = 75% of upstream, so this effect is likely negligible in experimentally relevant regimes. To achieve the near-sonic flows measured experimentally, and assumed in this model, sets requirements on the ratio of upstream to total SOL particle sources relative to the square-root of the ratio of target to upstream temperature. As a result very high recycling regimes may allow significantly wider power fluxes. The Pfisch-Schluter model for equilibrium flows has been modified to allow near-sonic flows, appropriate for gradient scale lengths of order the poloidal gyroradius. This results in a new quadrupole flow pattern that amplifies the usual P-S flows at the outer midplane, while reducing them at the inner

  15. Three-dimensional simulation of H-mode plasmas with localized divertor impurity injection on Alcator C-Mod using the edge transport code EMC3-EIRENE

    International Nuclear Information System (INIS)

    Lore, J. D.; Reinke, M. L.; Lipschultz, B.; Brunner, D.; LaBombard, B.; Terry, J.; Pitts, R. A.; Feng, Y.

    2015-01-01

    Experiments in Alcator C-Mod to assess the level of toroidal asymmetry in divertor conditions resulting from poloidally and toroidally localized extrinsic impurity gas seeding show a weak toroidal peaking (∼1.1) in divertor electron temperatures for high-power enhanced D-alpha H-mode plasmas. This is in contrast to similar experiments in Ohmically heated L-mode plasmas, which showed a clear toroidal modulation in the divertor electron temperature. Modeling of these experiments using the 3D edge transport code EMC3-EIRENE [Y. Feng et al., J. Nucl. Mater. 241, 930 (1997)] qualitatively reproduces these trends, and indicates that the different response in the simulations is due to the ionization location of the injected nitrogen. Low electron temperatures in the private flux region (PFR) in L-mode result in a PFR plasma that is nearly transparent to neutral nitrogen, while in H-mode the impurities are ionized in close proximity to the injection location, with this latter case yielding a largely axisymmetric radiation pattern in the scrape-off-layer. The consequences for the ITER gas injection system are discussed. Quantitative agreement with the experiment is lacking in some areas, suggesting potential areas for improving the physics model in EMC3-EIRENE

  16. Modification of adhered dust on plasma-facing surfaces due to exposure to ELMy H-mode plasma in DIII-D

    Directory of Open Access Journals (Sweden)

    I. Bykov

    2017-08-01

    Full Text Available Transient heat load tests have been conducted in the lower divertor of DIII-D using DiMES manipulator in order to study the behavior of dust on tungsten Plasma Facing Components (PFCs during ELMy H-mode discharges. Samples with pre-adhered, pre-characterized dust have been exposed at the outer strike point (OSP in a series of discharges with varied intra-(inter- ELM heat fluxes. We used C dust because of its high sublimation temperature and non-metal properties. Al dust as a surrogate for Be and W dust were employed as relevant to that in the ITER divertor. The poor initial thermal contact between the substrate and the particles led to overheating, sublimation and shrinking of the carbon dust, and wetting induced coagulation of Al dust. Little modification of the W dust was observed. An enhanced surface adhesion and improvement of the thermal contact of C and Al dust were the result of exposure. A post mortem “adhesive tape” sampling showed that 70% of Al, <5% of W and C particles could not be removed from the surface owing to the improved adhesion. Al and C but not W particles that could be lifted had W inclusions indicating damage to the substrate. This suggests that non destructive methods may be inefficient for removal of dust in ITER.

  17. High-performance liquid chromatographic radioenzymatic assay for plasma catecyholamines

    International Nuclear Information System (INIS)

    Klaniecki, T.S.; Corder, C.N.; McDonald, R.H. Jr.; Feldman, J.A.

    1977-01-01

    A new assay method for plasma catecholamimes (CA) requiring only 50 μl has been developed, which uses high performance liquid chromatography (HPLC). The norepinephrine (NE), dopamine (D), and epinephrine (E) compounds found in plasma are radioactively o-methylated with S-[methyl- 3 H]-adenosyl-L-methionine ( 3 H-SAM) 3 H-SAM by the reaction of catechol-o-methyl transferase (COMT). The reaction is terminated and a standard mixture of nonradioactive o-methylated analogues of NE, D, and E is added to act as a carrier. Following separation by HPLC, the D,L-normetanephrine (NMN), 3-methoxy-4-hydroxyphenylethyl-amine or 3-methoxytyramine (3-MOT), and metanephrine (MN) radioactive peaks are collected which represent NE, D, and E, respectively. Then MNM and MN are oxidized to vanillin, and 3-MOT is acetylated. The products are subsequently separated by solvent extraction. This is necessary in order to avoid high radioactive blanks and to allow quantitation of the radioactivity by liquid scintillation spectrometry. The mean supine levels of NE, D, and E in normal subjects were respectively 182, 33, and 87 pg/ml of plasma. Similar assays on patients with pheochromocytoma revealed 797, 80, and 470 pg/ml

  18. Comparing 1.5D ONETWO and 2D SOLPS analyses of inter-ELM H-mode plasma in DIII-D

    International Nuclear Information System (INIS)

    Owen, Larry W.; Canik, John; Groebner, R.; Callen, J.D.; Bonnin, X.; Osborne, T.H.

    2010-01-01

    A DIII-D inter-ELM H-mode plasma that is in approximate transport equilibrium is analysed with the 1.5D ONETWO core code and the 2D SOLPS code. In order to investigate the importance of core-edge coupling and 2D effects, including divertor fuelling across the X-point and poloidal asymmetries that are not explicitly included in ONETWO, the domain of SOLPS is extended to very near the magnetic axis. Two principal objectives are (1) to determine whether poloidal asymmetries in the plasma distributions are large enough to vitiate a core-type interpretive plasma transport analysis and (2) to determine whether the interpretive transport coefficients and neutral beam power and particle sources from ONETWO, when used in 2D SOLPS full plasma simulations, yield the same quality fits to the measured upstream density and temperature profiles as obtained with ONETWO. Results show that only a small increase in the separatrix value of the particle diffusion coefficient, and no change in the thermal diffusivities from ONETWO was needed to get excellent agreement of the upstream SOLPS density and temperature profiles and the Thomson scattering and CER data. Good agreement of the ONETWO and SOLPS flux surface averaged distributions of the core electron and D+ densities and temperatures are also obtained. Likewise the C6+ density, with a simple chemical sputtering model based on a constant fraction of the divertor D+ flux, the core heat and particle fluxes and the neutral density reveal no 2D effects in the core/pedestal region that would vitiate a 1.5D treatment of the inter-ELM H-mode plasma.

  19. Progress Toward Long Pulse, High Performance Plasmas in the DIII-D Tokamak

    International Nuclear Information System (INIS)

    P.A. Politzer; T.C. Luce; M.E. Austin; J.R. Ferron, A.M. Garofalo; C.M. Greenfield; A.W. Hyatt; R.J. La Haye; L.L. Lao; E.A. Lazarus; M.A. Makowski; M. Murakami; C.C. Petty; R.I. Pinsker; B.W. Rice; E.J. Strait, M.R. Wade; J.G. Watkins

    2000-01-01

    A major portion of the research program of the DIII-D tokamak collaboration is devoted to the development and demonstration of high performance advanced tokamak plasmas, with profiles as close as possible to those anticipated for steady-state operation. The work during the 1999 campaign has resulted in significant progress toward this goal. High normalized performance ((beta)(sub N)(approx) 4 and(beta)(sub N) H(sub 89)(approx) 9) discharges have been sustained for up to 2 s. These plasmas are in H-mode with rapid ELMs. The most common limiting phenomena are resistive wall modes (RWMs) rather than neoclassical tearing modes (NTMs). NTMs do occur, apparently triggered by the RWMs. The observed pressure is well above the calculated beta limit without a wall, and(beta)(sub N) and gt; 4(ell)(sub i) throughout the high performance phase. The bootstrap current is estimated to be and gt;50% of the total, and measurements of the internal loop voltage show that only about 25% of the current is inductively driven. The central q profile is flat, as is the calculated bootstrap current profile, due to the absence of any localized pressure gradients. The residual inductive current is localized around r/a(approx) 0.5. To demonstrate quasi-stationary operation, it will be necessary to replace the residual inductive current with ECCD at the same minor radius. To effectively apply ECH and ECCD to these discharges, density control will be needed. Preliminary experiments using the DIII-D cryopump have reduced the density by(approx)20%. A new EC power system and a new private flux cryopump will be available for the 2000 campaign

  20. H-mode study in CHS

    International Nuclear Information System (INIS)

    Toi, K.; Morisaki, T.; Sakakibara, S.

    1995-02-01

    In CHS rapid H-mode transition is observed in NBI heated deuterium and hydrogen plasmas without obvious isotope effect, when a net plasma current is ramped up to increase the external rotational transform. The H-mode of CHS has many similarities with those in tokamaks. Recent measurement with fast response Langmuir probes has revealed that the rapid change in floating potential occurs at the transition, but the change follows the formation of edge transport barrier. The presence of ι/2π = 1 surface near the edge and sawtooth crash triggered by internal modes may play an important role for determining the H-mode transition in CHS. (author)

  1. Detailed study of spontaneous rotation generation in diverted H-mode plasma using the full-f gyrokinetic code XGC1

    Science.gov (United States)

    Seo, Janghoon; Chang, C. S.; Ku, S.; Kwon, J. M.; Yoon, E. S.

    2013-10-01

    The Full-f gyrokinetic code XGC1 is used to study the details of toroidal momentum generation in H-mode plasma. Diverted DIII-D geometry is used, with Monte Carlo neutral particles that are recycled at the limiter wall. Nonlinear Coulomb collisions conserve particle, momentum, and energy. Gyrokinetic ions and adiabatic electrons are used in the present simulation to include the effects from ion gyrokinetic turbulence and neoclassical physics, under self-consistent radial electric field generation. Ion orbit loss physics is automatically included. Simulations show a strong co-Ip flow in the H-mode layer at outside midplane, similarly to the experimental observation from DIII-D and ASDEX-U. The co-Ip flow in the edge propagates inward into core. It is found that the strong co-Ip flow generation is mostly from neoclassical physics. On the other hand, the inward momentum transport is from turbulence physics, consistently with the theory of residual stress from symmetry breaking. Therefore, interaction between the neoclassical and turbulence physics is a key factor in the spontaneous momentum generation.

  2. Influence of gas puff location on the coupling of lower hybrid waves in JET ELMy H-mode plasmas

    Czech Academy of Sciences Publication Activity Database

    Ekedahl, A.; Petržílka, Václav; Baranov, Y.; Biewer, T.M.; Brix, M.; Goniche, M.; Jacquet, P.; Kirov, K.K.; Klepper, C.C.; Mailloux, J.; Mayoral, M.-L.; Nave, M.F.F.; Ongena, J.; Rachlew, E.

    2012-01-01

    Roč. 54, č. 7 (2012), 074004-074004 ISSN 0741-3335. [IAEA Fusion Energy Conference 2010/23./. Daejeon, 11.10.2010-16.10.2010] R&D Projects: GA ČR GA202/07/0044; GA ČR GAP205/10/2055; GA MŠk(CZ) LG11018 Institutional research plan: CEZ:AV0Z20430508 Keywords : LH wave * plasma * current drive * tokamak * LHCD Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.369, year: 2012 http://iopscience.iop.org/0741-3335/54/7/074004/pdf/0741-3335_54_7_074004.pdf

  3. Plasma dynamics with second and third-harmonic ECRH and access to quasi-stationary ELM-free H-mode on TCV

    International Nuclear Information System (INIS)

    Porte, L.; Coda, S.; Alberti, S.; Arnoux, G.; Blanchard, P.; Bortolon, A.; Fasoli, A.; Goodman, T.P.; Klimanov, Y.; Martin, Y.; Maslov, M.; Scarabosio, A.; Weisen, H.

    2007-01-01

    Intense electron cyclotron resonance heating (ECRH) and electron cyclotron current drive (ECCD) are employed on the Tokamak a Configuration Variable (TCV) both in second- and third-harmonic X-mode (X2 and X3). The plasma behaviour under such conditions is driven largely by the electron dynamics, motivating extensive studies of the heating and relaxation phenomena governing both the thermal and suprathermal electron populations. In particular, the dynamics of suprathermal electrons are intimately tied to the physics of X2 ECCD. ECRH is also a useful tool for manipulating the electron distribution function in both physical and velocity space. Fundamental studies of the energetic electron dynamics have been performed using periodic, low-duty-cycle bursts of ECRH, with negligible average power injection, and with electron cyclotron emission (ECE). The characteristic times of the dynamical evolution are clearly revealed. Suprathermal electrons have also been shown to affect the absorption of X3 radiation. Thermal electrons play a crucial role in high density plasmas where indirect ion heating can be achieved through ion-electron collisions. In recent experiments ∼ 1.35 MW of vertically launched X3 ECRH was coupled to a diverted ELMy H-mode plasma. In cases where ≥ 1.1 MW of ECRH power was coupled, the discharge was able to transition into a quasi-stationary ELM-free H-mode regime. These H-modes operated at β N ∼ 2, n-bar e /n G approx. 0.25 and had high energy confinement, H IPB98(y,2) up to ∼ 1.6. Despite being purely electron heated and having no net particle source these discharges maintained a density peaking factor (n e,o /(n e ) ∼ 1.6). They also exhibited spontaneous toroidal momentum production in the co-current direction. The momentum production is due to a transport process as there is no external momentum input. This process supports little or no radial gradient of the toroidal velocity

  4. Studies of Turbulence and Transport in Alcator C-Mod H-Mode Plasmas with Phase Contrast Imaging and Comparisons with GYRO

    Science.gov (United States)

    Porkolab, M.; Lin, L.; Edlund, E. M.; Rost, J. C.; Fiore, C. L.; Greenwald, M.; Mikkelsen, D.

    2008-11-01

    We present recent experimental measurements of turbulence and transport in C-Mod H-Mode plasmas with and without internal transport barriers (ITB) using the phase contrast imaging (PCI) diagnostic and compare the results with GYRO predictions. In plasmas without ITB, the fluctuation above 300 kHz observed by PCI agrees with ITG in GYRO simulation, including the direction of propagation, wavenumber spectrum, and absolute intensity within experimental uncertainly (+/-75%). After transition to ITBs, the observed overall fluctuation intensity increases. GYRO simulation in the core shows that ITG dominates in ITBs but its intensity is lower than the overall experimental measurements which may also include contributions from the plasma edge. These results, as well as the impact of varying ∇Ti, ∇n, and ExB shear on turbulence will be discussed. C.L. Fiore et al., Fusion Sci. Technol., 51, 303 (2007). M. Porkolab et al., IEEE Trans. Plasma Sci. 34, 229 (2006). J. Candy et al., Phys. Rev. Lett., 91, 045001 (2003).

  5. The H-mode of ASDEX

    International Nuclear Information System (INIS)

    1989-01-01

    The paper is a review of investigations of the H-mode on ASDEX performed since its discovery in 1982. The topics discussed are: (1) the development of the plasma profiles, with steep gradients in the edge region and flat profiles in the bulk plasma, (2) the MHD properties resulting from the profile changes, including an extensive stability analysis, (3) the impurity development, with special emphasis on the MHD aspects and on neoclassical impurity transport effects in quiescent H-phases, and (4) the properties of the edge plasma, including the evidence of three-dimensional distortions at the edge. The part on confinement includes scaling studies and the results of transport analysis. The power threshold of the H-mode is found to depend weakly on the density, but there is probably no dependence on the toroidal field or the current. For the operational range of the H-mode, new results for the limiter H-mode on ASDEX and the development of the H-mode under beam current drive conditions are included. A number of experiments are described which demonstrate the crucial role of the edge electron temperature in the L-H transition. New results of magnetic and density fluctuation studies at the plasma edge within the edge transport barrier are presented. Finally, the findings on ASDEX are compared with results obtained on other machines and are used to test various H-mode theories. (author). 131 refs, 103 figs, 1 tab

  6. Discovery of stationary operation of quiescent H-mode plasmas with net-zero neutral beam injection torque and high energy confinement on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Burrell, K. H.; Chen, X.; Garofalo, A. M.; Groebner, R. J.; Muscatello, C. M.; Osborne, T. H.; Petty, C. C.; Snyder, P. B. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Barada, K.; Rhodes, T. L.; Zeng, L. [University of California-Los Angeles, Los Angeles, California 90024 (United States); Solomon, W. M. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States); Yan, Z. [University of Wisconsin-Madison, Madison, Wisconsin 53706 (United States)

    2016-05-15

    Recent experiments in DIII-D [J. L. Luxon et al., in Plasma Physics and Controlled Nuclear Fusion Research 1996 (International Atomic Energy Agency, Vienna, 1987), Vol. I, p. 159] have led to the discovery of a means of modifying edge turbulence to achieve stationary, high confinement operation without Edge Localized Mode (ELM) instabilities and with no net external torque input. Eliminating the ELM-induced heat bursts and controlling plasma stability at low rotation represent two of the great challenges for fusion energy. By exploiting edge turbulence in a novel manner, we achieved excellent tokamak performance, well above the H{sub 98y2} international tokamak energy confinement scaling (H{sub 98y2} = 1.25), thus meeting an additional confinement challenge that is usually difficult at low torque. The new regime is triggered in double null plasmas by ramping the injected torque to zero and then maintaining it there. This lowers E × B rotation shear in the plasma edge, allowing low-k, broadband, electromagnetic turbulence to increase. In the H-mode edge, a narrow transport barrier usually grows until MHD instability (a peeling ballooning mode) leads to the ELM heat burst. However, the increased turbulence reduces the pressure gradient, allowing the development of a broader and thus higher transport barrier. A 60% increase in pedestal pressure and 40% increase in energy confinement result. An increase in the E × B shearing rate inside of the edge pedestal is a key factor in the confinement increase. Strong double-null plasma shaping raises the threshold for the ELM instability, allowing the plasma to reach a transport-limited state near but below the explosive ELM stability boundary. The resulting plasmas have burning-plasma-relevant β{sub N} = 1.6–1.8 and run without the need for extra torque from 3D magnetic fields. To date, stationary conditions have been produced for 2 s or 12 energy confinement times, limited only by external hardware constraints

  7. Controllers for high-performance nuclear fusion plasmas

    NARCIS (Netherlands)

    Baar, de M.R.

    2012-01-01

    A succesful nuclear fusion reactor will confine plasma at hig temperatures and densities, with low thermal losses. The workhorse of the nuclear fusion community is the tokamak, a toroidal device in which plasmas are confined by poloidal and toroidal magnetic fields. Ideally, the confirming magnetic

  8. Physics of high performance deuterium-tritium plasmas in TFTR

    International Nuclear Information System (INIS)

    McGuire, K.M.; Batha, S.

    1996-11-01

    During the past two years, deuterium-tritium (D-T) plasmas in the Tokamak Fusion Test Reactor (TFTR) have been used to study fusion power production, isotope effects associated with tritium fueling, and alpha-particle physics in several operational regimes. The peak fusion power has been increased to 10.7 MW in the supershot mode through the use of increased plasma current and toroidal magnetic field and extensive lithium wall conditioning. The high-internal-inductance (high-I i ) regime in TFTR has been extended in plasma current and has achieved 8.7 MW of fusion power. Studies of the effects of tritium on confinement have now been carried out in ohmic, NBI- and ICRF- heated L-mode and reversed-shear plasmas. In general, there is an enhancement in confinement time in D-T plasmas which is most pronounced in supershot and high-I i discharges, weaker in L-mode plasmas with NBI and ICRF heating and smaller still in ohmic plasmas. In reversed-shear discharges with sufficient deuterium-NBI heating power, internal transport barriers have been observed to form, leading to enhanced confinement. Large decreases in the ion heat conductivity and particle transport are inferred within the transport barrier. It appears that higher heating power is required to trigger the formation of a transport barrier with D-T NBI and the isotope effect on energy confinement is nearly absent in these enhanced reverse-shear plasmas. Many alpha-particle physics issues have been studied in the various operating regimes including confinement of the alpha particles, their redistribution by sawteeth, and their loss due to MHD instabilities with low toroidal mode numbers. In weak-shear plasmas, alpha-particle destabilization of a toroidal Alfven eigenmode has been observed

  9. Limiter H-mode experiments on TFTR

    Energy Technology Data Exchange (ETDEWEB)

    Bush, C [Oak Ridge National Lab., TN (USA); Bretz, N L; Fredrickson, E D; McGuire, K M; Nazikian, R; Park, H K; Schivell, J; Taylor, G; Bitter, B; Budny, R; Cohen, S A; Kilpatrick, S J; LeBlanc, B; Manos, D M; Meade, D; Paul, S F; Scott, S D; Stratton, B C; Synakowski, E J; Towner, H H; Weiland, R M; Arunasalam, V; Bateman, G; Bell, M G; Bell, R; Boivin, R; Cavallo, A; Cheng, C Z; Chu, T K; Cowl,

    1990-12-15

    Limiter H-modes with centrally peaked density profiles have been obtained in TFTR using a highly conditioned graphite limiter. The transition to these centrally peaked H-modes takes place from the supershot to the H-mode rather than the usual L- to H-mode transition observed on other tokamaks. Bi-directional beam heating is required to induce the transition. Density peaking factors, n{sub e}(0)/{l angle}n{sub e}{r angle}, >2.3 are obtained and at the same time the H-mode characteristics are similar to those of limiter H-modes on other tokamaks and the global confinement, {tau}{sub E}, can be >2.5 times L-mode scaling. The TRANSP analysis shows that transport in these H-modes is similar to that of supershots within the inner 60 cm of the plasma, but the stored electron energy (calculated using measured values of T{sub e} and n{sub e}) is higher for the H-mode at the plasma edge. Microwave scattering near the edge shows broad spectra at k = 5.5 cm{sup {minus}1} which begin at the drop in D{sub {alpha}} radiation and are strongly shifted in the electron diamagnetic drift direction. At the same time beam emission spectroscopy shows a coherent mode near the boundary with m = 15--20 at 20--30 kHz which is propagating in the ion direction. During an ELM event these apparent rotations cease and Mirnov fluctuations in the 50--500 kHz increase in intensity.

  10. ELMs and the H-mode pedestal in NSTX

    International Nuclear Information System (INIS)

    Maingi, R.; Sabbagh, S.A.; Bush, C.E.; Fredrickson, E.D.; Menard, J.E.; Stutman, D.; Tritz, K.; Bell, M.G.; Bell, R.E.; Boedo, J.A.; Gates, D.A.; Johnson, D.W.; Kaita, R.; Kaye, S.M.; Kugel, H.W.; LeBlanc, B.P.; Mueller, D.; Raman, R.; Roquemore, A.L.; Soukhanovskii, V.A.; Stevenson, T.

    2005-01-01

    We report on the behavior of ELMs in NBI-heated H-mode plasmas in NSTX. It is observed that the size of Type I ELMs, characterized by the change in plasma energy, decreases with increasing line-average density, as observed at conventional aspect ratio. It is also observed that the Type I ELM size decreases as the plasma equilibrium is shifted from a symmetric double-null toward a lower single-null configuration. Type II/III ELMs have also been observed in NSTX, as well as a high-performance regime with small ELMs which we designate Type V. The Type V ELMs are characterized by an intermittent n 1 magnetic pre-cursor oscillation rotating counter to the plasma current; the mode vanishes between Type V ELMs crashes. Without active pumping, the density rises continuously through the Type V phase, albeit at a slower rate than ELM-free discharges

  11. Physics of the H-mode

    International Nuclear Information System (INIS)

    Hinton, F.L.; Chu, M.S.; Dominguez, R.R.

    1985-01-01

    A theoretical picture of the H-mode is proposed which explains some of the most important features of this good confinement mode in neutral beam heated plasmas with divertors. From consideration of the transport through the separatrix and along the open field lines outside the separatrix, as well as the stability of the plasma inside the separatrix, we show that a bifurcation in the operating parameters is possible. At high edge temperatures, very large particle confinement times are possible because of the Ware pinch. The transport of particles and heat along the open field lines to the divertor region depends on temperature in a non-monotonic way, and the bifurcation of the thermal equilibrium which is implied may correspond to the L- to H-mode transition. The improvement of the interior confinement in the H-mode, when the edge temperature is higher, is shown to follow from the tearing mode stability properties of current profiles with pedestals. (author)

  12. L to H-mode Power Threshold and Confinement Characteristics of H-modes in KSTAR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. S.; Na, Y.S., E-mail: ftwalker.hyuns@gmail.com [Seoul National University, Seoul (Korea, Republic of); Ahn, J. W. [Oak Ridge National Laboratory, Oak Ridge (United States); Jeon, Y. M.; Yoon, S. W.; Lee, K. D.; Ko, W. H.; Bae, Y. S.; Kim, W. C.; Kwak, J. G. [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2012-09-15

    Full text: Since KSTAR has obtained the H-mode in 2010 campaign, H-mode plasmas were routinely obtained with combined heating of NBI with maximum power of 1.5 MW and ECRH with maximum power of {approx} 0.3 MW and {approx} 0.6 MW for 110 GHz and 170 GHz, respectively. The L- to H-mode power threshold and confinement properties of KSTAR H-modes are investigated in this work. Firstly, the L- to H-mode power threshold and the power loss to the seperatrix are calculated by power balance analysis for about collected 400 shots. As a result, a trend of roll-over is observed in the power threshold of KSTAR H-mode compared with the multi-machine power threshold scaling in the low density regime. Dependence of the power threshold on other parameters are also investigated such as the X-point position and shaping parameters like as triangularity and elongation. In addition, the reason of reduction of power threshold in 2011 campaign compared with that in 2010 is addressed. Secondly, the confinement enhancement factors are calculated to evaluate the performance of KSTAR H-modes. The calculated H{sub 89-p} and H{sub 98} (y, 2) represent that the confinement is enhanced in most KSTAR H-mode discharges. Interestingly, even in L-mode phases, confinement is observed to be enhanced against the multi-machine scalings. H{sub exp} factor is newly introduced to evaluate the amount of confinement improvement in the H-mode phase compared with the L-mode phase in a single discharge. H{sub exp} exhibits that the global energy confinement time of the H-mode phase is improved about 1.3 - 2.0 times compared with that of the L-mode phase. Finally, interpretive and predictive numerical simulations are carried out using the ASTRA code for typical KSTAR H-mode discharges. The Weiland model and the GLF23 model are employed for calculating the anomalous contributions of both electron and ion heat transport in predictive simulations. For the H-mode phase, the Weiland model reproduces the experiment

  13. Mixed-Language High-Performance Computing for Plasma Simulations

    Directory of Open Access Journals (Sweden)

    Quanming Lu

    2003-01-01

    Full Text Available Java is receiving increasing attention as the most popular platform for distributed computing. However, programmers are still reluctant to embrace Java as a tool for writing scientific and engineering applications due to its still noticeable performance drawbacks compared with other programming languages such as Fortran or C. In this paper, we present a hybrid Java/Fortran implementation of a parallel particle-in-cell (PIC algorithm for plasma simulations. In our approach, the time-consuming components of this application are designed and implemented as Fortran subroutines, while less calculation-intensive components usually involved in building the user interface are written in Java. The two types of software modules have been glued together using the Java native interface (JNI. Our mixed-language PIC code was tested and its performance compared with pure Java and Fortran versions of the same algorithm on a Sun E6500 SMP system and a Linux cluster of Pentium~III machines.

  14. Optimization and Control of Burning Plasmas Through High Performance Computing

    Energy Technology Data Exchange (ETDEWEB)

    Pankin, Alexei [Tech-X Corporation, Boulder, CO (United States)

    2017-12-18

    This project has revived the FACETS code, that has been developed under SciDAC fund- ing in 2008-2012. The code has been dormant for a number of years after the SciDAC funding stopped. FACETS depends on external packages. The external packages and libraries such as PETSc, FFTW, HDF5 and NETCDF that are included in FACETS have evolved during these years. Some packages in FACETS are also parts of other codes such as PlasmaState, NUBEAM, GACODES, and UEDGE. These packages have been also evolved together with their host codes which include TRANSP, TGYRO and XPTOR. Finally, there is also a set of packages in FACETS that are being developed and maintained by Tech-X. These packages include BILDER, SciMake, and FcioWrappers. Many of these packages evolved significantly during the last several years and FACETS had to be updated to synchronize with the re- cent progress in the external packages. The PI has introduced new changes to the BILDER package to support the updated interfaces to the external modules. During the last year of the project, the FACETS version of the UEDGE code has been extracted from FACETS as a standalone package. The PI collaborates with the scientists from LLNL on the updated UEDGE model in FACETS. Drs. T. Rognlien, M. Umansky and A. Dimits from LLNL are contributing to this task.

  15. H-modes studies in PDX

    International Nuclear Information System (INIS)

    Fonck, R.J.; Beirsdorfer, P.; Bell, M.

    1984-07-01

    A regime of enhanced energy confinement during neutral beam heating has been obtained routinely in the PDX tokamak after modifications to form a closed divertor geometry. Plasma density profiles were broad and the electron temperature at the plasma edge reached values of approx. 400 eV in the H-mode phase of a discharge. A comparison of closed divertor discharges with moderate and intense gas puffing indicates that a requirement for obtaining high confinement times is the localization of the plasma fueling source in the divertor throat region. While high confinement was attained at moderate injected powers (P/sub INJ/ less than or equal to 3 MW), confinement was degraded at higher powers due to both increased edge instabilities and, especially, the intense gas puffing needed to prevent disruptions. Initial results with a particle scoop limiter indicate high particle confinement times and energy confinement times approaching those of diverted H-mode plasmas

  16. Determination of trimethyllead reference material using high performance liquid chromatography-inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Lu Hai; Wei Chao; Wang Jun; Chao Jingbo; Zhou Tao; Chen Dazhou

    2005-01-01

    A high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) was combined, and the chromatography conditions were optimized. The stability and homogeneity of a trimethyllead reference material were determined using this method. (authors)

  17. Investigation into the formation of the scrape-off layer density shoulder in JET ITER-like wall L-mode and H-mode plasmas

    Science.gov (United States)

    Wynn, A.; Lipschultz, B.; Cziegler, I.; Harrison, J.; Jaervinen, A.; Matthews, G. F.; Schmitz, J.; Tal, B.; Brix, M.; Guillemaut, C.; Frigione, D.; Huber, A.; Joffrin, E.; Kruzei, U.; Militello, F.; Nielsen, A.; Walkden, N. R.; Wiesen, S.; Contributors, JET

    2018-05-01

    The low temperature boundary layer plasma (scrape-off layer or SOL) between the hot core and the surrounding vessel determines the level of power loading, erosion and implantation of material surfaces, and thus the viability of tokamak-based fusion as an energy source. This study explores mechanisms affecting the formation of flattened density profiles, so-called ‘density shoulders’, in the low-field side (LFS) SOL, which modify ion and neutral fluxes to surfaces—and subsequent erosion. We find that increases in SOL parallel resistivity, Λdiv (=[L || ν eiΩi]/c sΩe), postulated to lead to shoulder growth through changes in SOL turbulence characteristics, correlates with increases in SOL shoulder amplitude, A s, only under a subset of conditions (D2-fuelled L-mode density scans with outer strike point on the horizontal target). Λdiv fails to correlate with A s for cases of N2 seeding or during sweeping of the strike point across the horizontal target. The limited correlation of Λdiv and A s is also found for H-mode discharges. Thus, while it may be necessary for Λdiv to be above a threshold of ~1 for shoulder formation and/or growth, another mechanism is required. More significantly, we find that in contrast to parallel resistivity, outer divertor recycling, as quantified by the total outer divertor Balmer D α emission, I-D α , does scale with A s where Λdiv does and even where Λdiv does not. Divertor recycling could lead to SOL density shoulder formation through: (a) reducing the parallel to the field flow (loss) of ions out of the SOL to the divertor; and (b) changes in radial electric fields which lead to E  ×  B poloidal flows as well as potentially affecting SOL turbulence birth characteristics. Thus, changes in divertor recycling may be the sole process involved in bringing about SOL density shoulders or it may be that it acts in tandem with parallel resistivity.

  18. ELM Dynamics in TCV H-modes

    Science.gov (United States)

    Degeling, A. W.; Martin, Y. R.; Lister, J. B.; Llobet, X.; Bak, P. E.

    2003-06-01

    TCV (Tokamak à Configuration Variable, R = 0.88 m, a limited and diverted plasmas, with the primary aim of investigating the effects of plasma shape and current profile on tokamak physics and performance. L-mode to H-mode transitions are regularly obtained in TCV over a wide range of configurations. Under most conditions, the H-mode is ELM-free and terminates in a high density disruption. The conditions required for a transition to an ELMy H-mode were investigated in detail, and a reliable gateway in parameter space for the transition was identified. Once established, the ELMy H-mode is robust to changes in plasma current, elongation, divertor geometry and plasma density over ranges that are much wider than the size of the gateway in these parameters. There exists marked irregularity in the time interval between consecutive ELMs. Transient signatures in the time-series revealing the existence of an underlying chaotic dynamical system are repeatedly observed in a sizable group of discharges [1]. The properties of these signatures (called unstable periodic orbits, or UPOs) are found to vary systematically with parameters such as the plasma current, density and inner plasma — wall gap. A link has also been established between the dynamics of ELMs and sawteeth in TCV: under certain conditions a clear preference is observed in the phase between ELMs and sawtooth crashes, and the ratio of the ELM frequency (felm) to sawtooth frequency (fst) is found to prefer simple rational values (e.g. 1/1, 2/1 or 1/2). An attempt to control the ELM dynamics was made by applying a perturbation signal to the radial field coils used for vertical stabilisation. Phase synchronisation was found with the external perturbation, and felm was found to track limited scans in the driver frequency about the unperturbed value, albeit with intermittent losses in phase lock.

  19. ELM Dynamics in TCV H-modes

    International Nuclear Information System (INIS)

    Degeling, A.W.; Martin, Y.R.; Lister, J.B.; Llobet, X.; Bak, P.E.

    2003-01-01

    TCV (Tokamak a Configuration Variable, R = 0.88 m, a < 0.25 m, BT < 1.54 T) is a highly elongated tokamak, capable of producing limited and diverted plasmas, with the primary aim of investigating the effects of plasma shape and current profile on tokamak physics and performance. L-mode to H-mode transitions are regularly obtained in TCV over a wide range of configurations. Under most conditions, the H-mode is ELM-free and terminates in a high density disruption. The conditions required for a transition to an ELMy H-mode were investigated in detail, and a reliable gateway in parameter space for the transition was identified. Once established, the ELMy H-mode is robust to changes in plasma current, elongation, divertor geometry and plasma density over ranges that are much wider than the size of the gateway in these parameters. There exists marked irregularity in the time interval between consecutive ELMs. Transient signatures in the time-series revealing the existence of an underlying chaotic dynamical system are repeatedly observed in a sizable group of discharges [1]. The properties of these signatures (called unstable periodic orbits, or UPOs) are found to vary systematically with parameters such as the plasma current, density and inner plasma -- wall gap. A link has also been established between the dynamics of ELMs and sawteeth in TCV: under certain conditions a clear preference is observed in the phase between ELMs and sawtooth crashes, and the ratio of the ELM frequency (felm) to sawtooth frequency (fst) is found to prefer simple rational values (e.g. 1/1, 2/1 or 1/2). An attempt to control the ELM dynamics was made by applying a perturbation signal to the radial field coils used for vertical stabilisation. Phase synchronisation was found with the external perturbation, and felm was found to track limited scans in the driver frequency about the unperturbed value, albeit with intermittent losses in phase lock

  20. Long pulse operation of high performance plasmas in JT-60U

    International Nuclear Information System (INIS)

    Ide, Shunsuke

    2005-01-01

    Recent experimental progress in JT-60U advanced tokamak research is presented; sustainment of the normalized beta (β N ) - 3 in a normal magnetic shear plasma, the bootstrap current fraction (f BS ) - 45% in a weak shear plasma and ∼75% in a reversed magnetic shear plasma in a nearly full non-inductive current drive condition for longer than the current relaxation time. Achievement of high-density high-radiation fraction together with high-confinement in advanced plasmas was demonstrated. Achievement and foundings in long pulse operations after system modification are presented as well. A 65 s discharge of I p =0.7 MA was successfully obtained. As a result, high-β N of 2.3 was successfully sustained for a very long period of 22.3 s. In addition, a 30 s standard ELMy H-mode plasma of I p up to 1.4 MA has also been obtained. Effectiveness of divertor pumping to control particle recycling and the electron density under the wall retention was saturated was demonstrated. These achievement and issues in the development will be discussed. (author)

  1. Overview of long pulse H-mode operation on EAST

    Science.gov (United States)

    Gong, X.; Garofalo, A. M.; Wan, B.; Li, J.; Qian, J.; Li, E.; Liu, F.; Zhao, Y.; Wang, M.; Xu, H.; EAST Team

    2017-10-01

    The EAST research program aims to demonstrate steady-state long-pulse high-performance H-mode operations with ITER-like poloidal configuration and RF-dominated heating schemes. In the recent experimental campaign, a long pulse fully non-inductive H-mode discharge lasting over 100 seconds using the upper ITER-like tungsten divertor has been achieved in EAST. This scenario used only RF heating and current drive, but also benefitted from an integrated control of the wall conditioning, plasma configuration, divertor heat flux, particle exhaust, impurity management and superconducting coils safety. Maintaining effective coupling of multiple RF heating and current drive sources on EAST is a critical ingredient. This long pulse discharge had good energy confinement, H98,y2 1.1-1.2, and all of the plasma parameters reach a true steady-state. Power balance indicates that the confinement improvement is due partly to a significantly reduced core electron transport inside minor radius rho<0.4. This work was supported by the National Magnetic Confinement Fusion Program of China Contract No. 2015GB10200 and the US Department of Energy Contract No. DE-SC0010685.

  2. Development of high performance Schottky barrier diode and its application to plasma diagnostics

    International Nuclear Information System (INIS)

    Fujita, Junji; Kawahata, Kazuo; Okajima, Shigeki

    1993-10-01

    At the conclusion of the Supporting Collaboration Research on 'Development of High Performance Detectors in the Far Infrared Range' carried out from FY1990 to FY1992, the results of developing Schottky barrier diode and its application to plasma diagnostics are summarized. Some remarks as well as technical know-how for the correct use of diodes are also described. (author)

  3. Neutron Profiles and Fuel Ratio nT /nD Measurements in JET ELMy H-mode Plasmas with Tritium Puff

    Czech Academy of Sciences Publication Activity Database

    Bonheure, G.; Popovichev, S.; Bertalot, L.; Murari, A.; Conroy, S.; Mlynář, Jan; Voitsekhovitch, I.

    2006-01-01

    Roč. 46, č. 7 (2006), s. 725-740 ISSN 0029-5515 Institutional research plan: CEZ:AV0Z20430508 Keywords : fusion * JET * plasma profile * tomography * neutron diagnostics * fuel * tritium transport Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.839, year: 2006

  4. Physico-chemical characteristics of high performance polymer modified by low and atmospheric pressure plasma

    International Nuclear Information System (INIS)

    Bhatnagar, Nitu; Sangeeta, Jha; Bhowmik, Shantanu; Gupta, Govind; Moon, J.B.; Kim, C.G.

    2012-01-01

    In this work, the effect of low pressure plasma and atmospheric p ressure plasma treatment on surface properties and adhesion characteristics of high performance polymer, Polyether Ether Ketone (PEEK) are investigated in terms of Fourier Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and Atomic Force Microscopy (AFM). The experimental results show that the PEEK surface treated by atmospheric pressure plasma lead to an increase in the polar component of the surface energy, resulting in improving the adhesion characteristics of the PEEK/Epoxy adhesive system. Also, the roughness of the treated surfaces is largely increased as confirmed by AFM observation. These results can be explained by the fact that the atmospheric pressure plasma treatment of PEEK surface yields several oxygen functionalities on hydrophobic surface, which play an important role in increasing the surface polarity, wettability, and the adhesion characteristics of the PEEK/Epoxy adhesive system. (authors)

  5. D-T plasma of self-sustained burning under high performance

    International Nuclear Information System (INIS)

    Gong Xueyu

    2003-01-01

    By adopting a Bohm-type thermal diffusion coefficient related to the energy confinement enhancement factor H within the conventional magnetic shear regime, and a mixed Bohm-gyro-Bohm thermal diffusion coefficient related to the shear within the negative central magnetic shear regime, considering the effect of the α particle anomalous diffusion and the dynamic feedback heating, and starting from energy transport of electrons and ions, we have studied the high performance self-sustaining burning deuterium-tritium plasma under a given plasma density profile for the two different kinds of magnetic shear regimes. Some conclusions are obtained: under the conventional shear, only when H≥3, the D-T burning can produce a large power output, and when H is larger than a certain value (H≅4), D-T plasma self-sustained burning can be maintained without the dynamic feedback heating; under the negative central shear, the plasmas have a higher plasma performance and a larger power output than that under conventional shear, and D-T plasma self-sustained burning can be maintained without the dynamic feedback heating power, the suitable alpha particle diffusion is advantage ous to D-T plasma burning under the conventional shear, and D-T self-sustained burning cannot be maintained under a large α particle anomalous diffusion for the negative central shear. The dynamic feedback heating power is important for sustaining D-T plasma burning under the conventional shear

  6. Scaling of the H-mode power threshold for ITER

    International Nuclear Information System (INIS)

    1998-01-01

    Analysis of the latest ITER H-mode threshold database is presented. The power necessary for the transition to H-mode is estimated for ITER, with or without the inclusion of radiation losses from the bulk plasma, in terms of the main engineering variables. The main geometrical variables (aspect ratio ε, elongation κ and average triangularity δ) are also included in the analysis. The H-mode transition is also considered from the point of view of the local edge variables, and the electron temperature at 90% of the poloidal flux is expressed in terms of both local and global variables. (author)

  7. High Performance Liquid Chromatographic Method for Determination of Dipyridamole in Human Plasma

    Directory of Open Access Journals (Sweden)

    DAVOOD BEIGI BAND ARAB ADI

    1999-08-01

    Full Text Available A simple, rapid and specific high-performance liquid chromatographic procedure is reported for"nquantitative determination of dipyridamole in human -plasma. The assay uses a reversed-phase"nhigh-performance liquid chromatographic (HPLC and UV detection at 280nm and has a limit"nof detection of approximately 5ng/mL. The mobile phase consists of MeOH-H20 (60:40"nadjusted to pH 3.3. Dipyridamole was extracted from plasma by back-extraction procedure, with"npropranolol as the internal standard. The reproducibility of the method is satisfactory

  8. Coupling nanoliter high-performance liquid chromatography to inductively coupled plasma mass spectrometry for arsenic speciation.

    Science.gov (United States)

    Cheng, Heyong; Shen, Lihuan; Liu, Jinhua; Xu, Zigang; Wang, Yuanchao

    2018-04-01

    Nanoliter high-performance liquid chromatography shows low consumption of solvents and samples, offering one of the best choices for arsenic speciation in precious samples in combination with inuctively coupled plasma mass spectrometry. A systematic investigation on coupling nanoliter high-performance liquid chromatography to inductively coupled plasma mass spectrometry from instrument design to injected sample volume and mobile phase was performed in this study. Nanoflow mobile phase was delivered by flow splitting using a conventional high-pressure pump with reuse of mobile phase waste. Dead volume was minimized to 60 nL for the sheathless interface based on the previously developed nanonebulizer. Capillary columns for nanoliter high-performance liquid chromatography were found to be sensitive to sample loading volume. An apparent difference was also found between the mobile phases for nanoliter and conventional high-performance liquid chromatography. Baseline separation of arsenite, arsenate, monomethylarsenic, and dimethylarsenic was achieved within 11 min on a 15 cm C 18 capillary column and within 12 min on a 25 cm strong anion exchange column. Detection limits of 0.9-1.8 μg/L were obtained with precisions variable in the range of 1.6-4.2%. A good agreement between determined and certified values of a certified reference material of human urine (GBW 09115) validated its accuracy along with good recoveries (87-102%). © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography.

    Science.gov (United States)

    Ding, T L; Benet, L Z

    1979-07-21

    Using 1-ml plasma samples, levels of 6-mercaptopurine (6MP) as low as 5 ng/ml and azathioprine (AZA) as low as 40 ng/ml can be detected using a high-performance liquid chromatography reversed-phase column procedure following extraction. Both compounds were stable in frozen plasma for seven weeks. AZA stability in blood was temperature dependent; the half-lives of AZA breakdown to 6MP at 37 degrees were 28 and 46 min in blood drawn from two rhesus monkeys. Plasma levels of 6MP were measured in a rhesus monkey following 6MP (1.47 mg/kg) and AZA (3 mg/kg) intravenous administration. 6MP levels were also measured in three renal transplant patients on daily 50- and 100-mg AZA doses. Peak levels (45-75 ng/ml) were reached within an hour and 6MP levels were detected for up to 7 h.

  10. H-Mode Turbulence, Power Threshold, ELM, and Pedestal Studies in NSTX

    International Nuclear Information System (INIS)

    Maingi, R.; Bush, C.E.; Fredrickson, E.D.; Gates, D.A.; Kaye, S.M.; LeBlanc, B.P.; Menard, J.E.; Meyer, H.; Mueller, D.; Nishino, N.; Roquemore, A.L.; Sabbagh, S.A.; Tritz, K.; Zweben, S.J.; Bell, M.G.; Bell, R.E.; Biewer, T.; Boedo, J.A.; Johnson, D.W.; Kaita, R.; Kugel, H.W.; Maqueda, R.J.; Munsat, T.; Raman, R.; Soukhanovskii, V.A.; Stevenson, T.; Stutman, D.

    2004-01-01

    High-confinement mode (H-mode) operation plays a crucial role in NSTX [National Spherical Torus Experiment] research, allowing higher beta limits due to reduced plasma pressure peaking, and long-pulse operation due to high bootstrap current fraction. Here, new results are presented in the areas of edge localized modes (ELMs), H-mode pedestal physics, L-H turbulence, and power threshold studies. ELMs of several other types (as observed in conventional aspect ratio tokamaks) are often observed: (1) large, Type I ELMs, (2) ''medium'' Type II/III ELMs, and (3) giant ELMs which can reduce stored energy by up to 30% in certain conditions. In addition, many high-performance discharges in NSTX have tiny ELMs (newly termed Type V), which have some differences as compared with ELM types in the published literature. The H-mode pedestal typically contains between 25-33% of the total stored energy, and the NSTX pedestal energy agrees reasonably well with a recent international multi-machine scaling. We find that the L-H transition occurs on a ∼100 (micro)sec timescale as viewed by a gas puff imaging diagnostic, and that intermittent quiescent periods precede the final transition. A power threshold identity experiment between NSTX and MAST shows comparable loss power at the L-H transition in balanced double-null discharges. Both machines require more power for the L-H transition as the balance is shifted toward lower single null. High field side gas fueling enables more reliable H-mode access, but does not always lead to a lower power threshold e.g., with a reduction of the duration of early heating. Finally the edge plasma parameters just before the L-H transition were compared with theories of the transition. It was found that while some theories can separate well-developed L- and H-mode data, they have little predictive value

  11. Generalized MHD for numerical stability analysis of high-performance plasmas in tokamaks

    International Nuclear Information System (INIS)

    Mikhailovskii, A.B.

    1998-01-01

    A set of generalized magnetohydrodynamic (MHD) equations is formulated to accommodate the effects associated with high ion and electron temperatures in high-performance plasmas in tokamaks. The effects of neoclassical bootstrap current, neoclassical ion viscosity, the ion finite Larmor radius effect and electron and ion drift effects are taken into account in two-fluid MHD equations together with gyroviscosity, parallel viscosity, electron parallel inertia and collisionless ion heat flux. The ion velocity is identified as the plasma velocity, while the electron velocity is expressed in terms of the plasma velocity and electric current. Ion and electron momentum equations are combined to give the plasma momentum equation. The perpendicular (with respect to the equilibrium magnetic field) ion momentum equation is used as perpendicular Ohm's law and the parallel electron momentum equation - as parallel Ohm's law. Perpendicular Ohm's law allows for the Hall and ion drift effects. Parallel Ohm's law includes the electron drift effect, collisionless skin effect and bootstrap current. In addition, both perpendicular and parallel Ohm's laws contain the resistivity. Due to the quasineutrality condition, the ions and electrons are characterized by the same number density which is described by the ion continuity equation. On the other hand, the ion and electron temperatures are allowed to be different. The ion temperature is described by the ion energy equation allowing for the oblique heat flux, in addition to the perpendicular ion heat flux. The electron temperature is determined by the condition of high parallel electron heat conductivity. The ion and electron parallel viscosities are represented in a form valid for all the collisionality regimes (Pfirsch-Schluter, plateau, and banana). An optimized form of the generalized MHD equations is then represented in terms of the toroidal coordinate system used in the JET equilibrium and stability codes. The derived equations

  12. High-performance modeling of plasma-based acceleration and laser-plasma interactions

    Science.gov (United States)

    Vay, Jean-Luc; Blaclard, Guillaume; Godfrey, Brendan; Kirchen, Manuel; Lee, Patrick; Lehe, Remi; Lobet, Mathieu; Vincenti, Henri

    2016-10-01

    Large-scale numerical simulations are essential to the design of plasma-based accelerators and laser-plasma interations for ultra-high intensity (UHI) physics. The electromagnetic Particle-In-Cell (PIC) approach is the method of choice for self-consistent simulations, as it is based on first principles, and captures all kinetic effects, and also scale favorably to many cores on supercomputers. The standard PIC algorithm relies on second-order finite-difference discretization of the Maxwell and Newton-Lorentz equations. We present here novel formulations, based on very high-order pseudo-spectral Maxwell solvers, which enable near-total elimination of the numerical Cherenkov instability and increased accuracy over the standard PIC method for standard laboratory frame and Lorentz boosted frame simulations. We also present the latest implementations in the PIC modules Warp-PICSAR and FBPIC on the Intel Xeon Phi and GPU architectures. Examples of applications will be given on the simulation of laser-plasma accelerators and high-harmonic generation with plasma mirrors. Work supported by US-DOE Contracts DE-AC02-05CH11231 and by the European Commission through the Marie Slowdoska-Curie fellowship PICSSAR Grant Number 624543. Used resources of NERSC.

  13. [Determination of acyclovir in mouse plasma and tissues by reversed-phase high performance liquid chromatography].

    Science.gov (United States)

    Xu, Y; Zhou, S W; Tang, J L; Huang, L Q

    2001-11-01

    The aim of this study was to establish an high performance liquid chromatographic method for determining acyclovir (ACV) concentration in mouse plasma and tissues. A solution of 0.25 mL 60 g/L perchloric acid and 0.25 mL acetonitrile was added into 0.2 mL plasma or 0.2 g tissues to precipitate proteins. Following centrifugation, the supernatant obtained was injected into a reversed-phase column. Operating conditions were Hypersil ODS column(250 mm x 4.6 mm i.d., 5 microns), methanol-water-acetic acid(1:99:0.5, volume ratio) solution as mobile phase at a flow rate of 1.5 mL/min, UV detection at 252 nm. The detection limit of ACV concentration in plasma was 20 micrograms/L and that in tissues was 50 ng/g. The standard curves for ACV were linear in plasma and homogenate of tissues (r > 0.99). The precision of the method was good and the recoveries of ACV were higher than 97.5%. So this method is rapid, accurate and convenient for determination of ACV concentrations in plasma and tissues.

  14. Magnetic-Flux Pumping in High-Performance, Stationary Plasmas with Tearing Modes

    International Nuclear Information System (INIS)

    Petty, C. C.; Austin, M. E.; Holcomb, C. T.; Jayakumar, R. J.; La Haye, R. J.; Luce, T. C.; Makowski, M. A.; Politzer, P. A.; Wade, M. R.

    2009-01-01

    Analysis of the change in the magnetic field pitch angles during edge localized mode events in high performance, stationary plasmas on the DIII-D tokamak shows rapid (<1 ms) broadening of the current density profile, but only when a m/n=3/2 tearing mode is present. This observation of poloidal magnetic-flux pumping explains an important feature of this scenario, which is the anomalous broadening of the current density profile that beneficially maintains the safety factor above unity and forestalls the sawtooth instability

  15. Stereospecific high-performance liquid chromatographic assay of sotalol in plasma.

    Science.gov (United States)

    Carr, R A; Foster, R T; Bhanji, N H

    1991-09-01

    A convenient high-performance liquid chromatographic (HPLC) assay was developed for determination of sotalol (STL) enantiomers in plasma. Following addition of the internal standard (IS; racemic atenolol), enantiomers of STL and IS were extracted using ethyl acetate. After evaporation of the organic layer, samples were derivatized with a solution of S-(+)-1-(1-naphthyl)ethyl isocyanate (NEIC). The resulting diastereomers were chromatographed with normal-phase HPLC with chloroform:hexane:methanol [65:33:2 (v/v)] as the mobile phase at a flow rate of 2 ml/min. The fluorescence detection wavelength was set at 220 nm for excitation with no emission filter. The suitability of the assay for pharmacokinetic studies was determined by measuring STL enantiomers in the plasma of a healthy subject after administration of a single 160-mg oral, racemic dose of STL.

  16. High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

    Science.gov (United States)

    Zaffaroni, M; Mucignat, C; Pecere, T; Zagotto, G; Frapolli, R; D'Incalci, M; Zucchetti, M

    2003-10-25

    An isocratic high-performance liquid chromatography (HPLC) method was developed and validated to determine Aloe Emodin (AE) in mouse plasma. The analysis required 0.3 ml of plasma and involves extraction with dichloromethane. The HPLC separation was carried out on Symmetry Shield RP18, a mobile phase of methanol-water-acetic acid (65:35:0.2) and fluorescence detection at lambda(ex)=410 nm and lambda(em)=510 nm. The retention time of AE was 11.7 min. The assay was linear from 10 to 1,000 ng/ml (r2 > or = 0.999), showed intra- and inter-day precision within 7.8 and 4.7%, and accuracy of 87.3-105.7%. Detection limit (LOD) and quantification limit (LOQ) were 4.5 and 5 ng/ml, respectively. The method was applied to determine for the first time the pharmacokinetic of AE in mice.

  17. Comparison of hybrid and baseline ELMy H-mode confinement in JET with the carbon wall

    NARCIS (Netherlands)

    Beurskens, M. N. A.; Frassinetti, L.; Challis, C.; Osborne, T.; Snyder, P. B.; Alper, B.; Angioni, C.; Bourdelle, C.; Buratti, P.; Crisanti, F.; Giovannozzi, E.; Giroud, C.; Groebner, R.; Hobirk, J.; Jenkins, I.; Joffrin, E.; Leyland, M. J.; Lomas, P.; Mantica, P.; McDonald, D.; Nunes, I.; Rimini, F.; Saarelma, S.; Voitsekhovitch, I.; P. de Vries,; Zarzoso, D.

    2013-01-01

    The confinement in JET baseline type I ELMy H-mode plasmas is compared to that in so-called hybrid H-modes in a database study of 112 plasmas in JET with the carbon fibre composite (CFC) wall. The baseline plasmas typically have beta(Nu) similar to 1.5-2, H-98 similar to 1, whereas the hybrid

  18. Simple Quantification of Pentosidine in Human Urine and Plasma by High-Performance Liquid Chromatography

    Directory of Open Access Journals (Sweden)

    Ji Sang Lee

    2017-01-01

    Full Text Available Pentosidine is an advanced glycation end-product (AGE and fluorescent cross-link compound. A simple high-performance liquid chromatographic (HPLC method was developed for the detection and quantification of pentosidine in human urine and plasma. The mobile phase used a gradient system to improve separation of pentosidine from endogenous peaks, and chromatograms were monitored by fluorescent detector set at excitation and emission wavelengths of 328 and 378 nm, respectively. The retention time for pentosidine was 24.3 min and the lower limits of quantification (LLOQ in human urine and plasma were 1 nM. The intraday assay precisions (coefficients of variation were generally low and found to be in the range of 5.19–7.49% and 4.96–8.78% for human urine and plasma, respectively. The corresponding values of the interday assay precisions were 9.45% and 4.27%. Accuracies (relative errors ranged from 87.9% to 115%. Pentosidine was stable in a range of pH solutions, human urine, and plasma. In summary, this HPLC method can be applied in future preclinical and clinical evaluation of pentosidine in the diabetic patients.

  19. High-performance liquid chromatographic quantification of rifampicin in human plasma: method for Therapecutic drug monitoring

    International Nuclear Information System (INIS)

    Sameh, T.; Hanene, E.; Jebali, N.

    2013-01-01

    A high performance liquid chromatography (HPLC) method has been developed that allows quantification of Rifampicin in human plasma. The method is based on the precipitation of proteins in human plasma with methanol. Optimal assay conditions were found with a C18 column and a simple mobile phase consisting of 0.05 M dipotassic hydrogen phosphate buffer and acetonitrile (53/47, V/V) with 0.086 % diethylamin, pH = 4.46. The flow-rate was 0.6 ml /mm and the drug was monitored at 340 nm. Results from the HPLC analyses showed that the assay method is linear in the concentration range of 1-40 micro g/ml, (r2 >0.99). The limit of quantification and limit of detection of Rifampicin were 0.632 micro g/ml and 0.208 micro g/ml, respectively. Intraday and interday coefficient of variation and bias were below 10% for all samples, suggesting good precision and accuracy of the method. Recoveries were greater than 90% in a plasma sample volume of 100 micro l. The method is being successfully applied to therapeutic drug monitoring of Rifapicin in plasma samples of tuberculosis and staphylococcal infections patients. (author)

  20. Determination of modafinil in plasma and urine by reversed phase high-performance liquid-chromatography.

    Science.gov (United States)

    Schwertner, Harvey A; Kong, Suk Bin

    2005-03-09

    Modafinil (Provigil) is a new wake-promoting drug that is being used for the management of excessive sleepiness in patients with narcolepsy. It has pharmacological properties similar to that of amphetamine, but without some of the side effects associated with amphetamine-like stimulants. Since modafinil has the potential to be abused, accurate drug-screening methods are needed for its analysis. In this study, we developed a high-performance liquid-chromatographic procedure (HPLC) for the quantitative analysis of modafinil in plasma and urine. (Phenylthio)acetic acid was used as an internal standard for the analysis of both plasma and urine. Modafinil was extracted from urine and plasma with ethyl acetate and ethyl acetate-acetic acid (100:1, v/v), respectively, and analyzed on a C18 reverse phase column with methanol-water-acetic acid (500:500:1, v/v) as the mobile phase. Recoveries from urine and plasma were 80.0 and 98.9%, respectively and the limit of quantitation was 0.1 microg/mL at 233 nm. Forty-eight 2-h post-dose urine samples from sham controls and from individuals taking 200 or 400 mg of modafinil were analyzed without knowledge of drug administration. All 16-placebo urine samples and all 32 2-h post-dose urine samples were correctly classified. The analytical procedure is accurate and reproducible and can be used for therapeutic drug monitoring, pharmacokinetic studies, and drug abuse screening.

  1. Collisional drift waves in the H-mode edge

    International Nuclear Information System (INIS)

    Sen, S.

    1994-01-01

    The stability of the collisional drift wave in a sheared slab geometry is found to be severely restricted at the H-mode edge plasma due to the very steep density gradient. However, a radially varying transverse velocity field is found to play the key role in stability. Velocity profiles usually found in the H-mode plasma stabilize drift waves. On the other hand, velocity profiles corresponding to the L-mode render collisional drift waves unstable even though the magnetic shear continues to play its stabilizing role. (author). 24 refs

  2. Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography.

    Science.gov (United States)

    Shrestha, Rojeet; Hui, Shu-Ping; Imai, Hiromitsu; Hashimoto, Satoru; Uemura, Naoto; Takeda, Seiji; Fuda, Hirotoshi; Suzuki, Akira; Yamaguchi, Satoshi; Hirano, Ken-Ichi; Chiba, Hitoshi

    2015-09-01

    Capric acid (FA10:0, decanoic acid) is a medium-chain fatty acid abundant in tropical oils such as coconut oil, whereas small amounts are present in milk of goat, cow, and human. Orally ingested FA10:0 is transported to the liver and quickly burnt within it. Only few reports are available for FA10:0 concentrations in human plasma. Fasting (n = 5, male/female = 3/2, age 31 ± 9.3 years old) and non-fasting (n = 106, male/female = 44/62, age 21.9 ± 3.2 years old) blood samples were collected from apparently healthy Japanese volunteers. The total FA10:0 in the plasma were measured by high-performance liquid chromatography after derivatization with 2-nitrophenylhydrazine followed by UV detection. Inter and intra-assay coefficient of variation of FA10:0 assay at three different concentrations ranged in 1.7-3.9 and 1.3-5.4%, respectively, with an analytical recovery of 95.2-104.0%. FA10:0 concentration was below detection limit (0.1 µmol/L) in each fasting human plasma. FA10:0 was not detected in 50 (47.2%) of 106 non-fasting blood samples, while 29 (27.4%) plasma samples contained FA10:0 less than or equal to 0.5 µmol/L (0.4 ± 0.1), and 27 (25.5%) contained it at more than 0.5 µmol/L (0.9 ± 0.3). A half of the non-fasting plasma samples contained detectable FA10:0. This simple, precise, and accurate high-performance liquid chromatography method might be useful for monitoring plasma FA10:0 during medium-chain triglycerides therapy. © The Author(s) 2015.

  3. Ohmic H-mode studies in TUMAN-3

    International Nuclear Information System (INIS)

    Lebedev, S.V.; Andrejko, M.V.; Askinazi, L.G.; Golant, V.E.; Kornev, V.A.; Levin, L.S.; Tukachinsky, A.S.; Tendler, M.

