Derivation of P-T paths from high-pressure metagranites - Examples from the Gran Paradiso Massif, western Alps

Science.gov (United States)

Massonne, Hans-Joachim

2015-06-01

Metamorphosed granites (SiO2 ≥ 70 wt.%) are, in fact, a common rock type in high pressure (HP) and ultrahigh pressure (UHP) terrains, but these rocks were rarely used to derive metamorphic P-T paths. To test the suitability of HP metagranites for such derivations, two metagranites from the Gran Paradiso Massif were studied applying elemental mapping of phengite and garnet and calculated P-T pseudosections contoured by various chemical and modal parameters. Both rocks contain phengite with maximum Si contents of about 3.42 Si per formula unit (pfu) and 3.55 Si pfu in cores, and accessory garnet which is compositionally zoned. Garnet core compositions are rich in grossular component (XCa up to 0.72). Only a rough P-T path could be derived with peak pressures below 2 GPa because, for instance, Si contents in phengite become geobarometrically insensitive at HP conditions, when biotite is not anymore stable. A test of the pseudosection approach to a metagranite from the North Qaidam UHP metamorphic belt resulted in an ambiguous finding. In fact, compositions of garnet and phengite in this rock are indicative of both UHP and specific HP conditions ( 1.3 GPa, 530 °C), but the latter conditions fit the entire mineralogical observations better.

Study of high-$p_T$ hadron-jet correlations in ALICE

CERN Document Server

Křížek, Filip

2015-01-01

Jets provide unique probes of the medium created in ultrarelativistic heavy-ion collisions. Here, the observed jet quenching phenomena in central collisions prove that jets are sensitive to interesting properties of strongly-coupled matter. In addition, jet production in elementary processes, such as pp collisions, is well understood within the framework of perturbative QCD, providing a rigorous theoretical basis for jet quenching calculations. We report the measurement of semi-inclusive p T spectra of charged particle jets that recoil from a high- p T hadron trigger in Pb–Pb and pp collisions at √ s NN = 2 : 76 TeV and √ s = 7 TeV, respectively. In this analysis, the copious yield of uncorrelated trigger hadron-jet matchings in central Pb–Pb collisions is removed by calculating the difference between two spectra corresponding to disjoint trigger hadron p T ranges. This procedure does not impose any fragmentation bias on the recoil jet population, which is thus collinear and infrared safe

Studying High pT muons in Cosmic-Ray Air Showers

International Nuclear Information System (INIS)

Klein, Spencer R.

2006-01-01

Most cosmic-ray air shower arrays have focused on detecting electromagnetic shower particles and low energy muons. A few groups (most notably MACRO + EASTOP and SPASE + AMANDA) have studied the high energy muon component of showers. However, these experiments had small solid angles, and did not study muons far from the core. The IceTop + IceCube combination, with its 1 km 2 muon detection area can study muons far from the shower core. IceCube can measure their energy loss (dE/dx), and hence their energy. With the energy, and the known distribution of production heights, the transverse momentum (p T ) spectrum of high p T muons can be determined. The production of the semuons is calculable in perturbative QCD, so the measured muon spectra can be used to probe the composition of incident cosmic-rays

High-$p_{T}$ direct photon production in pp collisions

CERN Document Server

Anassontzis, E; Ferbel, T; Karabarbounis, A; Kourkoumelis, C; Lissauer, D; Mannelli, I; Molzon, W; Mouzourakis, P; Nappi, A; Palmer, R B; Rahm, David Charles; Rehak, P; Resvanis, L K; Rosso, E; Stumer, I; Willis, W

1982-01-01

Direct photon and neutral-pion production have been measured in pp collisions at the CERN ISR for 30< \\sqrt{s}<63 GeV and transverse momenta up to 12 GeV/c. The direct photon signal relative to neutral- pion production increases with p/sub T/ and shows little \\sqrt{s}-dependence. Results are reported from a variety of running conditions, and details are given on the method of analysis and on the evaluation of systematic errors for the inclusive cross-section of single-photon and neutral-pion production.

Looking for DPS patterns using $J / \\psi$ and high $p_{T}$ tracklets

CERN Document Server

Thabt, Ahmed Mustafa Aboelfadl; Stocco, Diego; Palni, Prabhakar; CERN. Geneva. Department

2017-01-01

We present a standalone analysis of p-p collisions at $ \\sqrt{s} = 5.02 $ TeV for $ J/\\psi $ decaying into dimuons and also a feasibility study of $ p_{T} $ correlations with different observables of tracklets in the central barrel. In the latter analysis, it was found that both $ \\delta \\phi $ and $ \\chi^{2} $ (dist) could be used efficiently to select high $ p_{T} $ tracklets. These analyses are then implemented in studying the Double Parton Scattering with $ J/\\psi $ and two jets to estimate the effective cross section parameter.

Survival of high pT light and heavy flavors in a dense medium

International Nuclear Information System (INIS)

Kopeliovich, B. Z.

2011-01-01

This talk presents an attempt at a critical overview of the current status of modeling for high-p T processes in nuclei. In particular, it includes discussion of the space-time development of hadronization of highly virtual light and heavy partons, and the related time scales; the role of early production and subsequent attenuation of pre-hadrons in a dense medium. We identify several challenging problems within the current interpretation of high-p T processes and propose solutions for some of them.

Boundary conditions in Ginsburg Landau theory and critical temperature of high-T superconductors

Science.gov (United States)

Lykov, A. N.

2008-06-01

New mixed boundary conditions to the Ginsburg-Landau equations are found to limit the critical temperature ( T) of high- T superconductors. Moreover, the value of the pseudogap in these superconductors can be explained by using the method. As a result, the macroscopic approach is proposed to increase T of cuprate superconductors.

High-pT Jet Energy Scale Uncertainty from single hadron response with the ATLAS detector

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00534683; The ATLAS collaboration

2016-01-01

The jet energy scale (JES) uncertainty is estimated using different methods at different p$_\\text{T}$ ranges. In-situ techniques exploiting the p$_\\text{T}$ balance between a jet and a reference object (e.g. Z or gamma) are used at lower p$_\\text{T}$, but at very high p$_\\text{T}$ (> 2.5 TeV) there is not enough statistics for such in-situ techniques. A low JES uncertainty at high-p$_\\text{T}$ is important in several searches for new phenomena, e.g. the dijet resonance and angular searches. In the highest p$_\\text{T}$ range, the JES uncertainty is estimated using the calorimeter response to single hadrons. In this method, jets are treated as a superposition of energy depositions of single particles. An uncertainty is applied to each energy deposition belonging to the particles within the jet, and propagated to the final jet energy scale. This poster presents the JES uncertainty found with this method at sqrt(s) = 8 TeV and its developments.

Centrality dependence of low-\\p_{T} and high-p_{T} particle production in proton--lead collisions with ATLAS.

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00287239; The ATLAS collaboration

2015-01-01

Measurements of the centrality dependence of low-p_{T} and high-p_{T} particle production in proton-lead collisions at the LHC can provide unique insight into the dynamics of soft and hard scattering processes and the initial state of ultra-relativistic nuclear collisions. Recent results have shown that both soft and hard processes may be significantly influenced by event-to-event fluctuations (variations) in the structure of the proton. In this proceedings, the latest measurements of the centrality dependence of charged particle, and Z boson production with the ATLAS detector at the LHC are used to explore these questions. In particular, the sensitivity of the charged particle pseudorapidity distribution in proton--lead collisions to the choice of centrality variable is discussed. Separately, to address recent measurements of the correlation between the initial-state hard scattering kinematics in dijet events and forward transverse energy in proton-proton collisions will be presented.

Jets and high pT hadrons in dense matter: recent results from STAR

International Nuclear Information System (INIS)

Jacobs, Peter; Klay, Jennifer

2004-01-01

We review recent measurements of high transverse momentum (high pT) hadron production in nuclear collisions by the STAR Collaboration at RHIC. The previously observed suppression in central Au+Au collisions has been extended to much higher pT. New measurements from d+Au collisions are presented which help disentangle the mechanisms responsible for the suppression. Inclusive single hadron spectra are enhanced in d+Au relative to p+p, while two-particle azimuthal distributions are observed to be similar in p+p, d+Au and peripheral Au+Au collisions. The large suppression of inclusive hadron production and absence of the away-side jet-like correlations in central Au+Au collisions are shown to be due to interactions of the jets with the very dense medium produced in these collisions

Tectono-metamorphic evolution of high-P/T and low-P/T metamorphic rocks in the Tia Complex, southern New England Fold Belt, eastern Australia: Insights from K-Ar chronology

Science.gov (United States)

Fukui, Shiro; Tsujimori, Tatsuki; Watanabe, Teruo; Itaya, Tetsumaru

2012-10-01

The Tia Complex in the southern New England Fold Belt is a poly-metamorphosed Late Paleozoic accretionary complex. It consists mainly of high-P/low-T type pumpellyite-actinolite facies (rare blueschist facies) schists, phyllite and serpentinite (T = 300 °C and P = 5 kbar), and low-P/high-T type amphibolite facies schist and gneiss (T = 600 °C and P Tia granodiorite). White mica and biotite K-Ar ages distinguish Carboniferous subduction zone metamorphism and Permian granitic intrusions, respectively. The systematic K-Ar age mapping along a N-S traverse of the Tia Complex exhibits a gradual change. The white mica ages become younger from the lowest-grade zone (339 Ma) to the highest-grade zone (259 Ma). In contrast, Si content of muscovite changes drastically only in the highest-grade zone. The regional changes of white mica K-Ar ages and chemical compositions of micas indicate argon depletion from precursor high-P/low-T type phengitic white mica during the thermal overprinting and recrystallization by granitoids intrusions. Our new K-Ar ages and available geological data postulate a model of the eastward rollback of a subduction zone in Early Permian. The eastward shift of a subduction zone system and subsequent magmatic activities of high-Mg andesite and adakite might explain formation of S-type granitoids (Hillgrove suite) and coeval low-P/high-T type metamorphism in the Tia Complex.

Summary of discussions at the ''HIGH pT'' session

International Nuclear Information System (INIS)

Tannenbaum, M.J.

1990-12-01

A summary of the discussion at the HIGH p T session is presented. There was a clear consensus at this session that Jets and Jet Phenomena in Relativistic Heavy Ion collisions would best be studied using leading particles, in the same way that these phenomena were originally mapped out in p-p collisions. The new topic of ''Jet Quenching in Nuclei'' was extensively discussed. It was clear that this proposed phenomenon could also be studied by measuring fragmentation functions in Deeply Inelastic Lepton-Nucleus Scattering; but there was controversy over whether the effect should be seen in proton-Nucleus reactions. Other hard-scattering phenomena, including ''Mini-jets,'' single particle inclusive production, the ''Cronin Effect,'' and direct photon production, are mentioned. 26 refs., 3 figs

P-T-t metamorphic evolution of highly deformed metapelites from the Pinkie unit of western Svalbard using quartz-in-garnet barometry, trace element thermometry, P-T-X-M diagrams and monazite in-situ dating

Science.gov (United States)

Kośmińska, Karolina; Spear, Frank; Majka, Jarosław

2017-04-01

We present the results of quartz-in-garnet (QuiG) Raman barometry coupled with P-T-X-M diagrams, trace element thermometry, and monazite dating from metapelites of the Pinkie unit on Prins Karls Forland, western Svalbard. This unconventional approach, which combines traditional and novel thermobarometry techniques as well as dating results, provides the opportunity to decipher the pressure-temperature-time (P-T-t) metamorphic evolution of these highly deformed rocks, for which the P-T conditions could not have been obtained using traditional techniques. The Pinkie unit is comprised of Barrovian-type zones expressed by the following three mineral assemblages: Grt+St+Ms+Bt+Pl+Q, Grt+St+Ky+Ms+Bt+Pl+Q and Grt+Ky+Ms+Bt+Pl+Q. The metamorphic assemblages have been strongly affected by pervasive mylonitization. Two generations of garnet are present. Early garnet-I forms large (up to 2 mm) anhedral and inclusion-rich porphyroblasts that are strongly deformed with resorbed rims. Its composition varies from Alm81Grs5Prp11Sps3 in the core to Alm84Grs4Prp10Sps2 in the rim for a St-bearing sample. St-Ky bearing metapelites contain garnet-I, which is characterized by Alm88Grs2Prp8Sps2 in the core and Alm89Grs2Prp8Sps1 in the rim. In the Ky-bearing sample garnet-I composition is varying from Alm77Grs4Prp11Sps8 in the core to Alm83Grs4Prp9Sps4 in the rim. Garnet-II is characterized by small (up to 0.5 mm) euhedral grains that locally overgrows garnet-I. It contains very scarce inclusions, mostly quartz. Grt-II composition is very similar in all Pinkie unit samples and is characterized by Alm80Grs11Prp8Sps1(0). The measured maximum shift of the 464 cm-1 Raman band for quartz in garnet-I is 1.05 cm-1 for St-bearing samples, 1.80 cm-1 for St-Ky bearing rocks, and 2.10 cm-1 for Ky-bearing samples, respectively. The highest shift obtained for inclusions in garnet-II is 2.7 cm-1. Monazite-in-garnet thermometry combined with the QuiG yielded P-T conditions of garnet-I nucleation as

Estimation of high-pT Jet Energy Scale Uncertainty from single hadron response with the ATLAS detector

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00534683; The ATLAS collaboration

2016-01-01

The jet energy scale (JES) uncertainty is estimated using different methods at different pT ranges. In situ techniques exploiting the pT balance between a jet and a reference object (e.g. Z or gamma) are used at lower pT, but at very high pT (> 2.5 TeV) there is not enough statistics for in-situ techniques. The JES uncertainty at high-pT is important in several searches for new phenomena, e.g. the dijet resonance and angular searches. In the highest pT range, the JES uncertainty is estimated using the calorimeter response to single hadrons. In this method, jets are treated as a superposition of energy depositions of single particles. An uncertainty is applied to each energy depositions belonging to the particles within the jet, and propagated to the final jet energy scale. This poster presents the JES uncertainty found with this method at sqrt(s) = 8 TeV and its developments.

Self-similarity of high-pT hadron production in π-p and π- A collisions

International Nuclear Information System (INIS)

Tokarev, M.V.; Panebrattsev, Yu.A.; Skoro, G.P.; Zborovsky, I.

2002-01-01

Self-similar properties of hadron production in π - p and π - A collisions over a high-p T region are studied. The analysis if experimental data is performed in the framework of z-scaling. The scaling variable depends on the anomalous fractal dimension of the incoming pion. Its value is found to be δ π ≅ 0.1. Independence of the scaling function Ψ(z) on the collision energy is shown. A-dependence of data z-presentation confirms self-similarity of particle formation in πA collisions

Centrality dependence of low-p{sub T} and high-p{sub T} particle production in proton–lead collisions with ATLAS

Energy Technology Data Exchange (ETDEWEB)

Shulga, Evgeny

2016-12-15

Measurements of the centrality dependence of low-p{sub T} and high-p{sub T} particle production in proton-lead collisions at the LHC can provide unique insight into the dynamics of soft and hard scattering processes and the initial state of ultra-relativistic nuclear collisions. Recent results have shown that both soft and hard processes may be significantly influenced by event-to-event fluctuations (variations) in the structure of the proton. In this proceedings, the latest measurements of the centrality dependence of charged particle, and Z boson production with the ATLAS detector at the LHC are used to explore these questions. In particular, the sensitivity of the charged particle pseudorapidity distribution in proton–lead collisions to the choice of centrality variable is discussed. Separately, to address recent measurements of the correlation between the initial-state hard scattering kinematics in dijet events and forward transverse energy in proton-proton collisions will be presented.

