WorldWideScience

Sample records for high-dimensional input space

  1. Reduced basis ANOVA methods for partial differential equations with high-dimensional random inputs

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Qifeng, E-mail: liaoqf@shanghaitech.edu.cn [School of Information Science and Technology, ShanghaiTech University, Shanghai 200031 (China); Lin, Guang, E-mail: guanglin@purdue.edu [Department of Mathematics & School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907 (United States)

    2016-07-15

    In this paper we present a reduced basis ANOVA approach for partial deferential equations (PDEs) with random inputs. The ANOVA method combined with stochastic collocation methods provides model reduction in high-dimensional parameter space through decomposing high-dimensional inputs into unions of low-dimensional inputs. In this work, to further reduce the computational cost, we investigate spatial low-rank structures in the ANOVA-collocation method, and develop efficient spatial model reduction techniques using hierarchically generated reduced bases. We present a general mathematical framework of the methodology, validate its accuracy and demonstrate its efficiency with numerical experiments.

  2. Reinforcement learning on slow features of high-dimensional input streams.

    Directory of Open Access Journals (Sweden)

    Robert Legenstein

    Full Text Available Humans and animals are able to learn complex behaviors based on a massive stream of sensory information from different modalities. Early animal studies have identified learning mechanisms that are based on reward and punishment such that animals tend to avoid actions that lead to punishment whereas rewarded actions are reinforced. However, most algorithms for reward-based learning are only applicable if the dimensionality of the state-space is sufficiently small or its structure is sufficiently simple. Therefore, the question arises how the problem of learning on high-dimensional data is solved in the brain. In this article, we propose a biologically plausible generic two-stage learning system that can directly be applied to raw high-dimensional input streams. The system is composed of a hierarchical slow feature analysis (SFA network for preprocessing and a simple neural network on top that is trained based on rewards. We demonstrate by computer simulations that this generic architecture is able to learn quite demanding reinforcement learning tasks on high-dimensional visual input streams in a time that is comparable to the time needed when an explicit highly informative low-dimensional state-space representation is given instead of the high-dimensional visual input. The learning speed of the proposed architecture in a task similar to the Morris water maze task is comparable to that found in experimental studies with rats. This study thus supports the hypothesis that slowness learning is one important unsupervised learning principle utilized in the brain to form efficient state representations for behavioral learning.

  3. Manifold learning to interpret JET high-dimensional operational space

    International Nuclear Information System (INIS)

    Cannas, B; Fanni, A; Pau, A; Sias, G; Murari, A

    2013-01-01

    In this paper, the problem of visualization and exploration of JET high-dimensional operational space is considered. The data come from plasma discharges selected from JET campaigns from C15 (year 2005) up to C27 (year 2009). The aim is to learn the possible manifold structure embedded in the data and to create some representations of the plasma parameters on low-dimensional maps, which are understandable and which preserve the essential properties owned by the original data. A crucial issue for the design of such mappings is the quality of the dataset. This paper reports the details of the criteria used to properly select suitable signals downloaded from JET databases in order to obtain a dataset of reliable observations. Moreover, a statistical analysis is performed to recognize the presence of outliers. Finally data reduction, based on clustering methods, is performed to select a limited and representative number of samples for the operational space mapping. The high-dimensional operational space of JET is mapped using a widely used manifold learning method, the self-organizing maps. The results are compared with other data visualization methods. The obtained maps can be used to identify characteristic regions of the plasma scenario, allowing to discriminate between regions with high risk of disruption and those with low risk of disruption. (paper)

  4. The literary uses of high-dimensional space

    Directory of Open Access Journals (Sweden)

    Ted Underwood

    2015-12-01

    Full Text Available Debates over “Big Data” shed more heat than light in the humanities, because the term ascribes new importance to statistical methods without explaining how those methods have changed. What we badly need instead is a conversation about the substantive innovations that have made statistical modeling useful for disciplines where, in the past, it truly wasn’t. These innovations are partly technical, but more fundamentally expressed in what Leo Breiman calls a new “culture” of statistical modeling. Where 20th-century methods often required humanists to squeeze our unstructured texts, sounds, or images into some special-purpose data model, new methods can handle unstructured evidence more directly by modeling it in a high-dimensional space. This opens a range of research opportunities that humanists have barely begun to discuss. To date, topic modeling has received most attention, but in the long run, supervised predictive models may be even more important. I sketch their potential by describing how Jordan Sellers and I have begun to model poetic distinction in the long 19th century—revealing an arc of gradual change much longer than received literary histories would lead us to expect.

  5. Data analysis in high-dimensional sparse spaces

    DEFF Research Database (Denmark)

    Clemmensen, Line Katrine Harder

    classification techniques for high-dimensional problems are presented: Sparse discriminant analysis, sparse mixture discriminant analysis and orthogonality constrained support vector machines. The first two introduces sparseness to the well known linear and mixture discriminant analysis and thereby provide low...... are applied to classifications of fish species, ear canal impressions used in the hearing aid industry, microbiological fungi species, and various cancerous tissues and healthy tissues. In addition, novel applications of sparse regressions (also called the elastic net) to the medical, concrete, and food...

  6. Efficient and accurate nearest neighbor and closest pair search in high-dimensional space

    KAUST Repository

    Tao, Yufei; Yi, Ke; Sheng, Cheng; Kalnis, Panos

    2010-01-01

    Nearest Neighbor (NN) search in high-dimensional space is an important problem in many applications. From the database perspective, a good solution needs to have two properties: (i) it can be easily incorporated in a relational database, and (ii

  7. On High Dimensional Searching Spaces and Learning Methods

    DEFF Research Database (Denmark)

    Yazdani, Hossein; Ortiz-Arroyo, Daniel; Choros, Kazimierz

    2017-01-01

    , and similarity functions and discuss the pros and cons of using each of them. Conventional similarity functions evaluate objects in the vector space. Contrarily, Weighted Feature Distance (WFD) functions compare data objects in both feature and vector spaces, preventing the system from being affected by some...

  8. Aspects of high-dimensional theories in embedding spaces

    International Nuclear Information System (INIS)

    Maia, M.D.; Mecklenburg, W.

    1983-01-01

    The question of whether physical meaning may be attributed to the extra dimensions provided by embedding procedures as applied to physical space-times is discussed. The similarities and differences of the present picture to that of conventional Kaluza-Klein pictures are commented. (Author) [pt

  9. Distribution of high-dimensional entanglement via an intra-city free-space link.

    Science.gov (United States)

    Steinlechner, Fabian; Ecker, Sebastian; Fink, Matthias; Liu, Bo; Bavaresco, Jessica; Huber, Marcus; Scheidl, Thomas; Ursin, Rupert

    2017-07-24

    Quantum entanglement is a fundamental resource in quantum information processing and its distribution between distant parties is a key challenge in quantum communications. Increasing the dimensionality of entanglement has been shown to improve robustness and channel capacities in secure quantum communications. Here we report on the distribution of genuine high-dimensional entanglement via a 1.2-km-long free-space link across Vienna. We exploit hyperentanglement, that is, simultaneous entanglement in polarization and energy-time bases, to encode quantum information, and observe high-visibility interference for successive correlation measurements in each degree of freedom. These visibilities impose lower bounds on entanglement in each subspace individually and certify four-dimensional entanglement for the hyperentangled system. The high-fidelity transmission of high-dimensional entanglement under real-world atmospheric link conditions represents an important step towards long-distance quantum communications with more complex quantum systems and the implementation of advanced quantum experiments with satellite links.

  10. Efficient and accurate nearest neighbor and closest pair search in high-dimensional space

    KAUST Repository

    Tao, Yufei

    2010-07-01

    Nearest Neighbor (NN) search in high-dimensional space is an important problem in many applications. From the database perspective, a good solution needs to have two properties: (i) it can be easily incorporated in a relational database, and (ii) its query cost should increase sublinearly with the dataset size, regardless of the data and query distributions. Locality-Sensitive Hashing (LSH) is a well-known methodology fulfilling both requirements, but its current implementations either incur expensive space and query cost, or abandon its theoretical guarantee on the quality of query results. Motivated by this, we improve LSH by proposing an access method called the Locality-Sensitive B-tree (LSB-tree) to enable fast, accurate, high-dimensional NN search in relational databases. The combination of several LSB-trees forms a LSB-forest that has strong quality guarantees, but improves dramatically the efficiency of the previous LSH implementation having the same guarantees. In practice, the LSB-tree itself is also an effective index which consumes linear space, supports efficient updates, and provides accurate query results. In our experiments, the LSB-tree was faster than: (i) iDistance (a famous technique for exact NN search) by two orders ofmagnitude, and (ii) MedRank (a recent approximate method with nontrivial quality guarantees) by one order of magnitude, and meanwhile returned much better results. As a second step, we extend our LSB technique to solve another classic problem, called Closest Pair (CP) search, in high-dimensional space. The long-term challenge for this problem has been to achieve subquadratic running time at very high dimensionalities, which fails most of the existing solutions. We show that, using a LSB-forest, CP search can be accomplished in (worst-case) time significantly lower than the quadratic complexity, yet still ensuring very good quality. In practice, accurate answers can be found using just two LSB-trees, thus giving a substantial

  11. High-dimensional free-space optical communications based on orbital angular momentum coding

    Science.gov (United States)

    Zou, Li; Gu, Xiaofan; Wang, Le

    2018-03-01

    In this paper, we propose a high-dimensional free-space optical communication scheme using orbital angular momentum (OAM) coding. In the scheme, the transmitter encodes N-bits information by using a spatial light modulator to convert a Gaussian beam to a superposition mode of N OAM modes and a Gaussian mode; The receiver decodes the information through an OAM mode analyser which consists of a MZ interferometer with a rotating Dove prism, a photoelectric detector and a computer carrying out the fast Fourier transform. The scheme could realize a high-dimensional free-space optical communication, and decodes the information much fast and accurately. We have verified the feasibility of the scheme by exploiting 8 (4) OAM modes and a Gaussian mode to implement a 256-ary (16-ary) coding free-space optical communication to transmit a 256-gray-scale (16-gray-scale) picture. The results show that a zero bit error rate performance has been achieved.

  12. Compound Structure-Independent Activity Prediction in High-Dimensional Target Space.

    Science.gov (United States)

    Balfer, Jenny; Hu, Ye; Bajorath, Jürgen

    2014-08-01

    Profiling of compound libraries against arrays of targets has become an important approach in pharmaceutical research. The prediction of multi-target compound activities also represents an attractive task for machine learning with potential for drug discovery applications. Herein, we have explored activity prediction in high-dimensional target space. Different types of models were derived to predict multi-target activities. The models included naïve Bayesian (NB) and support vector machine (SVM) classifiers based upon compound structure information and NB models derived on the basis of activity profiles, without considering compound structure. Because the latter approach can be applied to incomplete training data and principally depends on the feature independence assumption, SVM modeling was not applicable in this case. Furthermore, iterative hybrid NB models making use of both activity profiles and compound structure information were built. In high-dimensional target space, NB models utilizing activity profile data were found to yield more accurate activity predictions than structure-based NB and SVM models or hybrid models. An in-depth analysis of activity profile-based models revealed the presence of correlation effects across different targets and rationalized prediction accuracy. Taken together, the results indicate that activity profile information can be effectively used to predict the activity of test compounds against novel targets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. A New Ensemble Method with Feature Space Partitioning for High-Dimensional Data Classification

    Directory of Open Access Journals (Sweden)

    Yongjun Piao

    2015-01-01

    Full Text Available Ensemble data mining methods, also known as classifier combination, are often used to improve the performance of classification. Various classifier combination methods such as bagging, boosting, and random forest have been devised and have received considerable attention in the past. However, data dimensionality increases rapidly day by day. Such a trend poses various challenges as these methods are not suitable to directly apply to high-dimensional datasets. In this paper, we propose an ensemble method for classification of high-dimensional data, with each classifier constructed from a different set of features determined by partitioning of redundant features. In our method, the redundancy of features is considered to divide the original feature space. Then, each generated feature subset is trained by a support vector machine, and the results of each classifier are combined by majority voting. The efficiency and effectiveness of our method are demonstrated through comparisons with other ensemble techniques, and the results show that our method outperforms other methods.

  14. Individual-based models for adaptive diversification in high-dimensional phenotype spaces.

    Science.gov (United States)

    Ispolatov, Iaroslav; Madhok, Vaibhav; Doebeli, Michael

    2016-02-07

    Most theories of evolutionary diversification are based on equilibrium assumptions: they are either based on optimality arguments involving static fitness landscapes, or they assume that populations first evolve to an equilibrium state before diversification occurs, as exemplified by the concept of evolutionary branching points in adaptive dynamics theory. Recent results indicate that adaptive dynamics may often not converge to equilibrium points and instead generate complicated trajectories if evolution takes place in high-dimensional phenotype spaces. Even though some analytical results on diversification in complex phenotype spaces are available, to study this problem in general we need to reconstruct individual-based models from the adaptive dynamics generating the non-equilibrium dynamics. Here we first provide a method to construct individual-based models such that they faithfully reproduce the given adaptive dynamics attractor without diversification. We then show that a propensity to diversify can be introduced by adding Gaussian competition terms that generate frequency dependence while still preserving the same adaptive dynamics. For sufficiently strong competition, the disruptive selection generated by frequency-dependence overcomes the directional evolution along the selection gradient and leads to diversification in phenotypic directions that are orthogonal to the selection gradient. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. TripAdvisor^{N-D}: A Tourism-Inspired High-Dimensional Space Exploration Framework with Overview and Detail.

    Science.gov (United States)

    Nam, Julia EunJu; Mueller, Klaus

    2013-02-01

    Gaining a true appreciation of high-dimensional space remains difficult since all of the existing high-dimensional space exploration techniques serialize the space travel in some way. This is not so foreign to us since we, when traveling, also experience the world in a serial fashion. But we typically have access to a map to help with positioning, orientation, navigation, and trip planning. Here, we propose a multivariate data exploration tool that compares high-dimensional space navigation with a sightseeing trip. It decomposes this activity into five major tasks: 1) Identify the sights: use a map to identify the sights of interest and their location; 2) Plan the trip: connect the sights of interest along a specifyable path; 3) Go on the trip: travel along the route; 4) Hop off the bus: experience the location, look around, zoom into detail; and 5) Orient and localize: regain bearings in the map. We describe intuitive and interactive tools for all of these tasks, both global navigation within the map and local exploration of the data distributions. For the latter, we describe a polygonal touchpad interface which enables users to smoothly tilt the projection plane in high-dimensional space to produce multivariate scatterplots that best convey the data relationships under investigation. Motion parallax and illustrative motion trails aid in the perception of these transient patterns. We describe the use of our system within two applications: 1) the exploratory discovery of data configurations that best fit a personal preference in the presence of tradeoffs and 2) interactive cluster analysis via cluster sculpting in N-D.

  16. Representations of space based on haptic input

    NARCIS (Netherlands)

    Zuidhoek, S.

    2005-01-01

    The present thesis focused on the representations of grasping space based on haptic input. We aimed at identifying their characteristics, and the underlying neurocognitive processes and mechanisms. To this end, we studied the systematic distortions in performance on several orientation perception

  17. AN EFFECTIVE MULTI-CLUSTERING ANONYMIZATION APPROACH USING DISCRETE COMPONENT TASK FOR NON-BINARY HIGH DIMENSIONAL DATA SPACES

    Directory of Open Access Journals (Sweden)

    L.V. Arun Shalin

    2016-01-01

    Full Text Available Clustering is a process of grouping elements together, designed in such a way that the elements assigned to similar data points in a cluster are more comparable to each other than the remaining data points in a cluster. During clustering certain difficulties related when dealing with high dimensional data are ubiquitous and abundant. Works concentrated using anonymization method for high dimensional data spaces failed to address the problem related to dimensionality reduction during the inclusion of non-binary databases. In this work we study methods for dimensionality reduction for non-binary database. By analyzing the behavior of dimensionality reduction for non-binary database, results in performance improvement with the help of tag based feature. An effective multi-clustering anonymization approach called Discrete Component Task Specific Multi-Clustering (DCTSM is presented for dimensionality reduction on non-binary database. To start with we present the analysis of attribute in the non-binary database and cluster projection identifies the sparseness degree of dimensions. Additionally with the quantum distribution on multi-cluster dimension, the solution for relevancy of attribute and redundancy on non-binary data spaces is provided resulting in performance improvement on the basis of tag based feature. Multi-clustering tag based feature reduction extracts individual features and are correspondingly replaced by the equivalent feature clusters (i.e. tag clusters. During training, the DCTSM approach uses multi-clusters instead of individual tag features and then during decoding individual features is replaced by corresponding multi-clusters. To measure the effectiveness of the method, experiments are conducted on existing anonymization method for high dimensional data spaces and compared with the DCTSM approach using Statlog German Credit Data Set. Improved tag feature extraction and minimum error rate compared to conventional anonymization

  18. Extending the Generalised Pareto Distribution for Novelty Detection in High-Dimensional Spaces.

    Science.gov (United States)

    Clifton, David A; Clifton, Lei; Hugueny, Samuel; Tarassenko, Lionel

    2014-01-01

    Novelty detection involves the construction of a "model of normality", and then classifies test data as being either "normal" or "abnormal" with respect to that model. For this reason, it is often termed one-class classification. The approach is suitable for cases in which examples of "normal" behaviour are commonly available, but in which cases of "abnormal" data are comparatively rare. When performing novelty detection, we are typically most interested in the tails of the normal model, because it is in these tails that a decision boundary between "normal" and "abnormal" areas of data space usually lies. Extreme value statistics provides an appropriate theoretical framework for modelling the tails of univariate (or low-dimensional) distributions, using the generalised Pareto distribution (GPD), which can be demonstrated to be the limiting distribution for data occurring within the tails of most practically-encountered probability distributions. This paper provides an extension of the GPD, allowing the modelling of probability distributions of arbitrarily high dimension, such as occurs when using complex, multimodel, multivariate distributions for performing novelty detection in most real-life cases. We demonstrate our extension to the GPD using examples from patient physiological monitoring, in which we have acquired data from hospital patients in large clinical studies of high-acuity wards, and in which we wish to determine "abnormal" patient data, such that early warning of patient physiological deterioration may be provided.

  19. High-dimensional structured light coding/decoding for free-space optical communications free of obstructions.

    Science.gov (United States)

    Du, Jing; Wang, Jian

    2015-11-01

    Bessel beams carrying orbital angular momentum (OAM) with helical phase fronts exp(ilφ)(l=0;±1;±2;…), where φ is the azimuthal angle and l corresponds to the topological number, are orthogonal with each other. This feature of Bessel beams provides a new dimension to code/decode data information on the OAM state of light, and the theoretical infinity of topological number enables possible high-dimensional structured light coding/decoding for free-space optical communications. Moreover, Bessel beams are nondiffracting beams having the ability to recover by themselves in the face of obstructions, which is important for free-space optical communications relying on line-of-sight operation. By utilizing the OAM and nondiffracting characteristics of Bessel beams, we experimentally demonstrate 12 m distance obstruction-free optical m-ary coding/decoding using visible Bessel beams in a free-space optical communication system. We also study the bit error rate (BER) performance of hexadecimal and 32-ary coding/decoding based on Bessel beams with different topological numbers. After receiving 500 symbols at the receiver side, a zero BER of hexadecimal coding/decoding is observed when the obstruction is placed along the propagation path of light.

  20. Mining High-Dimensional Data

    Science.gov (United States)

    Wang, Wei; Yang, Jiong

    With the rapid growth of computational biology and e-commerce applications, high-dimensional data becomes very common. Thus, mining high-dimensional data is an urgent problem of great practical importance. However, there are some unique challenges for mining data of high dimensions, including (1) the curse of dimensionality and more crucial (2) the meaningfulness of the similarity measure in the high dimension space. In this chapter, we present several state-of-art techniques for analyzing high-dimensional data, e.g., frequent pattern mining, clustering, and classification. We will discuss how these methods deal with the challenges of high dimensionality.

  1. Lip-reading aids word recognition most in moderate noise: a Bayesian explanation using high-dimensional feature space.

    Science.gov (United States)

    Ma, Wei Ji; Zhou, Xiang; Ross, Lars A; Foxe, John J; Parra, Lucas C

    2009-01-01

    Watching a speaker's facial movements can dramatically enhance our ability to comprehend words, especially in noisy environments. From a general doctrine of combining information from different sensory modalities (the principle of inverse effectiveness), one would expect that the visual signals would be most effective at the highest levels of auditory noise. In contrast, we find, in accord with a recent paper, that visual information improves performance more at intermediate levels of auditory noise than at the highest levels, and we show that a novel visual stimulus containing only temporal information does the same. We present a Bayesian model of optimal cue integration that can explain these conflicts. In this model, words are regarded as points in a multidimensional space and word recognition is a probabilistic inference process. When the dimensionality of the feature space is low, the Bayesian model predicts inverse effectiveness; when the dimensionality is high, the enhancement is maximal at intermediate auditory noise levels. When the auditory and visual stimuli differ slightly in high noise, the model makes a counterintuitive prediction: as sound quality increases, the proportion of reported words corresponding to the visual stimulus should first increase and then decrease. We confirm this prediction in a behavioral experiment. We conclude that auditory-visual speech perception obeys the same notion of optimality previously observed only for simple multisensory stimuli.

  2. Lip-reading aids word recognition most in moderate noise: a Bayesian explanation using high-dimensional feature space.

    Directory of Open Access Journals (Sweden)

    Wei Ji Ma

    Full Text Available Watching a speaker's facial movements can dramatically enhance our ability to comprehend words, especially in noisy environments. From a general doctrine of combining information from different sensory modalities (the principle of inverse effectiveness, one would expect that the visual signals would be most effective at the highest levels of auditory noise. In contrast, we find, in accord with a recent paper, that visual information improves performance more at intermediate levels of auditory noise than at the highest levels, and we show that a novel visual stimulus containing only temporal information does the same. We present a Bayesian model of optimal cue integration that can explain these conflicts. In this model, words are regarded as points in a multidimensional space and word recognition is a probabilistic inference process. When the dimensionality of the feature space is low, the Bayesian model predicts inverse effectiveness; when the dimensionality is high, the enhancement is maximal at intermediate auditory noise levels. When the auditory and visual stimuli differ slightly in high noise, the model makes a counterintuitive prediction: as sound quality increases, the proportion of reported words corresponding to the visual stimulus should first increase and then decrease. We confirm this prediction in a behavioral experiment. We conclude that auditory-visual speech perception obeys the same notion of optimality previously observed only for simple multisensory stimuli.

  3. Clustering high dimensional data

    DEFF Research Database (Denmark)

    Assent, Ira

    2012-01-01

    High-dimensional data, i.e., data described by a large number of attributes, pose specific challenges to clustering. The so-called ‘curse of dimensionality’, coined originally to describe the general increase in complexity of various computational problems as dimensionality increases, is known...... to render traditional clustering algorithms ineffective. The curse of dimensionality, among other effects, means that with increasing number of dimensions, a loss of meaningful differentiation between similar and dissimilar objects is observed. As high-dimensional objects appear almost alike, new approaches...... for clustering are required. Consequently, recent research has focused on developing techniques and clustering algorithms specifically for high-dimensional data. Still, open research issues remain. Clustering is a data mining task devoted to the automatic grouping of data based on mutual similarity. Each cluster...

  4. High dimensional entanglement

    CSIR Research Space (South Africa)

    Mc

    2012-07-01

    Full Text Available stream_source_info McLaren_2012.pdf.txt stream_content_type text/plain stream_size 2190 Content-Encoding ISO-8859-1 stream_name McLaren_2012.pdf.txt Content-Type text/plain; charset=ISO-8859-1 High dimensional... entanglement M. McLAREN1,2, F.S. ROUX1 & A. FORBES1,2,3 1. CSIR National Laser Centre, PO Box 395, Pretoria 0001 2. School of Physics, University of the Stellenbosch, Private Bag X1, 7602, Matieland 3. School of Physics, University of Kwazulu...

  5. Muscle synergies in neuroscience and robotics: from input-space to task-space perspectives

    Directory of Open Access Journals (Sweden)

    Cristiano eAlessandro

    2013-04-01

    Full Text Available In this paper we review the works related to muscle synergies that have been carried-out in neuroscience and control engineering. In particular, we refer to the hypothesis that the central nervous system (CNS generates desired muscle contractions by combining a small number of predefined modules, called muscle synergies. We provide an overview of the methods that have been employed to test the validity of this scheme, and we show how the concept of muscle synergy has been generalized for the control of artificial agents. The comparison between these two lines of research, in particular their different goals and approaches, is instrumental to explain the computational implications of the hypothesized modular organization. Moreover, it clarifies the importance of assessing the functional role of muscle synergies: although these basic modules are defined at the level of muscle activations (input-space, they should result in the effective accomplishment of the desired task. This requirement is not always explicitly considered in experimental neuroscience, as muscle synergies are often estimated solely by analyzing recorded muscle activities. We suggest that synergy extraction methods should explicitly take into account task execution variables, thus moving from a perspective purely based on input-space to one grounded on task-space as well.

  6. hdm: High-dimensional metrics

    OpenAIRE

    Chernozhukov, Victor; Hansen, Christian; Spindler, Martin

    2016-01-01

    In this article the package High-dimensional Metrics (\\texttt{hdm}) is introduced. It is a collection of statistical methods for estimation and quantification of uncertainty in high-dimensional approximately sparse models. It focuses on providing confidence intervals and significance testing for (possibly many) low-dimensional subcomponents of the high-dimensional parameter vector. Efficient estimators and uniformly valid confidence intervals for regression coefficients on target variables (e...

  7. Space Vector Modulation for an Indirect Matrix Converter with Improved Input Power Factor

    Directory of Open Access Journals (Sweden)

    Nguyen Dinh Tuyen

    2017-04-01

    Full Text Available Pulse width modulation strategies have been developed for indirect matrix converters (IMCs in order to improve their performance. In indirect matrix converters, the LC input filter is used to remove input current harmonics and electromagnetic interference problems. Unfortunately, due to the existence of the input filter, the input power factor is diminished, especially during operation at low voltage outputs. In this paper, a new space vector modulation (SVM is proposed to compensate for the input power factor of the indirect matrix converter. Both computer simulation and experimental studies through hardware implementation were performed to verify the effectiveness of the proposed modulation strategy.

  8. Variance inflation in high dimensional Support Vector Machines

    DEFF Research Database (Denmark)

    Abrahamsen, Trine Julie; Hansen, Lars Kai

    2013-01-01

    Many important machine learning models, supervised and unsupervised, are based on simple Euclidean distance or orthogonal projection in a high dimensional feature space. When estimating such models from small training sets we face the problem that the span of the training data set input vectors...... the case of Support Vector Machines (SVMS) and we propose a non-parametric scheme to restore proper generalizability. We illustrate the algorithm and its ability to restore performance on a wide range of benchmark data sets....... follow a different probability law with less variance. While the problem and basic means to reconstruct and deflate are well understood in unsupervised learning, the case of supervised learning is less well understood. We here investigate the effect of variance inflation in supervised learning including...

  9. High-dimensional covariance estimation with high-dimensional data

    CERN Document Server

    Pourahmadi, Mohsen

    2013-01-01

    Methods for estimating sparse and large covariance matrices Covariance and correlation matrices play fundamental roles in every aspect of the analysis of multivariate data collected from a variety of fields including business and economics, health care, engineering, and environmental and physical sciences. High-Dimensional Covariance Estimation provides accessible and comprehensive coverage of the classical and modern approaches for estimating covariance matrices as well as their applications to the rapidly developing areas lying at the intersection of statistics and mac

  10. Summary of astronaut inputs on automation and robotics for Space Station Freedom

    Science.gov (United States)

    Weeks, David J.

    1990-01-01

    Astronauts and payload specialists present specific recommendations in the form of an overview that relate to the use of automation and robotics on the Space Station Freedom. The inputs are based on on-orbit operations experience, time requirements for crews, and similar crew-specific knowledge that address the impacts of automation and robotics on productivity. Interview techniques and specific questionnaire results are listed, and the majority of the responses indicate that incorporating automation and robotics to some extent and with human backup can improve productivity. Specific support is found for the use of advanced automation and EVA robotics on the Space Station Freedom and for the use of advanced automation on ground-based stations. Ground-based control of in-flight robotics is required, and Space Station activities and crew tasks should be analyzed to assess the systems engineering approach for incorporating automation and robotics.

  11. Modeling high dimensional multichannel brain signals

    KAUST Repository

    Hu, Lechuan

    2017-03-27

    In this paper, our goal is to model functional and effective (directional) connectivity in network of multichannel brain physiological signals (e.g., electroencephalograms, local field potentials). The primary challenges here are twofold: first, there are major statistical and computational difficulties for modeling and analyzing high dimensional multichannel brain signals; second, there is no set of universally-agreed measures for characterizing connectivity. To model multichannel brain signals, our approach is to fit a vector autoregressive (VAR) model with sufficiently high order so that complex lead-lag temporal dynamics between the channels can be accurately characterized. However, such a model contains a large number of parameters. Thus, we will estimate the high dimensional VAR parameter space by our proposed hybrid LASSLE method (LASSO+LSE) which is imposes regularization on the first step (to control for sparsity) and constrained least squares estimation on the second step (to improve bias and mean-squared error of the estimator). Then to characterize connectivity between channels in a brain network, we will use various measures but put an emphasis on partial directed coherence (PDC) in order to capture directional connectivity between channels. PDC is a directed frequency-specific measure that explains the extent to which the present oscillatory activity in a sender channel influences the future oscillatory activity in a specific receiver channel relative all possible receivers in the network. Using the proposed modeling approach, we have achieved some insights on learning in a rat engaged in a non-spatial memory task.

  12. Modeling high dimensional multichannel brain signals

    KAUST Repository

    Hu, Lechuan; Fortin, Norbert; Ombao, Hernando

    2017-01-01

    In this paper, our goal is to model functional and effective (directional) connectivity in network of multichannel brain physiological signals (e.g., electroencephalograms, local field potentials). The primary challenges here are twofold: first, there are major statistical and computational difficulties for modeling and analyzing high dimensional multichannel brain signals; second, there is no set of universally-agreed measures for characterizing connectivity. To model multichannel brain signals, our approach is to fit a vector autoregressive (VAR) model with sufficiently high order so that complex lead-lag temporal dynamics between the channels can be accurately characterized. However, such a model contains a large number of parameters. Thus, we will estimate the high dimensional VAR parameter space by our proposed hybrid LASSLE method (LASSO+LSE) which is imposes regularization on the first step (to control for sparsity) and constrained least squares estimation on the second step (to improve bias and mean-squared error of the estimator). Then to characterize connectivity between channels in a brain network, we will use various measures but put an emphasis on partial directed coherence (PDC) in order to capture directional connectivity between channels. PDC is a directed frequency-specific measure that explains the extent to which the present oscillatory activity in a sender channel influences the future oscillatory activity in a specific receiver channel relative all possible receivers in the network. Using the proposed modeling approach, we have achieved some insights on learning in a rat engaged in a non-spatial memory task.

  13. High-Dimensional Metrics in R

    OpenAIRE

    Chernozhukov, Victor; Hansen, Chris; Spindler, Martin

    2016-01-01

    The package High-dimensional Metrics (\\Rpackage{hdm}) is an evolving collection of statistical methods for estimation and quantification of uncertainty in high-dimensional approximately sparse models. It focuses on providing confidence intervals and significance testing for (possibly many) low-dimensional subcomponents of the high-dimensional parameter vector. Efficient estimators and uniformly valid confidence intervals for regression coefficients on target variables (e.g., treatment or poli...

  14. State Estimation of International Space Station Centrifuge Rotor With Incomplete Knowledge of Disturbance Inputs

    Science.gov (United States)

    Sullivan, Michael J.

    2005-01-01

    This thesis develops a state estimation algorithm for the Centrifuge Rotor (CR) system where only relative measurements are available with limited knowledge of both rotor imbalance disturbances and International Space Station (ISS) thruster disturbances. A Kalman filter is applied to a plant model augmented with sinusoidal disturbance states used to model both the effect of the rotor imbalance and the 155 thrusters on the CR relative motion measurement. The sinusoidal disturbance states compensate for the lack of the availability of plant inputs for use in the Kalman filter. Testing confirms that complete disturbance modeling is necessary to ensure reliable estimation. Further testing goes on to show that increased estimator operational bandwidth can be achieved through the expansion of the disturbance model within the filter dynamics. In addition, Monte Carlo analysis shows the varying levels of robustness against defined plant/filter uncertainty variations.

  15. Unconscious integration of multisensory bodily inputs in the peripersonal space shapes bodily self-consciousness.

    Science.gov (United States)

    Salomon, Roy; Noel, Jean-Paul; Łukowska, Marta; Faivre, Nathan; Metzinger, Thomas; Serino, Andrea; Blanke, Olaf

    2017-09-01

    Recent studies have highlighted the role of multisensory integration as a key mechanism of self-consciousness. In particular, integration of bodily signals within the peripersonal space (PPS) underlies the experience of the self in a body we own (self-identification) and that is experienced as occupying a specific location in space (self-location), two main components of bodily self-consciousness (BSC). Experiments investigating the effects of multisensory integration on BSC have typically employed supra-threshold sensory stimuli, neglecting the role of unconscious sensory signals in BSC, as tested in other consciousness research. Here, we used psychophysical techniques to test whether multisensory integration of bodily stimuli underlying BSC also occurs for multisensory inputs presented below the threshold of conscious perception. Our results indicate that visual stimuli rendered invisible through continuous flash suppression boost processing of tactile stimuli on the body (Exp. 1), and enhance the perception of near-threshold tactile stimuli (Exp. 2), only once they entered PPS. We then employed unconscious multisensory stimulation to manipulate BSC. Participants were presented with tactile stimulation on their body and with visual stimuli on a virtual body, seen at a distance, which were either visible or rendered invisible. We found that participants reported higher self-identification with the virtual body in the synchronous visuo-tactile stimulation (as compared to asynchronous stimulation; Exp. 3), and shifted their self-location toward the virtual body (Exp.4), even if stimuli were fully invisible. Our results indicate that multisensory inputs, even outside of awareness, are integrated and affect the phenomenological content of self-consciousness, grounding BSC firmly in the field of psychophysical consciousness studies. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. High dimensional model representation method for fuzzy structural dynamics

    Science.gov (United States)

    Adhikari, S.; Chowdhury, R.; Friswell, M. I.

    2011-03-01

    Uncertainty propagation in multi-parameter complex structures possess significant computational challenges. This paper investigates the possibility of using the High Dimensional Model Representation (HDMR) approach when uncertain system parameters are modeled using fuzzy variables. In particular, the application of HDMR is proposed for fuzzy finite element analysis of linear dynamical systems. The HDMR expansion is an efficient formulation for high-dimensional mapping in complex systems if the higher order variable correlations are weak, thereby permitting the input-output relationship behavior to be captured by the terms of low-order. The computational effort to determine the expansion functions using the α-cut method scales polynomically with the number of variables rather than exponentially. This logic is based on the fundamental assumption underlying the HDMR representation that only low-order correlations among the input variables are likely to have significant impacts upon the outputs for most high-dimensional complex systems. The proposed method is first illustrated for multi-parameter nonlinear mathematical test functions with fuzzy variables. The method is then integrated with a commercial finite element software (ADINA). Modal analysis of a simplified aircraft wing with fuzzy parameters has been used to illustrate the generality of the proposed approach. In the numerical examples, triangular membership functions have been used and the results have been validated against direct Monte Carlo simulations. It is shown that using the proposed HDMR approach, the number of finite element function calls can be reduced without significantly compromising the accuracy.

  17. A latent low-dimensional common input drives a pool of motor neurons: a probabilistic latent state-space model.

    Science.gov (United States)

    Feeney, Daniel F; Meyer, François G; Noone, Nicholas; Enoka, Roger M

    2017-10-01

    Motor neurons appear to be activated with a common input signal that modulates the discharge activity of all neurons in the motor nucleus. It has proven difficult for neurophysiologists to quantify the variability in a common input signal, but characterization of such a signal may improve our understanding of how the activation signal varies across motor tasks. Contemporary methods of quantifying the common input to motor neurons rely on compiling discrete action potentials into continuous time series, assuming the motor pool acts as a linear filter, and requiring signals to be of sufficient duration for frequency analysis. We introduce a space-state model in which the discharge activity of motor neurons is modeled as inhomogeneous Poisson processes and propose a method to quantify an abstract latent trajectory that represents the common input received by motor neurons. The approach also approximates the variation in synaptic noise in the common input signal. The model is validated with four data sets: a simulation of 120 motor units, a pair of integrate-and-fire neurons with a Renshaw cell providing inhibitory feedback, the discharge activity of 10 integrate-and-fire neurons, and the discharge times of concurrently active motor units during an isometric voluntary contraction. The simulations revealed that a latent state-space model is able to quantify the trajectory and variability of the common input signal across all four conditions. When compared with the cumulative spike train method of characterizing common input, the state-space approach was more sensitive to the details of the common input current and was less influenced by the duration of the signal. The state-space approach appears to be capable of detecting rather modest changes in common input signals across conditions. NEW & NOTEWORTHY We propose a state-space model that explicitly delineates a common input signal sent to motor neurons and the physiological noise inherent in synaptic signal

  18. Modeling High-Dimensional Multichannel Brain Signals

    KAUST Repository

    Hu, Lechuan; Fortin, Norbert J.; Ombao, Hernando

    2017-01-01

    aspects: first, there are major statistical and computational challenges for modeling and analyzing high-dimensional multichannel brain signals; second, there is no set of universally agreed measures for characterizing connectivity. To model multichannel

  19. Influence of the input database in detecting fire space-time clusters

    Science.gov (United States)

    Pereira, Mário; Costa, Ricardo; Tonini, Marj; Vega Orozco, Carmen; Parente, Joana

    2015-04-01

    Fire incidence variability is influenced by local environmental variables such as topography, land use, vegetation and weather conditions. These induce a cluster pattern of the fire events distribution. The space-time permutation scan statistics (STPSS) method developed by Kulldorff et al. (2005) and implemented in the SaTScanTM software (http://www.satscan.org/) proves to be able to detect space-time clusters in many different fields, even when using incomplete and/or inaccurate input data. Nevertheless, the dependence of the STPSS method on the different characteristics of different datasets describing the same environmental phenomenon has not been studied yet. In this sense, the objective of this study is to assess the robustness of the STPSS for detecting real clusters using different input datasets and to justify the obtained results. This study takes advantage of the existence of two very different official fire datasets currently available for Portugal, both provided by the Institute for the Conservation of Nature and Forests. The first one is the aggregated Portuguese Rural Fire Database PRFD (Pereira et al., 2011), which is based on ground measurements and provides detailed information about the ignition and extinction date/time and the area burnt by each fire in forest, scrubs and agricultural areas. However, in the PRFD, the fire location of each fire is indicated by the name of smallest administrative unit (the parish) where the ignition occurred. Consequently, since the application of the STPSS requires the geographic coordinates of the events, the centroid of the parishes was considered. The second fire dataset is the national mapping burnt areas (NMBA), which is based on satellite measurements and delivered in shape file format. The NMBA provides a detailed spatial information (shape and size of each fire) but the temporal information is restricted to the year of occurrence. Besides these differences, the two datasets cover different periods, they

  20. Out-of-Sequence Prevention for Multicast Input-Queuing Space-Memory-Memory Clos-Network

    DEFF Research Database (Denmark)

    Yu, Hao; Ruepp, Sarah; Berger, Michael Stübert

    2011-01-01

    This paper proposes two cell dispatching algorithms for the input-queuing space-memory-memory (IQ-SMM) Closnetwork to reduce out-of-sequence (OOS) for multicast traffic. The frequent connection pattern change of DSRR results in a severe OOS problem. Based on the principle of DSRR, MFDSRR is able ...

  1. Out-of-Sequence Preventative Cell Dispatching for Multicast Input-Queued Space-Memory-Memory Clos-Network

    DEFF Research Database (Denmark)

    Yu, Hao; Ruepp, Sarah Renée; Berger, Michael Stübert

    2011-01-01

    This paper proposes two out-of-sequence (OOS) preventative cell dispatching algorithms for the multicast input-queued space-memory-memory (IQ-SMM) Clos-network switch architecture, i.e. the multicast flow-based DSRR (MF-DSRR) and the multicast flow-based round-robin (MFRR). Treating each cell...

  2. Preventing Out-of-Sequence for Multicast Input-Queued Space-Memory-Memory Clos-Network

    DEFF Research Database (Denmark)

    Yu, Hao; Ruepp, Sarah Renée; Berger, Michael Stübert

    2011-01-01

    This paper proposes an out-of-sequence (OOS) preventative cell dispatching algorithm, the multicast flow-based round robin (MFRR), for multicast input-queued space-memory-memory (IQ-SMM) Clos-network architecture. Independently treating each incoming cell, such as the desynchronized static round...

  3. High-dimensional quantum cloning and applications to quantum hacking.

    Science.gov (United States)

    Bouchard, Frédéric; Fickler, Robert; Boyd, Robert W; Karimi, Ebrahim

    2017-02-01

    Attempts at cloning a quantum system result in the introduction of imperfections in the state of the copies. This is a consequence of the no-cloning theorem, which is a fundamental law of quantum physics and the backbone of security for quantum communications. Although perfect copies are prohibited, a quantum state may be copied with maximal accuracy via various optimal cloning schemes. Optimal quantum cloning, which lies at the border of the physical limit imposed by the no-signaling theorem and the Heisenberg uncertainty principle, has been experimentally realized for low-dimensional photonic states. However, an increase in the dimensionality of quantum systems is greatly beneficial to quantum computation and communication protocols. Nonetheless, no experimental demonstration of optimal cloning machines has hitherto been shown for high-dimensional quantum systems. We perform optimal cloning of high-dimensional photonic states by means of the symmetrization method. We show the universality of our technique by conducting cloning of numerous arbitrary input states and fully characterize our cloning machine by performing quantum state tomography on cloned photons. In addition, a cloning attack on a Bennett and Brassard (BB84) quantum key distribution protocol is experimentally demonstrated to reveal the robustness of high-dimensional states in quantum cryptography.

  4. High dimensional neurocomputing growth, appraisal and applications

    CERN Document Server

    Tripathi, Bipin Kumar

    2015-01-01

    The book presents a coherent understanding of computational intelligence from the perspective of what is known as "intelligent computing" with high-dimensional parameters. It critically discusses the central issue of high-dimensional neurocomputing, such as quantitative representation of signals, extending the dimensionality of neuron, supervised and unsupervised learning and design of higher order neurons. The strong point of the book is its clarity and ability of the underlying theory to unify our understanding of high-dimensional computing where conventional methods fail. The plenty of application oriented problems are presented for evaluating, monitoring and maintaining the stability of adaptive learning machine. Author has taken care to cover the breadth and depth of the subject, both in the qualitative as well as quantitative way. The book is intended to enlighten the scientific community, ranging from advanced undergraduates to engineers, scientists and seasoned researchers in computational intelligenc...

  5. Identifying the relevant dependencies of the neural network response on characteristics of the input space

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    This talk presents an approach to identify those characteristics of the neural network inputs that are most relevant for the response and therefore provides essential information to determine the systematic uncertainties.

  6. Asymptotically Honest Confidence Regions for High Dimensional

    DEFF Research Database (Denmark)

    Caner, Mehmet; Kock, Anders Bredahl

    While variable selection and oracle inequalities for the estimation and prediction error have received considerable attention in the literature on high-dimensional models, very little work has been done in the area of testing and construction of confidence bands in high-dimensional models. However...... develop an oracle inequality for the conservative Lasso only assuming the existence of a certain number of moments. This is done by means of the Marcinkiewicz-Zygmund inequality which in our context provides sharper bounds than Nemirovski's inequality. As opposed to van de Geer et al. (2014) we allow...

  7. High Dimensional Classification Using Features Annealed Independence Rules.

    Science.gov (United States)

    Fan, Jianqing; Fan, Yingying

    2008-01-01

    Classification using high-dimensional features arises frequently in many contemporary statistical studies such as tumor classification using microarray or other high-throughput data. The impact of dimensionality on classifications is largely poorly understood. In a seminal paper, Bickel and Levina (2004) show that the Fisher discriminant performs poorly due to diverging spectra and they propose to use the independence rule to overcome the problem. We first demonstrate that even for the independence classification rule, classification using all the features can be as bad as the random guessing due to noise accumulation in estimating population centroids in high-dimensional feature space. In fact, we demonstrate further that almost all linear discriminants can perform as bad as the random guessing. Thus, it is paramountly important to select a subset of important features for high-dimensional classification, resulting in Features Annealed Independence Rules (FAIR). The conditions under which all the important features can be selected by the two-sample t-statistic are established. The choice of the optimal number of features, or equivalently, the threshold value of the test statistics are proposed based on an upper bound of the classification error. Simulation studies and real data analysis support our theoretical results and demonstrate convincingly the advantage of our new classification procedure.

  8. OpenAnalogInput(): Hybrid Spaces, Self-Making and Power in the Internet of Things

    Science.gov (United States)

    Duarte, Fernanda da Costa Portugal

    2015-01-01

    This dissertation investigates how the emergence of the Internet of Things and the embeddedness of sensors and networked connectivity onto things, physical spaces and biological bodies rearticulates embodied spaces, devises practices of self-making and forms of power in the governance of the self and society. (Abstract shortened by ProQuest.).…

  9. State Estimation of International Space Station Centrifuge Rotor With Incomplete Knowledge of Disturbance Inputs

    National Research Council Canada - National Science Library

    Sullivan, Michael J

    2005-01-01

    This thesis develops a state estimation algorithm for the Centrifuge Rotor (CR) system where only relative measurements are available with limited knowledge of both rotor imbalance disturbances and International Space Station (ISS...

  10. The additive hazards model with high-dimensional regressors

    DEFF Research Database (Denmark)

    Martinussen, Torben; Scheike, Thomas

    2009-01-01

    This paper considers estimation and prediction in the Aalen additive hazards model in the case where the covariate vector is high-dimensional such as gene expression measurements. Some form of dimension reduction of the covariate space is needed to obtain useful statistical analyses. We study...... model. A standard PLS algorithm can also be constructed, but it turns out that the resulting predictor can only be related to the original covariates via time-dependent coefficients. The methods are applied to a breast cancer data set with gene expression recordings and to the well known primary biliary...

  11. Introduction to high-dimensional statistics

    CERN Document Server

    Giraud, Christophe

    2015-01-01

    Ever-greater computing technologies have given rise to an exponentially growing volume of data. Today massive data sets (with potentially thousands of variables) play an important role in almost every branch of modern human activity, including networks, finance, and genetics. However, analyzing such data has presented a challenge for statisticians and data analysts and has required the development of new statistical methods capable of separating the signal from the noise.Introduction to High-Dimensional Statistics is a concise guide to state-of-the-art models, techniques, and approaches for ha

  12. Estimating High-Dimensional Time Series Models

    DEFF Research Database (Denmark)

    Medeiros, Marcelo C.; Mendes, Eduardo F.

    We study the asymptotic properties of the Adaptive LASSO (adaLASSO) in sparse, high-dimensional, linear time-series models. We assume both the number of covariates in the model and candidate variables can increase with the number of observations and the number of candidate variables is, possibly......, larger than the number of observations. We show the adaLASSO consistently chooses the relevant variables as the number of observations increases (model selection consistency), and has the oracle property, even when the errors are non-Gaussian and conditionally heteroskedastic. A simulation study shows...

  13. High dimensional classifiers in the imbalanced case

    DEFF Research Database (Denmark)

    Bak, Britta Anker; Jensen, Jens Ledet

    We consider the binary classification problem in the imbalanced case where the number of samples from the two groups differ. The classification problem is considered in the high dimensional case where the number of variables is much larger than the number of samples, and where the imbalance leads...... to a bias in the classification. A theoretical analysis of the independence classifier reveals the origin of the bias and based on this we suggest two new classifiers that can handle any imbalance ratio. The analytical results are supplemented by a simulation study, where the suggested classifiers in some...

  14. Topology of high-dimensional manifolds

    Energy Technology Data Exchange (ETDEWEB)

    Farrell, F T [State University of New York, Binghamton (United States); Goettshe, L [Abdus Salam ICTP, Trieste (Italy); Lueck, W [Westfaelische Wilhelms-Universitaet Muenster, Muenster (Germany)

    2002-08-15

    The School on High-Dimensional Manifold Topology took place at the Abdus Salam ICTP, Trieste from 21 May 2001 to 8 June 2001. The focus of the school was on the classification of manifolds and related aspects of K-theory, geometry, and operator theory. The topics covered included: surgery theory, algebraic K- and L-theory, controlled topology, homology manifolds, exotic aspherical manifolds, homeomorphism and diffeomorphism groups, and scalar curvature. The school consisted of 2 weeks of lecture courses and one week of conference. Thwo-part lecture notes volume contains the notes of most of the lecture courses.

  15. Elucidating high-dimensional cancer hallmark annotation via enriched ontology.

    Science.gov (United States)

    Yan, Shankai; Wong, Ka-Chun

    2017-09-01

    Cancer hallmark annotation is a promising technique that could discover novel knowledge about cancer from the biomedical literature. The automated annotation of cancer hallmarks could reveal relevant cancer transformation processes in the literature or extract the articles that correspond to the cancer hallmark of interest. It acts as a complementary approach that can retrieve knowledge from massive text information, advancing numerous focused studies in cancer research. Nonetheless, the high-dimensional nature of cancer hallmark annotation imposes a unique challenge. To address the curse of dimensionality, we compared multiple cancer hallmark annotation methods on 1580 PubMed abstracts. Based on the insights, a novel approach, UDT-RF, which makes use of ontological features is proposed. It expands the feature space via the Medical Subject Headings (MeSH) ontology graph and utilizes novel feature selections for elucidating the high-dimensional cancer hallmark annotation space. To demonstrate its effectiveness, state-of-the-art methods are compared and evaluated by a multitude of performance metrics, revealing the full performance spectrum on the full set of cancer hallmarks. Several case studies are conducted, demonstrating how the proposed approach could reveal novel insights into cancers. https://github.com/cskyan/chmannot. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. On the average complexity of sphere decoding in lattice space-time coded multiple-input multiple-output channel

    KAUST Repository

    Abediseid, Walid

    2012-12-21

    The exact average complexity analysis of the basic sphere decoder for general space-time codes applied to multiple-input multiple-output (MIMO) wireless channel is known to be difficult. In this work, we shed the light on the computational complexity of sphere decoding for the quasi- static, lattice space-time (LAST) coded MIMO channel. Specifically, we drive an upper bound of the tail distribution of the decoder\\'s computational complexity. We show that when the computational complexity exceeds a certain limit, this upper bound becomes dominated by the outage probability achieved by LAST coding and sphere decoding schemes. We then calculate the minimum average computational complexity that is required by the decoder to achieve near optimal performance in terms of the system parameters. Our results indicate that there exists a cut-off rate (multiplexing gain) for which the average complexity remains bounded. Copyright © 2012 John Wiley & Sons, Ltd.

  17. Non-intrusive low-rank separated approximation of high-dimensional stochastic models

    KAUST Repository

    Doostan, Alireza; Validi, AbdoulAhad; Iaccarino, Gianluca

    2013-01-01

    This work proposes a sampling-based (non-intrusive) approach within the context of low-. rank separated representations to tackle the issue of curse-of-dimensionality associated with the solution of models, e.g., PDEs/ODEs, with high-dimensional random inputs. Under some conditions discussed in details, the number of random realizations of the solution, required for a successful approximation, grows linearly with respect to the number of random inputs. The construction of the separated representation is achieved via a regularized alternating least-squares regression, together with an error indicator to estimate model parameters. The computational complexity of such a construction is quadratic in the number of random inputs. The performance of the method is investigated through its application to three numerical examples including two ODE problems with high-dimensional random inputs. © 2013 Elsevier B.V.

  18. Non-intrusive low-rank separated approximation of high-dimensional stochastic models

    KAUST Repository

    Doostan, Alireza

    2013-08-01

    This work proposes a sampling-based (non-intrusive) approach within the context of low-. rank separated representations to tackle the issue of curse-of-dimensionality associated with the solution of models, e.g., PDEs/ODEs, with high-dimensional random inputs. Under some conditions discussed in details, the number of random realizations of the solution, required for a successful approximation, grows linearly with respect to the number of random inputs. The construction of the separated representation is achieved via a regularized alternating least-squares regression, together with an error indicator to estimate model parameters. The computational complexity of such a construction is quadratic in the number of random inputs. The performance of the method is investigated through its application to three numerical examples including two ODE problems with high-dimensional random inputs. © 2013 Elsevier B.V.

  19. Approximating high-dimensional dynamics by barycentric coordinates with linear programming

    Energy Technology Data Exchange (ETDEWEB)

    Hirata, Yoshito, E-mail: yoshito@sat.t.u-tokyo.ac.jp; Aihara, Kazuyuki; Suzuki, Hideyuki [Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 (Japan); Department of Mathematical Informatics, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656 (Japan); CREST, JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan); Shiro, Masanori [Department of Mathematical Informatics, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656 (Japan); Mathematical Neuroinformatics Group, Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8568 (Japan); Takahashi, Nozomu; Mas, Paloma [Center for Research in Agricultural Genomics (CRAG), Consorci CSIC-IRTA-UAB-UB, Barcelona 08193 (Spain)

    2015-01-15

    The increasing development of novel methods and techniques facilitates the measurement of high-dimensional time series but challenges our ability for accurate modeling and predictions. The use of a general mathematical model requires the inclusion of many parameters, which are difficult to be fitted for relatively short high-dimensional time series observed. Here, we propose a novel method to accurately model a high-dimensional time series. Our method extends the barycentric coordinates to high-dimensional phase space by employing linear programming, and allowing the approximation errors explicitly. The extension helps to produce free-running time-series predictions that preserve typical topological, dynamical, and/or geometric characteristics of the underlying attractors more accurately than the radial basis function model that is widely used. The method can be broadly applied, from helping to improve weather forecasting, to creating electronic instruments that sound more natural, and to comprehensively understanding complex biological data.

  20. Approximating high-dimensional dynamics by barycentric coordinates with linear programming

    International Nuclear Information System (INIS)

    Hirata, Yoshito; Aihara, Kazuyuki; Suzuki, Hideyuki; Shiro, Masanori; Takahashi, Nozomu; Mas, Paloma

    2015-01-01

    The increasing development of novel methods and techniques facilitates the measurement of high-dimensional time series but challenges our ability for accurate modeling and predictions. The use of a general mathematical model requires the inclusion of many parameters, which are difficult to be fitted for relatively short high-dimensional time series observed. Here, we propose a novel method to accurately model a high-dimensional time series. Our method extends the barycentric coordinates to high-dimensional phase space by employing linear programming, and allowing the approximation errors explicitly. The extension helps to produce free-running time-series predictions that preserve typical topological, dynamical, and/or geometric characteristics of the underlying attractors more accurately than the radial basis function model that is widely used. The method can be broadly applied, from helping to improve weather forecasting, to creating electronic instruments that sound more natural, and to comprehensively understanding complex biological data

  1. Approximating high-dimensional dynamics by barycentric coordinates with linear programming.

    Science.gov (United States)

    Hirata, Yoshito; Shiro, Masanori; Takahashi, Nozomu; Aihara, Kazuyuki; Suzuki, Hideyuki; Mas, Paloma

    2015-01-01

    The increasing development of novel methods and techniques facilitates the measurement of high-dimensional time series but challenges our ability for accurate modeling and predictions. The use of a general mathematical model requires the inclusion of many parameters, which are difficult to be fitted for relatively short high-dimensional time series observed. Here, we propose a novel method to accurately model a high-dimensional time series. Our method extends the barycentric coordinates to high-dimensional phase space by employing linear programming, and allowing the approximation errors explicitly. The extension helps to produce free-running time-series predictions that preserve typical topological, dynamical, and/or geometric characteristics of the underlying attractors more accurately than the radial basis function model that is widely used. The method can be broadly applied, from helping to improve weather forecasting, to creating electronic instruments that sound more natural, and to comprehensively understanding complex biological data.

  2. Clustering high dimensional data using RIA

    Energy Technology Data Exchange (ETDEWEB)

    Aziz, Nazrina [School of Quantitative Sciences, College of Arts and Sciences, Universiti Utara Malaysia, 06010 Sintok, Kedah (Malaysia)

    2015-05-15

    Clustering may simply represent a convenient method for organizing a large data set so that it can easily be understood and information can efficiently be retrieved. However, identifying cluster in high dimensionality data sets is a difficult task because of the curse of dimensionality. Another challenge in clustering is some traditional functions cannot capture the pattern dissimilarity among objects. In this article, we used an alternative dissimilarity measurement called Robust Influence Angle (RIA) in the partitioning method. RIA is developed using eigenstructure of the covariance matrix and robust principal component score. We notice that, it can obtain cluster easily and hence avoid the curse of dimensionality. It is also manage to cluster large data sets with mixed numeric and categorical value.

  3. Evolution of Boolean networks under selection for a robust response to external inputs yields an extensive neutral space

    Science.gov (United States)

    Szejka, Agnes; Drossel, Barbara

    2010-02-01

    We study the evolution of Boolean networks as model systems for gene regulation. Inspired by biological networks, we select simultaneously for robust attractors and for the ability to respond to external inputs by changing the attractor. Mutations change the connections between the nodes and the update functions. In order to investigate the influence of the type of update functions, we perform our simulations with canalizing as well as with threshold functions. We compare the properties of the fitness landscapes that result for different versions of the selection criterion and the update functions. We find that for all studied cases the fitness landscape has a plateau with maximum fitness resulting in the fact that structurally very different networks are able to fulfill the same task and are connected by neutral paths in network (“genotype”) space. We find furthermore a connection between the attractor length and the mutational robustness, and an extremely long memory of the initial evolutionary stage.

  4. Machine learning for toxicity characterization of organic chemical emissions using USEtox database: Learning the structure of the input space.

    Science.gov (United States)

    Marvuglia, Antonino; Kanevski, Mikhail; Benetto, Enrico

    2015-10-01

    Toxicity characterization of chemical emissions in Life Cycle Assessment (LCA) is a complex task which usually proceeds via multimedia (fate, exposure and effect) models attached to models of dose-response relationships to assess the effects on target. Different models and approaches do exist, but all require a vast amount of data on the properties of the chemical compounds being assessed, which are hard to collect or hardly publicly available (especially for thousands of less common or newly developed chemicals), therefore hampering in practice the assessment in LCA. An example is USEtox, a consensual model for the characterization of human toxicity and freshwater ecotoxicity. This paper places itself in a line of research aiming at providing a methodology to reduce the number of input parameters necessary to run multimedia fate models, focusing in particular to the application of the USEtox toxicity model. By focusing on USEtox, in this paper two main goals are pursued: 1) performing an extensive exploratory analysis (using dimensionality reduction techniques) of the input space constituted by the substance-specific properties at the aim of detecting particular patterns in the data manifold and estimating the dimension of the subspace in which the data manifold actually lies; and 2) exploring the application of a set of linear models, based on partial least squares (PLS) regression, as well as a nonlinear model (general regression neural network--GRNN) in the seek for an automatic selection strategy of the most informative variables according to the modelled output (USEtox factor). After extensive analysis, the intrinsic dimension of the input manifold has been identified between three and four. The variables selected as most informative may vary according to the output modelled and the model used, but for the toxicity factors modelled in this paper the input variables selected as most informative are coherent with prior expectations based on scientific knowledge

  5. Evaluating Clustering in Subspace Projections of High Dimensional Data

    DEFF Research Database (Denmark)

    Müller, Emmanuel; Günnemann, Stephan; Assent, Ira

    2009-01-01

    Clustering high dimensional data is an emerging research field. Subspace clustering or projected clustering group similar objects in subspaces, i.e. projections, of the full space. In the past decade, several clustering paradigms have been developed in parallel, without thorough evaluation...... and comparison between these paradigms on a common basis. Conclusive evaluation and comparison is challenged by three major issues. First, there is no ground truth that describes the "true" clusters in real world data. Second, a large variety of evaluation measures have been used that reflect different aspects...... of the clustering result. Finally, in typical publications authors have limited their analysis to their favored paradigm only, while paying other paradigms little or no attention. In this paper, we take a systematic approach to evaluate the major paradigms in a common framework. We study representative clustering...

