ADC Catalog Services: an Update

Science.gov (United States)

Gass, J. E.; Roman, N. G.; Schneider, G. L.; Blackwell, J. H.; Kuin, N. P. M.; Larkin, M. C.; Lyu, C.-C. J.; Cheung, C. Y.

1996-12-01

The Astronomical Data Center (ADC) at the NASA Goddard Space Flight Center is a major archive and distribution center for computer-readable versions of astronomical catalogs and journal data tables. The ADC's archives contain more than 1600 catalogs and tables of astrometry, photometry, spectroscopy, radio, high energy, and other miscellaneous data for stellar and non-stellar objects. These data files are documented in a standardized manner, developed in cooperation with the Centre de Donnees astronomiques de Strasbourg (CDS). The ADC's data collection is available via anonymous FTP from node adc.gsfc.nasa.gov in the /pub/adc/archives directory. The holdings can also be accessed from the ADC's WWW site, http://adc.gsfc.nasa.gov/. This site permits users to search the text of the documentation files to locate catalogs and tables of interest or to browse the archives. Hypertext author and keyword indices, and other browsing tools have recently been developed as additional aids to navigating the ADC's large collection of data sets. The ADC is currently developing services to allow researchers to easily locate data fields of interest within files in its archives. The ADC has also prepared three volumes of CD-ROMs that contain several hundred of the largest and most requested catalogs in both ASCII and FITS table formats.

Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc.

Science.gov (United States)

Cao, Kun; Li, Nan; Wang, Hongcui; Cao, Xin; He, Jiaojiao; Zhang, Bing; He, Qing-Yu; Zhang, Gong; Sun, Xuesong

2018-04-20

Zinc is an essential metal in bacteria. One important bacterial zinc transporter is AdcA, and most bacteria possess AdcA homologs that are single-domain small proteins due to better efficiency of protein biogenesis. However, a double-domain AdcA with two zinc-binding sites is significantly overrepresented in Streptococcus species, many of which are major human pathogens. Using molecular simulation and experimental validations of AdcA from Streptococcus pyogenes , we found here that the two AdcA domains sequentially stabilize the structure upon zinc binding, indicating an organization required for both increased zinc affinity and transfer speed. This structural organization appears to endow Streptococcus species with distinct advantages in zinc-depleted environments, which would not be achieved by each single AdcA domain alone. This enhanced zinc transport mechanism sheds light on the significance of the evolution of the AdcA domain fusion, provides new insights into double-domain transporter proteins with two binding sites for the same ion, and indicates a potential target of antimicrobial drugs against pathogenic Streptococcus species. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

High precision 16K, 16 channel peak sensing CAMAC ADC

International Nuclear Information System (INIS)

Jain, Mamta; Subramaniam, E.T

2013-01-01

A high density, peak sensing, analog to digital converter (ADC) double width module with CAMAC back plane has been developed for nuclear physics experiments with a large number of detectors. This module has sixteen independent channels in plug-in daughter card mother board mode

Connect high speed analog-digital converter with EPICS based on LabVIEW

International Nuclear Information System (INIS)

Wang Wei; Chi Yunlong

2008-01-01

This paper introduce a method to connect high speed analog-digital converter (ADC212/100) with EPICS on Windows platform using LabVIEW. We use labVIEW to communicate with the converter, then use interface sub-VIs between LabVIEW and EPICS to access the EPICS IOC by Channel Access (CA). For the easy use graph programming language of LabVIEW, this method could shorten the develop period and reduce manpower cost. (authors)

A single-channel 10-bit 160 MS/s SAR ADC in 65 nm CMOS

International Nuclear Information System (INIS)

Lu Yuxiao; Sun Lu; Li Zhe; Zhou Jianjun

2014-01-01

This paper demonstrates a single-channel 10-bit 160 MS/s successive-approximation-register (SAR) analog-to-digital converter (ADC) in 65 nm CMOS process with a 1.2 V supply voltage. To achieve high speed, a new window-opening logic based on the asynchronous SAR algorithm is proposed to minimize the logic delay, and a partial set-and-down DAC with binary redundancy bits is presented to reduce the dynamic comparator offset and accelerate the DAC settling. Besides, a new bootstrapped switch with a pre-charge phase is adopted in the track and hold circuits to increase speed and reduce area. The presented ADC achieves 52.9 dB signal-to-noise distortion ratio and 65 dB spurious-free dynamic range measured with a 30 MHz input signal at 160 MHz clock. The power consumption is 9.5 mW and a core die area of 250 × 200 μm 2 is occupied. (semiconductor integrated circuits)

A 16 bit camac ADC with memory

International Nuclear Information System (INIS)

Wikne, J.C.

1986-01-01

A 16 bit camac-programmable analog-to-digital converter (ADC) with incorporated memory and sampling clock is described. This single-width camac module is especially suited for autonomous, multi-sample data acquisition with high precision. The ADC itself is a hybrid, the ADC76 from Burr-Brown, featuring a programmable input range and direct parallel output in two's complement form. The input programming is done by means of dual-in-line switches, giving input spans from 1.25 V to 20 V, unipolar or bipolar. The outline of the programming of the ADC input and the calibration of the unit is given

An 11-bit 200 MS/s subrange SAR ADC with low-cost integrated reference buffer

Science.gov (United States)

He, Xiuju; Gu, Xian; Li, Weitao; Jiang, Hanjun; Li, Fule; Wang, Zhihua

2017-10-01

This paper presents an 11-bit 200 MS/s subrange SAR ADC with an integrated reference buffer in 65 nm CMOS. The proposed ADC employs a 3.5-bit flash ADC for coarse conversion, and a compact timing scheme at the flash/SAR boundary to speed up the conversion. The flash decision is used to control charge compensating for the reference voltage to reduce its input-dependent fluctuation. Measurement results show that the fabricated ADC has achieved significant improvement by applying the reference charge compensation. In addition, the ADC achieves a maximum signal-to-noise-and-distortion ratio of 59.3 dB at 200 MS/s. It consumes 3.91 mW from a 1.2 V supply, including the reference buffer. Project supported by the Zhongxing Telecommunication Equipment Corporation and Beijing Microelectronics Technology Institute.

FPGA Flash Memory High Speed Data Acquisition

Science.gov (United States)

Gonzalez, April

2013-01-01

The purpose of this research is to design and implement a VHDL ONFI Controller module for a Modular Instrumentation System. The goal of the Modular Instrumentation System will be to have a low power device that will store data and send the data at a low speed to a processor. The benefit of such a system will give an advantage over other purchased binary IP due to the capability of allowing NASA to re-use and modify the memory controller module. To accomplish the performance criteria of a low power system, an in house auxiliary board (Flash/ADC board), FPGA development kit, debug board, and modular instrumentation board will be jointly used for the data acquisition. The Flash/ADC board contains four, 1 MSPS, input channel signals and an Open NAND Flash memory module with an analog to digital converter. The ADC, data bits, and control line signals from the board are sent to an Microsemi/Actel FPGA development kit for VHDL programming of the flash memory WRITE, READ, READ STATUS, ERASE, and RESET operation waveforms using Libero software. The debug board will be used for verification of the analog input signal and be able to communicate via serial interface with the module instrumentation. The scope of the new controller module was to find and develop an ONFI controller with the debug board layout designed and completed for manufacture. Successful flash memory operation waveform test routines were completed, simulated, and tested to work on the FPGA board. Through connection of the Flash/ADC board with the FPGA, it was found that the device specifications were not being meet with Vdd reaching half of its voltage. Further testing showed that it was the manufactured Flash/ADC board that contained a misalignment with the ONFI memory module traces. The errors proved to be too great to fix in the time limit set for the project.

High speed non-latching squid binary ripple counter

International Nuclear Information System (INIS)

Silver, A.H.; Phillips, R.R.; Sandell, R.D.

1985-01-01

High speed, single flux quantum (SFQ) binary scalers are important components in superconducting analog-to-digital converters (ADC). This paper reviews the concept for a SQUID ADC and the design of an SFQ binary ripple counter, and reports the simulation of key components, and fabrication and performance of non-latching SQUID scalers and SFQ binary ripple counters. The SQUIDs were fabricated with Nb/Nb 2 O 5 /PbIn junctions and interconnected by monolithic superconducting transmission lines and isolation resistors. Each SQUID functioned as a bistable flip-flop with the input connected to the center of the device and the output across one junction. All junctions were critically damped to optimize the pulse response. Operation was verified by observing the dc I-V curves of successive SQUIDs driven by a cw pulse train generated on the same chip. Each SQUID exhibited constant-voltage current steps at 1/2 the voltage of the preceding device as expected from the Josephson voltage-to-frequency relation. Steps were observed only for the same voltage polarity of successive devices and for proper phase bias of the SQUID. Binary frequency division was recorded up to 40GHz for devices designed to operate to 28GHz

A Novel Digital Background Calibration Technique for 16 bit SHA-less Multibit Pipelined ADC

Directory of Open Access Journals (Sweden)

Swina Narula

2016-01-01

Full Text Available In this paper, a high resolution of 16 bit and high speed of 125MS/s, multibit Pipelined ADC with digital background calibration is presented. In order to achieve low power, SHA-less front end is used with multibit stages. The first and second stages are used here as a 3.5 bit and the stages from third to seventh are of 2.5 bit and last stage is of 3-bit flash ADC. After bit alignment and truncation of total 19 bits, 16 bits are used as final digital output. To precise the remove linear gain error of the residue amplifier and capacitor mismatching error, a digital background calibration technique is used, which is a combination of signal dependent dithering (SDD and butterfly shuffler. To improve settling time of residue amplifier, a special circuit of voltage separation is used. With the proposed digital background calibration technique, the spurious-free dynamic range (SFDR has been improved to 97.74 dB @30 MHz and 88.9 dB @150 MHz, and the signal-to-noise and distortion ratio (SNDR has been improved to 79.77 dB @ 30 MHz, and 73.5 dB @ 150 MHz. The implementation of the Pipelined ADC has been completed with technology parameters of 0.18μm CMOS process with 1.8 V supply. Total power consumption is 300 mW by the proposed ADC.

Normalization of ADC does not improve correlation with overall survival in patients with high-grade glioma (HGG).

Science.gov (United States)

Qin, Lei; Li, Angie; Qu, Jinrong; Reinshagen, Katherine; Li, Xiang; Cheng, Su-Chun; Bryant, Annie; Young, Geoffrey S

2018-04-01

Mixed reports leave uncertainty about whether normalization of apparent diffusion coefficient (ADC) to a within-subject white matter reference is necessary for assessment of tumor cellularity. We tested whether normalization improves the previously reported correlation of resection margin ADC with 15-month overall survival (OS) in HGG patients. Spin-echo echo-planar DWI was retrieved from 3 T MRI acquired between maximal resection and radiation in 37 adults with new-onset HGG (25 glioblastoma; 12 anaplastic astrocytoma). ADC maps were produced with the FSL DTIFIT tool (Oxford Centre for Functional MRI). 3 neuroradiologists manually selected regions of interest (ROI) in normal appearing white matter (NAWM) and in non-enhancing tumor (NT) Normalized ADC (nADC) was computed as the ratio of absolute NT ADC to NAWM ADC. Reproducibility of nADC and absolute ADC among the readers' ROI was assessed using intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wCV). Correlations of ADC and nADC with OS were compared using receiver operating characteristics (ROC) analysis. A p value 0.05 was considered statistically significant. Both mean ADC and nADC differed significantly between patients subgrouped by 15-month OS (p = 0.0014 and 0.0073 respectively). wCV and ICC among the readers were similar for absolute and normalized ADC. In ROC analysis of correlation with OS, nADC did not perform significantly better than absolute ADC. Normalization does not significantly improve the correlation of absolute ADC with OS in HGG, suggesting that normalization is not necessary for clinical or research ADC analysis in HGG patients.

Reproducibility of brain ADC histograms

International Nuclear Information System (INIS)

Steens, S.C.A.; Buchem, M.A. van; Admiraal-Behloul, F.; Schaap, J.A.; Hoogenraad, F.G.C.; Wheeler-Kingshott, C.A.M.; Tofts, P.S.; Cessie, S. le

2004-01-01

The aim of this study was to assess the effect of differences in acquisition technique on whole-brain apparent diffusion coefficient (ADC) histogram parameters, as well as to assess scan-rescan reproducibility. Diffusion-weighted imaging (DWI) was performed in 7 healthy subjects with b-values 0-800, 0-1000, and 0-1500 s/mm 2 and fluid-attenuated inversion recovery (FLAIR) DWI with b-values 0-1000 s/mm 2 . All sequences were repeated with and without repositioning. The peak location, peak height, and mean ADC of the ADC histograms and mean ADC of a region of interest (ROI) in the white matter were compared using paired-sample t tests. Scan-rescan reproducibility was assessed using paired-sample t tests, and repeatability coefficients were reported. With increasing maximum b-values, ADC histograms shifted to lower values, with an increase in peak height (p<0.01). With FLAIR DWI, the ADC histogram shifted to lower values with a significantly higher, narrower peak (p<0.01), although the ROI mean ADC showed no significant differences. For scan-rescan reproducibility, no significant differences were observed. Different DWI pulse sequences give rise to different ADC histograms. With a given pulse sequence, however, ADC histogram analysis is a robust and reproducible technique. Using FLAIR DWI, the partial-voluming effect of cerebrospinal fluid, and thus its confounding effect on histogram analyses, can be reduced

Evaluation of Multi-Channel ADCs for Gamma-Ray Spectroscopy

Science.gov (United States)

Tan, Hui; Hennig, Wolfgang; Walby, Mark D.; Breus, Dimitry; Harris, Jackson

2013-04-01

As nuclear physicists increasingly design large scale experiments with hundreds or thousands of detector channels, there are growing needs for high density readout electronics with good timing and energy resolution that at the same time offer lower cost per channel compared to existing commercial solutions. Recent improvements in the design of commercial analog to digital converters (ADCs) have resulted in a variety of multi-channel ADCs that are natural choice for designing such high density readout modules. However, multi-channel ADCs typically are designed for medical imaging/ultrasound applications and therefore are not rated for their spectroscopic characteristics. In this work, we evaluated the gamma-ray spectroscopic performance of several multi-channel ADCs, including their energy resolution, nonlinearity, and timing resolution. Some of these ADCs demonstrated excellent energy resolution, 2.66% FWHM at 662 keV with a LaBr3 or 1.78 keV FWHM at 1332.5 keV with a high purity germanium (HPGe) detector, and sub-nanosecond timing resolution with LaBr 3. We present results from these measurements to illustrate their suitability for gamma-ray spectroscopy.

A low-power and small-area column-level ADC for high frame-rate CMOS pixel sensor

Energy Technology Data Exchange (ETDEWEB)

Zhang, L., E-mail: liang.zhang@iphc.cnrs.fr [School of Physics, Key Laboratory of Particle Physics and Particle Irradiation, Shandong University, 250100 Jinan (China); Institut Pluridisciplinaire Hubert Curien, University of Strasbourg, CNRS/IN2P3/UDS, 23 rue du loess, BP 28, 67037 Strasbourg (France); Morel, F.; Hu-Guo, C.; Hu, Y. [Institut Pluridisciplinaire Hubert Curien, University of Strasbourg, CNRS/IN2P3/UDS, 23 rue du loess, BP 28, 67037 Strasbourg (France)

2014-07-01

CMOS pixel sensors (CPS) have demonstrated performances meeting the specifications of the International Linear Collider (ILC) vertex detector (VTX). This paper presents a low-power and small-area 4-bit column-level analog-to-digital converter (ADC) for CMOS pixel sensors. The ADC employs a self-timed trigger and completes the conversion by performing a multi-bit/step approximation. As in the outer layers of the ILC vertex detector hit density is of the order of a few per thousand, in order to reduce power consumption, the ADC is designed to work in two modes: active mode and idle mode. The ADC is fabricated in a 0.35 μm CMOS process with a pixel pitch of 35 μm. It is implemented with 48 columns in a sensor prototype. Each column ADC covers an area of 35 ×545 μm{sup 2}. The measured temporal noise and Fixed Pattern Noise (FPN) are 0.96 mV and 0.40 mV, respectively. The power consumption, for a 3 V supply and 6.25 MS/s sampling rate, is 486 μW during idle time, which is by far the most frequently employed one. This value rises to 714 μW in the case of the active mode. The measured differential nonlinearity (DNL) and integral nonlinearity (INL) are 0.49/−0.28 LSB and 0.29/−0.20 LSB, respectively. - Highlights: • CMOS sensor integrated with column-level ADC is proposed for ILC VTX outer layers. • A low-power and small-area column-level ADC for high frame-rate CPS is presented. • The test results demonstrate the power and area efficiency. • The architecture is suitable for the outer layer CMOS sensors.

A low-power and small-area column-level ADC for high frame-rate CMOS pixel sensor

International Nuclear Information System (INIS)

Zhang, L.; Morel, F.; Hu-Guo, C.; Hu, Y.

2014-01-01

CMOS pixel sensors (CPS) have demonstrated performances meeting the specifications of the International Linear Collider (ILC) vertex detector (VTX). This paper presents a low-power and small-area 4-bit column-level analog-to-digital converter (ADC) for CMOS pixel sensors. The ADC employs a self-timed trigger and completes the conversion by performing a multi-bit/step approximation. As in the outer layers of the ILC vertex detector hit density is of the order of a few per thousand, in order to reduce power consumption, the ADC is designed to work in two modes: active mode and idle mode. The ADC is fabricated in a 0.35 μm CMOS process with a pixel pitch of 35 μm. It is implemented with 48 columns in a sensor prototype. Each column ADC covers an area of 35 ×545 μm 2 . The measured temporal noise and Fixed Pattern Noise (FPN) are 0.96 mV and 0.40 mV, respectively. The power consumption, for a 3 V supply and 6.25 MS/s sampling rate, is 486 μW during idle time, which is by far the most frequently employed one. This value rises to 714 μW in the case of the active mode. The measured differential nonlinearity (DNL) and integral nonlinearity (INL) are 0.49/−0.28 LSB and 0.29/−0.20 LSB, respectively. - Highlights: • CMOS sensor integrated with column-level ADC is proposed for ILC VTX outer layers. • A low-power and small-area column-level ADC for high frame-rate CPS is presented. • The test results demonstrate the power and area efficiency. • The architecture is suitable for the outer layer CMOS sensors

Accuracy Limitations of Pipelined ADCs

NARCIS (Netherlands)

Quinn, P.J.; Roermund, van A.H.M.

2005-01-01

In this paper, the key characteristics of the main errors which affect the performance of a switched capacitor pipelined ADC are presented and their effects on the ADC transfer characteristics demonstrated. Clear and concise relationships are developed to aid optimized design of the pipeline ADC and

The test ability of an adaptive pulse wave for ADC testing

NARCIS (Netherlands)

Sheng, Xiaoqin; Kerkhoff, Hans G.

2010-01-01

In the conventional ADC production test method, a high-quality analogue sine wave is applied to the Analogue-to-Digital Converter (ADC), which is expensive to generate. Nowadays, an increasing number of ADCs are integrated into a system-on-chip (SoC) platform design, which usually contains a digital

AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness.

Directory of Open Access Journals (Sweden)

Lindsey R Brown

Full Text Available Across bacterial species, metal binding proteins can serve functions in pathogenesis in addition to regulating metal homeostasis. We have compared and contrasted the activities of zinc (Zn2+-binding lipoproteins AdcA and AdcAII in the Streptococcus pneumoniae TIGR4 background. Exposure to Zn2+-limiting conditions resulted in delayed growth in a strain lacking AdcAII (ΔAdcAII when compared to wild type bacteria or a mutant lacking AdcA (ΔAdcA. AdcAII failed to interact with the extracellular matrix protein laminin despite homology to laminin-binding proteins of related streptococci. Deletion of AdcA or AdcAII led to significantly increased invasion of A549 human lung epithelial cells and a trend toward increased invasion in vivo. Loss of AdcAII, but not AdcA, was shown to negatively impact early colonization of the nasopharynx. Our findings suggest that expression of AdcAII affects invasiveness of S. pneumoniae in response to available Zn2+ concentrations.

A Dynamic Range Enhanced Readout Technique with a Two-Step TDC for High Speed Linear CMOS Image Sensors

Directory of Open Access Journals (Sweden)

Zhiyuan Gao

2015-11-01

Full Text Available This paper presents a dynamic range (DR enhanced readout technique with a two-step time-to-digital converter (TDC for high speed linear CMOS image sensors. A multi-capacitor and self-regulated capacitive trans-impedance amplifier (CTIA structure is employed to extend the dynamic range. The gain of the CTIA is auto adjusted by switching different capacitors to the integration node asynchronously according to the output voltage. A column-parallel ADC based on a two-step TDC is utilized to improve the conversion rate. The conversion is divided into coarse phase and fine phase. An error calibration scheme is also proposed to correct quantization errors caused by propagation delay skew within −Tclk~+Tclk. A linear CMOS image sensor pixel array is designed in the 0.13 μm CMOS process to verify this DR-enhanced high speed readout technique. The post simulation results indicate that the dynamic range of readout circuit is 99.02 dB and the ADC achieves 60.22 dB SNDR and 9.71 bit ENOB at a conversion rate of 2 MS/s after calibration, with 14.04 dB and 2.4 bit improvement, compared with SNDR and ENOB of that without calibration.

Comparison of apparent diffusion coefficients (ADCs) between two-point and multi-point analyses using high-B-value diffusion MR imaging

International Nuclear Information System (INIS)

Kubo, Hitoshi; Maeda, Masayuki; Araki, Akinobu

2001-01-01

We evaluated the accuracy of calculating apparent diffusion coefficients (ADCs) using high-B-value diffusion images. Echo planar diffusion-weighted MR images were obtained at 1.5 tesla in five standard locations in six subjects using gradient strengths corresponding to B values from 0 to 3000 s/mm 2 . Estimation of ADCs was made using two methods: a nonlinear regression model using measurements from a full set of B values (multi-point method) and linear estimation using B values of 0 and max only (two-point method). A high correlation between the two methods was noted (r=0.99), and the mean percentage differences were -0.53% and 0.53% in phantom and human brain, respectively. These results suggest there is little error in estimating ADCs calculated by the two-point technique using high-B-value diffusion MR images. (author)

High Performance ADC for Reconfigurable/Reprogrammable Communication Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Ridgetop Group will develop a 3X improvement in sampling resolution over current state-of-the art analog-to-digital converter (ADC) technology to support...

A 10 MS/s 8-bit charge-redistribution ADC for hybrid pixel applications in 65 m CMOS

International Nuclear Information System (INIS)

Kishishita, Tetsuichi; Hemperek, Tomasz; Krüger, Hans; Koch, Manuel; Germic, Leonard; Wermes, Norbert

2013-01-01

The design and measurement results of an 8-bit SAR ADC, based on a charge-redistribution DAC, are presented. This ADC is characterized by superior power efficiency and small area, realized by employing a lateral metal–metal capacitor array and a dynamic two-stage comparator. To avoid the need for a high-speed clock and its associated power consumption, an asynchronous logic was implemented in a logic control cell. A test chip has been developed in a 65 nm CMOS technology, including eight ADC channels with different layout flavors of the capacitor array, a transimpedance amplifier as a signal input structure, a serializer, and a custom-made LVDS driver for data transmission. The integral (INL) and differential (DNL) nonlinearities are measured below 0.5 LSB and 0.8 LSB, respectively, for the best channel operating at a sampling frequency of 10 MS/s. The area occupies 40μm×70μm for one ADC channel. The power consumption is estimated as 4μW at 1 MS/s and 38μW at 10 MS/s with a supply rail of 1.2 V. These excellent performance features and the natural radiation hardness of the design, due to the thin gate oxide thickness of transistors, are very interesting for front-end electronics ICs of future hybrid-pixel detector systems

A 10 MS/s 8-bit charge-redistribution ADC for hybrid pixel applications in 65 m CMOS

Energy Technology Data Exchange (ETDEWEB)

Kishishita, Tetsuichi, E-mail: kisisita@physik.uni-bonn.de; Hemperek, Tomasz; Krüger, Hans; Koch, Manuel; Germic, Leonard; Wermes, Norbert

2013-12-21

The design and measurement results of an 8-bit SAR ADC, based on a charge-redistribution DAC, are presented. This ADC is characterized by superior power efficiency and small area, realized by employing a lateral metal–metal capacitor array and a dynamic two-stage comparator. To avoid the need for a high-speed clock and its associated power consumption, an asynchronous logic was implemented in a logic control cell. A test chip has been developed in a 65 nm CMOS technology, including eight ADC channels with different layout flavors of the capacitor array, a transimpedance amplifier as a signal input structure, a serializer, and a custom-made LVDS driver for data transmission. The integral (INL) and differential (DNL) nonlinearities are measured below 0.5 LSB and 0.8 LSB, respectively, for the best channel operating at a sampling frequency of 10 MS/s. The area occupies 40μm×70μm for one ADC channel. The power consumption is estimated as 4μW at 1 MS/s and 38μW at 10 MS/s with a supply rail of 1.2 V. These excellent performance features and the natural radiation hardness of the design, due to the thin gate oxide thickness of transistors, are very interesting for front-end electronics ICs of future hybrid-pixel detector systems.

VHDL implementation on histogram with ADC CAMAC module

International Nuclear Information System (INIS)

Ruby Santhi, R.; Satyanarayana, V.V.V.; Ajith Kumar, B.P.

2007-01-01

Modern nuclear spectroscopy systems the data acquisition and analysis in experimental science have been undergoing major changes because of faster speed and higher resolution. The CAMAC module which is described here is FPGA based 8K x 24 bit Histogram Memory integrated with ADC on a single board has been designed and fabricated. This module accepts input from Spectroscopy Amplifier for Pulse Height Analysis and offers all features single spectra for a few selected parameters. These on line histograms are to monitor the progress of the experiments during on line experiments

A low-power small-area ADC array for IRFPA readout

Science.gov (United States)

Zhong, Shengyou; Yao, Libin

2013-09-01

The readout integrated circuit (ROIC) is a bridge between the infrared focal plane array (IRFPA) and image processing circuit in an infrared imaging system. The ROIC is the first part of signal processing circuit and connected to detectors directly, so its performance will greatly affect the detector or even the whole imaging system performance. With the development of CMOS technologies, it's possible to digitalize the signal inside the ROIC and develop the digital ROIC. Digital ROIC can reduce complexity of the whole system and improve the system reliability. More importantly, it can accommodate variety of digital signal processing techniques which the traditional analog ROIC cannot achieve. The analog to digital converter (ADC) is the most important building block in the digital ROIC. The requirements for ADCs inside the ROIC are low power, high dynamic range and small area. In this paper we propose an RC hybrid Successive Approximation Register (SAR) ADC as the column ADC for digital ROIC. In our proposed ADC structure, a resistor ladder is used to generate several voltages. The proposed RC hybrid structure not only reduces the area of capacitor array but also releases requirement for capacitor array matching. Theory analysis and simulation show RC hybrid SAR ADC is suitable for ADC array applications

Increase in speed of Wilkinson-type ADC and improvement of differential non-linearity

Energy Technology Data Exchange (ETDEWEB)

Kinbara, S [Japan Atomic Energy Research Inst., Tokai, Ibaraki. Tokai Research Establishment

1977-06-01

It is shown that the differential non-linearity of a Wilkinson-type analog-to-digital converter (ADC) is dominated by the unbalance of even-numbered periods caused by the action of interference resulting from operation of a channel scaler. To improve this situation, new methods were tested which allow such action of interference to be dispersed. Measurements show that a differential non-linearity value of +- 0.043% is attainable for a clock rate of 300 MHz.

A study of ADC value in PROPELLER DWI

International Nuclear Information System (INIS)

Naka, Takanori; Takahashi, Mitsuyuki

2009-01-01

Diffusion weighted imaging (DWI) is rapidly becoming widespread in MRI, with many reports of the differential diagnosis using the Apparent Diffusion Coefficient (ADC) being seen. We examined the influence of scan parameter on ADC in periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER)-DWI. Neither the repetition time (TR) nor T1 value had a major influence on the ADC value. Number of motion probing gradient (MPG) pulse, effective echo time (TE), and T2 value were the factors in which the ADC value was changed. In addition, the ADC value has been changed by the scan sequence. The factor that influenced the ADC value was able to be confirmed by this experiment. It is necessary to understand the influence that an individual factor has on ADC. (author)

Brookhaven FASTBUS ADC's

International Nuclear Information System (INIS)

Schmidt, M.P.; Black, J.K.; Blatt, S.R.

1983-01-01

A high energy physics experiment has been performed at Brookhaven National Laboratory on k/sub L/ 0 → 2π 0 decays employing a large (> 200 element) lead glass array as an electromagnetic calorimeter. To acquire pulse height information from the detector we have constructed ADC modules in the context of the Brookhaven Fastbus data acquisition system. Digitization (8 bits) and encoding, including pedestal subtraction and data sparsing, is achieved for each 16 channel module in 6 μsec

Two-step single slope/SAR ADC with error correction for CMOS image sensor.

Science.gov (United States)

Tang, Fang; Bermak, Amine; Amira, Abbes; Amor Benammar, Mohieddine; He, Debiao; Zhao, Xiaojin

2014-01-01

Conventional two-step ADC for CMOS image sensor requires full resolution noise performance in the first stage single slope ADC, leading to high power consumption and large chip area. This paper presents an 11-bit two-step single slope/successive approximation register (SAR) ADC scheme for CMOS image sensor applications. The first stage single slope ADC generates a 3-bit data and 1 redundant bit. The redundant bit is combined with the following 8-bit SAR ADC output code using a proposed error correction algorithm. Instead of requiring full resolution noise performance, the first stage single slope circuit of the proposed ADC can tolerate up to 3.125% quantization noise. With the proposed error correction mechanism, the power consumption and chip area of the single slope ADC are significantly reduced. The prototype ADC is fabricated using 0.18 μ m CMOS technology. The chip area of the proposed ADC is 7 μ m × 500 μ m. The measurement results show that the energy efficiency figure-of-merit (FOM) of the proposed ADC core is only 125 pJ/sample under 1.4 V power supply and the chip area efficiency is 84 k  μ m(2) · cycles/sample.

Two-Step Single Slope/SAR ADC with Error Correction for CMOS Image Sensor

Directory of Open Access Journals (Sweden)

Fang Tang

2014-01-01

Full Text Available Conventional two-step ADC for CMOS image sensor requires full resolution noise performance in the first stage single slope ADC, leading to high power consumption and large chip area. This paper presents an 11-bit two-step single slope/successive approximation register (SAR ADC scheme for CMOS image sensor applications. The first stage single slope ADC generates a 3-bit data and 1 redundant bit. The redundant bit is combined with the following 8-bit SAR ADC output code using a proposed error correction algorithm. Instead of requiring full resolution noise performance, the first stage single slope circuit of the proposed ADC can tolerate up to 3.125% quantization noise. With the proposed error correction mechanism, the power consumption and chip area of the single slope ADC are significantly reduced. The prototype ADC is fabricated using 0.18 μm CMOS technology. The chip area of the proposed ADC is 7 μm × 500 μm. The measurement results show that the energy efficiency figure-of-merit (FOM of the proposed ADC core is only 125 pJ/sample under 1.4 V power supply and the chip area efficiency is 84 k μm2·cycles/sample.

Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review.

Science.gov (United States)

Lambert, John M; Morris, Charles Q

2017-05-01

Attaching a cytotoxic "payload" to an antibody to form an antibody-drug conjugate (ADC) provides a mechanism for selective delivery of the cytotoxic agent to cancer cells via the specific binding of the antibody to cancer-selective cell surface molecules. The first ADC to receive marketing authorization was gemtuzumab ozogamicin, which comprises an anti-CD33 antibody conjugated to a highly potent DNA-targeting antibiotic, calicheamicin, approved in 2000 for treating acute myeloid leukemia. It was withdrawn from the US market in 2010 following an unsuccessful confirmatory trial. The development of two classes of highly potent microtubule-disrupting agents, maytansinoids and auristatins, as payloads for ADCs resulted in approval of brentuximab vedotin in 2011 for treating Hodgkin lymphoma and anaplastic large cell lymphoma, and approval of ado-trastuzumab emtansine in 2013 for treating HER2-positive breast cancer. Their success stimulated much research into the ADC approach, with >60 ADCs currently in clinical evaluation, mostly targeting solid tumors. Five ADCs have advanced into pivotal clinical trials for treating various solid tumors-platinum-resistant ovarian cancer, mesothelioma, triple-negative breast cancer, glioblastoma, and small cell lung cancer. The level of target expression is a key parameter in predicting the likelihood of patient benefit for all these ADCs, as well as for the approved compound, ado-trastuzumab emtansine. The development of a patient selection strategy linked to target expression on the tumor is thus critically important for identifying the population appropriate for receiving treatment.

A 14-bit 30-MS/s 38-mW SAR ADC using noise filter gear shifting

NARCIS (Netherlands)

Kramer, Martin; Janssen, Erwin; Doris, Kostas; Murmann, Boris

2017-01-01

We present a successive approximation register analog-to-digital converter (ADC) that employs a comparator with time-varying noise performance, realized by changing the integration time of a Gm-C preamplifier. This approach allows us to relax precision and enhance speed during noncritical decisions,

Comparison of Absolute Apparent Diffusion Coefficient (ADC) Values in ADC Maps Generated Across Different Postprocessing Software: Reproducibility in Endometrial Carcinoma.

Science.gov (United States)

Ghosh, Adarsh; Singh, Tulika; Singla, Veenu; Bagga, Rashmi; Khandelwal, Niranjan

2017-12-01

Apparent diffusion coefficient (ADC) maps are usually generated by builtin software provided by the MRI scanner vendors; however, various open-source postprocessing software packages are available for image manipulation and parametric map generation. The purpose of this study is to establish the reproducibility of absolute ADC values obtained using different postprocessing software programs. DW images with three b values were obtained with a 1.5-T MRI scanner, and the trace images were obtained. ADC maps were automatically generated by the in-line software provided by the vendor during image generation and were also separately generated on postprocessing software. These ADC maps were compared on the basis of ROIs using paired t test, Bland-Altman plot, mountain plot, and Passing-Bablok regression plot. There was a statistically significant difference in the mean ADC values obtained from the different postprocessing software programs when the same baseline trace DW images were used for the ADC map generation. For using ADC values as a quantitative cutoff for histologic characterization of tissues, standardization of the postprocessing algorithm is essential across processing software packages, especially in view of the implementation of vendor-neutral archiving.

Interpolation algorithm for asynchronous ADC-data

Directory of Open Access Journals (Sweden)

S. Bramburger

2017-09-01

Full Text Available This paper presents a modified interpolation algorithm for signals with variable data rate from asynchronous ADCs. The Adaptive weights Conjugate gradient Toeplitz matrix (ACT algorithm is extended to operate with a continuous data stream. An additional preprocessing of data with constant and linear sections and a weighted overlap of step-by-step into spectral domain transformed signals improve the reconstruction of the asycnhronous ADC signal. The interpolation method can be used if asynchronous ADC data is fed into synchronous digital signal processing.

A 10 bit 200 MS/s pipeline ADC using loading-balanced architecture in 0.18 μm CMOS

Science.gov (United States)

Wang, Linfeng; Meng, Qiao; Zhi, Hao; Li, Fei

2017-07-01

A new loading-balanced architecture for high speed and low power consumption pipeline analog-to-digital converter (ADC) is presented in this paper. The proposed ADC uses SHA-less, op-amp and capacitor-sharing technique, capacitor-scaling scheme to reduce the die area and power consumption. A new capacitor-sharing scheme was proposed to cancel the extra reset phase of the feedback capacitors. The non-standard inter-stage gain increases the feedback factor of the first stage and makes it equal to the second stage, by which, the load capacitor of op-amp shared by the first and second stages is balanced. As for the fourth stage, the capacitor and op-amp no longer scale down. From the system’s point of view, all load capacitors of the shared OTAs are balanced by employing a loading-balanced architecture. The die area and power consumption are optimized maximally. The ADC is implemented in a 0.18 μm 1P6M CMOS technology, and occupies a die area of 1.2 × 1.2 mm{}2. The measurement results show a 55.58 dB signal-to-noise-and-distortion ratio (SNDR) and 62.97 dB spurious-free dynamic range (SFDR) with a 25 MHz input operating at a 200 MS/s sampling rate. The proposed ADC consumes 115 mW at 200 MS/s from a 1.8 V supply.

Fast high resolution ADC based on the flash type with a special error correcting technique

Energy Technology Data Exchange (ETDEWEB)

Xiao-Zhong, Liang; Jing-Xi, Cao [Beijing Univ. (China). Inst. of Atomic Energy

1984-03-01

A fast 12 bits ADC based on the flash type with a simple special error correcting technique which can effectively compensate the level drift of the discriminators and the droop of the stretcher voltage is described. The DNL is comparable with the Wilkinson's ADC and long term drift is far better than its.

Adjustable Nyquist-rate System for Single-Bit Sigma-Delta ADC with Alternative FIR Architecture

Science.gov (United States)

Frick, Vincent; Dadouche, Foudil; Berviller, Hervé

2016-09-01

This paper presents a new smart and compact system dedicated to control the output sampling frequency of an analogue-to-digital converters (ADC) based on single-bit sigma-delta (ΣΔ) modulator. This system dramatically improves the spectral analysis capabilities of power network analysers (power meters) by adjusting the ADC's sampling frequency to the input signal's fundamental frequency with a few parts per million accuracy. The trade-off between straightforwardness and performance that motivated the choice of the ADC's architecture are preliminary discussed. It particularly comes along with design considerations of an ultra-steep direct-form FIR that is optimised in terms of size and operating speed. Thanks to compact standard VHDL language description, the architecture of the proposed system is particularly suitable for application-specific integrated circuit (ASIC) implementation-oriented low-power and low-cost power meter applications. Field programmable gate array (FPGA) prototyping and experimental results validate the adjustable sampling frequency concept. They also show that the system can perform better in terms of implementation and power capabilities compared to dedicated IP resources.

ADC mapping of benign and malignant breast tumors

International Nuclear Information System (INIS)

Woodhams, R.; Matsunaga, Keiji; Kan, Shinichi; Hata, Hirofumi; Iwabuchi, Keiichi; Kuranami, Masaru; Watanabe, Masahiko; Hayakawa, Kazushige; Ozaki, Masanori

2005-01-01

The purpose of this study was to investigate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) value in differentiating benign and malignant breast lesions and evaluating the detection accuracy of the cancer extension. We used DWI to obtain images of 191 benign and malignant lesions (24 benign, 167 malignant) before surgical excision. The ADC values of the benign and malignant lesions were compared, as were the values of noninvasive ductal carcinoma (NIDC) and invasive ductal carcinoma (IDC). We also evaluated the ADC map, which represents the distribution of ADC values, and compared it with the cancer extension. The mean ADC value of each type of lesion was as follows: malignant lesions, 1.22±0.31 x 10 -3 mm 2 /s; benign lesions, 1.67±0.54 x 10 -3 mm 2 /s; normal tissues, 2.09±0.27 x 10 -3 mm 2 /s. The mean ADC value of the malignant lesions was statistically lower than that of the benign lesions and normal breast tissues. The ADC value of IDC was statistically lower than that of NIDC. The sensitivity of the ADC value for malignant lesions with a threshold of less than 1.6 x 10 -3 mm 2 /s was 95% and the specificity was 46%. A full 75% of all malignant cases exhibited a near precise distribution of low ADC values on ADC maps to describe malignant lesions. The main causes of false negative and underestimation of cancer spread were susceptibility artifact because of bleeding and tumor structure. Major histologic types of false-positive lesions were intraductal papilloma and fibrocystic diseases. Fibrocystic diseases also resulted in overestimation of cancer extension. DWI has the potential in clinical appreciation to detect malignant breast tumors and support the evaluation of tumor extension. However, the benign proliferative change remains to be studied as it mimics the malignant phenomenon on the ADC map. (author)

Diagnostic value of ADC in patients with prostate cancer: influence of the choice of b values.

Science.gov (United States)

Thörmer, Gregor; Otto, Josephin; Reiss-Zimmermann, Martin; Seiwerts, Matthias; Moche, Michael; Garnov, Nikita; Franz, Toni; Do, Minh; Stolzenburg, Jens-Uwe; Horn, Lars-Christian; Kahn, Thomas; Busse, Harald

2012-08-01

To evaluate the influence of the choice of b values on the diagnostic value of the apparent diffusion coefficient (ADC) for detection and grading of prostate cancer (PCa). Forty-one patients with biopsy-proven PCa underwent endorectal 3-T MRI before prostatectomy. Different combinations of b values (0-800 s/mm(2)) were used to calculate four representative ADC maps. Mean ADCs of tumours and non-malignant tissue were determined. Tumour appearance on different ADC maps was rated by three radiologists as good, fair or poor by assigning a visual score (VS) of 2, 1 or 0, respectively. Differences in the ADC values with the choice of b values were analysed using one-way ANOVA. Choice of b values had a highly (P < 0.001) significant influence on the absolute ADC in each tissue. Maps using b = [50, 800] and [0, 800] were rated best (VS= 1.6 ± 0.3) and second best (1.1 ± 0.3, P < 0.001), respectively. For low-grade carcinomas (Gleason score ≤ 6, 13/41 patients), only the former choice received scores better than fair (VS = 1.4 ± 0.3). Mean tumour ADCs showed significant negative correlation (Spearman's ρ -0.38 to -0.46, P < 0.05) with Gleason score. Absolute ADC values strongly depend on the choice of b values and therefore should be used with caution for diagnostic purposes. A minimum b value greater than zero is recommended for ADC calculation to improve the visual assessment of PCa in ADC maps. • Absolute ADC values are highly dependent on the choice of b values. • Absolute ADC thresholds should be used carefully to predict tumour aggressiveness. • Subjective ratings of ADC maps involving b = 0 s/mm ( 2 ) are poor to fair. • Minimum b value greater than 0 s/mm ( 2 ) is recommended for ADC calculation.

A Contribution to Nyquist-Rate ADC Modeling - Detailed Algorithm Description

Directory of Open Access Journals (Sweden)

J. Zidek

2012-04-01

Full Text Available In this article, the innovative ADC modeling algorithm is described. It is well suitable for nyquist-rate ADC error back annotation. This algorithm is the next step of building a support tool for IC design engineers. The inspiration for us was the work [2]. Here, the ADC behavior is divided into HCF (High Code Frequency and LCF (Low Code Frequency separated independent parts. This paper is based on the same concept but the model coefficients are estimated in a different way only from INL data. The HCF order recognition part was newly added as well. Thanks to that the HCF coefficients number is lower in comparison with the original Grimaldi’s work (especially for converters with low ratio between HCF and “random” part of INL. Modeling results are demonstrated on a real data set measured by ASICentrum on chargeredistribution type SAR ADC chip. Results are showed not only by coefficient values but also by the Model Coverage metrics. Model limitations are also discussed.

Different methods of measuring ADC values in normal human brain

International Nuclear Information System (INIS)

Wei Youping; Sheng Junkang; Zhang Caiyuan

2009-01-01

Objective: To investigate better method of measuring ADC values of normal brain, and provide reference for further research. Methods: Twenty healthy people's MR imaging were reviewed. All of them underwent routine MRI scans and echo-planar diffusion-weighted imaging (DWI), and ADC maps were reconstructed on work station. Six regions of interest (ROI) were selected for each object, the mean ADC values were obtained for each position on DWI and ADC maps respectively. Results: On the anisotropic DWI map calculated in the hypothalamus, ADC M , ADC P , ADC S values were no significant difference (P>0.05), in the frontal white matter and internal capsule hindlimb, there was a significant difference (P ave value exist significant difference to direct measurement on the anisotropic (isotropic) ADC map (P<0.001). Conclusion: Diffusion of water in the frontal white matter and internal capsule are anisotropic, but it is isotropic in the hypothalamus; different quantitative methods of diffusion measurement of 4ADC values have significant difference, but ADC values calculated through the DWI map is more accurate, quantitative diffusion study of brain tissue should also consider the diffusion measurement method. (authors)

Basic Block of Pipelined ADC Design Requirements

Directory of Open Access Journals (Sweden)

V. Kledrowetz

2011-04-01

Full Text Available The paper describes design requirements of a basic stage (called MDAC - Multiplying Digital-to- Analog Converter of a pipelined ADC. There exist error sources such as finite DC gain of opamp, capacitor mismatch, thermal noise, etc., arising when the switched capacitor (SC technique and CMOS technology are used. These non-idealities are explained and their influences on overall parameters of a pipelined ADC are studied. The pipelined ADC including non-idealities was modeled in MATLAB - Simulink simulation environment.

A 0.9-V 12-bit 40-MSPS Pipeline ADC for Wireless Receivers

Science.gov (United States)

Ito, Tomohiko; Itakura, Tetsuro

A 0.9-V 12-bit 40-MSPS pipeline ADC with I/Q amplifier sharing technique is presented for wireless receivers. To achieve high linearity even at 0.9-V supply, the clock signals to sampling switches are boosted over 0.9V in conversion stages. The clock-boosting circuit for lifting these clocks is shared between I-ch ADC and Q-ch ADC, reducing the area penalty. Low supply voltage narrows the available output range of the operational amplifier. A pseudo-differential (PD) amplifier with two-gain-stage common-mode feedback (CMFB) is proposed in views of its wide output range and power efficiency. This ADC is fabricated in 90-nm CMOS technology. At 40MS/s, the measured SNDR is 59.3dB and the corresponding effective number of bits (ENOB) is 9.6. Until Nyquist frequency, the ENOB is kept over 9.3. The ADC dissipates 17.3mW/ch, whose performances are suitable for ADCs for mobile wireless systems such as WLAN/WiMAX.

A low power cyclic ADC design for a wireless monitoring system for orthopedic implants

Energy Technology Data Exchange (ETDEWEB)

Chen Yi; Li Fule; Chen Hong; Zhang Chun; Wang Zhihua, E-mail: chenyi02@mails.tsinghua.edu.c [Tsinghua National Laboratory for Information Science and Technology, Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

2009-08-15

This paper presents a low power cyclic analog-to-digital convertor (ADC) design for a wireless monitoring system for orthopedic implants. A two-stage cyclic structure including a single to differential converter, two multiplying DAC functional blocks (MDACs) and some comparators is adopted, which brings moderate speed and moderate resolution with low power consumption. The MDAC is implemented with the common switched capacitor method. The 1.5-bit stage greatly simplifies the design of the comparator. The operational amplifier is carefully optimized both in schematic and layout for low power and offset. The prototype chip has been fabricated in a United Microelectronics Corporation (UMC) 0.18-{mu}m 1P6M CMOS process. The core of the ADC occupies only 0.12 mm{sup 2}. With a 304.7-Hz input and 4-kHz sampling rate, the measured peak SNDR and SFDR are 47.1 dB and 57.8 dBc respectively and its DNL and INL are 0.27 LSB and 0.3 LSB, respectively. The power consumption of the ADC is only 12.5 {mu}W in normal working mode and less than 150 nW in sleep mode. (semiconductor integrated circuits)

High-speed data acquisition with the Solaris and Linux operating systems

International Nuclear Information System (INIS)

Zilker, M.; Heimann, P.

2000-01-01

In this paper, we discuss whether Solaris and Linux are suitable for data acquisition systems in soft real time conditions. As an example we consider a plasma diagnostic (Mirnov coils), which collects data for a complete plasma discharge of about 10 s from up to 72 channels. Each ADC-Channel generates a data stream of 4 MB/s. To receive these data streams an eight-channel Hotlink PCI interface board was designed. With a prototype system using Solaris and the driver developed by us we investigate important properties of the operating system such as the I/O performance and scheduling of processes. We compare the Solaris operating system on the Ultra Sparc platform with Linux on the Intel platform. Finally, some points of user program development are mentioned to show how the application can make the most efficient use of the underlying high-speed I/O system

Flexible high-speed FASTBUS master for data read-out and preprocessing

International Nuclear Information System (INIS)

Wurz, A.; Manner, R.

1990-01-01

This paper describes a single slot FASTBUS master module. It can be used for read-out and preprocessing of data that are read out from FASTBUS modules, e.g., and ADC system. The module consists of a 25 MHz, 32-bit processor MC 68030 with cache memory and memory management, a floating point coprocessor MC68882, 4 MBytes of main memory, and FASTBUS master and slave interfaces. In addition, a DMA controller for read-out of FASTBUS data is provided. The processor allows I/O via serial ports, a 16-bit parallel port, and a transputer link. Additional interfaces are planned. The main memory is multi-ported and can be accessed directly by the CPU, the FASTBUS, and external masters via the high-speed local bus that is accessible by way of a connector. The FASTBUS interface supports most of the standard operations in master and slave mode

An 'ADC-Memory' system based on a new principle in data access

International Nuclear Information System (INIS)

Pan Dajing; Wu Yongqing; Wang Shibo

1990-01-01

A new kind of 'ADC-Memory' (ADC-M) with real time correction of counting loss in dead time is now used in a multiuser data acquisition and processing system based on DUAL/68000 microcomputer. In data access, it replaces the 'DMA + 1' in classical MCA with the new method 'DMA + N', where N is weight factor of correction. The new method is based on the principle of virtual pulse generator. This method is superior to the correction by the software because the correction needn't take the computer time. Thus, this ADC-M can be used in the counting of high rate pulses

Increasing the Accuracy of Volume and ADC Delineation for Heterogeneous Tumor on Diffusion-Weighted MRI: Correlation with PET/CT

Energy Technology Data Exchange (ETDEWEB)

Gong, Nan-Jie [Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong (China); Wong, Chun-Sing, E-mail: drcswong@gmail.com [Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong (China); Chu, Yiu-Ching [Department of Radiology, Kwong Wah Hospital, Hong Kong (China); Guo, Hua [Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing (China); Huang, Bingsheng [Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong (China); Chan, Queenie [Philips Healthcare, Hong Kong (China)

2013-10-01

Purpose: To improve the accuracy of volume and apparent diffusion coefficient (ADC) measurements in diffusion-weighted magnetic resonance imaging (MRI), we proposed a method based on thresholding both the b0 images and the ADC maps. Methods and Materials: In 21 heterogeneous lesions from patients with metastatic gastrointestinal stromal tumors (GIST), gross lesion were manually contoured, and corresponding volumes and ADCs were denoted as gross tumor volume (GTV) and gross ADC (ADC{sub g}), respectively. Using a k-means clustering algorithm, the probable high-cellularity tumor tissues were selected based on b0 images and ADC maps. ADC and volume of the tissues selected using the proposed method were denoted as thresholded ADC (ADC{sub thr}) and high-cellularity tumor volume (HCTV), respectively. The metabolic tumor volume (MTV) in positron emission tomography (PET)/computed tomography (CT) was measured using 40% maximum standard uptake value (SUV{sub max}) as the lower threshold, and corresponding mean SUV (SUV{sub mean}) was also measured. Results: HCTV had excellent concordance with MTV according to Pearson's correlation (r=0.984, P<.001) and linear regression (slope = 1.085, intercept = −4.731). In contrast, GTV overestimated the volume and differed significantly from MTV (P=.005). ADC{sub thr} correlated significantly and strongly with SUV{sub mean} (r=−0.807, P<.001) and SUV{sub max} (r=−0.843, P<.001); both were stronger than those of ADC{sub g}. Conclusions: The proposed lesion-adaptive semiautomatic method can help segment high-cellularity tissues that match hypermetabolic tissues in PET/CT and enables more accurate volume and ADC delineation on diffusion-weighted MR images of GIST.

Endometrial cancer: correlation of apparent diffusion coefficient (ADC) with tumor cellularity and tumor grade.

Science.gov (United States)

Kishimoto, Keiko; Tajima, Shinya; Maeda, Ichiro; Takagi, Masayuki; Ueno, Takahiko; Suzuki, Nao; Nakajima, Yasuo

2016-08-01

Diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) are widely used for detecting uterine endometrial cancer. The relationships between ADC values and pathological features of endometrial cancer have not yet been established. To investigate whether ADC values of endometrial cancer vary according to histologic tumor cellularity and tumor grade. We retrospectively reviewed 30 pathologically confirmed endometrial cancers. All patients underwent conventional non-enhanced magnetic resonance imaging (MRI) and DWI procedures, and ADC values were calculated. Tumor cellularity was evaluated by counting cancer cells in three high-power ( × 400) fields. The correlation between ADC values and tumor cellularity was assessed using Pearson's correlation coefficient test for statistical analysis. The mean ± standard deviation (SD) ADC value ( ×10(-3) mm(2)/s) of endometrial cancer was 0.85 ± 0.22 (range, 0.55-1.71). The mean ± SD tumor cellularity was 528.36 ± 16.89 (range, 298.0-763.6). ADC values were significantly inversely correlated with tumor cellularity. No significant relationship was observed between ADC values and tumor grade (mean ADC values: G1, 0.88 ± 0.265 × 10(-3) mm(2)/s; G2, 0.80 ± 0.178 × 10(-3) mm(2)/s; G3, 0.81 ± 0.117 × 10(-3) mm(2)/s). There is a significant inverse relationship between ADC values and tumor cellularity in endometrial cancer. No significant differences in average ADC value were observed between G1, G2, and G3 tumors. However, the lower the tumor grade, the wider the SD. © The Foundation Acta Radiologica 2015.

High speed atom source

International Nuclear Information System (INIS)

Hoshino, Hitoshi.

1990-01-01

In a high speed atom source, since the speed is not identical between ions and electrons, no sufficient neutralizing effect for ionic rays due to the mixing of the ionic rays and the electron rays can be obtained failing to obtain high speed atomic rays at high density. In view of the above, a speed control means is disposed for equalizing the speed of ions forming ionic rays and the speed of electrons forming electron rays. Further, incident angle of the electron rays and/or ionic rays to a magnet or an electrode is made variable. As a result, the relative speed between the ions and the electrons to the processing direction is reduced to zero, in which the probability of association between the ions and the electrons due to the coulomb force is increased to improve the neutralizing efficiency to easily obtain fine and high density high speed electron rays. Further, by varying the incident angle, a track capable of obtaining an ideal mixing depending on the energy of the neutralized ionic rays is formed. Since the high speed electron rays has such high density, they can be irradiated easily to the minute region of the specimen. (N.H.)

Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values

Energy Technology Data Exchange (ETDEWEB)

Bickel, Hubert; Pinker, Katja; Polanec, Stephan; Magometschnigg, Heinrich; Wengert, Georg; Spick, Claudio; Helbich, Thomas H.; Baltzer, Pascal [Medical University Vienna, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Vienna (Austria); Bogner, Wolfgang [Medical University Vienna - MR Center of Excellence, Department of Biomedical Imaging and Image-Guided Therapy, Vienna (Austria); Bago-Horvath, Zsuzsanna [Medical University Vienna, Department of Pathology, Vienna (Austria)

2017-05-15

To investigate the influence of region-of-interest (ROI) placement and different apparent diffusion coefficient (ADC) parameters on ADC values, diagnostic performance, reproducibility and measurement time in breast tumours. In this IRB-approved, retrospective study, 149 histopathologically proven breast tumours (109 malignant, 40 benign) in 147 women (mean age 53.2) were investigated. Three radiologists independently measured minimum, mean and maximum ADC, each using three ROI placement approaches:1 - small 2D-ROI, 2 - large 2D-ROI and 3 - 3D-ROI covering the whole lesion. One reader performed all measurements twice. Median ADC values, diagnostic performance, reproducibility, and measurement time were calculated and compared between all combinations of ROI placement approaches and ADC parameters. Median ADC values differed significantly between the ROI placement approaches (p <.001). Minimum ADC showed the best diagnostic performance (AUC.928-.956), followed by mean ADC obtained from 2D ROIs (.926-.94). Minimum and mean ADC showed high intra- (ICC.85-.94) and inter-reader reproducibility (ICC.74-.94). Median measurement time was significantly shorter for the 2D ROIs (p <.001). ROI placement significantly influences ADC values measured in breast tumours. Minimum and mean ADC acquired from 2D-ROIs are useful for the differentiation of benign and malignant breast lesions, and are highly reproducible, with rapid measurement. (orig.)

A digital calibration technique for an ultra high-speed wide-bandwidth folding and interpolating analog-to-digital converter in 0.18-{mu}m CMOS technology

Energy Technology Data Exchange (ETDEWEB)

Yu Jinshan; Zhang Ruitao; Zhang Zhengping; Wang Yonglu; Zhu Can; Zhang Lei; Yu Zhou; Han Yong, E-mail: yujinshan@yeah.net [National Laboratory of Analog IC' s, Chongqing 400060 (China)

2011-01-15

A digital calibration technique for an ultra high-speed folding and interpolating analog-to-digital converter in 0.18-{mu}m CMOS technology is presented. The similar digital calibration techniques are taken for high 3-bit flash converter and low 5-bit folding and interpolating converter, which are based on well-designed calibration reference, calibration DAC and comparators. The spice simulation and the measured results show the ADC produces 5.9 ENOB with calibration disabled and 7.2 ENOB with calibration enabled for high-frequency wide-bandwidth analog input. (semiconductor integrated circuits)

HVM die yield improvement as a function of DRSEM ADC

Science.gov (United States)

Maheshwary, Sonu; Haas, Terry; McGarvey, Steve

2010-03-01

Given the current manufacturing technology roadmap and the competitiveness of the global semiconductor manufacturing environment in conjunction with the semiconductor manufacturing market dynamics, the market place continues to demand a reduced die manufacturing cost. This continuous pressure on lowering die cost in turn drives an aggressive yield learning curve, a key component of which is defect reduction of manufacturing induced anomalies. In order to meet and even exceed line and die yield targets there is a need to revamp defect classification strategies and place a greater emphasize on increasing the accuracy and purity of the Defect Review Scanning Electron Microscope (DRSEM) Automated Defect Classification (ADC) results while placing less emphasis on the ADC results of patterned/un-patterned wafer inspection systems. The increased emphasis on DRSEM ADC results allows for a high degree of automation and consistency in the classification data and eliminates variance induced by the manufacturing staff. This paper examines the use of SEM based Auto Defect Classification in a high volume manufacturing environment as a key driver in the reduction of defect limited yields.

LDRD final report: photonic analog-to-digital converter (ADC) technology; TOPICAL

International Nuclear Information System (INIS)

Bowers, M; Deri, B; Haigh, R; Lowry, M; Sargis, P; Stafford, R; Tong, T

1999-01-01

We report on an LDRD seed program of novel technology development (started by an FY98 Engineering Tech-base project) that will enable extremely high-fidelity analog-to-digital converters for a variety of national security missions. High speed (l0+ GS/s ), high precision (l0+ bits) ADC technology requires extremely short aperture times ((approx)1ps ) with very low jitter requirements (sub 10fs ). These fundamental requirements, along with other technological barriers, are difficult to realize with electronics: However, we outline here, a way to achieve these timing apertures using a novel multi-wavelength optoelectronic short-pulse optical source. Our approach uses an optoelectronic feedback scheme with high optical Q to produce an optical pulse train with ultra-low jitter ( sub 5fs) and high amplitude stability ( and lt;10(sup 10)). This approach requires low power and can be integrated into an optoelectronic integrated circuit to minimize the size. Under this seed program we have demonstrated that the optical feedback mechanism can be used to generate a high Q resonator. This has reduced the technical risk for further development, making it an attractive candidate for outside funding

An undersampling 14-bit cyclic ADC with over 100-dB SFDR

Energy Technology Data Exchange (ETDEWEB)

Li Weitao; Li Fule; Guo Dandan; Zhang Chun; Wang Zhihua, E-mail: liwt07@mails.tsinghua.edu.c [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

2010-02-15

A high linearity, undersampling 14-bit 357 kSps cyclic analog-to-digital convert (ADC) is designed for a radio frequency identification transceiver system. The passive capacitor error-average (PCEA) technique is adopted for high accuracy. An improved PCEA sampling network, capable of eliminating the crosstalk path of two pipelined stages, is employed. Opamp sharing and the removal of the front-end sample and hold amplifier are utilized for low power dissipation and small chip area. An additional digital calibration block is added to compensate for the error due to defective layout design. The presented ADC is fabricated in a 180 nm CMOS process, occupying 0.65 x 1.6 mm{sup 2}. The input of the undersampling ADC achieves 15.5 MHz with more than 90 dB spurious free dynamic range (SFDR), and the peak SFDR is as high as 106.4 dB with 2.431 MHz input. (semiconductor integrated circuits)

Cerebral and cerebellar ADC values during a migraine attack

Energy Technology Data Exchange (ETDEWEB)

Degirmenci, Bumin; Haktanir, Alpay; Albayrak, Ramazan; Acar, Murat [University of Kocatepe, Department of Radiology, Faculty of Medicine, Afyon (Turkey); Yaman, Mehmet [University of Kocatepe, Department of Neurology, Faculty of Medicine, Afyon (Turkey)

2007-05-15

We investigated the diffusion-weighted MRI changes, apparent diffusion coefficient (ADC) values, and conventional MRI findings in specific brain areas during migraine attacks in patients with and without aura. Included in the study were 22 patients (2 male, 20 female) aged between 17 and 49 years who were diagnosed as having migraine according to the diagnostic criteria of the International Headache Society. Also included in the study were 18 age- and sex-matched healthy volunteers. Hyperintense lesions were evaluated in conventional MR images. Heavily diffusion-weighted images, ADC maps, and segmented ADC maps generated for regional ADC (rADC) measurements, were also studied. ADC values from specific brain areas were used with appropriate region of interests (ROI). Migraine with aura was diagnosed in 13 patients and migraine without aura was diagnosed in 9 patients. A total of 23 hyperintense lesions within the periventricular white matter and deep white matter were detected in five patients (21.8%). All of these hyperintense lesions were seen in migraine patients with aura. In only one patient did a hyperintense lesion show an increased diffusion pattern on diffusion-weighted images and ADC maps. One hyperintense lesion was detected in the control group (5.5%). There was no significant difference in ADC values between the migraine and control groups. T2-weighted hyperintense lesions were significantly more frequent in migraine patients especially in those with aura than in the control group. No diffusion alterations in diffusion-weighted images were detected in the infra- and supratentorial brain areas during migraine attacks in patients with and without aura. (orig.)

Cerebral and cerebellar ADC values during a migraine attack

International Nuclear Information System (INIS)

Degirmenci, Bumin; Haktanir, Alpay; Albayrak, Ramazan; Acar, Murat; Yaman, Mehmet

2007-01-01

We investigated the diffusion-weighted MRI changes, apparent diffusion coefficient (ADC) values, and conventional MRI findings in specific brain areas during migraine attacks in patients with and without aura. Included in the study were 22 patients (2 male, 20 female) aged between 17 and 49 years who were diagnosed as having migraine according to the diagnostic criteria of the International Headache Society. Also included in the study were 18 age- and sex-matched healthy volunteers. Hyperintense lesions were evaluated in conventional MR images. Heavily diffusion-weighted images, ADC maps, and segmented ADC maps generated for regional ADC (rADC) measurements, were also studied. ADC values from specific brain areas were used with appropriate region of interests (ROI). Migraine with aura was diagnosed in 13 patients and migraine without aura was diagnosed in 9 patients. A total of 23 hyperintense lesions within the periventricular white matter and deep white matter were detected in five patients (21.8%). All of these hyperintense lesions were seen in migraine patients with aura. In only one patient did a hyperintense lesion show an increased diffusion pattern on diffusion-weighted images and ADC maps. One hyperintense lesion was detected in the control group (5.5%). There was no significant difference in ADC values between the migraine and control groups. T2-weighted hyperintense lesions were significantly more frequent in migraine patients especially in those with aura than in the control group. No diffusion alterations in diffusion-weighted images were detected in the infra- and supratentorial brain areas during migraine attacks in patients with and without aura. (orig.)

A Continuous-Time Delta-Sigma ADC for Portable Ultrasound Scanners

DEFF Research Database (Denmark)

Llimos Muntal, Pere; Jørgensen, Ivan Harald Holger; Bruun, Erik

2017-01-01

A fully differential fourth-order 1-bit continuous-time delta-sigma ADC designed in a 65nm process for portable ultrasound scanners is presented in this paper. The circuit design, implementation and measurements on the fabricated die are shown. The loop filter consists of RC-integrators, programmable...... capacitor arrays, resistors and voltage feedback DACs. The quantizer contains a pulse generator, a high-speed clocked comparator and a pull-down clocked latch to ensure constant delay in the feedback loop. Using this implementation, a small and low-power solution required for portable ultrasound scanner...... applications is achieved. The converter has a supply voltage of 1.2V, a bandwidth of 10MHz and an oversampling ratio of 16 leading to an operating frequency of 320MHz. The design occupies a die area of 0.0175mm2. Simulations with extracted parasitics show a SNR of 45.2dB and a current consumption of 489 µ...

Very High-Performance Advanced Filter Bank Analog-to-Digital Converter (AFB ADC) Project

National Research Council Canada - National Science Library

Velazquez, Scott

1999-01-01

... of the art by using a parallel array of individual commercial off the shelf converters. The significant performance improvements afforded by the Advanced Filter Bank Analog to Digital Converter (AFB ADC...

12-bit 32 channel 500 MS/s low-latency ADC for particle accelerators real-time control

Science.gov (United States)

Karnitski, Anton; Baranauskas, Dalius; Zelenin, Denis; Baranauskas, Gytis; Zhankevich, Alexander; Gill, Chris

2017-09-01

Particle beam control systems require real-time low latency digital feedback with high linearity and dynamic range. Densely packed electronic systems employ high performance multichannel digitizers causing excessive heat dissipation. Therefore, low power dissipation is another critical requirement for these digitizers. A described 12-bit 500 MS/s ADC employs a sub-ranging architecture based on a merged sample & hold circuit, a residue C-DAC and a shared 6-bit flash core ADC. The core ADC provides a sequential coarse and fine digitization featuring a latency of two clock cycles. The ADC is implemented in a 28 nm CMOS process and consumes 4 mW of power per channel from a 0.9 V supply (interfacing and peripheral circuits are excluded). Reduced power consumption and small on-chip area permits the implementation of 32 ADC channels on a 10.7 mm2 chip. The ADC includes a JESD204B standard compliant output data interface operated at the 7.5 Gbps/ch rate. To minimize the data interface related time latency, a special feature permitting to bypass the JESD204B interface is built in. DoE Phase I Award Number: DE-SC0017213.

Simple Exact Algorithm for Transistor Sizing of Low-Power High-Speed Arithmetic Circuits

Directory of Open Access Journals (Sweden)

Tooraj Nikoubin

2010-01-01

Full Text Available A new transistor sizing algorithm, SEA (Simple Exact Algorithm, for optimizing low-power and high-speed arithmetic integrated circuits is proposed. In comparison with other transistor sizing algorithms, simplicity, accuracy, independency of order and initial sizing factors of transistors, and flexibility in choosing the optimization parameters such as power consumption, delay, Power-Delay Product (PDP, chip area or the combination of them are considered as the advantages of this new algorithm. More exhaustive rules of grouping transistors are the main trait of our algorithm. Hence, the SEA algorithm dominates some major transistor sizing metrics such as optimization rate, simulation speed, and reliability. According to approximate comparison of the SEA algorithm with MDE and ADC for a number of conventional full adder circuits, delay and PDP have been improved 55.01% and 57.92% on an average, respectively. By comparing the SEA and Chang's algorithm, 25.64% improvement in PDP and 33.16% improvement in delay have been achieved. All the simulations have been performed with 0.13 m technology based on the BSIM3v3 model using HSpice simulator software.

An 8 bit 1 MS/s SAR ADC with 7.72-ENOB

Science.gov (United States)

Duan, Jihai; Zhu, Zhiyong; Deng, Jinli; Xu, Weilin

2017-08-01

This paper presents a low power 8-bit 1 MS/s SAR ADC with 7.72-bit ENOB. Without an op-amp, an improved segmented capacitor DAC is proposed to reduce the capacitance and the chip area. A dynamic latch comparator with output offset voltage storage technology is used to improve the precision. Adding an extra positive feedback in the latch is to increase the speed. What is more, two pairs of CMOS switches are utilized to eliminate the kickback noise introduced by the latch. The proposed SAR ADC was fabricated in SMIC 0.18 {{μ }}{{m}} CMOS technology. The measured results show that this design achieves an SFDR of 61.8 dB and an ENOB of 7.72 bits, and it consumes 67.5 μW with the FOM of 312 fJ/conversion-step at 1 MS/s sample under 1.8 V power supply. Project supported by the National Natural Science Foundation of China (Nos. 61161003, 61264001, 61166004) and the Guangxi Key Laboratory of Precision Navigation Technology and Application Foundation (No. DH201501).

Design and characterization of a 12-bit 10MS/s 10mW pipelined SAR ADC for CZT-based hard X-ray imager

Science.gov (United States)

Xue, F.; Gao, W.; Duan, Y.; Zheng, R.; Hu, Y.

2018-02-01

This paper presents a 12-bit pipelined successive approximation register (SAR) ADC for CZT-based hard X-ray Imager. The proposed ADC is comprised of a first-stage 6-bit SAR-based Multiplying Digital Analog Converter (MDAC) and a second-stage 8-bit SAR ADC. A novel MDAC architecture using Vcm-based Switching method is employed to maximize the energy efficiency and improve the linearity of the ADC. Moreover, the unit-capacitor array instead of the binary-weighted capacitor array is adopted to improve the conversion speed and linearity of the ADC in the first-stage MDAC. In addition, a new layout design method for the binary-weighted capacitor array is proposed to reduce the capacitor mismatches and make the routing become easier and less-time-consuming. Finally, several radiation-hardened-by-design technologies are adopted in the layout design against space radiation effects. The prototype chip was fabricated in 0.18 μm mixed-signal 1.8V/3.3V process and operated at 1.8 V supply. The chip occupies a core area of only 0.58 mm2. The proposed pipelined SAR ADC achieves a peak signal-to-noise-and-distortion ratio (SNDR) of 66.7 dB and a peak spurious-free dynamic range (SFDR) of 78.6 dB at 10 MS/s sampling rate and consumes 10 mW. The figure of merit (FOM) of the proposed ADC is 0.56 pJ/conversion-step.

A High Speed CMOS Image Sensor with a Novel Digital Correlated Double Sampling and a Differential Difference Amplifier

Directory of Open Access Journals (Sweden)

Daehyeok Kim

2015-03-01

Full Text Available In order to increase the operating speed of a CMOS image sensor (CIS, a new technique of digital correlated double sampling (CDS is described. In general, the fixed pattern noise (FPN of a CIS has been reduced with the subtraction algorithm between the reset signal and pixel signal. This is because a single-slope analog-to-digital converter (ADC has been normally adopted in the conventional digital CDS with the reset ramp and signal ramp. Thus, the operating speed of a digital CDS is much slower than that of an analog CDS. In order to improve the operating speed, we propose a novel digital CDS based on a differential difference amplifier (DDA that compares the reset signal and the pixel signal using only one ramp. The prototype CIS has been fabricated with 0.13 µm CIS technology and it has the VGA resolution of 640 × 480. The measured conversion time is 16 µs, and a high frame rate of 131 fps is achieved at the VGA resolution.

ADC Histogram Analysis of Cervical Cancer Aids Detecting Lymphatic Metastases-a Preliminary Study.

Science.gov (United States)

Schob, Stefan; Meyer, Hans Jonas; Pazaitis, Nikolaos; Schramm, Dominik; Bremicker, Kristina; Exner, Marc; Höhn, Anne Kathrin; Garnov, Nikita; Surov, Alexey

2017-12-01

Apparent diffusion coefficient (ADC) histogram analysis has been used to some extent in cervical cancer (CC) to distinguish between low-grade and high-grade tumors. Although this differentiation is undoubtedly helpful, it would be even more crucial in the presurgical setting to determine whether a tumor already gained the potential to metastasize via the lymphatic system. So far, no studies investigated the potential of 3T ADC histogram analysis in CC to differentiate between nodal-positive and nodal-negative entities. Therefore, the principal aim of our study was to investigate the potential of 3T ADC histogram analysis to differentiate between CC with and without lymph node metastasis. The second aim was to elucidate possible differences in ADC histogram parameters between CC with limited vs. advanced tumor stages and well-differentiated vs. undifferentiated lesions. Finally, correlations of p53 expression and Ki-67 index with ADC parameters were analyzed. Eighteen female patients (mean age 55.4 years, range 32-79 years) with histopathologically confirmed cervical squamous cell carcinoma of the uterine cervix were prospectively enrolled. Tumor stages, tumor grading, status of metastatic dissemination, Ki67-index, and p53 expression were assessed in these patients. Diffusion weighted imaging (DWI) was obtained in a 3T scanner using the following b values: b0 and b1000 s/mm 2 . Group comparisons using Mann-Whitney U test revealed the following findings: nodal-positive CC had statistically significant lower ADC parameters (ADCmin, ADCmean, median ADC, Mode, p10, p25, p75, and p90) in comparison to nodal-negative CC (all p histogram analysis in 3T DWI. This information is crucial for the gynecological surgeon to identify the optimal treatment strategy for patients suffering from CC. Furthermore, ADCentropy was identified as a potential imaging biomarker for tumor heterogeneity and might be able to indicate further molecular changes like loss of p53 expression

High-speed, multi-channel detector readout electronics for fast radiation detectors

International Nuclear Information System (INIS)

Hennig, Wolfgang

2012-01-01

In this project, we are developing a high speed digital spectrometer that a) captures detector waveforms at rates up to 500 MSPS b) has upgraded event data acquisition with additional data buffers for zero dead time operation c) moves energy calculations to the FPGA to increase spectrometer throughput in fast scintillator applications d) uses a streamlined architecture and high speed data interface for even faster readout to the host PC These features are in addition to the standard functions in our existing spectrometers such as digitization, programmable trigger and energy filters, pileup inspection, data acquisition with energy and time stamps, MCA histograms, and run statistics. In Phase I, we upgraded one of our existing spectrometer designs to demonstrate the key principle of fast waveform capture using a 500 MSPS, 12 bit ADC and a Xilinx Virtex-4 FPGA. This upgraded spectrometer, named P500, performed well in initial tests of energy resolution, pulse shape analysis, and timing measurements, thus achieving item (a) above. In Phase II, we are revising the P500 to build a commercial prototype with the improvements listed in items (b)-(d). As described in the previous report, two devices were built to pursue this goal, named the Pixie-500 and the Pixie-500 Express. The Pixie-500 has only minor improvements from the Phase I prototype and is intended as an early commercial product (its production and part of its development were funded outside the SBIR). It also allows testing of the ADC performance in real applications. The Pixie-500 Express (or Pixie-500e) includes all of the improvements (b)-(d). At the end of Phase II of the project, we have tested and debugged the hardware, firmware and software of the Pixie-500 Express prototype boards delivered 12/3/2010. This proved substantially more complex than anticipated. At the time of writing, all hardware bugs have been fixed, the PCI Express interface is working, the SDRAM has been successfully tested and the

High-speed, multi-channel detector readout electronics for fast radiation detectors

Energy Technology Data Exchange (ETDEWEB)

Hennig, Wolfgang

2012-06-22

In this project, we are developing a high speed digital spectrometer that a) captures detector waveforms at rates up to 500 MSPS b) has upgraded event data acquisition with additional data buffers for zero dead time operation c) moves energy calculations to the FPGA to increase spectrometer throughput in fast scintillator applications d) uses a streamlined architecture and high speed data interface for even faster readout to the host PC These features are in addition to the standard functions in our existing spectrometers such as digitization, programmable trigger and energy filters, pileup inspection, data acquisition with energy and time stamps, MCA histograms, and run statistics. In Phase I, we upgraded one of our existing spectrometer designs to demonstrate the key principle of fast waveform capture using a 500 MSPS, 12 bit ADC and a Xilinx Virtex-4 FPGA. This upgraded spectrometer, named P500, performed well in initial tests of energy resolution, pulse shape analysis, and timing measurements, thus achieving item (a) above. In Phase II, we are revising the P500 to build a commercial prototype with the improvements listed in items (b)-(d). As described in the previous report, two devices were built to pursue this goal, named the Pixie-500 and the Pixie-500 Express. The Pixie-500 has only minor improvements from the Phase I prototype and is intended as an early commercial product (its production and part of its development were funded outside the SBIR). It also allows testing of the ADC performance in real applications.The Pixie-500 Express (or Pixie-500e) includes all of the improvements (b)-(d). At the end of Phase II of the project, we have tested and debugged the hardware, firmware and software of the Pixie-500 Express prototype boards delivered 12/3/2010. This proved substantially more complex than anticipated. At the time of writing, all hardware bugs have been fixed, the PCI Express interface is working, the SDRAM has been successfully tested and the SHARC

A low power 12-bit ADC for nuclear instrumentation

International Nuclear Information System (INIS)

Adachi, R.; Landis, D.; Madden, N.; Silver, E.; LeGros, M.

1992-10-01

A low power, successive approximation, analog-to-digital converter (ADC) for low rate, low cost, battery powered applications is described. The ADC is based on a commercial 50 mW successive approximation CMOS device (CS5102). An on-chip self-calibration circuit reduces the inherent differential nonlinearity to 7%. A further reduction of the differential nonlinearity to 0.5% is attained with a four bit Gatti function. The Gatti function is distributed to minimize battery power consumption. All analog functions reside with the ADC while the noisy digital functions reside in the personal computer based histogramming memory. Fiber optic cables carry afl digital information between the ADC and the personal computer based histogramming memory

Comparison of ADC values in different malignancies of the skeletal musculature: a multicentric analysis

International Nuclear Information System (INIS)

Surov, Alexey; Nagata, Shuji; Razek, Ahmed A. Abd; Tirumani, Sree Harsha; Wienke, Andreas; Kahn, Thomas

2015-01-01

range. Muscle sarcomas had a broad range of ADC values. Intramuscular malignant lesions had different ADC values on DWI. 22.8 % of the tumors analyzed had low ADC values, 26.3 % moderate, and 50.9 % high ADC values. Muscle lymphoma had statistically significantly lower ADC values in comparison to muscle metastases and sarcomas. Muscle sarcomas presented with a broad range of ADC values. (orig.)

Comparison of ADC values in different malignancies of the skeletal musculature: a multicentric analysis

Energy Technology Data Exchange (ETDEWEB)

Surov, Alexey [Martin-Luther-University Halle-Wittenberg, Department of Radiology, Halle (Germany); University of Leipzig, Department of Diagnostic and Interventional Radiology, Leipzig (Germany); Nagata, Shuji [Kurume University School of Medicine, Department of Radiology, Kurume (Japan); Razek, Ahmed A. Abd [Mansoura Faculty of Medicine, Department of Diagnostic Radiology, Mansoura (Egypt); Tirumani, Sree Harsha [Harvard Medical School, Department of Imaging, Dana-Farber Cancer Institute and Department of Radiology, Brigham and Women' s Hospital, Boston, MA (United States); Wienke, Andreas [Martin-Luther-University Halle-Wittenberg, Institute of Medical Epidemiology, Biometry, and Statistics, Halle (Germany); Kahn, Thomas [University of Leipzig, Department of Diagnostic and Interventional Radiology, Leipzig (Germany)

2015-04-28

homogeneous with less inter-patient variability and were within a relatively close range. Muscle sarcomas had a broad range of ADC values. Intramuscular malignant lesions had different ADC values on DWI. 22.8 % of the tumors analyzed had low ADC values, 26.3 % moderate, and 50.9 % high ADC values. Muscle lymphoma had statistically significantly lower ADC values in comparison to muscle metastases and sarcomas. Muscle sarcomas presented with a broad range of ADC values. (orig.)

Diagnostic value of ADC in patients with prostate cancer: influence of the choice of b values

International Nuclear Information System (INIS)

Thoermer, Gregor; Otto, Josephin; Reiss-Zimmermann, Martin; Seiwerts, Matthias; Moche, Michael; Garnov, Nikita; Kahn, Thomas; Busse, Harald; Franz, Toni; Do, Minh; Stolzenburg, Jens-Uwe; Horn, Lars-Christian

2012-01-01

To evaluate the influence of the choice of b values on the diagnostic value of the apparent diffusion coefficient (ADC) for detection and grading of prostate cancer (PCa). Forty-one patients with biopsy-proven PCa underwent endorectal 3-T MRI before prostatectomy. Different combinations of b values (0-800 s/mm 2 ) were used to calculate four representative ADC maps. Mean ADCs of tumours and non-malignant tissue were determined. Tumour appearance on different ADC maps was rated by three radiologists as good, fair or poor by assigning a visual score (VS) of 2, 1 or 0, respectively. Differences in the ADC values with the choice of b values were analysed using one-way ANOVA. Choice of b values had a highly (P < 0.001) significant influence on the absolute ADC in each tissue. Maps using b = [50, 800] and [0, 800] were rated best (VS = 1.6 ± 0.3) and second best (1.1 ± 0.3, P < 0.001), respectively. For low-grade carcinomas (Gleason score ≤ 6, 13/41 patients), only the former choice received scores better than fair (VS = 1.4 ± 0.3). Mean tumour ADCs showed significant negative correlation (Spearman's ρ -0.38 to -0.46, P < 0.05) with Gleason score. Absolute ADC values strongly depend on the choice of b values and therefore should be used with caution for diagnostic purposes. A minimum b value greater than zero is recommended for ADC calculation to improve the visual assessment of PCa in ADC maps. (orig.)

Diagnostic value of ADC in patients with prostate cancer: influence of the choice of b values

Energy Technology Data Exchange (ETDEWEB)

Thoermer, Gregor; Otto, Josephin; Reiss-Zimmermann, Martin; Seiwerts, Matthias; Moche, Michael; Garnov, Nikita; Kahn, Thomas; Busse, Harald [Leipzig University Hospital, Department of Diagnostic and Interventional Radiology, Leipzig (Germany); Franz, Toni; Do, Minh; Stolzenburg, Jens-Uwe [Leipzig University Hospital, Department of Urology, Leipzig (Germany); Horn, Lars-Christian [University of Leipzig, Institute of Pathology, Leipzig (Germany)

2012-08-15

To evaluate the influence of the choice of b values on the diagnostic value of the apparent diffusion coefficient (ADC) for detection and grading of prostate cancer (PCa). Forty-one patients with biopsy-proven PCa underwent endorectal 3-T MRI before prostatectomy. Different combinations of b values (0-800 s/mm{sup 2}) were used to calculate four representative ADC maps. Mean ADCs of tumours and non-malignant tissue were determined. Tumour appearance on different ADC maps was rated by three radiologists as good, fair or poor by assigning a visual score (VS) of 2, 1 or 0, respectively. Differences in the ADC values with the choice of b values were analysed using one-way ANOVA. Choice of b values had a highly (P < 0.001) significant influence on the absolute ADC in each tissue. Maps using b = [50, 800] and [0, 800] were rated best (VS = 1.6 {+-} 0.3) and second best (1.1 {+-} 0.3, P < 0.001), respectively. For low-grade carcinomas (Gleason score {<=} 6, 13/41 patients), only the former choice received scores better than fair (VS = 1.4 {+-} 0.3). Mean tumour ADCs showed significant negative correlation (Spearman's {rho} -0.38 to -0.46, P < 0.05) with Gleason score. Absolute ADC values strongly depend on the choice of b values and therefore should be used with caution for diagnostic purposes. A minimum b value greater than zero is recommended for ADC calculation to improve the visual assessment of PCa in ADC maps. (orig.)

A fast ADC scanner for multiparameter nuclear physics experiments

International Nuclear Information System (INIS)

Midttun, G.; Ingebretsen, F.; Holt, K.; Skaali, B.

1983-04-01

A fast readout system for multiparameter experiments in nuclear physics is described. The central part of the CAMAC aquisition hardware is an ADC scanner module. The scanner incorporates a new arbitration logic and direct memory access for simultaneous transfer of singles and correlated data. Together with specially designed ADC interfaces the system can be set up for any configuration of singles and multiparameter events from 1 up to 15 ADC's in one crate

A fast ADC scanner for multiparameter nuclear physics experiments

International Nuclear Information System (INIS)

Midttun, G.; Holt, K.; Ingebretsen, F.; Skaali, B.

1983-01-01

A fast readout system for multiparameter experiments in nuclear physics is described. The central part of the CAMAC aquisition hardware is an ADC scanner module. The scanner incorporates a new arbitration logic and direct memory access for simultaneous transfer of singles and correlated data. Together with specially designed ADC interfaces the system can be set up for any configurations of singles and multiparameter events from 1 up to 15 ADC's in one crate

Role of Arginine decarboxylase (ADC) in Arabidopsis thaliana defence against the pathogenic bacterium Pseudomonas viridiflava.

Science.gov (United States)

Rossi, F R; Marina, M; Pieckenstain, F L

2015-07-01

Polyamine biosynthesis starts with putrescine production through the decarboxylation of arginine or ornithine. In Arabidopsis thaliana, putrescine is synthesised exclusively by arginine decarboxylase (ADC), which exists as two isoforms (ADC1 and 2) that are differentially regulated by abiotic stimuli, but their role in defence against pathogens has not been studied in depth. This work analysed the participation of ADC in Arabidopsis defence against Pseudomonas viridiflava. ADC activity and expression, polyamine levels and bacterial resistance were analysed in null mutants of each ADC isoform. In non-infected wild-type (WT) plants, ADC2 expression was much higher than ADC1. Analysis of adc mutants demonstrated that ADC2 contributes to a much higher extent than ADC1 to basal ADC activity and putrescine biosynthesis. In addition, adc2 mutants showed increased basal expression of salicylic acid- and jasmonic acid-dependent PR genes. Bacterial infection induced putrescine accumulation and ADC1 expression in WT plants, but pathogen-induced putrescine accumulation was blocked in adc1 mutants. Results suggest a specific participation of ADC1 in defence, although basal resistance was not decreased by dysfunction of either of the two ADC genes. In addition, and as opposed to WT plants, bacterial infection increased ADC2 expression and ADC activity in adc1 mutants, which could counterbalance the lack of ADC1. Results demonstrate a major contribution of ADC2 to total ADC activity and the specific induction of ADC1 in response to infection. A certain degree of functional redundancy between the two isoforms in relation to their contribution to basal resistance is also evident. © 2015 German Botanical Society and The Royal Botanical Society of the Netherlands.

Design of eight-channel ADC card for GHz signal conversion

CERN Document Server

Habib, Samer Bou; Jalmuzna, Wojciech; Jezynski, Tomasz

2011-01-01

This paper describes the design of an eight-channel ATCA card suited for direct analog-to-digital conversion of 1.3 GHz signals with a maximum ADC clock frequency of 500 MHz. The undersampling operation is used for signal conversion. This card was designed for the needs of the LLRF system of the FLASH and XFEL accelerators. The designed module consists of a main ATCA board with eight ADCs, FPGA unit, memory, power supply and diagnostic circuits. The main ATCA card allows connecting a daughter board with IPMI, CPU and fast interfaces for communication purposes. This paper describes such issues as system organization allowing acquisition of data at such high data rates, circuit synchronization by high-quality clock signals, CPU and connectivity features, 20-layer PCB design and techniques used for high-frequency signals transmission and matching.

Increased tumour ADC value during chemotherapy predicts improved survival in unresectable pancreatic cancer

Energy Technology Data Exchange (ETDEWEB)

Nishiofuku, Hideyuki; Tanaka, Toshihiro; Kichikawa, Kimihiko [Nara Medical University, Department of Radiology and IVR Center, Kashihara-city, Nara (Japan); Marugami, Nagaaki [Nara Medical University, Department of Endoscopy and Ultrasound, Kashihara-city, Nara (Japan); Sho, Masayuki; Akahori, Takahiro; Nakajima, Yoshiyuki [Nara Medical University, Department of Surgery, Kashihara-city, Nara (Japan)

2016-06-15

To investigate whether changes to the apparent diffusion coefficient (ADC) of primary tumour in the early period after starting chemotherapy can predict progression-free survival (PFS) or overall survival (OS) in patients with unresectable pancreatic adenocarcinoma. Subjects comprised 43 patients with histologically confirmed unresectable pancreatic cancer treated with first-line chemotherapy. Minimum ADC values in primary tumour were measured using the selected area ADC (sADC), which excluded cystic and necrotic areas and vessels, and the whole tumour ADC (wADC), which included whole tumour components. Relative changes in ADC were calculated from baseline to 4 weeks after initiation of chemotherapy. Relationships between ADC and both PFS and OS were modelled by Cox proportional hazards regression. Median PFS and OS were 6.1 and 11.0 months, respectively. In multivariate analysis, sADC change was the strongest predictor of PFS (hazard ratio (HR), 4.5; 95 % confidence interval (CI), 1.7-11.9; p = 0.002). Multivariate Cox regression analysis for OS revealed sADC change and CRP as independent predictive markers, with sADC change as the strongest predictive biomarker (HR, 6.7; 95 % CI, 2.7-16.6; p = 0.001). Relative changes in sADC could provide a useful imaging biomarker to predict PFS and OS with chemotherapy for unresectable pancreatic adenocarcinoma. (orig.)

Volumetric segmentation of ADC maps and utility of standard deviation as measure of tumor heterogeneity in soft tissue tumors.

Science.gov (United States)

Singer, Adam D; Pattany, Pradip M; Fayad, Laura M; Tresley, Jonathan; Subhawong, Ty K

2016-01-01

Determine interobserver concordance of semiautomated three-dimensional volumetric and two-dimensional manual measurements of apparent diffusion coefficient (ADC) values in soft tissue masses (STMs) and explore standard deviation (SD) as a measure of tumor ADC heterogeneity. Concordance correlation coefficients for mean ADC increased with more extensive sampling. Agreement on the SD of tumor ADC values was better for large regions of interest and multislice methods. Correlation between mean and SD ADC was low, suggesting that these parameters are relatively independent. Mean ADC of STMs can be determined by volumetric quantification with high interobserver agreement. STM heterogeneity merits further investigation as a potential imaging biomarker that complements other functional magnetic resonance imaging parameters. Copyright © 2016 Elsevier Inc. All rights reserved.

High resolution ADC interface to main magnet power supply at the NSLS

International Nuclear Information System (INIS)

Bordoley, M.

1993-01-01

Previous readings of DCCT were limited to 11 bits of resolution with large offsets and drifts, providing inaccurate data. The current design overcomes this limitation by using Analog Device's AD7703 20 bit serial output ADC to digitize the main magnet DCCT at the power supply, and transmit the data serially at 2KHz over to the VME controller

Integrating a sampling oscilloscope card and spectroscopy ADCs in a data acquisition system

CERN Document Server

Maartensson, L

2001-01-01

A high-rate sampling oscilloscope card has been integrated into an existing data acquisition system for spectroscopy ADCs. Experiments where pulse-shape analyses are important have then been made possible. Good performance characteristics of the integrated system have been achieved. Spectroscopy ADC data together with pulse-shape data sampled 512 times at 100 MHz are saved to hard disk at event rates up to about 1 kHz with low dead time losses.

Locally advanced rectal cancer: post-chemoradiotherapy ADC histogram analysis for predicting a complete response.

Science.gov (United States)

Cho, Seung Hyun; Kim, Gab Chul; Jang, Yun-Jin; Ryeom, Hunkyu; Kim, Hye Jung; Shin, Kyung-Min; Park, Jun Seok; Choi, Gyu-Seog; Kim, See Hyung

2015-09-01

The value of diffusion-weighted imaging (DWI) for reliable differentiation between pathologic complete response (pCR) and residual tumor is still unclear. Recently, a few studies reported that histogram analysis can be helpful to monitor the therapeutic response in various cancer research. To investigate whether post-chemoradiotherapy (CRT) apparent diffusion coefficient (ADC) histogram analysis can be helpful to predict a pCR in locally advanced rectal cancer (LARC). Fifty patients who underwent preoperative CRT followed by surgery were enrolled in this retrospective study, non-pCR (n = 41) and pCR (n = 9), respectively. ADC histogram analysis encompassing the whole tumor was performed on two post-CRT ADC600 and ADC1000 (b factors 0, 600 vs. 0, 1000 s/mm(2)) maps. Mean, minimum, maximum, SD, mode, 10th, 25th, 50th, 75th, 90th percentile ADCs, skewness, and kurtosis were derived. Diagnostic performance for predicting pCR was evaluated and compared. On both maps, 10th and 25th ADCs showed better diagnostic performance than that using mean ADC. Tenth percentile ADCs revealed the best diagnostic performance on both ADC600 (AZ 0.841, sensitivity 100%, specificity 70.7%) and ADC1000 (AZ 0.821, sensitivity 77.8%, specificity 87.8%) maps. In comparison between 10th percentile and mean ADC, the specificity was significantly improved on both ADC600 (70.7% vs. 53.7%; P = 0.031) and ADC1000 (87.8% vs. 73.2%; P = 0.039) maps. Post-CRT ADC histogram analysis is helpful for predicting pCR in LARC, especially, in improving the specificity, compared with mean ADC. © The Foundation Acta Radiologica 2014.

Performance of CAMAC TDC and ADC in magnetic field

International Nuclear Information System (INIS)

Gupta, S.K.; Barbier, L.M.; Christian, E.R.; Geier, S.; Krizmanic, J.F.; Mitchell, J.W.; Streitmatter, R.E.; Wasilewski, P.J.

1997-01-01

The performance of a LeCroy CAMAC 2228A TDC and a 2249A ADC have been studied in presence of magnetic fields up to 5000 G. The conversion gains of the TDC and ADC increased with magnetic field in a non-linear fashion which can be adequately parameterized by a fourth-order polynomial. The behavior of both the TDC and ADC can be completely understood in terms of a change in the inductance of a ferromagnetic core inductor in the 20 MHz clock circuit of these units. (orig.)

Comparison of performance of analog-to-digital converters (ADC) for pulse height analyzers

International Nuclear Information System (INIS)

Suzuki, Shogo; Hirai, Shoji

1981-01-01

In the recent ADCs for pulse height analyzers (PHA), Wilkinson type is a leading one, and those with 50 to 200 MHz clock frequency and 8K channel are mostly on the market. The comparison of the performance of ADCs was conducted under the condition of using these multi-channel PHAs as γ-ray spectrometers. The following three ADCs were compared: ADC incorporated in CANBERRA 8100 MCA, and CANBERRA 8060 ADCs used as the ADCs for 1st and 2nd GAMA systems. In this case, the conversion gains of these ADCs were set at 4K because the memory of 8100 MCA was 4K, and the GAMA systems were also mostly operated at 4K. In this paper, report is made on the measurements of dead time, the change of γ peaks immediately after the power was turned on, the temperature dependence of ADCs the long term stability of ADCs, derivative non-linearity, and integration non-linearity. The dead time of the ADC of 8100 CMA was shorter in the range up to 1000 channels. The temperature dependence was -0.017%/deg C in 8100 MCA, and -0.061 and -0.072%/deg C in GAMA. The long term stability was -0.02%/14 hr in 8100 MCA, and -0.027%/14 hr in 8060 of 1st GAMA. The derivative non-linearity was 0.45% in 8100 MCA, 0.67% in 8060 of 1st GAMA, and the integration non-linearity was 0.075% for 8100 MCA, and 0.085 - 0.1% in 8060 ADCs. Also, the change of γ peaks immediately after the power was turned on for 8100 ADC was better than that of 8060 ADC. (Wakatsuki, Y.)

High resolution ADC interface to main magnet power supply at the NSLS

Energy Technology Data Exchange (ETDEWEB)

Bordoley, M.

1993-07-01

Previous readings of DCCT were limited to 11 bits of resolution with large offsets and drifts, providing inaccurate data. The current design overcomes this limitation by using Analog Device`s AD7703 20 bit serial output ADC to digitize the main magnet DCCT at the power supply, and transmit the data serially at 2KHz over to the VME controller.

High resolution ADC interface to main magnet power supply at the NSLS

Energy Technology Data Exchange (ETDEWEB)

Bordoley, M.

1993-01-01

Previous readings of DCCT were limited to 11 bits of resolution with large offsets and drifts, providing inaccurate data. The current design overcomes this limitation by using Analog Device's AD7703 20 bit serial output ADC to digitize the main magnet DCCT at the power supply, and transmit the data serially at 2KHz over to the VME controller.

Self-adapted sliding scale spectroscopy ADC

International Nuclear Information System (INIS)

Xu Qichun; Wang Jingjin

1992-01-01

The traditional sliding scale technique causes a disabled range that is equal to the sliding length, thus reduces the analysis range of a MCA. A method for reduce ADC's DNL, which is called self-adapted sliding scale method, has been designed and tested. With this method, the disabled range caused by a traditional sliding scale method can be eliminated by a random trial scale and there is no need of an additional amplitude discriminator with swing threshold. A special trial-and-correct logic is presented. The tested DNL of the spectroscopy ADC described here is less than 0.5%

Can pretreatment ADC values predict recurrence of bladder cancer after transurethral resection?

Energy Technology Data Exchange (ETDEWEB)

Funatsu, Hiroyuki, E-mail: hirofunatsu999@hotmail.com [Division of Diagnostic Imaging, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717 (Japan); Imamura, Akihiro; Takano, Hideyuki [Division of Diagnostic Imaging, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717 (Japan); Ueda, Takeshi [Division of Urology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717 (Japan); Uno, Takashi [Department of Radiology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670 (Japan)

2012-11-15

Objective: The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. Methods: Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver-operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. Results: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08 mm{sup 2}/s vs. 1.28 Multiplication-Sign 10{sup -3} mm{sup 2}/s; p = 0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12 Multiplication-Sign 10{sup -3} mm{sup 2}/s. A modest and significant negative correlation was observed between the ADC values and tumor size (r = -0.436, p = 0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23-32.2, p = 0.027). Conclusion: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.

Can pretreatment ADC values predict recurrence of bladder cancer after transurethral resection?

International Nuclear Information System (INIS)

Funatsu, Hiroyuki; Imamura, Akihiro; Takano, Hideyuki; Ueda, Takeshi; Uno, Takashi

2012-01-01

Objective: The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. Methods: Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver–operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. Results: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08 mm 2 /s vs. 1.28 × 10 −3 mm 2 /s; p = 0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12 × 10 −3 mm 2 /s. A modest and significant negative correlation was observed between the ADC values and tumor size (r = −0.436, p = 0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23–32.2, p = 0.027). Conclusion: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.

Digitally assisted pipeline ADCs theory and implementation

CERN Document Server

Murmann, Boris

2007-01-01

List of Figures. List of Tables. Acknowledgements. Preface. 1: Introduction. 1. Motivation. 2. Overview. 3. Chapter Organization. 2: Performance Trends. 1. Introduction. 2. Digital Performance Trends. 3. ADC Performance Trends. 3: Scaling Analysis. 1. Introduction. 2. Basic Device Scaling from a Digital Perspective. 3. Technology Metrics for Analog Circuits. 4. Scaling Impact on Matching-Limited Circuits. 5. Scaling Impact on Noise-Limited Circuits. 4: Improving Analog Circuit Efficiency. 1. Introduction. 2. Analog Circuit Challenges. 3. The Cost of Feedback. 4. Two-Stage Feedback Amplifier vs. Open-Loop Gain Stage. 5. Discussion. 5: Open-Loop Pipelined ADCs. 1. A Brief Review of Pipelined ADCs. 2. Conventional Stage Implementation. 3. Open-Loop Pipeline Stages. 4. Alternative Transconductor Implementations. 6: Digital Nonlinearity Correction. 1. Overview. 2. Error Model and Digital Correction. 3. Alternative Error Models. 7: Statistics-Based Parameter Estimation. 1. Introduction. 2. Modulation Approach. 3. R...

The use of MRI apparent diffusion coefficient (ADC) in monitoring the development of brain infarction

International Nuclear Information System (INIS)

Shen, Jian-Min; Xia, Xian-Wu; Kang, Wu-Gen; Yuan, Jian-Jun; Sheng, Liang

2011-01-01

To study the rules that apparent diffusion coefficient (ADC) changes with time and space in cerebral infarction, and to provide the evidence in defining the infarction stages. 117 work-ups in 98 patients with cerebral infarction (12 hyperacute, 43 acute, 29 subacute, 10 steady, and 23 chronic infarctions) were imaged with both conventional MRI and diffusion weighted imaging. The average ADC values, the relative ADC (rADC) values, and the ADC values or rADC values from the center to the periphery of the lesion were calculated. The average ADC values and the rADC values of hyperacute and acute infarction lesion depressed obviously. rADC values in hyperacute and acute stage was minimized, and increased progressively as time passed and appeared as 'pseudonormal' values in approximately 8 to 14 days. Thereafter, rADC values became greater than normal in chronic stage. There was positive correlation between rADC values and time (P < 0.01). The ADC values and the rADC values in hyperacute and acute lesions had gradient signs that these lesions increased from the center to the periphery. The ADC values and the rADC values in subacute lesions had adverse gradient signs that these lesions decreased from the center to the periphery. The ADC values of infarction lesions have evolution rules with time and space. The evolution rules with time and those in space can be helpful to decide the clinical stage, and to provide the evidence in guiding the treatment or judging the prognosis in infarction

Photoluminescence detection of alpha particle using DAM-ADC nuclear detector

Energy Technology Data Exchange (ETDEWEB)

Abdalla, Ayman M., E-mail: aymanabdalla62@hotmail.com [Department of Physics, College of Science and Arts, Najran University, P.O. Box 1988, Najran 11001 (Saudi Arabia); Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran 11001 (Saudi Arabia); Harraz, Farid A., E-mail: fharraz68@yahoo.com [Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran 11001 (Saudi Arabia); Nanostructured Materials and Nanotechnology Division, Central Metallurgical Research and Development Institute (CMRDI), P.O. Box: 87 Helwan, Cairo 11421 (Egypt); Ali, Atif M. [Department of Physics, Faculty of Science, King Khalid University, Abha (Saudi Arabia); Al-Sayari, S.A. [Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran 11001 (Saudi Arabia); College of Science and Arts-Sharoura, Najran University (Saudi Arabia); Al-Hajry, A. [Department of Physics, College of Science and Arts, Najran University, P.O. Box 1988, Najran 11001 (Saudi Arabia); Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran 11001 (Saudi Arabia)

2016-09-11

The photoluminescence (PL) and UV–vis spectral analysis of DAM-ADC (diallyl maleate: DAM, polyallyl diglycol carbonate: ADC) nuclear detector are demonstrated for the first time. The DAM-ADC surfaces were exposed to thin {sup 241}Am disk source that emits alpha particles with activity 333 kBq. It is found that the track density of the irradiated samples remarkably influences the PL characteristics of the DAM-ADC detector. The spectral peak heights and the integrated intensities under the peaks exhibit linear correlations with correlation coefficient R{sup 2}=0.9636 and 0.9806, respectively for different alpha particle fluences ranging from 8.16–40.82×10{sup 7} particles/cm{sup 2}. Additionally, a correlation coefficient R{sup 2}=0.9734 was achieved for the UV–vis spectral analysis. The linear fitting functions, along with the corresponding fitting parameters were evaluated in each case. Both the PL and the UV–vis data of the irradiated DAM-ADC samples showed considerable spectral differences, and hence they would be used to offer sensitive approaches for alpha particle detection.

Improved low-distortion sigma-delta ADC with DWA for WLAN standards

Energy Technology Data Exchange (ETDEWEB)

Li Di; Yang Yintang; Zhu Zhangming; Shi Lichun; Wu Xiaofeng; Wang Jiangan, E-mail: lidi2004@126.co [School of Microelectronics, Xidian University, Xi' an 710071 (China)

2010-02-15

An improved low distortion sigma-delta ADC (analog-to-digital converter) for wireless local area network standards is presented. A feed-forward MASH 2-2 multi-bit cascaded sigma-delta ADC is adopted; however, this work shows a much better performance than the ADCs which have been presented to date by adding a feedback factor in the second stage to improve the performance of the in-band SNDR (signal to noise and distortion ratio), using 4-bit ADCs in both stages to minimize the quantization noise. Data weighted averaging technology is therefore used to decrease the mismatch noise induced by the 4-bit DACs, which improves the SFDR (spurious free dynamic range) of the ADC. The modulator has been implemented by a 0.18 {mu}m CMOS process and operates at a single 1.8 V supply voltage. Experimental results show that for a 1.25 MHz - -6 dBFS input signal at 160 MHz sampling frequency, the improved ADC with all non-idealities considered achieves a peak SNDR of 80.9 dB and an SFDR of 87 dB, and the effective number of bits is 13.15 bits. (semiconductor integrated circuits)

The use of MRI apparent diffusion coefficient (ADC in monitoring the development of brain infarction

Directory of Open Access Journals (Sweden)

Yuan Jian-Jun

2011-01-01

Full Text Available Abstract Background To study the rules that apparent diffusion coefficient (ADC changes with time and space in cerebral infarction, and to provide the evidence in defining the infarction stages. Methods 117 work-ups in 98 patients with cerebral infarction (12 hyperacute, 43 acute, 29 subacute, 10 steady, and 23 chronic infarctions were imaged with both conventional MRI and diffusion weighted imaging. The average ADC values, the relative ADC (rADC values, and the ADC values or rADC values from the center to the periphery of the lesion were calculated. Results The average ADC values and the rADC values of hyperacute and acute infarction lesion depressed obviously. rADC values in hyperacute and acute stage was minimized, and increased progressively as time passed and appeared as "pseudonormal" values in approximately 8 to 14 days. Thereafter, rADC values became greater than normal in chronic stage. There was positive correlation between rADC values and time (P Conclusion The ADC values of infarction lesions have evolution rules with time and space. The evolution rules with time and those in space can be helpful to decide the clinical stage, and to provide the evidence in guiding the treatment or judging the prognosis in infarction.

Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage.

Science.gov (United States)

Xu, Kun; Song, Yufeng; Dai, Lianpan; Zhang, Yongli; Lu, Xuancheng; Xie, Yijia; Zhang, Hangjie; Cheng, Tao; Wang, Qihui; Huang, Qingrui; Bi, Yuhai; Liu, William J; Liu, Wenjun; Li, Xiangdong; Qin, Chuan; Shi, Yi; Yan, Jinghua; Zhou, Dongming; Gao, George F

2018-03-15

The recent outbreak of Zika virus (ZIKV) has emerged as a global health concern. ZIKV can persist in human semen and be transmitted by sexual contact, as well as by mosquitoes, as seen for classical arboviruses. We along with others have previously demonstrated that ZIKV infection leads to testis damage and infertility in mouse models. So far, no prophylactics or therapeutics are available; therefore, vaccine development is urgently demanded. Recombinant chimpanzee adenovirus has been explored as the preferred vaccine vector for many pathogens due to the low preexisting immunity against the vector among the human population. Here, we developed a ZIKV vaccine based on recombinant chimpanzee adenovirus type 7 (AdC7) expressing ZIKV M/E glycoproteins. A single vaccination of AdC7-M/E was sufficient to elicit potent neutralizing antibodies and protective immunity against ZIKV in both immunocompetent and immunodeficient mice. Moreover, vaccinated mice rapidly developed neutralizing antibody with high titers within 1 week postvaccination, and the elicited antiserum could cross-neutralize heterologous ZIKV strains. Additionally, ZIKV M- and E-specific T cell responses were robustly induced by AdC7-M/E. Moreover, one-dose inoculation of AdC7-M/E conferred mouse sterilizing immunity to eliminate viremia and viral burden in tissues against ZIKV challenge. Further investigations showed that vaccination with AdC7-M/E completely protected against ZIKV-induced testicular damage. These data demonstrate that AdC7-M/E is highly effective and represents a promising vaccine candidate for ZIKV control. IMPORTANCE Zika virus (ZIKV) is a pathogenic flavivirus that causes severe clinical consequences, including congenital malformations in fetuses and Guillain-Barré syndrome in adults. Vaccine development is a high priority for ZIKV control. In this study, to avoid preexisting anti-vector immunity in humans, a rare serotype chimpanzee adenovirus (AdC7) expressing the ZIKV M

Low Power Continuous-Time Delta-Sigma ADC with Current Output DAC

DEFF Research Database (Denmark)

Marker-Villumsen, Niels; Jørgensen, Ivan Harald Holger; Bruun, Erik

2015-01-01

The paper presents a continuous-time (CT) DeltaSigma (∆Σ) analog-to-digital converter (ADC) using a current output digital-to-analog converter (DAC) for the feedback. From circuit analysis it is shown that using a current output DAC makes it possible to relax the noise requirements of the 1st...... integrator of the loopfilter, and thereby reduce the current consumption. Furthermore, the noise of the current output DAC being dependent on the ADC input signal level, enabling a dynamic range that is larger than the peak signal-to-noise ratio (SNR). The current output DAC is used in a 3rd order multibit...... CT ∆Σ ADC for audio applications, designed in a 0.18 µm CMOS process, with active-RC integrators, a 7-level Flash ADC quantizer and current output DAC for the feedback. From simulations the ADC achieves a dynamic range of 95.0 dB in the audio band, with a current consumption of 284 µA for a 1.7 V...

Extremelly High Bandwidth Rad Hard Data Acquisition System, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Analog-to-digital converters (ADCs) are the key components for digitizing high-speed analog data in modern data acquisition systems, which is a critical part of...

High speed global shutter image sensors for professional applications

Science.gov (United States)

Wu, Xu; Meynants, Guy

2015-04-01

Global shutter imagers expand the use to miscellaneous applications, such as machine vision, 3D imaging, medical imaging, space etc. to eliminate motion artifacts in rolling shutter imagers. A low noise global shutter pixel requires more than one non-light sensitive memory to reduce the read noise. But larger memory area reduces the fill-factor of the pixels. Modern micro-lenses technology can compensate this fill-factor loss. Backside illumination (BSI) is another popular technique to improve the pixel fill-factor. But some pixel architecture may not reach sufficient shutter efficiency with backside illumination. Non-light sensitive memory elements make the fabrication with BSI possible. Machine vision like fast inspection system, medical imaging like 3D medical or scientific applications always ask for high frame rate global shutter image sensors. Thanks to the CMOS technology, fast Analog-to-digital converters (ADCs) can be integrated on chip. Dual correlated double sampling (CDS) on chip ADC with high interface digital data rate reduces the read noise and makes more on-chip operation control. As a result, a global shutter imager with digital interface is a very popular solution for applications with high performance and high frame rate requirements. In this paper we will review the global shutter architectures developed in CMOSIS, discuss their optimization process and compare their performances after fabrication.