Centrality dependence of low-$p_{_\\text{T}}$ and high-$p_{_\\text{T}}$ particle production in proton--lead collisions with ATLAS

CERN Document Server

Shulga, Evgeny; The ATLAS collaboration

2015-01-01

Measurements of the centrality dependence of low-$p_{_\\text{T}}$ and high-$p_{_\\text{T}}$ particle production in proton-lead collisions at the LHC can provide unique insight into the dynamics of soft and hard scattering processes and the initial state of ultra-relativistic nuclear collisions. Recent results have shown that both soft and hard processes may be significantly influenced by event-to-event fluctuations (variations) in the structure of the proton. In this talk, the latest measurements of the centrality dependence of charged particle, jet, and Z boson production with the ATLAS detector at the LHC will be used to explore these questions. In particular, the sensitivity of the charged particle pseudorapidity distribution in proton--lead collisions to the choice of centrality variable will be discussed. Separately, the strong centrality dependence of jet production in proton--lead collisions has raised questions about energy production at large rapidities in collisions involving a large proton-x. To addr...

Recent results of high p(T) physics at the CDF II

Energy Technology Data Exchange (ETDEWEB)

Tsuno, Soushi; /Okayama U.

2005-02-01

The Tevatron Run II program has been in progress since 2001. The CDF experiment has accumulated roughly five times as much data as did Run I, with much improved detectors. Preliminary results from the CDF experiment are presented. The authors focus on recent high p{sub T} physics results in the Tevatron Run II program.

Hadron correlation in jets on the near and away sides of high-pT triggers in heavy-ion collisions

International Nuclear Information System (INIS)

Hwa, Rudolph C.; Yang, C. B.

2009-01-01

The correlation between the trigger and associated particles in jets produced on near and away sides of high-p T triggers in heavy-ion collisions is studied. Hadronization of jets on both sides is treated by thermal-shower and shower-shower recombinations. The energy loss of semihard and hard partons traversing the nuclear medium is parametrized in a way that renders a good fit of the single-particle inclusive distributions at all centralities. The associated hadron distribution in the near-side jet can be determined showing weak dependence on system size because of trigger bias. The inverse slope increases with trigger momentum in agreement with data. The distribution of associated particles in the away-side jet is also studied with careful attention given to antitrigger bias that is due to the longer path length that the away-side jet recoiling against the trigger jet must propagate in the medium to reach the opposite side. Centrality dependence is taken into account after determining a realistic probability distribution of the dynamical path length of the parton trajectory within each class of centrality. For symmetric dijets with p T trig =p T assoc (away), it is shown that the per-trigger yield is dominated by tangential jets. For unequal p T trig , p T assoc (near) and p T assoc (away), the yields are calculated for various centralities, showing an intricate relationship among them. The near-side yield agrees with data both in centrality dependence and in p T assoc (near) distribution. The average parton momentum for the recoil jet is shown to be always larger than that of the trigger jet for fixed p T trig and centrality and for any measurable p T assoc (away). With the comprehensive treatment of dijet production described here, it is possible to answer many questions regarding the behavior of partons in the medium under conditions that can be specified on measurable hadron momenta.

High pT jet production in pp collisions

International Nuclear Information System (INIS)

Eskola, K.J.; Wang, X.N.

1995-01-01

Production rates of large p T jets in pp collisions at RHIC and LHC energies are studied using the next-to-leading order calculation of S. D. Ellis, Z. Zunszt and D. Soper. The computed inclusive one-jet cross sections are compared against the CERN and Fermilab jet data from p bar p and pp collisions. The dependence of the results on the choice of the parton distributions and renormalization/factorization scales is investigated

Jan Rak and Michael J. Tannenbaum present the book "High-pT physics in the heavy ion era"

CERN Multimedia

2013-01-01

Thursday 13 June 2013 from 4 p.m. to 5 p.m. in the Library, Bldg. 52 1-052 The book provides an overview of the basic concepts of large transverse momentum particle physics, with a focus on pQCD phenomena. It examines high-pT probes of relativistic heavy-ion collisions and will serve as a handbook for those working on RHIC and LHC data analyses. Starting with an introduction and review of the field, the authors look at basic observables and experimental techniques, concentrating on relativistic particle kinematics, before moving onto a discussion about the origins of high-pT physics. The main features of high-pT physics are placed within a historical context and the authors adopt an experimental outlook, highlighting the most important discoveries leading up to the foundation of modern QCD theory. High-pT physics in the heavy ion era, by Jan Rak and Michael J. Tannenbaum,  Cambridge University Press, 2013, ISBN  9780521190299. *Coffee will be served from 3 p.m.*

A quasi-model-independent search for new high pT physics at DO

International Nuclear Information System (INIS)

Knuteson, Bruce O.

2000-01-01

We present a new quasi-model-independent strategy (''Sleuth'') for searching for physics beyond the standard model. We define final states to be studied, and construct a rule that identifies a set of relevant variables for any particular final state. A novel algorithm searches for regions of excess in those variables and quantifies the significance of any detected excess. This strategy is applied to search for new high p T physics in approximately 100 pb -1 of proton-anti-proton collisions at sqrt(s) = 1.8 TeV collected by the D0 experiment during 1992-1996 at the Fermilab Tevatron. We systematically analyze many exclusive final states, and demonstrate sensitivity to a variety of models predicting new phenomena at the electroweak scale. No evidence of new high p T physics is observed

Study of the reaction D(p,π+)T at T/sub p/ = 410, 605, and 809 MeV

International Nuclear Information System (INIS)

Aslanides, E.; Bertini, R.; Bing, O.; Brochard, F.; Gorodetzky, P.; Hibou, F.; Bauer, T.S.; Beurtey, R.; Boudard, A.; Bruge, G.; Catz, H.; Chaumeaux, A.; Couvert, P.; Duhm, H.H.; Garreta, D.; Igo, G.; Lugol, J.C.; Matoba, M.; Terrien, Y.; Bimbot, L.; Le Bornec, Y.; Tatischeff, B.

1977-01-01

Pion production on a CD 2 target has been measured using the high-resolution magnetic spectrometer SPES I. Differential cross section for the reaction D(p,π + )T have been determined at T/sub p/ = 410, 605, and 809 MeV. The present data, together with previous results establish a complete angular distribution of the reaction D(p,π + )T at approx. 600 MeV and energy dependence of the differential cross section for this reaction at several constant momentum transfers

High spin states excited by the (p, t) reaction on lead isotopes

Energy Technology Data Exchange (ETDEWEB)

Kumabe, I.; Hyakutake, M. [Kyushu Univ., Fukuoka (Japan). Faculty of Engineering; Yuasa, K.; Yamagata, T.; Kishimoto, S.; Ikegami, H.; Muraoka, M [eds.

1980-01-01

In order to find high spin states the sup(204, 206, 208)Pb (p, t) reactions have been investigated with RCNP isochronous cyclotron and a high resolution magnetic spectrograph ''RAIDEN''. The experimental angular distributions were analyzed by DWBA calculations, and the lowest 10/sup +/, 12/sup +/ (i sub(13/2))/sup 2/ and 11/sup -/ (i sub(13/2), h sub(9/2)) states in /sup 202/Pb, /sup 204/Pb and /sup 206/Pb were established.

p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.

Science.gov (United States)

Cereseto, A; Diella, F; Mulloy, J C; Cara, A; Michieli, P; Grassmann, R; Franchini, G; Klotman, M E

1996-09-01

Human T-cell lymphotropic/leukemia virus type I (HTLV-I) is associated with T-cell transformation both in vivo and in vitro. Although some of the mechanisms responsible for transformation remain unknown, increasing evidence supports a direct role of viral as well as dysregulated cellular proteins in transformation. We investigated the potential role of the tumor suppressor gene p53 and of the p53-regulated gene, p21waf1/cip1 (wild-type p53 activated fragment 1/cycling dependent kinases [cdks] interacting protein 1), in HTLV-I-infected T cells. We have found that the majority of HTLV-I-infected T cells have the wild-type p53 gene. However, its function in HTLV-I-transformed cells appears to be impaired, as shown by the lack of appropriate p53-mediated responses to ionizing radiation (IR). Interestingly, the expression of the p53 inducible gene, p21waf1/cip1, is elevated at the messenger ribonucleic acid and protein levels in all HTLV-I-infected T-cell lines examined as well as in Taxl-1, a human T-cell line stably expressing Tax. Additionally, Tax induces upregulation of a p21waf1/cip1 promoter-driven luciferase gene in p53 null cells, and increases p21waf1/cip1 expression in Jurkat T cells. These findings suggest that the Tax protein is at least partially responsible for the p53-independent expression of p21waf1/cip1 in HTLV-I-infected cells. Dysregulation of p53 and p21waf1/cip1 proteins regulating cell-cycle progression, may represent an important step in HTLV-I-induced T-cell transformation.

Evidence of final-state suppression of high-p{_ T} hadrons in Au + Au collisions using d + Au measurements at RHIC

Science.gov (United States)

Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Becker, B.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Harrington, A. S.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lee, J. W.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Pernegger, H.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Sarin, P.; Sedykh, I.; Skulski, W.; Smith, C. E.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Verdier, R.; Veres, G. I.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wysłouch, B.; Zhang, J.

Transverse momentum spectra of charged hadrons with pT 2 GeV/c). In contrast, the d + Au nuclear modification factor exhibits no suppression of the high-pT yields. These measurements suggest a large energy loss of the high-pT particles in the highly interacting medium created in the central Au + Au collisions. The lack of suppression in d + Au collisions suggests that it is unlikely that initial state effects can explain the suppression in the central Au + Au collisions. PACS: 25.75.-q

Study of 162Er via the (p , t) and (p ,p') reactions

Science.gov (United States)

Kisliuk, D.; Garrett, P. E.; Finlay, A.; Bianco, L.; Bildstein, V.; Burbadge, C.; Chagnon-Lessard, S.; Diaz Varela, A.; Dunlop, M. R.; Dunlop, R.; Finlay, P.; Jamieson, D.; Jigmeddorj, B.; Maclean, A. D.; Michetti-Wilson, J.; Leach, K. G.; Radich, A. J.; Rand, E.; Svensson, C. E.; Wong, J.; Ball, G. C.; Triambak, S.; Faestermann, T.; Hertenberger, R.; Wirth, H.-F.

2015-10-01

The nature of excited states in well-deformed nuclei pose a challenge in nuclear structure. In light of this, the study of 162Er via the 164Er (p , t) and 162Er (p ,p') reactions has been initiated to shed light on the structure of these excited states. The experiments were performed at the Maier-Leibnitz Laboratory using a 22 MeV proton beam on highly-enriched targets of 162,164Er and the reaction was analyzed with the Q3D spectrograph. Strong population in the (p , t) reaction of the 02+ state, far greater than other 0+ states, has been observed. Transition matrix elements for population of low-lying states in the (p ,p') reaction have also been extracted. Initial results from these experiments will be presented.

Re-evaluation of P-T paths across the Himalayan Main Central Thrust

Science.gov (United States)

Catlos, E. J.; Harrison, M.; Kelly, E. D.; Ashley, K.; Lovera, O. M.; Etzel, T.; Lizzadro-McPherson, D. J.

2016-12-01

The Main Central Thrust (MCT) is the dominant crustal thickening structure in the Himalayas, juxtaposing high-grade Greater Himalayan Crystalline rocks over the lower-grade Lesser Himalaya Formations. The fault is underlain by a 2 to 12-km-thick sequence of deformed rocks characterized by an apparent inverted metamorphic gradient, termed the MCT shear zone. Garnet-bearing rocks sampled from across the MCT along the Marysandi River in central Nepal contain monazite that decrease in age from Early Miocene (ca. 20 Ma) in the hanging wall to Late Miocene-Pliocene (ca. 7 Ma and 3 Ma) towards structurally lower levels in the shear zone. We obtained high-resolution garnet-zoning pressure-temperature (P-T) paths from 11 of the same rocks used for monazite geochronology using a recently-developed semi-automated Gibbs-free-energy-minimization technique. Quartz-in-garnet Raman barometry refined the locations of the paths. Diffusional re-equilibration of garnet zoning in hanging wall samples prevented accurate path determinations from most Greater Himalayan Crystalline samples, but one that shows a bell-shaped Mn zoning profile shows a slight decrease in P (from 8.2 to 7.6kbar) with increase in T (from 590 to 640ºC). Three MCT shear zone samples were modeled: one yields a simple path increasing in both P and T (6 to 7kbar, 540 to 580ºC); the others yield N-shaped paths that occupy similar P-T space (4 to 5.5 kbar, 500 to 560ºC). Five lower lesser Himalaya garnet-bearing rocks were modeled. One yields a path increasing in both P-T (6 to 7 kbar, 525 to 550ºC) but others show either sharp compression/decompression or N-shape paths (within 4.5-6 kbar and 530-580ºC). The lowermost sample decreases in P (5.5 to 5 kbar) over increasing T (540 to 580°C). No progressive change is seen from one type of path to another within the Lesser Himalayan Formations to the MCT zone. The results using the modeling approach yield lower P-T conditions compared to the Gibbs method and lower

T P Yadav

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. T P Yadav. Articles written in Bulletin of Materials Science. Volume 31 Issue 3 June 2008 pp 313-318. Investigation on carbon nanomaterials: Coaxial CNT-cylinders and CNT-polymer composite · Kalpana Awasthi T P Yadav P R Mishra S Awasthi O N Srivastava · More Details ...

T P Sharma

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. T P Sharma. Articles written in Bulletin of Materials Science. Volume 26 Issue 4 June 2003 pp 387-389 Magnetic Materials. Band gap determination of Ni–Zn ferrites · G P Joshi N S Saxena R Mangal A Mishra T P Sharma · More Details Abstract Fulltext PDF. Nanocomposites of ...

High Temperature Oxidation Behavior of T91 Steel in Dry and Humid Condition

Directory of Open Access Journals (Sweden)

Yonghao Leong

2016-09-01

Full Text Available High temperature oxidation behavior of T91 ferritic/martensitic steel was examined over the temperature range of 500 to 700°C in dry and humid environments.  The weight gain result revealed that oxidation occurs at all range of temperatures and its rate is accelerated by increasing the temperature. The weight gain of the oxidized steel at 700°C in steam condition was six times bigger than the dry oxidation.. SEM/EDX of the cross-sectional image showed that under dry condition, a protective and steady growth of the chromium oxide (Cr2O3 layer was formed on the steel with the thickness of 2.39±0.34 µm. Meanwhile for the humid environment, it is found that the iron oxide layer, which consists of the hematite (Fe2O3 and magnetite (Fe3O4 was formed as the outer scale, and spinnel as inner scale. This result indicated that the oxidation behavior of T91 steel was affected by its oxidation environment. The existence of water vapor in steam condition may prevent the formation of chromium oxide as protective layer.

Critical examination of RHIC paradigms - mostly high pT

International Nuclear Information System (INIS)

Tannenbaum, M.I.