  6. TSAR: a program for automatic resonance assignment using 2D cross-sections of high dimensionality, high-resolution spectra

    Energy Technology Data Exchange (ETDEWEB)

    Zawadzka-Kazimierczuk, Anna; Kozminski, Wiktor [University of Warsaw, Faculty of Chemistry (Poland); Billeter, Martin, E-mail: martin.billeter@chem.gu.se [University of Gothenburg, Biophysics Group, Department of Chemistry and Molecular Biology (Sweden)

    2012-09-15

    While NMR studies of proteins typically aim at structure, dynamics or interactions, resonance assignments represent in almost all cases the initial step of the analysis. With increasing complexity of the NMR spectra, for example due to decreasing extent of ordered structure, this task often becomes both difficult and time-consuming, and the recording of high-dimensional data with high-resolution may be essential. Random sampling of the evolution time space, combined with sparse multidimensional Fourier transform (SMFT), allows for efficient recording of very high dimensional spectra ({>=}4 dimensions) while maintaining high resolution. However, the nature of this data demands for automation of the assignment process. Here we present the program TSAR (Tool for SMFT-based Assignment of Resonances), which exploits all advantages of SMFT input. Moreover, its flexibility allows to process data from any type of experiments that provide sequential connectivities. The algorithm was tested on several protein samples, including a disordered 81-residue fragment of the {delta} subunit of RNA polymerase from Bacillus subtilis containing various repetitive sequences. For our test examples, TSAR achieves a high percentage of assigned residues without any erroneous assignments.

  7. High-dimensional orbital angular momentum entanglement concentration based on Laguerre–Gaussian mode selection

    International Nuclear Information System (INIS)

    Zhang, Wuhong; Su, Ming; Wu, Ziwen; Lu, Meng; Huang, Bingwei; Chen, Lixiang

    2013-01-01

    Twisted photons enable the definition of a Hilbert space beyond two dimensions by orbital angular momentum (OAM) eigenstates. Here we propose a feasible entanglement concentration experiment, to enhance the quality of high-dimensional entanglement shared by twisted photon pairs. Our approach is started from the full characterization of entangled spiral bandwidth, and is then based on the careful selection of the Laguerre–Gaussian (LG) modes with specific radial and azimuthal indices p and ℓ. In particular, we demonstrate the possibility of high-dimensional entanglement concentration residing in the OAM subspace of up to 21 dimensions. By means of LabVIEW simulations with spatial light modulators, we show that the Shannon dimensionality could be employed to quantify the quality of the present concentration. Our scheme holds promise in quantum information applications defined in high-dimensional Hilbert space. (letter)

  8. Detection of Subtle Context-Dependent Model Inaccuracies in High-Dimensional Robot Domains.

    Science.gov (United States)

    Mendoza, Juan Pablo; Simmons, Reid; Veloso, Manuela

    2016-12-01

    Autonomous robots often rely on models of their sensing and actions for intelligent decision making. However, when operating in unconstrained environments, the complexity of the world makes it infeasible to create models that are accurate in every situation. This article addresses the problem of using potentially large and high-dimensional sets of robot execution data to detect situations in which a robot model is inaccurate-that is, detecting context-dependent model inaccuracies in a high-dimensional context space. To find inaccuracies tractably, the robot conducts an informed search through low-dimensional projections of execution data to find parametric Regions of Inaccurate Modeling (RIMs). Empirical evidence from two robot domains shows that this approach significantly enhances the detection power of existing RIM-detection algorithms in high-dimensional spaces.

  9. Modeling High-Dimensional Multichannel Brain Signals

    KAUST Repository

    Hu, Lechuan

    2017-12-12

    Our goal is to model and measure functional and effective (directional) connectivity in multichannel brain physiological signals (e.g., electroencephalograms, local field potentials). The difficulties from analyzing these data mainly come from two aspects: first, there are major statistical and computational challenges for modeling and analyzing high-dimensional multichannel brain signals; second, there is no set of universally agreed measures for characterizing connectivity. To model multichannel brain signals, our approach is to fit a vector autoregressive (VAR) model with potentially high lag order so that complex lead-lag temporal dynamics between the channels can be captured. Estimates of the VAR model will be obtained by our proposed hybrid LASSLE (LASSO + LSE) method which combines regularization (to control for sparsity) and least squares estimation (to improve bias and mean-squared error). Then we employ some measures of connectivity but put an emphasis on partial directed coherence (PDC) which can capture the directional connectivity between channels. PDC is a frequency-specific measure that explains the extent to which the present oscillatory activity in a sender channel influences the future oscillatory activity in a specific receiver channel relative to all possible receivers in the network. The proposed modeling approach provided key insights into potential functional relationships among simultaneously recorded sites during performance of a complex memory task. Specifically, this novel method was successful in quantifying patterns of effective connectivity across electrode locations, and in capturing how these patterns varied across trial epochs and trial types.

  10. Explorations on High Dimensional Landscapes: Spin Glasses and Deep Learning

    Science.gov (United States)

    Sagun, Levent

    This thesis deals with understanding the structure of high-dimensional and non-convex energy landscapes. In particular, its focus is on the optimization of two classes of functions: homogeneous polynomials and loss functions that arise in machine learning. In the first part, the notion of complexity of a smooth, real-valued function is studied through its critical points. Existing theoretical results predict that certain random functions that are defined on high dimensional domains have a narrow band of values whose pre-image contains the bulk of its critical points. This section provides empirical evidence for convergence of gradient descent to local minima whose energies are near the predicted threshold justifying the existing asymptotic theory. Moreover, it is empirically shown that a similar phenomenon may hold for deep learning loss functions. Furthermore, there is a comparative analysis of gradient descent and its stochastic version showing that in high dimensional regimes the latter is a mere speedup. The next study focuses on the halting time of an algorithm at a given stopping condition. Given an algorithm, the normalized fluctuations of the halting time follow a distribution that remains unchanged even when the input data is sampled from a new distribution. Two qualitative classes are observed: a Gumbel-like distribution that appears in Google searches, human decision times, and spin glasses and a Gaussian-like distribution that appears in conjugate gradient method, deep learning with MNIST and random input data. Following the universality phenomenon, the Hessian of the loss functions of deep learning is studied. The spectrum is seen to be composed of two parts, the bulk which is concentrated around zero, and the edges which are scattered away from zero. Empirical evidence is presented for the bulk indicating how over-parametrized the system is, and for the edges that depend on the input data. Furthermore, an algorithm is proposed such that it would

  11. A qualitative numerical study of high dimensional dynamical systems

    Science.gov (United States)

    Albers, David James

    Since Poincare, the father of modern mathematical dynamical systems, much effort has been exerted to achieve a qualitative understanding of the physical world via a qualitative understanding of the functions we use to model the physical world. In this thesis, we construct a numerical framework suitable for a qualitative, statistical study of dynamical systems using the space of artificial neural networks. We analyze the dynamics along intervals in parameter space, separating the set of neural networks into roughly four regions: the fixed point to the first bifurcation; the route to chaos; the chaotic region; and a transition region between chaos and finite-state neural networks. The study is primarily with respect to high-dimensional dynamical systems. We make the following general conclusions as the dimension of the dynamical system is increased: the probability of the first bifurcation being of type Neimark-Sacker is greater than ninety-percent; the most probable route to chaos is via a cascade of bifurcations of high-period periodic orbits, quasi-periodic orbits, and 2-tori; there exists an interval of parameter space such that hyperbolicity is violated on a countable, Lebesgue measure 0, "increasingly dense" subset; chaos is much more likely to persist with respect to parameter perturbation in the chaotic region of parameter space as the dimension is increased; moreover, as the number of positive Lyapunov exponents is increased, the likelihood that any significant portion of these positive exponents can be perturbed away decreases with increasing dimension. The maximum Kaplan-Yorke dimension and the maximum number of positive Lyapunov exponents increases linearly with dimension. The probability of a dynamical system being chaotic increases exponentially with dimension. The results with respect to the first bifurcation and the route to chaos comment on previous results of Newhouse, Ruelle, Takens, Broer, Chenciner, and Iooss. Moreover, results regarding the high-dimensional

  12. Variable kernel density estimation in high-dimensional feature spaces

    CSIR Research Space (South Africa)

    Van der Walt, Christiaan M

    2017-02-01

    Full Text Available Estimating the joint probability density function of a dataset is a central task in many machine learning applications. In this work we address the fundamental problem of kernel bandwidth estimation for variable kernel density estimation in high...

  13. High-Dimensional Quantum Information Processing with Linear Optics

    Science.gov (United States)

    Fitzpatrick, Casey A.

    Quantum information processing (QIP) is an interdisciplinary field concerned with the development of computers and information processing systems that utilize quantum mechanical properties of nature to carry out their function. QIP systems have become vastly more practical since the turn of the century. Today, QIP applications span imaging, cryptographic security, computation, and simulation (quantum systems that mimic other quantum systems). Many important strategies improve quantum versions of classical information system hardware, such as single photon detectors and quantum repeaters. Another more abstract strategy engineers high-dimensional quantum state spaces, so that each successful event carries more information than traditional two-level systems allow. Photonic states in particular bring the added advantages of weak environmental coupling and data transmission near the speed of light, allowing for simpler control and lower system design complexity. In this dissertation, numerous novel, scalable designs for practical high-dimensional linear-optical QIP systems are presented. First, a correlated photon imaging scheme using orbital angular momentum (OAM) states to detect rotational symmetries in objects using measurements, as well as building images out of those interactions is reported. Then, a statistical detection method using chains of OAM superpositions distributed according to the Fibonacci sequence is established and expanded upon. It is shown that the approach gives rise to schemes for sorting, detecting, and generating the recursively defined high-dimensional states on which some quantum cryptographic protocols depend. Finally, an ongoing study based on a generalization of the standard optical multiport for applications in quantum computation and simulation is reported upon. The architecture allows photons to reverse momentum inside the device. This in turn enables realistic implementation of controllable linear-optical scattering vertices for

  14. High-Dimensional Intrinsic Interpolation Using Gaussian Process Regression and Diffusion Maps

    International Nuclear Information System (INIS)

    Thimmisetty, Charanraj A.; Ghanem, Roger G.; White, Joshua A.; Chen, Xiao

    2017-01-01

    This article considers the challenging task of estimating geologic properties of interest using a suite of proxy measurements. The current work recast this task as a manifold learning problem. In this process, this article introduces a novel regression procedure for intrinsic variables constrained onto a manifold embedded in an ambient space. The procedure is meant to sharpen high-dimensional interpolation by inferring non-linear correlations from the data being interpolated. The proposed approach augments manifold learning procedures with a Gaussian process regression. It first identifies, using diffusion maps, a low-dimensional manifold embedded in an ambient high-dimensional space associated with the data. It relies on the diffusion distance associated with this construction to define a distance function with which the data model is equipped. This distance metric function is then used to compute the correlation structure of a Gaussian process that describes the statistical dependence of quantities of interest in the high-dimensional ambient space. The proposed method is applicable to arbitrarily high-dimensional data sets. Here, it is applied to subsurface characterization using a suite of well log measurements. The predictions obtained in original, principal component, and diffusion space are compared using both qualitative and quantitative metrics. Considerable improvement in the prediction of the geological structural properties is observed with the proposed method.

  15. Finding and Visualizing Relevant Subspaces for Clustering High-Dimensional Astronomical Data Using Connected Morphological Operators

    NARCIS (Netherlands)

    Ferdosi, Bilkis J.; Buddelmeijer, Hugo; Trager, Scott; Wilkinson, Michael H.F.; Roerdink, Jos B.T.M.

    2010-01-01

    Data sets in astronomy are growing to enormous sizes. Modern astronomical surveys provide not only image data but also catalogues of millions of objects (stars, galaxies), each object with hundreds of associated parameters. Exploration of this very high-dimensional data space poses a huge challenge.

  16. Quality and efficiency in high dimensional Nearest neighbor search

    KAUST Repository

    Tao, Yufei; Yi, Ke; Sheng, Cheng; Kalnis, Panos

    2009-01-01

    Nearest neighbor (NN) search in high dimensional space is an important problem in many applications. Ideally, a practical solution (i) should be implementable in a relational database, and (ii) its query cost should grow sub-linearly with the dataset size, regardless of the data and query distributions. Despite the bulk of NN literature, no solution fulfills both requirements, except locality sensitive hashing (LSH). The existing LSH implementations are either rigorous or adhoc. Rigorous-LSH ensures good quality of query results, but requires expensive space and query cost. Although adhoc-LSH is more efficient, it abandons quality control, i.e., the neighbor it outputs can be arbitrarily bad. As a result, currently no method is able to ensure both quality and efficiency simultaneously in practice. Motivated by this, we propose a new access method called the locality sensitive B-tree (LSB-tree) that enables fast highdimensional NN search with excellent quality. The combination of several LSB-trees leads to a structure called the LSB-forest that ensures the same result quality as rigorous-LSH, but reduces its space and query cost dramatically. The LSB-forest also outperforms adhoc-LSH, even though the latter has no quality guarantee. Besides its appealing theoretical properties, the LSB-tree itself also serves as an effective index that consumes linear space, and supports efficient updates. Our extensive experiments confirm that the LSB-tree is faster than (i) the state of the art of exact NN search by two orders of magnitude, and (ii) the best (linear-space) method of approximate retrieval by an order of magnitude, and at the same time, returns neighbors with much better quality. © 2009 ACM.

  17. Model-based Clustering of High-Dimensional Data in Astrophysics

    Science.gov (United States)

    Bouveyron, C.

    2016-05-01

    The nature of data in Astrophysics has changed, as in other scientific fields, in the past decades due to the increase of the measurement capabilities. As a consequence, data are nowadays frequently of high dimensionality and available in mass or stream. Model-based techniques for clustering are popular tools which are renowned for their probabilistic foundations and their flexibility. However, classical model-based techniques show a disappointing behavior in high-dimensional spaces which is mainly due to their dramatical over-parametrization. The recent developments in model-based classification overcome these drawbacks and allow to efficiently classify high-dimensional data, even in the "small n / large p" situation. This work presents a comprehensive review of these recent approaches, including regularization-based techniques, parsimonious modeling, subspace classification methods and classification methods based on variable selection. The use of these model-based methods is also illustrated on real-world classification problems in Astrophysics using R packages.

  18. A Hybrid Semi-Supervised Anomaly Detection Model for High-Dimensional Data

    Directory of Open Access Journals (Sweden)

    Hongchao Song

    2017-01-01

    Full Text Available Anomaly detection, which aims to identify observations that deviate from a nominal sample, is a challenging task for high-dimensional data. Traditional distance-based anomaly detection methods compute the neighborhood distance between each observation and suffer from the curse of dimensionality in high-dimensional space; for example, the distances between any pair of samples are similar and each sample may perform like an outlier. In this paper, we propose a hybrid semi-supervised anomaly detection model for high-dimensional data that consists of two parts: a deep autoencoder (DAE and an ensemble k-nearest neighbor graphs- (K-NNG- based anomaly detector. Benefiting from the ability of nonlinear mapping, the DAE is first trained to learn the intrinsic features of a high-dimensional dataset to represent the high-dimensional data in a more compact subspace. Several nonparametric KNN-based anomaly detectors are then built from different subsets that are randomly sampled from the whole dataset. The final prediction is made by all the anomaly detectors. The performance of the proposed method is evaluated on several real-life datasets, and the results confirm that the proposed hybrid model improves the detection accuracy and reduces the computational complexity.

  19. Ergodic channel capacity of spatial correlated multiple-input multiple-output free space optical links using multipulse pulse-position modulation

    Science.gov (United States)

    Wang, Huiqin; Wang, Xue; Cao, Minghua

    2017-02-01

    The spatial correlation extensively exists in the multiple-input multiple-output (MIMO) free space optical (FSO) communication systems due to the channel fading and the antenna space limitation. Wilkinson's method was utilized to investigate the impact of spatial correlation on the MIMO FSO communication system employing multipulse pulse-position modulation. Simulation results show that the existence of spatial correlation reduces the ergodic channel capacity, and the reception diversity is more competent to resist this kind of performance degradation.

  20. High-Dimensional Function Approximation With Neural Networks for Large Volumes of Data.

    Science.gov (United States)

    Andras, Peter

    2018-02-01

    Approximation of high-dimensional functions is a challenge for neural networks due to the curse of dimensionality. Often the data for which the approximated function is defined resides on a low-dimensional manifold and in principle the approximation of the function over this manifold should improve the approximation performance. It has been show that projecting the data manifold into a lower dimensional space, followed by the neural network approximation of the function over this space, provides a more precise approximation of the function than the approximation of the function with neural networks in the original data space. However, if the data volume is very large, the projection into the low-dimensional space has to be based on a limited sample of the data. Here, we investigate the nature of the approximation error of neural networks trained over the projection space. We show that such neural networks should have better approximation performance than neural networks trained on high-dimensional data even if the projection is based on a relatively sparse sample of the data manifold. We also find that it is preferable to use a uniformly distributed sparse sample of the data for the purpose of the generation of the low-dimensional projection. We illustrate these results considering the practical neural network approximation of a set of functions defined on high-dimensional data including real world data as well.

  1. Multivariate statistics high-dimensional and large-sample approximations

    CERN Document Server

    Fujikoshi, Yasunori; Shimizu, Ryoichi

    2010-01-01

    A comprehensive examination of high-dimensional analysis of multivariate methods and their real-world applications Multivariate Statistics: High-Dimensional and Large-Sample Approximations is the first book of its kind to explore how classical multivariate methods can be revised and used in place of conventional statistical tools. Written by prominent researchers in the field, the book focuses on high-dimensional and large-scale approximations and details the many basic multivariate methods used to achieve high levels of accuracy. The authors begin with a fundamental presentation of the basic

  2. Hierarchical low-rank approximation for high dimensional approximation

    KAUST Repository

    Nouy, Anthony

    2016-01-01

    Tensor methods are among the most prominent tools for the numerical solution of high-dimensional problems where functions of multiple variables have to be approximated. Such high-dimensional approximation problems naturally arise in stochastic analysis and uncertainty quantification. In many practical situations, the approximation of high-dimensional functions is made computationally tractable by using rank-structured approximations. In this talk, we present algorithms for the approximation in hierarchical tensor format using statistical methods. Sparse representations in a given tensor format are obtained with adaptive or convex relaxation methods, with a selection of parameters using crossvalidation methods.

  3. Hierarchical low-rank approximation for high dimensional approximation

    KAUST Repository

    Nouy, Anthony

    2016-01-07

    Tensor methods are among the most prominent tools for the numerical solution of high-dimensional problems where functions of multiple variables have to be approximated. Such high-dimensional approximation problems naturally arise in stochastic analysis and uncertainty quantification. In many practical situations, the approximation of high-dimensional functions is made computationally tractable by using rank-structured approximations. In this talk, we present algorithms for the approximation in hierarchical tensor format using statistical methods. Sparse representations in a given tensor format are obtained with adaptive or convex relaxation methods, with a selection of parameters using crossvalidation methods.

  4. Characterization of discontinuities in high-dimensional stochastic problems on adaptive sparse grids

    International Nuclear Information System (INIS)

    Jakeman, John D.; Archibald, Richard; Xiu Dongbin

    2011-01-01

    In this paper we present a set of efficient algorithms for detection and identification of discontinuities in high dimensional space. The method is based on extension of polynomial annihilation for discontinuity detection in low dimensions. Compared to the earlier work, the present method poses significant improvements for high dimensional problems. The core of the algorithms relies on adaptive refinement of sparse grids. It is demonstrated that in the commonly encountered cases where a discontinuity resides on a small subset of the dimensions, the present method becomes 'optimal', in the sense that the total number of points required for function evaluations depends linearly on the dimensionality of the space. The details of the algorithms will be presented and various numerical examples are utilized to demonstrate the efficacy of the method.

  5. Can We Train Machine Learning Methods to Outperform the High-dimensional Propensity Score Algorithm?

    Science.gov (United States)

    Karim, Mohammad Ehsanul; Pang, Menglan; Platt, Robert W

    2018-03-01

    The use of retrospective health care claims datasets is frequently criticized for the lack of complete information on potential confounders. Utilizing patient's health status-related information from claims datasets as surrogates or proxies for mismeasured and unobserved confounders, the high-dimensional propensity score algorithm enables us to reduce bias. Using a previously published cohort study of postmyocardial infarction statin use (1998-2012), we compare the performance of the algorithm with a number of popular machine learning approaches for confounder selection in high-dimensional covariate spaces: random forest, least absolute shrinkage and selection operator, and elastic net. Our results suggest that, when the data analysis is done with epidemiologic principles in mind, machine learning methods perform as well as the high-dimensional propensity score algorithm. Using a plasmode framework that mimicked the empirical data, we also showed that a hybrid of machine learning and high-dimensional propensity score algorithms generally perform slightly better than both in terms of mean squared error, when a bias-based analysis is used.

  6. An Unbiased Distance-based Outlier Detection Approach for High-dimensional Data

    DEFF Research Database (Denmark)

    Nguyen, Hoang Vu; Gopalkrishnan, Vivekanand; Assent, Ira

    2011-01-01

    than a global property. Different from existing approaches, it is not grid-based and dimensionality unbiased. Thus, its performance is impervious to grid resolution as well as the curse of dimensionality. In addition, our approach ranks the outliers, allowing users to select the number of desired...... outliers, thus mitigating the issue of high false alarm rate. Extensive empirical studies on real datasets show that our approach efficiently and effectively detects outliers, even in high-dimensional spaces....

  7. Gaussian processes with built-in dimensionality reduction: Applications to high-dimensional uncertainty propagation

    International Nuclear Information System (INIS)

    Tripathy, Rohit; Bilionis, Ilias; Gonzalez, Marcial

    2016-01-01

    Uncertainty quantification (UQ) tasks, such as model calibration, uncertainty propagation, and optimization under uncertainty, typically require several thousand evaluations of the underlying computer codes. To cope with the cost of simulations, one replaces the real response surface with a cheap surrogate based, e.g., on polynomial chaos expansions, neural networks, support vector machines, or Gaussian processes (GP). However, the number of simulations required to learn a generic multivariate response grows exponentially as the input dimension increases. This curse of dimensionality can only be addressed, if the response exhibits some special structure that can be discovered and exploited. A wide range of physical responses exhibit a special structure known as an active subspace (AS). An AS is a linear manifold of the stochastic space characterized by maximal response variation. The idea is that one should first identify this low dimensional manifold, project the high-dimensional input onto it, and then link the projection to the output. If the dimensionality of the AS is low enough, then learning the link function is a much easier problem than the original problem of learning a high-dimensional function. The classic approach to discovering the AS requires gradient information, a fact that severely limits its applicability. Furthermore, and partly because of its reliance to gradients, it is not able to handle noisy observations. The latter is an essential trait if one wants to be able to propagate uncertainty through stochastic simulators, e.g., through molecular dynamics codes. In this work, we develop a probabilistic version of AS which is gradient-free and robust to observational noise. Our approach relies on a novel Gaussian process regression with built-in dimensionality reduction. In particular, the AS is represented as an orthogonal projection matrix that serves as yet another covariance function hyper-parameter to be estimated from the data. To train the

  8. Gaussian processes with built-in dimensionality reduction: Applications to high-dimensional uncertainty propagation

    Science.gov (United States)

    Tripathy, Rohit; Bilionis, Ilias; Gonzalez, Marcial

    2016-09-01

    Uncertainty quantification (UQ) tasks, such as model calibration, uncertainty propagation, and optimization under uncertainty, typically require several thousand evaluations of the underlying computer codes. To cope with the cost of simulations, one replaces the real response surface with a cheap surrogate based, e.g., on polynomial chaos expansions, neural networks, support vector machines, or Gaussian processes (GP). However, the number of simulations required to learn a generic multivariate response grows exponentially as the input dimension increases. This curse of dimensionality can only be addressed, if the response exhibits some special structure that can be discovered and exploited. A wide range of physical responses exhibit a special structure known as an active subspace (AS). An AS is a linear manifold of the stochastic space characterized by maximal response variation. The idea is that one should first identify this low dimensional manifold, project the high-dimensional input onto it, and then link the projection to the output. If the dimensionality of the AS is low enough, then learning the link function is a much easier problem than the original problem of learning a high-dimensional function. The classic approach to discovering the AS requires gradient information, a fact that severely limits its applicability. Furthermore, and partly because of its reliance to gradients, it is not able to handle noisy observations. The latter is an essential trait if one wants to be able to propagate uncertainty through stochastic simulators, e.g., through molecular dynamics codes. In this work, we develop a probabilistic version of AS which is gradient-free and robust to observational noise. Our approach relies on a novel Gaussian process regression with built-in dimensionality reduction. In particular, the AS is represented as an orthogonal projection matrix that serves as yet another covariance function hyper-parameter to be estimated from the data. To train the

  9. Gaussian processes with built-in dimensionality reduction: Applications to high-dimensional uncertainty propagation

    Energy Technology Data Exchange (ETDEWEB)

    Tripathy, Rohit, E-mail: rtripath@purdue.edu; Bilionis, Ilias, E-mail: ibilion@purdue.edu; Gonzalez, Marcial, E-mail: marcial-gonzalez@purdue.edu

    2016-09-15

    Uncertainty quantification (UQ) tasks, such as model calibration, uncertainty propagation, and optimization under uncertainty, typically require several thousand evaluations of the underlying computer codes. To cope with the cost of simulations, one replaces the real response surface with a cheap surrogate based, e.g., on polynomial chaos expansions, neural networks, support vector machines, or Gaussian processes (GP). However, the number of simulations required to learn a generic multivariate response grows exponentially as the input dimension increases. This curse of dimensionality can only be addressed, if the response exhibits some special structure that can be discovered and exploited. A wide range of physical responses exhibit a special structure known as an active subspace (AS). An AS is a linear manifold of the stochastic space characterized by maximal response variation. The idea is that one should first identify this low dimensional manifold, project the high-dimensional input onto it, and then link the projection to the output. If the dimensionality of the AS is low enough, then learning the link function is a much easier problem than the original problem of learning a high-dimensional function. The classic approach to discovering the AS requires gradient information, a fact that severely limits its applicability. Furthermore, and partly because of its reliance to gradients, it is not able to handle noisy observations. The latter is an essential trait if one wants to be able to propagate uncertainty through stochastic simulators, e.g., through molecular dynamics codes. In this work, we develop a probabilistic version of AS which is gradient-free and robust to observational noise. Our approach relies on a novel Gaussian process regression with built-in dimensionality reduction. In particular, the AS is represented as an orthogonal projection matrix that serves as yet another covariance function hyper-parameter to be estimated from the data. To train the

  10. Harnessing high-dimensional hyperentanglement through a biphoton frequency comb

    Science.gov (United States)

    Xie, Zhenda; Zhong, Tian; Shrestha, Sajan; Xu, Xinan; Liang, Junlin; Gong, Yan-Xiao; Bienfang, Joshua C.; Restelli, Alessandro; Shapiro, Jeffrey H.; Wong, Franco N. C.; Wei Wong, Chee

    2015-08-01

    Quantum entanglement is a fundamental resource for secure information processing and communications, and hyperentanglement or high-dimensional entanglement has been separately proposed for its high data capacity and error resilience. The continuous-variable nature of the energy-time entanglement makes it an ideal candidate for efficient high-dimensional coding with minimal limitations. Here, we demonstrate the first simultaneous high-dimensional hyperentanglement using a biphoton frequency comb to harness the full potential in both the energy and time domain. Long-postulated Hong-Ou-Mandel quantum revival is exhibited, with up to 19 time-bins and 96.5% visibilities. We further witness the high-dimensional energy-time entanglement through Franson revivals, observed periodically at integer time-bins, with 97.8% visibility. This qudit state is observed to simultaneously violate the generalized Bell inequality by up to 10.95 standard deviations while observing recurrent Clauser-Horne-Shimony-Holt S-parameters up to 2.76. Our biphoton frequency comb provides a platform for photon-efficient quantum communications towards the ultimate channel capacity through energy-time-polarization high-dimensional encoding.

  11. 78 FR 32241 - U.S. Air Force Seeks Industry Input for National Security Space Launch Assessment

    Science.gov (United States)

    2013-05-29

    ..., seeks industry views and perspectives to inform an on-going strategic National Security Space Launch... the U.S. Government. 2. What are the critical issues that concern current and prospective launch...

  12. On the average complexity of sphere decoding in lattice space-time coded multiple-input multiple-output channel

    KAUST Repository

    Abediseid, Walid

    2012-01-01

    complexity of sphere decoding for the quasi- static, lattice space-time (LAST) coded MIMO channel. Specifically, we drive an upper bound of the tail distribution of the decoder's computational complexity. We show that when the computational complexity exceeds

  13. Analysing spatially extended high-dimensional dynamics by recurrence plots

    Energy Technology Data Exchange (ETDEWEB)

    Marwan, Norbert, E-mail: marwan@pik-potsdam.de [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Kurths, Jürgen [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Humboldt Universität zu Berlin, Institut für Physik (Germany); Nizhny Novgorod State University, Department of Control Theory, Nizhny Novgorod (Russian Federation); Foerster, Saskia [GFZ German Research Centre for Geosciences, Section 1.4 Remote Sensing, Telegrafenberg, 14473 Potsdam (Germany)

    2015-05-08

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. In this letter we show the potential of selected recurrence plot measures for the investigation of even high-dimensional dynamics. We apply this method on spatially extended chaos, such as derived from the Lorenz96 model and show that the recurrence plot based measures can qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analysing satellite image time series of vegetation cover with contrasting dynamics as a spatially extended and potentially high-dimensional example from the real world. - Highlights: • We use recurrence plots for analysing partially extended dynamics. • We investigate the high-dimensional chaos of the Lorenz96 model. • The approach distinguishes different spatio-temporal dynamics. • We use the method for studying vegetation cover time series.

  14. Representing high-dimensional data to intelligent prostheses and other wearable assistive robots: A first comparison of tile coding and selective Kanerva coding.

    Science.gov (United States)

    Travnik, Jaden B; Pilarski, Patrick M

    2017-07-01

    Prosthetic devices have advanced in their capabilities and in the number and type of sensors included in their design. As the space of sensorimotor data available to a conventional or machine learning prosthetic control system increases in dimensionality and complexity, it becomes increasingly important that this data be represented in a useful and computationally efficient way. Well structured sensory data allows prosthetic control systems to make informed, appropriate control decisions. In this study, we explore the impact that increased sensorimotor information has on current machine learning prosthetic control approaches. Specifically, we examine the effect that high-dimensional sensory data has on the computation time and prediction performance of a true-online temporal-difference learning prediction method as embedded within a resource-limited upper-limb prosthesis control system. We present results comparing tile coding, the dominant linear representation for real-time prosthetic machine learning, with a newly proposed modification to Kanerva coding that we call selective Kanerva coding. In addition to showing promising results for selective Kanerva coding, our results confirm potential limitations to tile coding as the number of sensory input dimensions increases. To our knowledge, this study is the first to explicitly examine representations for realtime machine learning prosthetic devices in general terms. This work therefore provides an important step towards forming an efficient prosthesis-eye view of the world, wherein prompt and accurate representations of high-dimensional data may be provided to machine learning control systems within artificial limbs and other assistive rehabilitation technologies.

  15. Application and optimization of input parameter spaces in mass flow modelling: a case study with r.randomwalk and r.ranger

    Science.gov (United States)

    Krenn, Julia; Zangerl, Christian; Mergili, Martin

    2017-04-01

    r.randomwalk is a GIS-based, multi-functional, conceptual open source model application for forward and backward analyses of the propagation of mass flows. It relies on a set of empirically derived, uncertain input parameters. In contrast to many other tools, r.randomwalk accepts input parameter ranges (or, in case of two or more parameters, spaces) in order to directly account for these uncertainties. Parameter spaces represent a possibility to withdraw from discrete input values which in most cases are likely to be off target. r.randomwalk automatically performs multiple calculations with various parameter combinations in a given parameter space, resulting in the impact indicator index (III) which denotes the fraction of parameter value combinations predicting an impact on a given pixel. Still, there is a need to constrain the parameter space used for a certain process type or magnitude prior to performing forward calculations. This can be done by optimizing the parameter space in terms of bringing the model results in line with well-documented past events. As most existing parameter optimization algorithms are designed for discrete values rather than for ranges or spaces, the necessity for a new and innovative technique arises. The present study aims at developing such a technique and at applying it to derive guiding parameter spaces for the forward calculation of rock avalanches through back-calculation of multiple events. In order to automatize the work flow we have designed r.ranger, an optimization and sensitivity analysis tool for parameter spaces which can be directly coupled to r.randomwalk. With r.ranger we apply a nested approach where the total value range of each parameter is divided into various levels of subranges. All possible combinations of subranges of all parameters are tested for the performance of the associated pattern of III. Performance indicators are the area under the ROC curve (AUROC) and the factor of conservativeness (FoC). This

  16. Similarity-dissimilarity plot for visualization of high dimensional data in biomedical pattern classification.

    Science.gov (United States)

    Arif, Muhammad

    2012-06-01

    In pattern classification problems, feature extraction is an important step. Quality of features in discriminating different classes plays an important role in pattern classification problems. In real life, pattern classification may require high dimensional feature space and it is impossible to visualize the feature space if the dimension of feature space is greater than four. In this paper, we have proposed a Similarity-Dissimilarity plot which can project high dimensional space to a two dimensional space while retaining important characteristics required to assess the discrimination quality of the features. Similarity-dissimilarity plot can reveal information about the amount of overlap of features of different classes. Separable data points of different classes will also be visible on the plot which can be classified correctly using appropriate classifier. Hence, approximate classification accuracy can be predicted. Moreover, it is possible to know about whom class the misclassified data points will be confused by the classifier. Outlier data points can also be located on the similarity-dissimilarity plot. Various examples of synthetic data are used to highlight important characteristics of the proposed plot. Some real life examples from biomedical data are also used for the analysis. The proposed plot is independent of number of dimensions of the feature space.

  17. High-dimensional model estimation and model selection

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    I will review concepts and algorithms from high-dimensional statistics for linear model estimation and model selection. I will particularly focus on the so-called p>>n setting where the number of variables p is much larger than the number of samples n. I will focus mostly on regularized statistical estimators that produce sparse models. Important examples include the LASSO and its matrix extension, the Graphical LASSO, and more recent non-convex methods such as the TREX. I will show the applicability of these estimators in a diverse range of scientific applications, such as sparse interaction graph recovery and high-dimensional classification and regression problems in genomics.

  18. Supporting Dynamic Quantization for High-Dimensional Data Analytics.

    Science.gov (United States)

    Guzun, Gheorghi; Canahuate, Guadalupe

    2017-05-01

    Similarity searches are at the heart of exploratory data analysis tasks. Distance metrics are typically used to characterize the similarity between data objects represented as feature vectors. However, when the dimensionality of the data increases and the number of features is large, traditional distance metrics fail to distinguish between the closest and furthest data points. Localized distance functions have been proposed as an alternative to traditional distance metrics. These functions only consider dimensions close to query to compute the distance/similarity. Furthermore, in order to enable interactive explorations of high-dimensional data, indexing support for ad-hoc queries is needed. In this work we set up to investigate whether bit-sliced indices can be used for exploratory analytics such as similarity searches and data clustering for high-dimensional big-data. We also propose a novel dynamic quantization called Query dependent Equi-Depth (QED) quantization and show its effectiveness on characterizing high-dimensional similarity. When applying QED we observe improvements in kNN classification accuracy over traditional distance functions. Gheorghi Guzun and Guadalupe Canahuate. 2017. Supporting Dynamic Quantization for High-Dimensional Data Analytics. In Proceedings of Ex-ploreDB'17, Chicago, IL, USA, May 14-19, 2017, 6 pages. https://doi.org/http://dx.doi.org/10.1145/3077331.3077336.

  19. A hybridized K-means clustering approach for high dimensional ...

    African Journals Online (AJOL)

    International Journal of Engineering, Science and Technology ... Due to incredible growth of high dimensional dataset, conventional data base querying methods are inadequate to extract useful information, so researchers nowadays ... Recently cluster analysis is a popularly used data analysis method in number of areas.

  20. On Robust Information Extraction from High-Dimensional Data

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan

    2014-01-01

    Roč. 9, č. 1 (2014), s. 131-144 ISSN 1452-4864 Grant - others:GA ČR(CZ) GA13-01930S Institutional support: RVO:67985807 Keywords : data mining * high-dimensional data * robust econometrics * outliers * machine learning Subject RIV: IN - Informatics, Computer Science

  1. Inference in High-dimensional Dynamic Panel Data Models

    DEFF Research Database (Denmark)

    Kock, Anders Bredahl; Tang, Haihan

    We establish oracle inequalities for a version of the Lasso in high-dimensional fixed effects dynamic panel data models. The inequalities are valid for the coefficients of the dynamic and exogenous regressors. Separate oracle inequalities are derived for the fixed effects. Next, we show how one can...

  2. Pricing High-Dimensional American Options Using Local Consistency Conditions

    NARCIS (Netherlands)

    Berridge, S.J.; Schumacher, J.M.

    2004-01-01

    We investigate a new method for pricing high-dimensional American options. The method is of finite difference type but is also related to Monte Carlo techniques in that it involves a representative sampling of the underlying variables.An approximating Markov chain is built using this sampling and

  3. Irregular grid methods for pricing high-dimensional American options

    NARCIS (Netherlands)

    Berridge, S.J.

    2004-01-01

    This thesis proposes and studies numerical methods for pricing high-dimensional American options; important examples being basket options, Bermudan swaptions and real options. Four new methods are presented and analysed, both in terms of their application to various test problems, and in terms of

  4. Estimate of the largest Lyapunov characteristic exponent of a high dimensional atmospheric global circulation model: a sensitivity analysis

    International Nuclear Information System (INIS)

    Guerrieri, A.

    2009-01-01

    In this report the largest Lyapunov characteristic exponent of a high dimensional atmospheric global circulation model of intermediate complexity has been estimated numerically. A sensitivity analysis has been carried out by varying the equator-to-pole temperature difference, the space resolution and the value of some parameters employed by the model. Chaotic and non-chaotic regimes of circulation have been found. [it

  5. Case Study: Using The OMG SWRADIO Profile and SDR Forum Input for NASA's Space Telecommunications Radio System

    Science.gov (United States)

    Briones, Janette C.; Handler, Louis M.; Hall, Steve C.; Reinhart, Richard C.; Kacpura, Thomas J.

    2009-01-01

    The Space Telecommunication Radio System (STRS) standard is a Software Defined Radio (SDR) architecture standard developed by NASA. The goal of STRS is to reduce NASA s dependence on custom, proprietary architectures with unique and varying interfaces and hardware and support reuse of waveforms across platforms. The STRS project worked with members of the Object Management Group (OMG), Software Defined Radio Forum, and industry partners to leverage existing standards and knowledge. This collaboration included investigating the use of the OMG s Platform-Independent Model (PIM) SWRadio as the basis for an STRS PIM. This paper details the influence of the OMG technologies on the STRS update effort, findings in the STRS/SWRadio mapping, and provides a summary of the SDR Forum recommendations.

  6. High Dimensional Modulation and MIMO Techniques for Access Networks

    DEFF Research Database (Denmark)

    Binti Othman, Maisara

    Exploration of advanced modulation formats and multiplexing techniques for next generation optical access networks are of interest as promising solutions for delivering multiple services to end-users. This thesis addresses this from two different angles: high dimensionality carrierless...... the capacity per wavelength of the femto-cell network. Bit rate up to 1.59 Gbps with fiber-wireless transmission over 1 m air distance is demonstrated. The results presented in this thesis demonstrate the feasibility of high dimensionality CAP in increasing the number of dimensions and their potentially......) optical access network. 2 X 2 MIMO RoF employing orthogonal frequency division multiplexing (OFDM) with 5.6 GHz RoF signaling over all-vertical cavity surface emitting lasers (VCSEL) WDM passive optical networks (PONs). We have employed polarization division multiplexing (PDM) to further increase...

  7. HSM: Heterogeneous Subspace Mining in High Dimensional Data

    DEFF Research Database (Denmark)

    Müller, Emmanuel; Assent, Ira; Seidl, Thomas

    2009-01-01

    Heterogeneous data, i.e. data with both categorical and continuous values, is common in many databases. However, most data mining algorithms assume either continuous or categorical attributes, but not both. In high dimensional data, phenomena due to the "curse of dimensionality" pose additional...... challenges. Usually, due to locally varying relevance of attributes, patterns do not show across the full set of attributes. In this paper we propose HSM, which defines a new pattern model for heterogeneous high dimensional data. It allows data mining in arbitrary subsets of the attributes that are relevant...... for the respective patterns. Based on this model we propose an efficient algorithm, which is aware of the heterogeneity of the attributes. We extend an indexing structure for continuous attributes such that HSM indexing adapts to different attribute types. In our experiments we show that HSM efficiently mines...

  8. Analysis of chaos in high-dimensional wind power system.

    Science.gov (United States)

    Wang, Cong; Zhang, Hongli; Fan, Wenhui; Ma, Ping

    2018-01-01

    A comprehensive analysis on the chaos of a high-dimensional wind power system is performed in this study. A high-dimensional wind power system is more complex than most power systems. An 11-dimensional wind power system proposed by Huang, which has not been analyzed in previous studies, is investigated. When the systems are affected by external disturbances including single parameter and periodic disturbance, or its parameters changed, chaotic dynamics of the wind power system is analyzed and chaotic parameters ranges are obtained. Chaos existence is confirmed by calculation and analysis of all state variables' Lyapunov exponents and the state variable sequence diagram. Theoretical analysis and numerical simulations show that the wind power system chaos will occur when parameter variations and external disturbances change to a certain degree.

  9. HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS.

    Science.gov (United States)

    Fan, Jianqing; Liao, Yuan; Mincheva, Martina

    2011-01-01

    The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied.

  10. High-dimensional data in economics and their (robust) analysis

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan

    2017-01-01

    Roč. 12, č. 1 (2017), s. 171-183 ISSN 1452-4864 R&D Projects: GA ČR GA17-07384S Institutional support: RVO:67985556 Keywords : econometrics * high-dimensional data * dimensionality reduction * linear regression * classification analysis * robustness Subject RIV: BA - General Mathematics OBOR OECD: Business and management http://library.utia.cas.cz/separaty/2017/SI/kalina-0474076.pdf

  11. High-dimensional Data in Economics and their (Robust) Analysis

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan

    2017-01-01

    Roč. 12, č. 1 (2017), s. 171-183 ISSN 1452-4864 R&D Projects: GA ČR GA17-07384S Grant - others:GA ČR(CZ) GA13-01930S Institutional support: RVO:67985807 Keywords : econometrics * high-dimensional data * dimensionality reduction * linear regression * classification analysis * robustness Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Statistics and probability

  12. Quantifying high dimensional entanglement with two mutually unbiased bases

    Directory of Open Access Journals (Sweden)

    Paul Erker

    2017-07-01

    Full Text Available We derive a framework for quantifying entanglement in multipartite and high dimensional systems using only correlations in two unbiased bases. We furthermore develop such bounds in cases where the second basis is not characterized beyond being unbiased, thus enabling entanglement quantification with minimal assumptions. Furthermore, we show that it is feasible to experimentally implement our method with readily available equipment and even conservative estimates of physical parameters.

  13. Covariance Method of the Tunneling Radiation from High Dimensional Rotating Black Holes

    Science.gov (United States)

    Li, Hui-Ling; Han, Yi-Wen; Chen, Shuai-Ru; Ding, Cong

    2018-04-01

    In this paper, Angheben-Nadalini-Vanzo-Zerbini (ANVZ) covariance method is used to study the tunneling radiation from the Kerr-Gödel black hole and Myers-Perry black hole with two independent angular momentum. By solving the Hamilton-Jacobi equation and separating the variables, the radial motion equation of a tunneling particle is obtained. Using near horizon approximation and the distance of the proper pure space, we calculate the tunneling rate and the temperature of Hawking radiation. Thus, the method of ANVZ covariance is extended to the research of high dimensional black hole tunneling radiation.

  14. High-dimensional quantum key distribution based on multicore fiber using silicon photonic integrated circuits

    DEFF Research Database (Denmark)

    Ding, Yunhong; Bacco, Davide; Dalgaard, Kjeld

    2017-01-01

    is intrinsically limited to 1 bit/photon. Here we propose and experimentally demonstrate, for the first time, a high-dimensional quantum key distribution protocol based on space division multiplexing in multicore fiber using silicon photonic integrated lightwave circuits. We successfully realized three mutually......-dimensional quantum states, and enables breaking the information efficiency limit of traditional quantum key distribution protocols. In addition, the silicon photonic circuits used in our work integrate variable optical attenuators, highly efficient multicore fiber couplers, and Mach-Zehnder interferometers, enabling...

  15. Inferring biological tasks using Pareto analysis of high-dimensional data.

    Science.gov (United States)

    Hart, Yuval; Sheftel, Hila; Hausser, Jean; Szekely, Pablo; Ben-Moshe, Noa Bossel; Korem, Yael; Tendler, Avichai; Mayo, Avraham E; Alon, Uri

    2015-03-01

    We present the Pareto task inference method (ParTI; http://www.weizmann.ac.il/mcb/UriAlon/download/ParTI) for inferring biological tasks from high-dimensional biological data. Data are described as a polytope, and features maximally enriched closest to the vertices (or archetypes) allow identification of the tasks the vertices represent. We demonstrate that human breast tumors and mouse tissues are well described by tetrahedrons in gene expression space, with specific tumor types and biological functions enriched at each of the vertices, suggesting four key tasks.

  16. Hawking radiation of a high-dimensional rotating black hole

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Ren; Zhang, Lichun; Li, Huaifan; Wu, Yueqin [Shanxi Datong University, Institute of Theoretical Physics, Department of Physics, Datong (China)

    2010-01-15

    We extend the classical Damour-Ruffini method and discuss Hawking radiation spectrum of high-dimensional rotating black hole using Tortoise coordinate transformation defined by taking the reaction of the radiation to the spacetime into consideration. Under the condition that the energy and angular momentum are conservative, taking self-gravitation action into account, we derive Hawking radiation spectrums which satisfy unitary principle in quantum mechanics. It is shown that the process that the black hole radiates particles with energy {omega} is a continuous tunneling process. We provide a theoretical basis for further studying the physical mechanism of black-hole radiation. (orig.)

  17. On spectral distribution of high dimensional covariation matrices

    DEFF Research Database (Denmark)

    Heinrich, Claudio; Podolskij, Mark

    In this paper we present the asymptotic theory for spectral distributions of high dimensional covariation matrices of Brownian diffusions. More specifically, we consider N-dimensional Itô integrals with time varying matrix-valued integrands. We observe n equidistant high frequency data points...... of the underlying Brownian diffusion and we assume that N/n -> c in (0,oo). We show that under a certain mixed spectral moment condition the spectral distribution of the empirical covariation matrix converges in distribution almost surely. Our proof relies on method of moments and applications of graph theory....

  18. High-dimensional quantum channel estimation using classical light

    CSIR Research Space (South Africa)

    Mabena, Chemist M

    2017-11-01

    Full Text Available stream_source_info Mabena_20007_2017.pdf.txt stream_content_type text/plain stream_size 960 Content-Encoding UTF-8 stream_name Mabena_20007_2017.pdf.txt Content-Type text/plain; charset=UTF-8 PHYSICAL REVIEW A 96, 053860... (2017) High-dimensional quantum channel estimation using classical light Chemist M. Mabena CSIR National Laser Centre, P.O. Box 395, Pretoria 0001, South Africa and School of Physics, University of the Witwatersrand, Johannesburg 2000, South...

  19. Ghosts in high dimensional non-linear dynamical systems: The example of the hypercycle

    International Nuclear Information System (INIS)

    Sardanyes, Josep

    2009-01-01

    Ghost-induced delayed transitions are analyzed in high dimensional non-linear dynamical systems by means of the hypercycle model. The hypercycle is a network of catalytically-coupled self-replicating RNA-like macromolecules, and has been suggested to be involved in the transition from non-living to living matter in the context of earlier prebiotic evolution. It is demonstrated that, in the vicinity of the saddle-node bifurcation for symmetric hypercycles, the persistence time before extinction, T ε , tends to infinity as n→∞ (being n the number of units of the hypercycle), thus suggesting that the increase in the number of hypercycle units involves a longer resilient time before extinction because of the ghost. Furthermore, by means of numerical analysis the dynamics of three large hypercycle networks is also studied, focusing in their extinction dynamics associated to the ghosts. Such networks allow to explore the properties of the ghosts living in high dimensional phase space with n = 5, n = 10 and n = 15 dimensions. These hypercyclic networks, in agreement with other works, are shown to exhibit self-maintained oscillations governed by stable limit cycles. The bifurcation scenarios for these hypercycles are analyzed, as well as the effect of the phase space dimensionality in the delayed transition phenomena and in the scaling properties of the ghosts near bifurcation threshold

  20. Reducing the Complexity of Genetic Fuzzy Classifiers in Highly-Dimensional Classification Problems

    Directory of Open Access Journals (Sweden)

    DimitrisG. Stavrakoudis

    2012-04-01

    Full Text Available This paper introduces the Fast Iterative Rule-based Linguistic Classifier (FaIRLiC, a Genetic Fuzzy Rule-Based Classification System (GFRBCS which targets at reducing the structural complexity of the resulting rule base, as well as its learning algorithm's computational requirements, especially when dealing with high-dimensional feature spaces. The proposed methodology follows the principles of the iterative rule learning (IRL approach, whereby a rule extraction algorithm (REA is invoked in an iterative fashion, producing one fuzzy rule at a time. The REA is performed in two successive steps: the first one selects the relevant features of the currently extracted rule, whereas the second one decides the antecedent part of the fuzzy rule, using the previously selected subset of features. The performance of the classifier is finally optimized through a genetic tuning post-processing stage. Comparative results in a hyperspectral remote sensing classification as well as in 12 real-world classification datasets indicate the effectiveness of the proposed methodology in generating high-performing and compact fuzzy rule-based classifiers, even for very high-dimensional feature spaces.

  1. Scalable Nearest Neighbor Algorithms for High Dimensional Data.

    Science.gov (United States)

    Muja, Marius; Lowe, David G

    2014-11-01

    For many computer vision and machine learning problems, large training sets are key for good performance. However, the most computationally expensive part of many computer vision and machine learning algorithms consists of finding nearest neighbor matches to high dimensional vectors that represent the training data. We propose new algorithms for approximate nearest neighbor matching and evaluate and compare them with previous algorithms. For matching high dimensional features, we find two algorithms to be the most efficient: the randomized k-d forest and a new algorithm proposed in this paper, the priority search k-means tree. We also propose a new algorithm for matching binary features by searching multiple hierarchical clustering trees and show it outperforms methods typically used in the literature. We show that the optimal nearest neighbor algorithm and its parameters depend on the data set characteristics and describe an automated configuration procedure for finding the best algorithm to search a particular data set. In order to scale to very large data sets that would otherwise not fit in the memory of a single machine, we propose a distributed nearest neighbor matching framework that can be used with any of the algorithms described in the paper. All this research has been released as an open source library called fast library for approximate nearest neighbors (FLANN), which has been incorporated into OpenCV and is now one of the most popular libraries for nearest neighbor matching.

  2. High-Dimensional Adaptive Particle Swarm Optimization on Heterogeneous Systems

    International Nuclear Information System (INIS)

    Wachowiak, M P; Sarlo, B B; Foster, A E Lambe

    2014-01-01

    Much work has recently been reported in parallel GPU-based particle swarm optimization (PSO). Motivated by the encouraging results of these investigations, while also recognizing the limitations of GPU-based methods for big problems using a large amount of data, this paper explores the efficacy of employing other types of parallel hardware for PSO. Most commodity systems feature a variety of architectures whose high-performance capabilities can be exploited. In this paper, high-dimensional problems and those that employ a large amount of external data are explored within the context of heterogeneous systems. Large problems are decomposed into constituent components, and analyses are undertaken of which components would benefit from multi-core or GPU parallelism. The current study therefore provides another demonstration that ''supercomputing on a budget'' is possible when subtasks of large problems are run on hardware most suited to these tasks. Experimental results show that large speedups can be achieved on high dimensional, data-intensive problems. Cost functions must first be analysed for parallelization opportunities, and assigned hardware based on the particular task

  3. High-dimensional single-cell cancer biology.

    Science.gov (United States)

    Irish, Jonathan M; Doxie, Deon B

    2014-01-01

    Cancer cells are distinguished from each other and from healthy cells by features that drive clonal evolution and therapy resistance. New advances in high-dimensional flow cytometry make it possible to systematically measure mechanisms of tumor initiation, progression, and therapy resistance on millions of cells from human tumors. Here we describe flow cytometry techniques that enable a "single-cell " view of cancer. High-dimensional techniques like mass cytometry enable multiplexed single-cell analysis of cell identity, clinical biomarkers, signaling network phospho-proteins, transcription factors, and functional readouts of proliferation, cell cycle status, and apoptosis. This capability pairs well with a signaling profiles approach that dissects mechanism by systematically perturbing and measuring many nodes in a signaling network. Single-cell approaches enable study of cellular heterogeneity of primary tissues and turn cell subsets into experimental controls or opportunities for new discovery. Rare populations of stem cells or therapy-resistant cancer cells can be identified and compared to other types of cells within the same sample. In the long term, these techniques will enable tracking of minimal residual disease (MRD) and disease progression. By better understanding biological systems that control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells. Single-cell approaches that provide deep insight into cell signaling and fate decisions will be critical to optimizing the next generation of cancer treatments combining targeted approaches and immunotherapy.

  4. A comprehensive analysis of earthquake damage patterns using high dimensional model representation feature selection

    Science.gov (United States)

    Taşkin Kaya, Gülşen

    2013-10-01

    Recently, earthquake damage assessment using satellite images has been a very popular ongoing research direction. Especially with the availability of very high resolution (VHR) satellite images, a quite detailed damage map based on building scale has been produced, and various studies have also been conducted in the literature. As the spatial resolution of satellite images increases, distinguishability of damage patterns becomes more cruel especially in case of using only the spectral information during classification. In order to overcome this difficulty, textural information needs to be involved to the classification to improve the visual quality and reliability of damage map. There are many kinds of textural information which can be derived from VHR satellite images depending on the algorithm used. However, extraction of textural information and evaluation of them have been generally a time consuming process especially for the large areas affected from the earthquake due to the size of VHR image. Therefore, in order to provide a quick damage map, the most useful features describing damage patterns needs to be known in advance as well as the redundant features. In this study, a very high resolution satellite image after Iran, Bam earthquake was used to identify the earthquake damage. Not only the spectral information, textural information was also used during the classification. For textural information, second order Haralick features were extracted from the panchromatic image for the area of interest using gray level co-occurrence matrix with different size of windows and directions. In addition to using spatial features in classification, the most useful features representing the damage characteristic were selected with a novel feature selection method based on high dimensional model representation (HDMR) giving sensitivity of each feature during classification. The method called HDMR was recently proposed as an efficient tool to capture the input

  5. Construction of high-dimensional universal quantum logic gates using a Λ system coupled with a whispering-gallery-mode microresonator.

    Science.gov (United States)

    He, Ling Yan; Wang, Tie-Jun; Wang, Chuan

    2016-07-11

    High-dimensional quantum system provides a higher capacity of quantum channel, which exhibits potential applications in quantum information processing. However, high-dimensional universal quantum logic gates is difficult to achieve directly with only high-dimensional interaction between two quantum systems and requires a large number of two-dimensional gates to build even a small high-dimensional quantum circuits. In this paper, we propose a scheme to implement a general controlled-flip (CF) gate where the high-dimensional single photon serve as the target qudit and stationary qubits work as the control logic qudit, by employing a three-level Λ-type system coupled with a whispering-gallery-mode microresonator. In our scheme, the required number of interaction times between the photon and solid state system reduce greatly compared with the traditional method which decomposes the high-dimensional Hilbert space into 2-dimensional quantum space, and it is on a shorter temporal scale for the experimental realization. Moreover, we discuss the performance and feasibility of our hybrid CF gate, concluding that it can be easily extended to a 2n-dimensional case and it is feasible with current technology.

  6. Class prediction for high-dimensional class-imbalanced data

    Directory of Open Access Journals (Sweden)

    Lusa Lara

    2010-10-01

    Full Text Available Abstract Background The goal of class prediction studies is to develop rules to accurately predict the class membership of new samples. The rules are derived using the values of the variables available for each subject: the main characteristic of high-dimensional data is that the number of variables greatly exceeds the number of samples. Frequently the classifiers are developed using class-imbalanced data, i.e., data sets where the number of samples in each class is not equal. Standard classification methods used on class-imbalanced data often produce classifiers that do not accurately predict the minority class; the prediction is biased towards the majority class. In this paper we investigate if the high-dimensionality poses additional challenges when dealing with class-imbalanced prediction. We evaluate the performance of six types of classifiers on class-imbalanced data, using simulated data and a publicly available data set from a breast cancer gene-expression microarray study. We also investigate the effectiveness of some strategies that are available to overcome the effect of class imbalance. Results Our results show that the evaluated classifiers are highly sensitive to class imbalance and that variable selection introduces an additional bias towards classification into the majority class. Most new samples are assigned to the majority class from the training set, unless the difference between the classes is very large. As a consequence, the class-specific predictive accuracies differ considerably. When the class imbalance is not too severe, down-sizing and asymmetric bagging embedding variable selection work well, while over-sampling does not. Variable normalization can further worsen the performance of the classifiers. Conclusions Our results show that matching the prevalence of the classes in training and test set does not guarantee good performance of classifiers and that the problems related to classification with class

  7. High-dimensional change-point estimation: Combining filtering with convex optimization

    OpenAIRE

    Soh, Yong Sheng; Chandrasekaran, Venkat

    2017-01-01

    We consider change-point estimation in a sequence of high-dimensional signals given noisy observations. Classical approaches to this problem such as the filtered derivative method are useful for sequences of scalar-valued signals, but they have undesirable scaling behavior in the high-dimensional setting. However, many high-dimensional signals encountered in practice frequently possess latent low-dimensional structure. Motivated by this observation, we propose a technique for high-dimensional...

  8. Applying recursive numerical integration techniques for solving high dimensional integrals

    International Nuclear Information System (INIS)

    Ammon, Andreas; Genz, Alan; Hartung, Tobias; Jansen, Karl; Volmer, Julia; Leoevey, Hernan

    2016-11-01

    The error scaling for Markov-Chain Monte Carlo techniques (MCMC) with N samples behaves like 1/√(N). This scaling makes it often very time intensive to reduce the error of computed observables, in particular for applications in lattice QCD. It is therefore highly desirable to have alternative methods at hand which show an improved error scaling. One candidate for such an alternative integration technique is the method of recursive numerical integration (RNI). The basic idea of this method is to use an efficient low-dimensional quadrature rule (usually of Gaussian type) and apply it iteratively to integrate over high-dimensional observables and Boltzmann weights. We present the application of such an algorithm to the topological rotor and the anharmonic oscillator and compare the error scaling to MCMC results. In particular, we demonstrate that the RNI technique shows an error scaling in the number of integration points m that is at least exponential.

  9. High-dimensional cluster analysis with the Masked EM Algorithm

    Science.gov (United States)

    Kadir, Shabnam N.; Goodman, Dan F. M.; Harris, Kenneth D.