    1994-01-01

    The spontaneous transition from Ohmically heated limiter discharges into the regime with improved confinement termed as ''Ohmic H-mode'' has been investigated in ''TUMAN-3''. The typical signatures of H-mode in tokamaks with powerful auxiliary heating have been observed: sharp drop of D α radiation with simultaneous increase in the electron density and stored energy, suppression of the density fluctuations and establishing the steep gradient near the periphery. The crucial role of the radial electric field in the L-H transition was found in the experiments with boundary biasing. The possibility of initiating the H-mode using single pellet injection was demonstrated. In Ohmic H-mode strong dependencies of τ E on plasma current and on input power and weak dependence on density were found. Thermal energy confinement time enhanced by a factor of 10 compared to predictions of Neo-Alcator scaling. Longest energy confinement time (30 ms) was obtained in the small tokamak TUMAN-3. Absolute values of the energy confinement time are in agreement with scaling proposed for description of the ELM-free H-modes in devices with powerful auxiliary heating (''DIII-D/JET H-mode'' scaling). (author)

  4. Determination of Flurbiprofen in Human Plasma by High-Performance Liquid Chromatography.

    Science.gov (United States)

    Yilmaz, Bilal; Erdem, Ali Fuat

    2015-10-01

    A simple high-performance liquid chromatography method has been developed for determination of flurbiprofen in human plasma. The method was validated on an Ace C18 column using UV detection. The mobile phase was acetonitrile-0.05 M potassium dihydrogen phosphate solution (60:40, v/v) adjusted to pH 3.5 with phosphoric acid. The calibration curve was linear between the concentration range of 0.10-5.0 μg/mL. Intra- and inter-day precision values for flurbiprofen in plasma were flurbiprofen from human plasma were between 93.0 and 98.9%. The limits of detection and quantification of flurbiprofen were 0.03 and 0.10 μg/mL, respectively. In addition, this assay was applied to determine the pharmacokinetic parameters of flurbiprofen in six healthy Turkish volunteers who had been given 100 mg flurbiprofen. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Applications of plasma spectrometry and high performance liquid chromatography in environmental and food science

    International Nuclear Information System (INIS)

    Iordache, Andreea-Maria; Biraruti, Elisabeta-Irina; Ionete, Roxana-Elena

    2008-01-01

    Full text: Plasma spectrometry has many applications in food science in analysis of a wide range of samples in the food chain. Food science in the broadest sense can be extended to include soil chemistry, plant uptake and, at the other end of the food chain, studies into the metabolic fate of particular elements or elemental species when the foods are consumed by humans or animals. Inductively Coupled Plasma Mass Spectrometry allows multi-element measurements of most elements in the periodic table. A very sensitive analytical technique for trace analysis of samples can be performed by inductively plasma mass spectrometer with quadrupolar detector using ultrasonic nebulization. High Performance Liquid Chromatography (HPLC) is an analytical technique for the separation and determination of organic and inorganic solutes in any samples especially biological, pharmaceutical, food, environmental. The present paper emphasizes that the future tendencies HPLC-ICP-MS is often the preferred analytical technique for these applications due to the simplicity of the coupling between the HPLC and ICP-MS Varian 820 using ultrasonic nebulization, potential for on-line separations with high species specificity and the capability for optimum limits of detection without the necessity of using complex hydride generation mechanisms. (authors)

  6. On global H-mode scaling laws for JET

    International Nuclear Information System (INIS)

    Kardaun, O.; Lackner, K.; Thomsen, K.; Christiansen, J.; Cordey, J.; Gottardi, N.; Keilhacker, M.; Smeulders, P.

    1989-01-01

    Investigation of the scaling of the energy confinement time τ E with various plasma parameters has since long been an interesting, albeit not uncontroversial topic in plasma physics. Various global scaling laws have been derived for ohmic as well as (NBI and/or RF heated) L-mode discharges. Due to the scarce availability of computerised, extensive and validated H-mode datasets, systematic statistical analysis of H-mode scaling behaviour has hitherto been limited. A common approach is to fit the available H-mode data by an L-mode scaling law (e.g., Kaye-Goldston, Rebut-Lallia) with one or two adjustable constant terms. In this contribution we will consider the alternative approach of fitting all free parameters of various simple scaling models to two recently compiled datasets consisting of about 140 ELM-free and 40 ELMy H-mode discharges, measured at JET in the period 1986-1988. From this period, approximately all known H-mode shots have been included that satisfy the following criteria: D-injected D + discharges with no RF heating, a sufficiently long (≥300 ms) and regular P NBI flat-top, and validated main diagnostics. (author) 13 refs., 1 tab

  7. Inductively coupled plasma emission spectrometric detection of simulated high performance liquid chromatographic peaks

    International Nuclear Information System (INIS)

    Fraley, D.M.; Yates, D.; Manahan, S.E.

    1979-01-01

    Because of its multielement capability, element-specificity, and low detection limits, inductively coupled plasma optical emission spectrometry (ICP) is a very promising technique for the detection of specific elemental species separated by high performance liquid chromatography (HPLC). This paper evaluated ICP as a detector for HPLC peaks containing specific elements. Detection limits for a number of elements have been evaluated in terms of the minimum detectable concentration of the element at the chromatographic peak maximum. The elements studies were Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, P, Pb, Sb, Se, Sr, Ti, V, and Zn. In addition, ICP was compared with atomic absorption spectrometry for the detection of HPLC peaks composed of EDTA and NTA chelates of copper. Furthermore, ICP was compared to uv solution absorption for the detection of copper chelates. 6 figures, 4 tables

  8. A simple, high performance Thomson scattering diagnostic for high temperature plasma research

    International Nuclear Information System (INIS)

    Hartog, D.J.D.; Cekic, M.

    1994-02-01

    This Thomson scattering diagnostic is used to measure the electron temperature and density of the plasma in the MST reversed-field pinch, a magnetic confinement fusion research device. This diagnostic system is unique for its type in that it combines high performance with simple design and low cost components. In the design of this instrument, careful attention was given to the suppression of stray laser line light with simple and effective beam dumps, viewing dumps, aperatures, and a holographic edge filter. This allows the use of a single grating monochromator for dispersion of the Thomson scattered spectrum onto the microchannel plate detector. Alignment and calibration procedures for the laser beam delivery system, the scattered light collection system, and the spectrometer and detector are described. A sample Thomson scattered spectrum illustrates typical data

  9. Phenomenological model for H-mode

    International Nuclear Information System (INIS)

    Ohyabu, N.

    1985-08-01

    A phenomenological model has been developed to clarify the role of the boundary configuration in the heat transport of the H-mode regime. We assume that the dominant mechanism of heat loss at the edge of the plasma is convection and that the diffusion coefficient (D/sub edge/) at the edge of the plasma increases rapidly with plasma pressure, but drops to a low value when the temperature exceeds a certain threshold value. When particle refueling takes place without time delay, as in the case of a limiter discharge, the unfavorable temperature dependence of the D/sub edge/ prohibits even a modest rise of the edge temperature. In a divertor discharge, the particles lost from the closed surface are kept away from the edge region for a time comparable to or longer than the energy transport time in the edge region. Thus, rapid increase in the heat flux allows an excursion of the edge temperature to a higher value thereby reaching the threshold value of the H-transition

  10. LH transition theories and theory of H-mode

    International Nuclear Information System (INIS)

    Ward, D.J.

    1996-01-01

    Recent developments in H-mode theory are discussed with earlier work described to put new theories in context. Much of the recent work concerns the development of the radial electric field near the plasma edge and its impact on transport driven by fluctuations, and is the main topic discussed. (author)

  11. [Determination of oxaprozin in human plasma with high performance liquid chromatography (HPLC) and its application].

    Science.gov (United States)

    Mao, Mian; Wang, Ling; Jiang, Xuehua; Yang, Lin

    2013-06-01

    The present research was aimed to develop a high performance liquid chromatography (HPLC) method to determine oxaprozin in plasma and to evaluate the bioavailability of two oxaprozin enteric coated tablets. A C18 column was used to separate the plasma after protein precipitation and the mobile phase was methanol-12. 5mmol/L ammonium acetate buffer solution (pH=3.0)(71:29). The calibration curve was linear in the concentration range of 0. 50-70. 56 microg . mL-1, and the intra and inter-day RSDs were less than 12. 33% and 10. 42% respectively. A single dose of 0. 4 g reference preparation or test preparation of oxaprozin enteric coated tablets was administered to 20 healthy volunteers according to a randomized crossover study. AUC0-->264h were (4 917. 44 +/- 629. 57) microg . h . mL-1 and (4 604. 30+/-737. 83) microg . h . mL-1, respectively; Cmax were (52. 34+/-7. 68) microg . mL-1 and (48. 66+/-4. 87) microg . mL-1, respectively; Tmax were (18. 70+/-2.27) h and (19. 30+/-1. 63) h, respectively; The relative bioavailability of test preparation was 94.0% +/- 13. 7%. The method is simple, rapid and selective for oxaprozin determination. There is no significant difference in the main pharmacokinetic parameters between the test formulation and reference formulation and the two formulations are in bioequivalence.

  12. [Determination of sulpride in human plasma by high performance liquid chromatography].

    Science.gov (United States)

    Yu, X; Luo, Z; Tang, J; Yu, P

    1997-11-01

    This paper describes a reliable method for the pharmacokinetic study of Sulpride in human plasma by reversed-phase high performance liquid chromatography. To compensate the loss of Sulpride during the extraction procedure we used an internal standard very similar in chemical structure and UV absorbance to those of Sulpride. The mobile phase was methanol-water-acetic acid (60:30:1) with a flow rate of 1.2 mL/min. A UV detector was used at 290 nm. The linear range was 5-100 mg/L and the detectable limit was 1.0 mg/L. The recovery and RSD were 97.95%-99.96% and 2.6%-5.1% respectively. The results showed that this method is a sensitive and accurate one which makes the pharmacokinetic study of Sulpride possible. If the concentration was too low to be detected by UV monitor, a fluorescence detector could be used with the excitation wavelength at 299 nm and emission at 342 nm. We analyzed the plasma samples from 30 day-treated psychotic patients and got the satisfactory results.

  13. Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography.

    Science.gov (United States)

    Yu, Panfeng; Wang, Qi; Ma, Hongwei; Wu, Ji; Shen, Shun

    2014-05-15

    This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites anchored onto multi-walled carbon nanotubes (MWCNTs@Fe3O4). In order to enhance the water solubility of MWCNTs@Fe3O4 that ensured sufficient contact between nanosorbents and analytes in the sampling procedure, the obtained nanomaterials were further noncovalently functionalized using a phospholipids-polyethylene glycol (DSPE-PEG). The PEGylated MWCNTs@Fe3O4 nanomaterials had an extremely large surface area and exhibit a strong interaction capability for puerarin with π-π stacking interactions. The captured puerarin/nanosorbents were easily isolated from the plasma by placing a magnet, and desorbed by acetonitrile. The experimental variables affecting the extraction efficiency were investigated. The calibration curve of puerarin was linear from 0.01 to 20 μg/ml, and the limit of detection was 0.005 μg/ml. The precisions ranged from 2.7% to 3.5% for within-day measurement, and for between-day variation was in the range of 3.1-5.9%. The method recoveries were acquired from 95.2% to 98.0%. Moreover, the analytical performance obtained by PEGylated magnetic MWCNTs was also compared with that of magnetic MWCNTs. All results showed that our proposed method was an excellent alternative for the analysis of puerarin in rat plasma. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Transition to H-mode by energetic electrons

    International Nuclear Information System (INIS)

    Itoh, Kimitaka; Itoh, Sanae.

    1992-07-01

    Effect of the electron loss due to the toroidal ripple on an H-mode transition is studied. When energetic electrons exist in tokamaks, e.g., in the case of the current drive by lower hybrid (LH) waves, the edge electric field can show the bifurcation to the more positive value. In this state, both the electron loss and ion loss (such as loss cone loss) are reduced. The criterion for the transition is derived. Comparison with H-mode in JT-60 LH plasma shows a qualitative agreement. (author)

  15. Change of transport at L- and H-mode transition

    International Nuclear Information System (INIS)

    Itoh, Sanae-I; Itoh, Kimitaka.

    1990-01-01

    A new refined model of the L-mode and H-mode transition in tokamaks is presented based on the bifurcation of the radial electric field, E r , near edge. The radial gradient of E r is newly introduced to explain the sudden change of fluctuations as well as plasma fluxes at the onset of transition. This model predicts that the L-to H-mode transition is associated with the decrease of dE r /dr causing reduction of particle and energy fluxes at critical gradient. (author)

  16. Improved H-mode access in connected DND in MAST

    International Nuclear Information System (INIS)

    Meyer, H; Carolan, P G; Conway, N J; Counsell, G F; Cunningham, G; Field, A R; Kirk, A; McClements, K G; Price, M; Taylor, D

    2005-01-01

    In the Mega-Amp Spherical Tokamak, MAST, the formation of the edge transport barrier leading to the high-confinement (H-mode) regime is greatly facilitated by operating in a double null diverted (DND) configuration where both X-points are practically on the same flux surface. Ohmic H-modes are presently only obtained in these connected double null diverted (CDND) configurations. The ease of H-mode access is lost if the two flux surfaces passing through the X-points are radially separated by more than one ion Larmor radius (ρ i ∼ 6 mm) at the low-field-side mid-plane. The change of the magnetic configuration from disconnected to CDND is accompanied by a change in the radial electric field of about ΔE ψ ∼ -1 kV m -1 and a reduction of the electron temperature decay length in the high-field-side scrape-off-layer. Other parameters at the plasma edge, in particular those affecting the H-mode access criteria of common L/H transition theories, are not affected by the slight changes to the magnetic configuration. It is believed that the observed change in E ψ , which may result from differences in ion orbit losses, leads to a higher initial E x B flow shear in CDND configurations which could lead to the easier H-mode access

  17. Arsenic speciation in soil using high performance liquid chromatography/inductively coupled plasma/mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Bass, D.A.; Yaeger, J.S.; Parish, K.J.; Crain, J.S.; Kiely, J.T.; Gowdy, M.J. [Argonne National Lab., IL (United States); Mohrman, G.B.; Besmer, M.G. [Rocky Mountain Arsenal, Commerce City, CO (United States)

    1996-08-01

    A method has been developed to identify and quantify As(III), As(V), and organoarsenic compounds in soil samples from the Rocky Mountain Arsenal (RMA) by high performance liquid chromatography/inductively coupled plasma/mass spectrometry (HPLC/ICP/MS). The soils were extracted using tetrabutylammonium hydroxide (TBAH) and sonication. The percentages of As(III), As(V), and organoarsenic species extracted from soil samples were 30, 50, and 100 respectively. The arsenic species were not altered during the extraction process. They were separated by reversed-phase, ion-pairing, HPLC using a microbore Inertsil-ODS{trademark} column. The HPLC column effluent was introduced into an ICP/MS system using a direct injection nebulizer (DIN). Detection limits of less than 1 pg were readily obtained for each arsenic species. Internal standards are recommended to increase accuracy and precision. Soil samples spiked with arsenic oxide, sodium arsenate, dimethylarsinic acid (DMAA), and chlorovinyl arsenious acid (CVAA) were extracted, identified and quantified with the HPLC/ICP/MS system. The soil samples were analyzed in support of the analytical needs of a thermal desorption treatability study being conducted at the RMA.

  18. Calculation of the non-inductive current profile in high-performance NSTX plasmas

    Science.gov (United States)

    Gerhardt, S. P.; Fredrickson, E.; Gates, D.; Kaye, S.; Menard, J.; Bell, M. G.; Bell, R. E.; Le Blanc, B. P.; Kugel, H.; Sabbagh, S. A.; Yuh, H.

    2011-03-01

    The constituents of the current profile have been computed for a wide range of high-performance plasmas in NSTX (Ono et al 2000 Nucl. Fusion 40 557); these include cases designed to maximize the non-inductive fraction, pulse length, toroidal-β or stored energy. In the absence of low-frequency MHD activity, good agreement is found between the reconstructed current profile and that predicted by summing the independently calculated inductive, pressure-driven and neutral beam currents, without the need to invoke any anomalous beam ion diffusion. Exceptions occur, for instance, when there are toroidal Alfvén eigenmode avalanches or coupled m/n = 1/1 + 2/1 kink-tearing modes. In these cases, the addition of a spatially and temporally dependent fast-ion diffusivity can reduce the core beam current drive, restoring agreement between the reconstructed profile and the summed constituents, as well as bringing better agreement between the simulated and measured neutron emission rate. An upper bound on the fast-ion diffusivity of ~0.5-1 m2 s-1 is found in 'MHD-free' discharges, based on the neutron emission, the time rate of change in the neutron signal when a neutral beam is stepped and reconstructed on-axis current density.

  19. Calculation of the Non-Inductive Current Profile in High-Performance NSTX Plasmas

    International Nuclear Information System (INIS)

    Gerhardt, S.P.; Fredrickson, E.; Gates, D.; Kaye, S.; Menard, J.; Bell, M.G.; Bell, R.E.; Le Blanc, B.P.; Kugel, H.; Sabbagh, S.A.; Yuh, H.

    2011-01-01

    The constituents of the current profile have been computed for a wide range of high-performance plasmas in NSTX [M. Ono, et al., Nuclear Fusion 40, 557 (2000)]; these include cases designed to maximize the non-inductive fraction, pulse length, toroidal-β, or stored energy. In the absence of low-frequency MHD activity, good agreement is found between the reconstructed current profile and that predicted by summing the independently calculated inductive, pressure-driven, and neutral beam currents, without the need to invoke any anomalous beam ion diffusion. Exceptions occur, for instance, when there are toroidal Alfven eigenmode avalanches or coupled m/n=1/1+2/1 kink-tearing modes. In these cases, the addition of a spatially and temporally dependent fast ion diffusivity can reduce the core beam current drive, restoring agreement between the reconstructed profile and the summed constituents, as well as bringing better agreement between the simulated and measured neutron emission rate. An upper bound on the fast ion diffusivity of ∼0.5-1 m 2 /sec is found in 'MHD-free' discharges, based on the neutron emission, time rate of change of the neutron signal when a neutral beam is stepped, and reconstructed on-axis current density.

  20. Investigation of lower hybrid current drive during H-mode in EAST tokamak

    International Nuclear Information System (INIS)

    Li Miao-Hui; Ding Bo-Jiang; Kong Er-Hua; Zhang Lei; Zhang Xin-Jun; Qian Jin-Ping; Yan Ning; Han Xiao-Feng; Shan Jia-Fang; Liu Fu-Kun; Wang Mao; Xu Han-Dong; Wan Bao-Nian

    2011-01-01

    H-mode discharges with lower hybrid current drive (LHCD) alone are achieved in EAST divertor plasma over a wide parameter range. These H-mode discharges are characterized by a sudden drop in D α emission and a spontaneous rise in main plasma density. Good lower hybrid (LH) coupling during H-mode is obtained by putting the plasma close to the antenna and by injecting D 2 gas from a pipe near the grill mouse. The analysis of lower hybrid current drive properties shows that the LH deposition profile shifts off axis during H-mode, and current drive (CD) efficiency decreases due to the increase in density. Modeling results of H-mode discharges with a general ray tracing code GENRAY are reported. (physics of gases, plasmas, and electric discharges)

  1. Offset linear scaling for H-mode confinement

    International Nuclear Information System (INIS)

    Miura, Yukitoshi; Tamai, Hiroshi; Suzuki, Norio; Mori, Masahiro; Matsuda, Toshiaki; Maeda, Hikosuke; Takizuka, Tomonori; Itoh, Sanae; Itoh, Kimitaka.

    1992-01-01

    An offset linear scaling for the H-mode confinement time is examined based on single parameter scans on the JFT-2M experiment. Regression study is done for various devices with open divertor configuration such as JET, DIII-D, JFT-2M. The scaling law of the thermal energy is given in the MKSA unit as W th =0.0046R 1.9 I P 1.1 B T 0.91 √A+2.9x10 -8 I P 1.0 R 0.87 P√AP, where R is the major radius, I P is the plasma current, B T is the toroidal magnetic field, A is the average mass number of plasma and neutral beam particles, and P is the heating power. This fitting has a similar root mean square error (RMSE) compared to the power law scaling. The result is also compared with the H-mode in other configurations. The W th of closed divertor H-mode on ASDEX shows a little better values than that of open divertor H-mode. (author)

  2. Pellet fuelling and ELMy H-mode physics at JET

    International Nuclear Information System (INIS)

    Horton, L.D.

    2001-01-01

    As the reference operating regime for ITER, investigations of the ELMy H-mode have received high priority in the JET experimental programme. Recent experiments have concentrated in particular on operation simultaneously at high density and high confinement using high field side (HFS) pellet launch. The enhanced fuelling efficiency of HFS pellet fuelling is found to scale favourably to a large machine such as JET. The achievable density of ELMy H-mode plasmas in JET has been significantly increased using HFS fuelling although at the expense of confinement degradation back to L-mode levels. Initial experiments using control of the pellet injection frequency have shown that density and confinement can simultaneously be increased close to the values necessary for ITER. The boundaries of the available ELMy H-mode operational space have also been extensively explored. The power necessary to maintain the high confinement normally associated with ELMy H-mode operation is found to be substantially higher than the H-mode threshold power. The compatibility of ELMy H-modes with divertor operation acceptable for a fusion device has been studied. Narrow energy scrape-off widths are measured which place stringent limits on divertor power handling. Deuterium and tritium codeposition profiles are measured to be strongly in/out asymmetric. Successful modelling of these profiles requires the inclusion of the (measured) scrape-off layer flows and of the production in the divertor of hydrocarbon molecules with sticking coefficients below unity. Helium exhaust and compression are found to be within the limits sufficient for a reactor. (author)

  3. Power requirements for superior H-mode confinement on Alcator C-Mod: experiments in support of ITER

    International Nuclear Information System (INIS)

    Hughes, J.W.; Reinke, M.L.; Terry, J.L.; Brunner, D.; Greenwald, M.; Hubbard, A.E.; LaBombard, B.; Lipschultz, B.; Ma, Y.; Wolfe, S.; Wukitch, S.J.; Loarte, A.

    2011-01-01

    Power requirements for maintaining sufficiently high confinement (i.e. normalized energy confinement time H 98 ≥ 1) in H-mode and its relation to H-mode threshold power scaling, P th , are of critical importance to ITER. In order to better characterize these power requirements, recent experiments on the Alcator C-Mod tokamak have investigated H-mode properties, including the edge pedestal and global confinement, over a range of input powers near and above P th . In addition, we have examined the compatibility of impurity seeding with high performance operation, and the influence of plasma radiation and its spatial distribution on performance. Experiments were performed at 5.4 T at ITER relevant densities, utilizing bulk metal plasma facing surfaces and an ion cyclotron range of frequency waves for auxiliary heating. Input power was scanned both in stationary enhanced D α (EDA) H-modes with no large edge localized modes (ELMs) and in ELMy H-modes in order to relate the resulting pedestal and confinement to the amount of power flowing into the scrape-off layer, P net , and also to the divertor targets. In both EDA and ELMy H-mode, energy confinement is generally good, with H 98 near unity. As P net is reduced to levels approaching that in L-mode, pedestal temperature diminishes significantly and normalized confinement time drops. By seeding with low-Z impurities, such as Ne and N 2 , high total radiated power fractions are possible, along with substantial reductions in divertor heat flux (>4x), all while maintaining H 98 ∼ 1. When the power radiated from the confined versus unconfined plasma is examined, pedestal and confinement properties are clearly seen to be an increasing function of P net , helping to unify the results with those from unseeded H-modes. This provides increased confidence that the power flow across the separatrix is the correct physics basis for ITER extrapolation. The experiments show that P net /P th of one or greater is likely to lead to H

  4. High temperature L- and H-mode confinement in JET

    International Nuclear Information System (INIS)

    Balet, B.; Boyd, D.A.; Campbell, D.J.

    1990-01-01

    The energy confinement properties of low density, high ion temperature L- and H-mode plasmas are investigated. For L-mode plasmas it is shown that, although the global confinement is independent of density, the energy confinement in the central region is significantly better at low densities than at higher densities. The improved confinement appears to be associated with the steepness of the density gradient. For the H-mode phase, although the confinement at the edge is dramatically improved, which is once again associated with the steep density gradient in the edge region, the central confinement properties are essentially the same as for the standard L-mode. The results are compared in a qualitative manner with the predictions of the ion temperature gradient instability theory and appear to be in disagreement with some aspects of this theory. (author). 13 refs, 15 figs

  5. Simultaneous determination of dapsone, monoacetyldapsone and pyrimethamine in whole blood and plasma by high-performance liquid chromatography

    DEFF Research Database (Denmark)

    Lemnge, M M; Rønn, A; Flachs, H

    1993-01-01

    A sensitive, selective and rapid reversed-phase high-performance liquid chromatographic method was developed for the simultaneous analysis of dapsone, monoacetyldapsone and pyrimethamine in human whole blood and plasma. The procedure involved extraction of the compounds and the internal standard...

  6. Application of divertor cryopumping to H-mode density control in DIII-D

    International Nuclear Information System (INIS)

    Mahdavi, M.A.; Ferron, J.R.; Hyatt, A.W.

    1993-11-01

    In this paper we describe the method and the results of experiments where a unique in-vessel cryopump-baffle system was used to control density of H-mode plasmas. We were able to independently regulate current and density of ELMing H-mode plasmas, each over a range of factor two, and measure the H-mode confinement scaling with plasma density and current. With a modest pumping speed of ∼40 kl/s, particle exhaust rates as high as 2 x 10 22 atom/s -1 have been observed

  7. The H-mode operational window as determined from the ITER H-mode database

    International Nuclear Information System (INIS)

    Ryter, F.; Kardaun, O.J.W.F.; Stroth, U.

    1994-01-01

    The H-mode is a promising regime for fusion reactors and it is essential to be able to predict its operational window in future devices. The 'H-Mode Database Working Group' started in 1992 to gather, analyze and compare H-mode threshold data from several divertor tokamaks so that predictions could be made. The database and first results were presented and the threshold database has been improved and extended since. The work has two objectives: 1) to predict the minimum heating power necessary to reach the H-mode in future devices, 2) to contribute to physics studies of the L-H transition. (author) 11 refs., 2 figs

  8. Determination of boldine in plasma by high-performance liquid chromatography.

    Science.gov (United States)

    Speisky, H; Cassels, B K; Nieto, S; Valenzuela, A; Nuñez-Vergara, L J

    1993-02-26

    A sensitive method for the determination of boldine in blood plasma is described. The procedure involves a direct pH-buffered chloroform extraction of boldine from blood plasma, followed by its assay under isocratic conditions by HPLC with UV detection. The extraction recovery is excellent, and sensitivity and precision of the method are very high, when applied to plasma samples containing pharmacologically relevant concentrations of boldine.

  9. Proceeding of JSPS-CAS Core University Program seminar on production and control of high performance plasmas with advanced plasma heating and diagnostic systems

    International Nuclear Information System (INIS)

    Gao Xiang; Morita, Shigeru

    2011-02-01

    The JSPS-CAS Core University Program (CUP) seminar on 'Production and control of high performance plasmas with advanced plasma heating and diagnostic systems' took place in Guilin Bravo Hotel, Guilin, China, 1-4 November 2010. This seminar was organized in the framework of CUP in the field of plasma and nuclear fusion. Two special talks and 46 oral talks were presented in the seminar including 36 Chinese, 18 Japanese and 4 Korean attendees. Production and control of high performance plasmas is a crucial issue for realizing an advanced nuclear fusion reactor in addition to developments of advanced plasma heating and diagnostics. This seminar was motivated along the issues. Results in the field of fusion experiments obtained through CUP activities during recent two years were summarized. Possible direction of future collaboration and further encouragement of scientific activity of younger scientists were also discussed in this seminar with future experimental plans in both countries. (author)

  10. Proceeding of JSPS-CAS core university program seminar on production and control of high performance plasmas with advanced plasma heating and diagnostic systems

    International Nuclear Information System (INIS)

    Gao Xiang; Morita, Shigeru

    2009-01-01

    The JSPS-CAS Core University Program (CUP) seminar on 'Production and control of high performance plasmas with advanced plasma heating and diagnostic systems' took place in Shiner hotel, Lijiang, China, 4-7 November 2008. This seminar was organized in the framework of CUP in the field of plasma and nuclear fusion. One special talk and 34 oral talks were presented in the seminar including 16 Japanese attendees. Production and control of high performance plasmas is a crucial issue for realizing an advanced nuclear fusion reactor in addition to developments of advanced plasma heating and diagnostics. This seminar was motivated along the issues. Results obtained from CUP activities during recent four years were summarized. Several crucial issues to be resolved near future were also extracted in this seminar. The 31 of the papers are indexed individually. (J.P.N.)

  11. Discriminant analysis to predict the occurrence of ELMs in H-mode discharges

    International Nuclear Information System (INIS)

    Kardaun, O.J.W.F.; Itoh, S.; Itoh, K.; Kardaun, J.W.P.F.

    1993-08-01

    After an exposition of its theoretical background, discriminant analysis is applied to the H-mode confinement database to find the region in plasma parameter space in which H-mode with small ELMs (Edge Localized Modes) is likely to occur. The boundary of this region is determined by the condition that the probability of appearance of such a type of H-mode, as a function of the plasma parameters, should be (1) larger than some threshold value and (2) larger than the corresponding probability for other types of H-mode (i.e., H-mode without ELMs or with giant ELMs). In practice, the discrimination has been performed for the ASDEX, JET and JFT-2M tokamaks (a) using four instantaneous plasma parameters (injected power P inj , magnetic field B t , plasma current I p and line averaged electron density (n-bar e ) and (b) taking also memory effects of the plasma and the distance between the plasma and the wall into account, while using variables that are normalised with respect to machine size. Generally speaking, it is found that there is a substantial overlap between the region of H-mode with small ELMs and the region of the two other types of H-mode. However, the ELM-free and the giant ELM H-modes relatively rarely appear in the region, that, according to the analysis, is allocated to small ELMs. A reliable production of H-mode with only small ELMs seems well possible by choosing this regime in parameter space. In the present study, it was not attempted to arrive at a unified discrimination across the machines. So, projection from one machine to another remains difficult, and a reliable determination of the region where small ELMs occur still requires a training sample from the device under consideration. (author) 53 refs

  12. Behaviour of impurities during the H-mode in JET

    International Nuclear Information System (INIS)

    Gianella, R.; Behringer, K.; Denne, B.; Gottardi, N.; Hellermann, M. von; Morgan, P.D.; Pasini, D.; Stamp, M.F.

    1989-01-01

    In additionally-heated tokamak discharges, the H-mode phases are reported to display, together with a better energy confinement, a longer global containment time for particles. In particular, steep gradients of electron density and temperature are sustained in the outer region of the plasma column. This enhanced performance is observed especially in discharges in which the activity of edge localized modes (ELMs) is low or absent. High confinement and accumulation of metallic impurities, which quickly give raise to terminal disruptions have been described under similar conditions. In JET H-modes very long impurity confinement times are also observed. However the experimental condition is somewhat more favourable since quiescent H-modes are obtained lasting much longer than the energy confinement times and the radiation from metals is generally negligible. The dominant impurities are normally carbon and oxygen, the latter generally accounting for half or more of the power radiated from the bulk plasma. During the X-point operation the effective influx of carbon into the discharge, which is normally in close correlation with that of deuterium, is substantially reduced while the influx of oxygen, whose production mechanisms is believed to be of a chemical nature, does not show significant variations. (author) 5 refs., 4 figs

  13. An emerging understanding of H-mode discharges in tokamaks

    International Nuclear Information System (INIS)

    Groebner, R.J.

    1992-12-01

    A remarkable degree of consistency of experimental results from tokamaks throughout the world has developed with regard to the phenomenology of the transition from L-mode to H-mode confinement in tokamaks. The transition is initiated in a narrow layer at the plasma periphery where density fluctuations are suppressed and steep gradients of temperature and density form in a region with large first and second radial derivatives in the υ E → = (E x B)/B 2 flow velocity. These results are qualitatively consistent with theories which predict suppression of fluctuations by shear or curvature in υE. The required υE flow is generated very rapidly when the magnitude of the heating power or of an externally imposed radial current exceed threshold values and several theoretical models have been developed to explain the observed changes in the υE flow. After the transition occurs, the altered boundary conditions enable the development of improved confinement in the plasma interior on a confinement time scale. The resulting H-mode discharge has typically twice the confinement of L-mode discharges and regimes of further improved confinement have been obtained in some H-mode scenarios

  14. High performance solution-deposited amorphous indium gallium zinc oxide thin film transistors by oxygen plasma treatment

    KAUST Repository

    Nayak, Pradipta K.

    2012-05-16

    Solution-deposited amorphous indium gallium zinc oxide (a-IGZO) thin film transistors(TFTs) with high performance were fabricated using O2-plasma treatment of the films prior to high temperature annealing. The O2-plasma treatment resulted in a decrease in oxygen vacancy and residual hydrocarbon concentration in the a-IGZO films, as well as an improvement in the dielectric/channel interfacial roughness. As a result, the TFTs with O2-plasma treated a-IGZO channel layers showed three times higher linear field-effect mobility compared to the untreated a-IGZO over a range of processing temperatures. The O2-plasma treatment effectively reduces the required processing temperature of solution-deposited a-IGZO films to achieve the required performance.

  15. Statistical study of TCV disruptivity and H-mode accessibility

    International Nuclear Information System (INIS)

    Martin, Y.; Deschenaux, C.; Lister, J.B.; Pochelon, A.

    1997-01-01

    Optimising tokamak operation consists of finding a path, in a multidimensional parameter space, which leads to the desired plasma characteristics and avoids hazards regions. Typically the desirable regions are the domain where an L-mode to H-mode transition can occur, and then, in the H-mode, where ELMs and the required high density< y can be maintained. The regions to avoid are those with a high rate of disruptivity. On TCV, learning the safe and successful paths is achieved empirically. This will no longer be possible in a machine like ITER, since only a small percentage of disrupted discharges will be tolerable. An a priori knowledge of the hazardous regions in ITER is therefore mandatory. This paper presents the results of a statistical analysis of the occurrence of disruptions in TCV. (author) 4 figs

  16. Overview of H-mode studies in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Baker, D.R,; Allen, S.L.

    1994-01-01

    A major portion of the DIII-D program includes studies of the L-H transition, of the VH-mode, of particle transport and control and of the power-handling capability of a diverter. Significant progress has been made in all of these areas and the purpose of this paper is to summarize the major results obtained during the last two years. An increased understanding of the origin of improved confinement in H-mode and in VH-mode discharges has been obtained, good impurity control has been achieved in several operating scenarios, studies of helium transport provide encouraging results from the point of view of reactor design, an actively pumped diverter chamber has controlled the density in H-mode discharges and a radiative diverter is a promising technique for controlling the heat flux from the main plasma

  17. H-mode edge rotation in W7-AS

    International Nuclear Information System (INIS)

    Hirsch, M.; Baldzuhn, J.; Ehmler, H.; Grigull, P.; Maassberg, H.; McCormick, K.; Wagner, F.; Wobig, H.

    2005-01-01

    In W7-AS three regimes of improved confinement exist which base on negative radial electric fields at the plasma edge resulting there from ion-root conditions of the ambipolar radial fluxes. Experimental control besides the magnetic configuration is given via the edge density profile i.e. the recycling and fuelling conditions. However, the ordering element seems to be the radial electric field profile (respectively its shear) and its interplay with the gradients of ion temperature and density. At low to medium densities the so called optimum confinement regime occurs with maximum density gradients located well inside the plasma boundary and large negative values of E r extending deep in the bulk plasma. For a large inner fraction of the bulk the ion temperature can be sufficiently high that ion transport conditions already can be explained by neoclassics. This regime delivers maximum values of T i , τ e and n τ e T i . Density gradients located right inside the plasma boundary result in the classical H-mode phenomena reminiscent to other toroidal devices with the capability of an edge layer with nearly complete suppression of turbulence either quasi stationary (in a quiescent H-mode) or intermittently (in between ELMs). At even higher densities and highly collisional plasmas with the maximum of ∇n shifted to or even out of the plasma boundary the High Density H-mode (HDH) opens access to steady state conditions with no measurable impurity accumulation. These improved confinement regimes are accessed and left via significant transitions of the transport properties albeit these transitions occur on rather different timescales. A comprehensive picture of improved edge confinement regimes in W7-AS is drawn based on the assumption that a weak edge bounded transport barrier resulting from the ion root conditions (thus E r <0) is the ground state of the (turbulent) edge plasma and already behaves as a barrier for anomalous transport. On top of that the classical H-mode

  18. Plasma-spraying synthesis of high-performance photocatalytic TiO2 coatings

    International Nuclear Information System (INIS)

    Takahashi, Yasuo; Maeda, Masakatsu; Ohmori, Akira; Shibata, Yoshitaka; Miyano, Yasuyuki; Murai, Kensuke

    2014-01-01

    Anatase (A-) TiO 2 is a photocatalytic material that can decompose air-pollutants, acetaldehyde, bacteria, and so on. In this study, three kinds of powder (A-TiO 2 without HAp, TiO 2 + 10mass%HAp, and TiO 2 +30mass%HAp, where HAp is hydroxyapatite and PBS is polybutylene succinate) were plasma sprayed on biodegradable PBS substrates. HAp powder was mixed with A-TiO 2 powder by spray granulation in order to facilitate adsorption of acetaldehyde and bacteria. The crystal structure was almost completely maintained during the plasma spray process. HAp enhanced the decomposition of acetaldehyde and bacteria by promoting adsorption. A 10mass% HAp content was the most effective for decomposing acetaldehyde when plasma preheating of the PBS was not carried out before the plasma spraying. The plasma preheating of PBS increased the yield rate of the spray process and facilitated the decomposition of acetaldehyde by A-TiO 2 coatings without HAp. HAp addition improved photocatalytic sterilization when plasma preheating of the PBS was performed

  19. Plasma transport properties at the L-H transition and high performance phase of JET discharges

    Energy Technology Data Exchange (ETDEWEB)

    Balet, B; Cordey, J G; Erba, M; Jones, T T.C.; Lomas, P J; Smeulders, P; Springmann, E M; Stubberfield, P M; Taroni, A; Thomsen, K [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Parail, V V [Kurchatov Institute, Moscow (Russian Federation)

    1994-07-01

    Numerical analysis are performed which show that both electron and ion thermal diffusivities are reduced by one order of magnitude everywhere, not only in a narrow region near separatrix during the L-H transition. There is no separate H-VH transition on JET, this transition coincides with the cessation of ELMs. In the ELM free phase ion transport in the core is close to its neoclassical value, but probably rises towards plasma edge (however still remaining much less than it was in L-mode). The best agreement with experiment is obtained with the model which simultaneously takes into account both the global reduction of Bohm type anomalous transport in plasma core and formation of temperature pedestal near plasma edge. (authors). 6 refs., 5 figs.

  20. High density high performance plasma with internal diffusion barrier in Large Helical Device

    International Nuclear Information System (INIS)

    Sakamoto, R.; Kobayashi, M.; Miyazawa, J.

    2008-10-01

    A attractive high density plasma operational regime, namely an internal diffusion barrier (IDB), has been discovered in the intrinsic helical divertor configuration on the Large Helical Device (LHD). The IDB which enables core plasma to access a high density/high pressure regime has been developed. It is revealed that the IDB is reproducibly formed by pellet fueling in the magnetic configurations shifted outward in major radius. Attainable central plasma density exceeds 1x10 21 m -3 . Central pressure reaches 1.5 times atmospheric pressure and the central β value becomes fairly high even at high magnetic field, i.e. β(0)=5.5% at B t =2.57 T. (author)

  1. Analysis of 26-hydroxycholesterol in plasma by high performance liquid chromatography

    International Nuclear Information System (INIS)

    Kou, I.L.; Holmes, R.P.

    1986-01-01

    A method utilizing HPLC has been developed for the analysis of 26-hydroxycholesterol in plasma. The method involves initially saponifying samples for estimation of the total sterol or extracting samples with acetonitrile to estimate the free sterol. This is followed by a C-18 Sep Pak fractionation of the extracts, further purification on a Nova Pak C-18 HPLC column, and finally by quantitation on a silicic acid HPLC column by measuring the absorbance at 210 nm. Losses of sterol during this multi-step procedure were determined by estimating the recovery of 3 H-26-hydroxycholesterol added to samples before extraction or saponification. The reproducibility of the method was evaluated by repetitive analysis of one plasma sample. The coefficient of variation was 6.8% for six analyses. In agreement with the mass spectrometric determinations of Javitt et al. The authors observed total plasma levels in the range of 140-260 ng/ml in young adult humans, rats, and rabbits. In the plasma of older human patients undergoing coronary by-pass surgery levels ranged from 335-950 ng/ml, suggesting that an increase in the level of 26-hydroxycholesterol is either age-related or related to the development of acute atherosclerosis

  2. Plasma nitriding induced growth of Pt-nanowire arrays as high performance electrocatalysts for fuel cells

    NARCIS (Netherlands)

    Du, S.; Lin, K.; Malladi, S.R.K.; Lu, Y.; Sun, S.; Xu, Q.; Steinberger-Wilckens, R.; Dong, H.

    2014-01-01

    In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support

  3. JET Radiative Mantle Experiments in ELMy H-Mode

    International Nuclear Information System (INIS)

    Budny, R.; Coffey, I.; Dumortier, P.; Grisolia, C.; Strachan, J.D.

    1999-01-01

    Radiative mantle experiments were performed on JET ELMy H-mode plasmas. The Septum configuration was used where the X-point is embedded into the top of the Septum. Argon radiated 50% of the input power from the bulk plasma while Z eff rose from an intrinsic level of 1.5 to about 1.7 due to the injected Argon. The total energy content and global energy confinement time decreased 15% when the impurities were introduced. In contrast, the effective thermal diffusivity in the core confinement region (r/a = .4--.8) decreased by 30%. Usually, JET ELMy H-mode plasmas have confinement that is correlated to the edge pedestal pressure. The radiation lowered the edge pedestal and consequently lowered the global confinement. Thus the confinement was changed by a competition between the edge pedestal reduction lowering the confinement and the weaker RI effect upon the core transport coefficients raising the confinement. The ELM frequency increased from 10 Hz Type I ELMs, to 200 Hz type III ELMs. The energy lost by each ELM reduced to 0.5% of the plasma energy content

  4. A simple high-performance liquid chromatography for the determination of linezolid in human plasma and saliva.

    Science.gov (United States)

    Hara, Shuuji; Uchiyama, Masanobu; Yoshinari, Masami; Matsumoto, Taichi; Jimi, Shiro; Togawa, Atsushi; Takata, Tohru; Takamatsu, Yasushi

    2015-09-01

    Linezolid is an antimicrobial agent for the treatment of multiresistant Gram-positive infections. A practical high-performance liquid chromatography method was developed for the determination of linezolid in human plasma and saliva. Linezolid and an internal standard (o-ethoxybenzamide) were extracted from plasma and saliva with ethyl acetate and analyzed on a Capcell Pak C18 MG column with UV detection at 254 nm. The calibration curve was linear through the range 0.5-50 µg/mL using a 200 μL sample volume. The intra- and interday precisions were all plasma and 5.60% for saliva. The accuracies ranged from 98.8 to 110% for both matrices. The mean recoveries of linezolid were 80.8% for plasma and 79.0% for saliva. This method was used to determine the plasma and saliva concentrations of linezolid in healthy volunteers who were orally administered a 600 mg dose of linezolid. Our liquid-liquid extraction procedure is easy and requires a small volume of plasma or saliva (200 μL). This small volume can be advantageous in clinical pharmacokinetic studies, especially if children participate. Copyright © 2015 John Wiley & Sons, Ltd.

  5. High performance liquid chromatographic assay for the quantitation of total glutathione in plasma

    Science.gov (United States)

    Abukhalaf, Imad K.; Silvestrov, Natalia A.; Menter, Julian M.; von Deutsch, Daniel A.; Bayorh, Mohamed A.; Socci, Robin R.; Ganafa, Agaba A.

    2002-01-01

    A simple and widely used homocysteine HPLC procedure was applied for the HPLC identification and quantitation of glutathione in plasma. The method, which utilizes SBDF as a derivatizing agent utilizes only 50 microl of sample volume. Linear quantitative response curve was generated for glutathione over a concentration range of 0.3125-62.50 micromol/l. Linear regression analysis of the standard curve exhibited correlation coefficient of 0.999. Limit of detection (LOD) and limit of quantitation (LOQ) values were 5.0 and 15 pmol, respectively. Glutathione recovery using this method was nearly complete (above 96%). Intra-assay and inter-assay precision studies reflected a high level of reliability and reproducibility of the method. The applicability of the method for the quantitation of glutathione was demonstrated successfully using human and rat plasma samples.

  6. High performance with modified magnetic shear in JET DD and DT plasmas

    International Nuclear Information System (INIS)

    Gormezano, C.

    1999-01-01

    Internal transport barriers (ITBs) in which both the ion thermal diffusivity and electron thermal diffusivity are substantially reduced have been observed in JET. Such discharges have been obtained with DD and DT plasmas. Central ion temperatures of 40 keV and plasma pressure gradients of 10 6 Pa/m were observed in DT plasmas leading to a fusion triple product n i0 T i0 τ E 1.1 x 10 21 m -3 ·keV·s and producing 8.2 MW of fusion power. ITBs have been produced in both the MkII and the new Gas Box divertor configuration with similar behaviour. With the Gas Box divertor an L mode edge has so far only been produced using edge radiation cooling. For the first time, ITBs have been triggered by radiating about 40% of the power with a krypton puff. A possible scaling of the power needed to trigger an ITB with magnetic field is suggested. (author)

  7. A quick and easy high performance liquid chromatography method for evaluation of cefixime in human plasma

    Directory of Open Access Journals (Sweden)

    Hossein Danafar

    2015-12-01

    Full Text Available Cefixime is essential member of orally energetic third generation cephalosporin and has tremendous activity aligned with many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation.  A simple and available reversed-phase HPLC method with UV detection has been urbanized and validate for cefixime evaluate in human plasma using a C18 analytical column and a mobile phase of tetrabutylammonium hydroxide (pH 6.5-acetonitrile (3:1 v/v. The detection wavelength was 280 nm. To method observed major linear response-concentration association all through the cefixime concentration range of 15-100 ng/ml, with the average accuracy within-run and between-run values of 97.29% and 99.27%. The average drug recovery from plasma was 98.2% throughout the linear concentration range. The limits of detection (LOD and quantitation (LOQ of the method were 5 and 15 ng/ml, respectively. The method is quick, easy, very steady and precise for the partition, assignment, evaluation of cefixime in human plasma.

  8. Recent progresses on high performance steady-state plasmas in the superconducting tokamak TRIAM-1M

    International Nuclear Information System (INIS)

    Itoh, Satoshi; Sato, Kohnosuke; Nakamura, Kazuo

    1999-01-01

    The overview of TRIAM-1M experiments is described. The up-to-date issues for steady-state operation are presented through the experience of the achievement of super ultra long tokamak discharges (SULD) sustained by lower hybrid current drive (LHCD) over 2 hours. The importance of the control of an initial phase of plasma, the avoidance of the concentration of huge heat load, the wall conditioning, and abrupt stop of the long discharges are proposed as the indispensable issues for the achievement of the steady-state operation of tokamak. A high ion temperature (HIT) discharge fully sustained by 2.45 GHz LHCD with both high ion temperature and steep temperature gradient is successfully demonstrated for longer than 1 min in the limiter configuration. The HIT discharges can be obtained in the narrow window of density and position. Moreover, the avoidance of the concentration of heat load on a limiter is the key point for the achievement and its long sustainment. As the effective thermal insulation between the wall and the plasma is improved on the single null configuration, HIT discharges with peak ion temperature > 5keV and steeper gradient up to 85 keV/m can be achieved by the exquisite control of density and position. The plasmas with high κ ∼1.5 can be also demonstrated for longer than 1 min. The current profile is also well-controlled for about 2 orders in magnitude longer than the current diffusion time using combined LHCD. The serious damage to the material of the first wall caused by energetic neutral particles produced via charge exchange process is also described. As the neutral particles cannot be affected by magnetic field, this damage by neutral particles must be avoided by the new technique. (author)

  9. Plasma Treatment of Carbon Nanotubes Applied to Improve the High Performance of Carbon Nanofiber Supercapacitors

    International Nuclear Information System (INIS)

    Chang, Wei-Min; Wang, Cheng-Chien; Chen, Chuh-Yung

    2015-01-01

    Graphical abstract: This article focused on improving conductivity of carbon nanofibers (CNFs) by added plasma-treatment carbon nanotubes (CNTs). The plasma modification method avoided the destruction of the length and structure of the CNTs and maintained their good electrical properties. Through this method, the relation between conductivity and surface activity site of CNFs was investigated. The results shown that he CNTs-MA added to the CNFs successfully maintained the activity sites on the surface of the CNFs and provide a good electric network to enhance the supercapacitor performance of the CNFs. - Highlights: • The plasma modification method avoided the destruction of the length and structure of the CNTs and maintained their good electrical properties. • The highest conductivity of the CNTs-MA/CNF was 5.2 s/cm at 2.5 wt.% of CNTs-MA addition. It was increased to 8.7 time. • The CNTs-MA added to the CNFs successfully maintained the activity sites on the surface of the CNFs and provide a good electric network to enhance the supercapacitor performance of the CNFs. The highest capacitance was 382 F/g. - Abstract: Plasma-treatment carbon nanotubes (CNTs) grafted with maleic anhydride (MA) were embedded in polyacryonitrile nanofibers via electrospinning and subsequently carbonizated at 800 °C to fabricate carbon nanofibers (CNFs). The grafted degree of MA on CNTs (CNTs-MA) was determined via Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The morphology, surface composition and conductivity of the CNTs-MA/CNF were characterized using electron microscopy, X-ray photoelectron and electrochemical impedance spectroscopy, respectively. CNTs-MA not only affected the conductivity of the CNFs but also the types of the nitrogen functional groups that could be represented as active sites on the CNFs to enhance the performance of the supercapacitors. When 2.5 wt.% CNTs-MA was embedded in the CNFs, the highest conductivity was obtained at

  10. Microturbulence and Flow Shear in High-performance JET ITB Plasma; TOPICAL

    International Nuclear Information System (INIS)

    R.V. Budny; A. Andre; A. Bicoulet; C. Challis; G.D. Conway; W. Dorland; D.R. Ernst; T.S. Hahm; T.C. Hender; D. McCune; G. Rewoldt; S.E. Sharapov

    2001-01-01

    The transport, flow shear, and linear growth rates of microturbulence are studied for a Joint European Torus (JET) plasma with high central q in which an internal transport barrier (ITB) forms and grows to a large radius. The linear microturbulence growth rates of the fastest growing (most unstable) toroidal modes with high toroidal mode number are calculated using the GS2 and FULL gyrokinetic codes. These linear growth rates, gamma (subscript lin) are large, but the flow-shearing rates, gamma (subscript ExB) (dominated by the toroidal rotation contribution) are also comparably large when and where the ITB exists

  11. Recent progress in EAST towards long-pulse high-performance operations

    International Nuclear Information System (INIS)

    Wang Liang; Wan Baonian; Li Jiangang; Guo Houyang; Liang Yunfeng; Xu Guosheng; Gong Xianzu; Garofalo, Andrea

    2015-01-01

    Significant advance has been made in EAST on both physics and technology fronts towards the long-pulse operation of high-confinement plasma regimes since the last IAEA-FEC. The EAST capabilities have been greatly upgraded, including the significantly enhanced CW H and CD system with up to 26 MW heating power, more than 70 diagnostics, ITER-like W monoblock top divertor, two internal cryo-pumps and RMP coils, enabling EAST to investigate long-pulse H-mode operation with dominant electron heating and low input torque, and to address some of critical issues for ITER. Remarkable physics progress has been made on controlling transient ELM and stationary divertor heat fluxes, e.g., ELM mitigation/suppression/pacing with LHCD and SMBI, real-time Li aerosol injection for long pulse ELM-free H-mode, edge coherent mode for continuous pedestal particle and power removal, and the combination of LHCD and SMBI to actively modify the stationary power footprint by regulating the divertor conditions. In the 2014 commissioning campaign, long-pulse high-performance H-mode up to 28 s has been obtained with H_9_8∼1.15, i.e., about ∼ 30% higher than the record 32 s H-mode achieved in the 2012 campaign. Other key new experimental achievements are: (1) high performance H-mode with β_N ∼ 2 and plasma stored energy ∼ 220 kJ, (2) high performance operation with core T_e ∼ 4.5 keV, (3) H-mode plasma enabled by NBI alone or LHW+NBI modulation for the first time in EAST, (4) demonstration of a quasi snowflake divertor configuration, (5) new findings on L-H transition and pedestal physics. (author)

  12. "Determination of mycophenolic acid in human plasma by high-performance liquid chromatography"

    Directory of Open Access Journals (Sweden)

    "Mehdi Ahadi Barzoki

    2005-05-01

    Full Text Available A simple, sensitive and reproducible HPLC method is presented for determination of mycophenolic acid(MPA in human plasma. Samples were prepared after precipitation of the plasma protein by addition of acetonitrile and naproxen was used as internal standard (I.S.. Separation was performed by reversedphase HPLC, using a Hamilton PRP-C18 Column, 51% acetonitrile and 49% potassium phosphate buffer (20 mM at pH 3.0 as mobile phase, flow rate of 1.0 ml/min, and UV detection at 215 nm. MPA and I.S. had retention times of 7.5 and 11.35 min, respectively. The method showed an acceptable linearity in the range of 0.1µg/ml-40µg/ml with r2 of .9992. The concentration of 0.1µg/ml was determined as quantification limit. Mean absolute recovery was 94.8%. The mean intra- and inter-day reproducibility of method was 4.6 and 11.4% respectively.

  13. A high-performance channel engineered charge-plasma-based MOSFET with high-κ spacer

    Science.gov (United States)

    Shan, Chan; Wang, Ying; Luo, Xin; Bao, Meng-tian; Yu, Cheng-hao; Cao, Fei

    2017-12-01

    In this paper, the performance of graded channel double-gate MOSFET (GC-DGFET) that utilizes the charge-plasma concept and a high-κ spacer is investigated through 2-D device simulations. The results demonstrate that GC-DGFET with high-κ spacer can effectively improve the ON-state driving current (ION) and reduce the OFF-leakage current (IOFF). We find that reduction of the initial energy barrier between the source and channel is the origin of this ION enhancement. The reason for the IOFF reduction is identified to be the extension of the effective channel length owing to the fringing field via high-κ spacers. Consequently, these devices offer enhanced performance by reducing the total gate-to-gate capacitance (Cgg) and decreasing the intrinsic delay (τ).

  14. Toward High-Performance Coatings for Biomedical Devices: Study on Plasma-Deposited Fluorocarbon Films and Ageing in PBS

    Directory of Open Access Journals (Sweden)

    Diego Mantovani

    2010-03-01

    Full Text Available High performance coatings tailored to medical devices represent a recognised approach to modulate surface properties. Plasma-deposited fluorocarbon films have been proposed as a potential stent coating. Previous studies have shown promising adhesion properties: the 35 nm-thick film sustained plastic deformation up to 25% such as induced during the clinical implantation. In this study, the compositional and morphological changes of plasma-deposited fluorocarbon films were examined during ageing in a pseudo-physiological medium, a phosphate buffer solution (PBS, by angle-resolved XPS, FT-IR data and AFM images. The evolution of the ageing process is discussed: defluorination and crosslinking yielded an oxidized protective top layer onto the films, which showed further degradation.

  15. ELMs IN DIII-D HIGH PERFORMANCE DISCHARGES

    International Nuclear Information System (INIS)

    TURNBULL, A.D; LAO, L.L; OSBORNE, T.H; SAUTER, O; STRAIT, E.J; TAYLOR, T.S; CHU, M.S; FERRON, J.R; GREENFIELD, C.M; LEONARD, A.W; MILLER, R.L; SNYDER, P.B; WILSON, H.R; ZOHM, H

    2003-01-01

    A new understanding of edge localized modes (ELMs) in tokamak discharges is emerging [P.B. Snyder, et al., Phys. Plasmas, 9, 2037 (2002)], in which the ELM is an essentially ideal magnetohydrodynamic (MHD) instability and the ELM severity is determined by the radial width of the linearly unstable MHD kink modes. A detailed, comparative study of the penetration into the core of the respective linear instabilities in a standard DIII-D ELMing, high confinement mode (H-mode) discharge, with that for two relatively high performance discharges shows that these are also encompassed within the framework of the new model. These instabilities represent the key, limiting factor in extending the high performance of these discharges. In the standard ELMing H-mode, the MHD instabilities are highly localized in the outer few percent flux surfaces and the ELM is benign, causing only a small temporary drop in the energy confinement. In contrast, for both a very high confinement mode (VH-mode) and an H-mode with a broad internal transport barrier (ITB) extending over the entire core and coalesced with the edge transport barrier, the linearly unstable modes penetrate well into the mid radius and the corresponding consequences for global confinement are significantly more severe. The ELM accordingly results in an irreversible loss of the high performance

  16. Simulation of electron thermal transport in H-mode discharges

    International Nuclear Information System (INIS)

    Rafiq, T.; Pankin, A. Y.; Bateman, G.; Kritz, A. H.; Halpern, F. D.

    2009-01-01

    Electron thermal transport in DIII-D H-mode tokamak plasmas [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] is investigated by comparing predictive simulation results for the evolution of electron temperature profiles with experimental data. The comparison includes the entire profile from the magnetic axis to the bottom of the pedestal. In the simulations, carried out using the automated system for transport analysis (ASTRA) integrated modeling code, different combinations of electron thermal transport models are considered. The combinations include models for electron temperature gradient (ETG) anomalous transport and trapped electron mode (TEM) anomalous transport, as well as a model for paleoclassical transport [J. D. Callen, Nucl. Fusion 45, 1120 (2005)]. It is found that the electromagnetic limit of the Horton ETG model [W. Horton et al., Phys. Fluids 31, 2971 (1988)] provides an important contribution near the magnetic axis, which is a region where the ETG mode in the GLF23 model [R. E. Waltz et al., Phys. Plasmas 4, 2482 (1997)] is below threshold. In simulations of DIII-D discharges, the observed shape of the H-mode edge pedestal is produced when transport associated with the TEM component of the GLF23 model is suppressed and transport given by the paleoclassical model is included. In a study involving 15 DIII-D H-mode discharges, it is found that with a particular combination of electron thermal transport models, the average rms deviation of the predicted electron temperature profile from the experimental profile is reduced to 9% and the offset to -4%.

  17. High performance with modified shear in JET D-D and D-T plasmas

    International Nuclear Information System (INIS)

    2001-01-01

    The observation of Internal Transport Barriers (ITBs) in which ion thermal diffusivity is reduced to a neo- classical level and the electron thermal diffusivity is substantially reduced has been made in JET with the optimised shear scenario with the MkII divertor both in D-D and in D-T. Central ion temperatures of 40keV and plasma pressure gradient of 10 6 Pa/m were observed in D-T leading to a fusion triple product n i T i τ E =1x10 21 m -3 keVs and 8.2MW of fusion power. ITBs have also been produced in the new Gas Box divertor configuration with a similar behaviour. With the new divertor an L-mode edge has only been produced using edge radiation cooling. For the first time, ITBs have been triggered by radiating about 40% of the power with a krypton puff. A tentative scaling of the power needed to trigger an ITB with magnetic field is indicated. (author)

  18. Plasma nitriding induced growth of Pt-nanowire arrays as high performance electrocatalysts for fuel cells

    Science.gov (United States)

    Du, Shangfeng; Lin, Kaijie; Malladi, Sairam K.; Lu, Yaxiang; Sun, Shuhui; Xu, Qiang; Steinberger-Wilckens, Robert; Dong, Hanshan

    2014-09-01

    In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significantly promoting the uniform growth of tiny Pt nuclei which directs the growth of ultrathin single-crystal Pt nanowire (2.5-3 nm in diameter) arrays, forming a three-dimensional (3D) nano-architecture. Pt nanowire arrays in-situ grown on the large-area gas diffusion layer (GDL) (5 cm2) can be directly used as the catalyst electrode in fuel cells. The unique design brings in an extremely thin electrocatalyst layer, facilitating the charge transfer and mass transfer properties, leading to over two times higher power density than the conventional Pt nanoparticle catalyst electrode in real fuel cell environment. Due to the similar challenges faced with other nanostructures and the high availability of ASP for other material surfaces, this work will provide valuable insights and guidance towards the development of other new nano-architectures for various practical applications.

  19. Improved method for the determination of serotonin in plasma by high-performance liquid chromatography using on-line sample pre-treatment

    NARCIS (Netherlands)

    Takkenberg, B.; Endert, E.; van Ingen, H. E.; Ackermans, M.

    1991-01-01

    An improved method for the determination of serotonin in platelet-rich plasma (PRP) and platelet-poor plasma (PPP), by reversed-phase high-performance liquid chromatography with electrochemical detection and direct plasma injection, is described. The chromatographic system comprises a strong

  20. Ohmic H-mode and confinement in TCV

    International Nuclear Information System (INIS)

    Moret, J.-M.; Anton, M.; Barry, S.

    1995-01-01

    The unique flexibility of TCV for the creation of a wide variety of plasma shapes has been exploited to address some aspects of tokamak physics for which the shape may play an important role. The electron energy confinement time in limited ohmic L-mode plasmas whose elongation and triangularity have been varied (κ = 1.3 - 1.9, δ 0.1 - 0.7) has been observed to improve with elongation as κ 0.5 but to degrade with triangularity as (1 - 0.8 δ), for fixed safety factor. Ohmic H-modes have been obtained in several diverted and limited configurations, with some of the diverted discharges featuring large ELMs whose effects on the global confinement have been quantified. These effects depend on the configuration: in double null (DN) equilibria, a single ELM expels on average 2%, 6% and 2.5% of the particle, impurity and thermal energy content respectively, whilst in single null (SN) configurations, the corresponding numbers are 3.5%, 7% and 9%, indicative of larger ELM effects. The presence of absence of large ELMs in DN discharges has been actively controlled in a single discharge by alternately forcing one or other of the two X-points to lie on the separatrix, permitting stationary density and impurity content (Z eff ∼ 1.6) in long H-modes (1.5 s). (Author)

  1. Ohmic H-mode and confinement in TCV

    International Nuclear Information System (INIS)

    Moret, J.M.; Anton, M.; Barry, S.