Normal cranial bone marrow MR imaging pattern with age-related ADC value distribution

International Nuclear Information System (INIS)

Li Qi; Pan Shinong; Yin Yuming; Li Wei; Chen Zhian; Liu Yunhui; Wu Zhenhua; Guo Qiyong

2011-01-01

Objective: To determine MRI appearances of normal age-related cranial bone marrow and the relationship between MRI patterns and apparent diffusion coefficient (ADC) values. Methods: Five hundred subjects were divided into seven groups based on ages. Cranial bone marrow MRI patterns were performed based on different thickness of the diploe and signal intensity distribution characteristics. ADC values of the frontal, parietal, occipital and temporal bones on DWI were measured and calculated. Correlations between ages and ADC values, between patterns and ADC values, as well as the distribution of ADC values were analyzed. Results: Normal cranial bone marrow was divided into four types and six subtypes, Type I, II, III and IV, which had positive correlation with age increasing (χ 2 = 266.36, P 0.05). In addition, there was significant negative correlation between the ADC values and MRI patterns in the normal parietal and occipital bones (r = -0.691 and -0.750, P < 0.01). Conclusion: The combination of MRI features and ADC values changes in different cranial bones showed significant correlation with age increasing. Familiar with the MRI appearance of the normal bone marrow conversion pattern in different age group and their ADC value will aid the diagnosis and differential of the cranial bone pathology.

Alterations of apparent diffusion coefficient (ADC) in the brain of rats chronically exposed to lead acetate.

Science.gov (United States)

López-Larrubia, Pilar; Cauli, Omar

2011-03-15

Diffusion-weighted imaging (DWI) allows the assessment of the water apparent diffusion coefficient (ADC), a measure of tissue water diffusivity which is altered during different pathological conditions such as cerebral oedema. By means of DWI, we repeatedly measured in the same rats apparent diffusion coefficient ADC in different brain areas (motor cortex (MCx), somato-sensory cortex (SCx), caudate-putamen (CPu), hippocampus (Hip), mesencephalic reticular formation (RF), corpus callosum (CC) and cerebellum (Cb)) after 1 week, 4 and 12 weeks of lead acetate exposure via drinking water (50 or 500 ppm). After 12 weeks of lead exposure rats received albumin-Evans blue complex administration and were sacrificed 1h later. Blood-brain barrier permeability and water tissue content were determined in order to evaluate their relationship with ADC changes. Chronic exposure to lead acetate (500 ppm) for 4 weeks increased ADC values in Hip, RF and Cb but no in other brain areas. After 12 weeks of lead acetate exposure at 500 ppm ADC is significantly increased also in CPu and CC. Brain areas displaying high ADC values after lead exposure showed also an increased water content and increased BBB permeability to Evans blue-albumin complex. Exposure to 50 ppm for 12 weeks increased ADC values and BBB permeability in the RF and Cb. In summary, chronic lead exposure induces cerebral oedema in the adult brain depending on the brain area and the dose of exposure. RF and Cb appeared the most sensitive brain areas whereas cerebral cortex appears resistant to lead-induced cerebral oedema. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

A robust and simple two-mode digital calibration technique for pipelined ADC

Energy Technology Data Exchange (ETDEWEB)

Yin Xiumei; Zhao Nan; Sekedi Bomeh Kobenge; Yang Huazhong, E-mail: yxm@mails.tsinghua.edu.cn [Department of Electronic Engineering, Tsinghua University, Beijing 100084 (China)

2011-03-15

This paper presents a two-mode digital calibration technique for pipelined analog-to-digital converters (ADC). The proposed calibration eliminates the errors of residual difference voltage induced by capacitor mismatch of pseudorandom (PN) sequence injection capacitors at the ADC initialization, while applies digital background calibration to continuously compensate the interstage gain errors in ADC normal operation. The presented technique not only reduces the complexity of analog circuit by eliminating the implementation of PN sequence with accurate amplitude in analog domain, but also improves the performance of digital background calibration by minimizing the sensitivity of calibration accuracy to sub-ADC errors. The use of opamps with low DC gains in normal operation makes the proposed design more compatible with future nanometer CMOS technology. The prototype of a 12-bit 40-MS/s pipelined ADC with the two-mode digital calibration is implemented in 0.18-{mu}m CMOS process. Adopting a simple telescopic opamp with a DC gain of 58-dB in the first stage, the measured SFDR and SNDR within the first Nyquist zone reach 80-dB and 66-dB, respectively. With the calibration, the maximum integral nonlinearity (INL) of the ADC reduces from 4.75-LSB to 0.65-LSB, while the ADC core consumes 82-mW at 3.3-V power supply. (semiconductor integrated circuits)

A mixed signal multi-chip module with high speed serial output links for the ATLAS Level-1 trigger

CERN Document Server

Pfeiffer, U

2000-01-01

We have built and tested a mixed signal multi-chip module (MCM) to be used in the Level-1 Pre-Processor system for the Calorimeter Trigger of the ATLAS experiment at CERN. The MCM performs high speed digital signal processing on four analogue input signals. Results are transmitted serially at a serial data rate of 800 MBd. Nine chips of different technologies are mounted on a four layer Cu substrate. ADC converters and serialiser chips are the major consumers of electrical power on the MCM, which amounts to 9 W for all dies. Special cut-out areas are used to dissipate heat directly to the copper substrate. In this paper we report on design criteria, chosen MCM technology for substrate and die mounting, experiences with the MCM operation and measurement results. (4 refs).

High-speed AC motors

Energy Technology Data Exchange (ETDEWEB)

Jokinen, T.; Arkkio, A. [Helsinki University of Technology Laboratory of Electromechanics, Otaniemi (Finland)

1997-12-31

The paper deals with various types of highspeed electric motors, and their limiting powers. Standard machines with laminated rotors can be utilised if the speed is moderate. The solid rotor construction makes it possible to reach higher power and speed levels than those of laminated rotors. The development work on high-speed motors done at Helsinki University of Technology is presented, too. (orig.) 12 refs.

Histogram analysis derived from apparent diffusion coefficient (ADC) is more sensitive to reflect serological parameters in myositis than conventional ADC analysis.

Science.gov (United States)

Meyer, Hans Jonas; Emmer, Alexander; Kornhuber, Malte; Surov, Alexey

2018-05-01

Diffusion-weighted imaging (DWI) has the potential of being able to reflect histopathology architecture. A novel imaging approach, namely histogram analysis, is used to further characterize tissues on MRI. The aim of this study was to correlate histogram parameters derived from apparent diffusion coefficient (ADC) maps with serological parameters in myositis. 16 patients with autoimmune myositis were included in this retrospective study. DWI was obtained on a 1.5 T scanner by using the b-values of 0 and 1000 s mm - 2 . Histogram analysis was performed as a whole muscle measurement by using a custom-made Matlab-based application. The following ADC histogram parameters were estimated: ADCmean, ADCmax, ADCmin, ADCmedian, ADCmode, and the following percentiles ADCp10, ADCp25, ADCp75, ADCp90, as well histogram parameters kurtosis, skewness, and entropy. In all patients, the blood sample was acquired within 3 days to the MRI. The following serological parameters were estimated: alanine aminotransferase, aspartate aminotransferase, creatine kinase, lactate dehydrogenase, C-reactive protein (CRP) and myoglobin. All patients were screened for Jo1-autobodies. Kurtosis correlated inversely with CRP (p = -0.55 and 0.03). Furthermore, ADCp10 and ADCp90 values tended to correlate with creatine kinase (p = -0.43, 0.11, and p = -0.42, = 0.12 respectively). In addition, ADCmean, p10, p25, median, mode, and entropy were different between Jo1-positive and Jo1-negative patients. ADC histogram parameters are sensitive for detection of muscle alterations in myositis patients. Advances in knowledge: This study identified that kurtosis derived from ADC maps is associated with CRP in myositis patients. Furthermore, several ADC histogram parameters are statistically different between Jo1-positive and Jo1-negative patients.

A 12-bit 40 MS/s pipelined ADC with over 80 dB SFDR

Energy Technology Data Exchange (ETDEWEB)

Wei Qi; Yin Xiumei; Han Dandan; Yang Huazhong, E-mail: q-wei05@mails.tsinghua.edu.c [Department of Electronic Engineering, Tsinghua University, Beijing 100084 (China)

2010-02-15

This paper describes a 12-bit 40 MS/s calibration-free pipelined analog-to-digital converter (ADC), which is optimized for high spurious free dynamic range (SFDR) performance and low power dissipation. With a 4.9 MHz sine wave input, the prototype ADC implemented in a 0.18-{mu}m 1P6M CMOS process shows measured differential nonlinearity and integral nonlinearity within 0.78 and 1.32 least significant bits at the 12-bit level without any trimming or calibration. The ADC, with a total die area of 3.1 x 2.1 mm{sup 2}, demonstrates a maximum signal-to-noise distortion ratio (SNDR) and SFDR of 66.32 and 83.38 dB, respectively, at a 4.9 MHz analog input and a power consumption of 102 mW from a 1.8 V supply. (semiconductor integrated circuits)

PI-RADS v2 and ADC values: is there room for improvement?

Science.gov (United States)

Jordan, Eric J; Fiske, Charles; Zagoria, Ronald; Westphalen, Antonio C

2018-03-17

To determine the diagnostic accuracy of ADC values in combination with PI-RADS v2 for the diagnosis of clinically significant prostate cancer (CS-PCa) compared to PI-RADS v2 alone. This retrospective study included 155 men whom underwent 3-Tesla prostate MRI and subsequent MR/US fusion biopsies at a single non-academic center from 11/2014 to 3/2016. All scans were performed with a surface coil and included T2, diffusion-weighted, and dynamic contrast-enhanced sequences. Suspicious findings were classified using Prostate Imaging Reporting and Data System (PI-RADS) v2 and targeted using MR/US fusion biopsies. Mixed-effect logistic regression analyses were used to determine the ability of PIRADS v2 alone and combined with ADC values to predict CS-PCa. As ADC categories are more practical in clinical situations than numeric values, an additional model with ADC categories of ≤ 800 and > 800 was performed. A total of 243 suspicious lesions were included, 69 of which were CS-PCa, 34 were Gleason score 3+3 PCa, and 140 were negative. The overall PIRADS v2 score, ADC values, and ADC categories are independent statistically significant predictors of CS-PCa (p values or categories is better discrimination of PI-RADS v2 4 lesions. ADC values and categories help to diagnose CS-PCa when lesions are assigned a PI-RADS v2 score of 4.

An Optimization-Based Reconfigurable Design for a 6-Bit 11-MHz Parallel Pipeline ADC with Double-Sampling S&H

Directory of Open Access Journals (Sweden)

Wilmar Carvajal

2012-01-01

Full Text Available This paper presents a 6 bit, 11 MS/s time-interleaved pipeline A/D converter design. The specification process, from block level to elementary circuits, is gradually covered to draw a design methodology. Both power consumption and mismatch between the parallel chain elements are intended to be reduced by using some techniques such as double and bottom-plate sampling, fully differential circuits, RSD digital correction, and geometric programming (GP optimization of the elementary analog circuits (OTAs and comparators design. Prelayout simulations of the complete ADC are presented to characterize the designed converter, which consumes 12 mW while sampling a 500 kHz input signal. Moreover, the block inside the ADC with the most stringent requirements in power, speed, and precision was sent to fabrication in a CMOS 0.35 μm AMS technology, and some postlayout results are shown.

Regional ADC values of the normal brain: differences due to age, gender, and laterality.

Science.gov (United States)

Naganawa, Shinji; Sato, Kimihide; Katagiri, Toshio; Mimura, Takeo; Ishigaki, Takeo

2003-01-01

The purpose of this study was to evaluate the stability of measurement for apparent diffusion coefficient (ADC) values in normal brain, to clarify the effect of aging on ADC values, to compare ADC values between men and women, and to compare ADC values between right and left sides of the brain. To evaluate the stability of measurements, five normal volunteers (four men and one woman) were examined five times on different days. Then, 294 subjects with normal MR imaging (147 men and 147 women; age range 20-89 years) were measured. The ADC measurement in normal volunteers was stable. The ADC values stayed within the 5% deviation of average values in all volunteers (mean+/-standard deviation 2.3+/-1.2%). The ADC values gradually increased by aging in all regions. In thalamus, no significant difference was seen between right and left in the subjects under 60 years; however, right side showed higher values in the subjects over 60 years (pright frontal, bilateral thalamus, and temporal (pbrain and may be useful for the future quantitative study as a reference.

Design and development of CAMAC 12 bit ADC/DAC dual purpose module

International Nuclear Information System (INIS)

Kulkarni, S.G.; Gore, J.A.; Ramlal, V.; Matkar, U.V.; Lokare, R.N.; Yadav, M.L.; Ekambaram, M.; Gupta, A.K.; Datar, V.M.

2013-01-01

A dual function CAMAC module is designed for Pelletron Accelerator which can function as 12 bit 8 channels DAC or 12 bit 16 channels ADC. Spartan 2 series of FPGA is used for implementing the CAMAC interface logic as well as logic for ADC/DAC interface. The PCB has both the ADC and DAC mounted but the module can have only one function selected due to wiring constraint. Two different VHDL programs (one for the ADC and other for the DAC) reside on the EEPROM permitting selection of any one as per the functionality required. The module is working as a 12 bit DAC at BARC-TIFR Pelletron Linac Facility, successfully. (author)

55-mW, 1.2-V, 12-bit, 100-MSPS Pipeline ADCs for Wireless Receivers

Science.gov (United States)

Ito, Tomohiko; Kurose, Daisuke; Ueno, Takeshi; Yamaji, Takafumi; Itakura, Tetsuro

For wireless receivers, low-power 1.2-V 12-bit 100-MSPS pipeline ADCs are fabricated in 90-nm CMOS technology. To achieve low-power dissipation at 1.2V without the degradation of SNR, the configuration of 2.5bit/stage is employed with an I/Q amplifier sharing technique. Furthermore, single-stage pseudo-differential amplifiers are used in a Sample-and-Hold (S/H) circuit and a 1st Multiplying Digital-to-Analog Converter (MDAC). The pseudo-differential amplifier with two-gain-stage transimpedance gain-boosting amplifiers realizes high DC gain of more than 90dB with low power. The measured SNR of the 100-MSPS ADC is 66.7dB at 1.2-V supply. Under that condition, each ADC dissipates only 55mW.

Changes in ADC Caused by Tensile Loading of Rabbit Achilles Tendon: Evidence for Water Transport

Science.gov (United States)

Han, S.; Gemmell, S. J.; Helmer, K. G.; Grigg, P.; Wellen, J. W.; Hoffman, A. H.; Sotak, C. H.

2000-06-01

Water diffusion measurements were performed on rabbit Achilles tendons during static tensile loading and tendons in an unloaded state. The apparent diffusion coefficient (ADC) was measured along two directions: parallel and perpendicular to the long axis of the tendon. Tendons were studied after being prepared in two ways: (a) after being stored frozen in phosphate-buffered saline (PBS) and (b) freshly isolated. Statistically significant directional anisotropy was observed in the ADC in all tendons. The ADC was significantly greater in the direction parallel to the long axis of the tendon than in the perpendicular direction. The anisotropy is attributed to the greater restrictions seen by the water molecules in the perpendicular direction and is consistent with the known geometry of the tendon. Storage in PBS caused tendons to swell. This increased the ADC measured along both directions and reduced the anisotropy. The existence of anisotropy in the ADC was not related to the orientation of the specimen in the magnet. The ADC increased along both directions following the application of a 5-N tensile load; the increase was greatest along the perpendicular axis of the tendon. In order to determine whether load-related changes in the ADC reflected changes in interfibrilar spacing, we used electron microscopy to measure load-related changes in fibril spacing. Load-related changes in fiber spacing could not account for the observed changes in the ADC. The increase in ADC caused by loading was attributed to the extrusion of tendon water into a bulk phase along the outside surface of the tendon. In PBS-stored samples, enough fluid was extruded that it could be visualized. The transient response of the ADC to a 5-N tensile load was also studied. The absolute ADC in both directions increased with loading and recovered to baseline upon unloading. The transient changes in ADC, for both loading and unloading, had a mean time constant of approximately 15 min. The magnitude of

Pseudo Asynchronous Level Crossing adc for ecg Signal Acquisition.

Science.gov (United States)

Marisa, T; Niederhauser, T; Haeberlin, A; Wildhaber, R A; Vogel, R; Goette, J; Jacomet, M

2017-02-07

A new pseudo asynchronous level crossing analogue-to-digital converter (adc) architecture targeted for low-power, implantable, long-term biomedical sensing applications is presented. In contrast to most of the existing asynchronous level crossing adc designs, the proposed design has no digital-to-analogue converter (dac) and no continuous time comparators. Instead, the proposed architecture uses an analogue memory cell and dynamic comparators. The architecture retains the signal activity dependent sampling operation by generating events only when the input signal is changing. The architecture offers the advantages of smaller chip area, energy saving and fewer analogue system components. Beside lower energy consumption the use of dynamic comparators results in a more robust performance in noise conditions. Moreover, dynamic comparators make interfacing the asynchronous level crossing system to synchronous processing blocks simpler. The proposed adc was implemented in [Formula: see text] complementary metal-oxide-semiconductor (cmos) technology, the hardware occupies a chip area of 0.0372 mm 2 and operates from a supply voltage of [Formula: see text] to [Formula: see text]. The adc's power consumption is as low as 0.6 μW with signal bandwidth from [Formula: see text] to [Formula: see text] and achieves an equivalent number of bits (enob) of up to 8 bits.

High speed heterostructure devices

CERN Document Server

Beer, Albert C; Willardson, R K; Kiehl, Richard A; Sollner, T C L Gerhard

1994-01-01

Volume 41 includes an in-depth review of the most important, high-speed switches made with heterojunction technology. This volume is aimed at the graduate student or working researcher who needs a broad overview andan introduction to current literature. Key Features * The first complete review of InP-based HFETs and complementary HFETs, which promise very low power and high speed * Offers a complete, three-chapter review of resonant tunneling * Provides an emphasis on circuits as well as devices.

Value of apparent diffusion coefficient (ADC) in assessing radiotherapy and chemotherapy success in cervical cancer.

Science.gov (United States)

Fu, Zhan-Zhao; Peng, Yong; Cao, Li-Yan; Chen, Yan-Sheng; Li, Kun; Fu, Bao-Hong

2015-06-01

We investigated the clinical significance of apparent diffusion coefficient (ADC) values in diffusion-weighted magnetic resonance imaging (DWI) in monitoring the efficacy of radiotherapy (RT) and chemotherapy (CT) treatments in cervical cancer. In order to identify relevant high quality clinical cohort studies reporting the use of DWI in cervical cancers, the following electronic databases in English and Chinese languages were comprehensively searched: MEDLINE, Science Citation Index database, Cochrane Library Database, PubMed, Embase, CINAHL, and Current Contents Index; Chinese Biomedical Database, Chinese Journal Full-Text Database. All selected studies were published prior to March 2014, and data extracted from these studies were analyzed using STATA 12.0 statistical software. We initially retrieved 196 articles (79 Chinese articles and 117 English articles) through database searches and finally selected sixteen cohort studies for this meta-analysis. The 16 studies contained a combined total of 517 subjects, and all selected studies reported the mean ADC value (10(-3) mm(2)/s) in DWI in cervical cancer patients treated with RT and CT. Combined standardized mean difference (SMD) suggested that the mean post-RT and mean post-CT ADC values were significantly higher than the mean pre-RT and mean pre-CT ADC values, respectively, in cervical cancer patients (SMD=2.95, 95% CI=2.19-3.72, P900 (SMD=2.55, 95% CI=1.78-3.32, P<0.001). The mean ADC value in patients without residual tumor post-RT and post-CT treatment was significantly higher than seen in patients with residual tumors (SMD=0.80, 95% CI=0.49-1.12, P<0.001). Our meta-analysis revealed a significant correlation between mean ADC values and the clinical response to RT and CT treatment. Thus, ADC values in DWI may be effective in evaluating the clinical outcome of treatments in cervical cancer patients. Copyright © 2015 Elsevier Inc. All rights reserved.

Sensorless Speed Control of Permanent Magnet Synchronous Motors by Neural Network Algorithm

Directory of Open Access Journals (Sweden)

Ming-Shyan Wang

2014-01-01

Full Text Available The sliding mode control has the merits with respect to the variation of the disturbance and robustness. In this paper, the sensorless sliding-mode observer with least mean squared error approach for permanent magnet synchronous motor (PMSM to detect the rotor position by counter electromotive force and then compute motor speed is designed and implemented. In addition, the neural network control is also used to compensate the PI gain tuning to increase the speed accuracy without regarding the errors of the current measurement and motor noise. In this paper, a digital signal processor TMS320F2812 utilizes its high-speed ADC module to get current feedback information and thus to estimate the rotor position and takes advantage of the built-in modules to achieve SVPWM current control so that the senseless speed control will be accomplished. The correctness and effectiveness of the proposed control system will be verified from the experimental results.

Diffusion-weighted (DW) MRI in lung cancers. ADC test-retest repeatability

Energy Technology Data Exchange (ETDEWEB)

Weller, Alex; Papoutsaki, Marianthi Vasiliki; Blackledge, Matthew; DeSouza, Nandita M. [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK Cancer Imaging Centre, Surrey (United Kingdom); Waterton, John C. [University of Manchester, Manchester (United Kingdom); Chiti, Arturo [Humanitas University, Milan (Italy); Stroobants, Sigrid [Universiteit Antwerpen, Antwerpen (Belgium); Kuijer, Joost [Vrije Universiteit Medisch Centrum, Amsterdam (Netherlands); Morgan, Veronica [Royal Marsden NHS Foundation Trust, Department of Medicine, London (United Kingdom)

2017-11-15

To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision. Thirty malignant lung lesions >2 cm in size (23 patients) were scanned on two occasions, using echo-planar-Diffusion-Weighted (DW)-MRI to derive whole-tumour ADC (b = 100, 500 and 800 s/mm{sup -2}). Scanning was performed at 4 institutions (3 MRI vendors). Whole-tumour volumes-of-interest were copied from first visit onto second visit images and from one post-processing platform to an open-source platform, to assess ADC repeatability and cross-platform reproducibility. Whole-tumour ADC values ranged from 0.66-1.94x10{sup -3} mm{sup 2}s{sup -1} (mean = 1.14). Within-patient coefficient-of-variation (wCV) was 7.1% (95% CI 5.7-9.6%), limits-of-agreement (LoA) -18.0 to 21.9%. Lesions >3 cm had improved repeatability: wCV 3.9% (95% CI 2.9-5.9%); and LoA -10.2 to 11.4%. Variability for lesions <3 cm was 2.46 times higher. ADC reproducibility across different post-processing platforms was excellent: Pearson's R{sup 2} = 0.99; CoV 2.8% (95% CI 2.3-3.4%); and LoA -7.4 to 8.0%. A free-breathing DW-MRI protocol for imaging malignant lung tumours achieved satisfactory within-patient repeatability and was robust to changes in post-processing software, justifying its use in multi-centre trials. For response evaluation in individual patients, a change in ADC >21.9% will reflect treatment-related change. (orig.)

Diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient (ADC) determination in normal and pathological fetal kidneys.

Science.gov (United States)

Chaumoitre, K; Colavolpe, N; Shojai, R; Sarran, A; D' Ercole, C; Panuel, M

2007-01-01

To assess the use of diffusion-weighted magnetic resonance imaging (DW-MRI) in the evaluation of the fetal kidney and to estimate age-dependent changes in the apparent diffusion coefficient (ADC) of normal and pathological fetal kidneys. DW-MRI was performed on a 1.5-T machine at 23-38 gestational weeks in 51 pregnant women in whom the fetal kidneys were normal and in 10 whose fetuses had renal pathology (three with suspected nephropathy, three with renal tract dilatation, one with unilateral renal venous thrombosis, and three with twin-twin transfusion syndrome (TTTS)). The ADC was measured in an approximately 1-cm2 region of interest within the renal parenchyma. ADC values in normal renal parenchyma ranged from 1.1 to 1.8 10(-3) mm2 s-1. There was no significant age-dependent change in the ADC of normal kidneys. In cases of nephropathy, the ADC value was not always pathological but an ADC map could show abnormal findings. In cases of dilatation, the ADC value was difficult to determine when the dilatation was huge. In cases of TTTS, the ADC of the donor twin was higher than that of the recipient twin and the difference seemed to be related to the severity of the syndrome. Evaluation of the ADC for fetal kidneys is feasible. Fetal measurement of the ADC value and ADC maps may be useful tools with which to explore the fetal kidney when used in conjunction with current methods. DW-MR images, ADC value and ADC map seem to be useful in cases of suspected nephropathy (hyperechoic kidneys), dilated kidney and vascular pathology (renal venous thrombosis, TTTS). Copyright (c) 2006 ISUOG.

Implementation of integrated circuit and design of SAR ADC for fully implantable hearing aids.

Science.gov (United States)

Kim, Jong Hoon; Lee, Jyung Hyun; Cho, Jin-Ho

2017-07-20

The hearing impaired population has been increasing; many people suffer from hearing problems. To deal with this difficulty, various types of hearing aids are being rapidly developed. In particular, fully implantable hearing aids are being actively studied to improve the performance of existing hearing aids and to reduce the stigma of hearing loss patients. It has to be of small size and low-power consumption for easy implantation and long-term use. The objective of the study was to implement a small size and low-power consumption successive approximation register analog-to-digital converter (SAR ADC) for fully implantable hearing aids. The ADC was selected as the SAR ADC because its analog circuit components are less required by the feedback circuit of the SAR ADC than the sigma-delta ADC which is conventionally used in hearing aids, and it has advantages in the area and power consumption. So, the circuit of SAR ADC is designed considering the speech region of humans because the objective is to deliver the speech signals of humans to hearing loss patients. If the switch of sample and hold works in the on/off positions, the charge injection and clock feedthrough are produced by a parasitic capacitor. These problems affect the linearity of the hold voltage, and as a result, an error of the bit conversion is generated. In order to solve the problem, a CMOS switch that consists of NMOS and PMOS was used, and it reduces the charge injection because the charge carriers in the NMOS and PMOS have inversed polarity. So, 16 bit conversion is performed before the occurrence of the Least Significant Bit (LSB) error. In order to minimize the offset voltage and power consumption of the designed comparator, we designed a preamplifier with current mirror. Therefore, the power consumption was reduced by the power control switch used in the comparator. The layout of the designed SAR ADC was performed by Virtuoso Layout Editor (Cadence, USA). In the layout result, the size of the

The Adc/Lmb System Mediates Zinc Acquisition in Streptococcus agalactiae and Contributes to Bacterial Growth and Survival.

Science.gov (United States)

Moulin, Pauline; Patron, Kévin; Cano, Camille; Zorgani, Mohamed Amine; Camiade, Emilie; Borezée-Durant, Elise; Rosenau, Agnès; Mereghetti, Laurent; Hiron, Aurélia

2016-12-15

The Lmb protein of Streptococcus agalactiae is described as an adhesin that binds laminin, a component of the human extracellular matrix. In this study, we revealed a new role for this protein in zinc uptake. We also identified two Lmb homologs, AdcA and AdcAII, redundant binding proteins that combine with the AdcCB translocon to form a zinc-ABC transporter. Expression of this transporter is controlled by the zinc concentration in the medium through the zinc-dependent regulator AdcR. Triple deletion of lmb, adcA, and adcAII, or that of the adcCB genes, impaired growth and cell separation in a zinc-restricted environment. Moreover, we found that this Adc zinc-ABC transporter promotes S. agalactiae growth and survival in some human biological fluids, suggesting that it contributes to the infection process. These results indicated that zinc has biologically vital functions in S. agalactiae and that, under the conditions tested, the Adc/Lmb transporter constitutes the main zinc acquisition system of the bacterium. A zinc transporter, composed of three redundant binding proteins (Lmb, AdcA, and AdcAII), was characterized in Streptococcus agalactiae This system was shown to be essential for bacterial growth and morphology in zinc-restricted environments, including human biological fluids. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

14 CFR 23.253 - High speed characteristics.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false High speed characteristics. 23.253 Section... Requirements § 23.253 High speed characteristics. If a maximum operating speed VMO/MMO is established under § 23.1505(c), the following speed increase and recovery characteristics must be met: (a) Operating...

Predicting Treatment Response of Colorectal Cancer Liver Metastases to Conventional Lipiodol-Based Transarterial Chemoembolization Using Diffusion-Weighted MR Imaging: Value of Pretreatment Apparent Diffusion Coefficients (ADC) and ADC Changes Under Therapy.

Science.gov (United States)

Lahrsow, Maximilian; Albrecht, Moritz H; Bickford, Matthew W; Vogl, Thomas J

2017-06-01

To use absolute pretreatment apparent diffusion coefficients (ADC) derived from diffusion-weighted MR imaging (DWI) to predict response to repetitive cTACE for unresectable liver metastases of colorectal carcinoma (CRLM) at 1 and 3 months after start of treatment. Fifty-five metastases in 34 patients were examined with DWI prior to treatment and 1 month after initial cTACE. Treatment was performed in 4-week intervals. Response was evaluated at 1 and 3 months after start of therapy. Metastases showing a decrease of ≥30% in axial diameter were classified as responding lesions. One month after initial cTACE, seven lesions showed early response. There was no significant difference in absolute pretreatment ADC values between responding and non-responding lesions (p = 0.94). Three months after initial cTACE, 17 metastases showed response. There was a significant difference (p = 0.021) between absolute pretreatment ADC values of lesions showing response (median 1.08 × 10 -3  mm 2 /s) and no response (median 1.30 × 10 -3  mm 2 /s). Pretreatment ADC showed fair diagnostic value to predict response (AUC 0.7). Lesions showing response at 3 months also revealed a significant increase in ADC between measurements before treatment and at one month after initial cTACE (p < 0.001). Applying an increase in ADC of 12.17%, response at 3 months after initial cTACE could be predicted with a sensitivity and specificity of 77 and 74%, respectively (AUC 0.817). Furthermore, there was a strong and significant correlation (r = 0.651, p < 0.001) between percentage change in size after third cTACE and percentage change in ADC. In patients with CRLM, ADC measurements are potential biomarkers for assessing response to cTACE.

The changes of 18F-FDG uptake and ADC value of the normal endometrium during the menstrual cycle

International Nuclear Information System (INIS)

Seko, Ayumi; Kanasaki, Shuzou; Kitahara, Sawako; Murata, Kiyoshi; Tatsumi, Mitsuaki; Hayashida, Kohei; Sakashita, Yoko; Hamanaka, Yasuyo

2007-01-01

We evaluated the normal endometrium of reproductive age using positron emission tomography (PET)/CT and Diffusion-weighted MR imaging. 18 F-fluorodeoxyglucose (FDG) uptake and apparent diffusion coefficient (ADC) value were classified according to the menstrual cycle. On PET/CT, FDG uptake was significant high at the menstrual and ovulatory phase. On diffusion-weighted imaging (DWI), ADC value was significant low at the menstrual phase. (author)

Assessment and quantification of sources of variability in breast apparent diffusion coefficient (ADC) measurements at diffusion weighted imaging

International Nuclear Information System (INIS)

Giannotti, E.; Waugh, S.; Priba, L.; Davis, Z.; Crowe, E.; Vinnicombe, S.

2015-01-01

Highlights: • Inter-scan errors have minimal contribution to ADC measurement variability. • Intra-observer measures of ADC values in breast cancer are excellent. • ADC measures in whole tumour are more reproducible than minimum ADC measures. • ADC measurement error is most influenced by multiple readers. - Abstract: Purpose: Apparent Diffusion Coefficient (ADC) measurements are increasingly used for assessing breast cancer response to neoadjuvant chemotherapy although little data exists on ADC measurement reproducibility. The purpose of this work was to investigate and characterise the magnitude of errors in ADC measures that may be encountered in such follow-up studies- namely scanner stability, scan–scan reproducibility, inter- and intra- observer measures and the most reproducible measurement of ADC. Methods: Institutional Review Board approval was obtained for the prospective study of healthy volunteers and written consent acquired for the retrospective study of patient images. All scanning was performed on a 3.0-T MRI scanner. Scanner stability was assessed using an ice-water phantom weekly for 12 weeks. Inter-scan repeatability was assessed across two scans of 10 healthy volunteers (26–61 years; mean: 44.7 years). Inter- and intra-reader analysis repeatability was measured in 52 carcinomas from clinical patients (29–70 years; mean: 50.0 years) by measuring the whole tumor ADC value on a single slice with maximum tumor diameter (ADC S ) and the ADC value of a small region of interest (ROI) on the same slice (ADC min ). Repeatability was assessed using intraclass correlation coefficients (ICC) and coefficients of repeatability (CoR). Results: Scanner stability contributed 6% error to phantom ADC measurements (0.071 × 10 −3 mm 2 /s; mean ADC = 1.089 × 10 −3 mm 2 /s). The measured scan-scan CoR in the volunteers was 0.122 × 10 −3 mm 2 /s, contributing an error of 8% to the mean measured values (ADC scan1 = 1.529 × 10 −3 mm 2 /s; ADC scan

Discrimination between intact and decayed pulp regions in carious teeth by ADC mapping.

Science.gov (United States)

Cankar, Ksenija; Nemeth, Lidija; Bajd, Franci; Vidmar, Jernej; Serša, Igor

2014-01-01

The aim of this study was to evaluate an advanced magnetic resonance imaging (MRI) method, apparent diffusion coefficient (ADC) mapping, in the functional assessment of carious teeth. 38 extracted human teeth with scores of 0, 3 and 6 according to International Caries Detection and Assessment System (ICDAS) criteria were screened and subsequently analyzed by MRI at 2.35 T. Histology sectioning of teeth was used for the gold standard by analyzing two extreme cases (intact and severely decayed). ADC maps of the same teeth were calculated from corresponding diffusion-weighted images and used to obtain ADC distributions along dental pulp as functions of the relative pulp length measured from the occlusal pulp side. The measured distributions were analyzed for the best fit by a four-parameter three-segment linear regression model for ADC distribution along the pulp. MRI results were in good agreement with findings in histological sections of identical teeth. The best fit model parameters, relative decayed region depth, relative transition region width and ADC values of intact and decayed pulp tissue, showed statistically significant differences between the ADC values of intact and decayed pulp tissue (1.0 × 10(-9) m(2)/s vs. 0.74-0.89 × 10(-9) m(2)/s) and the relative decayed region depth progressing with ICDAS score (3 vs. 46% with ICDAS 3 vs. ICDAS 6). The results of this feasibility study confirmed relevance of ADC mapping for the discrimination and localization of intact and decayed regions in dental pulps of carious teeth. © 2014 S. Karger AG, Basel.

Regional ADC values of the normal brain: differences due to age, gender, and laterality

Energy Technology Data Exchange (ETDEWEB)

Naganawa, Shinji; Ishigaki, Takeo [Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya 466-8550 (Japan); Sato, Kimihide; Katagiri, Toshio; Mimura, Takeo [Department of Radiology, First Kamiida General Hospital (Japan)

2003-01-01

The purpose of this study was to evaluate the stability of measurement for apparent diffusion coefficient (ADC) values in normal brain, to clarify the effect of aging on ADC values, to compare ADC values between men and women, and to compare ADC values between right and left sides of the brain. To evaluate the stability of measurements, five normal volunteers (four men and one woman) were examined five times on different days. Then, 294 subjects with normal MR imaging (147 men and 147 women; age range 20-89 years) were measured. The ADC measurement in normal volunteers was stable. The ADC values stayed within the 5% deviation of average values in all volunteers (mean{+-}standard deviation 2.3{+-}1.2%). The ADC values gradually increased by aging in all regions. In thalamus, no significant difference was seen between right and left in the subjects under 60 years; however, right side showed higher values in the subjects over 60 years (p<0.01). In the subjects under 60 years, women showed higher values in right frontal, bilateral thalamus, and temporal (p<0.01); however, in the subjects over 60 years, no region showed difference between men and women. The knowledge obtained in this study may be helpful to understand the developmental and aging mechanisms of normal brain and may be useful for the future quantitative study as a reference. (orig.)

Regional ADC values of the normal brain: differences due to age, gender, and laterality

International Nuclear Information System (INIS)

Naganawa, Shinji; Ishigaki, Takeo; Sato, Kimihide; Katagiri, Toshio; Mimura, Takeo

2003-01-01

The purpose of this study was to evaluate the stability of measurement for apparent diffusion coefficient (ADC) values in normal brain, to clarify the effect of aging on ADC values, to compare ADC values between men and women, and to compare ADC values between right and left sides of the brain. To evaluate the stability of measurements, five normal volunteers (four men and one woman) were examined five times on different days. Then, 294 subjects with normal MR imaging (147 men and 147 women; age range 20-89 years) were measured. The ADC measurement in normal volunteers was stable. The ADC values stayed within the 5% deviation of average values in all volunteers (mean±standard deviation 2.3±1.2%). The ADC values gradually increased by aging in all regions. In thalamus, no significant difference was seen between right and left in the subjects under 60 years; however, right side showed higher values in the subjects over 60 years (p<0.01). In the subjects under 60 years, women showed higher values in right frontal, bilateral thalamus, and temporal (p<0.01); however, in the subjects over 60 years, no region showed difference between men and women. The knowledge obtained in this study may be helpful to understand the developmental and aging mechanisms of normal brain and may be useful for the future quantitative study as a reference. (orig.)

Diffusion-weighted MRI in prostatic lesions: Diagnostic performance of normalized ADC using normal peripheral prostatic zone as a reference

Directory of Open Access Journals (Sweden)

Tamer F. Taha Ali

2018-03-01

Full Text Available Aim of study: Evaluate the potential value of the normal peripheral zone as a reference organ to normalize prostatic lesion apparent diffusion coefficient (ADC to improve its evaluation of prostatic lesions. Patients and methods: This prospective study included 38 patients with clinical suspicion of cancer prostate (increased PSA levels (>4 ng/ml, hard prostate in digital rectal examination and who are scheduled to undergo a TRUS-guided biopsy. Conventional and DW-MRI was done and ADC was calculated. The normalized ADC value was calculated by dividing the ADC of lesion by ADC of reference site (healthy peripheral zone. DWI-MRI results were compared to the results of biopsy. Comparison of ADCs and nADCs of benign and malignant lesions was done. Receiver operating characteristics (ROC curve analysis was done. Results: The patients were classified by histopathology into non-malignant group (16 patients and malignant group (22 patients. Significant negative correlation between ADC and normalized ADC (nADC and malignancy was detected. There was no significant difference between the mean ADC of peripheral health prostatic zones (PZ between benign and malignant cases (2.221 ± 0.356 versus 1.99 ± 0.538x10−3 mm2/sec, p = 0.144.There was significant difference between the mean ADC and mean nADC in benign and malignant lesions (1.049 ± 0.217 versus 0.659 ± 0.221x10−3 mm2/sec, p < 0.001 and (0.475 ± 0.055 versus 0.328 ± 0.044, p < 0.001 respectively.There was significant higher diagnostic performance of nADC than ADC with ADC Cut-off value 0.75 × 10−3 mm2/sec and nADC cut-off value 0.39 could significantly differentiate between benign and malignant lesion with sensitivity, specificity, PPV,NPV of 86.36,75,82.61 and 80% respectively, p < 0.0001 for ADC and 95.45, 93.75, 95.45 and 93.75%, p < 0.0001 for nADC. Conclusion: diagnostic performance of nADC using normal peripheral zone is higher than

High-Speed Photography

International Nuclear Information System (INIS)

Paisley, D.L.; Schelev, M.Y.

1998-01-01

The applications of high-speed photography to a diverse set of subjects including inertial confinement fusion, laser surgical procedures, communications, automotive airbags, lightning etc. are briefly discussed. (AIP) copyright 1998 Society of Photo-Optical Instrumentation Engineers

Attitude Determination and Control Subsystem (ADCS) Preparations for the EPOXI Flyby of Comet Hartley 2

Science.gov (United States)

Luna, Michael E.; Collins, Steven M.

2011-01-01

On November 4, 2010 the former "Deep Impact" spacecraft, renamed "EPOXI" for its extended mission, flew within 700km of comet 103P/Hartley 2. In July 2005, the spacecraft had previously imaged a probe impact of comet Tempel 1. The EPOXI flyby was the fifth close encounter of a spacecraft with a comet nucleus and marked the first time in history that two comet nuclei were imaged at close range with the same suite of onboard science instruments. This challenging objective made the function of the attitude determination and control subsystem (ADCS) critical to the successful execution of the EPOXI flyby.As part of the spacecraft flyby preparations, the ADCS operations team had to perform meticulous sequence reviews, implement complex spacecraft engineering and science activities and perform numerous onboard calibrations. ADCS contributions included design and execution of 10 trajectory correction maneuvers, the science calibration of the two telescopic instruments, an in-flight demonstration of high-rate turns between Earth and comet point, and an ongoing assessment of reaction wheel health. The ADCS team was also responsible for command sequences that included updates to the onboard ephemeris and sun sensor coefficients and implementation of reaction wheel assembly (RWA) de-saturations.

ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma.

Science.gov (United States)

Umanodan, Tomokazu; Fukukura, Yoshihiko; Kumagae, Yuichi; Shindo, Toshikazu; Nakajo, Masatoyo; Takumi, Koji; Nakajo, Masanori; Hakamada, Hiroto; Umanodan, Aya; Yoshiura, Takashi

2017-04-01

To determine the diagnostic performance of apparent diffusion coefficient (ADC) histogram analysis in diffusion-weighted (DW) magnetic resonance imaging (MRI) for differentiating adrenal adenoma from pheochromocytoma. We retrospectively evaluated 52 adrenal tumors (39 adenomas and 13 pheochromocytomas) in 47 patients (21 men, 26 women; mean age, 59.3 years; range, 16-86 years) who underwent DW 3.0T MRI. Histogram parameters of ADC (b-values of 0 and 200 [ADC 200 ], 0 and 400 [ADC 400 ], and 0 and 800 s/mm 2 [ADC 800 ])-mean, variance, coefficient of variation (CV), kurtosis, skewness, and entropy-were compared between adrenal adenomas and pheochromocytomas, using the Mann-Whitney U-test. Receiver operating characteristic (ROC) curves for the histogram parameters were generated to differentiate adrenal adenomas from pheochromocytomas. Sensitivity and specificity were calculated by using a threshold criterion that would maximize the average of sensitivity and specificity. Variance and CV of ADC 800 were significantly higher in pheochromocytomas than in adrenal adenomas (P histogram parameters for diagnosing adrenal adenomas (ADC 200 , 0.82; ADC 400 , 0.87; and ADC 800 , 0.92), with sensitivity of 84.6% and specificity of 84.6% (cutoff, ≤2.82) with ADC 200 ; sensitivity of 89.7% and specificity of 84.6% (cutoff, ≤2.77) with ADC 400 ; and sensitivity of 94.9% and specificity of 92.3% (cutoff, ≤2.67) with ADC 800 . ADC histogram analysis of DW MRI can help differentiate adrenal adenoma from pheochromocytoma. 3 J. Magn. Reson. Imaging 2017;45:1195-1203. © 2016 International Society for Magnetic Resonance in Medicine.

Multi-parameter CAMAC compatible ADC scanner

Energy Technology Data Exchange (ETDEWEB)

Midttun, G J; Ingebretsen, F [Oslo Univ. (Norway). Fysisk Inst.; Johnsen, P J [Norsk Data A.S., Box 163, Oekern, Oslo 5, Norway

1979-02-15

A fast ADC scanner for multi-parameter nuclear physics experiments is described. The scanner is based on a standard CAMAC crate, and data from several different experiments can be handled simultaneously through a direct memory access (DMA) channel. The implementation on a PDP-7 computer is outlined.

Assessment and quantification of sources of variability in breast apparent diffusion coefficient (ADC) measurements at diffusion weighted imaging

Energy Technology Data Exchange (ETDEWEB)

Giannotti, E., E-mail: ytteb84@hotmail.com [Breast Imaging Department, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Waugh, S., E-mail: shelley.waugh@nhs.net [Department of Medical Physics, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Department of Clinical Radiology, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Priba, L., E-mail: lpriba@nhs.net [Department of Medical Physics, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Davis, Z., E-mail: zoedavis@doctors.org.uk [Breast Imaging Department, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Crowe, E., E-mail: e.crowe@nhs.net [Department of Clinical Radiology, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Vinnicombe, S., E-mail: s.vinnicombe@dundee.ac.uk [Division of Imaging and Technology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY (United Kingdom)

2015-09-15

Highlights: • Inter-scan errors have minimal contribution to ADC measurement variability. • Intra-observer measures of ADC values in breast cancer are excellent. • ADC measures in whole tumour are more reproducible than minimum ADC measures. • ADC measurement error is most influenced by multiple readers. - Abstract: Purpose: Apparent Diffusion Coefficient (ADC) measurements are increasingly used for assessing breast cancer response to neoadjuvant chemotherapy although little data exists on ADC measurement reproducibility. The purpose of this work was to investigate and characterise the magnitude of errors in ADC measures that may be encountered in such follow-up studies- namely scanner stability, scan–scan reproducibility, inter- and intra- observer measures and the most reproducible measurement of ADC. Methods: Institutional Review Board approval was obtained for the prospective study of healthy volunteers and written consent acquired for the retrospective study of patient images. All scanning was performed on a 3.0-T MRI scanner. Scanner stability was assessed using an ice-water phantom weekly for 12 weeks. Inter-scan repeatability was assessed across two scans of 10 healthy volunteers (26–61 years; mean: 44.7 years). Inter- and intra-reader analysis repeatability was measured in 52 carcinomas from clinical patients (29–70 years; mean: 50.0 years) by measuring the whole tumor ADC value on a single slice with maximum tumor diameter (ADC{sub S}) and the ADC value of a small region of interest (ROI) on the same slice (ADC{sub min}). Repeatability was assessed using intraclass correlation coefficients (ICC) and coefficients of repeatability (CoR). Results: Scanner stability contributed 6% error to phantom ADC measurements (0.071 × 10{sup −3} mm{sup 2}/s; mean ADC = 1.089 × 10{sup −3} mm{sup 2}/s). The measured scan-scan CoR in the volunteers was 0.122 × 10{sup −3} mm{sup 2}/s, contributing an error of 8% to the mean measured values (ADC

SEAL FOR HIGH SPEED CENTRIFUGE

Science.gov (United States)

Skarstrom, C.W.

1957-12-17

A seal is described for a high speed centrifuge wherein the centrifugal force of rotation acts on the gasket to form a tight seal. The cylindrical rotating bowl of the centrifuge contains a closure member resting on a shoulder in the bowl wall having a lower surface containing bands of gasket material, parallel and adjacent to the cylinder wall. As the centrifuge speed increases, centrifugal force acts on the bands of gasket material forcing them in to a sealing contact against the cylinder wall. This arrangememt forms a simple and effective seal for high speed centrifuges, replacing more costly methods such as welding a closure in place.

A 5bit 1GS/s 2.7mW 0.05mm^2 asynchronous digital slope ADC in 90nm CMOS for IR UWB radio

NARCIS (Netherlands)

Ding, M.; Harpe, P.J.A.; Hegt, J.A.; Philips, K.J.P.; Groot, de H.W.H.; Roermund, van A.H.M.

2012-01-01

A 5bit 1GS/s 0.05mm2 4× time-interleaved asynchronous digital slope ADC in 90nm CMOS for IR UWB radio is presented. New delay cells are introduced to double the speed over prior art, yielding the 250MS/s single-channel slope converter. A self-disabled comparator eliminates static leakage and

High-Speed Data Recorder for Space, Geodesy, and Other High-Speed Recording Applications

Science.gov (United States)

Taveniku, Mikael

2013-01-01

A high-speed data recorder and replay equipment has been developed for reliable high-data-rate recording to disk media. It solves problems with slow or faulty disks, multiple disk insertions, high-altitude operation, reliable performance using COTS hardware, and long-term maintenance and upgrade path challenges. The current generation data recor - ders used within the VLBI community are aging, special-purpose machines that are both slow (do not meet today's requirements) and are very expensive to maintain and operate. Furthermore, they are not easily upgraded to take advantage of commercial technology development, and are not scalable to multiple 10s of Gbit/s data rates required by new applications. The innovation provides a softwaredefined, high-speed data recorder that is scalable with technology advances in the commercial space. It maximally utilizes current technologies without being locked to a particular hardware platform. The innovation also provides a cost-effective way of streaming large amounts of data from sensors to disk, enabling many applications to store raw sensor data and perform post and signal processing offline. This recording system will be applicable to many applications needing realworld, high-speed data collection, including electronic warfare, softwaredefined radar, signal history storage of multispectral sensors, development of autonomous vehicles, and more.

Diffusion-weighted magnetic resonance imaging for the initial characterization of non-fatty soft tissue tumors: correlation between T2 signal intensity and ADC values

Energy Technology Data Exchange (ETDEWEB)

Gondim Teixeira, Pedro Augusto [Service d' Imagerie Guilloz, CHU Nancy, Nancy (France); Universite de Lorraine, IADI, UMR S 947, Vandoeuvre-les-Nancy (France); Gay, Frederique; Blum, Alain [Service d' Imagerie Guilloz, CHU Nancy, Nancy (France); Chen, Bailiang; Felblinger, Jacques [Universite de Lorraine, IADI, UMR S 947, Vandoeuvre-les-Nancy (France); Zins, Marie [University Versailles St-Quentin, Versailles (France); Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif (France); Sirveaux, Francois [Centre Chirurgical Emile Galle, Service de Chirurgie Traumatologique et Orthopedique, Nancy (France)

2016-02-15

To evaluate the performance of quantitative diffusion-weighted imaging (DWI) correlated with T2 signal in differentiating non-fatty benign from malignant tumors. A total of 76 patients with a histologically confirmed non-fatty soft tissue tumors (46 benign and 30 malignant) were prospectively included in this ethics committee approved study. All patients signed an informed consent and underwent MRI with DWI with two b values (0 and 600). ADC values from the solid components of these tumors were obtained and were correlated with the lesion's signal intensity on T2-weighted fat-saturated sequences. ADC values were obtained from adjacent normal muscle to allow calculation of tumor/muscle ADC ratios. There were 58 hyperintense and 18 iso or hypointense lesions. All hypointense lesions were benign. The mean ADC values for benign and malignant tumors were 1.47 ± 0.54 x 10{sup -3} and 1.17 ± 0.38 x 10{sup -3} mm{sup 2}/s respectively (p < 0.005). The mean ADC ratio in benign iso or hypointense tumors was significantly lower than that of hyperintense ones (0.76 ± 0.21 versus 1.58 ± 0.82 - p < 0.0001). An ADC ratio lower than 0.915 was highly specific for malignancy (96.4 %), whereas an ADC ratio higher than 1.32 was highly sensitive for benign lesions (90 %). ADC analysis can be useful in the initial characterization of T2 hyperintense non-fatty soft tissue masses, although this technique alone is not likely to change patient management. (orig.)

The high speed civil transport and NASA's High Speed Research (HSR) program

Science.gov (United States)

Shaw, Robert J.

1994-01-01

Ongoing studies being conducted not only in this country but in Europe and Asia suggest that a second generation supersonic transport, or High-Speed Civil Transport (HSCT), could become an important part of the 21st century international air transportation system. However, major environmental compatibility and economic viability issues must be resolved if the HSCT is to become a reality. This talk will overview the NASA High-Speed Research (HSR) program which is aimed at providing the U.S. industry with a technology base to allow them to consider launching an HSCT program early in the next century. The talk will also discuss some of the comparable activities going on within Europe and Japan.

Using a High-Speed Camera to Measure the Speed of Sound

Science.gov (United States)

Hack, William Nathan; Baird, William H.

2012-01-01

The speed of sound is a physical property that can be measured easily in the lab. However, finding an inexpensive and intuitive way for students to determine this speed has been more involved. The introduction of affordable consumer-grade high-speed cameras (such as the Exilim EX-FC100) makes conceptually simple experiments feasible. Since the…

Broadband Data Converter Technical Presentation at CERN by e2v and ANATEC

CERN Multimedia

FI Department

2008-01-01

12 September 2008 10:00 – 11:45, Room B Main Building. Technical presentation e2v and ANATEC. e2v Grenoble (http://www.e2v.com) designs and manufactures standard and custom low latency and high speed ADCs that are true single core ADCs. Sampling speeds without interleaving range from 500MSPS to beyond 2.2GSPS with resolution ranging from 8 bits to 10bits and input bandwidths exceed 2.5GHz. With built-in interleaving feature some e2v multi-channel ADCs can reach 5GSPS sampling speed per device. e2v is known to offer 8, 10 and 12 bit ADCs with very low latency, exceptional linearity at high input frequency, that is in the 2nd Nyquist zone and beyond for some devices. This seminar will cover the following topics: Overview of existing standard 8bit, 10bit and 12bit ADCs up to 5GSPS. Key aspects of the e2v broadband ADC architecture. Benefits of true single core ADCs without internal interleaving. Choice of several possibilities to drive the ADC inputs, DC coupling at high spe...

33 CFR 84.24 - High-speed craft.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false High-speed craft. 84.24 Section... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.24 High-speed craft. (a) The masthead light of high-speed craft with a length to breadth ratio of less than 3.0 may be placed at a...

Diffusion MRI for rectal cancer staging: ADC measurements before and after ultrasonographic gel lumen distension

Energy Technology Data Exchange (ETDEWEB)

Palmucci, S., E-mail: spalmucci@sirm.org; Piccoli, M.; Piana, S.; Foti, P.V.; Siverino, R.O.A.; Mauro, L.A.; Milone, P.; Ettorre, G.C.