    2014-01-01

    Cluster analysis faces two problems in high dimensions: first, the “curse of dimensionality” that can lead to overfitting and poor generalization performance; and second, the sheer time taken for conventional algorithms to process large amounts of high-dimensional data. We describe a solution to these problems, designed for the application of “spike sorting” for next-generation high channel-count neural probes. In this problem, only a small subset of features provide information about the cluster member-ship of any one data vector, but this informative feature subset is not the same for all data points, rendering classical feature selection ineffective. We introduce a “Masked EM” algorithm that allows accurate and time-efficient clustering of up to millions of points in thousands of dimensions. We demonstrate its applicability to synthetic data, and to real-world high-channel-count spike sorting data. PMID:25149694

  10. Network Reconstruction From High-Dimensional Ordinary Differential Equations.

    Science.gov (United States)

    Chen, Shizhe; Shojaie, Ali; Witten, Daniela M

    2017-01-01

    We consider the task of learning a dynamical system from high-dimensional time-course data. For instance, we might wish to estimate a gene regulatory network from gene expression data measured at discrete time points. We model the dynamical system nonparametrically as a system of additive ordinary differential equations. Most existing methods for parameter estimation in ordinary differential equations estimate the derivatives from noisy observations. This is known to be challenging and inefficient. We propose a novel approach that does not involve derivative estimation. We show that the proposed method can consistently recover the true network structure even in high dimensions, and we demonstrate empirical improvement over competing approaches. Supplementary materials for this article are available online.

  11. Quantum correlation of high dimensional system in a dephasing environment

    Science.gov (United States)

    Ji, Yinghua; Ke, Qiang; Hu, Juju

    2018-05-01

    For a high dimensional spin-S system embedded in a dephasing environment, we theoretically analyze the time evolutions of quantum correlation and entanglement via Frobenius norm and negativity. The quantum correlation dynamics can be considered as a function of the decoherence parameters, including the ratio between the system oscillator frequency ω0 and the reservoir cutoff frequency ωc , and the different environment temperature. It is shown that the quantum correlation can not only measure nonclassical correlation of the considered system, but also perform a better robustness against the dissipation. In addition, the decoherence presents the non-Markovian features and the quantum correlation freeze phenomenon. The former is much weaker than that in the sub-Ohmic or Ohmic thermal reservoir environment.

  12. Applying recursive numerical integration techniques for solving high dimensional integrals

    Energy Technology Data Exchange (ETDEWEB)

    Ammon, Andreas [IVU Traffic Technologies AG, Berlin (Germany); Genz, Alan [Washington State Univ., Pullman, WA (United States). Dept. of Mathematics; Hartung, Tobias [King' s College, London (United Kingdom). Dept. of Mathematics; Jansen, Karl; Volmer, Julia [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Leoevey, Hernan [Humboldt Univ. Berlin (Germany). Inst. fuer Mathematik

    2016-11-15

    The error scaling for Markov-Chain Monte Carlo techniques (MCMC) with N samples behaves like 1/√(N). This scaling makes it often very time intensive to reduce the error of computed observables, in particular for applications in lattice QCD. It is therefore highly desirable to have alternative methods at hand which show an improved error scaling. One candidate for such an alternative integration technique is the method of recursive numerical integration (RNI). The basic idea of this method is to use an efficient low-dimensional quadrature rule (usually of Gaussian type) and apply it iteratively to integrate over high-dimensional observables and Boltzmann weights. We present the application of such an algorithm to the topological rotor and the anharmonic oscillator and compare the error scaling to MCMC results. In particular, we demonstrate that the RNI technique shows an error scaling in the number of integration points m that is at least exponential.

  13. Reduced order surrogate modelling (ROSM) of high dimensional deterministic simulations

    Science.gov (United States)

    Mitry, Mina

    Often, computationally expensive engineering simulations can prohibit the engineering design process. As a result, designers may turn to a less computationally demanding approximate, or surrogate, model to facilitate their design process. However, owing to the the curse of dimensionality, classical surrogate models become too computationally expensive for high dimensional data. To address this limitation of classical methods, we develop linear and non-linear Reduced Order Surrogate Modelling (ROSM) techniques. Two algorithms are presented, which are based on a combination of linear/kernel principal component analysis and radial basis functions. These algorithms are applied to subsonic and transonic aerodynamic data, as well as a model for a chemical spill in a channel. The results of this thesis show that ROSM can provide a significant computational benefit over classical surrogate modelling, sometimes at the expense of a minor loss in accuracy.

  14. Asymptotics of empirical eigenstructure for high dimensional spiked covariance.

    Science.gov (United States)

    Wang, Weichen; Fan, Jianqing

    2017-06-01

    We derive the asymptotic distributions of the spiked eigenvalues and eigenvectors under a generalized and unified asymptotic regime, which takes into account the magnitude of spiked eigenvalues, sample size, and dimensionality. This regime allows high dimensionality and diverging eigenvalues and provides new insights into the roles that the leading eigenvalues, sample size, and dimensionality play in principal component analysis. Our results are a natural extension of those in Paul (2007) to a more general setting and solve the rates of convergence problems in Shen et al. (2013). They also reveal the biases of estimating leading eigenvalues and eigenvectors by using principal component analysis, and lead to a new covariance estimator for the approximate factor model, called shrinkage principal orthogonal complement thresholding (S-POET), that corrects the biases. Our results are successfully applied to outstanding problems in estimation of risks of large portfolios and false discovery proportions for dependent test statistics and are illustrated by simulation studies.

  15. On the choice of the adjusting mouth electrode profile at the input of a linear accelerator with space-uniform quadrupole focusing

    International Nuclear Information System (INIS)

    Balabin, A.I.; Kapchinskij, I.M.; Lipkin, I.M.

    1983-01-01

    Beam matching of an electrostatical injector with a linear accelerator is an important problem, since acceptance at the inlet of a linac with space-homogeneous quadrupole focusing (SHQF) does not remain constant but rotates with the frequency of an accelerating field. A possibility of transverse stationary beam matching with the SHQF at the inlet of the linac can be ensured to a considerable extent by means of an initial matching section (matching mouth) at the length of which focusing hardness varies according to a certain law. In this case the purpose of creating beam matching conditions practically independent of the phases of particles at the inlet into the mouth is attained. Transverse beam matching for different laws of focusing hardness variation along the non-modulated mouth is investigated. It is shown that for earlier suggested laws of hardness variation the matching conditions at the mouth inlet are critically dependent on the input phases of particles at high phase densities of the beam current j. Laws of hardness variation ensuring actual matching condition independence of the phases of particles up to j=2 A/cmxmrad (for protons) are suggested. A case of beam matching by means of the modulated mouth is also considered. Recommendations on mouth modulation laws are given

  16. A probabilistic graphical model based stochastic input model construction

    International Nuclear Information System (INIS)

    Wan, Jiang; Zabaras, Nicholas

    2014-01-01

    Model reduction techniques have been widely used in modeling of high-dimensional stochastic input in uncertainty quantification tasks. However, the probabilistic modeling of random variables projected into reduced-order spaces presents a number of computational challenges. Due to the curse of dimensionality, the underlying dependence relationships between these random variables are difficult to capture. In this work, a probabilistic graphical model based approach is employed to learn the dependence by running a number of conditional independence tests using observation data. Thus a probabilistic model of the joint PDF is obtained and the PDF is factorized into a set of conditional distributions based on the dependence structure of the variables. The estimation of the joint PDF from data is then transformed to estimating conditional distributions under reduced dimensions. To improve the computational efficiency, a polynomial chaos expansion is further applied to represent the random field in terms of a set of standard random variables. This technique is combined with both linear and nonlinear model reduction methods. Numerical examples are presented to demonstrate the accuracy and efficiency of the probabilistic graphical model based stochastic input models. - Highlights: • Data-driven stochastic input models without the assumption of independence of the reduced random variables. • The problem is transformed to a Bayesian network structure learning problem. • Examples are given in flows in random media

  17. An adaptive ANOVA-based PCKF for high-dimensional nonlinear inverse modeling

    Science.gov (United States)

    Li, Weixuan; Lin, Guang; Zhang, Dongxiao

    2014-02-01

    The probabilistic collocation-based Kalman filter (PCKF) is a recently developed approach for solving inverse problems. It resembles the ensemble Kalman filter (EnKF) in every aspect-except that it represents and propagates model uncertainty by polynomial chaos expansion (PCE) instead of an ensemble of model realizations. Previous studies have shown PCKF is a more efficient alternative to EnKF for many data assimilation problems. However, the accuracy and efficiency of PCKF depends on an appropriate truncation of the PCE series. Having more polynomial chaos basis functions in the expansion helps to capture uncertainty more accurately but increases computational cost. Selection of basis functions is particularly important for high-dimensional stochastic problems because the number of polynomial chaos basis functions required to represent model uncertainty grows dramatically as the number of input parameters (random dimensions) increases. In classic PCKF algorithms, the PCE basis functions are pre-set based on users' experience. Also, for sequential data assimilation problems, the basis functions kept in PCE expression remain unchanged in different Kalman filter loops, which could limit the accuracy and computational efficiency of classic PCKF algorithms. To address this issue, we present a new algorithm that adaptively selects PCE basis functions for different problems and automatically adjusts the number of basis functions in different Kalman filter loops. The algorithm is based on adaptive functional ANOVA (analysis of variance) decomposition, which approximates a high-dimensional function with the summation of a set of low-dimensional functions. Thus, instead of expanding the original model into PCE, we implement the PCE expansion on these low-dimensional functions, which is much less costly. We also propose a new adaptive criterion for ANOVA that is more suited for solving inverse problems. The new algorithm was tested with different examples and demonstrated

  18. Gene masking - a technique to improve accuracy for cancer classification with high dimensionality in microarray data.

    Science.gov (United States)

    Saini, Harsh; Lal, Sunil Pranit; Naidu, Vimal Vikash; Pickering, Vincel Wince; Singh, Gurmeet; Tsunoda, Tatsuhiko; Sharma, Alok

    2016-12-05

    High dimensional feature space generally degrades classification in several applications. In this paper, we propose a strategy called gene masking, in which non-contributing dimensions are heuristically removed from the data to improve classification accuracy. Gene masking is implemented via a binary encoded genetic algorithm that can be integrated seamlessly with classifiers during the training phase of classification to perform feature selection. It can also be used to discriminate between features that contribute most to the classification, thereby, allowing researchers to isolate features that may have special significance. This technique was applied on publicly available datasets whereby it substantially reduced the number of features used for classification while maintaining high accuracies. The proposed technique can be extremely useful in feature selection as it heuristically removes non-contributing features to improve the performance of classifiers.

  19. High-dimensional atom localization via spontaneously generated coherence in a microwave-driven atomic system.

    Science.gov (United States)

    Wang, Zhiping; Chen, Jinyu; Yu, Benli

    2017-02-20

    We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to the space-dependent atom-field interaction, it is found that the detecting probability and precision of 2D and 3D atom localization behaviors can be significantly improved via adjusting the system parameters, the phase, amplitude, and initial population distribution. Interestingly, the atom can be localized in volumes that are substantially smaller than a cubic optical wavelength. Our scheme opens a promising way to achieve high-precision and high-efficiency atom localization, which provides some potential applications in high-dimensional atom nanolithography.

  20. A sparse grid based method for generative dimensionality reduction of high-dimensional data

    Science.gov (United States)

    Bohn, Bastian; Garcke, Jochen; Griebel, Michael

    2016-03-01

    Generative dimensionality reduction methods play an important role in machine learning applications because they construct an explicit mapping from a low-dimensional space to the high-dimensional data space. We discuss a general framework to describe generative dimensionality reduction methods, where the main focus lies on a regularized principal manifold learning variant. Since most generative dimensionality reduction algorithms exploit the representer theorem for reproducing kernel Hilbert spaces, their computational costs grow at least quadratically in the number n of data. Instead, we introduce a grid-based discretization approach which automatically scales just linearly in n. To circumvent the curse of dimensionality of full tensor product grids, we use the concept of sparse grids. Furthermore, in real-world applications, some embedding directions are usually more important than others and it is reasonable to refine the underlying discretization space only in these directions. To this end, we employ a dimension-adaptive algorithm which is based on the ANOVA (analysis of variance) decomposition of a function. In particular, the reconstruction error is used to measure the quality of an embedding. As an application, the study of large simulation data from an engineering application in the automotive industry (car crash simulation) is performed.

  1. Progress in high-dimensional percolation and random graphs

    CERN Document Server

    Heydenreich, Markus

    2017-01-01

    This text presents an engaging exposition of the active field of high-dimensional percolation that will likely provide an impetus for future work. With over 90 exercises designed to enhance the reader’s understanding of the material, as well as many open problems, the book is aimed at graduate students and researchers who wish to enter the world of this rich topic.  The text may also be useful in advanced courses and seminars, as well as for reference and individual study. Part I, consisting of 3 chapters, presents a general introduction to percolation, stating the main results, defining the central objects, and proving its main properties. No prior knowledge of percolation is assumed. Part II, consisting of Chapters 4–9, discusses mean-field critical behavior by describing the two main techniques used, namely, differential inequalities and the lace expansion. In Parts I and II, all results are proved, making this the first self-contained text discussing high-dimensiona l percolation.  Part III, consist...

  2. Effects of dependence in high-dimensional multiple testing problems

    Directory of Open Access Journals (Sweden)

    van de Wiel Mark A

    2008-02-01

    Full Text Available Abstract Background We consider effects of dependence among variables of high-dimensional data in multiple hypothesis testing problems, in particular the False Discovery Rate (FDR control procedures. Recent simulation studies consider only simple correlation structures among variables, which is hardly inspired by real data features. Our aim is to systematically study effects of several network features like sparsity and correlation strength by imposing dependence structures among variables using random correlation matrices. Results We study the robustness against dependence of several FDR procedures that are popular in microarray studies, such as Benjamin-Hochberg FDR, Storey's q-value, SAM and resampling based FDR procedures. False Non-discovery Rates and estimates of the number of null hypotheses are computed from those methods and compared. Our simulation study shows that methods such as SAM and the q-value do not adequately control the FDR to the level claimed under dependence conditions. On the other hand, the adaptive Benjamini-Hochberg procedure seems to be most robust while remaining conservative. Finally, the estimates of the number of true null hypotheses under various dependence conditions are variable. Conclusion We discuss a new method for efficient guided simulation of dependent data, which satisfy imposed network constraints as conditional independence structures. Our simulation set-up allows for a structural study of the effect of dependencies on multiple testing criterions and is useful for testing a potentially new method on π0 or FDR estimation in a dependency context.

  3. High-dimensional quantum cryptography with twisted light

    International Nuclear Information System (INIS)

    Mirhosseini, Mohammad; Magaña-Loaiza, Omar S; O’Sullivan, Malcolm N; Rodenburg, Brandon; Malik, Mehul; Boyd, Robert W; Lavery, Martin P J; Padgett, Miles J; Gauthier, Daniel J

    2015-01-01

    Quantum key distribution (QKD) systems often rely on polarization of light for encoding, thus limiting the amount of information that can be sent per photon and placing tight bounds on the error rates that such a system can tolerate. Here we describe a proof-of-principle experiment that indicates the feasibility of high-dimensional QKD based on the transverse structure of the light field allowing for the transfer of more than 1 bit per photon. Our implementation uses the orbital angular momentum (OAM) of photons and the corresponding mutually unbiased basis of angular position (ANG). Our experiment uses a digital micro-mirror device for the rapid generation of OAM and ANG modes at 4 kHz, and a mode sorter capable of sorting single photons based on their OAM and ANG content with a separation efficiency of 93%. Through the use of a seven-dimensional alphabet encoded in the OAM and ANG bases, we achieve a channel capacity of 2.05 bits per sifted photon. Our experiment demonstrates that, in addition to having an increased information capacity, multilevel QKD systems based on spatial-mode encoding can be more resilient against intercept-resend eavesdropping attacks. (paper)

  4. Inference for High-dimensional Differential Correlation Matrices.

    Science.gov (United States)

    Cai, T Tony; Zhang, Anru

    2016-01-01

    Motivated by differential co-expression analysis in genomics, we consider in this paper estimation and testing of high-dimensional differential correlation matrices. An adaptive thresholding procedure is introduced and theoretical guarantees are given. Minimax rate of convergence is established and the proposed estimator is shown to be adaptively rate-optimal over collections of paired correlation matrices with approximately sparse differences. Simulation results show that the procedure significantly outperforms two other natural methods that are based on separate estimation of the individual correlation matrices. The procedure is also illustrated through an analysis of a breast cancer dataset, which provides evidence at the gene co-expression level that several genes, of which a subset has been previously verified, are associated with the breast cancer. Hypothesis testing on the differential correlation matrices is also considered. A test, which is particularly well suited for testing against sparse alternatives, is introduced. In addition, other related problems, including estimation of a single sparse correlation matrix, estimation of the differential covariance matrices, and estimation of the differential cross-correlation matrices, are also discussed.

  5. Efficient Smoothed Concomitant Lasso Estimation for High Dimensional Regression

    Science.gov (United States)

    Ndiaye, Eugene; Fercoq, Olivier; Gramfort, Alexandre; Leclère, Vincent; Salmon, Joseph

    2017-10-01

    In high dimensional settings, sparse structures are crucial for efficiency, both in term of memory, computation and performance. It is customary to consider ℓ 1 penalty to enforce sparsity in such scenarios. Sparsity enforcing methods, the Lasso being a canonical example, are popular candidates to address high dimension. For efficiency, they rely on tuning a parameter trading data fitting versus sparsity. For the Lasso theory to hold this tuning parameter should be proportional to the noise level, yet the latter is often unknown in practice. A possible remedy is to jointly optimize over the regression parameter as well as over the noise level. This has been considered under several names in the literature: Scaled-Lasso, Square-root Lasso, Concomitant Lasso estimation for instance, and could be of interest for uncertainty quantification. In this work, after illustrating numerical difficulties for the Concomitant Lasso formulation, we propose a modification we coined Smoothed Concomitant Lasso, aimed at increasing numerical stability. We propose an efficient and accurate solver leading to a computational cost no more expensive than the one for the Lasso. We leverage on standard ingredients behind the success of fast Lasso solvers: a coordinate descent algorithm, combined with safe screening rules to achieve speed efficiency, by eliminating early irrelevant features.

  6. Bayesian Subset Modeling for High-Dimensional Generalized Linear Models

    KAUST Repository

    Liang, Faming

    2013-06-01

    This article presents a new prior setting for high-dimensional generalized linear models, which leads to a Bayesian subset regression (BSR) with the maximum a posteriori model approximately equivalent to the minimum extended Bayesian information criterion model. The consistency of the resulting posterior is established under mild conditions. Further, a variable screening procedure is proposed based on the marginal inclusion probability, which shares the same properties of sure screening and consistency with the existing sure independence screening (SIS) and iterative sure independence screening (ISIS) procedures. However, since the proposed procedure makes use of joint information from all predictors, it generally outperforms SIS and ISIS in real applications. This article also makes extensive comparisons of BSR with the popular penalized likelihood methods, including Lasso, elastic net, SIS, and ISIS. The numerical results indicate that BSR can generally outperform the penalized likelihood methods. The models selected by BSR tend to be sparser and, more importantly, of higher prediction ability. In addition, the performance of the penalized likelihood methods tends to deteriorate as the number of predictors increases, while this is not significant for BSR. Supplementary materials for this article are available online. © 2013 American Statistical Association.

  7. Data-driven forecasting of high-dimensional chaotic systems with long short-term memory networks.

    Science.gov (United States)

    Vlachas, Pantelis R; Byeon, Wonmin; Wan, Zhong Y; Sapsis, Themistoklis P; Koumoutsakos, Petros

    2018-05-01

    We introduce a data-driven forecasting method for high-dimensional chaotic systems using long short-term memory (LSTM) recurrent neural networks. The proposed LSTM neural networks perform inference of high-dimensional dynamical systems in their reduced order space and are shown to be an effective set of nonlinear approximators of their attractor. We demonstrate the forecasting performance of the LSTM and compare it with Gaussian processes (GPs) in time series obtained from the Lorenz 96 system, the Kuramoto-Sivashinsky equation and a prototype climate model. The LSTM networks outperform the GPs in short-term forecasting accuracy in all applications considered. A hybrid architecture, extending the LSTM with a mean stochastic model (MSM-LSTM), is proposed to ensure convergence to the invariant measure. This novel hybrid method is fully data-driven and extends the forecasting capabilities of LSTM networks.

  8. Evaluation of a new high-dimensional miRNA profiling platform

    Directory of Open Access Journals (Sweden)

    Lamblin Anne-Francoise

    2009-08-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are a class of approximately 22 nucleotide long, widely expressed RNA molecules that play important regulatory roles in eukaryotes. To investigate miRNA function, it is essential that methods to quantify their expression levels be available. Methods We evaluated a new miRNA profiling platform that utilizes Illumina's existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amounts of input RNA. The beta test version was comprised of 735 miRNA targets of Illumina's miRNA profiling application. Results Reproducibility between sample replicates within a plate was good (Spearman's correlation 0.91 to 0.98 as was the plate-to-plate reproducibility replicates run on different days (Spearman's correlation 0.84 to 0.98. To determine whether quality data could be obtained from a broad range of input RNA, data obtained from amounts ranging from 25 ng to 800 ng were compared to those obtained at 200 ng. No effect across the range of RNA input was observed. Conclusion These results indicate that very small amounts of starting material are sufficient to allow sensitive miRNA profiling using the Illumina miRNA high-dimensional platform. Nonlinear biases were observed between replicates, indicating the need for abundance-dependent normalization. Overall, the performance characteristics of the Illumina miRNA profiling system were excellent.

  9. High-dimensional statistical inference: From vector to matrix

    Science.gov (United States)

    Zhang, Anru

    Statistical inference for sparse signals or low-rank matrices in high-dimensional settings is of significant interest in a range of contemporary applications. It has attracted significant recent attention in many fields including statistics, applied mathematics and electrical engineering. In this thesis, we consider several problems in including sparse signal recovery (compressed sensing under restricted isometry) and low-rank matrix recovery (matrix recovery via rank-one projections and structured matrix completion). The first part of the thesis discusses compressed sensing and affine rank minimization in both noiseless and noisy cases and establishes sharp restricted isometry conditions for sparse signal and low-rank matrix recovery. The analysis relies on a key technical tool which represents points in a polytope by convex combinations of sparse vectors. The technique is elementary while leads to sharp results. It is shown that, in compressed sensing, delta kA 0, delta kA < 1/3 + epsilon, deltak A + thetak,kA < 1 + epsilon, or deltatkA< √(t - 1) / t + epsilon are not sufficient to guarantee the exact recovery of all k-sparse signals for large k. Similar result also holds for matrix recovery. In addition, the conditions delta kA<1/3, deltak A+ thetak,kA<1, delta tkA < √(t - 1)/t and deltarM<1/3, delta rM+ thetar,rM<1, delta trM< √(t - 1)/ t are also shown to be sufficient respectively for stable recovery of approximately sparse signals and low-rank matrices in the noisy case. For the second part of the thesis, we introduce a rank-one projection model for low-rank matrix recovery and propose a constrained nuclear norm minimization method for stable recovery of low-rank matrices in the noisy case. The procedure is adaptive to the rank and robust against small perturbations. Both upper and lower bounds for the estimation accuracy under the Frobenius norm loss are obtained. The proposed estimator is shown to be rate-optimal under certain conditions. The

  10. Genuinely high-dimensional nonlocality optimized by complementary measurements

    International Nuclear Information System (INIS)

    Lim, James; Ryu, Junghee; Yoo, Seokwon; Lee, Changhyoup; Bang, Jeongho; Lee, Jinhyoung

    2010-01-01

    Qubits exhibit extreme nonlocality when their state is maximally entangled and this is observed by mutually unbiased local measurements. This criterion does not hold for the Bell inequalities of high-dimensional systems (qudits), recently proposed by Collins-Gisin-Linden-Massar-Popescu and Son-Lee-Kim. Taking an alternative approach, called the quantum-to-classical approach, we derive a series of Bell inequalities for qudits that satisfy the criterion as for the qubits. In the derivation each d-dimensional subsystem is assumed to be measured by one of d possible measurements with d being a prime integer. By applying to two qubits (d=2), we find that a derived inequality is reduced to the Clauser-Horne-Shimony-Holt inequality when the degree of nonlocality is optimized over all the possible states and local observables. Further applying to two and three qutrits (d=3), we find Bell inequalities that are violated for the three-dimensionally entangled states but are not violated by any two-dimensionally entangled states. In other words, the inequalities discriminate three-dimensional (3D) entanglement from two-dimensional (2D) entanglement and in this sense they are genuinely 3D. In addition, for the two qutrits we give a quantitative description of the relations among the three degrees of complementarity, entanglement and nonlocality. It is shown that the degree of complementarity jumps abruptly to very close to its maximum as nonlocality starts appearing. These characteristics imply that complementarity plays a more significant role in the present inequality compared with the previously proposed inequality.

  11. Approximation of High-Dimensional Rank One Tensors

    KAUST Repository

    Bachmayr, Markus

    2013-11-12

    Many real world problems are high-dimensional in that their solution is a function which depends on many variables or parameters. This presents a computational challenge since traditional numerical techniques are built on model classes for functions based solely on smoothness. It is known that the approximation of smoothness classes of functions suffers from the so-called \\'curse of dimensionality\\'. Avoiding this curse requires new model classes for real world functions that match applications. This has led to the introduction of notions such as sparsity, variable reduction, and reduced modeling. One theme that is particularly common is to assume a tensor structure for the target function. This paper investigates how well a rank one function f(x 1,...,x d)=f 1(x 1)⋯f d(x d), defined on Ω=[0,1]d can be captured through point queries. It is shown that such a rank one function with component functions f j in W∞ r([0,1]) can be captured (in L ∞) to accuracy O(C(d,r)N -r) from N well-chosen point evaluations. The constant C(d,r) scales like d dr. The queries in our algorithms have two ingredients, a set of points built on the results from discrepancy theory and a second adaptive set of queries dependent on the information drawn from the first set. Under the assumption that a point z∈Ω with nonvanishing f(z) is known, the accuracy improves to O(dN -r). © 2013 Springer Science+Business Media New York.

  12. Statistical mechanics of complex neural systems and high dimensional data

    International Nuclear Information System (INIS)

    Advani, Madhu; Lahiri, Subhaneil; Ganguli, Surya

    2013-01-01

    Recent experimental advances in neuroscience have opened new vistas into the immense complexity of neuronal networks. This proliferation of data challenges us on two parallel fronts. First, how can we form adequate theoretical frameworks for understanding how dynamical network processes cooperate across widely disparate spatiotemporal scales to solve important computational problems? Second, how can we extract meaningful models of neuronal systems from high dimensional datasets? To aid in these challenges, we give a pedagogical review of a collection of ideas and theoretical methods arising at the intersection of statistical physics, computer science and neurobiology. We introduce the interrelated replica and cavity methods, which originated in statistical physics as powerful ways to quantitatively analyze large highly heterogeneous systems of many interacting degrees of freedom. We also introduce the closely related notion of message passing in graphical models, which originated in computer science as a distributed algorithm capable of solving large inference and optimization problems involving many coupled variables. We then show how both the statistical physics and computer science perspectives can be applied in a wide diversity of contexts to problems arising in theoretical neuroscience and data analysis. Along the way we discuss spin glasses, learning theory, illusions of structure in noise, random matrices, dimensionality reduction and compressed sensing, all within the unified formalism of the replica method. Moreover, we review recent conceptual connections between message passing in graphical models, and neural computation and learning. Overall, these ideas illustrate how statistical physics and computer science might provide a lens through which we can uncover emergent computational functions buried deep within the dynamical complexities of neuronal networks. (paper)

  13. Approximation of High-Dimensional Rank One Tensors

    KAUST Repository

    Bachmayr, Markus; Dahmen, Wolfgang; DeVore, Ronald; Grasedyck, Lars

    2013-01-01

    Many real world problems are high-dimensional in that their solution is a function which depends on many variables or parameters. This presents a computational challenge since traditional numerical techniques are built on model classes for functions based solely on smoothness. It is known that the approximation of smoothness classes of functions suffers from the so-called 'curse of dimensionality'. Avoiding this curse requires new model classes for real world functions that match applications. This has led to the introduction of notions such as sparsity, variable reduction, and reduced modeling. One theme that is particularly common is to assume a tensor structure for the target function. This paper investigates how well a rank one function f(x 1,...,x d)=f 1(x 1)⋯f d(x d), defined on Ω=[0,1]d can be captured through point queries. It is shown that such a rank one function with component functions f j in W∞ r([0,1]) can be captured (in L ∞) to accuracy O(C(d,r)N -r) from N well-chosen point evaluations. The constant C(d,r) scales like d dr. The queries in our algorithms have two ingredients, a set of points built on the results from discrepancy theory and a second adaptive set of queries dependent on the information drawn from the first set. Under the assumption that a point z∈Ω with nonvanishing f(z) is known, the accuracy improves to O(dN -r). © 2013 Springer Science+Business Media New York.

  14. Joint High-Dimensional Bayesian Variable and Covariance Selection with an Application to eQTL Analysis

    KAUST Repository

    Bhadra, Anindya

    2013-04-22

    We describe a Bayesian technique to (a) perform a sparse joint selection of significant predictor variables and significant inverse covariance matrix elements of the response variables in a high-dimensional linear Gaussian sparse seemingly unrelated regression (SSUR) setting and (b) perform an association analysis between the high-dimensional sets of predictors and responses in such a setting. To search the high-dimensional model space, where both the number of predictors and the number of possibly correlated responses can be larger than the sample size, we demonstrate that a marginalization-based collapsed Gibbs sampler, in combination with spike and slab type of priors, offers a computationally feasible and efficient solution. As an example, we apply our method to an expression quantitative trait loci (eQTL) analysis on publicly available single nucleotide polymorphism (SNP) and gene expression data for humans where the primary interest lies in finding the significant associations between the sets of SNPs and possibly correlated genetic transcripts. Our method also allows for inference on the sparse interaction network of the transcripts (response variables) after accounting for the effect of the SNPs (predictor variables). We exploit properties of Gaussian graphical models to make statements concerning conditional independence of the responses. Our method compares favorably to existing Bayesian approaches developed for this purpose. © 2013, The International Biometric Society.

  15. Exploration of High-Dimensional Scalar Function for Nuclear Reactor Safety Analysis and Visualization

    Energy Technology Data Exchange (ETDEWEB)

    Dan Maljovec; Bei Wang; Valerio Pascucci; Peer-Timo Bremer; Michael Pernice; Robert Nourgaliev

    2013-05-01

    The next generation of methodologies for nuclear reactor Probabilistic Risk Assessment (PRA) explicitly accounts for the time element in modeling the probabilistic system evolution and uses numerical simulation tools to account for possible dependencies between failure events. The Monte-Carlo (MC) and the Dynamic Event Tree (DET) approaches belong to this new class of dynamic PRA methodologies. A challenge of dynamic PRA algorithms is the large amount of data they produce which may be difficult to visualize and analyze in order to extract useful information. We present a software tool that is designed to address these goals. We model a large-scale nuclear simulation dataset as a high-dimensional scalar function defined over a discrete sample of the domain. First, we provide structural analysis of such a function at multiple scales and provide insight into the relationship between the input parameters and the output. Second, we enable exploratory analysis for users, where we help the users to differentiate features from noise through multi-scale analysis on an interactive platform, based on domain knowledge and data characterization. Our analysis is performed by exploiting the topological and geometric properties of the domain, building statistical models based on its topological segmentations and providing interactive visual interfaces to facilitate such explorations. We provide a user’s guide to our software tool by highlighting its analysis and visualization capabilities, along with a use case involving dataset from a nuclear reactor safety simulation.

  16. Feature Augmentation via Nonparametrics and Selection (FANS) in High-Dimensional Classification.

    Science.gov (United States)

    Fan, Jianqing; Feng, Yang; Jiang, Jiancheng; Tong, Xin

    We propose a high dimensional classification method that involves nonparametric feature augmentation. Knowing that marginal density ratios are the most powerful univariate classifiers, we use the ratio estimates to transform the original feature measurements. Subsequently, penalized logistic regression is invoked, taking as input the newly transformed or augmented features. This procedure trains models equipped with local complexity and global simplicity, thereby avoiding the curse of dimensionality while creating a flexible nonlinear decision boundary. The resulting method is called Feature Augmentation via Nonparametrics and Selection (FANS). We motivate FANS by generalizing the Naive Bayes model, writing the log ratio of joint densities as a linear combination of those of marginal densities. It is related to generalized additive models, but has better interpretability and computability. Risk bounds are developed for FANS. In numerical analysis, FANS is compared with competing methods, so as to provide a guideline on its best application domain. Real data analysis demonstrates that FANS performs very competitively on benchmark email spam and gene expression data sets. Moreover, FANS is implemented by an extremely fast algorithm through parallel computing.

  17. Matrix correlations for high-dimensional data: The modified RV-coefficient

    NARCIS (Netherlands)

    Smilde, A.K.; Kiers, H.A.L.; Bijlsma, S.; Rubingh, C.M.; Erk, M.J. van

    2009-01-01

    Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they

  18. Robust and sparse correlation matrix estimation for the analysis of high-dimensional genomics data.

    Science.gov (United States)

    Serra, Angela; Coretto, Pietro; Fratello, Michele; Tagliaferri, Roberto; Stegle, Oliver

    2018-02-15

    Microarray technology can be used to study the expression of thousands of genes across a number of different experimental conditions, usually hundreds. The underlying principle is that genes sharing similar expression patterns, across different samples, can be part of the same co-expression system, or they may share the same biological functions. Groups of genes are usually identified based on cluster analysis. Clustering methods rely on the similarity matrix between genes. A common choice to measure similarity is to compute the sample correlation matrix. Dimensionality reduction is another popular data analysis task which is also based on covariance/correlation matrix estimates. Unfortunately, covariance/correlation matrix estimation suffers from the intrinsic noise present in high-dimensional data. Sources of noise are: sampling variations, presents of outlying sample units, and the fact that in most cases the number of units is much larger than the number of genes. In this paper, we propose a robust correlation matrix estimator that is regularized based on adaptive thresholding. The resulting method jointly tames the effects of the high-dimensionality, and data contamination. Computations are easy to implement and do not require hand tunings. Both simulated and real data are analyzed. A Monte Carlo experiment shows that the proposed method is capable of remarkable performances. Our correlation metric is more robust to outliers compared with the existing alternatives in two gene expression datasets. It is also shown how the regularization allows to automatically detect and filter spurious correlations. The same regularization is also extended to other less robust correlation measures. Finally, we apply the ARACNE algorithm on the SyNTreN gene expression data. Sensitivity and specificity of the reconstructed network is compared with the gold standard. We show that ARACNE performs better when it takes the proposed correlation matrix estimator as input. The R

  19. An Autonomous Sensor Tasking Approach for Large Scale Space Object Cataloging

    Science.gov (United States)

    Linares, R.; Furfaro, R.

    The field of Space Situational Awareness (SSA) has progressed over the last few decades with new sensors coming online, the development of new approaches for making observations, and new algorithms for processing them. Although there has been success in the development of new approaches, a missing piece is the translation of SSA goals to sensors and resource allocation; otherwise known as the Sensor Management Problem (SMP). This work solves the SMP using an artificial intelligence approach called Deep Reinforcement Learning (DRL). Stable methods for training DRL approaches based on neural networks exist, but most of these approaches are not suitable for high dimensional systems. The Asynchronous Advantage Actor-Critic (A3C) method is a recently developed and effective approach for high dimensional systems, and this work leverages these results and applies this approach to decision making in SSA. The decision space for the SSA problems can be high dimensional, even for tasking of a single telescope. Since the number of SOs in space is relatively high, each sensor will have a large number of possible actions at a given time. Therefore, efficient DRL approaches are required when solving the SMP for SSA. This work develops a A3C based method for DRL applied to SSA sensor tasking. One of the key benefits of DRL approaches is the ability to handle high dimensional data. For example DRL methods have been applied to image processing for the autonomous car application. For example, a 256x256 RGB image has 196608 parameters (256*256*3=196608) which is very high dimensional, and deep learning approaches routinely take images like this as inputs. Therefore, when applied to the whole catalog the DRL approach offers the ability to solve this high dimensional problem. This work has the potential to, for the first time, solve the non-myopic sensor tasking problem for the whole SO catalog (over 22,000 objects) providing a truly revolutionary result.

  20. Glass melting and its innovation potentials: the impact of the input and output geometries on the utilization of the melting space

    Czech Academy of Sciences Publication Activity Database

    Polák, M.; Němec, Lubomír

    2010-01-01

    Roč. 54, č. 3 (2010), s. 212-218 ISSN 0862-5468 R&D Projects: GA MPO 2A-1TP1/063 Institutional research plan: CEZ:AV0Z40320502 Keywords : space utilization, * sand dissolution * bubble removal * space geometry Subject RIV: JH - Ceramics, Fire-Resistant Materials and Glass Impact factor: 0.297, year: 2010

  1. Biomarker identification and effect estimation on schizophrenia –a high dimensional data analysis

    Directory of Open Access Journals (Sweden)

    Yuanzhang eLi

    2015-05-01

    Full Text Available Biomarkers have been examined in schizophrenia research for decades. Medical morbidity and mortality rates, as well as personal and societal costs, are associated with schizophrenia patients. The identification of biomarkers and alleles, which often have a small effect individually, may help to develop new diagnostic tests for early identification and treatment. Currently, there is not a commonly accepted statistical approach to identify predictive biomarkers from high dimensional data. We used space Decomposition-Gradient-Regression method (DGR to select biomarkers, which are associated with the risk of schizophrenia. Then, we used the gradient scores, generated from the selected biomarkers, as the prediction factor in regression to estimate their effects. We also used an alternative approach, classification and regression tree (CART, to compare the biomarker selected by DGR and found about 70% of the selected biomarkers were the same. However, the advantage of DGR is that it can evaluate individual effects for each biomarker from their combined effect. In DGR analysis of serum specimens of US military service members with a diagnosis of schizophrenia from 1992 to 2005 and their controls, Alpha-1-Antitrypsin (AAT, Interleukin-6 receptor (IL-6r and Connective Tissue Growth Factor (CTGF were selected to identify schizophrenia for males; and Alpha-1-Antitrypsin (AAT, Apolipoprotein B (Apo B and Sortilin were selected for females. If these findings from military subjects are replicated by other studies, they suggest the possibility of a novel biomarker panel as an adjunct to earlier diagnosis and initiation of treatment.

  2. Counting and classifying attractors in high dimensional dynamical systems.

    Science.gov (United States)

    Bagley, R J; Glass, L

    1996-12-07

    Randomly connected Boolean networks have been used as mathematical models of neural, genetic, and immune systems. A key quantity of such networks is the number of basins of attraction in the state space. The number of basins of attraction changes as a function of the size of the network, its connectivity and its transition rules. In discrete networks, a simple count of the number of attractors does not reveal the combinatorial structure of the attractors. These points are illustrated in a reexamination of dynamics in a class of random Boolean networks considered previously by Kauffman. We also consider comparisons between dynamics in discrete networks and continuous analogues. A continuous analogue of a discrete network may have a different number of attractors for many different reasons. Some attractors in discrete networks may be associated with unstable dynamics, and several different attractors in a discrete network may be associated with a single attractor in the continuous case. Special problems in determining attractors in continuous systems arise when there is aperiodic dynamics associated with quasiperiodicity of deterministic chaos.

  3. Mitigating the Insider Threat Using High-Dimensional Search and Modeling

    National Research Council Canada - National Science Library

    Van Den Berg, Eric; Uphadyaya, Shambhu; Ngo, Phi H; Muthukrishnan, Muthu; Palan, Rajago

    2006-01-01

    In this project a system was built aimed at mitigating insider attacks centered around a high-dimensional search engine for correlating the large number of monitoring streams necessary for detecting insider attacks...

  4. Using a High-Dimensional Graph of Semantic Space to Model Relationships among Words

    Directory of Open Access Journals (Sweden)

    Alice F Jackson

    2014-05-01

    Full Text Available The GOLD model (Graph Of Language Distribution is a network model constructed based on co-occurrence in a large corpus of natural language that may be used to explore what information may be present in a graph-structured model of language, and what information may be extracted through theoretically-driven algorithms as well as standard graph analysis methods. The present study will employ GOLD to examine two types of relationship between words: semantic similarity and associative relatedness. Semantic similarity refers to the degree of overlap in meaning between words, while associative relatedness refers to the degree to which two words occur in the same schematic context. It is expected that a graph structured model of language constructed based on co-occurrence should easily capture associative relatedness, because this type of relationship is thought to be present directly in lexical co-occurrence. However, it is hypothesized that semantic similarity may be extracted from the intersection of the set of first-order connections, because two words that are semantically similar may occupy similar thematic or syntactic roles across contexts and thus would co-occur lexically with the same set of nodes. Two versions the GOLD model that differed in terms of the co-occurence window, bigGOLD at the paragraph level and smallGOLD at the adjacent word level, were directly compared to the performance of a well-established distributional model, Latent Semantic Analysis (LSA. The superior performance of the GOLD models (big and small suggest that a single acquisition and storage mechanism, namely co-occurrence, can account for associative and conceptual relationships between words and is more psychologically plausible than models using singular value decomposition.

  5. Using a high-dimensional graph of semantic space to model relationships among words.

    Science.gov (United States)

    Jackson, Alice F; Bolger, Donald J

    2014-01-01

    The GOLD model (Graph Of Language Distribution) is a network model constructed based on co-occurrence in a large corpus of natural language that may be used to explore what information may be present in a graph-structured model of language, and what information may be extracted through theoretically-driven algorithms as well as standard graph analysis methods. The present study will employ GOLD to examine two types of relationship between words: semantic similarity and associative relatedness. Semantic similarity refers to the degree of overlap in meaning between words, while associative relatedness refers to the degree to which two words occur in the same schematic context. It is expected that a graph structured model of language constructed based on co-occurrence should easily capture associative relatedness, because this type of relationship is thought to be present directly in lexical co-occurrence. However, it is hypothesized that semantic similarity may be extracted from the intersection of the set of first-order connections, because two words that are semantically similar may occupy similar thematic or syntactic roles across contexts and thus would co-occur lexically with the same set of nodes. Two versions the GOLD model that differed in terms of the co-occurence window, bigGOLD at the paragraph level and smallGOLD at the adjacent word level, were directly compared to the performance of a well-established distributional model, Latent Semantic Analysis (LSA). The superior performance of the GOLD models (big and small) suggest that a single acquisition and storage mechanism, namely co-occurrence, can account for associative and conceptual relationships between words and is more psychologically plausible than models using singular value decomposition (SVD).

  6. An angle-based subspace anomaly detection approach to high-dimensional data: With an application to industrial fault detection

    International Nuclear Information System (INIS)

    Zhang, Liangwei; Lin, Jing; Karim, Ramin

    2015-01-01

    The accuracy of traditional anomaly detection techniques implemented on full-dimensional spaces degrades significantly as dimensionality increases, thereby hampering many real-world applications. This work proposes an approach to selecting meaningful feature subspace and conducting anomaly detection in the corresponding subspace projection. The aim is to maintain the detection accuracy in high-dimensional circumstances. The suggested approach assesses the angle between all pairs of two lines for one specific anomaly candidate: the first line is connected by the relevant data point and the center of its adjacent points; the other line is one of the axis-parallel lines. Those dimensions which have a relatively small angle with the first line are then chosen to constitute the axis-parallel subspace for the candidate. Next, a normalized Mahalanobis distance is introduced to measure the local outlier-ness of an object in the subspace projection. To comprehensively compare the proposed algorithm with several existing anomaly detection techniques, we constructed artificial datasets with various high-dimensional settings and found the algorithm displayed superior accuracy. A further experiment on an industrial dataset demonstrated the applicability of the proposed algorithm in fault detection tasks and highlighted another of its merits, namely, to provide preliminary interpretation of abnormality through feature ordering in relevant subspaces. - Highlights: • An anomaly detection approach for high-dimensional reliability data is proposed. • The approach selects relevant subspaces by assessing vectorial angles. • The novel ABSAD approach displays superior accuracy over other alternatives. • Numerical illustration approves its efficacy in fault detection applications

  7. Space-division-multiplexed transmission of 3x3 multiple-input multiple-output wireless signals over conventional graded-index multimode fiber

    NARCIS (Netherlands)

    Lei, Yi; Li, Jianqiang; Fan, Yuting; Yu, Dawei; Fu, Songnian; Yin, Feifei; Dai, Yitang; Xu, Kun

    2016-01-01

    In this paper, we experimentally demonstrate space-division-multiplexed (SDM) transmission of IEEE 802.11ac-compliant 3-spatial-stream WLAN signals over 3 spatial modes of conventional 50um graded-index (GI) multimode fiber (MMF) employing non-mode-selective 3D-waveguide photonic lantern. Two kinds

  8. A Fast Exact k-Nearest Neighbors Algorithm for High Dimensional Search Using k-Means Clustering and Triangle Inequality.

    Science.gov (United States)

    Wang, Xueyi

    2012-02-08

    The k-nearest neighbors (k-NN) algorithm is a widely used machine learning method that finds nearest neighbors of a test object in a feature space. We present a new exact k-NN algorithm called kMkNN (k-Means for k-Nearest Neighbors) that uses the k-means clustering and the triangle inequality to accelerate the searching for nearest neighbors in a high dimensional space. The kMkNN algorithm has two stages. In the buildup stage, instead of using complex tree structures such as metric trees, kd-trees, or ball-tree, kMkNN uses a simple k-means clustering method to preprocess the training dataset. In the searching stage, given a query object, kMkNN finds nearest training objects starting from the nearest cluster to the query object and uses the triangle inequality to reduce the distance calculations. Experiments show that the performance of kMkNN is surprisingly good compared to the traditional k-NN algorithm and tree-based k-NN algorithms such as kd-trees and ball-trees. On a collection of 20 datasets with up to 10(6) records and 10(4) dimensions, kMkNN shows a 2-to 80-fold reduction of distance calculations and a 2- to 60-fold speedup over the traditional k-NN algorithm for 16 datasets. Furthermore, kMkNN performs significant better than a kd-tree based k-NN algorithm for all datasets and performs better than a ball-tree based k-NN algorithm for most datasets. The results show that kMkNN is effective for searching nearest neighbors in high dimensional spaces.

  9. Engineering two-photon high-dimensional states through quantum interference

    Science.gov (United States)

    Zhang, Yingwen; Roux, Filippus S.; Konrad, Thomas; Agnew, Megan; Leach, Jonathan; Forbes, Andrew

    2016-01-01

    Many protocols in quantum science, for example, linear optical quantum computing, require access to large-scale entangled quantum states. Such systems can be realized through many-particle qubits, but this approach often suffers from scalability problems. An alternative strategy is to consider a lesser number of particles that exist in high-dimensional states. The spatial modes of light are one such candidate that provides access to high-dimensional quantum states, and thus they increase the storage and processing potential of quantum information systems. We demonstrate the controlled engineering of two-photon high-dimensional states entangled in their orbital angular momentum through Hong-Ou-Mandel interference. We prepare a large range of high-dimensional entangled states and implement precise quantum state filtering. We characterize the full quantum state before and after the filter, and are thus able to determine that only the antisymmetric component of the initial state remains. This work paves the way for high-dimensional processing and communication of multiphoton quantum states, for example, in teleportation beyond qubits. PMID:26933685

  10. A Comparison of Methods for Estimating the Determinant of High-Dimensional Covariance Matrix

    KAUST Repository

    Hu, Zongliang

    2017-09-27

    The determinant of the covariance matrix for high-dimensional data plays an important role in statistical inference and decision. It has many real applications including statistical tests and information theory. Due to the statistical and computational challenges with high dimensionality, little work has been proposed in the literature for estimating the determinant of high-dimensional covariance matrix. In this paper, we estimate the determinant of the covariance matrix using some recent proposals for estimating high-dimensional covariance matrix. Specifically, we consider a total of eight covariance matrix estimation methods for comparison. Through extensive simulation studies, we explore and summarize some interesting comparison results among all compared methods. We also provide practical guidelines based on the sample size, the dimension, and the correlation of the data set for estimating the determinant of high-dimensional covariance matrix. Finally, from a perspective of the loss function, the comparison study in this paper may also serve as a proxy to assess the performance of the covariance matrix estimation.

  11. A Comparison of Methods for Estimating the Determinant of High-Dimensional Covariance Matrix.

    Science.gov (United States)

    Hu, Zongliang; Dong, Kai; Dai, Wenlin; Tong, Tiejun

    2017-09-21

    The determinant of the covariance matrix for high-dimensional data plays an important role in statistical inference and decision. It has many real applications including statistical tests and information theory. Due to the statistical and computational challenges with high dimensionality, little work has been proposed in the literature for estimating the determinant of high-dimensional covariance matrix. In this paper, we estimate the determinant of the covariance matrix using some recent proposals for estimating high-dimensional covariance matrix. Specifically, we consider a total of eight covariance matrix estimation methods for comparison. Through extensive simulation studies, we explore and summarize some interesting comparison results among all compared methods. We also provide practical guidelines based on the sample size, the dimension, and the correlation of the data set for estimating the determinant of high-dimensional covariance matrix. Finally, from a perspective of the loss function, the comparison study in this paper may also serve as a proxy to assess the performance of the covariance matrix estimation.

  12. A Comparison of Methods for Estimating the Determinant of High-Dimensional Covariance Matrix

    KAUST Repository

    Hu, Zongliang; Dong, Kai; Dai, Wenlin; Tong, Tiejun

    2017-01-01

    The determinant of the covariance matrix for high-dimensional data plays an important role in statistical inference and decision. It has many real applications including statistical tests and information theory. Due to the statistical and computational challenges with high dimensionality, little work has been proposed in the literature for estimating the determinant of high-dimensional covariance matrix. In this paper, we estimate the determinant of the covariance matrix using some recent proposals for estimating high-dimensional covariance matrix. Specifically, we consider a total of eight covariance matrix estimation methods for comparison. Through extensive simulation studies, we explore and summarize some interesting comparison results among all compared methods. We also provide practical guidelines based on the sample size, the dimension, and the correlation of the data set for estimating the determinant of high-dimensional covariance matrix. Finally, from a perspective of the loss function, the comparison study in this paper may also serve as a proxy to assess the performance of the covariance matrix estimation.

  13. Space-division-multiplexed transmission of 3x3 multiple-input multiple-output wireless signals over conventional graded-index multimode fiber.

    Science.gov (United States)

    Lei, Yi; Li, Jianqiang; Fan, Yuting; Yu, Dawei; Fu, Songnian; Yin, Feifei; Dai, Yitang; Xu, Kun

    2016-12-12

    In this paper, we experimentally demonstrate space-division-multiplexed (SDM) transmission of IEEE 802.11ac-compliant 3-spatial-stream WLAN signals over 3 spatial modes of conventional 50um graded-index (GI) multimode fiber (MMF) employing non-mode-selective 3D-waveguide photonic lantern. Two kinds of scenarios, including fiber-only transmission and fiber-wireless hybrid transmission, were investigated by measuring error vector magnitude (EVM) performance for each stream and condition number (CN) of the channel matrix. The experimental results show that, SDM-based MMF link could offer a CNwireless MIMO signals over existing in-building commercially-available MMFs with enormous cost-saving.

  14. Linear stability theory as an early warning sign for transitions in high dimensional complex systems

    International Nuclear Information System (INIS)

    Piovani, Duccio; Grujić, Jelena; Jensen, Henrik Jeldtoft

    2016-01-01

    We analyse in detail a new approach to the monitoring and forecasting of the onset of transitions in high dimensional complex systems by application to the Tangled Nature model of evolutionary ecology and high dimensional replicator systems with a stochastic element. A high dimensional stability matrix is derived in the mean field approximation to the stochastic dynamics. This allows us to determine the stability spectrum about the observed quasi-stable configurations. From overlap of the instantaneous configuration vector of the full stochastic system with the eigenvectors of the unstable directions of the deterministic mean field approximation, we are able to construct a good early-warning indicator of the transitions occurring intermittently. (paper)

  15. Interface between path and orbital angular momentum entanglement for high-dimensional photonic quantum information.

    Science.gov (United States)

    Fickler, Robert; Lapkiewicz, Radek; Huber, Marcus; Lavery, Martin P J; Padgett, Miles J; Zeilinger, Anton

    2014-07-30

    Photonics has become a mature field of quantum information science, where integrated optical circuits offer a way to scale the complexity of the set-up as well as the dimensionality of the quantum state. On photonic chips, paths are the natural way to encode information. To distribute those high-dimensional quantum states over large distances, transverse spatial modes, like orbital angular momentum possessing Laguerre Gauss modes, are favourable as flying information carriers. Here we demonstrate a quantum interface between these two vibrant photonic fields. We create three-dimensional path entanglement between two photons in a nonlinear crystal and use a mode sorter as the quantum interface to transfer the entanglement to the orbital angular momentum degree of freedom. Thus our results show a flexible way to create high-dimensional spatial mode entanglement. Moreover, they pave the way to implement broad complex quantum networks where high-dimensionally entangled states could be distributed over distant photonic chips.

  16. Scalable Clustering of High-Dimensional Data Technique Using SPCM with Ant Colony Optimization Intelligence

    Directory of Open Access Journals (Sweden)

    Thenmozhi Srinivasan

    2015-01-01

    Full Text Available Clusters of high-dimensional data techniques are emerging, according to data noisy and poor quality challenges. This paper has been developed to cluster data using high-dimensional similarity based PCM (SPCM, with ant colony optimization intelligence which is effective in clustering nonspatial data without getting knowledge about cluster number from the user. The PCM becomes similarity based by using mountain method with it. Though this is efficient clustering, it is checked for optimization using ant colony algorithm with swarm intelligence. Thus the scalable clustering technique is obtained and the evaluation results are checked with synthetic datasets.

  17. The validation and assessment of machine learning: a game of prediction from high-dimensional data

    DEFF Research Database (Denmark)

    Pers, Tune Hannes; Albrechtsen, A; Holst, C

    2009-01-01

    In applied statistics, tools from machine learning are popular for analyzing complex and high-dimensional data. However, few theoretical results are available that could guide to the appropriate machine learning tool in a new application. Initial development of an overall strategy thus often...... the ideas, the game is applied to data from the Nugenob Study where the aim is to predict the fat oxidation capacity based on conventional factors and high-dimensional metabolomics data. Three players have chosen to use support vector machines, LASSO, and random forests, respectively....

  18. TART input manual

    International Nuclear Information System (INIS)

    Kimlinger, J.R.; Plechaty, E.F.

    1982-01-01

    The TART code is a Monte Carlo neutron/photon transport code that is only on the CRAY computer. All the input cards for the TART code are listed, and definitions for all input parameters are given. The execution and limitations of the code are described, and input for two sample problems are given

  19. An irregular grid approach for pricing high-dimensional American options

    NARCIS (Netherlands)

    Berridge, S.J.; Schumacher, J.M.

    2008-01-01

    We propose and test a new method for pricing American options in a high-dimensional setting. The method is centered around the approximation of the associated complementarity problem on an irregular grid. We approximate the partial differential operator on this grid by appealing to the SDE

  20. Reconstruction of high-dimensional states entangled in orbital angular momentum using mutually unbiased measurements

    CSIR Research Space (South Africa)

    Giovannini, D

    2013-06-01

    Full Text Available : QELS_Fundamental Science, San Jose, California United States, 9-14 June 2013 Reconstruction of High-Dimensional States Entangled in Orbital Angular Momentum Using Mutually Unbiased Measurements D. Giovannini1, ⇤, J. Romero1, 2, J. Leach3, A...

  1. Global communication schemes for the numerical solution of high-dimensional PDEs

    DEFF Research Database (Denmark)

    Hupp, Philipp; Heene, Mario; Jacob, Riko

    2016-01-01

    The numerical treatment of high-dimensional partial differential equations is among the most compute-hungry problems and in urgent need for current and future high-performance computing (HPC) systems. It is thus also facing the grand challenges of exascale computing such as the requirement...

  2. High-Dimensional Exploratory Item Factor Analysis by a Metropolis-Hastings Robbins-Monro Algorithm

    Science.gov (United States)

    Cai, Li

    2010-01-01

    A Metropolis-Hastings Robbins-Monro (MH-RM) algorithm for high-dimensional maximum marginal likelihood exploratory item factor analysis is proposed. The sequence of estimates from the MH-RM algorithm converges with probability one to the maximum likelihood solution. Details on the computer implementation of this algorithm are provided. The…

  3. Estimating the effect of a variable in a high-dimensional regression model

    DEFF Research Database (Denmark)

    Jensen, Peter Sandholt; Wurtz, Allan

    assume that the effect is identified in a high-dimensional linear model specified by unconditional moment restrictions. We consider  properties of the following methods, which rely on lowdimensional models to infer the effect: Extreme bounds analysis, the minimum t-statistic over models, Sala...

  4. Multi-Scale Factor Analysis of High-Dimensional Brain Signals

    KAUST Repository

    Ting, Chee-Ming; Ombao, Hernando; Salleh, Sh-Hussain

    2017-01-01

    In this paper, we develop an approach to modeling high-dimensional networks with a large number of nodes arranged in a hierarchical and modular structure. We propose a novel multi-scale factor analysis (MSFA) model which partitions the massive

  5. Spectrally-Corrected Estimation for High-Dimensional Markowitz Mean-Variance Optimization

    NARCIS (Netherlands)

    Z. Bai (Zhidong); H. Li (Hua); M.J. McAleer (Michael); W.-K. Wong (Wing-Keung)

    2016-01-01

    textabstractThis paper considers the portfolio problem for high dimensional data when the dimension and size are both large. We analyze the traditional Markowitz mean-variance (MV) portfolio by large dimension matrix theory, and find the spectral distribution of the sample covariance is the main

  6. Using Localised Quadratic Functions on an Irregular Grid for Pricing High-Dimensional American Options

    NARCIS (Netherlands)

    Berridge, S.J.; Schumacher, J.M.

    2004-01-01

    We propose a method for pricing high-dimensional American options on an irregular grid; the method involves using quadratic functions to approximate the local effect of the Black-Scholes operator.Once such an approximation is known, one can solve the pricing problem by time stepping in an explicit

  7. Multigrid for high dimensional elliptic partial differential equations on non-equidistant grids

    NARCIS (Netherlands)

    bin Zubair, H.; Oosterlee, C.E.; Wienands, R.

    2006-01-01

    This work presents techniques, theory and numbers for multigrid in a general d-dimensional setting. The main focus is the multigrid convergence for high-dimensional partial differential equations (PDEs). As a model problem we have chosen the anisotropic diffusion equation, on a unit hypercube. We

  8. An Irregular Grid Approach for Pricing High-Dimensional American Options

    NARCIS (Netherlands)

    Berridge, S.J.; Schumacher, J.M.

    2004-01-01

    We propose and test a new method for pricing American options in a high-dimensional setting.The method is centred around the approximation of the associated complementarity problem on an irregular grid.We approximate the partial differential operator on this grid by appealing to the SDE

  9. Pricing and hedging high-dimensional American options : an irregular grid approach

    NARCIS (Netherlands)

    Berridge, S.; Schumacher, H.

    2002-01-01

    We propose and test a new method for pricing American options in a high dimensional setting. The method is centred around the approximation of the associated variational inequality on an irregular grid. We approximate the partial differential operator on this grid by appealing to the SDE

  10. Tracking in Object Action Space

    DEFF Research Database (Denmark)

    Krüger, Volker; Herzog, Dennis

    2013-01-01

    the space of the object affordances, i.e., the space of possible actions that are applied on a given object. This way, 3D body tracking reduces to action tracking in the object (and context) primed parameter space of the object affordances. This reduces the high-dimensional joint-space to a low...

  11. Multiple Input - Multiple Output (MIMO) SAR

    Data.gov (United States)

    National Aeronautics and Space Administration — This effort will research and implement advanced Multiple-Input Multiple-Output (MIMO) Synthetic Aperture Radar (SAR) techniques which have the potential to improve...