2009-01-01

A critical examination of RHIC paradigms is presented. Topics include: search for a critical point with a low energy scan; the lack of understanding of radiative processes in a medium in QCD compared in detail to examples from QED; the reason why some physicists started to measure particles at large p T in the 1960's; a review of the discovery of hard-scattering in p-p collisions in the 1970's via single-inclusive and two-particle correlations and application of these techniques at RHIC. Several paradigms in both soft and hard physics which are popular at RHIC are discussed and challenged.

Extreme conditions (p, T, H)

Energy Technology Data Exchange (ETDEWEB)

Mesot, J [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)

1996-11-01

The aim of this paper is to summarize the sample environment which will be accessible at the SINQ. In order to illustrate the type of experiments which will be feasible under extreme conditions of temperature, magnetic field and pressure at the SINQ a few selected examples are also given. (author) 7 figs., 14 refs.

Inclusive photoproduction of single charged particles at high pT

International Nuclear Information System (INIS)

Apsimon, R.J.; Flower, P.S.; Hallewell, G.; Morris, J.A.G.; Morris, J.V.; Paterson, C.N.; Sharp, P.H.; Atkinson, M.; Brook, N.; Coyle, P.; Dickinson, B.; Donnachie, A.; Doyle, A.T.; Ellison, R.J.; Foster, J.M.; Hughes-Jones, R.E.; Ibbotson, M.; Kolya, S.D.; Lafferty, G.D.; McCann, H.; McManus, C.; Mercer, D.; Ottewell, P.J.; Reid, D.; Thompson, R.J.; Waterhouse, J.; Barberis, D.; Davenport, M.; Eades, J.; McClatchey, R.; Brodbeck, T.J.; Charity, T.; Clegg, A.B.; Henderson, R.C.W.; Hickman, M.T.; Keemer, N.R.; Newton, D.; O'Connor, A.; Wilson, G.W.; Danaher, S.; Galbraith, W.; Thacker, N.A.; Thompson, L.

1989-01-01

Single charged-particle inclusive cross sections for photon, pion and kaon beams on hydrogen at the CERN-SPS are presented as functions of p T and x F . Data cover the range 0.0 T F T < 1.6 GeV/c for the photon-induced data. Using the hadron-induced data to estimate the hadronic behaviour of the photon, the difference distributions and ratios of cross sections are a measure of the contribution of the point-like photon interactions. The data are compared with QCD calculations and show broadly similar features. (orig.)

Evidence from d+Au measurements for final-state suppression of high-p(T) hadrons in Au+Au collisions at RHIC.

Science.gov (United States)

Adams, J; Adler, C; Aggarwal, M M; Ahammed, Z; Amonett, J; Anderson, B D; Anderson, M; Arkhipkin, D; Averichev, G S; Badyal, S K; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bezverkhny, B I; Bhardwaj, S; Bhaskar, P; Bhati, A K; Bichsel, H; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Botje, M; Boucham, A; Brandin, A; Bravar, A; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca Sánchez, M; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; Das, D; Das, S; Derevschikov, A A; Didenko, L; Dietel, T; Dong, X; Draper, J E; Du, F; Dubey, A K; Dunin, V B; Dunlop, J C; Dutta Majumdar, M R; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Faivre, J; Fatemi, R; Filimonov, K; Filip, P; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Ganti, M S; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Ghosh, P; Gonzalez, J E; Grachov, O; Grigoriev, V; Gronstal, S; Grosnick, D; Guedon, M; Guertin, S M; Gupta, A; Gushin, E; Gutierrez, T D; Hallman, T J; Hardtke, D; Harris, J W; Heinz, M; Henry, T W; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Huang, S L; Humanic, T J; Igo, G; Ishihara, A; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E G; Kabana, S; Kaneta, M; Kaplan, M; Keane, D; Kiryluk, J; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Koetke, D D; Kollegger, T; Konstantinov, A S; Kopytine, M; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kumar, A; Kunde, G J; Kunz, C L; Kutuev, R Kh; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lauret, J; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, C; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Ludlam, T; Lynn, D; Ma, J; Ma, Y G; Magestro, D; Mahajan, S; Mangotra, L K; Mahapatra, D P; Majka, R; Manweiler, R; Margetis, S; Markert, C; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnick, Yu; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mironov, C; Mishra, D; Mitchell, J; Mohanty, B; Molnar, L; Moore, C F; Mora-Corral, M J; Morozov, V; de Moura, M M; Munhoz, M G; Nandi, B K; Nayak, S K; Nayak, T K; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Pal, S K; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Phatak, S C; Picha, R; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potekhin, M; Potrebenikova, E; Potukuchi, B V K S; Prindle, D; Pruneau, C; Putschke, J; Rai, G; Rakness, G; Raniwala, R; Raniwala, S; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Renault, G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Ruan, L J; Rykov, V; Sahoo, R; Sakrejda, I; Salur, S; Sandweiss, J; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schweda, K; Seger, J; Seliverstov, D; Seyboth, P; Shahaliev, E; Shao, M; Sharma, M; Shestermanov, K E; Shimanskii, S S; Singaraju, R N; Simon, F; Skoro, G; Smirnov, N; Snellings, R; Sood, G; Sorensen, P; Sowinski, J; Spinka, H M; Srivastava, B; Stanislaus, S; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A P; Sugarbaker, E; Suire, C; Sumbera, M; Surrow, B; Symons, T J M; Szanto de Toledo, A; Szarwas, P; Tai, A; Takahashi, J; Tang, A H; Thein, D; Thomas, J H; Tikhomirov, V; Tokarev, M; Tonjes, M B; Trainor, T A; Trentalange, S; Tribble, R E; Trivedi, M D; Trofimov, V; Tsai, O; Ullrich, T; Underwood, D G; Van Buren, G; VanderMolen, A M; Vasiliev, A N; Vasiliev, M; Vigdor, S E; Viyogi, Y P; Voloshin, S A; Waggoner, W; Wang, F; Wang, G; Wang, X L; Wang, Z M; Ward, H; Watson, J W; Wells, R; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Wood, J; Wu, J; Xu, N; Xu, Z; Xu, Z Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, H Y; Zhang, W M; Zhang, Z P; Zołnierczuk, P A; Zoulkarneev, R; Zoulkarneeva, J; Zubarev, A N

2003-08-15

We report measurements of single-particle inclusive spectra and two-particle azimuthal distributions of charged hadrons at high transverse momentum (high p(T)) in minimum bias and central d+Au collisions at sqrt[s(NN)]=200 GeV. The inclusive yield is enhanced in d+Au collisions relative to binary-scaled p+p collisions, while the two-particle azimuthal distributions are very similar to those observed in p+p collisions. These results demonstrate that the strong suppression of the inclusive yield and back-to-back correlations at high p(T) previously observed in central Au+Au collisions are due to final-state interactions with the dense medium generated in such collisions.

Under which conditions does T1 difficulty affect T2 performance in the attentional blink?

DEFF Research Database (Denmark)

Nielsen, Simon; Petersen, Anders; Andersen, Tobias Søren

2009-01-01

When two visual targets (T1 & T2) are presented in rapid succession, performance of T2 suffers up to 900 ms. One theory of this attentional blink (Raymond, Shapiro, & Arnell, 1992) propose that T1 and T2 compete for limited processing resources (Chun & Potter, 1995), and predict that prolonging...... processing time for T1 by increasing its perceptual difficulty will induce a larger blink. Several studies have tested this prediction without reaching a consistent answer. McLaughlin, Shore, & Klein (2001) found no effect of the exposure duration of T1 on the attentional blink. Christmann & Leuthold (2004...... duration. In the hard condition, T1 exposure duration was 10 ms while T1 contrast was adjusted individually to reach 50% correct T1 identification. In the long duration condition, T1 exposure duration was increased to reach approximately 90% correct T1 identification. In the high contrast condition, T1...

Study on Increasing High Temperature pH(t) to Reduce Iron Corrosion Products

International Nuclear Information System (INIS)

Shin, Dong Man; Hur, Nam Yong; Kim, Waang Bae

2011-01-01

The transportation and deposition of iron corrosion products are important elements that affect both the steam generator (SG) integrity and secondary system in pressurized water reactor (PWR) nuclear power plants. Most of iron corrosion products are generated on carbon steel materials due to flow accelerated corrosion (FAC). The several parameters like water chemistry, temperature, hydrodynamic, and steel composition affect FAC. It is well established that the at-temperature pH of the deaerated water system has a first order effect on the FAC rate of carbon steels through nuclear industry researches. In order to reduce transportation and deposition of iron corrosion products, increasing pH(t) tests were applied on secondary system of A, B units. Increasing pH(t) successfully reduced flow accelerated corrosion. The effect of increasing pH(t) to inhibit FAC was identified through the experiment and pH(t) evaluation in this paper

Transverse-momentum and collision-energy dependence of high-pT hadron suppression in Au+Au collisions at ultrarelativistic energies.

Science.gov (United States)

Adams, J; Adler, C; Aggarwal, M M; Ahammed, Z; Amonett, J; Anderson, B D; Anderson, M; Arkhipkin, D; Averichev, G S; Badyal, S K; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bezverkhny, B I; Bhardwaj, S; Bhaskar, P; Bhati, A K; Bichsel, H; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Botje, M; Boucham, A; Brandin, A; Bravar, A; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca Sánchez, M; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; Das, D; Das, S; Derevschikov, A A; Didenko, L; Dietel, T; Dong, X; Draper, J E; Drees, K A; Du, F; Dubey, A K; Dunin, V B; Dunlop, J C; Dutta Majumdar, M R; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Faivre, J; Fatemi, R; Filimonov, K; Filip, P; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Ganti, M S; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Ghosh, P; Gonzalez, J E; Grachov, O; Grigoriev, V; Gronstal, S; Grosnick, D; Guedon, M; Guertin, S M; Gupta, A; Gushin, E; Gutierrez, T D; Hallman, T J; Hardtke, D; Harris, J W; Heinz, M; Henry, T W; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Huang, S L; Humanic, T J; Igo, G; Ishihara, A; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E G; Kabana, S; Kaneta, M; Kaplan, M; Keane, D; Kiryluk, J; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Kollegger, T; Konstantinov, A S; Kopytine, M; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kumar, A; Kunde, G J; Kunz, C L; Kutuev, R Kh; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lauret, J; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, C; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Ludlam, T; Lynn, D; Ma, J; Ma, Y G; Magestro, D; Mahajan, S; Mangotra, L K; Mahapatra, D P; Majka, R; Manweiler, R; Margetis, S; Markert, C; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnick, Yu; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mironov, C; Mishra, D; Mitchell, J; Mohanty, B; Molnar, L; Moore, C F; Mora-Corral, M J; Morozov, V; de Moura, M M; Munhoz, M G; Nandi, B K; Nayak, S K; Nayak, T K; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Pal, S K; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Phatak, S C; Picha, R; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potekhin, M; Potrebenikova, E; Potukuchi, B V K S; Prindle, D; Pruneau, C; Putschke, J; Rai, G; Rakness, G; Raniwala, R; Raniwala, S; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Renault, G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Ruan, L J; Rykov, V; Sahoo, R; Sakrejda, I; Salur, S; Sandweiss, J; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schweda, K; Seger, J; Seliverstov, D; Seyboth, P; Shahaliev, E; Shao, M; Sharma, M; Shestermanov, K E; Shimanskii, S S; Singaraju, R N; Simon, F; Skoro, G; Smirnov, N; Snellings, R; Sood, G; Sorensen, P; Sowinski, J; Spinka, H M; Srivastava, B; Stanislaus, S; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A P; Sugarbaker, E; Suire, C; Sumbera, M; Surrow, B; Symons, T J M; Szanto de Toledo, A; Szarwas, P; Tai, A; Takahashi, J; Tang, A H; Thein, D; Thomas, J H; Tikhomirov, V; Tokarev, M; Tonjes, M B; Trainor, T A; Trentalange, S; Tribble, R E; Trivedi, M D; Trofimov, V; Tsai, O; Ullrich, T; Underwood, D G; Van Buren, G; VanderMolen, A M; Vasiliev, A N; Vasiliev, M; Vigdor, S E; Viyogi, Y P; Voloshin, S A; Waggoner, W; Wang, F; Wang, G; Wang, X L; Wang, Z M; Ward, H; Watson, J W; Wells, R; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Wood, J; Wu, J; Xu, N; Xu, Z; Xu, Z Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, H Y; Zhang, W M; Zhang, Z P; Zołnierczuk, P A; Zoulkarneev, R; Zoulkarneeva, J; Zubarev, A N

2003-10-24

We report high statistics measurements of inclusive charged hadron production in Au+Au and p+p collisions at sqrt[s(NN)]=200 GeV. A large, approximately constant hadron suppression is observed in central Au+Au collisions for 5<p(T)<12 GeV/c. The collision energy dependence of the yields and the centrality and p(T) dependence of the suppression provide stringent constraints on theoretical models of suppression. Models incorporating initial-state gluon saturation or partonic energy loss in dense matter are largely consistent with observations. We observe no evidence of p(T)-dependent suppression, which may be expected from models incorporating jet attenuation in cold nuclear matter or scattering of fragmentation hadrons.

Under which conditions does T1 difficulty affect T2 performance in the attentional blink?

DEFF Research Database (Denmark)

Nielsen, Simon; Petersen, Anders; Andersen, Tobias

When two visual targets (T1 & T2) are presented in rapid succession, performance of T2 suffers up to 900 ms. One theory of this attentional blink (Raymond, Shapiro, & Arnell, 1992) propose that T1 and T2 compete for limited processing resources (Chun & Potter, 1995), and predict that prolonging...... processing time for T1 by increasing its perceptual difficulty will induce a larger blink. Several studies have tested this prediction without reaching a consistent answer. McLaughlin, Shore, & Klein (2001) found no effect of the exposure duration of T1 on the attentional blink. Christmann & Leuthold (2004...... duration. In the hard condition, T1 exposure duration was 10 ms while T1 contrast was adjusted individually to reach 50% correct T1 identification. In the long duration condition, T1 exposure duration was increased to reach approximately 90% correct T1 identification. In the high contrast condition, T1...

Development of backward equations T(p,h), T(p,s) and p(h,s) for heavy water liquid and vapor

International Nuclear Information System (INIS)

Nick P Petropoulos; Simos E Simopoulos

2005-01-01

Full text of publication follows: Backward equations for heavy water (a) temperature as a function of pressure and enthalpy T(p,h), (b) temperature as a function of pressure and entropy T(p,s) and (c) pressure as a function of enthalpy and entropy p(h,s) presented in this work, are based on the 'IAPS Formulation 1984 for the Thermodynamic Properties of Heavy Water Substance' [1], and also on the respective equations for the ordinary water substance as presented in 'The IAPWS Industrial Formulation 1997 for the Thermodynamic Properties of Water and Steam' [2]. Heavy water and steam thermodynamic properties can be calculated using the basic equations and saturation equations that are included in [1]. However, [1] does not contain any backward functions T(p,h), T(p,s) and p(h,s), which are needed for heavy water thermodynamic process modeling. The development of the two temperature backward functions efficiently increases computational speed for temperature calculations more than three times as pointed out in the similar case problem for ordinary water, addressed successfully in [2]. Without these temperature backward functions calculations may be performed only iteratively using the heavy water state equations at a much greater computing cost. Moreover, the development of the pressure backward function saves even more computing time in modeling problems since two-dimensional iterations from the h(p,T) and s(p,T) heavy water functions may by effectively avoided. In addition, given the pressure function p(h,s), the heavy water temperature T(h,s) can be calculated by the temperature function T(p,h). The numerical consistencies of calculated T and p to the state equations included in [1] are sufficient for most applications in the heavy water nuclear reactors heat cycles. For applications, where the demands on numerical consistency and accuracy are rather high, iterations with the approved state equations may be necessary. In these cases both temperature and pressure

New superhindered polydentate polyphosphine ligands P(CH2CH2P(t)Bu2)3, PhP(CH2CH2P(t)Bu2)2, P(CH2CH2CH2P(t)Bu2)3, and their ruthenium(II) chloride complexes.