2017-01-15

Objectives: To compare Apparent Diffusion Coefficient (ADC) measurements in rectal neoplastic lesions before and after lumen distension obtained with sonography transmission gel. Methods: From January 2014 to July 2016, 25 patients (average age 63.7, range 41–85, 18 males) were studied for pre-treatment rectal cancer staging using a 1.5 T MRI. Diffusion MRI was obtained using echo-planar imaging with b = 800 value; all patients were studied acquiring diffusion sequences with and without rectal lumen distension obtained using sonography transmission gel. In both diffusion sequences, two blinded readers calculated border ADC values and small ADC values, drawing regions of interest respectively along tumour borders and far from tumour borders. Mean ADC values among readers − for each type of ADC measurement − were compared using Wilcoxon matched pairs signed rank test. Correlation was assessed using Pearson analysis. Results: Border ADC mean value for diffusion MR sequences without endorectal contrast was 1.122 mm{sup 2}/sec, with 95% Confidence Interval (CI) = 1.02–1.22; using gel lumen distension, higher border ADC mean value of 1.269 mm{sup 2}/s (95% CI = 1.16–1.38) was obtained. Wilcoxon matched pairs signed rank test revealed statistical difference (p < 0.01); a strong Pearson correlation was reported, with r value of 0.69. Small-ADC mean value was 1.038 mm{sup 2}/s (95% CI = 0.91–1.16) for diffusion sequences acquired without endorectal distension and 1.127 mm{sup 2}/s (95% CI = 0.98–1.27) for diffusion sequences obtained after endorectal gel lumen distension. Wilcoxon analysis did not show statistical difference (p = 0.13). A very strong positive correlation was observed, with r value of 0.81. Conclusions: ADC measurements are slightly higher using endorectal sonographic transmission gel; ROI should be traced far from tumour borders, to minimize gel filled-pixel along the interface between lumen and lesion. Further studies are needed to

Diffusion MRI for rectal cancer staging: ADC measurements before and after ultrasonographic gel lumen distension

International Nuclear Information System (INIS)

Palmucci, S.; Piccoli, M.; Piana, S.; Foti, P.V.; Siverino, R.O.A.; Mauro, L.A.; Milone, P.; Ettorre, G.C.

2017-01-01

Objectives: To compare Apparent Diffusion Coefficient (ADC) measurements in rectal neoplastic lesions before and after lumen distension obtained with sonography transmission gel. Methods: From January 2014 to July 2016, 25 patients (average age 63.7, range 41–85, 18 males) were studied for pre-treatment rectal cancer staging using a 1.5 T MRI. Diffusion MRI was obtained using echo-planar imaging with b = 800 value; all patients were studied acquiring diffusion sequences with and without rectal lumen distension obtained using sonography transmission gel. In both diffusion sequences, two blinded readers calculated border ADC values and small ADC values, drawing regions of interest respectively along tumour borders and far from tumour borders. Mean ADC values among readers − for each type of ADC measurement − were compared using Wilcoxon matched pairs signed rank test. Correlation was assessed using Pearson analysis. Results: Border ADC mean value for diffusion MR sequences without endorectal contrast was 1.122 mm 2 /sec, with 95% Confidence Interval (CI) = 1.02–1.22; using gel lumen distension, higher border ADC mean value of 1.269 mm 2 /s (95% CI = 1.16–1.38) was obtained. Wilcoxon matched pairs signed rank test revealed statistical difference (p < 0.01); a strong Pearson correlation was reported, with r value of 0.69. Small-ADC mean value was 1.038 mm 2 /s (95% CI = 0.91–1.16) for diffusion sequences acquired without endorectal distension and 1.127 mm 2 /s (95% CI = 0.98–1.27) for diffusion sequences obtained after endorectal gel lumen distension. Wilcoxon analysis did not show statistical difference (p = 0.13). A very strong positive correlation was observed, with r value of 0.81. Conclusions: ADC measurements are slightly higher using endorectal sonographic transmission gel; ROI should be traced far from tumour borders, to minimize gel filled-pixel along the interface between lumen and lesion. Further studies are needed to investigate better

Predicting Treatment Response of Colorectal Cancer Liver Metastases to Conventional Lipiodol-Based Transarterial Chemoembolization Using Diffusion-Weighted MR Imaging: Value of Pretreatment Apparent Diffusion Coefficients (ADC) and ADC Changes Under Therapy

International Nuclear Information System (INIS)

Lahrsow, Maximilian; Albrecht, Moritz H.; Bickford, Matthew W.; Vogl, Thomas J.

2017-01-01

PurposeTo use absolute pretreatment apparent diffusion coefficients (ADC) derived from diffusion-weighted MR imaging (DWI) to predict response to repetitive cTACE for unresectable liver metastases of colorectal carcinoma (CRLM) at 1 and 3 months after start of treatment.Materials and MethodsFifty-five metastases in 34 patients were examined with DWI prior to treatment and 1 month after initial cTACE. Treatment was performed in 4-week intervals. Response was evaluated at 1 and 3 months after start of therapy. Metastases showing a decrease of ≥30% in axial diameter were classified as responding lesions.ResultsOne month after initial cTACE, seven lesions showed early response. There was no significant difference in absolute pretreatment ADC values between responding and non-responding lesions (p = 0.94). Three months after initial cTACE, 17 metastases showed response. There was a significant difference (p = 0.021) between absolute pretreatment ADC values of lesions showing response (median 1.08 × 10 −3  mm 2 /s) and no response (median 1.30 × 10 −3  mm 2 /s). Pretreatment ADC showed fair diagnostic value to predict response (AUC 0.7). Lesions showing response at 3 months also revealed a significant increase in ADC between measurements before treatment and at one month after initial cTACE (p < 0.001). Applying an increase in ADC of 12.17%, response at 3 months after initial cTACE could be predicted with a sensitivity and specificity of 77 and 74%, respectively (AUC 0.817). Furthermore, there was a strong and significant correlation (r = 0.651, p < 0.001) between percentage change in size after third cTACE and percentage change in ADC.ConclusionIn patients with CRLM, ADC measurements are potential biomarkers for assessing response to cTACE.

Predicting Treatment Response of Colorectal Cancer Liver Metastases to Conventional Lipiodol-Based Transarterial Chemoembolization Using Diffusion-Weighted MR Imaging: Value of Pretreatment Apparent Diffusion Coefficients (ADC) and ADC Changes Under Therapy

Energy Technology Data Exchange (ETDEWEB)

Lahrsow, Maximilian, E-mail: mlahrsow@gmail.com; Albrecht, Moritz H. [University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology (Germany); Bickford, Matthew W. [Medical University of South Carolina, Department of Radiology and Radiological Science (United States); Vogl, Thomas J. [University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology (Germany)

2017-06-15

PurposeTo use absolute pretreatment apparent diffusion coefficients (ADC) derived from diffusion-weighted MR imaging (DWI) to predict response to repetitive cTACE for unresectable liver metastases of colorectal carcinoma (CRLM) at 1 and 3 months after start of treatment.Materials and MethodsFifty-five metastases in 34 patients were examined with DWI prior to treatment and 1 month after initial cTACE. Treatment was performed in 4-week intervals. Response was evaluated at 1 and 3 months after start of therapy. Metastases showing a decrease of ≥30% in axial diameter were classified as responding lesions.ResultsOne month after initial cTACE, seven lesions showed early response. There was no significant difference in absolute pretreatment ADC values between responding and non-responding lesions (p = 0.94). Three months after initial cTACE, 17 metastases showed response. There was a significant difference (p = 0.021) between absolute pretreatment ADC values of lesions showing response (median 1.08 × 10{sup −3} mm{sup 2}/s) and no response (median 1.30 × 10{sup −3} mm{sup 2}/s). Pretreatment ADC showed fair diagnostic value to predict response (AUC 0.7). Lesions showing response at 3 months also revealed a significant increase in ADC between measurements before treatment and at one month after initial cTACE (p < 0.001). Applying an increase in ADC of 12.17%, response at 3 months after initial cTACE could be predicted with a sensitivity and specificity of 77 and 74%, respectively (AUC 0.817). Furthermore, there was a strong and significant correlation (r = 0.651, p < 0.001) between percentage change in size after third cTACE and percentage change in ADC.ConclusionIn patients with CRLM, ADC measurements are potential biomarkers for assessing response to cTACE.

Modern trends in designing high-speed trains

Directory of Open Access Journals (Sweden)

Golubović Snežana D.

2015-01-01

Full Text Available Increased advantages of railway transportation systems over other types of transportation systems in the past sixty years have been a result of an intensive development of the new generations of high-speed trains. Not only do these types of trains comply with the need for increased speed of transportation and make the duration of the journey shorter, but they also meet the demands for increased reliability, safety and direct application of energy efficiency to the transportation system itself. Along with increased train speed, the motion resistance is increased as well, whereby at speeds over 200 km/h the proportion of air resistance becomes the most dominant member. One of the most efficient measures for reducing air resistance, as well as other negative consequences of high-speed motion, is the development of the aerodynamic shape of the train. This paper presents some construction solutions that affect the aerodynamic properties of high-speed trains, first and foremost, the nose shape, as well as the similarities and differences of individual subsystems necessary for the functioning of modern high-speed rail systems. We analysed two approaches to solving the problem of the aerodynamic shape of the train and the appropriate infrastructure using the examples of Japan and France. Two models of high-speed trains, Shinkansen (Japan and TGV, i.e. AGV (France, have been discussed.

High Speed Digitizer for Remote Sensing, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Alphacore, Inc. proposes to design and characterize a 24Gsps (giga-samples per-second), 6-bit, low-power, and low-cost analog-to-digital converter (ADC) for use in a...

Apparent Diffusion Coefficient (ADC) value: a potential imaging biomarker that reflects the biological features of rectal cancer.

Science.gov (United States)

Sun, Yiqun; Tong, Tong; Cai, Sanjun; Bi, Rui; Xin, Chao; Gu, Yajia

2014-01-01

We elected to analyze the correlation between the pre-treatment apparent diffusion coefficient (ADC) and the clinical, histological, and immunohistochemical status of rectal cancers. Forty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI and diffusion-weighted imaging (DWI). Tumor ADC values were determined and analyzed to identify any correlations between these values and pre-treatment CEA or CA19-9 levels, and/or the histological and immunohistochemical properties of the tumor. Inter-observer agreement of confidence levels from two separate observers was suitable for ADC measurement (k  =  0.775). The pre-treatment ADC values of different T stage tumors were not equal (p  =  0.003). The overall trend was that higher T stage values correlated with lower ADC values. ADC values were also significantly lower for the following conditions: tumors with the presence of extranodal tumor deposits (p  =  0.006) and tumors with CA19-9 levels ≥ 35 g/ml (p  =  0.006). There was a negative correlation between Ki-67 LI and the ADC value (r  =  -0.318, p  =  0.026) and between the AgNOR count and the ADC value (r  =  -0.310, p  =  0.030). Significant correlations were found between the pre-treatment ADC values and T stage, extranodal tumor deposits, CA19-9 levels, Ki-67 LI, and AgNOR counts in our study. Lower ADC values were associated with more aggressive tumor behavior. Therefore, the ADC value may represent a useful biomarker for assessing the biological features and possible relationship to the status of identified rectal cancers.

Changes of indicators of high-speed and high-speed and power preparedness at volleyball players of 12–13 years old

Directory of Open Access Journals (Sweden)

Oleg Shevchenko

2016-04-01

Full Text Available Purpose: to define changes of indicators of high-speed and high-speed and power preparedness of volleyball players of 12–13 years old. Material & Methods: the test exercises, which are recommended by the training program of CYSS on volleyball, were used for the definition of the level of development of high-speed and high-speed and power abilities of volleyball players. 25 young volleyball players from the group of the previous basic preparation took part in the experiment. Sports experience of sportsmen is 3–4 years. The analysis of scientifically-methodical literature, pedagogical testing, pedagogical experiment, methods of mathematical statistics were carried out. Results: the analyzed level of high-speed and high-speed and power abilities of volleyball players. Conclusions: the results had reliable changes (t=2,2–2,4 at р<0,05 of the level of high-speed and high-speed and power abilities of volleyball players of 12–13years old in the experimental group at the end of the experiment, except run on 30 m that demonstrates a positive influence of application of special exercises in the educational-training process.

Reducing Heating In High-Speed Cinematography

Science.gov (United States)

Slater, Howard A.

1989-01-01

Infrared-absorbing and infrared-reflecting glass filters simple and effective means for reducing rise in temperature during high-speed motion-picture photography. "Hot-mirror" and "cold-mirror" configurations, employed in projection of images, helps prevent excessive heating of scenes by powerful lamps used in high-speed photography.

High speed data acquisition

International Nuclear Information System (INIS)

Cooper, P.S.

1997-07-01

A general introduction to high speed data acquisition system techniques in modern particle physics experiments is given. Examples are drawn from the SELEX(E78 1) high statistics charmed baryon production and decay experiment now taking data at Fermilab

Wake flow characteristics at high wind speed

DEFF Research Database (Denmark)

Aagaard Madsen, Helge; Larsen, Torben J.; Larsen, Gunner Chr.

2016-01-01

Wake flow characteristic at high wind speeds is the main subject of this paper. Although the wake losses decrease at high wind speeds it has been found in a recent study that for multiple wake inflow the increase in loading due to wake effects are substantial even at wind speeds well above rated ...

Fast ADC interface with data reduction facilities for multi-parameter experiments in nuclear physics

Energy Technology Data Exchange (ETDEWEB)

Liebl, W; Franz, N; Ziegler, G [Technische Univ. Muenchen, Garching (Germany, F.R.). Fakultaet Physik; Hegewisch, S; Kunz, D; Maier, D; Lutter, R; Schoeffel, K; Stanzel, B [Muenchen Univ. (Germany, F.R.). Sektion Physik; Drescher, B [Hahn-Meitner-Institut fuer Kernforschung Berlin G.m.b.H. (Germany, F.R.)

1982-03-01

A modular ADC interface system for multi-parameter experiments with single NIM ADCs is described. 16 fast ADCs are handled by CAMAC modules and data buses in order to build up a sophisticated hardware system which is able to take coincidence data and singles spectra in parallel. The coincidence logic is handled by one of the interface modules; the interface allows online data reduction. The further expansion of the system will be discussed.

Apparent Diffusion Coefficient (ADC value: a potential imaging biomarker that reflects the biological features of rectal cancer.

Directory of Open Access Journals (Sweden)

Yiqun Sun

Full Text Available OBJECTIVE: We elected to analyze the correlation between the pre-treatment apparent diffusion coefficient (ADC and the clinical, histological, and immunohistochemical status of rectal cancers. MATERIALS AND METHODS: Forty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI and diffusion-weighted imaging (DWI. Tumor ADC values were determined and analyzed to identify any correlations between these values and pre-treatment CEA or CA19-9 levels, and/or the histological and immunohistochemical properties of the tumor. RESULTS: Inter-observer agreement of confidence levels from two separate observers was suitable for ADC measurement (k  =  0.775. The pre-treatment ADC values of different T stage tumors were not equal (p  =  0.003. The overall trend was that higher T stage values correlated with lower ADC values. ADC values were also significantly lower for the following conditions: tumors with the presence of extranodal tumor deposits (p  =  0.006 and tumors with CA19-9 levels ≥ 35 g/ml (p  =  0.006. There was a negative correlation between Ki-67 LI and the ADC value (r  =  -0.318, p  =  0.026 and between the AgNOR count and the ADC value (r  =  -0.310, p  =  0.030. CONCLUSION: Significant correlations were found between the pre-treatment ADC values and T stage, extranodal tumor deposits, CA19-9 levels, Ki-67 LI, and AgNOR counts in our study. Lower ADC values were associated with more aggressive tumor behavior. Therefore, the ADC value may represent a useful biomarker for assessing the biological features and possible relationship to the status of identified rectal cancers.

A 100 MS/s 9 bit 0.43 mW SAR ADC with custom capacitor array

Science.gov (United States)

Jingjing, Wang; Zemin, Feng; Rongjin, Xu; Chixiao, Chen; Fan, Ye; Jun, Xu; Junyan, Ren

2016-05-01

A low power 9 bit 100 MS/s successive approximation register analog-to-digital converter (SAR ADC) with custom capacitor array is presented. A brand-new 3-D MOM unit capacitor is used as the basic capacitor cell of this capacitor array. The unit capacitor has a capacitance of 1 fF. Besides, the advanced capacitor array structure and switch mode decrease the power consumption a lot. To verify the effectiveness of this low power design, the 9 bit 100 MS/s SAR ADC is implemented in TSMC IP9M 65 nm LP CMOS technology. The measurement results demonstrate that this design achieves an effective number of bits (ENOB) of 7.4 bit, a signal-to-noise plus distortion ratio (SNDR) of 46.40 dB and a spurious-free dynamic range (SFDR) of 62.31 dB at 100 MS/s with 1 MHz input. The SAR ADC core occupies an area of 0.030 mm2 and consumes 0.43 mW under a supply voltage of 1.2 V. The figure of merit (FOM) of the SAR ADC achieves 23.75 fJ/conv. Project supported by the National High-Tech Research and Development Program of China (No. 2013AA014101).

14 CFR 25.253 - High-speed characteristics.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false High-speed characteristics. 25.253 Section...-speed characteristics. (a) Speed increase and recovery characteristics. The following speed increase and recovery characteristics must be met: (1) Operating conditions and characteristics likely to cause...

Chicago-St. Louis high speed rail plan

International Nuclear Information System (INIS)

Stead, M.E.

1994-01-01

The Illinois Department of Transportation (IDOT), in cooperation with Amtrak, undertook the Chicago-St. Louis High Speed Rail Financial and Implementation Plan study in order to develop a realistic and achievable blueprint for implementation of high speed rail in the Chicago-St. Louis corridor. This report presents a summary of the Price Waterhouse Project Team's analysis and the Financial and Implementation Plan for implementing high speed rail service in the Chicago-St. Louis corridor

Chicago-St. Louis high speed rail plan

Energy Technology Data Exchange (ETDEWEB)

Stead, M.E.

1994-12-31

The Illinois Department of Transportation (IDOT), in cooperation with Amtrak, undertook the Chicago-St. Louis High Speed Rail Financial and Implementation Plan study in order to develop a realistic and achievable blueprint for implementation of high speed rail in the Chicago-St. Louis corridor. This report presents a summary of the Price Waterhouse Project Team`s analysis and the Financial and Implementation Plan for implementing high speed rail service in the Chicago-St. Louis corridor.

Lubrication and cooling for high speed gears

Science.gov (United States)

Townsend, D. P.

1985-01-01

The problems and failures occurring with the operation of high speed gears are discussed. The gearing losses associated with high speed gearing such as tooth mesh friction, bearing friction, churning, and windage are discussed with various ways shown to help reduce these losses and thereby improve efficiency. Several different methods of oil jet lubrication for high speed gearing are given such as into mesh, out of mesh, and radial jet lubrication. The experiments and analytical results for the various methods of oil jet lubrication are shown with the strengths and weaknesses of each method discussed. The analytical and experimental results of gear lubrication and cooling at various test conditions are presented. These results show the very definite need of improved methods of gear cooling at high speed and high load conditions.

A SAR-ADC using unit bridge capacitor and with calibration for the front-end electronics of PET imaging

Energy Technology Data Exchange (ETDEWEB)

Liu, Wei [School of Computer Science and Engineering, Northwestern Polytechnical University, Xi' an 710072, Shaanxi (China); Wei, Tingcun, E-mail: weitc@nwpu.edu.cn [School of Computer Science and Engineering, Northwestern Polytechnical University, Xi' an 710072, Shaanxi (China); Li, Bo; Yang, Lifeng; Xue, Feifei [School of Computer Science and Engineering, Northwestern Polytechnical University, Xi' an 710072, Shaanxi (China); Hu, Yongcai [Institut Pluridisciplinaire Hubert CURIEN, Strasbourg (France)

2016-05-11

This paper presents a 12-bit 1 MS/s successive approximation register-analog to digital converter (SAR-ADC) for the 32-channel front-end electronics of CZT-based PET imaging system. To reduce the capacitance mismatch, instead of the fractional capacitor, the unit capacitor is used as the bridge capacitor in the split-capacitor digital to analog converter (DAC) circuit. In addition, in order to eliminate the periodical DNL errors of −1 LSB which often exists in the SAR-ADC using the charge-redistributed DAC, a calibration algorithm is proposed and verified by the experiments. The proposed 12-bit 1 MS/s SAR-ADC is designed and implemented using a 0.35 μm CMOS technology, it occupies only an active area of 986×956 μm{sup 2}. The measurement results show that, at the power supply of 3.3/5.0 V and the sampling rate of 1 MS/s, the ADC with calibration has a signal-to-noise-and-distortion ratio (SINAD) of 67.98 dB, the power dissipation of 5 mW, and a figure of merit (FOM) of 2.44 pJ/conv.-step. This ADC is with the features of high accuracy, low power and small layout area, it is especially suitable to the one-chip integration of the front-end readout electronics.

A continuous-time/discrete-time mixed audio-band sigma delta ADC

International Nuclear Information System (INIS)

Liu Yan; Hua Siliang; Wang Donghui; Hou Chaohuan

2011-01-01

This paper introduces a mixed continuous-time/discrete-time, single-loop, fourth-order, 4-bit audio-band sigma delta ADC that combines the benefits of continuous-time and discrete-time circuits, while mitigating the challenges associated with continuous-time design. Measurement results show that the peak SNR of this ADC reaches 100 dB and the total power consumption is less than 30 mW. (semiconductor integrated circuits)

The use of high-speed imaging in education

Science.gov (United States)

Kleine, H.; McNamara, G.; Rayner, J.

2017-02-01

Recent improvements in camera technology and the associated improved access to high-speed camera equipment have made it possible to use high-speed imaging not only in a research environment but also specifically for educational purposes. This includes high-speed sequences that are created both with and for a target audience of students in high schools and universities. The primary goal is to engage students in scientific exploration by providing them with a tool that allows them to see and measure otherwise inaccessible phenomena. High-speed imaging has the potential to stimulate students' curiosity as the results are often surprising or may contradict initial assumptions. "Live" demonstrations in class or student- run experiments are highly suitable to have a profound influence on student learning. Another aspect is the production of high-speed images for demonstration purposes. While some of the approaches known from the application of high speed imaging in a research environment can simply be transferred, additional techniques must often be developed to make the results more easily accessible for the targeted audience. This paper describes a range of student-centered activities that can be undertaken which demonstrate how student engagement and learning can be enhanced through the use of high speed imaging using readily available technologies.

High-speed elevators controlled by inverters

Energy Technology Data Exchange (ETDEWEB)

Sakai, Yoshio; Takahashi, Hideaki; Nakamura, Kiyoshi; Kinoshita, Hiroshi

1988-10-25

The super-high-speed elevator with superiority to 300m/min of speed, requires both the large capacity power and wide range speed controls. Therefore, in order to materialize the smooth and quiet operation characteristics, by applying the inverter control, the low torque ripple control in the low frequency range and high frequency large capacity inverting for lowering the motor in noise are necessary with their being assured of reliability. To satisfy the above necessary items, together with the development of a sine wave pulse width and frequency modulation (PWM/PFM) control system, to more precisely enable the sine wave electric current control, and 3kHz switching power converter, using a 800A power transistor module, a supervoltage control circuit under the extraordinary condition was designed. As a result of commercializing a 360m/min super-high speed inverter elevator, the power source unit, due to the effect of high power factor, could be reduced by 30% in capacity and also the higher harmonic wave including ratio could be considerably lowered to the inferiority to 5%. 2 references, 7 figures, 1 table.

High - speed steel for precise cased tools

International Nuclear Information System (INIS)

Karwiarz, J.; Mazur, A.

2001-01-01

The test results of high-vanadium high - speed steel (SWV9) for precise casted tools are presented. The face -milling cutters of NFCa80A type have been tested in industrial operating conditions. An average life - time of SWV9 steel tools was 3-10 times longer compare to the conventional high - speed milling cutters. Metallography of SWB9 precise casted steel revealed beneficial for tool properties distribution of primary vanadium carbides in the steel matrix. Presented results should be a good argument for wide application of high - vanadium high - speed steel for precise casted tools. (author)

A custom floating point format ADC for LHC calorimetry

International Nuclear Information System (INIS)

Hermel, V.; Lecoq, J.; Bohner, G.

1996-01-01

Due to their large dynamic range (in excess of 16 bits) signals from LHC calorimetry poses severe problems to the shaping and digitizing circuits. We are investigating a solution for an ADC based on a custom floating point format. Since the calorimeter precision is limited, the full dynamic range can be split into 8 positive sub-ranges and 5 negative ones, each with an 8 bits dynamic. The reduced number of bits (8 for the mantissa, 4 for the exponent and 1 for the sign) translates itself into a reduction of the power consumption both of the ADC and of the following digital filtering stages. (authors)

Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps.

Science.gov (United States)

Ren, Jiliang; Yuan, Ying; Wu, Yingwei; Tao, Xiaofeng

2018-05-02

The overlap of morphological feature and mean ADC value restricted clinical application of MRI in the differential diagnosis of orbital lymphoma and idiopathic orbital inflammatory pseudotumor (IOIP). In this paper, we aimed to retrospectively evaluate the combined diagnostic value of conventional magnetic resonance imaging (MRI) and whole-tumor histogram analysis of apparent diffusion coefficient (ADC) maps in the differentiation of the two lesions. In total, 18 patients with orbital lymphoma and 22 patients with IOIP were included, who underwent both conventional MRI and diffusion weighted imaging before treatment. Conventional MRI features and histogram parameters derived from ADC maps, including mean ADC (ADC mean ), median ADC (ADC median ), skewness, kurtosis, 10th, 25th, 75th and 90th percentiles of ADC (ADC 10 , ADC 25 , ADC 75 , ADC 90 ) were evaluated and compared between orbital lymphoma and IOIP. Multivariate logistic regression analysis was used to identify the most valuable variables for discriminating. Differential model was built upon the selected variables and receiver operating characteristic (ROC) analysis was also performed to determine the differential ability of the model. Multivariate logistic regression showed ADC 10 (P = 0.023) and involvement of orbit preseptal space (P = 0.029) were the most promising indexes in the discrimination of orbital lymphoma and IOIP. The logistic model defined by ADC 10 and involvement of orbit preseptal space was built, which achieved an AUC of 0.939, with sensitivity of 77.30% and specificity of 94.40%. Conventional MRI feature of involvement of orbit preseptal space and ADC histogram parameter of ADC 10 are valuable in differential diagnosis of orbital lymphoma and IOIP.

A FASTBUS flash ADC system for the Mark II vertex chamber

International Nuclear Information System (INIS)

Barker, L.

1988-10-01

This is a description of a flash ADC system built for the Mark II experiment at the Stanford Linear Accelerator Center (SLAC). This system was designed for use in the experiment's vertex chamber where signals could occur over a relatively long time, approximately 10 microseconds. This long time, coupled with fast cable amplifiers, necessitated an alternate design approach than was used with a dE/dX FASTBUS flash ADC design. 1 ref., 6 figs

Apparent diffusion coefficient (ADC) does not correlate with different serological parameters in myositis and myopathy.

Science.gov (United States)

Meyer, Hans-Jonas; Ziemann, Oliver; Kornhuber, Malte; Emmer, Alexander; Quäschling, Ulf; Schob, Stefan; Surov, Alexey

2018-06-01

Background Magnetic resonance imaging (MRI) is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an imaging modality, which can reflect microstructural tissue composition. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules in tissue. Purpose To investigate ADC values in patients with myositis and non-inflammatory myopathy and to analyze possible associations between ADC and laboratory parameters in these patients. Material and Methods Overall, 17 patients with several myositis entities, eight patients with non-inflammatory myopathies, and nine patients without muscle disorder as a control group were included in the study (mean age = 55.3 ± 14.3 years). The diagnosis was confirmed by histopathology in every case. DWI was obtained in a 1.5-T scanner using two b-values: 0 and 1000 s/mm 2 . In all patients, the blood sample was acquired within three days to the MRI. The following serological parameters were estimated: C-reactive protein, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, and myoglobine. Results The estimated mean ADC value for the myositis group was 1.89 ± 0.37 × 10 -3  mm 2 /s and for the non-inflammatory myopathy group was 1.79 ± 0.33 × 10 -3  mm 2 /s, respectively. The mean ADC values (1.15 ± 0.37 × 10 -3  mm 2 /s) were significantly higher to unaffected muscles (vs. myositis P = 0.0002 and vs. myopathy P = 0.0021). There were no significant correlations between serological parameters and ADC values. Conclusion Affected muscles showed statistically significantly higher ADC values than normal muscles. No linear correlations between ADC and serological parameters were identified.

High-speed ground transportation development outside United States

Energy Technology Data Exchange (ETDEWEB)

Eastham, T.R. [Queen`s Univ., Kingston, Ontario (United Kingdom)

1995-09-01

This paper surveys the state of high-speed (in excess of 200 km/h) ground-transportation developments outside the United States. Both high-speed rail and Maglev systems are covered. Many vehicle systems capable of providing intercity service in the speed range 200--500 km/h are or will soon be available. The current state of various technologies, their implementation, and the near-term plans of countries that are most active in high-speed ground transportation development are reported.

Aerodynamic design on high-speed trains

Science.gov (United States)

Ding, San-San; Li, Qiang; Tian, Ai-Qin; Du, Jian; Liu, Jia-Li

2016-04-01

Compared with the traditional train, the operational speed of the high-speed train has largely improved, and the dynamic environment of the train has changed from one of mechanical domination to one of aerodynamic domination. The aerodynamic problem has become the key technological challenge of high-speed trains and significantly affects the economy, environment, safety, and comfort. In this paper, the relationships among the aerodynamic design principle, aerodynamic performance indexes, and design variables are first studied, and the research methods of train aerodynamics are proposed, including numerical simulation, a reduced-scale test, and a full-scale test. Technological schemes of train aerodynamics involve the optimization design of the streamlined head and the smooth design of the body surface. Optimization design of the streamlined head includes conception design, project design, numerical simulation, and a reduced-scale test. Smooth design of the body surface is mainly used for the key parts, such as electric-current collecting system, wheel truck compartment, and windshield. The aerodynamic design method established in this paper has been successfully applied to various high-speed trains (CRH380A, CRH380AM, CRH6, CRH2G, and the Standard electric multiple unit (EMU)) that have met expected design objectives. The research results can provide an effective guideline for the aerodynamic design of high-speed trains.

A 72-dB-SNDR rail-to-rail successive approximation ADC using mismatch calibration techniques

International Nuclear Information System (INIS)

Liu Yan; Hua Siliang; Wang Donghui; Hou Chaohuan

2012-01-01

When the voltage of an analog input signal is equal to the supply voltage, it is difficult for a conventional successive approximation ADC to correctly convert the analog signal into digital signal. This paper introduces an improved successive approximation ADC, which can convert the rail-to-rail input range and reduce sampling time through a track-and-hold circuit. Comparator offset cancellation and capacitor self-calibration techniques are used in this ADC. Measurement results show that the peak SNDR of this ADC reaches 72 dB and the signal effective bandwidth is up to 1.25 MHz. It consumes 1 mW in the test, and the figure of merit is 123 fJ/conversion-step. (semiconductor integrated circuits)

A design technique of low cost but high quality peak stretcher

Energy Technology Data Exchange (ETDEWEB)

Lo, H Y; Su, C S; Hsu, J Y; Wang, L

1981-03-01

This paper presents the design of low cost but high quality pulse peak stretcher incorporated with a LSI of 12 bit ADC and SKD-85 microcomputer. The conflict between the capacitor high charging speed and longer holding time for realizing a high quality stretcher is discussed and solved. For a lager number of channels available in a dual ramp Wilkinson-type ADC, two-stage stretchers connected in series are designed. The first stage is a fast-discharge to keep the output stretched pulse follow-up the input quickly and the second-stage (main stretcher) is a slow-discharge to keep the transient of the circuit minimum. Both of these two peak stretchers are described and the experiment results are photographically recorded.

DW-MRI of liver lesions: Can a single ADC-value represent the entire lesion?

International Nuclear Information System (INIS)

Schmid-Tannwald, C.; Dahi, F.; Jiang, Y.; Ivancevic, M.K.; Rist, C.; Sethi, I.; Oommen, J.; Oto, A.

2014-01-01

Aim: To evaluate whether focal liver lesions (FLLs) exhibit a homogeneous appearance on apparent diffusion coefficient (ADC) maps and whether there is inter-section variation in the calculated ADC values of FLLs (inter-section range). Materials and methods: Eighty-eight patients with 128 FLLs (70 benign, 58 malignant) who underwent abdominal magnetic resonance imaging (MRI) including diffusion-weighted (DW)-MRI were included. Two observers evaluated variation of signal intensity of each FLL within each ADC map image (intra-section) and among different ADC map images through the lesion (inter-section). ADC values of each FLL and neighbouring liver parenchyma were measured on all sections. The inter-section range of FLLs was compared with the neighbouring liver parenchyma. Results: Intra-section inhomogeneity was noted in 39.8% (97/244 sections) and 38.9% (95/244) of benign lesions, and 61% (114/187 sections) and 61.5% (115/187) of malignant lesions, by observer 1 and observer 2, respectively. Inter-section inhomogeneity was noted in 25.7% (18/70) and 27.1% (19/70) of benign lesions, and 51.7% (30/58) and 50% (29/58) of malignant lesions, by observer 1 and observer 2, respectively. The inter-section range for both benign (0.28 × 10 −3  mm²/s) and malignant (0.25 × 10 −3  mm²/s) FLLs were significantly greater than that of liver parenchyma surrounding benign (0.16 × 10 −3  mm²/s, p < 0.001) and malignant (0.14 × 10 −3  mm²/s, p = 0.01) FLLs. Conclusion: Due to intra-/inter-section variations in ADC values of benign and malignant FLLs, a single ADC value may not reliably represent the entire lesion

Volterra Filtering for ADC Error Correction

Directory of Open Access Journals (Sweden)

J. Saliga

2001-09-01

Full Text Available Dynamic non-linearity of analog-to-digital converters (ADCcontributes significantly to the distortion of digitized signals. Thispaper introduces a new effective method for compensation such adistortion based on application of Volterra filtering. Considering ana-priori error model of ADC allows finding an efficient inverseVolterra model for error correction. Efficiency of proposed method isdemonstrated on experimental results.

High speed graphic program on a personal computer and its utilization in JIPP T-IIU online data-processing system

International Nuclear Information System (INIS)

Taniguchi, Yoshiyuki; Noda, Nobuaki; Sasao, Mamiko; Sato, Masahiro

1986-01-01

A high speed graphic program was developed on a personal computer PC9801. Using this program, one can draw a waveform of successive 16 bit-integer data, such as obtained by analog-to-digital convertor. The program is written by the machine language and has a form of a subroutine program which can be called from main programs under N 88 BASIC. The time for drawing one waveform is 4 ms, which is two orders faster than the time with standard graphic routines of BASIC interpreter. This program is very convenient for the real-time display of plasma-monitoring raw data, such as plasma current, loop voltage, rf power etc. in tokamak experiments. This program has been utilized in JIPP T-IIU experiments and enables to display data of 8 channel ADC within a few seconds before the system transmits the data from CAMAC to the computer center of the institute. The program and its utilization are presented. (author)

A fast ADC interface with data reduction facilities for multi-parameter experiments in nuclear physics

International Nuclear Information System (INIS)

Liebl, W.; Franz, N.; Ziegler, G.

1982-01-01

A modular ADC interface system for multi-parameter experiments with single NIM ADCs is described. 16 fast ADCs are handled by CAMAC modules and data buses in order to build up a sophisticated hardware system which is able to take coincidence data and singles spectra in parallel. The coincidence logic is handled by one of the interface modules; the interface allows online data reduction. The further expansion of the system will be discussed. (orig.)

A FASTBUS flash ADC system for the Mark II vertex chamber

Energy Technology Data Exchange (ETDEWEB)

Barker, L.

1988-10-01

This is a description of a flash ADC system built for the Mark II experiment at the Stanford Linear Accelerator Center (SLAC). This system was designed for use in the experiment's vertex chamber where signals could occur over a relatively long time, approximately 10 microseconds. This long time, coupled with fast cable amplifiers, necessitated an alternate design approach than was used with a dE/dX FASTBUS flash ADC design. 1 ref., 6 figs.

A 10-bit 120-MS/s pipelined ADC with improved switch and layout scaling strategy

International Nuclear Information System (INIS)

Zhou Jia; Xu Lili; Li Fule; Wang Zhihua

2015-01-01

A 10 bit, 120 MS/s two-channel pipelined analog-to digital converter (ADC) is presented. The ADC is featured with improved switch by using the body effect to improve its conduction performance. A scaling down strategy is proposed to get more efficiency in the OTAs layout design. Implemented in a 0.18-μm CMOS technology, the ADC's prototype occupied an area of 2.05 × 1.83 mm 2 . With a sampling rate of 120-MS/s and an input of 4.9 MHz, the ADC achieves a spurious-free-dynamic range of 74.32 dB and signal-to-noise-and-distortion ratio of 55.34 dB, while consuming 220-mW/channel at 3-V supply. (paper)

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver.

Science.gov (United States)

Tokgoz, Ozlem; Unlu, Ebru; Unal, Ilker; Serifoglu, Ismail; Oz, Ilker; Aktas, Elif; Caglar, Emrah

2016-03-01

To investigate the use of diffusion weighted magnetic resonance imaging (DWI) and the apparent diffusion coefficient (ADC) values in the diagnosis of hemangioma. The study population consisted of 72 patients with liver masses larger than 1 cm (72 focal lesions). DWI examination with a b value of 600 s/mm2 was carried out for all patients. After DWI examination, an ADC map was created and ADC values were measured for 72 liver masses and normal liver tissue (control group). The average ADC values of normal liver tissue and focal liver lesions, the "cut-off" ADC values, and the diagnostic sensitivity and specificity of the ADC map in diagnosing hemangioma, benign and malignant lesions were researched. Of the 72 liver masses, 51 were benign and 21 were malignant. Benign lesions comprised 38 hemangiomas and 13 simple cysts. Malignant lesions comprised 9 hepatocellular carcinomas, and 12 metastases. The highest ADC values were measured for cysts (3.782±0.53×10(-3) mm(2)/s) and hemangiomas (2.705±0.63×10(-3) mm(2)/s). The average ADC value of hemangiomas was significantly higher than malignant lesions and the normal control group (p<0.001). The average ADC value of cysts were significantly higher when compared to hemangiomas and normal control group (p<0.001). To distinguish hemangiomas from malignant liver lesions, the "cut-off" ADC value of 1.800×10(-3) mm(2)/s had a sensitivity of 97.4% and a specificity of 90.9%. To distinguish hemangioma from normal liver parenchyma the "cut-off" value of 1.858×10(-3) mm(2)/s had a sensitivity of 97.4% and a specificity of 95.7%. To distinguish benign liver lesions from malignant liver lesions the "cut-off" value of 1.800×10(-3) mm(2)/s had a sensitivity of 96.1% and a specificity of 90.0%. DWI and quantitative measurement of ADC values can be used in differential diagnosis of benign and malignant liver lesions and also in the diagnosis and differentiation of hemangiomas. When dynamic examination cannot distinguish cases with

Full-frame, high-speed 3D shape and deformation measurements using stereo-digital image correlation and a single color high-speed camera

Science.gov (United States)

Yu, Liping; Pan, Bing

2017-08-01

Full-frame, high-speed 3D shape and deformation measurement using stereo-digital image correlation (stereo-DIC) technique and a single high-speed color camera is proposed. With the aid of a skillfully designed pseudo stereo-imaging apparatus, color images of a test object surface, composed of blue and red channel images from two different optical paths, are recorded by a high-speed color CMOS camera. The recorded color images can be separated into red and blue channel sub-images using a simple but effective color crosstalk correction method. These separated blue and red channel sub-images are processed by regular stereo-DIC method to retrieve full-field 3D shape and deformation on the test object surface. Compared with existing two-camera high-speed stereo-DIC or four-mirror-adapter-assisted singe-camera high-speed stereo-DIC, the proposed single-camera high-speed stereo-DIC technique offers prominent advantages of full-frame measurements using a single high-speed camera but without sacrificing its spatial resolution. Two real experiments, including shape measurement of a curved surface and vibration measurement of a Chinese double-side drum, demonstrated the effectiveness and accuracy of the proposed technique.

ADC common noise correction and zero suppression in the PIBETA detector

International Nuclear Information System (INIS)

Frlez, E.; Pocanic, D.; Ritt, S.

2001-01-01

We describe a simple procedure for reducing Analog-to-Digital Converter (ADC) common noise in modular detectors that does not require additional hardware. A method using detector noise groups should work well for modular particle detectors such as segmented electromagnetic calorimeters, plastic scintillator hodoscopes, cathode strip wire chambers, segmented active targets, and the like. We demonstrate a 'second pedestal noise correction' method by comparing representative ADC pedestal spectra for various elements of the PIBETA detector before and after the applied correction

High speed VLSI neural network for high energy physics

NARCIS (Netherlands)

Masa, P.; Masa, P.; Hoen, K.; Hoen, Klaas; Wallinga, Hans

1994-01-01

A CMOS neural network IC is discussed which was designed for very high speed applications. The parallel architecture, analog computing and digital weight storage provides unprecedented computing speed combined with ease of use. The circuit classifies up to 70 dimensional vectors within 20

Performance evaluation of the analogue front-end and ADC prototypes for the Gotthard-II development

Science.gov (United States)

Zhang, J.; Andrä, M.; Barten, R.; Bergamaschi, A.; Brückner, M.; Dinapoli, R.; Fröjdh, E.; Greiffenberg, D.; Lopez-Cuenca, C.; Mezza, D.; Mozzanica, A.; Ramilli, M.; Redford, S.; Ruat, M.; Ruder, C.; Schmitt, B.; Shi, X.; Thattil, D.; Tinti, G.; Turcato, M.; Vetter, S.

2017-12-01

Gotthard-II is a silicon microstrip detector developed for the European X-ray Free-Electron Laser (XFEL.EU). Its potential scientific applications include X-ray absorption/emission spectroscopy, hard X-ray high resolution single-shot spectrometry (HiREX), energy dispersive experiments at 4.5 MHz frame rate, beam diagnostics, as well as veto signal generation for pixel detectors. Gotthard-II uses a silicon microstrip sensor with a pitch of 50 μm or 25 μm and with 1280 or 2560 channels wire-bonded to readout chips (ROCs). In the ROC, an adaptive gain switching pre-amplifier (PRE), a fully differential Correlated-Double-Sampling (CDS) stage, an Analog-to-Digital Converter (ADC) as well as a Static Random-Access Memory (SRAM) capable of storing all the 2700 images in an XFEL.EU bunch train will be implemented. Several prototypes with different designs of the analogue front-end (PRE and CDS) and ADC test structures have been fabricated in UMC-110 nm CMOS technology and their performance has been evaluated. In this paper, the performance of the analogue front-end and ADC will be summarized.

A fast ADC system for silicon μstrips readout

International Nuclear Information System (INIS)

Inzani, P.; Pedrini, D.; Sala, S.

1986-01-01

A new fast ADC module has been designed. It is part of a large readout system for a high resolution vertex detector consisting of 12 silicon microstrip planes with more than 8000 channels. The module employs a set of monolithic gated integrators on input (LeCroy MIQ 401) multiplexed on a single 8 bit FADC (Thompson EFX8308). A built-in preprocessing, performed through look up tables, accomplishes equalization and reduction of the data and makes high level trigger feasible. As an additional feature, fast histogramming of all the channels in parallel has been made possible with an internal memory. Special care has been paid to realize a low cost and low power consumption system

A High-Speed Design of Montgomery Multiplier

Science.gov (United States)

Fan, Yibo; Ikenaga, Takeshi; Goto, Satoshi

With the increase of key length used in public cryptographic algorithms such as RSA and ECC, the speed of Montgomery multiplication becomes a bottleneck. This paper proposes a high speed design of Montgomery multiplier. Firstly, a modified scalable high-radix Montgomery algorithm is proposed to reduce critical path. Secondly, a high-radix clock-saving dataflow is proposed to support high-radix operation and one clock cycle delay in dataflow. Finally, a hardware-reused architecture is proposed to reduce the hardware cost and a parallel radix-16 design of data path is proposed to accelerate the speed. By using HHNEC 0.25μm standard cell library, the implementation results show that the total cost of Montgomery multiplier is 130 KGates, the clock frequency is 180MHz and the throughput of 1024-bit RSA encryption is 352kbps. This design is suitable to be used in high speed RSA or ECC encryption/decryption. As a scalable design, it supports any key-length encryption/decryption up to the size of on-chip memory.

Diffusion-weighted MR imaging and ADC mapping in differentiating benign from malignant thyroid nodules

International Nuclear Information System (INIS)

Khizer, A.T.; Slehria, A.U.R.

2015-01-01

To determine the diagnostic accuracy of Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) mapping in differentiating benign from malignant thyroid nodules by taking histopathology as the gold standard. Study Design:Across-sectional analytical study. Place and Duration of Study: Department of Radiology at Combined Military Hospital (CMH), Lahore, from August 2012 to July 2013. Methodology: Thirty-five patients, who were referred to radiology department of CMH, Lahore, for ultrasound or Fine Needle Aspiration Cytology (FNAC) of thyroid gland, fulfilling the inclusion and exclusion criteria, were included in the study. They were evaluated on 1.5 Tesla MRI machine with T1- and T2-weighted imaging as well as fat-suppressed technique. DWI was done using b-values of 0 and 1000 s/mm2 and ADC values were calculated for the thyroid nodules. All of these patients were subjected to ultrasound guided core biopsy and histopathology results were correlated with ADC values. Results: The benign nodules showed facilitated diffusion while malignant nodules showed restricted diffusion. T-test was used to assess the difference in mean ADC values between benign and malignant nodules. The mean ADC value of the malignant thyroid nodules (0.94 ± 0.16 x 10/sup -3/mm2/s) was significantly lower than that of the benign thyroid nodules (1.93 ±0.13 x 10/sup -3/mm2/s) (p-value < 0.05). ADC value of 1.6 x 10/sup -3/mm2/s was used as a cut-off, for differentiating benign from malignant thyroid nodules. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of DWI and ADC values in differentiating benign from malignant thyroid nodules were 93%, 95%, 93%, 95% and 92.3%, respectively. Conclusion: DWI is a non-invasive diagnostic tool for characterization and differentiation between benign and malignant thyroid nodules. It not only decreases the burden of unnecessary surgeries when pre-operative FNAC and biopsy are inconclusive, but is also helpful in reaching a

A 14-bit 50 MS/s sample-and-hold circuit for pipelined ADC

International Nuclear Information System (INIS)

Yue Sen; Zhao Yiqiang; Pang Ruilong; Sheng Yun

2014-01-01

A high performance sample-and-hold (S/H) circuit used in a pipelined analog-to-digital converter (ADC) is presented. Capacitor flip-around architecture is used in this S/H circuit with a novel gain-boosted differential folded cascode operational transconductance amplifier. A double-bootstrapped switch is designed to improve the performance of the circuit. The circuit is implemented using a 0.18 μm 1P6M CMOS process. Measurement results show that the effective number of bits is 14.03 bits, the spurious free dynamic range is 94.62 dB, the signal to noise and distortion ratio is 86.28 dB, and the total harmonic distortion is −91:84 dB for a 5 MHz input signal with 50 MS/s sampling rate. A pipeline ADC with the designed S/H circuit has been implemented. (semiconductor integrated circuits)

High-speed and high-fidelity system and method for collecting network traffic

Science.gov (United States)

Weigle, Eric H [Los Alamos, NM

2010-08-24

A system is provided for the high-speed and high-fidelity collection of network traffic. The system can collect traffic at gigabit-per-second (Gbps) speeds, scale to terabit-per-second (Tbps) speeds, and support additional functions such as real-time network intrusion detection. The present system uses a dedicated operating system for traffic collection to maximize efficiency, scalability, and performance. A scalable infrastructure and apparatus for the present system is provided by splitting the work performed on one host onto multiple hosts. The present system simultaneously addresses the issues of scalability, performance, cost, and adaptability with respect to network monitoring, collection, and other network tasks. In addition to high-speed and high-fidelity network collection, the present system provides a flexible infrastructure to perform virtually any function at high speeds such as real-time network intrusion detection and wide-area network emulation for research purposes.

Whole lesion histogram analysis of meningiomas derived from ADC values. Correlation with several cellularity parameters, proliferation index KI 67, nucleic content, and membrane permeability.

Science.gov (United States)

Surov, Alexey; Hamerla, Gordian; Meyer, Hans Jonas; Winter, Karsten; Schob, Stefan; Fiedler, Eckhard

2018-09-01

To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADC mean , ADC max , ADC min , ADC median , ADC mode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy. All measures were performed by two radiologists. Proliferation index KI 67, minimal, maximal and mean cell count, total nucleic area, and expression of water channel aquaporin 4 (AQP4) were estimated. Spearman's correlation coefficient was used to analyze associations between investigated parameters. A perfect interobserver agreement for all ADC values (0.84-0.97) was identified. All ADC values correlated inversely with tumor cellularity with the strongest correlation between P10, P25 and mean cell count (-0.558). KI 67 correlated inversely with all ADC values except ADC min . ADC parameters did not correlate with total nucleic area. All ADC values correlated statistically significant with expression of AQP4. ADC histogram analysis is a valid method with an excellent interobserver agreement. Cellularity parameters and proliferation potential are associated with different ADC values. Membrane permeability may play a greater role for water diffusion than cell count and proliferation activity. Copyright © 2018 Elsevier Inc. All rights reserved.

A 2-GS/s 6-bit self-calibrated flash ADC

Energy Technology Data Exchange (ETDEWEB)

Zhang Youtao; Chen Chen [National Key Laboratory of Monolithic Integrated Circuits and Modules, Nanjing Electronic Devices Institute, Nanjing 210016 (China); Li Xiaopeng; Zhang Min; Liu Ao, E-mail: zhangyt@nedc-ic.co [Nanjing Electronic Devices Institute, Nanjing 210016 (China)

2010-09-15

A single channel 2-GS/s 6-bit ADC with cascade resistive averaging and self foreground calibration is demonstrated in 0.18-{mu}m CMOS. The calibration method based on DAC trimming improves the linearity and dynamic performance further. The peak DNL and INL are measured as 0.34 and 0.22 LSB, respectively. The SNDR and SFDR have achieved 36.5 and 45.9 dB, respectively, with 1.22 MHz input signal and 2 GS/s. The proposed ADC, including on-chip track-and-hold amplifiers and clock buffers, consumes 570 mW from a single 1.8 V supply while operating at 2 GS/s. (semiconductor integrated circuits)

Potential scenarios of concern for high speed rail operations

Science.gov (United States)

2011-03-16

Currently, multiple operating authorities are proposing the : introduction of high-speed rail service in the United States. : While high-speed rail service shares a number of basic : principles with conventional-speed rail service, the operational : ...

Experimental demonstration of a real-time high-throughput digital DC blocker for compensating ADC imperfections in optical fast-OFDM receivers.

Science.gov (United States)

Zhang, Lu; Ouyang, Xing; Shao, Xiaopeng; Zhao, Jian

2016-06-27

Performance degradation induced by the DC components at the output of real-time analogue-to-digital converter (ADC) is experimentally investigated for optical fast-OFDM receiver. To compensate this degradation, register transfer level (RTL) circuits for real-time digital DC blocker with 20GS/s throughput are proposed and implemented in field programmable gate array (FPGA). The performance of the proposed real-time digital DC blocker is experimentally investigated in a 15Gb/s optical fast-OFDM system with intensity modulation and direct detection over 40 km standard single-mode fibre. The results show that the fixed-point DC blocker has negligible performance penalty compared to the offline floating point one, and can overcome the error floor of the fast OFDM receiver caused by the DC components from the real-time ADC output.

CAMAC interface module for PACE ADC system

Energy Technology Data Exchange (ETDEWEB)

Dalton, C G; Mischke, R E [Los Alamos Scientific Lab., N.Mex. (USA); Scott, D T

1977-03-15

This report describes a CAMAC module designed to buffer and transfer data from the Tennelec multiplexed ADC system called PACE to a computer. It can be operated in either of two modes: as an eight-deep, first-in-first-out (FIFO) circular buffer, or in channel mode with a single buffer reserved for each PACE channel.

The appearance of ADCs in the non-affected areas of the patients with MELAS

International Nuclear Information System (INIS)

Liu, Zhenghua; Liu, Xiwei; Hui, Lihong; Xie, Sheng; Xiao, Jiangxi; Jiang, Xuexiang; Zhao, Danhua; Wang, Xiaoying

2011-01-01

The exact mechanism of the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remain unclear. Diffusion-weighted imaging (DWI) is a magnetic resonance (MR) imaging technique for studying the pathophysiologic change of the MELAS. The purpose of the study is to see whether the apparent diffusion coefficient (ADC) of MELAS in the non-affected areas is different from the ADC of the normal subjects and to speculate the pathophysiological mechanisms of the MELAS. Sixteen cases of MELAS were retrospectively analyzed. Thirty healthy subjects were chosen to constitute the control group. All of them were performed on the 3.0T whole-body MR scanner with axial view T2 fluid attenuated inversion recovery (flair), T2-weighted imaging, T1flair, and DWI. An ADC map was reconstructed in the workstation. Two to five regions of interest were put in the non-affected frontal lobe and basal ganglia. All data took statistical analysis. There were significant differences between the ADC of the patients with MELAS and the controls in the non-affected areas, including the superior frontal gyrus, precentral gyrus, corpus striatum, thalamus, and white matter of the semi-oval centrum. ADCs in the non-affected areas of the patients with MELAS are higher than those of the normal subjects. Pathological changes take place in the non-affected areas of the patients with MELAS. (orig.)

The appearance of ADCs in the non-affected areas of the patients with MELAS

Energy Technology Data Exchange (ETDEWEB)

Liu, Zhenghua; Liu, Xiwei; Hui, Lihong; Xie, Sheng; Xiao, Jiangxi; Jiang, Xuexiang [Peking University First Hospital, Center for Functional Imaging, Peking University, The Department of Radiology, Beijing (China); Zhao, Danhua [Peking University First Hospital, The Department of Neurology, Beijing (China); Wang, Xiaoying [Peking University First Hospital, Center for Functional Imaging, Peking University, The Department of Radiology, Beijing (China); Peking University First Hospital, The Department of Radiology, 8, Xishiku Street, Xicheng District, Beijing (China)

2011-04-15

The exact mechanism of the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remain unclear. Diffusion-weighted imaging (DWI) is a magnetic resonance (MR) imaging technique for studying the pathophysiologic change of the MELAS. The purpose of the study is to see whether the apparent diffusion coefficient (ADC) of MELAS in the non-affected areas is different from the ADC of the normal subjects and to speculate the pathophysiological mechanisms of the MELAS. Sixteen cases of MELAS were retrospectively analyzed. Thirty healthy subjects were chosen to constitute the control group. All of them were performed on the 3.0T whole-body MR scanner with axial view T2 fluid attenuated inversion recovery (flair), T2-weighted imaging, T1flair, and DWI. An ADC map was reconstructed in the workstation. Two to five regions of interest were put in the non-affected frontal lobe and basal ganglia. All data took statistical analysis. There were significant differences between the ADC of the patients with MELAS and the controls in the non-affected areas, including the superior frontal gyrus, precentral gyrus, corpus striatum, thalamus, and white matter of the semi-oval centrum. ADCs in the non-affected areas of the patients with MELAS are higher than those of the normal subjects. Pathological changes take place in the non-affected areas of the patients with MELAS. (orig.)