  12. TH-CD-207A-07: Prediction of High Dimensional State Subject to Respiratory Motion: A Manifold Learning Approach

    International Nuclear Information System (INIS)

    Liu, W; Sawant, A; Ruan, D

    2016-01-01

    Purpose: The development of high dimensional imaging systems (e.g. volumetric MRI, CBCT, photogrammetry systems) in image-guided radiotherapy provides important pathways to the ultimate goal of real-time volumetric/surface motion monitoring. This study aims to develop a prediction method for the high dimensional state subject to respiratory motion. Compared to conventional linear dimension reduction based approaches, our method utilizes manifold learning to construct a descriptive feature submanifold, where more efficient and accurate prediction can be performed. Methods: We developed a prediction framework for high-dimensional state subject to respiratory motion. The proposed method performs dimension reduction in a nonlinear setting to permit more descriptive features compared to its linear counterparts (e.g., classic PCA). Specifically, a kernel PCA is used to construct a proper low-dimensional feature manifold, where low-dimensional prediction is performed. A fixed-point iterative pre-image estimation method is applied subsequently to recover the predicted value in the original state space. We evaluated and compared the proposed method with PCA-based method on 200 level-set surfaces reconstructed from surface point clouds captured by the VisionRT system. The prediction accuracy was evaluated with respect to root-mean-squared-error (RMSE) for both 200ms and 600ms lookahead lengths. Results: The proposed method outperformed PCA-based approach with statistically higher prediction accuracy. In one-dimensional feature subspace, our method achieved mean prediction accuracy of 0.86mm and 0.89mm for 200ms and 600ms lookahead lengths respectively, compared to 0.95mm and 1.04mm from PCA-based method. The paired t-tests further demonstrated the statistical significance of the superiority of our method, with p-values of 6.33e-3 and 5.78e-5, respectively. Conclusion: The proposed approach benefits from the descriptiveness of a nonlinear manifold and the prediction

  13. Input-output supervisor

    International Nuclear Information System (INIS)

    Dupuy, R.

    1970-01-01

    The input-output supervisor is the program which monitors the flow of informations between core storage and peripheral equipments of a computer. This work is composed of three parts: 1 - Study of a generalized input-output supervisor. With sample modifications it looks like most of input-output supervisors which are running now on computers. 2 - Application of this theory on a magnetic drum. 3 - Hardware requirement for time-sharing. (author) [fr

  14. Bit-Table Based Biclustering and Frequent Closed Itemset Mining in High-Dimensional Binary Data

    Directory of Open Access Journals (Sweden)

    András Király

    2014-01-01

    Full Text Available During the last decade various algorithms have been developed and proposed for discovering overlapping clusters in high-dimensional data. The two most prominent application fields in this research, proposed independently, are frequent itemset mining (developed for market basket data and biclustering (applied to gene expression data analysis. The common limitation of both methodologies is the limited applicability for very large binary data sets. In this paper we propose a novel and efficient method to find both frequent closed itemsets and biclusters in high-dimensional binary data. The method is based on simple but very powerful matrix and vector multiplication approaches that ensure that all patterns can be discovered in a fast manner. The proposed algorithm has been implemented in the commonly used MATLAB environment and freely available for researchers.

  15. Statistical Analysis for High-Dimensional Data : The Abel Symposium 2014

    CERN Document Server

    Bühlmann, Peter; Glad, Ingrid; Langaas, Mette; Richardson, Sylvia; Vannucci, Marina

    2016-01-01

    This book features research contributions from The Abel Symposium on Statistical Analysis for High Dimensional Data, held in Nyvågar, Lofoten, Norway, in May 2014. The focus of the symposium was on statistical and machine learning methodologies specifically developed for inference in “big data” situations, with particular reference to genomic applications. The contributors, who are among the most prominent researchers on the theory of statistics for high dimensional inference, present new theories and methods, as well as challenging applications and computational solutions. Specific themes include, among others, variable selection and screening, penalised regression, sparsity, thresholding, low dimensional structures, computational challenges, non-convex situations, learning graphical models, sparse covariance and precision matrices, semi- and non-parametric formulations, multiple testing, classification, factor models, clustering, and preselection. Highlighting cutting-edge research and casting light on...

  16. Single cell proteomics in biomedicine: High-dimensional data acquisition, visualization, and analysis.

    Science.gov (United States)

    Su, Yapeng; Shi, Qihui; Wei, Wei

    2017-02-01

    New insights on cellular heterogeneity in the last decade provoke the development of a variety of single cell omics tools at a lightning pace. The resultant high-dimensional single cell data generated by these tools require new theoretical approaches and analytical algorithms for effective visualization and interpretation. In this review, we briefly survey the state-of-the-art single cell proteomic tools with a particular focus on data acquisition and quantification, followed by an elaboration of a number of statistical and computational approaches developed to date for dissecting the high-dimensional single cell data. The underlying assumptions, unique features, and limitations of the analytical methods with the designated biological questions they seek to answer will be discussed. Particular attention will be given to those information theoretical approaches that are anchored in a set of first principles of physics and can yield detailed (and often surprising) predictions. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. A Shell Multi-dimensional Hierarchical Cubing Approach for High-Dimensional Cube

    Science.gov (United States)

    Zou, Shuzhi; Zhao, Li; Hu, Kongfa

    The pre-computation of data cubes is critical for improving the response time of OLAP systems and accelerating data mining tasks in large data warehouses. However, as the sizes of data warehouses grow, the time it takes to perform this pre-computation becomes a significant performance bottleneck. In a high dimensional data warehouse, it might not be practical to build all these cuboids and their indices. In this paper, we propose a shell multi-dimensional hierarchical cubing algorithm, based on an extension of the previous minimal cubing approach. This method partitions the high dimensional data cube into low multi-dimensional hierarchical cube. Experimental results show that the proposed method is significantly more efficient than other existing cubing methods.

  18. Minimax Rate-optimal Estimation of High-dimensional Covariance Matrices with Incomplete Data.

    Science.gov (United States)

    Cai, T Tony; Zhang, Anru

    2016-09-01

    Missing data occur frequently in a wide range of applications. In this paper, we consider estimation of high-dimensional covariance matrices in the presence of missing observations under a general missing completely at random model in the sense that the missingness is not dependent on the values of the data. Based on incomplete data, estimators for bandable and sparse covariance matrices are proposed and their theoretical and numerical properties are investigated. Minimax rates of convergence are established under the spectral norm loss and the proposed estimators are shown to be rate-optimal under mild regularity conditions. Simulation studies demonstrate that the estimators perform well numerically. The methods are also illustrated through an application to data from four ovarian cancer studies. The key technical tools developed in this paper are of independent interest and potentially useful for a range of related problems in high-dimensional statistical inference with missing data.

  19. Minimax Rate-optimal Estimation of High-dimensional Covariance Matrices with Incomplete Data*

    Science.gov (United States)

    Cai, T. Tony; Zhang, Anru

    2016-01-01

    Missing data occur frequently in a wide range of applications. In this paper, we consider estimation of high-dimensional covariance matrices in the presence of missing observations under a general missing completely at random model in the sense that the missingness is not dependent on the values of the data. Based on incomplete data, estimators for bandable and sparse covariance matrices are proposed and their theoretical and numerical properties are investigated. Minimax rates of convergence are established under the spectral norm loss and the proposed estimators are shown to be rate-optimal under mild regularity conditions. Simulation studies demonstrate that the estimators perform well numerically. The methods are also illustrated through an application to data from four ovarian cancer studies. The key technical tools developed in this paper are of independent interest and potentially useful for a range of related problems in high-dimensional statistical inference with missing data. PMID:27777471

  20. EPS-LASSO: Test for High-Dimensional Regression Under Extreme Phenotype Sampling of Continuous Traits.

    Science.gov (United States)

    Xu, Chao; Fang, Jian; Shen, Hui; Wang, Yu-Ping; Deng, Hong-Wen

    2018-01-25

    Extreme phenotype sampling (EPS) is a broadly-used design to identify candidate genetic factors contributing to the variation of quantitative traits. By enriching the signals in extreme phenotypic samples, EPS can boost the association power compared to random sampling. Most existing statistical methods for EPS examine the genetic factors individually, despite many quantitative traits have multiple genetic factors underlying their variation. It is desirable to model the joint effects of genetic factors, which may increase the power and identify novel quantitative trait loci under EPS. The joint analysis of genetic data in high-dimensional situations requires specialized techniques, e.g., the least absolute shrinkage and selection operator (LASSO). Although there are extensive research and application related to LASSO, the statistical inference and testing for the sparse model under EPS remain unknown. We propose a novel sparse model (EPS-LASSO) with hypothesis test for high-dimensional regression under EPS based on a decorrelated score function. The comprehensive simulation shows EPS-LASSO outperforms existing methods with stable type I error and FDR control. EPS-LASSO can provide a consistent power for both low- and high-dimensional situations compared with the other methods dealing with high-dimensional situations. The power of EPS-LASSO is close to other low-dimensional methods when the causal effect sizes are small and is superior when the effects are large. Applying EPS-LASSO to a transcriptome-wide gene expression study for obesity reveals 10 significant body mass index associated genes. Our results indicate that EPS-LASSO is an effective method for EPS data analysis, which can account for correlated predictors. The source code is available at https://github.com/xu1912/EPSLASSO. hdeng2@tulane.edu. Supplementary data are available at Bioinformatics online. © The Author (2018). Published by Oxford University Press. All rights reserved. For Permissions, please

  1. Controlling chaos in low and high dimensional systems with periodic parametric perturbations

    International Nuclear Information System (INIS)

    Mirus, K.A.; Sprott, J.C.

    1998-06-01

    The effect of applying a periodic perturbation to an accessible parameter of various chaotic systems is examined. Numerical results indicate that perturbation frequencies near the natural frequencies of the unstable periodic orbits of the chaotic systems can result in limit cycles for relatively small perturbations. Such perturbations can also control or significantly reduce the dimension of high-dimensional systems. Initial application to the control of fluctuations in a prototypical magnetic fusion plasma device will be reviewed

  2. A Comparison of Machine Learning Methods in a High-Dimensional Classification Problem

    OpenAIRE

    Zekić-Sušac, Marijana; Pfeifer, Sanja; Šarlija, Nataša

    2014-01-01

    Background: Large-dimensional data modelling often relies on variable reduction methods in the pre-processing and in the post-processing stage. However, such a reduction usually provides less information and yields a lower accuracy of the model. Objectives: The aim of this paper is to assess the high-dimensional classification problem of recognizing entrepreneurial intentions of students by machine learning methods. Methods/Approach: Four methods were tested: artificial neural networks, CART ...

  3. GAMLSS for high-dimensional data – a flexible approach based on boosting

    OpenAIRE

    Mayr, Andreas; Fenske, Nora; Hofner, Benjamin; Kneib, Thomas; Schmid, Matthias

    2010-01-01

    Generalized additive models for location, scale and shape (GAMLSS) are a popular semi-parametric modelling approach that, in contrast to conventional GAMs, regress not only the expected mean but every distribution parameter (e.g. location, scale and shape) to a set of covariates. Current fitting procedures for GAMLSS are infeasible for high-dimensional data setups and require variable selection based on (potentially problematic) information criteria. The present work describes a boosting algo...

  4. Preface [HD3-2015: International meeting on high-dimensional data-driven science

    International Nuclear Information System (INIS)

    2016-01-01

    A never-ending series of innovations in measurement technology and evolutions in information and communication technologies have led to the ongoing generation and accumulation of large quantities of high-dimensional data every day. While detailed data-centric approaches have been pursued in respective research fields, situations have been encountered where the same mathematical framework of high-dimensional data analysis can be found in a wide variety of seemingly unrelated research fields, such as estimation on the basis of undersampled Fourier transform in nuclear magnetic resonance spectroscopy in chemistry, in magnetic resonance imaging in medicine, and in astronomical interferometry in astronomy. In such situations, bringing diverse viewpoints together therefore becomes a driving force for the creation of innovative developments in various different research fields. This meeting focuses on “Sparse Modeling” (SpM) as a methodology for creation of innovative developments through the incorporation of a wide variety of viewpoints in various research fields. The objective of this meeting is to offer a forum where researchers with interest in SpM can assemble and exchange information on the latest results and newly established methodologies, and discuss future directions of the interdisciplinary studies for High-Dimensional Data-Driven science (HD 3 ). The meeting was held in Kyoto from 14-17 December 2015. We are pleased to publish 22 papers contributed by invited speakers in this volume of Journal of Physics: Conference Series. We hope that this volume will promote further development of High-Dimensional Data-Driven science. (paper)

  5. SSYST-3. Input description

    International Nuclear Information System (INIS)

    Meyder, R.

    1983-12-01

    The code system SSYST-3 is designed to analyse the thermal and mechanical behaviour of a fuel rod during a LOCA. The report contains a complete input-list for all modules and several tested inputs for a LOCA analysis. (orig.)

  6. MDS MIC Catalog Inputs

    Science.gov (United States)

    Johnson-Throop, Kathy A.; Vowell, C. W.; Smith, Byron; Darcy, Jeannette

    2006-01-01

    This viewgraph presentation reviews the inputs to the MDS Medical Information Communique (MIC) catalog. The purpose of the group is to provide input for updating the MDS MIC Catalog and to request that MMOP assign Action Item to other working groups and FSs to support the MITWG Process for developing MIC-DDs.

  7. Dissecting high-dimensional phenotypes with bayesian sparse factor analysis of genetic covariance matrices.

    Science.gov (United States)

    Runcie, Daniel E; Mukherjee, Sayan

    2013-07-01

    Quantitative genetic studies that model complex, multivariate phenotypes are important for both evolutionary prediction and artificial selection. For example, changes in gene expression can provide insight into developmental and physiological mechanisms that link genotype and phenotype. However, classical analytical techniques are poorly suited to quantitative genetic studies of gene expression where the number of traits assayed per individual can reach many thousand. Here, we derive a Bayesian genetic sparse factor model for estimating the genetic covariance matrix (G-matrix) of high-dimensional traits, such as gene expression, in a mixed-effects model. The key idea of our model is that we need consider only G-matrices that are biologically plausible. An organism's entire phenotype is the result of processes that are modular and have limited complexity. This implies that the G-matrix will be highly structured. In particular, we assume that a limited number of intermediate traits (or factors, e.g., variations in development or physiology) control the variation in the high-dimensional phenotype, and that each of these intermediate traits is sparse - affecting only a few observed traits. The advantages of this approach are twofold. First, sparse factors are interpretable and provide biological insight into mechanisms underlying the genetic architecture. Second, enforcing sparsity helps prevent sampling errors from swamping out the true signal in high-dimensional data. We demonstrate the advantages of our model on simulated data and in an analysis of a published Drosophila melanogaster gene expression data set.

  8. Hypergraph-based anomaly detection of high-dimensional co-occurrences.

    Science.gov (United States)

    Silva, Jorge; Willett, Rebecca

    2009-03-01

    This paper addresses the problem of detecting anomalous multivariate co-occurrences using a limited number of unlabeled training observations. A novel method based on using a hypergraph representation of the data is proposed to deal with this very high-dimensional problem. Hypergraphs constitute an important extension of graphs which allow edges to connect more than two vertices simultaneously. A variational Expectation-Maximization algorithm for detecting anomalies directly on the hypergraph domain without any feature selection or dimensionality reduction is presented. The resulting estimate can be used to calculate a measure of anomalousness based on the False Discovery Rate. The algorithm has O(np) computational complexity, where n is the number of training observations and p is the number of potential participants in each co-occurrence event. This efficiency makes the method ideally suited for very high-dimensional settings, and requires no tuning, bandwidth or regularization parameters. The proposed approach is validated on both high-dimensional synthetic data and the Enron email database, where p > 75,000, and it is shown that it can outperform other state-of-the-art methods.

  9. PLEXOS Input Data Generator

    Energy Technology Data Exchange (ETDEWEB)

    2017-02-01

    The PLEXOS Input Data Generator (PIDG) is a tool that enables PLEXOS users to better version their data, automate data processing, collaborate in developing inputs, and transfer data between different production cost modeling and other power systems analysis software. PIDG can process data that is in a generalized format from multiple input sources, including CSV files, PostgreSQL databases, and PSS/E .raw files and write it to an Excel file that can be imported into PLEXOS with only limited manual intervention.

  10. ColloInputGenerator

    DEFF Research Database (Denmark)

    2013-01-01

    This is a very simple program to help you put together input files for use in Gries' (2007) R-based collostruction analysis program. It basically puts together a text file with a frequency list of lexemes in the construction and inserts a column where you can add the corpus frequencies. It requires...... it as input for basic collexeme collostructional analysis (Stefanowitsch & Gries 2003) in Gries' (2007) program. ColloInputGenerator is, in its current state, based on programming commands introduced in Gries (2009). Projected updates: Generation of complete work-ready frequency lists....

  11. Input description for BIOPATH

    International Nuclear Information System (INIS)

    Marklund, J.E.; Bergstroem, U.; Edlund, O.

    1980-01-01

    The computer program BIOPATH describes the flow of radioactivity within a given ecosystem after a postulated release of radioactive material and the resulting dose for specified population groups. The present report accounts for the input data necessary to run BIOPATH. The report also contains descriptions of possible control cards and an input example as well as a short summary of the basic theory.(author)

  12. Input and execution

    International Nuclear Information System (INIS)

    Carr, S.; Lane, G.; Rowling, G.

    1986-11-01

    This document describes the input procedures, input data files and operating instructions for the SYVAC A/C 1.03 computer program. SYVAC A/C 1.03 simulates the groundwater mediated movement of radionuclides from underground facilities for the disposal of low and intermediate level wastes to the accessible environment, and provides an estimate of the subsequent radiological risk to man. (author)

  13. Gestures and multimodal input

    OpenAIRE

    Keates, Simeon; Robinson, Peter

    1999-01-01

    For users with motion impairments, the standard keyboard and mouse arrangement for computer access often presents problems. Other approaches have to be adopted to overcome this. In this paper, we will describe the development of a prototype multimodal input system based on two gestural input channels. Results from extensive user trials of this system are presented. These trials showed that the physical and cognitive loads on the user can quickly become excessive and detrimental to the interac...

  14. On-chip generation of high-dimensional entangled quantum states and their coherent control.

    Science.gov (United States)

    Kues, Michael; Reimer, Christian; Roztocki, Piotr; Cortés, Luis Romero; Sciara, Stefania; Wetzel, Benjamin; Zhang, Yanbing; Cino, Alfonso; Chu, Sai T; Little, Brent E; Moss, David J; Caspani, Lucia; Azaña, José; Morandotti, Roberto

    2017-06-28

    Optical quantum states based on entangled photons are essential for solving questions in fundamental physics and are at the heart of quantum information science. Specifically, the realization of high-dimensional states (D-level quantum systems, that is, qudits, with D > 2) and their control are necessary for fundamental investigations of quantum mechanics, for increasing the sensitivity of quantum imaging schemes, for improving the robustness and key rate of quantum communication protocols, for enabling a richer variety of quantum simulations, and for achieving more efficient and error-tolerant quantum computation. Integrated photonics has recently become a leading platform for the compact, cost-efficient, and stable generation and processing of non-classical optical states. However, so far, integrated entangled quantum sources have been limited to qubits (D = 2). Here we demonstrate on-chip generation of entangled qudit states, where the photons are created in a coherent superposition of multiple high-purity frequency modes. In particular, we confirm the realization of a quantum system with at least one hundred dimensions, formed by two entangled qudits with D = 10. Furthermore, using state-of-the-art, yet off-the-shelf telecommunications components, we introduce a coherent manipulation platform with which to control frequency-entangled states, capable of performing deterministic high-dimensional gate operations. We validate this platform by measuring Bell inequality violations and performing quantum state tomography. Our work enables the generation and processing of high-dimensional quantum states in a single spatial mode.

  15. High-dimensional chaos from self-sustained collisions of solitons

    Energy Technology Data Exchange (ETDEWEB)

    Yildirim, O. Ozgur, E-mail: donhee@seas.harvard.edu, E-mail: oozgury@gmail.com [Cavium, Inc., 600 Nickerson Rd., Marlborough, Massachusetts 01752 (United States); Ham, Donhee, E-mail: donhee@seas.harvard.edu, E-mail: oozgury@gmail.com [Harvard University, 33 Oxford St., Cambridge, Massachusetts 02138 (United States)

    2014-06-16

    We experimentally demonstrate chaos generation based on collisions of electrical solitons on a nonlinear transmission line. The nonlinear line creates solitons, and an amplifier connected to it provides gain to these solitons for their self-excitation and self-sustenance. Critically, the amplifier also provides a mechanism to enable and intensify collisions among solitons. These collisional interactions are of intrinsically nonlinear nature, modulating the phase and amplitude of solitons, thus causing chaos. This chaos generated by the exploitation of the nonlinear wave phenomena is inherently high-dimensional, which we also demonstrate.

  16. A novel algorithm of artificial immune system for high-dimensional function numerical optimization

    Institute of Scientific and Technical Information of China (English)

    DU Haifeng; GONG Maoguo; JIAO Licheng; LIU Ruochen

    2005-01-01

    Based on the clonal selection theory and immune memory theory, a novel artificial immune system algorithm, immune memory clonal programming algorithm (IMCPA), is put forward. Using the theorem of Markov chain, it is proved that IMCPA is convergent. Compared with some other evolutionary programming algorithms (like Breeder genetic algorithm), IMCPA is shown to be an evolutionary strategy capable of solving complex machine learning tasks, like high-dimensional function optimization, which maintains the diversity of the population and avoids prematurity to some extent, and has a higher convergence speed.

  17. Computing and visualizing time-varying merge trees for high-dimensional data

    Energy Technology Data Exchange (ETDEWEB)

    Oesterling, Patrick [Univ. of Leipzig (Germany); Heine, Christian [Univ. of Kaiserslautern (Germany); Weber, Gunther H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Morozov, Dmitry [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Scheuermann, Gerik [Univ. of Leipzig (Germany)

    2017-06-03

    We introduce a new method that identifies and tracks features in arbitrary dimensions using the merge tree -- a structure for identifying topological features based on thresholding in scalar fields. This method analyzes the evolution of features of the function by tracking changes in the merge tree and relates features by matching subtrees between consecutive time steps. Using the time-varying merge tree, we present a structural visualization of the changing function that illustrates both features and their temporal evolution. We demonstrate the utility of our approach by applying it to temporal cluster analysis of high-dimensional point clouds.

  18. Non-Asymptotic Oracle Inequalities for the High-Dimensional Cox Regression via Lasso.

    Science.gov (United States)

    Kong, Shengchun; Nan, Bin

    2014-01-01

    We consider finite sample properties of the regularized high-dimensional Cox regression via lasso. Existing literature focuses on linear models or generalized linear models with Lipschitz loss functions, where the empirical risk functions are the summations of independent and identically distributed (iid) losses. The summands in the negative log partial likelihood function for censored survival data, however, are neither iid nor Lipschitz.We first approximate the negative log partial likelihood function by a sum of iid non-Lipschitz terms, then derive the non-asymptotic oracle inequalities for the lasso penalized Cox regression using pointwise arguments to tackle the difficulties caused by lacking iid Lipschitz losses.

  19. High-dimensional data: p >> n in mathematical statistics and bio-medical applications

    OpenAIRE

    Van De Geer, Sara A.; Van Houwelingen, Hans C.

    2004-01-01

    The workshop 'High-dimensional data: p >> n in mathematical statistics and bio-medical applications' was held at the Lorentz Center in Leiden from 9 to 20 September 2002. This special issue of Bernoulli contains a selection of papers presented at that workshop. ¶ The introduction of high-throughput micro-array technology to measure gene-expression levels and the publication of the pioneering paper by Golub et al. (1999) has brought to life a whole new branch of data analysis under the name of...

  20. Bayesian Multiresolution Variable Selection for Ultra-High Dimensional Neuroimaging Data.

    Science.gov (United States)

    Zhao, Yize; Kang, Jian; Long, Qi

    2018-01-01

    Ultra-high dimensional variable selection has become increasingly important in analysis of neuroimaging data. For example, in the Autism Brain Imaging Data Exchange (ABIDE) study, neuroscientists are interested in identifying important biomarkers for early detection of the autism spectrum disorder (ASD) using high resolution brain images that include hundreds of thousands voxels. However, most existing methods are not feasible for solving this problem due to their extensive computational costs. In this work, we propose a novel multiresolution variable selection procedure under a Bayesian probit regression framework. It recursively uses posterior samples for coarser-scale variable selection to guide the posterior inference on finer-scale variable selection, leading to very efficient Markov chain Monte Carlo (MCMC) algorithms. The proposed algorithms are computationally feasible for ultra-high dimensional data. Also, our model incorporates two levels of structural information into variable selection using Ising priors: the spatial dependence between voxels and the functional connectivity between anatomical brain regions. Applied to the resting state functional magnetic resonance imaging (R-fMRI) data in the ABIDE study, our methods identify voxel-level imaging biomarkers highly predictive of the ASD, which are biologically meaningful and interpretable. Extensive simulations also show that our methods achieve better performance in variable selection compared to existing methods.

  1. Energy Efficient MAC Scheme for Wireless Sensor Networks with High-Dimensional Data Aggregate

    Directory of Open Access Journals (Sweden)

    Seokhoon Kim

    2015-01-01

    Full Text Available This paper presents a novel and sustainable medium access control (MAC scheme for wireless sensor network (WSN systems that process high-dimensional aggregated data. Based on a preamble signal and buffer threshold analysis, it maximizes the energy efficiency of the wireless sensor devices which have limited energy resources. The proposed group management MAC (GM-MAC approach not only sets the buffer threshold value of a sensor device to be reciprocal to the preamble signal but also sets a transmittable group value to each sensor device by using the preamble signal of the sink node. The primary difference between the previous and the proposed approach is that existing state-of-the-art schemes use duty cycle and sleep mode to save energy consumption of individual sensor devices, whereas the proposed scheme employs the group management MAC scheme for sensor devices to maximize the overall energy efficiency of the whole WSN systems by minimizing the energy consumption of sensor devices located near the sink node. Performance evaluations show that the proposed scheme outperforms the previous schemes in terms of active time of sensor devices, transmission delay, control overhead, and energy consumption. Therefore, the proposed scheme is suitable for sensor devices in a variety of wireless sensor networking environments with high-dimensional data aggregate.

  2. Selecting Optimal Feature Set in High-Dimensional Data by Swarm Search

    Directory of Open Access Journals (Sweden)

    Simon Fong

    2013-01-01

    Full Text Available Selecting the right set of features from data of high dimensionality for inducing an accurate classification model is a tough computational challenge. It is almost a NP-hard problem as the combinations of features escalate exponentially as the number of features increases. Unfortunately in data mining, as well as other engineering applications and bioinformatics, some data are described by a long array of features. Many feature subset selection algorithms have been proposed in the past, but not all of them are effective. Since it takes seemingly forever to use brute force in exhaustively trying every possible combination of features, stochastic optimization may be a solution. In this paper, we propose a new feature selection scheme called Swarm Search to find an optimal feature set by using metaheuristics. The advantage of Swarm Search is its flexibility in integrating any classifier into its fitness function and plugging in any metaheuristic algorithm to facilitate heuristic search. Simulation experiments are carried out by testing the Swarm Search over some high-dimensional datasets, with different classification algorithms and various metaheuristic algorithms. The comparative experiment results show that Swarm Search is able to attain relatively low error rates in classification without shrinking the size of the feature subset to its minimum.

  3. The validation and assessment of machine learning: a game of prediction from high-dimensional data.

    Directory of Open Access Journals (Sweden)

    Tune H Pers

    Full Text Available In applied statistics, tools from machine learning are popular for analyzing complex and high-dimensional data. However, few theoretical results are available that could guide to the appropriate machine learning tool in a new application. Initial development of an overall strategy thus often implies that multiple methods are tested and compared on the same set of data. This is particularly difficult in situations that are prone to over-fitting where the number of subjects is low compared to the number of potential predictors. The article presents a game which provides some grounds for conducting a fair model comparison. Each player selects a modeling strategy for predicting individual response from potential predictors. A strictly proper scoring rule, bootstrap cross-validation, and a set of rules are used to make the results obtained with different strategies comparable. To illustrate the ideas, the game is applied to data from the Nugenob Study where the aim is to predict the fat oxidation capacity based on conventional factors and high-dimensional metabolomics data. Three players have chosen to use support vector machines, LASSO, and random forests, respectively.

  4. High-dimensional quantum key distribution with the entangled single-photon-added coherent state

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yang [Zhengzhou Information Science and Technology Institute, Zhengzhou, 450001 (China); Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Bao, Wan-Su, E-mail: 2010thzz@sina.com [Zhengzhou Information Science and Technology Institute, Zhengzhou, 450001 (China); Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Bao, Hai-Ze; Zhou, Chun; Jiang, Mu-Sheng; Li, Hong-Wei [Zhengzhou Information Science and Technology Institute, Zhengzhou, 450001 (China); Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2017-04-25

    High-dimensional quantum key distribution (HD-QKD) can generate more secure bits for one detection event so that it can achieve long distance key distribution with a high secret key capacity. In this Letter, we present a decoy state HD-QKD scheme with the entangled single-photon-added coherent state (ESPACS) source. We present two tight formulas to estimate the single-photon fraction of postselected events and Eve's Holevo information and derive lower bounds on the secret key capacity and the secret key rate of our protocol. We also present finite-key analysis for our protocol by using the Chernoff bound. Our numerical results show that our protocol using one decoy state can perform better than that of previous HD-QKD protocol with the spontaneous parametric down conversion (SPDC) using two decoy states. Moreover, when considering finite resources, the advantage is more obvious. - Highlights: • Implement the single-photon-added coherent state source into the high-dimensional quantum key distribution. • Enhance both the secret key capacity and the secret key rate compared with previous schemes. • Show an excellent performance in view of statistical fluctuations.

  5. A Feature Subset Selection Method Based On High-Dimensional Mutual Information

    Directory of Open Access Journals (Sweden)

    Chee Keong Kwoh

    2011-04-01

    Full Text Available Feature selection is an important step in building accurate classifiers and provides better understanding of the data sets. In this paper, we propose a feature subset selection method based on high-dimensional mutual information. We also propose to use the entropy of the class attribute as a criterion to determine the appropriate subset of features when building classifiers. We prove that if the mutual information between a feature set X and the class attribute Y equals to the entropy of Y , then X is a Markov Blanket of Y . We show that in some cases, it is infeasible to approximate the high-dimensional mutual information with algebraic combinations of pairwise mutual information in any forms. In addition, the exhaustive searches of all combinations of features are prerequisite for finding the optimal feature subsets for classifying these kinds of data sets. We show that our approach outperforms existing filter feature subset selection methods for most of the 24 selected benchmark data sets.

  6. Using High-Dimensional Image Models to Perform Highly Undetectable Steganography

    Science.gov (United States)

    Pevný, Tomáš; Filler, Tomáš; Bas, Patrick

    This paper presents a complete methodology for designing practical and highly-undetectable stegosystems for real digital media. The main design principle is to minimize a suitably-defined distortion by means of efficient coding algorithm. The distortion is defined as a weighted difference of extended state-of-the-art feature vectors already used in steganalysis. This allows us to "preserve" the model used by steganalyst and thus be undetectable even for large payloads. This framework can be efficiently implemented even when the dimensionality of the feature set used by the embedder is larger than 107. The high dimensional model is necessary to avoid known security weaknesses. Although high-dimensional models might be problem in steganalysis, we explain, why they are acceptable in steganography. As an example, we introduce HUGO, a new embedding algorithm for spatial-domain digital images and we contrast its performance with LSB matching. On the BOWS2 image database and in contrast with LSB matching, HUGO allows the embedder to hide 7× longer message with the same level of security level.

  7. Quantum secret sharing based on modulated high-dimensional time-bin entanglement

    International Nuclear Information System (INIS)

    Takesue, Hiroki; Inoue, Kyo

    2006-01-01

    We propose a scheme for quantum secret sharing (QSS) that uses a modulated high-dimensional time-bin entanglement. By modulating the relative phase randomly by {0,π}, a sender with the entanglement source can randomly change the sign of the correlation of the measurement outcomes obtained by two distant recipients. The two recipients must cooperate if they are to obtain the sign of the correlation, which is used as a secret key. We show that our scheme is secure against intercept-and-resend (IR) and beam splitting attacks by an outside eavesdropper thanks to the nonorthogonality of high-dimensional time-bin entangled states. We also show that a cheating attempt based on an IR attack by one of the recipients can be detected by changing the dimension of the time-bin entanglement randomly and inserting two 'vacant' slots between the packets. Then, cheating attempts can be detected by monitoring the count rate in the vacant slots. The proposed scheme has better experimental feasibility than previously proposed entanglement-based QSS schemes

  8. Similarity measurement method of high-dimensional data based on normalized net lattice subspace

    Institute of Scientific and Technical Information of China (English)

    Li Wenfa; Wang Gongming; Li Ke; Huang Su

    2017-01-01

    The performance of conventional similarity measurement methods is affected seriously by the curse of dimensionality of high-dimensional data.The reason is that data difference between sparse and noisy dimensionalities occupies a large proportion of the similarity, leading to the dissimilarities between any results.A similarity measurement method of high-dimensional data based on normalized net lattice subspace is proposed.The data range of each dimension is divided into several intervals, and the components in different dimensions are mapped onto the corresponding interval.Only the component in the same or adjacent interval is used to calculate the similarity.To validate this meth-od, three data types are used, and seven common similarity measurement methods are compared. The experimental result indicates that the relative difference of the method is increasing with the di-mensionality and is approximately two or three orders of magnitude higher than the conventional method.In addition, the similarity range of this method in different dimensions is [0, 1], which is fit for similarity analysis after dimensionality reduction.

  9. The cross-validated AUC for MCP-logistic regression with high-dimensional data.

    Science.gov (United States)

    Jiang, Dingfeng; Huang, Jian; Zhang, Ying

    2013-10-01

    We propose a cross-validated area under the receiving operator characteristic (ROC) curve (CV-AUC) criterion for tuning parameter selection for penalized methods in sparse, high-dimensional logistic regression models. We use this criterion in combination with the minimax concave penalty (MCP) method for variable selection. The CV-AUC criterion is specifically designed for optimizing the classification performance for binary outcome data. To implement the proposed approach, we derive an efficient coordinate descent algorithm to compute the MCP-logistic regression solution surface. Simulation studies are conducted to evaluate the finite sample performance of the proposed method and its comparison with the existing methods including the Akaike information criterion (AIC), Bayesian information criterion (BIC) or Extended BIC (EBIC). The model selected based on the CV-AUC criterion tends to have a larger predictive AUC and smaller classification error than those with tuning parameters selected using the AIC, BIC or EBIC. We illustrate the application of the MCP-logistic regression with the CV-AUC criterion on three microarray datasets from the studies that attempt to identify genes related to cancers. Our simulation studies and data examples demonstrate that the CV-AUC is an attractive method for tuning parameter selection for penalized methods in high-dimensional logistic regression models.

  10. An Improved Ensemble Learning Method for Classifying High-Dimensional and Imbalanced Biomedicine Data.

    Science.gov (United States)

    Yu, Hualong; Ni, Jun

    2014-01-01

    Training classifiers on skewed data can be technically challenging tasks, especially if the data is high-dimensional simultaneously, the tasks can become more difficult. In biomedicine field, skewed data type often appears. In this study, we try to deal with this problem by combining asymmetric bagging ensemble classifier (asBagging) that has been presented in previous work and an improved random subspace (RS) generation strategy that is called feature subspace (FSS). Specifically, FSS is a novel method to promote the balance level between accuracy and diversity of base classifiers in asBagging. In view of the strong generalization capability of support vector machine (SVM), we adopt it to be base classifier. Extensive experiments on four benchmark biomedicine data sets indicate that the proposed ensemble learning method outperforms many baseline approaches in terms of Accuracy, F-measure, G-mean and AUC evaluation criterions, thus it can be regarded as an effective and efficient tool to deal with high-dimensional and imbalanced biomedical data.

  11. Compact Representation of High-Dimensional Feature Vectors for Large-Scale Image Recognition and Retrieval.

    Science.gov (United States)

    Zhang, Yu; Wu, Jianxin; Cai, Jianfei

    2016-05-01

    In large-scale visual recognition and image retrieval tasks, feature vectors, such as Fisher vector (FV) or the vector of locally aggregated descriptors (VLAD), have achieved state-of-the-art results. However, the combination of the large numbers of examples and high-dimensional vectors necessitates dimensionality reduction, in order to reduce its storage and CPU costs to a reasonable range. In spite of the popularity of various feature compression methods, this paper shows that the feature (dimension) selection is a better choice for high-dimensional FV/VLAD than the feature (dimension) compression methods, e.g., product quantization. We show that strong correlation among the feature dimensions in the FV and the VLAD may not exist, which renders feature selection a natural choice. We also show that, many dimensions in FV/VLAD are noise. Throwing them away using feature selection is better than compressing them and useful dimensions altogether using feature compression methods. To choose features, we propose an efficient importance sorting algorithm considering both the supervised and unsupervised cases, for visual recognition and image retrieval, respectively. Combining with the 1-bit quantization, feature selection has achieved both higher accuracy and less computational cost than feature compression methods, such as product quantization, on the FV and the VLAD image representations.

  12. High-dimensional quantum key distribution with the entangled single-photon-added coherent state

    International Nuclear Information System (INIS)

    Wang, Yang; Bao, Wan-Su; Bao, Hai-Ze; Zhou, Chun; Jiang, Mu-Sheng; Li, Hong-Wei

    2017-01-01

    High-dimensional quantum key distribution (HD-QKD) can generate more secure bits for one detection event so that it can achieve long distance key distribution with a high secret key capacity. In this Letter, we present a decoy state HD-QKD scheme with the entangled single-photon-added coherent state (ESPACS) source. We present two tight formulas to estimate the single-photon fraction of postselected events and Eve's Holevo information and derive lower bounds on the secret key capacity and the secret key rate of our protocol. We also present finite-key analysis for our protocol by using the Chernoff bound. Our numerical results show that our protocol using one decoy state can perform better than that of previous HD-QKD protocol with the spontaneous parametric down conversion (SPDC) using two decoy states. Moreover, when considering finite resources, the advantage is more obvious. - Highlights: • Implement the single-photon-added coherent state source into the high-dimensional quantum key distribution. • Enhance both the secret key capacity and the secret key rate compared with previous schemes. • Show an excellent performance in view of statistical fluctuations.

  13. High-Dimensional Single-Photon Quantum Gates: Concepts and Experiments.

    Science.gov (United States)

    Babazadeh, Amin; Erhard, Manuel; Wang, Feiran; Malik, Mehul; Nouroozi, Rahman; Krenn, Mario; Zeilinger, Anton

    2017-11-03

    Transformations on quantum states form a basic building block of every quantum information system. From photonic polarization to two-level atoms, complete sets of quantum gates for a variety of qubit systems are well known. For multilevel quantum systems beyond qubits, the situation is more challenging. The orbital angular momentum modes of photons comprise one such high-dimensional system for which generation and measurement techniques are well studied. However, arbitrary transformations for such quantum states are not known. Here we experimentally demonstrate a four-dimensional generalization of the Pauli X gate and all of its integer powers on single photons carrying orbital angular momentum. Together with the well-known Z gate, this forms the first complete set of high-dimensional quantum gates implemented experimentally. The concept of the X gate is based on independent access to quantum states with different parities and can thus be generalized to other photonic degrees of freedom and potentially also to other quantum systems.

  14. TESTING HIGH-DIMENSIONAL COVARIANCE MATRICES, WITH APPLICATION TO DETECTING SCHIZOPHRENIA RISK GENES.

    Science.gov (United States)

    Zhu, Lingxue; Lei, Jing; Devlin, Bernie; Roeder, Kathryn

    2017-09-01

    Scientists routinely compare gene expression levels in cases versus controls in part to determine genes associated with a disease. Similarly, detecting case-control differences in co-expression among genes can be critical to understanding complex human diseases; however statistical methods have been limited by the high dimensional nature of this problem. In this paper, we construct a sparse-Leading-Eigenvalue-Driven (sLED) test for comparing two high-dimensional covariance matrices. By focusing on the spectrum of the differential matrix, sLED provides a novel perspective that accommodates what we assume to be common, namely sparse and weak signals in gene expression data, and it is closely related with Sparse Principal Component Analysis. We prove that sLED achieves full power asymptotically under mild assumptions, and simulation studies verify that it outperforms other existing procedures under many biologically plausible scenarios. Applying sLED to the largest gene-expression dataset obtained from post-mortem brain tissue from Schizophrenia patients and controls, we provide a novel list of genes implicated in Schizophrenia and reveal intriguing patterns in gene co-expression change for Schizophrenia subjects. We also illustrate that sLED can be generalized to compare other gene-gene "relationship" matrices that are of practical interest, such as the weighted adjacency matrices.

  15. Latent class models for joint analysis of disease prevalence and high-dimensional semicontinuous biomarker data.

    Science.gov (United States)

    Zhang, Bo; Chen, Zhen; Albert, Paul S

    2012-01-01

    High-dimensional biomarker data are often collected in epidemiological studies when assessing the association between biomarkers and human disease is of interest. We develop a latent class modeling approach for joint analysis of high-dimensional semicontinuous biomarker data and a binary disease outcome. To model the relationship between complex biomarker expression patterns and disease risk, we use latent risk classes to link the 2 modeling components. We characterize complex biomarker-specific differences through biomarker-specific random effects, so that different biomarkers can have different baseline (low-risk) values as well as different between-class differences. The proposed approach also accommodates data features that are common in environmental toxicology and other biomarker exposure data, including a large number of biomarkers, numerous zero values, and complex mean-variance relationship in the biomarkers levels. A Monte Carlo EM (MCEM) algorithm is proposed for parameter estimation. Both the MCEM algorithm and model selection procedures are shown to work well in simulations and applications. In applying the proposed approach to an epidemiological study that examined the relationship between environmental polychlorinated biphenyl (PCB) exposure and the risk of endometriosis, we identified a highly significant overall effect of PCB concentrations on the risk of endometriosis.

  16. Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications.

    Science.gov (United States)

    Tao, Chenyang; Nichols, Thomas E; Hua, Xue; Ching, Christopher R K; Rolls, Edmund T; Thompson, Paul M; Feng, Jianfeng

    2017-01-01

    We propose a generalized reduced rank latent factor regression model (GRRLF) for the analysis of tensor field responses and high dimensional covariates. The model is motivated by the need from imaging-genetic studies to identify genetic variants that are associated with brain imaging phenotypes, often in the form of high dimensional tensor fields. GRRLF identifies from the structure in the data the effective dimensionality of the data, and then jointly performs dimension reduction of the covariates, dynamic identification of latent factors, and nonparametric estimation of both covariate and latent response fields. After accounting for the latent and covariate effects, GRLLF performs a nonparametric test on the remaining factor of interest. GRRLF provides a better factorization of the signals compared with common solutions, and is less susceptible to overfitting because it exploits the effective dimensionality. The generality and the flexibility of GRRLF also allow various statistical models to be handled in a unified framework and solutions can be efficiently computed. Within the field of neuroimaging, it improves the sensitivity for weak signals and is a promising alternative to existing approaches. The operation of the framework is demonstrated with both synthetic datasets and a real-world neuroimaging example in which the effects of a set of genes on the structure of the brain at the voxel level were measured, and the results compared favorably with those from existing approaches. Copyright © 2016. Published by Elsevier Inc.

  17. Challenges and Approaches to Statistical Design and Inference in High Dimensional Investigations

    Science.gov (United States)

    Garrett, Karen A.; Allison, David B.

    2015-01-01

    Summary Advances in modern technologies have facilitated high-dimensional experiments (HDEs) that generate tremendous amounts of genomic, proteomic, and other “omic” data. HDEs involving whole-genome sequences and polymorphisms, expression levels of genes, protein abundance measurements, and combinations thereof have become a vanguard for new analytic approaches to the analysis of HDE data. Such situations demand creative approaches to the processes of statistical inference, estimation, prediction, classification, and study design. The novel and challenging biological questions asked from HDE data have resulted in many specialized analytic techniques being developed. This chapter discusses some of the unique statistical challenges facing investigators studying high-dimensional biology, and describes some approaches being developed by statistical scientists. We have included some focus on the increasing interest in questions involving testing multiple propositions simultaneously, appropriate inferential indicators for the types of questions biologists are interested in, and the need for replication of results across independent studies, investigators, and settings. A key consideration inherent throughout is the challenge in providing methods that a statistician judges to be sound and a biologist finds informative. PMID:19588106

  18. Challenges and approaches to statistical design and inference in high-dimensional investigations.

    Science.gov (United States)

    Gadbury, Gary L; Garrett, Karen A; Allison, David B

    2009-01-01

    Advances in modern technologies have facilitated high-dimensional experiments (HDEs) that generate tremendous amounts of genomic, proteomic, and other "omic" data. HDEs involving whole-genome sequences and polymorphisms, expression levels of genes, protein abundance measurements, and combinations thereof have become a vanguard for new analytic approaches to the analysis of HDE data. Such situations demand creative approaches to the processes of statistical inference, estimation, prediction, classification, and study design. The novel and challenging biological questions asked from HDE data have resulted in many specialized analytic techniques being developed. This chapter discusses some of the unique statistical challenges facing investigators studying high-dimensional biology and describes some approaches being developed by statistical scientists. We have included some focus on the increasing interest in questions involving testing multiple propositions simultaneously, appropriate inferential indicators for the types of questions biologists are interested in, and the need for replication of results across independent studies, investigators, and settings. A key consideration inherent throughout is the challenge in providing methods that a statistician judges to be sound and a biologist finds informative.

  19. Innovation Rather than Improvement: A Solvable High-Dimensional Model Highlights the Limitations of Scalar Fitness

    Science.gov (United States)

    Tikhonov, Mikhail; Monasson, Remi

    2018-01-01

    Much of our understanding of ecological and evolutionary mechanisms derives from analysis of low-dimensional models: with few interacting species, or few axes defining "fitness". It is not always clear to what extent the intuition derived from low-dimensional models applies to the complex, high-dimensional reality. For instance, most naturally occurring microbial communities are strikingly diverse, harboring a large number of coexisting species, each of which contributes to shaping the environment of others. Understanding the eco-evolutionary interplay in these systems is an important challenge, and an exciting new domain for statistical physics. Recent work identified a promising new platform for investigating highly diverse ecosystems, based on the classic resource competition model of MacArthur. Here, we describe how the same analytical framework can be used to study evolutionary questions. Our analysis illustrates how, at high dimension, the intuition promoted by a one-dimensional (scalar) notion of fitness can become misleading. Specifically, while the low-dimensional picture emphasizes organism cost or efficiency, we exhibit a regime where cost becomes irrelevant for survival, and link this observation to generic properties of high-dimensional geometry.

  20. AucPR: An AUC-based approach using penalized regression for disease prediction with high-dimensional omics data

    OpenAIRE

    Yu, Wenbao; Park, Taesung

    2014-01-01

    Motivation It is common to get an optimal combination of markers for disease classification and prediction when multiple markers are available. Many approaches based on the area under the receiver operating characteristic curve (AUC) have been proposed. Existing works based on AUC in a high-dimensional context depend mainly on a non-parametric, smooth approximation of AUC, with no work using a parametric AUC-based approach, for high-dimensional data. Results We propose an AUC-based approach u...

  1. High-Dimensional Analysis of Convex Optimization-Based Massive MIMO Decoders

    KAUST Repository

    Ben Atitallah, Ismail

    2017-04-01

    A wide range of modern large-scale systems relies on recovering a signal from noisy linear measurements. In many applications, the useful signal has inherent properties, such as sparsity, low-rankness, or boundedness, and making use of these properties and structures allow a more efficient recovery. Hence, a significant amount of work has been dedicated to developing and analyzing algorithms that can take advantage of the signal structure. Especially, since the advent of Compressed Sensing (CS) there has been significant progress towards this direction. Generally speaking, the signal structure can be harnessed by solving an appropriate regularized or constrained M-estimator. In modern Multi-input Multi-output (MIMO) communication systems, all transmitted signals are drawn from finite constellations and are thus bounded. Besides, most recent modulation schemes such as Generalized Space Shift Keying (GSSK) or Generalized Spatial Modulation (GSM) yield signals that are inherently sparse. In the recovery procedure, boundedness and sparsity can be promoted by using the ℓ1 norm regularization and by imposing an ℓ∞ norm constraint respectively. In this thesis, we propose novel optimization algorithms to recover certain classes of structured signals with emphasis on MIMO communication systems. The exact analysis permits a clear characterization of how well these systems perform. Also, it allows an automatic tuning of the parameters. In each context, we define the appropriate performance metrics and we analyze them exactly in the High Dimentional Regime (HDR). The framework we use for the analysis is based on Gaussian process inequalities; in particular, on a new strong and tight version of a classical comparison inequality (due to Gordon, 1988) in the presence of additional convexity assumptions. The new framework that emerged from this inequality is coined as Convex Gaussian Min-max Theorem (CGMT).

  2. A non-linear dimension reduction methodology for generating data-driven stochastic input models

    Science.gov (United States)

    Ganapathysubramanian, Baskar; Zabaras, Nicholas

    2008-06-01

    Stochastic analysis of random heterogeneous media (polycrystalline materials, porous media, functionally graded materials) provides information of significance only if realistic input models of the topology and property variations are used. This paper proposes a framework to construct such input stochastic models for the topology and thermal diffusivity variations in heterogeneous media using a data-driven strategy. Given a set of microstructure realizations (input samples) generated from given statistical information about the medium topology, the framework constructs a reduced-order stochastic representation of the thermal diffusivity. This problem of constructing a low-dimensional stochastic representation of property variations is analogous to the problem of manifold learning and parametric fitting of hyper-surfaces encountered in image processing and psychology. Denote by M the set of microstructures that satisfy the given experimental statistics. A non-linear dimension reduction strategy is utilized to map M to a low-dimensional region, A. We first show that M is a compact manifold embedded in a high-dimensional input space Rn. An isometric mapping F from M to a low-dimensional, compact, connected set A⊂Rd(d≪n) is constructed. Given only a finite set of samples of the data, the methodology uses arguments from graph theory and differential geometry to construct the isometric transformation F:M→A. Asymptotic convergence of the representation of M by A is shown. This mapping F serves as an accurate, low-dimensional, data-driven representation of the property variations. The reduced-order model of the material topology and thermal diffusivity variations is subsequently used as an input in the solution of stochastic partial differential equations that describe the evolution of dependant variables. A sparse grid collocation strategy (Smolyak algorithm) is utilized to solve these stochastic equations efficiently. We showcase the methodology by constructing low

  3. A non-linear dimension reduction methodology for generating data-driven stochastic input models

    International Nuclear Information System (INIS)

    Ganapathysubramanian, Baskar; Zabaras, Nicholas

    2008-01-01

    Stochastic analysis of random heterogeneous media (polycrystalline materials, porous media, functionally graded materials) provides information of significance only if realistic input models of the topology and property variations are used. This paper proposes a framework to construct such input stochastic models for the topology and thermal diffusivity variations in heterogeneous media using a data-driven strategy. Given a set of microstructure realizations (input samples) generated from given statistical information about the medium topology, the framework constructs a reduced-order stochastic representation of the thermal diffusivity. This problem of constructing a low-dimensional stochastic representation of property variations is analogous to the problem of manifold learning and parametric fitting of hyper-surfaces encountered in image processing and psychology. Denote by M the set of microstructures that satisfy the given experimental statistics. A non-linear dimension reduction strategy is utilized to map M to a low-dimensional region, A. We first show that M is a compact manifold embedded in a high-dimensional input space R n . An isometric mapping F from M to a low-dimensional, compact, connected set A is contained in R d (d<< n) is constructed. Given only a finite set of samples of the data, the methodology uses arguments from graph theory and differential geometry to construct the isometric transformation F:M→A. Asymptotic convergence of the representation of M by A is shown. This mapping F serves as an accurate, low-dimensional, data-driven representation of the property variations. The reduced-order model of the material topology and thermal diffusivity variations is subsequently used as an input in the solution of stochastic partial differential equations that describe the evolution of dependant variables. A sparse grid collocation strategy (Smolyak algorithm) is utilized to solve these stochastic equations efficiently. We showcase the methodology

  4. High dimensional biological data retrieval optimization with NoSQL technology

    Science.gov (United States)

    2014-01-01

    Background High-throughput transcriptomic data generated by microarray experiments is the most abundant and frequently stored kind of data currently used in translational medicine studies. Although microarray data is supported in data warehouses such as tranSMART, when querying relational databases for hundreds of different patient gene expression records queries are slow due to poor performance. Non-relational data models, such as the key-value model implemented in NoSQL databases, hold promise to be more performant solutions. Our motivation is to improve the performance of the tranSMART data warehouse with a view to supporting Next Generation Sequencing data. Results In this paper we introduce a new data model better suited for high-dimensional data storage and querying, optimized for database scalability and performance. We have designed a key-value pair data model to support faster queries over large-scale microarray data and implemented the model using HBase, an implementation of Google's BigTable storage system. An experimental performance comparison was carried out against the traditional relational data model implemented in both MySQL Cluster and MongoDB, using a large publicly available transcriptomic data set taken from NCBI GEO concerning Multiple Myeloma. Our new key-value data model implemented on HBase exhibits an average 5.24-fold increase in high-dimensional biological data query performance compared to the relational model implemented on MySQL Cluster, and an average 6.47-fold increase on query performance on MongoDB. Conclusions The performance evaluation found that the new key-value data model, in particular its implementation in HBase, outperforms the relational model currently implemented in tranSMART. We propose that NoSQL technology holds great promise for large-scale data management, in particular for high-dimensional biological data such as that demonstrated in the performance evaluation described in this paper. We aim to use this new data

  5. Exploring high dimensional data with Butterfly: a novel classification algorithm based on discrete dynamical systems.

    Science.gov (United States)

    Geraci, Joseph; Dharsee, Moyez; Nuin, Paulo; Haslehurst, Alexandria; Koti, Madhuri; Feilotter, Harriet E; Evans, Ken

    2014-03-01

    We introduce a novel method for visualizing high dimensional data via a discrete dynamical system. This method provides a 2D representation of the relationship between subjects according to a set of variables without geometric projections, transformed axes or principal components. The algorithm exploits a memory-type mechanism inherent in a certain class of discrete dynamical systems collectively referred to as the chaos game that are closely related to iterative function systems. The goal of the algorithm was to create a human readable representation of high dimensional patient data that was capable of detecting unrevealed subclusters of patients from within anticipated classifications. This provides a mechanism to further pursue a more personalized exploration of pathology when used with medical data. For clustering and classification protocols, the dynamical system portion of the algorithm is designed to come after some feature selection filter and before some model evaluation (e.g. clustering accuracy) protocol. In the version given here, a univariate features selection step is performed (in practice more complex feature selection methods are used), a discrete dynamical system is driven by this reduced set of variables (which results in a set of 2D cluster models), these models are evaluated for their accuracy (according to a user-defined binary classification) and finally a visual representation of the top classification models are returned. Thus, in addition to the visualization component, this methodology can be used for both supervised and unsupervised machine learning as the top performing models are returned in the protocol we describe here. Butterfly, the algorithm we introduce and provide working code for, uses a discrete dynamical system to classify high dimensional data and provide a 2D representation of the relationship between subjects. We report results on three datasets (two in the article; one in the appendix) including a public lung cancer

  6. High dimensional biological data retrieval optimization with NoSQL technology.

    Science.gov (United States)

    Wang, Shicai; Pandis, Ioannis; Wu, Chao; He, Sijin; Johnson, David; Emam, Ibrahim; Guitton, Florian; Guo, Yike

    2014-01-01

    High-throughput transcriptomic data generated by microarray experiments is the most abundant and frequently stored kind of data currently used in translational medicine studies. Although microarray data is supported in data warehouses such as tranSMART, when querying relational databases for hundreds of different patient gene expression records queries are slow due to poor performance. Non-relational data models, such as the key-value model implemented in NoSQL databases, hold promise to be more performant solutions. Our motivation is to improve the performance of the tranSMART data warehouse with a view to supporting Next Generation Sequencing data. In this paper we introduce a new data model better suited for high-dimensional data storage and querying, optimized for database scalability and performance. We have designed a key-value pair data model to support faster queries over large-scale microarray data and implemented the model using HBase, an implementation of Google's BigTable storage system. An experimental performance comparison was carried out against the traditional relational data model implemented in both MySQL Cluster and MongoDB, using a large publicly available transcriptomic data set taken from NCBI GEO concerning Multiple Myeloma. Our new key-value data model implemented on HBase exhibits an average 5.24-fold increase in high-dimensional biological data query performance compared to the relational model implemented on MySQL Cluster, and an average 6.47-fold increase on query performance on MongoDB. The performance evaluation found that the new key-value data model, in particular its implementation in HBase, outperforms the relational model currently implemented in tranSMART. We propose that NoSQL technology holds great promise for large-scale data management, in particular for high-dimensional biological data such as that demonstrated in the performance evaluation described in this paper. We aim to use this new data model as a basis for migrating

  7. Penalized estimation for competing risks regression with applications to high-dimensional covariates

    DEFF Research Database (Denmark)

    Ambrogi, Federico; Scheike, Thomas H.

    2016-01-01

    of competing events. The direct binomial regression model of Scheike and others (2008. Predicting cumulative incidence probability by direct binomial regression. Biometrika 95: (1), 205-220) is reformulated in a penalized framework to possibly fit a sparse regression model. The developed approach is easily...... Research 19: (1), 29-51), the research regarding competing risks is less developed (Binder and others, 2009. Boosting for high-dimensional time-to-event data with competing risks. Bioinformatics 25: (7), 890-896). The aim of this work is to consider how to do penalized regression in the presence...... implementable using existing high-performance software to do penalized regression. Results from simulation studies are presented together with an application to genomic data when the endpoint is progression-free survival. An R function is provided to perform regularized competing risks regression according...

  8. Entanglement dynamics of high-dimensional bipartite field states inside the cavities in dissipative environments

    Energy Technology Data Exchange (ETDEWEB)

    Tahira, Rabia; Ikram, Manzoor; Zubairy, M Suhail [Centre for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan); Bougouffa, Smail [Department of Physics, Faculty of Science, Taibah University, PO Box 30002, Madinah (Saudi Arabia)

    2010-02-14

    We investigate the phenomenon of sudden death of entanglement in a high-dimensional bipartite system subjected to dissipative environments with an arbitrary initial pure entangled state between two fields in the cavities. We find that in a vacuum reservoir, the presence of the state where one or more than one (two) photons in each cavity are present is a necessary condition for the sudden death of entanglement. Otherwise entanglement remains for infinite time and decays asymptotically with the decay of individual qubits. For pure two-qubit entangled states in a thermal environment, we observe that sudden death of entanglement always occurs. The sudden death time of the entangled states is related to the number of photons in the cavities, the temperature of the reservoir and the initial preparation of the entangled states.

  9. Entanglement dynamics of high-dimensional bipartite field states inside the cavities in dissipative environments

    International Nuclear Information System (INIS)

    Tahira, Rabia; Ikram, Manzoor; Zubairy, M Suhail; Bougouffa, Smail

    2010-01-01

    We investigate the phenomenon of sudden death of entanglement in a high-dimensional bipartite system subjected to dissipative environments with an arbitrary initial pure entangled state between two fields in the cavities. We find that in a vacuum reservoir, the presence of the state where one or more than one (two) photons in each cavity are present is a necessary condition for the sudden death of entanglement. Otherwise entanglement remains for infinite time and decays asymptotically with the decay of individual qubits. For pure two-qubit entangled states in a thermal environment, we observe that sudden death of entanglement always occurs. The sudden death time of the entangled states is related to the number of photons in the cavities, the temperature of the reservoir and the initial preparation of the entangled states.

  10. Time–energy high-dimensional one-side device-independent quantum key distribution

    International Nuclear Information System (INIS)

    Bao Hai-Ze; Bao Wan-Su; Wang Yang; Chen Rui-Ke; Ma Hong-Xin; Zhou Chun; Li Hong-Wei

    2017-01-01

    Compared with full device-independent quantum key distribution (DI-QKD), one-side device-independent QKD (1sDI-QKD) needs fewer requirements, which is much easier to meet. In this paper, by applying recently developed novel time–energy entropic uncertainty relations, we present a time–energy high-dimensional one-side device-independent quantum key distribution (HD-QKD) and provide the security proof against coherent attacks. Besides, we connect the security with the quantum steering. By numerical simulation, we obtain the secret key rate for Alice’s different detection efficiencies. The results show that our protocol can performance much better than the original 1sDI-QKD. Furthermore, we clarify the relation among the secret key rate, Alice’s detection efficiency, and the dispersion coefficient. Finally, we simply analyze its performance in the optical fiber channel. (paper)

  11. A Cure for Variance Inflation in High Dimensional Kernel Principal Component Analysis

    DEFF Research Database (Denmark)

    Abrahamsen, Trine Julie; Hansen, Lars Kai

    2011-01-01

    Small sample high-dimensional principal component analysis (PCA) suffers from variance inflation and lack of generalizability. It has earlier been pointed out that a simple leave-one-out variance renormalization scheme can cure the problem. In this paper we generalize the cure in two directions......: First, we propose a computationally less intensive approximate leave-one-out estimator, secondly, we show that variance inflation is also present in kernel principal component analysis (kPCA) and we provide a non-parametric renormalization scheme which can quite efficiently restore generalizability in kPCA....... As for PCA our analysis also suggests a simplified approximate expression. © 2011 Trine J. Abrahamsen and Lars K. Hansen....