    1995-01-01

    The unique flexibility of TCV for the creation of a wide variety of plasma shapes has been exploited to address some aspects of tokamak physics for which the shape may play an important role. The electron energy confinement time in limited ohmic L-mode plasmas whose elongation and triangularity have been varied, has been observed to improve with elongation as κ 0.5 but to degrade with triangularity as (1-0.8 δ), for fixed safety factor. Ohmic H-modes have been obtained in several diverted and limited configurations, with some of the diverted discharges featuring large ELMs whose effects on the global confinement have been quantified. These effects depend on the configuration: in double null (DN) equilibria, a single ELM expels on average 2%, 6% and 2.5% of the particle, impurity and thermal energy content respectively, whilst in single null (SN) configurations, the corresponding numbers are 3.5%, 7% and 9%, indicative of larger ELM effects. The presence or absence of large ELMs in DN discharges has been actively controlled in a single discharge by alternately forcing one or other of the two X-points to lie on the separatrix, permitting stationary density and impurity content (Z eff ≅1.6) in long H-modes (1.5 s). (author) 9 figs., 9 refs

  2. Transport of impurities during H-mode pulses in JET

    International Nuclear Information System (INIS)

    Giannella, R.; Gottardi, N.; Mompean, F.; Mori, H.; Pasini, D.; Stork, D.; Barnsley, R.; Hawkes, N.C.; Lawson, K.

    1990-01-01

    The transport of impurities during the H-mode is very different from that observed in the other regimes. This is clearly evident in the quiescent discharges where the confinement time of impurities τ I are measured in all the quiescent H-mode discharges in spite of the variety of impurity behavior observed corresponding to different plasma parameters and operating scenarios. The condition of the machine has an influence on the role played by the various impurities, but this does not seem to affect the flow patterns of these ions substantially. In particular oxygen, which was often detected as the dominant radiator, can be reduced to a negligible fraction by He conditioning of the carbon X-point tiles or limiters or by evaporating beryllium in the vacuum vessel. Nevertheless the behaviour of the residual impurities in otherwise similar discharges remains substantially unchanged. The transport patterns appear in fact to be affected by the plasma parameters and their profiles. In particular, two extreme transport regimes are presented in the following. These discharges have been modelled with the aid of a recently developed fully time-dependent impurity transport code using heuristic profiles for the impurity diffusion D and the convection velocity v. (author) 4 refs., 5 figs

  3. Simple and sensitive high performance liquid chromatographic method for the simultaneous quantitation of the phenylalanine in human plasma

    Directory of Open Access Journals (Sweden)

    Hossein Danafar

    2015-09-01

    Full Text Available Phenylalanine (Phe is the most reliable indicator for the diagnosis of phenylketonuria (PKU. The purpose of this study is to establish a reliable and quick method for the assignment of Phe in peripheral capillary blood from newborns and children by high performance liquid chromatography with ultraviolet detection (HPLC-UV. PKU is an inborn error of metabolism characterized by the inability of the body to use Phe. A rapid and sensitive high performance liquid chromatographic (HPLC method has been developed for determination of Phe in plasma. The method uses a protein precipitation step with sulfosalicilic acid for sample preparation by separation on a Nova-pack C18 column using sodium acetate buffer and acetonitrile (94: 6 v/v adjusted to pH 6.5 with glacial acetic acid. The eluted peaks detected by a UV detector was set at wavelength of 215 nm. The method was validated in the range of Phe concentrations from 0.1 to 20 µg/ml. The limits of detection (LOD and quantitation (LOQ of the method were 0.05 and 0.1 µg/ml, respectively. The average drug recovery from plasma was 88.60 percent throughout the linear concentration range., with the average within-run and between-run accuracy values of 103.3 and 115.350, respectively. The method is quick, easy, very steady and precise for the screen, assignment, and evaluation of Phe in human plasma by HPLC, which is particularly a useful way for screening and diagnosis of PKU and monitoring of a diet therapy.

  4. Ballooning stability analysis of JET H-mode discharges

    International Nuclear Information System (INIS)

    O'Brien, D.P.; Galvao, R.; Keilhacker, M.; Lazzaro, E.; Watkins, M.L.

    1989-01-01

    Previous studies of the stability of a large aspect ratio model equilibrium to ideal MHD ballooning modes have shown that across the bulk of the plasma there exist two marginally stable values of the pressure gradient parameter α. These define an unstable zone which separates the first (small α) stable region from the second (large α) stable region. Close to the separatrix, however, the first and second regions can coalesce when the surface averaged current density, Λ, exceeds a critical value. The plasma in this region is then stable to ballooning modes at all values of the pressure gradient. In this paper we extend these results to JET H-mode equilibria using a finite aspect ratio ballooning formalism, and assess the relevance of ideal ballooning stability in these discharges. In particular we analyse shot 15894 at time 56 sec. which is 1.3 s into the H-phase. (author) 4 refs., 4 figs

  5. Quantitation of Pyrrole-Imidazole Polyamide in Rat Plasma by High-Performance Liquid Chromatography Coupled with UV Detection

    Directory of Open Access Journals (Sweden)

    Tomonori Kamei

    2012-01-01

    Full Text Available A simple and robust method using high-performance liquid chromatography with UV detection was developed and validated for the determination of six pyrrole-imidazole (PI polyamides (HN.49, TGF-β1f, TGF-β1t, HN.50f, HN.50t, and LOX-1 in rat plasma. After the plasma proteins were precipitated with methanol containing phenacetin as an internal standard, the analytes were separated on a Luna C18 (2 (5 μm, 4.6×150 mm. Calibration curves were linear over the range of 0.5 to 200 μg/mL for HN.49, 0.25 to 200 μg/mL for TGF-β1f, TGF-β1t, HN.50t, and LOX-1, 1 to 200 μg/mL for HN.50f in rat plasma. The inter- and intraday precision were below 15%, and the accuracy was within 15% at the quality controls. The validated method was successfully applied to sample analysis for the pharmacokinetic study.

  6. Optimized method for the determination of itopride in human plasma by high-performance liquid chromatography with fluorimetric detection.

    Science.gov (United States)

    Ptácek, Pavel; Klíma, Josef; Macek, Jan

    2009-03-15

    A high-performance liquid chromatographic method with fluorescence detection for the determination of itopride in human plasma is reported. The sample preparation was based on liquid-liquid extraction of itopride from plasma with t-butylmethylether and dichloromethane (70:30, v/v) mixture followed by a back extraction of the analyte to the phosphate buffer (pH 3.2). Liquid chromatography was performed on an octadecylsilica column (55 mm x 4 mm, 3 microm particles), the mobile phase consisted of acetonitrile-triethylamine-15 mM dihydrogenpotassium phosphate (14.5:0.5:85, v/v/v), pH of the mobile phase was adjusted to 4.8. The run time was 3 min. The fluorimetric detector was operated at 250/342 nm (excitation/emission wavelength). Naratriptan was used as the internal standard. The limit of quantitation was 9.5 ng/ml using 0.5 ml of plasma. The method precision and inaccuracy were less than 8%. The assay was applied to the analysis of samples from a bioequivalence study.

  7. Operational range and transport barrier of the H-mode in the stellarator W7-AS

    International Nuclear Information System (INIS)

    Hirsch, M.; Amadeo, P.; Anton, M.; Baldzuhn, J.; Brakel, R.; Bleuel, J.; Fiedler, S.; Geist, T.; Grigull, P.; Hartfuss, H.J.; Jaenicke, R.; Kick, M.; Kisslinger, J.; Koponen, J.; Wagner, F.; Weller, A.; Wobig, H.; Zoletnik, S.; Holzhauer, E.

    1998-01-01

    In W7-AS the H-mode is characterized by an edge transport barrier localized in the first 3-4 cm inside the separatrix. In the ELMy H-mode preceding the quiescent state ELMs appear as a sudden breakdown of the edge transport barrier in coincidence with bursts of fluctuations. Between ELMs fluctuations are identical to those of the quiescent H-mode. The operational range of the quiescent H-mode is determined by narrow windows of the edge rotational transform and a threshold edge electron density. In contrast, ELM-like events are observed for a variety of plasma conditions by far exceeding the narrow operational windows for the quiescent state. (author)

  8. Effect of Gas Fueling Location on H-mode Access in NSTX

    International Nuclear Information System (INIS)

    Maingi, R.; Bell, M.; Bell, R.; Biewer, T.; Bush, C.; Chang, C.S.; Gates, D.; Kaye, S.; Kugel, H.; LeBlanc, B.; Maqueda, R.; Menard, J.; Mueller, D.; Raman, R.; Sabbagh, S.; Soukhanovskii, V.

    2003-01-01

    The dependence of H-mode access on the poloidal location of the gas injection source has been investigated in the National Spherical Torus Experiment (NSTX). We find that gas fueling from the center stack midplane area produces the most reproducible H-mode access with generally the lowest L-H threshold power in lower single-null configuration. The edge toroidal rotation velocity is largest (in direction of the plasma current) just before the L-H transition with center stack midplane fueling, and then reverses direction after the L-H transition. Simulation of these results with a 2-D guiding-center Monte Carlo neoclassical transport code is qualitatively consistent with the trends in the measured velocities. Double-null discharges exhibit H-mode access with gas fueling from either the center stack midplane or center stack top locations, indicating a reduced sensitivity of H-mode access on fueling location in that shape

  9. Determination of five antiarrhythmic drugs in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography.

    Science.gov (United States)

    Jouyban, Abolghasem; Sorouraddin, Mohammad Hossein; Farajzadeh, Mir Ali; Somi, Mohammad Hossein; Fazeli-Bakhtiyari, Rana

    2015-03-01

    A fast and sensitive high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection was developed and validated for the simultaneous quantitation of five antiarrhythmic drugs (metoprolol, propranolol, carvedilol, diltiazem, and verapamil) in human plasma samples. It involves dispersive liquid-liquid microextraction (DLLME) of the desired drugs from 660 µL plasma and separation using isocratic elution with UV detection at 200 nm. The complete separation of all analytes was achieved within 7 min. Acetonitrile (as disperser solvent) resulting from the protein precipitation procedure was mixed with 100 µL dichloromethane (as an extraction solvent) and rapidly injected into 5 mL aqueous solution (pH 11.5) containing 1% (w/v), NaCl. After centrifugation, the sedimented phase containing enriched analytes was collected and evaporated to dryness. The residue was re-dissolved in 50 µL de-ionized water (acidified to pH 3) and injected into the HPLC system for analysis. Under the optimal conditions, the enrichment factors and extraction recoveries ranged between 4.4-10.8 and 33-82%, respectively. The suggested method was linear (r(2) ≥0.997) over a dynamic range of 0.02-0.80 µg mL(-1) in plasma. The intra- and inter-days relative standard deviation (RSD%) and relative error (RE%) values of the method were below 20%, which shows good precision and accuracy. Finally, this method was applied to the analysis of real plasma samples obtained from the patients treated with these drugs. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. H-mode pedestal characteristics on MAST

    International Nuclear Information System (INIS)

    Kirk, A; Counsell, G F; Arends, E; Meyer, H; Taylor, D; Valovic, M; Walsh, M; Wilson, H

    2004-01-01

    The H-mode pedestal characteristics on the mega ampere spherical tokamak (MAST) are measured in a variety of disconnected double null discharges and the effect of edge localized modes (ELMs) on the pedestal is presented. The edge density pedestal width in spatial co-ordinates is similar on both the inboard and outboard sides. Neutral penetration may be able to explain the density pedestal width but it alone cannot explain the characteristics of the temperature pedestal. The data from MAST can be used to improve temperature pedestal width scalings by extending the ranges in pedestal collisionality, magnetic field, elongation and aspect ratio studied by other machines. Convective transport is found to dominate energy losses during ELMs and the fractional loss of pedestal energy during an ELM on MAST correlates better with SOL ion transit time than with pedestal collisionality

  11. Expression for the thermal H-mode energy confinement time under ELM-free conditions

    International Nuclear Information System (INIS)

    Ryter, F.; Gruber, O.; Kardaun, O.J.W.F.; Menzler, H.P.; Wagner, F.; Schissel, D.P.; DeBoo, J.C.; Kaye, S.M.

    1992-07-01

    The design of future tokamaks, which are supposed to reach ignition with the H-mode, requires a reliable scaling expression for the H-mode energy confinement time. In the present work, an H-mode scaling expression for the thermal plasma energy confinement time has been developed by combining data from four existing divertor tokamaks, ASDEX, DIII-D, JET and PBX-M. The plasma conditions, which were as similar as possible to ensure a coherent set of data, were ELM-free deuterium discharges heated by deuterium neutral beam injection. By combining four tokamaks, the parametric dependence of the thermal energy confinement on the main plasma parameters, including the three main geometrical variables, was determined. (orig./WL)

  12. Cobalamin speciation using reversed-phase micro-high-performance liquid chromatography interfaced to inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Yanes, Enrique G.; Miller-Ihli, Nancy J.

    2004-01-01

    Micro-high-performance liquid chromatography interfaced to inductively coupled plasma mass spectrometry was optimized for the determination and separation of a mixture of cobalt containing species. Four cobalamin species (cyanocobalamin, hydroxocobalamin, methylcobalamin, and 5'-deoxyadenosylcobalamin) representing the various forms of vitamin B12 as well as the harmful corrinoid analogue cobinamide dicyanide were separated using reversed-phase microcapillary chromatography with columns containing C18 packing material with a 2-μm particle size. Selection of organic solvents for the separation took into consideration compatibility with the inductively coupled plasma mass spectrometer being used for element specific detection. Optimized method conditions included use of a methanol gradient and make-up solution for the nebulizer. Some issues associated with dead volume were overcome by the extension of the gradient program. The total analysis time was 52 min. The column-to-column variability was evaluated and was found to be very reasonable (9% RSD on average), confirming that this method is rugged and that the technology should be easily transferred to other laboratories

  13. New approach to the determination phosphorothioate oligonucleotides by ultra high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Studzińska, Sylwia; Mounicou, Sandra; Szpunar, Joanna; Łobiński, Ryszard; Buszewski, Bogusław

    2015-01-15

    This text presents a novel method for the separation and detection of phosphorothioate oligonucleotides with the use of ion pair ultra high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry The research showed that hexafluoroisopropanol/triethylamine based mobile phases may be successfully used when liquid chromatography is coupled with such elemental detection. However, the concentration of both HFIP and TEA influences the final result. The lower concentration of HFIP, the lower the background in ICP-MS and the greater the sensitivity. The method applied for the analysis of serum samples was based on high resolution inductively coupled plasma mass spectrometry. Utilization of this method allows determination of fifty times lower quantity of phosphorothioate oligonucleotides than in the case of quadrupole mass analyzer. Monitoring of (31)P may be used to quantify these compounds at the level of 80 μg L(-1), while simultaneous determination of sulfur is very useful for qualitative analysis. Moreover, the results presented in this paper demonstrate the practical applicability of coupling LC with ICP-MS in determining phosphorothioate oligonucleotides and their metabolites in serum within 7 min with a very good sensitivity. The method was linear in the concentration range between 0.2 and 3 mg L(-1). The limit of detection was in the range of 0.07 and 0.13 mg L(-1). Accuracy varied with concentration, but was in the range of 3%. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. [Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection].

    Science.gov (United States)

    Yang, Yingying; Chen, Mei; Kuang, Yushan; Ye, Liming; Zhang, Wensheng

    2013-06-01

    A high performance liquid chromatographic method coupled with fluorometric detection has been developed for the determination of atracurium and its major metabolite laudanosine in dog plasma. The separation of atracurium and laudanosine was performed on an Agilent Eclipse Plus C18 column, and the mobile phase consisted of 0.03 mol/L dipotassium hydrogen phosphate and acetonitrile (72: 28, v/v) at a flow rate of 1.0 mL/min. Verapamil was used as the internal standard. The sample was extracted by dichloromethane, concentrated and dissolved in the mobile phase. The detection is performed at 240 nm for excitation and 320 nm for emission. The results showed that the linear concentration ranges of the calibration curve were 25 - 5 000 microg/L for atracurium (r = 0.999 0), and 25 - 6 000 microg/L for laudanosine (r = 0.9984). The recoveries were 92.1% - 109.5%. The limits of detection were 3 microg/L for atracurium and 1 microg/L for laudanosine. The RSDs of intra-day and inter-day were less than 10%. The stability tests under various conditions have been performed. The method is specific, sensitive and accurate in the determination of atracurium and laudanosine, and also can be used for the pharmacokinetic investigations of atracurium and laudanosine in plasma.

  15. Gyrokinetic Stability Studies of the Microtearing Mode in the National Spherical Torus Experiment H-mode

    International Nuclear Information System (INIS)

    Baumgaertel J.A., Redi M.H., Budny R.V., Rewoldt G., Dorland W.

    2005-01-01

    Insight into plasma microturbulence and transport is being sought using linear simulations of drift waves on the National Spherical Torus Experiment (NSTX), following a study of drift wave modes on the Alcator C-Mod Tokamak. Microturbulence is likely generated by instabilities of drift waves, which cause transport of heat and particles. Understanding this transport is important because the containment of heat and particles is required for the achievement of practical nuclear fusion. Microtearing modes may cause high heat transport through high electron thermal conductivity. It is hoped that microtearing will be stable along with good electron transport in the proposed low collisionality International Thermonuclear Experimental Reactor (ITER). Stability of the microtearing mode is investigated for conditions at mid-radius in a high density NSTX high performance (H-mode) plasma, which is compared to the proposed ITER plasmas. The microtearing mode is driven by the electron temperature gradient, and believed to be mediated by ion collisions and magnetic shear. Calculations are based on input files produced by TRXPL following TRANSP (a time-dependent transport analysis code) analysis. The variability of unstable mode growth rates is examined as a function of ion and electron collisionalities using the parallel gyrokinetic computational code GS2. Results show the microtearing mode stability dependence for a range of plasma collisionalities. Computation verifies analytic predictions that higher collisionalities than in the NSTX experiment increase microtearing instability growth rates, but that the modes are stabilized at the highest values. There is a transition of the dominant mode in the collisionality scan to ion temperature gradient character at both high and low collisionalities. The calculations suggest that plasma electron thermal confinement may be greatly improved in the low-collisionality ITER

  16. Analysis of drugs of abuse in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography.

    Science.gov (United States)

    Fernández, P; Regenjo, M; Bermejo, A M; Fernández, A M; Lorenzo, R A; Carro, A M

    2015-04-01

    Opioids and cocaine are widely used at present, both for recreational purposes and as drugs of abuse. This raises the need to develop new analytical methods specifically designed for the simultaneous detection of several drugs of abuse in biological samples. In this work, dispersive liquid-liquid microextraction (DLLME) was assessed as a new sample treatment for the simultaneous extraction of morphine (MOR), 6-acetylmorphine (6AM), cocaine (COC), benzoylecgonine (BZE) and methadone (MET) from human plasma. Preliminary assays were done before developing an experimental design based on a Uniform Network Doehlert which allowed the optimum extraction conditions to be identified, namely: a volume of extractant solvent (chloroform) and dispersant solvent (acetonitrile) of 220 µl and 3.2 ml, respectively; 0.2 g of NaCl as a salting-out additive; pH 10.6 and ultrasound stirring for 3.5 min. The resulting extracts were analyzed by high-performance liquid chromatography with photodiode array detection (HPLC-PDA), using an XBridge® RP18 column (250 × 4.6 mm i.d., 5 µm particle size). Calibration graphs were linear over the concentration range 0.1-10 µg ml⁻¹, and detection limits ranged from 13.9 to 28.5 ng ml⁻¹. Precision calculated at three different concentration levels in plasma was included in the range 0.1-6.8% RSD. Recoveries of the five drugs were all higher than 84% on average. Finally the proposed method was successfully applied to 22 plasma samples from heroin, cocaine and/or methadone users, and the most frequently detected drug was benzoylecgonine, followed by methadone, cocaine and morphine. Copyright © 2014 John Wiley & Sons, Ltd.

  17. Development of plasma-treated polypropylene nonwoven-based composites for high-performance lithium-ion battery separators

    International Nuclear Information System (INIS)

    Li, Xiaofei; He, Jinlin; Wu, Dazhao; Zhang, Mingzu; Meng, Juwen; Ni, Peihong

    2015-01-01

    (290 wt%) and ionic conductivity (1.76 mS cm −1 ). More importantly, the LiFePO 4 /Li half-cell assembled with PHS-10 composite separator displays a good C-rate performance, which shows an enhancement in the chemical stability and discharge capacity. The capacity keeps above 150 mA h g −1 after 100 charge–discharge cycles. These performances endow this composite membrane as a promising candidate for high-performance lithium-ion battery separators

  18. H-mode profile parametrization for extrapolation and control

    International Nuclear Information System (INIS)

    Imre, K.; Riedel, K.S.; Schissel, D.P.; Schunke, B.

    1996-01-01

    A steady-state ELMy H-mode profile data set of 68 DIII-D discharges and 74 JET discharges is fitted with an error of 7-8%. The advantages of a parametrization of the plasma profiles in terms of a semi-parametric representation, T(ρ, I p , n-bar, B t , P L , R), are described. The shape of the temperature profile depends almost exclusively upon the size, R and q 95 , with a secondary dependence on the heating power. The density profile depends primarily upon q95 with a secondary dependence on n-bar. The line-average temperature T-bar e scales as n-bar -0.31 instead of T-bar∼''n-bar'' -1.0 . The predicted ITER temperature is T-bar = 17.1 keV. (Author)

  19. Progress in quantifying the edge physics of the H mode regime in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Baker, D.R.; Burrell, K.H.

    2001-01-01

    Edge conditions in DIII-D are being quantified in order to provide insight into the physics of the H mode regime. Several studies show that electron temperature is not the key parameter that controls the L-H transition. Gradients of edge temperature and pressure are much more promising candidates for elements of such parameters. They systematically increase during the L phases of discharges which make a transition to H mode, and these increases are typically larger than the increases in the underlying quantities. The quality of H mode confinement is strongly correlated with the height of the H mode pedestal for the pressure. The gradient of the pressure is limited by MHD modes, in particular by ideal kink ballooning modes with finite mode number n. For a wide variety of discharges, the width of the barrier for electron pressure is well described by a relationship that is proportional to (β p ped ) 1/2 . A new regime of confinement, called the quiescent H mode, which provides steady state operation with no ELMs, low radiated power and normal H mode confinement, has been discovered. A coherent edge MHD mode provides adequate particle transport to control the plasma density while permitting the pressure pedestal to remain almost identical to that observed in ELMing discharges. (author)

  20. High performance liquid chromatographic-mass spectrometric assay for the quantitation of BMS-204352 in dog K(3)EDTA plasma.

    Science.gov (United States)

    Yao, Ming; Mantha, Subbarao; Shah, Vinod R; Vachharajani, Nimish N; Arnold, Mark E; Pursley, Janice M; Srinivas, Nuggehally R

    2002-05-01

    A high performance liquid chromatographic-mass spectrometric (LC/MS) assay was developed and validated for the determination of BMS-204352 in dog K(3)EDTA plasma. A 0.5 mL aliquot of control plasma was spiked with BMS-204352 and internal standard (IS) and buffered with 1 mL of 5 mM ammonium acetate. The mixture was then extracted with 3 mL of toluene. After separation and evaporation of the organic phase to dryness using nitrogen at 40 degrees C, the residue was reconstituted in the mobile phase and 25 microL of the sample were injected onto a Hypersil C(18) column (2 x 50 mm; 3 microm) at a flow rate of 0.5 mL/min. The mobile phase was consisted of two solvent mixtures (A and B). Solvent A was composed of 5 mM ammonium acetate and 0.1% triethylamine in 75:25 v/v water:methanol, pH adjusted to 5.5 with glacial acetic acid, and solvent B was 5 mM ammonium acetate in methanol. A linear gradient system was used to elute the analytes. The mass spectrometer was programmed to admit the de-protonated molecules at m/z 352.7 (IS) and m/z 357.9 (BMS-204352). Standard curves of BMS-204352 were linear (r(2) > or = 0.998) over the concentration range of 0.5-1000 ng/mL. The mean predicted quality control (QC) concentrations deviated less than 5.1% from the corresponding nominal values (ie 4, 80, 400 and 2000 ng/mL); the within- and between-assay precision of the assay were within 5.5% relative standard deviation. Stability of BMS-204352 was confirmed after at least three freeze/thaw cycles and BMS-204532 was stable in dog plasma when stored frozen at or below -20 degrees C for at least 16 weeks in spiked QC samples and for at least 4 1/2 weeks for in vivo study samples. BMS-204352 and IS were stable in the injection solvent at room temperature for at least 24 h. The assay was applied to delineate the pharmacokinetic disposition of BMS-204352 in dogs following a single intravenous dose administration. In conclusion, the assay is accurate, precise, specific, sensitive and

  1. Gyrokinetic Calculations of Microturbulence and Transport for NSTX and Alcator-CMOD H-modes

    International Nuclear Information System (INIS)

    Redi, M.H.; Dorland, W.; Bell, R.; Bonoli, P.; Bourdelle, C.; Candy, J.; Ernst, D.; Fiore, C.; Gates, D.; Hammett, G.; Hill, K.; Kaye, S.; LeBlanc, B.; Menard, J.; Mikkelsen, D.; Rewoldt, G.; Rice, J.; Waltz, R.; Wukitch, S.

    2003-01-01

    Recent H-mode experiments on NSTX [National Spherical Torus Experiment] and experiments on Alcator-CMOD, which also exhibit internal transport barriers (ITB), have been examined with gyrokinetic simulations with the GS2 and GYRO codes to identify the underlying key plasma parameters for control of plasma performance and, ultimately, the successful operation of future reactors such as ITER [International Thermonuclear Experimental Reactor]. On NSTX the H-mode is characterized by remarkably good ion confinement and electron temperature profiles highly resilient in time. On CMOD, an ITB with a very steep electron density profile develops following off-axis radio-frequency heating and establishment of H-mode. Both experiments exhibit ion thermal confinement at the neoclassical level. Electron confinement is also good in the CMOD core

  2. Simultaneous determination of eperisone hydrochloride and paracetamol in mouse plasma by high performance liquid chromatography-photodiode array detector.

    Science.gov (United States)

    Locatelli, Marcello; Cifelli, Roberta; Di Legge, Cristina; Barbacane, Renato Carmine; Costa, Nicola; Fresta, Massimo; Celia, Christian; Capolupo, Carlo; Di Marzio, Luisa

    2015-04-03

    This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini C18 column (4.6 mm × 250 mm; 5 μm particle size) using a gradient elution mode with a run time of 15 min, comprising re-equilibration, at 60°C (± 1°C). The method was validated over the concentration range from 0.5 to 25 μg/mL for eperisone hydrochloride and paracetamol, in mouse plasma. Ciprofloxacin was used as Internal Standard. Results from assay validations show that the method is selective, sensitive and robust. The limit of quantification of the method was 0.5 μg/mL for eperisone hydrochloride and paracetamol, and matrix-matched standard curves showed a good linearity, up to 25 μg/mL with correlation coefficients (r(2))≥ 0.9891. In the entire analytical range the intra and inter-day precision (RSD%) values were ≤ 1.15% and ≤ 1.46% for eperisone hydrochloride, and ≤ 0.35% and ≤ 1.65% for paracetamol. For both analytes the intra and inter-day trueness (bias%) values ranged, respectively, from -5.33% to 4.00% and from -11.4% to -4.00%. The method was successfully tested in pharmacokinetic studies after oral administration in mouse. Furthermore, the application of this method results in a significant reduction in terms of animal number, dosage, and improvement in speed, rate of analysis, and quality of pharmacokinetic parameters related to serial blood sampling. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring.

    Science.gov (United States)

    Park, Youngja H; Lee, Kichun; Soltow, Quinlyn A; Strobel, Frederick H; Brigham, Kenneth L; Parker, Richard E; Wilson, Mark E; Sutliff, Roy L; Mansfield, Keith G; Wachtman, Lynn M; Ziegler, Thomas R; Jones, Dean P

    2012-05-16

    High-performance metabolic profiling (HPMP) by Fourier-transform mass spectrometry coupled to liquid chromatography gives relative quantification of thousands of chemicals in biologic samples but has had little development for use in toxicology research. In principle, the approach could be useful to detect complex metabolic response patterns to toxicologic exposures and to detect unusual abundances or patterns of potentially toxic chemicals. As an initial study to develop these possible uses, we applied HPMP and bioinformatics analysis to plasma of humans, rhesus macaques, marmosets, pigs, sheep, rats and mice to determine: (1) whether more chemicals are detected in humans living in a less controlled environment than captive species and (2) whether a subset of plasma chemicals with similar inter-species and intra-species variation could be identified for use in comparative toxicology. Results show that the number of chemicals detected was similar in humans (3221) and other species (range 2537-3373). Metabolite patterns were most similar within species and separated samples according to family and order. A total of 1485 chemicals were common to all species; 37% of these matched chemicals in human metabolomic databases and included chemicals in 137 out of 146 human metabolic pathways. Probability-based modularity clustering separated 644 chemicals, including many endogenous metabolites, with inter-species variation similar to intra-species variation. The remaining chemicals had greater inter-species variation and included environmental chemicals as well as GSH and methionine. Together, the data suggest that HPMP provides a platform that can be useful within human populations and controlled animal studies to simultaneously evaluate environmental exposures and biological responses to such exposures. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  4. Determination of metabolite of nicergoline in human plasma by high-performance liquid chromatography and its application in pharmacokinetic studies

    Directory of Open Access Journals (Sweden)

    Rong Zheng

    2012-02-01

    Full Text Available A fast, simple and sensitive high performance liquid chromatographic (HPLC method has been developed for determination of 10α-methoxy-6-methyl ergoline-8β-methanol (MDL, a main metabolite of nicergoline in human plasma. One-step liquid–liquid extraction (LLE with diethyl ether was employed as the sample preparation method. Tizanidine hydrochloride was selected as the internal standard (IS. Analysis was carried out on a Diamonsil ODS column (150 mm×4.6 mm, 5 μm using acetonitrile–ammonium acetate (0.1 mol/L (15/85, v/v as mobile phase at detection wavelength of 224 nm. The calibration curves were linear over the range of 2.288–73.2 ng/mL with a lower limit of quantitation (LLOQ of 2.288 ng/mL. The intra- and inter-day precision values were below 13% and the recoveries were from 74.47% to 83.20% at three quality control levels. The method herein described was successfully applied in a randomized crossover bioequivalence study of two different nicergoline preparations after administration of 30 mg in 20 healthy volunteers. Keywords: Nicergoline, 10α-methoxy-6-methylergoline-8β-methanol (MDL, HPLC, Plasma-drug concentration, Bioequivalence study

  5. Energy confinement in Ohmic H-mode in TUMAN-3M

    International Nuclear Information System (INIS)

    Andrejko, M.V.; Askinazi, L.G.; Golant, V.E.; Kornev, V.A.; Lebedev, S.V.; Levin, L.S.; Tukachinsky, A.S.

    1997-01-01

    The spontaneous transition from Ohmically heated limiter discharges into the regime with improved confinement termed as ''Ohmic H-mode'' has been investigated in ''TUMAN-3''. The typical signatures of H-mode in tokamaks with powerful auxiliary heating have been observed: sharp drop of D α radiation with simultaneous increase in the electron density and stored energy, suppression of the density fluctuations and establishing the steep gradient near the periphery. In 1994 new vacuum vessel had been installed in TUMAN-3 tokamak. The vessel has the same sizes as old one (R 0 =0.55 m, a 1 =0.24 m). New vessel was designed to reduce mechanical stresses in the walls during B T ramp phase of a shot. Therefore modified device - TUMAN-3M is able to produce higher B T and I p , up to 2 T and 0.2 MA respectively. During first experimental run device was operated in Ohmic Regime. In these experiments the possibility to achieve Ohmic H-mode was studied. The study of the parametric dependencies of the energy confinement time in both OH and Ohmic H-mode was performed. In Ohmic H-mode strong dependencies of τ E on plasma current and on input power and weak dependence on density were found. Energy confinement time in TUMAN-3/TUMAN-3M Ohmic H-mode has revealed good agreement with JET/DIII-D/ASDEX scaling for ELM-free H-mode, resulting in very long τ E at the high plasma current discharges. (author)

  6. High performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry for V and Ni quantification as tetrapyrroles

    Science.gov (United States)

    Duyck, Christiane Béatrice; Saint'Pierre, Tatiana Dillenburg; Miekeley, Norbert; da Fonseca, Teresa Cristina Oliveira; Szatmari, Peter

    2011-05-01

    A method was developed for the determination of V and Ni as tetrapyrroles by High Performance Liquid Chromatography hyphenated to Inductively Coupled Plasma Mass Spectrometry (HPLC-ICP-MS) using reversed phase and elution gradient. Chlorinated solvents and tetrahydrofuran were investigated as regard to separation time and ICP-MS detection efficiencies. The final elution gradient program started from pure methanol to a mixture of 20:80 (v/v) chloroform:methanol. External quantification of V and Ni with inorganic standards by flow injection ICP-MS, used online with HPLC, resulted in 95% of recoveries. The Limits of Detection for V during methanol elution and for Ni during the 20% chloroform gradient elution were evaluated by their minimum detectable concentrations, which were, respectively, 5 μg L - 1 and 8 μg L - 1 . The methodology was applied to polar and resin fractions separated from a Brazilian crude oil and a sediment extract from an oil-polluted area in the Guanabara Bay, Rio de Janeiro, Brazil. Vanadium as tetrapyrroles represented the totality of V content in the polar fraction, whereas Ni was in different polar forms in the resin and sediment extract.

  7. Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction.

    Science.gov (United States)

    Zhou, Jun; Sun, Jiang Bing; Wang, Qiao Feng

    2018-01-01

    A novel improved preconcentration method known as synergistic cloud point extraction was established for isoquercitrin preconcentration and determination in rat plasma prior to its determination by high performance liquid chromatography. Synergistic cloud point extraction greatly simplified isoquercitrin extraction and detection. This method was accomplished at room temperature (about 22°C) in 1min with the nonionic surfactant Tergitol TMN-6 as the extractant, n-octanol as cloud point revulsant and synergic reagent. Parameters that affect the synergistic cloud point extraction processes, such as the concentrations of Tergitol TMN-6, volume of n-octanol, sample pH, salt content and extraction time were investigated and optimized. Under the optimum conditions, the calibration curve for the analyte was linear in the range from 5 to 500ngmL -1 with the correlation coefficients greater than 0.9996. Meanwhile, limit of detection (S/N=3) was less than 1.6ngmL -1 and limit of quantification (S/N=10) was less than 5ngmL -1 . It demonstrated that the method can be successfully applied to the pharmacokinetic investigation of isoquercitrin. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Fingerprinting of complex mixtures with the use of high performance liquid chromatography, inductively coupled plasma atomic emission spectroscopy and chemometrics

    International Nuclear Information System (INIS)

    Ni Yongnian; Peng Yunyan; Kokot, Serge

    2008-01-01

    The molecular and metal profile fingerprints were obtained from a complex substance, Atractylis chinensis DC-a traditional Chinese medicine (TCM), with the use of the high performance liquid chromatography (HPLC) and inductively coupled plasma atomic emission spectroscopy (ICP-AES) techniques. This substance was used in this work as an example of a complex biological material, which has found application as a TCM. Such TCM samples are traditionally processed by the Bran, Cut, Fried and Swill methods, and were collected from five provinces in China. The data matrices obtained from the two types of analysis produced two principal component biplots, which showed that the HPLC fingerprint data were discriminated on the basis of the methods for processing the raw TCM, while the metal analysis grouped according to the geographical origin. When the two data matrices were combined into a one two-way matrix, the resulting biplot showed a clear separation on the basis of the HPLC fingerprints. Importantly, within each different grouping the objects separated according to their geographical origin, and they ranked approximately in the same order in each group. This result suggested that by using such an approach, it is possible to derive improved characterisation of the complex TCM materials on the basis of the two kinds of analytical data. In addition, two supervised pattern recognition methods, K-nearest neighbors (KNNs) method, and linear discriminant analysis (LDA), were successfully applied to the individual data matrices-thus, supporting the PCA approach

  9. [Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].

    Science.gov (United States)

    Feng, Chengya; Gao, Jieying; Zhen, Qianna; Fan, Zimian; Zhu, Mingsong; Yang, Xiangchun; Ding, Min

    2013-06-01

    A high performance liquid chromatography-ultraviolet/fluorescence detection (HPLC-UV/FLD) with on-column derivatization was established to simultaneously determine tryptophan (Trp), kynurenine (Kyn), 5-hydroxyindole acetic acid (5-Hiaa) and kynurenic acid (Kyna). A Hypersil C-18 column (250 mm x 4.0 mm, 5 microm) was used for the analysis at 30 degrees C. The separation was carried out with the mobile phase consisting of 250 mmol/L zinc acetate (pH 5.5) and acetonitrile (95: 5, v/v) at a flow rate of 0.8 mL/min using 3-nitrotyrosine as internal standard (IS). The excitation (Ex) and emission (Em) wavelengths were set at 278 nm (lambda(ex))/343 nm (lambda(em)) for 5-Hiaa and 244 nm (lambda(ex))/400 nm (lambda(em)) for Kyna, while the wavelengths of ultraviolet detection were set at 360 nm for Kyn and IS, 302 nm for Trp. The recoveries were in the range of 91.62% to 114.17%. The linearities were from 2.50 micromol/L to 320.00 micromol/L for Trp, 0.32 micromol/L to 15.36 micromol/L for Kyn, 3.27 nmol/L to 104.60 nmol/L for 5-Hiaa, and 14.00 nmol/L to 464.80 nmol/L for Kyna. The detection limits were 0.078 micromol/L, 0.056 micromol/L, 0.690 nmol/L and 1.290 nmol/L for Trp, Kyn, 5-Hiaa, and Kyna, respectively. Thirty plasma samples of normal pregnant women and 28 plasma samples of healthy controls were tested, and the results exhibited that the concentrations of Trp, Kyn and Kyna in the plasma of the normal pregnant women were significantly different from those of the control group (all P < 0.01). The method is simple and sensitive with good reproducibility, and it is suitable for clinical measurements.

  10. Ubiquity of non-diffusive momentum transport in JET H-modes

    NARCIS (Netherlands)

    Weisen, H.; Camenen, Y.; Salmi, A.; Versloot, T. W.; de Vries, P. C.; Maslov, M.; Tala, T.; Beurskens, M.; Giroud, C.; JET-EFDA Contributors,

    2012-01-01

    A broad survey of the experimental database of neutral beam heated baseline H-modes and hybrid scenarios in the JET tokamak has established the ubiquity of non-diffusive momentum transport mechanisms in rotating plasmas. As a result of their presence, the normalized angular frequency gradient R

  11. Radiative type-III ELMy H-mode in all-tungsten ASDEX Upgrade

    NARCIS (Netherlands)

    Rapp, J.; Kallenbach, A.; Neu, R.; Eich, T.; Fischer, R.; Herrmann, A.; Potzel, S.; van Rooij, G. J.; Zielinski, J. J.; ASDEX Upgrade team,

    2012-01-01

    The type-III ELMy H-mode might be the solution for an integrated ITER operation scenario fulfilling the fusion power amplification factor (output fusion power to input heating power) of Q = 10 with simultaneous acceptable steady-state and transient power loads to the plasma-facing components. This

  12. H-mode and confinement studies in ASDEX Upgrade

    International Nuclear Information System (INIS)

    Suttrop, W.; Ryter, F.; Mertens, V.; Gruber, O.; Murmann, H.; Salzmann, H.; Schweinzer, J.

    2001-01-01

    H-mode operational boundaries and H-mode confinement are investigated on ASDEX Upgrade. The local edge parameter threshold for H-mode holds independent of divertor geometry and changes little with ion mass. The deviation of the H-mode power threshold at densities near the Greenwald limit can be understood as a consequence of a confinement deterioration, caused by 'stiff' temperature profiles and lack of core density gradients in gas puff fuelled discharges. Ion and electron temperature profiles can be described by a lower limit of gradient length L T =T/T'. (author)

  13. Determination of technetium-99 in soil samples by high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Muto, Toshio; Shimokawa, Toshinari

    1997-01-01

    A new powerful analytical technique viz. high performance liquid chromatography(HPLC) coupled to inductively coupled plasma mass spectrometry(HPLC/ICP-MS) has been applied to the determination of technetium-99( 99 Tc) in soils as a typical environmental sample. Technetium was enriched in a solution from incinerated soil samples by leaching in HNO 3 and passed through 'TEVA resin' column. The solution was injected into HPLC/ICP-MS system to eliminate the interfering elements (i.e. Ru and Mo) and to determine the 99 Tc concentration at the same time. The concentrations of 99 Tc in the incinerated soils were found to be 0.49Bq/kg(0.77ng/kg)-1.4Bq/kg(2.2ng/kg) with the determination limit of 0.02Bq/kg(0.03ng/kg(0.03ppt)). The results indicate the following findings; 1) the determination of 99 Tc by ICP-MS after strict elimination of the interfering elements by HPLC brings about the improvement in their reliability; 2) the detection limits identified are much lower compared with those by conventional ICP-MS methods because of the concentration of 99 Tc to smaller volume, which is due to only 100μl of samples could be measured by HPLC/ICP-MS system; 3) sample preparation could be simplified because of strict elimination of the interfering elements by HPLC. This research showed that HPLC/ICP-MS system is very effective to determine 99 Tc in environmental samples. (author)

  14. Ultra-Sensitive Elemental Analysis Using Plasmas 5.Speciation of Arsenic Compounds in Biological Samples by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry System

    Science.gov (United States)

    Kaise, Toshikazu

    Arsenic originating from the lithosphere is widely distributed in the environment. Many arsenicals in the environment are in organic and methylated species. These arsenic compounds in drinking water or food products of marine origin are absorbed in human digestive tracts, metabolized in the human body, and excreted viatheurine. Because arsenic shows varying biological a spects depending on its chemical species, the biological characteristics of arsenic must be determined. It is thought that some metabolic pathways for arsenic and some arsenic circulation exist in aqueous ecosystems. In this paper, the current status of the speciation analysis of arsenic by HPLC/ICP-MS (High Performance Liquid Chromatography-Inductively Coupled Plasma Mass spectrometry) in environmental and biological samples is summarized using recent data.

  15. Origin of the various beta dependences of ELMy H-mode confinement properties

    International Nuclear Information System (INIS)

    Takizuka, T; Urano, H; Takenaga, H; Oyama, N

    2006-01-01

    Dependence of the energy confinement in ELMy H-mode tokamak on the beta has been investigated for a long time, but a common conclusion has not been obtained so far. Recent non-dimensional transport experiments in JT-60U demonstrated clearly the beta degradation. A database for JT-60U ELMy H-mode confinement was assembled. Analysis of this database is carried out, and the strong beta degradation consistent with the above experiments is confirmed. Two subsets of ASDEX Upgrade and JET data in the ITPA H-mode confinement database are analysed to find the origin of the various beta dependences. The shaping of the plasma cross section, as well as the fuelling condition, affects the confinement performance. The beta dependence is not identical for different devices and conditions. The shaping effect, as well as the fuelling effect, is a possible candidate for causing the variation of beta dependence

  16. Determination of phenolic derivatives of antipyrine in plasma with solid-phase extraction and high-performance liquid chromatography-atmospheric-pressure chemical ionization mass spectrometry

    NARCIS (Netherlands)

    Coolen, S.A.J.; Ligor, T.; Lieshout, van H.P.M.; Huf, F.A.

    1999-01-01

    This manuscript describes a method to determine antipyrine and its phenolic derivatives in plasma by reversed-phase high-performance liquid chromatography–mass spectrometry (RP-HPLC–MS). The sample pretreatment consisted of a C18 solid-phase extraction (SPE), to remove the salts and proteins. The

  17. Analysis of 6-mercaptopurine in human plasma with a high-performance liquid chromatographic method including post-column derivatization and fluorimetric detection

    NARCIS (Netherlands)

    Jonkers, R. E.; Oosterhuis, B.; ten Berge, R. J.; van Boxtel, C. J.

    1982-01-01

    A relatively simple assay with improved reliability and sensitivity for measuring levels of 6-mercaptopurine in human plasma is presented. After extraction of the compound and the added internal standard with phenyl mercury acetate, samples were separated by ion-pair reversed-phase high-performance

  18. [Qualitative and quantitative analysis of amygdalin and its metabolite prunasin in plasma by ultra-high performance liquid chromatography-tandem quadrupole time of flight mass spectrometry and ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry].

    Science.gov (United States)

    Gao, Meng; Wang, Yuesheng; Wei, Huizhen; Ouyang, Hui; He, Mingzhen; Zeng, Lianqing; Shen, Fengyun; Guo, Qiang; Rao, Yi

    2014-06-01

    A method was developed for the determination of amygdalin and its metabolite prunasin in rat plasma after intragastric administration of Maxing shigan decoction. The analytes were identified by ultra-high performance liquid chromatography-tandem quadrupole time of flight mass spectrometry and quantitatively determined by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry. After purified by liquid-liquid extraction, the qualitative analysis of amygdalin and prunasin in the plasma sample was performed on a Shim-pack XR-ODS III HPLC column (75 mm x 2.0 mm, 1.6 microm), using acetonitrile-0.1% (v/v) formic acid aqueous solution. The detection was performed on a Triple TOF 5600 quadrupole time of flight mass spectrometer. The quantitative analysis of amygdalin and prunasin in the plasma sample was performed by separation on an Agilent C18 HPLC column (50 mm x 2.1 mm, 1.7 microm), using acetonitrile-0.1% (v/v) formic acid aqueous solution. The detection was performed on an AB Q-TRAP 4500 triple quadrupole mass spectrometer utilizing electrospray ionization (ESI) interface operated in negative ion mode and multiple-reaction monitoring (MRM) mode. The qualitative analysis results showed that amygdalin and its metabolite prunasin were detected in the plasma sample. The quantitative analysis results showed that the linear range of amygdalin was 1.05-4 200 ng/mL with the correlation coefficient of 0.999 0 and the linear range of prunasin was 1.25-2 490 ng/mL with the correlation coefficient of 0.997 0. The method had a good precision with the relative standard deviations (RSDs) lower than 9.20% and the overall recoveries varied from 82.33% to 95.25%. The limits of detection (LODs) of amygdalin and prunasin were 0.50 ng/mL. With good reproducibility, the method is simple, fast and effective for the qualitative and quantitative analysis of the amygdalin and prunasin in plasma sample of rats which were administered by Maxing shigan decoction.

  19. The H-mode power threshold in JET

    Energy Technology Data Exchange (ETDEWEB)

    Start, D F.H.; Bhatnagar, V P; Campbell, D J; Cordey, J G; Esch, H P.L. de; Gormezano, C; Hawkes, N; Horton, L; Jones, T T.C.; Lomas, P J; Lowry, C; Righi, E; Rimini, F G; Saibene, G; Sartori, R; Sips, G; Stork, D; Thomas, P; Thomsen, K; Tubbing, B J.D.; Von Hellermann, M; Ward, D J [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking

    1994-07-01

    New H-mode threshold data over a range of toroidal field and density values have been obtained from the present campaign. The scaling with n{sub e} B{sub t} is almost identical with that of the 91/92 period for the same discharge conditions. The scaling with toroidal field alone gives somewhat higher thresholds than the older data. The 1991/2 database shows a scaling of P{sub th} (power threshold) with n{sub e} B{sub t} which is approximately linear and agrees well with that observed on other tokamaks. For NBI and carbon target tiles the threshold power is a factor of two higher with the ion {Nu}B drift away from the target compared with the value found with the drift towards the target. The combination of ICRH and beryllium tiles appears to be beneficial for reducing P{sub th}. The power threshold is largely insensitive to plasma current, X-point height and distance between the last closed flux surface and the limiter, at least for values greater than 2 cm. (authors). 3 refs., 6 figs.

  20. Scaling studies of the H-mode pedestal

    International Nuclear Information System (INIS)

    Groebner, R.J.; Osborne, T.H.

    1998-01-01

    The structure and scaling of the H-mode pedestal are examined for discharges in the DIII-D tokamak. For typical conditions, the pedestal values of the ion and electron temperatures T i and T e are comparable. Measurements of main ion and C 6+ profiles indicate that the ion pressure gradient in the barrier is 50%--100% of the electron pressure gradient for deuterium plasmas. The magnitude of the pressure gradient in the barrier often exceeds the predictions of infinite-n ballooning mode theory by a factor of two. Moreover, via the bootstrap current, the finite pressure gradient acts to entirely remove ballooning stability limits for typical discharges. For a large dataset, the width of the pressure barrier δ is best described by the dimensionless scaling δ/R ∝ (β pol ped ) 0.4 where (β pol ped ) is the pedestal value of poloidal beta and R is the major radius. Scalings based on the poloidal ion gyroradius or the edge density gradient do not adequately describe overall trends in the data set and the propagation of the pressure barrier observed between edge-localized modes. The width of the T i barrier is quite variable and is not a good measure of the width of the pressure barrier

  1. Comparison of turbulence measurements from DIII-D low-mode and high-performance plasmas to turbulence simulations and models

    International Nuclear Information System (INIS)

    Rhodes, T.L.; Leboeuf, J.-N.; Sydora, R.D.; Groebner, R.J.; Doyle, E.J.; McKee, G.R.; Peebles, W.A.; Rettig, C.L.; Zeng, L.; Wang, G.

    2002-01-01

    Measured turbulence characteristics (correlation lengths, spectra, etc.) in low-confinement (L-mode) and high-performance plasmas in the DIII-D tokamak [Luxon et al., Proceedings Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. I, p. 159] show many similarities with the characteristics determined from turbulence simulations. Radial correlation lengths Δr of density fluctuations from L-mode discharges are found to be numerically similar to the ion poloidal gyroradius ρ θ,s , or 5-10 times the ion gyroradius ρ s over the radial region 0.2 θ,s or 5-10 times ρ s , an experiment was performed which modified ρ θs while keeping other plasma parameters approximately fixed. It was found that the experimental Δr did not scale as ρ θ,s , which was similar to low-resolution UCAN simulations. Finally, both experimental measurements and gyrokinetic simulations indicate a significant reduction in the radial correlation length from high-performance quiescent double barrier discharges, as compared to normal L-mode, consistent with reduced transport in these high-performance plasmas

  2. A quantitative assay of cortisol in human plasma by high performance liquid chromatography using a selective chemically bonded stationary phase

    NARCIS (Netherlands)

    van den Berg, J.H.M.; Mol, C.R.; Deelder, R.S.; Thijssen, J.H.H.

    1977-01-01

    The extraction and subsequent liquid chromatographic analysis of human plasma samples for cortisol is described. Extraction and chromatography are optimized, resulting in a recovery for cortisol of 96% and a detection limit of 1 microgram cortisol in 100 ml plasma. The application of two chemically

  3. QUANTITATIVE-DETERMINATION OF THE DOPAMINE AGONIST LISURIDE IN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

    NARCIS (Netherlands)

    WOLTHERS, BG; KAMERBEEK, WDJV; VANBEUSEKOM, CM; ELSHOF, F; BUITENHUIS, AWD; BRUNT, EPR; LAKKE, JPWF

    1993-01-01

    An HPLC method for the determination of lisuride hydrogen maleate in plasma is described. After addition of ergotamine tartrate as internal standard, plasma is extracted with diethyl ether. Following evaporation of the solvent and redissolving in methanol the extract is injected on a silica HPLC

  4. Analysis of native human plasma proteins and haemoglobin for the presence of bityrosine by high-performance liquid chromatography

    DEFF Research Database (Denmark)

    Daneshvar, B; Frandsen, H; Dragsted, L O

    1997-01-01

    fluorescent substance, bityrosine. High-performance liquid chromatography (HPLC) analysis of acid hydrolyzed serum albumin after oxidation with peroxidase/H2O2 or with Cu++/H2O2 showed that bityrosine had been formed whereas oxidation of this protein with Fe(III)/ascorbate did not result in the formation...

  5. Operational limits of high density H-modes in ASDEX Upgrade

    International Nuclear Information System (INIS)

    Mertens, V.; Borrass, K.; Kaufmann, M.; Lang, P.T.; Lang, R.; Mueller, H.W.; Neuhauser, J.; Schneider, R.; Schweinzer, J.; Suttrop, W.

    2001-01-01

    Systematic investigations of H-mode density limit (H→L-mode back transition) plasmas with gas fuelling and alternatively with additional pellet injection from the magnetic high-field-side HFS are being performed in the new closed divertor configuration DV-II. The resulting database covering a wide range of the externally controllable plasma parameters I p , B t and P heat confirms that the H-mode threshold power exceeds the generally accepted prediction P L→H heat ∝B-bar t dramatically when one approaches Greenwald densities. Additionally, in contrast to the Greenwald scaling a moderate B t -dependence of the H-mode density limit is found. The limit is observed to coincide with divertor detachment and a strong increase of the edge thermal transport, which has, however, no detrimental effect on global τ E . The pellet injection scheme from the magnetic high-field-side HFS, developed recently on ASDEX Upgrade, leads to fast particle drifts which are, contrary to the standard injection from the low-field-side, directed into the plasma core. This improves markedly the pellet particle fuelling efficiency. The responsible physical mechanism, the diamagnetic particle drift of the pellet ablatant was successfully verified recently. Other increased particle losses on respectively different time scales after the ablation process, however, still persist. Generally, a clear gain in achievable density and plasma stored energy is achieved with stationary HFS pellet injection compared to gas-puffing. (author)

  6. Proceedings of JSPS-CAS Core University Program seminar on production and steady state confinement of high performance plasmas in magnetic confinement systems

    International Nuclear Information System (INIS)

    Wan Baonian; Toi, Kazuo

    2005-09-01

    The JSPS-CAS Core University Program (CUP) seminar on 'Production and steady-state confinement of high performance plasmas in magnetic confinement systems' was held from 27 July to 29 July 2005 in Institute of Plasma Physics, the Chinese Academy of Sciences, Hefei, China. This seminar was organized in the framework of CUP in the field of plasma and nuclear fusion. About 50 persons including 20 Japanese attendees attended this seminar. Long time sustainment of high confinement and high beta plasmas is crucial for realization of an advanced nuclear fusion reactor. This seminar was motivated to summarize the results of CUP obtained in four years activities of CUP, and to extract crucial issues to be resolved near future, which must drive near and mid- term collaborations in the framework of CUP. The 32 of presented papers are indexed individually. (J.P.N.)

  7. Simple measurement of isepamicin, a new aminoglycoside antibiotic, in guinea pig and human plasma, using high-performance liquid chromatography with ultraviolet detection

    International Nuclear Information System (INIS)

    Dionisotti, S.; Bamonte, F.; Scaglione, F.; Ongini, E.

    1991-01-01

    Isepamicin, the 1-N-(S-alpha-hydroxy-beta-aminopropionyl) derivative of gentamicin B, is a new aminoglycoside antibiotic, which not only has most of the properties of amikacin but also is effective against several amikacin-resistant strains of bacteria. The drug was assayed in guinea-pig and human plasma with a high-performance liquid chromatographic procedure using precolumn derivatization with 1-fluoro-2,4-dinitrobenzene and ultraviolet detection. Linearity was established over the range 0.5-40 micrograms/ml using 50 microliters of plasma. Accuracy has a mean relative error of less than 3% and precision a mean coefficient of variation of 5%. Isepamicin was determined without interference from plasma constituents or other drugs commonly prescribed during aminoglycoside therapy. This procedure correlates well with radioimmunoassay and can be used either in experimental studies or therapeutic monitoring of plasma levels

  8. Analysis of the H-mode density limit in the ASDEX upgrade tokamak using bolometry

    Energy Technology Data Exchange (ETDEWEB)

    Bernert, Matthias

    2013-10-23

    The high confinement mode (H-mode) is the operational scenario foreseen for ITER, DEMO and future fusion power plants. At high densities, which are favourable in order to maximize the fusion power, a back transition from the H-mode to the low confinement mode (L-mode) is observed. This H-mode density limit (HDL) occurs at densities on the order of, but below, the Greenwald density. In this thesis, the HDL is revisited in the fully tungsten walled ASDEX Upgrade tokamak (AUG). In AUG discharges, four distinct operational phases were identified in the approach towards the HDL. First, there is a stable H-mode, where the plasma density increases at steady confinement, followed by a degrading H-mode, where the core electron density is fixed and the confinement, expressed as the energy confinement time, reduces. In the third phase, the breakdown of the H-mode and transition to the L-mode, the overall electron density is fixed and the confinement decreases further, leading, finally, to an L-mode, where the density increases again at a steady confinement at typical L-mode values until the disruptive Greenwald limit is reached. These four phases are reproducible, quasi-stable plasma regimes and provide a framework in which the HDL can be further analysed. Radiation losses and several other mechanisms, that were proposed as explanations for the HDL, are ruled out for the current set of AUG experiments with tungsten walls. In addition, a threshold of the radial electric field or of the power flux into the divertor appears to be responsible for the final transition back to L-mode, however, it does not determine the onset of the HDL. The observation of the four phases is explained by the combination of two mechanisms: a fueling limit due to an outward shift of the ionization profile and an additional energy loss channel, which decreases the confinement. The latter is most likely created by an increased radial convective transport at the edge of the plasma. It is shown that the

  9. Analysis of the H-mode density limit in the ASDEX upgrade tokamak using bolometry

    International Nuclear Information System (INIS)

    Bernert, Matthias

    2013-01-01

    The high confinement mode (H-mode) is the operational scenario foreseen for ITER, DEMO and future fusion power plants. At high densities, which are favourable in order to maximize the fusion power, a back transition from the H-mode to the low confinement mode (L-mode) is observed. This H-mode density limit (HDL) occurs at densities on the order of, but below, the Greenwald density. In this thesis, the HDL is revisited in the fully tungsten walled ASDEX Upgrade tokamak (AUG). In AUG discharges, four distinct operational phases were identified in the approach towards the HDL. First, there is a stable H-mode, where the plasma density increases at steady confinement, followed by a degrading H-mode, where the core electron density is fixed and the confinement, expressed as the energy confinement time, reduces. In the third phase, the breakdown of the H-mode and transition to the L-mode, the overall electron density is fixed and the confinement decreases further, leading, finally, to an L-mode, where the density increases again at a steady confinement at typical L-mode values until the disruptive Greenwald limit is reached. These four phases are reproducible, quasi-stable plasma regimes and provide a framework in which the HDL can be further analysed. Radiation losses and several other mechanisms, that were proposed as explanations for the HDL, are ruled out for the current set of AUG experiments with tungsten walls. In addition, a threshold of the radial electric field or of the power flux into the divertor appears to be responsible for the final transition back to L-mode, however, it does not determine the onset of the HDL. The observation of the four phases is explained by the combination of two mechanisms: a fueling limit due to an outward shift of the ionization profile and an additional energy loss channel, which decreases the confinement. The latter is most likely created by an increased radial convective transport at the edge of the plasma. It is shown that the

  10. H-mode regimes and observators of central toroidal rotation in Alcator C-Mod

    International Nuclear Information System (INIS)

    Greenwald, M.; Rice, J.; Boivin, R.