Science.gov (United States)

Gilbert-Wilson, Ryan; Field, Leslie D; Bhadbhade, Mohan M

2012-03-05

The synthesis and characterization of the extremely hindered phosphine ligands, P(CH(2)CH(2)P(t)Bu(2))(3) (P(2)P(3)(tBu), 1), PhP(CH(2)CH(2)P(t)Bu(2))(2) (PhP(2)P(2)(tBu), 2), and P(CH(2)CH(2)CH(2)P(t)Bu(2))(3) (P(3)P(3)(tBu), 3) are reported, along with the synthesis and characterization of ruthenium chloro complexes RuCl(2)(P(2)P(3)(tBu)) (4), RuCl(2)(PhP(2)P(2)(tBu)) (5), and RuCl(2)(P(3)P(3)(tBu)) (6). The bulky P(2)P(3)(tBu) (1) and P(3)P(3)(tBu) (3) ligands are the most sterically encumbered PP(3)-type ligands so far synthesized, and in all cases, only three phosphorus donors are able to bind to the metal center. Complexes RuCl(2)(PhP(2)P(2)(tBu)) (5) and RuCl(2)(P(3)P(3)(tBu)) (6) were characterized by crystallography. Low temperature solution and solid state (31)P{(1)H} NMR were used to demonstrate that the structure of RuCl(2)(P(2)P(3)(tBu)) (4) is probably analogous to that of RuCl(2)(PhP(2)P(2)(tBu)) (5) which had been structurally characterized.

Angular dependence of high-p/sub T/ pi /sup 0/ production

CERN Document Server

Lloyd-Owen, D; Bellettini, G; Braccini, Pier Luigi; Castaldi, R; Cavasinni, V; Del Prete, T; Finocchiaro, G; Grannis, P D; Jöstlein, H; Kephart, R D; Laurelli, P; Sanguinetti, G; Thun, R; Valdata-Nappi, M

1981-01-01

The authors have measured inclusive pi /sup 0/ production cross- sections at the CERN ISR for p/sub T/ <5 GeV/c at c.m. angles of theta =90 degrees and 5< theta <22 degrees at c.m. energies square root s=23 and 53 GeV. The data are in agreement with previous measurements of pi degrees production at FNAL and the ISR. The authors have compared these data with the hypothesis of radial scaling, which asserts that the inclusive cross section should be a function of x/sub R/ and p/sub T/ alone. Here x/sub R/ is the fraction of available energy carried by the produced particle. They find that radial scaling is not satisfactory over the energy and angle range of this experiment. Comparing their data with radial scaling fits to mainly FNAL data, the authors find that their cross sections approach ten times the prediction at large p/sub T/ and x/sub R/. As a more direct test of the hypothesis, the authors compare their data for which x/sub R/ variation occurs as theta varies at fixed s, with that from ISR expe...

A quasi-model-independent search for new high p_T physics at D0

Energy Technology Data Exchange (ETDEWEB)

Knuteson, Bruce Owen [Univ. of California, Berkeley, CA (United States)

2000-12-05

We present a new quasi-model-independent strategy (''Sleuth'') for searching for physics beyond the standard model. We define final states to be studied, and construct a rule that identifies a set of relevant variables for any particular final state. A novel algorithm searches for regions of excess in those variables and quantifies the significance of any detected excess. This strategy is applied to search for new high p_T physics in approximately 100 pb^-1 of proton-anti-proton collisions a √s = 1.8 TeV collected by the D0 experiment during 1992-1996 at the Fermilab Tevatron. We systematically analyze many exclusive final states, and demonstrate sensitivity to a variety of models predicting new phenomena at the electroweak scale. No evidence of new high p_T physics is observed.

Measurement of the integrated and differential $\\mathrm{t \\bar{t}}$ production cross sections for high-$p_{\\mathrm{T}}$ top quarks in pp collisions at $ \\sqrt{s} = $ 8 TeV

CERN Document Server

Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Knutsson, Albert; Lauwers, Jasper; Luyckx, Sten; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Keaveney, James; 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Sacchi, Roberto; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Belforte, Stefano; Candelise, Vieri; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; La Licata, Chiara; Schizzi, Andrea; Zanetti, Anna; Nam, Soon-Kwon; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Kong, Dae Jung; Lee, Sangeun; Lee, Seh Wook; Oh, Young Do; Sakharov, Alexandre; Son, Dong-Chul; Brochero Cifuentes, Javier Andres; Kim, Hyunsoo; Kim, Tae Jeong; Song, Sanghyeon; Cho, Sungwoong; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Hong, Byung-Sik; Kim, Yongsun; Lee, Byounghoon; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Lim, Jaehoon; Park, Sung Keun; Roh, Youn; Yoo, Hwi Dong; Choi, Minkyoo; Kim, Hyunchul; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Goh, Junghwan; Kim, Donghyun; Kwon, Eunhyang; Lee, Jongseok; Yu, Intae; Dudenas, Vytautas; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Zolkapli, Zukhaimira; Casimiro Linares, Edgar; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Mejia Guisao, Jhovanny; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Vazquez Valencia, Fabiola; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Khurshid, Taimoor; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Traczyk, Piotr; Zalewski, Piotr; Brona, Grzegorz; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Nguyen, Federico; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; Bunin, Pavel; Golutvin, Igor; Kamenev, Alexey; Karjavin, Vladimir; Korenkov, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Mitsyn, Valeri Valentinovitch; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Tikhonenko, Elena; Voytishin, Nikolay; Zarubin, Anatoli; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Levchenko, Petr; Murzin, Victor; Oreshkin, Vadim; Smirnov, Igor; Sulimov, Valentin; Uvarov, Lev; Vavilov, Sergey; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Chadeeva, Marina; Chistov, Ruslan; Danilov, Mikhail; Rusinov, Vladimir; Tarkovskii, Evgenii; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Mesyats, Gennady; Rusakov, Sergey V; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Bunichev, Viacheslav; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Klyukhin, Vyacheslav; Korneeva, Natalia; Lokhtin, Igor; Miagkov, Igor; Obraztsov, Stepan; Perfilov, Maxim; Petrushanko, Sergey; Savrin, Viktor; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Tourtchanovitch, Leonid; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Cirkovic, Predrag; Devetak, Damir; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Senghi Soares, Mara; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Folgueras, Santiago; Gonzalez Caballero, Isidro; Palencia Cortezon, Enrique; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Castiñeiras De Saa, Juan Ramon; Curras, Esteban; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Marco, Rafael; Martinez Rivero, Celso; Matorras, Francisco; Piedra Gomez, Jonatan; Rodrigo, Teresa; Rodríguez-Marrero, Ana Yaiza; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Trevisani, Nicolò; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Benaglia, Andrea; Benhabib, Lamia; Berruti, Gaia Maria; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Botta, Cristina; Breuker, Horst; Camporesi, Tiziano; Castello, Roberto; Cepeda, Maria; Cerminara, Gianluca; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Guio, Federico; De Roeck, Albert; Di Marco, Emanuele; Dobson, Marc; Dordevic, Milos; Dorney, Brian; Du Pree, Tristan; Duggan, Daniel; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Fartoukh, Stephane; Franzoni, Giovanni; Fulcher, Jonathan; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Girone, Maria; Glege, Frank; Guida, Roberto; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kirschenmann, Henning; Knünz, Valentin; Kortelainen, Matti J; Kousouris, Konstantinos; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Magini, Nicolo; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Masetti, Lorenzo; Meijers, Frans; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Piparo, Danilo; Racz, Attila; Reis, Thomas; Rolandi, Gigi; Rovere, Marco; Ruan, Manqi; Sakulin, Hannes; Sauvan, Jean-Baptiste; Schäfer, Christoph; Schwick, Christoph; Seidel, Markus; Sharma, Archana; Silva, Pedro; Simon, Michal; Sphicas, Paraskevas; Steggemann, Jan; Stoye, Markus; Takahashi, Yuta; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veckalns, Viesturs; Veres, Gabor Istvan; Wardle, Nicholas; Wöhri, Hermine Katharina; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Rohe, Tilman; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Casal, Bruno; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Eller, Philipp; Grab, Christoph; Heidegger, Constantin; Hits, Dmitry; Hoss, Jan; Kasieczka, Gregor; Lecomte, Pierre; Lustermann, Werner; Mangano, Boris; Marionneau, Matthieu; Martinez Ruiz del Arbol, Pablo; Masciovecchio, Mario; Meinhard, Maren Tabea; Meister, Daniel; Micheli, Francesco; Musella, Pasquale; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pata, Joosep; Pauss, Felicitas; Perrin, Gaël; Perrozzi, Luca; Quittnat, Milena; Rossini, Marco; Schönenberger, Myriam; Starodumov, Andrei; Takahashi, Maiko; Tavolaro, Vittorio Raoul; Theofilatos, Konstantinos; Wallny, Rainer; Aarrestad, Thea Klaeboe; Amsler, Claude; Caminada, Lea; Canelli, Maria Florencia; Chiochia, Vincenzo; De Cosa, Annapaola; Galloni, Camilla; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Lange, Clemens; Ngadiuba, Jennifer; Pinna, Deborah; Rauco, Giorgia; Robmann, Peter; Salerno, Daniel; Yang, Yong; Chen, Kuan-Hsin; Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Pozdnyakov, Andrey; Yu, Shin-Shan; Kumar, Arun; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Fiori, Francesco; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Tsai, Jui-fa; Tzeng, Yeng-Ming; Asavapibhop, Burin; Kovitanggoon, Kittikul; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Adiguzel, Aytul; Cerci, Salim; Damarseckin, Serdal; Demiroglu, Zuhal Seyma; Dozen, Candan; Dumanoglu, Isa; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kayis Topaksu, Aysel; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Tali, Bayram; Topakli, Huseyin; Zorbilmez, Caglar; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; Gülmez, Erhan; Kaya, Mithat; Kaya, Ozlem; Yetkin, Elif Asli; Yetkin, Taylan; Cakir, Altan; Cankocak, Kerem; Sen, Sercan; Vardarlı, Fuat Ilkehan; Grynyov, Boris; Levchuk, Leonid; Sorokin, Pavel; Aggleton, Robin; Ball, Fionn; Beck, Lana; Brooke, James John; Burns, Douglas; Clement, Emyr; Cussans, David; Flacher, Henning; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Meng, Zhaoxia; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Sakuma, Tai; Seif El Nasr-storey, Sarah; Senkin, Sergey; Smith, Dominic; Smith, Vincent J; Bell, Ken W; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Calligaris, Luigi; Cieri, Davide; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Tomalin, Ian R; Williams, Thomas; Worm, Steven; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Bundock, Aaron; Burton, Darren; Casasso, Stefano; Citron, Matthew; Colling, David; Corpe, Louie; Dauncey, Paul; Davies, Gavin; De Wit, Adinda; Della Negra, Michel; Dunne, Patrick; Elwood, Adam; Futyan, David; Haddad, Yacine; Hall, Geoffrey; Iles, Gregory; Lane, Rebecca; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Mastrolorenzo, Luca; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Penning, Bjoern; Pesaresi, Mark; Raymond, David Mark; Richards, Alexander; Rose, Andrew; Seez, Christopher; Tapper, Alexander; Uchida, Kirika; Vazquez Acosta, Monica; Virdee, Tejinder; Zenz, Seth Conrad; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leslie, Dawn; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Borzou, Ahmad; Call, Kenneth; Dittmann, Jay; Hatakeyama, Kenichi; Liu, Hongxuan; Pastika, Nathaniel; Charaf, Otman; Cooper, Seth; Henderson, Conor; Rumerio, Paolo; Arcaro, Daniel; Avetisyan, Aram; Bose, Tulika; Gastler, Daniel; Rankin, Dylan; Richardson, Clint; Rohlf, James; Sulak, Lawrence; Zou, David; Alimena, Juliette; Benelli, Gabriele; Berry, Edmund; Cutts, David; Ferapontov, Alexey; Garabedian, Alex; Hakala, John; Heintz, Ulrich; Jesus, Orduna; Laird, Edward; Landsberg, Greg; Mao, Zaixing; Narain, Meenakshi; Piperov, Stefan; Sagir, Sinan; Syarif, Rizki; Breedon, Richard; Breto, Guillermo; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Funk, Garrett; Gardner, Michael; Ko, Winston; Lander, Richard; Mclean, Christine; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Ricci-Tam, Francesca; Shalhout, Shalhout; Smith, John; Squires, Michael; Stolp, Dustin; Tripathi, Mani; Wilbur, Scott; Yohay, Rachel; Cousins, Robert; Everaerts, Pieter; Florent, Alice; Hauser, Jay; Ignatenko, Mikhail; Saltzberg, David; Takasugi, Eric; Valuev, Vyacheslav; Weber, Matthias; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Hanson, Gail; Heilman, Jesse; Paneva, Mirena Ivova; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Long, Owen Rosser; Malberti, Martina; Olmedo Negrete, Manuel; Shrinivas, Amithabh; Wei, Hua; Wimpenny, Stephen; Yates, Brent; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; D'Agnolo, Raffaele Tito; Derdzinski, Mark; Gerosa, Raffaele; Holzner, André; Kelley, Ryan; Klein, Daniel; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Wood, John; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Incandela, Joe; Mccoll, Nickolas; Mullin, Sam Daniel; Richman, Jeffrey; Stuart, David; Suarez, Indara; West, Christopher; Yoo, Jaehyeok; Anderson, Dustin; Apresyan, Artur; Bendavid, Joshua; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Duarte, Javier; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Spiropulu, Maria; Vlimant, Jean-Roch; Xie, Si; Zhu, Ren-Yuan; Andrews, Michael Benjamin; Azzolini, Virginia; Calamba, Aristotle; Carlson, Benjamin; Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Ford, William T; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Mulholland, Troy; Nauenberg, Uriel; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chatterjee, Avishek; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Eggert, Nicholas; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Sun, Werner; Tan, Shao Min; Teo, Wee Don; Thom, Julia; Thompson, Joshua; Tucker, Jordan; Weng, Yao; Wittich, Peter; Abdullin, Salavat; Albrow, Michael; Apollinari, Giorgio; Banerjee, Sunanda; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hanlon, Jim; Hare, Daryl; Harris, Robert M; Hasegawa, Satoshi; Hirschauer, James; Hu, Zhen; Jayatilaka, Bodhitha; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Klima, Boaz; Kreis, Benjamin; Lammel, Stephan; Lewis, Jonathan; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Tiehui; Lopes De Sá, Rafael; Lykken, Joseph; Maeshima, Kaori; Marraffino, John Michael; Maruyama, Sho; Mason, David; McBride, Patricia; Merkel, Petra; Mrenna, Stephen; Nahn, Steve; Newman-Holmes, Catherine; O'Dell, Vivian; Pedro, Kevin; Prokofyev, Oleg; Rakness, Gregory; Sexton-Kennedy, Elizabeth; Soha, Aron; Spalding, William J; Spiegel, Leonard; Stoynev, Stoyan; Strobbe, Nadja; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vernieri, Caterina; Verzocchi, Marco; Vidal, Richard; Wang, Michael; Weber, Hannsjoerg Artur; Whitbeck, Andrew; Acosta, Darin; Avery, Paul; Bortignon, Pierluigi; Bourilkov, Dimitri; Brinkerhoff, Andrew; Carnes, Andrew; Carver, Matthew; Curry, David; Das, Souvik; Field, Richard D; Furic, Ivan-Kresimir; Konigsberg, Jacobo; Korytov, Andrey; Kotov, Khristian; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Milenovic, Predrag; Mitselmakher, Guenakh; Rank, Douglas; Rossin, Roberto; Shchutska, Lesya; Sperka, David; Terentyev, Nikolay; Thomas, Laurent; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Jordon Rowe; Adams, Todd; Askew, Andrew; Bein, Samuel; Bochenek, Joseph; Diamond, Brendan; Haas, Jeff; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Khatiwada, Ajeeta; Prosper, Harrison; Santra, Arka; Weinberg, Marc; Baarmand, Marc M; Bhopatkar, Vallary; Colafranceschi, Stefano; Hohlmann, Marcus; Kalakhety, Himali; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Kurt, Pelin; O'Brien, Christine; Sandoval Gonzalez, Irving Daniel; Turner, Paul; Varelas, Nikos; Wu, Zhenbin; Zakaria, Mohammed; Zhang, Jingyu; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tiras, Emrah; Wetzel, James; Yi, Kai; Anderson, Ian; Blumenfeld, Barry; Cocoros, Alice; Eminizer, Nicholas; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Osherson, Marc; Roskes, Jeffrey; Sarica, Ulascan; Swartz, Morris; Xiao, Meng; Xin, Yongjie; You, Can; Baringer, Philip; Bean, Alice; Bruner, Christopher; Castle, James; Kenny III, Raymond Patrick; Kropivnitskaya, Anna; Majumder, Devdatta; Malek, Magdalena; Mcbrayer, William; Murray, Michael; Sanders, Stephen; Stringer, Robert; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Khalil, Sadia; Makouski, Mikhail; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Lange, David; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Gomez, Jaime; Hadley, Nicholas John; Jabeen, Shabnam; Kellogg, Richard G; Kolberg, Ted; Kunkle, Joshua; Lu, Ying; Mignerey, Alice; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Apyan, Aram; Barbieri, Richard; Baty, Austin; Bi, Ran; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; Demiragli, Zeynep; Di Matteo, Leonardo; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Gulhan, Doga; Hsu, Dylan; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Krajczar, Krisztian; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Narayanan, Siddharth; Niu, Xinmei; Paus, Christoph; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Sumorok, Konstanty; Tatar, Kaya; Varma, Mukund; Velicanu, Dragos; Veverka, Jan; Wang, Jing; Wang, Ta-Wei; Wyslouch, Bolek; Yang, Mingming; Zhukova, Victoria; Benvenuti, Alberto; Dahmes, Bryan; Evans, Andrew; Finkel, Alexey; Gude, Alexander; Hansen, Peter; Kalafut, Sean; Kao, Shih-Chuan; Klapoetke, Kevin; Kubota, Yuichi; Lesko, Zachary; Mans, Jeremy; Nourbakhsh, Shervin; Ruckstuhl, Nicole; Rusack, Roger; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bartek, Rachel; Bloom, Kenneth; Bose, Suvadeep; Claes, Daniel R; Dominguez, Aaron; Fangmeier, Caleb; Gonzalez Suarez, Rebeca; Kamalieddin, Rami; Knowlton, Dan; Kravchenko, Ilya; Meier, Frank; Monroy, Jose; Ratnikov, Fedor; Siado, Joaquin Emilo; Snow, Gregory R; Stieger, Benjamin; Alyari, Maral; Dolen, James; George, Jimin; Godshalk, Andrew; Harrington, Charles; Iashvili, Ia; Kaisen, Josh; Kharchilava, Avto; Kumar, Ashish; Parker, Ashley; Rappoccio, Salvatore; Roozbahani, Bahareh; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Chasco, Matthew; Hortiangtham, Apichart; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Teixeira De Lima, Rafael; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Zhang, Jinzhong; Bhattacharya, Saptaparna; Hahn, Kristan Allan; Kubik, Andrew; Low, Jia Fu; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Schmitt, Michael Henry; Sung, Kevin; Trovato, Marco; Velasco, Mayda; Dev, Nabarun; Hildreth, Michael; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Marinelli, Nancy; Meng, Fanbo; Mueller, Charles; Musienko, Yuri; Planer, Michael; Reinsvold, Allison; Ruchti, Randy; Rupprecht, Nathaniel; Smith, Geoffrey; Taroni, Silvia; Valls, Nil; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Antonelli, Louis; Brinson, Jessica; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Hart, Andrew; Hill, Christopher; Hughes, Richard; Ji, Weifeng; Ling, Ta-Yung; Liu, Bingxuan; Luo, Wuming; Puigh, Darren; Rodenburg, Marissa; Winer, Brian L; Wulsin, Howard Wells; Driga, Olga; Elmer, Peter; Hardenbrook, Joshua; Hebda, Philip; Koay, Sue Ann; Lujan, Paul; Marlow, Daniel; Medvedeva, Tatiana; Mooney, Michael; Olsen, James; Palmer, Christopher; Piroué, Pierre; Stickland, David; Tully, Christopher; Zuranski, Andrzej; Malik, Sudhir; Barker, Anthony; Barnes, Virgil E; Benedetti, Daniele; Gutay, Laszlo; Jha, Manoj; Jones, Matthew; Jung, Andreas Werner; Jung, Kurt; Miller, David Harry; Neumeister, Norbert; Radburn-Smith, Benjamin Charles; Shi, Xin; Sun, Jian; Svyatkovskiy, Alexey; Wang, Fuqiang; Xie, Wei; Xu, Lingshan; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Chen, Zhenyu; Ecklund, Karl Matthew; Geurts, Frank JM; Guilbaud, Maxime; Li, Wei; Michlin, Benjamin; Northup, Michael; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Rorie, Jamal; Tu, Zhoudunming; Zabel, James; Betchart, Burton; Bodek, Arie; de Barbaro, Pawel; Demina, Regina; Duh, Yi-ting; Eshaq, Yossof; Ferbel, Thomas; Galanti, Mario; Garcia-Bellido, Aran; Han, Jiyeon; Hindrichs, Otto; Khukhunaishvili, Aleko; Lo, Kin Ho; Tan, Ping; Verzetti, Mauro; Chou, John Paul; Contreras-Campana, Emmanuel; Gershtein, Yuri; Gómez Espinosa, Tirso Alejandro; Halkiadakis, Eva; Heindl, Maximilian; Hidas, Dean; Hughes, Elliot; Kaplan, Steven; Kunnawalkam Elayavalli, Raghav; Kyriacou, Savvas; Lath, Amitabh; Nash, Kevin; Saka, Halil; Salur, Sevil; Schnetzer, Steve; Sheffield, David; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Foerster, Mark; Heideman, Joseph; Riley, Grant; Rose, Keith; Spanier, Stefan; Thapa, Krishna; Bouhali, Othmane; Castaneda Hernandez, Alfredo; Celik, Ali; Dalchenko, Mykhailo; De Mattia, Marco; Delgado, Andrea; Dildick, Sven; Eusebi, Ricardo; Gilmore, Jason; Huang, Tao; Kamon, Teruki; Krutelyov, Vyacheslav; Mueller, Ryan; Osipenkov, Ilya; Pakhotin, Yuriy; Patel, Rishi; Perloff, Alexx; Perniè, Luca; Rathjens, Denis; Rose, Anthony; Safonov, Alexei; Tatarinov, Aysen; Ulmer, Keith; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Kunori, Shuichi; Lamichhane, Kamal; Lee, Sung Won; Libeiro, Terence; Undleeb, Sonaina; Volobouev, Igor; Wang, Zhixing; Appelt, Eric; Delannoy, Andrés G; Greene, Senta; Gurrola, Alfredo; Janjam, Ravi; Johns, Willard; Maguire, Charles; Mao, Yaxian; Melo, Andrew; Ni, Hong; Sheldon, Paul; Tuo, Shengquan; Velkovska, Julia; Xu, Qiao; Arenton, Michael Wayne; Barria, Patrizia; Cox, Bradley; Francis, Brian; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Neu, Christopher; Sinthuprasith, Tutanon; Sun, Xin; Wang, Yanchu; Wolfe, Evan; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Kottachchi Kankanamge Don, Chamath; Lamichhane, Pramod; Sturdy, Jared; Belknap, Donald; Carlsmith, Duncan; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Gomber, Bhawna; Grothe, Monika; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Mohapatra, Ajit; Ojalvo, Isabel; Perry, Thomas; Pierro, Giuseppe Antonio; Polese, Giovanni; Ruggles, Tyler; Sarangi, Tapas; Savin, Alexander; Sharma, Archana; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Verwilligen, Piet; Woods, Nathaniel