  12. Inference for feature selection using the Lasso with high-dimensional data

    DEFF Research Database (Denmark)

    Brink-Jensen, Kasper; Ekstrøm, Claus Thorn

    2014-01-01

    Penalized regression models such as the Lasso have proved useful for variable selection in many fields - especially for situations with high-dimensional data where the numbers of predictors far exceeds the number of observations. These methods identify and rank variables of importance but do...... not generally provide any inference of the selected variables. Thus, the variables selected might be the "most important" but need not be significant. We propose a significance test for the selection found by the Lasso. We introduce a procedure that computes inference and p-values for features chosen...... by the Lasso. This method rephrases the null hypothesis and uses a randomization approach which ensures that the error rate is controlled even for small samples. We demonstrate the ability of the algorithm to compute $p$-values of the expected magnitude with simulated data using a multitude of scenarios...

  13. Diagonal Likelihood Ratio Test for Equality of Mean Vectors in High-Dimensional Data

    KAUST Repository

    Hu, Zongliang; Tong, Tiejun; Genton, Marc G.

    2017-01-01

    We propose a likelihood ratio test framework for testing normal mean vectors in high-dimensional data under two common scenarios: the one-sample test and the two-sample test with equal covariance matrices. We derive the test statistics under the assumption that the covariance matrices follow a diagonal matrix structure. In comparison with the diagonal Hotelling's tests, our proposed test statistics display some interesting characteristics. In particular, they are a summation of the log-transformed squared t-statistics rather than a direct summation of those components. More importantly, to derive the asymptotic normality of our test statistics under the null and local alternative hypotheses, we do not require the assumption that the covariance matrix follows a diagonal matrix structure. As a consequence, our proposed test methods are very flexible and can be widely applied in practice. Finally, simulation studies and a real data analysis are also conducted to demonstrate the advantages of our likelihood ratio test method.

  14. Characterization of differentially expressed genes using high-dimensional co-expression networks

    DEFF Research Database (Denmark)

    Coelho Goncalves de Abreu, Gabriel; Labouriau, Rodrigo S.

    2010-01-01

    We present a technique to characterize differentially expressed genes in terms of their position in a high-dimensional co-expression network. The set-up of Gaussian graphical models is used to construct representations of the co-expression network in such a way that redundancy and the propagation...... that allow to make effective inference in problems with high degree of complexity (e.g. several thousands of genes) and small number of observations (e.g. 10-100) as typically occurs in high throughput gene expression studies. Taking advantage of the internal structure of decomposable graphical models, we...... construct a compact representation of the co-expression network that allows to identify the regions with high concentration of differentially expressed genes. It is argued that differentially expressed genes located in highly interconnected regions of the co-expression network are less informative than...

  15. Kernel based methods for accelerated failure time model with ultra-high dimensional data

    Directory of Open Access Journals (Sweden)

    Jiang Feng

    2010-12-01

    Full Text Available Abstract Background Most genomic data have ultra-high dimensions with more than 10,000 genes (probes. Regularization methods with L1 and Lp penalty have been extensively studied in survival analysis with high-dimensional genomic data. However, when the sample size n ≪ m (the number of genes, directly identifying a small subset of genes from ultra-high (m > 10, 000 dimensional data is time-consuming and not computationally efficient. In current microarray analysis, what people really do is select a couple of thousands (or hundreds of genes using univariate analysis or statistical tests, and then apply the LASSO-type penalty to further reduce the number of disease associated genes. This two-step procedure may introduce bias and inaccuracy and lead us to miss biologically important genes. Results The accelerated failure time (AFT model is a linear regression model and a useful alternative to the Cox model for survival analysis. In this paper, we propose a nonlinear kernel based AFT model and an efficient variable selection method with adaptive kernel ridge regression. Our proposed variable selection method is based on the kernel matrix and dual problem with a much smaller n × n matrix. It is very efficient when the number of unknown variables (genes is much larger than the number of samples. Moreover, the primal variables are explicitly updated and the sparsity in the solution is exploited. Conclusions Our proposed methods can simultaneously identify survival associated prognostic factors and predict survival outcomes with ultra-high dimensional genomic data. We have demonstrated the performance of our methods with both simulation and real data. The proposed method performs superbly with limited computational studies.

  16. Joint Adaptive Mean-Variance Regularization and Variance Stabilization of High Dimensional Data.

    Science.gov (United States)

    Dazard, Jean-Eudes; Rao, J Sunil

    2012-07-01

    The paper addresses a common problem in the analysis of high-dimensional high-throughput "omics" data, which is parameter estimation across multiple variables in a set of data where the number of variables is much larger than the sample size. Among the problems posed by this type of data are that variable-specific estimators of variances are not reliable and variable-wise tests statistics have low power, both due to a lack of degrees of freedom. In addition, it has been observed in this type of data that the variance increases as a function of the mean. We introduce a non-parametric adaptive regularization procedure that is innovative in that : (i) it employs a novel "similarity statistic"-based clustering technique to generate local-pooled or regularized shrinkage estimators of population parameters, (ii) the regularization is done jointly on population moments, benefiting from C. Stein's result on inadmissibility, which implies that usual sample variance estimator is improved by a shrinkage estimator using information contained in the sample mean. From these joint regularized shrinkage estimators, we derived regularized t-like statistics and show in simulation studies that they offer more statistical power in hypothesis testing than their standard sample counterparts, or regular common value-shrinkage estimators, or when the information contained in the sample mean is simply ignored. Finally, we show that these estimators feature interesting properties of variance stabilization and normalization that can be used for preprocessing high-dimensional multivariate data. The method is available as an R package, called 'MVR' ('Mean-Variance Regularization'), downloadable from the CRAN website.

  17. Input and Intake in Language Acquisition

    Science.gov (United States)

    Gagliardi, Ann C.

    2012-01-01

    This dissertation presents an approach for a productive way forward in the study of language acquisition, sealing the rift between claims of an innate linguistic hypothesis space and powerful domain general statistical inference. This approach breaks language acquisition into its component parts, distinguishing the input in the environment from…

  18. FLUTAN input specifications

    International Nuclear Information System (INIS)

    Borgwaldt, H.; Baumann, W.; Willerding, G.

    1991-05-01

    FLUTAN is a highly vectorized computer code for 3-D fluiddynamic and thermal-hydraulic analyses in cartesian and cylinder coordinates. It is related to the family of COMMIX codes originally developed at Argonne National Laboratory, USA. To a large extent, FLUTAN relies on basic concepts and structures imported from COMMIX-1B and COMMIX-2 which were made available to KfK in the frame of cooperation contracts in the fast reactor safety field. While on the one hand not all features of the original COMMIX versions have been implemented in FLUTAN, the code on the other hand includes some essential innovative options like CRESOR solution algorithm, general 3-dimensional rebalacing scheme for solving the pressure equation, and LECUSSO-QUICK-FRAM techniques suitable for reducing 'numerical diffusion' in both the enthalphy and momentum equations. This report provides users with detailed input instructions, presents formulations of the various model options, and explains by means of comprehensive sample input, how to use the code. (orig.) [de

  19. GARFEM input deck description

    Energy Technology Data Exchange (ETDEWEB)

    Zdunek, A.; Soederberg, M. (Aeronautical Research Inst. of Sweden, Bromma (Sweden))

    1989-01-01

    The input card deck for the finite element program GARFEM version 3.2 is described in this manual. The program includes, but is not limited to, capabilities to handle the following problems: * Linear bar and beam element structures, * Geometrically non-linear problems (bar and beam), both static and transient dynamic analysis, * Transient response dynamics from a catalog of time varying external forcing function types or input function tables, * Eigenvalue solution (modes and frequencies), * Multi point constraints (MPC) for the modelling of mechanisms and e.g. rigid links. The MPC definition is used only in the geometrically linearized sense, * Beams with disjunct shear axis and neutral axis, * Beams with rigid offset. An interface exist that connects GARFEM with the program GAROS. GAROS is a program for aeroelastic analysis of rotating structures. Since this interface was developed GARFEM now serves as a preprocessor program in place of NASTRAN which was formerly used. Documentation of the methods applied in GARFEM exists but is so far limited to the capacities in existence before the GAROS interface was developed.

  20. Input or intimacy

    Directory of Open Access Journals (Sweden)

    Judit Navracsics

    2014-01-01

    Full Text Available According to the critical period hypothesis, the earlier the acquisition of a second language starts, the better. Owing to the plasticity of the brain, up until a certain age a second language can be acquired successfully according to this view. Early second language learners are commonly said to have an advantage over later ones especially in phonetic/phonological acquisition. Native-like pronunciation is said to be most likely to be achieved by young learners. However, there is evidence of accentfree speech in second languages learnt after puberty as well. Occasionally, on the other hand, a nonnative accent may appear even in early second (or third language acquisition. Cross-linguistic influences are natural in multilingual development, and we would expect the dominant language to have an impact on the weaker one(s. The dominant language is usually the one that provides the largest amount of input for the child. But is it always the amount that counts? Perhaps sometimes other factors, such as emotions, ome into play? In this paper, data obtained from an EnglishPersian-Hungarian trilingual pair of siblings (under age 4 and 3 respectively is analyzed, with a special focus on cross-linguistic influences at the phonetic/phonological levels. It will be shown that beyond the amount of input there are more important factors that trigger interference in multilingual development.

  1. Bayesian screening for active compounds in high-dimensional chemical spaces combining property descriptors and molecular fingerprints.

    Science.gov (United States)

    Vogt, Martin; Bajorath, Jürgen

    2008-01-01

    Bayesian classifiers are increasingly being used to distinguish active from inactive compounds and search large databases for novel active molecules. We introduce an approach to directly combine the contributions of property descriptors and molecular fingerprints in the search for active compounds that is based on a Bayesian framework. Conventionally, property descriptors and fingerprints are used as alternative features for virtual screening methods. Following the approach introduced here, probability distributions of descriptor values and fingerprint bit settings are calculated for active and database molecules and the divergence between the resulting combined distributions is determined as a measure of biological activity. In test calculations on a large number of compound activity classes, this methodology was found to consistently perform better than similarity searching using fingerprints and multiple reference compounds or Bayesian screening calculations using probability distributions calculated only from property descriptors. These findings demonstrate that there is considerable synergy between different types of property descriptors and fingerprints in recognizing diverse structure-activity relationships, at least in the context of Bayesian modeling.

  2. A Near-linear Time Approximation Algorithm for Angle-based Outlier Detection in High-dimensional Data

    DEFF Research Database (Denmark)

    Pham, Ninh Dang; Pagh, Rasmus

    2012-01-01

    projection-based technique that is able to estimate the angle-based outlier factor for all data points in time near-linear in the size of the data. Also, our approach is suitable to be performed in parallel environment to achieve a parallel speedup. We introduce a theoretical analysis of the quality...... neighbor are deteriorated in high-dimensional data. Following up on the work of Kriegel et al. (KDD '08), we investigate the use of angle-based outlier factor in mining high-dimensional outliers. While their algorithm runs in cubic time (with a quadratic time heuristic), we propose a novel random......Outlier mining in d-dimensional point sets is a fundamental and well studied data mining task due to its variety of applications. Most such applications arise in high-dimensional domains. A bottleneck of existing approaches is that implicit or explicit assessments on concepts of distance or nearest...

  3. Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data.

    Science.gov (United States)

    Becker, Natalia; Toedt, Grischa; Lichter, Peter; Benner, Axel

    2011-05-09

    Classification and variable selection play an important role in knowledge discovery in high-dimensional data. Although Support Vector Machine (SVM) algorithms are among the most powerful classification and prediction methods with a wide range of scientific applications, the SVM does not include automatic feature selection and therefore a number of feature selection procedures have been developed. Regularisation approaches extend SVM to a feature selection method in a flexible way using penalty functions like LASSO, SCAD and Elastic Net.We propose a novel penalty function for SVM classification tasks, Elastic SCAD, a combination of SCAD and ridge penalties which overcomes the limitations of each penalty alone.Since SVM models are extremely sensitive to the choice of tuning parameters, we adopted an interval search algorithm, which in comparison to a fixed grid search finds rapidly and more precisely a global optimal solution. Feature selection methods with combined penalties (Elastic Net and Elastic SCAD SVMs) are more robust to a change of the model complexity than methods using single penalties. Our simulation study showed that Elastic SCAD SVM outperformed LASSO (L1) and SCAD SVMs. Moreover, Elastic SCAD SVM provided sparser classifiers in terms of median number of features selected than Elastic Net SVM and often better predicted than Elastic Net in terms of misclassification error.Finally, we applied the penalization methods described above on four publicly available breast cancer data sets. Elastic SCAD SVM was the only method providing robust classifiers in sparse and non-sparse situations. The proposed Elastic SCAD SVM algorithm provides the advantages of the SCAD penalty and at the same time avoids sparsity limitations for non-sparse data. We were first to demonstrate that the integration of the interval search algorithm and penalized SVM classification techniques provides fast solutions on the optimization of tuning parameters.The penalized SVM

  4. Load Estimation from Natural input Modal Analysis

    DEFF Research Database (Denmark)

    Aenlle, Manuel López; Brincker, Rune; Canteli, Alfonso Fernández

    2005-01-01

    One application of Natural Input Modal Analysis consists in estimating the unknown load acting on structures such as wind loads, wave loads, traffic loads, etc. In this paper, a procedure to determine loading from a truncated modal model, as well as the results of an experimental testing programme...... estimation. In the experimental program a small structure subjected to vibration was used to estimate the loading from the measurements and the experimental modal space. The modal parameters were estimated by Natural Input Modal Analysis and the scaling factors of the mode shapes obtained by the mass change...

  5. GAROS input deck description

    Energy Technology Data Exchange (ETDEWEB)

    Vollan, A.; Soederberg, M. (Aeronautical Research Inst. of Sweden, Bromma (Sweden))

    1989-01-01

    This report describes the input for the programs GAROS1 and GAROS2, version 5.8 and later, February 1988. The GAROS system, developed by Arne Vollan, Omega GmbH, is used for the analysis of the mechanical and aeroelastic properties for general rotating systems. It has been specially designed to meet the requirements of aeroelastic stability and dynamic response of horizontal axis wind energy converters. Some of the special characteristics are: * The rotor may have one or more blades. * The blades may be rigidly attached to the hub, or they may be fully articulated. * The full elastic properties of the blades, the hub, the machine house and the tower are taken into account. * With the same basic model, a number of different analyses can be performed: Snap-shot analysis, Floquet method, transient response analysis, frequency response analysis etc.

  6. Access to Research Inputs

    DEFF Research Database (Denmark)

    Czarnitzki, Dirk; Grimpe, Christoph; Pellens, Maikel

    2015-01-01

    The viability of modern open science norms and practices depends on public disclosure of new knowledge, methods, and materials. However, increasing industry funding of research can restrict the dissemination of results and materials. We show, through a survey sample of 837 German scientists in life...... sciences, natural sciences, engineering, and social sciences, that scientists who receive industry funding are twice as likely to deny requests for research inputs as those who do not. Receiving external funding in general does not affect denying others access. Scientists who receive external funding...... of any kind are, however, 50 % more likely to be denied access to research materials by others, but this is not affected by being funded specifically by industry...

  7. Access to Research Inputs

    DEFF Research Database (Denmark)

    Czarnitzki, Dirk; Grimpe, Christoph; Pellens, Maikel

    The viability of modern open science norms and practices depend on public disclosure of new knowledge, methods, and materials. However, increasing industry funding of research can restrict the dissemination of results and materials. We show, through a survey sample of 837 German scientists in life...... sciences, natural sciences, engineering, and social sciences, that scientists who receive industry funding are twice as likely to deny requests for research inputs as those who do not. Receiving external funding in general does not affect denying others access. Scientists who receive external funding...... of any kind are, however, 50% more likely to be denied access to research materials by others, but this is not affected by being funded specifically by industry....

  8. Prediction-Oriented Marker Selection (PROMISE): With Application to High-Dimensional Regression.

    Science.gov (United States)

    Kim, Soyeon; Baladandayuthapani, Veerabhadran; Lee, J Jack

    2017-06-01

    In personalized medicine, biomarkers are used to select therapies with the highest likelihood of success based on an individual patient's biomarker/genomic profile. Two goals are to choose important biomarkers that accurately predict treatment outcomes and to cull unimportant biomarkers to reduce the cost of biological and clinical verifications. These goals are challenging due to the high dimensionality of genomic data. Variable selection methods based on penalized regression (e.g., the lasso and elastic net) have yielded promising results. However, selecting the right amount of penalization is critical to simultaneously achieving these two goals. Standard approaches based on cross-validation (CV) typically provide high prediction accuracy with high true positive rates but at the cost of too many false positives. Alternatively, stability selection (SS) controls the number of false positives, but at the cost of yielding too few true positives. To circumvent these issues, we propose prediction-oriented marker selection (PROMISE), which combines SS with CV to conflate the advantages of both methods. Our application of PROMISE with the lasso and elastic net in data analysis shows that, compared to CV, PROMISE produces sparse solutions, few false positives, and small type I + type II error, and maintains good prediction accuracy, with a marginal decrease in the true positive rates. Compared to SS, PROMISE offers better prediction accuracy and true positive rates. In summary, PROMISE can be applied in many fields to select regularization parameters when the goals are to minimize false positives and maximize prediction accuracy.

  9. Diagonal Likelihood Ratio Test for Equality of Mean Vectors in High-Dimensional Data

    KAUST Repository

    Hu, Zongliang

    2017-10-27

    We propose a likelihood ratio test framework for testing normal mean vectors in high-dimensional data under two common scenarios: the one-sample test and the two-sample test with equal covariance matrices. We derive the test statistics under the assumption that the covariance matrices follow a diagonal matrix structure. In comparison with the diagonal Hotelling\\'s tests, our proposed test statistics display some interesting characteristics. In particular, they are a summation of the log-transformed squared t-statistics rather than a direct summation of those components. More importantly, to derive the asymptotic normality of our test statistics under the null and local alternative hypotheses, we do not require the assumption that the covariance matrix follows a diagonal matrix structure. As a consequence, our proposed test methods are very flexible and can be widely applied in practice. Finally, simulation studies and a real data analysis are also conducted to demonstrate the advantages of our likelihood ratio test method.

  10. Technical Report: Toward a Scalable Algorithm to Compute High-Dimensional Integrals of Arbitrary Functions

    International Nuclear Information System (INIS)

    Snyder, Abigail C.; Jiao, Yu

    2010-01-01

    Neutron experiments at the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) frequently generate large amounts of data (on the order of 106-1012 data points). Hence, traditional data analysis tools run on a single CPU take too long to be practical and scientists are unable to efficiently analyze all data generated by experiments. Our goal is to develop a scalable algorithm to efficiently compute high-dimensional integrals of arbitrary functions. This algorithm can then be used to integrate the four-dimensional integrals that arise as part of modeling intensity from the experiments at the SNS. Here, three different one-dimensional numerical integration solvers from the GNU Scientific Library were modified and implemented to solve four-dimensional integrals. The results of these solvers on a final integrand provided by scientists at the SNS can be compared to the results of other methods, such as quasi-Monte Carlo methods, computing the same integral. A parallelized version of the most efficient method can allow scientists the opportunity to more effectively analyze all experimental data.

  11. Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires

    Directory of Open Access Journals (Sweden)

    Enkelejda Miho

    2018-02-01

    Full Text Available The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV. Adaptive immune receptor repertoire sequencing (AIRR-seq has driven the quantitative and molecular-level profiling of immune repertoires, thereby revealing the high-dimensional complexity of the immune receptor sequence landscape. Several methods for the computational and statistical analysis of large-scale AIRR-seq data have been developed to resolve immune repertoire complexity and to understand the dynamics of adaptive immunity. Here, we review the current research on (i diversity, (ii clustering and network, (iii phylogenetic, and (iv machine learning methods applied to dissect, quantify, and compare the architecture, evolution, and specificity of immune repertoires. We summarize outstanding questions in computational immunology and propose future directions for systems immunology toward coupling AIRR-seq with the computational discovery of immunotherapeutics, vaccines, and immunodiagnostics.

  12. Construction of high-dimensional neural network potentials using environment-dependent atom pairs.

    Science.gov (United States)

    Jose, K V Jovan; Artrith, Nongnuch; Behler, Jörg

    2012-05-21

    An accurate determination of the potential energy is the crucial step in computer simulations of chemical processes, but using electronic structure methods on-the-fly in molecular dynamics (MD) is computationally too demanding for many systems. Constructing more efficient interatomic potentials becomes intricate with increasing dimensionality of the potential-energy surface (PES), and for numerous systems the accuracy that can be achieved is still not satisfying and far from the reliability of first-principles calculations. Feed-forward neural networks (NNs) have a very flexible functional form, and in recent years they have been shown to be an accurate tool to construct efficient PESs. High-dimensional NN potentials based on environment-dependent atomic energy contributions have been presented for a number of materials. Still, these potentials may be improved by a more detailed structural description, e.g., in form of atom pairs, which directly reflect the atomic interactions and take the chemical environment into account. We present an implementation of an NN method based on atom pairs, and its accuracy and performance are compared to the atom-based NN approach using two very different systems, the methanol molecule and metallic copper. We find that both types of NN potentials provide an excellent description of both PESs, with the pair-based method yielding a slightly higher accuracy making it a competitive alternative for addressing complex systems in MD simulations.

  13. Two-Sample Tests for High-Dimensional Linear Regression with an Application to Detecting Interactions.

    Science.gov (United States)

    Xia, Yin; Cai, Tianxi; Cai, T Tony

    2018-01-01

    Motivated by applications in genomics, we consider in this paper global and multiple testing for the comparisons of two high-dimensional linear regression models. A procedure for testing the equality of the two regression vectors globally is proposed and shown to be particularly powerful against sparse alternatives. We then introduce a multiple testing procedure for identifying unequal coordinates while controlling the false discovery rate and false discovery proportion. Theoretical justifications are provided to guarantee the validity of the proposed tests and optimality results are established under sparsity assumptions on the regression coefficients. The proposed testing procedures are easy to implement. Numerical properties of the procedures are investigated through simulation and data analysis. The results show that the proposed tests maintain the desired error rates under the null and have good power under the alternative at moderate sample sizes. The procedures are applied to the Framingham Offspring study to investigate the interactions between smoking and cardiovascular related genetic mutations important for an inflammation marker.

  14. A Comparison of Machine Learning Methods in a High-Dimensional Classification Problem

    Directory of Open Access Journals (Sweden)

    Zekić-Sušac Marijana

    2014-09-01

    Full Text Available Background: Large-dimensional data modelling often relies on variable reduction methods in the pre-processing and in the post-processing stage. However, such a reduction usually provides less information and yields a lower accuracy of the model. Objectives: The aim of this paper is to assess the high-dimensional classification problem of recognizing entrepreneurial intentions of students by machine learning methods. Methods/Approach: Four methods were tested: artificial neural networks, CART classification trees, support vector machines, and k-nearest neighbour on the same dataset in order to compare their efficiency in the sense of classification accuracy. The performance of each method was compared on ten subsamples in a 10-fold cross-validation procedure in order to assess computing sensitivity and specificity of each model. Results: The artificial neural network model based on multilayer perceptron yielded a higher classification rate than the models produced by other methods. The pairwise t-test showed a statistical significance between the artificial neural network and the k-nearest neighbour model, while the difference among other methods was not statistically significant. Conclusions: Tested machine learning methods are able to learn fast and achieve high classification accuracy. However, further advancement can be assured by testing a few additional methodological refinements in machine learning methods.

  15. High-dimensional neural network potentials for solvation: The case of protonated water clusters in helium

    Science.gov (United States)

    Schran, Christoph; Uhl, Felix; Behler, Jörg; Marx, Dominik

    2018-03-01

    The design of accurate helium-solute interaction potentials for the simulation of chemically complex molecules solvated in superfluid helium has long been a cumbersome task due to the rather weak but strongly anisotropic nature of the interactions. We show that this challenge can be met by using a combination of an effective pair potential for the He-He interactions and a flexible high-dimensional neural network potential (NNP) for describing the complex interaction between helium and the solute in a pairwise additive manner. This approach yields an excellent agreement with a mean absolute deviation as small as 0.04 kJ mol-1 for the interaction energy between helium and both hydronium and Zundel cations compared with coupled cluster reference calculations with an energetically converged basis set. The construction and improvement of the potential can be performed in a highly automated way, which opens the door for applications to a variety of reactive molecules to study the effect of solvation on the solute as well as the solute-induced structuring of the solvent. Furthermore, we show that this NNP approach yields very convincing agreement with the coupled cluster reference for properties like many-body spatial and radial distribution functions. This holds for the microsolvation of the protonated water monomer and dimer by a few helium atoms up to their solvation in bulk helium as obtained from path integral simulations at about 1 K.

  16. Multi-Scale Factor Analysis of High-Dimensional Brain Signals

    KAUST Repository

    Ting, Chee-Ming

    2017-05-18

    In this paper, we develop an approach to modeling high-dimensional networks with a large number of nodes arranged in a hierarchical and modular structure. We propose a novel multi-scale factor analysis (MSFA) model which partitions the massive spatio-temporal data defined over the complex networks into a finite set of regional clusters. To achieve further dimension reduction, we represent the signals in each cluster by a small number of latent factors. The correlation matrix for all nodes in the network are approximated by lower-dimensional sub-structures derived from the cluster-specific factors. To estimate regional connectivity between numerous nodes (within each cluster), we apply principal components analysis (PCA) to produce factors which are derived as the optimal reconstruction of the observed signals under the squared loss. Then, we estimate global connectivity (between clusters or sub-networks) based on the factors across regions using the RV-coefficient as the cross-dependence measure. This gives a reliable and computationally efficient multi-scale analysis of both regional and global dependencies of the large networks. The proposed novel approach is applied to estimate brain connectivity networks using functional magnetic resonance imaging (fMRI) data. Results on resting-state fMRI reveal interesting modular and hierarchical organization of human brain networks during rest.

  17. Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and "hidden" dimensions.

    Science.gov (United States)

    Meng, Xi; Nguyen, Bao D; Ridge, Clark; Shaka, A J

    2009-01-01

    High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to "reduced-dimensionality" strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the filter diagonalization method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra-dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths.

  18. Simulation-based hypothesis testing of high dimensional means under covariance heterogeneity.

    Science.gov (United States)

    Chang, Jinyuan; Zheng, Chao; Zhou, Wen-Xin; Zhou, Wen

    2017-12-01

    In this article, we study the problem of testing the mean vectors of high dimensional data in both one-sample and two-sample cases. The proposed testing procedures employ maximum-type statistics and the parametric bootstrap techniques to compute the critical values. Different from the existing tests that heavily rely on the structural conditions on the unknown covariance matrices, the proposed tests allow general covariance structures of the data and therefore enjoy wide scope of applicability in practice. To enhance powers of the tests against sparse alternatives, we further propose two-step procedures with a preliminary feature screening step. Theoretical properties of the proposed tests are investigated. Through extensive numerical experiments on synthetic data sets and an human acute lymphoblastic leukemia gene expression data set, we illustrate the performance of the new tests and how they may provide assistance on detecting disease-associated gene-sets. The proposed methods have been implemented in an R-package HDtest and are available on CRAN. © 2017, The International Biometric Society.

  19. Multi-SOM: an Algorithm for High-Dimensional, Small Size Datasets

    Directory of Open Access Journals (Sweden)

    Shen Lu

    2013-04-01

    Full Text Available Since it takes time to do experiments in bioinformatics, biological datasets are sometimes small but with high dimensionality. From probability theory, in order to discover knowledge from a set of data, we have to have a sufficient number of samples. Otherwise, the error bounds can become too large to be useful. For the SOM (Self- Organizing Map algorithm, the initial map is based on the training data. In order to avoid the bias caused by the insufficient training data, in this paper we present an algorithm, called Multi-SOM. Multi-SOM builds a number of small self-organizing maps, instead of just one big map. Bayesian decision theory is used to make the final decision among similar neurons on different maps. In this way, we can better ensure that we can get a real random initial weight vector set, the map size is less of consideration and errors tend to average out. In our experiments as applied to microarray datasets which are highly intense data composed of genetic related information, the precision of Multi-SOMs is 10.58% greater than SOMs, and its recall is 11.07% greater than SOMs. Thus, the Multi-SOMs algorithm is practical.

  20. Modeling and simulation of high dimensional stochastic multiscale PDE systems at the exascale

    Energy Technology Data Exchange (ETDEWEB)

    Zabaras, Nicolas J. [Cornell Univ., Ithaca, NY (United States)

    2016-11-08

    Predictive Modeling of multiscale and Multiphysics systems requires accurate data driven characterization of the input uncertainties, and understanding of how they propagate across scales and alter the final solution. This project develops a rigorous mathematical framework and scalable uncertainty quantification algorithms to efficiently construct realistic low dimensional input models, and surrogate low complexity systems for the analysis, design, and control of physical systems represented by multiscale stochastic PDEs. The work can be applied to many areas including physical and biological processes, from climate modeling to systems biology.

  1. Modeling and generating input processes

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, M.E.

    1987-01-01

    This tutorial paper provides information relevant to the selection and generation of stochastic inputs to simulation studies. The primary area considered is multivariate but much of the philosophy at least is relevant to univariate inputs as well. 14 refs.

  2. HDclassif : An R Package for Model-Based Clustering and Discriminant Analysis of High-Dimensional Data

    Directory of Open Access Journals (Sweden)

    Laurent Berge

    2012-01-01

    Full Text Available This paper presents the R package HDclassif which is devoted to the clustering and the discriminant analysis of high-dimensional data. The classification methods proposed in the package result from a new parametrization of the Gaussian mixture model which combines the idea of dimension reduction and model constraints on the covariance matrices. The supervised classification method using this parametrization is called high dimensional discriminant analysis (HDDA. In a similar manner, the associated clustering method iscalled high dimensional data clustering (HDDC and uses the expectation-maximization algorithm for inference. In order to correctly t the data, both methods estimate the specific subspace and the intrinsic dimension of the groups. Due to the constraints on the covariance matrices, the number of parameters to estimate is significantly lower than other model-based methods and this allows the methods to be stable and efficient in high dimensions. Two introductory examples illustrated with R codes allow the user to discover the hdda and hddc functions. Experiments on simulated and real datasets also compare HDDC and HDDA with existing classification methods on high-dimensional datasets. HDclassif is a free software and distributed under the general public license, as part of the R software project.

  3. Reprocessing input data validation

    International Nuclear Information System (INIS)

    Persiani, P.J.; Bucher, R.G.; Pond, R.B.; Cornella, R.J.

    1990-01-01

    The Isotope Correlation Technique (ICT), in conjunction with the gravimetric (Pu/U ratio) method for mass determination, provides an independent verification of the input accountancy at the dissolver or accountancy stage of the reprocessing plant. The Isotope Correlation Technique has been applied to many classes of domestic and international reactor systems (light-water, heavy-water, graphite, and liquid-metal) operating in a variety of modes (power, research, production, and breeder), and for a variety of reprocessing fuel cycle management strategies. Analysis of reprocessing operations data based on isotopic correlations derived for assemblies in a PWR environment and fuel management scheme, yielded differences between the measurement-derived and ICT-derived plutonium mass determinations of (-0.02 ± 0.23)% for the measured U-235 and (+0.50 ± 0.31)% for the measured Pu-239, for a core campaign. The ICT analyses has been implemented for the plutonium isotopics in a depleted uranium assembly in a heavy-water, enriched uranium system and for the uranium isotopes in the fuel assemblies in light-water, highly-enriched systems. 7 refs., 5 figs., 4 tabs

  4. Probabilistic numerical methods for high-dimensional stochastic control and valuation problems on electricity markets

    International Nuclear Information System (INIS)

    Langrene, Nicolas

    2014-01-01

    This thesis deals with the numerical solution of general stochastic control problems, with notable applications for electricity markets. We first propose a structural model for the price of electricity, allowing for price spikes well above the marginal fuel price under strained market conditions. This model allows to price and partially hedge electricity derivatives, using fuel forwards as hedging instruments. Then, we propose an algorithm, which combines Monte-Carlo simulations with local basis regressions, to solve general optimal switching problems. A comprehensive rate of convergence of the method is provided. Moreover, we manage to make the algorithm parsimonious in memory (and hence suitable for high dimensional problems) by generalizing to this framework a memory reduction method that avoids the storage of the sample paths. We illustrate this on the problem of investments in new power plants (our structural power price model allowing the new plants to impact the price of electricity). Finally, we study more general stochastic control problems (the control can be continuous and impact the drift and volatility of the state process), the solutions of which belong to the class of fully nonlinear Hamilton-Jacobi-Bellman equations, and can be handled via constrained Backward Stochastic Differential Equations, for which we develop a backward algorithm based on control randomization and parametric optimizations. A rate of convergence between the constraPned BSDE and its discrete version is provided, as well as an estimate of the optimal control. This algorithm is then applied to the problem of super replication of options under uncertain volatilities (and correlations). (author)

  5. Multivariate linear regression of high-dimensional fMRI data with multiple target variables.

    Science.gov (United States)

    Valente, Giancarlo; Castellanos, Agustin Lage; Vanacore, Gianluca; Formisano, Elia

    2014-05-01

    Multivariate regression is increasingly used to study the relation between fMRI spatial activation patterns and experimental stimuli or behavioral ratings. With linear models, informative brain locations are identified by mapping the model coefficients. This is a central aspect in neuroimaging, as it provides the sought-after link between the activity of neuronal populations and subject's perception, cognition or behavior. Here, we show that mapping of informative brain locations using multivariate linear regression (MLR) may lead to incorrect conclusions and interpretations. MLR algorithms for high dimensional data are designed to deal with targets (stimuli or behavioral ratings, in fMRI) separately, and the predictive map of a model integrates information deriving from both neural activity patterns and experimental design. Not accounting explicitly for the presence of other targets whose associated activity spatially overlaps with the one of interest may lead to predictive maps of troublesome interpretation. We propose a new model that can correctly identify the spatial patterns associated with a target while achieving good generalization. For each target, the training is based on an augmented dataset, which includes all remaining targets. The estimation on such datasets produces both maps and interaction coefficients, which are then used to generalize. The proposed formulation is independent of the regression algorithm employed. We validate this model on simulated fMRI data and on a publicly available dataset. Results indicate that our method achieves high spatial sensitivity and good generalization and that it helps disentangle specific neural effects from interaction with predictive maps associated with other targets. Copyright © 2013 Wiley Periodicals, Inc.

  6. Uncertainty quantification in transcranial magnetic stimulation via high-dimensional model representation.

    Science.gov (United States)

    Gomez, Luis J; Yücel, Abdulkadir C; Hernandez-Garcia, Luis; Taylor, Stephan F; Michielssen, Eric

    2015-01-01

    A computational framework for uncertainty quantification in transcranial magnetic stimulation (TMS) is presented. The framework leverages high-dimensional model representations (HDMRs), which approximate observables (i.e., quantities of interest such as electric (E) fields induced inside targeted cortical regions) via series of iteratively constructed component functions involving only the most significant random variables (i.e., parameters that characterize the uncertainty in a TMS setup such as the position and orientation of TMS coils, as well as the size, shape, and conductivity of the head tissue). The component functions of HDMR expansions are approximated via a multielement probabilistic collocation (ME-PC) method. While approximating each component function, a quasi-static finite-difference simulator is used to compute observables at integration/collocation points dictated by the ME-PC method. The proposed framework requires far fewer simulations than traditional Monte Carlo methods for providing highly accurate statistical information (e.g., the mean and standard deviation) about the observables. The efficiency and accuracy of the proposed framework are demonstrated via its application to the statistical characterization of E-fields generated by TMS inside cortical regions of an MRI-derived realistic head model. Numerical results show that while uncertainties in tissue conductivities have negligible effects on TMS operation, variations in coil position/orientation and brain size significantly affect the induced E-fields. Our numerical results have several implications for the use of TMS during depression therapy: 1) uncertainty in the coil position and orientation may reduce the response rates of patients; 2) practitioners should favor targets on the crest of a gyrus to obtain maximal stimulation; and 3) an increasing scalp-to-cortex distance reduces the magnitude of E-fields on the surface and inside the cortex.

  7. An adaptive optimal ensemble classifier via bagging and rank aggregation with applications to high dimensional data

    Directory of Open Access Journals (Sweden)

    Datta Susmita

    2010-08-01

    Full Text Available Abstract Background Generally speaking, different classifiers tend to work well for certain types of data and conversely, it is usually not known a priori which algorithm will be optimal in any given classification application. In addition, for most classification problems, selecting the best performing classification algorithm amongst a number of competing algorithms is a difficult task for various reasons. As for example, the order of performance may depend on the performance measure employed for such a comparison. In this work, we present a novel adaptive ensemble classifier constructed by combining bagging and rank aggregation that is capable of adaptively changing its performance depending on the type of data that is being classified. The attractive feature of the proposed classifier is its multi-objective nature where the classification results can be simultaneously optimized with respect to several performance measures, for example, accuracy, sensitivity and specificity. We also show that our somewhat complex strategy has better predictive performance as judged on test samples than a more naive approach that attempts to directly identify the optimal classifier based on the training data performances of the individual classifiers. Results We illustrate the proposed method with two simulated and two real-data examples. In all cases, the ensemble classifier performs at the level of the best individual classifier comprising the ensemble or better. Conclusions For complex high-dimensional datasets resulting from present day high-throughput experiments, it may be wise to consider a number of classification algorithms combined with dimension reduction techniques rather than a fixed standard algorithm set a priori.

  8. Normalization of High Dimensional Genomics Data Where the Distribution of the Altered Variables Is Skewed

    Science.gov (United States)

    Landfors, Mattias; Philip, Philge; Rydén, Patrik; Stenberg, Per

    2011-01-01

    Genome-wide analysis of gene expression or protein binding patterns using different array or sequencing based technologies is now routinely performed to compare different populations, such as treatment and reference groups. It is often necessary to normalize the data obtained to remove technical variation introduced in the course of conducting experimental work, but standard normalization techniques are not capable of eliminating technical bias in cases where the distribution of the truly altered variables is skewed, i.e. when a large fraction of the variables are either positively or negatively affected by the treatment. However, several experiments are likely to generate such skewed distributions, including ChIP-chip experiments for the study of chromatin, gene expression experiments for the study of apoptosis, and SNP-studies of copy number variation in normal and tumour tissues. A preliminary study using spike-in array data established that the capacity of an experiment to identify altered variables and generate unbiased estimates of the fold change decreases as the fraction of altered variables and the skewness increases. We propose the following work-flow for analyzing high-dimensional experiments with regions of altered variables: (1) Pre-process raw data using one of the standard normalization techniques. (2) Investigate if the distribution of the altered variables is skewed. (3) If the distribution is not believed to be skewed, no additional normalization is needed. Otherwise, re-normalize the data using a novel HMM-assisted normalization procedure. (4) Perform downstream analysis. Here, ChIP-chip data and simulated data were used to evaluate the performance of the work-flow. It was found that skewed distributions can be detected by using the novel DSE-test (Detection of Skewed Experiments). Furthermore, applying the HMM-assisted normalization to experiments where the distribution of the truly altered variables is skewed results in considerably higher

  9. From Ambiguities to Insights: Query-based Comparisons of High-Dimensional Data

    Science.gov (United States)

    Kowalski, Jeanne; Talbot, Conover; Tsai, Hua L.; Prasad, Nijaguna; Umbricht, Christopher; Zeiger, Martha A.

    2007-11-01

    Genomic technologies will revolutionize drag discovery and development; that much is universally agreed upon. The high dimension of data from such technologies has challenged available data analytic methods; that much is apparent. To date, large-scale data repositories have not been utilized in ways that permit their wealth of information to be efficiently processed for knowledge, presumably due in large part to inadequate analytical tools to address numerous comparisons of high-dimensional data. In candidate gene discovery, expression comparisons are often made between two features (e.g., cancerous versus normal), such that the enumeration of outcomes is manageable. With multiple features, the setting becomes more complex, in terms of comparing expression levels of tens of thousands transcripts across hundreds of features. In this case, the number of outcomes, while enumerable, become rapidly large and unmanageable, and scientific inquiries become more abstract, such as "which one of these (compounds, stimuli, etc.) is not like the others?" We develop analytical tools that promote more extensive, efficient, and rigorous utilization of the public data resources generated by the massive support of genomic studies. Our work innovates by enabling access to such metadata with logically formulated scientific inquires that define, compare and integrate query-comparison pair relations for analysis. We demonstrate our computational tool's potential to address an outstanding biomedical informatics issue of identifying reliable molecular markers in thyroid cancer. Our proposed query-based comparison (QBC) facilitates access to and efficient utilization of metadata through logically formed inquires expressed as query-based comparisons by organizing and comparing results from biotechnologies to address applications in biomedicine.

  10. AucPR: an AUC-based approach using penalized regression for disease prediction with high-dimensional omics data.

    Science.gov (United States)

    Yu, Wenbao; Park, Taesung

    2014-01-01

    It is common to get an optimal combination of markers for disease classification and prediction when multiple markers are available. Many approaches based on the area under the receiver operating characteristic curve (AUC) have been proposed. Existing works based on AUC in a high-dimensional context depend mainly on a non-parametric, smooth approximation of AUC, with no work using a parametric AUC-based approach, for high-dimensional data. We propose an AUC-based approach using penalized regression (AucPR), which is a parametric method used for obtaining a linear combination for maximizing the AUC. To obtain the AUC maximizer in a high-dimensional context, we transform a classical parametric AUC maximizer, which is used in a low-dimensional context, into a regression framework and thus, apply the penalization regression approach directly. Two kinds of penalization, lasso and elastic net, are considered. The parametric approach can avoid some of the difficulties of a conventional non-parametric AUC-based approach, such as the lack of an appropriate concave objective function and a prudent choice of the smoothing parameter. We apply the proposed AucPR for gene selection and classification using four real microarray and synthetic data. Through numerical studies, AucPR is shown to perform better than the penalized logistic regression and the nonparametric AUC-based method, in the sense of AUC and sensitivity for a given specificity, particularly when there are many correlated genes. We propose a powerful parametric and easily-implementable linear classifier AucPR, for gene selection and disease prediction for high-dimensional data. AucPR is recommended for its good prediction performance. Beside gene expression microarray data, AucPR can be applied to other types of high-dimensional omics data, such as miRNA and protein data.

  11. Filaments of Meaning in Word Space

    OpenAIRE

    Karlgren, Jussi; Holst, Anders; Sahlgren, Magnus

    2008-01-01

    Word space models, in the sense of vector space models built on distributional data taken from texts, are used to model semantic relations between words. We argue that the high dimensionality of typical vector space models lead to unintuitive effects on modeling likeness of meaning and that the local structure of word spaces is where interesting semantic relations reside. We show that the local structure of word spaces has substantially different dimensionality and character than the global s...

  12. DataHigh: Graphical user interface for visualizing and interacting with high-dimensional neural activity

    OpenAIRE

    Cowley, Benjamin R.; Kaufman, Matthew T.; Churchland, Mark M.; Ryu, Stephen I.; Shenoy, Krishna V.; Yu, Byron M.

    2012-01-01

    The activity of tens to hundreds of neurons can be succinctly summarized by a smaller number of latent variables extracted using dimensionality reduction methods. These latent variables define a reduced-dimensional space in which we can study how population activity varies over time, across trials, and across experimental conditions. Ideally, we would like to visualize the population activity directly in the reduced-dimensional space, whose optimal dimensionality (as determined from the data)...

  13. Integrating high dimensional bi-directional parsing models for gene mention tagging.

    Science.gov (United States)

    Hsu, Chun-Nan; Chang, Yu-Ming; Kuo, Cheng-Ju; Lin, Yu-Shi; Huang, Han-Shen; Chung, I-Fang

    2008-07-01

    Tagging gene and gene product mentions in scientific text is an important initial step of literature mining. In this article, we describe in detail our gene mention tagger participated in BioCreative 2 challenge and analyze what contributes to its good performance. Our tagger is based on the conditional random fields model (CRF), the most prevailing method for the gene mention tagging task in BioCreative 2. Our tagger is interesting because it accomplished the highest F-scores among CRF-based methods and second over all. Moreover, we obtained our results by mostly applying open source packages, making it easy to duplicate our results. We first describe in detail how we developed our CRF-based tagger. We designed a very high dimensional feature set that includes most of information that may be relevant. We trained bi-directional CRF models with the same set of features, one applies forward parsing and the other backward, and integrated two models based on the output scores and dictionary filtering. One of the most prominent factors that contributes to the good performance of our tagger is the integration of an additional backward parsing model. However, from the definition of CRF, it appears that a CRF model is symmetric and bi-directional parsing models will produce the same results. We show that due to different feature settings, a CRF model can be asymmetric and the feature setting for our tagger in BioCreative 2 not only produces different results but also gives backward parsing models slight but constant advantage over forward parsing model. To fully explore the potential of integrating bi-directional parsing models, we applied different asymmetric feature settings to generate many bi-directional parsing models and integrate them based on the output scores. Experimental results show that this integrated model can achieve even higher F-score solely based on the training corpus for gene mention tagging. Data sets, programs and an on-line service of our gene

  14. Greedy algorithms for high-dimensional non-symmetric linear problems***

    Directory of Open Access Journals (Sweden)

    Cancès E.

    2013-12-01

    Full Text Available In this article, we present a family of numerical approaches to solve high-dimensional linear non-symmetric problems. The principle of these methods is to approximate a function which depends on a large number of variates by a sum of tensor product functions, each term of which is iteratively computed via a greedy algorithm ? . There exists a good theoretical framework for these methods in the case of (linear and nonlinear symmetric elliptic problems. However, the convergence results are not valid any more as soon as the problems under consideration are not symmetric. We present here a review of the main algorithms proposed in the literature to circumvent this difficulty, together with some new approaches. The theoretical convergence results and the practical implementation of these algorithms are discussed. Their behaviors are illustrated through some numerical examples. Dans cet article, nous présentons une famille de méthodes numériques pour résoudre des problèmes linéaires non symétriques en grande dimension. Le principe de ces approches est de représenter une fonction dépendant d’un grand nombre de variables sous la forme d’une somme de fonctions produit tensoriel, dont chaque terme est calculé itérativement via un algorithme glouton ? . Ces méthodes possèdent de bonnes propriétés théoriques dans le cas de problèmes elliptiques symétriques (linéaires ou non linéaires, mais celles-ci ne sont plus valables dès lors que les problèmes considérés ne sont plus symétriques. Nous présentons une revue des principaux algorithmes proposés dans la littérature pour contourner cette difficulté ainsi que de nouvelles approches que nous proposons. Les résultats de convergence théoriques et la mise en oeuvre pratique de ces algorithmes sont détaillés et leur comportement est illustré au travers d’exemples numériques.

  15. Space space space

    CERN Document Server

    Trembach, Vera

    2014-01-01

    Space is an introduction to the mysteries of the Universe. Included are Task Cards for independent learning, Journal Word Cards for creative writing, and Hands-On Activities for reinforcing skills in Math and Language Arts. Space is a perfect introduction to further research of the Solar System.

  16. Enhanced, targeted sampling of high-dimensional free-energy landscapes using variationally enhanced sampling, with an application to chignolin.

    Science.gov (United States)

    Shaffer, Patrick; Valsson, Omar; Parrinello, Michele

    2016-02-02

    The capabilities of molecular simulations have been greatly extended by a number of widely used enhanced sampling methods that facilitate escaping from metastable states and crossing large barriers. Despite these developments there are still many problems which remain out of reach for these methods which has led to a vigorous effort in this area. One of the most important problems that remains unsolved is sampling high-dimensional free-energy landscapes and systems that are not easily described by a small number of collective variables. In this work we demonstrate a new way to compute free-energy landscapes of high dimensionality based on the previously introduced variationally enhanced sampling, and we apply it to the miniprotein chignolin.

  17. Enhanced, targeted sampling of high-dimensional free-energy landscapes using variationally enhanced sampling, with an application to chignolin

    Science.gov (United States)

    Shaffer, Patrick; Valsson, Omar; Parrinello, Michele

    2016-01-01

    The capabilities of molecular simulations have been greatly extended by a number of widely used enhanced sampling methods that facilitate escaping from metastable states and crossing large barriers. Despite these developments there are still many problems which remain out of reach for these methods which has led to a vigorous effort in this area. One of the most important problems that remains unsolved is sampling high-dimensional free-energy landscapes and systems that are not easily described by a small number of collective variables. In this work we demonstrate a new way to compute free-energy landscapes of high dimensionality based on the previously introduced variationally enhanced sampling, and we apply it to the miniprotein chignolin. PMID:26787868

  18. Addressing Curse of Dimensionality in Sensitivity Analysis: How Can We Handle High-Dimensional Problems?

    Science.gov (United States)

    Safaei, S.; Haghnegahdar, A.; Razavi, S.

    2016-12-01

    Complex environmental models are now the primary tool to inform decision makers for the current or future management of environmental resources under the climate and environmental changes. These complex models often contain a large number of parameters that need to be determined by a computationally intensive calibration procedure. Sensitivity analysis (SA) is a very useful tool that not only allows for understanding the model behavior, but also helps in reducing the number of calibration parameters by identifying unimportant ones. The issue is that most global sensitivity techniques are highly computationally demanding themselves for generating robust and stable sensitivity metrics over the entire model response surface. Recently, a novel global sensitivity analysis method, Variogram Analysis of Response Surfaces (VARS), is introduced that can efficiently provide a comprehensive assessment of global sensitivity using the Variogram concept. In this work, we aim to evaluate the effectiveness of this highly efficient GSA method in saving computational burden, when applied to systems with extra-large number of input factors ( 100). We use a test function and a hydrological modelling case study to demonstrate the capability of VARS method in reducing problem dimensionality by identifying important vs unimportant input factors.

  19. Vacuum expectation values of high-dimensional operators and their contributions to the Bjorken and Ellis-Jaffe sum rules

    International Nuclear Information System (INIS)

    Oganesian, A.G.

    1998-01-01

    A method is proposed for estimating unknown vacuum expectation values of high-dimensional operators. The method is based on the idea that the factorization hypothesis is self-consistent. Results are obtained for all vacuum expectation values of dimension-7 operators, and some estimates for dimension-10 operators are presented as well. The resulting values are used to compute corrections of higher dimensions to the Bjorken and Ellis-Jaffe sum rules

  20. Pseudo inputs for pairwise learning with Gaussian processes

    DEFF Research Database (Denmark)

    Nielsen, Jens Brehm; Jensen, Bjørn Sand; Larsen, Jan

    2012-01-01

    We consider learning and prediction of pairwise comparisons between instances. The problem is motivated from a perceptual view point, where pairwise comparisons serve as an effective and extensively used paradigm. A state-of-the-art method for modeling pairwise data in high dimensional domains...... is based on a classical pairwise probit likelihood imposed with a Gaussian process prior. While extremely flexible, this non-parametric method struggles with an inconvenient O(n3) scaling in terms of the n input instances which limits the method only to smaller problems. To overcome this, we derive...... to other similar approximations that have been applied in standard Gaussian process regression and classification problems such as FI(T)C and PI(T)C....

  1. Multisymplectic Structure-Preserving in Simple Finite Element Method in High Dimensional Case

    Institute of Scientific and Technical Information of China (English)

    BAIYong-Qiang; LIUZhen; PEIMing; ZHENGZhu-Jun

    2003-01-01

    In this paper, we study a finite element scheme of some semi-linear elliptic boundary value problems in high-dhnensjonal space. With uniform mesh, we find that, the numerical scheme derived from finite element method can keep a preserved multisymplectic structure.

  2. Multisymplectic Structure-Preserving in Simple Finite Element Method in High Dimensional Case

    Institute of Scientific and Technical Information of China (English)

    BAI Yong-Qiang; LIU Zhen; PEI Ming; ZHENG Zhu-Jun

    2003-01-01

    In this paper, we study a finite element scheme of some semi-linear elliptic boundary value problems inhigh-dimensional space. With uniform mesh, we find that, the numerical scheme derived from finite element method cankeep a preserved multisymplectic structure.

  3. Restoring the Generalizability of SVM Based Decoding in High Dimensional Neuroimage Data

    DEFF Research Database (Denmark)

    Abrahamsen, Trine Julie; Hansen, Lars Kai

    2011-01-01

    Variance inflation is caused by a mismatch between linear projections of test and training data when projections are estimated on training sets smaller than the dimensionality of the feature space. We demonstrate that variance inflation can lead to an increased neuroimage decoding error rate...

  4. A Framework for the Interactive Handling of High-Dimensional Simulation Data in Complex Geometries

    KAUST Repository

    Benzina, Amal; Buse, Gerrit; Butnaru, Daniel; Murarasu, Alin; Treib, Marc; Varduhn, Vasco; Mundani, Ralf-Peter

    2013-01-01

    Flow simulations around building infrastructure models involve large scale complex geometries, which when discretized in adequate detail entail high computational cost. Moreover, tasks such as simulation insight by steering or optimization require many such costly simulations. In this paper, we illustrate the whole pipeline of an integrated solution for interactive computational steering, developed for complex flow simulation scenarios that depend on a moderate number of both geometric and physical parameters. A mesh generator takes building information model input data and outputs a valid cartesian discretization. A sparse-grids-based surrogate model—a less costly substitute for the parameterized simulation—uses precomputed data to deliver approximated simulation results at interactive rates. Furthermore, a distributed multi-display visualization environment shows building infrastructure together with flow data. The focus is set on scalability and intuitive user interaction.

  5. Enhanced Input in LCTL Pedagogy

    Directory of Open Access Journals (Sweden)

    Marilyn S. Manley

    2009-08-01

    Full Text Available Language materials for the more-commonly-taught languages (MCTLs often include visual input enhancement (Sharwood Smith 1991, 1993 which makes use of typographical cues like bolding and underlining to enhance the saliency of targeted forms. For a variety of reasons, this paper argues that the use of enhanced input, both visual and oral, is especially important as a tool for the lesscommonly-taught languages (LCTLs. As there continues to be a scarcity of teaching resources for the LCTLs, individual teachers must take it upon themselves to incorporate enhanced input into their own self-made materials. Specific examples of how to incorporate both visual and oral enhanced input into language teaching are drawn from the author’s own experiences teaching Cuzco Quechua. Additionally, survey results are presented from the author’s Fall 2010 semester Cuzco Quechua language students, supporting the use of both visual and oral enhanced input.

  6. Enhanced Input in LCTL Pedagogy

    Directory of Open Access Journals (Sweden)

    Marilyn S. Manley

    2010-08-01

    Full Text Available Language materials for the more-commonly-taught languages (MCTLs often include visual input enhancement (Sharwood Smith 1991, 1993 which makes use of typographical cues like bolding and underlining to enhance the saliency of targeted forms. For a variety of reasons, this paper argues that the use of enhanced input, both visual and oral, is especially important as a tool for the lesscommonly-taught languages (LCTLs. As there continues to be a scarcity of teaching resources for the LCTLs, individual teachers must take it upon themselves to incorporate enhanced input into their own self-made materials. Specific examples of how to incorporate both visual and oral enhanced input into language teaching are drawn from the author’s own experiences teaching Cuzco Quechua. Additionally, survey results are presented from the author’s Fall 2010 semester Cuzco Quechua language students, supporting the use of both visual and oral enhanced input.

  7. Graph Based Models for Unsupervised High Dimensional Data Clustering and Network Analysis

    Science.gov (United States)

    2015-01-01

    A. Porter and my advisor. The text is primarily written by me. Chapter 5 is a version of [46] where my contribution is all of the analytical ...inn Euclidean space, a variational method refers to using calculus of variation techniques to find the minimizer (or maximizer) of a functional (energy... geometric inter- pretation of modularity optimization contrasts with existing interpretations (e.g., probabilistic ones or in terms of the Potts model

  8. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity

    Science.gov (United States)

    Cowley, Benjamin R.; Kaufman, Matthew T.; Butler, Zachary S.; Churchland, Mark M.; Ryu, Stephen I.; Shenoy, Krishna V.; Yu, Byron M.

    2013-12-01

    Objective. Analyzing and interpreting the activity of a heterogeneous population of neurons can be challenging, especially as the number of neurons, experimental trials, and experimental conditions increases. One approach is to extract a set of latent variables that succinctly captures the prominent co-fluctuation patterns across the neural population. A key problem is that the number of latent variables needed to adequately describe the population activity is often greater than 3, thereby preventing direct visualization of the latent space. By visualizing a small number of 2-d projections of the latent space or each latent variable individually, it is easy to miss salient features of the population activity. Approach. To address this limitation, we developed a Matlab graphical user interface (called DataHigh) that allows the user to quickly and smoothly navigate through a continuum of different 2-d projections of the latent space. We also implemented a suite of additional visualization tools (including playing out population activity timecourses as a movie and displaying summary statistics, such as covariance ellipses and average timecourses) and an optional tool for performing dimensionality reduction. Main results. To demonstrate the utility and versatility of DataHigh, we used it to analyze single-trial spike count and single-trial timecourse population activity recorded using a multi-electrode array, as well as trial-averaged population activity recorded using single electrodes. Significance. DataHigh was developed to fulfil a need for visualization in exploratory neural data analysis, which can provide intuition that is critical for building scientific hypotheses and models of population activity.

  9. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity.

    Science.gov (United States)

    Cowley, Benjamin R; Kaufman, Matthew T; Butler, Zachary S; Churchland, Mark M; Ryu, Stephen I; Shenoy, Krishna V; Yu, Byron M

    2013-12-01

    Analyzing and interpreting the activity of a heterogeneous population of neurons can be challenging, especially as the number of neurons, experimental trials, and experimental conditions increases. One approach is to extract a set of latent variables that succinctly captures the prominent co-fluctuation patterns across the neural population. A key problem is that the number of latent variables needed to adequately describe the population activity is often greater than 3, thereby preventing direct visualization of the latent space. By visualizing a small number of 2-d projections of the latent space or each latent variable individually, it is easy to miss salient features of the population activity. To address this limitation, we developed a Matlab graphical user interface (called DataHigh) that allows the user to quickly and smoothly navigate through a continuum of different 2-d projections of the latent space. We also implemented a suite of additional visualization tools (including playing out population activity timecourses as a movie and displaying summary statistics, such as covariance ellipses and average timecourses) and an optional tool for performing dimensionality reduction. To demonstrate the utility and versatility of DataHigh, we used it to analyze single-trial spike count and single-trial timecourse population activity recorded using a multi-electrode array, as well as trial-averaged population activity recorded using single electrodes. DataHigh was developed to fulfil a need for visualization in exploratory neural data analysis, which can provide intuition that is critical for building scientific hypotheses and models of population activity.

  10. DataHigh: Graphical user interface for visualizing and interacting with high-dimensional neural activity

    Science.gov (United States)

    Cowley, Benjamin R.; Kaufman, Matthew T.; Butler, Zachary S.; Churchland, Mark M.; Ryu, Stephen I.; Shenoy, Krishna V.; Yu, Byron M.