High-Speed Non-Volatile Optical Memory: Achievements and Challenges

Directory of Open Access Journals (Sweden)

Vadym Zayets

2017-01-01

Full Text Available We have proposed, fabricated, and studied a new design of a high-speed optical non-volatile memory. The recoding mechanism of the proposed memory utilizes a magnetization reversal of a nanomagnet by a spin-polarized photocurrent. It was shown experimentally that the operational speed of this memory may be extremely fast above 1 TBit/s. The challenges to realize both a high-speed recording and a high-speed reading are discussed. The memory is compact, integratable, and compatible with present semiconductor technology. If realized, it will advance data processing and computing technology towards a faster operation speed.

Achievable ADC Performance by Postcorrection Utilizing Dynamic Modeling of the Integral Nonlinearity

Directory of Open Access Journals (Sweden)

Peter Händel

2008-03-01

Full Text Available There is a need for a universal dynamic model of analog-to-digital converters (ADC’s aimed for postcorrection. However, it is complicated to fully describe the properties of an ADC by a single model. An alternative is to split up the ADC model in different components, where each component has unique properties. In this paper, a model based on three components is used, and a performance analysis for each component is presented. Each component can be postcorrected individually and by the method that best suits the application. The purpose of postcorrection of an ADC is to improve the performance. Hence, for each component, expressions for the potential improvement have been developed. The measures of performance are total harmonic distortion (THD and signal to noise and distortion (SINAD, and to some extent spurious-free dynamic range (SFDR.

High speed laser tomography system

Science.gov (United States)

Samsonov, D.; Elsaesser, A.; Edwards, A.; Thomas, H. M.; Morfill, G. E.

2008-03-01

A high speed laser tomography system was developed capable of acquiring three-dimensional (3D) images of optically thin clouds of moving micron-sized particles. It operates by parallel-shifting an illuminating laser sheet with a pair of galvanometer-driven mirrors and synchronously recording two-dimensional (2D) images of thin slices of the imaged volume. The maximum scanning speed achieved was 120000slices/s, sequences of 24 volume scans (up to 256 slices each) have been obtained. The 2D slices were stacked to form 3D images of the volume, then the positions of the particles were identified and followed in the consecutive scans. The system was used to image a complex plasma with particles moving at speeds up to cm/s.

A Historical Review of High Speed Metal Forming

OpenAIRE

Zittel, G.

2010-01-01

This paper will present a Historical Review of High Speed Metal Forming beginning with the first thought of forming metal by using an electromagnetic impulse to today, whereby High Speed Metal Forming is an accepted production process. Although this paper will briefly cover the basic physics of the process, it will not dwell on it. It will rather show how the industrial acceptance of High Speed Metal Forming is tightly connected to the knowledge acquired from many applications studies. These ...

High-speed photography. Technique and evolution

International Nuclear Information System (INIS)

Sanchez-Tembleque, R.

1981-01-01

It is intended to present some general considerations about ''Higg-speed photography'' as a tool of work common in mos research laboratories in the world. ''High-speed photography'' relies on the principles of photography of actions, that change rapidly with the time. The evolution of this technique goes along with the discovering of new phenomena in wich higher speeds are involved. At present is normal to deal with changing rates involving picoseconds times (10 -12 s) and new developments on the field of femtosecond (10 -15 s) theoretically are contemplated. (author)

Review of High-Speed Fiber Optic Grating Sensors Systems

Energy Technology Data Exchange (ETDEWEB)

Udd, E; Benterou, J; May, C; Mihailov, S J; Lu, P

2010-03-24

Fiber grating sensors can be used to support a wide variety of high speed measurement applications. This includes measurements of vibrations on bridges, traffic monitoring on freeways, ultrasonic detection to support non-destructive tests on metal plates and providing details of detonation events. This paper provides a brief overview of some of the techniques that have been used to support high speed measurements using fiber grating sensors over frequency ranges from 10s of kHz, to MHZ and finally toward frequencies approaching the GHz regime. Very early in the development of fiber grating sensor systems it was realized that a high speed fiber grating sensor system could be realized by placing an optical filter that might be a fiber grating in front of a detector so that spectral changes in the reflection from a fiber grating were amplitude modulated. In principal the only limitation on this type of system involved the speed of the output detector which with the development of high speed communication links moved from the regime of 10s of MHz toward 10s of GHz. The earliest deployed systems involved civil structures including measurements of the strain fields on composite utility poles and missile bodies during break tests, bridges and freeways. This was followed by a series of developments that included high speed fiber grating sensors to support nondestructive testing via ultrasonic wave detection, high speed machining and monitoring ship hulls. Each of these applications involved monitoring mechanical motion of structures and thus interest was in speeds up to a few 10s of MHz. Most recently there has been interest in using fiber grating to monitor the very high speed events such as detonations and this has led to utilization of fiber gratings that are consumed during an event that may require detection speeds of hundreds of MHz and in the future multiple GHz.

Diffusion Weighted Imaging of the Uterus: Regional ADC Variation with Oral Contraceptive Usage and Comparison with Cervical Cancer

Energy Technology Data Exchange (ETDEWEB)

Messiou, Christina; Morgan, Veronica A.; Silva, Sonali S. de; Souza, Nandita M. de (Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Ind, Thomas E. (Dept. of Gynaecology and Obstetrics, St George' s Hospital NHS Trust, London (United Kingdom))

2009-07-15

Background: There is growing interest in diffusion weighted magnetic resonance imaging (MRI) of cervical carcinoma but normal uterine appearances and effects of the oral contraceptive pill (OCP) have not been described. Purpose: To establish apparent diffusion coefficient (ADC) values for normal regions of uterus, determine the effect of the OCP on these values, and compare them with ADCs from cervical cancer. Material and Methods: Twenty-seven premenopausal women (19 taking the OCP) with cervical intraepithelial neoplasia (CIN) were studied with T2W and diffusion weighted MRI (DW-MRI). Regions of interest were drawn on ADC maps by visual matching with T2W images on different zones of the uterus and values compared between women not taking and taking the OCp.A further group of 25 women with clinically obvious tumors of the cervix were also studied with T2W and DW-MRI and ADC values of tumor were compared with ADC values of cervical epithelium and stroma. Results: The ADC values of adjacent zones of the uterus and cervix were significantly different from one another (P<0.001). The junctional zone was seen as a band of restricted diffusion between endometrium and outer myometrium. The ADC value of the junctional zone of the uterus was significantly greater (P<0.001) in patients taking the OCP than those patients not taking the OCp.There was no significant affect of the OCP on the ADC values of other uterine zones. Conclusion: The zonal anatomy of the uterus is well demonstrated by DW-MRI with hormonal effects secondary to the OCP affecting junctional zone alone. ADC of cervical tumor is significantly different to cervical epithelium and stroma indicating a role in cervical cancer detection and local staging

Diffusion Weighted Imaging of the Uterus: Regional ADC Variation with Oral Contraceptive Usage and Comparison with Cervical Cancer

International Nuclear Information System (INIS)

Messiou, Christina; Morgan, Veronica A.; Silva, Sonali S. de; Souza, Nandita M. de; Ind, Thomas E.

2009-01-01

Background: There is growing interest in diffusion weighted magnetic resonance imaging (MRI) of cervical carcinoma but normal uterine appearances and effects of the oral contraceptive pill (OCP) have not been described. Purpose: To establish apparent diffusion coefficient (ADC) values for normal regions of uterus, determine the effect of the OCP on these values, and compare them with ADCs from cervical cancer. Material and Methods: Twenty-seven premenopausal women (19 taking the OCP) with cervical intraepithelial neoplasia (CIN) were studied with T2W and diffusion weighted MRI (DW-MRI). Regions of interest were drawn on ADC maps by visual matching with T2W images on different zones of the uterus and values compared between women not taking and taking the OCp.A further group of 25 women with clinically obvious tumors of the cervix were also studied with T2W and DW-MRI and ADC values of tumor were compared with ADC values of cervical epithelium and stroma. Results: The ADC values of adjacent zones of the uterus and cervix were significantly different from one another (P<0.001). The junctional zone was seen as a band of restricted diffusion between endometrium and outer myometrium. The ADC value of the junctional zone of the uterus was significantly greater (P<0.001) in patients taking the OCP than those patients not taking the OCp.There was no significant affect of the OCP on the ADC values of other uterine zones. Conclusion: The zonal anatomy of the uterus is well demonstrated by DW-MRI with hormonal effects secondary to the OCP affecting junctional zone alone. ADC of cervical tumor is significantly different to cervical epithelium and stroma indicating a role in cervical cancer detection and local staging

Conversion of ADC pulse heights into MIP units (NUMASS test data, September 1991)

International Nuclear Information System (INIS)

Zhang, Q.P.

1993-04-01

ADC calibration is an important part of the data analysis in particle physics. Data analysis of ADC pulse heights is based on a physical unit which is called MIP (most probable energy loss of Minimum Ionization Particles). This paper describes the ADC calibration work for the September 1991 NUMASS test data, which were produced at CERN at the SPS facility. The Vavilov function is used to fit the energy loss distributions of minimum ionizing particles traversing the time of flight scintillators embedded in the uranium scintillator calorimeter. It is assumed that the energy loss distribution is the same for identical scintillators and the value at the peak of these distributions is used, i.e., the most probable energy loss, as a physical unit to derive the gains of the individual readout channels

High-Speed Videography Instrumentation And Procedures

Science.gov (United States)

Miller, C. E.

1982-02-01

High-speed videography has been an electronic analog of low-speed film cameras, but having the advantages of instant-replay and simplicity of operation. Recent advances have pushed frame-rates into the realm of the rotating prism camera. Some characteristics of videography systems are discussed in conjunction with applications in sports analysis, and with sports equipment testing.

A 10-bit 50-MS/s subsampling pipelined ADC based on SMDAC and opamp sharing

Energy Technology Data Exchange (ETDEWEB)

Chen Lijie; Zhou Yumei; Wei Baoyue, E-mail: frankdhz@yahoo.com.cn [Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029 (China)

2010-11-15

This paper describes a 10-bit, 50-MS/s pipelined A/D converter (ADC) with proposed area- and power-efficient architecture. The conventional dedicated sample-hold-amplifier (SHA) is eliminated and the matching requirement between the first multiplying digital-to-analog converter (MDAC) and sub-ADC is also avoided by using the SHA merged with the first MDAC (SMDAC) architecture, which features low power and stabilization. Further reduction of power and area is achieved by sharing an opamp between two successive pipelined stages, in which the effect of opamp offset and crosstalk between stages is decreased. So the 10-bit pipelined ADC is realized using just four opamps. The ADC demonstrates a maximum signal-to-noise distortion ratio and spurious free dynamic range of 52.67 dB and 59.44 dB, respectively, with a Nyquist input at full sampling rate. Constant dynamic performance for input frequencies up to 49.7 MHz, which is the twofold Nyquist rate, is achieved at 50 MS/s. The ADC prototype only occupies an active area of 1.81 mm{sup 2} in a 0.35 {mu}m CMOS process, and consumes 133 mW when sampling at 50 MHz from a 3.3-V power supply.

Integrated computer network high-speed parallel interface

International Nuclear Information System (INIS)

Frank, R.B.

1979-03-01

As the number and variety of computers within Los Alamos Scientific Laboratory's Central Computer Facility grows, the need for a standard, high-speed intercomputer interface has become more apparent. This report details the development of a High-Speed Parallel Interface from conceptual through implementation stages to meet current and future needs for large-scle network computing within the Integrated Computer Network. 4 figures

High-speed and intercity passenger rail testing strategy.

Science.gov (United States)

2013-05-01

This high-speed and intercity passenger rail (HSIPR) testing strategy addresses the requirements for testing of high-speed train sets and technology before introduction to the North American railroad system. The report documents the results of a surv...

Application of high-speed photography to hydrodynamic instability research

International Nuclear Information System (INIS)

Chang Lihua; Li Zuoyou; Xiao Zhengfei; Zou Liyong; Liu Jinhong; Xiong Xueshi

2012-01-01

High-speed photography is used to study the Rayleigh-Taylor instability of air-water interface driven by high- pressure exploding gas. Clear images illustrating the instability are obtained, along with the air bubble peak speed and turbulent mixing speed. The RM (Richtmyer-Meshkov) instability of air/SF 6 interface driven by shock wave is also researched by using high-speed Schlieren technique on the horizontal shock tube and primary experimental results are obtained, which show the change of the turbulent mixing region clearly. (authors)

Development of high-speed video cameras

Science.gov (United States)

Etoh, Takeharu G.; Takehara, Kohsei; Okinaka, Tomoo; Takano, Yasuhide; Ruckelshausen, Arno; Poggemann, Dirk

2001-04-01

Presented in this paper is an outline of the R and D activities on high-speed video cameras, which have been done in Kinki University since more than ten years ago, and are currently proceeded as an international cooperative project with University of Applied Sciences Osnabruck and other organizations. Extensive marketing researches have been done, (1) on user's requirements on high-speed multi-framing and video cameras by questionnaires and hearings, and (2) on current availability of the cameras of this sort by search of journals and websites. Both of them support necessity of development of a high-speed video camera of more than 1 million fps. A video camera of 4,500 fps with parallel readout was developed in 1991. A video camera with triple sensors was developed in 1996. The sensor is the same one as developed for the previous camera. The frame rate is 50 million fps for triple-framing and 4,500 fps for triple-light-wave framing, including color image capturing. Idea on a video camera of 1 million fps with an ISIS, In-situ Storage Image Sensor, was proposed in 1993 at first, and has been continuously improved. A test sensor was developed in early 2000, and successfully captured images at 62,500 fps. Currently, design of a prototype ISIS is going on, and, hopefully, will be fabricated in near future. Epoch-making cameras in history of development of high-speed video cameras by other persons are also briefly reviewed.

High-speed AFM of human chromosomes in liquid

Energy Technology Data Exchange (ETDEWEB)

Picco, L M; Dunton, P G; Ulcinas, A; Engledew, D J; Miles, M J [H H Wills Physics Laboratory and IRC in Nanotechnology, University of Bristol, Tyndall Avenue, Bristol BS8 1TL (United Kingdom); Hoshi, O; Ushiki, T [Division of Microscopic Anatomy and Bio-Imaging, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-Dori 1, Niigata, 951-8150 (Japan)], E-mail: m.j.miles@bristol.ac.uk

2008-09-24

Further developments of the previously reported high-speed contact-mode AFM are described. The technique is applied to the imaging of human chromosomes at video rate both in air and in water. These are the largest structures to have been imaged with high-speed AFM and the first imaging in liquid to be reported. A possible mechanism that allows such high-speed contact-mode imaging without significant damage to the sample is discussed in the context of the velocity dependence of the measured lateral force on the AFM tip.

Characterizing speed-independence of high-level designs

DEFF Research Database (Denmark)

Kishinevsky, Michael; Staunstrup, Jørgen

1994-01-01

This paper characterizes the speed-independence of high-level designs. The characterization is a condition on the design description ensuring that the behavior of the design is independent of the speeds of its components. The behavior of a circuit is modeled as a transition system, that allows data...... types, and internal as well as external non-determinism. This makes it possible to verify the speed-independence of a design without providing an explicit realization of the environment. The verification can be done mechanically. A number of experimental designs have been verified including a speed-independent...

Development of ultra high speed photographic system using high repetition rate visible laser

International Nuclear Information System (INIS)

Lee, Jong Min; Cha, Byung Hun; Kim, Sung Ho; Kim, Jung Bog; Lim, Chang Hwan; Cha, Hyung Ki; Song, Kyu Seok; Lee, Byung Deok; Rhi, Jong Hoon; Baik, Dae Hyun; Han, Jae Min; Rho, Si Pyo; Lee, Byung Cheol; Jeong, Do Yung; Choi, An Seong; Jeong, Chan Ik; Park, Dae Ung; Jeong, Sung Min; Lee, Sang Kil; Kim, Heon Jun; Jang, Rae gak; Jo, Do Hun; Park, Min Young

1992-12-01

The goal of this project is to develop and commercialize a high speed photographic system equipped with a high repetition rate visible laser. The developed system provides the characteristics of high time resolution and large number of frames. The system consists of 10 W air cooled CVL or a 30 W water cooled CVL, a rotating drum-type high speed camera with the framing rate of 35,000 fps, and a automatic control device. The system has the performance of 10 nsec time resolution, 35,000 fps framing rate, and 250 picture frames. The high speed photographic systems are widely applied to the fields such as high-efficient engine development, high-speed vibration analysis, shock wave propagation study, flow visualization analysis, weapon development, etc. (Author)

Design and implementation of an MCA card with double ADC for nuclear radiation analysis

International Nuclear Information System (INIS)

Razanabololona, V.H.

2001-01-01

The rapid development of technology has triggered several interesting trends in nuclear instrumentation. In particular, the introduction of add-on cards that can serve as multichannel analyzer and offer adequate performance for most of the nuclear applications. The purpose of this thesis has been the design of a multichannel analyser inserted into microcomputer. The originality of this prototype MCA card with its innovative concept is the use of two analog digital converters or ADC of which the objective is to reduce to minima the lost of pulses during the acquisition and the signals processing. The first ADC works as the main converter (or master) and the second ADC the slave converter. The first ADC begins the first signals acquisition, while it will be busy for the processing, the second ADC continues the acquisition, thus there will be no lost pulses or precisely lost of pulses will be reduced to minima.The three main points for a multichannel analyzer will be studied such a the pile-up, the differential non-linearity or 'DNL' and the dead time. In the first part of this thesis the function of the MCA has been described and the different roles of the composed modules have been developed. In the second part, spectra analysis has been done with the MCA prototype as well the comparison with other MCAs such as MCAs S100, TISA, MCA35+, and the Inspector. [fr

Quantitative evaluation of bone metastases from prostate cancer with simultaneous [18F] choline PET/MRI. Combined SUV and ADC analysis

International Nuclear Information System (INIS)

Wetter, A.; Lipponer, C.; Nensa, F.; Schlosser, T.W.; Lauenstein, T.C.; Heusch, P.; Ruebben, H.; Poeppel, T.D.; Nagarajah, J.

2014-01-01

To quantitatively analyze bone metastases from prostate cancer and correlate the apparent diffusion coefficients (ADCs) and standardized uptake values (SUVs). Fifty-five patients with biopsy-proven prostate cancer or suspected recurrent prostate cancer were examined with simultaneous [ 18 F] choline Positron emission tomography (PET)/MRI at 3 T. In 11 patients, thirty-two PET-positive bone lesions could be identified that were located in the field-of-view of the Diffusion weighted imaging-sequence. Region-of-interest and volume-of-interest analyses were performed to measure the mean and minimal ADCs and to assess maximum and mean SUVs of every bone lesion. Correlations between maximum and mean SUVs and mean and minimal ADCs were calculated. The SUV max of all lesions was 5.5 ± 3.1 (mean ± SD). The SUV mean was 1.8 ± 0.9. The mean ADC (ADC mean ) of all lesions was 0.67 ± 0.13 x 10 -3 mm 2 /s. The minimal ADC (ADC min ) of all lesions was 0.56 ± 0.14 x 10 -3 mm 2 /s. There was a moderate but significant inverse correlation of SUV max vs. ADC mean with a correlation coefficient of -0.4 (p=0.02). There was also a significant inverse correlation of SUV max vs. ADC min with r=-0.41 (p=0.02). Our initial results demonstrate a moderate but significant inverse correlation between increased choline metabolism and ADC values of bone metastases from prostate cancer. Further research on a multimodality approach using simultaneous PET/MRI in bone metastasis of prostate cancer seems to be justified. (author)

Brain development during the first year of life. Quantitative assessment with ADC imaging

International Nuclear Information System (INIS)

Okuda, Yasuyuki

1994-01-01

Brain development during the first year of life was assessed quantitatively using apparent diffusion coefficient (ADC) images constructed from diffusion-weighted MR image data. The imaging plane was coronal at the section of the pons. The cerebral peduncle, internal capsule, corona radiata, superior longitudinal fasciculus and thalamus were selected for evaluation of their ADC values. A diffusion sensitive gradient was added in the anteroposterior direction. Thus the orientation of nerve fibers in the cerebral peduncle, internal capsule and corona radiata was perpendicular to it, and that in the superior longitudinal fasciculus was parallel to it. In neonates, the cerebral peduncle and internal capsule, having been moderately myelinated at birth, showed the slowest diffusion. The corona radiata and superior longitudinal fasciculus, having been unmyelinated at birth, showed the fastest diffusion. The thalamus had intermediate diffusion. These neonatal diffusions tended to be promptly restricted within the first five months, followed by additional slight restriction thereafter. ADC values in the first year were significantly reduced in all regions compared with those in the neonatal period, particularly in the corona radiata and thalamus. This study showed that ADC analysis can estimate normal brain development in detail and might be useful for investigating various neonatal brain diseases. (author)

Minimum Plate Thickness in High-Speed Craft

DEFF Research Database (Denmark)

Pedersen, Preben Terndrup; Zhang, Shengming

1998-01-01

The minimum plate thickness requirements specified by the classification societies for high-speed craft are supposed to ensure adequate resistance to impact loads such as collision with floating objects and objects falling on the deck. The paper presents analytical methods of describing such impact...... phenomena and proposes performance requirements instead of thickness requirements for hull panels in high-speed craft made of different building materials....

The large scale and long term evolution of the solar wind speed distribution and high speed streams

International Nuclear Information System (INIS)

Intriligator, D.S.

1977-01-01

The spatial and temporal evolution of the solar wind speed distribution and of high speed streams in the solar wind are examined. Comparisons of the solar wind streaming speeds measured at Earth, Pioneer 11, and Pioneer 10 indicate that between 1 AU and 6.4 AU the solar wind speed distributions are narrower (i.e. the 95% value minus the 5% value of the solar wind streaming speed is less) at extended heliocentric distances. These observations are consistent with one exchange of momentum in the solar wind between high speed streams and low speed streams as they propagate outward from the Sun. Analyses of solar wind observations at 1 AU from mid 1964 through 1973 confirm the earlier results reported by Intriligator (1974) that there are statistically significant variations in the solar wind in 1968 and 1969, years of solar maximum. High speed stream parameters show that the number of high speed streams in the solar wind in 1968 and 1969 is considerably more than the predicted yearly average, and in 1965 and 1972 less. Histograms of solar wind speed from 1964 through 1973 indicate that in 1968 there was the highest percentage of elevated solar wind speeds and in 1965 and 1972 the lowest. Studies by others also confirm these results although the respective authors did not indicate this fact. The duration of the streams and the histograms for 1973 imply a shifting in the primary stream source. (Auth.)

Corrected RMS Error and Effective Number of Bits for Sinewave ADC Tests

International Nuclear Information System (INIS)

Jerome J. Blair

2002-01-01

A new definition is proposed for the effective number of bits of an ADC. This definition removes the variation in the calculated effective bits when the amplitude and offset of the sinewave test signal is slightly varied. This variation is most pronounced when test signals with amplitudes of a small number of code bin widths are applied to very low noise ADC's. The effectiveness of the proposed definition is compared with that of other proposed definitions over a range of signal amplitudes and noise levels

Rat muscle blood flows during high-speed locomotion

International Nuclear Information System (INIS)

Armstrong, R.B.; Laughlin, M.H.

1985-01-01

We previously studied blood flow distribution within and among rat muscles as a function of speed from walking (15 m/min) through galloping (75 m/min) on a motor-driven treadmill. The results showed that muscle blood flows continued to increase as a function of speed through 75 m/min. The purpose of the present study was to have rats run up to maximal treadmill speeds to determine if blood flows in the muscles reach a plateau as a function of running speed over the animals normal range of locomotory speeds. Muscle blood flows were measured with radiolabeled microspheres at 1 min of running at 75, 90, and 105 m/min in male Sprague-Dawley rats. The data indicate that even at these relatively high treadmill speeds there was still no clear evidence of a plateau in blood flow in most of the hindlimb muscles. Flows in most muscles continued to increase as a function of speed. These observed patterns of blood flow vs. running speed may have resulted from the rigorous selection of rats that were capable of performing the high-intensity exercise and thus only be representative of a highly specific population of animals. On the other hand, the data could be interpreted to indicate that the cardiovascular potential during exercise is considerably higher in laboratory rats than has normally been assumed and that inadequate blood flow delivery to the muscles does not serve as a major limitation to their locomotory performance

Real time prediction and correction of ADCS problems in LEO satellites using fuzzy logic

Directory of Open Access Journals (Sweden)

Yassin Mounir Yassin

2017-06-01

Full Text Available This approach is concerned with adapting the operations of attitude determination and control subsystem (ADCS of low earth orbit LEO satellites through analyzing the telemetry readings received by mission control center, and then responding to ADCS off-nominal situations. This can be achieved by sending corrective operational Tele-commands within real time. Our approach is related to the fuzzy membership of off-nominal telemetry readings of corrective actions through a set of fuzzy rules based on understanding the ADCS modes resulted from the satellite telemetry readings. Response in real time gives us a chance to avoid risky situations. The approach is tested on the EgyptSat-1 engineering model, which is our method to simulate the results.

High-Speed Photo-Polarimetry of Magnetic Cataclysmic Variables

Directory of Open Access Journals (Sweden)

S. B. Potter

2015-02-01

Full Text Available I review recent highlights of the SAAO High-speed Photo-POlarimeter (HIPPO on the study of magnetic Cataclysmic Variables. Its high-speed capabilities are demonstrated with example observations made of the intermediate polar NY Lup and the polar IGRJ14536-5522.

Trend on High-speed Power Line Communication Technology

Science.gov (United States)

Ogawa, Osamu

High-speed power line communication (PLC) is useful technology to easily build the communication networks, because construction of new infrastructure is not necessary. In Europe and America, PLC has been used for broadband networks since the beginning of 21th century. In Japan, high-speed PLC was deregulated only indoor usage in 2006. Afterward it has been widely used for home area network, LAN in hotels and school buildings and so on. And recently, PLC is greatly concerned as communication technology for smart grid network. In this paper, the author surveys the high-speed PLC technology and its current status.

A high speed digital noise generator

Science.gov (United States)

Obrien, J.; Gaffney, B.; Liu, B.

In testing of digital signal processing hardware, a high speed pseudo-random noise generator is often required to simulate an input noise source to the hardware. This allows the hardware to be exercised in a manner analogous to actual operating conditions. In certain radar and communication environments, a noise generator operating at speeds in excess of 60 MHz may be required. In this paper, a method of generating high speed pseudo-random numbers from an arbitrarily specified distribution (Gaussian, Log-Normal, etc.) using a transformation from a uniform noise source is described. A noise generator operating at 80 MHz has been constructed. Different distributions can be readily obtained by simply changing the ROM set. The hardware and test results will be described. Using this approach, the generation of pseudo-random sequences with arbitrary distributions at word rates in excess of 200 MHz can be readily achieved.

Compressibility, turbulence and high speed flow

CERN Document Server

Gatski, Thomas B

2013-01-01

Compressibility, Turbulence and High Speed Flow introduces the reader to the field of compressible turbulence and compressible turbulent flows across a broad speed range, through a unique complimentary treatment of both the theoretical foundations and the measurement and analysis tools currently used. The book provides the reader with the necessary background and current trends in the theoretical and experimental aspects of compressible turbulent flows and compressible turbulence. Detailed derivations of the pertinent equations describing the motion of such turbulent flows is provided and an extensive discussion of the various approaches used in predicting both free shear and wall bounded flows is presented. Experimental measurement techniques common to the compressible flow regime are introduced with particular emphasis on the unique challenges presented by high speed flows. Both experimental and numerical simulation work is supplied throughout to provide the reader with an overall perspective of current tre...

High-speed solar wind flow parameters at 1 AU

International Nuclear Information System (INIS)

Feldman, W.C.; Asbridge, J.R.; Bame, S.J.; Gosling, J.T.

1976-01-01

To develop a set of constraints for theories of solar wind high-speed streams, a detailed study was made of the fastest streams observed at 1 AU during the time period spanning March 1971 through July 1974. Streams were accepted for study only if (1) the maximum speed exceeded 650 km s -1 ; (2) effects of stream-stream dynamical interaction on the flow parameters could be safely separated from the intrinsic characteristics of the high-speed regions; (3) the full width at half maximum (FWHM) of the stream when mapped back to 20 solar radii by using a constant speed approximation was greater than 45degree in Carrington longitude; and (4) there were no obvious solar-activity-induced contaminating effects. Nineteen streams during this time interval satisfied these criteria. Average parameters at 1 AU for those portions of these streams above V=650 km s -1 are given.Not only is it not presently known why electrons are significantly cooler than the protons within high-speed regions, but also observed particle fluxes and convected energy fluxes for speed greater than 650 km s -1 are substantially larger than those values predicted by any of the existing theories of solar wind high-speed streams. More work is therefore needed in refining present solar wind models to see whether suitable modifications and/or combinations of existing theories based on reasonable coronal conditions can accommodate the above high-speed flow parameters

California statewide model for high-speed rail

OpenAIRE

Outwater, Maren; Tierney, Kevin; Bradley, Mark; Sall, Elizabeth; Kuppam, Arun; Modugala, Vamsee

2010-01-01

The California High Speed Rail Authority (CHSRA) and the Metropolitan Transportation Commission (MTC) have developed a new statewide model to support evaluation of high-speed rail alternatives in the State of California. This statewide model will also support future planning activities of the California Department of Transportation (Caltrans). The approach to this statewide model explicitly recognizes the unique characteristics of intraregional travel demand and interregional travel demand. A...

Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

Directory of Open Access Journals (Sweden)

Arheden Håkan

2010-09-01

Full Text Available Abstract Background Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the neutrophils from C5a activation before they enter the reperfused area, which could be a mechanistic advantage compared to previous C5a directed reperfusion therapies. We investigated if treatment with ADC-1004, according to a clinically applicable protocol, would reduce infarct size and microvascular obstruction in a large animal myocardial infarct model. Methods In anesthetized pigs (42-53 kg, a percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 minutes, followed by 4 hours of reperfusion. Twenty minutes after balloon inflation the pigs were randomized to an intravenous bolus administration of ADC-1004 (175 mg, n = 8 or saline (9 mg/ml, n = 8. Area at risk (AAR was evaluated by ex vivo SPECT. Infarct size and microvascular obstruction were evaluated by ex vivo MRI. The observers were blinded to the treatment at randomization and analysis. Results ADC-1004 treatment reduced infarct size by 21% (ADC-1004: 58.3 ± 3.4 vs control: 74.1 ± 2.9%AAR, p = 0.007. Microvascular obstruction was similar between the groups (ADC-1004: 2.2 ± 1.2 vs control: 5.3 ± 2.5%AAR, p = 0.23. The mean plasma concentration of ADC-1004 was 83 ± 8 nM at sacrifice. There were no significant differences between the groups with respect to heart rate, mean arterial pressure, cardiac output and blood-gas data. Conclusions ADC-1004 treatment reduces myocardial ischemia-reperfusion injury and represents a novel treatment strategy of myocardial infarct with potential clinical applicability.

Research on Aerodynamic Noise Reduction for High-Speed Trains

OpenAIRE

Zhang, Yadong; Zhang, Jiye; Li, Tian; Zhang, Liang; Zhang, Weihua

2016-01-01

A broadband noise source model based on Lighthill’s acoustic theory was used to perform numerical simulations of the aerodynamic noise sources for a high-speed train. The near-field unsteady flow around a high-speed train was analysed based on a delayed detached-eddy simulation (DDES) using the finite volume method with high-order difference schemes. The far-field aerodynamic noise from a high-speed train was predicted using a computational fluid dynamics (CFD)/Ffowcs Williams-Hawkings (FW-H)...

Nugget Structure Evolution with Rotation Speed for High-Rotation-Speed Friction-Stir-Welded 6061 Aluminum Alloy

Science.gov (United States)

Zhang, H. J.; Wang, M.; Zhu, Z.; Zhang, X.; Yu, T.; Wu, Z. Q.

2018-03-01

High-rotation-speed friction stir welding (HRS-FSW) is a promising technique to reduce the welding loads during FSW and thus facilitates the application of FSW for in situ fabrication and repair. In this study, 6061 aluminum alloy was friction stir welded at high-rotation speeds ranging from 3000 to 7000 rpm at a fixed welding speed of 50 mm/min, and the effects of rotation speed on the nugget zone macro- and microstructures were investigated in detail in order to illuminate the process features. Temperature measurements during HRS-FSW indicated that the peak temperature did not increase consistently with rotation speed; instead, it dropped remarkably at 5000 rpm because of the lowering of material shear stress. The nugget size first increased with rotation speed until 5000 rpm and then decreased due to the change of the dominant tool/workpiece contact condition from sticking to sliding. At the rotation speed of 5000 rpm, where the weld material experienced weaker thermal effect and higher-strain-rate plastic deformation, the nugget exhibited relatively small grain size, large textural intensity, and high dislocation density. Consequently, the joint showed superior nugget hardness and simultaneously a slightly low tensile ductility.

Balancing High-Speed Rotors at Low Speed

Science.gov (United States)

Giordano, J.; Zorzi, E.

1986-01-01

Flexible balancing reduces vibrations at operating speeds. Highspeed rotors in turbomachines dynamically balanced at fraction of operating rotor speed. New method takes into account rotor flexible rather than rigid.

High-speed holographic camera

International Nuclear Information System (INIS)

Novaro, Marc

The high-speed holographic camera is a disgnostic instrument using holography as an information storing support. It allows us to take 10 holograms, of an object, with exposures times of 1,5ns, separated in time by 1 or 2ns. In order to get these results easily, no mobile part is used in the set-up [fr

Simultaneous Measurement of T2 and Apparent Diffusion Coefficient (T2+ADC) in the Heart With Motion-Compensated Spin Echo Diffusion-Weighted Imaging

Science.gov (United States)

Aliotta, Eric; Moulin, Kévin; Zhang, Zhaohuan; Ennis, Daniel B.

2018-01-01

Purpose To evaluate a technique for simultaneous quantitative T2 and apparent diffusion coefficient (ADC) mapping in the heart (T2+ADC) using spin echo (SE) diffusion-weighted imaging (DWI). Theory and Methods T2 maps from T2+ADC were compared with single-echo SE in phantoms and with T2-prepared (T2-prep) balanced steady-state free precession (bSSFP) in healthy volunteers. ADC maps from T2+ADC were compared with conventional DWI in phantoms and in vivo. T2+ADC was also demonstrated in a patient with acute myocardial infarction (MI). Results Phantom T2 values from T2+ADC were closer to a single-echo SE reference than T2-prep bSSFP (−2.3 ± 6.0% vs 22.2 ± 16.3%; P T2 values from T2+ADC were significantly shorter than T2-prep bSSFP (35.8 ± 3.1 vs 46.8 ± 3.8 ms; P T2+ADC and conventional motion-compensated DWI (1.39 ± 0.18 vs 1.38 ± 0.18 mm2/ms; P = N.S.). In the patient, T2 and ADC were both significantly elevated in the infarct compared with remote myocardium (T2: 40.4 ± 7.6 vs 56.8 ± 22.0; P T2+ADC generated coregistered, free-breathing T2 and ADC maps in healthy volunteers and a patient with acute MI with no cost in accuracy, precision, or scan time compared with DWI. PMID:28516485

Recent progress on high-speed optical transmission

Directory of Open Access Journals (Sweden)

Jianjun Yu

2016-05-01

Full Text Available The recently reported high spectral efficiency (SE and high-baud-rate signal transmission are all based on digital coherent optical communications and digital signal processing (DSP. DSP simplifies the reception of advanced modulation formats and also enables the major electrical and optical impairments to be processed and compensated in the digital domain, at the transmitter or receiver side. In this paper, we summarize the research progress on high-speed signal generation and detection and also show the progress on DSP for high-speed signal detection. We also report the latest progress on multi-core and multi-mode multiplexing.

Design and construction of the 8K multi-channel gamma spectrometer module (ADC+MCD)

International Nuclear Information System (INIS)

Vu Xuan Cach; Hoang Thi Ngoc Bich; Truong Van Dat; Pham Ngoc Tuan; Dang Lanh; Tuong Thi Thu Huong; Nguyen Xuan Hai

2007-01-01

A multichannel pulse-height analyzer system (MCA) consists of an ADC with 8192 channel performance, a histogramming memory, and a visual display of the histogram, implemented on a Personal Computer (PC). The purpose of the analog-to-digital converter (ADC) is to measure the maximum amplitude of an analog pulse, and convert that value into a digital number. This digital output is a proportional representation of the analog amplitude at the ADC input. The digital ADC outputs are stored in a histogram memory, where each bin represents a pulse height interval and the number of events in each bin represents the number of events in that interval. The combination of ADC, histogramming memory and display functions are the minimum to constitute a multichannel analyzer or MCA based on PC. It is designed and fabricated on a single NIM module. The communication between MCA module and PC implements via USB bus. In our application, performance of the USB standard version 1.1 is good enough for purposes. The application program was designed in LabWIEW 8.0 software. This application is the main display and acquisition software for the MCA module. It is compatible with Windows 98SE/XP. The libraries USB driver, with their supporting files, are in the FTD2XX driver DLL Package and D2XX function 7.0 for LabWIEW supporting. These libraries are used to write custom code to control the MCA module. The 8K MCA module has the main following hardware specifications: ADC Successive-approximation type with sliding scale linearization; resolution: 8192 channels; dead time per event: 5 μs, including memory transfer; integral nonlinearity: ±0.025% over the top 98% of the dynamic range; differential nonlinearity: < ±1% over the top 98% of the dynamic range; data memory: 224 counts per channel (16 millions counts); presets; Real Time/Live Time: 1 to 232(s), Multiples of 1 s; ADC LLD and ULD Aajustable from 0 to 100% of full scale via hardware control; input accepts positive unipolar pulses in

Single-Photon Tracking for High-Speed Vision

Directory of Open Access Journals (Sweden)

Istvan Gyongy

2018-01-01

Full Text Available Quanta Imager Sensors provide photon detections at high frame rates, with negligible read-out noise, making them ideal for high-speed optical tracking. At the basic level of bit-planes or binary maps of photon detections, objects may present limited detail. However, through motion estimation and spatial reassignment of photon detections, the objects can be reconstructed with minimal motion artefacts. We here present the first demonstration of high-speed two-dimensional (2D tracking and reconstruction of rigid, planar objects with a Quanta Image Sensor, including a demonstration of depth-resolved tracking.

A high-speed interface for multi-channel analyzer

International Nuclear Information System (INIS)

Shen Ji; Zheng Zhong; Qiao Chong; Chen Ziyu; Ye Yunxiu; Ye Zhenyu

2003-01-01

This paper presents a high-speed computer interface for multi-channel analyzer based on DMA technique. Its essential principle and operating procedure are introduced. By the detecting of γ spectrum of 137 Cs with the interface, it's proved that the interface can meet the requirements of high-speed data acquisition

High-speed readout of high-Z pixel detectors with the LAMBDA detector

International Nuclear Information System (INIS)

Pennicard, D.; Smoljanin, S.; Sheviakov, I.; Xia, Q.; Rothkirch, A.; Yu, Y.; Struth, B.; Hirsemann, H.; Graafsma, H.

2014-01-01

High-frame-rate X-ray pixel detectors make it possible to perform time-resolved experiments at synchrotron beamlines, and to make better use of these sources by shortening experiment times. LAMBDA is a photon-counting hybrid pixel detector based on the Medipix3 chip, designed to combine a small pixel size of 55 μm, a large tileable module design, high speed, and compatibility with ''high-Z'' sensors for hard X-ray detection. This technical paper focuses on LAMBDA's high-speed-readout functionality, which allows a frame rate of 2000 frames per second with no deadtime between successive images. This takes advantage of the Medipix3 chip's ''continuous read-write'' function and highly parallelised readout. The readout electronics serialise this data and send it back to a server PC over two 10 Gigabit Ethernet links. The server PC controls the detector and receives, processes and stores the data using software designed for the Tango control system. As a demonstration of high-speed readout of a high-Z sensor, a GaAs LAMBDA detector was used to make a high-speed X-ray video of a computer fan

Heterostructure-based high-speed/high-frequency electronic circuit applications

Science.gov (United States)

Zampardi, P. J.; Runge, K.; Pierson, R. L.; Higgins, J. A.; Yu, R.; McDermott, B. T.; Pan, N.

1999-08-01

With the growth of wireless and lightwave technologies, heterostructure electronic devices are commodity items in the commercial marketplace [Browne J. Power-amplifier MMICs drive commercial circuits. Microwaves & RF, 1998. p. 116-24.]. In particular, HBTs are an attractive device for handset power amplifiers at 900 MHz and 1.9 GHz for CDMA applications [Lum E. GaAs technology rides the wireless wave. Proceedings of the 1997 GaAs IC Symposium, 1997. p. 11-13; "Rockwell Ramps Up". Compound Semiconductor, May/June 1997.]. At higher frequencies, both HBTs and p-HEMTs are expected to dominate the marketplace. For high-speed lightwave circuit applications, heterostructure based products on the market for OC-48 (2.5 Gb/s) and OC-192 (10 Gb/s) are emerging [http://www.nb.rockwell.com/platforms/network_access/nahome.html#5.; http://www.nortel.com/technology/opto/receivers/ptav2.html.]. Chips that operate at 40 Gb/ have been demonstrated in a number of research laboratories [Zampardi PJ, Pierson RL, Runge K, Yu R, Beccue SM, Yu J, Wang KC. hybrid digital/microwave HBTs for >30 Gb/s optical communications. IEDM Technical Digest, 1995. p. 803-6; Swahn T, Lewin T, Mokhtari M, Tenhunen H, Walden R, Stanchina W. 40 Gb/s 3 Volt InP HBT ICs for a fiber optic demonstrator system. Proceedings of the 1996 GaAs IC Symposium, 1996. p. 125-8; Suzuki H, Watanabe K, Ishikawa K, Masuda H, Ouchi K, Tanoue T, Takeyari R. InP/InGaAs HBT ICs for 40 Gbit/s optical transmission systems. Proceedings of the 1997 GaAs IC Symposium, 1997. p. 215-8]. In addition to these two markets, another area where heterostructure devices are having significant impact is for data conversion [Walden RH. Analog-to digital convertor technology comparison. Proceedings of the 1994 GaAs IC Symposium, 1994. p. 217-9; Poulton K, Knudsen K, Corcoran J, Wang KC, Nubling RB, Chang M-CF, Asbeck PM, Huang RT. A 6-b, 4 GSa/s GaAs HBT ADC. IEEE J Solid-State Circuits 1995;30:1109-18; Nary K, Nubling R, Beccue S, Colleran W

High Speed Magnetostrictive MEMS Actuated Mirror Deflectors, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — The main goal of this proposal is to develop high speed magnetostrictive and MEMS actuators for rapidly deflecting or deforming mirrors. High speed, light-weight,...

Nuclear pulse signal processing technique based on blind deconvolution method

International Nuclear Information System (INIS)

Hong Pengfei; Yang Lei; Fu Tingyan; Qi Zhong; Li Dongcang; Ren Zhongguo

2012-01-01

In this paper, we present a method for measurement and analysis of nuclear pulse signal, with which pile-up signal is removed, the signal baseline is restored, and the original signal is obtained. The data acquisition system includes FPGA, ADC and USB. The FPGA controls the high-speed ADC to sample the signal of nuclear radiation, and the USB makes the ADC work on the Slave FIFO mode to implement high-speed transmission status. Using the LabVIEW, it accomplishes online data processing of the blind deconvolution algorithm and data display. The simulation and experimental results demonstrate advantages of the method. (authors)

Value of apparent diffusion coefficient (ADC) in evaluating response ...

African Journals Online (AJOL)

Objective. To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional. T2-weighted MRI. Design.

Cadence® High High-Speed PCB Design Flow Workshop

CERN Document Server

2006-01-01

Last release of Cadence High-Speed PCB Design methodology (PE142) based on Concept-HDL schematic editor, Constraint Manager, SPECCTRAQuest signal integrity analysis tool and ALLEGRO layout associated with SPECCTRA auto router tools, is now enough developed and stable to be taken into account for high-speed board designs at CERN. The implementation of this methodology, build around the new Constraint Manager program, is essential when you have to develop a board having a lot of high-speed design rules such as terminated lines, large bus structures, maximum length, timing, crosstalk etc.. that could not be under control by traditional method. On more conventional designs, formal aspect of the methodology could avoid misunderstanding between hardware and ALLEGRO layout designers, minimizing prototype iteration, development time and price. The capability to keep trace of the original digital designer intents in schematic or board layout, loading formal constraints in EDMS, could also be considered for LHC electro...

High-speed LWR transients simulation for optimizing emergency response

International Nuclear Information System (INIS)

Wulff, W.; Cheng, H.S.; Lekach, S.V.; Mallen, A.N.; Stritar, A.

1984-01-01

The purpose of computer-assisted emergency response in nuclear power plants, and the requirements for achieving such a response, are presented. An important requirement is the attainment of realistic high-speed plant simulations at the reactor site. Currently pursued development programs for plant simulations are reviewed. Five modeling principles are established and a criterion is presented for selecting numerical procedures and efficient computer hardware to achieve high-speed simulations. A newly developed technology for high-speed power plant simulation is described and results are presented. It is shown that simulation speeds ten times greater than real-time process-speeds are possible, and that plant instrumentation can be made part of the computational loop in a small, on-site minicomputer. Additional technical issues are presented which must still be resolved before the newly developed technology can be implemented in a nuclear power plant

A Two-Step A/D Conversion and Column Self-Calibration Technique for Low Noise CMOS Image Sensors

Directory of Open Access Journals (Sweden)

Jaeyoung Bae

2014-07-01

Full Text Available In this paper, a 120 frames per second (fps low noise CMOS Image Sensor (CIS based on a Two-Step Single Slope ADC (TS SS ADC and column self-calibration technique is proposed. The TS SS ADC is suitable for high speed video systems because its conversion speed is much faster (by more than 10 times than that of the Single Slope ADC (SS ADC. However, there exist some mismatching errors between the coarse block and the fine block due to the 2-step operation of the TS SS ADC. In general, this makes it difficult to implement the TS SS ADC beyond a 10-bit resolution. In order to improve such errors, a new 4-input comparator is discussed and a high resolution TS SS ADC is proposed. Further, a feedback circuit that enables column self-calibration to reduce the Fixed Pattern Noise (FPN is also described. The proposed chip has been fabricated with 0.13 μm Samsung CIS technology and the chip satisfies the VGA resolution. The pixel is based on the 4-TR Active Pixel Sensor (APS. The high frame rate of 120 fps is achieved at the VGA resolution. The measured FPN is 0.38 LSB, and measured dynamic range is about 64.6 dB.

Continuous time sigma delta ADC design and non-idealities analysis

International Nuclear Information System (INIS)

Yuan Jun; Chen Zhenhai; Yang Yintang; Zhang Zhaofeng; Wu Jun; Wang Chao; Qian Wenrong

2011-01-01

A wide bandwidth continuous time sigma delta ADC is implemented in 130 nm CMOS. A detailed non-idealities analysis (excess loop delay, clock jitter, finite gain and GBW, comparator offset and DAC mismatch) is performed developed in Matlab/Simulink. This design is targeted for wide bandwidth applications such as video or wireless base-stations. Athird-order continuous time sigma delta modulator comprises a third-order RC operational-amplifier-based loop filter and 3-bit internal quantizer operated at 512 MHz clock frequency. The sigma delta ADC achieves 60 dB SNR and 59.3 dB SNDR over a 16-MHz signal band at an OSR of 16. The power consumption of the CT sigma delta modulator is 22 mW from the 1.2-V supply. (semiconductor integrated circuits)

Design And Construction Of The 8K Multi-Channel GAMMA Spectrometer Module (AMPLIFIER+ADC+MCD)

International Nuclear Information System (INIS)

Truong Van Dat; Hoang Thi Ngoc Bich; Pham Ngoc Tuan; Dang Lanh; Tuong Thi Thu Huong; Vu Xuan Cach

2007-01-01

A multichannel pulse-height analyzer system (MCA) consists of an spectroscopy Amplifier, ADC with 8192 channel performance, a histogramming memory, and a visual display of the histogram implemented on a Personal Computer (PC). The purpose of the analog-to-digital converter (ADC) is to measure the maximum amplitude of an analog pulse, and convert that value into a digital number. This digital output is a proportional representation of the analog amplitude at the ADC input. The digital ADC outputs are stored in a histogram memory, where each bin represents a pulse height interval and the number of events in each bin represents the number of events in that interval. The combination of ADC, histogramming memory and display functions are the minimum to constitute a multichannel analyzer or MCA based on PC. It is designed and fabricated on a single NIM module. The communication between MCA module and PC implements via USB bus. In our application, performance of the USB standard version 1.1 is good enough for purposes. The application program was designed in LabWIEW 8.0 software. This application is the main display and acquisition software for the MCA module. It is compatible with Windows 98SE/XP. The libraries USB driver, with their supporting files, are in the FTD2XX driver DLL Package and D2XX function 7.0 for LabWIEW supporting. These libraries are used to write custom code to control the MCA module. (author)

Cutting force model for high speed machining process

International Nuclear Information System (INIS)

Haber, R. E.; Jimenez, J. E.; Jimenez, A.; Lopez-Coronado, J.

2004-01-01

This paper presents cutting force-based models able to describe a high speed machining process. The model considers the cutting force as output variable, essential for the physical processes that are taking place in high speed machining. Moreover, this paper shows the mathematical development to derive the integral-differential equations, and the algorithms implemented in MATLAB to predict the cutting force in real time MATLAB is a software tool for doing numerical computations with matrices and vectors. It can also display information graphically and includes many toolboxes for several research and applications areas. Two end mill shapes are considered (i. e. cylindrical and ball end mill) for real-time implementation of the developed algorithms. the developed models are validated in slot milling operations. The results corroborate the importance of the cutting force variable for predicting tool wear in high speed machining operations. The developed models are the starting point for future work related with vibration analysis, process stability and dimensional surface finish in high speed machining processes. (Author) 19 refs

Column-Parallel Single Slope ADC with Digital Correlated Multiple Sampling for Low Noise CMOS Image Sensors

NARCIS (Netherlands)

Chen, Y.; Theuwissen, A.J.P.; Chae, Y.

2011-01-01

This paper presents a low noise CMOS image sensor (CIS) using 10/12 bit configurable column-parallel single slope ADCs (SS-ADCs) and digital correlated multiple sampling (CMS). The sensor used is a conventional 4T active pixel with a pinned-photodiode as photon detector. The test sensor was

Research on the tool holder mode in high speed machining

Science.gov (United States)

Zhenyu, Zhao; Yongquan, Zhou; Houming, Zhou; Xiaomei, Xu; Haibin, Xiao

2018-03-01

High speed machining technology can improve the processing efficiency and precision, but also reduce the processing cost. Therefore, the technology is widely regarded in the industry. With the extensive application of high-speed machining technology, high-speed tool system has higher and higher requirements on the tool chuck. At present, in high speed precision machining, several new kinds of clip heads are as long as there are heat shrinkage tool-holder, high-precision spring chuck, hydraulic tool-holder, and the three-rib deformation chuck. Among them, the heat shrinkage tool-holder has the advantages of high precision, high clamping force, high bending rigidity and dynamic balance, etc., which are widely used. Therefore, it is of great significance to research the new requirements of the machining tool system. In order to adapt to the requirement of high speed machining precision machining technology, this paper expounds the common tool holder technology of high precision machining, and proposes how to select correctly tool clamping system in practice. The characteristics and existing problems are analyzed in the tool clamping system.

High-speed photodetectors in optical communication system

Science.gov (United States)

Zhao, Zeping; Liu, Jianguo; Liu, Yu; Zhu, Ninghua

2017-12-01

This paper presents a review and discussion for high-speed photodetectors and their applications on optical communications and microwave photonics. A detailed and comprehensive demonstration of high-speed photodetectors from development history, research hotspots to packaging technologies is provided to the best of our knowledge. A few typical applications based on photodetectors are also illustrated, such as free-space optical communications, radio over fiber and millimeter terahertz signal generation systems. Project supported by the Preeminence Youth Fund of China (No. 61625504).

With a 2k-ADC to 4k-spectrometry via two biased amplifiers

Energy Technology Data Exchange (ETDEWEB)

Goerner, W; Kleeberg, H [Zentralinstitut fuer Kernforschung, Rossendorf bei Dresden (German Democratic Republic)

1978-01-12

In order to obtain the double digital spread in high resolution nuclear spectrometry, two biased amplifiers were linked in parallel mode to the 10 V-input of a 2k-ADC. The arrangement works like a hybrid (1 bit scale - 11 bits Wilkinson) converter. A careful adjustment of the two bias levels (approximately 0V and approximately 6V) and the post-amplification (approximately 2) delivered a good linearity of the 4k-spectrum.

Analysis and topology optimization design of high-speed driving spindle

Science.gov (United States)

Wang, Zhilin; Yang, Hai

2018-04-01

The three-dimensional model of high-speed driving spindle is established by using SOLIDWORKS. The model is imported through the interface of ABAQUS, A finite element analysis model of high-speed driving spindle was established by using spring element to simulate bearing boundary condition. High-speed driving spindle for the static analysis, the spindle of the stress, strain and displacement nephogram, and on the basis of the results of the analysis on spindle for topology optimization, completed the lightweight design of high-speed driving spindle. The design scheme provides guidance for the design of axial parts of similar structures.

HIGH SPEED RAILWAY LINES – FUTURE PART OF CZECH RAILWAY NETWORK?

Directory of Open Access Journals (Sweden)

Lukáš Týfa

2017-08-01

Full Text Available The paper first describes high speed rail generally and explains the relationship between high speed and conventional railway networks (according to the vehicle types in operation on the network. The core of the paper is comprised of the methodology for choosing the best route for a railway line and its application to the high speed railway connection Praha – Brno. The Algorithm used assumes the existence of more route proposals, which could be different in terms of the operational conception, line routing or types of vehicles used. The optimal variant is the one with the lowest daily cost, which includes infrastructure and vehicle costs; investment and operational costs. The results from applying this model confirmed the assumption, that a dedicated high speed railway line, only for high speed trains, has the same or lower investment costs than a line for both high speed and conventional trains. Furthermore, a dedicated high line also has a lower cost for infrastructure maintenance but a higher cost for buying high speed multiple units.

Proposal of a high rigidity and high speed rotating mechanism using a new concept hydrodynamic bearing in X-ray tube for high speed computed tomography

International Nuclear Information System (INIS)

Hattori, Hitoshi; Fukushima, Harunobu; Yoshii, Yasuo; Nakamuta, Hironori; Iwase, Mitsuo; Kitade, Koichi

2009-01-01

In this paper, a high rigidity and high speed rotating mechanism using a new concept hydrodynamic bearing in X-ray tube for high speed computed tomography is proposed. In order to obtain both the stability and the high load carrying capacity, the hydrodynamic bearing lubricated by liquid metal (Gallium alloy), named as the hybrid hydrodynamic bearing generates the lubricating film by wedge effect on the plane region between the spiral grooves under high loading condition. The parallelism between the bearing and the rotating body can be secured by optimizing the rigidity distribution of stationary shaft in the proposed rotating mechanism. By carrying out the fundamental design by numerical analyses, it has been made clear that the hybrid hydrodynamic bearing and the rotating mechanism are suitable for the X-ray tube used in the CT with ever-increasingly scanning speed. (author)

Application of Fabry-Perot velocimeter to high-speed experiments

International Nuclear Information System (INIS)

Chaw, H.H.; McMillan, C.F.; Osher, J.E.