2016-10-12

The cross section for pair production of top quarks ($\\mathrm{ t \\bar{t} }$) with high transverse momenta is measured in $\\mathrm{ p } \\mathrm{ p }$ collisions, collected with the CMS detector at the LHC with $ \\sqrt{s} = $ 8 TeV in data corresponding to an integrated luminosity of 19.7 fb$^{-1}$. The measurement is performed using lepton+jets events, where one top quark decays semileptonically, while the second top quark decays to a hadronic final state. The hadronic decay is reconstructed as a single, large-radius jet, and identified as a top quark candidate using jet substructure techniques. The integrated cross section and the differential cross sections as a function of top quark $p_{\\mathrm{T}}$ and rapidity are measured at particle level within a fiducial region related to the detector-level requirements and at parton level. The particle-level integrated cross section is found to be $\\sigma_{\\mathrm{ t \\bar{t} }} =$ 0.499 $\\pm$ 0.035 (stat+syst) $\\pm$ 0.095 (theory) $\\pm$ 0.013 (lumi) pb for top quark...

Spin dependence in high $p^{2}_{T}$ elastic pp and np scattering

CERN Document Server

Crabb, D G; Hansen, P.H.; Hauser, J.; Krisch, A.D.; Sandler, B.; Shima, T.; Terwilliger, K.M.; Crosbie, E.A.; Ratner, L.G.; Schultz, P.F.; Thomas, G.H.; O'Fallon, J.R.; Lin, A.D.; Salthouse, A.J.; Linn, S.L.; Perlmutter, A.; Karmakar, N.L.; Kyberd, P.

1979-01-01

Using the polarized proton capability of the Argonne ZGS the authors recently made 90 degrees /sub cm/ measurements of elastic pp scattering from 6 to 11.75 GeV/c, determining the parallel and anti- parallel pure initial spin state cross sections and the associated spin-spin parameter A/sub nn/ with the spins normal to the scattering plane. They find that the parallel to anti-parallel cross section ratio rises dramatically from 1.2+or-.06 at p/sub t//sup 2/=3.3 (GeV /c)/sup 2/ to 3.2+or-.4 at 4.8 (GeV/c)/sup 2/, similar to the p/sub T //sup 2/ dependence previously observed at the fixed laboratory momentum of 11.75 GeV/c. They have also extended the measurements at 6 GeV/c and find that A/sub nn/ has a small but sharp rise at 90 degrees /sub cm/. In addition a month of 12 GeV/c polarized deuteron acceleration in the ZGS enabled them to measure two A/sub nn/ at two points at 6 GeV/c for np elastic scattering: A/sub nn/=-.17+or-.04 at p/sub T//sup 2/=.8, A/sub nn/=-.19+or-.05 at P/sub T//sup 2/=1.0. These value...

T P Nafeesa Baby

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. T P Nafeesa Baby. Articles written in Pramana – Journal of Physics. Volume 80 Issue 2 February 2013 pp 289-294 Research Articles. Plasma excitations in a single-walled carbon nanotube with an external transverse magnetic field · K A Vijayalakshmi T P Nafeesa Baby.

Identified particle yield associated with a high-$p_T$ trigger particle at the LHC

CERN Document Server

Veldhoen, Misha; van Leeuwen, Marco

Identified particle production ratios are important observables, used to constrain models of particle production in heavy-ion collisions. Measurements of the inclusive particle ratio in central heavy-ion collisions showed an increase of the baryon-to-meson ratio compared to proton-proton collisions at intermediate pT, the so-called baryon anomaly. One possible explanation of the baryon anomaly is that partons from the thermalized deconfined QCD matter hadronize in a different way compared to hadrons produced in a vacuum jet. In this work we extend on previous measurements by measuring particle ratios in the yield associated with a high-pT trigger particle. These measurements can potentially further constrain the models of particle production since they are sensitive to the difference between particles from a jet and particles that are produced in the bulk. We start by developing a particle identification method that uses both the specific energy loss of a particle and the time of flight. From there, we presen...

The sensitivity of particle pH to NH3: Can high NH3 cause London Fog conditions?

Science.gov (United States)

Weber, R. J.; Guo, H.; Nenes, A.

2017-12-01

High ammonia emissions from agriculture or other sources have been suggested to elevate ambient particle pH levels to near neutral acidity (pH=7), a condition that promotes rapid SO2 oxidation by NO2 to form aerosol sulfate concentration consistent with "London fog" levels. This mechanism has been used to explain pollution haze events in China. Predicted pH for locations in the US and Europe show fine particles are highly acidic with pH typically less than 2. The results are consistent with measured ammonia and nitric acid gas-particle partitioning, validating predicted pH levels. Using these data sets from representative sites around the world we conduct a thermodynamic analysis of aerosol pH and its sensitivity to ammonia levels. We find that particle pH, regardless of ammonia levels, is always acidic even for the unusually high ammonia levels found in highly polluted Asian cities, Beijing (pH=4.5) and Xi'an (pH=5), locations where sulfate production from NOx is proposed. These results indicate that sulfur dioxide oxidation through a NO2-mediated pathway is not likely in China, nor any other region of the world (e.g., US, Mediterranean) since the fine aerosol is consistently acidic. The mildly acidic conditions would, however, permit rapid oxidation of sulfur dioxide through transition metal chemistry. The limited alkalinity from the carbonate buffer in dust and seasalt can provide the only likely set of conditions where NO2-mediated oxidation of SO2 outcompetes with other well-established pathways.

Analysis of high signal intensities of nontumorous conditions of corpus callosum on magnetic resonance T2-weighted images

International Nuclear Information System (INIS)

Kang, Moo Song; Kim, Chul Min; Chung, Chun Phil

1995-01-01

To evaluate high signal intensity of nontumorous conditions of corpus callosum on T2-weighted MR images. Forty nine patients with nontumorous high signal intensities involving corpus callosum on sagittal T2-weighted image were retrospectively analyzed. Nontumorous condition of corpus callosum were diffuse axonal injury (DAI, 19 cases), cerebral infarctions (16 cases), multiple sclerosis (MS, 5 cases), Wilson's disease (2 cases) and hydrocephalus (7 cases) that were diagnosed by clinical and MR findings. Numbers, configuration, involved thickness and sites of high signal intensities of corpus callosum were analyzed. DAI and infarctions showed either single or multiple lesions. MS and hydrocephalus showed multiple lesions, but Wilson's diseases showed single lesion. In DAI, infarctions and MS the lesions involved any part of corpus callosum, splenium in Wilson's disease, and all parts of corpus callosum in hydrocephalus. Wilson's disease showed only partial thickness involvement, and others involved partial or full thickness of corpus callosum. Configuration of high signal intensity was linear in most cases of hydrocephalus, and oval in Wilson's disease, and oval and confluent in MS, and variable in DAI and infarctions. High signal intensities of nontumorous conditions of corpus callosum revealed variable findings, and therefore, analysis of nontumorous high signal intensities of corpus callosum is not made by only MR findings but by conjuction with clinical aspects

Experimental study of low-p/sub t/ hadron fragmentation

International Nuclear Information System (INIS)

Cutts, D.; Dulude, R.S.; Lanou, R.E. Jr.; Massimo, J.T.; Meunier, R.; Brenner, A.E.; Carey, D.C.; Elias, J.E.; Garbincius, P.H.