    2014-01-01

    Objective Analyzing and interpreting the activity of a heterogeneous population of neurons can be challenging, especially as the number of neurons, experimental trials, and experimental conditions increases. One approach is to extract a set of latent variables that succinctly captures the prominent co-fluctuation patterns across the neural population. A key problem is that the number of latent variables needed to adequately describe the population activity is often greater than three, thereby preventing direct visualization of the latent space. By visualizing a small number of 2-d projections of the latent space or each latent variable individually, it is easy to miss salient features of the population activity. Approach To address this limitation, we developed a Matlab graphical user interface (called DataHigh) that allows the user to quickly and smoothly navigate through a continuum of different 2-d projections of the latent space. We also implemented a suite of additional visualization tools (including playing out population activity timecourses as a movie and displaying summary statistics, such as covariance ellipses and average timecourses) and an optional tool for performing dimensionality reduction. Main results To demonstrate the utility and versatility of DataHigh, we used it to analyze single-trial spike count and single-trial timecourse population activity recorded using a multi-electrode array, as well as trial-averaged population activity recorded using single electrodes. Significance DataHigh was developed to fulfill a need for visualization in exploratory neural data analysis, which can provide intuition that is critical for building scientific hypotheses and models of population activity. PMID:24216250

  11. Calculation of high-dimensional fission-fusion potential-energy surfaces in the SHE region

    International Nuclear Information System (INIS)

    Moeller, Peter; Sierk, Arnold J.; Ichikawa, Takatoshi; Iwamoto, Akira

    2004-01-01

    We calculate in a macroscopic-microscopic model fission-fusion potential-energy surfaces relevant to the analysis of heavy-ion reactions employed to form heavy-element evaporation residues. We study these multidimensional potential-energy surfaces both inside and outside the touching point.Inside the point of contact we define the potential on a multi-million-point grid in 5D deformation space where elongation, merging projectile and target spheroidal shapes, neck radius and projectile/target mass asymmetry are independent shape variables. The same deformation space and the corresponding potential-energy surface also describe the shape evolution from the nuclear ground-state to separating fragments in fission, and the fast-fission trajectories in incomplete fusion.For separated nuclei we study the macroscopic-microscopic potential energy, that is the ''collision surface'' between a spheroidally deformed target and a spheroidally deformed projectile as a function of three coordinates which are: the relative location of the projectile center-of-mass with respect to the target center-of-mass and the spheroidal deformations of the target and the projectile. We limit our study to the most favorable relative positions of target and projectile, namely that the symmetry axes of the target and projectile are collinear

  12. Material input of nuclear fuel

    International Nuclear Information System (INIS)

    Rissanen, S.; Tarjanne, R.

    2001-01-01

    The Material Input (MI) of nuclear fuel, expressed in terms of the total amount of natural material needed for manufacturing a product, is examined. The suitability of the MI method for assessing the environmental impacts of fuels is also discussed. Material input is expressed as a Material Input Coefficient (MIC), equalling to the total mass of natural material divided by the mass of the completed product. The material input coefficient is, however, only an intermediate result, which should not be used as such for the comparison of different fuels, because the energy contents of nuclear fuel is about 100 000-fold compared to the energy contents of fossil fuels. As a final result, the material input is expressed in proportion to the amount of generated electricity, which is called MIPS (Material Input Per Service unit). Material input is a simplified and commensurable indicator for the use of natural material, but because it does not take into account the harmfulness of materials or the way how the residual material is processed, it does not alone express the amount of environmental impacts. The examination of the mere amount does not differentiate between for example coal, natural gas or waste rock containing usually just sand. Natural gas is, however, substantially more harmful for the ecosystem than sand. Therefore, other methods should also be used to consider the environmental load of a product. The material input coefficient of nuclear fuel is calculated using data from different types of mines. The calculations are made among other things by using the data of an open pit mine (Key Lake, Canada), an underground mine (McArthur River, Canada) and a by-product mine (Olympic Dam, Australia). Furthermore, the coefficient is calculated for nuclear fuel corresponding to the nuclear fuel supply of Teollisuuden Voima (TVO) company in 2001. Because there is some uncertainty in the initial data, the inaccuracy of the final results can be even 20-50 per cent. The value

  13. Phasing Out a Polluting Input

    OpenAIRE

    Eriksson, Clas

    2015-01-01

    This paper explores economic policies related to the potential conflict between economic growth and the environment. It applies a model with directed technological change and focuses on the case with low elasticity of substitution between clean and dirty inputs in production. New technology is substituted for the polluting input, which results in a gradual decline in pollution along the optimal long-run growth path. In contrast to some recent work, the era of pollution and environmental polic...

  14. Deterministic joint remote preparation of an equatorial hybrid state via high-dimensional Einstein-Podolsky-Rosen pairs: active versus passive receiver

    Science.gov (United States)

    Bich, Cao Thi; Dat, Le Thanh; Van Hop, Nguyen; An, Nguyen Ba

    2018-04-01

    Entanglement plays a vital and in many cases non-replaceable role in the quantum network communication. Here, we propose two new protocols to jointly and remotely prepare a special so-called bipartite equatorial state which is hybrid in the sense that it entangles two Hilbert spaces with arbitrary different dimensions D and N (i.e., a type of entanglement between a quDit and a quNit). The quantum channels required to do that are however not necessarily hybrid. In fact, we utilize four high-dimensional Einstein-Podolsky-Rosen pairs, two of which are quDit-quDit entanglements, while the other two are quNit-quNit ones. In the first protocol the receiver has to be involved actively in the process of remote state preparation, while in the second protocol the receiver is passive as he/she needs to participate only in the final step for reconstructing the target hybrid state. Each protocol meets a specific circumstance that may be encountered in practice and both can be performed with unit success probability. Moreover, the concerned equatorial hybrid entangled state can also be jointly prepared for two receivers at two separated locations by slightly modifying the initial particles' distribution, thereby establishing between them an entangled channel ready for a later use.

  15. Stable long-time semiclassical description of zero-point energy in high-dimensional molecular systems.

    Science.gov (United States)

    Garashchuk, Sophya; Rassolov, Vitaly A

    2008-07-14

    Semiclassical implementation of the quantum trajectory formalism [J. Chem. Phys. 120, 1181 (2004)] is further developed to give a stable long-time description of zero-point energy in anharmonic systems of high dimensionality. The method is based on a numerically cheap linearized quantum force approach; stabilizing terms compensating for the linearization errors are added into the time-evolution equations for the classical and nonclassical components of the momentum operator. The wave function normalization and energy are rigorously conserved. Numerical tests are performed for model systems of up to 40 degrees of freedom.

  16. Conjugate-Gradient Neural Networks in Classification of Multisource and Very-High-Dimensional Remote Sensing Data

    Science.gov (United States)

    Benediktsson, J. A.; Swain, P. H.; Ersoy, O. K.

    1993-01-01

    Application of neural networks to classification of remote sensing data is discussed. Conventional two-layer backpropagation is found to give good results in classification of remote sensing data but is not efficient in training. A more efficient variant, based on conjugate-gradient optimization, is used for classification of multisource remote sensing and geographic data and very-high-dimensional data. The conjugate-gradient neural networks give excellent performance in classification of multisource data, but do not compare as well with statistical methods in classification of very-high-dimentional data.

  17. On Optimal Input Design and Model Selection for Communication Channels

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yanyan [ORNL; Djouadi, Seddik M [ORNL; Olama, Mohammed M [ORNL

    2013-01-01

    In this paper, the optimal model (structure) selection and input design which minimize the worst case identification error for communication systems are provided. The problem is formulated using metric complexity theory in a Hilbert space setting. It is pointed out that model selection and input design can be handled independently. Kolmogorov n-width is used to characterize the representation error introduced by model selection, while Gel fand and Time n-widths are used to represent the inherent error introduced by input design. After the model is selected, an optimal input which minimizes the worst case identification error is shown to exist. In particular, it is proven that the optimal model for reducing the representation error is a Finite Impulse Response (FIR) model, and the optimal input is an impulse at the start of the observation interval. FIR models are widely popular in communication systems, such as, in Orthogonal Frequency Division Multiplexing (OFDM) systems.

  18. Local Likelihood Approach for High-Dimensional Peaks-Over-Threshold Inference

    KAUST Repository

    Baki, Zhuldyzay

    2018-05-14

    Global warming is affecting the Earth climate year by year, the biggest difference being observable in increasing temperatures in the World Ocean. Following the long- term global ocean warming trend, average sea surface temperatures across the global tropics and subtropics have increased by 0.4–1◦C in the last 40 years. These rates become even higher in semi-enclosed southern seas, such as the Red Sea, threaten- ing the survival of thermal-sensitive species. As average sea surface temperatures are projected to continue to rise, careful study of future developments of extreme temper- atures is paramount for the sustainability of marine ecosystem and biodiversity. In this thesis, we use Extreme-Value Theory to study sea surface temperature extremes from a gridded dataset comprising 16703 locations over the Red Sea. The data were provided by Operational SST and Sea Ice Analysis (OSTIA), a satellite-based data system designed for numerical weather prediction. After pre-processing the data to account for seasonality and global trends, we analyze the marginal distribution of ex- tremes, defined as observations exceeding a high spatially varying threshold, using the Generalized Pareto distribution. This model allows us to extrapolate beyond the ob- served data to compute the 100-year return levels over the entire Red Sea, confirming the increasing trend of extreme temperatures. To understand the dynamics govern- ing the dependence of extreme temperatures in the Red Sea, we propose a flexible local approach based on R-Pareto processes, which extend the univariate Generalized Pareto distribution to the spatial setting. Assuming that the sea surface temperature varies smoothly over space, we perform inference based on the gradient score method over small regional neighborhoods, in which the data are assumed to be stationary in space. This approach allows us to capture spatial non-stationarity, and to reduce the overall computational cost by taking advantage of

  19. Calculating the sensitivity of wind turbine loads to wind inputs using response surfaces

    DEFF Research Database (Denmark)

    Rinker, Jennifer M.

    2016-01-01

    at a low computational cost. Sobol sensitivity indices (SIs) can then be calculated with relative ease using the calibrated response surface. The proposed methodology is demonstrated by calculating the total sensitivity of the maximum blade root bending moment of the WindPACT 5 MW reference model to four......This paper presents a methodology to calculate wind turbine load sensitivities to turbulence parameters through the use of response surfaces. A response surface is a high-dimensional polynomial surface that can be calibrated to any set of input/output data and then used to generate synthetic data...... turbulence input parameters: a reference mean wind speed, a reference turbulence intensity, the Kaimal length scale, and a novel parameter reflecting the nonstationarity present in the inflow turbulence. The input/output data used to calibrate the response surface were generated for a previous project...

  20. High-Dimensional Additive Hazards Regression for Oral Squamous Cell Carcinoma Using Microarray Data: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Omid Hamidi

    2014-01-01

    Full Text Available Microarray technology results in high-dimensional and low-sample size data sets. Therefore, fitting sparse models is substantial because only a small number of influential genes can reliably be identified. A number of variable selection approaches have been proposed for high-dimensional time-to-event data based on Cox proportional hazards where censoring is present. The present study applied three sparse variable selection techniques of Lasso, smoothly clipped absolute deviation and the smooth integration of counting, and absolute deviation for gene expression survival time data using the additive risk model which is adopted when the absolute effects of multiple predictors on the hazard function are of interest. The performances of used techniques were evaluated by time dependent ROC curve and bootstrap .632+ prediction error curves. The selected genes by all methods were highly significant (P<0.001. The Lasso showed maximum median of area under ROC curve over time (0.95 and smoothly clipped absolute deviation showed the lowest prediction error (0.105. It was observed that the selected genes by all methods improved the prediction of purely clinical model indicating the valuable information containing in the microarray features. So it was concluded that used approaches can satisfactorily predict survival based on selected gene expression measurements.

  1. Network-based regularization for high dimensional SNP data in the case-control study of Type 2 diabetes.

    Science.gov (United States)

    Ren, Jie; He, Tao; Li, Ye; Liu, Sai; Du, Yinhao; Jiang, Yu; Wu, Cen

    2017-05-16

    Over the past decades, the prevalence of type 2 diabetes mellitus (T2D) has been steadily increasing around the world. Despite large efforts devoted to better understand the genetic basis of the disease, the identified susceptibility loci can only account for a small portion of the T2D heritability. Some of the existing approaches proposed for the high dimensional genetic data from the T2D case-control study are limited by analyzing a few number of SNPs at a time from a large pool of SNPs, by ignoring the correlations among SNPs and by adopting inefficient selection techniques. We propose a network constrained regularization method to select important SNPs by taking the linkage disequilibrium into account. To accomodate the case control study, an iteratively reweighted least square algorithm has been developed within the coordinate descent framework where optimization of the regularized logistic loss function is performed with respect to one parameter at a time and iteratively cycle through all the parameters until convergence. In this article, a novel approach is developed to identify important SNPs more effectively through incorporating the interconnections among them in the regularized selection. A coordinate descent based iteratively reweighed least squares (IRLS) algorithm has been proposed. Both the simulation study and the analysis of the Nurses's Health Study, a case-control study of type 2 diabetes data with high dimensional SNP measurements, demonstrate the advantage of the network based approach over the competing alternatives.

  2. Fast metabolite identification with Input Output Kernel Regression

    Science.gov (United States)

    Brouard, Céline; Shen, Huibin; Dührkop, Kai; d'Alché-Buc, Florence; Böcker, Sebastian; Rousu, Juho

    2016-01-01

    Motivation: An important problematic of metabolomics is to identify metabolites using tandem mass spectrometry data. Machine learning methods have been proposed recently to solve this problem by predicting molecular fingerprint vectors and matching these fingerprints against existing molecular structure databases. In this work we propose to address the metabolite identification problem using a structured output prediction approach. This type of approach is not limited to vector output space and can handle structured output space such as the molecule space. Results: We use the Input Output Kernel Regression method to learn the mapping between tandem mass spectra and molecular structures. The principle of this method is to encode the similarities in the input (spectra) space and the similarities in the output (molecule) space using two kernel functions. This method approximates the spectra-molecule mapping in two phases. The first phase corresponds to a regression problem from the input space to the feature space associated to the output kernel. The second phase is a preimage problem, consisting in mapping back the predicted output feature vectors to the molecule space. We show that our approach achieves state-of-the-art accuracy in metabolite identification. Moreover, our method has the advantage of decreasing the running times for the training step and the test step by several orders of magnitude over the preceding methods. Availability and implementation: Contact: celine.brouard@aalto.fi Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307628

  3. Strategies to reduce the complexity of hydrologic data assimilation for high-dimensional models

    Science.gov (United States)

    Hernandez, F.; Liang, X.

    2017-12-01

    Probabilistic forecasts in the geosciences offer invaluable information by allowing to estimate the uncertainty of predicted conditions (including threats like floods and droughts). However, while forecast systems based on modern data assimilation algorithms are capable of producing multi-variate probability distributions of future conditions, the computational resources required to fully characterize the dependencies between the model's state variables render their applicability impractical for high-resolution cases. This occurs because of the quadratic space complexity of storing the covariance matrices that encode these dependencies and the cubic time complexity of performing inference operations with them. In this work we introduce two complementary strategies to reduce the size of the covariance matrices that are at the heart of Bayesian assimilation methods—like some variants of (ensemble) Kalman filters and of particle filters—and variational methods. The first strategy involves the optimized grouping of state variables by clustering individual cells of the model into "super-cells." A dynamic fuzzy clustering approach is used to take into account the states (e.g., soil moisture) and forcings (e.g., precipitation) of each cell at each time step. The second strategy consists in finding a compressed representation of the covariance matrix that still encodes the most relevant information but that can be more efficiently stored and processed. A learning and a belief-propagation inference algorithm are developed to take advantage of this modified low-rank representation. The two proposed strategies are incorporated into OPTIMISTS, a state-of-the-art hybrid Bayesian/variational data assimilation algorithm, and comparative streamflow forecasting tests are performed using two watersheds modeled with the Distributed Hydrology Soil Vegetation Model (DHSVM). Contrasts are made between the efficiency gains and forecast accuracy losses of each strategy used in

  4. High dimensional ICA analysis detects within-network functional connectivity damage of default mode and sensory motor networks in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Ottavia eDipasquale

    2015-02-01

    Full Text Available High dimensional independent component analysis (ICA, compared to low dimensional ICA, allows performing a detailed parcellation of the resting state networks. The purpose of this study was to give further insight into functional connectivity (FC in Alzheimer’s disease (AD using high dimensional ICA. For this reason, we performed both low and high dimensional ICA analyses of resting state fMRI (rfMRI data of 20 healthy controls and 21 AD patients, focusing on the primarily altered default mode network (DMN and exploring the sensory motor network (SMN. As expected, results obtained at low dimensionality were in line with previous literature. Moreover, high dimensional results allowed us to observe either the presence of within-network disconnections and FC damage confined to some of the resting state sub-networks. Due to the higher sensitivity of the high dimensional ICA analysis, our results suggest that high-dimensional decomposition in sub-networks is very promising to better localize FC alterations in AD and that FC damage is not confined to the default mode network.

  5. World Input-Output Network.

    Directory of Open Access Journals (Sweden)

    Federica Cerina

    Full Text Available Production systems, traditionally analyzed as almost independent national systems, are increasingly connected on a global scale. Only recently becoming available, the World Input-Output Database (WIOD is one of the first efforts to construct the global multi-regional input-output (GMRIO tables. By viewing the world input-output system as an interdependent network where the nodes are the individual industries in different economies and the edges are the monetary goods flows between industries, we analyze respectively the global, regional, and local network properties of the so-called world input-output network (WION and document its evolution over time. At global level, we find that the industries are highly but asymmetrically connected, which implies that micro shocks can lead to macro fluctuations. At regional level, we find that the world production is still operated nationally or at most regionally as the communities detected are either individual economies or geographically well defined regions. Finally, at local level, for each industry we compare the network-based measures with the traditional methods of backward linkages. We find that the network-based measures such as PageRank centrality and community coreness measure can give valuable insights into identifying the key industries.

  6. Parameter setting and input reduction

    NARCIS (Netherlands)

    Evers, A.; van Kampen, N.J.|info:eu-repo/dai/nl/126439737

    2008-01-01

    The language acquisition procedure identifies certain properties of the target grammar before others. The evidence from the input is processed in a stepwise order. Section 1 equates that order and its typical effects with an order of parameter setting. The question is how the acquisition procedure

  7. Constituency Input into Budget Management.

    Science.gov (United States)

    Miller, Norman E.

    1995-01-01

    Presents techniques for ensuring constituency involvement in district- and site-level budget management. Outlines four models for securing constituent input and focuses on strategies to orchestrate the more complex model for staff and community participation. Two figures are included. (LMI)

  8. Remote input/output station

    CERN Multimedia

    1972-01-01

    A general view of the remote input/output station installed in building 112 (ISR) and used for submitting jobs to the CDC 6500 and 6600. The card reader on the left and the line printer on the right are operated by programmers on a self-service basis.

  9. Lithium inputs to subduction zones

    NARCIS (Netherlands)

    Bouman, C.; Elliott, T.R.; Vroon, P.Z.

    2004-01-01

    We have studied the sedimentary and basaltic inputs of lithium to subduction zones. Various sediments from DSDP and ODP drill cores in front of the Mariana, South Sandwich, Banda, East Sunda and Lesser Antilles island arcs have been analysed and show highly variable Li contents and δ

  10. Thermodynamics of noncommutative high-dimensional AdS black holes with non-Gaussian smeared matter distributions

    Energy Technology Data Exchange (ETDEWEB)

    Miao, Yan-Gang [Nankai University, School of Physics, Tianjin (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, P.O. Box 2735, Beijing (China); CERN, PH-TH Division, Geneva 23 (Switzerland); Xu, Zhen-Ming [Nankai University, School of Physics, Tianjin (China)

    2016-04-15

    Considering non-Gaussian smeared matter distributions, we investigate the thermodynamic behaviors of the noncommutative high-dimensional Schwarzschild-Tangherlini anti-de Sitter black hole, and we obtain the condition for the existence of extreme black holes. We indicate that the Gaussian smeared matter distribution, which is a special case of non-Gaussian smeared matter distributions, is not applicable for the six- and higher-dimensional black holes due to the hoop conjecture. In particular, the phase transition is analyzed in detail. Moreover, we point out that the Maxwell equal area law holds for the noncommutative black hole whose Hawking temperature is within a specific range, but fails for one whose the Hawking temperature is beyond this range. (orig.)

  11. Thermodynamics of noncommutative high-dimensional AdS black holes with non-Gaussian smeared matter distributions

    CERN Document Server

    Miao, Yan-Gang

    2016-01-01

    Considering non-Gaussian smeared matter distributions, we investigate thermodynamic behaviors of the noncommutative high-dimensional Schwarzschild-Tangherlini anti-de Sitter black hole, and obtain the condition for the existence of extreme black holes. We indicate that the Gaussian smeared matter distribution, which is a special case of non-Gaussian smeared matter distributions, is not applicable for the 6- and higher-dimensional black holes due to the hoop conjecture. In particular, the phase transition is analyzed in detail. Moreover, we point out that the Maxwell equal area law maintains for the noncommutative black hole with the Hawking temperature within a specific range, but fails with the Hawking temperature beyond this range.

  12. Estimation of the local response to a forcing in a high dimensional system using the fluctuation-dissipation theorem

    Directory of Open Access Journals (Sweden)

    F. C. Cooper

    2013-04-01

    Full Text Available The fluctuation-dissipation theorem (FDT has been proposed as a method of calculating the response of the earth's atmosphere to a forcing. For this problem the high dimensionality of the relevant data sets makes truncation necessary. Here we propose a method of truncation based upon the assumption that the response to a localised forcing is spatially localised, as an alternative to the standard method of choosing a number of the leading empirical orthogonal functions. For systems where this assumption holds, the response to any sufficiently small non-localised forcing may be estimated using a set of truncations that are chosen algorithmically. We test our algorithm using 36 and 72 variable versions of a stochastic Lorenz 95 system of ordinary differential equations. We find that, for long integrations, the bias in the response estimated by the FDT is reduced from ~75% of the true response to ~30%.

  13. Efficient computation of k-Nearest Neighbour Graphs for large high-dimensional data sets on GPU clusters.

    Directory of Open Access Journals (Sweden)

    Ali Dashti

    Full Text Available This paper presents an implementation of the brute-force exact k-Nearest Neighbor Graph (k-NNG construction for ultra-large high-dimensional data cloud. The proposed method uses Graphics Processing Units (GPUs and is scalable with multi-levels of parallelism (between nodes of a cluster, between different GPUs on a single node, and within a GPU. The method is applicable to homogeneous computing clusters with a varying number of nodes and GPUs per node. We achieve a 6-fold speedup in data processing as compared with an optimized method running on a cluster of CPUs and bring a hitherto impossible [Formula: see text]-NNG generation for a dataset of twenty million images with 15 k dimensionality into the realm of practical possibility.

  14. Clustering high-dimensional mixed data to uncover sub-phenotypes: joint analysis of phenotypic and genotypic data.

    Science.gov (United States)

    McParland, D; Phillips, C M; Brennan, L; Roche, H M; Gormley, I C

    2017-12-10

    The LIPGENE-SU.VI.MAX study, like many others, recorded high-dimensional continuous phenotypic data and categorical genotypic data. LIPGENE-SU.VI.MAX focuses on the need to account for both phenotypic and genetic factors when studying the metabolic syndrome (MetS), a complex disorder that can lead to higher risk of type 2 diabetes and cardiovascular disease. Interest lies in clustering the LIPGENE-SU.VI.MAX participants into homogeneous groups or sub-phenotypes, by jointly considering their phenotypic and genotypic data, and in determining which variables are discriminatory. A novel latent variable model that elegantly accommodates high dimensional, mixed data is developed to cluster LIPGENE-SU.VI.MAX participants using a Bayesian finite mixture model. A computationally efficient variable selection algorithm is incorporated, estimation is via a Gibbs sampling algorithm and an approximate BIC-MCMC criterion is developed to select the optimal model. Two clusters or sub-phenotypes ('healthy' and 'at risk') are uncovered. A small subset of variables is deemed discriminatory, which notably includes phenotypic and genotypic variables, highlighting the need to jointly consider both factors. Further, 7 years after the LIPGENE-SU.VI.MAX data were collected, participants underwent further analysis to diagnose presence or absence of the MetS. The two uncovered sub-phenotypes strongly correspond to the 7-year follow-up disease classification, highlighting the role of phenotypic and genotypic factors in the MetS and emphasising the potential utility of the clustering approach in early screening. Additionally, the ability of the proposed approach to define the uncertainty in sub-phenotype membership at the participant level is synonymous with the concepts of precision medicine and nutrition. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  15. Input measurements in reprocessing plants

    International Nuclear Information System (INIS)

    Trincherini, P.R.; Facchetti, S.

    1980-01-01

    The aim of this work is to give a review of the methods and the problems encountered in measurements in 'input accountability tanks' of irradiated fuel treatment plants. This study was prompted by the conviction that more and more precise techniques and methods should be at the service of safeguards organizations and that ever greater efforts should be directed towards promoting knowledge of them among operators and all those general area of interest includes the nuclear fuel cycle. The overall intent is to show the necessity of selecting methods which produce measurements which are not only more precise but are absolutely reliable both for routine plant operation and for safety checks in the input area. A description and a critical evaluation of the most common physical and chemical methods are provided, together with an estimate of the precision and accuracy obtained in real operating conditions

  16. State space and input-output linear systems

    CERN Document Server

    Delchamps, David F

    1988-01-01

    It is difficult for me to forget the mild sense of betrayal I felt some ten years ago when I discovered, with considerable dismay, that my two favorite books on linear system theory - Desoer's Notes for a Second Course on Linear Systems and Brockett's Finite Dimensional Linear Systems - were both out of print. Since that time, of course, linear system theory has undergone a transformation of the sort which always attends the maturation of a theory whose range of applicability is expanding in a fashion governed by technological developments and by the rate at which such advances become a part of engineering practice. The growth of the field has inspired the publication of some excellent books; the encyclopedic treatises by Kailath and Chen, in particular, come immediately to mind. Nonetheless, I was inspired to write this book primarily by my practical needs as a teacher and researcher in the field. For the past five years, I have taught a one semester first year gradu­ ate level linear system theory course i...

  17. Approximation of Quantities of Interest in Stochastic PDEs by the Random Discrete L^2 Projection on Polynomial Spaces

    KAUST Repository

    Migliorati, G.

    2013-05-30

    In this work we consider the random discrete L^2 projection on polynomial spaces (hereafter RDP) for the approximation of scalar quantities of interest (QOIs) related to the solution of a partial differential equation model with random input parameters. In the RDP technique the QOI is first computed for independent samples of the random input parameters, as in a standard Monte Carlo approach, and then the QOI is approximated by a multivariate polynomial function of the input parameters using a discrete least squares approach. We consider several examples including the Darcy equations with random permeability, the linear elasticity equations with random elastic coefficient, and the Navier--Stokes equations in random geometries and with random fluid viscosity. We show that the RDP technique is well suited to QOIs that depend smoothly on a moderate number of random parameters. Our numerical tests confirm the theoretical findings in [G. Migliorati, F. Nobile, E. von Schwerin, and R. Tempone, Analysis of the Discrete $L^2$ Projection on Polynomial Spaces with Random Evaluations, MOX report 46-2011, Politecnico di Milano, Milano, Italy, submitted], which have shown that, in the case of a single uniformly distributed random parameter, the RDP technique is stable and optimally convergent if the number of sampling points is proportional to the square of the dimension of the polynomial space. Here optimality means that the weighted $L^2$ norm of the RDP error is bounded from above by the best $L^\\\\infty$ error achievable in the given polynomial space, up to logarithmic factors. In the case of several random input parameters, the numerical evidence indicates that the condition on quadratic growth of the number of sampling points could be relaxed to a linear growth and still achieve stable and optimal convergence. This makes the RDP technique very promising for moderately high dimensional uncertainty quantification.

  18. SkyFACT: high-dimensional modeling of gamma-ray emission with adaptive templates and penalized likelihoods

    Energy Technology Data Exchange (ETDEWEB)

    Storm, Emma; Weniger, Christoph [GRAPPA, Institute of Physics, University of Amsterdam, Science Park 904, 1090 GL Amsterdam (Netherlands); Calore, Francesca, E-mail: e.m.storm@uva.nl, E-mail: c.weniger@uva.nl, E-mail: francesca.calore@lapth.cnrs.fr [LAPTh, CNRS, 9 Chemin de Bellevue, BP-110, Annecy-le-Vieux, 74941, Annecy Cedex (France)

    2017-08-01

    We present SkyFACT (Sky Factorization with Adaptive Constrained Templates), a new approach for studying, modeling and decomposing diffuse gamma-ray emission. Like most previous analyses, the approach relies on predictions from cosmic-ray propagation codes like GALPROP and DRAGON. However, in contrast to previous approaches, we account for the fact that models are not perfect and allow for a very large number (∼> 10{sup 5}) of nuisance parameters to parameterize these imperfections. We combine methods of image reconstruction and adaptive spatio-spectral template regression in one coherent hybrid approach. To this end, we use penalized Poisson likelihood regression, with regularization functions that are motivated by the maximum entropy method. We introduce methods to efficiently handle the high dimensionality of the convex optimization problem as well as the associated semi-sparse covariance matrix, using the L-BFGS-B algorithm and Cholesky factorization. We test the method both on synthetic data as well as on gamma-ray emission from the inner Galaxy, |ℓ|<90{sup o} and | b |<20{sup o}, as observed by the Fermi Large Area Telescope. We finally define a simple reference model that removes most of the residual emission from the inner Galaxy, based on conventional diffuse emission components as well as components for the Fermi bubbles, the Fermi Galactic center excess, and extended sources along the Galactic disk. Variants of this reference model can serve as basis for future studies of diffuse emission in and outside the Galactic disk.

  19. CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Malgorzata Nowicka

    2017-05-01

    Full Text Available High dimensional mass and flow cytometry (HDCyto experiments have become a method of choice for high throughput interrogation and characterization of cell populations.Here, we present an R-based pipeline for differential analyses of HDCyto data, largely based on Bioconductor packages. We computationally define cell populations using FlowSOM clustering, and facilitate an optional but reproducible strategy for manual merging of algorithm-generated clusters. Our workflow offers different analysis paths, including association of cell type abundance with a phenotype or changes in signaling markers within specific subpopulations, or differential analyses of aggregated signals. Importantly, the differential analyses we show are based on regression frameworks where the HDCyto data is the response; thus, we are able to model arbitrary experimental designs, such as those with batch effects, paired designs and so on. In particular, we apply generalized linear mixed models to analyses of cell population abundance or cell-population-specific analyses of signaling markers, allowing overdispersion in cell count or aggregated signals across samples to be appropriately modeled. To support the formal statistical analyses, we encourage exploratory data analysis at every step, including quality control (e.g. multi-dimensional scaling plots, reporting of clustering results (dimensionality reduction, heatmaps with dendrograms and differential analyses (e.g. plots of aggregated signals.

  20. Constrained optimization by radial basis function interpolation for high-dimensional expensive black-box problems with infeasible initial points

    Science.gov (United States)

    Regis, Rommel G.

    2014-02-01

    This article develops two new algorithms for constrained expensive black-box optimization that use radial basis function surrogates for the objective and constraint functions. These algorithms are called COBRA and Extended ConstrLMSRBF and, unlike previous surrogate-based approaches, they can be used for high-dimensional problems where all initial points are infeasible. They both follow a two-phase approach where the first phase finds a feasible point while the second phase improves this feasible point. COBRA and Extended ConstrLMSRBF are compared with alternative methods on 20 test problems and on the MOPTA08 benchmark automotive problem (D.R. Jones, Presented at MOPTA 2008), which has 124 decision variables and 68 black-box inequality constraints. The alternatives include a sequential penalty derivative-free algorithm, a direct search method with kriging surrogates, and two multistart methods. Numerical results show that COBRA algorithms are competitive with Extended ConstrLMSRBF and they generally outperform the alternatives on the MOPTA08 problem and most of the test problems.

  1. Transforming high-dimensional potential energy surfaces into sum-of-products form using Monte Carlo methods

    Science.gov (United States)

    Schröder, Markus; Meyer, Hans-Dieter

    2017-08-01

    We propose a Monte Carlo method, "Monte Carlo Potfit," for transforming high-dimensional potential energy surfaces evaluated on discrete grid points into a sum-of-products form, more precisely into a Tucker form. To this end we use a variational ansatz in which we replace numerically exact integrals with Monte Carlo integrals. This largely reduces the numerical cost by avoiding the evaluation of the potential on all grid points and allows a treatment of surfaces up to 15-18 degrees of freedom. We furthermore show that the error made with this ansatz can be controlled and vanishes in certain limits. We present calculations on the potential of HFCO to demonstrate the features of the algorithm. To demonstrate the power of the method, we transformed a 15D potential of the protonated water dimer (Zundel cation) in a sum-of-products form and calculated the ground and lowest 26 vibrationally excited states of the Zundel cation with the multi-configuration time-dependent Hartree method.

  2. Modeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations.

    Science.gov (United States)

    Wu, Shuang; Liu, Zhi-Ping; Qiu, Xing; Wu, Hulin

    2014-01-01

    The immune response to viral infection is regulated by an intricate network of many genes and their products. The reverse engineering of gene regulatory networks (GRNs) using mathematical models from time course gene expression data collected after influenza infection is key to our understanding of the mechanisms involved in controlling influenza infection within a host. A five-step pipeline: detection of temporally differentially expressed genes, clustering genes into co-expressed modules, identification of network structure, parameter estimate refinement, and functional enrichment analysis, is developed for reconstructing high-dimensional dynamic GRNs from genome-wide time course gene expression data. Applying the pipeline to the time course gene expression data from influenza-infected mouse lungs, we have identified 20 distinct temporal expression patterns in the differentially expressed genes and constructed a module-based dynamic network using a linear ODE model. Both intra-module and inter-module annotations and regulatory relationships of our inferred network show some interesting findings and are highly consistent with existing knowledge about the immune response in mice after influenza infection. The proposed method is a computationally efficient, data-driven pipeline bridging experimental data, mathematical modeling, and statistical analysis. The application to the influenza infection data elucidates the potentials of our pipeline in providing valuable insights into systematic modeling of complicated biological processes.

  3. Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and “hidden” dimensions

    Science.gov (United States)

    Meng, Xi; Nguyen, Bao D.; Ridge, Clark; Shaka, A. J.

    2009-01-01

    High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to “reduced-dimensionality” strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the Filter Diagonalization Method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths. PMID:18926747

  4. Big Data Challenges of High-Dimensional Continuous-Time Mean-Variance Portfolio Selection and a Remedy.

    Science.gov (United States)

    Chiu, Mei Choi; Pun, Chi Seng; Wong, Hoi Ying

    2017-08-01

    Investors interested in the global financial market must analyze financial securities internationally. Making an optimal global investment decision involves processing a huge amount of data for a high-dimensional portfolio. This article investigates the big data challenges of two mean-variance optimal portfolios: continuous-time precommitment and constant-rebalancing strategies. We show that both optimized portfolios implemented with the traditional sample estimates converge to the worst performing portfolio when the portfolio size becomes large. The crux of the problem is the estimation error accumulated from the huge dimension of stock data. We then propose a linear programming optimal (LPO) portfolio framework, which applies a constrained ℓ 1 minimization to the theoretical optimal control to mitigate the risk associated with the dimensionality issue. The resulting portfolio becomes a sparse portfolio that selects stocks with a data-driven procedure and hence offers a stable mean-variance portfolio in practice. When the number of observations becomes large, the LPO portfolio converges to the oracle optimal portfolio, which is free of estimation error, even though the number of stocks grows faster than the number of observations. Our numerical and empirical studies demonstrate the superiority of the proposed approach. © 2017 Society for Risk Analysis.

  5. Low-storage implicit/explicit Runge-Kutta schemes for the simulation of stiff high-dimensional ODE systems

    Science.gov (United States)

    Cavaglieri, Daniele; Bewley, Thomas

    2015-04-01

    Implicit/explicit (IMEX) Runge-Kutta (RK) schemes are effective for time-marching ODE systems with both stiff and nonstiff terms on the RHS; such schemes implement an (often A-stable or better) implicit RK scheme for the stiff part of the ODE, which is often linear, and, simultaneously, a (more convenient) explicit RK scheme for the nonstiff part of the ODE, which is often nonlinear. Low-storage RK schemes are especially effective for time-marching high-dimensional ODE discretizations of PDE systems on modern (cache-based) computational hardware, in which memory management is often the most significant computational bottleneck. In this paper, we develop and characterize eight new low-storage implicit/explicit RK schemes which have higher accuracy and better stability properties than the only low-storage implicit/explicit RK scheme available previously, the venerable second-order Crank-Nicolson/Runge-Kutta-Wray (CN/RKW3) algorithm that has dominated the DNS/LES literature for the last 25 years, while requiring similar storage (two, three, or four registers of length N) and comparable floating-point operations per timestep.

  6. Chemical sensors are hybrid-input memristors

    Science.gov (United States)

    Sysoev, V. I.; Arkhipov, V. E.; Okotrub, A. V.; Pershin, Y. V.

    2018-04-01

    Memristors are two-terminal electronic devices whose resistance depends on the history of input signal (voltage or current). Here we demonstrate that the chemical gas sensors can be considered as memristors with a generalized (hybrid) input, namely, with the input consisting of the voltage, analyte concentrations and applied temperature. The concept of hybrid-input memristors is demonstrated experimentally using a single-walled carbon nanotubes chemical sensor. It is shown that with respect to the hybrid input, the sensor exhibits some features common with memristors such as the hysteretic input-output characteristics. This different perspective on chemical gas sensors may open new possibilities for smart sensor applications.

  7. Optimal classifier selection and negative bias in error rate estimation: an empirical study on high-dimensional prediction

    Directory of Open Access Journals (Sweden)

    Boulesteix Anne-Laure

    2009-12-01

    Full Text Available Abstract Background In biometric practice, researchers often apply a large number of different methods in a "trial-and-error" strategy to get as much as possible out of their data and, due to publication pressure or pressure from the consulting customer, present only the most favorable results. This strategy may induce a substantial optimistic bias in prediction error estimation, which is quantitatively assessed in the present manuscript. The focus of our work is on class prediction based on high-dimensional data (e.g. microarray data, since such analyses are particularly exposed to this kind of bias. Methods In our study we consider a total of 124 variants of classifiers (possibly including variable selection or tuning steps within a cross-validation evaluation scheme. The classifiers are applied to original and modified real microarray data sets, some of which are obtained by randomly permuting the class labels to mimic non-informative predictors while preserving their correlation structure. Results We assess the minimal misclassification rate over the different variants of classifiers in order to quantify the bias arising when the optimal classifier is selected a posteriori in a data-driven manner. The bias resulting from the parameter tuning (including gene selection parameters as a special case and the bias resulting from the choice of the classification method are examined both separately and jointly. Conclusions The median minimal error rate over the investigated classifiers was as low as 31% and 41% based on permuted uninformative predictors from studies on colon cancer and prostate cancer, respectively. We conclude that the strategy to present only the optimal result is not acceptable because it yields a substantial bias in error rate estimation, and suggest alternative approaches for properly reporting classification accuracy.

  8. Repositioning Recitation Input in College English Teaching

    Science.gov (United States)

    Xu, Qing

    2009-01-01

    This paper tries to discuss how recitation input helps overcome the negative influences on the basis of second language acquisition theory and confirms the important role that recitation input plays in improving college students' oral and written English.

  9. An overview of techniques for linking high-dimensional molecular data to time-to-event endpoints by risk prediction models.

    Science.gov (United States)

    Binder, Harald; Porzelius, Christine; Schumacher, Martin

    2011-03-01

    Analysis of molecular data promises identification of biomarkers for improving prognostic models, thus potentially enabling better patient management. For identifying such biomarkers, risk prediction models can be employed that link high-dimensional molecular covariate data to a clinical endpoint. In low-dimensional settings, a multitude of statistical techniques already exists for building such models, e.g. allowing for variable selection or for quantifying the added value of a new biomarker. We provide an overview of techniques for regularized estimation that transfer this toward high-dimensional settings, with a focus on models for time-to-event endpoints. Techniques for incorporating specific covariate structure are discussed, as well as techniques for dealing with more complex endpoints. Employing gene expression data from patients with diffuse large B-cell lymphoma, some typical modeling issues from low-dimensional settings are illustrated in a high-dimensional application. First, the performance of classical stepwise regression is compared to stage-wise regression, as implemented by a component-wise likelihood-based boosting approach. A second issues arises, when artificially transforming the response into a binary variable. The effects of the resulting loss of efficiency and potential bias in a high-dimensional setting are illustrated, and a link to competing risks models is provided. Finally, we discuss conditions for adequately quantifying the added value of high-dimensional gene expression measurements, both at the stage of model fitting and when performing evaluation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. A Penalized Likelihood Framework For High-Dimensional Phylogenetic Comparative Methods And An Application To New-World Monkeys Brain Evolution.

    Science.gov (United States)

    Julien, Clavel; Leandro, Aristide; Hélène, Morlon

    2018-06-19

    Working with high-dimensional phylogenetic comparative datasets is challenging because likelihood-based multivariate methods suffer from low statistical performances as the number of traits p approaches the number of species n and because some computational complications occur when p exceeds n. Alternative phylogenetic comparative methods have recently been proposed to deal with the large p small n scenario but their use and performances are limited. Here we develop a penalized likelihood framework to deal with high-dimensional comparative datasets. We propose various penalizations and methods for selecting the intensity of the penalties. We apply this general framework to the estimation of parameters (the evolutionary trait covariance matrix and parameters of the evolutionary model) and model comparison for the high-dimensional multivariate Brownian (BM), Early-burst (EB), Ornstein-Uhlenbeck (OU) and Pagel's lambda models. We show using simulations that our penalized likelihood approach dramatically improves the estimation of evolutionary trait covariance matrices and model parameters when p approaches n, and allows for their accurate estimation when p equals or exceeds n. In addition, we show that penalized likelihood models can be efficiently compared using Generalized Information Criterion (GIC). We implement these methods, as well as the related estimation of ancestral states and the computation of phylogenetic PCA in the R package RPANDA and mvMORPH. Finally, we illustrate the utility of the new proposed framework by evaluating evolutionary models fit, analyzing integration patterns, and reconstructing evolutionary trajectories for a high-dimensional 3-D dataset of brain shape in the New World monkeys. We find a clear support for an Early-burst model suggesting an early diversification of brain morphology during the ecological radiation of the clade. Penalized likelihood offers an efficient way to deal with high-dimensional multivariate comparative data.

  11. Characterization of Input Current Interharmonics in Adjustable Speed Drives

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Zare, Firuz

    2017-01-01

    This paper investigates the interharmonic generation process in the input current of double-stage Adjustable Speed Drives (ASDs) based on voltage source inverters and front-end diode rectifiers. The effects of the inverter output-side low order harmonics, caused by implementing the double......-edge symmetrical regularly sampled Space Vector Modulation (SVM) technique, on the input current interharmonic components are presented and discussed. Particular attention is also given to the influence of the asymmetrical regularly sampled modulation technique on the drive input current interharmonics....... The developed theoretical analysis predicts the drive interharmonic frequency locations with respect to the selected sampling strategies. Simulation and experimental results on a 2.5 kW ASD system verify the effectiveness of the theoretical analysis....

  12. Textual Enhancement of Input: Issues and Possibilities

    Science.gov (United States)

    Han, ZhaoHong; Park, Eun Sung; Combs, Charles

    2008-01-01

    The input enhancement hypothesis proposed by Sharwood Smith (1991, 1993) has stimulated considerable research over the last 15 years. This article reviews the research on textual enhancement of input (TE), an area where the majority of input enhancement studies have aggregated. Methodological idiosyncrasies are the norm of this body of research.…

  13. 7 CFR 3430.607 - Stakeholder input.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Stakeholder input. 3430.607 Section 3430.607 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... § 3430.607 Stakeholder input. CSREES shall seek and obtain stakeholder input through a variety of forums...

  14. 7 CFR 3430.15 - Stakeholder input.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Stakeholder input. 3430.15 Section 3430.15... Stakeholder input. Section 103(c)(2) of the Agricultural Research, Extension, and Education Reform Act of 1998... RFAs for competitive programs. CSREES will provide instructions for submission of stakeholder input in...

  15. Turn customer input into innovation.

    Science.gov (United States)

    Ulwick, Anthony W

    2002-01-01

    It's difficult to find a company these days that doesn't strive to be customer-driven. Too bad, then, that most companies go about the process of listening to customers all wrong--so wrong, in fact, that they undermine innovation and, ultimately, the bottom line. What usually happens is this: Companies ask their customers what they want. Customers offer solutions in the form of products or services. Companies then deliver these tangibles, and customers just don't buy. The reason is simple--customers aren't expert or informed enough to come up with solutions. That's what your R&D team is for. Rather, customers should be asked only for outcomes--what they want a new product or service to do for them. The form the solutions take should be up to you, and you alone. Using Cordis Corporation as an example, this article describes, in fine detail, a series of effective steps for capturing, analyzing, and utilizing customer input. First come indepth interviews, in which a moderator works with customers to deconstruct a process or activity in order to unearth "desired outcomes." Addressing participants' comments one at a time, the moderator rephrases them to be both unambiguous and measurable. Once the interviews are complete, researchers then compile a comprehensive list of outcomes that participants rank in order of importance and degree to which they are satisfied by existing products. Finally, using a simple mathematical formula called the "opportunity calculation," researchers can learn the relative attractiveness of key opportunity areas. These data can be used to uncover opportunities for product development, to properly segment markets, and to conduct competitive analysis.

  16. PREVIMER : Meteorological inputs and outputs

    Science.gov (United States)

    Ravenel, H.; Lecornu, F.; Kerléguer, L.

    2009-09-01

    PREVIMER is a pre-operational system aiming to provide a wide range of users, from private individuals to professionals, with short-term forecasts about the coastal environment along the French coastlines bordering the English Channel, the Atlantic Ocean, and the Mediterranean Sea. Observation data and digital modelling tools first provide 48-hour (probably 96-hour by summer 2009) forecasts of sea states, currents, sea water levels and temperatures. The follow-up of an increasing number of biological parameters will, in time, complete this overview of coastal environment. Working in partnership with the French Naval Hydrographic and Oceanographic Service (Service Hydrographique et Océanographique de la Marine, SHOM), the French National Weather Service (Météo-France), the French public science and technology research institute (Institut de Recherche pour le Développement, IRD), the European Institute of Marine Studies (Institut Universitaire Européen de la Mer, IUEM) and many others, IFREMER (the French public institute fo marine research) is supplying the technologies needed to ensure this pertinent information, available daily on Internet at http://www.previmer.org, and stored at the Operational Coastal Oceanographic Data Centre. Since 2006, PREVIMER publishes the results of demonstrators assigned to limited geographic areas and to specific applications. This system remains experimental. The following topics are covered : Hydrodynamic circulation, sea states, follow-up of passive tracers, conservative or non-conservative (specifically of microbiological origin), biogeochemical state, primary production. Lastly, PREVIMER provides researchers and R&D departments with modelling tools and access to the database, in which the observation data and the modelling results are stored, to undertake environmental studies on new sites. The communication will focus on meteorological inputs to and outputs from PREVIMER. It will draw the lessons from almost 3 years during

  17. Space-by-time manifold representation of dynamic facial expressions for emotion categorization

    Science.gov (United States)

    Delis, Ioannis; Chen, Chaona; Jack, Rachael E.; Garrod, Oliver G. B.; Panzeri, Stefano; Schyns, Philippe G.

    2016-01-01

    Visual categorization is the brain computation that reduces high-dimensional information in the visual environment into a smaller set of meaningful categories. An important problem in visual neuroscience is to identify the visual information that the brain must represent and then use to categorize visual inputs. Here we introduce a new mathematical formalism—termed space-by-time manifold decomposition—that describes this information as a low-dimensional manifold separable in space and time. We use this decomposition to characterize the representations used by observers to categorize the six classic facial expressions of emotion (happy, surprise, fear, disgust, anger, and sad). By means of a Generative Face Grammar, we presented random dynamic facial movements on each experimental trial and used subjective human perception to identify the facial movements that correlate with each emotion category. When the random movements projected onto the categorization manifold region corresponding to one of the emotion categories, observers categorized the stimulus accordingly; otherwise they selected “other.” Using this information, we determined both the Action Unit and temporal components whose linear combinations lead to reliable categorization of each emotion. In a validation experiment, we confirmed the psychological validity of the resulting space-by-time manifold representation. Finally, we demonstrated the importance of temporal sequencing for accurate emotion categorization and identified the temporal dynamics of Action Unit components that cause typical confusions between specific emotions (e.g., fear and surprise) as well as those resolving these confusions. PMID:27305521

  18. Iterative Bayesian Model Averaging: a method for the application of survival analysis to high-dimensional microarray data

    Directory of Open Access Journals (Sweden)

    Raftery Adrian E

    2009-02-01

    Full Text Available Abstract Background Microarray technology is increasingly used to identify potential biomarkers for cancer prognostics and diagnostics. Previously, we have developed the iterative Bayesian Model Averaging (BMA algorithm for use in classification. Here, we extend the iterative BMA algorithm for application to survival analysis on high-dimensional microarray data. The main goal in applying survival analysis to microarray data is to determine a highly predictive model of patients' time to event (such as death, relapse, or metastasis using a small number of selected genes. Our multivariate procedure combines the effectiveness of multiple contending models by calculating the weighted average of their posterior probability distributions. Our results demonstrate that our iterative BMA algorithm for survival analysis achieves high prediction accuracy while consistently selecting a small and cost-effective number of predictor genes. Results We applied the iterative BMA algorithm to two cancer datasets: breast cancer and diffuse large B-cell lymphoma (DLBCL data. On the breast cancer data, the algorithm selected a total of 15 predictor genes across 84 contending models from the training data. The maximum likelihood estimates of the selected genes and the posterior probabilities of the selected models from the training data were used to divide patients in the test (or validation dataset into high- and low-risk categories. Using the genes and models determined from the training data, we assigned patients from the test data into highly distinct risk groups (as indicated by a p-value of 7.26e-05 from the log-rank test. Moreover, we achieved comparable results using only the 5 top selected genes with 100% posterior probabilities. On the DLBCL data, our iterative BMA procedure selected a total of 25 genes across 3 contending models from the training data. Once again, we assigned the patients in the validation set to significantly distinct risk groups (p

  19. High-Dimensional Modeling for Cytometry: Building Rock Solid Models Using GemStone™ and Verity Cen-se'™ High-Definition t-SNE Mapping.

    Science.gov (United States)

    Bruce Bagwell, C

    2018-01-01

    This chapter outlines how to approach the complex tasks associated with designing models for high-dimensional cytometry data. Unlike gating approaches, modeling lends itself to automation and accounts for measurement overlap among cellular populations. Designing these models is now easier because of a new technique called high-definition t-SNE mapping. Nontrivial examples are provided that serve as a guide to create models that are consistent with data.

  20. Input filter compensation for switching regulators

    Science.gov (United States)

    Lee, F. C.; Kelkar, S. S.

    1982-01-01

    The problems caused by the interaction between the input filter, output filter, and the control loop are discussed. The input filter design is made more complicated because of the need to avoid performance degradation and also stay within the weight and loss limitations. Conventional input filter design techniques are then dicussed. The concept of pole zero cancellation is reviewed; this concept is the basis for an approach to control the peaking of the output impedance of the input filter and thus mitigate some of the problems caused by the input filter. The proposed approach for control of the peaking of the output impedance of the input filter is to use a feedforward loop working in conjunction with feedback loops, thus forming a total state control scheme. The design of the feedforward loop for a buck regulator is described. A possible implementation of the feedforward loop design is suggested.

  1. Visualization of virtual slave manipulator using the master input device

    International Nuclear Information System (INIS)

    Kim, S. H.; Song, T. K.; Lee, J. Y.; Yoon, J. S.

    2003-01-01

    To handle the high level radioactive materials such a spent fuel, the Master-Slave Manipulators (MSM) are widely used as a remote handling device in nuclear facilities such as the hot cell with sealed and shielded space. In this paper, the Digital Mockup which simulates the remote operation of the Advanced Conditioning Process(ACP) is developed. Also, the workspace and the motion of the slave manipulator, as well as, the remote operation task should be analyzed. The process equipment of ACP and Maintenance/Handling Device are drawn in 3D CAD models using IGRIP. Modeling device of manipulator is assigned with various mobiles attributes such as a relative position, kinematics constraints, and a range of mobility. The 3D graphic simulator using the external input device of space ball displays the movement of manipulator. To connect the external input device to the graphic simulator, the interface program of external input device with 6 DOF is deigned using the Low Level Tele-operation Interface (LLTI). The experimental result shows that the developed simulation system gives much-improved human interface characteristics and shows satisfactory response characteristics in terms of synchronization speed. This should be useful for the development of work's education system in the virtual environment

  2. High Input Voltage, Silicon Carbide Power Processing Unit Performance Demonstration

    Science.gov (United States)

    Bozak, Karin E.; Pinero, Luis R.; Scheidegger, Robert J.; Aulisio, Michael V.; Gonzalez, Marcelo C.; Birchenough, Arthur G.

    2015-01-01

    A silicon carbide brassboard power processing unit has been developed by the NASA Glenn Research Center in Cleveland, Ohio. The power processing unit operates from two sources: a nominal 300 Volt high voltage input bus and a nominal 28 Volt low voltage input bus. The design of the power processing unit includes four low voltage, low power auxiliary supplies, and two parallel 7.5 kilowatt (kW) discharge power supplies that are capable of providing up to 15 kilowatts of total power at 300 to 500 Volts (V) to the thruster. Additionally, the unit contains a housekeeping supply, high voltage input filter, low voltage input filter, and master control board, such that the complete brassboard unit is capable of operating a 12.5 kilowatt Hall effect thruster. The performance of the unit was characterized under both ambient and thermal vacuum test conditions, and the results demonstrate exceptional performance with full power efficiencies exceeding 97%. The unit was also tested with a 12.5kW Hall effect thruster to verify compatibility and output filter specifications. With space-qualified silicon carbide or similar high voltage, high efficiency power devices, this would provide a design solution to address the need for high power electric propulsion systems.

  3. READDATA: a FORTRAN 77 codeword input package

    International Nuclear Information System (INIS)

    Lander, P.A.

    1983-07-01

    A new codeword input package has been produced as a result of the incompatibility between different dialects of FORTRAN, especially when character variables are passed as parameters. This report is for those who wish to use a codeword input package with FORTRAN 77. The package, called ''Readdata'', attempts to combine the best features of its predecessors such as BINPUT and pseudo-BINPUT. (author)

  4. CREATING INPUT TABLES FROM WAPDEG FOR RIP

    International Nuclear Information System (INIS)

    K.G. Mon

    1998-01-01

    The purpose of this calculation is to create tables for input into RIP ver. 5.18 (Integrated Probabilistic Simulator for Environmental Systems) from WAPDEG ver. 3.06 (Waste Package Degradation) output. This calculation details the creation of the RIP input tables for TSPA-VA REV.00

  5. Wave energy input into the Ekman layer

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This paper is concerned with the wave energy input into the Ekman layer, based on 3 observational facts that surface waves could significantly affect the profile of the Ekman layer. Under the assumption of constant vertical diffusivity, the analytical form of wave energy input into the Ekman layer is derived. Analysis of the energy balance shows that the energy input to the Ekman layer through the wind stress and the interaction of the Stokes-drift with planetary vorticity can be divided into two kinds. One is the wind energy input, and the other is the wave energy input which is dependent on wind speed, wave characteristics and the wind direction relative to the wave direction. Estimates of wave energy input show that wave energy input can be up to 10% in high-latitude and high-wind speed areas and higher than 20% in the Antarctic Circumpolar Current, compared with the wind energy input into the classical Ekman layer. Results of this paper are of significance to the study of wave-induced large scale effects.

  6. Input Enhancement and L2 Question Formation.

    Science.gov (United States)

    White, Lydia; And Others

    1991-01-01

    Investigated the extent to which form-focused instruction and corrective feedback (i.e., "input enhancement"), provided within a primarily communicative program, contribute to learners' accuracy in question formation. Study results are interpreted as evidence that input enhancement can bring about genuine changes in learners' interlanguage…

  7. Statistical identification of effective input variables

    International Nuclear Information System (INIS)

    Vaurio, J.K.

    1982-09-01

    A statistical sensitivity analysis procedure has been developed for ranking the input data of large computer codes in the order of sensitivity-importance. The method is economical for large codes with many input variables, since it uses a relatively small number of computer runs. No prior judgemental elimination of input variables is needed. The sceening method is based on stagewise correlation and extensive regression analysis of output values calculated with selected input value combinations. The regression process deals with multivariate nonlinear functions, and statistical tests are also available for identifying input variables that contribute to threshold effects, i.e., discontinuities in the output variables. A computer code SCREEN has been developed for implementing the screening techniques. The efficiency has been demonstrated by several examples and applied to a fast reactor safety analysis code (Venus-II). However, the methods and the coding are general and not limited to such applications

  8. Multi-Scale Singularity Trees: Soft-Linked Scale-Space Hierarchies

    DEFF Research Database (Denmark)

    Somchaipeng, Kerawit; Sporring, Jon; Kreiborg, Sven

    2005-01-01

    We consider images as manifolds embedded in a hybrid of a high dimensional space of coordinates and features. Using the proposed energy functional and mathematical landmarks, images are partitioned into segments. The nesting of image segments occurring at catastrophe points in the scale-space is ...

  9. Measuring Input Thresholds on an Existing Board

    Science.gov (United States)

    Kuperman, Igor; Gutrich, Daniel G.; Berkun, Andrew C.

    2011-01-01

    A critical PECL (positive emitter-coupled logic) interface to Xilinx interface needed to be changed on an existing flight board. The new Xilinx input interface used a CMOS (complementary metal-oxide semiconductor) type of input, and the driver could meet its thresholds typically, but not in worst-case, according to the data sheet. The previous interface had been based on comparison with an external reference, but the CMOS input is based on comparison with an internal divider from the power supply. A way to measure what the exact input threshold was for this device for 64 inputs on a flight board was needed. The measurement technique allowed an accurate measurement of the voltage required to switch a Xilinx input from high to low for each of the 64 lines, while only probing two of them. Directly driving an external voltage was considered too risky, and tests done on any other unit could not be used to qualify the flight board. The two lines directly probed gave an absolute voltage threshold calibration, while data collected on the remaining 62 lines without probing gave relative measurements that could be used to identify any outliers. The PECL interface was forced to a long-period square wave by driving a saturated square wave into the ADC (analog to digital converter). The active pull-down circuit was turned off, causing each line to rise rapidly and fall slowly according to the input s weak pull-down circuitry. The fall time shows up as a change in the pulse width of the signal ready by the Xilinx. This change in pulse width is a function of capacitance, pulldown current, and input threshold. Capacitance was known from the different trace lengths, plus a gate input capacitance, which is the same for all inputs. The pull-down current is the same for all inputs including the two that are probed directly. The data was combined, and the Excel solver tool was used to find input thresholds for the 62 lines. This was repeated over different supply voltages and

  10. MARS code manual volume II: input requirements

    International Nuclear Information System (INIS)

    Chung, Bub Dong; Kim, Kyung Doo; Bae, Sung Won; Jeong, Jae Jun; Lee, Seung Wook; Hwang, Moon Kyu

    2010-02-01

    Korea Advanced Energy Research Institute (KAERI) conceived and started the development of MARS code with the main objective of producing a state-of-the-art realistic thermal hydraulic systems analysis code with multi-dimensional analysis capability. MARS achieves this objective by very tightly integrating the one dimensional RELAP5/MOD3 with the multi-dimensional COBRA-TF codes. The method of integration of the two codes is based on the dynamic link library techniques, and the system pressure equation matrices of both codes are implicitly integrated and solved simultaneously. In addition, the Equation-Of-State (EOS) for the light water was unified by replacing the EOS of COBRA-TF by that of the RELAP5. This input manual provides a complete list of input required to run MARS. The manual is divided largely into two parts, namely, the one-dimensional part and the multi-dimensional part. The inputs for auxiliary parts such as minor edit requests and graph formatting inputs are shared by the two parts and as such mixed input is possible. The overall structure of the input is modeled on the structure of the RELAP5 and as such the layout of the manual is very similar to that of the RELAP. This similitude to RELAP5 input is intentional as this input scheme will allow minimum modification between the inputs of RELAP5 and MARS3.1. MARS3.1 development team would like to express its appreciation to the RELAP5 Development Team and the USNRC for making this manual possible

  11. Total dose induced increase in input offset voltage in JFET input operational amplifiers

    International Nuclear Information System (INIS)

    Pease, R.L.; Krieg, J.; Gehlhausen, M.; Black, J.