    1999-01-01

    The Enhanced D α or EDA H-mode regime in Alcator C-Mod has been investigated and compared in detail to ELM-free plasmas. (In this paper, ELM-free will refer to discharges with no type I ELMs and with no sign of EDA, though technically, most EDA plasmas are ELM-free as well.) EDA discharges have only slightly lower energy confinement than comparable ELM-free ones, but show markedly reduced impurity confinement. Thus EDA discharges do not accumulate impurities and typically have a lower fraction of radiated power. EDA plasmas are seen to be more likely at low plasma current (q > 3.7 - 4), for moderate plasma shaping (0.35 - 0.55), and for high neutral pressures. No obvious trends were observed with input power or pressure (β). In both H-mode regimes, and in ICRF heated L-modes, central impurity toroidal rotation has been deduced, from the Doppler shifts of argon x-ray lines. Rotation velocities up to 1.3 x 10 5 m/s in the co-current direction have been observed in H-mode discharges that had no direct momentum input. There is a strong correlation between the increase in the central impurity rotation velocity and the increase in the plasma stored energy, induced by ICRF heating. In otherwise similar discharges with the same stored energy increase, plasmas with lower current rotate faster. The ion pressure gradient is an unimportant contributor to the central impurity rotation and the presence of a substantial core radial electric field is inferred during the ICRF pulse. An inward shift of ions induced by ICRF waves could give rise to a non-ambipolar electric field in the plasma core. Comparisons with a neo-classical ion orbit shift model show good agreement with the observations, both in magnitude, and in the scaling with plasma current. (author)

  11. The role of MHD instabilities in the improved H-mode scenario

    International Nuclear Information System (INIS)

    Flaws, Asher

    2009-01-01

    Recently a regime of tokamak operation has been discovered, dubbed the improved H-mode scenario, which simultaneously achieves increased energy confinement and stability with respect to standard H-mode discharges. It has been suggested that magnetohydrodynamic (MHD) instabilities play some role in establishing this regime. In this thesis MHD instabilities were identified, characterised, and catalogued into a database of improved H-mode discharges in order to statistically examine their behaviour. The onset conditions of MHD instabilities were compared to existing models based on previous H-mode studies. Slight differences were found, most notably a reduced β N onset threshold for the frequently interrupted regime for neoclassical tearing modes (NTM). This reduced threshold is due to the relatively low magnetic shear of the improved H-mode regime. This study also provided a first-time estimate for the seed island size of spontaneous onset NTMs, a phenomenon characteristic of the improved H-mode scenario. Energy confinement investigations found that, although the NTM impact on confinement follows the same model applicable to other operating regimes, the improved H-mode regime acts to mitigate the impact of NTMs by limiting the saturated island sizes for NTMs with toroidal mode number n ≥ 2. Surprisingly, although a significant loss in energy confinement is observed during the sawtooth envelope, it has been found that discharges containing fishbones and low frequency sawteeth achieve higher energy confinement than those without. This suggests that fishbone and sawtooth reconnection may indeed play a role in establishing the high confinement regime. It was found that the time evolution of the central magnetic shear consistently locks in the presence of sawtooth and fishbone reconnection. Presumably this is due to the periodic redistribution of the central plasma current, an effect which is believed to help establish and maintain the characteristic current profile

  12. The role of MHD instabilities in the improved H-mode scenario

    Energy Technology Data Exchange (ETDEWEB)

    Flaws, Asher

    2009-02-16

    Recently a regime of tokamak operation has been discovered, dubbed the improved H-mode scenario, which simultaneously achieves increased energy confinement and stability with respect to standard H-mode discharges. It has been suggested that magnetohydrodynamic (MHD) instabilities play some role in establishing this regime. In this thesis MHD instabilities were identified, characterised, and catalogued into a database of improved H-mode discharges in order to statistically examine their behaviour. The onset conditions of MHD instabilities were compared to existing models based on previous H-mode studies. Slight differences were found, most notably a reduced {beta}{sub N} onset threshold for the frequently interrupted regime for neoclassical tearing modes (NTM). This reduced threshold is due to the relatively low magnetic shear of the improved H-mode regime. This study also provided a first-time estimate for the seed island size of spontaneous onset NTMs, a phenomenon characteristic of the improved H-mode scenario. Energy confinement investigations found that, although the NTM impact on confinement follows the same model applicable to other operating regimes, the improved H-mode regime acts to mitigate the impact of NTMs by limiting the saturated island sizes for NTMs with toroidal mode number n {>=} 2. Surprisingly, although a significant loss in energy confinement is observed during the sawtooth envelope, it has been found that discharges containing fishbones and low frequency sawteeth achieve higher energy confinement than those without. This suggests that fishbone and sawtooth reconnection may indeed play a role in establishing the high confinement regime. It was found that the time evolution of the central magnetic shear consistently locks in the presence of sawtooth and fishbone reconnection. Presumably this is due to the periodic redistribution of the central plasma current, an effect which is believed to help establish and maintain the characteristic current

  13. Study on H-mode access at low density with lower hybrid current drive and lithium-wall coatings on the EAST superconducting tokamak

    DEFF Research Database (Denmark)

    Xu, G.S.; Wan, B.N.; Li, J.G.

    2011-01-01

    The first high-confinement mode (H-mode) with type-III edge localized modes at an H factor of HIPB98(y,2) ~ 1 has been obtained with about 1 MW lower hybrid wave power on the EAST superconducting tokamak. The first H-mode plasma appeared after wall conditioning by lithium (Li) evaporation before ...

  14. High-performance liquid chromatographic determination of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone in plasma.

    Science.gov (United States)

    Rodgers, A H; Subramanian, S; Morgan, L R

    1995-08-18

    An analytical method has been developed for the determination of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (I, trade name A-007) in plasma. Plasma samples are primed with the internal standard, 2,2'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (II), deproteinized with acetonitrile, centrifuged and filtered prior to assay. The components are then separated on a reversed-phase column with retention times of 4.4 and 6.0 min for I and II, respectively. Ultraviolet detection at 365 nm was employed and little interference with the analyte or the internal standard was noted from other plasma components. This method has been applied to the plasma of rats and monkeys doses for pharmacokinetic and toxicity studies.

  15. Demonstration of high-performance p-type tin oxide thin-film transistors using argon-plasma surface treatments

    Science.gov (United States)

    Bae, Sang-Dae; Kwon, Soo-Hun; Jeong, Hwan-Seok; Kwon, Hyuck-In

    2017-07-01

    In this work, we investigated the effects of low-temperature argon (Ar)-plasma surface treatments on the physical and chemical structures of p-type tin oxide thin-films and the electrical performance of p-type tin oxide thin-film transistors (TFTs). From the x-ray photoelectron spectroscopy measurement, we found that SnO was the dominant phase in the deposited tin oxide thin-film, and the Ar-plasma treatment partially transformed the tin oxide phase from SnO to SnO2 by oxidation. The resistivity of the tin oxide thin-film increased with the plasma-treatment time because of the reduced hole concentration. In addition, the root-mean-square roughness of the tin oxide thin-film decreased as the plasma-treatment time increased. The p-type oxide TFT with an Ar-plasma-treated tin oxide thin-film exhibited excellent electrical performance with a high current on-off ratio (5.2 × 106) and a low off-current (1.2 × 10-12 A), which demonstrates that the low-temperature Ar-plasma treatment is a simple and effective method for improving the electrical performance of p-type tin oxide TFTs.

  16. VH mode accessibility and global H-mode properties in previous and present JET configurations

    Energy Technology Data Exchange (ETDEWEB)

    Jones, T T.C.; Ali-Arshad, S; Bures, M; Christiansen, J P; Esch, H P.L. de; Fishpool, G; Jarvis, O N; Koenig, R; Lawson, K D; Lomas, P J; Marcus, F B; Sartori, R; Schunke, B; Smeulders, P; Stork, D; Taroni, A; Thomas, P R; Thomsen, K [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking

    1994-07-01

    In JET VH modes, there is a distinct confinement transition following the cessation of ELMs, observed in a wide variety of tokamak operating conditions, using both NBI and ICRF heating methods. Important factors which influence VH mode accessibility such as magnetic configuration and vessel conditions have been identified. The new JET pumped divertor configuration has much improved plasma shaping control and power and particle exhaust capability and should permit exploitation of plasmas with VH confinement properties over an even wider range of operating regimes, particularly at high plasma current; first H-modes have been obtained in the 1994 JET operating period and initial results are reported. (authors). 7 refs., 6 figs.

  17. Scaling of H-mode pedestal characteristics in DIII-D and C-Mod

    International Nuclear Information System (INIS)

    Granetz, R.S.; Boivin, R.L.; Osborne, T.H.

    1999-01-01

    Since the H-mode edge pedestal effectively sets the boundary conditions for energy transport throughout the core, a better understanding of the pedestal region is necessary in order to fully predict H-mode performance. Pedestal characteristics in the DIII-D and Alcator C-Mod tokamaks are described, and scalings of the pedestal width with various plasma parameters are shown. The pedestal width in both tokamaks varies in an inverse sense with plasma current, and is independent of toroidal field. Other similarities, as well as differences, are discussed. It is also found that the pedestal widths of the various physical quantities involved (T e , T i , n e , n i ) may be different. (author)

  18. Parameter dependences of the separatrix density in nitrogen seeded ASDEX Upgrade H-mode discharges

    Science.gov (United States)

    Kallenbach, A.; Sun, H. J.; Eich, T.; Carralero, D.; Hobirk, J.; Scarabosio, A.; Siccinio, M.; ASDEX Upgrade Team; EUROfusion MST1 Team

    2018-04-01

    The upstream separatrix electron density is an important interface parameter for core performance and divertor power exhaust. It has been measured in ASDEX Upgrade H-mode discharges by means of Thomson scattering using a self-consistent estimate of the upstream electron temperature under the assumption of Spitzer-Härm electron conduction. Its dependence on various plasma parameters has been tested for different plasma conditions in H-mode. The leading parameter determining n e,sep was found to be the neutral divertor pressure, which can be considered as an engineering parameter since it is determined mainly by the gas puff rate and the pumping speed. The experimentally found parameter dependence of n e,sep, which is dominated by the divertor neutral pressure, could be approximately reconciled by 2-point modelling.

  19. Characteristics of edge localized mode in JFT-2M H-mode

    International Nuclear Information System (INIS)

    Matsumoto, Hiroshi; Funahashi, Akimasa; Goldston, R.J.

    1989-03-01

    Characteristics of edge localized mode (ELM/ERP) during H-mode plasma of JFT-2M were investigated. It was found that ELM/ERP is mainly a density fluctuation phenomena in the edge, and electron temperature in the edge except just near the separatrix is not very much perturbed. Several experimental conditions to controll ELM/ERP are, plasma density, plasma ion species, heating power, and plasma current ramping. ELM/ERPs found in low density deuterium discharge are suppressed by raising the density. ELM/ERPs are pronounced in hydrogen plasma compared with deuterium plasma. ELM/ERPs seen in hydrogen plasma or in near marginal H-mode conditions are suppressed by increasing the heating power. ELM/ERPs are found to be suppressed by plasma current ramp down, whereas they are enhanced by current ramp up. MHD aspect of ELM/ERP was investigated. No clear MHD features of ELM/ERP were found. However, reversal of mode rotation seen imediately after ELM/ERP suggests the temporal return to L-mode during the ELM/ERP event. (author)

  20. High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring

    OpenAIRE

    Park, Youngja H.; Lee, Kichun; Soltow, Quinlyn A.; Strobel, Frederick H.; Brigham, Kenneth L.; Parker, Richard E.; Wilson, Mark E.; Sutliff, Roy L.; Mansfield, Keith G.; Wachtman, Lynn M.; Ziegler, Thomas R.; Jones, Dean P.

    2012-01-01

    High-performance metabolic profiling (HPMP) by Fourier-transform mass spectrometry coupled to liquid chromatography gives relative quantification of thousands of chemicals in biologic samples but has had little development for use in toxicology research. In principle, the approach could be useful to detect complex metabolic response patterns to toxicologic exposures and to detect unusual abundances or patterns of potentially toxic chemicals. As an initial study to develop these possible uses,...

  1. Progress in qualifying the edge physics of the H-mode regime in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Baker, D.R.; Boedo, J.A.

    2001-01-01

    Edge conditions in DIII-D are being quantified in order to provide insight into the physics of the H-mode regime. Electron temperature is not the key parameter that controls the L-H transition. Gradients of edge temperature and pressure are much more promising candidates for such parameters. The quality of H-mode confinement is strongly correlated with the height of the H-mode pedestal for the pressure. The gradient of the pressure appears to be controlled by MHD modes, in particular by kink-ballooning modes with finite mode number n. For a wide variety of discharges, the width of the barrier is well described with a relationship that is proportional to (β p ped ) 1/2 . An attractive regime of confinement has been discovered which provides steady-state operation with no ELMs, low impurity content and normal H-mode confinement. A coherent edge MHD-mode evidently provides adequate particle transport to control the plasma density and impurity content while permitting the pressure pedestal to remain almost identical to that observed in ELMing discharges. (author)

  2. CO2 Plasma-Treated TiO2 Film as an Effective Electron Transport Layer for High-Performance Planar Perovskite Solar Cells.

    Science.gov (United States)

    Wang, Kang; Zhao, Wenjing; Liu, Jia; Niu, Jinzhi; Liu, Yucheng; Ren, Xiaodong; Feng, Jiangshan; Liu, Zhike; Sun, Jie; Wang, Dapeng; Liu, Shengzhong Frank

    2017-10-04

    Perovskite solar cells (PSCs) have received great attention because of their excellent photovoltaic properties especially for the comparable efficiency to silicon solar cells. The electron transport layer (ETL) is regarded as a crucial medium in transporting electrons and blocking holes for PSCs. In this study, CO 2 plasma generated by plasma-enhanced chemical vapor deposition (PECVD) was introduced to modify the TiO 2 ETL. The results indicated that the CO 2 plasma-treated compact TiO 2 layer exhibited better surface hydrophilicity, higher conductivity, and lower bulk defect state density in comparison with the pristine TiO 2 film. The quality of the stoichiometric TiO 2 structure was improved, and the concentration of oxygen-deficiency-induced defect sites was reduced significantly after CO 2 plasma treatment for 90 s. The PSCs with the TiO 2 film treated by CO 2 plasma for 90 s exhibited simultaneously improved short-circuit current (J SC ) and fill factor. As a result, the PSC-based TiO 2 ETL with CO 2 plasma treatment affords a power conversion efficiency of 15.39%, outperforming that based on pristine TiO 2 (13.54%). These results indicate that the plasma treatment by the PECVD method is an effective approach to modify the ETL for high-performance planar PSCs.

  3. Influence of the wall material on the H-mode performance

    International Nuclear Information System (INIS)

    Itoh, K.; Itoh, S.

    1994-06-01

    Theory on the influence of the wall material on the level of the enhanced confinement in H-mode is discussed. When the high-Z material is employed as the wall, the reflection of the neutral particles causes the higher neutral particle density in the plasma. The increased neutral particles lead to the loss of the ion momentum, decrease the radial electric field and degrade the confinement improvement. (author)

  4. Quantitative determination of the dopamine agonist lisuride in plasma using high-performance liquid chromatography with fluorescence detection.

    Science.gov (United States)

    Wolthers, B G; Verhagen Kamerbeek, W D; van Beusekom, C M; Elshof, F; de Ruyter Buitenhuis, A W; Brunt, E P; Lakke, J P

    1993-12-08

    An HPLC method for the determination of lisuride hydrogen maleate in plasma is described. After addition of ergotamine tartrate as internal standard, plasma is extracted with diethyl ether. Following evaporation of the solvent and redissolving in methanol the extract is injected on a silica HPLC column and lisuride is monitored by fluorescence detection using an excitation wavelength of 322 nm and an emission wavelength of 405 nm. The method is sufficiently accurate and precise with a detection limit of 20 pg/ml lisuride in plasma. The usefulness of the method is demonstrated by measurements of lisuride levels after oral intake of a 0.6 mg dose of the drug by a healthy male volunteer, showing a peak level of 1266 pg/ml, 45 min after intake.

  5. Density fluctuation measurements via reflectometry on DIII-D during L- and H-mode operation

    International Nuclear Information System (INIS)

    Doyle, E.J.; Lehecka, T.; Luhmann, N.C. Jr.; Peebles, W.A.; Philipona, R.

    1990-01-01

    The unique ability of reflectometers to provide radial density fluctuation measurements with high spatial resolution (of the order of ≤ centimeters, is ideally suited to the study of the edge plasma modifications associated with H-mode operation. Consequently, attention has been focused on the study of these phenomena since an improved understanding of the physics of H-mode plasmas is essential if a predictive capability for machine performance is to be developed. In addition, DIII-D is ideally suited for such studies since it is a major device noted for its robust H-mode operation and excellent basic plasma profile diagnostic information. The reflectometer system normally used for fluctuation studies is an O-mode, homodyne, system utilizing 7 discrete channels spanning 15-75 GHz, with corresponding critical densities of 2.8x10 18 to 7x10 19 m -3 . The Gunn diode sources in this system are only narrowly tunable in frequency, so the critical densities are essentially fixed. An X-mode system, utilizing a frequency tunable BWO source, has also been used to obtain fluctuation data, and in particular, to 'fill in the gaps' between the discrete O-mode channels. (author) 12 refs., 5 figs

  6. Simultaneous determination of phenytoin, carbamazepine, and 10,11-carbamazepine epoxide in human plasma by high-performance liquid chromatography with ultraviolet detection.

    Science.gov (United States)

    Bhatti, M M; Hanson, G D; Schultz, L

    1998-03-01

    The Bioanalytical Chemistry Department at the Madison facility of Covance Laboratories, has developed and validated a simple and sensitive method for the simultaneous determination of phenytoin (PHT), carbamazepine (CBZ) and 10,11-carbamazepine epoxide (CBZ-E) in human plasma by high-performance liquid chromatography with 10,11 dihydrocarbamazepine as the internal standard. Acetonitrile was added to plasma samples containing PHT, CBZ and CBZ-E to precipitate the plasma proteins. After centrifugation, the acetonitrile supernatant was transferred to a clean tube and evaporated under N2. The dried sample extract was reconstituted in 0.4 ml of mobile phase and injected for analysis by high-performance liquid chromatography. Separation was achieved on a Spherisorb ODS2 analytical column with a mobile phase of 18:18:70 acetonitrile:methanol:potassium phosphate buffer. Detection was at 210 nm using an ultraviolet detector. The mean retention times of CBZ-E, PHT and CBZ were 5.8, 9.9 and 11.8 min, respectively. Peak height ratios were fit to a least squares linear regression algorithm with a 1/(concentration)2 weighting. The method produces acceptable linearity, precision and accuracy to a minimum concentration of 0.050 micrograms ml-1 in human plasma. It is also simple and convenient, with no observable matrix interferences.

  7. Proceeding of A3 foresight program seminar on critical physics issues specific to steady state sustainment of high-performance plasmas 2014

    International Nuclear Information System (INIS)

    Morita, Shigeru; Hu Liqun; Oh, Yeong-Kook

    2014-10-01

    The A3 Foresight Program titled by 'Critical Physics Issues Specific to Steady State Sustainment of High-Performance Plasmas', based on the scientific collaboration among China, Japan and Korea in the field of plasma physics, has been started from August 2012 under the auspice of the Japan Society for the Promotion of Science (JSPS, Japan), the National Research Foundation of Korea (NRF, Korea) and the National Natural Science Foundation of China (NSFC, China). The main purpose of this project is to enhance joint experiments on three Asian advanced fully superconducting fusion devices (EAST in China, LHD in Japan and KSTAR in Korea) and other magnetic confinement devices to several key physics issues on steady state sustainment of high-performance plasmas. The fourth seminar on the A3 collaboration, as the fifth meeting of A3 program, took place in Kagoshima, Japan, 23-26 June 2014, which was hosted by National Institute for Fusion Science, to discuss achievement during past two years and to summarize intermediate report. New collaborative research was also encouraged as well as participation of young scientists. The topics include steady state sustainment of magnetic configuration, edge and divertor plasma control and confinement of alpha particles. This issue is the collection of 41 papers presented at the entitled meeting. All the 41 of the presented papers are indexed individually. (J.P.N.)

  8. Quasistationary Plasma Predator-Prey System of Coupled Turbulence, Drive, and Sheared E ×B Flow During High Performance DIII-D Tokamak Discharges

    Science.gov (United States)

    Barada, K.; Rhodes, T. L.; Burrell, K. H.; Zeng, L.; Bardóczi, L.; Chen, Xi; Muscatello, C. M.; Peebles, W. A.

    2018-03-01

    A new, long-lived limit cycle oscillation (LCO) regime has been observed in the edge of near zero torque high performance DIII-D tokamak plasma discharges. These LCOs are localized and composed of density turbulence, gradient drives, and E ×B velocity shear damping (E and B are the local radial electric and total magnetic fields). Density turbulence sequentially acts as a predator (via turbulence transport) of profile gradients and a prey (via shear suppression) to the E ×B velocity shear. Reported here for the first time is a unique spatiotemporal variation of the local E ×B velocity, which is found to be essential for the existence of this system. The LCO system is quasistationary, existing from 3 to 12 plasma energy confinement times (˜30 - 900 LCO cycles) limited by hardware constraints. This plasma system appears to contribute strongly to the edge transport in these high performance and transient-free plasmas, as evident from oscillations in transport relevant edge parameters at LCO time scale.

  9. Determination of nifedipine in dog plasma by high-performance liquid chromatography with tandem mass spectrometric detection.

    Science.gov (United States)

    Pan, Xigui; Zhou, Shunchang; Fu, Qinqin; Hu, Xianming; Wu, Jianhong

    2014-07-01

    Nifedipine is a dihydropyridine calcium channel blocker used widely in the management of hypertension and other cardiovascular disorders. In this work, a simple, rapid and sensitive liquid chromatography/tandem mass spectrometry method was developed and validated to determine nifedipine in dog plasma using nimodipine as the internal standard. Chromatographic separation was carried out on a C₈ column. The mobile phase consisted of a mixture of acetonitrile, water and formic acid (60:40:0.2, v/v/v) at a flow rate of 0.5 mL/min. Detection was performed on a triple quadrupole tandem mass spectrometer in selected reaction monitoring mode via an atmospheric pressure chemical ionization source. The method has a lower limit of quantification of 0.20 ng/mL with consumption of plasma as low as 0.05 mL. The linear calibration curves were obtained in the concentration range of 0.20-50.0 ng/mL (r = 0.9948). The recoveries of the liquid extraction method were 74.5-84.1%. Intra-day and inter-day precisions were 4.1-8.8 and 6.7-7.4%, respectively. The quantification was not interfered with by other plasma components and the method was applied to determine nifedipine in plasma after a single oral administration of two controlled-release nifedipine tablets to beagle dogs. Copyright © 2013 John Wiley & Sons, Ltd.

  10. High performance solution-deposited amorphous indium gallium zinc oxide thin film transistors by oxygen plasma treatment

    KAUST Repository

    Nayak, Pradipta K.; Hedhili, Mohamed N.; Cha, Dong Kyu; Alshareef, Husam N.

    2012-01-01

    decrease in oxygen vacancy and residual hydrocarbon concentration in the a-IGZO films, as well as an improvement in the dielectric/channel interfacial roughness. As a result, the TFTs with O2-plasma treated a-IGZO channel layers showed three times higher

  11. Atomic layer deposition of ruthenium on plasma-treated vertically aligned carbon nanotubes for high-performance ultracapacitors.

    Science.gov (United States)

    Kim, Jun Woo; Kim, Byungwoo; Park, Suk Won; Kim, Woong; Shim, Joon Hyung

    2014-10-31

    It is challenging to realize a conformal metal coating by atomic layer deposition (ALD) because of the high surface energy of metals. In this study, ALD of ruthenium (Ru) on vertically aligned carbon nanotubes (CNTs) was carried out. To activate the surface of CNTs that lack surface functional groups essential for ALD, oxygen plasma was applied ex situ before ALD. X-ray photoelectron spectroscopy and Raman spectroscopy confirmed surface activation of CNTs by the plasma pretreatment. Transmission electron microscopy analysis with energy-dispersive x-ray spectroscopy composition mapping showed that ALD Ru grew conformally along CNTs walls. ALD Ru/CNTs were electrochemically oxidized to ruthenium oxide (RuOx) that can be a potentially useful candidate for use in the electrodes of ultracapacitors. Electrode performance of RuOx/CNTs was evaluated using cyclic voltammetry and galvanostatic charge-discharge measurements.

  12. A quantitative analysis of the effect of ELMs on H-mode thermal energy confinement in DIII-D

    International Nuclear Information System (INIS)

    Schissel, D.P.; Osborne, T.H.; Carlstrom, T.N.; Zohm, H.

    1992-06-01

    The desire to reach ignition in future tokamaks the energy confinement time critical parameter. The most promising enhanced (over L-mode) confinement regime is the H-mode, discovered on ASDEX with neutral beam heating, and then confirmed with various auxiliary heating sources on numerous machines. The knowledge of how H-mode τ E depends on different parameters is of chemical importance to the performance predictions for next generation devices. Inter-machine H-mode total and thermal energy confinement (τ th ) scalings, which are being utilized to predict ITER thermal energy confinement, have been created for discharges where the Edge Localized Mode (ELM) instability has not been present. Confinement scaling research hm concentrated on this ELM-free H-mode phase mostly owing to the difficulty of characterizing ELM behavior. To date, long pulse H-mode operation has only been achieved by utilizing ELMs to flush out unpurities and prevent radiative collapse of the discharge. Unfortunately, accompanying the ELMS is a decrease of the plasma stored energy due to the expulsion of particles near the edge of the discharge resulting in a reduction of the steep edge electron density gradient. In order to predict ITER's H-mode τ th in the presence of ELMS, an estimated 25% confinement degradation factor has been applied to the ELM-free predictions. Our work, summarized in this paper, indicates that this 25% reduction factor is too large and instead a value of approximately 15% would be more appropriate

  13. ROLE OF NEUTRALS IN CORE FUELING AND PEDESTAL STRUCTURE IN H-MODE DIII-D DISCHARGES

    International Nuclear Information System (INIS)

    WOLF, NS; PETRIE, TW; PORTER, GD; ROGNLIEN, TD; GROEBNER, RJ; MAKOWSKI, MA

    2002-01-01

    OAK A271 ROLE OF NEUTRALS IN CORE FUELING AND PEDESTAL STRUCTURE IN H-MODE DIII-D DISCHARGES. The 2-D fluid code UEDGE was used to analyze DIII-D experiments to determine the role of neutrals in core fueling, core impurities, and also the H-mode pedestal structure. The authors compared the effects of divertor closure on the fueling rate and impurity density of high-triangularity, H-mode plasmas. UEDGE simulations indicate that the decrease in both deuterium core fueling (∼ 15%-20%) and core carbon density (∼ 15%-30%) with the closed divertor compared to the open divertor configuration is due to greater divertor screening of neutrals. They also compared UEDGE results with a simple analytic model of the H-mode pedestal structure. The model predicts both the width and gradient of the transport barrier in n e as a function of the pedestal density. The more sophisticated UEDGE simulations of H-mode discharges corroborate the simple analytic model, which is consistent with the hypothesis that fueling processes play a role in H-mode transport barrier formation

  14. Characteristics of the First H-mode Discharges in NSTX

    International Nuclear Information System (INIS)

    Maingi, R.; Bell, M.G.; Bell, R.E.; Bush, C.E.; Fredrickson, E.D.; Gates, D.A.; Kaye, S.M.; Kugel, H.W.; LeBlanc, B.P.; Menard, J.E.; Mueller, D.; Sabbagh, S.A.; Stutman, D.; Taylor, G.; Johnson, D.W.; Kaita, R.; Maqueda, R.J.; Ono, M.; Paoletti, F.; Peng, Y-K.M.; Roquemore, A.L.; Skinner, C.H.; Soukhanovskii, V.A.; Synakowski, E.J.

    2001-01-01

    We report observations of the first low-to-high (L-H) confinement mode transitions in the National Spherical Torus Experiment (NSTX). The H-mode energy confinement time increased over reference L-mode discharges transiently by 100-300%, as high as ∼150 ms. This confinement time is ∼1.8-2.3 times higher than predicted by a multi-machine ELM-free H-mode scaling. This achievement extends the H-mode window of fusion devices down to a record low aspect ratio (R/a) ∼ 1.3, challenging both confinement and L-H power thresholds scalings based on conventional aspect ratio tokamaks

  15. Proceedings of A3 foresight program seminar on critical physics issues specific to steady state sustainment of high-performance plasmas

    International Nuclear Information System (INIS)

    Morita, Shigeru; Hu Liqun; Oh, Yeong-Kook

    2013-06-01

    The A3 Foresight Program titled by 'Critical Physics Issues Specific to Steady State Sustainment of High-Performance Plasmas', based on the scientific collaboration among China, Japan and Korea in the field of plasma physics, has been newly started from August 2012 under the auspice of the Japan Society for the Promotion of Science (JSPS, Japan), the National Research Foundation of Korea (NRF, Korea) and the National Natural Science Foundation of China (NSFC, China). A seminar on the A3 collaboration took place in Hotel Gozensui, Kushiro, Japan, 22-25 January 2013. This seminar was organized by National Institute for Fusion Science. One special talk and 36 oral talks were presented in the seminar including 13 Chinese, 14 Japanese and 9 Korean attendees. Steady state sustainment of high-performance plasmas is a crucial issue for realizing a nuclear fusion reactor. This seminar was motivated along the issues. Results on fusion experiments and theory obtained through A3 foresight program during recent two years were discussed and summarized. Possible direction of future collaboration and further encouragement of scientific activity of younger scientists were also discussed in this seminar with future experimental plans in three countries. This issue is the collection of 29 papers presented at the entitled meeting. All the 29 of the presented papers are indexed individually. (J.P.N.)

  16. Molecularly imprinted polymer cartridges coupled on-line with high performance liquid chromatography for simple and rapid analysis of dextromethorphan in human plasma samples.

    Science.gov (United States)

    Moein, Mohammad Mahdi; Javanbakht, Mehran; Akbari-Adergani, Behrouz

    2011-04-01

    In this paper, a novel method is described for automated determination of dextromethorphan in biological fluids using molecularly imprinted solid-phase extraction (MISPE) as a sample clean-up technique combined with high performance liquid chromatography (HPLC). The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker, chloroform as porogen and dextromethorphan as template molecule. These imprinted polymers were used as solid-phase extraction sorbent for the extraction of dextromethorphan from human plasma samples. Various parameters affecting the extraction efficiency of the MIP cartridges were evaluated. The high selectivity of the sorbent coupled to the high performance liquid chromatographic system permitted a simple and rapid analysis of this drug in plasma samples with limits of detection (LOD) and quantification (LOQ) of 0.12 ng/mL and 0.35 ng/mL, respectively. The MIP selectivity was evaluated by analyzing of the dextromethorphan in presence of several substances with similar molecular structures and properties. Results from the HPLC analyses showed that the recoveries of dextromethorphan using MIP cartridges from human plasma samples in the range of 1-50 ng/mL were higher than 87%. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Validation and application of a high-performance liquid chromatography--tandem mass spectrometry assay for mosapride in human plasma.

    Science.gov (United States)

    Ramakrishna, N V S; Vishwottam, K N; Manoj, S; Koteshwara, M; Chidambara, J; Varma, D P

    2005-09-01

    A simple, rapid, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of mosapride (I), a novel and potent gastroprokinetic agent that enhances the upper gastrointestinal motility by stimulating 5-HT(4) receptor. The analyte and internal standard, tamsulosin (II), were extracted by liquid-liquid extraction with diethyl ether-dichloromethane (70:30, v/v) using a Glas-Col Multi-Pulse Vortexer. The chromatographic separation was performed on a reversed-phase Waters symmetry C(18) column with a mobile phase of 0.03% formic acid-acetonitrile (10:90, v/v). The protonated analyte was quantitated in positive ionization by multiple reaction monitoring with a mass spectrometer. The mass transitions m/z 422.3 -->198.3 and m/z 409.1 -->228.1 were used to measure I and II, respectively. The assay exhibited a linear dynamic range of 0.5-100.0 ng/mL for mosapride in human plasma. The lower limit of quantitation was 500 pg/mL with a relative standard deviation of less than 15%. Acceptable precision and accuracy were obtained for concentrations over the standard curve ranges. A run time of 2.0 min for each sample made it possible to analyze a throughput of more than 400 human plasma samples per day. The validated method has been successfully used to analyze human plasma samples for application in pharmacokinetic, bioavailability or bioequivalence studies. Copyright (c) 2005 John Wiley & Sons, Ltd.

  18. High performance SiC detectors for MeV ion beamsgenerated by intense pulsed laser plasmas

    Czech Academy of Sciences Publication Activity Database

    Cutroneo, M.; Musumeci, P.; Zimbone, M.; Torrisi, L.; La Via, F.; Margarone, Daniele; Velyhan, Andriy; Ullschmied, Jiří; Calcagno, L.

    2013-01-01

    Roč. 28, č. 1 (2013), s. 87-93 ISSN 0884-2914 R&D Projects: GA MŠk ED1.1.00/02.0061; GA MŠk EE.2.3.20.0087 Grant - others:ELI Beamlines(XE) CZ.1.05/1.1.00/02.0061; OP VK 2 LaserGen(XE) CZ.1.07/2.3.00/20.0087 Institutional support: RVO:68378271 ; RVO:61389021 Keywords : silicon carbide * ion detectors * high power laser Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.815, year: 2013

  19. Ball-Pen Probe Measurements in L-Mode and H-Mode on ASDEX Upgrade

    Czech Academy of Sciences Publication Activity Database

    Adámek, Jiří; Horáček, Jan; Müller, H. W.; Rohde, V.; Ionita, C.; Schrittwieser, R.; Mehlmann, F.; Kurzan, B.; Stöckel, Jan; Dejarnac, Renaud; Weinzettl, Vladimír; Seidl, Jakub; Peterka, M.

    2010-01-01

    Roč. 50, č. 9 (2010), s. 854-859 ISSN 0863-1042. [International Workshop on Electric Probes in Magnetized Plasmas/8th./. Innsbruck, 21.09.2009-24.09.2009] R&D Projects: GA AV ČR KJB100430901; GA ČR GA202/09/1467 Institutional research plan: CEZ:AV0Z20430508 Keywords : Tokamak * ball- pen probe * electron temperature * L-mode * H-mode * ELMs Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.006, year: 2010 http://onlinelibrary.wiley.com/doi/10.1002/ctpp.201010145/pdf

  20. Papers presented at the 6th H-mode workshop (Seeon, Germany)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The 6th H-mode workshop was held at Kloster Seeon (Germany) during the period of September 22-24, 1997. Contribution to this workshop is reported. Reports include. 1. Role of Nonuniform Superthermal Ions for Internal Transport Barriers. 2. Electric Field Bifurcation and Transition in the Core Plasma of CHS. 3. Formation and Termination of High Ion Temperature Mode in Heliotron/torsatron Plasmas. 4. Transition to an Enhanced Internal Transport Barrier. 5. Physics of Collapses - Probabilistic Occurrence of ELMs and Crashes -. (J.P.N.)

  1. Status of the COMPASS tokamak and characterization of the first H-mode

    Czech Academy of Sciences Publication Activity Database

    Pánek, Radomír; Adámek, Jiří; Aftanas, Milan; Bílková, Petra; Böhm, Petr; Brochard, F.; Cahyna, Pavel; Cavalier, Jordan; Dejarnac, Renaud; Dimitrova, Miglena; Grover, O.; Harrison, J.; Háček, Pavel; Havlíček, Josef; Havránek, Aleš; Horáček, Jan; Hron, Martin; Imríšek, Martin; Janky, Filip; Kirk, A.; Komm, Michael; Kovařík, Karel; Krbec, Jaroslav; Kripner, Lukáš; Markovič, Tomáš; Mitošinková, Klára; Mlynář, Jan; Naydenkova, Diana; Peterka, Matěj; Seidl, Jakub; Stöckel, Jan; Štefániková, Estera; Tomeš, Matěj; Urban, Jakub; Vondráček, Petr; Varavin, Mykyta; Varju, Jozef; Weinzettl, Vladimír; Zajac, Jaromír

    2016-01-01

    Roč. 58, č. 1 (2016), č. článku 014015. ISSN 0741-3335 R&D Projects: GA MŠk(CZ) LM2011021; GA ČR(CZ) GAP205/12/2327; GA ČR(CZ) GA15-10723S Institutional support: RVO:61389021 Keywords : COMPASS * ELM * tokamak * H-mode Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 2.392, year: 2016

  2. A novel freeze-dried storage and preparation method for the determination of mycophenolic acid in plasma by high-performance liquid chromatography.

    Science.gov (United States)

    Wang, Lei; Qiang, Wei; Li, Ying; Cheng, Zeneng; Xie, Mengmeng

    2017-09-01

    Plasma samples were conventionally stored at freezing conditions until the time of detection. Such a technique, when carried out over an extended period, is energy consuming; in addition, preparation and transportation of stored samples is inconvenient. In this study, a freeze-dried storage and preparation method was proposed to determine the presence of mycophenolic acid (MPA) in plasma. Fresh plasma samples were freeze-dried using a device, and then stored at ambient temperature. After the stored samples were soaked with methanol spiked with the internal standard, high-performance liquid chromatography was conducted to detect MPA. The proposed method was demonstrated to be precise and accurate over the linear range of 0.5-50 μg mL -1 , with both intra- and inter-day precision being plasma concentration, time point of maximum plasma concentration and elimination half-life, among others, were consistent with the results in the published study. This proposed technique was proved to be simple, reproducible and energy saving. This approach could also simplify the storage and analysis of samples in clinical and scientific drug research. Copyright © 2017 John Wiley & Sons, Ltd.

  3. Development and validation of reversed-phase high performance liquid chromatographic method for analysis of cephradine in human plasma samples

    International Nuclear Information System (INIS)

    Ahmad, M.; Usman, M.; Madni, A.; Akhtar, N.; Khalid, N.; Asghar, W.

    2010-01-01

    An HPLC method with high precision, accuracy and selectivity was developed and validated for the assessment of cephradine in human plasma samples. The extraction procedure was simple and accurate with single step followed by direct injection of sample into HPLC system. The extracted cephradine in spiked human plasma was separated and quantitated using reversed phase C/sub 18/ column and UV detection wavelength of 254 nm. The optimized mobile phase of new composition of 0.05 M potassium dihydrogen phosphate (pH 3.4)-acetonitrile (88: 12) was pumped at an optimum flow rate of 1 mL.min/sup 1/. The method resulted linearity in the concentration range 0.15- 20 micro g mL/sup -1/. The limit of detection (LOD) and limit of quantification (LOQ) were 0.05 and 0.150 Microg.mL/sup -1/, respectively. The accuracy of method was 98.68 %. This method can 1>e applied for bioequivalence studies and therapeutic drug monitoring as well as for the routine analysis of cephradine. (author)

  4. Determination of total and unbound warfarin and warfarin alcohols in human plasma by high performance liquid chromatography with fluorescence detection.

    Science.gov (United States)

    Lomonaco, Tommaso; Ghimenti, Silvia; Piga, Isabella; Onor, Massimo; Melai, Bernardo; Fuoco, Roger; Di Francesco, Fabio

    2013-11-01

    Two analytical procedures are presented for the determination of the total content and unbound fraction of both warfarin and warfarin alcohols in human plasma. Chromatographic separation was carried out in isocratic conditions at 25°C on a C-18 reversed-phase column with a mobile phase consisting of a 70% buffer phosphate 25mM at pH=7, 25% methanol and 5% acetonitrile at a flow rate of 1.2mL/min. Fluorescence detection was performed at 390nm (excitation wavelength 310nm). Neither method showed any detectable interference or matrix effect. Inter-day recovery of the total warfarin and warfarin alcohols at a concentration level of 1000ng/mL was 89±3% and 73±3%, respectively, whereas for their unbound fraction (at a concentration level of 10ng/mL) was 66±8% and 90±7%, respectively. The intra- and inter-day precision (assessed as relative standard deviation) was alcohols, respectively. The methods were successfully applied to a pooled plasma sample obtained from 69 patients undergoing warfarin therapy. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Correlation of the tokamak H-mode density limit with ballooning stability at the separatrix

    Science.gov (United States)

    Eich, T.; Goldston, R. J.; Kallenbach, A.; Sieglin, B.; Sun, H. J.; ASDEX Upgrade Team; Contributors, JET

    2018-03-01

    We show for JET and ASDEX Upgrade, based on Thomson-scattering measurements, a clear correlation of the density limit of the tokamak H-mode high-confinement regime with the approach to the ideal ballooning instability threshold at the periphery of the plasma. It is shown that the MHD ballooning parameter at the separatrix position α_sep increases about linearly with the separatrix density normalized to Greenwald density, n_e, sep/n_GW for a wide range of discharge parameters in both devices. The observed operational space is found to reach at maximum n_e, sep/n_GW≈ 0.4 -0.5 at values for α_sep≈ 2 -2.5, in the range of theoretical predictions for ballooning instability. This work supports the hypothesis that the H-mode density limit may be set by ballooning stability at the separatrix.

  6. The physics of transport barrier formation in the PBX-M H-mode

    International Nuclear Information System (INIS)

    Tynan, G.R.; Schmitz, L.; Blush, L.

    1994-01-01

    Measurements of edge profiles, turbulence, and turbulent-driven transport were made inside the last-closed flux surface (LCFS) and in the scrape-off layer (SOL) of PBX-M L-mode and H-mode plasmas using a fast reciprocating Langmuir probe diagnostic. Direct measurements of the potential profile confirm the generation of a strong inward radial electric field (E r ∼ -100 V/cm) just inside the LCFS in H-mode. Density and potential fluctuations levels are reduced at the L-H transition, resulting in significantly lower turbulent transport. The reduction in turbulent transport occurs across the LCFS and SOL regions and is not localized to the region of strong radial electric field. (author)

  7. High-performance liquid chromatographic separation of biologically important arsenic species utilizing on-line inductively coupled argon plasma atomic emission spectrometric detection

    Energy Technology Data Exchange (ETDEWEB)

    Spall, W.D.; Lynn, J.G.; Andersen, J.L.; Valdez, J.G.; Gurley, L.R.

    1986-06-01

    An anion exchange, high-performance liquid chromatography technique using a 15-min linear gradient from water to 0.5 M ammonium carbonate to separate arsenite, arsenate, methylarsonic acid, and dimethylarsinic acid from neutral arsenic containing compounds was developed for application to a study of arsenic metabolism in cultured cell suspensions. Arsenic detection was accomplished by the direct coupling of the column effluent to an inductively coupled argon plasma atomic emission spectrometer (ICAP-AES) set to monitor the arsenic emission line at 197.19 nm. The analysis requires 20 min and is sensitive to as low as 60 ng of arsenic injected to the column.

  8. Coherent edge fluctuation measurements in H-mode discharges on JFT-2M

    International Nuclear Information System (INIS)

    Nagashima, Y; Shinohara, K; Hoshino, K; Ejiri, A; Tsuzuki, K; Ido, T; Uehara, K; Kawashima, H; Kamiya, K; Ogawa, H; Yamada, T; Shiraiwa, S; Ohara, S; Takase, Y; Asakura, N; Oyama, N; Fujita, T; Ide, S; Takenaga, H; Kusama, Y; Miura, Y

    2004-01-01

    Results of coherent edge fluctuation measurements using three diagnostics (a reciprocating Langmuir probe, a two channel O-mode reflectometer, and fast magnetic probes) in H-mode discharges on JFT-2M are presented. In discharges in which a high recycling steady (HRS) H-mode phase is obtained through a transient phase with slightly enhanced D α intensity, two types of coherent fluctuations are observed. The higher frequency mode (around 300 kHz) is the high frequency mode (HFM) observed in the HRS H-mode (Kamiya K et al 2003 9th IAEA Tech. Meeting H-mode Workshop Topic B-14). The lower frequency mode has a frequency of around 80 kHz. The HFM is detected by a Langmuir probe over a wide region in the SOL, as well as by the reflectometer and magnetic probes. However, the HFM is not detected by the higher frequency (38 GHz) channel of the reflectometer after the HRS transition, suggesting that the HFM is not located deeply inside the plasma. The 80 kHz mode is detected by both channels of the reflectometer and by a Langmuir probe, but not by magnetic probes, suggesting that it is an electrostatic mode. In contrast to the HFM, the 80 kHz mode is detected by the Langmuir probe only near the separatrix during the transient phase, which leads to either the HRS phase or the ELMy phase, and is similar to the fluctuations reported in Shinohara K et al (1998 J. Plasma Fusion Res. 74 607)

  9. Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry

    NARCIS (Netherlands)

    Damen, Carola W. N.; Israëls, Trijn; Caron, Huib N.; Schellens, Jan H. M.; Rosing, Hilde; Beijnen, Jos H.

    2009-01-01

    A sensitive, specific and efficient high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the simultaneous determination of total vincristine and actinomycin-D concentrations in human plasma and an assay for the determination of unbound vincristine are presented.

  10. Simultaneous determination of ribavirin and ribavirin base in monkey plasma by high performance liquid chromatography with tandem mass spectrometry.

    Science.gov (United States)

    Li, Wenkui; Luo, Suyi; Li, Shaoyong; Athill, Lawrence; Wu, Amy; Ray, Tapan; Zhou, Wei; Ke, June; Smith, Harold T; Tse, Francis L S

    2007-02-01

    For the first time, a liquid chromatographic method with tandem mass spectrometric detection (LC-MS/MS) for the simultaneous determination of ribavirin and rabavirin base was developed and validated over the concentration range of 10-5,000 ng/ml, respectively, using a 0.025 ml monkey plasma sample. Ribavirin, ribavirin base, and the internal standards were extracted from monkey plasma via protein precipitation. After evaporation of the supernatant, the extract was reconstituted with 5% methanol (containing 0.1% formic acid) and injected onto the LC-MS/MS system. Optimum chromatographic separation was achieved on a Waters Atlantis dc18 (150 mm x 2.1mm, 5 microm) column with mobile phase run in gradient with 100% water containing 0.5% formic acid (A) and 90% acetonitrile (containing 0.5% formic acid (B). The flow rate was 0.4-0.6 ml/min with total cycle time of approximately 7.0 min. Post-column addition of acetonitrile (containing 0.1% formic acid) at 0.3 ml/min was used to increase the ionization efficiency in the MS source. The method was validated for sensitivity, linearity, reproducibility, stability and recovery. Lack of adverse matrix effect and carry-over was also demonstrated. The intra-day and inter-day precision and accuracy of the quality control (QC) samples were <9.0% relative standard deviation (R.S.D.) and 10.8% bias for ribavirin, and 10.3% R.S.D. and 11.3% bias for ribavirin base. The current specific, accurate and precise assay is useful in support of the toxicokinetic and pharmacokinetic studies of these compounds.

  11. Analysis of 6-mercaptopurine in human plasma with a high-performance liquid chromatographic method including post-column derivatization and fluorimetric detection.

    Science.gov (United States)

    Jonkers, R E; Oosterhuis, B; ten Berge, R J; van Boxtel, C J

    1982-12-10

    A relatively simple assay with improved reliability and sensitivity for measuring levels of 6-mercaptopurine in human plasma is presented. After extraction of the compound and the added internal standard with phenyl mercury acetate, samples were separated by ion-pair reversed-phase high-performance liquid chromatography. On-line the analytes were oxidized to fluorescent products and detected in a flow-fluorimeter. The within-day coefficient of variation was 3.8% at a concentration of 25 ng/ml. The lower detection limit was 2 ng/ml when 1.0 ml of plasma was used. Mercaptopurine concentration versus time curves of two subjects after a single oral dose of azathioprine are shown.

  12. MHD stability of JET high performance discharges. Comparison of MHD calculations with experimental observations

    International Nuclear Information System (INIS)

    Huysmans, G.

    1998-03-01

    One of the aims of the JET, the Joint European Torus, project is to optimise the maximum fusion performance as measured by the neutron rate. At present, two different scenarios are developed at JET to achieve the high performance the so-called Hot-Ion H-mode scenario and the more recent development of the Optimised Shear scenario. Both scenarios have reached similar values of the neutron rate in Deuterium plasmas, up to 5 10 17 neutrons/second. Both scenarios are characterised by a transport barrier, i.e., a region in the plasma where the confinement is improved. The Hot-Ion H-mode has a transport barrier at the plasma boundary just inside the separatrix, an Optimised Shear plasma exhibits a transport barrier at about mid radius. Associated with the improved confinement of the transport barriers are locally large pressure gradients. It is these pressure gradients which, either directly or indirectly, can drive MHD instabilities. The instabilities limit the maximum performance. In the optimised shear scenario a global MHD instability leads to a disruptive end of the discharge. In the Hot-Ion H-mode plasmas, so-called Outer Modes can occur which are localised at the plasma boundary and lead to a saturation of the plasma performance. In this paper, two examples of the MHD instabilities are discussed and identified by comparing the experimentally observed modes with theoretical calculations from the ideal MHD code MISHKA-1. Also, the MHD stability boundaries of the two scenarios are presented. Section 3 contains a discussion of the mode observed just before the disruption

  13. Sensitive determination of 4-O-methylhonokiol in rabbit plasma by high performance liquid chromatography and application to its pharmacokinetic investigation

    Directory of Open Access Journals (Sweden)

    Ming-Yue Li

    2011-05-01

    Full Text Available A novel high Performance liquid Chromatographie method was developed for the determination of 4-O-methylhonokiol in rabbit plasma and was applied to its pharmacokinetic investigation. Plasma samples were treated by one-fold volume of methanol and acetonitrile to remove the interference proteins. A reverse phase column of SHIM-PACK VP-ODS (150 mm × 4.6 mm, 5.0 Mm was used to separate 4-O-methylhonokiol in the plasma samples. The detection limit of 4-O-methylhonokiol was 0.2 μg/L and the linear ränge was 0.012 – 1.536 μg/L. The good extraction recoveries were obtained for the spiked samples (84.7%, 89.3% and 87.7% for low, middle and high concentrations of added Standards, respectively. The relative standard deviation of intra-day and inter-day precisions was in the ränge from 0.6% to 13.5%. The pharmacokinetic study of 4-O-methylhonokiol was made and the results from the plasma-concentration curve of 4-O-methylhonokiol showed a two-apartment open model. This work developed a sensitive, stable and rapid HPLC method for the determination of 4-O-methylhonokiol and the developed method has been successfully applied to a pharmacokinetic study of 4-O-methylhonokiol. Keywords: 4-O-methylhonokiol, Cortex Magnoliae Officinalis, high Performance liquid chromatography, pharmacokinetic

  14. A new boundary control scheme for simultaneous achievement of H-mode and radiative cooling (SHC boundary)

    International Nuclear Information System (INIS)

    Ohyabu, N.

    1995-05-01

    We have proposed a new boundary control scheme (SHC boundary), which could allow simultaneous achievement of the H-mode type confinement improvement and radiative cooling with wide heat flux distribution. In our proposed configuration, a low m island layer sharply separates a plasma confining region from an open 'ergodic' boundary. The degree of openness in the ergodic boundary must be high enough to make the plasma pressure constant along the field line, which in turn separates low density plasma just outside the plasma confining region (the key external condition for achieving a good H-mode discharge) from very high density, cold radiative plasma near the wall (required for effective edge radiative cooling). Examples of such proposed SHC boundaries for Heliotron typed devices and tokamaks are presented. (author)

  15. Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography-ultraviolet detection to determination of opium alkaloids in human plasma.

    Science.gov (United States)

    Ahmadi-Jouibari, Toraj; Fattahi, Nazir; Shamsipur, Mojtaba; Pirsaheb, Meghdad

    2013-11-01

    A novel, simple, rapid and sensitive dispersive liquid-liquid microextraction method based on the solidification of floating organic drop (DLLME-SFO) combined with high-performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to determine opium alkaloids in human plasma. During the extraction procedure, plasma protein was precipitated by using a mixture of zinc sulfate solution and acetonitrile. Some effective parameters on extraction were studied and optimized. Under the optimum conditions (extraction solvent: 30.0 μl 1-undecanol; disperser solvent: 470 μl acetone; pH: 9; salt addition: 1%(w/v) NaCl and extraction time: 0.5 min), calibration curves are linear in the range of 1.5-1000 μgl(-1) and limit of detections (LODs) are in the range of 0.5-5 μgl(-1). The relative standard deviations (RSDs) for 100 μgl(-1) of morphine and codeine, 10.0 μgl(-1) of papaverine and 20.0 μgl(-1) of noscapine in diluted human plasma are in the range of 4.3-7.4% (n=5). Finally, the method was successfully applied in the determination of opium alkaloids in the actual human plasma samples. The relative recoveries of plasma samples spiked with alkaloids are 88-110.5%. The obtained results show that DLLME-SFO combined with HPLC-UV is a fast and simple method for the determination of opium alkaloids in human plasma. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. High-performance Liquid Chromatographic Ultraviolet Detection of Nilotinib in Human Plasma from Patients with Chronic Myelogenous Leukemia, and Comparison with Liquid Chromatography-Tandem Mass Spectrometry.

    Science.gov (United States)

    Nakahara, Ryosuke; Satho, Yuhki; Itoh, Hiroki

    2016-11-01

    A method for determining nilotinib concentration in human plasma is proposed using high-performance liquid chromatography and ultraviolet detection. Nilotinib and the internal standard dasatinib were separated using a mobile phase of 0.5% Na 2 PO 4 H 2 O (pH 2.5)-acetonitrile-methanol (55:25:20, v/v/v) on a Capcell Pak C18 MG II column (250 × 4.6 mm) at a flow rate of 1.0 ml/min, and ultraviolet measurement at 250 nm. The calibration curve exhibited linearity over the nilotinib concentration range of 50-2,500 ng/ml at 250 nm, with relative standard deviations (n = 5) of 7.1%, 2.5%, and 2.9% for 250, 1,500, and 2,500 ng/ml, respectively. The detection limit for nilotinib was 5 ng/ml due to three blank determinations (ρ = 3). This method was successfully applied to assaying nilotinib in human plasma samples from patients with chronic myelogenous leukemia. In addition, we compared the results with those measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) at BML, Inc. (a commercial laboratory). A strong correlation was observed between the nilotinib concentrations measured by our high-performance liquid chromatographic method and those obtained by LC/MS-MS (r 2 = 0.988, P < 0.01). © 2016 Wiley Periodicals, Inc.

  17. H-mode transition physics close to DN on MAST and its applications to other tokamaks

    International Nuclear Information System (INIS)

    Meyer, H.

    2004-01-01

    Full text: ELMy H-mode is the base-line operating scenario for the next step fusion device ITER. To improve active and passive pedestal control a deeper understanding of H- mode physics is desirable. MAST contributes towards this understanding with good edge diagnostics, and by accessing extreme parameter regimes. The first inter-machine comparisons with respect to the influence of the magnetic topology on the power threshold with ASDEX-Upgrade and NSTX reveal a reduction of the power threshold in true double null (C-DN) configuration opening new operation regimes in both devices. The 30% reduction in threshold power close to C-DN observed on ASDEX-Upgrade, though significant, is less than the factor of two or more observed in both large spherical tokamaks, MAST and NSTX. This points towards the importance of field line curvature for this effect. The power thresholds measured in C-DN on MAST and NSTX are very similar. Despite this strong effect on the power threshold, changes in most edge parameters in L-mode due to the different magnetic configurations are small. However, significant changes are seen in the toroidal impurity flow velocity, related to the radial electric field, and in the scrape-off-layer temperature decay length at the high field side. The statistical comparison of MAST data with various H-mode theories suggests that different instabilities need to be stabilised at different spatial positions in the region where the pedestal forms to access H-mode. Pedestal temperatures observed on MAST are two to five times lower than in MAST equivalent discharges at ASDEX-Upgrade. However, the pedestal densities are similar. The differences in L-mode are less significant. The usual DN operating regime with co current NBI in MAST has been extended to include single null (SN) configurations, to provide more direct comparisons with conventional tokamaks. The plasma edge in SN on MAST is more stable to ELMs and the typical type-III ELMs, often observed in C-DN, are

  18. Gyrokinetic Calculations of Microinstabilities and Transport During RF H-Modes on Alcator C-Mod

    International Nuclear Information System (INIS)

    Redi, M.H.; Fiore, C.; Bonoli, P.; Bourdelle, C.; Budny, R.; Dorland, W.D.; Ernst, D.; Hammett, G.; Mikkelsen, D.; Rice, J.; Wukitch, S.

    2002-01-01

    Physics understanding for the experimental improvement of particle and energy confinement is being advanced through massively parallel calculations of microturbulence for simulated plasma conditions. The ultimate goal, an experimentally validated, global, non-local, fully nonlinear calculation of plasma microturbulence is still not within reach, but extraordinary progress has been achieved in understanding microturbulence, driving forces and the plasma response in recent years. In this paper we discuss gyrokinetic simulations of plasma turbulence being carried out to examine a reproducible, H-mode, RF heated experiment on the Alcator CMOD tokamak3, which exhibits an internal transport barrier (ITB). This off axis RF case represents the early phase of a very interesting dual frequency RF experiment, which shows density control with central RF heating later in the discharge. The ITB exhibits steep, spontaneous density peaking: a reduction in particle transport occurring without a central particle source. Since the central temperature is maintained while the central density is increasing, this also suggests a thermal transport barrier exists. TRANSP analysis shows that ceff drops inside the ITB. Sawtooth heat pulse analysis also shows a localized thermal transport barrier. For this ICRF EDA H-mode, the minority resonance is at r/a * 0.5 on the high field side. There is a normal shear profile, with q monotonic

  19. Edge ion dynamics in H-mode discharges in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Burrell, K.H.; Gohil, P.; Kim, J.; Seraydarian, R.P.

    1992-05-01

    The goal of this paper is to present detailed measurements of T i and E r at the plasma edge in L- and H-mode with high spatial resolution in order the study the edge ion dynamics. Of primary interest is the relationship between T i and E r and the behavior of the edge T i profile in H-mode. The principle findings are: there appears to be a threshold temperature for T i required for the transition to occur with T i at the LCFS in the range of 0.2--0.3 keV at the transition; a correlation between the edge E r profile and the edge T i profile has been observed; and values of T i of 2--3 keV within a few cm of the LCFS and of dT i /dr of up to 1 keV/cm are observed in the transport barrier in H-mode, with the scale length for T i being of the order of a poloidal gyroradius

  20. Comparison of H-mode barrier width with a model of neutral penetration length

    International Nuclear Information System (INIS)

    Groebner, R.J.; Mahdavi, M.A.; Leonard, A.W.; Osborne, T.H.; Brooks, N.S.; Wolf, N.S.; Porter, G.D.; Stangeby, P.C.; Colchin, R.J.; Owen, L.W.

    2004-01-01

    Pedestal studies in DIII-D find that the width of the region of steep gradient in the H-mode density is comparable with the neutral penetration length, as computed from a simple analytic model. This model has analytic solutions for the edge plasma and neutral density profiles, which are obtained from the coupled particle continuity equations for electrons and deuterium atoms. In its range of validity (edge temperature between 40 and 500 eV), the analytic model quantitatively predicts the observed decrease in the width as the pedestal density increases and the observed strong increase in the gradient of the density as the pedestal density increases. The model successfully predicts that L-mode and H-mode profiles with the same pedestal density have gradients that differ by less than a factor of 2. The width of the density barrier, measured from the edge of the electron temperature barrier, is the lower limit for the observed width of the temperature barrier. These results support the hypothesis that particle fuelling is an important part of the physics that determines the structure of the H-mode transport barrier. (author)

  1. A newly validated high-performance liquid chromatography method with diode array ultraviolet detection for analysis of the antimalarial drug primaquine in the blood plasma.

    Science.gov (United States)

    Carmo, Ana Paula Barbosa do; Borborema, Manoella; Ribeiro, Stephan; De-Oliveira, Ana Cecilia Xavier; Paumgartten, Francisco Jose Roma; Moreira, Davyson de Lima

    2017-01-01

    Primaquine (PQ) diphosphate is an 8-aminoquinoline antimalarial drug with unique therapeutic properties. It is the only drug that prevents relapses of Plasmodium vivax or Plasmodium ovale infections. In this study, a fast, sensitive, cost-effective, and robust method for the extraction and high-performance liquid chromatography with diode array ultraviolet detection (HPLC-DAD-UV ) analysis of PQ in the blood plasma was developed and validated. After plasma protein precipitation, PQ was obtained by liquid-liquid extraction and analyzed by HPLC-DAD-UV with a modified-silica cyanopropyl column (250mm × 4.6mm i.d. × 5μm) as the stationary phase and a mixture of acetonitrile and 10mM ammonium acetate buffer (pH = 3.80) (45:55) as the mobile phase. The flow rate was 1.0mL·min-1, the oven temperature was 50OC, and absorbance was measured at 264nm. The method was validated for linearity, intra-day and inter-day precision, accuracy, recovery, and robustness. The detection (LOD) and quantification (LOQ) limits were 1.0 and 3.5ng·mL-1, respectively. The method was used to analyze the plasma of female DBA-2 mice treated with 20mg.kg-1 (oral) PQ diphosphate. By combining a simple, low-cost extraction procedure with a sensitive, precise, accurate, and robust method, it was possible to analyze PQ in small volumes of plasma. The new method presents lower LOD and LOQ limits and requires a shorter analysis time and smaller plasma volumes than those of previously reported HPLC methods with DAD-UV detection. The new validated method is suitable for kinetic studies of PQ in small rodents, including mouse models for the study of malaria.

  2. Determination of oxycodone and its major metabolites noroxycodone and oxymorphone by ultra-high-performance liquid chromatography tandem mass spectrometry in plasma and urine: application to real cases.

    Science.gov (United States)

    Pantano, Flaminia; Brauneis, Stefano; Forneris, Alexandre; Pacifici, Roberta; Marinelli, Enrico; Kyriakou, Chrystalla; Pichini, Simona; Busardò, Francesco Paolo

    2017-08-28

    Oxycodone is a narcotic drug widely used to alleviate moderate and severe acute and chronic pain. Variability in analgesic efficacy could be explained by inter-subject variations in plasma concentrations of parent drug and its active metabolite, oxymorphone. To evaluate patient compliance and to set up therapeutic drug monitoring (TDM), an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay was developed and validated for the parent drug and its major metabolites noroxycodone and oxymorphone. Extraction of analytes from plasma and urine samples was obtained by simple liquid-liquid extraction. The chromatographic separation was achieved with a reversed phase column using a linear gradient elution with two solvents: acetic acid 1% in water and methanol. The separated analytes were detected with a triple quadrupole mass spectrometer operated in multiple reaction monitoring (MRM) mode via positive electrospray ionization (ESI). Separation of analytes was obtained in less than 5 min. Linear calibration curves for all the analytes under investigation in urine and plasma samples showed determination coefficients (r2) equal or higher than 0.990. Mean absolute analytical recoveries were always above 86%. Intra- and inter-assay precision (measured as coefficient of variation, CV%) and accuracy (measured as % error) values were always better than 13%. Limit of detection at 0.06 and 0.15 ng/mL and limit of quantification at 0.2 and 0.5 ng/mL for plasma and urine samples, respectively, were adequate for the purpose of the present study. Rapid extraction, identification and quantification of oxycodone and its metabolites both in urine and plasma by UHPLC-MS/MS assay was tested for its feasibility in clinical samples and provided excellent results for rapid and effective drug testing in patients under oxycodone treatment.