1979-01-01

We present high-statistics results on the reactions a + p → c + X where a and c can be any of π + , K +- , p, or p-bar. The data were taken at 100 and 175 GeV/c incident momenta using the Fermilab Single-Arm Spectrometer operated over the kinematic range 0.2 < x < 1.0 and p/sub t/ < or = 1.0 GeV/c. Investigating the x dependence of the data, we find agreement with a quark-parton picture, namely the cross sections have a power-law behavior in 1 - x independent of p/sub beam/ and p/sub t/

Effects of H2O2 under low- and high-aeration-level conditions on growth and catalase activity in Exiguobacterium oxidotolerans T-2-2T.

Science.gov (United States)

Takebe, Fumihiko; Hara, Isao; Matsuyama, Hidetoshi; Yumoto, Isao

2007-12-01

The effects of H2O2 under low- and high-aeration-level conditions on growth and catalase activity in Exiguobacterium oxidotolerans T-2-2T were investigated. Continuous addition of 5-200 mM H2O2 to the culture medium from the mid-exponential growth phase enhanced the growth of the strain under the low-aeration-level condition, whereas the addition of 5-50 mM H2O2 decreased intracellular specific catalase activity and extracellular total catalases activity. The detection of extracellular catalase by the cells and the decrease in intracellular specific catalase activity and extracellular total catalase activity under the high-aeration-level condition account for the stimulation of growth by the introduced H2O2 and the decrease in catalase activities induced by O(2) from H2O2 in the medium. On the other hand, the addition of H2O2 to the medium prior to the initiation of growth inhibited the growth but increased the specific activity of intracellular catalase in the stationary growth phase. Strain T-2-2T grew when 10 mM H2O2 was added to the medium prior to growth. However, the growth was completely inhibited by the catalase inhibitor 3-amino-1,2,4-triazole (3-AT). The continuous addition of H2O2 at an appropriate concentration from prior to the initiation of growth to the stationary growth phase under the low-aeration-level condition resulted in higher intracellular specific catalase activity and cell growth rate than single H2O2 addition prior to growth.

Microstructural record vs chemical and geochronological preservation in muscovite: implications for P-T-t estimates in deformed metapelites

Science.gov (United States)

Airaghi, Laura; Lanari, Pierre; Warren, Clare J.; de Sigoyer, Julia; Guillot, Stéphane

2017-04-01

Pressure-temperature-deformation (P-T-ɛ) paths for metamorphic rocks commonly relies on the link between successive metamorphic assemblages and the microstructures. However, with increasing P-T conditions, metamorphic minerals in an early microstructure can re-equilibrate by changing their chemical composition. The direct link between deformation phases and mineral compositions for thermobarometry purposes can therefore be distorted. This study focuses on a series of garnet-biotite metapelites from the Longmen Shan (Sichuan, China) that preserve muscovite of different chemistry in distinct microstructures. To quantify the degree of re-equilibration of muscovite, a microstructural study was coupled with high-resolution chemical mapping. Then, the chemical evolution of muscovite (Si4+ and XMg) was modeled using Gibbs free energy minimization along a P-T loop previously constrained by phase equilibria calculations, semi-empirical and empirical thermobarometry. Our results show that the studied metapelites experienced a "typical" three stages metamorphic history: (1) heating and burial up to 11 kbar, 530˚ C, (2) minor decompression and heating up to 6 kbar, 580˚ C and (3) decompression and cooling down to 4-5 kbar, 380-450˚ C. However, muscovite has been partially or completely re-equilibrated during the three stages by idiomorphic replacement, although it is mainly observed in prograde microstructures preceding the pressure peak. The main factors controlling the degree of re-equilibration are the intensity of the deformation and the fluid availability during metamorphism. The P-T conditions of metamorphic assemblages thus reflect pulses of fluids release that enhanced mineral resorption and local replacement. The metamorphic peak (2) was dated by in situ 40Ar/39Ar on biotite porphyroblasts and by in situ (U-Pb)/Th laser ablation on allanite (REE-rich epidote) at 185±15 Ma. Muscovite grains preserved in prograde microstructures and partially re-equilibrated during

Effects of Si δ-Doping Condition and Growth Interruption on Electrical Properties of InP-Based High Electron Mobility Transistor Structures

International Nuclear Information System (INIS)

Zhou Shu-Xing; Qi Ming; Ai Li-Kun; Xu An-Huai; Wang Li-Dan; Ding Peng; Jin Zhi

2015-01-01

The InGaAs/InAlAs/InP high electron mobility transistor (HEMT) structures with lattice-matched and pseudomorphic channels are grown by gas source molecular beam epitaxy. Effects of Si δ-doping condition and growth interruption on the electrical properties are investigated by changing the Si-cell temperature, doping time and growth process. It is found that the optimal Si δ-doping concentration (N_d) is about 5.0 × 10"1"2 cm"−"2 and the use of growth interruption has a dramatic effect on the improvement of electrical properties. The material structure and crystal interface are analyzed by secondary ion mass spectroscopy and high resolution transmission electron microscopy. An InGaAs/InAlAs/InP HEMT device with a gate length of 100 nm is fabricated. The device presents good pinch-off characteristics and the kink-effect of the device is trifling. In addition, the device exhibits f_T = 249 GHz and f_m_a_x > 400 GHz. (paper)

Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison's disease.

Science.gov (United States)

Fichna, Marta; Rogowicz-Frontczak, Anita; Żurawek, Magdalena; Fichna, Piotr; Gryczyńska, Maria; Zozulińska-Ziółkiewicz, Dorota; Ruchała, Marek

2016-07-01

Autoimmune Addison's disease (AAD) associates with exceptional susceptibility to develop other autoimmune conditions, including type 1 diabetes (T1D), marked by positive serum autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and insulinoma-associated protein 2 (IA-2A). Zinc transporter 8 (ZnT8) is a new T1D autoantigen, encoded by the SLC30A8 gene. Its polymorphic variant rs13266634C/T seems associated with the occurrence of serum ZnT8 antibodies (ZnT8A). This study was designed to determine the prevalence of serum ZnT8A and their clinical implication in 140 AAD patients. Other beta cell and thyroid-specific autoantibodies were also investigated, and ZnT8A results were confronted with the rs13266634 genotype. ZnT8A were detectable in 8.5 %, GADA in 20.7 %, IA-2A in 5.7 %, IAA in 1.6 % and various anti-thyroid antibodies in 7.1-67.8 % individuals. Type 1 diabetes was found in 10 % AAD patients. ZnT8A were positive in 57.1 % of T1D patients and 3.4 % non-diabetic AAD. Analysis of ZnT8A enabled to identify autoimmunity in two (14.3 %) T1D individuals previously classified as autoantibody-negative. ZnT8A-positive patients revealed significantly higher number of autoimmune conditions (p < 0.001), increased prevalence of T1D (p < 0.001) and other beta cell-specific autoantibodies. Carriers of the rs13266634 T-allele displayed increased frequency (p = 0.006) and higher titres of ZnT8A (p = 0.002). Our study demonstrates high incidence of ZnT8A in AAD patients. ZnT8A are associated with coexisting T1D and predictive of T1D in non-diabetic subjects. Moreover, positive ZnT8A in AAD indicate elevated risk for additional autoimmune conditions. Autoantibodies to beta cell antigens, comprising ZnT8, could be included in routine screening panels in AAD.

High-p{sub T} B-tagging and top-tagging with variable-R jets in ATLAS

Energy Technology Data Exchange (ETDEWEB)

Behr, Katharina [Sub-department of Particle Physics, University of Oxford, Denys-Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom)

2015-07-01

Variable-R jets, whose effective size is inversely proportional to their transverse momentum, are a versatile tool for object reconstruction across the large transverse momentum regime accessible during Run 2 of the LHC. I discuss the performance of Variable-R jets in two different contexts: (1) Boosted top-tagging. The separation between the decay products of highly energetic top quarks decreases with p{sub T}{sup top} causing them to overlap and merge into a single jet. Taggers relying on large fixed-R jets overestimate the real size of the top jet in the highly boosted regime and are more susceptible to the effects of pile-up. Variable-R jets are studied as the basis for more natural taggers which may not even require grooming. (2) B-tagging. The b-tagging performance in boosted topologies suffers in the presence of close-by jets. This limits the sensitivity of many searches such as those in boosted hh → 4b final states. New b-taggers relying on track jets with smaller sizes than the traditional R=0.4 to better isolate the b-hadron decay show significant improvements in highly boosted scenarios but perform worse at low transverse momenta where they fail to capture the full b-jet. Variable-R track jets provide a unified approach to b-tagging in both p{sub T} regimes.

Significance of lymphadenectomy with splenectomy in radical surgery for advanced (pT3/pT4) remnant gastric cancer.

Science.gov (United States)

Sugita, Hiroki; Oda, Eri; Hirota, Masahiko; Ishikawa, Shinji; Tomiyasu, Shinjiro; Tanaka, Hiroshi; Arita, Tetsumasa; Yagi, Yasushi; Baba, Hideo

2016-04-01

To date, the optimal surgical strategy for remnant gastric cancer has not been determined. The purpose of this study was to clarify the significance of lymphadenectomy with splenectomy in remnant gastric cancer surgery. This retrospective cohort study was conducted at the Kumamoto Regional Medical Center. The primary endpoint was overall survival after surgery. We retrospectively analyzed the clinicopathologic features, surgical treatments, and long-term prognosis of remnant gastric cancer patients treated with total gastrectomy. A total of 80 patients with gastric cancer in the remnant stomach after distal gastrectomy and who underwent total gastrectomy were enrolled in the study. Splenectomy was performed in 38 patients. Lymph node metastasis in the splenic hilum was not observed in the patients with pT1/pT2 tumors, whereas nodal metastasis at the splenic hilum was detected in 30.4% of the patients with pT3/pT4 tumors. The survival rate of the patients with pT3/pT4 tumors who underwent splenectomy was significantly higher than that of the patients who did not undergo splenectomy, although there was no difference in the patients with pT1/pT2 tumors. Among the patients classified as R0, the survival rate of the patients with pT3/pT4 tumors who underwent splenectomy was significantly higher than that of the patients who did not undergo splenectomy. Lymphadenectomy with splenectomy in radical surgery is beneficial for patients with advanced (pT3/pT4) remnant gastric cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

P-T-t-d History of the Lahul Valley, NW Indian Himalaya

Science.gov (United States)

Nieblas, A.; Leech, M. L.

2015-12-01

The Lahul Valley of NW India is located between the Zanskar Shear zone to the northwest and the Sangla detachment to the southeast. This region contains three east-trending, laterally-continuous tectonostratigraphic units separated by two major fault zones. To the south, low-grade metasediments of the Lesser Himalayan Sequence (LHS) are separated from high-grade crystalline rocks of the Greater Himalayan Sequence (GHS) by the north dipping Main Central Thrust (MCT). The northern extent of the GHS is separated from overlying low-grade sedimentary rocks of the Tethyan Himalayan Sequence (THS) along the north dipping South Tibetan Detachment System (STDS). There is controversy over the location and type of shear motion for the STDS in the ~50 km strip running through Lahul Valley where the STD is interpreted as a discrete fault, a dextral shear zone, and is unidentified in some areas along the trend of the STDS. This study focuses on understanding the pressure-temperature-time-deformation (P-T-t-d) evolution of THS and GHS rocks in Lahul Valley to better understand regional Cenozoic deformation and the location and role of the STDS in the extrusion of the GHS. Deformed granitics, migmatites, and leucogranites from the GHS contain a dominant mineralogy of Qz + Kfs + Pl + Bt + Ms ± Grt ± Ky ± St. Schists and phyllites from the THS contain a dominant mineralogy of Qz + Kfs + Pl + Bt + Ms ± Grt. Isochemical phase equilibria diagrams (pseudosections) are calculated in Perple_X using whole-rock chemistry data with solution models based on these mineral assemblages. Ti-in-quartz thermometry and the Fe-Mg exchange thermometry from garnet-biotite pairs used with mineral growth relationships constrain conditions during deformation and to establish P-T paths. U-Pb SHRIMP dating of zircon constrains peak metamorphic conditions and 40Ar/39Ar thermochronology of micas provide the cooling history along the valley and across the STDS. This multi-component approach to understand

Interplay of soft and hard processes and hadron $p_{T}$ spectra in p A and AA collisions

CERN Document Server

Enke, Wang; 10.1103/PhysRevC.64.034901

2001-01-01

Motivated by a schematic model of multiple parton scattering within the Glauber formalism, the transverse momentum spectra in pA and AA collisions are analyzed in terms of a nuclear modification factor with respect to pp collisions. The existing data at the CERN Super Proton Synchrotron energies are shown to be consistent with the picture of Glauber multiple scattering in which the interplay between soft and hard processes and the effect of absorptive processes lead to nontrivial nuclear modification of the particle spectra. Relative to the additive model of incoherent hard scattering, the spectra are enhanced at large p/sub T/ (hard) by multiple scattering while suppressed at low p/sub T/ (soft) by absorptive correction with the transition occurring at around a scale p/sub 0/~1-2 GeV/c that separates soft and hard processes. Around the same scale, the p/sub T / spectra in pp collisions also change from an exponential form at low p/sub T/ to a power-law behavior at high p/sub T/. At very large p/sub T/>>p/sub...