    1999-01-01

    Four different types of commercial JFET input operational amplifiers were irradiated with ionizing radiation under a variety of test conditions. All experienced significant increases in input offset voltage (Vos). Microprobe measurement of the electrical characteristics of the de-coupled input JFETs demonstrates that the increase in Vos is a result of the mismatch of the degraded JFETs. (authors)

  12. Competition and convergence between auditory and cross-modal visual inputs to primary auditory cortical areas

    Science.gov (United States)

    Mao, Yu-Ting; Hua, Tian-Miao

    2011-01-01

    Sensory neocortex is capable of considerable plasticity after sensory deprivation or damage to input pathways, especially early in development. Although plasticity can often be restorative, sometimes novel, ectopic inputs invade the affected cortical area. Invading inputs from other sensory modalities may compromise the original function or even take over, imposing a new function and preventing recovery. Using ferrets whose retinal axons were rerouted into auditory thalamus at birth, we were able to examine the effect of varying the degree of ectopic, cross-modal input on reorganization of developing auditory cortex. In particular, we assayed whether the invading visual inputs and the existing auditory inputs competed for or shared postsynaptic targets and whether the convergence of input modalities would induce multisensory processing. We demonstrate that although the cross-modal inputs create new visual neurons in auditory cortex, some auditory processing remains. The degree of damage to auditory input to the medial geniculate nucleus was directly related to the proportion of visual neurons in auditory cortex, suggesting that the visual and residual auditory inputs compete for cortical territory. Visual neurons were not segregated from auditory neurons but shared target space even on individual target cells, substantially increasing the proportion of multisensory neurons. Thus spatial convergence of visual and auditory input modalities may be sufficient to expand multisensory representations. Together these findings argue that early, patterned visual activity does not drive segregation of visual and auditory afferents and suggest that auditory function might be compromised by converging visual inputs. These results indicate possible ways in which multisensory cortical areas may form during development and evolution. They also suggest that rehabilitative strategies designed to promote recovery of function after sensory deprivation or damage need to take into

  13. Input-output rearrangement of isolated converters

    DEFF Research Database (Denmark)

    Madsen, Mickey Pierre; Kovacevic, Milovan; Mønster, Jakob Døllner

    2015-01-01

    This paper presents a new way of rearranging the input and output of isolated converters. The new arrangement posses several advantages, as increased voltage range, higher power handling capabilities, reduced voltage stress and improved efficiency, for applications where galvanic isolation...

  14. Outsourcing, public Input provision and policy cooperation

    OpenAIRE

    Aronsson, Thomas; Koskela, Erkki

    2009-01-01

    This paper concerns public input provision as an instrument for redistribution under international outsourcing by using a model-economy comprising two countries, North and South, where firms in the North may outsource part of their low-skilled labor intensive production to the South. We consider two interrelated issues: (i) the incentives for each country to modify the provision of public input goods in response to international outsourcing, and (ii) whether international outsourcing justifie...

  15. HSTLBO: A hybrid algorithm based on Harmony Search and Teaching-Learning-Based Optimization for complex high-dimensional optimization problems.

    Directory of Open Access Journals (Sweden)

    Shouheng Tuo

    Full Text Available Harmony Search (HS and Teaching-Learning-Based Optimization (TLBO as new swarm intelligent optimization algorithms have received much attention in recent years. Both of them have shown outstanding performance for solving NP-Hard optimization problems. However, they also suffer dramatic performance degradation for some complex high-dimensional optimization problems. Through a lot of experiments, we find that the HS and TLBO have strong complementarity each other. The HS has strong global exploration power but low convergence speed. Reversely, the TLBO has much fast convergence speed but it is easily trapped into local search. In this work, we propose a hybrid search algorithm named HSTLBO that merges the two algorithms together for synergistically solving complex optimization problems using a self-adaptive selection strategy. In the HSTLBO, both HS and TLBO are modified with the aim of balancing the global exploration and exploitation abilities, where the HS aims mainly to explore the unknown regions and the TLBO aims to rapidly exploit high-precision solutions in the known regions. Our experimental results demonstrate better performance and faster speed than five state-of-the-art HS variants and show better exploration power than five good TLBO variants with similar run time, which illustrates that our method is promising in solving complex high-dimensional optimization problems. The experiment on portfolio optimization problems also demonstrate that the HSTLBO is effective in solving complex read-world application.

  16. Using random response input in Ibrahim Time Domain

    DEFF Research Database (Denmark)

    Olsen, Peter; Brincker, R.

    2013-01-01

    In this paper the time domain technique Ibrahim Time Domain (ITD) is used to analyze random time data. ITD is known to be a technique for identification of output only systems. The traditional formulation of ITD is claimed to be limited, when identifying closely spaced modes, because....... In this article it is showed that when using the modified ITD random time data can be analyzed. The application of the technique is displayed by a case study, with simulations and experimental data....... of the technique being Single Input Multiple Output (SIMO). It has earlier been showed that when modifying ITD with Toeplitz matrix averaging. Identification of time data with closely spaced modes is improved. In the traditional formulation of ITD the time data has to be free decays or impulse response functions...

  17. Cosmological dynamics of spatially flat Einstein-Gauss-Bonnet models in various dimensions: high-dimensional Λ-term case

    Energy Technology Data Exchange (ETDEWEB)

    Pavluchenko, Sergey A. [Universidade Federal do Maranhao (UFMA), Programa de Pos-Graduacao em Fisica, Sao Luis, Maranhao (Brazil)

    2017-08-15

    In this paper we perform a systematic study of spatially flat [(3+D)+1]-dimensional Einstein-Gauss-Bonnet cosmological models with Λ-term. We consider models that topologically are the product of two flat isotropic subspaces with different scale factors. One of these subspaces is three-dimensional and represents our space and the other is D-dimensional and represents extra dimensions. We consider no ansatz of the scale factors, which makes our results quite general. With both Einstein-Hilbert and Gauss-Bonnet contributions in play, D = 3 and the general D ≥ 4 cases have slightly different dynamics due to the different structure of the equations of motion. We analytically study the equations of motion in both cases and describe all possible regimes with special interest on the realistic regimes. Our analysis suggests that the only realistic regime is the transition from high-energy (Gauss-Bonnet) Kasner regime, which is the standard cosmological singularity in that case, to the anisotropic exponential regime with expanding three and contracting extra dimensions. Availability of this regime allows us to put a constraint on the value of Gauss-Bonnet coupling α and the Λ-term - this regime appears in two regions on the (α, Λ) plane: α < 0, Λ > 0, αΛ ≤ -3/2 and α > 0, αΛ ≤ (3D{sup 2} - 7D + 6)/(4D(D-1)), including the entire Λ < 0 region. The obtained bounds are confronted with the restrictions on α and Λ from other considerations, like causality, entropy-to-viscosity ratio in AdS/CFT and others. Joint analysis constrains (α, Λ) even further: α > 0, D ≥ 2 with (3D{sup 2} - 7D + 6)/(4D(D-1)) ≥ αΛ ≥ -(D+2)(D+3)(D{sup 2} + 5D + 12)/(8(D{sup 2} + 3D + 6){sup 2}). (orig.)

  18. Six axis force feedback input device

    Science.gov (United States)

    Ohm, Timothy (Inventor)

    1998-01-01

    The present invention is a low friction, low inertia, six-axis force feedback input device comprising an arm with double-jointed, tendon-driven revolute joints, a decoupled tendon-driven wrist, and a base with encoders and motors. The input device functions as a master robot manipulator of a microsurgical teleoperated robot system including a slave robot manipulator coupled to an amplifier chassis, which is coupled to a control chassis, which is coupled to a workstation with a graphical user interface. The amplifier chassis is coupled to the motors of the master robot manipulator and the control chassis is coupled to the encoders of the master robot manipulator. A force feedback can be applied to the input device and can be generated from the slave robot to enable a user to operate the slave robot via the input device without physically viewing the slave robot. Also, the force feedback can be generated from the workstation to represent fictitious forces to constrain the input device's control of the slave robot to be within imaginary predetermined boundaries.

  19. Computer Generated Inputs for NMIS Processor Verification

    International Nuclear Information System (INIS)

    J. A. Mullens; J. E. Breeding; J. A. McEvers; R. W. Wysor; L. G. Chiang; J. R. Lenarduzzi; J. T. Mihalczo; J. K. Mattingly

    2001-01-01

    Proper operation of the Nuclear Identification Materials System (NMIS) processor can be verified using computer-generated inputs [BIST (Built-In-Self-Test)] at the digital inputs. Preselected sequences of input pulses to all channels with known correlation functions are compared to the output of the processor. These types of verifications have been utilized in NMIS type correlation processors at the Oak Ridge National Laboratory since 1984. The use of this test confirmed a malfunction in a NMIS processor at the All-Russian Scientific Research Institute of Experimental Physics (VNIIEF) in 1998. The NMIS processor boards were returned to the U.S. for repair and subsequently used in NMIS passive and active measurements with Pu at VNIIEF in 1999

  20. Key Frame Extraction in the Summary Space.

    Science.gov (United States)

    Li, Xuelong; Zhao, Bin; Lu, Xiaoqiang; Xuelong Li; Bin Zhao; Xiaoqiang Lu; Lu, Xiaoqiang; Li, Xuelong; Zhao, Bin

    2018-06-01

    Key frame extraction is an efficient way to create the video summary which helps users obtain a quick comprehension of the video content. Generally, the key frames should be representative of the video content, meanwhile, diverse to reduce the redundancy. Based on the assumption that the video data are near a subspace of a high-dimensional space, a new approach, named as key frame extraction in the summary space, is proposed for key frame extraction in this paper. The proposed approach aims to find the representative frames of the video and filter out similar frames from the representative frame set. First of all, the video data are mapped to a high-dimensional space, named as summary space. Then, a new representation is learned for each frame by analyzing the intrinsic structure of the summary space. Specifically, the learned representation can reflect the representativeness of the frame, and is utilized to select representative frames. Next, the perceptual hash algorithm is employed to measure the similarity of representative frames. As a result, the key frame set is obtained after filtering out similar frames from the representative frame set. Finally, the video summary is constructed by assigning the key frames in temporal order. Additionally, the ground truth, created by filtering out similar frames from human-created summaries, is utilized to evaluate the quality of the video summary. Compared with several traditional approaches, the experimental results on 80 videos from two datasets indicate the superior performance of our approach.

  1. Decimated Input Ensembles for Improved Generalization

    Science.gov (United States)

    Tumer, Kagan; Oza, Nikunj C.; Norvig, Peter (Technical Monitor)

    1999-01-01

    Recently, many researchers have demonstrated that using classifier ensembles (e.g., averaging the outputs of multiple classifiers before reaching a classification decision) leads to improved performance for many difficult generalization problems. However, in many domains there are serious impediments to such "turnkey" classification accuracy improvements. Most notable among these is the deleterious effect of highly correlated classifiers on the ensemble performance. One particular solution to this problem is generating "new" training sets by sampling the original one. However, with finite number of patterns, this causes a reduction in the training patterns each classifier sees, often resulting in considerably worsened generalization performance (particularly for high dimensional data domains) for each individual classifier. Generally, this drop in the accuracy of the individual classifier performance more than offsets any potential gains due to combining, unless diversity among classifiers is actively promoted. In this work, we introduce a method that: (1) reduces the correlation among the classifiers; (2) reduces the dimensionality of the data, thus lessening the impact of the 'curse of dimensionality'; and (3) improves the classification performance of the ensemble.

  2. Harmonize input selection for sediment transport prediction

    Science.gov (United States)

    Afan, Haitham Abdulmohsin; Keshtegar, Behrooz; Mohtar, Wan Hanna Melini Wan; El-Shafie, Ahmed

    2017-09-01

    In this paper, three modeling approaches using a Neural Network (NN), Response Surface Method (RSM) and response surface method basis Global Harmony Search (GHS) are applied to predict the daily time series suspended sediment load. Generally, the input variables for forecasting the suspended sediment load are manually selected based on the maximum correlations of input variables in the modeling approaches based on NN and RSM. The RSM is improved to select the input variables by using the errors terms of training data based on the GHS, namely as response surface method and global harmony search (RSM-GHS) modeling method. The second-order polynomial function with cross terms is applied to calibrate the time series suspended sediment load with three, four and five input variables in the proposed RSM-GHS. The linear, square and cross corrections of twenty input variables of antecedent values of suspended sediment load and water discharge are investigated to achieve the best predictions of the RSM based on the GHS method. The performances of the NN, RSM and proposed RSM-GHS including both accuracy and simplicity are compared through several comparative predicted and error statistics. The results illustrated that the proposed RSM-GHS is as uncomplicated as the RSM but performed better, where fewer errors and better correlation was observed (R = 0.95, MAE = 18.09 (ton/day), RMSE = 25.16 (ton/day)) compared to the ANN (R = 0.91, MAE = 20.17 (ton/day), RMSE = 33.09 (ton/day)) and RSM (R = 0.91, MAE = 20.06 (ton/day), RMSE = 31.92 (ton/day)) for all types of input variables.

  3. Shaped input distributions for structural damage localization

    DEFF Research Database (Denmark)

    Ulriksen, Martin Dalgaard; Bernal, Dionisio; Damkilde, Lars

    2018-01-01

    localization method is cast that operates on the premise of shaping inputs—whose spatial distribution is fixed—by use of a model, such that these inputs, in one structural subdomain at a time, suppress certain steady-state vibration quantities (depending on the type of damage one seeks to interrogate for......). Accordingly, damage is localized when the vibration signature induced by the shaped inputs in the damaged state corresponds to that in the reference state, hereby implying that the approach does not point directly to damage. Instead, it operates with interrogation based on postulated damage patterns...

  4. A parallel input composite transimpedance amplifier

    Science.gov (United States)

    Kim, D. J.; Kim, C.

    2018-01-01

    A new approach to high performance current to voltage preamplifier design is presented. The design using multiple operational amplifiers (op-amps) has a parasitic capacitance compensation network and a composite amplifier topology for fast, precision, and low noise performance. The input stage consisting of a parallel linked JFET op-amps and a high-speed bipolar junction transistor (BJT) gain stage driving the output in the composite amplifier topology, cooperating with the capacitance compensation feedback network, ensures wide bandwidth stability in the presence of input capacitance above 40 nF. The design is ideal for any two-probe measurement, including high impedance transport and scanning tunneling microscopy measurements.

  5. Nuclear reaction inputs based on effective interactions

    Energy Technology Data Exchange (ETDEWEB)

    Hilaire, S.; Peru, S.; Dubray, N.; Dupuis, M.; Bauge, E. [CEA, DAM, DIF, Arpajon (France); Goriely, S. [Universite Libre de Bruxelles, Institut d' Astronomie et d' Astrophysique, CP-226, Brussels (Belgium)

    2016-11-15

    Extensive nuclear structure studies have been performed for decades using effective interactions as sole input. They have shown a remarkable ability to describe rather accurately many types of nuclear properties. In the early 2000 s, a major effort has been engaged to produce nuclear reaction input data out of the Gogny interaction, in order to challenge its quality also with respect to nuclear reaction observables. The status of this project, well advanced today thanks to the use of modern computers as well as modern nuclear reaction codes, is reviewed and future developments are discussed. (orig.)

  6. Simulation of a Multidimensional Input Quantum Perceptron

    Science.gov (United States)

    Yamamoto, Alexandre Y.; Sundqvist, Kyle M.; Li, Peng; Harris, H. Rusty

    2018-06-01

    In this work, we demonstrate the improved data separation capabilities of the Multidimensional Input Quantum Perceptron (MDIQP), a fundamental cell for the construction of more complex Quantum Artificial Neural Networks (QANNs). This is done by using input controlled alterations of ancillary qubits in combination with phase estimation and learning algorithms. The MDIQP is capable of processing quantum information and classifying multidimensional data that may not be linearly separable, extending the capabilities of the classical perceptron. With this powerful component, we get much closer to the achievement of a feedforward multilayer QANN, which would be able to represent and classify arbitrary sets of data (both quantum and classical).

  7. Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

    Directory of Open Access Journals (Sweden)

    Nils Ternès

    2017-05-01

    Full Text Available Abstract Background Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. Despite the methodological framework for the development and validation of prediction models in a high-dimensional setting is getting more and more established, no clear guidance exists yet on how to estimate expected survival probabilities in a penalized model with biomarker-by-treatment interactions. Methods Based on a parsimonious biomarker selection in a penalized high-dimensional Cox model (lasso or adaptive lasso, we propose a unified framework to: estimate internally the predictive accuracy metrics of the developed model (using double cross-validation; estimate the individual survival probabilities at a given timepoint; construct confidence intervals thereof (analytical or bootstrap; and visualize them graphically (pointwise or smoothed with spline. We compared these strategies through a simulation study covering scenarios with or without biomarker effects. We applied the strategies to a large randomized phase III clinical trial that evaluated the effect of adding trastuzumab to chemotherapy in 1574 early breast cancer patients, for which the expression of 462 genes was measured. Results In our simulations, penalized regression models using the adaptive lasso estimated the survival probability of new patients with low bias and standard error; bootstrapped confidence intervals had empirical coverage probability close to the nominal level across very different scenarios. The double cross-validation performed on the training data set closely mimicked the predictive accuracy of the selected models in external validation data. We also propose a useful visual representation of the expected survival probabilities using splines. In the breast cancer trial, the adaptive lasso penalty selected a prediction model with 4

  8. Normed kernel function-based fuzzy possibilistic C-means (NKFPCM) algorithm for high-dimensional breast cancer database classification with feature selection is based on Laplacian Score

    Science.gov (United States)

    Lestari, A. W.; Rustam, Z.

    2017-07-01

    In the last decade, breast cancer has become the focus of world attention as this disease is one of the primary leading cause of death for women. Therefore, it is necessary to have the correct precautions and treatment. In previous studies, Fuzzy Kennel K-Medoid algorithm has been used for multi-class data. This paper proposes an algorithm to classify the high dimensional data of breast cancer using Fuzzy Possibilistic C-means (FPCM) and a new method based on clustering analysis using Normed Kernel Function-Based Fuzzy Possibilistic C-Means (NKFPCM). The objective of this paper is to obtain the best accuracy in classification of breast cancer data. In order to improve the accuracy of the two methods, the features candidates are evaluated using feature selection, where Laplacian Score is used. The results show the comparison accuracy and running time of FPCM and NKFPCM with and without feature selection.

  9. 7 CFR 3430.907 - Stakeholder input.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Stakeholder input. 3430.907 Section 3430.907 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE COMPETITIVE AND NONCOMPETITIVE NON-FORMULA FEDERAL...

  10. A summary of WIMSD4 input option

    International Nuclear Information System (INIS)

    Halsall, M.J.

    1980-07-01

    A description is given of all the available input data options in the ICL 4/70 and IBM 370 versions of WIMSD4, with little more than a reference where there is already adequate documentation but with rather more detail where no such documentation exists. (author)

  11. Hydrogen Generation Rate Model Calculation Input Data

    International Nuclear Information System (INIS)

    KUFAHL, M.A.

    2000-01-01

    This report documents the procedures and techniques utilized in the collection and analysis of analyte input data values in support of the flammable gas hazard safety analyses. This document represents the analyses of data current at the time of its writing and does not account for data available since then

  12. Fast Markov chain Monte Carlo sampling for sparse Bayesian inference in high-dimensional inverse problems using L1-type priors

    International Nuclear Information System (INIS)

    Lucka, Felix

    2012-01-01

    Sparsity has become a key concept for solving of high-dimensional inverse problems using variational regularization techniques. Recently, using similar sparsity-constraints in the Bayesian framework for inverse problems by encoding them in the prior distribution has attracted attention. Important questions about the relation between regularization theory and Bayesian inference still need to be addressed when using sparsity promoting inversion. A practical obstacle for these examinations is the lack of fast posterior sampling algorithms for sparse, high-dimensional Bayesian inversion. Accessing the full range of Bayesian inference methods requires being able to draw samples from the posterior probability distribution in a fast and efficient way. This is usually done using Markov chain Monte Carlo (MCMC) sampling algorithms. In this paper, we develop and examine a new implementation of a single component Gibbs MCMC sampler for sparse priors relying on L1-norms. We demonstrate that the efficiency of our Gibbs sampler increases when the level of sparsity or the dimension of the unknowns is increased. This property is contrary to the properties of the most commonly applied Metropolis–Hastings (MH) sampling schemes. We demonstrate that the efficiency of MH schemes for L1-type priors dramatically decreases when the level of sparsity or the dimension of the unknowns is increased. Practically, Bayesian inversion for L1-type priors using MH samplers is not feasible at all. As this is commonly believed to be an intrinsic feature of MCMC sampling, the performance of our Gibbs sampler also challenges common beliefs about the applicability of sample based Bayesian inference. (paper)

  13. Seizure-Onset Mapping Based on Time-Variant Multivariate Functional Connectivity Analysis of High-Dimensional Intracranial EEG: A Kalman Filter Approach.

    Science.gov (United States)

    Lie, Octavian V; van Mierlo, Pieter

    2017-01-01

    The visual interpretation of intracranial EEG (iEEG) is the standard method used in complex epilepsy surgery cases to map the regions of seizure onset targeted for resection. Still, visual iEEG analysis is labor-intensive and biased due to interpreter dependency. Multivariate parametric functional connectivity measures using adaptive autoregressive (AR) modeling of the iEEG signals based on the Kalman filter algorithm have been used successfully to localize the electrographic seizure onsets. Due to their high computational cost, these methods have been applied to a limited number of iEEG time-series (Kalman filter implementations, a well-known multivariate adaptive AR model (Arnold et al. 1998) and a simplified, computationally efficient derivation of it, for their potential application to connectivity analysis of high-dimensional (up to 192 channels) iEEG data. When used on simulated seizures together with a multivariate connectivity estimator, the partial directed coherence, the two AR models were compared for their ability to reconstitute the designed seizure signal connections from noisy data. Next, focal seizures from iEEG recordings (73-113 channels) in three patients rendered seizure-free after surgery were mapped with the outdegree, a graph-theory index of outward directed connectivity. Simulation results indicated high levels of mapping accuracy for the two models in the presence of low-to-moderate noise cross-correlation. Accordingly, both AR models correctly mapped the real seizure onset to the resection volume. This study supports the possibility of conducting fully data-driven multivariate connectivity estimations on high-dimensional iEEG datasets using the Kalman filter approach.

  14. Leaders’ receptivity to subordinates’ creative input: the role of achievement goals and composition of creative input

    NARCIS (Netherlands)

    Sijbom, R.B.L.; Janssen, O.; van Yperen, N.W.

    2015-01-01

    We identified leaders’ achievement goals and composition of creative input as important factors that can clarify when and why leaders are receptive to, and supportive of, subordinates’ creative input. As hypothesized, in two experimental studies, we found that relative to mastery goal leaders,

  15. Do efficiency scores depend on input mix?

    DEFF Research Database (Denmark)

    Asmild, Mette; Hougaard, Jens Leth; Kronborg, Dorte

    2013-01-01

    In this paper we examine the possibility of using the standard Kruskal-Wallis (KW) rank test in order to evaluate whether the distribution of efficiency scores resulting from Data Envelopment Analysis (DEA) is independent of the input (or output) mix of the observations. Since the DEA frontier...... is estimated, many standard assumptions for evaluating the KW test statistic are violated. Therefore, we propose to explore its statistical properties by the use of simulation studies. The simulations are performed conditional on the observed input mixes. The method, unlike existing approaches...... the assumption of mix independence is rejected the implication is that it, for example, is impossible to determine whether machine intensive project are more or less efficient than labor intensive projects....

  16. Application of computer voice input/output

    International Nuclear Information System (INIS)

    Ford, W.; Shirk, D.G.

    1981-01-01

    The advent of microprocessors and other large-scale integration (LSI) circuits is making voice input and output for computers and instruments practical; specialized LSI chips for speech processing are appearing on the market. Voice can be used to input data or to issue instrument commands; this allows the operator to engage in other tasks, move about, and to use standard data entry systems. Voice synthesizers can generate audible, easily understood instructions. Using voice characteristics, a control system can verify speaker identity for security purposes. Two simple voice-controlled systems have been designed at Los Alamos for nuclear safeguards applicaations. Each can easily be expanded as time allows. The first system is for instrument control that accepts voice commands and issues audible operator prompts. The second system is for access control. The speaker's voice is used to verify his identity and to actuate external devices

  17. Sensory Synergy as Environmental Input Integration

    Directory of Open Access Journals (Sweden)

    Fady eAlnajjar

    2015-01-01

    Full Text Available The development of a method to feed proper environmental inputs back to the central nervous system (CNS remains one of the challenges in achieving natural movement when part of the body is replaced with an artificial device. Muscle synergies are widely accepted as a biologically plausible interpretation of the neural dynamics between the CNS and the muscular system. Yet the sensorineural dynamics of environmental feedback to the CNS has not been investigated in detail. In this study, we address this issue by exploring the concept of sensory synergy. In contrast to muscle synergy, we hypothesize that sensory synergy plays an essential role in integrating the overall environmental inputs to provide low-dimensional information to the CNS. We assume that sensor synergy and muscle synergy communicate using these low-dimensional signals. To examine our hypothesis, we conducted posture control experiments involving lateral disturbance with 9 healthy participants. Proprioceptive information represented by the changes on muscle lengths were estimated by using the musculoskeletal model analysis software SIMM. Changes on muscles lengths were then used to compute sensory synergies. The experimental results indicate that the environmental inputs were translated into the two dimensional signals and used to move the upper limb to the desired position immediately after the lateral disturbance. Participants who showed high skill in posture control were found to be likely to have a strong correlation between sensory and muscle signaling as well as high coordination between the utilized sensory synergies. These results suggest the importance of integrating environmental inputs into suitable low-dimensional signals before providing them to the CNS. This mechanism should be essential when designing the prosthesis’ sensory system to make the controller simpler

  18. Sensory synergy as environmental input integration.

    Science.gov (United States)

    Alnajjar, Fady; Itkonen, Matti; Berenz, Vincent; Tournier, Maxime; Nagai, Chikara; Shimoda, Shingo

    2014-01-01

    The development of a method to feed proper environmental inputs back to the central nervous system (CNS) remains one of the challenges in achieving natural movement when part of the body is replaced with an artificial device. Muscle synergies are widely accepted as a biologically plausible interpretation of the neural dynamics between the CNS and the muscular system. Yet the sensorineural dynamics of environmental feedback to the CNS has not been investigated in detail. In this study, we address this issue by exploring the concept of sensory synergy. In contrast to muscle synergy, we hypothesize that sensory synergy plays an essential role in integrating the overall environmental inputs to provide low-dimensional information to the CNS. We assume that sensor synergy and muscle synergy communicate using these low-dimensional signals. To examine our hypothesis, we conducted posture control experiments involving lateral disturbance with nine healthy participants. Proprioceptive information represented by the changes on muscle lengths were estimated by using the musculoskeletal model analysis software SIMM. Changes on muscles lengths were then used to compute sensory synergies. The experimental results indicate that the environmental inputs were translated into the two dimensional signals and used to move the upper limb to the desired position immediately after the lateral disturbance. Participants who showed high skill in posture control were found to be likely to have a strong correlation between sensory and muscle signaling as well as high coordination between the utilized sensory synergies. These results suggest the importance of integrating environmental inputs into suitable low-dimensional signals before providing them to the CNS. This mechanism should be essential when designing the prosthesis' sensory system to make the controller simpler.

  19. PREP-45, Input Preparation for CITATION-2

    International Nuclear Information System (INIS)

    Ramalho Carlos, C.A.

    1995-01-01

    1 - Description of program or function: A Fortran program has been created, which saves much effort in preparing sections 004 (intervals in the coordinates) and 005 (zone numbers) of the input data file for the multigroup theory code CITATION (version CITATION-2, NESC0387/09), particularly when a thin complicated mesh is used. 2 - Method of solution: A domain is defined for CITATION calculations through specifying its sub-domains (e.g. graphite, lead, beryllium, water and fuel sub-domains) in a compact and simple way. An independent and previous geometrical specification is made of the various types of elements which are envisaged to constitute the contents of the reactor core grid positions. Then the load table for the configuration is input and scanned throughout, thus enabling the geometric mesh description to be produced (section 004). Also the zone placement (section 005) is achieved by means of element description subroutines for the different types of element (which may require appropriate but simple changes in the actual cases). The output of PREP45 is directly obtained in a format which is compatible with CITATION-2 input. 3 - Restrictions on the complexity of the problem: Only rectangular two-dimensional Cartesian coordinates are considered. A maximum of 12 sub-domains in the x direction (18 in the y direction) and up to 8 distinct element types are considered in this version. Other limitations exist which can nevertheless be overcome with simple changes in the source program

  20. Molecular structure input on the web

    Directory of Open Access Journals (Sweden)

    Ertl Peter

    2010-02-01

    Full Text Available Abstract A molecule editor, that is program for input and editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. This review focuses on a special type of molecule editors, namely those that are used for molecule structure input on the web. Scientific computing is now moving more and more in the direction of web services and cloud computing, with servers scattered all around the Internet. Thus a web browser has become the universal scientific user interface, and a tool to edit molecules directly within the web browser is essential. The review covers a history of web-based structure input, starting with simple text entry boxes and early molecule editors based on clickable maps, before moving to the current situation dominated by Java applets. One typical example - the popular JME Molecule Editor - will be described in more detail. Modern Ajax server-side molecule editors are also presented. And finally, the possible future direction of web-based molecule editing, based on technologies like JavaScript and Flash, is discussed.

  1. Genetic algorithm based input selection for a neural network function approximator with applications to SSME health monitoring

    Science.gov (United States)

    Peck, Charles C.; Dhawan, Atam P.; Meyer, Claudia M.

    1991-01-01

    A genetic algorithm is used to select the inputs to a neural network function approximator. In the application considered, modeling critical parameters of the space shuttle main engine (SSME), the functional relationship between measured parameters is unknown and complex. Furthermore, the number of possible input parameters is quite large. Many approaches have been used for input selection, but they are either subjective or do not consider the complex multivariate relationships between parameters. Due to the optimization and space searching capabilities of genetic algorithms they were employed to systematize the input selection process. The results suggest that the genetic algorithm can generate parameter lists of high quality without the explicit use of problem domain knowledge. Suggestions for improving the performance of the input selection process are also provided.

  2. Declaration of input sources in scientific research: should this practice be incorporated to organizational information management?

    Directory of Open Access Journals (Sweden)

    José Osvaldo De Sordi

    Full Text Available This research studies the declaration of input sources for research in scientific communications, more specifically, whether this practice of the academy may be considered a good example to be followed by organizations. Seven hypotheses address two dimensions of input sources: origin (primary or secondary and nature (data or information. It appears that the declaration of research inputs in the academy is problematic, mostly incomplete or inaccurate. This does not reduce the importance of this practice; it simply indicates that the academy should not be considered a privileged space, with wide dominance and practice excellence. Nevertheless, the information environment of organizations can learn and benefit from the experience of the scientific academy. From the analyses of the research sample, a set of procedures has been developed, which allowed organizational analysts and researchers to elaborate a complete and accurate analysis of the input sources to be declared in organizational or scientific communication.

  3. Input preshaping with frequency domain information for flexible-link manipulator control

    Science.gov (United States)

    Tzes, Anthony; Englehart, Matthew J.; Yurkovich, Stephen

    1989-01-01

    The application of an input preshaping scheme to flexible manipulators is considered. The resulting control corresponds to a feedforward term that convolves in real-time the desired reference input with a sequence of impulses and produces a vibration free output. The robustness of the algorithm with respect to injected disturbances and modal frequency variations is not satisfactory and can be improved by convolving the input with a longer sequence of impulses. The incorporation of the preshaping scheme to a closed-loop plant, using acceleration feedback, offers satisfactory disturbance rejection due to feedback and cancellation of the flexible mode effects due to the preshaping. A frequency domain identification scheme is used to estimate the modal frequencies on-line and subsequently update the spacing between the impulses. The combined adaptive input preshaping scheme provides the fastest possible slew that results in a vibration free output.

  4. Labour input in construction of composite structures of the Balakovo NPP reactor compartment

    International Nuclear Information System (INIS)

    Alasyuk, G.Ya.

    1988-01-01

    Technical-economical results achieved when constructing the Balakovo NPP second unit reactor compartment structures are presented. The obtained data analysis shows that in the case of building the walls of non-sealed reactor compartment section in the form of composite structures the major part of labour input requirements (54-59%) falls at works on production and mounting of these structures, performed at auxiliary plants. Labour input for works performed the construction (unit-cell and space frame mounting, preparation of units for concreting, joint sealing, concrete placement) make up 41-46%, and labour input for enlarged unit-cell mounting make up 8%. Labour input per 1 m 3 of the wall structure with 0.6 and 0.9 m thicness in the monolith option are respectively by 19 an 23% higher than the same indices for composite

  5. Impact of Reducing Polarimetric SAR Input on the Uncertainty of Crop Classifications Based on the Random Forests Algorithm

    DEFF Research Database (Denmark)

    Loosvelt, Lien; Peters, Jan; Skriver, Henning

    2012-01-01

    Although the use of multidate polarimetric synthetic aperture radar (SAR) data for highly accurate land cover classification has been acknowledged in the literature, the high dimensionality of the data set remains a major issue. This study presents two different strategies to reduce the number...... acquired by the Danish EMISAR on four dates within the period April to July in 1998. The predictive capacity of each feature is analyzed by the importance score generated by random forests (RF). Results show that according to the variation in importance score over time, a distinction can be made between...... general and specific features for crop classification. Based on the importance ranking, features are gradually removed from the single-date data sets in order to construct several multidate data sets with decreasing dimensionality. In the accuracy-oriented and efficiency-oriented reduction, the input...

  6. Modelling Analysis of Forestry Input-Output Elasticity in China

    Directory of Open Access Journals (Sweden)

    Guofeng Wang

    2016-01-01

    Full Text Available Based on an extended economic model and space econometrics, this essay analyzed the spatial distributions and interdependent relationships of the production of forestry in China; also the input-output elasticity of forestry production were calculated. Results figure out there exists significant spatial correlation in forestry production in China. Spatial distribution is mainly manifested as spatial agglomeration. The output elasticity of labor force is equal to 0.6649, and that of capital is equal to 0.8412. The contribution of land is significantly negative. Labor and capital are the main determinants for the province-level forestry production in China. Thus, research on the province-level forestry production should not ignore the spatial effect. The policy-making process should take into consideration the effects between provinces on the production of forestry. This study provides some scientific technical support for forestry production.

  7. The Generalization Complexity Measure for Continuous Input Data

    Directory of Open Access Journals (Sweden)

    Iván Gómez

    2014-01-01

    defined in Boolean space, quantifies the complexity of data in relationship to the prediction accuracy that can be expected when using a supervised classifier like a neural network, SVM, and so forth. We first extend the original measure for its use with continuous functions to later on, using an approach based on the use of the set of Walsh functions, consider the case of having a finite number of data points (inputs/outputs pairs, that is, usually the practical case. Using a set of trigonometric functions a model that gives a relationship between the size of the hidden layer of a neural network and the complexity is constructed. Finally, we demonstrate the application of the introduced complexity measure, by using the generated model, to the problem of estimating an adequate neural network architecture for real-world data sets.

  8. Safe Exploration of State and Action Spaces in Reinforcement Learning

    OpenAIRE

    Garcia, Javier; Fernandez, Fernando

    2014-01-01

    In this paper, we consider the important problem of safe exploration in reinforcement learning. While reinforcement learning is well-suited to domains with complex transition dynamics and high-dimensional state-action spaces, an additional challenge is posed by the need for safe and efficient exploration. Traditional exploration techniques are not particularly useful for solving dangerous tasks, where the trial and error process may lead to the selection of actions whose execution in some sta...

  9. Tangent map intermittency as an approximate analysis of intermittency in a high dimensional fully stochastic dynamical system: The Tangled Nature model.

    Science.gov (United States)

    Diaz-Ruelas, Alvaro; Jeldtoft Jensen, Henrik; Piovani, Duccio; Robledo, Alberto

    2016-12-01

    It is well known that low-dimensional nonlinear deterministic maps close to a tangent bifurcation exhibit intermittency and this circumstance has been exploited, e.g., by Procaccia and Schuster [Phys. Rev. A 28, 1210 (1983)], to develop a general theory of 1/f spectra. This suggests it is interesting to study the extent to which the behavior of a high-dimensional stochastic system can be described by such tangent maps. The Tangled Nature (TaNa) Model of evolutionary ecology is an ideal candidate for such a study, a significant model as it is capable of reproducing a broad range of the phenomenology of macroevolution and ecosystems. The TaNa model exhibits strong intermittency reminiscent of punctuated equilibrium and, like the fossil record of mass extinction, the intermittency in the model is found to be non-stationary, a feature typical of many complex systems. We derive a mean-field version for the evolution of the likelihood function controlling the reproduction of species and find a local map close to tangency. This mean-field map, by our own local approximation, is able to describe qualitatively only one episode of the intermittent dynamics of the full TaNa model. To complement this result, we construct a complete nonlinear dynamical system model consisting of successive tangent bifurcations that generates time evolution patterns resembling those of the full TaNa model in macroscopic scales. The switch from one tangent bifurcation to the next in the sequences produced in this model is stochastic in nature, based on criteria obtained from the local mean-field approximation, and capable of imitating the changing set of types of species and total population in the TaNa model. The model combines full deterministic dynamics with instantaneous parameter random jumps at stochastically drawn times. In spite of the limitations of our approach, which entails a drastic collapse of degrees of freedom, the description of a high-dimensional model system in terms of a low

  10. A two-input sliding-mode controller for a planar arm actuated by four pneumatic muscle groups.

    Science.gov (United States)

    Lilly, John H; Quesada, Peter M

    2004-09-01

    Multiple-input sliding-mode techniques are applied to a planar arm actuated by four groups of pneumatic muscle (PM) actuators in opposing pair configuration. The control objective is end-effector tracking of a desired path in Cartesian space. The inputs to the system are commanded input pressure differentials for the two opposing PM groups. An existing model for the muscle is incorporated into the arm equations of motion to arrive at a two-input, two-output nonlinear model of the planar arm that is affine in the input and, therefore, suitable for sliding-mode techniques. Relationships between static input pressures are derived for suitable arm behavior in the absence of a control signal. Simulation studies are reported.

  11. Response of spiking neurons to correlated inputs

    International Nuclear Information System (INIS)

    Moreno, Ruben; Rocha, Jaime de la; Renart, Alfonso; Parga, Nestor

    2002-01-01

    The effect of a temporally correlated afferent current on the firing rate of a leaky integrate-and-fire neuron is studied. This current is characterized in terms of rates, autocorrelations, and cross correlations, and correlation time scale τ c of excitatory and inhibitory inputs. The output rate ν out is calculated in the Fokker-Planck formalism in the limit of both small and large τ c compared to the membrane time constant τ of the neuron. By simulations we check the analytical results, provide an interpolation valid for all τ c , and study the neuron's response to rapid changes in the correlation magnitude

  12. Culture Input in Foreign Language Teaching

    Institute of Scientific and Technical Information of China (English)

    胡晶

    2009-01-01

    Language and culture are highly interrelated, that is to say, language is not only the carrier of culture but it is also restricted by culture. Therefore, foreign language teaching aiming at cultivate students' intercultural communication should take culture differences into consideration. In this paper, the relationship between language and culture will be discussed. Then I will illustrate the importance of intercultural communication. Finally, according to the present situation of foreign language teaching in China, several strategies for cultural input in and out of class will be suggested.

  13. Mobile gaze input system for pervasive interaction

    DEFF Research Database (Denmark)

    2017-01-01

    feedback to the user in response to the received command input. The unit provides feedback to the user on how to position the mobile unit in front of his eyes. The gaze tracking unit interacts with one or more controlled devices via wireless or wired communications. Example devices include a lock......, a thermostat, a light or a TV. The connection between the gaze tracking unit may be temporary or longer-lasting. The gaze tracking unit may detect features of the eye that provide information about the identity of the user....

  14. Flexible input, dazzling output with IBM i

    CERN Document Server

    Victória-Pereira, Rafael

    2014-01-01

    Link your IBM i system to the modern business server world! This book presents easier and more flexible ways to get data into your IBM i system, along with rather surprising methods to export and present the vital business data it contains. You'll learn how to automate file transfers, seamlessly connect PC applications with your RPG programs, and much more. Input operations will become more flexible and user-proof, with self-correcting import processes and direct file transfers that require a minimum of user intervention. Also learn novel ways to present information: your DB2 data will look gr

  15. The Importance of Input and Interaction in SLA

    Institute of Scientific and Technical Information of China (English)

    党春花

    2009-01-01

    As is known to us, input and interaction play the crucial roles in second language acquisition (SLA). Different linguistic schools have different explanations to input and interaction Behaviorist theories hold a view that input is composed of stimuli and response, putting more emphasis on the importance of input, while mentalist theories find input is a necessary condition to SLA, not a sufficient condition. At present, social interaction theories, which is one type of cognitive linguistics, suggests that besides input, interaction is also essential to language acquisition. Then, this essay will discuss how input and interaction result in SLA.

  16. A new method for automated high-dimensional lesion segmentation evaluated in vascular injury and applied to the human occipital lobe.

    Science.gov (United States)

    Mah, Yee-Haur; Jager, Rolf; Kennard, Christopher; Husain, Masud; Nachev, Parashkev

    2014-07-01

    Making robust inferences about the functional neuroanatomy of the brain is critically dependent on experimental techniques that examine the consequences of focal loss of brain function. Unfortunately, the use of the most comprehensive such technique-lesion-function mapping-is complicated by the need for time-consuming and subjective manual delineation of the lesions, greatly limiting the practicability of the approach. Here we exploit a recently-described general measure of statistical anomaly, zeta, to devise a fully-automated, high-dimensional algorithm for identifying the parameters of lesions within a brain image given a reference set of normal brain images. We proceed to evaluate such an algorithm in the context of diffusion-weighted imaging of the commonest type of lesion used in neuroanatomical research: ischaemic damage. Summary performance metrics exceed those previously published for diffusion-weighted imaging and approach the current gold standard-manual segmentation-sufficiently closely for fully-automated lesion-mapping studies to become a possibility. We apply the new method to 435 unselected images of patients with ischaemic stroke to derive a probabilistic map of the pattern of damage in lesions involving the occipital lobe, demonstrating the variation of anatomical resolvability of occipital areas so as to guide future lesion-function studies of the region. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Comparing the accuracy of high-dimensional neural network potentials and the systematic molecular fragmentation method: A benchmark study for all-trans alkanes

    International Nuclear Information System (INIS)

    Gastegger, Michael; Kauffmann, Clemens; Marquetand, Philipp; Behler, Jörg

    2016-01-01

    Many approaches, which have been developed to express the potential energy of large systems, exploit the locality of the atomic interactions. A prominent example is the fragmentation methods in which the quantum chemical calculations are carried out for overlapping small fragments of a given molecule that are then combined in a second step to yield the system’s total energy. Here we compare the accuracy of the systematic molecular fragmentation approach with the performance of high-dimensional neural network (HDNN) potentials introduced by Behler and Parrinello. HDNN potentials are similar in spirit to the fragmentation approach in that the total energy is constructed as a sum of environment-dependent atomic energies, which are derived indirectly from electronic structure calculations. As a benchmark set, we use all-trans alkanes containing up to eleven carbon atoms at the coupled cluster level of theory. These molecules have been chosen because they allow to extrapolate reliable reference energies for very long chains, enabling an assessment of the energies obtained by both methods for alkanes including up to 10 000 carbon atoms. We find that both methods predict high-quality energies with the HDNN potentials yielding smaller errors with respect to the coupled cluster reference.

  18. Comparing the accuracy of high-dimensional neural network potentials and the systematic molecular fragmentation method: A benchmark study for all-trans alkanes

    Energy Technology Data Exchange (ETDEWEB)

    Gastegger, Michael; Kauffmann, Clemens; Marquetand, Philipp, E-mail: philipp.marquetand@univie.ac.at [Institute of Theoretical Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 17, Vienna (Austria); Behler, Jörg [Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, Universitätsstraße 150, Bochum (Germany)

    2016-05-21

    Many approaches, which have been developed to express the potential energy of large systems, exploit the locality of the atomic interactions. A prominent example is the fragmentation methods in which the quantum chemical calculations are carried out for overlapping small fragments of a given molecule that are then combined in a second step to yield the system’s total energy. Here we compare the accuracy of the systematic molecular fragmentation approach with the performance of high-dimensional neural network (HDNN) potentials introduced by Behler and Parrinello. HDNN potentials are similar in spirit to the fragmentation approach in that the total energy is constructed as a sum of environment-dependent atomic energies, which are derived indirectly from electronic structure calculations. As a benchmark set, we use all-trans alkanes containing up to eleven carbon atoms at the coupled cluster level of theory. These molecules have been chosen because they allow to extrapolate reliable reference energies for very long chains, enabling an assessment of the energies obtained by both methods for alkanes including up to 10 000 carbon atoms. We find that both methods predict high-quality energies with the HDNN potentials yielding smaller errors with respect to the coupled cluster reference.

  19. Maximally resolved anharmonic OH vibrational spectrum of the water/ZnO(101 \\xAF 0) interface from a high-dimensional neural network potential

    Science.gov (United States)

    Quaranta, Vanessa; Hellström, Matti; Behler, Jörg; Kullgren, Jolla; Mitev, Pavlin D.; Hermansson, Kersti

    2018-06-01

    Unraveling the atomistic details of solid/liquid interfaces, e.g., by means of vibrational spectroscopy, is of vital importance in numerous applications, from electrochemistry to heterogeneous catalysis. Water-oxide interfaces represent a formidable challenge because a large variety of molecular and dissociated water species are present at the surface. Here, we present a comprehensive theoretical analysis of the anharmonic OH stretching vibrations at the water/ZnO(101 ¯ 0) interface as a prototypical case. Molecular dynamics simulations employing a reactive high-dimensional neural network potential based on density functional theory calculations have been used to sample the interfacial structures. In the second step, one-dimensional potential energy curves have been generated for a large number of configurations to solve the nuclear Schrödinger equation. We find that (i) the ZnO surface gives rise to OH frequency shifts up to a distance of about 4 Å from the surface; (ii) the spectrum contains a number of overlapping signals arising from different chemical species, with the frequencies decreasing in the order ν(adsorbed hydroxide) > ν(non-adsorbed water) > ν(surface hydroxide) > ν(adsorbed water); (iii) stretching frequencies are strongly influenced by the hydrogen bond pattern of these interfacial species. Finally, we have been able to identify substantial correlations between the stretching frequencies and hydrogen bond lengths for all species.

  20. Computer-aided diagnosis for phase-contrast X-ray computed tomography: quantitative characterization of human patellar cartilage with high-dimensional geometric features.

    Science.gov (United States)

    Nagarajan, Mahesh B; Coan, Paola; Huber, Markus B; Diemoz, Paul C; Glaser, Christian; Wismüller, Axel

    2014-02-01

    Phase-contrast computed tomography (PCI-CT) has shown tremendous potential as an imaging modality for visualizing human cartilage with high spatial resolution. Previous studies have demonstrated the ability of PCI-CT to visualize (1) structural details of the human patellar cartilage matrix and (2) changes to chondrocyte organization induced by osteoarthritis. This study investigates the use of high-dimensional geometric features in characterizing such chondrocyte patterns in the presence or absence of osteoarthritic damage. Geometrical features derived from the scaling index method (SIM) and statistical features derived from gray-level co-occurrence matrices were extracted from 842 regions of interest (ROI) annotated on PCI-CT images of ex vivo human patellar cartilage specimens. These features were subsequently used in a machine learning task with support vector regression to classify ROIs as healthy or osteoarthritic; classification performance was evaluated using the area under the receiver-operating characteristic curve (AUC). SIM-derived geometrical features exhibited the best classification performance (AUC, 0.95 ± 0.06) and were most robust to changes in ROI size. These results suggest that such geometrical features can provide a detailed characterization of the chondrocyte organization in the cartilage matrix in an automated and non-subjective manner, while also enabling classification of cartilage as healthy or osteoarthritic with high accuracy. Such features could potentially serve as imaging markers for evaluating osteoarthritis progression and its response to different therapeutic intervention strategies.

  1. High-dimensional analysis of the aging immune system: verification of age-associated differences in immune signaling responses in healthy donors.

    Science.gov (United States)

    Longo, Diane M; Louie, Brent; Ptacek, Jason; Friedland, Greg; Evensen, Erik; Putta, Santosh; Atallah, Michelle; Spellmeyer, David; Wang, Ena; Pos, Zoltan; Marincola, Francesco M; Schaeffer, Andrea; Lukac, Suzanne; Railkar, Radha; Beals, Chan R; Cesano, Alessandra; Carayannopoulos, Leonidas N; Hawtin, Rachael E

    2014-06-21

    Single-cell network profiling (SCNP) is a multiparametric flow cytometry-based approach that simultaneously measures evoked signaling in multiple cell subsets. Previously, using the SCNP approach, age-associated immune signaling responses were identified in a cohort of 60 healthy donors. In the current study, a high-dimensional analysis of intracellular signaling was performed by measuring 24 signaling nodes in 7 distinct immune cell subsets within PBMCs in an independent cohort of 174 healthy donors [144 elderly (>65 yrs); 30 young (25-40 yrs)]. Associations between age and 9 immune signaling responses identified in the previously published 60 donor cohort were confirmed in the current study. Furthermore, within the current study cohort, 48 additional immune signaling responses differed significantly between young and elderly donors. These associations spanned all profiled modulators and immune cell subsets. These results demonstrate that SCNP, a systems-based approach, can capture the complexity of the cellular mechanisms underlying immunological aging. Further, the confirmation of age associations in an independent donor cohort supports the use of SCNP as a tool for identifying reproducible predictive biomarkers in areas such as vaccine response and response to cancer immunotherapies.

  2. History of nutrient inputs to the northeastern United States, 1930-2000

    Science.gov (United States)

    Hale, Rebecca L.; Hoover, Joseph H.; Wollheim, Wilfred M.; Vörösmarty, Charles J.

    2013-04-01

    Humans have dramatically altered nutrient cycles at local to global scales. We examined changes in anthropogenic nutrient inputs to the northeastern United States (NE) from 1930 to 2000. We created a comprehensive time series of anthropogenic N and P inputs to 437 counties in the NE at 5 year intervals. Inputs included atmospheric N deposition, biological N2 fixation, fertilizer, detergent P, livestock feed, and human food. Exports included exports of feed and food and volatilization of ammonia. N inputs to the NE increased throughout the study period, primarily due to increases in atmospheric deposition and fertilizer. P inputs increased until 1970 and then declined due to decreased fertilizer and detergent inputs. Livestock consistently consumed the majority of nutrient inputs over time and space. The area of crop agriculture declined during the study period but consumed more nutrients as fertilizer. We found that stoichiometry (N:P) of inputs and absolute amounts of N matched nutritional needs (livestock, humans, crops) when atmospheric components (N deposition, N2 fixation) were not included. Differences between N and P led to major changes in N:P stoichiometry over time, consistent with global trends. N:P decreased from 1930 to 1970 due to increased inputs of P, and increased from 1970 to 2000 due to increased N deposition and fertilizer and decreases in P fertilizer and detergent use. We found that nutrient use is a dynamic product of social, economic, political, and environmental interactions. Therefore, future nutrient management must take into account these factors to design successful and effective nutrient reduction measures.

  3. Lag space estimation in time series modelling

    DEFF Research Database (Denmark)

    Goutte, Cyril

    1997-01-01

    The purpose of this article is to investigate some techniques for finding the relevant lag-space, i.e. input information, for time series modelling. This is an important aspect of time series modelling, as it conditions the design of the model through the regressor vector a.k.a. the input layer...

  4. Multi input single output model predictive control of non-linear bio-polymerization process

    Energy Technology Data Exchange (ETDEWEB)

    Arumugasamy, Senthil Kumar; Ahmad, Z. [School of Chemical Engineering, Univerisiti Sains Malaysia, Engineering Campus, Seri Ampangan,14300 Nibong Tebal, Seberang Perai Selatan, Pulau Pinang (Malaysia)

    2015-05-15

    This paper focuses on Multi Input Single Output (MISO) Model Predictive Control of bio-polymerization process in which mechanistic model is developed and linked with the feedforward neural network model to obtain a hybrid model (Mechanistic-FANN) of lipase-catalyzed ring-opening polymerization of ε-caprolactone (ε-CL) for Poly (ε-caprolactone) production. In this research, state space model was used, in which the input to the model were the reactor temperatures and reactor impeller speeds and the output were the molecular weight of polymer (M{sub n}) and polymer polydispersity index. State space model for MISO created using System identification tool box of Matlab™. This state space model is used in MISO MPC. Model predictive control (MPC) has been applied to predict the molecular weight of the biopolymer and consequently control the molecular weight of biopolymer. The result shows that MPC is able to track reference trajectory and give optimum movement of manipulated variable.

  5. Modality of Input and Vocabulary Acquisition

    Directory of Open Access Journals (Sweden)

    Tetyana Sydorenko

    2010-06-01

    Full Text Available This study examines the effect of input modality (video, audio, and captions, i.e., on-screen text in the same language as audio on (a the learning of written and aural word forms, (b overall vocabulary gains, (c attention to input, and (d vocabulary learning strategies of beginning L2 learners. Twenty-six second-semester learners of Russian participated in this study. Group one (N = 8 saw video with audio and captions (VAC; group two (N = 9 saw video with audio (VA; group three (N = 9 saw video with captions (VC. All participants completed written and aural vocabulary tests and a final questionnaire.The results indicate that groups with captions (VAC and VC scored higher on written than on aural recognition of word forms, while the reverse applied to the VA group. The VAC group learned more word meanings than the VA group. Results from the questionnaire suggest that learners paid most attention to captions, followed by video and audio, and acquired most words by associating them with visual images. Pedagogical implications of this study are that captioned video tends to aid recognition of written word forms and the learning of word meaning, while non-captioned video tends to improve listening comprehension as it facilitates recognition of aural word forms.

  6. [Prosody, speech input and language acquisition].

    Science.gov (United States)

    Jungheim, M; Miller, S; Kühn, D; Ptok, M

    2014-04-01

    In order to acquire language, children require speech input. The prosody of the speech input plays an important role. In most cultures adults modify their code when communicating with children. Compared to normal speech this code differs especially with regard to prosody. For this review a selective literature search in PubMed and Scopus was performed. Prosodic characteristics are a key feature of spoken language. By analysing prosodic features, children gain knowledge about underlying grammatical structures. Child-directed speech (CDS) is modified in a way that meaningful sequences are highlighted acoustically so that important information can be extracted from the continuous speech flow more easily. CDS is said to enhance the representation of linguistic signs. Taking into consideration what has previously been described in the literature regarding the perception of suprasegmentals, CDS seems to be able to support language acquisition due to the correspondence of prosodic and syntactic units. However, no findings have been reported, stating that the linguistically reduced CDS could hinder first language acquisition.

  7. FLUTAN 2.0. Input specifications

    International Nuclear Information System (INIS)

    Willerding, G.; Baumann, W.

    1996-05-01

    FLUTAN is a highly vectorized computer code for 3D fluiddynamic and thermal-hydraulic analyses in Cartesian or cylinder coordinates. It is related to the family of COMMIX codes originally developed at Argonne National Laboratory, USA, and particularly to COMMIX-1A and COMMIX-1B, which were made available to FZK in the frame of cooperation contracts within the fast reactor safety field. FLUTAN 2.0 is an improved version of the FLUTAN code released in 1992. It offers some additional innovations, e.g. the QUICK-LECUSSO-FRAM techniques for reducing numerical diffusion in the k-ε turbulence model equations; a higher sophisticated wall model for specifying a mass flow outside the surface walls together with its flow path and its associated inlet and outlet flow temperatures; and a revised and upgraded pressure boundary condition to fully include the outlet cells in the solution process of the conservation equations. Last but not least, a so-called visualization option based on VISART standards has been provided. This report contains detailed input instructions, presents formulations of the various model options, and explains how to use the code by means of comprehensive sample input. (orig.) [de

  8. Radionuclides in the oceans inputs and inventories

    International Nuclear Information System (INIS)

    Guegueniat, P.; Germain, P.; Metivier, H.

    1996-01-01

    Ten years after Chernobyl, following the decision by France to end nuclear weapon testing in the Pacific ocean, after the end of the OECD-NEA Coordinated Research and Environmental Surveillance programme related to low-level waste dumping in the deep ocean, and one hundred years after the discovery of radioactivity, the IPSN wanted to compile and review the available information on artificial radioactivity levels in seas and oceans. International experts have been invited to present data on inputs and inventories of radionuclides in the marine environment, and to describe the evolution of radioactivity levels in water, sediments and living organisms. Different sources of radionuclides present in the aquatic environment are described: atmospheric fallout before and after Chernobyl, industrial wastes, dumped wastes and ships, nuclear ship accidents, river inputs, earth-sea atmospheric transfers and experimental sites for nuclear testing. Radioactivity levels due to these sources are dealt with at ocean (Atlantic, Pacific and Indian) and sea level (Channel, North Sea, Irish Sea, Mediterranean, Baltic, Black Sea and Arctic seas). These data collected in the present book give an up-to-date assessment of radionuclide distributions which will be very useful to address scientific and wider public concerns about radionuclides found in the aquatic environment. It gives many references useful to those who want to deepen their understanding of particular aspects of marine radioecology. (authors)

  9. Ground motion input in seismic evaluation studies

    International Nuclear Information System (INIS)

    Sewell, R.T.; Wu, S.C.

    1996-07-01

    This report documents research pertaining to conservatism and variability in seismic risk estimates. Specifically, it examines whether or not artificial motions produce unrealistic evaluation demands, i.e., demands significantly inconsistent with those expected from real earthquake motions. To study these issues, two types of artificial motions are considered: (a) motions with smooth response spectra, and (b) motions with realistic variations in spectral amplitude across vibration frequency. For both types of artificial motion, time histories are generated to match target spectral shapes. For comparison, empirical motions representative of those that might result from strong earthquakes in the Eastern U.S. are also considered. The study findings suggest that artificial motions resulting from typical simulation approaches (aimed at matching a given target spectrum) are generally adequate and appropriate in representing the peak-response demands that may be induced in linear structures and equipment responding to real earthquake motions. Also, given similar input Fourier energies at high-frequencies, levels of input Fourier energy at low frequencies observed for artificial motions are substantially similar to those levels noted in real earthquake motions. In addition, the study reveals specific problems resulting from the application of Western U.S. type motions for seismic evaluation of Eastern U.S. nuclear power plants

  10. FED, Geometry Input Generator for Program TRUMP

    International Nuclear Information System (INIS)

    Schauer, D.A.; Elrod, D.C.

    1996-01-01

    1 - Description of program or function: FED reduces the effort required to obtain the necessary geometric input for problems which are to be solved using the heat-transfer code, TRUMP (NESC 771). TRUMP calculates transient and steady-state temperature distributions in multidimensional systems. FED can properly zone any body of revolution in one, or three dimensions. 2 - Method of solution: The region of interest must first be divided into areas which may consist of a common material. The boundaries of these areas are the required FED input. Each area is subdivided into volume nodes, and the geometrical properties are calculated. Finally, FED connects the adjacent nodes to one another, using the proper surface area, interface distance, and, if specified, radiation form factor and interface conductance. 3 - Restrictions on the complexity of the problem: Rectangular bodies can only be approximated by using a very large radius of revolution compared to the total radial thickness and by considering only a small angular segment in the circumferential direction

  11. Phylogenetic mixtures and linear invariants for equal input models.

    Science.gov (United States)

    Casanellas, Marta; Steel, Mike

    2017-04-01

    The reconstruction of phylogenetic trees from molecular sequence data relies on modelling site substitutions by a Markov process, or a mixture of such processes. In general, allowing mixed processes can result in different tree topologies becoming indistinguishable from the data, even for infinitely long sequences. However, when the underlying Markov process supports linear phylogenetic invariants, then provided these are sufficiently informative, the identifiability of the tree topology can be restored. In this paper, we investigate a class of processes that support linear invariants once the stationary distribution is fixed, the 'equal input model'. This model generalizes the 'Felsenstein 1981' model (and thereby the Jukes-Cantor model) from four states to an arbitrary number of states (finite or infinite), and it can also be described by a 'random cluster' process. We describe the structure and dimension of the vector spaces of phylogenetic mixtures and of linear invariants for any fixed phylogenetic tree (and for all trees-the so called 'model invariants'), on any number n of leaves. We also provide a precise description of the space of mixtures and linear invariants for the special case of [Formula: see text] leaves. By combining techniques from discrete random processes and (multi-) linear algebra, our results build on a classic result that was first established by James Lake (Mol Biol Evol 4:167-191, 1987).