  3. A newly validated high-performance liquid chromatography method with diode array ultraviolet detection for analysis of the antimalarial drug primaquine in the blood plasma

    Directory of Open Access Journals (Sweden)

    Ana Paula Barbosa do Carmo

    Full Text Available Abstract INTRODUCTION: Primaquine (PQ diphosphate is an 8-aminoquinoline antimalarial drug with unique therapeutic properties. It is the only drug that prevents relapses of Plasmodium vivax or Plasmodium ovale infections. In this study, a fast, sensitive, cost-effective, and robust method for the extraction and high-performance liquid chromatography with diode array ultraviolet detection (HPLC-DAD-UV analysis of PQ in the blood plasma was developed and validated. METHODS: After plasma protein precipitation, PQ was obtained by liquid-liquid extraction and analyzed by HPLC-DAD-UV with a modified-silica cyanopropyl column (250mm × 4.6mm i.d. × 5μm as the stationary phase and a mixture of acetonitrile and 10mM ammonium acetate buffer (pH = 3.80 (45:55 as the mobile phase. The flow rate was 1.0mL·min-1, the oven temperature was 50OC, and absorbance was measured at 264nm. The method was validated for linearity, intra-day and inter-day precision, accuracy, recovery, and robustness. The detection (LOD and quantification (LOQ limits were 1.0 and 3.5ng·mL-1, respectively. The method was used to analyze the plasma of female DBA-2 mice treated with 20mg.kg-1 (oral PQ diphosphate. RESULTS: By combining a simple, low-cost extraction procedure with a sensitive, precise, accurate, and robust method, it was possible to analyze PQ in small volumes of plasma. The new method presents lower LOD and LOQ limits and requires a shorter analysis time and smaller plasma volumes than those of previously reported HPLC methods with DAD-UV detection. CONCLUSIONS: The new validated method is suitable for kinetic studies of PQ in small rodents, including mouse models for the study of malaria.

  4. Simultaneous high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) analysis of cyanide and thiocyanate from swine plasma.

    Science.gov (United States)

    Bhandari, Raj K; Manandhar, Erica; Oda, Robert P; Rockwood, Gary A; Logue, Brian A

    2014-01-01

    An analytical procedure for the simultaneous determination of cyanide and thiocyanate in swine plasma was developed and validated. Cyanide and thiocyanate were simultaneously analyzed by high-performance liquid chromatography tandem mass spectrometry in negative ionization mode after rapid and simple sample preparation. Isotopically labeled internal standards, Na(13)C(15)N and NaS(13)C(15)N, were mixed with swine plasma (spiked and nonspiked), proteins were precipitated with acetone, the samples were centrifuged, and the supernatant was removed and dried. The dried samples were reconstituted in 10 mM ammonium formate. Cyanide was reacted with naphthalene-2,3-dicarboxaldehyde and taurine to form N-substituted 1-cyano[f]benzoisoindole, while thiocyanate was chemically modified with monobromobimane to form an SCN-bimane product. The method produced dynamic ranges of 0.1-50 and 0.2-50 μM for cyanide and thiocyanate, respectively, with limits of detection of 10 nM for cyanide and 50 nM for thiocyanate. For quality control standards, the precision, as measured by percent relative standard deviation, was below 8 %, and the accuracy was within ±10 % of the nominal concentration. Following validation, the analytical procedure successfully detected cyanide and thiocyanate simultaneously from the plasma of cyanide-exposed swine.

  5. The importance of the radial electric field (Er) on interpretation of motional Stark effect measurements of the q profile in DIII-D high performance plasmas

    International Nuclear Information System (INIS)

    Rice, B.W.; Lao, L.L.; Burrell, K.H.; Greenfield, C.M.; Lin-Liu, Y.R.

    1997-06-01

    The development of enhanced confinement regimes such as negative central magnetic shear (NCS) and VH-mode illustrates the importance of the q profile and ExB velocity shear in improving stability and confinement in tokamak plasmas. Recently, it was realized that the large values of radial electric field observed in these high performance plasmas, up to 200 kV/m in DIII-D, have an effect on the interpretation of motional Stark effect (MSE) measurements of the q profile. It has also been shown that, with additional MSE measurements, one can extract a direct measurement of E r in addition to the usual poloidal field measurement. During a recent vent on DIII-D, 19 additional MSE channels with new viewing angles were added (for a total of 35 channels) in order to descriminate between the neutral beam v b x B electric field and the plasma E r field. In this paper, the system upgrade will be described and initial measurements demonstrating simultaneous measurement of the q and E r profiles will be presented

  6. Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

    Science.gov (United States)

    Wang, Xiaoming; Rytting, Erik; Abdelrahman, Doaa R.; Nanovskaya, Tatiana N.; Hankins, Gary D.V.; Ahmed, Mahmoud S.

    2013-01-01

    The liquid chromatography with electrospray ionization mass spectrometry for the quantitative determination of famotidine in human urine, maternal and umbilical cord plasma was developed and validated. The plasma samples were alkalized with ammonium hydroxide and extracted twice with ethyl acetate. The extraction recovery of famotidine in maternal and umbilical cord plasma ranged from 53% to 64% and 72% to 79%, respectively. Urine samples were directly diluted with the initial mobile phase then injected into the HPLC system. Chromatographic separation of famotidine was achieved by using a Phenomenex Synergi™ Hydro-RP™ column with a gradient elution of acetonitrile and 10 mM ammonium acetate aqueous solution (pH 8.3, adjusted with ammonium hydroxide). Mass Spectrometric detection of famotidine was set in the positive mode and used a selected ion monitoring method. Carbon-13-labeled famotidine was used as internal standard. The calibration curves were linear (r2> 0.99) in the concentration ranges of 0.631-252 ng/mL for umbilical and maternal plasma samples, and of 0.075-30.0 μg/mL for urine samples. The relative deviation of method was less than 14% for intra- and inter-day assays, and the accuracy ranged between 93% and 110%. The matrix effect of famotidine in human urine, maternal and umbilical cord plasma is less than 17%. PMID:23401067

  7. Density profile analysis during an ELM event in ASDEX Upgrade H-modes

    International Nuclear Information System (INIS)

    Nunes, I.; Manso, M.; Serra, F.; Horton, L.D.; Conway, G.D.; Loarte, A.

    2005-01-01

    This paper reports results on measurements of the density profiles. Here we analyse the behaviour of the electron density for a set of experiments in type I ELMy H-mode discharges in ASDEX Upgrade where the plasma current, plasma density, triangularity and input power were varied. Detailed measurements of the radial extent of the perturbation on the density profiles caused by the edge localized mode (ELM) crash (ELM affected depth), the velocity of the radial propagation of the perturbation as well as the width and gradient of the density pedestal are determined. The effect of a type I ELM event on the density profiles affects the outermost 20-40% of the plasma minor radius. At the scrape-off layer (SOL) the density profile broadens while in the pedestal region the density decreases resulting in a smaller density gradient. This change in the density profile defines a pivot point around which the density profile changes. The average radial velocity at the SOL is in the range 125-150 ms -1 and approximately constant for all the density layers far from the pivot point. The width of the density pedestal is approximately constant for all the ELMy H-mode discharges analysed, with values between 2 and 3.5 cm. These results are then compared with an analytical model where the width of the density is predominantly set by ionization (neutral penetration model). The width of the density profiles for L-mode discharges is included, since L- and H-mode have different particle transport. No agreement between the experimental results and the model is found

  8. Transport simulation of EAST long-pulse H-mode discharge with integrated modeling

    Science.gov (United States)

    Wu, M. Q.; Li, G. Q.; Chen, J. L.; Du, H. F.; Gao, X.; Ren, Q. L.; Li, K.; Chan, Vincent; Pan, C. K.; Ding, S. Y.; Jian, X.; Zhu, X.; Lian, H.; Qian, J. P.; Gong, X. Z.; Zang, Q.; Duan, Y. M.; Liu, H. Q.; Lyu, B.

    2018-04-01

    In the 2017 EAST experimental campaign, a steady-state long-pulse H-mode discharge lasting longer than 100 s has been obtained using only radio frequency heating and current drive, and the confinement quality is slightly better than standard H-mode, H98y2 ~ 1.1, with stationary peaked electron temperature profiles. Integrated modeling of one long-pulse H-mode discharge in the 2016 EAST experimental campaign has been performed with equilibrium code EFIT, and transport codes TGYRO and ONETWO under integrated modeling framework OMFIT. The plasma current is fully-noninductively driven with a combination of ~2.2 MW LHW, ~0.3 MW ECH and ~1.1 MW ICRF. Time evolution of the predicted electron and ion temperature profiles through integrated modeling agree closely with that from measurements. The plasma current (I p ~ 0.45 MA) and electron density are kept constantly. A steady-state is achieved using integrated modeling, and the bootstrap current fraction is ~28%, the RF drive current fraction is ~72%. The predicted current density profile matches the experimental one well. Analysis shows that electron cyclotron heating (ECH) makes large contribution to the plasma confinement when heating in the core region while heating in large radius does smaller improvement, also a more peaked LHW driven current profile is got when heating in the core. Linear analysis shows that the high-k modes instability (electron temperature gradient driven modes) is suppressed in the core region where exists weak electron internal transport barriers. The trapped electron modes dominates in the low-k region, which is mainly responsible for driving the electron energy flux. It is found that the ECH heating effect is very local and not the main cause to sustained the good confinement, the peaked current density profile has the most important effect on plasma confinement improvement. Transport analysis of the long-pulse H-mode experiments on EAST will be helpful to build future experiments.

  9. Development and validation of a high-performance liquid chromatography method for the quantification of talazoparib in rat plasma: Application to plasma protein binding studies.

    Science.gov (United States)

    Hidau, Mahendra Kumar; Kolluru, Srikanth; Palakurthi, Srinath

    2018-02-01

    A sensitive and selective RP-HPLC method has been developed and validated for the quantification of a highly potent poly ADP ribose polymerase inhibitor talazoparib (TZP) in rat plasma. Chromatographic separation was performed with isocratic elution method. Absorbance for TZP was measured with a UV detector (SPD-20A UV-vis) at a λ max of 227 nm. Protein precipitation was used to extract the drug from plasma samples using methanol-acetonitrile (65:35) as the precipitating solvent. The method proved to be sensitive and reproducible over a 100-2000 ng/mL linearity range with a lower limit of quantification (LLQC) of 100 ng/mL. TZP recovery was found to be >85%. Following analytical method development and validation, it was successfully employed to determine the plasma protein binding of TZP. TZP has a high level of protein binding in rat plasma (95.76 ± 0.38%) as determined by dialysis method. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Status of the COMPASS tokamak and characterization of the first H-mode

    Science.gov (United States)

    Pánek, R.; Adámek, J.; Aftanas, M.; Bílková, P.; Böhm, P.; Brochard, F.; Cahyna, P.; Cavalier, J.; Dejarnac, R.; Dimitrova, M.; Grover, O.; Harrison, J.; Háček, P.; Havlíček, J.; Havránek, A.; Horáček, J.; Hron, M.; Imríšek, M.; Janky, F.; Kirk, A.; Komm, M.; Kovařík, K.; Krbec, J.; Kripner, L.; Markovič, T.; Mitošinková, K.; Mlynář, J.; Naydenkova, D.; Peterka, M.; Seidl, J.; Stöckel, J.; Štefániková, E.; Tomeš, M.; Urban, J.; Vondráček, P.; Varavin, M.; Varju, J.; Weinzettl, V.; Zajac, J.; the COMPASS Team

    2016-01-01

    This paper summarizes the status of the COMPASS tokamak, its comprehensive diagnostic equipment and plasma scenarios as a baseline for the future studies. The former COMPASS-D tokamak was in operation at UKAEA Culham, UK in 1992-2002. Later, the device was transferred to the Institute of Plasma Physics of the Academy of Sciences of the Czech Republic (IPP AS CR), where it was installed during 2006-2011. Since 2012 the device has been in a full operation with Type-I and Type-III ELMy H-modes as a base scenario. This enables together with the ITER-like plasma shape and flexible NBI heating system (two injectors enabling co- or balanced injection) to perform ITER relevant studies in different parameter range to the other tokamaks (ASDEX-Upgrade, DIII-D, JET) and to contribute to the ITER scallings. In addition to the description of the device, current status and the main diagnostic equipment, the paper focuses on the characterization of the Ohmic as well as NBI-assisted H-modes. Moreover, Edge Localized Modes (ELMs) are categorized based on their frequency dependence on power density flowing across separatrix. The filamentary structure of ELMs is studied and the parallel heat flux in individual filaments is measured by probes on the outer mid-plane and in the divertor. The measurements are supported by observation of ELM and inter-ELM filaments by an ultra-fast camera.

  11. Plasma L-ergothioneine measurement by high-performance liquid chromatography and capillary electrophoresis after a pre-column derivatization with 5-iodoacetamidofluorescein (5-IAF) and fluorescence detection.

    Science.gov (United States)

    Sotgia, Salvatore; Pisanu, Elisabetta; Pintus, Gianfranco; Erre, Gian Luca; Pinna, Gerard Aime; Deiana, Luca; Carru, Ciriaco; Zinellu, Angelo

    2013-01-01

    Two sensitive and reproducible capillary electrophoresis and high-performance liquid chromatography-fluorescence procedures were established for quantitative determination of L-egothioneine in plasma. After derivatization of L-ergothioneine with 5-iodoacetamidofluorescein, the separation was carried out by HPLC on an ODS-2 C-18 sperisorb column by using a linear gradient elution and by HPCE on an uncoated fused silica capillary, 50 µm id, and 60 cm length. The methods were validated and found to be linear in the range of 0.3 to 10 µmol/l. The limit of quantification was 0.27 µmol/l for HPCE and 0.15 µmol/l for HPLC. The variations for intra- and inter-assay precision were around 6 RSD%, and the mean recovery accuracy close to 100% (96.11%).

  12. Determination of pharmacological levels of harmane, harmine and harmaline in mammalian brain tissue, cerebrospinal fluid and plasma by high-performance liquid chromatography with fluorimetric detection.

    Science.gov (United States)

    Moncrieff, J

    1989-11-24

    Increased blood aldehyde levels, as occur in alcohol intoxication, could lead to the formation of beta-carbolines such as harmane by condensation with indoleamines. Endogenous beta-carbolines, therefore, should occur in specific brain areas where indoleamine concentrations are high, whilst exogenous beta-carbolines should exhibit an even distribution. The author presents direct and sensitive methods for assaying the beta-carbolines harmane, harmine and harmaline in brain tissue, cerebrospinal fluid and plasma at picogram sample concentrations using reversed-phase high-performance liquid chromatography with fluorimetric detection and minimal sample preparation. Using these assay methods, it was found that the distribution of beta-carbolines from a source exogenous to the brain results in a relatively even distribution within the brain tissue.

  13. Speciation of eight arsenic compounds in human urine by high performance liquid chromatography with inductively coupled plasma mass spectrometric detection using antimonate for internal chromatographic standardization

    DEFF Research Database (Denmark)

    Larsen, Erik Huusfeldt; Pritzl, G.; Hansen, S. H.

    1993-01-01

    Four anionic and four cationic arsenic compounds in urine were separated by anion- and cation-exchange high-performance liquid chromatography and detected by inductively coupled plasma mass spectrometry (ICP-MS) at m/z 75. The species were the anions arsenite, arsenate, monomethylarsonate...... and dimethylarsinate and the cations arsenobetaine, trimethylarsine oxide, arsenocholine and the tetramethylarsonium ion. Hexahydroxyantimonate(III) was co-chromatographed with the arsenic anions but detected at m/z 121 and used as an internal standard for their qualitative analysis. Arsenite was prone to oxidation....... The argon chloride interference at m/z 75 was eliminated by chromatographic separation of the chloride present in the sample from the arsenic analytes. The ClO+ ion detected at m/z 51 and 53 was used to monitor the retention time of chloride in the anion-exchange system. The chloride eluted about 100 s...

  14. Metabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometry.

    Science.gov (United States)

    Zhou, Ying; Hu, Pei; Jiang, Ji

    2017-04-15

    Remimazolam is a new chemical entity belonging to the benzodiazepine class of sedative drugs, which shows faster-acting onset and recovery than currently available short-acting sedatives. In the present study, ultra high performance liquid chromatography with synapt high-definition mass spectrometry method combined with MassLynx software was established to characterize metabolites of remimazolam in human plasma and urine. In total, 5 human metabolites were detected, including 3 phase I and 2 phase II metabolites. There was no novel human metabolite detected compared to that in rat. Hydrolysis, glucuronidation and oxidation were the major metabolic reactions. To our knowledge, this is the first report of the human metabolic profile of remimazolam. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. A rapid monitoring method for inorganic arsenic in rice flour using reversed phase-high performance liquid chromatography-inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Narukawa, Tomohiro; Chiba, Koichi; Sinaviwat, Savarin; Feldmann, Jörg

    2017-01-06

    A new rapid monitoring method by means of high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) following the heat-assisted extraction was developed for measurement of total inorganic arsenic species in rice flour. As(III) and As(V) eluted at the same retention time and completely separated from organoarsenic species by an isocratic elution program on a reversed phase column. Therefore, neither ambiguous oxidation of arsenite to arsenate nor the integration of two peaks were necessary to determine directly the target analyte inorganic arsenic. Rapid injection allowed measuring 3 replicates within 6min and this combined with a quantitative extraction of all arsenic species from rice flour by a 15min HNO 3 -H 2 O 2 extraction makes this the fastest laboratory based method for inorganic arsenic in rice flour. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Effect of Wave Accessibility on Lower Hybrid Wave Current Drive in Experimental Advanced Superconductor Tokamak with H-Mode Operation

    International Nuclear Information System (INIS)

    Li Xin-Xia; Xiang Nong; Gan Chun-Yun

    2015-01-01

    The effect of the wave accessibility condition on the lower hybrid current drive in the experimental advanced superconductor Tokamak (EAST) plasma with H-mode operation is studied. Based on a simplified model, a mode conversion layer of the lower hybrid wave between the fast wave branch and the slow wave branch is proved to exist in the plasma periphery for typical EAST H-mode parameters. Under the framework of the lower hybrid wave simulation code (LSC), the wave ray trajectory and the associated current drive are calculated numerically. The results show that the wave accessibility condition plays an important role on the lower hybrid current drive in EAST plasma. For wave rays with parallel refractive index n ‖ = 2.1 or n ‖ = 2.5 launched from the outside midplane, the wave rays may penetrate the core plasma due to the toroidal geometry effect, while numerous reflections of the wave ray trajectories in the plasma periphery occur. However, low current drive efficiency is obtained. Meanwhile, the wave accessibility condition is improved if a higher confined magnetic field is applied. The simulation results show that for plasma parameters under present EAST H-mode operation, a significant lower hybrid wave current drive could be obtained for the wave spectrum with peak value n ‖ = 2.1 if a toroidal magnetic field B T = 2.5 T is applied. (paper)

  17. Stability at high performance in the MAST spherical tokamak

    International Nuclear Information System (INIS)

    Buttery, R.J.; Akers, R.; Arends, E. =

    2003-01-01

    The development of reliable H-modes on MAST, together with advances in heating power and a range of powerful diagnostics, has provided a platform to enable MAST to address some of he most important issues of tokamak stability. In particular the high β potential of the ST is highlighted with stable operation at β N ∼5-6 , β T ∼ 16% and β p as high as 1.9, confirmed by a range of profile diagnostics. Calculations indicate that β N levels are in the vicinity of no-wall stability limits. Studies have provided the first identification of the Neoclassical Tearing Mode (NTM) in the ST, using its behaviour to quantitatively validate predictions of NTM theory, previously only applied to conventional tokamaks. Experiments have demonstrated that sawteeth play a strong role in triggering NTMs - by avoiding large sawteeth much higher β N can, and has, been reached. Further studies have confirmed the NTM's significance, with large islands observed using the 300 point Thomson diagnostic, and locking of large n=1 modes frequently leading to disruptions. H-mode plasmas are also limited by ELMs, with confinement degraded as ELM frequency rises. However, unlike the conventional tokamak, the ELMs in high performing regimes on MAST (H IPB98Y2 ∼1) appear to be type III in nature. Modelling identifies instability to peeling modes, consistent with a type III interpretation, and shows considerable scope to raise pressure gradients (despite n=∞ ballooning theory predictions of instability) before ballooning type modes (perhaps associated with type I ELMs) occur. Finally sawteeth are shown not to remove the q=1 surface in the ST - other promising models are being explored. Thus research on MAST is not only demonstrating stable operation at high performance levels, and developing methods to control instabilities; it is also providing detailed tests of the stability physics and models applicable to conventional tokamaks, such as ITER. (author)

  18. Quantitative determination of regorafenib and its two major metabolites in human plasma with high-performance liquid chromatography and ultraviolet detection.

    Science.gov (United States)

    Fujita, Kazuma; Miura, Masatomo; Shibata, Hiroyuki

    2016-10-01

    A simple, highly sensitive and specific high-performance liquid chromatography (HPLC) method was developed for the simultaneous quantitation of regorafenib, N-oxidemetabolite (M-2) and the desmethyl N-oxide metabolite (M-5) in human plasma. Regorafenib, M-2, M-5 and the internal standard sorafenib were separated using a mobile phase of 0.5% KH2 PO4 (pH 3.5)-acetonitrile (30:70, v/v), on a Capcell PAK MG II column at a flow rate of 0.5 mL/min and measurement at UV 260 nm. The lower limits of quantification for regorafenib, M-2 and M-5 were 10 ng/mL for each analyte. A procedure using solid-phase extraction required only a small amount of plasma (100 μL) for one analysis while providing high extraction recovery (>81% for all compounds) and good selectivity. Coefficients of variation for intra- and inter-day assays were HPLC assay is suitable for clinical pharmacokinetic studies of regorafenib. The present HPLC method is currently in use for our observational studies of patients under treatment. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  19. A Wide Linearity Range Method for the Determination of Lenalidomide in Plasma by High-Performance Liquid Chromatography: Application to Pharmacokinetic Studies.

    Science.gov (United States)

    Guglieri-López, Beatriz; Pérez-Pitarch, Alejandro; Martinez-Gómez, Maria Amparo; Porta-Oltra, Begoña; Climente-Martí, Mónica; Merino-Sanjuán, Matilde

    2016-12-01

    A wide linearity range analytical method for the determination of lenalidomide in patients with multiple myeloma for pharmacokinetic studies is required. Plasma samples were ultrasonicated for protein precipitation. A solid-phase extraction was performed. The eluted samples were evaporated to dryness under vacuum, and the solid obtained was diluted and injected into the high-performance liquid chromatography (HPLC) system. Separation of lenalidomide was performed on an Xterra RP C18 (250 mm length × 4.6 mm i.d., 5 µm) using a mobile phase consisting of phosphate buffer/acetonitrile (85:15, v/v, pH 3.2) at a flow rate of 0.5 mL · min -1 The samples were monitored at a wavelength of 311 nm. A linear relationship with good correlation coefficient (r = 0.997, n = 9) was found between the peak area and lenalidomide concentrations in the range of 100 to 950 ng · mL -1 The limits of detection and quantitation were 28 and 100 ng · mL -1 , respectively. The intra- and interassay precisions were satisfactory, and the accuracy of the method was proved. In conclusion, the proposed method is suitable for the accurate quantification of lenalidomide in human plasma with a wide linear range, from 100 to 950 ng · mL -1 This is a valuable method for pharmacokinetic studies of lenalidomide in human subjects. © 2016 Society for Laboratory Automation and Screening.

  20. Determination of rifampicin in human plasma by high-performance liquid chromatography coupled with ultraviolet detection after automatized solid-liquid extraction.

    Science.gov (United States)

    Louveau, B; Fernandez, C; Zahr, N; Sauvageon-Martre, H; Maslanka, P; Faure, P; Mourah, S; Goldwirt, L

    2016-12-01

    A precise and accurate high-performance liquid chromatography (HPLC) quantification method of rifampicin in human plasma was developed and validated using ultraviolet detection after an automatized solid-phase extraction. The method was validated with respect to selectivity, extraction recovery, linearity, intra- and inter-day precision, accuracy, lower limit of quantification and stability. Chromatographic separation was performed on a Chromolith RP 8 column using a mixture of 0.05 m acetate buffer pH 5.7-acetonitrile (35:65, v/v) as mobile phase. The compounds were detected at a wavelength of 335 nm with a lower limit of quantification of 0.05 mg/L in human plasma. Retention times for rifampicin and 6,7-dimethyl-2,3-di(2-pyridyl) quinoxaline used as internal standard were respectively 3.77 and 4.81 min. This robust and exact method was successfully applied in routine for therapeutic drug monitoring in patients treated with rifampicin. Copyright © 2016 John Wiley & Sons, Ltd.

  1. Method for the quantification of vanadyl porphyrins in fractions of crude oils by High Performance Liquid Chromatography-Flow Injection-Inductively Coupled Plasma Mass Spectrometry

    Science.gov (United States)

    Wandekoken, Flávia G.; Duyck, Christiane B.; Fonseca, Teresa C. O.; Saint'Pierre, Tatiana D.

    2016-05-01

    High performance liquid chromatography hyphenated by flow injection to inductively coupled plasma mass spectrometry (HPLC-FI-ICP-MS) was used to investigate V linked to porphyrins present in fractions of crude oil. First, the crude oil sample was submitted to fractionation by preparative liquid chromatography with UV detection, at the porphyrin Soret band wavelength (400 nm). The obtained porphyrin fractions were then separated in a 250 mm single column, in the HPLC, and eluted with different mobile phases (methanol or methanol:toluene (80:20; v:v)). The quantification of V-porphyrins in the fractions eluted from HPLC was carried out by online measuring the 51V isotope in the ICP-MS, against vanadyl octaethylporphine standard solutions (VO-OEP), prepared in the same solvent as the mobile phase, and injected post-column directly into the plasma. A 20 μg L- 1 Ge in methanol was used as internal standard for minimizing non-spectral interference, such as short-term variations due to injection. The mathematical treatment of the signal based on Fast Fourier Transform smoothing algorithm was employed to improve the precision. The concentrations of V as V-porphyrins were between 2.7 and 11 mg kg- 1 in the fractions, which were close to the total concentration of V in the porphyrin fractions of the studied crude oil.

  2. Fast Determination of Toxic Arsenic Species in Food Samples Using Narrow-bore High-Performance Liquid-Chromatography Inductively Coupled Plasma Mass Spectrometry.

    Science.gov (United States)

    Terol, Amanda; Marcinkowska, Monika; Ardini, Francisco; Grotti, Marco

    2016-01-01

    A new method for the speciation analysis of arsenic in food using narrow-bore high-performance liquid-chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) has been developed. Fast separation of arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid was carried out in 7 min using an anion-exchange narrow-bore Nucleosil 100 SB column and 12 mM ammonium dihydrogen phosphate of pH 5.2 as the mobile phase, at a flow rate of 0.3 mL min(-1). A PFA-ST micronebulizer jointed to a cyclonic spray chamber was used for HPLC-ICP-MS coupling. Compared with standard-bore HPLC-ICP-MS, the new method has provided higher sensitivity, reduced mobile-phase consumption, a lower matrix plasma load and a shorter analysis time. The achieved instrumental limits of detection were in the 0.3 - 0.4 ng As mL(-1) range, and the precision was better than 3%. The arsenic compounds were efficiently (>80%) extracted from various food samples using a 1:5 methanol/water solution, with additional ultrasonic treatment for rice products. The applicability of this method was demonstrated by the analysis of several samples, such as seafood (fish, mussels, shrimps, edible algae) and rice-based products (Jasmine and Arborio rice, spaghetti, flour, crackers), including three certified reference materials.

  3. Ultra High Performance Liquid Chromatography Method for the Determination of Two Recently FDA Approved TKIs in Human Plasma Using Diode Array Detection

    Directory of Open Access Journals (Sweden)

    Marwa Fouad

    2015-01-01

    Full Text Available Generally, tyrosine kinase inhibitors have narrow therapeutic window and large interpatient variability compared to intrapatient variability. In order to support its therapeutic drug monitoring, two fast and accurate methods were developed for the determination of recently FDA approved anticancer tyrosine kinase inhibitors, afatinib and ibrutinib, in human plasma using ultra high performance liquid chromatography coupled to PDA detection. Diclofenac sodium was used as internal standard. The chromatographic separation was achieved on an Acquity UPLC BEH C18 analytical column using a mobile phase combining ammonium formate buffer and acetonitrile at a constant flow rate of 0.4 mL/min using gradient elution mode. A µSPE (solid phase extraction procedure, using Oasis MCX µElution plates, was processed and it gave satisfying and reproducible results in terms of extraction yields. Additionally, the methods were successfully validated using the accuracy profiles approach (β = 95% and acceptance limits = ±15% over the ranges 5–250 ng/mL for afatinib and from 5 to 400 ng/mL for ibrutinib in human plasma.

  4. Determination of atenolol in human plasma using ionic-liquid-based ultrasound-assisted in situ solvent formation microextraction followed by high-performance liquid chromatography.

    Science.gov (United States)

    Zeeb, Mohsen; Farahani, Hadi; Papan, Mohammad Kazem

    2016-06-01

    An efficient analytical method called ionic-liquid-based ultrasound-assisted in situ solvent formation microextraction followed by high-performance liquid chromatography was developed for the determination of atenolol in human plasma. A hydrophobic ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) was formed by the addition of a hydrophilic ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate) to a sample solution containing an ion-pairing agent during microextraction. The analyte was extracted into the ionic liquid phase while the microextraction solvent was dispersed throughout the sample by utilizing ultrasound. The sample was then centrifuged, and the extracting phase retracted into the microsyringe and injected to liquid chromatography. After optimization, the calibration curve showed linearity in the range of 2-750 ng/mL with the regression coefficient corresponding to 0.998. The limits of detection (S/N = 3) and quantification (S/N = 10) were 0.5 and 2 ng/mL, respectively. A reasonable relative recovery range of 90-96.7% and satisfactory intra-assay (4.8-5.1%, n = 6) and interassay (5.0-5.6%, n = 9) precision along with a substantial sample clean-up demonstrated good performance of the procedure. It was applied for the determination of atenolol in human plasma after oral administration and some pharmacokinetic data were obtained. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Determination of torasemide in human plasma and its bioequivalence study by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry

    Directory of Open Access Journals (Sweden)

    Lin Zhang

    2016-04-01

    Full Text Available A sensitive and selective method using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC–ESI–MS to determine the concentration of torasemide in human plasma samples was developed and validated. Tolbutamide was chosen as the internal standard (IS. The chromatography was performed on a Gl Sciences Inertsil ODS-3 column (100 mm×2.1 mm i.d., 5.0 µm within 5 min, using methanol with 10 mM ammonium formate (60:40, v/v as mobile phase at a flow rate of 0.2 mL/min. The targeted compound was detected in negative ionization at m/z 347.00 for torasemide and 269.00 for IS. The linearity range of this method was found to be within the concentration range of 1–2500 ng/mL (r=0.9984 for torasemide in human plasma. The accuracy of this measurement was between 94.05% and 103.86%. The extracted recovery efficiency was from 84.20% to 86.47% at three concentration levels. This method was also successfully applied in pharmacokinetics and bioequivalence studies in Chinese volunteers.

  6. A simple and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry method to determine plasma biotin in hemodialysis patients.

    Science.gov (United States)

    Yagi, Shigeaki; Nishizawa, Manabu; Ando, Itiro; Oguma, Shiro; Sato, Emiko; Imai, Yutaka; Fujiwara, Masako

    2016-08-01

    A simple, rapid, and selective method for determination of plasma biotin was developed using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After single-step protein precipitation with methanol, biotin and stable isotope-labeled biotin as an internal standard (IS) were chromatographed on a pentafluorophenyl stationary-phase column (2.1 × 100 mm, 2.7 μm) under isocratic conditions using 10 mm ammonium formate-acetonitrile (93:7, v/v) at a flow rate of 0.6 mL/min. The total chromatographic runtime was 5 min for each injection. Detection was performed in a positive electrospray ionization mode by monitoring selected ion transitions at m/z 245.1/227.0 and 249.1/231.0 for biotin and the IS, respectively. The calibration curve was linear in the range of 0.05-2 ng/mL using 300 μL of plasma. The intra- and inter-day precisions were all biotin concentrations in hemodialysis patients. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  7. Simultaneous extraction and quantification of lamotrigine, phenobarbital, and phenytoin in human plasma and urine samples using solidified floating organic drop microextraction and high-performance liquid chromatography.

    Science.gov (United States)

    Asadi, Mohammad; Dadfarnia, Shayessteh; Haji Shabani, Ali Mohammad; Abbasi, Bijan

    2015-07-01

    A novel and simple method based on solidified floating organic drop microextraction followed by high-performance liquid chromatography with ultraviolet detection has been developed for simultaneous preconcentration and determination of phenobarbital, lamotrigine, and phenytoin in human plasma and urine samples. Factors affecting microextraction efficiency such as the type and volume of the extraction solvent, sample pH, extraction time, stirring rate, extraction temperature, ionic strength, and sample volume were optimized. Under the optimum conditions (i.e. extraction solvent, 1-undecanol (40 μL); sample pH, 8.0; temperature, 25°C; stirring rate, 500 rpm; sample volume, 7 mL; potassium chloride concentration, 5% and extraction time, 50 min), the limits of detection for phenobarbital, lamotrigine, and phenytoin were 1.0, 0.1, and 0.3 μg/L, respectively. Also, the calibration curves for phenobarbital, lamotrigine, and phenytoin were linear in the concentration range of 2.0-300.0, 0.3-200.0, and 1.0-200.0 μg/L, respectively. The relative standard deviations for six replicate extractions and determinations of phenobarbital, lamotrigine, and phenytoin at 50 μg/L level were less than 4.6%. The method was successfully applied to determine phenobarbital, lamotrigine, and phenytoin in plasma and urine samples. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Application of high performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for determination of chromium compounds in the air at the workplace.

    Science.gov (United States)

    Stanislawska, Magdalena; Janasik, Beata; Wasowicz, Wojciech

    2013-12-15

    The toxicity and bioavailability of chromium species are highly dependable on the form or species, therefore determination of total chromium is insufficient for a complete toxicological evaluation and risk assessment. An analytical method for determination of soluble and insoluble Cr (III) and Cr (VI) compounds in welding fume at workplace air has been developed. The total chromium (Cr) was determined by using quadruple inductively coupled plasma mass spectrometry (ICP-MS) equipped with a dynamic reaction cell (DRC(®)). Soluble trivalent and hexavalent chromium compounds were determined by high performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). A high-speed, reversed-phase CR C8 column (PerkinElmer, Inc., Shelton, CT, USA) was used for the speciation of soluble Cr (III) and soluble Cr (VI). The separation was accomplished by interaction of the chromium species with the different components of the mobile phase. Cr (III) formed a complex with EDTA, i.e. retained on the column, while Cr (VI) existed in the solutions as dichromate. Alkaline extraction (2% KOH and 3% Na2CO3) and anion exchange column (PRP-X100, PEEK, Hamilton) were used for the separation of the total Cr (VI). The results of the determination of Cr (VI) were confirmed by the analysis of the certified reference material BCR CRM 545 (Cr (VI) in welding dust). The results obtained for the certified material (40.2±0.6 g kg(-1)) and the values recorded in the examined samples (40.7±0.6 g kg(-1)) were highly consistent. This analytical method was applied for the determination of chromium in the samples in the workplace air collected onto glass (Whatman, Ø 37 mm) and membrane filters (Sartorius, 0.8 μm, Ø 37 mm). High performance liquid chromatography with inductively coupled plasma mass spectrometry is a remarkably powerful and versatile technique for determination of chromium species in welding fume at workplace air. Crown Copyright © 2013 Published by

  9. Superparamagnetic graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of tamsulosin hydrochloride in human plasma by high performance liquid chromatography-ultraviolet detection.

    Science.gov (United States)

    Pashaei, Yaser; Ghorbani-Bidkorbeh, Fatemeh; Shekarchi, Maryam

    2017-05-26

    In the present study, superparamagnetic graphene oxide-Fe 3 O 4 nanocomposites were successfully prepared by a modified impregnation method (MGO mi ) and their application as a sorbent in the magnetic-dispersive solid phase extraction (M-dSPE) mode to the preconcentration and determination of tamsulosin hydrochloride (TMS) in human plasma was investigated by coupling with high performance liquid chromatography-ultraviolet detection (HPLC-UV). The structure, morphology and magnetic properties of the prepared nanocomposites were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and vibrating sample magnetometry (VSM). Some factors affecting the extraction efficiency, including the pH value, amount of sorbent, extraction time, elution solvent and its volume, and desorption time were studied and optimized. Magnetic nanocomposites plasma extraction of TMS following HPLC analyses showed a linear calibration curve in the range of 0.5-50.0ngmL -1 with an acceptable correlation coefficient (R 2 =0.9988). The method was sensitive, with a low limit of detection (0.17ngmL -1 ) and quantification (0.48ngmL -1 ). Inter- and intra-day precision expressed as relative standard deviation (n=3) and the preconcentration factor, were found to be 5.6-7.2%, 2.9-4.2% and 10, respectively. Good recoveries (98.1-101.4%) with low relative standard deviations (4.2-5.0%) indicated that the matrices under consideration do not significantly affect the extraction process. Due to its high precision and accuracy, the developed method may be a HPLC-UV alternative with M-dSPE for bioequivalence analysis of TMS in human plasma. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Determination and pharmacokinetic properties of arsenic speciation in Xiao-Er-Zhi-Bao-Wan by high-performance liquid chromatography with inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Han, Xu; Luo, Jiaoyang; Zhou, Wenju; Yang, Shihai; Yang, Meihua

    2016-10-01

    A method of high performance liquid chromatography with a Hamilton PRP-X100 ion-exchange column (250 × 4.1 mm id, 10 μm) coupled to inductively coupled plasma mass spectrometry was employed to generate a full concentration-time profile of arsenic speciation after oral administration. The results exhibited good linearity and revealed that, in the pills, the average arsenic concentration was 10105.4 ± 380.7 mg/kg, and in the water extraction solution, the inorganic As(III) and As(V) concentrations were 220.1 ± 12.6 and 45.5 ± 2.3 mg/kg, respectively. No trace of monomethyl arsenic acid was detected in any of the plasma samples. We then successfully applied the established methodology to examine the pharmacokinetics of arsenic speciation. The resulting data revealed that, after oral administration in rats, the plasma concentration of each arsenic species reached C max shortly after initial dosing, and that the distribution and elimination of As(V) was faster than that of As(III) and dimethyl arsenic acid. Additionally, the t 1/2 values of As(V), As(III), and dimethyl arsenic acid were 3.4 ± 1.6, 14.3 ± 4.0, and 19.9 ± 1.6 h, respectively. This study provides references for the determination of arsenic speciation in mineral-containing medicines and could serve as a useful tool in measuring the true toxicity in traditional medicines that contain them. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. New high performance liquid chromatographic method for simultaneous determination of diclofenac and meloxicam in oral formulation of liposomes and human plasma

    International Nuclear Information System (INIS)

    Madni, A.; Ahmad, M.; Usman, M.; Zubair, M.M.; Shoiab, H.M.; Khan, S.A.; Qureshi, M.S.

    2010-01-01

    A new, easy and consistent reversed-phase high-performance liquid chromatographic method with diode array detection has been developed and validated for the simultaneous determination of diclofenac potassium (DP) and meloxicam (MLX) in liposome, marketed brands and human plasma. Microextraction method based on liquid-liquid extraction principal was used to extract drug from plasma matrix. The optimized mobile phase was used in the molar ratio of 20:20:60 (v/v/v) mixture of acetonitrile, methanol and 20 x 10/sup -3/ M potassium dihydrogen phosphate buffer (pH 3.7), pumped at an optimized flow rate of 1.0 mL.min/sup -1/. The linearity was performed in the concentration range of 15 ng.mL/sup -1/ to 10 mu g.mL/sup -1/ with gamma/sup 2/ of 0.9989 +- 0.13 and 0.9979 +- 0.11 (n = 6) for DP and MLX, respectively. The assay was repeatable at concentration levels of 10 ng.mL/sup -1/, 1 mu g.mL/sup -1/ and 10 mu g.mL/sup -1/ with coefficient of variation of 0.168 - 0.603% for 10 ng.mL-1 (DP), 15 ng.mL/sup -/1 (MLX) and 1 mu g.mL/sup -1/ and 10 mu g.mL/sup -1/ for DP and MLX. The LOD values were 3 and 5 ng.mL/sup -1/, while values of LOQ were 10 and 15 ng.mL/sup =11, for DP and MLX. The present method is applicable in routine quality control operations, advanced drug delivery formulations (Liposomes) and in human Plasma samples for pharmacokinetics and bioequivalence studies. (author)

  12. High-performance liquid chromatography with time-programmed fluorescence detection for the quantification of Levofloxacin in human plasma and cerebrospinal fluid in adults with tuberculous meningitis.

    Science.gov (United States)

    Van Toi, Pham; Pouplin, Thomas; Tho, Nguyen Duc Khanh; Phuong, Pham Nguyen; Chau, Tran Thi Hong; Thuong Thuong, Nguyen Thuy; Heemskerk, Dorothee; Hien, Tran Tinh; Thwaites, Guy E

    2017-09-01

    An accurate and reliable high-performance liquid chromatography with time-programmed fluorescence detection was developed and validated to measure levofloxacin in human plasma and cerebrospinal fluid (CSF). After solid phase extraction process using Evolute ® ABN 96 fixed well plate; levofloxacin and internal standard-enoxacin were separated using a mobile phase consisting of phosphate buffer 10mM with 0.025% triethylamine pH 3.0 - acetonitrile (88:12, v/v) on a Purosphere RP-8e column (5μm, 125×4.0mm) at a flow rate of 1.2mL/min at 35°C. The excitation/emission wavelengths were set to 269/400nm and 294/500nm, for enoxacin and levofloxacin, respectively. The method was linear over the concentration range of 0.02 to 20.0μg/mL with a limit of detection of 0.01μg/mL. The relative standard deviation of intra-assay and inter-assay precision for levofloxacin at four quality controls concentrations (0.02, 0.06, 3.0 and 15.0μg/mL) were less than 7% and the accuracies ranged from 96.75% to 101.9% in plasma, and from 93.00% to 98.67% in CSF. The validated method was successfully applied to quantify levofloxacin in a considerable quantity of plasma (826) and CSF (477) samples collected from 232 tuberculous meningitis patients, and the preliminary intensive pharmacokinetics analysis from 14 tuberculous meningitis patients in Vietnam is described in this paper. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Ultra high performance liquid chromatography-tandem mass spectrometry vs. commercial immunoassay for determination of vancomycin plasma concentration in children. Possible implications for everyday clinical practice.

    Science.gov (United States)

    Barco, Sebastiano; Castagnola, Elio; Gennai, Iulian; Barbagallo, Laura; Loy, Anna; Tripodi, Gino; Cangemi, Giuliana

    2016-10-01

    Vancomycin therapeutic drug monitoring (TDM) is necessary for effective and safetherapy. The aim of the this paper was to develop a specific and robust ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for vancomycin quantification starting from low plasma volumes to be applied for the routine TDM in children. Samples from children receiving intravenous vancomycin were analysed using a TSQ Quantum Access MAX Triple Quadrupole system coupled with an Accela 1250 UHPLC system after a rapid protein precipitation. Gradient separation chromatography was carried out using a Hypersil GOLD aQ C18 column (50 × 2.1 mm, particle size 1.9 μm). Method performance was validated following international guidelines. UHPLC-MS/MS allowed a rapid and specific quantification of vancomycin over the range 0.1-128 μg/mL from 50 μL of plasma with high reproducibility and accuracy in the absence of matrix effect. The comparison with the commercial immunoassay performed on 138 samples demonstrated the presence of a proportional bias. The concentrations of vancomycin measured with immunoassay were found to be 4.5% (95% CI: 1.3-7.7) higher than those determined with UHPLC-MS/MS. Importantly, a clinical discordance was found in about 10% of samples analysed. This new UHPLC-MS/MS method is accurate and specific for the measurement of vancomycin starting from small (50 μL) plasma volumes. The use of UHPLC-MS/MS is recommended to prevent a misclassification of therapeutic or toxic vancomycin levels in paediatrics.

  14. H-mode transition physics close to double null on MAST and its applications to other tokamaks

    International Nuclear Information System (INIS)

    Meyer, H.; Carolan, P.G.; Cunningham, G.; Kirk, A.; Lloyd, B.; Saarelma, S.; Wilson, H.R.; Conway, G.D.; Horton, L.D.; Ryter, F.; Schirmer, J.; Suttrop, W.; Maingi, R.

    2005-01-01

    By accessing extreme parameter regimes combined with well diagnosed edge MAST data contribute towards the understanding of H-mode physics. The first inter-machine comparisons with respect to the influence of the magnetic topology on the power threshold with ASDEX Upgrade and NSTX reveal a reduction of the power threshold in true double null (C-DN) configuration opening new operation regimes in both devices. In L-mode, the negative radial electric field close to the separatrix was found to be more negative in C-DN than in single null (SN), whilst most of the other edge parameters are similar. Pedestal temperatures in MAST are lower than in ASDEX Upgrade in MAST-equivalent discharges, whereas the pedestal densities can be similar, although in long inter ELM periods the MAST density pedestal is higher than on ASDEX Upgrade. In order to test four leading H-mode theories MAST data are compared statistically to their H-mode access criteria. The usual DN operating regime with co current NBI in MAST has been extended to include single null (SN) configurations, to provide more direct comparisons with conventional tokamaks. The plasma edge in SN on MAST is more stable to ELMs and the typical type-III ELMs, often observed in C-DN, are absent, despite input powers close to the H-mode threshold power. In this respect, the stability of measured plasma edge profiles in SN and DN against ideal peeling-ballooning modes will be discussed. (author)

  15. H-mode pedestal and threshold studies over an expanded operating space on Alcator C-Moda)

    Science.gov (United States)

    Hubbard, A. E.; Hughes, J. W.; Bespamyatnov, I. O.; Biewer, T.; Cziegler, I.; LaBombard, B.; Lin, Y.; McDermott, R.; Rice, J. E.; Rowan, W. L.; Snipes, J. A.; Terry, J. L.; Wolfe, S. M.; Wukitch, S.

    2007-05-01

    This paper reports on studies of the edge transport barrier and transition threshold of the high confinement (H) mode of operation on the Alcator C-Mod tokamak [I. H. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)], over a wide range of toroidal field (2.6-7.86T) and plasma current (0.4-1.7MA). The H-mode power threshold and edge temperature at the transition increase with field. Barrier widths, pressure limits, and confinement are nearly independent of field at constant current, but the operational space at high B shifts toward higher temperature and lower density and collisionality. Experiments with reversed field and current show that scrape-off-layer flows in the high-field side depend primarily on configuration. In configurations with the B ×∇B drift away from the active X-point, these flows lead to more countercurrent core rotation, which apparently contributes to higher H-mode thresholds. In the unfavorable case, edge temperature thresholds are higher, and slow evolution of profiles indicates a reduction in thermal transport prior to the transition in particle confinement. Pedestal temperatures in this case are also higher than in the favorable configuration. Both high-field and reversed-field results suggest that parameters at the L-H transition are influencing the evolution and parameters of the H-mode pedestal.

  16. Determination of plasma concentrations of levofloxacin by high performance liquid chromatography for use at a multidrug-resistant tuberculosis hospital in Tanzania.

    Science.gov (United States)

    Ebers, Andrew; Stroup, Suzanne; Mpagama, Stellah; Kisonga, Riziki; Lekule, Isaack; Liu, Jie; Heysell, Scott

    2017-01-01

    Therapeutic drug monitoring may improve multidrug-resistant tuberculosis (MDR-TB) treatment outcomes. Levofloxacin demonstrates significant individual pharmacokinetic variability. Thus, we sought to develop and validate a high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection for levofloxacin in patients on MDR-TB treatment. The HPLC-UV method is based on a solid phase extraction (SPE) and a direct injection into the HPLC system. The limit of quantification was 0.25 μg/mL, and the assay was linear over the concentration range of 0.25-15 μg/mL (y = 0.5668x-0.0603, R2 = 0.9992) for the determination of levofloxacin in plasma. The HPLC-UV methodology achieved excellent accuracy and reproducibility along a clinically meaningful range. The intra-assay RSD% of low, medium, and high quality control samples (QC) were 1.93, 2.44, and 1.90, respectively, while the inter-assay RSD% were 3.74, 5.65, and 3.30, respectively. The mean recovery was 96.84%. This method was then utilized to measure levofloxacin concentrations from patients' plasma samples from a retrospective cohort of consecutive enrolled subjects treated for MDR-TB at the national TB hospital in Tanzania during 5/3/2013-8/31/2015. Plasma was collected at 2 hours after levofloxacin administration, the time of estimated peak concentration (eCmax) treatment. Forty-one MDR-TB patients had plasma available and 39 had traceable programmatic outcomes. Only 13 (32%) patients had any plasma concentration that reached the lower range of the expected literature derived Cmax with the median eCmax being 5.86 (3.33-9.08 μg/ml). Using Classification and Regression Tree analysis, an eCmax ≥7.55 μg/mL was identified as the threshold which best predicted cure. Analyzing this CART derived threshold on treatment outcome, the time to sputum culture conversion was 38.3 ± 22.7 days vs. 47.8 ± 26.5 days (p = 0.27) and a greater proportion were cured, in 10 out of 15 (66.7%) vs. 6 out of 18 (33.3%) (p

  17. Correlation of H-mode density barrier width and neutral penetration length

    International Nuclear Information System (INIS)

    Groebner, R.J.

    2002-01-01

    Pedestal studies in DIII-D find a good correlation between the width of the H-mode particle barrier width(ne) and the neutral penetration length. These results are obtained by comparing experimental n e profiles to the predictions of an analytic model for the density profile, obtained from a solution of the particle continuity equations for electrons and deuterium atoms. Initial bench-marking shows that the model is consistent with the fluid neutrals model of the UEDGE code. In its range of validity (edge temperature between 0.02-0.3 keV), the model quantitatively predicts the observed values of width(ne), the observed decrease of width(ne) as the pedestal density n e,ped increases, the observed increase of the gradient of n e with the square of n e,ped , and the observation that L-mode and H-mode profiles with the same n e,ped have very similar widths. In the model, width(ne) depends on the fuelling source and on the plasma transport. Thus, these results provide evidence that the width of the particle barrier depends on both plasma physics and atomic physics. (author)

  18. Development of ITER 15 MA ELMy H-mode Inductive Scenario

    International Nuclear Information System (INIS)

    C. E. Kessel, D. Campbell, Y. Gribov, G. Saibene, G. Ambrosino, T. Casper, M. Cavinato, H. Fujieda, R. Hawryluk, L. D. Horton, A. Kavin, R. Kharyrutdinov, F. Koechl, J. Leuer, A. Loarte, P. J. Lomas, T. Luce, V. Lukash, M. Mattei, I.Nunes, V. Parail, A. Polevoi, A. Portone, R. Sartori, A.C.C. Sips, P. R. Thomas, A. Welander and J. Wesley

    2008-01-01

    The poloidal field (PF) coil system on ITER, which provides both feedforward and feedback control of plasma position, shape, and current, is a critical element for achieving mission performance. Analysis of PF capabilities has focused on the 15 MA Q = 10 scenario with a 300-500 s flattop burn phase. The operating space available for the 15 MA ELMy H-mode plasma discharges in ITER and upgrades to the PF coils or associated systems to establish confidence that ITER mission objectives can be reached have been identified. Time dependent self-consistent free-boundary calculations were performed to examine the impact of plasma variability, discharge programming, and plasma disturbances. Based on these calculations a new reference scenario was developed based upon a large bore initial plasma, early divertor transition, low level heating in L-mode, and a late H-mode onset. Equilibrium analyses for this scenario indicate that the original PF coil limitations do not allow low li (<0.8) operation or lower flux states, and the flattop burn durations were predicted to be less than the desired 400 s. This finding motivates the expansion of the operating space, considering several upgrade options to the PF coils. Analysis was also carried out to examine the feedback current reserve required in the CS and PF coils during a series of disturbances and a feasibility assessment of the 17 MA scenario was undertaken. Results of the studies show that the new scenario and modified PF system will allow a wide range of 15 MA 300-500 s operation and more limited but finite 17 MA operation

  19. JT-60U high performance regimes

    International Nuclear Information System (INIS)

    Ishida, S.

    1999-01-01

    High performance regimes of JT-60U plasmas are presented with an emphasis upon the results from the use of a semi-closed pumped divertor with W-shaped geometry. Plasma performance in transient and quasi steady states has been significantly improved in reversed shear and high- βp regimes. The reversed shear regime elevated an equivalent Q DT eq transiently up to 1.25 (n D (0)τ E T i (0)=8.6x10 20 m-3·s·keV) in a reactor-relevant thermonuclear dominant regime. Long sustainment of enhanced confinement with internal transport barriers (ITBs) with a fully non-inductive current drive in a reversed shear discharge was successfully demonstrated with LH wave injection. Performance sustainment has been extended in the high- bp regime with a high triangularity achieving a long sustainment of plasma conditions equivalent to Q DT eq ∼0.16 (n D (0)τ E T i (0)∼1.4x10 20 m -3 ·s·keV) for ∼4.5 s with a large non-inductive current drive fraction of 60-70% of the plasma current. Thermal and particle transport analyses show significant reduction of thermal and particle diffusivities around ITB resulting in a strong Er shear in the ITB region. The W-shaped divertor is effective for He ash exhaust demonstrating steady exhaust capability of τ He */τ E ∼3-10 in support of ITER. Suppression of neutral back flow and chemical sputtering effect have been observed while MARFE onset density is rather decreased. Negative-ion based neutral beam injection (N-NBI) experiments have created a clear H-mode transition. Enhanced ionization cross- section due to multi-step ionization processes was confirmed as theoretically predicted. A current density profile driven by N-NBI is measured in a good agreement with theoretical prediction. N-NBI induced TAE modes characterized as persistent and bursting oscillations have been observed from a low hot beta of h >∼0.1-0.2% without a significant loss of fast ions. (author)

  20. Cannabinoids assessment in plasma and urine by high performance liquid chromatography-tandem mass spectrometry after molecularly imprinted polymer microsolid-phase extraction.

    Science.gov (United States)

    Sánchez-González, Juan; Salgueiro-Fernández, Rocío; Cabarcos, Pamela; Bermejo, Ana María; Bermejo-Barrera, Pilar; Moreda-Piñeiro, Antonio

    2017-02-01

    A molecularly imprinted polymer (MIP) selective for cannabinoids [Δ 9 -tetrahydrocannabinol (Δ9-THC), 11-nor-9-carboxy-Δ 9 -tetrahydrocannabinol (Δ9-THC-COOH), and 11-hydroxy-Δ 9 -tetrahydrocannabinol (Δ9-THC-OH)] has been synthesized, fully characterized, and applied to the assessment of plasma and urine analysis of marijuana abuse by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Δ9-THC-COOH was used as a template molecule, whereas ethylene glycol dimethacrylate (EGDMA) was used as a functional monomer, divinylbenzene (DVB) as a cross-linker, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator. The prepared MIP was found to be highly selective for cannabinoids typically found in blood and urine, and also for cannabinol (CBN) and cannabidiol (CBD). MIP beads (50 mg) were loaded inside a cone-shaped device made of a polypropylene (PP) membrane for microsolid-phase extraction (μ-SPE) in batch mode. Optimum retention of analytes (0.1 to 1.0 mL of plasma/urine) was achieved by fixing plasma/urine pH at 6.5 and assisting the procedure by mechanical shaking (150 rpm, 40 °C, 12 min). Optimum elution conditions implied 2 mL of a 90:10 methanol/acetic acid and ultrasound extraction (35 kHz, 325 W) for 6 min. Good precision was assessed by intra-day and inter-day assays. In addition, the method was found to be accurate after intra-day and inter-day analytical recovery assays and after analyzing control serum and urine control samples. The limits of quantification were in the range of 0.36-0.49 ng L -1 (plasma analysis) and 0.47-0.57 ng L -1 (urine analysis). These values are low enough for confirmative conclusions regarding marijuana abuse through blood and urine analysis. Graphical Abstract ᅟ.

  1. Ultra-high-performance liquid chromatography tandem mass spectrometry determination of GHB, GHB-glucuronide in plasma and cerebrospinal fluid of narcoleptic patients under sodium oxybate treatment.

    Science.gov (United States)

    Tittarelli, Roberta; Pichini, Simona; Pedersen, Daniel S; Pacifici, Roberta; Moresco, Monica; Pizza, Fabio; Busardò, Francesco Paolo; Plazzi, Giuseppe

    2017-05-01

    Sodium oxybate (Xyrem ® ), the sodium salt of γ- hydroxybutyric acid (GHB), is a first-line treatment of the symptoms induced by type 1 narcolepsy (NT1) and it is highly effective in improving sleep architecture, decreasing excessive daytime sleepiness and the frequency of cataplexy attacks. Using an ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) validated method, GHB was determined together with its glucuronide (GHB-gluc), in plasma and cerebrospinal fluid (CSF) samples of NT1 patients under sodium oxybate treatment. To characterize the plasma pharmacokinetics of GHB, three subjects with NT1 were administered at time 0 and 4h with 1.25, 1.5 and 3.55g Xyrem ® , respectively and had their blood samples collected at 7 time points throughout an 8-h session. CSF specimens, collected for orexin A measurement from the same three subjects 6h after their second administration, were also tested. The results obtained suggested that GHB plasma values increased disproportionally with the rising doses, (C max0-4 : 12.53, 32.95 and 69.62μg/mL; C max4-8 : 44.93, 75.03 and 111.93μg/mL for total Xyrem ® dose of 2.5, 3 and 7g respectively) indicating non-linear dose-response. GHB-Gluc was present only in traces in all plasma samples from treated patients, not changing with increasing Xyrem ® doses. GHB values of 5.62, 6.10 and 17.74μg/mL for 2, 3 and 7g Xyrem ® were found in CSF with a significant difference from control values. GHB-Gluc was found in negligible concentrations with no differences to those of control individuals. In conclusion this simple and fast UHPLC-MS/MS method proved useful for pharmacokinetic studies and therapeutic drug monitoring of GHB in narcoleptic patients treated with sodium oxybate. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Bifurcation to Enhanced Performance H-mode on NSTX

    Science.gov (United States)

    Battaglia, D. J.; Chang, C. S.; Gerhardt, S. P.; Kaye, S. M.; Maingi, R.; Smith, D. R.

    2015-11-01

    The bifurcation from H-mode (H98 Performance (EP)H-mode (H98 = 1.2 - 2.0) on NSTX is found to occur when the ion thermal (χi) and momentum transport become decoupled from particle transport, such that the ion temperature (Ti) and rotation pedestals increase independent of the density pedestal. The onset of the EPH-mode transition is found to correlate with decreased pedestal collisionality (ν*ped) and an increased broadening of the density fluctuation (dn/n) spectrum in the pedestal as measured with beam emission spectroscopy. The spectrum broadening at decreased ν*ped is consistent with GEM simulations that indicate the toroidal mode number of the most unstable instability increases as ν*ped decreases. The lowest ν*ped, and thus largest spectrum broadening, is achieved with low pedestal density via lithium wall conditioning and when Zeff in the pedestal is significantly reduced via large edge rotation shear from external 3D fields or a large ELM. Kinetic neoclassical transport calculations (XGC0) confirm that Zeff is reduced when edge rotation braking leads to a more negative Er that shifts the impurity density profiles inward relative to the main ion density. These calculations also describe the role kinetic neoclassical and anomalous transport effects play in the decoupling of energy, momentum and particle transport at the bifurcation to EPH-mode. This work was sponsored by the U.S. Department of Energy.

  3. ELM suppression in low edge collisionality H-mode discharges using n = 3 magnetic perturbations

    Energy Technology Data Exchange (ETDEWEB)

    Burrell, K H [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Evans, T E [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Doyle, E J [University of California, Los Angeles, California (United States); Fenstermacher, M E [Lawrence Livermore National Laboratory, Livermore, California (United States); Groebner, R J [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Leonard, A W [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Moyer, R A [University of California, San Diego, California (United States); Osborne, T H; Schaffer, M J; Snyder, P B [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Thomas, P R [CEA Cadarache EURATOM Association, Cadarache (France); West, W P [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Boedo, J A [University of California, San Diego, California (United States); Garofalo, A M [Columbia University, New York, New York (United States); Gohil, P; Jackson, G L; La Haye, R J [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Lasnier, C J [Lawrence Livermore National Laboratory, Livermore, California (United States); Reimerdes, H [Columbia University, New York, New York (United States); Rhodes, T L [University of California, Los Angeles, California (United States); Scoville, J T [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Solomon, W M [Princeton Plasma Physics Laboratory, Princeton, New Jersey (United States); Thomas, D M [General Atomics, PO Box 85608, San Diego, CA 92186-9784 (United States); Wang, G [University of California, Los Angeles, California (United States); Watkins, J G [Sandia National Laboratories, Albuquerque, New Mexico (United States); Zeng, L [University of California, Los Angeles, California (United States)

    2005-12-15

    Using resonant magnetic perturbations with toroidal mode number n = 3, we have produced H-mode discharges without edge localized modes (ELMs) which run with constant density and radiated power for periods up to about 2550 ms (17 energy confinement times). These ELM suppression results are achieved at pedestal collisionalities close to those desired for next step burning plasma experiments such as ITER and provide a means of eliminating the rapid erosion of divertor components in such machines which could be caused by giant ELMs. The ELM suppression is due to an enhancement in the edge particle transport which reduces pedestal current density and maximum edge pressure gradient below the threshold for peeling-ballooning modes. These n = 3 magnetic perturbations provide a means of active control of edge plasma transport.

  4. ELM suppression in low edge collisionality H-mode discharges using n = 3 magnetic perturbations

    International Nuclear Information System (INIS)

    Burrell, K H; Evans, T E; Doyle, E J; Fenstermacher, M E; Groebner, R J; Leonard, A W; Moyer, R A; Osborne, T H; Schaffer, M J; Snyder, P B; Thomas, P R; West, W P; Boedo, J A; Garofalo, A M; Gohil, P; Jackson, G L; La Haye, R J; Lasnier, C J; Reimerdes, H; Rhodes, T L; Scoville, J T; Solomon, W M; Thomas, D M; Wang, G; Watkins, J G; Zeng, L

    2005-01-01

    Using resonant magnetic perturbations with toroidal mode number n = 3, we have produced H-mode discharges without edge localized modes (ELMs) which run with constant density and radiated power for periods up to about 2550 ms (17 energy confinement times). These ELM suppression results are achieved at pedestal collisionalities close to those desired for next step burning plasma experiments such as ITER and provide a means of eliminating the rapid erosion of divertor components in such machines which could be caused by giant ELMs. The ELM suppression is due to an enhancement in the edge particle transport which reduces pedestal current density and maximum edge pressure gradient below the threshold for peeling-ballooning modes. These n = 3 magnetic perturbations provide a means of active control of edge plasma transport

  5. Simultaneous quantitation of hydrazine and acetylhydrazine in human plasma by high performance liquid chromatography-tandem mass spectrometry after derivatization with p-tolualdehyde.