1988-01-01

The Fabry-Perot (F-P) velocimeter is a useful instrument for measuring the velocity of objects at speeds ranging from fractions of a kilometer per second to a few tens of kilometers per second and up. Because of its immunity to electromagnetic interference and its velocity resolution, it has become the prime diagnostic tool in our electric-gun facility. Examples of its application to high speed experiments are discussed, including: electric-gun flyer studies, spallation of materials under high-speed impact, momentum-transfer studies, pressure pulse created by high-velocity impact, and detonation-wave studies in high-explosive experiments

Usefulness of Diffusion-Weighted MR Imaging for Breast Lesions: Comparing the Apparent Diffusion Coefficient (ADC) Values and the Pathologic Results

International Nuclear Information System (INIS)

Ahn, Hye Shin; Chang, Yun Woo; Choi, Kyung Hee; Kim, Hyun Joo; Hong, Seong Suk; Hwang, Jung Hwa; Kwon, Kui Hyang; Kim, Yong Bae

2011-01-01

We wanted to evaluate the ability of the apparent diffusion coefficient (ADC) values to differentiate between benign and malignant breast lesions and the normal breast parenchyma. We used breast MRI, including DWI, to obtain images of 167 breast lesions (18 benign lesions and 149 malignant lesions) of 152 women (mean age: 48.6 years, range: 24-80 years). The mean ADC values of the malignant lesions were compared to those of the benign lesions and the normal parenchyma. We compared the ADC values of IDC, DCIS and other types of breast cancer and we also compared the ADC values with the nuclear grade of IDC. The mean ADC values of the malignant lesions were lower than those of the benign lesions and the normal parenchyma (p -3 mm 2 /s for discriminating between malignant and benign lesion showed a specificity of 53% and a sensitivity of 100%, and the ADC threshold value of 1.33 X 10 -3 mm 2 /s showed a specificity of 93% and a sensitivity of 94% for discriminating between malignant and benign lesion.

HIGH RESOLUTION ANALOG / DIGITAL POWER SUPPLY CONTROLLER

International Nuclear Information System (INIS)

Medvedko, Evgeny A

2003-01-01

Corrector magnets for the SPEAR-3 synchrotron radiation source require precision, high-speed control for use with beam-based orbit feedback. A new Controller Analog/Digital Interface card (CANDI) has been developed for these purposes. The CANDI has a 24-bit DAC for current control and three 24-bit Δ-Σ ADCs to monitor current and voltages. The ADCs can be read and the DAC updated at the 4 kHz rate needed for feedback control. A precision 16-bit DAC provides on-board calibration. Programmable multiplexers control internal signal routing for calibration, testing, and measurement. Feedback can be closed internally on current setpoint, externally on supply current, or beam position. Prototype and production tests are reported in this paper. Noise is better than 17 effective bits in a 10 mHz to 2 kHz bandwidth. Linearity and temperature stability are excellent

Application of polarization in high speed, high contrast inspection

Science.gov (United States)

Novak, Matthew J.

2017-08-01

Industrial optical inspection often requires high speed and high throughput of materials. Engineers use a variety of techniques to handle these inspection needs. Some examples include line scan cameras, high speed multi-spectral and laser-based systems. High-volume manufacturing presents different challenges for inspection engineers. For example, manufacturers produce some components in quantities of millions per month, per week or even per day. Quality control of so many parts requires creativity to achieve the measurement needs. At times, traditional vision systems lack the contrast to provide the data required. In this paper, we show how dynamic polarization imaging captures high contrast images. These images are useful for engineers to perform inspection tasks in some cases where optical contrast is low. We will cover basic theory of polarization. We show how to exploit polarization as a contrast enhancement technique. We also show results of modeling for a polarization inspection application. Specifically, we explore polarization techniques for inspection of adhesives on glass.

High speed network sampling

OpenAIRE

Rindalsholt, Ole Arild

2005-01-01

Master i nettverks- og systemadministrasjon Classical Sampling methods play an important role in the current practice of Internet measurement. With today’s high speed networks, routers cannot manage to generate complete Netflow data for every packet. They have to perform restricted sampling. This thesis summarizes some of the most important sampling schemes and their applications before diving into an analysis on the effect of sampling Netflow records.

High Speed On-Wafer Characterization Laboratory

Data.gov (United States)

Federal Laboratory Consortium — At the High Speed On-Wafer Characterization Laboratory, researchers characterize and model devices operating at terahertz (THz) and millimeter-wave frequencies. The...

High-speed Maglev studies in Canada

International Nuclear Information System (INIS)

Atherton, D.L.; Eastham, A.R.

1974-01-01

This paper reports on Canadian studies of superconducting magnetic levitation and variable-speed linear synchronous motor propulsion for high-speed inter-city guided ground transport. Levitation is obtained by the interaction of vehicle-mounted superconducting magnets and the eddy currents induced in aluminium strip conductors on the guideway. Non-contact propulsion by linear synchronous motor (LSM) is obtained by using vehicle-borne superconducting magnets and powered guideway coils. A suggested guidance scheme uses a flat guideway with 'null-flux' loops overlying the LSM windings. The propulsion magnets interact with the loops and the edges of the levitation strips to provide lateral stabilization. The test facility is a 7.6m wheel, rotating with a peripheral speed of 33m/s. (author)

[The relevance of ADC value, T₁intensive rate and the clinical activities in ankylosing spondylitis sacroiliitis].

Science.gov (United States)

Zhao, Yinghua; Han, Xinai; Hu, Shaoyong; Shi, Xingliang; Zhao, Jing; Sun, Erwei; Li, Shaolin

2014-09-23

To evaluate the value of judging for the activity in AS by diffusion-weighted sequences (DWI) and enhance sequences MRI(DCE-MRI), to explore the correlation of Apparent diffusion coefficient(ADC) values, intensive rate and the clinical activity index in sacroiliitis (SIJ) of ankylosing spondylitis (AS). 56 patients prospectively choiced and diagnosed were divided into two groupsas, active group (n = 32) and chronic group (n = 24) by rheumatologist according to BASDAI and laboratory parameters. Twenty healthy adults were as control group. The values of ADC and intensive rate of all sacroiliac joints (SIJs) were measured on MRI. BASDAI score were got by Bath ankylosing spondylitis disease activity index. ESR, CPR and were got by laboratory. Statisticaly to analysis whether the parameters were significantly different amang AS active, chronic, and the control group. To assess the correlation of the values of ADC, intensive rate and BASDAI score, ESR, CPR and in SIJ. the values of ADC and intensive rate were significantly different among AS active, chronic and the control group. There were the significant correlation between the values of ADC, intensive rate and BASDAI score. Diffusion-weighted sequences and Contrast-enhanced sequences is superior to other methods in judging the activity in AS.combined with clinical activity index, the accuracy can significantly be improved to explore whether the activities of AS are.

High-speed nonvolatile CMOS/MNOS RAM

International Nuclear Information System (INIS)

Derbenwick, G.F.; Dodson, W.D.; Sokel, R.J.

1979-01-01

A bulk silicon technology for a high-speed static CMOS/MNOS RAM has been developed. Radiation-hardened, high voltage CMOS circuits have been fabricated for the memory array driving circuits and the enhancement-mode p-channel MNOS memory transistors have been fabricated using a native tunneling oxide with a 45 nm CVD Si 3 N 4 insulator deposited at 750 0 C. Read cycle times less than 350 ns and write cycle times of 1 μs are projected for the final 1Kx1 design. The CMOS circuits provide adequate speed for the write and read cycles and minimize the standby power dissipation. Retention times well in excess of 30 min are projected

High-speed cryptography and cryptanalysis

NARCIS (Netherlands)

Schwabe, P.

2011-01-01

Modern digital communication relies heavily on cryptographic protection to ensure data integrity and privacy. In order to deploy state-of-the art cryptographic primitives and protocols in real-world scenarios, one needs to highly optimize software for both speed and security. This requires careful

Advancing high-speed rail policy in the United States.

Science.gov (United States)

2012-06-01

This report builds on a review of international experience with high-speed rail projects to develop recommendations for a High-speed rail policy framework for the United States. The international review looked at the experience of Korea, Taiwan, Chin...

ADC histogram analysis of muscle lymphoma - Correlation with histopathology in a rare entity.

Science.gov (United States)

Meyer, Hans-Jonas; Pazaitis, Nikolaos; Surov, Alexey

2018-06-21

Diffusion weighted imaging (DWI) is able to reflect histopathology architecture. A novel imaging approach, namely histogram analysis, is used to further characterize lesion on MRI. The purpose of this study is to correlate histogram parameters derived from apparent diffusion coefficient- (ADC) maps with histopathology parameters in muscle lymphoma. Eight patients (mean age 64.8 years, range 45-72 years) with histopathologically confirmed muscle lymphoma were retrospectively identified. Cell count, total nucleic and average nucleic areas were estimated using ImageJ. Additionally, Ki67-index was calculated. DWI was obtained on a 1.5T scanner by using the b values of 0 and 1000 s/mm2. Histogram analysis was performed as a whole lesion measurement by using a custom-made Matlabbased application. The correlation analysis revealed statistically significant correlation between cell count and ADCmean (p=-0.76, P=0.03) as well with ADCp75 (p=-0.79, P=0.02). Kurtosis and entropy correlated with average nucleic area (p=-0.81, P=0.02, p=0.88, P=0.007, respectively). None of the analyzed ADC parameters correlated with total nucleic area and with Ki67-index. This study identified significant correlations between cellularity and histogram parameters derived from ADC maps in muscle lymphoma. Thus, histogram analysis parameters reflect histopathology in muscle tumors. Advances in knowledge: Whole lesion ADC histogram analysis is able to reflect histopathology parameters in muscle lymphomas.

Combined apparent diffusion coefficient value (ADC and 1H magnetic resonance spectroscopy (MRS in breast lesions: Benefits and limitations

Directory of Open Access Journals (Sweden)

Enass M. Khattab

2018-06-01

Conclusion: A great advantage of ADC value is the significant difference between benign and malignant lesions, because of this it plays an important role in characterization of breast lesions. MRS is the only in vivo technique which can detect tissue metabolites. In our study combined MRS with ADC value increased sensitivity in detecting lesions, while the specificity remained at lower level than that of the ADC value alone.

Diagnosis of early sacroiliitis in seronegative spondyloarthropathies by DWI and correlation of clinical and laboratory findings with ADC values

Energy Technology Data Exchange (ETDEWEB)

Gezmis, Esin; Donmez, Fuldem Y., E-mail: fuldemyildirim@yahoo.com; Agildere, Muhtesem

2013-12-01

Purpose: Sacroiliitis is one of the diagnostic criteria of seronegative SpA. The purpose of our study is to show the signal characteristics of the sacral and iliac surfaces by DWI which may contribute in early diagnosis of sacroiliitis and investigate the correlation between ADC values and clinical and laboratory parameters. Materials and methods: 62 patients with inflammatory low back pain, with a history or suspect of seronegative SpA are enrolled into the study. 40 age and sex-matched subjects without SpA constituted the control group. After obtaining routine T1 and T2 weighted sequences, echo planar imaging at b values of 0, 400 and 800 was performed. ADC values on both surfaces of the both sacroiliac joints were measured in all subjects. The CRP and sedimentation results and the presence of arthritis and enthesitis were also correlated with the ADC values. Results: ADC values on both surfaces of the both sacroiliac joints were found 0.23 × 10{sup −3} mm{sup 2}/sn in the control group. In the patient group, mean ADC value of 0.48 × 10{sup −3} mm{sup 2}/sn was obtained (p < 0.001), which was statistically significant, compatible with the increased diffusion due to medullary edema in early sacroiliitis. There was a slight correlation between CRP and ADC values; presumed to be showing the relation between the activity of the disease and the active inflammation on DWI. There was no correlation between arthritis and enthesitis and the ADC values (p > 0.001). Conclusion: DWI, by measuring ADC values, adds significant information in the early diagnosis of sacroiliitis and may help to evaluate the efficiency of the treatment.

Design and applications of a pneumatic accelerator for high speed punching

International Nuclear Information System (INIS)

Yaldiz, Sueleyman; Saglam, Haci; Unsacar, Faruk; Isik, Hakan

2007-01-01

High speed forming is an important production method that requires specially designed HERF (high energy rate forming) machines. Most of the HERF machines are devices that consist of a system in which energy is stored and a differential piston mechanism is used to release the energy at high rate. In order to eliminate the usage of specially designed HERF machines and to obtain the high speed forming benefits, the accelerator which can be adapted easily onto conventional presses has been designed and manufactured in this study. The designed energy accelerator can be incorporated into mechanical press to convert the low speed operation into high-speed operation of a hammer. Expectations from this work are reduced distortion rates, increased surface quality and precise dimensions in metal forming operations. From the performance test, the accelerator is able to achieve high speed and energy which require for high speed blanking of thick sheet metals

Assessment of rural soundscapes with high-speed train noise.

Science.gov (United States)

Lee, Pyoung Jik; Hong, Joo Young; Jeon, Jin Yong

2014-06-01

In the present study, rural soundscapes with high-speed train noise were assessed through laboratory experiments. A total of ten sites with varying landscape metrics were chosen for audio-visual recording. The acoustical characteristics of the high-speed train noise were analyzed using various noise level indices. Landscape metrics such as the percentage of natural features (NF) and Shannon's diversity index (SHDI) were adopted to evaluate the landscape features of the ten sites. Laboratory experiments were then performed with 20 well-trained listeners to investigate the perception of high-speed train noise in rural areas. The experiments consisted of three parts: 1) visual-only condition, 2) audio-only condition, and 3) combined audio-visual condition. The results showed that subjects' preference for visual images was significantly related to NF, the number of land types, and the A-weighted equivalent sound pressure level (LAeq). In addition, the visual images significantly influenced the noise annoyance, and LAeq and NF were the dominant factors affecting the annoyance from high-speed train noise in the combined audio-visual condition. In addition, Zwicker's loudness (N) was highly correlated with the annoyance from high-speed train noise in both the audio-only and audio-visual conditions. © 2013.

Quantitative diffusion tensor MR imaging of the brain: field strength related variance of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) scalars

International Nuclear Information System (INIS)

Huisman, Thierry A.G.M.; Loenneker, Thomas; Barta, Gerd; Bellemann, Matthias E.; Hennig, Juergen; Fischer, Joachim E.; Il'yasov, Kamil A.

2006-01-01

The objectives were to study the ''impact'' of the magnetic field strength on diffusion tensor imaging (DTI) metrics and also to determine whether magnetic-field-related differences in T2-relaxation times of brain tissue influence DTI measurements. DTI was performed on 12 healthy volunteers at 1.5 and 3.0 Tesla (within 2 h) using identical DTI scan parameters. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured at multiple gray and white matter locations. ADC and FA values were compared and analyzed for statistically significant differences. In addition, DTI measurements were performed at different echo times (TE) for both field strengths. ADC values for gray and white matter were statistically significantly lower at 3.0 Tesla compared with 1.5 Tesla (% change between -1.94% and -9.79%). FA values were statistically significantly higher at 3.0 Tesla compared with 1.5 Tesla (% change between +4.04 and 11.15%). ADC and FA values are not significantly different for TE=91 ms and TE=125 ms. Thus, ADC and FA values vary with the used field strength. Comparative clinical studies using ADC or FA values should consequently compare ADC or FA results with normative ADC or FA values that have been determined for the field strength used. (orig.)

High-speed imaging of explosive eruptions: applications and perspectives

Science.gov (United States)

Taddeucci, Jacopo; Scarlato, Piergiorgio; Gaudin, Damien; Capponi, Antonio; Alatorre-Ibarguengoitia, Miguel-Angel; Moroni, Monica

2013-04-01

Explosive eruptions, being by definition highly dynamic over short time scales, necessarily call for observational systems capable of relatively high sampling rates. "Traditional" tools, like as seismic and acoustic networks, have recently been joined by Doppler radar and electric sensors. Recent developments in high-speed camera systems now allow direct visual information of eruptions to be obtained with a spatial and temporal resolution suitable for the analysis of several key eruption processes. Here we summarize the methods employed to gather and process high-speed videos of explosive eruptions, and provide an overview of the several applications of these new type of data in understanding different aspects of explosive volcanism. Our most recent set up for high-speed imaging of explosive eruptions (FAMoUS - FAst, MUltiparametric Set-up,) includes: 1) a monochrome high speed camera, capable of 500 frames per second (fps) at high-definition (1280x1024 pixel) resolution and up to 200000 fps at reduced resolution; 2) a thermal camera capable of 50-200 fps at 480-120x640 pixel resolution; and 3) two acoustic to infrasonic sensors. All instruments are time-synchronized via a data logging system, a hand- or software-operated trigger, and via GPS, allowing signals from other instruments or networks to be directly recorded by the same logging unit or to be readily synchronized for comparison. FAMoUS weights less than 20 kg, easily fits into four, hand-luggage-sized backpacks, and can be deployed in less than 20' (and removed in less than 2', if needed). So far, explosive eruptions have been recorded in high-speed at several active volcanoes, including Fuego and Santiaguito (Guatemala), Stromboli (Italy), Yasur (Vanuatu), and Eyjafiallajokull (Iceland). Image processing and analysis from these eruptions helped illuminate several eruptive processes, including: 1) Pyroclasts ejection. High-speed videos reveal multiple, discrete ejection pulses within a single Strombolian

High-speed microjet generation using laser-induced vapor bubbles

Science.gov (United States)

Oudalov, Nikolai; Tagawa, Yoshiyuki; Peters, Ivo; Visser, Claas-Willem; van der Meer, Devaraj; Prosperetti, Andrea; Sun, Chao; Lohse, Detlef

2011-11-01

The generation and evolution of microjets are studied both experimentally and numerically. The jets are generated by focusing a laser pulse into a microscopic capillary tube (~50 μm) filled with water-based red dye. A vapor bubble is created instantly after shooting the laser (<1 μs), sending out a shockwave towards the curved free surface at which the high-speed microjet forms. The process of jet formation is captured using high-speed recordings at 1.0 × 106 fps. The velocity of the microjets can reach speeds of ~850 m/s while maintaining a very sharp geometry. The high-speed recordings enable us to study the effect of several parameters on the jet velocity, e.g. the absorbed energy and the distance between the laser spot and the free surface.The results show a clear dependence on these variables, even for supersonic speeds. Comparisons with numerical simulations confirm the nature of these dependencies.

Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance.

Science.gov (United States)

Pi, Shan; Cao, Rong; Qiang, Jin Wei; Guo, Yan Hui

2018-01-01

Background Diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) values are widely used in the differential diagnosis of ovarian tumors. Purpose To assess the diagnostic performance of quantitative ADC values in ovarian tumors. Material and Methods PubMed, Embase, the Cochrane Library, and local databases were searched for studies assessing ovarian tumors using quantitative ADC values. We quantitatively analyzed the diagnostic performances for two clinical problems: benign vs. malignant tumors and borderline vs. malignant tumors. We evaluated diagnostic performances by the pooled sensitivity and specificity values and by summary receiver operating characteristic (SROC) curves. Subgroup analyses were used to analyze study heterogeneity. Results From the 742 studies identified in the search results, 16 studies met our inclusion criteria. A total of ten studies evaluated malignant vs. benign ovarian tumors and six studies assessed malignant vs. borderline ovarian tumors. Regarding the diagnostic accuracy of quantitative ADC values for distinguishing between malignant and benign ovarian tumors, the pooled sensitivity and specificity values were 0.91 and 0.91, respectively. The area under the SROC curve (AUC) was 0.96. For differentiating borderline from malignant tumors, the pooled sensitivity and specificity values were 0.89 and 0.79, and the AUC was 0.91. The methodological quality of the included studies was moderate. Conclusion Quantitative ADC values could serve as useful preoperative markers for predicting the nature of ovarian tumors. Nevertheless, prospective trials focused on standardized imaging parameters are needed to evaluate the clinical value of quantitative ADC values in ovarian tumors.

Optimization of Modulator and Circuits for Low Power Continuous-Time Delta-Sigma ADC

DEFF Research Database (Denmark)

Marker-Villumsen, Niels; Bruun, Erik

2014-01-01

This paper presents a new optimization method for achieving a minimum current consumption in a continuous-time Delta-Sigma analog-to-digital converter (ADC). The method is applied to a continuous-time modulator realised with active-RC integrators and with a folded-cascode operational transconduc...... levels are swept. Based on the results of the circuit analysis, for each modulator combination the summed current consumption of the 1st integrator and quantizer of the ADC is determined. By also sweeping the partitioning of the noise power for the different circuit parts, the optimum modulator...

A 12-bit SAR ADC integrated on a multichannel silicon drift detector readout IC

Energy Technology Data Exchange (ETDEWEB)

Schembari, F., E-mail: filippo.schembari@polimi.it [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, via Golgi 40, 20133 Milano (Italy); INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Bellotti, G.; Fiorini, C. [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, via Golgi 40, 20133 Milano (Italy); INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy)

2016-07-11

A 12-bit analog-to-digital converter (ADC) addressed to Silicon-Drift Detectors (SDDs) multichannel readout ASICs for X- and gamma-ray applications is presented. Aiming at digitizing output multiplexed data from the upstream analog filters banks, the converter must ensure 11-bit accuracy and a sampling frequency of about 5 MS/s. The ADC architecture is the charge-redistribution (CR) successive-approximation register (SAR). A fully differential topology has also been chosen for better rejection of common-mode noise and disturbances. The internal DAC is made of binary-scaled capacitors, whose bottom plates are switched by the SAR logic to perform the binary search of the analog input value by means of the monotonic switching scheme. The A/D converter is integrated on SFERA, a multichannel ASIC fabricated in a standard CMOS 0.35 μm 3.3 V technology and it occupies an area of 0.42 mm{sup 2}. Simulated static performance shows monotonicity over the whole input–output characteristic. The description of the circuit topology and of inner blocks architectures together with the experimental characterization is here presented. - Highlights: • X- and γ-ray spectroscopy front-ends need to readout a high number of detectors. • Design efforts are increasingly oriented to compact and low-power ASICs. • A possible solution is the on-chip integration of the analog-to-digital converter. • A 12-bit CR successive-approximation-register ADC has been developed. • It is a suitable candidate as the digitizer to be integrated in multichannel ASICs.

Desain Layout 1-Stage ADC Pipeline 80Msps dengan Mentor Graphics 0,35µm untuk Aplikasi Kamera Kecepatan Tinggi

Directory of Open Access Journals (Sweden)

Hamzah Afandi

2012-10-01

Full Text Available Design layout 1-stage pipeline is part of the 8-stage pipeline 80 Msps ADC. Layout 1-stage pipeline consists of 3 units : op-amp, switch capacitor, precision comparator with latch. Pipeline ADC works gradually and requires synchronization of digital output 8 stage by using a unit delay circuit (D-FF. Pipeline ADC requires pulse rate (clockgenerator to support its work. Units OP-AMP transconductance CMOS components designed with the correct specification ADC applications with capacitive loads, with a large input impedance and minimize noise. The precision comparator has Vos(offset voltage approximately equal to 0V. The capacitor switch designs use NMOS switch as a switch for the sampling and multiplying. In the sampling phase and multiplying processes, the ADC requires a clock pulse with a non-intersect mode (lapping. The width of non-overlapping period was adjusted to the time of constance in the sampling process and multiplying. The total number of each pulse period equal to 12.5 ns or equal to the frequency of 80MHz. In the 1-stage layout an additional correction capacitor was required to correct residual voltage. The total area of the layout 1-stage pipeline ADC is 1-bit 200 μm x 98μm.

Low Power 2-Bit ADC Array with Serial Output, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Microwave interferometers for NASA missions such as PATH employ the GeoSTAR instrument, consisting of 600 receivers. Each receiver requires I and Q ADCs...

Utility of whole-lesion ADC histogram metrics for assessing the malignant potential of pancreatic intraductal papillary mucinous neoplasms (IPMNs).

Science.gov (United States)

Hoffman, David H; Ream, Justin M; Hajdu, Christina H; Rosenkrantz, Andrew B

2017-04-01

To evaluate whole-lesion ADC histogram metrics for assessing the malignant potential of pancreatic intraductal papillary mucinous neoplasms (IPMNs), including in comparison with conventional MRI features. Eighteen branch-duct IPMNs underwent MRI with DWI prior to resection (n = 16) or FNA (n = 2). A blinded radiologist placed 3D volumes-of-interest on the entire IPMN on the ADC map, from which whole-lesion histogram metrics were generated. The reader also assessed IPMN size, mural nodularity, and adjacent main-duct dilation. Benign (low-to-intermediate grade dysplasia; n = 10) and malignant (high-grade dysplasia or invasive adenocarcinoma; n = 8) IPMNs were compared. Whole-lesion ADC histogram metrics demonstrating significant differences between benign and malignant IPMNs were: entropy (5.1 ± 0.2 vs. 5.4 ± 0.2; p = 0.01, AUC = 86%); mean of the bottom 10th percentile (2.2 ± 0.4 vs. 1.6 ± 0.7; p = 0.03; AUC = 81%); and mean of the 10-25th percentile (2.8 ± 0.4 vs. 2.3 ± 0.6; p = 0.04; AUC = 79%). The overall mean ADC, skewness, and kurtosis were not significantly different between groups (p ≥ 0.06; AUC = 50-78%). For entropy (highest performing histogram metric), an optimal threshold of >5.3 achieved a sensitivity of 100%, a specificity of 70%, and an accuracy of 83% for predicting malignancy. No significant difference (p = 0.18-0.64) was observed between benign and malignant IPMNs for cyst size ≥3 cm, adjacent main-duct dilatation, or mural nodule. At multivariable analysis of entropy in combination with all other ADC histogram and conventional MRI features, entropy was the only significant independent predictor of malignancy (p = 0.004). Although requiring larger studies, ADC entropy obtained from 3D whole-lesion histogram analysis may serve as a biomarker for identifying the malignant potential of IPMNs, independent of conventional MRI features.

High speed railway track dynamics models, algorithms and applications

CERN Document Server

Lei, Xiaoyan

2017-01-01

This book systematically summarizes the latest research findings on high-speed railway track dynamics, made by the author and his research team over the past decade. It explores cutting-edge issues concerning the basic theory of high-speed railways, covering the dynamic theories, models, algorithms and engineering applications of the high-speed train and track coupling system. Presenting original concepts, systematic theories and advanced algorithms, the book places great emphasis on the precision and completeness of its content. The chapters are interrelated yet largely self-contained, allowing readers to either read through the book as a whole or focus on specific topics. It also combines theories with practice to effectively introduce readers to the latest research findings and developments in high-speed railway track dynamics. It offers a valuable resource for researchers, postgraduates and engineers in the fields of civil engineering, transportation, highway & railway engineering.

Plasma-Assisted Chemistry in High-Speed Flow

International Nuclear Information System (INIS)

Leonov, Sergey B.; Yarantsev, Dmitry A.; Napartovich, Anatoly P.; Kochetov, Igor V.

2007-01-01

Fundamental problems related to the high-speed combustion are analyzed. The result of plasma-chemical modeling is presented as a motivation of experimental activity. Numerical simulations of the effect of uniform non-equilibrium discharge on the premixed hydrogen and ethylene-air mixture in supersonic flow demonstrate an advantage of such a technique over a heating. Experimental results on multi-electrode non-uniform discharge maintenance behind wallstep and in cavity of supersonic flow are presented. The model test on hydrogen and ethylene ignition is demonstrated at direct fuel injection to low-temperature high-speed airflow

Thermomechanical simulations and experimental validation for high speed incremental forming

Science.gov (United States)

Ambrogio, Giuseppina; Gagliardi, Francesco; Filice, Luigino; Romero, Natalia

2016-10-01

Incremental sheet forming (ISF) consists in deforming only a small region of the workspace through a punch driven by a NC machine. The drawback of this process is its slowness. In this study, a high speed variant has been investigated from both numerical and experimental points of view. The aim has been the design of a FEM model able to perform the material behavior during the high speed process by defining a thermomechanical model. An experimental campaign has been performed by a CNC lathe with high speed to test process feasibility. The first results have shown how the material presents the same performance than in conventional speed ISF and, in some cases, better material behavior due to the temperature increment. An accurate numerical simulation has been performed to investigate the material behavior during the high speed process confirming substantially experimental evidence.

High-Speed Data Acquisition and Digital Signal Processing System for PET Imaging Techniques Applied to Mammography

Science.gov (United States)

Martinez, J. D.; Benlloch, J. M.; Cerda, J.; Lerche, Ch. W.; Pavon, N.; Sebastia, A.

2004-06-01

This paper is framed into the Positron Emission Mammography (PEM) project, whose aim is to develop an innovative gamma ray sensor for early breast cancer diagnosis. Currently, breast cancer is detected using low-energy X-ray screening. However, functional imaging techniques such as PET/FDG could be employed to detect breast cancer and track disease changes with greater sensitivity. Furthermore, a small and less expensive PET camera can be utilized minimizing main problems of whole body PET. To accomplish these objectives, we are developing a new gamma ray sensor based on a newly released photodetector. However, a dedicated PEM detector requires an adequate data acquisition (DAQ) and processing system. The characterization of gamma events needs a free-running analog-to-digital converter (ADC) with sampling rates of more than 50 Ms/s and must achieve event count rates up to 10 MHz. Moreover, comprehensive data processing must be carried out to obtain event parameters necessary for performing the image reconstruction. A new generation digital signal processor (DSP) has been used to comply with these requirements. This device enables us to manage the DAQ system at up to 80 Ms/s and to execute intensive calculi over the detector signals. This paper describes our designed DAQ and processing architecture whose main features are: very high-speed data conversion, multichannel synchronized acquisition with zero dead time, a digital triggering scheme, and high throughput of data with an extensive optimization of the signal processing algorithms.

High Speed Photomicrography

Science.gov (United States)

Hyzer, William G.

1983-03-01

One of the most challenging areas in applying high-speed photography and videography in the plant and laboratory is in the recording of rapid events at macro and microscopic scales. Depth of field, exposure efficiency, working distance, and required exposure time are all reduced as optical magnification is increased, which severely taxes the skill and ingenuity of workers interested in recording any fast moving phenomena through the microscope or with magnifying lenses. This paper defines the problems inherent in photographing within macro and microscopic ranges and offers a systematic approach to optimizing the selection of equipment and choice of applicable techniques.

Material requirements for the High Speed Civil Transport

Science.gov (United States)

Stephens, Joseph R.; Hecht, Ralph J.; Johnson, Andrew M.

1993-01-01

Under NASA-sponsored High Speed Research (HSR) programs, the materials and processing requirements have been identified for overcoming the environmental and economic barriers of the next generation High Speed Civil Transport (HSCT) propulsion system. The long (2 to 5 hours) supersonic cruise portion of the HSCT cycle will place additional durability requirements on all hot section engine components. Low emissions combustor designs will require high temperature ceramic matrix composite liners to meet an emission goal of less than 5g NO(x) per Kg fuel burned. Large axisymmetric and two-dimensional exhaust nozzle designs are now under development to meet or exceed FAR 36 Stage III noise requirements, and will require lightweight, high temperature metallic, intermetallic, and ceramic matrix composites to reduce nozzle weight and meet structural and acoustic component performance goals. This paper describes and discusses the turbomachinery, combustor, and exhaust nozzle requirements of the High Speed Civil Transport propulsion system.

SU-F-303-13: Initial Evaluation of Four Dimensional Diffusion- Weighted MRI (4D-DWI) and Its Effect On Apparent Diffusion Coefficient (ADC) Measurement

Energy Technology Data Exchange (ETDEWEB)

Liu, Y [Duke University Medical Physics Program (United States); Yin, F; Czito, B; Bashir, M; Palta, M; Cai, J [Duke University Medical Center, Durham, NC (United States); Zhong, X; Dale, B [Siemens Healthcare, Durham, NC (United States)

2015-06-15

Purpose: Diffusion-weighted imaging(DWI) has been shown to have superior tumor-to-tissue contrast for cancer detection.This study aims at developing and evaluating a four dimensional DWI(4D-DWI) technique using retrospective sorting method for imaging respiratory motion for radiotherapy planning,and evaluate its effect on Apparent Diffusion Coefficient(ADC) measurement. Materials/Methods: Image acquisition was performed by repeatedly imaging a volume of interest using a multi-slice single-shot 2D-DWI sequence in the axial planes and cine MRI(served as reference) using FIESTA sequence.Each 2D-DWI image were acquired in xyz-diffusion-directions with a high b-value(b=500s/mm2).The respiratory motion was simultaneously recorded using bellows.Retrospective sorting was applied in each direction to reconstruct 4D-DWI.The technique was evaluated using a computer simulated 4D-digital human phantom(XCAT),a motion phantom and a healthy volunteer under an IRB-approved study.Motion trajectories of regions-of-interests(ROI) were extracted from 4D-DWI and compared with reference.The mean motion trajectory amplitude differences(D) between the two was calculated.To quantitatively analyze the motion artifacts,XCAT were controlled to simulate regular motion and the motions of 10 liver cancer patients.4D-DWI,free-breathing DWI(FB- DWI) were reconstructed.Tumor volume difference(VD) of each phase of 4D-DWI and FB-DWI from the input static tumor were calculated.Furthermore, ADC was measured for each phase of 4D-DWI and FB-DWI data,and mean tumor ADC values(M-ADC) were calculated.Mean M-ADC over all 4D-DWI phases was compared with M-ADC calculated from FB-DWI. Results: 4D-DWI of XCAT,the motion phantom and the healthy volunteer demonstrated the respiratory motion clearly.ROI D values were 1.9mm,1.7mm and 2.0mm,respectively.For motion artifacts analysis,XCAT 4D-DWI images show much less motion artifacts compare to FB-DWI.Mean VD for 4D-WDI and FB-DWI were 8.5±1.4% and 108±15

High-Speed Sealift Technology Development Plan

National Research Council Canada - National Science Library

2002-01-01

.... The purpose of the project was to define the technology investments required to enable development of the high-speed commercial and military ships needed to provide realistic future mission capabilities...

Diagnostics of high-speed streams and coronal holes using geomagnetic pulsations

International Nuclear Information System (INIS)

Bol'shakova, O.V.; Troitskaya, V.A.

1980-01-01

In order to study the relations of high-speed solar wind streams and coronal holes analyzed are the parameters of geomagnetic pulsations of the Rs3 type and of high-speed streams at the decrease branch and in the minimum of solar activity. On the basis of the analysis of exciting pulsation regime determined are the differences in characteristics of high-speed stream properties. Presented are the graphical distributions of a number of occurrances of high-speed streams, coronal holes and pure regimes of Rs3R pulsations in several sections of 1973 in the Sun rotations of N1903-1919 and of the change of solar wind velocity while passing through the high-speed streams. It is found that Rs3R occurrance can serve an indicator of the high-speed flux connection with the large equatorial coronal hole. On the basis of the analysis of exciting pulsation properties determined are the differences in the stream characteristics. However the preliminary estimates permit to adopt neither the first nor the second of the existing hypotheses on the sourse of formation of high-speed streams

Optimal design of high-speed loading spindle based on ABAQUS

Science.gov (United States)

Yang, Xudong; Dong, Yu; Ge, Qingkuan; Yang, Hai

2017-12-01

The three-dimensional model of high-speed loading spindle is established by using ABAQUS’s modeling module. A finite element analysis model of high-speed loading spindle was established by using spring element to simulate bearing boundary condition. The static and dynamic performance of the spindle structure with different specifications of the rectangular spline and the different diameter neck of axle are studied in depth, and the influence of different spindle span on the static and dynamic performance of the high-speed loading spindle is studied. Finally, the optimal structure of the high-speed loading spindle is obtained. The results provide a theoretical basis for improving the overall performance of the test-bed

Comprehensive surface treatment of high-speed steel tool

Science.gov (United States)

Fedorov, Sergey V.; Aleshin, Sergey V.; Swe, Min Htet; Abdirova, Raushan D.; Kapitanov, Alexey V.; Egorov, Sergey B.

2018-03-01

One of the promising directions of hardening of high-speed steel tool is the creation on their surface of the layered structures with the gradient of physic-chemical properties between the wear-resistant coatings to the base material. Among the methods of such surface modification, a special process takes place based on the use of pulsed high-intensity charged particle beams. The high speed of heating and cooling allows structural-phase transformations in the surface layer, which cannot be realized in a stationary mode. The treatment was conducted in a RITM-SP unit, which constitutes a combination of a source of low-energy high-current electron beams "RITM" and two magnetron spraying systems on a single vacuum chamber. The unit enables deposition of films on the surface of the desired product and subsequent liquid-phase mixing of materials of the film and the substrate by an intense pulse electron beam. The article discusses features of the structure of the subsurface layer of high-speed steel M2, modified by surface alloying of a low-energy high-current electron beam, and its effect on the wear resistance of the tool when dry cutting hard to machine Nickel alloy. A significant decrease of intensity of wear of high-speed steel with combined treatment happens due to the displacement of the zone of wear and decrease the radius of rounding of the cutting edge because of changes in conditions of interaction with the material being treated.

Design and Optimization of Multi-bit Front-end Stage and Scaled Back-end Stages of Pipelined ADCs

NARCIS (Netherlands)

Quinn, P.J.; Roermund, van A.H.M.

2005-01-01

In this paper, an error analysis is presented to aid the design of a pipeline multi-bit front-end stage. It is demonstrated and quantified how the capacitor matching requirement can be reduced in high-resolution pipeline ADCs. The paper continues by analyzing the optimal design for low power of the

Application of porous-media theory to the investigation of water ADC changes in rabbit Achilles tendon caused by tensile loading

Science.gov (United States)

Wellen, J.; Helmer, K. G.; Grigg, P.; Sotak, C. H.

2004-09-01

The water apparent diffusion coefficient (ADC) in rabbit Achilles tendon is anisotropic, diffusion-time dependent, and changes as a function of tensile load. Water ADC changes of tendon under mechanical load are thought to be due to the extrusion of water from the more restricted tendon core to a relatively unrestricted bulk phase at the periphery (rim) of the tendon. Tensile loading may influence water ADC values by changing the spatial separation of restricting barriers (e.g., increasing the tendon fibril packing density). To explore this issue, we have applied porous-media theory to the investigation of water ADC changes in rabbit Achilles tendon under two different mechanical loading conditions (a baseline condition with a minimal tensile stress and a second in which the tensile stress was approximately 1 MPa). Diffusion sensitivity was applied in directions parallel and perpendicular to the long axis of the tendon. The short diffusion-time behavior of the resulting time-dependent ADC curves was used to indirectly infer information regarding the average surface area to volume ratio of the space available for molecular diffusion. From these values, we estimated a 40% reduction in volume available for diffusion in the perpendicular direction after tensile loading, but only a 10% reduction in the parallel direction. These differences are consistent with the known geometry of the tendon microstructure and suggest an increase in fibril packing density upon loading. The long diffusion-time behavior of the time-dependent ADC curves was used to indirectly infer the tortuosity of the diffusion pathways through the interstitial space. The tortuosity in the direction perpendicular to the tendon long axis was approximately 2.5 times greater than that in the parallel direction. Stimulated-echo measurement of the ADC values at longer diffusion times resulted in T1 spin editing of water with shorter T1 values (and correspondingly lower ADC values). The resulting increase in

CUSTOMER PERCEPTION ON ALTERNATIVE DELIVERY CHANNEL (ADC OF BANKS IN BANGLADESH

Directory of Open Access Journals (Sweden)

Shahed BIN SADIQUE

2016-12-01

Full Text Available This paper aims at understanding the level of customer’s perception on alternative delivery channel of different commercial schedule banks of Bangladesh. Considering the significant development in technology and for sustainability, banking industry in Bangladesh has expanded banking operation through offering different ADCs to attract customers which are ultimately changing the perception of customers in the long run. Based on this reality, data were collected from a survey and a usable sample of 134 was taken for analysis. KAPPA test and multiple regression model is used to analyze the overall consistency of respondent’s responses and measurement of consumers’ perception. The results of the survey show that visibility, availability, self-security, confidential transaction ability, easiness and simplicity in the procedure of ADC makes it more attractive to consumer. The findings also suggest that security of physical establishment of ADC is vital though banks have given less importance to it. From the study, it is found that in order to change perception and to attract more users to banking; it is not going to be enough to make the system easy to interact with. Banks should develop more secured and private alternative delivery channels that will be reliable to their customers. Thus, management attention might be effectively focused on the development of such sectors that have been properly identified in this research.

Customer Perception on Alternative Delivery Channel (ADC of Banks in Bangladesh

Directory of Open Access Journals (Sweden)

Shahed BIN SADIQUE

2016-12-01

Full Text Available This paper aims at understanding the level of customer’s perception on alternative delivery channel of different commercial schedule banks of Bangladesh. Considering the significant development in technology and for sustainability, banking industry in Bangladesh has expanded banking operation through offering different ADCs to attract customers which are ultimately changing the perception of customers in the long run. Based on this reality, data were collected from a survey and a usable sample of 134 was taken for analysis. KAPPA test and multiple regression model is used to analyze the overall consistency of respondent’s responses and measurement of consumers’ perception. The results of the survey show that visibility, availability, self-security, confidential transaction ability, easiness and simplicity in the procedure of ADC makes it more attractive to consumer. The findings also suggest that security of physical establishment of ADC is vital though banks have given less importance to it. From the study, it is found that in order to change perception and to attract more users to banking; it is not going to be enough to make the system easy to interact with. Banks should develop more secured and private alternative delivery channels that will be reliable to their customers. Thus, management attention might be effectively focused on the development of such sectors that have been properly identified in this research.

High-speed railway signal trackside equipment patrol inspection system

Science.gov (United States)

Wu, Nan

2018-03-01

High-speed railway signal trackside equipment patrol inspection system comprehensively applies TDI (time delay integration), high-speed and highly responsive CMOS architecture, low illumination photosensitive technique, image data compression technique, machine vision technique and so on, installed on high-speed railway inspection train, and achieves the collection, management and analysis of the images of signal trackside equipment appearance while the train is running. The system will automatically filter out the signal trackside equipment images from a large number of the background image, and identify of the equipment changes by comparing the original image data. Combining with ledger data and train location information, the system accurately locate the trackside equipment, conscientiously guiding maintenance.

Studying DAC capacitor-array degradation in charge-redistribution SAR ADCs

NARCIS (Netherlands)

Khan, M.A.; Kerkhoff, Hans G.

2014-01-01

In this paper, system-level behavioural models are used to simulate the aging-related degradation effects in the DAC capacitor array of a charge-redistribution successive approximation register (SAR) ADC because of the large calculation time of transistor-level aging simulators. A

Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping

Energy Technology Data Exchange (ETDEWEB)

Ahn, K.J.; You, W.J.; Jeong, S.L.; Lee, J.W.; Kim, B.S.; Lee, J.H.; Hahn, S.T. [Dept. of Radiology, The Catholic Univ. of Korea, St. Mary' s Hospital, Seoul (Korea); Yang, D.W.; Son, Y.M. [Dept. of Neurology, The Catholic Univ. of Korea, St. Mary' s Hospital, Seoul (Korea)

2004-12-01

Typically, reversible posterior leukoencephalopathy syndrome (RPLS) involves the parieto-occipital lobes. When regions of the brain other than the parieto-occipital lobes are predominantly involved, the syndrome can be called atypical RPLS. The purpose of this study is to find radiological and pathophysiological features of atypical RPLS by using diffusion-weighted imaging (D-WI). We retrospectively reviewed seven patients (two with eclampsia, one with cyclosporine neurotoxicity, and four with hypertensive encephalopathy) with atypical MR manifestations of RPLS. Changes in signal intensity on T2-weighted imaging (T2-WI) and D-WI, and ADC ratio, were analyzed. In patients with atypical manifestation of RPLS, high signal intensities on T2-WI were noted in the frontal lobe, basal ganglia, thalamus, brainstem, and subcortical white matter in regions other than the parieto-occipital lobes. These areas of increased signal intensities on T2-WI showed increased ADC values, representing vasogenic edema in all seven patients. This result should be very useful in differentiating atypical RPLS from other metabolic brain disorders that affect the same sites with cytotoxic edema. (orig.)

Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping

International Nuclear Information System (INIS)

Ahn, K.J.; You, W.J.; Jeong, S.L.; Lee, J.W.; Kim, B.S.; Lee, J.H.; Hahn, S.T.; Yang, D.W.; Son, Y.M.

2004-01-01

Typically, reversible posterior leukoencephalopathy syndrome (RPLS) involves the parieto-occipital lobes. When regions of the brain other than the parieto-occipital lobes are predominantly involved, the syndrome can be called atypical RPLS. The purpose of this study is to find radiological and pathophysiological features of atypical RPLS by using diffusion-weighted imaging (D-WI). We retrospectively reviewed seven patients (two with eclampsia, one with cyclosporine neurotoxicity, and four with hypertensive encephalopathy) with atypical MR manifestations of RPLS. Changes in signal intensity on T2-weighted imaging (T2-WI) and D-WI, and ADC ratio, were analyzed. In patients with atypical manifestation of RPLS, high signal intensities on T2-WI were noted in the frontal lobe, basal ganglia, thalamus, brainstem, and subcortical white matter in regions other than the parieto-occipital lobes. These areas of increased signal intensities on T2-WI showed increased ADC values, representing vasogenic edema in all seven patients. This result should be very useful in differentiating atypical RPLS from other metabolic brain disorders that affect the same sites with cytotoxic edema. (orig.)

Low Power 1-Bit ADC Array with Serial Output, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Microwave interferometers for NASA missions such as PATH and SCLP consist of up to 900 receivers. Each receiver requires I and Q ADCs (analog-to-digital converters)...

NRL 12-Bit, 213 Msps ADC HSAD9 MCM Evaluation Board

National Research Council Canada - National Science Library

Thai, Khanh

1999-01-01

The MCM Evaluation Board is a 6" by 6" test fixture designed for evaluating the HSAD9 MCM, a completely self contained ADC multichip module that digitizes incoming differential analog signals to 12...

A second-order ΣΔ ADC using sputtered IGZO TFTs

CERN Document Server

Correia, Ana Paula Pinto; Goes, João Carlos da Palma

2016-01-01

This book discusses the design, electrical simulation and layout of a 2nd-order ∑∆ analog-to-digital converter (ADC), using oxide thin-film transistors (TFTs) technology. The authors provide a unified view of materials science and electronics engineering, in order to guide readers from both fields through key topics. To accomplish this goal, background regarding materials, device physics, characterization techniques, circuit design and layout is given together with a detailed discussion of experimental data. The final simulation results clearly demonstrate the potential of the proposed circuit-level techniques, which enables the implementation of robust and energy efficient ADCs based on oxide TFTs, for moderate resolutions and conversion-rates. Combines materials science and electronics engineering in the same book, making it possible to obtain a general overview, from TFTs production and characterization to their integration in relatively complex circuits; Adapts an a-Si:H TFT RPI model to simulate the ...

Pulse-burst PIV in a high-speed wind tunnel

International Nuclear Information System (INIS)

Beresh, Steven; Kearney, Sean; Wagner, Justin; Guildenbecher, Daniel; Henfling, John; Spillers, Russell; Pruett, Brian; Jiang, Naibo; Slipchenko, Mikhail; Mance, Jason; Roy, Sukesh

2015-01-01

Time-resolved particle image velocimetry (TR-PIV) has been achieved in a high-speed wind tunnel, providing velocity field movies of compressible turbulence events. The requirements of high-speed flows demand greater energy at faster pulse rates than possible with the TR-PIV systems developed for low-speed flows. This has been realized using a pulse-burst laser to obtain movies at up to 50 kHz, with higher speeds possible at the cost of spatial resolution. The constraints imposed by use of a pulse-burst laser are limited burst duration of 10.2 ms and a low duty cycle for data acquisition. Pulse-burst PIV has been demonstrated in a supersonic jet exhausting into a transonic crossflow and in transonic flow over a rectangular cavity. The velocity field sequences reveal the passage of turbulent structures and can be used to find velocity power spectra at every point in the field, providing spatial distributions of acoustic modes. The present work represents the first use of TR-PIV in a high-speed ground-test facility. (paper)

Modifications of the optical properties for DAM-ADC nuclear track detector exposed to alpha particles

Science.gov (United States)

Rammah, Y. S.; Awad, E. M.

2018-05-01

Modifications of the optical properties of diallyl maleate-allyl diglycol carbonate (DAM-ADC) nuclear detector induced by alpha particles are described. DAM-ADC samples were irradiated perpendicularly by thin 241Am disk source that emits alpha particles with 5.48 MeV. The optical absorption has been measured using the ultraviolet-visible (UV-1100) spectroscopy. It was found that DAM-ADC polymer shows substantial modifications in its optical characteristics upon irradiated with alpha particles with different energies. The optical energy band gap (Egap) for the detector was calculated for the direct and the indirect allowed transitions in K-space using two approaches (Tauc's model and absorption spectrum fitting (ASF) method). Urbach's energy (Ea), number of carbon atoms per conjugated length (N), number of carbon atoms per cluster (M), and refractive index (n) for the present samples were determined. Results reveal that the values of energy gap in direct transition are greater than those of indirect, before and after irradiation. (Egap), (Ea), (N), (M), and (n) of the present samples are changed significantly with irradiation time and value of alpha energy. Results reflect the possibility of using DAM-ADC polymer track detectors to estimate alpha particle energies using the variation of the absorbance.

An ADC-free adaptive interface circuit of resistive sensor for electronic nose system.

Science.gov (United States)

Chang, Chia-Lin; Chiu, Shih-Wen; Tang, Kea-Tiong

2013-01-01

The initial resistance of chemiresistive gas sensors could be affected by temperature, humidity, and background odors. In a sensing system, the traditional interface circuit always requires an ADC to convert analog signal to digital signal. In this paper, we propose an ADC-free adaptive interface circuit for a resistive gas sensor to read sensor signal and cancel the baseline drift. Furthermore, methanol was used to test the proposed interface circuit, which was connected with a FIGARO® gas sensor. This circuit was fabricated by TSMC 0.18 µm CMOS process, and consumed 86.41 µW under 1 V supply voltage.

49 CFR 38.175 - High-speed rail cars, monorails and systems.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false High-speed rail cars, monorails and systems. 38....175 High-speed rail cars, monorails and systems. (a) All cars for high-speed rail systems, including... monorail systems operating primarily on dedicated rail (i.e., not used by freight trains) or guideway, in...

Noise in the passenger cars of high-speed trains.

Science.gov (United States)

Hong, Joo Young; Cha, Yongwon; Jeon, Jin Yong

2015-12-01

The aim of this study is to investigate the effects of both room acoustic conditions and spectral characteristics of noises on acoustic discomfort in a high-speed train's passenger car. Measurement of interior noises in a high-speed train was performed when the train was operating at speeds of 100 km/h and 300 km/h. Acoustic discomfort caused by interior noises was evaluated by paired comparison methods based on the variation of reverberation time (RT) in a passenger car and the spectral differences in interior noises. The effect of RT on acoustic discomfort was not significant, whereas acoustic discomfort significantly varied depending on spectral differences in noise. Acoustic discomfort increased with increment of the sound pressure level (SPL) ratio at high frequencies, and variation in high-frequency noise components were described using sharpness. Just noticeable differences of SPL with low- and high-frequency components were determined to be 3.7 and 2.9 dB, respectively. This indicates that subjects were more sensitive to differences in SPLs at the high-frequency range than differences at the low-frequency range. These results support that, for interior noises, reduction in SPLs at high frequencies would significantly contribute to improved acoustic quality in passenger cars of high-speed trains.

High Speed Rail (HSR) in the United States

Science.gov (United States)

2009-12-08

announced that it will expand the capacity on its aging high speed line between Tokyo and Osaka, the most heavily traveled intercity rail segment in the...United States, in most of these countries intercity rail travel (including both conventional and high speed rail) represents less than 10% of all...that is sometimes mentioned by its advocates. Intercity passenger rail transport is relatively safe, at least compared with highway travel . And HSR in

High-speed optical signal processing using time lenses

DEFF Research Database (Denmark)

Galili, Michael; Hu, Hao; Guan, Pengyu

2015-01-01

This paper will discuss time lenses and their broad range of applications. A number of recent demonstrations of complex high-speed optical signal processing using time lenses will be outlined with focus on the operating principle.......This paper will discuss time lenses and their broad range of applications. A number of recent demonstrations of complex high-speed optical signal processing using time lenses will be outlined with focus on the operating principle....

A Design of a New Column-Parallel Analog-to-Digital Converter Flash for Monolithic Active Pixel Sensor

Directory of Open Access Journals (Sweden)

Mostafa Chakir

2017-01-01

Full Text Available The CMOS Monolithic Active Pixel Sensor (MAPS for the International Linear Collider (ILC vertex detector (VXD expresses stringent requirements on their analog readout electronics, specifically on the analog-to-digital converter (ADC. This paper concerns designing and optimizing a new architecture of a low power, high speed, and small-area 4-bit column-parallel ADC Flash. Later in this study, we propose to interpose an S/H block in the converter. This integration of S/H block increases the sensitiveness of the converter to the very small amplitude of the input signal from the sensor and provides a sufficient time to the converter to be able to code the input signal. This ADC is developed in 0.18 μm CMOS process with a pixel pitch of 35 μm. The proposed ADC responds to the constraints of power dissipation, size, and speed for the MAPS composed of a matrix of 64 rows and 48 columns where each column ADC covers a small area of 35 × 336.76 μm2. The proposed ADC consumes low power at a 1.8 V supply and 100 MS/s sampling rate with dynamic range of 125 mV. Its DNL and INL are 0.0812/−0.0787 LSB and 0.0811/−0.0787 LSB, respectively. Furthermore, this ADC achieves a high speed more than 5 GHz.

A Design of a New Column-Parallel Analog-to-Digital Converter Flash for Monolithic Active Pixel Sensor.

Science.gov (United States)

Chakir, Mostafa; Akhamal, Hicham; Qjidaa, Hassan

2017-01-01

The CMOS Monolithic Active Pixel Sensor (MAPS) for the International Linear Collider (ILC) vertex detector (VXD) expresses stringent requirements on their analog readout electronics, specifically on the analog-to-digital converter (ADC). This paper concerns designing and optimizing a new architecture of a low power, high speed, and small-area 4-bit column-parallel ADC Flash. Later in this study, we propose to interpose an S/H block in the converter. This integration of S/H block increases the sensitiveness of the converter to the very small amplitude of the input signal from the sensor and provides a sufficient time to the converter to be able to code the input signal. This ADC is developed in 0.18  μ m CMOS process with a pixel pitch of 35  μ m. The proposed ADC responds to the constraints of power dissipation, size, and speed for the MAPS composed of a matrix of 64 rows and 48 columns where each column ADC covers a small area of 35 × 336.76  μ m 2 . The proposed ADC consumes low power at a 1.8 V supply and 100 MS/s sampling rate with dynamic range of 125 mV. Its DNL and INL are 0.0812/-0.0787 LSB and 0.0811/-0.0787 LSB, respectively. Furthermore, this ADC achieves a high speed more than 5 GHz.