  12. PCC/SRC, PCC and SRC Calculation from Multivariate Input for Sensitivity Analysis

    International Nuclear Information System (INIS)

    Iman, R.L.; Shortencarier, M.J.; Johnson, J.D.

    1995-01-01

    1 - Description of program or function: PCC/SRC is designed for use in conjunction with sensitivity analyses of complex computer models. PCC/SRC calculates the partial correlation coefficients (PCC) and the standardized regression coefficients (SRC) from the multivariate input to, and output from, a computer model. 2 - Method of solution: PCC/SRC calculates the coefficients on either the original observations or on the ranks of the original observations. These coefficients provide alternative measures of the relative contribution (importance) of each of the various input variables to the observed variations in output. Relationships between the coefficients and differences in their interpretations are identified. If the computer model output has an associated time or spatial history, PCC/SRC will generate a graph of the coefficients over time or space for each input-variable, output- variable combination of interest, indicating the importance of each input value over time or space. 3 - Restrictions on the complexity of the problem - Maxima of: 100 observations, 100 different time steps or intervals between successive dependent variable readings, 50 independent variables (model input), 20 dependent variables (model output). 10 ordered triples specifying intervals between dependent variable readings

  13. Reconstruction of neuronal input through modeling single-neuron dynamics and computations

    International Nuclear Information System (INIS)

    Qin, Qing; Wang, Jiang; Yu, Haitao; Deng, Bin; Chan, Wai-lok

    2016-01-01

    Mathematical models provide a mathematical description of neuron activity, which can better understand and quantify neural computations and corresponding biophysical mechanisms evoked by stimulus. In this paper, based on the output spike train evoked by the acupuncture mechanical stimulus, we present two different levels of models to describe the input-output system to achieve the reconstruction of neuronal input. The reconstruction process is divided into two steps: First, considering the neuronal spiking event as a Gamma stochastic process. The scale parameter and the shape parameter of Gamma process are, respectively, defined as two spiking characteristics, which are estimated by a state-space method. Then, leaky integrate-and-fire (LIF) model is used to mimic the response system and the estimated spiking characteristics are transformed into two temporal input parameters of LIF model, through two conversion formulas. We test this reconstruction method by three different groups of simulation data. All three groups of estimates reconstruct input parameters with fairly high accuracy. We then use this reconstruction method to estimate the non-measurable acupuncture input parameters. Results show that under three different frequencies of acupuncture stimulus conditions, estimated input parameters have an obvious difference. The higher the frequency of the acupuncture stimulus is, the higher the accuracy of reconstruction is.

  14. Reconstruction of neuronal input through modeling single-neuron dynamics and computations

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Qing; Wang, Jiang; Yu, Haitao; Deng, Bin, E-mail: dengbin@tju.edu.cn; Chan, Wai-lok [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)

    2016-06-15

    Mathematical models provide a mathematical description of neuron activity, which can better understand and quantify neural computations and corresponding biophysical mechanisms evoked by stimulus. In this paper, based on the output spike train evoked by the acupuncture mechanical stimulus, we present two different levels of models to describe the input-output system to achieve the reconstruction of neuronal input. The reconstruction process is divided into two steps: First, considering the neuronal spiking event as a Gamma stochastic process. The scale parameter and the shape parameter of Gamma process are, respectively, defined as two spiking characteristics, which are estimated by a state-space method. Then, leaky integrate-and-fire (LIF) model is used to mimic the response system and the estimated spiking characteristics are transformed into two temporal input parameters of LIF model, through two conversion formulas. We test this reconstruction method by three different groups of simulation data. All three groups of estimates reconstruct input parameters with fairly high accuracy. We then use this reconstruction method to estimate the non-measurable acupuncture input parameters. Results show that under three different frequencies of acupuncture stimulus conditions, estimated input parameters have an obvious difference. The higher the frequency of the acupuncture stimulus is, the higher the accuracy of reconstruction is.

  15. Self-Structured Organizing Single-Input CMAC Control for Robot Manipulator

    Directory of Open Access Journals (Sweden)

    ThanhQuyen Ngo

    2011-09-01

    Full Text Available This paper represents a self-structured organizing single-input control system based on differentiable cerebellar model articulation controller (CMAC for an n-link robot manipulator to achieve the high-precision position tracking. In the proposed scheme, the single-input CMAC controller is solely used to control the plant, so the input space dimension of CMAC can be simplified and no conventional controller is needed. The structure of single-input CMAC will also be self-organized; that is, the layers of single-input CMAC will grow or prune systematically and their receptive functions can be automatically adjusted. The online tuning laws of single-input CMAC parameters are derived in gradient-descent learning method and the discrete-type Lyapunov function is applied to determine the learning rates of proposed control system so that the stability of the system can be guaranteed. The simulation results of robot manipulator are provided to verify the effectiveness of the proposed control methodology.

  16. Effects of modulation techniques on the input current interharmonics of Adjustable Speed Drives

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Zare, Firuz

    2018-01-01

    operation of the grid. This paper presents the effect of the symmetrical regularly sampled Space Vector Modulation (SVM) and Discontinuous Pulse Width Modulation-30olag (DPWM2) techniques, as the most popular modulation methods in the ASD applications, on the drive’s input current interharmonic magnitudes....... Further investigations are also devoted to the cases, where the Random Modulation (RM) technique is applied on the selected modulation strategies. The comparative results show that how different modulation techniques can influence the ASD’s input current interharmonics and consequently may...

  17. Do dyslexics have auditory input processing difficulties?

    DEFF Research Database (Denmark)

    Poulsen, Mads

    2011-01-01

    Word production difficulties are well documented in dyslexia, whereas the results are mixed for receptive phonological processing. This asymmetry raises the possibility that the core phonological deficit of dyslexia is restricted to output processing stages. The present study investigated whether....... The finding suggests that input processing difficulties are associated with the phonological deficit, but that these difficulties may be stronger above the level of phoneme perception.......Word production difficulties are well documented in dyslexia, whereas the results are mixed for receptive phonological processing. This asymmetry raises the possibility that the core phonological deficit of dyslexia is restricted to output processing stages. The present study investigated whether...... a group of dyslexics had word level receptive difficulties using an auditory lexical decision task with long words and nonsense words. The dyslexics were slower and less accurate than chronological age controls in an auditory lexical decision task, with disproportionate low performance on nonsense words...

  18. Auto Draw from Excel Input Files

    Science.gov (United States)

    Strauss, Karl F.; Goullioud, Renaud; Cox, Brian; Grimes, James M.

    2011-01-01

    The design process often involves the use of Excel files during project development. To facilitate communications of the information in the Excel files, drawings are often generated. During the design process, the Excel files are updated often to reflect new input. The problem is that the drawings often lag the updates, often leading to confusion of the current state of the design. The use of this program allows visualization of complex data in a format that is more easily understandable than pages of numbers. Because the graphical output can be updated automatically, the manual labor of diagram drawing can be eliminated. The more frequent update of system diagrams can reduce confusion and reduce errors and is likely to uncover symmetric problems earlier in the design cycle, thus reducing rework and redesign.

  19. Optimizing microwave photodetection: input-output theory

    Science.gov (United States)

    Schöndorf, M.; Govia, L. C. G.; Vavilov, M. G.; McDermott, R.; Wilhelm, F. K.

    2018-04-01

    High fidelity microwave photon counting is an important tool for various areas from background radiation analysis in astronomy to the implementation of circuit quantum electrodynamic architectures for the realization of a scalable quantum information processor. In this work we describe a microwave photon counter coupled to a semi-infinite transmission line. We employ input-output theory to examine a continuously driven transmission line as well as traveling photon wave packets. Using analytic and numerical methods, we calculate the conditions on the system parameters necessary to optimize measurement and achieve high detection efficiency. With this we can derive a general matching condition depending on the different system rates, under which the measurement process is optimal.

  20. Input and output constraints affecting irrigation development

    Science.gov (United States)

    Schramm, G.

    1981-05-01

    In many of the developing countries the expansion of irrigated agriculture is used as a major development tool for bringing about increases in agricultural output, rural economic growth and income distribution. Apart from constraints imposed by water availability, the major limitations considered to any acceleration of such programs are usually thought to be those of costs and financial resources. However, as is shown on the basis of empirical data drawn from Mexico, in reality the feasibility and effectiveness of such development programs is even more constrained by the lack of specialized physical and human factors on the input and market limitations on the output side. On the input side, the limited availability of complementary factors such as, for example, truly functioning credit systems for small-scale farmers or effective agricultural extension services impose long-term constraints on development. On the output side the limited availability, high risk, and relatively slow growth of markets for high-value crops sharply reduce the usually hoped-for and projected profitable crop mix that would warrant the frequently high costs of irrigation investments. Three conclusions are drawn: (1) Factors in limited supply have to be shadow-priced to reflect their high opportunity costs in alternative uses. (2) Re-allocation of financial resources from immediate construction of projects to longer-term increase in the supply of scarce, highly-trained manpower resources are necessary in order to optimize development over time. (3) Inclusion of high-value, high-income producing crops in the benefit-cost analysis of new projects is inappropriate if these crops could potentially be grown in already existing projects.

  1. Distribution Development for STORM Ingestion Input Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Fulton, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-07-01

    The Sandia-developed Transport of Radioactive Materials (STORM) code suite is used as part of the Radioisotope Power System Launch Safety (RPSLS) program to perform statistical modeling of the consequences due to release of radioactive material given a launch accident. As part of this modeling, STORM samples input parameters from probability distributions with some parameters treated as constants. This report described the work done to convert four of these constant inputs (Consumption Rate, Average Crop Yield, Cropland to Landuse Database Ratio, and Crop Uptake Factor) to sampled values. Consumption rate changed from a constant value of 557.68 kg / yr to a normal distribution with a mean of 102.96 kg / yr and a standard deviation of 2.65 kg / yr. Meanwhile, Average Crop Yield changed from a constant value of 3.783 kg edible / m 2 to a normal distribution with a mean of 3.23 kg edible / m 2 and a standard deviation of 0.442 kg edible / m 2 . The Cropland to Landuse Database ratio changed from a constant value of 0.0996 (9.96%) to a normal distribution with a mean value of 0.0312 (3.12%) and a standard deviation of 0.00292 (0.29%). Finally the crop uptake factor changed from a constant value of 6.37e-4 (Bq crop /kg)/(Bq soil /kg) to a lognormal distribution with a geometric mean value of 3.38e-4 (Bq crop /kg)/(Bq soil /kg) and a standard deviation value of 3.33 (Bq crop /kg)/(Bq soil /kg)

  2. Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example.

    Science.gov (United States)

    Le, Hoa V; Poole, Charles; Brookhart, M Alan; Schoenbach, Victor J; Beach, Kathleen J; Layton, J Bradley; Stürmer, Til

    2013-11-19

    The High-Dimensional Propensity Score (hd-PS) algorithm can select and adjust for baseline confounders of treatment-outcome associations in pharmacoepidemiologic studies that use healthcare claims data. How hd-PS performance is affected by aggregating medications or medical diagnoses has not been assessed. We evaluated the effects of aggregating medications or diagnoses on hd-PS performance in an empirical example using resampled cohorts with small sample size, rare outcome incidence, or low exposure prevalence. In a cohort study comparing the risk of upper gastrointestinal complications in celecoxib or traditional NSAIDs (diclofenac, ibuprofen) initiators with rheumatoid arthritis and osteoarthritis, we (1) aggregated medications and International Classification of Diseases-9 (ICD-9) diagnoses into hierarchies of the Anatomical Therapeutic Chemical classification (ATC) and the Clinical Classification Software (CCS), respectively, and (2) sampled the full cohort using techniques validated by simulations to create 9,600 samples to compare 16 aggregation scenarios across 50% and 20% samples with varying outcome incidence and exposure prevalence. We applied hd-PS to estimate relative risks (RR) using 5 dimensions, predefined confounders, ≤ 500 hd-PS covariates, and propensity score deciles. For each scenario, we calculated: (1) the geometric mean RR; (2) the difference between the scenario mean ln(RR) and the ln(RR) from published randomized controlled trials (RCT); and (3) the proportional difference in the degree of estimated confounding between that scenario and the base scenario (no aggregation). Compared with the base scenario, aggregations of medications into ATC level 4 alone or in combination with aggregation of diagnoses into CCS level 1 improved the hd-PS confounding adjustment in most scenarios, reducing residual confounding compared with the RCT findings by up to 19%. Aggregation of codes using hierarchical coding systems may improve the performance of

  3. High-dimensional nested analysis of variance to assess the effect of production season, quality grade and steam pasteurization on the phenolic composition of fermented rooibos herbal tea.

    Science.gov (United States)

    Stanimirova, I; Kazura, M; de Beer, D; Joubert, E; Schulze, A E; Beelders, T; de Villiers, A; Walczak, B

    2013-10-15

    A nested analysis of variance combined with simultaneous component analysis, ASCA, was proposed to model high-dimensional chromatographic data. The data were obtained from an experiment designed to investigate the effect of production season, quality grade and post-production processing (steam pasteurization) on the phenolic content of the infusion of the popular herbal tea, rooibos, at 'cup-of-tea' strength. Specifically, a four-way analysis of variance where the experimental design involves nesting in two of the three crossed factors was considered. For the purpose of the study, batches of fermented rooibos plant material were sampled from each of four quality grades during three production seasons (2009, 2010 and 2011) and a sub-sample of each batch was steam-pasteurized. The phenolic content of each rooibos infusion was characterized by high performance liquid chromatography (HPLC)-diode array detection (DAD). In contrast to previous studies, the complete HPLC-DAD signals were used in the chemometric analysis in order to take into account the entire phenolic profile. All factors had a significant effect on the phenolic content of a 'cup-of-tea' strength rooibos infusion. In particular, infusions prepared from the grade A (highest quality) samples contained a higher content of almost all phenolic compounds than the lower quality plant material. The variations of the content of isoorientin and orientin in the different quality grade infusions over production seasons are larger than the variations in the content of aspalathin and quercetin-3-O-robinobioside. Ferulic acid can be used as an indicator of the quality of rooibos tea as its content generally decreases with increasing tea quality. Steam pasteurization decreased the content of the majority of phenolic compounds in a 'cup-of-tea' strength rooibos infusion. © 2013 Elsevier B.V. All rights reserved.

  4. Analysis on relation between safety input and accidents

    Institute of Scientific and Technical Information of China (English)

    YAO Qing-guo; ZHANG Xue-mu; LI Chun-hui

    2007-01-01

    The number of safety input directly determines the level of safety, and there exists dialectical and unified relations between safety input and accidents. Based on the field investigation and reliable data, this paper deeply studied the dialectical relationship between safety input and accidents, and acquired the conclusions. The security situation of the coal enterprises was related to the security input rate, being effected little by the security input scale, and build the relationship model between safety input and accidents on this basis, that is the accident model.

  5. Modal Parameter Identification from Responses of General Unknown Random Inputs

    DEFF Research Database (Denmark)

    Ibrahim, S. R.; Asmussen, J. C.; Brincker, Rune

    1996-01-01

    Modal parameter identification from ambient responses due to a general unknown random inputs is investigated. Existing identification techniques which are based on assumptions of white noise and or stationary random inputs are utilized even though the inputs conditions are not satisfied....... This is accomplished via adding. In cascade. A force cascade conversion to the structures system under consideration. The input to the force conversion system is white noise and the output of which is the actual force(s) applied to the structure. The white noise input(s) and the structures responses are then used...

  6. Effect of input compression and input frequency response on music perception in cochlear implant users.

    Science.gov (United States)

    Halliwell, Emily R; Jones, Linor L; Fraser, Matthew; Lockley, Morag; Hill-Feltham, Penelope; McKay, Colette M

    2015-06-01

    A study was conducted to determine whether modifications to input compression and input frequency response characteristics can improve music-listening satisfaction in cochlear implant users. Experiment 1 compared three pre-processed versions of music and speech stimuli in a laboratory setting: original, compressed, and flattened frequency response. Music excerpts comprised three music genres (classical, country, and jazz), and a running speech excerpt was compared. Experiment 2 implemented a flattened input frequency response in the speech processor program. In a take-home trial, participants compared unaltered and flattened frequency responses. Ten and twelve adult Nucleus Freedom cochlear implant users participated in Experiments 1 and 2, respectively. Experiment 1 revealed a significant preference for music stimuli with a flattened frequency response compared to both original and compressed stimuli, whereas there was a significant preference for the original (rising) frequency response for speech stimuli. Experiment 2 revealed no significant mean preference for the flattened frequency response, with 9 of 11 subjects preferring the rising frequency response. Input compression did not alter music enjoyment. Comparison of the two experiments indicated that individual frequency response preferences may depend on the genre or familiarity, and particularly whether the music contained lyrics.

  7. Robust input design for nonlinear dynamic modeling of AUV.

    Science.gov (United States)

    Nouri, Nowrouz Mohammad; Valadi, Mehrdad

    2017-09-01

    Input design has a dominant role in developing the dynamic model of autonomous underwater vehicles (AUVs) through system identification. Optimal input design is the process of generating informative inputs that can be used to generate the good quality dynamic model of AUVs. In a problem with optimal input design, the desired input signal depends on the unknown system which is intended to be identified. In this paper, the input design approach which is robust to uncertainties in model parameters is used. The Bayesian robust design strategy is applied to design input signals for dynamic modeling of AUVs. The employed approach can design multiple inputs and apply constraints on an AUV system's inputs and outputs. Particle swarm optimization (PSO) is employed to solve the constraint robust optimization problem. The presented algorithm is used for designing the input signals for an AUV, and the estimate obtained by robust input design is compared with that of the optimal input design. According to the results, proposed input design can satisfy both robustness of constraints and optimality. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  8. IT Challenges for Space Medicine

    Science.gov (United States)

    Johnson-Throop, Kathy

    2010-01-01

    This viewgraph presentation reviews the various Information Technology challenges for aerospace medicine. The contents include: 1) Space Medicine Activities; 2) Private Medical Information; 3) Lifetime Surveillance of Astronaut Health; 4) Mission Medical Support; 5) Data Repositories for Research; 6) Data Input and Output; 7) Finding Data/Information; 8) Summary of Challenges; and 9) Solutions and questions.

  9. Discrete Input Signaling for MISO Visible Light Communication Channels

    KAUST Repository

    Arfaoui, Mohamed Amine; Rezki, Zouheir; Ghrayeb, Ali; Alouini, Mohamed-Slim

    2017-01-01

    In this paper, we study the achievable secrecy rate of visible light communication (VLC) links for discrete input distributions. We consider single user single eavesdropper multiple-input single-output (MISO) links. In addition, both beamforming

  10. Neighborhood spaces

    OpenAIRE

    D. C. Kent; Won Keun Min

    2002-01-01

    Neighborhood spaces, pretopological spaces, and closure spaces are topological space generalizations which can be characterized by means of their associated interior (or closure) operators. The category NBD of neighborhood spaces and continuous maps contains PRTOP as a bicoreflective subcategory and CLS as a bireflective subcategory, whereas TOP is bireflectively embedded in PRTOP and bicoreflectively embedded in CLS. Initial and final structures are described in these categories, and it is s...

  11. Characteristic features of determining the labor input and estimated cost of the development and manufacture of equipment

    Science.gov (United States)

    Kurmanaliyev, T. I.; Breslavets, A. V.

    1974-01-01

    The difficulties in obtaining exact calculation data for the labor input and estimated cost are noted. The method of calculating the labor cost of the design work using the provisional normative indexes with respect to individual forms of operations is proposed. Values of certain coefficients recommended for use in the practical calculations of the labor input for the development of new scientific equipment for space research are presented.

  12. Radioactive inputs to the North Sea and the Channel

    International Nuclear Information System (INIS)

    1984-01-01

    The subject is covered in sections: introduction (radioactivity; radioisotopes; discharges from nuclear establishments); data sources (statutory requirements); sources of liquid radioactive waste (figure showing location of principal sources of radioactive discharges; tables listing principal discharges by activity and by nature of radioisotope); Central Electricity Generating Board nuclear power stations; research and industrial establishments; Ministy of Defence establishments; other UK inputs of radioactive waste; total inputs to the North Sea and the Channel (direct inputs; river inputs; adjacent sea areas); conclusions. (U.K.)

  13. Calibrating the input accountancy tanks on THORP

    International Nuclear Information System (INIS)

    Whyte, C.G.; Hillier, A.P.; Temple, A.

    1995-01-01

    BNFL's Thermal Oxide Reprocessing Plant (THORP), at Sellafield in the UK, processes oxide fuels from customers around the world. The fuel moves through the plant from shearing and dissolution in the Head End and subsequently to solvent extraction in the Chemical Plant. Clarified dissolver liquor is accumulated in three large buffer storage tanks (each of approximately 75 m 3 capacity), in the Head End prior to feeding to the Chemical Plant. The amount of dissolver liquor being passed to these tanks is accurately measured in one of two Input Accountancy Tanks, which are each of 23 m 3 working capacity, and are equipped with high accuracy weight and level measurement systems. Several papers have been published which describe the principles applied to achieve the Safeguarding of THORP. This paper describes the setting to work of a key measurement point in the THORP process and details the complex trials that were begun during the early commissioning phases, to ensure that these accountancy systems would eventually be fully characterized

  14. Information Fusion of Conflicting Input Data

    Directory of Open Access Journals (Sweden)

    Uwe Mönks

    2016-10-01

    Full Text Available Sensors, and also actuators or external sources such as databases, serve as data sources in order to realise condition monitoring of industrial applications or the acquisition of characteristic parameters like production speed or reject rate. Modern facilities create such a large amount of complex data that a machine operator is unable to comprehend and process the information contained in the data. Thus, information fusion mechanisms gain increasing importance. Besides the management of large amounts of data, further challenges towards the fusion algorithms arise from epistemic uncertainties (incomplete knowledge in the input signals as well as conflicts between them. These aspects must be considered during information processing to obtain reliable results, which are in accordance with the real world. The analysis of the scientific state of the art shows that current solutions fulfil said requirements at most only partly. This article proposes the multilayered information fusion system MACRO (multilayer attribute-based conflict-reducing observation employing the μBalTLCS (fuzzified balanced two-layer conflict solving fusion algorithm to reduce the impact of conflicts on the fusion result. The performance of the contribution is shown by its evaluation in the scope of a machine condition monitoring application under laboratory conditions. Here, the MACRO system yields the best results compared to state-of-the-art fusion mechanisms. The utilised data is published and freely accessible.

  15. Information Fusion of Conflicting Input Data.

    Science.gov (United States)

    Mönks, Uwe; Dörksen, Helene; Lohweg, Volker; Hübner, Michael

    2016-10-29

    Sensors, and also actuators or external sources such as databases, serve as data sources in order to realise condition monitoring of industrial applications or the acquisition of characteristic parameters like production speed or reject rate. Modern facilities create such a large amount of complex data that a machine operator is unable to comprehend and process the information contained in the data. Thus, information fusion mechanisms gain increasing importance. Besides the management of large amounts of data, further challenges towards the fusion algorithms arise from epistemic uncertainties (incomplete knowledge) in the input signals as well as conflicts between them. These aspects must be considered during information processing to obtain reliable results, which are in accordance with the real world. The analysis of the scientific state of the art shows that current solutions fulfil said requirements at most only partly. This article proposes the multilayered information fusion system MACRO (multilayer attribute-based conflict-reducing observation) employing the μ BalTLCS (fuzzified balanced two-layer conflict solving) fusion algorithm to reduce the impact of conflicts on the fusion result. The performance of the contribution is shown by its evaluation in the scope of a machine condition monitoring application under laboratory conditions. Here, the MACRO system yields the best results compared to state-of-the-art fusion mechanisms. The utilised data is published and freely accessible.

  16. Vomeronasal inputs to the rodent ventral striatum.

    Science.gov (United States)

    Ubeda-Bañon, I; Novejarque, A; Mohedano-Moriano, A; Pro-Sistiaga, P; Insausti, R; Martinez-Garcia, F; Lanuza, E; Martinez-Marcos, A

    2008-03-18

    Vertebrates sense chemical signals through the olfactory and vomeronasal systems. In squamate reptiles, which possess the largest vomeronasal system of all vertebrates, the accessory olfactory bulb projects to the nucleus sphericus, which in turn projects to a portion of the ventral striatum known as olfactostriatum. Characteristically, the olfactostriatum is innervated by neuropeptide Y, tyrosine hydroxylase and serotonin immunoreactive fibers. In this study, the possibility that a structure similar to the reptilian olfactostriatum might be present in the mammalian brain has been investigated. Injections of dextran-amines have been aimed at the posteromedial cortical amygdaloid nucleus (the putative mammalian homologue of the reptilian nucleus sphericus) of rats and mice. The resulting anterograde labeling includes the olfactory tubercle, the islands of Calleja and sparse terminal fields in the shell of the nucleus accumbens and ventral pallidum. This projection has been confirmed by injections of retrograde tracers into the ventral striato-pallidum that render retrograde labeling in the posteromedial cortical amygdaloid nucleus. The analysis of the distribution of neuropeptide Y, tyrosine hydroxylase, serotonin and substance P in the ventral striato-pallidum of rats, and the anterograde tracing of the vomeronasal amygdaloid input in the same material confirm that, similar to reptiles, the ventral striatum of mammals includes a specialized vomeronasal structure (olfactory tubercle and islands of Calleja) displaying dense neuropeptide Y-, tyrosine hydroxylase- and serotonin-immunoreactive innervations. The possibility that parts of the accumbens shell and/or ventral pallidum could be included in the mammalian olfactostriatum cannot be discarded.

  17. Grammar in Context using Comprehended Input

    Directory of Open Access Journals (Sweden)

    Mariam Mohamed Nor

    2014-03-01

    Full Text Available There have been so many ongoing disputes on different approaches to teaching grammar. This study aims to evaluate the effectiveness of teaching grammar using Gass comprehended Input technique (GCI (1997 (implicit and to explore the undergraduates’ perception on the GCI technique. The respondents consisted of 30 undergraduates’ who are currently pursuing their Bachelor of English. Using the qualitative method, the research instrument was a set of 23- item interview and content analysis of the students’ written work. Results showed that the teaching of grammar using explicit instructions was more preferred than implicit instruction for complex components in grammatical rules. However, implicit instruction is equally effective regardless of the proficiency levels to enable pedagogy to be executed. It is also noted that there is lots of room for improvement, since the undergraduates have a weak grasp of the basic tense aspect of English grammar. Therefore, the Malaysian Ministry of Education should consider having grammar formally taught in isolation as what was practised previously.

  18. Remote sensing inputs to water demand modeling

    Science.gov (United States)

    Estes, J. E.; Jensen, J. R.; Tinney, L. R.; Rector, M.

    1975-01-01

    In an attempt to determine the ability of remote sensing techniques to economically generate data required by water demand models, the Geography Remote Sensing Unit, in conjunction with the Kern County Water Agency of California, developed an analysis model. As a result it was determined that agricultural cropland inventories utilizing both high altitude photography and LANDSAT imagery can be conducted cost effectively. In addition, by using average irrigation application rates in conjunction with cropland data, estimates of agricultural water demand can be generated. However, more accurate estimates are possible if crop type, acreage, and crop specific application rates are employed. An analysis of the effect of saline-alkali soils on water demand in the study area is also examined. Finally, reference is made to the detection and delineation of water tables that are perched near the surface by semi-permeable clay layers. Soil salinity prediction, automated crop identification on a by-field basis, and a potential input to the determination of zones of equal benefit taxation are briefly touched upon.

  19. Comparison of Linear Microinstability Calculations of Varying Input Realism

    International Nuclear Information System (INIS)

    Rewoldt, G.

    2003-01-01

    The effect of varying ''input realism'' or varying completeness of the input data for linear microinstability calculations, in particular on the critical value of the ion temperature gradient for the ion temperature gradient mode, is investigated using gyrokinetic and gyrofluid approaches. The calculations show that varying input realism can have a substantial quantitative effect on the results

  20. Inputs and spatial distribution patterns of Cr in Jiaozhou Bay

    Science.gov (United States)

    Yang, Dongfang; Miao, Zhenqing; Huang, Xinmin; Wei, Linzhen; Feng, Ming

    2018-03-01

    Cr pollution in marine bays has been one of the critical environmental issues, and understanding the input and spatial distribution patterns is essential to pollution control. In according to the source strengths of the major pollution sources, the input patterns of pollutants to marine bay include slight, moderate and heavy, and the spatial distribution are corresponding to three block models respectively. This paper analyzed input patterns and distributions of Cr in Jiaozhou Bay, eastern China based on investigation on Cr in surface waters during 1979-1983. Results showed that the input strengths of Cr in Jiaozhou Bay could be classified as moderate input and slight input, and the input strengths were 32.32-112.30 μg L-1 and 4.17-19.76 μg L-1, respectively. The input patterns of Cr included two patterns of moderate input and slight input, and the horizontal distributions could be defined by means of Block Model 2 and Block Model 3, respectively. In case of moderate input pattern via overland runoff, Cr contents were decreasing from the estuaries to the bay mouth, and the distribution pattern was parallel. In case of moderate input pattern via marine current, Cr contents were decreasing from the bay mouth to the bay, and the distribution pattern was parallel to circular. The Block Models were able to reveal the transferring process of various pollutants, and were helpful to understand the distributions of pollutants in marine bay.

  1. Distinctiveness and Bidirectional Effects in Input Enhancement for Vocabulary Learning

    Science.gov (United States)

    Barcroft, Joe

    2003-01-01

    This study examined input enhancement and second language (L2) vocabulary learning while exploring the role of "distinctiveness," the degree to which an item in the input diverges from the form in which other items in the input are presented, with regard to the nature and direction of the effects of enhancement. In this study,…

  2. Input Manipulation, Enhancement and Processing: Theoretical Views and Empirical Research

    Science.gov (United States)

    Benati, Alessandro

    2016-01-01

    Researchers in the field of instructed second language acquisition have been examining the issue of how learners interact with input by conducting research measuring particular kinds of instructional interventions (input-oriented and meaning-based). These interventions include such things as input flood, textual enhancement and processing…

  3. 7 CFR 3431.4 - Solicitation of stakeholder input.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Solicitation of stakeholder input. 3431.4 Section... Designation of Veterinarian Shortage Situations § 3431.4 Solicitation of stakeholder input. The Secretary will solicit stakeholder input on the process and procedures used to designate veterinarian shortage situations...

  4. Comparison of linear microinstability calculations of varying input realism

    International Nuclear Information System (INIS)

    Rewoldt, G.; Kinsey, J.E.

    2004-01-01

    The effect of varying 'input realism' or varying completeness of the input data for linear microinstability calculations, in particular on the critical value of the ion temperature gradient for the ion temperature gradient mode, is investigated using gyrokinetic and gyrofluid approaches. The calculations show that varying input realism can have a substantial quantitative effect on the results

  5. Inverse Tasks In The Tsunami Problem: Nonlinear Regression With Inaccurate Input Data

    Science.gov (United States)

    Lavrentiev, M.; Shchemel, A.; Simonov, K.

    problem can be formally propounded this way: A distribution of various combinations of observed values should be estimated. Totality of the combinations is represented by the set of variables. The results of observations determine excerption of outputs. In the scope of the propounded problem continuous (along with its derivations) homomorphic reflec- tion of the space of hidden parameters to the space of observed parameters should be found. It allows to reconstruct lack information of the inputs when the number of the 1 inputs is not less than the number of hidden parameters and to estimate the distribution if information for synonymous prediction of unknown inputs is not sufficient. The following approach to build approximation based on the excerption is suggested: the excerption is supplemented with the hidden parameters, which are distributed uni- formly in a multidimensional limited space. Then one should find correspondence of model and observed outputs. Therefore the correspondence will provide that the best approximation is the most accurate. In the odd iterations dependence between hid- den inputs and outputs is being optimized (like the conventional problem is solved). Correspondence between tasks is changing in the case when the error is reducing and distribution of inputs remains intact. Therefore, a special transform is applied to reduce error at every iteration. If the mea- sure of distribution is constant, then the condition of transformations is simplified. Such transforms are named "canonical" or "volume invariant transforms" and, there- fore, are well known. This approach is suggested for solving main inverse task of the tsunami problem. Basing on registered tsunami in seaside and shelf to estimate parameters of tsunami's hearth. 2

  6. Sacred Space.

    Science.gov (United States)

    Adelstein, Pamela

    2018-01-01

    A space can be sacred, providing those who inhabit a particular space with sense of transcendence-being connected to something greater than oneself. The sacredness may be inherent in the space, as for a religious institution or a serene place outdoors. Alternatively, a space may be made sacred by the people within it and events that occur there. As medical providers, we have the opportunity to create sacred space in our examination rooms and with our patient interactions. This sacred space can be healing to our patients and can bring us providers opportunities for increased connection, joy, and gratitude in our daily work.

  7. Sobolev spaces

    CERN Document Server

    Adams, Robert A

    2003-01-01

    Sobolev Spaces presents an introduction to the theory of Sobolev Spaces and other related spaces of function, also to the imbedding characteristics of these spaces. This theory is widely used in pure and Applied Mathematics and in the Physical Sciences.This second edition of Adam''s ''classic'' reference text contains many additions and much modernizing and refining of material. The basic premise of the book remains unchanged: Sobolev Spaces is intended to provide a solid foundation in these spaces for graduate students and researchers alike.* Self-contained and accessible for readers in other disciplines.* Written at elementary level making it accessible to graduate students.

  8. Input/output plugin architecture for MDSplus

    International Nuclear Information System (INIS)

    Stillerman, Joshua; Fredian, Thomas; Manduchi, Gabriele

    2014-01-01

    The first version of MDSplus was released in 1991 for VAX/VMS. Since that time the underlying file formats have remained constant. The software however has evolved, it was ported to unix, linux, Windows, and Macintosh. In 1997 a TCP based protocol, mdsip, was added to provide network access to MDSplus data. In 2011 a mechanism was added to allow protocol plugins to permit the use of other transport mechanisms such as ssh to access data users. This paper describes a similar design which permits the insertion of plugins to handle the reading and writing of MDSplus data at the data storage level. Tree paths become URIs which specify the protocol, host, and protocol specific information. The protocol is provided by a dynamically activated shared library that can provide any consistent subset of the data store access API, treeshr. The existing low level network protocol called mdsip, is activated by defining tree paths like “host::/directory”. Using the new plugin mechanism this is re-implemented as an instance of the general plugin that replaces the low level treeshr input/output routines. It is specified by using a path like “mdsip://host/directory”. This architecture will make it possible to adapt the MDSplus data organization and analysis tools to other underlying data storage. The first new application of this, after the existing network protocol is implemented, will be a plugin based on a key value store. Key value stores, can provide inexpensive scalable, redundant data storage. An example of this might be an Amazon G3 plugin which would let you specify a tree path such as “AG3://container” to access MDSplus data stored in the cloud

  9. Input/output plugin architecture for MDSplus

    Energy Technology Data Exchange (ETDEWEB)

    Stillerman, Joshua, E-mail: jas@psfc.mit.edu [Massachusetts Institute of Technology, 175 Albany Street, Cambridge, MA 02139 (United States); Fredian, Thomas, E-mail: twf@psfc.mit.edu [Massachusetts Institute of Technology, 175 Albany Street, Cambridge, MA 02139 (United States); Manduchi, Gabriele, E-mail: gabriele.manduchi@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy)

    2014-05-15

    The first version of MDSplus was released in 1991 for VAX/VMS. Since that time the underlying file formats have remained constant. The software however has evolved, it was ported to unix, linux, Windows, and Macintosh. In 1997 a TCP based protocol, mdsip, was added to provide network access to MDSplus data. In 2011 a mechanism was added to allow protocol plugins to permit the use of other transport mechanisms such as ssh to access data users. This paper describes a similar design which permits the insertion of plugins to handle the reading and writing of MDSplus data at the data storage level. Tree paths become URIs which specify the protocol, host, and protocol specific information. The protocol is provided by a dynamically activated shared library that can provide any consistent subset of the data store access API, treeshr. The existing low level network protocol called mdsip, is activated by defining tree paths like “host::/directory”. Using the new plugin mechanism this is re-implemented as an instance of the general plugin that replaces the low level treeshr input/output routines. It is specified by using a path like “mdsip://host/directory”. This architecture will make it possible to adapt the MDSplus data organization and analysis tools to other underlying data storage. The first new application of this, after the existing network protocol is implemented, will be a plugin based on a key value store. Key value stores, can provide inexpensive scalable, redundant data storage. An example of this might be an Amazon G3 plugin which would let you specify a tree path such as “AG3://container” to access MDSplus data stored in the cloud.

  10. On the Nature of the Input in Optimality Theory

    DEFF Research Database (Denmark)

    Heck, Fabian; Müller, Gereon; Vogel, Ralf

    2002-01-01

    The input has two main functions in optimality theory (Prince and Smolensky 1993). First, the input defines the candidate set, in other words it determines which output candidates compete for optimality, and which do not. Second, the input is referred to by faithfulness constraints that prohibit...... output candidates from deviating from specifications in the input. Whereas there is general agreement concerning the relevance of the input in phonology, the nature of the input in syntax is notoriously unclear. In this article, we show that the input should not be taken to define syntactic candidate...... and syntax is due to a basic, irreducible difference between these two components of grammar: Syntax is an information preserving system, phonology is not....

  11. High-frequency matrix converter with square wave input

    Science.gov (United States)

    Carr, Joseph Alexander; Balda, Juan Carlos

    2015-03-31

    A device for producing an alternating current output voltage from a high-frequency, square-wave input voltage comprising, high-frequency, square-wave input a matrix converter and a control system. The matrix converter comprises a plurality of electrical switches. The high-frequency input and the matrix converter are electrically connected to each other. The control system is connected to each switch of the matrix converter. The control system is electrically connected to the input of the matrix converter. The control system is configured to operate each electrical switch of the matrix converter converting a high-frequency, square-wave input voltage across the first input port of the matrix converter and the second input port of the matrix converter to an alternating current output voltage at the output of the matrix converter.

  12. A Novel Coupled State/Input/Parameter Identification Method for Linear Structural Systems

    Directory of Open Access Journals (Sweden)

    Zhimin Wan

    2018-01-01

    Full Text Available In many engineering applications, unknown states, inputs, and parameters exist in the structures. However, most methods require one or two of these variables to be known in order to identify the other(s. Recently, the authors have proposed a method called EGDF for coupled state/input/parameter identification for nonlinear system in state space. However, the EGDF method based solely on acceleration measurements is found to be unstable, which can cause the drift of the identified inputs and displacements. Although some regularization methods can be adopted for solving the problem, they are not suitable for joint input-state identification in real time. In this paper, a strategy of data fusion of displacement and acceleration measurements is used to avoid the low-frequency drift in the identified inputs and structural displacements for linear structural systems. Two numerical examples about a plane truss and a single-stage isolation system are conducted to verify the effectiveness of the proposed modified EGDF algorithm.

  13. Calibration of uncertain inputs to computer models using experimentally measured quantities and the BMARS emulator

    International Nuclear Information System (INIS)

    Stripling, H.F.; McClarren, R.G.; Kuranz, C.C.; Grosskopf, M.J.; Rutter, E.; Torralva, B.R.

    2011-01-01

    We present a method for calibrating the uncertain inputs to a computer model using available experimental data. The goal of the procedure is to produce posterior distributions of the uncertain inputs such that when samples from the posteriors are used as inputs to future model runs, the model is more likely to replicate (or predict) the experimental response. The calibration is performed by sampling the space of the uncertain inputs, using the computer model (or, more likely, an emulator for the computer model) to assign weights to the samples, and applying the weights to produce the posterior distributions and generate predictions of new experiments within confidence bounds. The method is similar to the Markov chain Monte Carlo (MCMC) calibration methods with independent sampling with the exception that we generate samples beforehand and replace the candidate acceptance routine with a weighting scheme. We apply our method to the calibration of a Hyades 2D model of laser energy deposition in beryllium. We employ a Bayesian Multivariate Adaptive Regression Splines (BMARS) emulator as a surrogate for Hyades 2D. We treat a range of uncertainties in our system, including uncertainties in the experimental inputs, experimental measurement error, and systematic experimental timing errors. The results of the calibration are posterior distributions that both agree with intuition and improve the accuracy and decrease the uncertainty in experimental predictions. (author)

  14. Mixed Interaction Spaces

    DEFF Research Database (Denmark)

    Lykke-Olesen, Andreas; Eriksson, E.; Hansen, T.R.

    In this paper, we describe a new interaction technique for mobile devices named Mixed Interaction Space that uses the camera of the mobile device to track the position, size and rotation of a fixed-point. In this demonstration we will present a system that uses a hand-drawn circle, colored object...... or a person’s face as a fixed-point to determine the location of the device. We use these features as a 4 dimensional input vector to a set of different applications....

  15. A Stochastic Collocation Method for Elliptic Partial Differential Equations with Random Input Data

    KAUST Repository

    Babuška, Ivo; Nobile, Fabio; Tempone, Raul

    2010-01-01

    This work proposes and analyzes a stochastic collocation method for solving elliptic partial differential equations with random coefficients and forcing terms. These input data are assumed to depend on a finite number of random variables. The method consists of a Galerkin approximation in space and a collocation in the zeros of suitable tensor product orthogonal polynomials (Gauss points) in the probability space, and naturally leads to the solution of uncoupled deterministic problems as in the Monte Carlo approach. It treats easily a wide range of situations, such as input data that depend nonlinearly on the random variables, diffusivity coefficients with unbounded second moments, and random variables that are correlated or even unbounded. We provide a rigorous convergence analysis and demonstrate exponential convergence of the “probability error” with respect to the number of Gauss points in each direction of the probability space, under some regularity assumptions on the random input data. Numerical examples show the effectiveness of the method. Finally, we include a section with developments posterior to the original publication of this work. There we review sparse grid stochastic collocation methods, which are effective collocation strategies for problems that depend on a moderately large number of random variables.

  16. Effect of heat input on the microstructure and mechanical properties of gas tungsten arc welded AISI 304 stainless steel joints

    International Nuclear Information System (INIS)

    Kumar, Subodh; Shahi, A.S.

    2011-01-01

    Highlights: → Welding procedure is established for welding 6 mm thick AISI 304 using GTAW process. → Mechanical properties of the weld joints are influenced strongly by the heat input. → Highest tensile strength of 657.32 MPa is achieved by joints using low heat input. → Welding parameters affect heat input and hence microstructure of weld joints. → Extent of grain coarsening in the HAZ increases with increase in the heat input. -- Abstract: Influence of heat input on the microstructure and mechanical properties of gas tungsten arc welded 304 stainless steel (SS) joints was studied. Three heat input combinations designated as low heat (2.563 kJ/mm), medium heat (2.784 kJ/mm) and high heat (3.017 kJ/mm) were selected from the operating window of the gas tungsten arc welding process (GTAW) and weld joints made using these combinations were subjected to microstructural evaluations and tensile testing so as to analyze the effect of thermal arc energy on the microstructure and mechanical properties of these joints. The results of this investigation indicate that the joints made using low heat input exhibited higher ultimate tensile strength (UTS) than those welded with medium and high heat input. Significant grain coarsening was observed in the heat affected zone (HAZ) of all the joints and it was found that the extent of grain coarsening in the heat affected zone increased with increase in the heat input. For the joints investigated in this study it was also found that average dendrite length and inter-dendritic spacing in the weld zone increases with increase in the heat input which is the main reason for the observable changes in the tensile properties of the weld joints welded with different arc energy inputs.

  17. Longitudinal Phase Space Tomography with Space Charge

    CERN Document Server

    Hancock, S; Lindroos, M

    2000-01-01

    Tomography is now a very broad topic with a wealth of algorithms for the reconstruction of both qualitative and quantitative images. In an extension in the domain of particle accelerators, one of the simplest algorithms has been modified to take into account the non-linearity of large-amplitude synchrotron motion. This permits the accurate reconstruction of longitudinal phase space density from one-dimensional bunch profile data. The method is a hybrid one which incorporates particle tracking. Hitherto, a very simple tracking algorithm has been employed because only a brief span of measured profile data is required to build a snapshot of phase space. This is one of the strengths of the method, as tracking for relatively few turns relaxes the precision to which input machine parameters need to be known. The recent addition of longitudinal space charge considerations as an optional refinement of the code is described. Simplicity suggested an approach based on the derivative of bunch shape with the properties of...

  18. Response sensitivity of barrel neuron subpopulations to simulated thalamic input.

    Science.gov (United States)

    Pesavento, Michael J; Rittenhouse, Cynthia D; Pinto, David J

    2010-06-01

    Our goal is to examine the relationship between neuron- and network-level processing in the context of a well-studied cortical function, the processing of thalamic input by whisker-barrel circuits in rodent neocortex. Here we focus on neuron-level processing and investigate the responses of excitatory and inhibitory barrel neurons to simulated thalamic inputs applied using the dynamic clamp method in brain slices. Simulated inputs are modeled after real thalamic inputs recorded in vivo in response to brief whisker deflections. Our results suggest that inhibitory neurons require more input to reach firing threshold, but then fire earlier, with less variability, and respond to a broader range of inputs than do excitatory neurons. Differences in the responses of barrel neuron subtypes depend on their intrinsic membrane properties. Neurons with a low input resistance require more input to reach threshold but then fire earlier than neurons with a higher input resistance, regardless of the neuron's classification. Our results also suggest that the response properties of excitatory versus inhibitory barrel neurons are consistent with the response sensitivities of the ensemble barrel network. The short response latency of inhibitory neurons may serve to suppress ensemble barrel responses to asynchronous thalamic input. Correspondingly, whereas neurons acting as part of the barrel circuit in vivo are highly selective for temporally correlated thalamic input, excitatory barrel neurons acting alone in vitro are less so. These data suggest that network-level processing of thalamic input in barrel cortex depends on neuron-level processing of the same input by excitatory and inhibitory barrel neurons.

  19. Design spaces

    DEFF Research Database (Denmark)

    2005-01-01

    Digital technologies and media are becoming increasingly embodied and entangled in the spaces and places at work and at home. However, our material environment is more than a geometric abstractions of space: it contains familiar places, social arenas for human action. For designers, the integration...... of digital technology with space poses new challenges that call for new approaches. Creative alternatives to traditional systems methodologies are called for when designers use digital media to create new possibilities for action in space. Design Spaces explores how design and media art can provide creative...... alternatives for integrating digital technology with space. Connecting practical design work with conceptual development and theorizing, art with technology, and usesr-centered methods with social sciences, Design Spaces provides a useful research paradigm for designing ubiquitous computing. This book...

  20. Space Commercialization

    Science.gov (United States)

    Martin, Gary L.

    2011-01-01

    A robust and competitive commercial space sector is vital to continued progress in space. The United States is committed to encouraging and facilitating the growth of a U.S. commercial space sector that supports U.S. needs, is globally competitive, and advances U.S. leadership in the generation of new markets and innovation-driven entrepreneurship. Energize competitive domestic industries to participate in global markets and advance the development of: satellite manufacturing; satellite-based services; space launch; terrestrial applications; and increased entrepreneurship. Purchase and use commercial space capabilities and services to the maximum practical extent Actively explore the use of inventive, nontraditional arrangements for acquiring commercial space goods and services to meet United States Government requirements, including measures such as public-private partnerships, . Refrain from conducting United States Government space activities that preclude, discourage, or compete with U.S. commercial space activities. Pursue potential opportunities for transferring routine, operational space functions to the commercial space sector where beneficial and cost-effective.

  1. Automated input data management in manufacturing process simulation

    OpenAIRE

    Ettefaghian, Alireza

    2015-01-01

    Input Data Management (IDM) is a time consuming and costly process for Discrete Event Simulation (DES) projects. Input Data Management is considered as the basis of real-time process simulation (Bergmann, Stelzer and Strassburger, 2011). According to Bengtsson et al. (2009), data input phase constitutes on the average about 31% of the time of an entire simulation project. Moreover, the lack of interoperability between manufacturing applications and simulation software leads to a high cost to ...

  2. The Economic Impact of Tourism. An Input-Output Analysis

    OpenAIRE

    Camelia SURUGIU

    2009-01-01

    The paper presents an Input-Output Analysis for Romania, an important source of information for the investigation of the inter-relations existing among different industries. The Input-Output Analysis is used to determine the role and importance of different economic value added, incomes and employment and it analyses the existing connection in an economy. This paper is focused on tourism and the input-output analysis is finished for the Hotels and Restaurants Sector.

  3. Socio-Economic Impacts of Space Weather and User Needs for Space Weather Information

    Science.gov (United States)

    Worman, S. L.; Taylor, S. M.; Onsager, T. G.; Adkins, J. E.; Baker, D. N.; Forbes, K. F.

    2017-12-01

    The 2015 National Space Weather Strategy and Space Weather Action Plan (SWAP) details the activities, outcomes, and timelines to build a "Space Weather Ready Nation." NOAA's Space Weather Prediction Center and Abt Associates are working together on two SWAP initiatives: (1) identifying, describing, and quantifying the socio-economic impacts of moderate and severe space weather; and (2) outreach to engineers and operators to better understand user requirements for space weather products and services. Both studies cover four technological sectors (electric power, commercial aviation, satellites, and GNSS users) and rely heavily on industry input. Findings from both studies are essential for decreasing vulnerabilities and enhancing preparedness.

  4. Learning Spaces

    CERN Document Server

    Falmagne, Jean-Claude

    2011-01-01

    Learning spaces offer a rigorous mathematical foundation for practical systems of educational technology. Learning spaces generalize partially ordered sets and are special cases of knowledge spaces. The various structures are investigated from the standpoints of combinatorial properties and stochastic processes. Leaning spaces have become the essential structures to be used in assessing students' competence of various topics. A practical example is offered by ALEKS, a Web-based, artificially intelligent assessment and learning system in mathematics and other scholarly fields. At the heart of A

  5. Modelling of air-conditioned and heated spaces

    Energy Technology Data Exchange (ETDEWEB)

    Moehl, U

    1987-01-01

    A space represents a complex system involving numerous components, manipulated variables and disturbances which need to be described if dynamic behaviour of space air is to be determined. A justifiable amount of simulation input is determined by the application of adjusted modelling of the individual components. The determination of natural air exchange in heated spaces and of space-air flow in air-conditioned space are a primary source of uncertainties. (orig.).

  6. Estimation of the synaptic input firing rates and characterization of the stimulation effects in an auditory neuron

    Czech Academy of Sciences Publication Activity Database

    Kobayashi, R.; He, J.; Lánský, Petr

    2015-01-01

    Roč. 9, May 18 (2015), s. 59 ISSN 1662-5188 R&D Projects: GA ČR(CZ) GA15-08066S Institutional support: RVO:67985823 Keywords : synaptic inputs * statistical inference * state-space models * intracellular recordings * auditory cortex Subject RIV: BD - Theory of Information Impact factor: 2.653, year: 2015

  7. Comfort constraints. Input for simulation of residents' behavior; Comforthinder. Input bij simulatie van bewonersgedrag

    Energy Technology Data Exchange (ETDEWEB)

    Phaff, H. [TNO Bouw en Ondergrond, Delft (Netherlands)

    2010-04-15

    Buildings in reality, use more energy than predicted. Among many causes, occupant behaviour plays an important role. Better simulation of occupant behaviour, with respect to thermal comfort and energy use of buildings, opens the possibility to design better, comfortable buildings that have lower energy consumption in reality. Thermal discomfort, a dynamical version of Fanger's PPD, is proposed to be used as input to simulate occupant behaviour via a 'flexible task list' and two Markov processes. [Dutch] Simulatie van bewonersgedrag m.b.t. energiegebruik in gebouwen biedt de mogelijkheid om gebouwen en bijbehorende energie installaties zo te ontwerpen dat ze prettiger zijn om in te wonen en te werken. Thermisch discomfort, een dynamische versie van PPD (percentage of dissatisfied persons) wordt hier voorgesteld om via een Markov-proces en een takenlijst bewonersgedrag mee te simuleren.

  8. Input Harmonic Analysis on the Slim DC-Link Drive Using Harmonic State Space Model

    DEFF Research Database (Denmark)

    Yang, Feng; Kwon, Jun Bum; Wang, Xiongfei

    2017-01-01

    The harmonic performance of the slim dc-link adjustable speed drives has shown good performance in some studies but poor in some others. The contradiction indicates that a feasible theoretical analysis is still lacking to characterize the harmonic distortion for the slim dc-link drive. Considerin...... results of the slim dc-link drive, loaded up to 2.0 kW, are presented to validate the theoretical analysis....... variation according to the switching instant, the harmonics at the steady-state condition, as well as the coupling between the multiple harmonic impedances. By using this model, the impaction on the harmonics performance by the film capacitor and the grid inductance is derived. Simulation and experimental...

  9. BBN Model with Quantitative Inputs for Risk Analysis of Uncontrolled Fire in Machinery Space

    OpenAIRE

    Azizpour, Hooshyar

    2016-01-01

    The past decades has witnessed a significant increase in the number and volume of international trade through the sea. Thousands of ships are sailing in the coastal and international waters all over the world. Accident in the sea transport not only results loss of property for the owners of vessels and traders of cargo, but also threatens the environment and the humans who are directly or indirectly associated with the marine industry. One of the most dangerous accidents in ships is fire and...

  10. Input Space Regularization Stabilizes Pre-images for Kernel PCA De-noising

    DEFF Research Database (Denmark)

    Abrahamsen, Trine Julie; Hansen, Lars Kai

    2009-01-01

    Solution of the pre-image problem is key to efficient nonlinear de-noising using kernel Principal Component Analysis. Pre-image estimation is inherently ill-posed for typical kernels used in applications and consequently the most widely used estimation schemes lack stability. For de...

  11. Investigations of the sensitivity of a coronal mass ejection model (ENLIL) to solar input parameters

    DEFF Research Database (Denmark)

    Falkenberg, Thea Vilstrup; Vršnak, B.; Taktakishvili, A.

    2010-01-01

    Understanding space weather is not only important for satellite operations and human exploration of the solar system but also to phenomena here on Earth that may potentially disturb and disrupt electrical signals. Some of the most violent space weather effects are caused by coronal mass ejections...... (CMEs), but in order to predict the caused effects, we need to be able to model their propagation from their origin in the solar corona to the point of interest, e.g., Earth. Many such models exist, but to understand the models in detail we must understand the primary input parameters. Here we...... investigate the parameter space of the ENLILv2.5b model using the CME event of 25 July 2004. ENLIL is a time‐dependent 3‐D MHD model that can simulate the propagation of cone‐shaped interplanetary coronal mass ejections (ICMEs) through the solar system. Excepting the cone parameters (radius, position...

  12. High Resolution Modeling of the Thermospheric Response to Energy Inputs During the RENU-2 Rocket Flight

    Science.gov (United States)

    Walterscheid, R. L.; Brinkman, D. G.; Clemmons, J. H.; Hecht, J. H.; Lessard, M.; Fritz, B.; Hysell, D. L.; Clausen, L. B. N.; Moen, J.; Oksavik, K.; Yeoman, T. K.

    2017-12-01

    The Earth's magnetospheric cusp provides direct access of energetic particles to the thermosphere. These particles produce ionization and kinetic (particle) heating of the atmosphere. The increased ionization coupled with enhanced electric fields in the cusp produces increased Joule heating and ion drag forcing. These energy inputs cause large wind and temperature changes in the cusp region. The Rocket Experiment for Neutral Upwelling -2 (RENU-2) launched from Andoya, Norway at 0745UT on 13 December 2015 into the ionosphere-thermosphere beneath the magnetic cusp. It made measurements of the energy inputs (e.g., precipitating particles, electric fields) and the thermospheric response to these energy inputs (e.g., neutral density and temperature, neutral winds). Complementary ground based measurements were made. In this study, we use a high resolution two-dimensional time-dependent non hydrostatic nonlinear dynamical model driven by rocket and ground based measurements of the energy inputs to simulate the thermospheric response during the RENU-2 flight. Model simulations will be compared to the corresponding measurements of the thermosphere to see what they reveal about thermospheric structure and the nature of magnetosphere-ionosphere-thermosphere coupling in the cusp. Acknowledgements: This material is based upon work supported by the National Aeronautics and Space Administration under Grants: NNX16AH46G and NNX13AJ93G. This research was also supported by The Aerospace Corporation's Technical Investment program

  13. 40 CFR 1065.210 - Work input and output sensors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Work input and output sensors. 1065... Ambient Conditions § 1065.210 Work input and output sensors. (a) Application. Use instruments as specified... sensors, transducers, and meters that meet the specifications in Table 1 of § 1065.205. Note that your...

  14. Input reduction for long-term morphodynamic simulations

    NARCIS (Netherlands)

    Walstra, D.J.R.; Ruessink, G.; Hoekstra, R.; Tonnon, P.K.

    2013-01-01

    Input reduction is imperative to long-term (> years) morphodynamic simulations to avoid excessive computation times. Here, we discuss the input-reduction framework for wave-dominated coastal settings introduced by Walstra et al. (2013). The framework comprised 4 steps, viz. (1) the selection of the

  15. Identifying Inputs to Leadership Development within an Interdisciplinary Leadership Minor

    Science.gov (United States)

    McKim, Aaron J.; Sorensen, Tyson J.; Velez, Jonathan J.

    2015-01-01

    Researchers conducted a qualitative analysis of students' experiences while enrolled in an interdisciplinary leadership minor with the intent to determine programmatic inputs that spur leadership development. Based on students' reflections, three domains of programmatic inputs for leadership development within the minor were identified. These…

  16. Off-line learning from clustered input examples

    NARCIS (Netherlands)

    Marangi, Carmela; Solla, Sara A.; Biehl, Michael; Riegler, Peter; Marinaro, Maria; Tagliaferri, Roberto

    1996-01-01

    We analyze the generalization ability of a simple perceptron acting on a structured input distribution for the simple case of two clusters of input data and a linearly separable rule. The generalization ability computed for three learning scenarios: maximal stability, Gibbs, and optimal learning, is

  17. Phonology: An Emergent Consequence of Memory Constraints and Sensory Input.

    Science.gov (United States)

    Lacerda, Francisco

    2003-01-01

    Presents a theoretical model that attempts to account for the early stages of language acquisition in terms of interaction between biological constraints and input characteristics. Notes that the model uses the implications of stochastic representations of the sensory input in a volatile and limited memory. Argues that phonological structure is a…

  18. History of the special committee on INIS input preparation

    International Nuclear Information System (INIS)

    Itabashi, Keizo

    2011-06-01

    The special committee on INIS input techniques was held 8 times from December 1970 to March 1973. The special committee on INIS input preparation was held 39 times from February 1974 to December 2004. The history of these two committees is described. (author)

  19. Modeling recognition memory using the similarity structure of natural input

    NARCIS (Netherlands)

    Lacroix, J.P.W.; Murre, J.M.J.; Postma, E.O.; van den Herik, H.J.

    2006-01-01

    The natural input memory (NIM) model is a new model for recognition memory that operates on natural visual input. A biologically informed perceptual preprocessing method takes local samples (eye fixations) from a natural image and translates these into a feature-vector representation. During

  20. Modeling Recognition Memory Using the Similarity Structure of Natural Input

    Science.gov (United States)

    Lacroix, Joyca P. W.; Murre, Jaap M. J.; Postma, Eric O.; van den Herik, H. Jaap

    2006-01-01

    The natural input memory (NAM) model is a new model for recognition memory that operates on natural visual input. A biologically informed perceptual preprocessing method takes local samples (eye fixations) from a natural image and translates these into a feature-vector representation. During recognition, the model compares incoming preprocessed…