    Science.gov (United States)

    Song, Lu; Gao, Dan; Li, Shangfu; Wang, Yanwei; Liu, Hongxia; Jiang, Yuyang

    2017-09-15

    A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for simultaneous quantitative analysis of hydrazine and acetylhydrazine in human plasma based on the strategy of p-tolualdehyde derivatization. The derivatization reactions were easily realized by ultrasonic manipulation for 40min. Good separation of the derivatization products was achieved using a C 18 column by gradient elution. The optimized mass transition ion-pairs (m/z) monitored for the two hydrazine derivatives were m/z 237.1≫>119.9 and m/z 176.9≫>117.8, respectively. The limit of detection (LOD) and limit of quantification (LOQ) for hydrazine were 0.002 and 0.005ngmL -1 separately. And they were 0.03 and 0.05ngmL -1 for acetylhydrazine, respectively. The linear range was 0.005-50ngmL -1 for hydrazine and 0.05-500ngmL -1 for acetylhydrazine with R 2 greater than 0.999. The recovery range was determined to be 95.38-108.12% with the relative standard deviation (RSD) in the range of 1.24-14.89%. The method was successfully applied to detect 30 clinical plasma samples of pulmonary tuberculosis patients treated with isoniazid. The concentrations were from 0.04-1.99ngmL -1 for hydrazine and 0.06-142.43ngmL -1 for acetylhydrazine. The results indicated that our developed method had the potential for the detection of hydrazine toxicology in complex biological samples. Furthermore, the method has an important significance to clinical treatment with drugs. Copyright © 2017. Published by Elsevier B.V.

  6. Quantification of piperazine phosphate in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry employing precolumn derivatization with dansyl chloride.

    Science.gov (United States)

    Lin, Hui; Tian, Yuan; Zhang, Zunjian; Wu, Lili; Chen, Yun

    2010-04-01

    This paper describes a novel method that combines dansyl chloride (DNS-CL) derivatization with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS) for the sensitive and selective determination of piperazine phosphate in human plasma. After addition of ondansetron hydrochloride as internal standard (IS), piperazine phosphate was derivatized and then extracted with ethyl acetate. After being evaporated and reconstituted, the sample was analyzed using LC-ESI/MS/MS. Separation was achieved using an Agilent ZORBAX SB-C(18) (150 mm x 2.1 mm I.D., 3.5 microm) column and isocratic elution with 10 mM ammonium acetate solution (pH 3.0)-methanol (50: 50, v/v). Detection was performed on a triple-quadrupole mass spectrometer utilizing electrospray ionization (ESI) interface operating in positive ion and selected reaction monitoring (SRM) mode with the precursor to product ion transitions m/z 320-->171 for DNS-CL-piperazine phosphate and m/z 294-->170 for the IS. The method was fully validated for its selectivity, sensitivity, linearity, precision, accuracy, recovery, matrix effect and stability. The coefficient (r) of piperazine phosphate with a linear range of 0.1-15 microg mL(-1) was 0.9974-0.9995. The limit of detection and lower limit of quantification in human plasma were 0.01 and 0.1 microg mL(-1), respectively. The validated LC-ESI/MS/MS method has been successfully applied to a bioequivalence study of piperazine phosphate trochiscus in Chinese healthy male volunteers. 2010 Elsevier B.V. All rights reserved.

  7. Determination of rivaroxaban in patient's plasma samples by anti-Xa chromogenic test associated to High Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS).

    Science.gov (United States)

    Derogis, Priscilla Bento Matos; Sanches, Livia Rentas; de Aranda, Valdir Fernandes; Colombini, Marjorie Paris; Mangueira, Cristóvão Luis Pitangueira; Katz, Marcelo; Faulhaber, Adriana Caschera Leme; Mendes, Claudio Ernesto Albers; Ferreira, Carlos Eduardo Dos Santos; França, Carolina Nunes; Guerra, João Carlos de Campos

    2017-01-01

    Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure rivaroxaban plasmatic concentration. Our method used a simple sample preparation, protein precipitation, and a fast chromatographic run. It was developed a precise and accurate method, with a linear range from 2 to 500 ng/mL, and a lower limit of quantification of 4 pg on column. The new method was compared to a reference method (anti-factor Xa activity) and both presented a good correlation (r = 0.98, p plasma samples for rivaroxaban measurement by HPLC-MS/MS without interferences. The chromogenic and HPLC-MS/MS methods were highly correlated and should be used as clinical tools for drug monitoring. The method was applied successfully in a group of 49 real-life patients, which allowed an accurate determination of rivaroxaban in peak and trough levels.

  8. [Simultaneous determination of 7 arsenic species in chicken muscle and chicken liver with high performance liquid chromatography-inductively coupled plasma mass spectrometry].

    Science.gov (United States)

    Yang, Lijun; Hu, Qiaoru; Guo, Wei; Liu, Yumin; Song, Xiaohua; Zhang, Pengcheng

    2011-05-01

    A method for the simultaneous determination of 7 arsenic species was developed with high performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The sample was extracted with artificial gastric juice. The HPLC separation was performed on an anion analytical column utilizing a gradient elution program of ammonium carbonate and water as the mobile phase. Identification and quantification were achieved by ICP-MS. Good linearities of 7 arsenic species were observed in the range from 1 microg/kg to 50 microg/kg with the correlation coefficients greater than 0.999. The average recoveries of 7 arsenic species spiked at the three levels of 1, 2 and 10 microg/kg ranged from 84.3% to 106.6% with the relative standard deviations of 1.4%-4.2%. The quantification limits of 7 arsenic species were 1 microg/kg. The method was proved to be good reproducibility, high sensitivity and simple preprocessing. This method is suitable for the simultaneous determination of 7 arsenic species in chicken muscle and chicken liver.

  9. Speciation of mercury in water samples by dispersive liquid-liquid microextraction combined with high performance liquid chromatography-inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Jia Xiaoyu; Han Yi; Liu Xinli [State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Duan Taicheng, E-mail: tcduan@ciac.jl.cn [State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (China); Chen Hangting, E-mail: htchen@ciac.jl.cn [State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (China)

    2011-01-15

    The dispersive liquid-liquid microextraction (DLLME) combined with high performance liquid chromatography-inductively coupled plasma mass spectrometry for the speciation of mercury in water samples was described. Firstly methylmercury (MeHg{sup +}) and mercury (Hg{sup 2+}) were complexed with sodium diethyldithiocarbamate, and then the complexes were extracted into carbon tetrachloride by using DLLME. Under the optimized conditions, the enrichment factors of 138 and 350 for MeHg{sup +} and Hg{sup 2+} were obtained from only 5.00 mL sample solution. The detection limits of the analytes (as Hg) were 0.0076 ng mL{sup -1} for MeHg{sup +} and 0.0014 ng mL{sup -1} for Hg{sup 2+}, respectively. The relative standard deviations for ten replicate measurements of 0.5 ng mL{sup -1} MeHg{sup +} and Hg{sup 2+} were 6.9% and 4.4%, respectively. Standard reference material of seawater (GBW(E)080042) was analyzed to verify the accuracy of the method and the results were in good agreement with the certified values. Finally, the developed method was successfully applied for the speciation of mercury in three environmental water samples.

  10. Speciation Analysis of Trace Mercury in Sea Cucumber Species of Apostichopus japonicus Using High-Performance Liquid Chromatography Conjunction With Inductively Coupled Plasma Mass Spectrometry.

    Science.gov (United States)

    Liu, Hao; Luo, Jiaoyang; Ding, Tong; Gu, Shanyong; Yang, Shihai; Yang, Meihua

    2018-03-25

    In this paper, a simple and cost-effective method using high-performance liquid chromatography in conjunction with inductively coupled plasma mass spectrometry with a rapid ultrasound-assisted extraction was used for analysis speciation of trace mercury in sea cucumber species of Apostichopus japonicus. The effective separation of inorganic mercury, methylmercury, and ethylmercury was achieved within 10 min using Agilent ZORBAX SB-C 18 analytical and guard columns with an isocratic mobile phase consisting of 8% methanol and 92% H 2 O containing 0.12% L-cysteine (m/v) and 0.01 mol/L ammonium acetate. Mercury species were extracted from A. japonicus samples using a solution containing 2-mercaptoethanol, L-cysteine, and hydrochloric acid and sonicating for 0.5 h. The limits of detection of inorganic mercury, methylmercury, and ethylmercury were 0.12, 0.08, and 0.20 μg/L, and the minimum detectable concentrations (measured at 0.500 g sample volume in 10.00 mL) were 2.4, 1.6, and 4.0 μg/kg, respectively. Analysis of a scallop certified reference material (GBW 10024) revealed accordance between the experimental and certified values. This study provides a reference for the evaluation of mercury speciation in sea cucumber and other seafood.

  11. Determination of Tributyltin in Seafood Based on Magnetic Molecularly Imprinted Polymers Coupled with High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Hua Yang

    2017-01-01

    Full Text Available In this study, Fe3O4 was adopted as a carrier for surface molecular imprinting with two-stage polymerization. First, the functional monomer (methacrylic acid, MAA was modified on the surface of Fe3O4, which was then polymerized with the template molecule (tributyltin, TBT, cross linking agent (ethylene glycol dimethacrylate, EGDMA, and porogen (acetonitrile, hereby successfully preparing Fe3O4@MIPs prone to specifically identify TBT. The physical properties of Fe3O4@MIPs were then characterized, and adsorption and selection capacities were also assessed. Compared with conventional imprinting polymers, this magnetic molecular imprinting polymer (MIP displayed significantly increased and more specific adsorption. Meanwhile, its pretreatment was simpler and faster due to magnetic separation characteristics. Using magnetic MIPs as adsorbents for enrichment and separation, detection limit, recovery rate, and linear range were 1.0 ng g−1, 79.74–95.72%, and 5 ng g−1~1000 ng g−1, respectively, for a number of seafood samples. High-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS was used to analyze Tegillarca granosa, mussels, large yellow croaker, and other specimens, with recovery rates of 79.74–95.72% and RSD of 1.3%–4.7%. Overall, this method has a shorter total analysis time, lower detection limit, and wider linear range and can be more effectively applied to determine MAA in seawater and seafood.

  12. Simultaneous determination of plasma creatinine, uric acid, kynurenine and tryptophan by high-performance liquid chromatography: method validation and in application to the assessment of renal function.

    Science.gov (United States)

    Zhao, Jianxing

    2015-03-01

    A high-performance liquid chromatography with ultraviolet detection method has been developed for the simultaneous determination of a set of reliable markers of renal function, including creatinine, uric acid, kynurenine and tryptophan in plasma. Separation was achieved by an Agilent HC-C18 (2) analytical column. Gradient elution and programmed wavelength detection allowed the method to be used to analyze these compounds by just one injection. The total run time was 25 min with all peaks of interest being eluted within 13 min. Good linear responses were found with correlation coefficient >0.999 for all analytes within the concentration range of the relevant levels. The recovery was: creatinine, 101 ± 1%; uric acid, 94.9 ± 3.7%; kynurenine, 100 ± 2%; and tryptophan, 92.6 ± 2.9%. Coefficients of variation within-run and between-run of all analytes were ≤2.4%. The limit of detection of the method was: creatinine, 0.1 µmol/L; uric acid, 0.05 µmol/L; kynurenine, 0.02 µmol/L; and tryptophan, 1 µmol/L. The developed method could be employed as a useful tool for the detection of chronic kidney disease, even at an early stage. Copyright © 2014 John Wiley & Sons, Ltd.

  13. Ultra-high-performance liquid chromatography tandem mass spectrometry method for the determination of gambogenic acid in dog plasma and its application to a pharmacokinetic study.

    Science.gov (United States)

    Chen, Jin Pei; Wang, Dian Lei; Yang, Li Li; Wang, Chen Yin; Wang, Shan Shan

    2014-12-01

    A highly sensitive and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of gambogenic acid in dog plasma. Gambogic acid was used as an internal standard (IS). After a simple liquid-liquid extraction by ethyl acetate, the analyte and internal standard were separated on an Acquity BEH C18 (100 × 2.1 mm, 1.7 µm; Waters ) column at a flow rate of 0.2 mL/min, using 0.1% formic acid-methanol (10:90, v/v) as mobile phase. Electrospray ionization source was applied and operated in the positive ion mode. Multiple reaction monitoring mode with the transitions m/z 631.3 → 507.3 and m/z 629.1 → 573.2 was used to quantify gambogenic acid and the internal standard, respectively. The calibration curves were linear in the range of 5-1000 ng/mL, with a coefficient of determination (r) of 0.999 and good calculated accuracy and precision. The low limit of quantification was 5 ng/mL. The intra-and inter-day precisions (relative standard deviations) were dogs at a dose of 1 mg/kg. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Elemental speciation via high-performance liquid chromatography combined with inductively coupled plasma atomic emission spectroscopic detection: application of a direct injection nebulizer

    International Nuclear Information System (INIS)

    LaFreniere, K.E; Fassel, V.A.; Eckels, D.E.

    1987-01-01

    An evaluation is presented of a direct injection nebulizer (DIN) interfaced to a high-performance liquid chromatograph (HPLC) with inductively coupled plasma atomic emission spectroscopic (ICP-AES) detection for simultaneous multielement speciation. The limits of detection (LODs) obtained with the DIN interface in the HPLC mode were found to be comparable to those obtained by continuous-flow sample introduction into the ICP, or inferior by up to only a factor of 4. In addition, the DIN allowed for the direct injection into the ICP of a variety of common HPLC solvents (up to 100% methanol, acetonitrile, methyl isobutyl ketone, pyridine, and water). The HPLC-DIN-ICP-AES system was compared to other HPLC-atomic spectroscopic detection techniques and was found to offer substantial improvement over the alternative on-line, detection methods in terms of LODs. Representative applications of the HPLC-DIN-ICP-AES system to the elemental speciation of coal process streams, shale oil, solvent refined coal, and crude oil are presented

  15. Simultaneous determination of vinclozolin and detection of its degradation products in mouse plasma, serum and urine, and from rabbit bile, by high-performance liquid chromatography.

    Science.gov (United States)

    Dhananjeyan, Mugunthu R; Erhardt, Paul W; Corbitt, Cynthia

    2006-05-19

    A specific high-performance liquid chromatography method has been developed for simultaneous detection of vinclozolin and its degradation products (M1, M2, and M3). The method has been validated according to ICH guidelines and can be extended to quantitation of vinclozolin. A base-line separation of vinclozolin and its degradation products was found with symmetrical peak shapes on an XTerra MS C18 column using 10 mM ammonium bicarbonate at pH 9.2 and acetonitrile as mobile phase. The retention times of vinclozolin, M1, M2, and M3 were 12.8, 8.1, 11.6, and 11.1 min, respectively. A linear calibration curve was obtained across a range from 5 to 200 microM for vinclozolin. The intra- and inter-day relative standard deviations (%RSD) were vinclozolin from bio-fluids including mouse plasma, serum and urine, and rabbit bile, were obtained in a single step with a single solvent.

  16. Method development for speciation analysis of nanoparticle and ionic forms of gold in biological samples by high performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry

    Science.gov (United States)

    Malejko, Julita; Świerżewska, Natalia; Bajguz, Andrzej; Godlewska-Żyłkiewicz, Beata

    2018-04-01

    A new method based on coupling high performance liquid chromatography (HPLC) to inductively coupled plasma mass spectrometry (ICP MS) has been developed for the speciation analysis of gold nanoparticles (AuNPs) and dissolved gold species (Au(III)) in biological samples. The column type, the composition and the flow rate of the mobile phase were carefully investigated in order to optimize the separation conditions. The usefulness of two polymeric reversed phase columns (PLRP-S with 100 nm and 400 nm pore size) to separate gold species were investigated for the first time. Under the optimal conditions (PLRP-S400 column, 10 mmol L-1 SDS and 5% methanol as the mobile phase, 0.5 mL min-1 flow rate), detection limits of 2.2 ng L-1 for Au(III), 2.8 ng L-1 for 10 nm AuNPs and 3.7 ng L-1 for 40 nm AuNPs were achieved. The accuracy of the method was proved by analysis of reference material RM 8011 (NIST) of gold nanoparticles of nominal diameter of 10 nm. The HPLC-ICP MS method has been successfully applied to the detection and size characterization of gold species in lysates of green algae Acutodesmus obliquus, typical representative of phytoplankton flora, incubated with 10 nm AuNPs or Au(III).

  17. Arsenic Species in Edible Seaweeds Using In Vitro Biomimetic Digestion Determined by High-Performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Yan-Fang Zhao

    2014-01-01

    Full Text Available Arsenite [As (III], arsenate [As (V], methylarsonate (MMA, and dimethylarsinate (DMA in five edible seaweeds (the brown algae Laminaria japonica, red algae Porphyra yezoensis, brown algae Undaria pinnatifida, brown algae Hizikia fusiformis, and green algae Enteromorpha prolifera were analyzed using in vitro digestion method determined by high-performance liquid chromatography inductively coupled plasma mass spectrometry. The results showed that DMA was found in the water extracts of all samples; As (III were detected in L. japonica and U. pinnatifida and about 23.0 and 0.15 mg/kg of As (V were found in H. fusiformis and E. prolifera respectively. However, after the gastrointestinal digestion, As (V was not detected in any of the five seaweeds. About 0.19 and 1.47 mg/kg of As (III was detected in the gastric extracts of L. japonica and H. fusiformis, respectively, and about 0.31 and 0.10 mg/kg of As (III were extracted from the intestinal extracts of Porphyra yezoensis and U. pinnatifida, respectively. The present results successfully reveal the differences of As species and levels in the water and biomimetic extracts of five edible seaweeds. The risk assessment of the inorganic arsenic in the five edible seaweeds based on present data showed almost no hazards to human health.

  18. Speciation of mercury in water samples by dispersive liquid-liquid microextraction combined with high performance liquid chromatography-inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Jia Xiaoyu; Han Yi; Liu Xinli; Duan Taicheng; Chen Hangting

    2011-01-01

    The dispersive liquid-liquid microextraction (DLLME) combined with high performance liquid chromatography-inductively coupled plasma mass spectrometry for the speciation of mercury in water samples was described. Firstly methylmercury (MeHg + ) and mercury (Hg 2+ ) were complexed with sodium diethyldithiocarbamate, and then the complexes were extracted into carbon tetrachloride by using DLLME. Under the optimized conditions, the enrichment factors of 138 and 350 for MeHg + and Hg 2+ were obtained from only 5.00 mL sample solution. The detection limits of the analytes (as Hg) were 0.0076 ng mL -1 for MeHg + and 0.0014 ng mL -1 for Hg 2+ , respectively. The relative standard deviations for ten replicate measurements of 0.5 ng mL -1 MeHg + and Hg 2+ were 6.9% and 4.4%, respectively. Standard reference material of seawater (GBW(E)080042) was analyzed to verify the accuracy of the method and the results were in good agreement with the certified values. Finally, the developed method was successfully applied for the speciation of mercury in three environmental water samples.

  19. Evaluation of Particle Pinch and Diffusion Coefficients in the Edge Pedestal of DIII-D H-mode Discharges

    Science.gov (United States)

    Stacey, W. M.; Groebner, R. J.

    2009-11-01

    Momentum balance requires that the radial particle flux satisfy a pinch-diffusion relationship. The pinch can be evaluated in terms of measurable quantities (rotation velocities, Er, etc.) by the use of momentum and particle balance [1,2], the radial particle flux can be determined by momentum balance, and then the diffusion coefficient can be evaluated from the pinch diffusion relation using the measured density gradient. Applications to several DIII-D H-mode plasmas are presented. 6pt [1] W.M. Stacey, Contr. Plasma Phys. 48, 94 (2008). [2] W.M. Stacey and R.J. Groebner, Phys. Plasmas 15, 012503 (2008).

  20. Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography: Mass spectrometry (UPLC/MS

    Directory of Open Access Journals (Sweden)

    Ćirić Biljana

    2010-01-01

    Full Text Available Background/Aim. Quantitative analysis of amoxicillin and clavulanic acid in biological matrices requires sensitive and specific methods which allow determination of therapeutic concentration in μg/mL range. Analytical methods for determination of their concentrations in body fluids described in literature include high performance liquid chromatography coupled to UV detector (HPLC-UV and liquid chromatography-mass spectrometry (LC-MS. The aim of this study was to develop sensitive and specific ultra performance liquid chromatography/ mass spectrometry (UPLC/MS method which could be used for the spectral identification and quantification of the low concentrations of amoxicillin and clavulanic acid in the human plasma. Method. A sensitive and specific UPLC/MS method for amoxicillin and clavulanic acid determination was developed in this study. The samples were taken from the adult healthy volunteers receiving per os one tablet of amoxicillin (875 mg in combination with clavulanic acid (125 mg. Results. Plasma samples were pretreated by direct deproteinization with perchloric acid. Quantification limit of 0.01 μg/ml for both amoxicillin and clavulanic acid was achieved. The method was reproducible day by day (RSD < 7 %. Analytical recoveries for amoxicillin ranged from 98.82% to 100.9% (for concentrations of 1, 5 and 20 μg/mL, and recoveries for clavulanic acid were 99,89% to 100.1% (for concentrations of 1, 2 and 5 μg/mL. This assay was successfully applied to a pilot pharmacokinetic study in healthy volunteers after a single-oral administration of amoxicillin/ clavulanic combination. The determined plasma concentrations of both amoxicillin and clavulanic acid were in the range of the expected values upon the literature data for HPLC-UV and LC-MS methods. Conclusion. The described method provided a few advantages comparing with LC/MS-MS method. The method is faster using running time of 5 minute, has lower limit of quantification (LOQ and it

  1. Chiral high-performance liquid chromatographic analysis of fluoxetine and norfluoxetine in rabbit plasma, urine, and vitreous humor using an acetylated beta-cyclodextrin column.

    Science.gov (United States)

    Yee, L; Wong, S H; Skrinska, V A

    2000-10-01

    Fluoxetine (Prozac) is a potent selective serotonin reuptake inhibitor used for the treatment of major depression. Both fluoxetine (F) and its demethylated metabolite, norfluoxetine (NF), are racemic. S-Fluoxetine (SF) and S-norfluoxetine (SNF) are more potent inhibitors of serotonin reuptake than R-fluoxetine (RF) and R-norfluoxetine (RNF). Quantitation of individual enantiomers may provide a greater understanding of pharmacokinetic properties. The objective of this study was to perform a limited chiral selectivity study using rabbit plasma, urine, and vitreous humor analyzed by a solid-phase extraction protocol and a newly developed chiral analysis with an acetylated beta-cyclodextrin (CD) column. Liquid chromatographic parameters for CD were as follows: a mobile phase composition of methanol/0.3% triethylamine buffer, pH 5.6, (30:70), a flow rate of 1 mL/min, detection at 214 nm, and a temperature of 40 degrees C. Elution order was SNF, SF, RNF, and RF with capacity factors of 6, 7, 8, and 9, respectively. The corresponding resolution factors were as follows: R1,2 = 0.8, R2,3 = 1.2, and R3,4 = 0.9. The conditions for solid-phase extraction were optimized for Varian Bond Elut Certify columns. Following sample application, the column was rinsed with water, acetic acid, and then with methanol. Drug enantiomers were eluted with methylene chloride, isopropanol, and ammonium hydroxide (78:20:2). After extract evaporation, the extract residue was reconstituted for high-performance liquid chromatographic analysis. To investigate chiral pharmacology, a biodistribution study was performed by administering 2 mg/kg of F to five rabbits. Blood, urine, and vitreous specimens were collected. Plasma samples collected 45 min postinjection showed nearly equal concentrations of RF and SE After 24 h, the only metabolite detected in plasma was RNF. Drugs were not detectable in vitreous humor. Urine concentrations of SNF, SF, RNF, and RF were 51, 76, 34, and 8 microg/L, respectively

  2. Development and validation of a chiral high-performance liquid chromatography assay for rogletimide and rogletimide-N-oxide isomers in plasma.

    Science.gov (United States)

    Etienne, M C; Oster, W; Milano, G

    1996-01-01

    The purpose of the present study was to develop and validate a stereo-specific high-performance liquid chromatography (HPLC) assay for rogletimide (Rog) and rogletimide-N-oxide (Nox) isomers in plasma. The assay was performed with a chiral cellulose-[4-methylbenzoate]ester column (Chiracel OJ). Optimal separation was achieved isocratically with a mobile phase consisting of n-hexane/anhydrous ethanol (65/35, v/v) at a flow rate of 0.9 ml/min, with the column being thermostated at +35 degrees C (UV detection at 257 nm). Under these conditions, retention times were approximately 17, 28, 31 and 76 min for R-Rog, S-Rog, R-Nox and S-Nox, respectively. S-aminoglutethimide (S-Ag) served as the internal standard (retention time 70 min). An extraction procedure from plasma samples was developed on Bond Elut RP8 500-mg cartridges; conditioning was performed with 5 ml methanol and 5 ml water, after which 1 ml plasma that had previously been spiked with 5 microM S-Ag was applied. Washing was done with 6 ml water and elution, with 4 ml methanol. After evaporation to dryness, residues were dissolved in 400 microliters anhydrous ethanol and 12-48 microliters was injected onto the HPLC system. Blank plasma from healthy donors showed the random presence of a small interference eluting at the retention time of R-Rog, precluding the accurate quantification of R-Rog concentrations below 2.5 microM. Reproducibility assays demonstrated the need to use an internal standard. Taking into account the internal standard, at 2.5 microM the intra- and inter-assay coefficients of variation were 10.5% and 21.0% for R-Rog 5.5% and 8.7% for S-Rog, 7.6% and 20.8% for R-Nox and 11.7% and 6.4% for S-Nox, respectively. The detection limit was 2.5 microM for R-Rog, 0.5 microM for S-Rog, 0.25 microM for R-Nox and 0.5 microM for S-Nox. Linearity was satisfactory at concentrations ranging from 2.5 to 10 microM for R-Rog, from 0.5 to 10 microM for S-Rog, from 0.25 to 2.5 microM for R-Nox and from 0.50 to 2

  3. Fuel ion rotation measurement and its implications on H-mode theories

    International Nuclear Information System (INIS)

    Kim, J.; Burrell, K.H.; Gohil, P.; Groebner, R.J.; Hinton, F.L.; Kim, Y.B.; Seraydarian, R.; Mandl, W.

    1993-10-01

    Poloidal and toroidal rotation of the fuel ions (He 2+ ) and the impurity ions (C 6+ and B 5+ ) in H-mode helium plasmas have been investigated in the DIII-D tokamak by means of charge exchange recombination spectroscopy, resulting in the discovery that the fuel ion poloidal rotation is in the ion diamagnetic drift direction while the impurity ion rotation is in the electron diamagnetic drift direction. The radial electric field obtained from radial force balance analysis of the measured pressure gradients and rotation velocities is shown to be the same regardless of which ion species is used and therefore is a more fundamental parameter than the rotation flows in studying H-mode phenomena. It is shown that the three contributions to the radial electric field (diamagnetic, poloidal rotation, and toroidal rotation terms) are comparable and consequently the poloidal flow does not solely represent the E x B flow. In the high-shear edge region, the density scale length is comparable to the ion poloidal gyroradius, and thus neoclassical theory is not valid there. In view of this new discovery that the fuel and impurity ions rotate in opposite sense, L-H transition theories based on the poloidal rotation may require improvement

  4. Study of H-mode threshold conditions in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Carlstrom, T.N.; Burrell, K.H.

    1996-10-01

    Studies have been conducted in DIII-D to determine the dependence of the power threshold P lh for the transition to the H-mode regime and the threshold P hl for the transition from H-mode to L-mode as functions of external parameters. There is a value of the line-averaged density n e at which P lh has a minimum and P lh tends to increase for lower and higher values of n e . Experiments conducted to separate the effect of the neutral density n 0 from the plasma density n e give evidence of a strong coupling between n 0 and n e . The separate effect of neutrals on the transition has not been determined. Coordinated experiments with JET made in the ITER shape show that P lh increases approximately as S 0.5 where S is the plasma surface area. For these discharges, the power threshold in DIII-D was high by normal standards, thus suggesting that effects other than plasma size may have affected the experiment. Studies of H-L transitions have been initiated and hysteresis of order 40% has been observed. Studies have also been done of the dependence of the L-H transition on local edge parameters. Characterization of the edge within a few ms prior to the transition shows that the range of edge temperatures at which the transition has been observed is more restrictive than the range of densities at which it occurs. These results suggest that some temperature function is important for controlling the transition

  5. Rapid determination of retinoic acid and its main isomers in plasma by second-order high-performance liquid chromatography data modeling.

    Science.gov (United States)

    Teglia, Carla M; Cámara, María S; Goicoechea, Héctor C

    2014-12-01

    This paper reports the development of a method based on high-performance liquid chromatography (HPLC) coupled to second-order data modeling with multivariate curve resolution-alternating least-squares (MCR-ALS) for quantification of retinoic acid and its main isomers in plasma in only 5.5 min. The compounds retinoic acid (RA), 13-cis-retinoic acid, 9-cis-retinoic acid, and 9,13-di-cis-retinoic acid were partially separated by use of a Poroshell 120 EC-C18 (3.0 mm × 30 mm, 2.7 μm particle size) column. Overlapping not only among the target analytes but also with the plasma interferents was resolved by exploiting the second-order advantage of the multi-way calibration. A validation study led to the following results: trueness with recoveries of 98.5-105.9 % for RA, 95.7-110.1 % for 13-cis-RA, 97.1-110.8 % for 9-cis-RA, and 99.5-110.9 % for 9,13-di-cis-RA; repeatability with RSD of 3.5-3.1 % for RA, 3.5-1.5 % for 13-cis-RA, 4.6-2.7 % for 9-cis-RA, and 5.2-2.7 % for 9,13-di-cis-RA (low and high levels); and intermediate precision (inter-day precision) with RSD of 3.8-3.0 % for RA, 2.9-2.4 % for 13-cis-RA, 3.6-3.2 % for 9,13-di-cis-RA, and 3.2-2.9 % for 9-cis-RA (low and high levels). In addition, a robustness study revealed the method was suitable for monitoring patients with dermatological diseases treated with pharmaceutical products containing RA and 13-cis-RA.

  6. HIGH PERFORMANCE ADVANCED TOKAMAK REGIMES FOR NEXT-STEP EXPERIMENTS

    International Nuclear Information System (INIS)

    GREENFIELD, C.M.; MURAKAMI, M.; FERRON, J.R.; WADE, M.R.; LUCE, T.C.; PETTY, C.C.; MENARD, J.E; PETRIE, T.W.; ALLEN, S.L.; BURRELL, K.H.; CASPER, T.A; DeBOO, J.C.; DOYLE, E.J.; GAROFALO, A.M; GORELOV, Y.A; GROEBNER, R.J.; HOBIRK, J.; HYATT, A.W; JAYAKUMAR, R.J; KESSEL, C.E; LA HAYE, R.J; JACKSON, G.L; LOHR, J.; MAKOWSKI, M.A.; PINSKER, R.I.; POLITZER, P.A.; PRATER, R.; STRAIT, E.J.; TAYLOR, T.S; WEST, W.P.

    2003-01-01

    OAK-B135 Advanced Tokamak (AT) research in DIII-D seeks to provide a scientific basis for steady-state high performance operation in future devices. These regimes require high toroidal beta to maximize fusion output and poloidal beta to maximize the self-driven bootstrap current. Achieving these conditions requires integrated, simultaneous control of the current and pressure profiles, and active magnetohydrodynamic (MHD) stability control. The building blocks for AT operation are in hand. Resistive wall mode stabilization via plasma rotation and active feedback with non-axisymmetric coils allows routine operation above the no-wall beta limit. Neoclassical tearing modes are stabilized by active feedback control of localized electron cyclotron current drive (ECCD). Plasma shaping and profile control provide further improvements. Under these conditions, bootstrap supplies most of the current. Steady-state operation requires replacing the remaining Ohmic current, mostly located near the half-radius, with noninductive external sources. In DIII-D this current is provided by ECCD, and nearly stationary AT discharges have been sustained with little remaining Ohmic current. Fast wave current drive is being developed to control the central magnetic shear. Density control, with divertor cryopumps, of AT discharges with edge localized moding (ELMing) H-mode edges facilitates high current drive efficiency at reactor relevant collisionalities. A sophisticated plasma control system allows integrated control of these elements. Close coupling between modeling and experiment is key to understanding the separate elements, their complex nonlinear interactions, and their integration into self-consistent high performance scenarios. Progress on this development, and its implications for next-step devices, will be illustrated by results of recent experiment and simulation efforts

  7. Speciation of Selenium in Selenium-Enriched Sunflower Oil by High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry/Electrospray-Orbitrap Tandem Mass Spectrometry.

    Science.gov (United States)

    Bierla, Katarzyna; Flis-Borsuk, Anna; Suchocki, Piotr; Szpunar, Joanna; Lobinski, Ryszard

    2016-06-22

    The reaction of sunflower oil with selenite produces a complex mixture of selenitriglycerides with antioxidant and anticancer properties. To obtain insight into the identity and characteristics of the species formed, an analytical approach based on the combination of high-performance liquid chromatography (HPLC) with (78)Se-specific selenium detection by inductively coupled plasma mass spectrometry (ICP MS) and high-resolution (100 000), high mass accuracy (HPLC-ICP MS for the separation of a complex mixture of selenospecies and a mathematical correction of the background signal was developed. The identical chromatographic conditions served for the sample introduction into electrospray MS. Two types of samples were analyzed: sunflower oil dissolved in isopropanol and methanol extract of the oil containing 65% selenium. HPLC-ICP MS showed 14 peaks, 11 of which could also be detected in the methanol extract. Isotopic patterns corresponding to molecules with one or two selenium atoms could be attributed by Orbitrap MS at the retention times corresponding to the HPLC-ICP MS peak apexes. Structural data for these species were acquired by MS(2) and MS(3) fragmentation of protonated or sodiated ions using high-energy collisional dissociation (HCD). A total of 11 selenium-containing triglycerol derivatives resulting from the oxidation of one or two double bonds of linoleic acid and analogous derivatives of glycerol-mixed linoleate(s)/oleinate(s) have been identified for the first time. The presence of these species was confirmed by the targeted analysis in the total oil isopropanol solution. Their identification corroborated the predicted elution order in reversed-phase chromatography: LLL (glycerol trilinoleate), LLO (glycerol dilinoleate-oleinate), LOO (glycerol linoleate-dioleinate), OOO (glycerol trioleinate), of which the extrapolation allowed for the prediction of the identity [glycerol dioleinate-stearate (OOS) and glycerol oleinate-distearate (OSS)] of the

  8. Determination of tetrabromobisphenol-A/S and their main derivatives in water samples by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry.

    Science.gov (United States)

    Liu, Lihong; Liu, Aifeng; Zhang, Qinghua; Shi, Jianbo; He, Bin; Yun, Zhaojun; Jiang, Guibin

    2017-05-12

    As the most widely used brominated flame retardants (BFRs), Tetrabromobisphenol-A (TBBPA) as well as its alternative Tetrabromobisphenol-S (TBBPS) and their derivatives have raised wide concerns due to their adverse effects on human health and hence the sensitive detection of those BFRs was urgently needed. Herein, a novel analytical method based on high-performance liquid chromatography (HPLC) coupled with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) has been developed for the determination of TBBPA/S and their derivatives, including TBBPA-bis(2-hydroxyethyl ether) (TBBPA-BHEE), TBBPA-bis(allylether) (TBBPA-BAE), TBBPA-bis(glycidyl ether) (TBBPA-BGE), TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) and TBBPS-bis(2,3-dibromopropyl ether) (TBBPS-BDBPE) in water samples. After optimization, the TBBPA/S and their derivatives, especially the TBBPA-BAE and TBBPA-BDBPE were simultaneously and sensitively quantified by determination of bromine (m/z=79) by using the ICP-MS. The instrument limits of detection (LODs) for the TBBPA, TBBPA-BHEE, TBBPA-BGE, TBBPA-BAE, TBBPA-BDBPE, TBBPS and TBBPS-BDBPE were determined to be 0.12, 0.14, 0.19, 0.14, 0.12, 0.17 and 0.13μgL -1 , respectively, which was close to or much better than the reported methods. The relative standard deviations (RSDs, n=5) of peak area and retention time were better than 2.2% and 0.2% for intra-day analysis, indicating good repeatability and high precision. The proposed method had been successfully applied for the analysis of TBBPA/S and their derivatives in water samples with satisfactory recoveries (67.7%-113%). Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Arsenic species determination in human scalp hair by pressurized hot water extraction and high performance liquid chromatography-inductively coupled plasma-mass spectrometry.

    Science.gov (United States)

    Morado Piñeiro, Andrés; Moreda-Piñeiro, Jorge; Alonso-Rodríguez, Elia; López-Mahía, Purificación; Muniategui-Lorenzo, Soledad; Prada-Rodríguez, Darío

    2013-02-15

    Analytical methods for the determination of total arsenic and arsenic species (mainly As(III) and As(V)) in human scalp hair have been developed. Inductively coupled plasma-mass spectrometry (ICP-MS) and high performance liquid chromatography (HPLC) coupled to ICP-MS have been used for total arsenic and arsenic species determination, respectively. The proposed methods include a "green", fast, high efficient and automated species leaching procedure by pressurized hot water extraction (PHWE). The operating parameters for PHWE including modifier concentration, extraction temperature, static time, extraction steps, pressure, mean particle size, diatomaceous earth (DE) mass/sample mass ratio and flush volume were studied using design of experiments (Plackett-Burman design PBD). Optimum condition implies a modifier concentration (acetic acid) of 150 mM and powdered hair samples fully mixed with diatomaceous earth (DE) as a dispersing agent at a DE mass/sample mass ratio of 5. The extraction has been carried out at 100°C and at an extraction pressure of 1500 psi for 5 min in four extraction step. Under optimised conditions, limits of quantification of 7.0, 6.3 and 50.3 ng g(-1) for total As, As(III) and As(V), respectively were achieved. Repeatability of the overall procedure (4.4, 7.2 and 2.1% for total As, As(III) and As(V), respectively) was achieved. The analysis of GBW-07601 (human hair) certified reference material was used for validation. The optimised method has been finally applied to several human scalp hair samples. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. A plasma metabonomic analysis on potential biomarker in pyrexia induced by three methods using ultra high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Liu, Ting; Li, Songhe; Tian, Xiumin; Li, Zhaoqin; Cui, Yue; Han, Fei; Zhao, Yunli; Yu, Zhiguo

    2017-09-15

    Pyrexia usually is a systemic pathological process that can lead to metabolic disorders. Metabonomics as a powerful tool not only can reveal the pathological mechanisms, but also can give insight into the progression of pyrexia from another angle. Thus, an ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) metabonomic approach was employed for the first time to investigate the plasma biochemical characteristics of pyrexia induced by three methods and to reveal subtle metabolic changes under the condition of pyrexia so as to explore its mechanism. The acquired metabolic data of the models were subjected to principal component analysis (PCA) for allowing the clear separation of the pyrexia rats from the control rats. Variable importance for project values (VIP) and Student's t-test were used to screen the significant metabolic changes caused by pyrexia. Fifty-two endogenous metabolites were identified and putatively identified as potential biomarkers primarily associated with phospholipid metabolism, sphingolipid metabolism, fatty acid oxidation metabolism, fatty acid amides metabolism and amino acid metabolism, and related to bile acid biosynthesis and glycerolipid catabolism. LysoPC (14:0), LysoPC (18:3), LysoPC (20:4), LysoPC (16:0), phytosphingosine, Cer (d18:0/12:0), N-[(4E,8E)-1,3-dihydroxyoctadeca-4,8-dien-2-yl]hexadecanamide, oleamide, fatty acid amide C22:1, tryptophan, acetylcarnitine, palmitoylcarnitine and stearoylcarnitine were considered as common potential biomarkers of pyrexia rats induced by three methods: Our results revealed that the UHPLC-FT-ICR-MS-based metabolomic method is helpful for finding new potential metabolic markers for pyrexia detection and offers a good perspective in pyrexia research. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Low-loss interference filter arrays made by plasma-assisted reactive magnetron sputtering (PARMS) for high-performance multispectral imaging

    Science.gov (United States)

    Broßmann, Jan; Best, Thorsten; Bauer, Thomas; Jakobs, Stefan; Eisenhammer, Thomas

    2016-10-01

    Optical remote sensing of the earth from air and space typically utilizes several channels in the visible and near infrared spectrum. Thin-film optical interference filters, mostly of narrow bandpass type, are applied to select these channels. The filters are arranged in filter wheels, arrays of discrete stripe filters mounted in frames, or patterned arrays on a monolithic substrate. Such multi-channel filter assemblies can be mounted close to the detector, which allows a compact and lightweight camera design. Recent progress in image resolution and sensor sensitivity requires improvements of the optical filter performance. Higher demands placed on blocking in the UV and NIR and in between the spectral channels, in-band transmission and filter edge steepness as well as scattering lead to more complex filter coatings with thicknesses in the range of 10 - 25μm. Technological limits of the conventionally used ion-assisted evaporation process (IAD) can be overcome only by more precise and higher-energetic coating technologies like plasma-assisted reactive magnetron sputtering (PARMS) in combination with optical broadband monitoring. Optics Balzers has developed a photolithographic patterning process for coating thicknesses up to 15μm that is fully compatible with the advanced PARMS coating technology. This provides the possibility of depositing multiple complex high-performance filters on a monolithic substrate. We present an overview of the performance of recently developed filters with improved spectral performance designed for both monolithic filter-arrays and stripe filters mounted in frames. The pros and cons as well as the resulting limits of the filter designs for both configurations are discussed.

  12. Simultaneous quantification of flavonoids in blood plasma by a high-performance liquid chromatography method after oral administration of Blumea balsamifera leaf extracts in rats.

    Science.gov (United States)

    Nessa, Fazilatun; Ismail, Zhari; Mohamed, Nornisah; Karupiah, Sundram

    2013-03-01

    The leaves of Blumea balsamifera are used as a folk medicine in kidney stone diseases in South-East Asia. Phytochemical investigation revealed leaves contained a number of flavonoids. In view of these, the present work was aimed to quantify and preliminary pharmacokinetic investigation of five flavonoids viz. dihydroquercetin-7,4¢-dimethyl ether (I), dihydroquercetin-4¢-methyl ether (II), 5,7,3¢,5¢-tetrahydroxyflavanone (III), blumeatin (IV) and quercetin (V) in rat plasma following oral administration (0.5g/Kg) of B. balsamifera leaf extract in rats. Quantification was achieved by using a validated, reproducible high-performance liquid chromatographic method. The mean recoveries of I, II, III, IV and V were 90.6, 93.4, 93.5, 91.2 and 90.3% respectively. The limit of quantification was 25 ng/mL for I and IV, 10 ng/mL for II and III and 100 ng/mL for V respectively. The within day and day-to-day precision for all the compounds were HPLC method herein was applied for pharmacokinetic studies and the main pharmacokinetic parameters were: t1/2 (hr) 5.8, 4.3, 2.9, 5.7 and 7.3, Cmax (ng/mL) 594.9, 1542.9 1659.9, 208.9 and 3040.4; Tmax (hr) 4.7, 1.0, 1.0, 3.5 and 2.3; AUC0-oo (ng hr/mL) 5040, 5893, 9260, 1064 and 27233 for I, II, III, IV and V respectively. The developed method was suitable for pharmacokinetic studies and this preliminary study also revealed significant absorption after oral dosing in rats.

  13. Pedestal structure and stability in H-mode and I-mode: a comparative study on Alcator C-Mod

    International Nuclear Information System (INIS)

    Hughes, J.W.; Walk, J.R.; Davis, E.M.; LaBombard, B.; Baek, S.G.; Churchill, R.M.; Greenwald, M.; Hubbard, A.E.; Lipschultz, B.; Marmar, E.S.; Reinke, M.L.; Rice, J.E.; Theiler, C.; Terry, J.; White, A.E.; Whyte, D.G.; Snyder, P.B.; Groebner, R.J.; Osborne, T.; Diallo, A.

    2013-01-01

    New experimental data from the Alcator C-Mod tokamak are used to benchmark predictive modelling of the edge pedestal in various high-confinement regimes, contributing to greater confidence in projection of pedestal height and width in ITER and reactors. ELMy H-modes operate near stability limits for ideal peeling–ballooning modes, as shown by calculations with the ELITE code. Experimental pedestal width in ELMy H-mode scales as the square root of β pol at the pedestal top, i.e. the dependence expected from theory if kinetic ballooning modes (KBMs) were responsible for limiting the pedestal width. A search for KBMs in experiment has revealed a short-wavelength electromagnetic fluctuation in the pedestal that is a candidate driver for inter-edge localized mode (ELM) pedestal regulation. A predictive pedestal model (EPED) has been tested on an extended set of ELMy H-modes from C-Mod, reproducing pedestal height and width reasonably well across the data set, and extending the tested range of EPED to the highest absolute pressures available on any existing tokamak and to within a factor of three of the pedestal pressure targeted for ITER. In addition, C-Mod offers access to two regimes, enhanced D-alpha (EDA) H-mode and I-mode, that have high pedestals, but in which large ELM activity is naturally suppressed and, instead, particle and impurity transport are regulated continuously. Pedestals of EDA H-mode and I-mode discharges are found to be ideal magnetohydrodynamic (MHD) stable with ELITE, consistent with the general absence of ELM activity. Invocation of alternative physics mechanisms may be required to make EPED-like predictions of pedestals in these kinds of intrinsically ELM-suppressed regimes, which would be very beneficial to operation in burning plasma devices. (paper)

  14. Physics of the L-mode to H-mode transition in tokamaks

    International Nuclear Information System (INIS)

    Burrell, K.H.; Carlstrom, T.N.; Gohil, P.; Groebner, R.J.; Kim, J.; Osborne, T.H.; St. John, H.; Stambaugh, R.D.; Doyle, E.J.; Moyer, R.A.; Rettig, C.L.; Peebles, W.A.; Rhodes, T.L.; Finkenthal, D.; Hillis, D.L.; Wade, M.R.; Matsumoto, H.; Watkins, J.G.

    1992-07-01

    Combined theoretical and experimental work has resulted in the creation of a paradigm which has allowed semi-quantitative understanding of the edge confinement improvement that occurs in the H-mode. Shear in the E x B flow of the fluctuations in the plasma edge can lead to decorrelation of the fluctuations, decreased radial correlation lengths and reduced turbulent transport. Changes in the radial electric field, the density fluctuations and the edge transport consistent with shear stabilization of turbulence have been seen in several tokamaks. The purpose of this paper is to discuss the most recent data in the light of the basic paradigm of electric field shear stabilization and to critically compare the experimental results with various theories

  15. Dependence of H-mode power threshold on global and local edge parameters

    International Nuclear Information System (INIS)

    Groebner, R.J.; Carlstrom, T.N.; Burrell, K.H.

    1995-12-01

    Measurements of local electron density n e , electron temperature T e , and ion temperature T i have been made at the very edge of the plasma just prior to the transition into H-mode for four different single parameter scans in the DIII-D tokamak. The means and standard derivations of n e , T e , and T i under these conditions for a value of the normalized toroidal flux of 0.98 are respectively, 1.5 ± 0.7 x 10 19 m -3 , 0.051 ± 0.016 keV, and 0.14 ± 0.03 keV. The threshold condition for the transition is more sensitive to temperature than to density. The data indicate that the dependence is not as simple as a requirement for a fixed value of the ion collisionality

  16. SOLPS5 modelling of the type III ELMing H-mode on TCV

    International Nuclear Information System (INIS)

    Gulejova, B.; Pitts, R.A.; Wischmeier, M.; Behn, R.; Coster, D.; Horacek, J.; Marki, J.

    2007-01-01

    Although ohmic H-modes have long been produced on TCV and the effects of ELMs at the divertor target studied in some detail, no attempt has yet been made to model the scrape-off layer (SOL) in these plasmas. This paper describes details of the first such efforts in which simulations of the inter-ELM phases using the coupled fluid-Monte Carlo SOLPS5 code (without drifts) are constrained by careful upstream Thomson scattering and Langmuir probe profiles. Simulated divertor profiles are compared with Langmuir probes and fast IR camera measurements at the targets. To account for the very differing transport rates in the edge pedestal and main SOL regions, radial variation of edge transport coefficients has been introduced in the simulations. Similarly, it is found that transport in the main chamber and divertor regions must be separately adjusted to provide an acceptable code-experiment match

  17. The 13th International Workshop on H-mode Physics and Transport Barriers (Oxford, UK, 2011) The 13th International Workshop on H-mode Physics and Transport Barriers (Oxford, UK, 2011)

    Science.gov (United States)

    Saibene, G.

    2012-11-01

    The 13th International Workshop on H-mode Physics and Transport Barriers, held in Lady Margaret Hall College in Oxford in October 2011 continues the tradition of bi-annual international meetings dedicated to the study of transport barriers in fusion plasmas. The first meeting of this series took place in S Diego (CA, US) in 1987, and since then scientists in the fusion community studying the formation and effects of transport barriers in plasmas have been meeting at this small workshop to discuss progress, new experimental evidence and related theoretical studies. The first workshops were strongly focussed on the characterization and understanding of the H-mode plasma, discovered in ASDEX in 1982. Tokamaks throughout the entire world were able to reproduce the H-mode transition in the following few years and since then the H-mode has been recognised as a pervasive physics feature of toroidally confined plasmas. Increased physics understanding of the H-mode transition and of the properties of H-mode plasmas, together with extensive development of diagnostic capabilities for the plasma edge, led to the development of edge transport barrier studies and theory. The H-mode Workshop reflected this extension in interest, with more and more contributions discussing the phenomenology of edge transport barriers and instabilities (ELMs), L-H transition and edge transport barrier formation theory. In the last 15 years, in response to the development of fusion plasma studies, the scientific scope of the workshop has been broadened to include experimental and theoretical studies of both edge and internal transport barriers, including formation and sustainment of transport barriers for different transport channels (energy, particle and momentum). The 13th H-mode Workshop was organized around six leading topics, and, as customary for this workshop, a lead speaker was selected for each topic to present to the audience the state-of-the-art, new understanding and open issues, as well

  18. Measurement of peripheral electron temperature by electron cyclotron emission during the H-mode transition in JFT-2M tokamak

    International Nuclear Information System (INIS)

    Hoshino, Katsumichi; Yamamoto, Takumi; Kawashima, Hisato

    1987-01-01

    Time evolution and profile of peripheral electron temperature during the H-mode like transition in a tokamak plasma is measured using the second and third harmonic of electron cyclotron emission (ECE). The so called ''H-mode'' state which has good particle/energy confinement is characterized by sudden decrease in the spectral line intensity of deuterium molecule. Such a sudden decrease in the line intensity of D α with good energy confinement is found not only in divertor discharges, but also in limiter dischargs in JFT-2M tokamak. It is found by the measurement of ECE that the peripheral electron temperature suddenly increases in both of such phases. The relation between H-transition and the peripheral electron temperature or its profile is investigated. (author)

  19. Measurement of isotopic composition of lanthanides in reprocessing process solutions by high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC/ICP-MS)

    International Nuclear Information System (INIS)

    Okano, Masanori; Jitsukata, Shu; Kuno, Takehiko; Yamada, Keiji

    2011-01-01

    Isotopic compositions of fission products in process solutions and wastes in a reprocessing plant are valuable to proceed safety study of the solutions and research/development concerning treatment/disposal of the wastes. The amount of neodymium-148 is a reliable indication to evaluate irradiation history. The isotopic compositions of samarium and gadolinium in high radioactive wastes are referred to as essential data to evaluate environmental impact in geological repositories. However, pretreatment of analysis must be done with complicated chemical separation such as solvent extraction and ion exchange. The actual measurement data of isotopic compositions of lanthanides comparable to the one of actinides in spent fuel reprocessing process has not been obtained enough. Rapid and high sensitive analytical technique based on high-performance liquid chromatography (HPLC) with an inductively coupled plasma mass spectrometry (ICP-MS) has been developed for the measurement of isotopic compositions of lanthanides in spent fuel reprocessing solutions. HPLC/ICP-MS measurement system was customized for a glove-box to be applied to the radioactive solutions. The cation exchange chromatographic columns (Shim-pack IC-C1) and injection valve (20μL) were located inside of the glove-box except the chromatographic pump. The elements of lanthanide group were separated by a gradient program of HPLC with α-hydroxyisobutyric acid. Isotopic compositions of lanthanides in eluate was sequentially analyzed by a quadruple ICP-MS. Optimization of parameter of HPLC and ICP-MS measurement system was examined with standard solutions containing 14 lanthanide elements. The elements of lanthanides were separated by HPLC and detected by ICP-MS within 25 minutes. The detection limits of Nd-146, Sm-147 and Gd-157 were 0.37 μg L -1 , 0.69 μg L -1 and 0.47 μg L -1 , respectively. The analytical precision of the above three isotopes was better than 10% for standard solutions of 100 μg L -1 with

  20. Suppression of tungsten accumulation during ELMy H-mode by lower hybrid wave heating in the EAST tokamak

    Directory of Open Access Journals (Sweden)

    L. Zhang

    2017-08-01

    Full Text Available EAST tokamak has been equipped with upper tungsten divertor since 2014. The tungsten accumulation has been often observed in NBI-heated H-mode discharges suggesting deleterious tungsten confinement in the plasma core. It causes not only H-L back transition but also plasma disruption in several discharges. Suppression of the tungsten accumulation is therefore the most important issue in EAST to achieve a long pulse H-mode discharge. In order to study the tungsten behavior in the long pulse discharge, tungsten spectra have been measured at 20–140Å. The tungsten density, nw, is evaluated from the intensity of tungsten unresolved transition array (W-UTA in a wavelength range of 45–70Å which is composed of several ionization stages of tungsten, e.g. W27+-W45+ at Te0∼2.5keV. It is found that the tungsten accumulation can be suppressed when the 4.6GHz LHW with PLHW∼0.8MW is superimposed on the NBI phase (PNBI= 1.9MW. During the superimposed phase the ELM frequency, fELM, increases from ∼30Hz to ∼60Hz and the tungsten density is halved compared to the NBI-heated discharge. The H-mode discharge can be thus steadily sustained for longer period. It is found that the nw is a large function of the ratio of LHW power to the total injection power, PLHW/(PLHW+PNBI, and the nw can be reduced, at least, in an order of magnitude smaller than that in NBI-heated discharges at PLHW/(PLHW+PNBI≥0.8. The result strongly suggests a possible way toward the steady H-mode discharge.

  1. Heuristic Drift-based Model of the Power Scrape-off width in H-mode Tokamaks

    International Nuclear Information System (INIS)

    Goldston, Robert J.

    2011-01-01

    An heuristic model for the plasma scrape-off width in H-mode plasmas is introduced. Grad B and curv B drifts into the SOL are balanced against sonic parallel flows out of the SOL, to the divertor plates. The overall particle flow pattern posited is a modification for open field lines of Pfirsch-Shlueter flows to include sinks to the divertors. These assumptions result in an estimated SOL width of ∼ 2αρ p /R. They also result in a first-principles calculation of the particle confinement time of H-mode plasmas, qualitatively consistent with experimental observations. It is next assumed that anomalous perpendicular electron thermal diffusivity is the dominant source of heat flux across the separatrix, investing the SOL width, defined above, with heat from the main plasma. The separatrix temperature is calculated based on a two-point model balancing power input to the SOL with Spitzer-Haerm parallel thermal conduction losses to the divertor. This results in a heuristic closed-form prediction for the power scrape-off width that is in reasonable quantitative agreement both in absolute magnitude and in scaling with recent experimental data from deuterium plasmas. Further work should include full numerical calculations, including all magnetic and electric drifts, as well as more thorough comparison with experimental data.

  2. Quiescent H-mode operation using torque from non-axisymmetric, non-resonant magnetic fields

    International Nuclear Information System (INIS)

    Burrell, K.H.; Garofalo, A.M.; Osborne, T.H.; Snyder, P.B.; Solomon, W.M.; Park, J.-K.; Fenstermacher, M.E.; Orlov, D.M.

    2013-01-01

    Quiescent H-mode (QH-mode) sustained by magnetic torque from non-axisymmetric magnetic fields is a promising operating mode for future burning plasmas including ITER. Using magnetic torque from n = 3 fields to replace counter-I p torque from neutral beam injection, we have achieved long duration, counter-rotating QH-mode operation with neutral beam injection (NBI) torque ranging continuously from counter-I p up to co-I p values of about 1 N m. This co-I p torque is about 3 times the scaled torque that ITER will have. This range also includes operation at zero net NBI torque, applicable to rf wave heated plasmas. These n = 3 fields have been created using coils either inside or, most recently, outside the toroidal coils. Experiments utilized an ITER-relevant lower single-null plasma shape and were done with ITER-relevant values ν ped * ∼0.08, β T ped ∼ 1%$ and β N = 2. Discharges have confinement quality H 98y2 = 1.3, exceeding the value required for ITER. Initial work with low q 95 = 3.4 QH-mode plasmas transiently reached fusion gain values of G = β N H 89 /q 95 2 =0.4, which is the desired value for ITER; the limits on G have not yet been established. This paper also includes the most recent results on QH-mode plasmas run without n = 3 fields and with co-I p NBI; these shots exhibit co-I p plasma rotation and require NBI torque ⩾2 N m. The QH-mode work to date has made significant contact with theory. The importance of edge rotational shear is consistent with peeling–ballooning mode theory. We have seen qualitative and quantitative agreement with the predicted torque from neoclassical toroidal viscosity. (paper)

  3. A simple high-performance liquid chromatography (HPLC) method for the measurement of pyridoxal-5-phosphate and 4-pyridoxic acid in human plasma.

    Science.gov (United States)

    Cabo, Rona; Kozik, Karolina; Milanowski, Maciej; Hernes, Sigrunn; Slettan, Audun; Haugen, Margaretha; Ye, Shu; Blomhoff, Rune; Mansoor, M Azam

    2014-06-10

    Low concentration of plasma pyridoxal-5-phosphate (PLP) is associated with hyperhomocysteinemia and inflammation. Most methods for the measurement of plasma PLP require large specimen volume and involve the use of toxic reagents. We have developed a HPLC method for the measurement of PLP and 4-pyridoxic acid (4-PA) in plasma, which requires small specimen volume. The samples are prepared without adding any toxic reagents. Furthermore, we have examined whether intake of vitamin B6 affects the concentration of plasma PLP and 4-PA. The coefficient of variation of the method was 6% and the recovery of the added vitamin in plasma was about 100%. The concentrations of plasma PLP and 4-PA in 168 healthy subjects were 40.6 (8.4-165.0) nmol/L, median and (range) and 17.5 (3.7-114.79) nmol/L, median and (range) respectively. In the multiple regression analyses, the concentration of plasma PLP was associated with the concentration of plasma 4-PA (pplasma 4-PA was associated with plasma PLP (pplasma PLP and 4-PA. Our findings demonstrate that plasma 4-PA, BMI and sex are the major determinants of plasma PLP in healthy individuals. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Effect of ripple-induced transport on H-mode performance in tokamaks

    International Nuclear Information System (INIS)

    Parail, V.; Vries, P. de; Lonnroth, J.; Kiviniemi, T.; Johnson, T.; Loarte, A.; Saibene, G.; Hatae, T.; Kamada, Y.; Konovalov, S.; Oyama, N.; Shinohara, K.; Tobita, K.; Urano, H.

    2005-01-01

    A number of experiments have shown that ripple-induced transport influences performance of ELMy H-modes in the tokamak. A noticeable difference in confinement, ELM frequency and amplitude was found between JET (with ripple amplitude δ∼0.1%) and JT-60U (with δ∼1%) in otherwise identical discharges. It was previously shown in JET experiments with enhanced ripple that a gradual increase in the ripple amplitude first leads to a modest improvement in plasma confinement, which is followed by the degradation of edge pedestal and further transition to the L-mode regime if δ increases further. The DIII-D team recently reported a marginal increase in confinement in experiments with an edge transport enhanced by the externally driven resonant magnetic perturbation. Numerical predictive modelling of the dynamics of ELMy H-mode JET plasma relevant to a JET/JT-60U similarity experiment has been conducted taking into account ripple-induced ion transport, which was computed using the orbit following code ASCOT. This predictive modelling reveals that, depending on plasma parameters, ripple amplitude and localisation (the latter depending on the toroidal coil design), this additional transport can either improve global plasma confinement or reduce it. These controlled ripple losses might be used as an effective tool for ELM mitigation and may provide an explanation for the difference between JET and JT-60U observed in the similarity experiments. A detailed comparison between ripple- induced transport and the alternative method of ELM mitigation by an externally driven edge magnetic perturbation is discussed. The fact that ripple losses mainly increase ion transport, while a stochastic magnetic layer increases electron transport indicates that it might be beneficial to use a combination of both methods in future experiments. This work was funded partly by the United Kingdom Engineering and Physical Sciences Research Council and by the European Communities under the contract of

  5. Determination of 20 trace elements and arsenic species for a realgar-containing traditional Chinese medicine Niuhuang Jiedu tablets by direct inductively coupled plasma-mass spectrometry and high performance liquid chromatography-inductively coupled plasma-mass spectrometry.