Mechanisms of the p(He 6,He 5)d, p(He 6,α)t and p(He 6,t)α reactions

International Nuclear Information System (INIS)

Heiberg-Andersen, Henning

2002-07-01

This work was devoted to nucleon induced transfer reactions having the potential to probe the sub-cluster structures of the benchmark halo nucleus He 6, without the question marks the necessarily omitted exchange effects tend to put behind the CRC results when both collision partners are composite systems. Still, the exchange complications entered the analysis in an ironic way: The high Q-value of the p(He 6,α)t and p(He 6, t)α reactions caused sensitivity to the t - α optical potential at small radii, where the one-nucleon exchange effects are strongest. Since the attempt to throw them out of the extracted tau - α potential failed, it was necessary to extend the model space to avoid a too difficult modelling of the local equivalent t - α potential. By this step, all the complications originating from antisymmetrization within a larger model space entered the analysis. However, the persistent failures of the two-channel calculations of this and previous works can hardly be due to incorrect treatment of exchange effects only, so the loss of simplicity is probably illusory. Even at small angles, where the surface processes dominate, none of the two-channel calculations with various choices of t - α optical potentials managed to reproduce the p(He 6, α)t (p(He 6,t)α) data. This motivated inclusion of sequential transfers through the d + He 5 channel, where the sequential triton transfer process, included just for consistency in the coupling scheme of the four-channel calculation, turned out to be more influent than expected. The satisfactory reproduction of both the p(He 6, He 5)d and the p(He 6,α)t (p(He 6,t)α) data by the four-channel approach and the required re-normalization the real part of the p - He 6 optical potential are strong indications of substantial contributions from sequential transfer of the halo neutrons at this energy. The conclusions that can be drawn from this work are limited by the modest amount of available data. This limitation does

Mechanisms of the p(He 6,He 5)d, p(He 6,{alpha})t and p(He 6,t){alpha} reactions

Energy Technology Data Exchange (ETDEWEB)

Heiberg-Andersen, Henning

2002-07-01

This work was devoted to nucleon induced transfer reactions having the potential to probe the sub-cluster structures of the benchmark halo nucleus He 6, without the question marks the necessarily omitted exchange effects tend to put behind the CRC results when both collision partners are composite systems. Still, the exchange complications entered the analysis in an ironic way: The high Q-value of the p(He 6,{alpha})t and p(He 6, t){alpha} reactions caused sensitivity to the t - {alpha} optical potential at small radii, where the one-nucleon exchange effects are strongest. Since the attempt to throw them out of the extracted tau - {alpha} potential failed, it was necessary to extend the model space to avoid a too difficult modelling of the local equivalent t - {alpha} potential. By this step, all the complications originating from antisymmetrization within a larger model space entered the analysis. However, the persistent failures of the two-channel calculations of this and previous works can hardly be due to incorrect treatment of exchange effects only, so the loss of simplicity is probably illusory. Even at small angles, where the surface processes dominate, none of the two-channel calculations with various choices of t - {alpha} optical potentials managed to reproduce the p(He 6, {alpha})t (p(He 6,t){alpha}) data. This motivated inclusion of sequential transfers through the d + He 5 channel, where the sequential triton transfer process, included just for consistency in the coupling scheme of the four-channel calculation, turned out to be more influent than expected. The satisfactory reproduction of both the p(He 6, He 5)d and the p(He 6,{alpha})t (p(He 6,t){alpha}) data by the four-channel approach and the required re-normalization the real part of the p - He 6 optical potential are strong indications of substantial contributions from sequential transfer of the halo neutrons at this energy. The conclusions that can be drawn from this work are limited by the

Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen.

Science.gov (United States)

O'Neill, F J; Hu, Y; Chen, T; Carney, H

1997-02-27

In several clones of SV40-transformed human cells, we investigated the relative amounts of large T-Antigen (T-Ag) and p53 proteins, both unbound and associated within complexes, with the goal of identifying changes associated with transformation and immortalization. Cells were transformed by wild type (wt) T-Ag, a functionally temperature sensitive T-Ag (tsA58) and other T-Ag variants. Western analysis showed that while most of the T-Ag was ultimately bound by p53, most of the p53 remained unbound to T-Ag. Unbound p53 remained in the supernatant after a T-Ag immunoprecipitation and p53 was present in two to fourfold excess of T-Ag. In one transformant there was five to tenfold more p53 than T-Ag. p53 was present in transformants in amounts at least 200-fold greater than in untransformed human cells. In wt and variant T-Ag transformants, including those generated with tsA58 T-Ag, large amounts of unbound p53 were present in both pre-crisis and immortal cells and when the cells were grown at permissive or non-permissive temperatures. We also found that in transformants produced by tsA58, an SV40/JCV chimeric T-Ag and other variants, T-Ag appeared to form a complex with p53 slowly perhaps because one or both proteins matured slowly. The presence in transformed human cells of large amounts of unbound p53 and in excess of T-Ag suggests that sequestration of p53 by T-Ag, resulting from complex formation, is required neither for morphological transformation nor immortalization of human cells. Rather, these results support the proposal that high levels of p53, the T-Ag/p53 complexes, or other biochemical event(s), lead to transformation and immortalization of human cells by T-Ag.

Metamorphic P-T conditions and CO2 influx history of medium-grade metapelites from Karakorum, Trans-Himalaya, India

Science.gov (United States)

Sachan, Himanshu K.; Santosh, M.; Prakash, Divya; Kharya, Aditya; Chandra Singh, P.; Rai, Santosh K.

2016-07-01

The medium grade metapelites of Pangong-Tso area in the trans-Himalayan region underwent sillimanite-grade metamorphism initiated during the Cretaceous, associated with the collision of the Kohistan arc and the Indian plate with Asia. This paper present results from a petrological and fluid inclusion study to understand the metamorphic P-T conditions and fluid history of these rocks. The calculated phase equilibria in the Na2O-CaO-K2O-FeO-MgO-MnO-Al2O3-SiO2-H2O-TiO2 (NCKFMMnASHT) system suggest P-T conditions of 8 kbar and 650 °C for the peak metamorphic event. Primary fluid inclusions occur in staurolite and garnet, whereas quartz carries mostly secondary fluid inclusions. The trapped fluids in primary inclusions show initial melting temperatures in the range of -56.9 to -56.6 °C, suggesting nearly pure CO2 composition. The secondary fluids are of mixed carbonic-aqueous nature. The re-equilibrated inclusions show annular morphology as well as necking phenomena. The CO2 isochores for the primary inclusions indicate pressures of 6.1-6.7 kbar, suggesting that the CO2-rich fluids were trapped during post-peak exhumation of the rocks, or that synmetamorphic carbonic fluids underwent density reversal during isothermal decompression. The secondary CO2-H2O fluids must have been trapped during the late exhumation stage, as their isochores define further lower pressures of 4.8 kbar. The morphology of re-equilibrated fluid inclusions and the rapid decrease in pressure are consistent with a near-isothermal decompression trajectory following the peak metamorphism. The carbonic fluids were probably derived locally from decarbonation reactions of the associated carbonate rocks during metamorphism or from a deep-seated reservoir through Karakorum fault.

Transverse momentum and centrality dependence of high-pT nonphotonic electron suppression in Au+Au collisions at sqrt[s NN]=200 GeV.

Science.gov (United States)

Abelev, B I; Aggarwal, M M; Ahammed, Z; Anderson, B D; Arkhipkin, D; Averichev, G S; Bai, Y; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Baumgart, S; Belaga, V V; Bellingeri-Laurikainen, A; Bellwied, R; Benedosso, F; Betts, R R; Bhardwaj, S; Bhasin, A; Bhati, A K; Bichsel, H; Bielcik, J; Bielcikova, J; Bland, L C; Blyth, S-L; Bombara, M; Bonner, B E; Botje, M; Bouchet, J; Brandin, A V; Bravar, A; Burton, T P; Bystersky, M; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca Sánchez, M; Callner, J; Catu, O; Cebra, D; Chajecki, Z; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, J H; Chen, J Y; Cheng, J; Cherney, M; Chikanian, A; Christie, W; Chung, S U; Coffin, J P; Cormier, T M; Cosentino, M R; Cramer, J G; Crawford, H J; Das, D; Dash, S; Daugherity, M; de Moura, M M; Dedovich, T G; Dephillips, M; Derevschikov, A A; Didenko, L; Dietel, T; Djawotho, P; Dogra, S M; Dong, X; Drachenberg, J L; Draper, J E; Du, F; Dunin, V B; Dunlop, J C; Dutta Mazumdar, M R; Eckardt, V; Edwards, W R; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Estienne, M; Fachini, P; Fatemi, R; Fedorisin, J; Feng, A; Filip, P; Finch, E; Fine, V; Fisyak, Y; Fu, J; Gagliardi, C A; Gaillard, L; Ganti, M S; Garcia-Solis, E; Ghazikhanian, V; Ghosh, P; Gorbunov, Y G; Gos, H; Grebenyuk, O; Grosnick, D; Guertin, S M; Guimaraes, K S F F; Gupta, N; Haag, B; Hallman, T J; Hamed, A; Harris, J W; He, W; Heinz, M; Henry, T W; Heppelmann, S; Hippolyte, B; Hirsch, A; Hjort, E; Hoffman, A M; Hoffmann, G W; Hofman, D; Hollis, R; Horner, M J; Huang, H Z; Hughes, E W; Humanic, T J; Igo, G; Iordanova, A; Jacobs, P; Jacobs, W W; Jakl, P; Jia, F; Jones, P G; Judd, E G; Kabana, S; Kang, K; Kapitan, J; Kaplan, M; Keane, D; Kechechyan, A; Kettler, D; Khodyrev, V Yu; Kim, B C; Kiryluk, J; Kisiel, A; Kislov, E M; Klein, S R; Knospe, A G; Kocoloski, A; Koetke, D D; Kollegger, T; Kopytine, M; Kotchenda, L; Kouchpil, V; Kowalik, K L; Kravtsov, P; Kravtsov, V I; Krueger, K; Kuhn, C; Kulikov, A I; Kumar, A; Kurnadi, P; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Lapointe, S; Laue, F; Lauret, J; Lebedev, A; Lednicky, R; Lee, C-H; Lehocka, S; LeVine, M J; Li, C; Li, Q; Li, Y; Lin, G; Lin, X; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, H; Liu, J; Liu, L; Ljubicic, T; Llope, W J; Longacre, R S; Love, W A; Lu, Y; Ludlam, T; Lynn, D; Ma, G L; Ma, J G; Ma, Y G; Magestro, D; Mahapatra, D P; Majka, R; Mangotra, L K; Manweiler, R; Margetis, S; Markert, C; Martin, L; Matis, H S; Matulenko, Yu A; McClain, C J; McShane, T S; Melnick, Yu; Meschanin, A; Millane, J; Miller, M L; Minaev, N G; Mioduszewski, S; Mironov, C; Mischke, A; Mitchell, J; Mohanty, B; Morozov, D A; Munhoz, M G; Nandi, B K; Nattrass, C; Nayak, T K; Nelson, J M; Nepali, N S; Netrakanti, P K; Nogach, L V; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Pachr, M; Pal, S K; Panebratsev, Y; Pavlinov, A I; Pawlak, T; Peitzmann, T; Perevoztchikov, V; Perkins, C; Peryt, W; Phatak, S C; Planinic, M; Pluta, J; Poljak, N; Porile, N; Poskanzer, A M; Potekhin, M; Potrebenikova, E; Potukuchi, B V K S; Prindle, D; Pruneau, C; Putschke, J; Qattan, I A; Raniwala, R; Raniwala, S; Ray, R L; Relyea, D; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevskiy, O V; Romero, J L; Rose, A; Roy, C; Ruan, L; Russcher, M J; Sahoo, R; Sakrejda, I; Sakuma, T; Salur, S; Sandweiss, J; Sarsour, M; Sazhin, P S; Schambach, J; Scharenberg, R P; Schmitz, N; Seger, J; Selyuzhenkov, I; Seyboth, P; Shabetai, A; Shahaliev, E; Shao, M; Sharma, M; Shen, W Q; Shimanskiy, S S; Sichtermann, E P; Simon, F; Singaraju, R N; Smirnov, N; Snellings, R; Sorensen, P; Sowinski, J; Speltz, J; Spinka, H M; Srivastava, B; Stadnik, A; Stanislaus, T D S; Staszak, D; Stock, R; Strikhanov, M; Stringfellow, B; Suaide, A A P; Suarez, M C; Subba, N L; Sumbera, M; Sun, X M; Sun, Z; Surrow, B; Symons, T J M; Szanto de Toledo, A; Takahashi, J; Tang, A H; Tarnowsky, T; Thomas, J H; Timmins, A R; Timoshenko, S; Tokarev, M; Trainor, T A; Trentalange, S; Tribble, R E; Tsai, O D; Ulery, J; Ullrich, T; Underwood, D G; Van Buren, G; van der Kolk, N; van Leeuwen, M; Vander Molen, A M; Varma, R; Vasilevski, I M; Vasiliev, A N; Vernet, R; Vigdor, S E; Viyogi, Y P; Vokal, S; Voloshin, S A; Waggoner, W T; Wang, F; Wang, G; Wang, J S; Wang, X L; Wang, Y; Watson, J W; Webb, J C; Westfall, G D; Wetzler, A; Whitten, C; Wieman, H; Wissink, S W; Witt, R; Wu, J; Wu, Y; Xu, N; Xu, Q H; Xu, Z; Yepes, P; Yoo, I-K; Yue, Q; Yurevich, V I; Zhan, W; Zhang, H; Zhang, W M; Zhang, Y; Zhang, Z P; Zhao, Y; Zhong, C; Zhou, J; Zoulkarneev, R; Zoulkarneeva, Y; Zubarev, A N; Zuo, J X

2007-05-11

The STAR collaboration at the BNL Relativistic Heavy-Ion Collider (RHIC) reports measurements of the inclusive yield of nonphotonic electrons, which arise dominantly from semileptonic decays of heavy flavor mesons, over a broad range of transverse momenta (1.2<p(T)<10 GeV/c) in p+p, d+Au, and Au+Au collisions at sqrt[s_{NN}]=200 GeV. The nonphotonic electron yield exhibits an unexpectedly large suppression in central Au+Au collisions at high p(T), suggesting substantial heavy-quark energy loss at RHIC. The centrality and p(T) dependences of the suppression provide constraints on theoretical models of suppression.

Azimuthal correlations of high-p{sub T} photons and hadrons in Au+Au collisions at STAR

Energy Technology Data Exchange (ETDEWEB)

Dietel, T.

2006-07-01

The STAR experiment observed a modification of the azimuthal correlations between a trigger particle and associated particles in central Au+Au collisions, where trigger particles with 4 GeV<p{sub T}{sup trigger}<6 GeV and associated particles with 2GeV<p{sub T}{sup trigger}<4 GeV were selected. This thesis studies azimuthal correlations between regions of high energy deposition in the electro-magnetic calorimeter as trigger- and charged tracks as associated particles. The data sample had been enriched by online event selection, allowing for the selection of trigger particles with a transverse energy of more than 10 GeV and associated particles with more than 2, 3 or 4 GeV. The trigger particles are a mixture of photon pairs from the decays of neutral pions and single photons, mainly from photon-jet events, with small contributions from other hadron decays and fragmentation photons. (orig.)

Hydrogen-deuterium exchange and mass spectrometry reveal the pH-dependent conformational changes of diphtheria toxin T domain.

Science.gov (United States)

Li, Jing; Rodnin, Mykola V; Ladokhin, Alexey S; Gross, Michael L

2014-11-04

The translocation (T) domain of diphtheria toxin plays a critical role in moving the catalytic domain across the endosomal membrane. Translocation/insertion is triggered by a decrease in pH in the endosome where conformational changes of T domain occur through several kinetic intermediates to yield a final trans-membrane form. High-resolution structural studies are only applicable to the static T-domain structure at physiological pH, and studies of the T-domain translocation pathway are hindered by the simultaneous presence of multiple conformations. Here, we report the application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) for the study of the pH-dependent conformational changes of the T domain in solution. Effects of pH on intrinsic HDX rates were deconvolved by converting the on-exchange times at low pH into times under our "standard condition" (pH 7.5). pH-Dependent HDX kinetic analysis of T domain clearly reveals the conformational transition from the native state (W-state) to a membrane-competent state (W(+)-state). The initial transition occurs at pH 6 and includes the destabilization of N-terminal helices accompanied by the separation between N- and C-terminal segments. The structural rearrangements accompanying the formation of the membrane-competent state expose a hydrophobic hairpin (TH8-9) to solvent, prepare it to insert into the membrane. At pH 5.5, the transition is complete, and the protein further unfolds, resulting in the exposure of its C-terminal hydrophobic TH8-9, leading to subsequent aggregation in the absence of membranes. This solution-based study complements high resolution crystal structures and provides a detailed understanding of the pH-dependent structural rearrangement and acid-induced oligomerization of T domain.