High-speed parallel counter

International Nuclear Information System (INIS)

Gus'kov, B.N.; Kalinnikov, V.A.; Krastev, V.R.; Maksimov, A.N.; Nikityuk, N.M.

1985-01-01

This paper describes a high-speed parallel counter that contains 31 inputs and 15 outputs and is implemented by integrated circuits of series 500. The counter is designed for fast sampling of events according to the number of particles that pass simultaneously through the hodoscopic plane of the detector. The minimum delay of the output signals relative to the input is 43 nsec. The duration of the output signals can be varied from 75 to 120 nsec

Influence of “J”-Curve Spring Stiffness on Running Speeds of Segmented Legs during High-Speed Locomotion

Directory of Open Access Journals (Sweden)

Runxiao Wang

2016-01-01

Full Text Available Both the linear leg spring model and the two-segment leg model with constant spring stiffness have been broadly used as template models to investigate bouncing gaits for legged robots with compliant legs. In addition to these two models, the other stiffness leg spring models developed using inspiration from biological characteristic have the potential to improve high-speed running capacity of spring-legged robots. In this paper, we investigate the effects of “J”-curve spring stiffness inspired by biological materials on running speeds of segmented legs during high-speed locomotion. Mathematical formulation of the relationship between the virtual leg force and the virtual leg compression is established. When the SLIP model and the two-segment leg model with constant spring stiffness and with “J”-curve spring stiffness have the same dimensionless reference stiffness, the two-segment leg model with “J”-curve spring stiffness reveals that (1 both the largest tolerated range of running speeds and the tolerated maximum running speed are found and (2 at fast running speed from 25 to 40/92 m s−1 both the tolerated range of landing angle and the stability region are the largest. It is suggested that the two-segment leg model with “J”-curve spring stiffness is more advantageous for high-speed running compared with the SLIP model and with constant spring stiffness.

High speed rotary drum

Energy Technology Data Exchange (ETDEWEB)

Sagara, H

1970-03-25

A high speed rotary drum is disclosed in which the rotor vessel is a double-wall structure comprising an inner wave-shaped pipe inserted coaxially within an outer straight pipe, the object being to provide a strengthened composite light-weight structure. Since force induced axial deformation of the straight pipe and radial deformation of the corrugated pipe are small, the composite effectively resists external forces and, if the waves of the inner pipe are given a sufficient amplitude, the thickness of both pipes may be reduced to lower the overall weight. Thus high angular velocities can be obtained to separate U/sup 235/ from gaseous UF/sub 6/.

Coronal holes and high-speed wind streams

International Nuclear Information System (INIS)

Zirker, J.B.

1977-01-01

Coronal holes low have been identified as Bartel's M regions, i.e., sources of high-speed wind streams that produce recurrent geomagnetic variations. Throughout the Skylab period the polar caps of the Sun were coronal holes, and at lower latitudes the most persistent and recurrent holes were equatorial extensions of the polar caps. The holes rotated 'rigidly' at the equatorial synodic rate. They formed in regions of unipolar photospheric magnetic field, and their internal magnetic fields diverged rapidly with increasing distance from the sun. The geometry of the magnetic field in the inner corona seems to control both the physical properties of the holes and the global distribution of high-speed wind streams in the heliosphere. The latitude variation of the divergence of the coronal magnetic field lines produces corresponding variations in wind speed.During the years of declining solar activity the global field of the corona approximates a perturbed dipole. The divergence of field lines in each hemisphere produces a high-speed wind near the poles and low-speed wind in a narrow belt that coincides with the magnetic neutral sheet. The analysis of electron density measurements within a polar hole indicates that solar wind is accelerated principally in the region between 2 and 5 R/sub s/ and that mechanical wave pressure (possibly Alfven wave) may be responsible for the accleration of the wind. Phenomenological models for the birth and decay of coronal holes have been proposed. Attempts to explain the birth and rigid rotation of holes through dynamo action have been only partially successful. The 11-year variation of cosmic ray intensities at the earth may result from cyclic variation of open field regions associated with coronal holes

Whole-lesion ADC histogram and texture analysis in predicting recurrence of cervical cancer treated with CCRT.

Science.gov (United States)

Meng, Jie; Zhu, Lijing; Zhu, Li; Xie, Li; Wang, Huanhuan; Liu, Song; Yan, Jing; Liu, Baorui; Guan, Yue; He, Jian; Ge, Yun; Zhou, Zhengyang; Yang, Xiaofeng

2017-11-03

To explore the value of whole-lesion apparent diffusion coefficient (ADC) histogram and texture analysis in predicting tumor recurrence of advanced cervical cancer treated with concurrent chemo-radiotherapy (CCRT). 36 women with pathologically confirmed advanced cervical squamous carcinomas were enrolled in this prospective study. 3.0 T pelvic MR examinations including diffusion weighted imaging (b = 0, 800 s/mm 2 ) were performed before CCRT (pre-CCRT) and at the end of 2nd week of CCRT (mid-CCRT). ADC histogram and texture features were derived from the whole volume of cervical cancers. With a mean follow-up of 25 months (range, 11 ∼ 43), 10/36 (27.8%) patients ended with recurrence. Pre-CCRT 75th, 90th, correlation, autocorrelation and mid-CCRT ADC mean , 10th, 25th, 50th, 75th, 90th, autocorrelation can effectively differentiate the recurrence from nonrecurrence group with area under the curve ranging from 0.742 to 0.850 (P values range, 0.001 ∼ 0.038). Pre- and mid-treatment whole-lesion ADC histogram and texture analysis hold great potential in predicting tumor recurrence of advanced cervical cancer treated with CCRT.

TECHNICAL APPROACH TO THE EFFICIENCY DETERMINATION OF HIGH-SPEED TRAINS

Directory of Open Access Journals (Sweden)

A. V. Momot

2013-11-01

Full Text Available Purpose. The aim of this article is to develop an approach and formulate arrangements concerning the definition of the economic appropriateness of high-speed movement implementation in Ukraine. Methodology. The economic feasibility for appropriateness of high-speed movement organization in Ukraine is an investment project, which involves step-by-step money investment into the construction. It will let get an annual profits from the passenger carriage. To solve such problems we use net present value, which UZ or newly created companies can get during the project realization and after its completion. Findings. Obtained studies can state the fact that the technical approach for full effectiveness definition of a construction and high-speed passenger trains service taking into account the cost of infrastructure, rolling stock, the impact of environmental factors, etc. was determined. Originality. We propose a scientific approach to determine the economic effectiveness of the construction and high-speed main lines service. It includes improved principles of defining the passenger traffic, the cost of high-speed rails construction, the number of rolling stock; optimizes income and expenditure calculations in the context of competitive advantages and the external factors impact on the company. A technical approach for the calculation of future traffic volumes along the high-speed line was improved. It differs essentially from the European one proposed by the French firm «SYSTRA», as it allows taking into account additional transit traffic through Ukraine. It helps to distribute the passengers on separate sections proportionally to the number of cities population, which are combined by high-speed main line, subject to the average population mobility, travel time and the coefficient that takes into account the frequency of additional passenger trips on a given section, depending on the purpose (business trip, transfer to a plane, recreation, etc

High-speed motion neutron radiography

International Nuclear Information System (INIS)

Bossi, R.H.; Barton, J.P.; Robinson, A.H.

1982-01-01

A system has been developed to perform neutron radiographic analysis of dynamic events having a duration of several milliseconds. The system has been operated in the range of 2000 to 10,000 frames. Synchronization has provided high-speed motion neutron radiographs for evaluation of the firing cycles of 7.62-mm munition rounds within a thick steel rifle barrel. The system has also been used to demonstrate its ability to produce neutron radiographic movies of two-phase flow. The equipment includes a TRIGA reactor capable of pulsing to a peak power of 3000 MW, a neutron beam collimator, a scintillator neutron conversion screen coupled to an image intensifier, and a 16-mm high-speed movie camera. The peak neutron flux incident at the object position is about 4 X 10 11 n/cm 2 X s with a pulse, full-width at half-maximum, of 9 ms. Modulation transfer function techniques have been used to assist optimization of the system performance. Special studies have been performed on the scintillator conversion screens and on the effects of statistical limitations on information availability

The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer

Directory of Open Access Journals (Sweden)

Bedriye Koyuncu Sokmen

2017-12-01

Full Text Available Purpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. Methods: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study. Risk classification of patients were evaluated as low-risk (Group 1 (n = 20 (Stage T1c-T2a, PSA T3a, PSA > 20 ng/ml, Gleason Score > 7. Diffusion-weighted MR images, dynamic contrasted MR images, and ADC values of the prostates were correlated. Results: ADC values of the cases in Group 3 were lower than those of the other groups (p 0.05. Biological activity of the tumor tissue was determined by GS, while a negative correlation was observed between GSs and ADC values of the patients, (p < 0.001. Conclusion: In tumors with higher Gleason scores, lower ADC values were obtained. These measured values can play a role in the noninvasive determination of the cellularity of the tumoral mass.

Design Strategy for a Pipelined ADC Employing Digital Post-correction

NARCIS (Netherlands)

Harpe, P.J.A.; Zanikopoulos, A.; Hegt, J.A.; Roermund, van A.H.M.

2004-01-01

This paper describes how the usage of digital post-correction techniques in pipelined analog-to-digital converters (ADC's) can be exploited optimally during the design-phase of the converter. It is known that post-correction algorithms reduce the influence of several cir- cuit impairments on the

Algorithms for ADC multi-site test with digital input stimulus

NARCIS (Netherlands)

Sheng, Xiaoqin; Kerkhoff, Hans G.; Zjajo, Amir; Gronthoud, Guido

2009-01-01

This paper reports two novel algorithms based on time-modulo reconstruction method intended for detection of the parametric faults in analogue-to-digital converters (ADC). In both algorithms, a pulse signal, in its slightly adapted form to allow sufficient time for converter settling, is taken as

A High-Speed Train Operation Plan Inspection Simulation Model

Directory of Open Access Journals (Sweden)

Yang Rui

2018-01-01

Full Text Available We developed a train operation simulation tool to inspect a train operation plan. In applying an improved Petri Net, the train was regarded as a token, and the line and station were regarded as places, respectively, in accordance with the high-speed train operation characteristics and network function. Location change and running information transfer of the high-speed train were realized by customizing a variety of transitions. The model was built based on the concept of component combination, considering the random disturbance in the process of train running. The simulation framework can be generated quickly and the system operation can be completed according to the different test requirements and the required network data. We tested the simulation tool when used for the real-world Wuhan to Guangzhou high-speed line. The results showed that the proposed model can be developed, the simulation results basically coincide with the objective reality, and it can not only test the feasibility of the high-speed train operation plan, but also be used as a support model to develop the simulation platform with more capabilities.

High-Speed 3D Printing of High-Performance Thermosetting Polymers via Two-Stage Curing.

Science.gov (United States)

Kuang, Xiao; Zhao, Zeang; Chen, Kaijuan; Fang, Daining; Kang, Guozheng; Qi, Hang Jerry

2018-04-01

Design and direct fabrication of high-performance thermosets and composites via 3D printing are highly desirable in engineering applications. Most 3D printed thermosetting polymers to date suffer from poor mechanical properties and low printing speed. Here, a novel ink for high-speed 3D printing of high-performance epoxy thermosets via a two-stage curing approach is presented. The ink containing photocurable resin and thermally curable epoxy resin is used for the digital light processing (DLP) 3D printing. After printing, the part is thermally cured at elevated temperature to yield an interpenetrating polymer network epoxy composite, whose mechanical properties are comparable to engineering epoxy. The printing speed is accelerated by the continuous liquid interface production assisted DLP 3D printing method, achieving a printing speed as high as 216 mm h -1 . It is also demonstrated that 3D printing structural electronics can be achieved by combining the 3D printed epoxy composites with infilled silver ink in the hollow channels. The new 3D printing method via two-stage curing combines the attributes of outstanding printing speed, high resolution, low volume shrinkage, and excellent mechanical properties, and provides a new avenue to fabricate 3D thermosetting composites with excellent mechanical properties and high efficiency toward high-performance and functional applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Differentiation of benign and malignant lymph nodes with ADC value on diffusion MR: a Meta-analysis

International Nuclear Information System (INIS)

Long Miaomiao; Liu Lihua; Gao Guangfeng; Chen Lihua; Shen Wen; Qi Ji

2012-01-01

Objective: To summarize the diagnostic efficacy of ADC value for differentiation of benign and malignant lymph nodes on diffusion MRI with Meta-analysis. Methods: Published papers on differentiation of benign and malignant lymph nodes with ADC value were searched and reviewed. Quality evaluation was performed for the eligible papers before data extraction.Test for heterogeneity was performed first, then appropriate model was selected to calculate the weighted mean difference, sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio,pretest and posttest probability. The potential of ADC value for differentiation of benign and malignant lymph nodes was assessed qualitatively and quantitatively. Results: Fifteen papers including 735 cases and 1963 lymph nodes were selected. According to Meta-regression analysis, subgroup analysis and robust analysis, two studies with benign lymph nodes in patients with benign lesion and one study using chemical shift saturation technique were excluded because of their impact on the robustness of the pooled results. The weighted mean difference (WMD) between malignant and benign lymph nodes was -0.355 × 10 -3 mm 2 /s [95% confidence interval (CI):-0.423 ×10-3- -0.288 × 10 -3 mm 2 /s]. Although the cutoff of ADC value for differentiation in each study was different, the diagnostic efficacy was stable, the pooled sensitivity,specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under summarized receiver operator's curve were 0.87 (95% CI: 0.79-0.92), 0.87 (95% CI: 0.82-0.90), 6.5 (95% CI: 4.7-9.2), 0.15 (95% CI: 0.09-0.25), 43 (95% CI: 21-87), 0.93 (95% CI: 0.90-0.95). The posttest malignancy probability of benign lymph node indicated by ADC was 6%, while that of malignant lymph node was 72%. Conclusion: The ADC value can be used to differentiate benign and malignant lymph nodes with good sensitivity and specificity noninvasively. (authors)

High-speed imaging of blood splatter patterns

Energy Technology Data Exchange (ETDEWEB)

McDonald, T.E.; Albright, K.A.; King, N.S.P.; Yates, G.J. (Los Alamos National Lab., NM (United States)); Levine, G.F. (California Dept. of Justice, Sacramento, CA (United States). Bureau of Forensic Services)

1993-01-01

The interpretation of blood splatter patterns is an important element in reconstructing the events and circumstances of an accident or crime scene. Unfortunately, the interpretation of patterns and stains formed by blood droplets is not necessarily intuitive and study and analysis are required to arrive at a correct conclusion. A very useful tool in the study of blood splatter patterns is high-speed photography. Scientists at the Los Alamos National Laboratory, Department of Energy (DOE), and Bureau of Forensic Services, State of California, have assembled a high-speed imaging system designed to image blood splatter patterns. The camera employs technology developed by Los Alamos for the underground nuclear testing program and has also been used in a military mine detection program. The camera uses a solid-state CCD sensor operating at approximately 650 frames per second (75 MPixels per second) with a microchannel plate image intensifier that can provide shuttering as short as 5 ns. The images are captured with a laboratory high-speed digitizer and transferred to an IBM compatible PC for display and hard copy output for analysis. The imaging system is described in this paper.

High-speed imaging of blood splatter patterns

Energy Technology Data Exchange (ETDEWEB)

McDonald, T.E.; Albright, K.A.; King, N.S.P.; Yates, G.J. [Los Alamos National Lab., NM (United States); Levine, G.F. [California Dept. of Justice, Sacramento, CA (United States). Bureau of Forensic Services

1993-05-01

The interpretation of blood splatter patterns is an important element in reconstructing the events and circumstances of an accident or crime scene. Unfortunately, the interpretation of patterns and stains formed by blood droplets is not necessarily intuitive and study and analysis are required to arrive at a correct conclusion. A very useful tool in the study of blood splatter patterns is high-speed photography. Scientists at the Los Alamos National Laboratory, Department of Energy (DOE), and Bureau of Forensic Services, State of California, have assembled a high-speed imaging system designed to image blood splatter patterns. The camera employs technology developed by Los Alamos for the underground nuclear testing program and has also been used in a military mine detection program. The camera uses a solid-state CCD sensor operating at approximately 650 frames per second (75 MPixels per second) with a microchannel plate image intensifier that can provide shuttering as short as 5 ns. The images are captured with a laboratory high-speed digitizer and transferred to an IBM compatible PC for display and hard copy output for analysis. The imaging system is described in this paper.

High performance multi-channel high-speed I/O circuits

CERN Document Server

Oh, Taehyoun

2013-01-01

This book describes design techniques that can be used to mitigate crosstalk in high-speed I/O circuits. The focus of the book is in developing compact and low power integrated circuits for crosstalk cancellation, inter-symbol interference (ISI) mitigation and improved bit error rates (BER) at higher speeds. This book is one of the first to discuss in detail the problem of crosstalk and ISI mitigation encountered as data rates have continued beyond 10Gb/s. Readers will learn to avoid the data performance cliff, with circuits and design techniques described for novel, low power crosstalk cancel

A 10-bit 80-MS/s opamp-sharing pipelined ADC with a switch-embedded dual-input MDAC

Energy Technology Data Exchange (ETDEWEB)

Yin Rui; Zhang Wei; Tang Zhangwen [ASIC and System State Key Laboratory, Fudan University, Shanghai 201203 (China); Liao Youchun, E-mail: zwtang@fudan.edu.cn [Ratio Microelectronics Co., Ltd, Shanghai 200433 (China)

2011-02-15

A 10-bit 80-MS/s opamp-sharing pipelined ADC is implemented in a 0.18-{mu}m CMOS. An opamp-sharing MDAC with a switch-embedded dual-input opamp is proposed to eliminate the non-resetting and successive-stage crosstalk problems observed in the conventional opamp-sharing technique. The ADC achieves a peak SNDR of 60.1 dB (ENOB = 9.69 bits) and a peak SFDR of 76 dB, while maintaining more than 9.6 ENOB for the full Nyquist input bandwidth. The core area of the ADC is 1.1 mm{sup 2} and the chip consumes 28 mW with a 1.8 V power supply. (semiconductor integrated circuits)

Comparative study of the sensitivity of ADC value and T2 relaxation time for early detection of Wallerian degeneration

International Nuclear Information System (INIS)

Zhang Fan; Lu Guangming; Zee Chishing

2011-01-01

Background and purpose: Wallerian degeneration (WD), the secondary degeneration of axons from cortical and subcortical injuries, is associated with poor neurological outcome. There is some quantitative MR imaging techniques used to estimate the biologic changes secondary to delayed neuronal and axonal losses. Our purpose is to assess the sensitivity of ADC value and T 2 relaxation time for early detection of WD. Methods: Ten male Sprague-Dawley rats were used to establish in vivo Wallerian degeneration model of CNS by ipsilateral motor-sensory cortex ablation. 5 days after cortex ablation, multiecho-T 2 relaxometry and multi-b value DWI were acquired by using a 7 T MR imaging scanner. ADC-map and T 2 -map were reconstructed by post-processing. ROIs are selected according to pathway of corticospinal tract from cortex, internal capsule, cerebral peduncle, pons, medulla oblongata to upper cervical spinal cord to measure ADC value and T 2 relaxation time of healthy side and affected side. The results were compared between the side with cortical ablation and the side without ablation. Results: Excluding ablated cortex, ADC values of the corticospinal tract were significantly increased (P 2 relaxation time was observed between the affected and healthy sides. Imaging findings were correlated with histological examinations. Conclusion: As shown in this animal experiment, ADC values could non-invasively demonstrate the secondary degeneration involving descending white matter tracts. ADC values are more sensitive indicators for detection of early WD than T 2 relaxation time.

High-speed photography of light beams transmitted through pinhole targets

International Nuclear Information System (INIS)

Yaonan, D.; Haien, He.; Lian, C.; Huifang, Z.; Zhijian, Z.

1988-01-01

A method of high speed photography is presented. It was designed and performed in order to study temporal behaviors of plasma closure effects of pinhole targets in laser plasma experiments. A series of high speed photographs were taken for the laser beam transmitted through the pinhole targets. Spatially resolved and integrated temporal histories of closure effects were observed, respectively. Some physical information about closure effect and closure speed have been studied

A high sensitivity 20Mfps CMOS image sensor with readout speed of 1Tpixel/sec for visualization of ultra-high speed phenomena

Science.gov (United States)

Kuroda, R.; Sugawa, S.

2017-02-01

Ultra-high speed (UHS) CMOS image sensors with on-chop analog memories placed on the periphery of pixel array for the visualization of UHS phenomena are overviewed in this paper. The developed UHS CMOS image sensors consist of 400H×256V pixels and 128 memories/pixel, and the readout speed of 1Tpixel/sec is obtained, leading to 10 Mfps full resolution video capturing with consecutive 128 frames, and 20 Mfps half resolution video capturing with consecutive 256 frames. The first development model has been employed in the high speed video camera and put in practical use in 2012. By the development of dedicated process technologies, photosensitivity improvement and power consumption reduction were simultaneously achieved, and the performance improved version has been utilized in the commercialized high-speed video camera since 2015 that offers 10 Mfps with ISO16,000 photosensitivity. Due to the improved photosensitivity, clear images can be captured and analyzed even under low light condition, such as under a microscope as well as capturing of UHS light emission phenomena.

Vibration characteristics of dental high-speed turbines and speed-increasing handpieces.

Science.gov (United States)

Poole, Ruth L; Lea, Simon C; Dyson, John E; Shortall, Adrian C C; Walmsley, A Damien

2008-07-01

Vibrations of dental handpieces may contribute to symptoms of hand-arm vibration syndrome in dental personnel and iatrogenic enamel cracking in teeth. However, methods for measuring dental handpiece vibrations have previously been limited and information about vibration characteristics is sparse. This preliminary study aimed to use a novel approach to assess the vibrations of unloaded high-speed handpieces in vitro. Maximum vibration displacement amplitudes of five air turbines and two speed-increasing handpieces were recorded whilst they were operated with and without a rotary cutting instrument (RCI) using a scanning laser vibrometer (SLV). RCI rotation speeds, calculated from frequency peaks, were consistent with expected values. ANOVA statistical analysis indicated significant differences in vibrations between handpiece models (p0.11). Operating handpieces with a RCI resulted in greater vibrations than with no RCI (pmeasurement exceeded 4 microm for the handpieces in the current test setup (implying that these vibrations may be unlikely to cause adverse effects), this study has formed the basis for future work which will include handpiece vibration measurements whilst cutting under clinically representative loads.

Exploring dynamics of embedded ADC through adapted digital input stimuli

NARCIS (Netherlands)

Sheng, Xiaoqin; Kerkhoff, Hans G.; Zjajo, A.; Gronthoud, G.

2008-01-01

This paper reports an evaluation of adapted digital signals as a test stimulus to test dynamic parameters of analog-to-digital converters (ADC). In the first instance, the simplest digital waveform, a pulse signal, is taken as the test stimulus. The dynamics of the device under test while applying

Diagnostic value of diffusion weighted MRI and ADC in differential ...

African Journals Online (AJOL)

Ankara Oncology Training and Research Hospital, Department of Radiology, Ankara/Turkey. 2. ... created and ADC values were measured for 72 liver masses and normal liver tissue (control group). ... ing MR gradient strength and duration) (b=400-1000 .... (B) Fat suppressed T1 weighted image after IV contrast showing.

Liquid metal current collectors for high-speed rotating machinery

International Nuclear Information System (INIS)

Carr, S.L.

1976-01-01

Recent interest in superconducting motors and generators has created a renewed interest in homopolar machinery. Homopolar machine designs have always been limited by the need for compact, high-current, low-voltage, sliding electrical curent collectors. Conventional graphite-based solid brushes are inadequate for use in homopolar machines. Liquid metals, under certain conditions of relative sliding velocities, electrical currents, and magnetic fields are known to be capable of performing well in homopolar machines. An effort to explore the capabilities and limits of a tongue-and-groove style current collector, utilizing sodium-potassium eutectic alloy (NaK) as the working fluid in high sliding speed operation is reported here. A double current collector generator model with a 14.5-cm maximum rotor diameter, 20,000 rpm rotational capability, and electrical current carrying ability was constructed and operated successfully at a peripheral velocity of 125 m/s. The limiting factor in these experiments was a high-speed fluid-flow instability resulting in the ejection of the working fluid from the operating portions of the collectors. The effects of collector size and geometry, working fluid (NaK or water), and cover gas pressure are reported. Hydrodynamic frictional torque-speed curves are given for the two fluids and for several geometries. Electrical resistances as a function of peripheral velocity at 60 amperes are reported, and the phenomenology of the high-speed fluid-flow instabilities is discussed. The possibility of long-term high-speed operation of current collectors of the tongue-and-groove type, along with experimental and theoretical hydrodynamic friction losses at high peripheral velocities, is considered

High-speed measurement of firearm primer blast waves

OpenAIRE

Courtney, Michael; Daviscourt, Joshua; Eng, Jonathan; Courtney, Amy

2012-01-01

This article describes a method and results for direct high-speed measurements of firearm primer blast waves employing a high-speed pressure transducer located at the muzzle to record the blast pressure wave produced by primer ignition. Key findings are: 1) Most of the lead styphnate based primer models tested show 5.2-11.3% standard deviation in the magnitudes of their peak pressure. 2) In contrast, lead-free diazodinitrophenol (DDNP) based primers had standard deviations of the peak blast p...

Rad-Hard Sigma-Delta 3-channel ADC for Fluxgate Magnetometers, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The proposed project aims to develop a multi-channel analog to digital converter (ADC) required for a fluxgate magnetometer (EPD) employed on NASA's planetary...

Low-Speed Stability-and-Control and Ground-Effects Measurements on the Industry Reference High Speed Civil Transport

Science.gov (United States)

Kemmerly, Guy T.; Campbell, Bryan A.; Banks, Daniel W.; Yaros, Steven F.

1999-01-01

As a part of a national effort to develop an economically feasible High Speed Civil Transport (HSCT), a single configuration has been accepted as the testing baseline by the organizations working in the High Speed Research (HSR) program. The configuration is based on a design developed by the Boeing Company and is referred to as the Reference H (Ref H). The data contained in this report are low-speed stability-and-control and ground-effect measurements obtained on a 0.06 scale model of the Ref H in a subsonic tunnel.

Successive approximation analog to digital conversion system with good differential linearity

Energy Technology Data Exchange (ETDEWEB)

Carter, D E; Randers-Pehrson, G [Ohio Univ., Athens (USA). Dept. of Physics

1982-08-15

A high speed modified successive approximation 4 input ADC system has been designed and constructed. Throughput rates of 250 kHz at 12 bit conversion gain with good differential linearity is achieved at low cost, using the MPX4 ADC system.

Nickel/Diamond Composite Coating Prepared by High Speed Electrodeposition

Directory of Open Access Journals (Sweden)

ZHANG Yan

2016-10-01

Full Text Available Nickel/diamond composite coatings were prepared on the basis of a new high speed electroplating bath. The influence of additives, plating parameters and diamond concentration on internal stress was investigated in order to find the solution to decrease the stress introduced by high current density; the micro morphology of the coatings were observed by SEM. The bath and depositing parameters were optimized that thick nickel/diamond composite coatings with low internal stress can be high speed electroplated with a high cathode current density of 30A/dm2. The results show that when plated with bath composition and parameters as follows: sodium dodecyl sulfate 0.5g/L, ammonium acetate 3g/L, sodium citrate 1.5g/L, diamond particles 30g/L; pH value 3-4, temperature 50℃, the composite coatings prepared in high speed have the lowest internal stress.

Surface grinding characteristics of ferrous metals under high-speed and speed-stroke grinding conditions

International Nuclear Information System (INIS)

Ghani, A.K.; Choudhury, I.A.; Ahim, M.B.

1999-01-01

Some ferrous metals have been ground under different conditions with high-speed and speed-stroke in surface grinding operation. The paper describes experimental investigation of grinding forces in grinding some ferrous metals with the application of cutting fluids. Grinding tests have been carried out on mild steel, assab steel and stainless steel with different combinations of down feed and cross feed. The wheel speed was 27 m/sec while the table speed was maintained at the maximum possible 25 m/min. The grindability has been evaluated by measuring the grinding forces, grinding ratio, and surface finish. Grinding forces have been plotted against down feed of the grinding wheel and cross feed of the table. It has been observed that the radial and tangential grinding forces in stainless steel were higher than those in assab steel and mild steel

Timing and control requirements for a 32-channel AMU-ADC ASIC for the PHENIX detector

International Nuclear Information System (INIS)

Emery, M.S.; Ericson, M.N.; Britton, C.L. Jr.

1998-01-01

A custom CMOS Application Specific Integrated Circuit (ASIC) has been developed consisting of an analog memory unit (AMU) has been developed consisting of an analog memory unit (AMU) and analog to digital converter (ADC), both of which have been designed for applications in the PHENIX experiment. This IC consists of 32 pipes of analog memory with 64 cells per pipe. Each pipe also has its own ADC channel. Timing and control signal requirements for optimum performance are discussed in this paper

High-speed optical feeder-link system using adaptive optics

Science.gov (United States)

Arimoto, Yoshinori; Hayano, Yutaka; Klaus, Werner

1997-05-01

We propose a satellite laser communication system between a ground station and a geostationary satellite, named high- speed optical feeder link system. It is based on the application of (a) high-speed optical devices, which have been developed for ground-based high-speed fiber-optic communications, and (b) the adaptive optics which compensates wavefront distortions due to atmospheric turbulences using a real time feedback control. A link budget study shows that a system with 10-Gbps bit-rate are available assuming the state-of-the-art device performance of the Er-doped fiber amplifier. We further discuss preliminary measurement results of the atmospheric turbulence at the telescope site in Tokyo, and present current study on the design of the key components for the feeder-link laser transceiver.

A high current, high speed pulser using avalanche transistors

International Nuclear Information System (INIS)

Hosono, Yoneichi; Hasegawa, Ken-ichi

1985-01-01

A high current, high speed pulser for the beam pulsing of a linear accelerator is described. It uses seven avalanche transistors in cascade. Design of a trigger circuit to obtain fast rise time is discussed. The characteristics of the pulser are : (a) Rise time = 0.9 ns (FWHM) and (d) Life time asymptotically equals 2000 -- 3000 hr (at 50 Hz). (author)

High Speed SPM of Functional Materials

Energy Technology Data Exchange (ETDEWEB)

Huey, Bryan D. [Univ. of Connecticut, Storrs, CT (United States)

2015-08-14

The development and optimization of applications comprising functional materials necessitates a thorough understanding of their static and dynamic properties and performance at the nanoscale. Leveraging High Speed SPM and concepts enabled by it, efficient measurements and maps with nanoscale and nanosecond temporal resolution are uniquely feasible. This includes recent enhancements for topographic, conductivity, ferroelectric, and piezoelectric properties as originally proposed, as well as newly developed methods or improvements to AFM-based mechanical, friction, thermal, and photoconductivity measurements. The results of this work reveal fundamental mechanisms of operation, and suggest new approaches for improving the ultimate speed and/or efficiency, of data storage systems, magnetic-electric sensors, and solar cells.

75 FR 16552 - High-Speed Intercity Passenger Rail (HSIPR) Program

Science.gov (United States)

2010-04-01

...; Enhancing intercity travel options; Ensuring a state of good repair of key intercity passenger rail assets... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration High-Speed Intercity Passenger Rail... selections for the High-Speed Intercity Passenger Rail (HSIPR) Program. This notice builds on the program...

High speed printing with polygon scan heads

Science.gov (United States)

Stutz, Glenn

2016-03-01

To reduce and in many cases eliminate the costs associated with high volume printing of consumer and industrial products, this paper investigates and validates the use of the new generation of high speed pulse on demand (POD) lasers in concert with high speed (HS) polygon scan heads (PSH). Associated costs include consumables such as printing ink and nozzles, provisioning labor, maintenance and repair expense as well as reduction of printing lines due to high through put. Targets that are applicable and investigated include direct printing on plastics, printing on paper/cardboard as well as printing on labels. Market segments would include consumer products (CPG), medical and pharmaceutical products, universal ID (UID), and industrial products. In regards to the POD lasers employed, the wavelengths include UV(355nm), Green (532nm) and IR (1064nm) operating within the repetition range of 180 to 250 KHz.

Development of Industrial High-Speed Transfer Parallel Robot

International Nuclear Information System (INIS)

Kim, Byung In; Kyung, Jin Ho; Do, Hyun Min; Jo, Sang Hyun

2013-01-01

Parallel robots used in industry require high stiffness or high speed because of their structural characteristics. Nowadays, the importance of rapid transportation has increased in the distribution industry. In this light, an industrial parallel robot has been developed for high-speed transfer. The developed parallel robot can handle a maximum payload of 3 kg. For a payload of 0.1 kg, the trajectory cycle time is 0.3 s (come and go), and the maximum velocity is 4.5 m/s (pick amp, place work, adept cycle). In this motion, its maximum acceleration is very high and reaches approximately 13g. In this paper, the design, analysis, and performance test results of the developed parallel robot system are introduced

Integrated High-Speed Torque Control System for a Robotic Joint

Science.gov (United States)

Davis, Donald R. (Inventor); Radford, Nicolaus A. (Inventor); Permenter, Frank Noble (Inventor); Valvo, Michael C. (Inventor); Askew, R. Scott (Inventor)

2013-01-01

A control system for achieving high-speed torque for a joint of a robot includes a printed circuit board assembly (PCBA) having a collocated joint processor and high-speed communication bus. The PCBA may also include a power inverter module (PIM) and local sensor conditioning electronics (SCE) for processing sensor data from one or more motor position sensors. Torque control of a motor of the joint is provided via the PCBA as a high-speed torque loop. Each joint processor may be embedded within or collocated with the robotic joint being controlled. Collocation of the joint processor, PIM, and high-speed bus may increase noise immunity of the control system, and the localized processing of sensor data from the joint motor at the joint level may minimize bus cabling to and from each control node. The joint processor may include a field programmable gate array (FPGA).

High speed data transmission at the Superconducting Super Collider

International Nuclear Information System (INIS)

Leskovar, B.

1990-04-01

High speed data transmission using fiber optics in the data acquisition system of the Superconducting Super Collider has been investigated. Emphasis is placed on the high speed data transmission system overview, the local data network and on subassemblies, such as optical transmitters and receivers. Also, the performance of candidate subassemblies having a low power dissipation for the data acquisition system is discussed. 14 refs., 5 figs

Measurement Research of Motorized Spindle Dynamic Stiffness under High Speed Rotating

Directory of Open Access Journals (Sweden)

Xiaopeng Wang

2015-01-01

Full Text Available High speed motorized spindle has become a key functional unit of high speed machine tools and effectively promotes the development of machine tool technology. The development of higher speed and more power puts forward the stricter requirement for the performance of motorized spindle, especially the dynamic performance which affects the machining accuracy, reliability, and production efficiency. To overcome the problems of ineffective loading and dynamic performance measurement of motorized spindle, a noncontact electromagnetic loading device is developed. The cutting load can be simulated by using electromagnetic force. A new method of measuring force by force sensors is presented, and the steady and transient loading force could be measured exactly. After the high speed machine spindle is tested, the frequency response curves of the spindle relative to machine table are collected at 0~12000 rpm; then the relationships between stiffness and speeds as well as between damping ratio and speeds are obtained. The result shows that not only the static and dynamic stiffness but also the damping ratio declined with the increase of speed.

Design and application on experimental platform for high-speed bearing with grease lubrication

Directory of Open Access Journals (Sweden)

He Qiang

2015-12-01

Full Text Available The experimental platform for high-speed grease is an important tool for research and development of high-speed motorized spindle with grease lubrication. In this article, the experimental platform for high-speed grease is designed and manufactured which consists of the drive system, the test portion, the loading system, the lubrication system, the control system, and so on. In the meantime, the high-speed angular contact ceramic ball bearings B7005C/HQ1P4 as the research object are tested and contrasted in the grease lubrication and oil mist lubrication. The experimental platform performance is validated by contrast experiment, and the high-speed lubricated bearing performance is also studied especially in the relationship among the rotating speed,load and temperature rise. The results show that the experimental platform works steadily, accurate, and reliable in the experimental testing. And the grease lubrication ceramic ball bearings B7005C/HQ1P4 can be used in high-speed motorized spindle in the circular water cooling conditions when the rotating speed is lower than 40,000 r/min or the DN value (the value of the bearing diameter times the rotating speed is lower than the 1.44 × 106 mm r/min. Grease lubrication instead of oil mist lubrication under high-speed rotating will simplify the structure design of the high-speed motorized spindle and reduce the pollution to the environment.

A 10MS/s 8-bit charge-redistribution ADC for hybrid pixel applications in 65m CMOS

CERN Document Server

Kishishita, T; Krüger, H; Koch, M; Germic, L; Wermes, N

2013-01-01

The design and measurement results of an 8-bit SAR ADC, based on a charge-redistribution DAC, are presented. This ADC is characterized by superior power efficiency and small area, realized by employing a lateral metal–metal capacitor array and a dynamic two-stage comparator. To avoid the need for a highspeed clock and its associated power consumption, an asynchronous logic was implemented in a logic control cell. A test chip has been developed in a 65 nm CMOS technology, including eight ADC channels with different layout flavors of the capacitor array, a transimpedance amplifier as a signal input structure, a serializer, and a custom-made LVDS driver for data transmission. The integral (INL) and differential (DNL) nonlinearities are measured below 0.5 LSB and 0.8 LSB, respectively, for the best channel operating at a sampling frequency of 10 MS/s. The area occupies 40 μm 70 μm for one ADC channel. The power consumption is estimated as 4 μW at 1 MS/s and 38 μW at 10 MS/s with a supply rail of 1.2 V. Th...

Automatic in-process chatter avoidance in the high-speed milling process

NARCIS (Netherlands)

Dijk, van N.J.M.; Doppenberg, E.J.J.; Faassen, R.P.H.; Wouw, van de N.; Oosterling, J.A.J.; Nijmeijer, H.

2010-01-01

High-speed milling is often used in industry to maximize productivity of the manufacturing of high-technology components, such as aeronautical components, mold, and dies. The occurrence of chatter highly limits the efficiency and accuracy of high-speed milling operations. In this paper, two control

Benefits of sequential turbocharging in improving high torque/low speed operation of medium speed diesel engines

Energy Technology Data Exchange (ETDEWEB)

Danyluk, P.; Gutoski, G. [Coltec Industries Inc., Fairbanks Morse Engine Division (United States); Chen, S.K. [PEI Consultants (United States)

1998-12-31

This paper describes the benefits of sequential turbocharging in improving the operating envelope of a medium speed diesel engine. In particular, the high torque, low speed performance envelope can be greatly extended over that of a standard medium speed engine and, in addition, can offer improved operating range over what has been achieved with compressor air bypass/waste gate systems. This paper compares the three approaches on the basis of possible operating envelopes for a specific application, the new U.S. Navy LPD-17 amphibious assault ship, which has a very demanding requirement for high torque at low engine speed and low ambient temperatures. Comparison is made to the earlier approach to extend the operating envelope on the U.S. Navy LSD-41 class engines. The LSD-41 fleet has been in service since 1985 running with a compressor air bypass system developed jointly by Lockheed Shipyard and Coltec Industries for the U.S. Navy. (au)

High Resolution, High-Speed Photography, an Increasingly Prominent Diagnostic in Ballistic Research Experiments

International Nuclear Information System (INIS)

Shaw, L.; Muelder, S.

1999-01-01

High resolution, high-speed photography is becoming a prominent diagnostic in ballistic experimentation. The development of high speed cameras utilizing electro-optics and the use of lasers for illumination now provide the capability to routinely obtain high quality photographic records of ballistic style experiments. The purpose of this presentation is to review in a visual manner the progress of this technology and how it has impacted ballistic experimentation. Within the framework of development at LLNL, we look at the recent history of large format high-speed photography, and present a number of photographic records that represent the state of the art at the time they were made. These records are primarily from experiments involving shaped charges. We also present some examples of current photographic technology, developed within the ballistic community, that has application to hydro diagnostic experimentation at large. This paper is designed primarily as an oral-visual presentation. This written portion is to provide general background, a few examples, and a bibliography

Acoustic grating fringe projector for high-speed and high-precision three-dimensional shape measurements

International Nuclear Information System (INIS)

Yin Xuebing; Zhao Huijie; Zeng Junyu; Qu Yufu

2007-01-01

A new acoustic grating fringe projector (AGFP) was developed for high-speed and high-precision 3D measurement. A new acoustic grating fringe projection theory is also proposed to describe the optical system. The AGFP instrument can adjust the spatial phase and period of fringes with unprecedented speed and accuracy. Using rf power proportional-integral-derivative (PID) control and CCD synchronous control, we obtain fringes with fine sinusoidal characteristics and realize high-speed acquisition of image data. Using the device, we obtained a precise phase map for a 3D profile. In addition, the AGFP can work in running fringe mode, which could be applied in other measurement fields

HDR 192Ir source speed measurements using a high speed video camera

International Nuclear Information System (INIS)

Fonseca, Gabriel P.; Viana, Rodrigo S. S.; Yoriyaz, Hélio; Podesta, Mark; Rubo, Rodrigo A.; Sales, Camila P. de; Reniers, Brigitte; Verhaegen, Frank

2015-01-01

Purpose: The dose delivered with a HDR 192 Ir afterloader can be separated into a dwell component, and a transit component resulting from the source movement. The transit component is directly dependent on the source speed profile and it is the goal of this study to measure accurate source speed profiles. Methods: A high speed video camera was used to record the movement of a 192 Ir source (Nucletron, an Elekta company, Stockholm, Sweden) for interdwell distances of 0.25–5 cm with dwell times of 0.1, 1, and 2 s. Transit dose distributions were calculated using a Monte Carlo code simulating the source movement. Results: The source stops at each dwell position oscillating around the desired position for a duration up to (0.026 ± 0.005) s. The source speed profile shows variations between 0 and 81 cm/s with average speed of ∼33 cm/s for most of the interdwell distances. The source stops for up to (0.005 ± 0.001) s at nonprogrammed positions in between two programmed dwell positions. The dwell time correction applied by the manufacturer compensates the transit dose between the dwell positions leading to a maximum overdose of 41 mGy for the considered cases and assuming an air-kerma strength of 48 000 U. The transit dose component is not uniformly distributed leading to over and underdoses, which is within 1.4% for commonly prescribed doses (3–10 Gy). Conclusions: The source maintains its speed even for the short interdwell distances. Dose variations due to the transit dose component are much lower than the prescribed treatment doses for brachytherapy, although transit dose component should be evaluated individually for clinical cases

Assessment of left ventricular hemodynamics by Gd-DTPA enhanced high speed cine MRI

International Nuclear Information System (INIS)

Matsumura, Kentaro; Nakase, Emiko; Kawai, Ichiro

1992-01-01

To assess the validity of Gd-DTPA enhanced high speed cine MRI in left ventricular (LV) volumes and ejection fraction (EF), high speed cine MRI was compared with intra-venous digital subtraction left ventriculography (IV-DSA) in 14 patients. All patients underwent conventional cine MRI and Gd-DTPA enhanced high speed MRI, simultaneously. The pulse sequences of high speed MRI were TR 8 ms (TR 6 ms plus rewind pulse 2 ms), TE 3.2 ms, matrix 128, phase encode 8 or 6 and NEX 1. Comparison with LV-volume showed a high correlation (y = 0.854x + 1,699, r = 0.985) between high speed cine MRI and VI-DSA. To make left ventricular volume curve by area-length method in cine MRI, manual tracing of LV-cavity was more difficult in conventional cine MRI-method than enhanced high speed cine MRI-method. In conclusion, first pass-Gd-DTPA enhanced high speed cine MRI, using the horizontal long axis approach and the multiphase study, is a highly, accurate reproducible method of evaluating LV-volumetry. (author)

Architecture Of High Speed Image Processing System

Science.gov (United States)

Konishi, Toshio; Hayashi, Hiroshi; Ohki, Tohru

1988-01-01

One of architectures for a high speed image processing system which corresponds to a new algorithm for a shape understanding is proposed. And the hardware system which is based on the archtecture was developed. Consideration points of the architecture are mainly that using processors should match with the processing sequence of the target image and that the developed system should be used practically in an industry. As the result, it was possible to perform each processing at a speed of 80 nano-seconds a pixel.

Nanocrystalline Ni-Co Alloy Synthesis by High Speed Electrodeposition

OpenAIRE

Idris, Jamaliah; Christian, Chukwuekezie; Gaius, Eyu

2013-01-01

Electrodeposition of nanocrystals is economically and technologically viable production path for the synthesis of pure metals and alloys both in coatings and bulk form. The study presents nanocrystalline Ni-Co alloy synthesis by high speed electrodeposition. Nanocrystalline Ni-Co alloys coatings were prepared by direct current (DC) and deposited directly on steel and aluminum substrates without any pretreatment, using high speed electrodeposition method. The influence of the electrolysis par...

A new method for reducing DNL in nuclear ADCs using an interpolation technique

International Nuclear Information System (INIS)

Vaidya, P.P.; Gopalakrishnan, K.R.; Pethe, V.A.; Anjaneyulu, T.

1986-01-01

The paper describes a new method for reducing the DNL associated with nuclear ADCs. The method named the ''interpolation technique'' is utilized to derive the quantisation steps corresponding to the last n bits of the digital code by dividing quantisation steps due to higher significant bits of the DAC, using a chain of resistors. Using comparators, these quantisation steps are compared with the analog voltage to be digitized, which is applied as a voltage shift at both ends of this chain. The output states of the comparators define the n bit code. The errors due to offset voltages and bias currents of the comparators are statistically neutralized by changing the polarity of quantisation steps as well as the polarity of analog voltage (corresponding to last n bits) for alternate A/D conversion. The effect of averaging on the channel profile can be minimized. A 12 bit ADC was constructured using this technique which gives DNL of less than +-1% over most of the channels for conversion time of nearly 4.5 μs. Gatti's sliding scale technique can be implemented for further reduction of DNL. The interpolation technique has a promising potential of improving the resolution of existing 12 bit ADCs to 16 bit, without degrading the percentage DNL significantly. (orig.)

High-speed cell recognition algorithm for ultrafast flow cytometer imaging system

Science.gov (United States)

Zhao, Wanyue; Wang, Chao; Chen, Hongwei; Chen, Minghua; Yang, Sigang

2018-04-01

An optical time-stretch flow imaging system enables high-throughput examination of cells/particles with unprecedented high speed and resolution. A significant amount of raw image data is produced. A high-speed cell recognition algorithm is, therefore, highly demanded to analyze large amounts of data efficiently. A high-speed cell recognition algorithm consisting of two-stage cascaded detection and Gaussian mixture model (GMM) classification is proposed. The first stage of detection extracts cell regions. The second stage integrates distance transform and the watershed algorithm to separate clustered cells. Finally, the cells detected are classified by GMM. We compared the performance of our algorithm with support vector machine. Results show that our algorithm increases the running speed by over 150% without sacrificing the recognition accuracy. This algorithm provides a promising solution for high-throughput and automated cell imaging and classification in the ultrafast flow cytometer imaging platform.

Dynamic changes in water ADC, energy metabolism, extracellular space volume and tortuosity in neonatal rat brain during irreversible ischemia

NARCIS (Netherlands)

Toorn, van der A.; Syková, E.; Dijkhuizen, R.M.; Voríšek, I.; Vargová, L.; Skobisová, E.; Lookeren Campagne, van M.; Reese, T.; Nicolaij, K.

1996-01-01

To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac

Development of a Multichannel Analyzer for modular ADCs

International Nuclear Information System (INIS)

Bannos Rodriguez, U.; Diaz Castro, M.; Rivero Ramirez, D.

2013-01-01

This paper describes the design and construction of a multichannel analyzer with USB interface from ADC module of the Fast ComTec 7074. One PIC18F4550 microprocessor from Microchip, one CPLD isPLSI 1032E from Lattice and one 32Kx8 SRAM memory were used. It also includes details of the programming circuitry and development of program acquisition, storage and display of the spectra using the Qt libraries. Finally, preliminary tests to the device are show. (Author)

Stability control for high speed tracked unmanned vehicles

Science.gov (United States)

Pape, Olivier; Morillon, Joel G.; Houbloup, Philippe; Leveque, Stephane; Fialaire, Cecile; Gauthier, Thierry; Ropars, Patrice

2005-05-01

The French Military Robotic Study Program (introduced in Aerosense 2003), sponsored by the French Defense Procurement Agency and managed by Thales as the prime contractor, focuses on about 15 robotic themes which can provide an immediate "operational add-on value". The paper details the "automatic speed adjustment" behavior (named SYR4), developed by Giat Industries Company, which main goal is to secure the teleoperated mobility of high speed tracked vehicles on rough grounds; more precisely, the validated low level behavior continuously adjusts the vehicle speed taking into account the teleperator wish AND the maximum speed that the vehicle can manage safely according to the commanded radius of curvature. The algorithm is based on a realistic physical model of the ground-tracks relation, taking into account many vehicle and ground parameters (such as ground adherence and dynamic specificities of tracked vehicles). It also deals with the teleoperator-machine interface, providing a balanced strategy between both extreme behaviors: a) maximum speed reduction before initiating the commanded curve; b) executing the minimum possible radius without decreasing the commanded speed. The paper presents the results got from the military acceptance tests performed on tracked SYRANO vehicle (French Operational Demonstrator).

High speed motion-picture photography. Instrumentation and application

International Nuclear Information System (INIS)

Bertin-Maghit, G.; Delli, C.; Falgayrettes, M.

1981-01-01

Filming technology at 5,000 frames/second is presented in this paper for the determination of the volume and the expension speed of a gas bubble in water. The high speed 16 mm movie camera, fitted with ultra-wide angle lenses, is placed in front of a side light facing the bubble. Ten 60 ms fast flashes, released in succession, illuminate the bubble [fr

CERNET - A high-speed packet-switching network

International Nuclear Information System (INIS)

Gerard, J.M.

1981-01-01

A general mesh-structured high-speed computer network has been designed and built. This network provides communication between any pair of connected user computers over distances of upto 6 km and at line speeds of 1 to 5 Mbit/second. The network is composed of a communication subnet providing a datagram service, complemented by tasks in the connected machines to implement an end-to-end logical link protocol. Details are given of the overall structure as well as the specific modules of which the system is composed. (orig.)

Cavitation performance improvement of high specific speed mixed-flow pump

International Nuclear Information System (INIS)

Chen, T; Sun, Y B; Wu, D Z; Wang, L Q

2012-01-01

Cavitation performance improvement of large hydraulic machinery such as pump and turbine has been a hot topic for decades. During the design process of the pumps, in order to minimize size, weight and cost centrifugal and mixed-flow pump impellers are required to operate at the highest possible rotational speed. The rotational speed is limited by the phenomenon of cavitation. The hydraulic model of high-speed mixed-flow pump with large flow rate and high pumping head, which was designed based on the traditional method, always involves poor cavitation performance. In this paper, on the basis of the same hydraulic design parameters, two hydraulic models of high-speed mixed-flow pump were designed by using different methods, in order to investigate the cavitation and hydraulic performance of the two models, the method of computational fluid dynamics (CFD) was adopted for internal flow simulation of the high specific speed mixed-flow pump. Based on the results of numerical simulation, the influences of impeller parameters and three-dimensional configuration on pressure distribution of the blades' suction surfaces were analyzed. The numerical simulation results shows a better pressure distribution and lower pressure drop around the leading edge of the improved model. The research results could provide references to the design and optimization of the anti-cavitation blade.

Microprocessor controlled dual parameter ADC system with a CAMAC interface

Energy Technology Data Exchange (ETDEWEB)

Perry, D G; Nickell, Jr, J D [Los Alamos Scientific Lab., NM (USA)

1978-09-01

Presented here is the design of a dual parameter ADC system which is controlled by a microprocessor and also interfaced to CAMAC. The system was designed to be mobile in that it may work wherever there is a CAMAC crate. In such cases where the CAMAC system is inoperative, the system may operate in a stand-alone mode.

The value of whole lesion ADC histogram profiling to differentiate between morphologically indistinguishable ring enhancing lesions–comparison of glioblastomas and brain abscesses

Science.gov (United States)

Hoffmann, Karl-Titus; Garnov, Nikita; Vörkel, Cathrin; Kohlhof-Meinecke, Patricia; Ganslandt, Oliver; Bäzner, Hansjörg; Gihr, Georg Alexander; Kalman, Marcell; Henkes, Elina; Henkes, Hans; Schob, Stefan

2018-01-01

Background Morphologically similar appearing ring enhancing lesions in the brain parenchyma can be caused by a number of distinct pathologies, however, they consistently represent life-threatening conditions. The two most frequently encountered diseases manifesting as such are glioblastoma multiforme (GBM) and brain abscess (BA), each requiring disparate therapeutical approaches. As a result of their morphological resemblance, essential treatment might be significantly delayed or even ommited, in case results of conventional imaging remain inconclusive. Therefore, our study aimed to investigate, whether ADC histogram profiling reliably can distinguish between both entities, thus enhancing the differential diagnostic process and preventing treatment failure in this highly critical context. Methods 103 patients (51 BA, 52 GBM) with histopathologically confirmed diagnosis were enrolled. Pretreatment diffusion weighted imaging (DWI) was obtained in a 1.5T system using b values of 0, 500, and 1000 s/mm2. Whole lesion ADC volumes were analyzed using a histogram-based approach. Statistical analysis was performed using SPSS version 23. Results All investigated parameters were statistically different in comparison of both groups. Most importantly, ADCp10 was able to differentiate reliably between BA and GBM with excellent accuracy (0.948) using a cutpoint value of 70 × 10−5 mm2 × s−1. Conclusions ADC whole lesion histogram profiling provides a valuable tool to differentiate between morphologically indistinguishable mass lesions. Among the investigated parameters, the 10th percentile of the ADC volume distinguished best between GBM and BA. PMID:29719596

The value of whole lesion ADC histogram profiling to differentiate between morphologically indistinguishable ring enhancing lesions-comparison of glioblastomas and brain abscesses.