    Science.gov (United States)

    Jin, Pengfei; Liang, Xiaoli; Xia, Lufeng; Jahouh, Farid; Wang, Rong; Kuang, Yongmei; Hu, Xin

    2016-01-01

    Niuhuang Jiedu tablet (NHJDT) is a realgar-containing traditional Chinese medicine. A direct inductively coupled plasma-mass spectrometry (ICP-MS) method for the simultaneous determination of 20 trace elements (Mg, K, Ca, Na, Fe, As, Zn, Sr, Ba, Cu, Mn, Ni, Pb, V, Cr, Se, Co, Mo, Cd, Hg) in NHJDT, as well as in water, gastric fluid and intestinal fluid was established. Meanwhile, a high performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) method was developed for the determination of arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and for the identification of arsenobetaine (AsB) and arsenocholine (AsC) in these extracts. Both methods were fully validated in the respect of linearity, sensitivity, precision, stability and accuracy. The reliability of the ICP-MS method was further evaluated using a certified standard reference material prepared from dried tomato leaves (NIST, SRM 1572a). The analysis showed that some manufacturers formulated lower amount of realgar than required in the Chinese Pharmacopoeia (ChP) in their preparations. In addition, almost same extraction profiles for total As and inorganic As were found in water and in gastrointestinal fluids, while higher extraction rates for other 19 elements were observed in gastrointestinal fluids. Our findings show that the toxicities of Hg, Cu, Cd and Pb in NHJDP are low, while the real As toxicity in NHJDT should be deeply investigated. Copyright © 2015 Elsevier GmbH. All rights reserved.

  6. Observation of precursor magnetic oscillations to the H-mode transition of ASDEX

    International Nuclear Information System (INIS)

    Toi, K.; Gernhardt, J.; Klueber, O.; Kornherr, M.

    1988-05-01

    Precursor oscillations to the H-mode transition are identified in magnetic fluctuations of the ASDEX H-mode discharges initiated without a sawtooth. This precursor is m=4/n=1 mode, rotating with f ≅ 10 kHz in the opposite direction to co-injected neutral beams. Time behaviour of the amplitude suggests that the H-mode transition is caused, not by the edge electron temperature, but by the edge current density. (orig.)

  7. An Heuristic Drift-Based Model of the Power Scrape-Off Width in H-Mode Tokamaks

    International Nuclear Information System (INIS)

    Goldston, Robert J.

    2011-01-01

    An heuristic model for the plasma scrape-off width in H-mode plasmas is introduced. Grad B and curv B drifts into the SOL are balanced against sonic parallel flows out of the SOL, to the divertor plates. The overall mass flow pattern posited is a modification for open field lines of Pfirsch-Shlueter flows to include sinks to the divertors. These assumptions result in an estimated SOL width of 2αρ p /R. They also result in a first-principles calculation of the particle confinement time of H-mode plasmas, qualitatively consistent with experimental observations. It is next assumed that anomalous perpendicular electron thermal diffusivity is the dominant source of heat flux across the separatrix, investing the SOL width, defined above, with heat from the main plasma. The separatrix temperature is calculated based on a two-point model balancing power input to the SOL with Spitzer-Haerm parallel thermal conduction losses to the divertor. This results in an heuristic closed-form prediction for the power scrape-off width that is in remarkable quantitative agreement both in absolute magnitude and in scaling with recent experimental data. Further work should include full numerical calculations, including all magnetic and electric drifts, as well as more thorough comparison with experimental data.

  8. High performance homes

    DEFF Research Database (Denmark)

    Beim, Anne; Vibæk, Kasper Sánchez

    2014-01-01

    Can prefabrication contribute to the development of high performance homes? To answer this question, this chapter defines high performance in more broadly inclusive terms, acknowledging the technical, architectural, social and economic conditions under which energy consumption and production occur....... Consideration of all these factors is a precondition for a truly integrated practice and as this chapter demonstrates, innovative project delivery methods founded on the manufacturing of prefabricated buildings contribute to the production of high performance homes that are cost effective to construct, energy...

  9. Determination of the lactone and lactone plus carboxylate forms of 9-aminocamptothecin in human plasma by sensitive high-performance liquid chromatography with fluorescence detection

    NARCIS (Netherlands)

    W.J. Loos (Walter); A. Sparreboom (Alex); J. Verweij (Jaap); K. Nooter (Kees); G. Stoter (Gerrit); J.H.M. Schellens (Jan)

    1997-01-01

    textabstractTwo sensitive reversed-phase high-performance liquid chromatographic fluorescence methods, with simple sample handling at the site of the patient, are described for the determination of the lactone and lactone plus carboxylate forms of g-aminocamptothecin (9AC). For 9AC lactone, the

  10. The influence of gas fuelling location on H-mode access in the MAST spherical tokamak

    International Nuclear Information System (INIS)

    Field, A R; Carolan, P G; Conway, N J; Counsell, G F; Cunningham, G; Helander, P; Meyer, H; Taylor, D; Tournianski, M R; Walsh, M J

    2004-01-01

    The observation that high-field side (HFS) gas puff refuelling facilitates access to the improved confinement (H-mode) regime on the COMPASS-D and MAST tokamaks prompted a theoretical investigation of the role of the neutral gas dynamics in controlling the edge plasma rotation and radial E-field, E r . Within the framework of neo-classical theory, higher edge plasma flow, and hence E r , are predicted when fuelling from the HFS-rather than from the more usual low-field side (LFS)-provided neutral viscosity dominates the transport of toroidal angular momentum. Here, these predictions are compared with experiments on MAST, where the influence of the gas-puff location on the edge E r profile is measured spectroscopically. An increase in E r is indeed observed with HFS refuelling in the region where the edge transport barrier forms, provided the neutral density at the LFS is sufficiently low so as not to damp the toroidal flow

  11. H-mode threshold power scaling and the ∇B drift effect

    International Nuclear Information System (INIS)

    Carlstrom, T.N.; Burrell, K.H.; Groebner, R.J.; Staebler, G.M.

    1997-06-01

    One of the largest influences on the H-mode power threshold (P TH ) is the direction of the ion ∇B drift relative to the X-point location, where factors of 2--3 increase in P TH are observed for the ion ∇B drift away from the X-point. It is proposed that the threshold power scaling observed in single-null configurations with the ion ∇B drift toward the X-point location (P TH ∼ nB, where n is the plasma density, and B is the toroidal field) is due to the scaling of the magnitude of the ∇B drift effect. Hinton and later Hinton and Stebler have modeled this effect as neoclassical cross field fluxes of both heat and particles driven by poloidal temperature gradients on the open field lines in the scrape-off layer (SOL). The ∇B drift effect influences the power threshold by affecting the edge conditions needed for the L-H transition. It is not essential for the L-H transition itself since transitions are observed with either direction of B. Predictions of this model include saturation of the B scaling of P TH at high field, 1/B scaling of P TH with reverse B, and no B scaling of P TH in balanced double-null configurations. This last prediction is consistent with the observed scaling of p TH in double-null plasma sin DIII-D

  12. Ohmic H-mode and confinement in TCV

    Czech Academy of Sciences Publication Activity Database

    Moret, J. M.; Anton, M.; Barry, S.; Behn, R.; Besson, G.; Buhlmann, F.; Burri, A.; Chavan, R.; Corboz, M.; Deschenaux, C.; Dutch, M. J.; Duval, B. P.; Fasel, A.; Favre, A.; Franke, S.; Hirt, A.; Hofmann, F.; Hollenstein, C.; Isoz, P. F.; Joye, B.; Lister, J. B.; Llobet, X.; Magnin, J. C.; Mandrin, P.; Marletaz, B.; Marmillod, P.; Martin, Y.; Mayor, J. M.; Moravec, Jaroslav; Nieswand, C.; Paris, P. J.; Perez, A.; Pietrzyk, Z. A.; Piffl, Vojtěch; Pitts, R. A.; Pochelon, A.; Sauter, O.; Toledo van, W.; Tonetti, G.; Tran, M. Q.; Troyon, F.; Ward, D. J.; Weisen, H.

    1995-01-01

    Roč. 37, 11A (1995), s. A215-A226 ISSN 0741-3335. [EPS Conference on Controlled Fusion and Plasma Physics /22./. Bournemouth, 03.07.1995-07.07.1995] R&D Projects: GA AV ČR IAA1043501 Impact factor: 2.020, year: 1995

  13. Vitamin D analysis in plasma by high performance liquid chromatography (HPLC) with C30 reversed phase column and UV detection - easy and acetonitrile-free

    DEFF Research Database (Denmark)

    Hymøller, Lone; Jensen, Søren Krogh

    2011-01-01

    Two physiologically important forms of vitamin D exist: vitamin D2 and vitamin D3, which by liver based hydroxylase enzymes are converted to 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, respectively. These hydroxylated metabolites of vitamin D are measured in plasma to assess the vtamin D status...... detection at 265nm for quantifying vitamin D2, vitamin D3, 25-hydroxyvitamin D2, and 25-hydroxyvitamin D3. The method proved versatile with respect to plasma lipid content, sample amount, and plasma concentration of the vitamin D metabolites as it was tested using plasma from six different species: cattle...... material® 972 “Vitamin D in human serum” from the National Institute of Standards and Technology (NIST) (Gaithersburg, USA) the results for 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 concentrations were within the boundaries provided by NIST, reflected by Z-scores between 0.1 and 0.9....

  14. Papers presented at the IAEA technical committee meeting on H-mode physics

    International Nuclear Information System (INIS)

    TCV team

    1995-11-01

    The two papers contained in this report deal with ohmic H-modes and effect on confinement of edge localized modes in the TCV tokamak. They were presented by the TCV team at the 1995 IAEA technical committee meeting on H-mode physics. figs., tabs., refs

  15. The H-mode Pedestal and Edge Localized Modes in NSTX

    International Nuclear Information System (INIS)

    Maingi, R.; Fredrickson, E.D.; Menard, J.E.; Nishino, N.; Roquemore, A.L.; Sabbagh, S.A.; Tritz, K.

    2004-01-01

    The research program of the National Spherical Torus Experiment (NSTX) routinely utilizes the H-mode confinement regime to test and extend beta and pulse length limits. As in conventional aspect ratio tokamaks, NSTX observes a variety of edge localized modes (ELMs) in H-mode. Hence a significant part of the research program is dedicated to ELMs studies

  16. PREFACE: 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers

    Science.gov (United States)

    Takizuka, Tomonori

    2008-07-01

    This volume of Journal of Physics: Conference Series contains papers based on invited talks and contributed posters presented at the 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers. This meeting was held at the Tsukuba International Congress Center in Tsukuba, Japan, on 26-28 September 2007, and was organized jointly by the Japan Atomic Energy Agency and the University of Tsukuba. The previous ten meetings in this series were held in San Diego (USA) 1987, Gut Ising (Germany) 1989, Abingdon (UK) 1991, Naka (Japan) 1993, Princeton (USA) 1995, Kloster Seeon (Germany) 1997, Oxford (UK) 1999, Toki (Japan) 2001, San Diego (USA) 2003, and St Petersburg (Russia) 2005. The purpose of the eleventh meeting was to present and discuss new results on H-mode (edge transport barrier, ETB) and internal transport barrier, ITB, experiments, theory and modeling in magnetic fusion research. It was expected that contributions give new and improved insights into the physics mechanisms behind high confinement modes of H-mode and ITBs. Ultimately, this research should lead to improved projections for ITER. As has been the tradition at the recent meetings of this series, the program was subdivided into six topics. The topics selected for the eleventh meeting were: H-mode transition and the pedestal-width Dynamics in ETB: ELM threshold, non-linear evolution and suppression, etc Transport relations of various quantities including turbulence in plasmas with ITB: rotation physics is especially highlighted Transport barriers in non-axisymmetric magnetic fields Theory and simulation on transport barriers Projections of transport barrier physics to ITER For each topic there was an invited talk presenting an overview of the topic, based on contributions to the meeting and on recently published external results. The six invited talks were: A Leonard (GA, USA): Progress in characterization of the H-mode pedestal and L-H transition N Oyama (JAEA, Japan): Progress and issues in

  17. Results of the H-mode experiments with JT-60 outer and lower divertors

    International Nuclear Information System (INIS)

    Nakamura, Hiroo; Tsuji, Shunji; Nagami, Masayuki

    1989-08-01

    In JT-60, hydrogen H-mode experiments with outer and lower divertors were performed. In the outer divertor, H-mode were obtained, similar to the ones observed in the other lower/upper divertors. Its threshold absorbed power and electron density were 16 MW and 1.8 x 10 19 m -3 . In the two combined heatings with NB+ICRF and NB+LHRF, H-mode discharges are also obtained. Moreover, in new configuration of lower divertor, H-mode phases without and with ELM are obtained. Typical results of the lower divertor are shown to compare the H-mode characteristics between the two configurations. Improvement of the energy confinement time in the two divertors was limited to 10 %. Analyses on ballooning/interchange instabilities were carried out with precise equlibria of JT-60. These results showed that the both modes were enough stable. (author)

  18. H-mode WEST tungsten divertor operation: deuterium and nitrogen seeded simulations with SOLEDGE2D-EIRENE

    Directory of Open Access Journals (Sweden)

    G. Ciraolo

    2017-08-01

    Full Text Available Simulations of WEST H-mode divertor scenarios have been performed with SOLEDGE2D-EIRENE edge plasma transport code, both for pure deuterium and nitrogen seeded discharge. In the pure deuterium case, a target heat flux of 8 MW/m2 is reached, but misalignment between heat and the particle outflux yields 50 eV plasma temperature at the target plates. With nitrogen seeding, the heat and particle outflux are observed to be aligned so that lower plasma temperatures at the target plates are achieved together with the required high heat fluxes. This change in heat and particle outflux alignment is analysed with respect to the role of divertor geometry and the impact of vertical vs horizontal target plates on neutrals spreading.

  19. High Performance Marine Vessels

    CERN Document Server

    Yun, Liang

    2012-01-01

    High Performance Marine Vessels (HPMVs) range from the Fast Ferries to the latest high speed Navy Craft, including competition power boats and hydroplanes, hydrofoils, hovercraft, catamarans and other multi-hull craft. High Performance Marine Vessels covers the main concepts of HPMVs and discusses historical background, design features, services that have been successful and not so successful, and some sample data of the range of HPMVs to date. Included is a comparison of all HPMVs craft and the differences between them and descriptions of performance (hydrodynamics and aerodynamics). Readers will find a comprehensive overview of the design, development and building of HPMVs. In summary, this book: Focuses on technology at the aero-marine interface Covers the full range of high performance marine vessel concepts Explains the historical development of various HPMVs Discusses ferries, racing and pleasure craft, as well as utility and military missions High Performance Marine Vessels is an ideal book for student...

  20. High Performance Macromolecular Material

    National Research Council Canada - National Science Library

    Forest, M

    2002-01-01

    .... In essence, most commercial high-performance polymers are processed through fiber spinning, following Nature and spider silk, which is still pound-for-pound the toughest liquid crystalline polymer...

  1. Determination of vitamin B6 vitamers and pyridoxic acid in plasma: development and evaluation of a high-performance liquid chromatographic assay

    DEFF Research Database (Denmark)

    Bisp, Marianne R; Bor, Mustafa Vakur; Heinsvig, Else-Marie

    2002-01-01

    buffer containing 1 g/L sodium bisulfite. The performance of the assay was evaluated by analyzing six plasma samples with interrelated concentration and two control samples (unspiked and vitamer spiked) over a 3-months period. The HPLC method was able to identify PLP, 4-PA, PM, PL, PN, and PMP from all...... other compounds in plasma in an analytical run of 46 min. The imprecisions and mean values (presented in parenthesis in nmol/L) were (unspiked and spiked sample) 9-8% (41-65) for PLP, 12-7% (18-40) for 4-PA, 67-28% (4-19) for PL, 15% (21) for PN, 10% (27) for PM, and 27% (17) for PMP. All three B6...... will be suitable for routine quantitation of PLP and 4-PA in human plasma. Udgivelsesdato: 2002-Jun-1...

  2. Determination of levodopa in human plasma by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS: application to a bioequivalence study

    Directory of Open Access Journals (Sweden)

    Heliana F. Martins

    2013-01-01

    Full Text Available A sensitive, accurate and simple method using HPLC-MS/MS was developed and validated for levodopa quantitation in human plasma. Analysis was achieved on a pursuit® C18 analytical column (5 µm; 150 x 4.6 mm i.d. using a mobile phase (methanol and water , 90:10, v/v containing formic acid 0.5% v/v, after extracting the samples using a simple protein plasma precipitation with perchloric acid. The developed method was validated in accordance with ANVISA guidelines and was successfully applied to a bioequivalence study in 60 healthy volunteers demonstrating the feasibility and reliability of the proposed method.

  3. Studies of energy transport in Jet H-modes

    International Nuclear Information System (INIS)

    Keilhacker, M.; Balet, B.; Cordey, J.; Gottardi, N.; Muir, D.; Thomsen, K.; Watkins, M.

    1989-01-01

    The local heat transport properties in the interior of ohmic, L- and H-phases of 2MA discharges, are determined. Time dependent energy balance code, TRANSP, and timeslice code, QFLUX are used. The global confinement properties of higher current discharges (≤ 3.8MA) are analyzed. The results indicate that during the L-phase of JET single null X-point discharges, the total heat transport coefficient in the plasma decreases to a level close to the ohmic value. Moreover, confinement during the H-phase continues to improve with current (up to 3.8MA), but degrades with increasing neutral beam power

  4. Differences in the H-mode pedestal width of temperature and density

    International Nuclear Information System (INIS)

    Schneider, P A; Wolfrum, E; Günter, S; Kurzan, B; Lackner, K; Zohm, H; Groebner, R J; Osborne, T H; Ferron, J R; Snyder, P B; Beurskens, M N A; Dunne, M G

    2012-01-01

    A pedestal database was built using data from type-I ELMy H-modes of ASDEX Upgrade, DIII-D and JET. ELM synchronized pedestal data were analysed with the two-line method. The two-line method is a bilinear fit which shows better reproducibility of pedestal parameters than a modified hyperbolic tangent fit. This was tested with simulated and experimental data. The influence of the equilibrium reconstruction on pedestal parameters was investigated with sophisticated reconstructions from CLISTE and EFIT including edge kinetic profiles. No systematic deviation between the codes could be observed. The flux coordinate system is influenced by machine size, poloidal field and plasma shape. This will change the representation of the width in different coordinates, in particular, the two normalized coordinates Ψ N and r/a show a very different dependence on the plasma shape. The scalings derived for the pedestal width, Δ, of all machines suggest a different scaling for the electron temperature and the electron density. Both cases show similar dependence with machine size, poloidal magnetic field and pedestal electron temperature and density. The influence of ion temperature and toroidal magnetic field is different on each of Δ T e and Δ n e . In dimensionless form the density pedestal width in Ψ N scales with ρ 0.6 i* , the temperature pedestal width with β p,ped 0.5 . Both widths also show a strong correlation with the plasma shape. The shape dependence originates from the coordinate transformation and is not visible in real space. The presented scalings predict that in ITER the temperature pedestal will be appreciably wider than the density pedestal. (paper)

  5. Role of Density Gradient Driven Trapped Electron Modes in the H-Mode Inner Core with Electron Heating

    Science.gov (United States)

    Ernst, D.

    2015-11-01

    We present new experiments and nonlinear gyrokinetic simulations showing that density gradient driven TEM (DGTEM) turbulence dominates the inner core of H-Mode plasmas during strong electron heating. Thus α-heating may degrade inner core confinement in H-Mode plasmas with moderate density peaking. These DIII-D low torque quiescent H-mode experiments were designed to study DGTEM turbulence. Gyrokinetic simulations using GYRO (and GENE) closely match not only particle, energy, and momentum fluxes, but also density fluctuation spectra, with and without ECH. Adding 3.4 MW ECH doubles Te /Ti from 0.5 to 1.0, which halves the linear TEM critical density gradient, locally flattening the density profile. Density fluctuations from Doppler backscattering (DBS) intensify near ρ = 0.3 during ECH, displaying a band of coherent fluctuations with adjacent toroidal mode numbers. GYRO closely reproduces the DBS spectrum and its change in shape and intensity with ECH, identifying these as coherent TEMs. Prior to ECH, parallel flow shear lowers the effective nonlinear DGTEM critical density gradient 50%, but is negligible during ECH, when transport displays extreme stiffness in the density gradient. GS2 predictions show the DGTEM can be suppressed, to avoid degradation with electron heating, by broadening the current density profile to attain q0 >qmin > 1 . A related experiment in the same regime varied the electron temperature gradient in the outer half-radius (ρ ~ 0 . 65) using ECH, revealing spatially coherent 2D mode structures in the Te fluctuations measured by ECE imaging. Fourier analysis with modulated ECH finds a threshold in Te profile stiffness. Supported by the US DOE under DE-FC02-08ER54966 and DE-FC02-04ER54698.

  6. Arsenic speciation in seafood samples with emphasis on minor constituents. An investigation by high performance liquid chromatography with inductively coupled plasma mass spectrometric detection

    DEFF Research Database (Denmark)

    Larsen, Erik Huusfeldt; Pritzl, G.; Hansen, S. H.

    1993-01-01

    Extracts of 11 samples of shrimp, crab, fish, fish liver, shellfish and lobster digestive gland (hepatopancreas), including five certified reference materials, were investigated for their contents of arsenic compounds (arsenic speciation). The cation-exchange high performance liquid chromatography...... (as arsenic atom) relative to the total arsenic extracted from the samples were: arsenobetaine 19-98%, arsenocholine and trimethylarsine oxide 0-0.6% and the trimethylarsonium ion 0-2.2%. Additionally, an unknown arsenic species (U1) was present at 3.1-18% in the shellfish and in the lobster digestive...

  7. Speciation of four selenium compounds using high performance liquid chromatography with on-line detection by inductively coupled plasma mass spectrometry or flame atomic absorption spectrometry

    DEFF Research Database (Denmark)

    Pedersen, Gitte Alsing; Larsen, Erik Huusfeldt

    1997-01-01

    An analytical method for the speciation of selenomethionine, selenocystine, selenite and selenate by high performance liquid chromatography (HPLC) with atomic spectrometric detection is presented. An organic polymeric strong anion exchange column was used as the stationary phase in combination...... spectrometry (ICP-MS). The signal-to-noise ratio of the FAAS detector was optimized using a hydrogen-argon entrained-air flame and a slotted-tube atom trap (STAT) in the flame. The limit of detection (3 sigma) achieved by the HPLC-FAAS system was 1 mg L-1 of selenium (100 mu L injections) for each of the four...

  8. Fabrication of high-performance InGaZnOx thin film transistors based on control of oxidation using a low-temperature plasma

    Science.gov (United States)

    Takenaka, Kosuke; Endo, Masashi; Uchida, Giichiro; Setsuhara, Yuichi

    2018-04-01

    This work demonstrated the low-temperature control of the oxidation of Amorphous InGaZnOx (a-IGZO) films using inductively coupled plasma as a means of precisely tuning the properties of thin film transistors (TFTs) and as an alternative to post-deposition annealing at high temperatures. The effects of the plasma treatment of the as-deposited a-IGZO films were investigated by assessing the electrical properties of TFTs incorporating these films. A TFT fabricated using an a-IGZO film exposed to an Ar-H2-O2 plasma at substrate temperatures as low as 300 °C exhibited the best performance, with a field effect mobility as high as 42.2 cm2 V-1 s-1, a subthreshold gate voltage swing of 1.2 V decade-1, and a threshold voltage of 2.8 V. The improved transfer characteristics of TFTs fabricated with a-IGZO thin films treated using an Ar-H2-O2 plasma are attributed to the termination of oxygen vacancies around Ga and Zn atoms by OH radicals in the gas phase.

  9. High-performance liquid chromatographic method for the determination of nicardipine in pure, pharmaceutical preparations and plasma and its application to pharmacokinetics in humans

    Directory of Open Access Journals (Sweden)

    Sheikha M. Al-Ghannam

    2009-01-01

    Full Text Available A simple, sensitive and reproducible reversed-phase liquid chromatographic method has been developed and validated for the determination of nicardipine hydrochloride (NC in pure, pharmaceutical preparations, human plasma and the study of the pharmacokinetics of the drug in human body. Nicardipine in plasma were extracted with hexane-butanol (12:1,v/v after addition of borate buffer (0.5 M, pH=9.0, and then measured by HPLC-UV using a Waters Symmetry C18 column as stationary phase and methanol– triethylamine buffer (0.01M pH 4 with acetic acid (70:30 as mobile phase. Nicardipine was quantified by ultraviolet absorbance at 353 nm. The method proved to be linear in the pure drug in the ranges of 15-200 ng/mL (r=0.9989 and 5-40 ?g/mL (r=0.9995, and for the pharmaceutical preparations and plasma for drug concentrations in the range of 5-40 ?g/mL (r =0.9992 and 25-150 ng/mL (r=0.9991, respectively. The lower limit of detection and the lower quantitation limit of NC in plasma were 11.74 and 35.57 ng/mL, respectively. The method is sensitive and reliable for harmacokineticstudies of nicardipine in humans after the oral administration of immediate-release capsules to healthy subjects.

  10. High-performance liquid chromatographic method for the determination of nicardipine in pure, pharmaceutical preparations and plasma and its application to pharmacokinetics in humans

    Directory of Open Access Journals (Sweden)

    Sheikha Mohammed Al-Ghannam

    2008-12-01

    Full Text Available A simple, sensitive and reproducible reversed-phase liquid chromatographic method has been developed and validated for the determination of nicardipine hydrochloride (NC in pure, pharmaceutical preparations, human plasma and the study of the pharmacokinetics of the drug in human body. Nicardipine in plasma were extracted with hexane-butanol (12:1,v/v after addition of borate buffer (0.5 M, pH=9.0, and then measured by HPLC-UV using a Waters Symmetry C18 column as stationary phase and methanol– triethylamine buffer (0.01M pH 4 with acetic acid (70:30 as mobile phase. Nicardipine was quantified by ultraviolet absorbance at 353 nm. The method proved to be linear in the pure drug in the ranges of 15-200 ng/mL (r=0.9989 and 5-40 µg/mL (r=0.9995, and for the pharmaceutical preparations and plasma for drug concentrations in the range of 5-40 µg/mL (r =0.9992 and 25-150 ng/mL (r=0.9991, respectively. The lower limit of detection and the lower quantitation limit of NC in plasma were 11.74 and 35.57 ng/mL, respectively. The method is sensitive and reliable for pharmacokinetic studies of nicardipine in humans after the oral administration of immediate-release capsules to healthy subjects.

  11. Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography

    NARCIS (Netherlands)

    van Kuilenburg, A. B.; Stroomer, A. E.; Peters, G. J.; van Gennip, A. H.

    2001-01-01

    F-beta-Alanine and beta-alanine were detected in plasma and urine samples with fluorescence detection of orthophthaldialdehyde derivatives of F-beta-alanine and beta-alanine after separation with dual-column reversed-phase HPLC. The detection limits of F-beta-alanine and beta-alanine in the HPLC

  12. Helium Exhaust Studies in H-Mode Discharges in the DIII-D Tokamak Using an Argon-Frosted Divertor Cryopump

    International Nuclear Information System (INIS)

    Wade, M.R.; Hillis, D.L.; Hogan, J.T.; Mahdavi, M.A.; Maingi, R.; West, W.P.; Brooks, N.H.; Burrell, K.H.; Groebner, R.J.; Jackson, G.L.; Klepper, C.C.; Laughon, G.; Menon, M.M.; Mioduszewski, P.K.

    1995-01-01

    The first experiments demonstrating exhaust of thermal helium in a diverted, H-mode deuterium plasma have been performed on the DIII-D tokamak. The helium, introduced via gas puffing, is observed to reach the plasma core, and then is readily removed from the plasma with a time constant of ∼10--20 energy-confinement times by an in-vessel cryopump conditioned with argon frosting. Detailed analysis of the helium profile evolution suggests that the exhaust rate is limited by the exhaust efficiency of the pump (∼5%) and not by the intrinsic helium-transport properties of the plasma

  13. Measurement of deuterium density profiles in the H-mode steep gradient region using charge exchange recombination spectroscopy on DIII-D.

    Science.gov (United States)

    Haskey, S R; Grierson, B A; Burrell, K H; Chrystal, C; Groebner, R J; Kaplan, D H; Pablant, N A; Stagner, L

    2016-11-01

    Recent completion of a thirty two channel main-ion (deuterium) charge exchange recombination spectroscopy (CER) diagnostic on the DIII-D tokamak [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] enables detailed comparisons between impurity and main-ion temperature, density, and toroidal rotation. In a H-mode DIII-D discharge, these new measurement capabilities are used to provide the deuterium density profile, demonstrate the importance of profile alignment between Thomson scattering and CER diagnostics, and aid in determining the electron temperature at the separatrix. Sixteen sightlines cover the core of the plasma and another sixteen are densely packed towards the plasma edge, providing high resolution measurements across the pedestal and steep gradient region in H-mode plasmas. Extracting useful physical quantities such as deuterium density is challenging due to multiple photoemission processes. These challenges are overcome using a detailed fitting model and by forward modeling the photoemission using the FIDASIM code, which implements a comprehensive collisional radiative model.

  14. Ultrasound assisted dispersive liquid-liquid microextraction coupled with high performance liquid chromatography designated for bioavailability studies of felodipine combinations in rat plasma.

    Science.gov (United States)

    Ahmed, Sameh; Atia, Noha N; Bakr Ali, Marwa Fathy

    2017-03-01

    Felodipine (FLD), a calcium channel antagonist, is commonly prescribed for the treatment of hypertension either with Metoprolol (MET) or Ramipril (RAM) in two different drug combinations. FLD has high plasma protein binding ability affecting its extraction recoveries from plasma samples. Hence, a specific ultrasound assisted dispersive liquid-liquid microextraction (UA-DLLME) method coupled with HPLC using photodiode array detector was developed and validated for the simultaneous determination of FLD, MET and RAM in rat plasma after oral administration of these combinations. The factors affecting UA-DLLME were carefully optimized. In this study, UA-DLLME method could provide simple and efficient plasma extraction procedures with superior recovery results. Under optimum condition, all target drugs were separated within 13min. The validation procedures was carried out in agreement with US-FDA guidelines and shown to be suitable for anticipated purposes. Linear calibration ranges were obtained in the range 0.05-2.0μgmL -1 for FLD and MET and 0.1-2.0μgmL -1 for RAM with detection limits of 0.013-0.031μgmL -1 for all the studied drug combinations. The%RSD for inter-day and intra-day precisions was in range of 0.63-3.85% and the accuracy results were in the range of 92.13-100.5%. The validated UA-DLLME-HPLC method was successfully applied for the bioavailability studies of FLD, MET and RAM. The pharmacokinetic parameters were calculated for all the investigated drugs in rats after single-dose administrations of two different drug combinations. Although FLD was bioequivalent in the two formulations, a small increase in plasma levels of MET and RAM was found in the presence of FLD. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of raltegravir, dolutegravir and elvitegravir concentrations in human plasma and cerebrospinal fluid samples.

    Science.gov (United States)

    Tsuchiya, Kiyoto; Ohuchi, Mayu; Yamane, Naoe; Aikawa, Hiroaki; Gatanaga, Hiroyuki; Oka, Shinichi; Hamada, Akinobu

    2018-02-01

    A simple sample treatment procedure and sensitive liquid chromatography-tandem mass spectrometry method were developed for the simultaneous quantification of the concentrations of human immunodeficiency virus-1 integrase strand transfer inhibitors - raltegravir, dolutegravir and elvitegravir - in human plasma and cerebrospinal fluid (CSF). Plasma and CSF samples (20 μL each) were deproteinized with acetonitrile. Raltegravir-d 3 was used as the internal standard. Chromatographic separation was achieved on an XBridge C 18 column (50 × 2.1 mm i.d., particle size 3.5 μm) using acetonitrile-water (7:3, v/v) containing 0.1% formic acid as the mobile phase at a flow rate of 0.2 mL/min. The run time was 5 min. Calibration curves for all three drugs were linear in the range 5-1500 ng/mL for plasma and 1-200 ng/mL for CSF. The intra- and inter-day precision and accuracy of all three drugs in plasma were coefficient of variation (CV) <12.9% and 100.0 ± 12.2%, respectively, while those in CSF were CV <12.3% and 100.0 ± 7.9%, respectively. Successful validation under the same LC-MS/MS conditions for both plasma and CSF indicates this analytical method is useful for monitoring the levels of these integrase strand transfer inhibitors in the management of treatment of HIV-1 carriers. Copyright © 2017 John Wiley & Sons, Ltd.

  16. Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Taylor, Rachel R; Hoffman, Keith L; Schniedewind, Björn; Clavijo, Claudia; Galinkin, Jeffrey L; Christians, Uwe

    2013-09-01

    Acetaminophen (paracetamol, N-(4-hydroxyphenyl) acetamide) is one of the most commonly prescribed drugs for the management of pain in children. Quantification of acetaminophen in pre-term and term neonates and small children requires the availability of highly sensitive assays in small volume blood samples. We developed and validated an LC-MS/MS assay for the quantification of acetaminophen in human plasma, cerebro-spinal fluid (CSF) and dried blood spots (DBS). Reconstitution in water (DBS only) and addition of a protein precipitation solution containing the deuterated internal standard were the only manual steps. Extracted samples were analyzed on a Kinetex 2.6 μm PFP column using an acetonitrile/formic acid gradient. The analytes were detected in the positive multiple reaction mode. Alternatively, DBS were automatically processed using direct desorption in a sample card and preparation (SCAP) robotic autosampler in combination with online extraction. The range of reliable response in plasma and CSF was 3.05-20,000 ng/ml (r(2)>0.99) and 27.4-20,000 ng/ml (r(2)>0.99) for DBS (manual extraction and automated direct desorption). Inter-day accuracy was always within 85-115% and inter-day precision for plasma, CSF and manually extracted DBS were less than 15%. Deming regression analysis comparing 167 matching pairs of plasma and DBS samples showed a correlation coefficient of 0.98. Bland Altman analysis indicated a 26.6% positive bias in DBS, most likely reflecting the blood: plasma distribution ratio of acetaminophen. DBS are a valid matrix for acetaminophen pharmacokinetic studies. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. The H-mode pedestal, ELMs and TF ripple effects in JT-60U/JET dimensionless identity experiments

    International Nuclear Information System (INIS)

    Saibene, G.; Oyama, N.; Loennroth, J.; Andrew, Y.; Luna, E. de la; Giroud, C.; Huysmans, G.T.A.; Kamada, Y.; Kempenaars, M.A.H.; Loarte, A.; Donald, D. Mc; Nave, M.M.F.; Meiggs, A.; Parail, V.; Sartori, R.; Sharapov, S.; Stober, J.; Suzuki, T.; Takechi, M.; Toi, K.; Urano, H.

    2007-01-01

    This paper summarizes results of dimensionless identity experiments in JT-60U and JET, aimed at the comparison of the H-mode pedestal and ELM behaviour in the two devices. Given their similar size, dimensionless matched plasmas are also similar in their dimensional parameters (in particular, the plasma minor radius a is the same in JET and JT-60U). Power and density scans were carried out at two values of I p , providing a q scan (q 95 = 3.1 and 5.1) with fixed (and matched) toroidal field. Contrary to initial expectations, a dimensionless match between the two devices was quite difficult to achieve. In general, p ped in JT-60U is lower than in JET and, at low q, the pedestal pressure of JT-60U with a Type I ELMy edge is matched in JET only in the Type III ELM regime. At q 95 = 5.1, a dimensionless match in ρ*, ν* and β p,ped is obtained with Type I ELMs, but only with low power JET H-modes. These results motivated a closer investigation of experimental conditions in the two devices, to identify possible 'hidden' physics that prevents obtaining a good match of pedestal values over a large range of plasmas parameters. Ripple-induced ion losses of the medium bore plasma used in JT-60U for the similarity experiments are identified as the main difference with JET. The magnitude of the JT-60U ripple losses is sufficient to induce counter-toroidal rotation in co-injected plasma. The influence of ripple losses was demonstrated at q 95 = 5.1: reducing ripple losses by ∼2 (from 4.3 to 1.9 MW) by replacing positive with negative neutral beam injection at approximately constant P in resulted in an increased p ped in JT-60U, providing a good match to full power JET H-modes. At the same time, the counter-toroidal rotation decreased. Physics mechanisms relating ripple losses to pedestal performance are not yet identified, and the possible role of velocity shear in the pedestal stability, as well as the possible influence of ripple on thermal ion transport are briefly

  18. Specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea in plasma.

    Science.gov (United States)

    Supko, J G; Phillips, L R; Malspeis, L

    1996-03-03

    A facile, sensitive and highly specific HPLC method for assaying 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) in plasma has been developed. The drug was efficiently isolated from plasma by extraction with tert.-butyl methyl ether. A structurally related compound with similar physicochemical properties served as the internal standard (I.S.). Following evaporation of the organic solvent, the extract was reconstituted with 0.05 M ammonium acetate buffer, pH 5.0, and loaded onto a 4 micron Nova-Pak C18 column (15 cm x 3.9 mm), which was preceded by a 7 micron Brownlee RP-18 precolumn (1.5 cm x 3.2 mm). Chromatography was performed at ambient temperature using a mobile phase of methanol-0.1 M ammonium formate buffer, pH 3.7 (25:75, v/v). UV absorbance of the effluent was monitored at 240 nm. A flow-rate of 1.0 ml/ min was used for analyzing mouse and dog plasma extracts. Under these conditions, the drug eluted at 4.0 min and was followed by the I.S. at 6.1 min. An automatic switching valve was employed to allow the precolumn to be flushed 1.5 min into the run, without interrupting the flow of the mobile phase to the analytical column, thereby preventing the apparent build-up of extractable, strongly retained, UV-absorbing components present in mouse and dog plasma. Operating in this manner, more than 100 samples could be analyzed during a day using a refrigerated autosampler for overnight injection. The method was readily adapted to the determination of SarCNU in human plasma by simply decreasing the eluent flow-rate to 0.6 ml/min, whereby SarCNU and the I.S. eluted at approximately 5.8 and 9.1 min, respectively. Furthermore, the switching valve was not necessary for the analysis of human plasma samples. With a 50-microliter sample volume, the lowest concentration of SarCNU included in the plasma standard curves, 0.10 micrograms/ml, was quantified with a 7.8% R.S.D. (n = 27) over a 2 month period. Plasma standards, with concentrations of 0.26 to 5

  19. Review of DIII-D H-Mode Density Limit Studies

    International Nuclear Information System (INIS)

    Maingi, R.; Mahdavi, M.A.

    2005-01-01

    Density limit studies over the past 10 yr on DIII-D have successfully identified several processes that limit plasma density in various operating modes. The recent focus of these studies has been on maintenance of the high-density operational window with good H-mode level energy confinement. We find that detachment and onset of multifaceted axisymmetric radiation from the edge (MARFE), fueling efficiency, particle confinement, and magnetohydrodynamic activity can impose density limits in certain regimes. By studying these processes, we have devised techniques with either pellets or gas fueling and divertor pumping to achieve line average density above Greenwald scaling, relying on increasing the ratio of pedestal to separatrix density, as well as density profile peaking. The scaling of several of these processes to next-step devices (e.g., the International Thermonuclear Experimental Reactor) has indicated that sufficiently high pedestal density can be achieved with conventional fueling techniques while ensuring divertor partial detachment needed for heat flux reduction. One density limit process requiring further study is neoclassical tearing mode (NTM) onset, and techniques for avoidance/mitigation of NTMs need additional development in present-day devices operated at high density

  20. X-Divertor Geometries for Deeper Detachment Without Degrading the DIII-D H-Mode

    Science.gov (United States)

    Covele, Brent; Kotschenreuther, M. T.; Valanju, P. M.; Mahajan, S. M.; Leonard, A. W.; Hyatt, A. W.; McLean, A. G.; Thomas, D. M.; Guo, H. Y.; Watkins, J. G.; Makowski, M. A.; Hill, D. N.

    2015-11-01

    Recent DIII-D experiments comparing the standard divertor (SD) and X-Divertor (XD) geometries show heat and particle flux reduction at the divertor target plate. The XD features large poloidal flux expansion, increased connection length, and poloidal field line flaring, quantified by the Divertor Index. Both SD and XD were pushed deep into detachment with increased gas puffing, until core energy confinement and pedestal pressure were substantially reduced. As expected, outboard target heat fluxes are significantly reduced in the XD compared to the SD under similar upstream plasma conditions, even at low Greenwald fraction. The high-triangularity (floor) XD cases show larger reduction in temperature, heat, and particle flux relative to the SD in all cases, while low-triangularity (shelf) XD cases show more modest reductions over the SD. Consequently, heat flux reduction and divertor detachment may be achieved in the XD with less gas puffing and higher pedestal pressures. Further causative analysis, as well as detailed modeling with SOLPS, is underway. These initial experiments suggest the XD as a promising candidate to achieve divertor heat flux control compatible with robust H-mode operation. Work supported by US DOE under DE-FC02-04ER54698, DE-AC52-07NA27344, DE-FG02-04ER54754, and DE-FG02-04ER54742.

  1. Edge operational space for high density/high confinement ELMY H-modes in JET

    International Nuclear Information System (INIS)

    Sartori, R.; Saibene, G.; Loarte, A.

    2002-01-01

    This paper discusses how the proximity to the L-H threshold affects the confinement of ELMy H-modes at high density. The largest reduction in confinement at high density is observed at the transition from the Type I to the Type III ELMy regime. At medium plasma triangularity, δ≅0.3 (where δ is the average triangularity at the separatrix), JET experiments show that by increasing the margin above the L-H threshold power and maintaining the edge temperature above the critical temperature for the transition to Type III ELMs, it is possible to avoid the degradation of the pedestal pressure with density, normally observed at lower power. As a result, the range of achievable densities (both in the core and in the pedestal) is increased. At high power above the L-H threshold power the core density was equal to the Greenwald limit with H97≅0.9. There is evidence that a mixed regime of Type I and Type II ELMs has been obtained at this intermediate triangularity, possibly as a result of this increase in density. At higher triangularity, δ≅0.5, the power required to achieve similar results is lower. (author)

  2. Comparison of H-mode pedestals in different confinement regimes in DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Groebner, R J [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Leonard, A W [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Luce, T C [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Fenstermacher, M E [Lawrence Livermore National Laboratory, Livermore, California (United States); Jackson, G L [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Osborne, T H [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Thomas, D M [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States); Wade, M R [General Atomics, PO Box 85608, San Diego, California, 92186-5608 (United States)

    2006-05-15

    A survey of global performance parameters and their correlation with pedestal parameters is performed for standard H-mode, QH-mode and the enhanced confinement regimes of VH-mode, hybrid and advanced tokamak in the DIII-D tokamak. This study shows that there is a trend for global confinement quality or global beta to increase as the pedestal electron pressure or beta increases. However, there are also improvements in core confinement and beta, observed at fixed pedestal pressure or beta, which indicate that factors other than pedestal parameters also contribute to the best core performance. Several other pedestal structure parameters are found to be similar among these regimes. The scale lengths for electron pressure in the pedestal are in the range 0.8-1.6 cm at the outer midplane, most {eta}{sub e} values are in the range 1-3 in the middle of the T{sub e} pedestal and the T{sub e} and n{sub e} pedestals tend to penetrate the same distance into the plasma.

  3. Structure, stability and ELM dynamics of the H-mode pedestal in DIII-D

    International Nuclear Information System (INIS)

    Fenstermacher, M.E.; Leonard, A.W.; Osborne, T.H.

    2005-01-01

    Experiments are described that have increased understanding of the transport and stability physics that set the H-mode edge pedestal width and height, determine the onset of Type-I edge localized modes (ELMs), and produce the nonlinear dynamics of the ELM perturbation in the pedestal and scrape-off layer (SOL). Predictive models now exist for the n e pedestal profile and the p e height at the onset of Type-I ELMs, and progress has been made toward predictive models of the T e pedestal width and nonlinear ELM evolution. Similarity experiments between DIII-D and JET suggested that neutral penetration physics dominates in the relationship between the width and height of the n e pedestal while plasma physics dominates in setting the T e pedestal width. Measured pedestal conditions including edge current at ELM onset agree with intermediate-n peeling-ballooning (P-B) stability predictions. Midplane ELM dynamics data show the predicted (P-B) structure at ELM onset, large rapid variations of the SOL parameters, and fast radial propagation in later phases, similar to features in nonlinear ELM simulations. (author)

  4. A validated high-performance liquid chromatographic method for the determination of glibenclamide in human plasma and its application to pharmacokinetic studies.

    Science.gov (United States)

    Niopas, Ioannis; Daftsios, Athanasios C

    2002-05-15

    Glibenclamide is a potent second generation oral sulfonylurea antidiabetic agent widely used for the treatment of type II diabetes melitus. A rapid, sensitive, precise, accurate and specific HPLC assay for the determination of glibenclamide in human plasma was developed and validated. After addition of flufenamic acid as internal standard, the analytes were isolated from human plasma by liquid-liquid extraction. The method was linear in the 10-400 ng/ml concentration range (r > 0.999). Recovery for glibenclamide was greater than 91.5% and for internal standard was 93.5%. Within-day and between-day precision, expressed as the relative standard deviation (RSD%), ranged from 1.4 to 5.9% and 5.8 to 6.6%, respectively. Assay accuracy was better than 93.4%. The assay was used to estimate the pharmacokinetics of glibenclamide after oral administration of a 5 mg tablet of glibenclamide to 18 healthy volunteers.

  5. Ion thermal conductivity and convective energy transport in JET hot-ion regimes and H-modes

    International Nuclear Information System (INIS)

    Tibone, F.; Balet, B.; Cordey, J.G.

    1989-01-01

    Local transport in a recent series of JET experiments has been studied using interpretive codes. Auxiliary heating, mainly via neutral beam injection, was applied on low-density target plasmas confined in the double-null X-point configuration. This has produced two-component plasmas with high ion temperature and neutron yield and, above a threshold density, H-modes characterised by peak density and power deposition profiles. H-mode confinement was also obtained for the first time with 25 MW auxiliary power, of which 10 MW was from ion cyclotron resonance heating. We have used profile measurements of electron temperature T e from electron cyclotron emission and LIDAR Thomson scattering, ion temperature T i from charge-exchange recombination spectroscopy (during NBI), electron density n e from LIDAR and Abel-inverted interferometer measurements. Only sparse information is, however, available to date concerning radial profiles of effective ionic charge and radiation losses. Deuterium depletion due to high impurity levels is an important effect in these discharges, and our interpretation of thermal ion energy content, neutron yield and ion particle fluxes needs to be confirmed using measured Z eff -profiles. (author) 4 refs., 4 figs

  6. Determination of isoorientin levels in rat plasma after oral administration of Vaccinum bracteatum Thunb. methanol extract by high-performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Kim, Min-Ji; Kwon, Seung-Hwan; Jang, Choon-Gon; Maeng, Han-Joo

    2018-01-15

    A simple, sensitive and rapid liquid chromatography tandem mass spectrometry method (LC-MS/MS) was developed and validated for the determination of plasma isoorientin levels in rats. After simple protein precipitation using methanol, chromatographic analysis was performed using a Synergi 4μ polar-RP 80A column (150 × 2.0 mm, 4μm) under isocratic conditions and a mobile phase consisting of 0.1% formic acid in water and methanol (80:20, v/v) at a flow rate of 0.2 mL/min. In positive electrospray ionization mode, the protonated precursor and product ion transitions of isoorientin (m/z 449.0 → 299.1) and of puerarin (the internal standard; m/z 417.1 → 297.1) were acquired by multiple reaction monitoring. Calibration curves obtained for plasma showed good linearity over the concentration range 1-1000 ng/mL. The lower limit of quantification was 1 ng/mL. Intra- and inter-day precisions were within 8.8% relative standard deviation. Accuracies ranged from 92.1 and 109.7%. The isoorientin stability in rat plasma under typical handling/storage conditions also found to be acceptable. The developed method was applied successfully to a pharmacokinetic study of isoorientin orally administered as the methanol extract of Vaccinium bracteatum Thunb. or administered as pure isoorientin. Copyright © 2018 John Wiley & Sons, Ltd.

  7. Proceedings of the third meeting for A3 foresight program workshop on critical physics issues specific to steady state sustainment of high-performance plasmas

    International Nuclear Information System (INIS)

    Hu Liqun; Morita, Shigeru; Oh, Yeong-Kook

    2013-12-01

    To enhance close collaborations among scientists in three Asian countries (China, Japan and Korea), A3 foresight program on Plasma Physics was newly started from August 2012 under the auspice of JSPS (Japan), NRF (Korea) and NSFC (China). The main purpose of this project is to solve several key physics issues through joint experiments on three Asian advanced fully superconducting fusion devices (EAST in China, LHD in Japan and KSTAR in Korea) and other magnetic confinement devices to carry out multi-faceted and complementary physics researches. To summarize the progress and achievement in the first academic year under this A3 foresight program, this workshop was hosted by Institute of Plasma Physics, Chinese Academy of Sciences and held in Beijing during 19-24 May, 2013. Collaborated research and communication with other A3 programs and bilateral programs, as well as participation of young scientists were encouraged in this workshop. The topics include steady state sustainment of magnetic configurations, edge and divertor plasma control and confinement of alpha particles. This issue is the collection of 40 papers presented at the entitled meeting. All the 40 of the presented papers are indexed individually. (J.P.N.)

  8. Proceeding of A3 foresight program seminar on critical physics issues specific to steady state sustainment of high-performance plasmas 2015

    International Nuclear Information System (INIS)

    Hu Liqun; Morita, Shigeru; Oh, Yeong-Kook

    2015-12-01

    To enhance close collaborations among scientists in three Asian countries (China, Japan and Korea), A3 foresight program on Plasma Physics was launched from August 2012 under the auspice of JSPS (Japan), NRF (Korea) and NSFC (China). The main purpose of this project is to solve several key physics issues through joint experiments on three Asian advanced fully superconducting fusion devices (EAST in China, LHD in Japan and KSTAR in Korea) and other magnetic confinement devices to carry out multi-faceted and complementary physics researches. To summarize the progress and achievement in the second academic year under this A3 foresight program, the 6th workshop hosted by Institute of Plasma Physics, Chinese Academy of Sciences was held in Nanning during 6-9 January, 2015. The research collaboration carried out by young scientists was also encouraged with participation of graduated students. The three topics of steady state sustainment of magnetic configurations, edge and divertor plasma control and confinement of alpha particles are mainly discussed in addition to relevant studies in small devices. This issue is the collection of 41 papers presented at the entitled meeting. The 39 of the presented papers are indexed individually. (J.P.N.)

  9. Method optimization and quality assurance in speciation analysis using high performance liquid chromatography with detection by inductively coupled plasma mass spectrometry

    DEFF Research Database (Denmark)

    Larsen, Erik Huusfeldt

    1998-01-01

    Achievement of optimum selectivity, sensitivity and robustness in speciation analysis using high performance liquid chromatography (HPLC) with inductively coupled mass spectrometry (ICP-MS) detection requires that each instrumental component is selected and optimized with a view to the ideal....... The optimized anion and cation exchange HPLC-ICP-MS systems were used for arsenic speciation in contaminated ground water and in an in-house shrimp reference sample. For the purpose of verification, HPLC coupled with tandem mass spectrometry with electrospray ionization was additionally used for arsenic...... a mass balance of the analytes in each fraction of the extraction procedure, by recovery of spikes and by employing and comparing independent techniques. The urgent need for reference materials certified for elemental species is stressed....

  10. Simultaneous determination of chloroquine and its three metabolites in human plasma, whole blood and urine by ion-pair high-performance liquid chromatography.

    Science.gov (United States)

    Houzé, P; de Reynies, A; Baud, F J; Benatar, M F; Pays, M

    1992-02-14

    A method was developed for the separation and measurement of chloroquine and three metabolites (desethylchloroquine, bisdesethylchloroquine and 4-amino-7-chloroquinoline) in biological samples by ion-pair high-performance liquid chromatography with UV detection. The method uses 2,3-diaminoaphthalene as an internal standard and provides a limit of detection between 1 and 2 ng/ml for chloroquine and its metabolites. The assay was linear in the range 12.5-250 ng/ml and the analytical recovery and reproducibility were sufficient. The assay was applied to the analysis of biological samples from a patient undergoing chloroquine chemoprophylaxis and a patient who had ingested chloroquine in a suicide attempt.

  11. Experimental evidence for the suitability of ELMing H-mode operation in ITER with regard to core transport of helium

    International Nuclear Information System (INIS)

    Wade, M.R.; Hillis, D.L.; Burrell, K.H.

    1996-09-01

    Studies have been conducted in DIII-D to assess the viability of the ITER design with regard to helium ash removal, including both global helium exhaust studies and detailed helium transport studies. With respect to helium ash accumulation, the results are encouraging for successful operation of ITER in ELMing H-mode plasmas with conventional high-recycling divertor operation. Helium can be removed from the plasma core with a characteristic time constant of ∼ 8 energy confinement times, even with a central source of helium. Furthermore, the exhaust rate is limited by the pumping efficiency of the system and not by transport of helium within the plasma core. Helium transport studies have shown that D He /X eff ∼ 1 in all confinement regimes studied to date and there is little dependence of D He /X eff on normalized gyroradius in dimensionless scaling studies, suggesting that D He /X eff will be ∼ 1 in ITER. These observations suggest that helium transport within the plasma core should be sufficient to prevent unacceptable fuel dilution in ITER. However, helium exhaust is also strongly dependent on many factors (e.g., divertor plasma conditions, plasma and baffling geometry, flux amplification, pumping speed, etc.) that are difficult to extrapolate. Studies have revealed the helium diffusivity decreases as the plasma density increases, which is unfavorable to ITER's extremely high density operation

  12. Validated High Performance Liquid Chromatography Method for ...

    African Journals Online (AJOL)

    Purpose: To develop a simple, rapid and sensitive high performance liquid ... response, tailing factor and resolution of six replicate injections was < 3 %. ... Cefadroxil monohydrate, Human plasma, Pharmacokinetics Bioequivalence ... Drug-free plasma was obtained from the local .... Influence of probenicid on the renal.

  13. W transport and accumulation control in the termination phase of JET H-mode discharges and implications for ITER

    Science.gov (United States)

    Köchl, F.; Loarte, A.; de la Luna, E.; Parail, V.; Corrigan, G.; Harting, D.; Nunes, I.; Reux, C.; Rimini, F. G.; Polevoi, A.; Romanelli, M.; Contributors, JET

    2018-07-01

    Tokamak operation with W PFCs is associated with specific challenges for impurity control, which may be particularly demanding in the transition from stationary H-mode to L-mode. To address W control issues in this phase, dedicated experiments have been performed at JET including the variation of the decrease of the power and current, gas fuelling and central ion cyclotron heating (ICRH), and applying active ELM control by vertical kicks. The experimental results obtained demonstrate the key role of maintaining ELM control to control the W concentration in the exit phase of H-modes with slow (ITER-like) ramp-down of the neutral beam injection power in JET. For these experiments, integrated fully predictive core+edge+SOL transport modelling studies applying discrete models for the description of transients such as sawteeth and ELMs have been performed for the first time with the JINTRAC suite of codes for the entire transition from stationary H-mode until the time when the plasma would return to L-mode focusing on the W transport behaviour. Simulations have shown that the existing models can appropriately reproduce the plasma profile evolution in the core, edge and SOL as well as W accumulation trends in the termination phase of JET H-mode discharges as function of the applied ICRH and ELM control schemes, substantiating the ambivalent effect of ELMs on W sputtering on one side and on edge transport affecting core W accumulation on the other side. The sensitivity with respect to NB particle and momentum sources has also been analysed and their impact on neoclassical W transport has been found to be crucial to reproduce the observed W accumulation characteristics in JET discharges. In this paper the results of the JET experiments, the comparison with JINTRAC modelling and the adequacy of the models to reproduce the experimental results are described and conclusions are drawn regarding the applicability of these models for the extrapolation of the applied W

  14. High performance conductometry

    International Nuclear Information System (INIS)

    Saha, B.

    2000-01-01

    Inexpensive but high performance systems have emerged progressively for basic and applied measurements in physical and analytical chemistry on one hand, and for on-line monitoring and leak detection in plants and facilities on the other. Salient features of the developments will be presented with specific examples

  15. High performance systems

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, M.B. [comp.

    1995-03-01

    This document provides a written compilation of the presentations and viewgraphs from the 1994 Conference on High Speed Computing given at the High Speed Computing Conference, {open_quotes}High Performance Systems,{close_quotes} held at Gleneden Beach, Oregon, on April 18 through 21, 1994.

  16. Danish High Performance Concretes

    DEFF Research Database (Denmark)

    Nielsen, M. P.; Christoffersen, J.; Frederiksen, J.

    1994-01-01

    In this paper the main results obtained in the research program High Performance Concretes in the 90's are presented. This program was financed by the Danish government and was carried out in cooperation between The Technical University of Denmark, several private companies, and Aalborg University...... concretes, workability, ductility, and confinement problems....

  17. High performance homes

    DEFF Research Database (Denmark)

    Beim, Anne; Vibæk, Kasper Sánchez

    2014-01-01

    . Consideration of all these factors is a precondition for a truly integrated practice and as this chapter demonstrates, innovative project delivery methods founded on the manufacturing of prefabricated buildings contribute to the production of high performance homes that are cost effective to construct, energy...

  18. Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1,2-diamino-4,5-methylenedioxybenzene.

    Science.gov (United States)

    Ogasawara, Yuki; Tanaka, Ryo; Koike, Shin; Horiuchi, Yasue; Miyashita, Mitsuhiro; Arai, Makoto

    2016-09-01

    Methylglyoxal (MG) is a highly reactive dicarbonyl compound that promotes the non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins. The physiological relevance of MG currently remains unclear because its metabolic behavior has not yet been elucidated in detail. Although several labeling methods that require a HPLC system have been developed and used to measure MG, a standard method to analyze the content of MG in biological samples has not been established. We herein present a practical method based on HPLC with fluorescence detection to measure low MG levels. MG concentrations were also measured in human blood plasma using the present method in order to demonstrate its utility. A calibration curve was produced using freshly purified MG at concentrations ranging between 0.05 and 1.0μM. The intra-day and inter-day relative standard diviations of the method were 2.55% and 4.03%, respectively. The limit of detection and limit of quantification were 60fmol and 200fmol, respectively for MG with a 10-μl injection volume of the derivatized sample solution. When the optimized method was applied to human plasma, the resulting concentrations of MG in the plasma of healthy subjects (n=23) ranged between 0.024 and 0.258μM (mean±SD=0.098±0.066). Thus, the method developed herein is simple, sensitive, and easy to operate for the measurement of MG in biological samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Ion-pair vortex assisted liquid-liquid microextraction with back extraction coupled with high performance liquid chromatography-UV for the determination of metformin in plasma.

    Science.gov (United States)

    Alshishani, Anas; Makahleh, Ahmad; Yap, Hui Fang; Gubartallah, Elbaleeq Adam; Salhimi, Salizawati Muhamad; Saad, Bahruddin

    2016-12-01

    A new sample preparation method, ion-pair vortex assisted liquid-liquid microextraction (VALLME-BE), for the determination of a highly polar anti-diabetic drug (metformin) in plasma sample was developed. The VALLME-BE was performed by diluting the plasma in borate buffer and extracted to 150µL 1-octanol containing 0.2M di-(2-ethylhexyl)phosphoric acid as intermediate phase. The drug was next back-extracted into 20µL of 0.075M HCl solution. The effects of pH, ion-pair concentration, type of organic solvent, volume of extraction phases, ionic strength, vortexing and centrifugation times on the extraction efficiency were investigated. The optimum conditions were at pH 9.3, 60s vortexing and 2min centrifugation. The microextract, contained metformin and buformin (internal standard), was directly injected into a HPLC unit using C1 column (250mm×4.6mm×10µm) and detected at 235nm. The method was validated and calibration curve was linear with r 2 >0.99 over the range of 20-2000µgL -1 . The limits of detection and quantitation were 1.4 and 4.1µgL -1 , respectively. The accuracy was within 94.8-108% of the nominal concentration. The relative standard deviation for inter- and intra-day precision was less than 10.8%. The method was conveniently applied for the determination of metformin in plasma samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Measurement of sorafenib plasma concentration by high-performance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? A pilot study.

    Science.gov (United States)

    Fucile, Carmen; Marenco, Simona; Bazzica, Marco; Zuccoli, Maria Laura; Lantieri, Francesca; Robbiano, Luigi; Marini, Valeria; Di Gion, Paola; Pieri, Giulia; Stura, Paola; Martelli, Antonietta; Savarino, Vincenzo; Mattioli, Francesca; Picciotto, Antonino

    2015-01-01

    Pharmacokinetics and dose-finding studies on sorafenib were conducted on heterogeneous groups of patients with solid tumors. Portal hypertension, gut motility impairment and altered bile enterohepatic circulation may explain different sorafenib toxicological profile in cirrhotic patients. This study evaluated sorafenib plasma concentration in a homogeneous group of cirrhotic patients with hepatocellular carcinoma (HCC). Sorafenib concentrations were determined by liquid chromatography in 12 consecutive patients. Data have been evaluated by the generalized estimating equations method (p value statistical level was set at α = 0.05). (1) There were not significant differences between sorafenib concentrations in patients who tolerate the full dose versus patients with reduced dose due to toxicity; (2) the average sorafenib concentrations measured 3 h after the morning dosing were lower than those measured 12 h after the evening dosing (p = 0.005); (3) sorafenib concentrations decrease overtime (p < 10(-4)); (4) it has been found an association between the development of severe adverse reactions and sorafenib concentrations (p < 10(-5)). The relationship between dose and concentration of sorafenib in HCC patients is poor and not clinically predictable, confirming the variability both in the maximum tolerated dose and in plasma concentrations. Several factors may influence the pharmacokinetics in patients with liver disease. This may explain the inter-patient variability of concentrations and the lack of differences in concentration at different dosages. It could be interesting to extend the series of HCC patients to enhance information on the kinetics of the drug; furthermore, to establish a threshold of plasma sorafenib concentrations to predict severe adverse reactions would be clinically useful.

  1. Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry.

    Science.gov (United States)

    Xue, Y J; Pursley, Janice; Arnold, Mark

    2007-04-11

    BMS-299897 is a gamma-secretase inhibitor that is being developed for the treatment of Alzheimer's disease. Liquid-liquid extraction (LLE), chromatographic/tandem mass spectrometry (LC/MS/MS) methods have been developed and validated for the quantitation of BMS-299897 in human plasma and cerebrospinal fluid (CSF). Both methods utilized (13)C6-BMS-299897, the stable label isotope analog, as the internal standard. For the human plasma extraction method, two incubation steps were required after the addition of 5 mM ammonium acetate and the internal standard in acetonitrile to release the analyte bound to proteins prior to LLE with toluene. For the human CSF extraction method, after the addition of 0.5 N HCl and the internal standard, CSF samples were extracted with toluene and no incubation was required. The organic layers obtained from both extraction methods were removed and evaporated to dryness. The residues were reconstituted and injected into the LC/MS/MS system. Chromatographic separation was achieved isocratically on a MetaChem C18 Hypersil BDS column (2.0 mm x 50 mm, 3 microm). The mobile phase contained 10 mM ammonium acetate pH 5 and acetonitrile. Detection was by negative ion electrospray tandem mass spectrometry. The standard curves ranged from 1 to 1000 ng/ml for human plasma and 0.25-100 ng/ml for human CSF. Both standard curves were fitted to a 1/x weighted quadratic regression model. For both methods, the intra-assay precision was within 8.2% CV, the inter-assay precision was within 5.4% CV, and assay accuracy was within +/-7.4% of the nominal values. The validation and sample analysis results demonstrated that both methods had acceptable precision and accuracy across the calibration ranges.

  2. Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography.

    Science.gov (United States)

    Shah, Shailesh A; Rathod, Ishwarsinh S; Suhagia, Bhanubhai N; Patel, Dharmesh A; Parmar, Vijay K; Shah, Bharat K; Vaishnavi, Vikas M

    2007-04-01

    A rapid and sensitive high-performance thin-layer chromatographic (HPTLC) method was developed and validated for the quantitative estimation of boswellic acids in formulation containing Boswellia serrata extract (BSE) and 11-keto beta-boswellic acid in human plasma. Simple extraction method was used for isolation of boswellic acid from formulation sample and acidified plasma sample. The isolated samples were chromatographed on silica gel 60F(254)-TLC plates, developed using ternary-solvent system (hexane-chloroform-methanol, 5:5:0.5, v/v) and scanned at 260 nm. The linearity range for 11-KBA spiked in 1 ml of plasma was 29.15-145.75 ng with average recovery of 91.66%. The limit of detection and limit of quantification for 11-KBA in human plasma were found to be 8.75 ng/ml and 29.15 ng/ml. The developed method was successfully applied for the assay of market formulations containing BSE and to determine plasma level of 11-keto beta-boswellic acid in a clinical pilot study.

  3. Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.

    Science.gov (United States)

    Kusaka, M; Setiabudy, R; Chiba, K; Ishizaki, T

    1996-02-01

    A simple high-performance liquid chromatographic (HPLC) assay method was developed for the measurement of proguanil (PG) and its major metabolites, cycloguanil (CG) and 4-chlorophenyl-biguanide (CPB), in human plasma and urine. The assay allowed the simultaneous determination of all analytes in 1 ml of plasma or 0.1 ml of urine. The detection limits of PG, CG, and CPB, defined as the signal-to-noise ratio of 3, were 1 and 5 ng/ml for plasma and urine samples, respectively. Recoveries of the analytes and the internal standard (pyrimethamine) were > 62% from plasma and > 77% from urine. Intra-assay and interassay coefficients of variation for all analytes in plasma and urine were CG and CPB, which ranged from 10% to 15% at one or two concentrations among 4-5 concentrations studied. The clinical applicability of the method was assessed by the preliminary pharmacokinetic study of PG, CG, and CPB in six healthy volunteers with the individually known phenotypes (extensive and poor metabolizers) of S-mephenytoin 4'-hydroxylation, suggesting that individuals with a poor metabolizer phenotype of S-mephenytoin have a much lower capacity to bioactivate PG to CG compared with the extensive metabolizers.

  4. Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode.

    Science.gov (United States)

    Sugimoto, Hiroshi; Kakehi, Masaaki; Satomi, Yoshinori; Kamiguchi, Hidenori; Jinno, Fumihiro

    2015-10-01

    We developed a highly sensitive and specific high-performance liquid chromatography with tandem mass spectrometry method with an atmospheric pressure chemical ionization interface to determine 24S-hydroxycholesterol, a major metabolite of cholesterol formed by cytochrome P450 family 46A1, in human plasma without any derivatization step. Phosphate buffered saline including 1% Tween 80 was used as the surrogate matrix for preparation of calibration curves and quality control samples. The saponification process to convert esterified 24S-hydroxycholesterol to free sterols was optimized, followed by liquid-liquid extraction using hexane. Chromatographic separation of 24S-hydroxycholesterol from other isobaric endogenous oxysterols was successfully achieved with gradient mobile phase comprised of 0.1% propionic acid and acetonitrile using L-column2 ODS (2 μm, 2.1 mm id × 150 mm). This assay was capable of determining 24S-hydroxycholesterol in human plasma (200 μL) ranging from 1 to 100 ng/mL with acceptable intra- and inter-day precision and accuracy. The potential risk of in vitro formation of 24S-hydroxycholesterol by oxidation from endogenous cholesterol in human plasma was found to be negligible. The stability of 24S-hydroxycholesterol in relevant solvents and human plasma was confirmed. This method was successfully applied to quantify the plasma concentrations of 24S-hydroxycholesterol in male and female volunteers. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Formation of an internal transport barrier in the ohmic H-mode in the TUMAN-3M tokamak

    International Nuclear Information System (INIS)

    Andrejko, M.V.; Askinazi, L.G.; Golant, V.E.; Zhubr, N.A.; Kornev, V.A.; Krikunov, S.V.; Lebedev, S.V.; Levin, L.S.; Razdobarin, G.T.; Rozhdestvensky, V.V.; Smirnov, A.I.; Tukachinsky, A.S.; Yaroshevich, S.P.

    2000-01-01

    In experiments on studying the ohmic H-mode in the TUMAN-3M tokamak, it is found that, in high-current (I p ∼ 120-170 kA) discharges, a region with high electron-temperature and density gradients is formed in the plasma core. In this case, the energy confinement time τ E attains 9-18 ms, which is nearly twice as large as that predicted by the ELM-free ITER-93H scaling. This is evidence that the internal transport barrier in a plasma can exist without auxiliary heating. Calculations of the effective thermal diffusivity by the ASTRA transport code demonstrate a strong suppression of heat transport in the region where the temperature and density gradients are high

  6. PEEK tube-based online solid-phase microextraction-high-performance liquid chromatography for the determination of yohimbine in rat plasma and its application in pharmacokinetics study.

    Science.gov (United States)

    Xiang, Xiaowei; Shang, Bing; Wang, Xiaozheng; Chen, Qinhua

    2017-04-01

    Yohimbine is a novel compound for the treatment of erectile dysfunction derived from natural products, and pharmacokinetic study is important for its further development as a new medicine. In this work, we developed a novel PEEK tube-based solid-phase microextraction (SPME)-HPLC method for analysis of yohimbine in plasma and further for pharmacokinetic study. Poly (AA-EGDMA) was synthesized inside a PEEK tube as the sorbent for microextraction of yohimbine, and parameters that could influence extraction efficiency were systematically investigated. Under optimum conditions, the PEEK tube-based SPME method exhibits excellent enrichment efficiency towards yohimbine. By using berberine as internal standard, an online SPME-HPLC method was developed for analysis of yohimbine in human plasma sample. The method has wide linear range (2-1000 ng/mL) with an R 2 of 0.9962; the limit of detection was determined and was as low as 0.1 ng/mL using UV detection. Finally, a pharmacokinetic study of yohimbine was carried out by the online SPME-HPLC method and the results have been compared with those of reported methods. Copyright © 2016 John Wiley & Sons, Ltd.

  7. High-performance liquid chromatographic determination of certain salicylates and their major metabolites in plasma following topical administration of a liniment to healthy subjects.

    Science.gov (United States)

    Dadgar, D; Climax, J; Lambe, R; Darragh, A

    1985-08-09

    The liniment used is a topical analgesic and anti-inflammatory preparation containing two active constituents, 3-phenylpropylsalicylate and ethyl-5-methoxysalicylate, in solution in isobutyl decanoate. It is known that 3-phenylpropylsalicylate is metabolised to salicylic acid and salicyluric acid and ethyl-5-methoxysalicylate is metabolised to 5-methoxysalicylic acid and gentisic acid. In the present study the separation of the salicylates and their metabolites was carried out on a Waters mu Bondapak C18 column using two different mobile phases, methanol-water (80:20) for the parent drugs and methanol-5% aqueous acetic acid (27:73) for their metabolites. The salicylates and their metabolites were detected by absorption at 310 nm. The limits of detection for parent drugs and metabolites were respectively 0.2 and 0.1 microgram/ml in plasma, using a 1-ml plasma sample and a 20-microliter injection from a reconstituted volume of 250 microliter. Mean percentage coefficients of variation for intra-assay and inter-assay precision were between 3.3 +/- 1.9% to 9.1 +/- 3.7% and 6.8 +/- 2.2% to 15.7 +/- 10.1%, respectively. Linearity, as measured by the correlation coefficient of intra-assay linear regression curves, was better than 0.998 in all cases.

  8. Simple O2 Plasma-Processed V2O5 as an Anode Buffer Layer for High-Performance Polymer Solar Cells

    DEFF Research Database (Denmark)

    Bao, Xichang; Zhu, Qianqian; Wang, Ting

    2015-01-01

    A simple O2 plasma processing method for preparation of a vanadium oxide (V2O5) anode buffer layer on indium tin oxide (ITO)-coated glass for polymer solar cells (PSCs) is reported. The V2O5 layer with high transmittance and good electrical and interfacial properties was prepared by spin coating...... the illumination of AM 1.5G (100 mW/cm2). Compared to that of the control device with PBDTTT-C:PC71BM as the active layer and PEDOT:PSS (PCE of 6.52%) and thermally annealed V2O5 (PCE of 6.27%) as the anode buffer layer, the PCE was improved by 15.6 and 20.2%, respectively, after the introduction of a V2O5 (O2...... plasma) anode buffer layer. The improved PCE is ascribed to the greatly improved fill factor and enhanced short-circuit current density of the devices, which benefited from the change in the work function of V2O5, a surface with many dangling bonds for better interfacial contact, and the excellent charge...

  9. Determination of asperosaponin VI in dog plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pilot pharmacokinetic study.

    Science.gov (United States)

    Shakya, Shailendra; Zhu, He; Ding, Li; Du, Xiao Lang; Qi, Xie Min; Yang, Xiao Lin; Yang, Zhong Lin

    2012-01-01

    A sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of asperosaponin VI in beagle dog plasma using glycyrrhizic acid as the internal standard (IS). Plasma samples were simply pretreated with methanol for deproteinization. Chromatographic separation was performed on a Hedera ODS-2 column using mobile phase of methanol-10 mm ammonium acetate buffer solution containing 0.05% acetic acid (71:29, v/v) at a flow rate of 0.38 mL/min. Asperosaponin VI and the IS were eluted at 2.8 and 1.9 min, respectively, ionized in negative ion mode, and then detected by multiple reaction monitoring. The detection used the transitions of the deprotonated molecules at m/z 927.5 → 603.4 for asperosaponin VI and m/z 821.4 → 645.4 for glycyrrhizic acid (IS). The assay was linear over the concentration range of 0.15-700 ng/mL and was successfully applied to a pilot pharmacokinetic study in beagle dogs. Copyright © 2011 John Wiley & Sons, Ltd.

  10. Simultaneous determination of 7-O-succinyl macrolactin A and its active major metabolite, macrolactin A in dog plasma using high-performance liquid chromatography with UV detection.

    Science.gov (United States)

    Kim, Eunyoung; Shin, Beomsoo; Kwon, Kwang-il; Bang, Joon Seok; Kang, Wonku

    2014-10-01

    We developed a method for the simultaneous quantification of 7-O-succinyl macrolactin A and its active metabolite, macrolactin A, in dog plasma. After protein precipitation with acetonitrile including flufenamic acid as an internal standard, 7-O-succinyl macrolactin A, macrolactin A, and flufenamic acid were chromatographed on a reverse-phase C18 analytical column. The mobile phase, consisting of 20 mM acetate buffer and acetonitrile, was eluted using a gradient program at 1 mL/min, and the UV absorbance was measured at 230 nm. The retention times of 7-O-succinyl macrolactin A, flufenamic acid, and macrolactin A were 3.4, 4.8, and 6.9 min, respectively. The coefficient of variation in the assay precision for both substances was less than 6%, and the accuracy ranged from 96 to 105%. This method was used to measure the concentrations of 7-O-succinyl macrolactin A and macrolactin A in dog plasma following an intravenous administration of a single dose (25 mg/kg) of 7-O-succinyl macrolactin A salt. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Determination of rivaroxaban in patient’s plasma samples by anti-Xa chromogenic test associated to High Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS)

    Science.gov (United States)

    Derogis, Priscilla Bento Matos; Sanches, Livia Rentas; de Aranda, Valdir Fernandes; Colombini, Marjorie Paris; Mangueira, Cristóvão Luis Pitangueira; Katz, Marcelo; Faulhaber, Adriana Caschera Leme; Mendes, Claudio Ernesto Albers; Ferreira, Carlos Eduardo dos Santos; França, Carolina Nunes; Guerra, João Carlos de Campos

    2017-01-01

    Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure rivaroxaban plasmatic concentration. Our method used a simple sample preparation, protein precipitation, and a fast chromatographic run. It was developed a precise and accurate method, with a linear range from 2 to 500 ng/mL, and a lower limit of quantification of 4 pg on column. The new method was compared to a reference method (anti-factor Xa activity) and both presented a good correlation (r = 0.98, p highly correlated and should be used as clinical tools for drug monitoring. The method was applied successfully in a group of 49 real-life patients, which allowed an accurate determination of rivaroxaban in peak and trough levels. PMID:28170419

  12. Thermo-mechanical and damage analyses of EAST carbon divertor under type-I ELMy H-mode operation

    Energy Technology Data Exchange (ETDEWEB)

    Li, W.X. [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China); Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Song, Y.T. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China); Ye, M.Y. [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China); Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Peng, X.B., E-mail: pengxb@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wu, S.T. [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China); Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Qian, X.Y.; Zhu, C.C. [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China)

    2016-04-15

    Highlights: • Type-I ELMy H-mode is one of the most severe operating environment in tokamak. • An actual time-history heat load has been used in thermo-mechanical analysis. • The analysis results are time-dependent during the whole discharge process. • The analysis could be very useful in evaluating the operational capability of the divertor. - Abstract: The lower carbon divertor has been used since 2008 in EAST, and many significant physical results, like the 410 s long pulse discharge and the 32 s H-mode operation, have been achieved. As the carbon divertor will still be used in the next few years while the injected auxiliary heating power would be increased gradually, it’s necessary to evaluate the operational capability of the carbon divertor under the heat loads during future operation. In this paper, an actual time-history heat load during type-I ELMy H-mode from EAST experiment, as one of the most severe operating environment in tokamak, has been used in the calculation and analysis. The finite element (FE) thermal and mechanical calculations have been carried out to analysis the stress and deformation of the carbon divertor during the heat loads. According to the results, the main impact on the overall temperature comes from the relative stable phase before and after the type-I ELMs and local peak load, and the transient thermal load such as type-I ELMy only has a significant effect on the surface temperature of the graphite tiles. The carbon divertor would work with high stress near the screw bolts in the current operational conditions, because of high preload and conservative frictional coefficient between the bolts and heatsink. For the future operation, new plasma facing materials (PFM) and divertor technology should be developed.

  13. New features of L-H transition in limiter H-modes of JIPP T-IIU

    International Nuclear Information System (INIS)

    Toi, K.; Morita, S.; Kawahata, K.

    1992-09-01

    In limiter H-modes of JIPP T-IIU, a new type of L-H transition preceded by an ELM is observed. The preceding ELM (pre-ELM) appears just prior to the L-H transition. This type of transition is usually observed in H-modes of JIPP T-IIU. The L-H transition without the pre-ELM is triggered only in the case when a sufficiently large rapid current ramp down is emploied. In H-modes with constant q(a)∼3.5-4.5, coherent magnetic oscillations with m=3/n=1 destabilized during L-phase are further enhanced at the pre-ELM, and suppressed suddenly at the transition. This mode is situated in the region of the transport barrier. Propagation frequency of the m=3/n=1 mode, which may be affected by plasma mass rotation, rises appreciably (by ∼ 10 %) during H-phase with frequent ELMs, but remains unchanged for at least 200 μs after the transition. Behaviours of the m=3/n=1 and m=2/n=1 modes are well explained by quasi-linear resistive tearing mode analysis for modelled toroidal current density profiles slightly detached from the limiter. These experimental results suggest that the transition is controlled by the change of a magnetic field structure relating to the modification of a toroidal current density profile near the edge. The possibility for the development of edge radial electric field as a consequence of the transition is discussed. (author)

  14. Long sustainment of quasi-steady-state high βp H mode discharges in JT-60U

    International Nuclear Information System (INIS)

    Isayama, A.; Kamada, Y.; Ozeki, T.; Ide, S.; Fujita, T.; Oikawa, T.; Suzuki, T.; Neyatani, Y.; Isei, N.; Hamamatsu, K.; Ikeda, Y.; Takahashi, K.; Kajiwara, K.

    2001-01-01

    Quasi-steady-state high β p H mode discharges performed by suppressing neoclassical tearing modes (NTMs) are described. Two operational scenarios have been developed for long sustainment of the high β p H mode discharge: NTM suppression by profile optimization, and NTM stabilization by local electron cyclotron current drive (ECCD)/electron cyclotron heating (ECH) at the magnetic island. Through optimization of pressure and safety factor profiles, a high β p H mode plasma with H 89PL = 2.8, HH y,2 = 1.4, β p ∼ 2.0 and β N ∼ 2.5 has been sustained for 1.3 s at small values of collisionality ν e* and ion Larmor radius ρ i* without destabilizing the NTMs. Characteristics of the NTMs destabilized in the region with central safety factor above unity are investigated. The relation between the beta value at the mode onset β N on and that at the mode disappearance β N off can be described as β N off /β N on =0.05-0.4, which shows the existence of hysteresis. The value of β N /ρ i* at the onset of an m/n = 3/2 NTM has a collisionality dependence, which is empirically given by β N /ρ i* ∝ ν e* 0.36 . However, the profile effects such as the relative shapes of pressure and safety factor profiles are equally important. The onset condition seems to be affected by the strength of the pressure gradient at the mode rational surface. Stabilization of the NTM by local ECCD/ECH at the magnetic island has been attempted. A 3/2 NTM has been completely stabilized by EC wave injection of 1.6 MW. (author)

  15. Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat.

    Science.gov (United States)

    Italiya, Kishan S; Sharma, Saurabh; Kothari, Ishit; Chitkara, Deepak; Mittal, Anupama

    2017-09-01

    Lisofylline (LSF) is an anti-inflammatory and immunomodulatory agent with proven activity in serious infections associated with cancer chemotherapy, hyperoxia-induced acute lung injury, autoimmune disorders including type-1 diabetes (T1DM) and islet rejection after islet transplantation. It is also an active metabolite of another anti-inflammatory agent, Pentoxifylline (PTX). LSF bears immense therapeutic potential in multiple pharmacological activities and hence appropriate and accurate quantification of LSF is very important. Although a number of analytical methods for quantification of LSF and PTX have been reported for pharmacokinetics and metabolic studies, each of these have certain limitations in terms of large sample volume required, complex extraction procedure and/or use of highly sophisticated instruments like LC-MS/MS. The aim of current study is to develop a simple reversed-phase HPLC method in rat plasma for simultaneous determination of LSF and PTX with the major objective of ensuring minimum sample volume, ease of extraction, economy of analysis, selectivity and avoiding use of instruments like LC-MS/MS to ensure a widespread application of the method. A simple liquid-liquid extraction method using methylene chloride as extracting solvent was used for extracting LSF and PTX from rat plasma (200μL). Samples were then evaporated, reconstituted with mobile phase and injected into HPLC coupled with photo-diode detector (PDA). LSF, PTX and 3-isobutyl 1-methyl xanthine (IBMX, internal standard) were separated on Inertsil® ODS (C18) column (250×4.6mm, 5μm) with mobile phase consisting of A-methanol B-water (50:50v/v) run in isocratic mode at flow rate of 1mL/min for 15min and detection at 273nm. The method showed linearity in the concentration range of 50-5000ng/mL with LOD of 10ng/mL and LLOQ of 50ng/mL for both LSF and PTX. Weighted linear regression analysis was also performed on the calibration data. The mean absolute recoveries were found to be 80

  16. High-performance Ag0.8Pb18+xSbTe20 thermoelectric bulk materials fabricated by mechanical alloying and spark plasma sintering

    International Nuclear Information System (INIS)

    Wang Heng; Li Jingfeng; Nan Cewen; Zhou Min; Liu Weishu; Zhang Boping; Kita, Takuji

    2006-01-01

    Polycrystalline Ag n Pb m SbTe m+2n thermoelectric materials, whose compositions can be described as Ag 0.8 Pb 18+x SbTe 20 were prepared using a combined process of mechanical alloying and spark plasma sintering. Electric properties of the sintered samples with different Pb contents were measured from room temperature to 700 K. The maximum power factor of 1.766 mW/mK 2 was obtained at 673 K for the Ag 0.8 Pb 22 SbTe 20 sample, which corresponds to a high dimensionless figure of merit, ZT=1.37. This best composition is different from that reported before

  17. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study.

    Science.gov (United States)

    Abdallah, Inas A; Huang, Peng; Liu, Jing; Lee, David Y; Liu-Chen, Lee-Yuan; Hassan, Hazem E

    2017-04-01

    Levo-tetrahydropalmatine (l-THP) is an alkaloid isolated from Chinese medicinal herbs of the Corydalis and Stephania genera. It has been used in China for more than 40 years mainly as an analgesic with sedative/hypnotic effects. Despite its extensive use, its metabolism has not been quantitatively studied, nor there a sensitive reliable bioanalytical method for its quantification simultaneously with its metabolites. As such, the objective of this study was to develop and validate a sensitive and selective HPLC method for simultaneous quantification of l-THP and its desmethyl metabolites l-corydalmine (l-CD) and l-corypalmine (l-CP) in rat plasma and brain tissues. Rat plasma and brain samples were processed by liquid-liquid extraction using ethyl acetate. Chromatographic separation was achieved on a reversed-phase Symmetry® C 18 column (4.6 × 150 mm, 5 μm) at 25°C. The mobile phase consisted of acetonitrile-methanol-10 mm ammonium phosphate (pH 3) (10:30:60, v/v) and was used at a flow rate of 0.8 mL/min. The column eluent was monitored at excitation and emission wavelengths of 230 and 315 nm, respectively. The calibration curves were linear over the concentration range of 1-10,000 ng/mL. The intra- and interday reproducibility studies demonstrated accuracy and precision within the acceptance criteria of bioanalytical guidelines. The validated HPLC method was successfully applied to analyze samples from a pharmacokinetic study of l-THP in rats. Taken together, the developed method can be applied for bioanalysis of l-THP and its metabolites in rodents and potentially can be transferred for bioanalysis of human samples. Copyright © 2016 John Wiley & Sons, Ltd.

  18. Ultra high performance liquid chromatography-quadrupole-time of flight analysis for the identification and the determination of resveratrol and its metabolites in mouse plasma

    International Nuclear Information System (INIS)

    Menet, M.C.; Cottart, C.H.; Taghi, M.; Nivet-Antoine, V.; Dargère, D.

    2013-01-01

    Graphical abstract: Simultaneous identification and determination of new resveratrol metabolites in mice by UHPLC-Q-TOF in full scan mode. Highlights: ► Fast method to quantify resveratrol and its main metabolites in the mouse plasma. ► Isotope-labeled standards to build a linear calibration curve. ► Linear calibration curve on a wide range of concentrations. ► Simultaneous identification and quantification of metabolites by using full scan mode. ► Detection of uncommon metabolites not yet described in mice. - Abstract: Resveratrol is a polyphenol that has numerous interesting biological properties, but, per os, it is quickly metabolized. Some of its metabolites are more concentrated than resveratrol, may have greater biological activities, and may act as a kind of store for resveratrol. Thus, to understand the biological impact of resveratrol on a physiological system, it is crucial to simultaneously analyze resveratrol and its metabolites in plasma. This study presents an analytical method based on UHPLC-Q-TOF mass spectrometry for the quantification of resveratrol and of its most common hydrophilic metabolites. The use of 13 C- and D-labeled standards specific to each molecule led to a linear calibration curve on a larger concentration range than described previously. The use of high resolution mass spectrometry in the full scan mode enabled simultaneous identification and quantification of some hydrophilic metabolites not previously described in mice. In addition, UHPLC separation, allowing run times lower than 10 min, can be used in studies that requiring analysis of many samples.

  19. Ultra high performance liquid chromatography-quadrupole-time of flight analysis for the identification and the determination of resveratrol and its metabolites in mouse plasma

    Energy Technology Data Exchange (ETDEWEB)

    Menet, M.C., E-mail: marie-claude.menet@parisdescartes.fr [Universite Paris Descartes, Sorbonne Paris cite, EA 4463, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l' Observatoire, Paris 75270 (France); Cottart, C.H. [APHP, Groupe hospitalier Pitie-Salpetriere, Charles Foix, Service de Biochimie, 7 avenue de la Republique, Ivry sur Seine 94205 (France); Universite Paris Descartes, Sorbonne Paris cite, EA 4466, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l' Observatoire, Paris 75270 (France); Taghi, M. [Universite Paris Descartes, Sorbonne Paris cite, EA 4463, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l' Observatoire, Paris 75270 (France); Nivet-Antoine, V. [Universite Paris Descartes, Sorbonne Paris cite, EA 4466, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l' Observatoire, Paris 75270 (France); APHP, Hopital Europeen Georges Pompidou, Service de Biochimie, 20 rue Leblanc, Paris 75015 (France); Dargere, D. [Universite Paris Descartes, Sorbonne Paris cite, EA 4463, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l' Observatoire, Paris 75270 (France); and others

    2013-01-25

    Graphical abstract: Simultaneous identification and determination of new resveratrol metabolites in mice by UHPLC-Q-TOF in full scan mode. Highlights: Black-Right-Pointing-Pointer Fast method to quantify resveratrol and its main metabolites in the mouse plasma. Black-Right-Pointing-Pointer Isotope-labeled standards to build a linear calibration curve. Black-Right-Pointing-Pointer Linear calibration curve on a wide range of concentrations. Black-Right-Pointing-Pointer Simultaneous identification and quantification of metabolites by using full scan mode. Black-Right-Pointing-Pointer Detection of uncommon metabolites not yet described in mice. - Abstract: Resveratrol is a polyphenol that has numerous interesting biological properties, but, per os, it is quickly metabolized. Some of its metabolites are more concentrated than resveratrol, may have greater biological activities, and may act as a kind of store for resveratrol. Thus, to understand the biological impact of resveratrol on a physiological system, it is crucial to simultaneously analyze resveratrol and its metabolites in plasma. This study presents an analytical method based on UHPLC-Q-TOF mass spectrometry for the quantification of resveratrol and of its most common hydrophilic metabolites. The use of {sup 13}C- and D-labeled standards specific to each molecule led to a linear calibration curve on a larger concentration range than described previously. The use of high resolution mass spectrometry in the full scan mode enabled simultaneous identification and quantification of some hydrophilic metabolites not previously described in mice. In addition, UHPLC separation, allowing run times lower than 10 min, can be used in studies that requiring analysis of many samples.

  20. Identification and quantification of glucosamine in rabbit cartilage and correlation with plasma levels by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

    International Nuclear Information System (INIS)

    Pastorini, Elisabetta; Vecchiotti, Stefania; Colliva, Carolina; Persiani, Stefano; Rotini, Roberto; Roatti, Giulia; Zaccarelli, Lorenzo; Rovati, Lucio Claudio; Roda, Aldo

    2011-01-01

    Graphical abstract: Highlights: → Optimization of an HPLC-ESI-MS/MS method for glucosamine in rabbit cartilage. → Application of the method to an in-vivo study. → Glucosamine presence in cartilage in physiological condition. → Significant increase of cartilage glucosamine concentration after dosing. → Good correlation between cartilage glucosamine levels and plasma concentrations. - Abstract: A new HPLC-ESI-MS/MS method for the determination of glucosamine (2-amino-2-deoxy-D-glucose) in rabbit cartilage was developed and optimized. Glucosamine was extracted from cartilage by cryogenic grinding followed by protein precipitation with trichloroacetic acid. The HPLC separation was achieved with a polymer-based amino column using a mobile phase composed of 10 mM ammonium acetate (pH 7.5)-acetonitrile (20:80%, v/v) at 0.3 mL min -1 flow rate. D-[1- 13 C]Glucosamine was used as internal standard. Selective detection was performed by tandem mass spectrometry with electrospray source, operating in positive ionization mode and in multiple reaction monitoring acquisition (m/z 180 → 72 and 181 → 73 for glucosamine and internal standard, respectively). Limit of quantification was 0.045 ng injected, corresponding to 0.25 μg g -1 in cartilage. Linearity was obtained up to 20 μg g -1 (R 2 > 0.991). Precision values (%R.S.D.) were -1 (n = 6). Glucosamine was present in cartilage in physiological condition before the treatment. After dosing, mean concentration of cartilage glucosamine significantly increased from 461 to 1040 ng g -1 . Cartilage glucosamine levels resulted to be well correlated with plasma concentrations, which therefore are useful to predict the target cartilage concentration and its pharmacological activity.

  1. Speciation of the bio-available iodine and bromine forms in edible seaweed by high performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry

    International Nuclear Information System (INIS)

    Romarís-Hortas, Vanessa; Bermejo-Barrera, Pilar; Moreda-Piñeiro, Jorge; Moreda-Piñeiro, Antonio

    2012-01-01

    Highlights: ► Bioavailable iodine and bromine speciation in edible seaweed were developed. ► In vitro dialyzability was used to assess the bioavailable fractions. ► AEC hyphenated with inductively coupled plasma-mass spectrometry was used. ► Iodide, MIT, DIT, bromide and bromate were found in dialyzates from edible seaweed. ► Positive correlation between bioavailability and protein contents was found. - Abstract: A bioavailability study based on an in vitro dialyzability approach has been applied to assess the bio-available fractions of iodine and bromine species from edible seaweed. Iodide, iodate, 3-iodo-tyrosine (MIT), 3,5-diiodo-tyrosine (DIT), bromide and bromate were separated by anion exchange chromatography under a gradient elution mode (175 mM ammonium nitrate plus 15% (v/v) methanol, pH 3.8, as a mobile phase, and flow rates within the 0.5–1.5 mL min −1 range). Inductively coupled plasma-mass spectrometry (ICP-MS) was used as a selective detector for iodine ( 127 I) and bromine ( 79 Br). Low dialyzability ratios (within the 2.0–18% range) were found for iodine species; whereas, moderate dialyzability percentages (from 9.0 to 40%) were obtained for bromine species. Iodide and bromide were the major species found in the dialyzates from seaweed, although MIT and bromate were also found in the dialyzates from most of the seaweed samples analysed. However, DIT was only found in dialyzates from Wakame, Kombu, and NIES 09 (Sargasso) certified reference material; whereas, iodate was not found in any dialyzate. Iodine dialyzability was found to be dependent on the protein content (negative correlation), and on the carbohydrate and dietary fibre levels (positive correlation). However, bromine dialyzability was only dependent on the protein amount in seaweed (negative correlation).

  2. High-Performance Networking

    CERN Multimedia

    CERN. Geneva

    2003-01-01

    The series will start with an historical introduction about what people saw as high performance message communication in their time and how that developed to the now to day known "standard computer network communication". It will be followed by a far more technical part that uses the High Performance Computer Network standards of the 90's, with 1 Gbit/sec systems as introduction for an in depth explanation of the three new 10 Gbit/s network and interconnect technology standards that exist already or emerge. If necessary for a good understanding some sidesteps will be included to explain important protocols as well as some necessary details of concerned Wide Area Network (WAN) standards details including some basics of wavelength multiplexing (DWDM). Some remarks will be made concerning the rapid expanding applications of networked storage.

  3. High Performance Concrete

    Directory of Open Access Journals (Sweden)

    Traian Oneţ

    2009-01-01

    Full Text Available The paper presents the last studies and researches accomplished in Cluj-Napoca related to high performance concrete, high strength concrete and self compacting concrete. The purpose of this paper is to raid upon the advantages and inconveniences when a particular concrete type is used. Two concrete recipes are presented, namely for the concrete used in rigid pavement for roads and another one for self-compacting concrete.

  4. High performance polymeric foams

    International Nuclear Information System (INIS)

    Gargiulo, M.; Sorrentino, L.; Iannace, S.

    2008-01-01

    The aim of this work was to investigate the foamability of high-performance polymers (polyethersulfone, polyphenylsulfone, polyetherimide and polyethylenenaphtalate). Two different methods have been used to prepare the foam samples: high temperature expansion and two-stage batch process. The effects of processing parameters (saturation time and pressure, foaming temperature) on the densities and microcellular structures of these foams were analyzed by using scanning electron microscopy

  5. Quantification of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet detector (HPLC-UV): application to pharmacokinetic studies in 28 healthy Korean subjects.

    Science.gov (United States)

    Kim, Mi-Sun; Park, Yoo-Sin; Kim, Shin-Hee; Kim, Sang-Yeon; Lee, Min-Ho; Kim, Youn-Hee; Kim, Do-Wan; Yang, Seok-Chul; Kang, Ju-Seop

    2012-05-01

    Nimesulide is a selective COX-2 inhibitor that is as effective as the classical non-acidic nonsteroidal anti-inflammatory drugs in the relief of various pain and inflammatory conditions, but is better tolerated with lower incidences of adverse effects than other drugs. After oral dose of 100 mg nimesulide to western subjects, a mean maximal concentration (C(max)) of 2.86 ∼ 6.5 µg/mL was reached at 1.22 ∼ 2.75 h and mean t(1/2β) of 1.8 ∼ 4.74 h. This study developed a robust method for quantification of nimesulide for the pharmacokinetics and suitability of its dosage in Korea and compared its suitability with other racial populations. Nimesulide and internal standard were extracted from acidified samples with methyl tert-butyl ether and analyzed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The 28 healthy volunteers took 2 tablets of 100 mg nimesulide and blood concentrations were analyzed during the 24 h post dose. Several pharmacokinetic parameters were represented: AUC(0-infinity) = 113.0 mg-h/mL, C(max) = 12.06 mg/mL, time for maximal concentrations (T(max)) = 3.19 h and t(1/2β) = 4.51 h. These were different from those of western populations as follows: AUC was 14.5% and C(max) was 28% that of of Korean subjects and T(max) and t(1/2β) were also different. The validated HPLC-UV method was successfully applied for the pharmacokinetic studies of nimesulide in Korean subjects. Because the pharmacokinetics of nimesulide were different from western populations, its dosage regimen needs to be adjusted for Koreans. © The Author [2012]. Published by Oxford University Press. All rights reserved.

  6. Unbiased Scanning Method and Data Banking Approach Using Ultra-High Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry for Quantitative Comparison of Metabolite Exposure in Plasma across Species Analyzed at Different Dates.

    Science.gov (United States)

    Gao, Hongying; Deng, Shibing; Obach, R Scott

    2015-12-01

    An unbiased scanning methodology using ultra high-performance liquid chromatography coupled with high-resolution mass spectrometry was used to bank data and plasma samples for comparing the data generated at different dates. This method was applied to bank the data generated earlier in animal samples and then to compare the exposure to metabolites in animal versus human for safety assessment. With neither authentic standards nor prior knowledge of the identities and structures of metabolites, full scans for precursor ions and all ion fragments (AIF) were employed with a generic gradient LC method to analyze plasma samples at positive and negative polarity, respectively. In a total of 22 tested drugs and metabolites, 21 analytes were detected using this unbiased scanning method except that naproxen was not detected due to low sensitivity at negative polarity and interference at positive polarity; and 4'- or 5-hydroxy diclofenac was not separated by a generic UPLC method. Statistical analysis of the peak area ratios of the analytes versus the internal standard in five repetitive analyses over approximately 1 year demonstrated that the analysis variation was significantly different from sample instability. The confidence limits for comparing the exposure using peak area ratio of metabolites in animal plasma versus human plasma measured over approximately 1 year apart were comparable to the analysis undertaken side by side on the same days. These statistical analysis results showed it was feasible to compare data generated at different dates with neither authentic standards nor prior knowledge of the analytes.

  7. Development of a confirmatory method for detecting recombinant bovine somatotropin in plasma by immunomagnetic precipitation followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry.

    Science.gov (United States)

    Robert, Christelle; Huet, Anne-Catherine; Suárez-Pantaleón, Célia; Brasseur, Amaury; Delahaut, Philippe; Gillard, Nathalie

    2017-11-01

    Recombinant bovine somatotropin (rbST), a synthetic growth hormone, is used to stimulate growth and enhance milk production in dairy cows. Both its use and the sale of dairy products from treated animals are prohibited in the European Union, as well as in Australia, Canada, Japan, and New Zealand, but authorised in several countries (e.g. Brazil, USA). Screening methods involve detecting anti-rbST antibodies (biomarkers) in treated cows. Confirmatory methods are required to prove rbST abuse. The major challenges in determining rbST are its potentially low levels, its high similarity to native bST, and matrix interferences. To overcome these obstacles, we have developed a method involving immunomagnetic precipitation followed by UHPLC-MS/MS for rbST detection. Briefly, protein G magnetic beads pre-coated with an in-house produced monoclonal antibody were added to plasma. Incubation at room temperature allowed rbST present in the sample to bind to the magnetic beads. After that, magnetic beads were isolated by centrifugation and thoroughly washed (PBS, PBS + 0.2% Tween 20). Finally, rbST was released by alkalinisation and the samples were trypsin digested prior to UHPLC-MS/MS analysis in the MRM mode. Validation was done in accordance with European Commission Decision 2002/657/CE. Matrix-matched calibration with internal standards was used. The decision limit (CCα) reached with this approach was 0.11 µg l -1 .

  8. Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study.

    Science.gov (United States)

    Hu, Ziyan; Zou, Qiaogen; Tian, Jixin; Sun, Lili; Zhang, Zunjian

    2011-12-15

    A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma has been developed and validated. Following liquid-liquid extraction, the analytes were separated on a reversed-phase C(18) column (150 mm × 2.0 mm, 3 μm) using formic acid:10 mM ammonium acetate:methanol (0.2:62:38, v/v/v) as mobile phase at a flow rate of 0.2 mL/min and analyzed by a triple-quadrupole mass spectrometer in the selected reaction monitoring (SRM) mode. The method was linear for all analytes over the following concentration (ng/mL) ranges: codeine 0.08-16; ephedrine 0.8-160; guaiphenesin 80-16,000; chlorpheniramine 0.2-40. Acceptable precision and accuracy were obtained for concentrations over the standard curve range. It is the first time that the validated HPLC-MS/MS method was successfully applied to a bioequivalence study in 6 healthy beagle dogs. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Three-dimensional (3D) plasma micro-nanotextured slides for high performance biomolecule microarrays: Comparison with epoxy-silane coated glass slides.

    Science.gov (United States)

    Tsougeni, Katerina; Ellinas, Kosmas; Koukouvinos, George; Petrou, Panagiota S; Tserepi, Angeliki; Kakabakos, Sotirios E; Gogolides, Evangelos

    2018-05-01

    Glass slides coated with a poly(methyl methacrylate) layer and plasma micro-nanotextured to acquire 3D topography (referred as 3D micro-nanotextured slides) were evaluated as substrates for biomolecule microarrays. Their performance is compared with that of epoxy-coated glass slides. We found that the proposed three-dimensional (3D) slides offered significant improvements in terms of spot intensity, homogeneity, and reproducibility. In particular, they provided higher spot intensity, by a factor of at least 1.5, and significantly improved spot homogeneity when compared to the epoxy-silane coated ones (intra-spot and between spot coefficients of variation ranging between 5 and 15% for the 3D micro-nanotextured slides and between 25 and 85% for the epoxy-silane coated ones). The latter was to a great extent the result of a strong "coffee-ring" effect observed for the spots created on the epoxy-coated slides; a phenomenon that was severely reduced in the 3D micro-nanotextured slides. The 3D micro-nanotextured slides offered in addition higher signal to noise ratio values over a wide range of protein probe concentrations and shelf-life over one year without requirement for specific storage conditions. Finally, the protocols employed for protein probe immobilization were extremely simple. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. MHD-induced Energetic Ion Loss during H-mode Discharges in the National Spherical Torus Experiment (NSTX)

    Energy Technology Data Exchange (ETDEWEB)

    S.S. Medley; N.N. Gorelenkov; R. Andre; R.E. Bell; D.S. Darrow; E.D. Fredrickson; S.M. Kaye; B.P. LeBlanc; A.L. Roquemore; and the NSTX Team

    2004-03-15

    MHD-induced energetic ion loss in neutral-beam-heated H-mode [high-confinement mode] discharges in NSTX [National Spherical Torus Experiment] is discussed. A rich variety of energetic ion behavior resulting from magnetohydrodynamic (MHD) activity is observed in the NSTX using a horizontally scanning Neutral Particle Analyzer (NPA) whose sightline views across the three co-injected neutral beams. For example, onset of an n = 2 mode leads to relatively slow decay of the energetic ion population (E {approx} 10-100 keV) and consequently the neutron yield. The effect of reconnection events, sawteeth, and bounce fishbones differs from that observed for low-n, low-frequency, tearing-type MHD modes. In this case, prompt loss of the energetic ion population occurs on a time scale of less than or equal to 1 ms and a precipitous drop in the neutron yield occurs. This paper focuses on MHD-induced ion loss during H-mode operation in NSTX. After H-mode onset, the NPA charge-exchange spectrum usually exhibits a significant loss of energetic ions only for E > E(sub)b/2 where E(sub)b is the beam injection energy. The magnitude of the energetic ion loss was observed to decrease with increasing tangency radius, R(sub)tan, of the NPA sightline, increasing toroidal field, B(sub)T, and increasing neutral-beam injection energy, E(sub)b. TRANSP modeling suggests that MHD-induced ion loss is enhanced during H-mode operation due to an evolution of the q and beam deposition profiles that feeds both passing and trapped ions into the region of low-n MHD activity. ORBIT code analysis of particle interaction with a model magnetic perturbation supported the energy selectivity of the MHD-induced loss observed in the NPA measurements. Transport analysis with the TRANSP code using a fast-ion diffusion tool to emulate the observed MHD-induced energetic ion loss showed significant modifications of the neutral- beam heating as well as the power balance, thermal diffusivities, energy confinement times

  11. MHD-induced Energetic Ion Loss during H-mode Discharges in the National Spherical Torus Experiment (NSTX)

    International Nuclear Information System (INIS)

    Medley, S.S.; Gorelenkov, N.N.; Andre, R.; Bell, R.E.; Darrow, D.S.; Fredrickson, E.D.; Kaye, S.M.; LeBlanc, B.P.; Roquemore, A.L.

    2004-01-01

    MHD-induced energetic ion loss in neutral-beam-heated H-mode [high-confinement mode] discharges in NSTX [National Spherical Torus Experiment] is discussed. A rich variety of energetic ion behavior resulting from magnetohydrodynamic (MHD) activity is observed in the NSTX using a horizontally scanning Neutral Particle Analyzer (NPA) whose sightline views across the three co-injected neutral beams. For example, onset of an n = 2 mode leads to relatively slow decay of the energetic ion population (E ∼ 10-100 keV) and consequently the neutron yield. The effect of reconnection events, sawteeth, and bounce fishbones differs from that observed for low-n, low-frequency, tearing-type MHD modes. In this case, prompt loss of the energetic ion population occurs on a time scale of less than or equal to 1 ms and a precipitous drop in the neutron yield occurs. This paper focuses on MHD-induced ion loss during H-mode operation in NSTX. After H-mode onset, the NPA charge-exchange spectrum usually exhibits a significant loss of energetic ions only for E > E(sub)b/2 where E(sub)b is the beam injection energy. The magnitude of the energetic ion loss was observed to decrease with increasing tangency radius, R(sub)tan, of the NPA sightline, increasing toroidal field, B(sub)T, and increasing neutral-beam injection energy, E(sub)b. TRANSP modeling suggests that MHD-induced ion loss is enhanced during H-mode operation due to an evolution of the q and beam deposition profiles that feeds both passing and trapped ions into the region of low-n MHD activity. ORBIT code analysis of particle interaction with a model magnetic perturbation supported the energy selectivity of the MHD-induced loss observed in the NPA measurements. Transport analysis with the TRANSP code using a fast-ion diffusion tool to emulate the observed MHD-induced energetic ion loss showed significant modifications of the neutral- beam heating as well as the power balance, thermal diffusivities, energy confinement times, and

  12. High-performance liquid chromatographic method for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma.

    Science.gov (United States)

    Xie, Ying; Chen, Yi; Lin, Mei; Wen, Jun; Fan, Guorong; Wu, Yutian

    2007-05-09

    A high-performance liquid chromatographic method was developed and validated for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma. The coumarin components and the internal standard isopsoralen were extracted from plasma samples with the mixture of tert-butyl methyl ether and n-hexane (4:1, v/v). Chromatographic separation was performed on a C(18) column (200 mm x 4.6mm, 5 microm) with the mobile phase acetonitrile-methanol-water-acetic acid (20:15:65:2, v/v/v/v) at a flow-rate of 1.0 ml/min. Only the peak of oxypeucedanin hydrate and byak-angelicin could be detected in dog plasma after oral administration of ethanol extracts of A. dahurica mainly containing xanthotoxol, osthenol, imperatorin, oxypeucedanin hydrate and byak-angelicin. The calibration curves of oxypeucedanin hydrate and byak-angelicin were linear over a range of 22.08-8830.00 and 6.08-2430.00 ng/ml in dog plasma, respectively. The quantification limit of oxypeucedanin hydrate and byak-angelicin in dog plasma was 22.08 and 6.08 ng/ml, respectively. The intra- and inter-day precision was less than 7.6% and 8.5% and the accuracy was from 91.9% to 106.1%. The lowest absolute recoveries of oxypeucedanin hydrate and byak-angelicin were 85.7% and 87.0%, respectively. The method was successfully applied to the pharmacokinetic studies of oxypeucedanin hydrate and byak-angelicin in dog plasma after oral administration of ethanol extracts from A. dahurica.

  13. Effects of triangularity on confinement, density limit and profile stiffness of H-modes on ASDEX upgrade

    International Nuclear Information System (INIS)

    Stober, J.; Gruber, O.; Kallenbach, A.; Mertens, V.; Ryter, F.; Staebler, A.; Suttrop, W.; Treutterer, W.

    2000-01-01

    At ASDEX Upgrade the influence of triangularity on the H-mode performance has been studied intensively. It has been found that confinement increases with δ for a fixed line-averaged density. Though confinement decreases with increasing density for all analysed values of δ, H-factors (ITERH-98P) at the Greenwald density could be raised to 1 for the highest δ values achieved so far. The H-mode density limit could be increased by approx. 20%. There is a scatter of about 30% on the confinement data, which is anti-correlated to the average density in the scrape-off layer or the neutral fluxes outside the plasma. For nearly all discharges analysed so far, the temperature profiles are self-similar. This indication of profile stiffness could be verified by changing the heat-flux profile by changing the beam-voltage of the neutral-beam injection (NBI) at high density. At low density, first results indicate a deviation from this stiff behaviour. (author)

  14. Stabilizing effect of resistivity towards ELM-free H-mode discharge in lithium-conditioned NSTX

    Science.gov (United States)

    Banerjee, Debabrata; Zhu, Ping; Maingi, Rajesh

    2017-07-01

    Linear stability analysis of the national spherical torus experiment (NSTX) Li-conditioned ELM-free H-mode equilibria is carried out in the context of the extended magneto-hydrodynamic (MHD) model in NIMROD. The purpose is to investigate the physical cause behind edge localized mode (ELM) suppression in experiment after the Li-coating of the divertor and the first wall of the NSTX tokamak. Besides ideal MHD modeling, including finite-Larmor radius effect and two-fluid Hall and electron diamagnetic drift contributions, a non-ideal resistivity model is employed, taking into account the increase of Z eff after Li-conditioning in ELM-free H-mode. Unlike an earlier conclusion from an eigenvalue code analysis of these equilibria, NIMROD results find that after reduced recycling from divertor plates, profile modification is necessary but insufficient to explain the mechanism behind complete ELMs suppression in ideal two-fluid MHD. After considering the higher plasma resistivity due to higher Z eff, the complete stabilization could be explained. A thorough analysis of both pre-lithium ELMy and with-lithium ELM-free cases using ideal and non-ideal MHD models is presented, after accurately including a vacuum-like cold halo region in NIMROD to investigate ELMs.

  15. Development of anion-exchange/reversed-phase high performance liquid chromatography-inductively coupled plasma-mass spectrometry methods for the speciation of bio-available iodine and bromine from edible seaweed.

    Science.gov (United States)

    Romarís-Hortas, Vanessa; Bermejo-Barrera, Pilar; Moreda-Piñeiro, Antonio

    2012-05-04

    Anion exchange high performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry has been novelly applied to assess inorganic (iodide and iodate) and organic (3-iodotyrosine - MIT, and 3,5-diiodotyrosine - DIT) iodine species in a single chromatographic run. The optimized operating conditions (Dionex IonPac AS7, gradient elution with 175 mM ammonium nitrate plus 15% (v/v) methanol, pH 3.8, as a mobile phase and flow rates within the 0.5-1.5 mL min(-1) range) have also been used to perform inorganic bromine speciation analysis (bromide and bromate). The developed method has been applied for determining the bio-available contents of iodine and bromine species in dialyzates from edible seaweed. Reverse phase high performance liquid chromatography (Zorbax Eclipse XDB-C8, gradient elution with 0.2% (m/m) acetic acid, and 0.2% (m/m) acetic acid in methanol, as mobile phases, and a constant flow rate of 0.75 mL min(-1)) also hyphenated with inductively coupled plasma-mass spectrometry was used to confirm the presence of organic iodine species (MIT and DIT) in the dialyzates. The verification of the presence of iodinated amino acids (MIT and DIT) in the extracts was also performed by reverse phase high performance liquid chromatography-electrospray ionization-mass spectrometry (LTQ Orbitrap). The developed methods have provided good repeatability (RSD values lower than 10% for both anion exchange and reverse phase separations) and analytical recoveries within the 90-105% range for all cases. The in vitro bio-availability method consisted of a simulated gastric and an intestinal digestion/dialysis (10 kDa molecular weight cut-off - MWCO) two-stage procedure. Iodide and MIT were the main bio-available species quantified, whereas bromide was the major bromine species found in the extracts. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Clojure high performance programming

    CERN Document Server

    Kumar, Shantanu

    2013-01-01

    This is a short, practical guide that will teach you everything you need to know to start writing high performance Clojure code.This book is ideal for intermediate Clojure developers who are looking to get a good grip on how to achieve optimum performance. You should already have some experience with Clojure and it would help if you already know a little bit of Java. Knowledge of performance analysis and engineering is not required. For hands-on practice, you should have access to Clojure REPL with Leiningen.

  17. High performance data transfer

    Science.gov (United States)

    Cottrell, R.; Fang, C.; Hanushevsky, A.; Kreuger, W.; Yang, W.

    2017-10-01

    The exponentially increasing need for high speed data transfer is driven by big data, and cloud computing together with the needs of data intensive science, High Performance Computing (HPC), defense, the oil and gas industry etc. We report on the Zettar ZX software. This has been developed since 2013 to meet these growing needs by providing high performance data transfer and encryption in a scalable, balanced, easy to deploy and use way while minimizing power and space utilization. In collaboration with several commercial vendors, Proofs of Concept (PoC) consisting of clusters have been put together using off-the- shelf components to test the ZX scalability and ability to balance services using multiple cores, and links. The PoCs are based on SSD flash storage that is managed by a parallel file system. Each cluster occupies 4 rack units. Using the PoCs, between clusters we have achieved almost 200Gbps memory to memory over two 100Gbps links, and 70Gbps parallel file to parallel file with encryption over a 5000 mile 100Gbps link.

  18. Simultaneous determination of atorvastatin and valsartan in human plasma by solid-based disperser liquid-liquid microextraction followed by high-performance liquid chromatography-diode array detection.

    Science.gov (United States)

    Farajzadeh, Mir Ali; Khorram, Parisa; Pazhohan, Azar

    2016-04-01

    A simple, sensitive, and efficient method has been developed for simultaneous estimation of valsartan and atorvastatin in human plasma by combination of solid-based dispersive liquid-liquid microextraction and high performance liquid chromatography-diode array detection. In the proposed method, 1,2-dibromoethane (extraction solvent) is added on a sugar cube (as a solid disperser) and it is introduced into plasma sample containing the analytes. After manual shaking and centrifugation, the resultant sedimented phase is subjected to back extraction into a small volume of sodium hydrogen carbonate solution using air-assisted liquid-liquid microextraction. Then the cloudy solution is centrifuged and the obtained aqueous phase is transferred into a microtube and analyzed by the separation system. Under the optimal conditions, extraction recoveries are obtained in the range of 81-90%. Calibration curves plotted in drug-free plasma sample are linear in the ranges of 5-5000μgL(-1) for valsartan and 10-5000μgL(-1) for atorvastatin with the coefficients of determination higher than 0.997. Limits of detection and quantification of the studied analytes in plasma sample are 0.30-2.6 and 1.0-8.2μgL(-1), respectively. Intra-day (n=6) and inter-days (n=4) precisions of the method are satisfactory with relative standard deviations less than 7.4% (at three levels of 10, 500, and 2000μgL(-1), each analyte). These data suggest that the method can be successfully applied to determine trace amounts of valsartan and atorvastatin in human plasma samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Essential elements of the high density H-mode on W7-AS

    International Nuclear Information System (INIS)

    McCormick, K.; Burhenn, R.; Grigull, P.

    2003-01-01

    The High Density H-Mode (HDH), discovered during the run-in phase of W7-AS divertor operation/1-3/, rapidly became the workhorse of the divertor program, combining optimal core behavior along with edge parameters necessary for successful operation of an Island Divertor. Its unique properties of high energy confinement along with low impurity retention and radiation localized at the edge under ELM-free steady-state conditions at high densities (to 4 x 10 20 m -3 ) and heating powers (to 1.7 MWm -3 ) make the HDH H-mode ideal for a reactor scenario, given it can be extended to higher temperatures in a larger machine. Hence, considerable effort has been invested to understand the nature of the HDH-mode in order to be able to extrapolate to next generation devices. To this end the present paper reports on experiments where two globally-similar ELM-free H-modes are compared: the classic quiescent H-mode H* where both impurity and density control are a severe problem and the HDH-mode with its contrasting steady-state behavior. Through modeling of the temporal behavior of laser-ablated aluminum spectral lines, as well as that of background impurities, it is concluded that a principle difference between the two H-modes is that of enhanced impurity diffusion in the edge gradient region of the HDH-mode. However, no direct indicators of enhanced diffusion have yet been identified. (orig.)

  20. Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract

    Directory of Open Access Journals (Sweden)

    John Teye Azietaku

    2016-01-01

    Full Text Available A specific, sensitive, and reliable high performance liquid chromatography with fluorescence detection (HPLC-FLD was first optimized and then used in the simultaneous quantification of bergapten, imperatorin, notopterol, and isoimperatorin in rat plasma using osthole as the internal standard. Liquid-liquid extraction with ethyl acetate was employed in treating the rat plasma samples obtained. Separation was carried out with a Hedera™ ODS column (4.6 × 250 mm, 5 μm by gradient elution at a temperature of 40°C. Excitation and emission of the fluorescence detector were set to 300 and 490 nm, respectively. The lower limits of quantification for bergapten, imperatorin, notopterol, and isoimperatorin in rat plasma were 4, 40, 4, and 2 ng mL−1, respectively. The intraday and interday precision and accuracy for the four coumarins were within acceptable criteria. The recovery of the method was satisfactory with a range of 80.3–114%. The validated method was successfully used for the simultaneous determination of the four coumarins in Notopterygium incisum extracts and also for the pharmacokinetic and excretion study of bergapten, imperatorin, notopterol, and isoimperatorin in rats.

  1. Effect of nebulizer/spray chamber interfaces on simultaneous, axial view inductively coupled plasma optical emission spectrometry for the direct determination of As and Se species separated by ion exchange high-performance liquid chromatography

    International Nuclear Information System (INIS)

    Gettar, Raquel T.; Smichowski, Patricia; Garavaglia, Ricardo N.; Farias, Silvia; Batistoni, Daniel A.

    2005-01-01

    Different nebulizer/expansion chamber combinations were evaluated to assess their performance for sample introduction in the direct coupling with an axial view inductively coupled plasma multielement spectrometer for on-line determination of As and Se species previously separated by ion exchange-high performance liquid chromatography. The column effluents were injected into the plasma without prior derivatization. The instrument operation software was adapted for data acquisition and processing to allow multi-wavelength recording of the transient chromatographic peaks. After optimization of the chromatographic operating conditions, separation of mixtures of inorganic As and Se species, and of inorganic and two organic As species (monomethylarsonic and dimethylarsinic acids), was achieved with excellent resolution. Species discrimination from mixtures of As and Se oxyanions was further improved by the simultaneous element detection at specific analytical wavelengths. Three nebulizers and three spray chambers, employed in seven combinations, were tested as interfaces. Concentric nebulizers associated to a glass cyclonic chamber appear most suitable regarding sensitivity and signal to noise ratio. Measured element detection limits (3 σ) were around 10 ng ml -1 for all the species considered, making the method a viable alternative to similar procedures that employ volatile hydride generation previous to sample injection into the plasma. Analytical recoveries both for inorganic and organic species ranged between 92 and 107%. The method was demonstrated to be apt for the analysis of surface waters potentially subjected to natural contamination with arsenic

  2. High resolution main-ion charge exchange spectroscopy in the DIII-D H-mode pedestal.

    Science.gov (United States)

    Grierson, B A; Burrell, K H; Chrystal, C; Groebner, R J; Haskey, S R; Kaplan, D H

    2016-11-01

    A new high spatial resolution main-ion (deuterium) charge-exchange spectroscopy system covering the tokamak boundary region has been installed on the DIII-D tokamak. Sixteen new edge main-ion charge-exchange recombination sightlines have been combined with nineteen impurity sightlines in a tangentially viewing geometry on the DIII-D midplane with an interleaving design that achieves 8 mm inter-channel radial resolution for detailed profiles of main-ion temperature, velocity, charge-exchange emission, and neutral beam emission. At the plasma boundary, we find a strong enhancement of the main-ion toroidal velocity that exceeds the impurity velocity by a factor of two. The unique combination of experimentally measured main-ion and impurity profiles provides a powerful quasi-neutrality constraint for reconstruction of tokamak H-mode pedestals.

  3. Effect of progressively increasing lithium conditioning on edge transport and stability in high triangularity NSTX H-modes

    Energy Technology Data Exchange (ETDEWEB)

    Maingi, R., E-mail: rmaingi@pppl.gov [Princeton Plasma Physics Laboratory, 100 Stellarator Road, Princeton, NJ 08543 (United States); Canik, J.M. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Bell, R.E. [Princeton Plasma Physics Laboratory, 100 Stellarator Road, Princeton, NJ 08543 (United States); Boyle, D.P. [Princeton University, Princeton, NJ (United States); Diallo, A.; Kaita, R.; Kaye, S.M.; LeBlanc, B.P. [Princeton Plasma Physics Laboratory, 100 Stellarator Road, Princeton, NJ 08543 (United States); Sabbagh, S.A. [Columbia University, New York, NY (United States); Scotti, F.; Soukhanovskii, V.A. [Lawrence Livermore National Laboratory, Livermore, CA (United States)

    2017-04-15

    A sequence of H-mode discharges with increasing levels of pre-discharge lithium evaporation (‘dose’) was conducted in high triangularity and elongation boundary shape in NSTX. Energy confinement increased, and recycling decreased with increasing lithium dose, similar to a previous lithium dose scan in medium triangularity and elongation plasmas. Data-constrained SOLPS interpretive modeling quantified the edge transport change: the electron particle diffusivity decreased by 10–30x. The electron thermal diffusivity decreased by 4x just inside the top of the pedestal, but increased by up to 5x very near the separatrix. These results provide a baseline expectation for lithium benefits in NSTX-U, which is optimized for a boundary shape similar to the one in this experiment.

  4. Critical edge parameters for H-mode transition in DIII-D

    International Nuclear Information System (INIS)

    Groebner, R.J.; Carlstrom, T.N.

    1997-11-01

    Measurements in DIII-D of edge ion and electron temperatures (T i and T e ) just prior to the transition to H-mode are presented. A fitting model based on a hyperbolic tangent function is used in the analysis. The edge temperatures are observed to increase during the L-phase with the application of auxiliary heating. The temperature rise is small if the H-mode power threshold is close to the Ohmic power level in the absence of auxiliary heating and is large if the H-mode threshold is well above the Ohmic power level. The edge temperatures just prior to the transition are approximately proportional to the toroidal magnetic field Bt for the field either in the reversed or forward direction. However, for the reversed magnetic field, the temperatures are at least a factor of two higher than for the forward