Science.gov (United States)

Horvath-Rizea, Diana; Surov, Alexey; Hoffmann, Karl-Titus; Garnov, Nikita; Vörkel, Cathrin; Kohlhof-Meinecke, Patricia; Ganslandt, Oliver; Bäzner, Hansjörg; Gihr, Georg Alexander; Kalman, Marcell; Henkes, Elina; Henkes, Hans; Schob, Stefan

2018-04-06

Morphologically similar appearing ring enhancing lesions in the brain parenchyma can be caused by a number of distinct pathologies, however, they consistently represent life-threatening conditions. The two most frequently encountered diseases manifesting as such are glioblastoma multiforme (GBM) and brain abscess (BA), each requiring disparate therapeutical approaches. As a result of their morphological resemblance, essential treatment might be significantly delayed or even ommited, in case results of conventional imaging remain inconclusive. Therefore, our study aimed to investigate, whether ADC histogram profiling reliably can distinguish between both entities, thus enhancing the differential diagnostic process and preventing treatment failure in this highly critical context. 103 patients (51 BA, 52 GBM) with histopathologically confirmed diagnosis were enrolled. Pretreatment diffusion weighted imaging (DWI) was obtained in a 1.5T system using b values of 0, 500, and 1000 s/mm 2 . Whole lesion ADC volumes were analyzed using a histogram-based approach. Statistical analysis was performed using SPSS version 23. All investigated parameters were statistically different in comparison of both groups. Most importantly, ADCp10 was able to differentiate reliably between BA and GBM with excellent accuracy (0.948) using a cutpoint value of 70 × 10 -5 mm 2 × s -1 . ADC whole lesion histogram profiling provides a valuable tool to differentiate between morphologically indistinguishable mass lesions. Among the investigated parameters, the 10th percentile of the ADC volume distinguished best between GBM and BA.

High-speed centrifugation induces aggregation of extracellular vesicles.

Science.gov (United States)

Linares, Romain; Tan, Sisareuth; Gounou, Céline; Arraud, Nicolas; Brisson, Alain R

2015-01-01

Plasma and other body fluids contain cell-derived extracellular vesicles (EVs), which participate in physiopathological processes and have potential biomedical applications. In order to isolate, concentrate and purify EVs, high-speed centrifugation is often used. We show here, using electron microscopy, receptor-specific gold labelling and flow cytometry, that high-speed centrifugation induces the formation of EV aggregates composed of a mixture of EVs of various phenotypes and morphologies. The presence of aggregates made of EVs of different phenotypes may lead to erroneous interpretation concerning the existence of EVs harbouring surface antigens from different cell origins.

High-speed centrifugation induces aggregation of extracellular vesicles

Directory of Open Access Journals (Sweden)

Romain Linares

2015-12-01

Full Text Available Plasma and other body fluids contain cell-derived extracellular vesicles (EVs, which participate in physiopathological processes and have potential biomedical applications. In order to isolate, concentrate and purify EVs, high-speed centrifugation is often used. We show here, using electron microscopy, receptor-specific gold labelling and flow cytometry, that high-speed centrifugation induces the formation of EV aggregates composed of a mixture of EVs of various phenotypes and morphologies. The presence of aggregates made of EVs of different phenotypes may lead to erroneous interpretation concerning the existence of EVs harbouring surface antigens from different cell origins.

Accuracy Assessment for the Three-Dimensional Coordinates by High-Speed Videogrammetric Measurement

Directory of Open Access Journals (Sweden)

Xianglei Liu

2018-01-01

Full Text Available High-speed CMOS camera is a new kind of transducer to make the videogrammetric measurement for monitoring the displacement of high-speed shaking table structure. The purpose of this paper is to validate the three-dimensional coordinate accuracy of the shaking table structure acquired from the presented high-speed videogrammetric measuring system. In the paper, all of the key intermediate links are discussed, including the high-speed CMOS videogrammetric measurement system, the layout of the control network, the elliptical target detection, and the accuracy validation of final 3D spatial results. Through the accuracy analysis, the submillimeter accuracy can be made for the final the three-dimensional spatial coordinates which certify that the proposed high-speed videogrammetric technique is a better alternative technique which can replace the traditional transducer technique for monitoring the dynamic response for the shaking table structure.

Motion-induced eddy current thermography for high-speed inspection

Directory of Open Access Journals (Sweden)

Jianbo Wu

2017-08-01

Full Text Available This letter proposes a novel motion-induced eddy current based thermography (MIECT for high-speed inspection. In contrast to conventional eddy current thermography (ECT based on a time-varying magnetic field created by an AC coil, the motion-induced eddy current is induced by the relative motion between magnetic field and inspected objects. A rotating magnetic field created by three-phase windings is used to investigate the heating principle and feasibility of the proposed method. Firstly, based on Faraday’s law the distribution of MIEC is investigated, which is then validated by numerical simulation. Further, experimental studies are conducted to validate the proposed method by creating rotating magnetic fields at different speeds from 600 rpm to 6000 rpm, and it is verified that rotating speed will increase MIEC intensity and thereafter improve the heating efficiency. The conclusion can be preliminarily drawn that the proposed MIECT is a platform suitable for high-speed inspection.

Technical report of electronics shop characteristics of high speed electronics component, (1)

International Nuclear Information System (INIS)

Watanabe, Shin-ichi; Shiino, Kazuo.

1975-01-01

We must develop electronics circuits for high speed signals. The electronics components of the circuits make use of the special components. This report treats a pulse response of the electronics components (i.e. coaxial cable, connector, resistor, capacitor, diode, transistor) for high speed electronics. The results of this report was already applied constructions of high speed electronics circuits and experimental equipments of the High Energy Physics Division. (auth.)

High-Speed RaPToRS

Science.gov (United States)

Henchen, Robert; Esham, Benjamin; Becker, William; Pogozelski, Edward; Padalino, Stephen; Sangster, Thomas; Glebov, Vladimir

2008-11-01

The High-Speed Rapid Pneumatic Transport of Radioactive Samples (HS-RaPToRS) system, designed to quickly and safely move radioactive materials, was assembled and tested at the Mercury facility of the Naval Research Laboratory (NRL) in Washington D.C. A sample, which is placed inside a four-inch-diameter carrier, is activated before being transported through a PVC tube via airflow. The carrier travels from the reaction chamber to the end station where it pneumatically brakes prior to the gate. A magnetic latch releases the gate when the carrier arrives and comes to rest. The airflow, optical carrier-monitoring devices, and end gate are controlled manually or automatically with LabView software. The installation and testing of the RaPToRS system at NRL was successfully completed with transport times of less than 3 seconds. The speed of the carrier averaged 16 m/s. Prospective facilities for similar systems include the Laboratory for Laser Energetics and the National Ignition Facility.

A Low Power Rad-Hard ADC for the KID Readout Electronics, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The proposal aims to develop a radiation hardened analog-to-digital converter (ADC) required for the Kinetic Inductance Detector (KID) readout electronics. KIDs are...

Effect of welding current and speed on occurrence of humping bead in high-speed GMAW

Institute of Scientific and Technical Information of China (English)

Chen Ji; Wu Chuansong

2009-01-01

The developed mathematical model of humping formation mechanism in high-speed gas metal arc welding (GMAW) is used to analyze the effects of welding current and welding speed on the occurrence of humping bead. It considers both the momentum and heat content of backward flowing molten jet inside weld pool. Three-dimensional geometry of weld pool, the spacing between two adjacent humps and hump height along humping weld bead are calculated under different levels of welding current and welding speed. It shows that wire feeding rate, power intensity and the moment of backward flowing molten jet are the major factors on humping bead formation.

Comparative study of the sensitivity of ADC value and T{sub 2} relaxation time for early detection of Wallerian degeneration

Energy Technology Data Exchange (ETDEWEB)

Zhang Fan [Department of Radiology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing 210002 (China); Lu Guangming, E-mail: cjr.luguangming@vip.163.com [Department of Radiology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing 210002 (China); Zee Chishing, E-mail: chishing@usc.edu [Department of Radiology, USC Keck School of Medicine (United States)

2011-07-15

Background and purpose: Wallerian degeneration (WD), the secondary degeneration of axons from cortical and subcortical injuries, is associated with poor neurological outcome. There is some quantitative MR imaging techniques used to estimate the biologic changes secondary to delayed neuronal and axonal losses. Our purpose is to assess the sensitivity of ADC value and T{sub 2} relaxation time for early detection of WD. Methods: Ten male Sprague-Dawley rats were used to establish in vivo Wallerian degeneration model of CNS by ipsilateral motor-sensory cortex ablation. 5 days after cortex ablation, multiecho-T{sub 2} relaxometry and multi-b value DWI were acquired by using a 7 T MR imaging scanner. ADC-map and T{sub 2}-map were reconstructed by post-processing. ROIs are selected according to pathway of corticospinal tract from cortex, internal capsule, cerebral peduncle, pons, medulla oblongata to upper cervical spinal cord to measure ADC value and T{sub 2} relaxation time of healthy side and affected side. The results were compared between the side with cortical ablation and the side without ablation. Results: Excluding ablated cortex, ADC values of the corticospinal tract were significantly increased (P < 0.05) in affected side compared to the unaffected, healthy side; no difference in T{sub 2} relaxation time was observed between the affected and healthy sides. Imaging findings were correlated with histological examinations. Conclusion: As shown in this animal experiment, ADC values could non-invasively demonstrate the secondary degeneration involving descending white matter tracts. ADC values are more sensitive indicators for detection of early WD than T{sub 2} relaxation time.

Wavelet-OFDM Signal Transmission Characteristics with High-Speed PLC Modem

Science.gov (United States)

Nakagawa, Kenichi; Tokuda, Masamitsu; Igata, Yuji

In this paper, we measured the interference immunity characteristics of high-speed PLC system using Wavelet-OFDM when the narrowband conducted interference wave signal was injected. As the results, it was clear that (1) measured PHY rate at the all frequency band hardly decreased in C/I (Carrier to Interference ratio) of above 20dB, but began to decrease rapidly in C/I of below 0dB when the interference signal was injected in the frequency band of high-speed PLC signal, (2) when C/I became from 0dB to -20dB, the measured PHY rate at the frequency existing the notch band were improved around 10Mbps than that at the frequency not existing the notch band, (3) when the narrowband interference wave was injected outside of frequency band of high-speed PLC signal, the measured PHY rate did not decrease than that in each notch band. Therefore, it was revealed that high-speed PLC system using Wavelet-OFDM had good interference immunity characteristics.

High-speed high-sensitivity infrared spectroscopy using mid-infrared swept lasers (Conference Presentation)

Science.gov (United States)

Childs, David T. D.; Groom, Kristian M.; Hogg, Richard A.; Revin, Dmitry G.; Cockburn, John W.; Rehman, Ihtesham U.; Matcher, Stephen J.

2016-03-01

Infrared spectroscopy is a highly attractive read-out technology for compositional analysis of biomedical specimens because of its unique combination of high molecular sensitivity without the need for exogenous labels. Traditional techniques such as FTIR and Raman have suffered from comparatively low speed and sensitivity however recent innovations are challenging this situation. Direct mid-IR spectroscopy is being speeded up by innovations such as MEMS-based FTIR instruments with very high mirror speeds and supercontinuum sources producing very high sample irradiation levels. Here we explore another possible method - external cavity quantum cascade lasers (EC-QCL's) with high cavity tuning speeds (mid-IR swept lasers). Swept lasers have been heavily developed in the near-infrared where they are used for non-destructive low-coherence imaging (OCT). We adapt these concepts in two ways. Firstly by combining mid-IR quantum cascade gain chips with external cavity designs adapted from OCT we achieve spectral acquisition rates approaching 1 kHz and demonstrate potential to reach 100 kHz. Secondly we show that mid-IR swept lasers share a fundamental sensitivity advantage with near-IR OCT swept lasers. This makes them potentially able to achieve the same spectral SNR as an FTIR instrument in a time x N shorter (N being the number of spectral points) under otherwise matched conditions. This effect is demonstrated using measurements of a PDMS sample. The combination of potentially very high spectral acquisition rates, fundamental SNR advantage and the use of low-cost detector systems could make mid-IR swept lasers a powerful technology for high-throughput biomedical spectroscopy.

Polymer Surface Textured with Nanowire Bundles to Repel High-Speed Water Drops.

Science.gov (United States)

Li, Y P; Li, X Y; Zhu, X P; Lei, M K; Lakhtakia, A

2018-05-11

Water drops impacting windshields of high-speed trains and aircraft as well as blades in steam turbine power generators obliquely and at high speeds are difficult to repel. Impacting drops penetrate the void regions of nanotextured and microtextured superhydrophobic coatings, with this pinning resulting in the loss of drop mobility. In order to repel high-speed water drops, we nanotextured polymer surfaces with nanowire bundles separated from their neighbors by microscale void regions, with the nanowires in a bundle separated from their neighbors by nanoscale void regions. Water drops with speeds below a critical speed rebound completely. Water drops with speeds exceeding a critical speed rebound partially, but residual droplets that begin to be pinned undergo a spontaneous dewetting process and slide off. The natural oscillations of residual droplets drive this dewetting process in the interbundle void regions, resulting in a transition from the sticky Wenzel state to the slippery Cassie state without external stimuli.

Impact of Increased Football Field Width on Player High-Speed Collision Rate.

Science.gov (United States)

Joseph, Jacob R; Khalsa, Siri S; Smith, Brandon W; Park, Paul

2017-07-01

High-acceleration head impact is a known risk for mild traumatic brain injury (mTBI) based on studies using helmet accelerometry. In football, offensive and defensive players are at higher risk of mTBI due to increased speed of play. Other collision sport studies suggest that increased playing surface size may contribute to reductions in high-speed collisions. We hypothesized that wider football fields lead to a decreased rate of high-speed collisions. Computer football game simulation was developed using MATLAB. Four wide receivers were matched against 7 defensive players. Each offensive player was randomized to one of 5 typical routes on each play. The ball was thrown 3 seconds into play; ball flight time was 2 seconds. Defensive players were delayed 0.5 second before reacting to ball release. A high-speed collision was defined as the receiver converging with a defensive player within 0.5 second of catching the ball. The simulation counted high-speed collisions for 1 team/season (65 plays/game for 16 games/season = 1040 plays/season) averaged during 10 seasons, and was validated against existing data using standard field width (53.3 yards). Field width was increased in 1-yard intervals up to 58.3 yards. Using standard field width, 188 ± 4 high-speed collisions were seen per team per season (18% of plays). When field width increased by 3 yards, high-speed collision rate decreased to 135 ± 3 per team per season (28% decrease; P football field width can lead to substantial decline in high-speed collisions, with potential for reducing instances of mTBI in football players. Copyright © 2017 Elsevier Inc. All rights reserved.

Application of Σ-ΔADC in fluorescence measurement

International Nuclear Information System (INIS)

Hao Yan; Chen Ziyu; Shen Ji

2011-01-01

It introduces the measurement system of fluorescence intensity, the Σ-ΔADC used as its core components. The system consisted of ADS1255, microcontrollers LPC2368 devices, etc. LPC2368 is used as the control, data process and communication interface. Diagram of the system is given. The linear response experiments, frequency response experiments, measurement accuracy experiments and long-time stability experiments were carried out. Experiments show that the system reaches a good linear response, and the measurement accuracy reaches up to 0.01%. (authors)

High-speed and supersonic upward plasma drifts: multi-instrumental study

Science.gov (United States)

Astafyeva, E.; Zakharenkova, I.; Hairston, M. R.; Huba, J.; Coley, W. R.

2017-12-01

Since the pioneering observations by Aggson et al. (1992, JGR, doi: 10.1002/92JA00644), there have been several reports of the occurrence of high-speed (Vz>800 m/s) and supersonic plasma flows in the post-sunset (e.g., Hysell et al., 1994, JGR, doi: 10.1029/94JA00476; Hanson et al., 1997, JGR, doi: 10.1029/96JA03376) and the pre-dawn sector (Astafyeva and Zakharenkova, 2015, GRL, doi:10.1002/2015GL066369). However, despite this observational evidence, these events remain rare and are not well understood. The main issue is to determine the background conditions leading to the occurrence of these high-speed plasma drifts. In this work, we perform a multi-instrumental study of high-speed and supersonic upward plasma drift events/structures. For this purpose, we analyze data from several ground-based and space-borne instruments, including data from the DMSP, Swarm and C/NOFS (IVM instrument) satellites. In addition to the space-borne instruments, we use data from ground-based GPS-receivers and ionosondes to further investigate the background ionosphere conditions, as well as the effects produced by the plasma bubbles and ionospheric irregularities. Besides the observations, we add the SAMI3/ESF modeling results on plasma bubble simulations and high-speed drifts inside plasma bubbles. TIE-GCM runs (from the CCMC, https://ccmc.gsfc.nasa.gov) are used to define the background atmospheric/ionospheric and electrodynamical conditions leading to the occurrence of the high-speed and supersonic plasma drift events. Our search of events with upward plasma drift exceeding 800 m/s in the data of DMSP for the years 2002-2016 shows that such high-speed events are extremely rare. During this period of time, only 6 events were found, two of them occurred during the recovery phase of a geomagnetic storm, while the other four were detected during geomagnetically quiet conditions. Concerning the generation of such events, our preliminary results show that enhanced electric fields are

Comparison of high-speed transportation systems in special consideration of investment costs

Directory of Open Access Journals (Sweden)

R. Schach

2007-10-01

Full Text Available In this paper a substantial comparison of different high-speed transportation systems and an approach to stochastic cost estimations are provided. Starting from the developments in Europe, the high-speed traffic technical characteristics of high-speed railways and Maglev systems are compared. But for a comprehensive comparison more criterions must be included and led to a wider consideration and the development of a multi-criteria comparison of high-speed transportation systems. In the second part a stochastic approach to cost estimations of infrastructure projects is encouraged. Its advantages in comparison with the traditional proceeding are presented and exemplify the practical implementation.

Incorporating YBCO Coated Conductors in High-speed Superconducting Generators

Science.gov (United States)

2008-07-01

4.0 kW/lb (8.82 kW/kg). The machine configuration chosen by GE for design was a homopolar inductor alternator (HIA) which locates the...extremely severe ac loss environment. Even if this is ultimately impossible for high speed generators, it may not preclude lower speed motors and

Social exclusion and high speed rail: The case study of Spain

Energy Technology Data Exchange (ETDEWEB)

Pagliara, F.; Menicocci, F.; Vassallo, J.M.; Gomez, J.

2016-07-01

Very few contributions in the literature have dealt with the issue of social exclusion related to High Speed Rail systems. The objective of this manuscript is to understand what are the factors excluding users from choosing High Speed Rail services considering as case study Spain. For this purpose, a Revealed Preference survey was employed in November and December 2015. A questionnaire was submitted to users of the Spanish transport systems travelling for long distance-journeys. The aim was that of investigating their perception of High Speed Rail system and the factors inhibiting passengers or excluding them from its use. Data about their socioeconomic characteristics were collected as well. The main result of the survey has been that a relationship between social exclusion and High Speed Rail in Spain is present, especially in terms of geographical exclusion. (Author)

Fast Imaging Detector Readout Circuits with In-Pixel ADCs for Fourier Transform Imaging Spectrometers

Science.gov (United States)

Rider, D.; Blavier, J-F.; Cunningham, T.; Hancock, B.; Key, R.; Pannell, Z.; Sander, S.; Seshadri, S.; Sun, C.; Wrigley, C.

2011-01-01

Focal plane arrays (FPAs) with high frame rates and many pixels benefit several upcoming Earth science missions including GEO-CAPE, GACM, and ACE by enabling broader spatial coverage and higher spectral resolution. FPAs for the PanFTS, a high spatial resolution Fourier transform spectrometer and a candidate instrument for the GEO-CAPE mission are the focus of the developments reported here, but this FPA technology has the potential to enable a variety of future measurements and instruments. The ESTO ACT Program funded the developed of a fast readout integrated circuit (ROIC) based on an innovative in-pixel analog-to-digital converter (ADC). The 128 X 128 pixel ROIC features 60 ?m pixels, a 14-bit ADC in each pixel and operates at a continuous frame rate of 14 kHz consuming only 1.1 W of power. The ROIC outputs digitized data completely eliminating the bulky, power consuming signal chains needed by conventional FPAs. The 128 X 128 pixel ROIC has been fabricated in CMOS and tested at the Jet Propulsion Laboratory. The current version is designed to be hybridized with PIN photodiode arrays via indium bump bonding for light detection in the visible and ultraviolet spectral regions. However, the ROIC design incorporates a small photodiode in each cell to permit detailed characterization of the ROICperformance without the need for hybridization. We will describe the essential features of the ROIC design and present results of ROIC performance measurements.

On-Line Path Generation and Tracking for High-Speed Wheeled Autonomous Vehicles

Science.gov (United States)

2006-02-17

On-Line Path Generation and Tracking for High-Speed Wheeled Autonomous Vehicles Report Title ABSTRACT In this work we proposed two semi-analytic...298-102 Enclosure 1 On-Line Path Generation and Tracking for High-Speed Wheeled Autonomous Vehicles by...Specifically, the following problems will be addressed during this project: 2.1 Challenges The problem of trajectory planning for high-speed autonomous vehicles is

Copper infiltrated high speed steels based composites

International Nuclear Information System (INIS)

Madej, M.; Lezanski, J.

2003-01-01

High hardness, mechanical strength, heat resistance and wear resistance of M3/2 high speed steel (HSS) make it an attractive material. Since technological and economical considerations are equally important, infiltration of high-speed steel skeleton with liquid cooper has proved to be a suitable technique whereby fully dense material is produced at low cost. Attempts have been made to describe the influence of the production process parameters and alloying additives, such as tungsten carbide on the microstructure and mechanical properties of copper infiltrated HSS based composites. The compositions of powder mixtures are 100% M3/2, M3/2+10% Wc, M3/2=30% WC. The powders were uniaxially cold compacted in a cylindrical die at 800 MPa. The green compacts were sintered in vacuum at 1150 o C for 60 minutes. Thereby obtained porous skeletons were subsequently infiltrated with cooper, by gravity method, in vacuum furnace at 1150 o C for 15 minutes. (author)

Some important aspects of the amplitude, charge and shape analog signals digitization in nuclear physics experiment

International Nuclear Information System (INIS)

Kulka, Z.

1995-01-01

One of the fundamental reasons of the special requirements concerning analog-to-digital converters (ADC's) used in nuclear experimental physics, especially in nuclear spectroscopy, in comparison to the conventional ADC's is a fact that they are utilized for continuous distribution measurements which are the nuclear radiation spectra. The ADC's used for distribution registration in form of amplitude or charge histogram spectra should have the differential linearity of two orders of magnitude better than that for conventional ADC's. Moreover, the problem of achievement the acceptable differential linearity (as well as stability) in nuclear spectroscopy is much more complicated because high resolution and high speed of the converters are also required. The first requirement comes out from application of semiconductor detectors, the second one comes from the statistical character of the nuclear processes, as well as, a necessity of collection of huge amount of nuclear data - often in a short time. In this report the influence of the specific needs of the nuclear experiments on the conversion methods selection and construction principles of the pulse ADC's is analyzed. Focus is taken on these ADC's which are used mainly to digital amplitude and charge detector signals measurements in nuclear spectroscopy. Based on the chosen examples of different types of ADC's it is shown how to obtain the required metrological parameters by using enlarged converter's structures and proper choice of the electronics components. In addition, a problem of the detector signals shape measurements in particle physics using the high speed flash ADC's is also discussed. (author). 196 refs, 99 figs, 7 tabs

Comparison of ADC map with trace map in the normal and infarct areas of the brains of stroke patients

International Nuclear Information System (INIS)

Kim, Seung Hyung; Yoon, Pyeong Ho; Jeong, Eun Kee; Oh, Young Taick; Kim, Dong Ik

1999-01-01

To compare ADC mapping with trace mapping in normal and infarct areas of the brains of stroke patients. Eighteen patients diagnosed on the basis of clinical and brain MRI examinations as suffering from brain infarction were included in this study (hyperacute-1, acute-4, subacute-12, chronic-1). Diffusion weighted images of three orthogonal directions of a patient's brain were obtained by means of a single shot EPI pulse sequence, using a diffusion gradient with four serial b-factors. Three ADC maps were then reconstructed by post-image processing and were summed pixel by pixel to yield a trace map. ROIs were selected in the normal areas of white matter, gray matter and CSF of one hemisphere, and other ROIs of the same size were selected at the same site of the contralateral hemisphere. ADC and trace values were measured and right/left ratios of ADC and trace values were calculated. Using these values, we then compared the ADC map with the trace map, and compared the degree of anisotropic diffusion between white matter, gray matter and CSF. Except for three, whose infarct lesions were small and lay over white and gray matter, patients were divided into two groups. Those with infarct in the white matter (n=10) were assigned to one group, and those with infarct in the gray matter (n=5) to the other. ROIs were selected in the infarct area and other ROIs of the same size were selected at the same site of the contralateral hemisphere. ADC and trace values were measured and infarct/contralateral ratios were calculated. We then compared ADC ratio with trace ratio in white matter and gray matter infarct. In normal white matter, the Dxx ratio was 0.980±0.098, the Dyy ratio 1.019±0.086, the Dzz ratio 0.999±0.111, and the trace ratio 0.995±0.031. In normal gray matter, the Dxx ratio was 1.001±0.058, the Dyy ratio 0.996±0.063, Dzz ratio 1.005±0.070, and the trace ratio 1.001±0.028. In CSF, the Dxx ratio was 1.002±0.064, the Dyy ratio 1.023±0.055, the Dzz ratio 0.999�

The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer.

Science.gov (United States)

Sokmen, Bedriye Koyuncu; Sokmen, Dogukan; Ucar, Nese; Ozkurt, Huseyin; Simsek, Abdulmuttalip

2017-12-31

Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study. Risk classification of patients were evaluated as low-risk (Group 1) (n = 20) (Stage T1c-T2a, PSA T3a, PSA > 20 ng/ml, Gleason Score > 7). Diffusion-weighted MR images, dynamic contrasted MR images, and ADC values of the prostates were correlated. ADC values of the cases in Group 3 were lower than those of the other groups (p values of the areas without malignancy did not differ significantly between groups (p > 0.05). Biological activity of the tumor tissue was determined by GS, while a negative correlation was observed between GSs and ADC values of the patients, (p values were obtained. These measured values can play a role in the noninvasive determination of the cellularity of the tumoral mass.

Design of a low power 10 bit 300 ksps multi-channel SAR ADC for wireless sensor network applications

International Nuclear Information System (INIS)

Hong Hui; Li Shiliang; Zhou Tao

2015-01-01

This paper presents a low power 10 bit 300 ksps successive approximation register analog-to-digital converter (SAR ADC) which is applied in wireless sensor network (WSN) applications. A single ended energy-saving split capacitor DAC array and a latch comparator with a rail to rail input stage are utilized to implement the ADC, which can reduce power dissipation while expanding the full scale input range and improve the signal-to-noise ratio (SNR). For power optimization the supply voltage of the SAR ADC is designed to be as low as 2 V. Four analog input channels are designed which make the ADC more suitable for WSN applications. The prototype circuit is fabricated using 3.3 V, 0.35 μm 2P4M CMOS technology and occupies an active chip area of 1.23 mm 2 . The test results show that the power dissipation is only 200 μW at a 2 V power supply and a sampling rate of 166 ksps. The calculated SNR is 58.25 dB, the ENOB is 9.38 bit and the FOM is 4.95 pJ/conversion-step. (paper)

Novel high speed fiber-optic pressure sensor systems.

Science.gov (United States)

2014-03-01

The goal of this project is to develop a complete test of this technology for high-speed, high-accuracy applications, specifically cost-effective data acquisition techniques and practical mounting methods tailored for the subject environment. The sec...

Energetic optimization of regenerative braking for high speed railway systems

International Nuclear Information System (INIS)

Frilli, Amedeo; Meli, Enrico; Nocciolini, Daniele; Pugi, Luca; Rindi, Andrea

2016-01-01

Highlights: • A model of longitudinal dynamics of the High-speed train ETR1000 is presented. • The model includes on board traction and braking subsystems. • Interactions between overhead line and power line are modelled. • The model is validated on real experimental data. • An energy storage strategy for a high-speed line is proposed. - Abstract: The current development trend in the railway field has led to an ever increasing interest for the energetic optimization of railway systems (especially considering the braking phases), with a strong attention to the mutual interactions between the loads represented by railway vehicles and the electrical infrastructure, including all the sub-systems related to distribution and smart energy management such as energy storage systems. In this research work, the authors developed an innovative coupled modelling approach suitable for the analysis of the energetic optimization of railway systems and based on the use of the new object oriented language Matlab-Simscape™, which presents several advantages with respect to conventional modelling tools. The proposed model has been validated considering an Italian Direct Current High-speed line and the High-speed train ETR 1000. Furthermore, the model has been used to perform an efficiency analysis, considering the use of energy storage devices. The results obtained with the developed model show that the use of energy recovery systems in high-speed railway can provide great opportunities of energy savings.

Tooling device design for vibration-assisted high speed shaping of PMMA

International Nuclear Information System (INIS)

Mostofa, Md. Golam; Noh, J. H.; Kim, H. Y.; Ahn, J. H.; Kang, D. B.

2010-01-01

PMMA optical components that are used as one of the most important parts of high precision equipment and machines are increasingly replacing the glass due to the various advantages of PMMA. Especially in Light Guide Panels, the PMMA sheet that is used in Liquid Crystal Displays plays an important role in scattering the incident light and requires very fine machining as the sheet is directly related to the optical characteristics of the panels. The High Speed End milling and High Speed Shaping processes that are widely adopted and applied to the precise machining of Light Incident Plane still have quality problems, such as cracks, breakages, poor waviness, and straightness. This paper presents the tooling device design for machining a Light Incident Plane through vibration-assisted High Speed Shaping for increasing the optical quality by minimizing the above-mentioned problems. The cutting tool and the tool post presented in this paper are designed by the authors to increase the magnitude of the cutting stroke by adopting the resonant frequency without weakening the stiffness and to reduce vibrations during even high speed feeding. The dynamic characteristics of the cutting tool and the tool post are evaluated through simulation and experiment as well. The results reveal very appropriate dynamic characteristics for vibration-assisted High Speed Shaping

A novel portable multi-channel analyzer based on high-speed microcontroller

International Nuclear Information System (INIS)

Lou Xinghua; Yi Hongchang; Wang Yuemin

2005-01-01

This paper introduces a novel portable multi-channel analyzer (MCA) based on high-speed microcontroller. The hardware implementation and the software scenario of the MCA are discussed. The MCA has features of high speed, small size and better performances. (authors)

Yonjung High-Speed Railway Bridge Assessment Using Output-Only Structural Health Monitoring Measurements under Train Speed Changing

Directory of Open Access Journals (Sweden)

Mosbeh R. Kaloop

2016-01-01

Full Text Available Yonjung Bridge is a hybrid multispan bridge that is designed to transport high-speed trains (HEMU-430X with maximum operating speed of 430 km/h. The bridge consists of simply supported prestressed concrete (PSC and composite steel girders to carry double railway tracks. The structural health monitoring system (SHM is designed and installed to investigate and assess the performance of the bridge in terms of acceleration and deformation measurements under different speeds of the passing train. The SHM measurements are investigated in both time and frequency domains; in addition, several identification models are examined to assess the performance of the bridge. The drawn conclusions show that the maximum deflection and acceleration of the bridge are within the design limits that are specified by the Korean and European codes. The parameters evaluation of the model identification depicts the quasistatic and dynamic deformations of PSC and steel girders to be different and less correlated when higher speeds of the passing trains are considered. Finally, the variation of the frequency content of the dynamic deformations of the girders is negligible when high speeds are considered.

Charge-sharing SAR ADCs for low-voltage low-power applications

CERN Document Server

Rabuske, Taimur

2017-01-01

This book introduces readers to the potential of charge-sharing (CS) successive approximation register (SAR) analog-to-digital converters (ADCs), while providing extensive analysis of the factors that limit the performance of the CS topology. The authors present guidelines and useful techniques for mitigating the limitations of the architecture, while focusing on the implementation under restricted power budgets and voltage supplies.

High Speed Trimaran (HST) Seatrain Experiments, Model 5714

Science.gov (United States)

2013-12-01

wave absorbing beach at the other. The carriage has electro-hydraulic drive and a regenerative braking system with a maximum carriage speed of 20...Carderock Division To: Commander, Naval Sea Systems Command (PMS3 85) Subj FORWARDING OF REPORT Encl: (1) NSWCCD-80-TR-2013/015, "High Speed Trimaran...and verify the system processes and capability. Your comments will be reviewed and are appreciated. JUDE F. BROWN By direction Copy to: NAVSEA

High speed motion neutron radiography of dynamic events

International Nuclear Information System (INIS)

Robinson, A.H.; Barton, J.P.

1983-01-01

The development of a technique that permits neutron radiographic analysis of dynamic processes over a period lasting from one to ten milliseconds is described. The key to the technique is the use of a neutron pulse broad enough to span the duration of a brief event and intense enough to allow recording of the results on a high-speed movie film at frame rates of 10,000 frames/sec. Some typical application results in ballistic studies and two-phase flow are shown and discussed. The use of scintillator screens in the high-speed motion neutron radiography system is summarized and the statistical limitations of the technique are discussed

Chemical and biological studies of Lobelia flaccida (C. Presl) A.DC ...

African Journals Online (AJOL)

Chemical and biological studies of Lobelia flaccida (C. Presl) A.DC leaf: a medicinal plant used by traditional healers in Eastern Cape, South Africa. ... (85 mg/kg, intraperitoneally)-induced convulsion model in mice, normal saline and diazepam (1 mg/kg, i.p.) served as negative and positive control groups respectively.

Experimental High Speed Milling of the Selected Thin-Walled Component

Directory of Open Access Journals (Sweden)

Jozef Zajac

2017-11-01

Full Text Available In a technical practice, it is possible to meet thin-walled parts more and more often. These parts are most commonly used in the automotive industry or aircraft industry to reduce the weight of different design part of cars or aircraft. Presented article is focused on experimental high speed milling of selected thin-walled component. The introduction of this article presents description of high speed machining and specification of thin – walled parts. The experiments were carried out using a CNC machine Pinnacle VMC 650S and C45 material - plain carbon steel for automotive components and mechanical engineering. In the last part of the article, described are the arrangements to reduction of deformation of thin-walled component during the experimental high speed milling.

Cadence® High-Speed PCB Layout Flow Workshop

CERN Document Server

2003-01-01

Last release of Cadence High-Speed PCB Design methodology (PE142) based on Concept-HDL schematic editor, Constraint Manager, SPECCTRAQuest signal integrity analysis tool and ALLEGRO layout associated with SPECCTRA auto router tools, is now enough developed and stable to be taken into account for high-speed board designs at CERN. The implementation of this methodology, build around the new Constraint Manager program, is essential when you have to develop a board having a lot of high-speed design rules such as terminated lines, large bus structures, maximum length, timing, crosstalk etc.. that could not be under control by traditional method. On more conventional designs, formal aspect of the methodology could avoid misunderstanding between hardware and ALLEGRO layout designers, minimizing prototype iteration, development time and price. The capability to keep trace of the original digital designer intents in schematic or board layout, loading formal constraints in EDMS, could also be considered for LHC electro...

High-speed photography of dynamic photoelastic experiment with a highly accurate blasting machine

Science.gov (United States)

Katsuyama, Kunihisa; Ogata, Yuji; Wada, Yuji; Hashizume, K.

1995-05-01

A high accurate blasting machine which could control 1 microsecond(s) was developed. At first, explosion of a bridge wire in an electric detonator was observed and next the detonations of caps were observed with a high speed camera. It is well known that a compressed stress wave reflects at the free face, it propagates to the backward as a tensile stress wave, and cracks grow when the tensile stress becomes the dynamic tensile strength. The behavior of these cracks has been discussed through the observation of the dynamic photoelastic high speed photography and the three dimensional dynamic stress analysis.

Compensator design for improved counterbalancing in high speed atomic force microscopy

OpenAIRE

Bozchalooi, I. S.; Youcef-Toumi, K.; Burns, D. J.; Fantner, G. E.

2011-01-01

High speed atomic force microscopy can provide the possibility of many new scientific observations and applications ranging from nano-manufacturing to the study of biological processes. However, the limited imaging speed has been an imperative drawback of the atomic force microscopes. One of the main reasons behind this limitation is the excitation of the AFM dynamics at high scan speeds, severely undermining the reliability of the acquired images. In this research, we propose a piezo based, ...

A main amplifier circuit and data acquisition system for charged particle detector array

International Nuclear Information System (INIS)

Hao Rui; Ge Yucheng

2011-01-01

The charged particle detector array has huge amounts of signal and needs high counting rate. To meet the requirements, a main amplifier and analog-to-digital conversion circuit based on high-speed op-amp chips and ADC chip was designed. A 51-MCU was used to control the circuit of ADC and the USB communication chip. The signals were digitized and uploaded by the MCU-ADC-USB circuit. The whole system has a compact hardware structure and a reasonable controlling software, which meet the design requirements. (authors)

An offset cancellation technique in a switched-capacitor comparator for SAR ADCs

International Nuclear Information System (INIS)

Tong Xingyuan; Zhu Zhangming; Yang Yintang

2012-01-01

An offset cancellation technique for a SAR (successive approximation register) ADC switched-capacitor comparator is described. The comparator is designed with a pre-amplifying and regenerative latching structure and realized in 0.18 μm CMOS. With the first stage preamplifier offset cancellation and low offset regenerative latching approach, the equivalent offset of the comparator is reduced to < 0.55 mV. By using the pre-amplifying and regenerative latching comparison mode the comparator exhibits low power dissipation. Under a 1.8 V power supply, with a 200 kS/s ADC sampling rate and 3 MHz clock frequency, a 13-bit comparison resolution is reached and less than 0.09 mW power dissipation is consumed. The superiority of this comparator is discussed and proved by the post-simulation and application to a 10 bit 200 kS/s touch screen SAR A/D converter. (semiconductor integrated circuits)

High-speed cinematography of gas-tungsten arc welding: theory and application

Energy Technology Data Exchange (ETDEWEB)

Reynolds, L.D.; Key, J.F.

1981-06-01

High-speed photo-instrumentation theory and application are reviewed, with particular emphasis on high-speed cinematography, for the engineer who has not acquired an extensive background in scientific photography. Camera systems, optics, timing system, lighting, photometric equipment, filters, and camera mounts are covered. Manufacturers and other resource material are listed in the Appendices. The properties and processing of photosensitive materials suitable for high-speed photography are reviewed, and selected film data are presented. Methods are described for both qualitative and quantitative film analysis. This technology is applied to the problem of analyzing plasma dynamics in a gas-tungsten welding arc.

Design of high-speed ECT and ERT system

International Nuclear Information System (INIS)

Wang Baoliang; Huang Zhiyao; Li Haiqing

2009-01-01

Process tomography technique provides a novel method to investigate the multi-phase flow distribution inside pipe or vessel. Electrical resistance tomography (ERT) and electrical capacitance tomography (ECT) are extensively studied in recent years. As the capacitance to voltage and resistance to voltage converters run faster, the speeds of other circuits in the system, such as MCU, A/D, D/A etc, have become the bottlenecks of improving the speed. This paper describes a new dual-modal, ECT and ERT, data acquisition system. The system is controlled by a digital signal processor. Both the ERT and the ECT systems use one platform to simplify the system design and maintenance. The system can work at high speed which is only limited by the capacitance to voltage converter or resistance to voltage converter. Primary test results show the speed of the new system is 1400 frames/second for 16-electrode ERT and 2200 frames/second for 12-electrode ECT.

Gearbox Reliability Collaborative Investigation of Gearbox Motion and High-Speed-Shaft Loads

Energy Technology Data Exchange (ETDEWEB)

Keller, Jon [National Renewable Energy Lab. (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sethuraman, Latha [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-03-18

This paper extends a model-to-test validation effort to examine the effect of different constant rotor torque and moment conditions and intentional generator misalignment on the gearbox motion and high-speed-shaft loads. Fully validating gearbox motion and high-speed-shaft loads across a range of test conditions is a critical precursor to examining the bearing loads, as the gearbox motion and high-speed-shaft loads are the drivers of these bearing loads.

High-speed railways in Japan

International Nuclear Information System (INIS)

Kyotani, Y.

1974-01-01

This paper reviews the development of conventional railways in Japan, leading up to the Shinkansen line, which at present runs at speeds up to 210km/h, and will in the future be speeded up to 260km/h. It then goes on to review the development of a superconductive, magnetically levitated train, which will constitute the next generation of railways, running at speeds of up to 500km/h. (author)

Double Tunneling Injection Quantum Dot Lasers for High Speed Operation

Science.gov (United States)

2017-10-23

Double Tunneling-Injection Quantum Dot Lasers for High -Speed Operation The views, opinions and/or findings contained in this report are those of...SECURITY CLASSIFICATION OF: 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND SUBTITLE 13. SUPPLEMENTARY NOTES 12. DISTRIBUTION AVAILIBILITY STATEMENT 6...State University Title: Double Tunneling-Injection Quantum Dot Lasers for High -Speed Operation Report Term: 0-Other Email: asryan@vt.edu Distribution

In situ flash x-ray high-speed computed tomography for the quantitative analysis of highly dynamic processes

Science.gov (United States)

Moser, Stefan; Nau, Siegfried; Salk, Manfred; Thoma, Klaus

2014-02-01

The in situ investigation of dynamic events, ranging from car crash to ballistics, often is key to the understanding of dynamic material behavior. In many cases the important processes and interactions happen on the scale of milli- to microseconds at speeds of 1000 m s-1 or more. Often, 3D information is necessary to fully capture and analyze all relevant effects. High-speed 3D-visualization techniques are thus required for the in situ analysis. 3D-capable optical high-speed methods often are impaired by luminous effects and dust, while flash x-ray based methods usually deliver only 2D data. In this paper, a novel 3D-capable flash x-ray based method, in situ flash x-ray high-speed computed tomography is presented. The method is capable of producing 3D reconstructions of high-speed processes based on an undersampled dataset consisting of only a few (typically 3 to 6) x-ray projections. The major challenges are identified, discussed and the chosen solution outlined. The application is illustrated with an exemplary application of a 1000 m s-1 high-speed impact event on the scale of microseconds. A quantitative analysis of the in situ measurement of the material fragments with a 3D reconstruction with 1 mm voxel size is presented and the results are discussed. The results show that the HSCT method allows gaining valuable visual and quantitative mechanical information for the understanding and interpretation of high-speed events.

Influences of Cutting Speed and Material Mechanical Properties on Chip Deformation and Fracture during High-Speed Cutting of Inconel 718

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Bing Wang

2018-03-01

Full Text Available The paper aims to investigate the influences of material constitutive and fracture parameters in addition to cutting speed on chip formation during high-speed cutting of Inconel 718. Finite element analyses for chip formation are conducted with Johnson–Cook constitutive and fracture models. Meanwhile, experiments of high-speed orthogonal cutting are performed to verify the simulation results with cutting speeds ranging from 50 m/min to 7000 m/min. The research indicates that the chip morphology transforms from serrated to fragmented at the cutting speed of 7000 m/min due to embrittlement of the workpiece material under ultra-high cutting speeds. The parameter of shear localization sensitivity is put forward to describe the influences of material mechanical properties on serrated chip formation. The results demonstrate that the effects of initial yield stress and thermal softening coefficient on chip shear localization are much more remarkable than the other constitutive parameters. For the material fracture parameters, the effects of initial fracture strain and exponential factor of stress state on chip shear localization are more much prominent. This paper provides guidance for controlling chip formation through the adjustment of material mechanical properties and the selection of appropriate cutting parameters.

Influences of Cutting Speed and Material Mechanical Properties on Chip Deformation and Fracture during High-Speed Cutting of Inconel 718.

Science.gov (United States)

Wang, Bing; Liu, Zhanqiang; Hou, Xin; Zhao, Jinfu

2018-03-21

The paper aims to investigate the influences of material constitutive and fracture parameters in addition to cutting speed on chip formation during high-speed cutting of Inconel 718. Finite element analyses for chip formation are conducted with Johnson-Cook constitutive and fracture models. Meanwhile, experiments of high-speed orthogonal cutting are performed to verify the simulation results with cutting speeds ranging from 50 m/min to 7000 m/min. The research indicates that the chip morphology transforms from serrated to fragmented at the cutting speed of 7000 m/min due to embrittlement of the workpiece material under ultra-high cutting speeds. The parameter of shear localization sensitivity is put forward to describe the influences of material mechanical properties on serrated chip formation. The results demonstrate that the effects of initial yield stress and thermal softening coefficient on chip shear localization are much more remarkable than the other constitutive parameters. For the material fracture parameters, the effects of initial fracture strain and exponential factor of stress state on chip shear localization are more much prominent. This paper provides guidance for controlling chip formation through the adjustment of material mechanical properties and the selection of appropriate cutting parameters.

Multivariable Techniques for High-Speed Research Flight Control Systems

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Newman, Brett A.

1999-01-01

This report describes the activities and findings conducted under contract with NASA Langley Research Center. Subject matter is the investigation of suitable multivariable flight control design methodologies and solutions for large, flexible high-speed vehicles. Specifically, methodologies are to address the inner control loops used for stabilization and augmentation of a highly coupled airframe system possibly involving rigid-body motion, structural vibrations, unsteady aerodynamics, and actuator dynamics. Design and analysis techniques considered in this body of work are both conventional-based and contemporary-based, and the vehicle of interest is the High-Speed Civil Transport (HSCT). Major findings include: (1) control architectures based on aft tail only are not well suited for highly flexible, high-speed vehicles, (2) theoretical underpinnings of the Wykes structural mode control logic is based on several assumptions concerning vehicle dynamic characteristics, and if not satisfied, the control logic can break down leading to mode destabilization, (3) two-loop control architectures that utilize small forward vanes with the aft tail provide highly attractive and feasible solutions to the longitudinal axis control challenges, and (4) closed-loop simulation sizing analyses indicate the baseline vane model utilized in this report is most likely oversized for normal loading conditions.

Diffusion tensor imaging of the median nerve at 3.0 T using different MR scanners: Agreement of FA and ADC measurements

International Nuclear Information System (INIS)

Guggenberger, Roman; Nanz, Daniel; Bussmann, Lorenz; Chhabra, Avneesh; Fischer, Michael A.; Hodler, Jürg; Pfirrmann, Christian W.A.; Andreisek, Gustav

2013-01-01

Objective: To assess the agreement of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the median nerve on 3.0 T MR scanners from different vendors. Materials and methods: IRB approved study including 16 healthy volunteers (9 women; mean age 30.6 ± 5.3 years). Diffusion tensor imaging (DTI) of the dominant wrist was performed on three 3.0 T MR scanners (GE, Siemens, Philips) using similar imaging protocols and vendor-proprietary hard- and software. Intra-, inter-reader and inter-vendor agreements were assessed. Results: ICCs for intra-/inter-reader agreements ranged from 0.843–0.970/0.846–0.956 for FA, and 0.840–0.940/0.726–0.929 for ADC, respectively. ANOVA analysis identified significant differences for FA/ADC measurements among vendors (p −3 mm 2 /s (SD ± 0.134 × 10 −3 ) for ADC. A significant negative measurement bias was found for FA values from the GE scanner (−0.05 and −0.07) and for ADC values from the Siemens scanner (−0.053 and −0.063 × 10 −3 mm 2 /s) as compared to the remainder vendors Conclusion: FA and ADC values of the median nerve obtained on different 3.0 T MR scanners differ significantly, but are in comparison to the standard deviation of absolute values small enough to not have an impact on larger group studies or when substantial diffusion changes can be expected. However, caution is warranted in an individual patient when interpreting diffusion values from different scanner acquisitions

High Speed and High Spatial Density Parameter Measurement Using Fiber Optic Sensing Technology

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Parker, Allen R. Jr. (Inventor); Chan, Hon Man (Inventor); Richards, William Lance (Inventor); Piazza, Anthony (Inventor); Hamory, Philip J (Inventor)

2017-01-01

The present invention is an improved fiber optic sensing system (FOSS) having the ability to provide both high spatial resolution and high frequency strain measurements. The inventive hybrid FOSS fiber combines sensors from high acquisition speed and low spatial resolution Wavelength-Division Multiplexing (WDM) systems and from low acquisition speed and high spatial resolution Optical Frequency Domain Reflection (OFDR) systems. Two unique light sources utilizing different wavelengths are coupled with the hybrid FOSS fiber to generate reflected data from both the WDM sensors and OFDR sensors operating on a single fiber optic cable without incurring interference from one another. The two data sets are then de-multiplexed for analysis, optionally with conventionally-available WDM and OFDR system analyzers.

High-speed imaging polarimetry using liquid crystal modulators

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Ambs P.

2010-06-01

Full Text Available This paper deals with dynamic polarimetric imaging techniques. The basics of modern polarimetry have been known for one and a half century, but no practical high-speed implementation providing the full polarization information is currently available. Various methods are reviewed which prove to be a trade-off between the complexity of the optical set-up and the amount of polarimetric information they provide (ie the number of components of the Stokes vector. Techniques using liquid crystal devices, incepted in the late 1990's, are emphasized. Optical set-ups we implemented are presented. We particularly focus on high-speed techniques (i.e. faster than 200 Hz using ferroelectric liquid crystal devices.

Error mapping of high-speed AFM systems

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Klapetek, Petr; Picco, Loren; Payton, Oliver; Yacoot, Andrew; Miles, Mervyn

2013-02-01

In recent years, there have been several advances in the development of high-speed atomic force microscopes (HSAFMs) to obtain images with nanometre vertical and lateral resolution at frame rates in excess of 1 fps. To date, these instruments are lacking in metrology for their lateral scan axes; however, by imaging a series of two-dimensional lateral calibration standards, it has been possible to obtain information about the errors associated with these HSAFM scan axes. Results from initial measurements are presented in this paper and show that the scan speed needs to be taken into account when performing a calibration as it can lead to positioning errors of up to 3%.

Pulsed laser triggered high speed microfluidic switch

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Wu, Ting-Hsiang; Gao, Lanyu; Chen, Yue; Wei, Kenneth; Chiou, Pei-Yu

2008-10-01

We report a high-speed microfluidic switch capable of achieving a switching time of 10 μs. The switching mechanism is realized by exciting dynamic vapor bubbles with focused laser pulses in a microfluidic polydimethylsiloxane (PDMS) channel. The bubble expansion deforms the elastic PDMS channel wall and squeezes the adjacent sample channel to control its fluid and particle flows as captured by the time-resolved imaging system. A switching of polystyrene microspheres in a Y-shaped channel has also been demonstrated. This ultrafast laser triggered switching mechanism has the potential to advance the sorting speed of state-of-the-art microscale fluorescence activated cell sorting devices.

Magneto-optical system for high speed real time imaging

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Baziljevich, M.; Barness, D.; Sinvani, M.; Perel, E.; Shaulov, A.; Yeshurun, Y.

2012-08-01

A new magneto-optical system has been developed to expand the range of high speed real time magneto-optical imaging. A special source for the external magnetic field has also been designed, using a pump solenoid to rapidly excite the field coil. Together with careful modifications of the cryostat, to reduce eddy currents, ramping rates reaching 3000 T/s have been achieved. Using a powerful laser as the light source, a custom designed optical assembly, and a high speed digital camera, real time imaging rates up to 30 000 frames per seconds have been demonstrated.

Observation of the dynamic movement of fragmentations by high-speed camera and high-speed video

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Suk, Chul-Gi; Ogata, Yuji; Wada, Yuji; Katsuyama, Kunihisa

1995-05-01

The experiments of blastings using mortal concrete blocks and model concrete columns were carried out in order to obtain technical information on fragmentation caused by the blasting demolition. The dimensions of mortal concrete blocks were 1,000 X 1,000 X 1,000 mm. Six kinds of experimental blastings were carried out using mortal concrete blocks. In these experiments precision detonators and No. 6 electric detonators with 10 cm detonating fuse were used and discussed the control of fragmentation. As the results of experiment it was clear that the flying distance of fragmentation can be controlled using a precise blasting system. The reinforced concrete model columns for typical apartment houses in Japan were applied to the experiments. The dimension of concrete test column was 800 X 800 X 2400 mm and buried 400 mm in the ground. The specified design strength of the concrete was 210 kgf/cm2. These columns were exploded by the blasting with internal loading of dynamite. The fragmentation were observed by two kinds of high speed camera with 500 and 2000 FPS and a high speed video with 400 FPS. As one of the results in the experiments, the velocity of fragmentation, blasted 330 g of explosive with the minimum resisting length of 0.32 m, was measured as much as about 40 m/s.

High speed cryogenic self-acting, shaft seals for liquid rocket turbopumps

Science.gov (United States)

Burcham, R. E.

1983-01-01

Three self acting lift pad liquid oxygen face seals and two self acting gaseous helium circumferential seals for high speed liquid oxygen turbopump were evaluated. The development of a technology for reliable, 10 hour life, multiple start seals for use in high speed liquid oxygen turbopumps is discussed.

SiGe 130 nm-based Rad-Hard ADC for the JEO Mission, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Ridgetop will demonstrate the feasibility of developing a radiation-hardened analog-to-digital converter (ADC) suitable for the Jupiter Europa Orbiter mission. This...

IMITATION MODEL OF A HIGH-SPEED INDUCTION MOTOR WITH FREQUENCY CONTROL

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V. E. Pliugin

2017-12-01

Full Text Available Purpose. To develop the imitation model of the frequency converter controlled high-speed induction motor with a squirrel-cage rotor in order to determine reasons causes electric motor vibrations and noises in starting modes. Methodology. We have applied the mathematical simulation of electromagnetic field in transient mode and imported obtained field model as an independent object in frequency converter circuit. We have correlated the simulated result with the experimental data obtained by means of the PID regulator factors. Results. We have made the simulation model of the high-speed induction motor with a squirrel-cage rotor speed control in AnsysRMxprt, Ansys Maxwell and Ansys Simplorer, approximated to their physical prototype. We have made models modifications allows to provide high-performance computing (HPC in dedicated server and computer cluster to reduce the simulation time. We have obtained motor characteristics in starting and rated modes. This allows to make recommendations on determination of high-speed electric motor optimal deign, having minimum indexes of vibrations and noises. Originality. For the first time, we have carried out the integrated research of induction motor using simultaneously simulation models both in Ansys Maxwell (2D field model and in Ansys Simplorer (transient circuit model with the control low realization for the motor soft start. For the first time the correlation between stator and rotor slots, allows to obtain minimal vibrations and noises, was defined. Practical value. We have tested manufactured high-speed motor based on the performed calculation. The experimental studies have confirmed the adequacy of the model, which allows designing such motors for new high-speed construction, and upgrade the existing ones.

High speed imaging system for nuclear diagnostics

International Nuclear Information System (INIS)

Eyer, H.H.

1976-01-01

A high speed imaging system based on state-of-the-art photosensor arrays has been designed for use in nuclear diagnostics. The system is comprised of a front-end rapid-scan solid-state camera, a high speed digitizer, and a PCM line driver in a downhole package and a memory buffer system in a uphole trailer. The downhole camera takes a ''snapshot'' of a nuclear device created flux stream, digitizes the image and transmits it to the uphole memory system before being destroyed. The memory system performs two functions: it retains the data for local display and processing by a microprocessor, and it buffers the data for retransmission at slower rates to the LLL computational facility (NADS). The impetus for such a system as well as its operation are discussed. Also discussed are new systems under development which incorporate higher data rates and more resolution