Fuel cycle integration issues associated with P/T technology

International Nuclear Information System (INIS)

Michaels, G.E.; Ludwig, S.B.

1992-01-01

The three primary interfaces between a generic partitioning and transmutation (P/T) technology and the existing United States fuel cycle are the light-water reactor (LWR) spent fuel inventory, the reprocessed uranium (RU) stream, and the high-level waste stream. The features and implications of these three interfaces are reviewed and their implications for P/T system design and for waste management are assessed. The variability of transuranic nuclide composition in the LWR spent fuel is calculated and its potential implications for transmutation system core design are discussed. The radiological characteristics of the RU stream are presented, and options for disposition of the stream are reviewed. Most P/T scenarios assume that RU will be recycled to LWRs. This study demonstrates, however, that LWR recycle cannot totally consume the reprocessed stream, and disposal of a waste uranium steam with high levels of radiologically-significant isotopes will still be necessary. The radioactivity of the tails stream for enrichment plants resulting from a dedicated RU campaign is calculated. The tendency of gaseous diffusion plant enrichment technology to deplete the tails stream of minor uranium isotopes is seen as a benefit and an advantage over Atomic Vapor Laser Isotope Separation-type technology. Finally, the implications of P/T on LWR-origin wastes reporting to the repository is discussed, and several significant differences between LWR-origin waste originating from transmutation systems are assessed

Magnetization at high pressure in CeP

Science.gov (United States)

Naka, T.; Matsumoto, T.; Okayama, Y.; Môri, N.; Haga, Y.; Suzuki, T.

1995-02-01

We have investigated the pressure dependence of magnetization below 60 K up to 1.6 GPa in the low-carrier concentration system CeP showing two step transitions at T = TL and TH under high pressure. At high pressure, M( P, T) exhibits a maximum at around the lower transition temperature TL. This behavior implies that the magnetic state changes at TL. The pressure dependence of isothermal magnetization M( P) is different above and below TL. In fact, M( P) below TL exhibits a maximum at around 1.4 GPa, whereas M( P) above TL increases steeply with pressure up to 1.6 GPa.

Recent results from PHOBOS on particle production at high p T

Science.gov (United States)

Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Chai, Z.; Chetluru, V.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Halliwell, C.; Hamblen, J.; Harnarine, I.; Hauer, M.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Holyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Li, W.; Lin, W. T.; Loizides, C.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Reed, C.; Richardson, E.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Szostak, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Walters, P.; Wenger, E.; Willhelm, D.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wyngaardt, S.; Wysłouch, B.

2009-06-01

A selection of experimental results from the PHOBOS Collaboration relevant for probing high-energy nuclear collisions with high transverse momentum particles is presented. The inclusive yields of charged particles and comparisons between nuclear and elementary collisions already reveal a large amount of parton energy loss in the hot and dense medium created in heavy ion collisions. Remarkable scaling and factorization features are observed, unifying the data taken at various collision energies, centralities and nuclear sizes. To further analyze the nature of the energy loss, a measurement of pseudorapidity (Δ η) and azimuthal angle (Δ φ) correlations between high transverse momentum charged hadrons ( p T >2.5 GeV/ c) and all associated charged particles is presented at both short-range (small Δ η) and long-range (large Δ η) over a continuous detector acceptance covering -4<Δ η<2. Various near- and away-side features of the correlation structure are discussed as a function of centrality in Au + Au collisions at sqrt{s_{NN}}=200 GeV. The results provide new information about the longitudinal (Δ η) extent of the near-side ‘ridge’ structure, first observed by the STAR Collaboration over a narrower η range. In central Au + Au collisions the ridge structure extends to at least Δ η=4, and its strength completely diminishes as collisions become more peripheral.

Acanthamoeba belonging to T3, T4, and T11: genotypes isolated from air-conditioning units in Santiago, Chile.

Science.gov (United States)

Astorga, Berbeli; Lorenzo-Morales, Jacob; Martín-Navarro, Carmen M; Alarcón, Verónica; Moreno, Johanna; González, Ana C; Navarrete, Elizabeth; Piñero, José E; Valladares, Basilio

2011-01-01

Free-living amoebae (FLA) of the genus Acanthamoeba are widely distributed in the environment, in the air, soil, and water, and have also been isolated from air-conditioning units. The objective of this work was to investigate the presence of this genus of FLA in the air-conditioning equipment at the Institute of Public Health of Chile in Santiago, Chile. Water and air samples were collected from air-conditioning systems and were checked for the presence of Acanthamoeba spp. Positive samples were further classified at the genotype level after sequencing the highly variable diagnostic fragment 3 (DF3) region of the 18S rRNA gene. This is the first report of the T3, T4, and T11 genotypes of Acanthamoeba in air-conditioning units from Chile. Overall, the widespread distribution of potentially pathogenic Acanthamoeba strains in the studied source demands more awareness within the public and health professionals in Chile as this pathogen is emerging as a risk for human health worldwide. © 2011 The Author(s) Journal of Eukaryotic Microbiology © 2011 International Society of Protistologists.

Hadronic final states in high -pT QCD at CDF

Energy Technology Data Exchange (ETDEWEB)

Matera, Keith [University of Illinois, Urbana-Champaign

2013-11-18

The heavy quark content of gauge boson events is of great interest to studies of QCD. These events probe the gluon and heavy-quark parton distribution functions of the proton, and also provide a measurement of the rate of final state gluon splitting to heavy flavor. In addition, gauge boson plus heavy quark events are representative of backgrounds to Higgs, single top, and supersymmetric particle searches. Recent work with the CDF II detector at the Fermilab Tevatron has measured the cross-section of several gauge boson plus heavy flavor production processes, including the first Tevatron observation of specific charm process p{p bar} → W +c. Results are found to be in agreement with NLO predictions that include an enhanced rate of g → {cc bar}/bb splitting. Lastly, a new analysis promises to probe a lower pT (c) region than has been previously explored, by fully reconstructing D* → D0(Kπ)π decays in the full CDF dataset (9.7 fb-1).

Transverse momentum of partons. From low to high pT

International Nuclear Information System (INIS)

Diehl, Markus

2008-11-01

Transverse-momentum spectra in hard processes are typically described either in terms of intrinsic transverse momentum of partons, or in terms of perturbative radiation. The relation between these descriptions is discussed for the example of semi-inclusive deep inelastic scattering, with special focus on the angular distribution of the observed hadron. This involves nontrivial theoretical issues, such as the proper definition of transverse-momentum dependent parton distributions, and has practical consequences for the description of p T spectra in phenomenology. (orig.)

Specific aspects in the manufacturing and operating of CANDU reactor pressure tubes (P/T)

International Nuclear Information System (INIS)

Muscaloiu, C.

1997-01-01

The CANDU reactor design is based on a number of individual P/T in which nuclear fuel bundles are located. P/T are required to be operated in an environment of elevated temperature (300 o C), internal pressure (10 Mpa), fast neutron flux (E>1 MeV) and heavy water. The most suitable material which can provide the desired neutron economy and still maintain its mechanical properties along with corrosion resistance is zirconium alloys Zr+ 2.5 % Nb with the following composition: niobium, 2.5 to 2.8 weight percent; oxygen, 1,000 to 1,300 ppm; zirconium + allowed impurities - balance. A total of 380 pressure tubes are installed into reactor. Each pressure tube is attached at each end to a stainless steel end fitting by means of a grooved, expanded joint. The installation works were performed by ANM Bucuresti, under the technical support of General Electric Canada. The integrity of P/T after installation was examined as follows: - the surface of the rolled area on unrolled internal surface extending 25 mm beyond rolled area was inspected for irregularities by means of a boroscope; - all pressure tubes were subjected to the helium leak test after F/C installation. During P/T operating life periodical inspections according to Canadian Standard CSA N285.4 are performed. The selection of the P/T for inspection is based either on particular properties or on the operating conditions of the fuel channel. The inspection consists in: a) Base Line Inspection within 2 years period commencing after 7,000 EFPH of operation which will include a volumetric inspection over P/T full length and measurements of P/T sag, ID, wall thickness and F/C bearing positions; b) Periodic Inspection in the same conditions plus material surveillance (on the four most significant indication P/T detected during the Base Line Inspection). The inspection will be performed on 14 selected P/T. (author)

Large p sub(T) π0 production in high energy αα collisions: strange or normal

International Nuclear Information System (INIS)

Wilk, G.

1982-01-01

Abnormally large yield of π 0 with large p sub(T) was measured at 90 deg in the nucleon-nucleon CM frame in the αα collisions at CERN-ISR. The maximal momenta of the beams corresponded to p=31.5 GeV/c per charge: The reaction of corresponding inclusive cross sections for αα and pp collisions grows with p sub(T) well above the expected value R=16 (for helium nuclei) reaching R=40-60 for p sub(T) approx.=7 GeV/c. In this talk author tries to answer the question if this result is strange or normal. (M.F.W.)

Defect engineering for 650 nm high-power AlGaInP laser diodes

International Nuclear Information System (INIS)

Kim, D.S.; Kim, K.C.; Shin, Y.C.; Kang, D.H.; Kim, B.J.; Kim, Y.M.; Park, Y.; Kim, T.G.

2006-01-01

To find the optimal growth and annealing conditions for high-power 650 nm band AlGaInP laser diodes, we carried out defect engineering, in which the distribution and density of deep level defects of the laser structure was analyzed. For this purpose, deep level transient spectroscopy (DLTS) measurements were carried out for each layer of the 650 nm band AlGaInP laser. By layer optimization at growth and annealing conditions, the laser diode was able operate stably and kink-free at high power over 220 mW at 70 deg. C. The characteristic temperatures (T ) were 212 K for 25-60 deg. C and 106 K over 60 deg. C

High spatial resolution 3D MR cholangiography with high sampling efficiency technique (SPACE): Comparison of 3 T vs. 1.5 T

Energy Technology Data Exchange (ETDEWEB)

Arizono, Shigeki [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: arizono@kuhp.kyoto-u.ac.jp; Isoda, Hiroyoshi [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: sayuki@kuhp.kyoto-u.ac.jp; Maetani, Yoji S. [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: mbo@kuhp.kyoto-u.ac.jp; Hirokawa, Yuusuke [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: yuusuke@kuhp.kyoto-u.ac.jp; Shimada, Kotaro [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: kotaro@kuhp.kyoto-u.ac.jp; Nakamoto, Yuji [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: ynakamo1@kuhp.kyoto-u.ac.jp; Shibata, Toshiya [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: ksj@kuhp.kyoto-u.ac.jp; Togashi, Kaori [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 (Japan)], E-mail: ktogashi@kuhp.kyoto-u.ac.jp

2010-01-15

Purpose: The aim of this study was to evaluate image quality of 3D MR cholangiography (MRC) using high sampling efficiency technique (SPACE) at 3 T compared with 1.5 T. Methods and materials: An IRB approved prospective study was performed with 17 healthy volunteers using both 3 and 1.5 T MR scanners. MRC images were obtained with free-breathing navigator-triggered 3D T2-weighted turbo spin-echo sequence with SPACE (TR, >2700 ms; TE, 780 ms at 3 T and 801 ms at 1.5 T; echo-train length, 121; voxel size, 1.1 mm x 1.0 mm x 0.84 mm). The common bile duct (CBD) to liver contrast-to-noise ratios (CNRs) were compared between 3 and 1.5 T. A five-point scale was used to compare overall image quality and visualization of the third branches of bile duct (B2, B6, and B8). The depiction of cystic duct insertion and the highest order of bile duct visible were also compared. The results were compared using the Wilcoxon signed-ranks test. Results: CNR between the CBD and liver was significantly higher at 3 T than 1.5 T (p = 0.0006). MRC at 3 T showed a significantly higher overall image quality (p = 0.0215) and clearer visualization of B2 (p = 0.0183) and B6 (p = 0.0106) than at 1.5 T. In all analyses of duct visibility, 3 T showed higher scores than 1.5 T. Conclusion: 3 T MRC using SPACE offered better image quality than 1.5 T. SPACE technique facilitated high-resolution 3D MRC with excellent image quality at 3 T.

Large p sub( t) phenomena and the structure of jets

International Nuclear Information System (INIS)

Sosnowski, R.

1979-01-01

The modern history of high transverse momentum phenomena started in 1972 when it was found that the spectrum of the transverse momentum p sub(T) of secondaries produced in hadronic collisions did not drop as fast as expected from its behavior at low transverse momentum. Now it is possible to study the production of secondaries at transverse momenta as high as 16 GeV/c. The aim of this review is to systematize the existing experimental knowledge in this field. It is believed that the production of objects with high transverse momenta in the collision of two hadrons is due to the hard scattering of their constituents. According to this hard scattering picture, in the collision causing hard scattering, two scattered constituents with high transverse momenta should show up as two jets of hadrons, trigger jet and away jet. Two incoming hadrons, one constituent is removed by hard scattering from each, are expected to create two spectator jets. The present review is made through the four-jet world. The experimental studies of high p sub(T) phenomena in hadronic collision showed this four-jet structure. The observed structure is consistent with the assumption that high p sub(T) objects originate from scattered hadronic constituents. Many aspects of the collision indicate that the scattering constituents are quarks. (Kako, I.)

Proceedings of RIKEN BNL Research Center Workshop: Progress in High-pT Physics at RHIC

Energy Technology Data Exchange (ETDEWEB)

Bazilevsky, A.; Bland, L.; Vogelsang, W.

2010-03-17

This volume archives the presentations at the RIKEN BNL Research Center workshop 'Progress in High-PT Physics at RHIC', held at BNL in March 2010. Much has been learned from high-p{sub T} physics after 10 years of RHIC operations for heavy-ion collisions, polarized proton collisions and d+Au collisions. The workshop focused on recent progress in these areas by both theory and experiment. The first morning saw review talks on the theory of RHIC high-p{sub T} physics by G. Sterman and J. Soffer, and on the experimental results by M. Tannenbaum. One of the most exciting recent results from the RHIC spin program is the first observation of W bosons and their associated single-spin asymmetry. The new preliminary data were reported on the first day of our workshop, along with a theoretical perspective. There also were detailed discussions on the global analysis of polarized parton distributions, including the knowledge on gluon polarization and the impact of the W-data. The main topic of the second workshop day were single-transverse spin asymmetries and their analysis in terms of transverse-momentum dependent parton distributions. There is currently much interest in a future Drell-Yan program at RHIC, thanks to the exciting physics opportunities this would offer. This was addressed in some of the talks. There also were presentations on the latest results on transverse-spin physics from HERMES and BELLE. On the final day of the workshop, the focus shifted toward forward and small-x physics at RHIC, which has become a cornerstone of the whole RHIC program. Exciting new data were presented and discussed in terms of their possible implications for our understanding of strong color-field phenomena in QCD. In the afternoon, there were discussions of nuclear parton distributions and jet observables, among them fragmentation. The workshop was concluded with outlooks toward the near-term (LHC, JLab) and longer-term (EIC) future. The workshop has been a great success

Prospects for measuring the differential high pT b-jet cross section with the ATLAS detector

International Nuclear Information System (INIS)

Grybel, Kai Karsten

2011-01-01

Currently, the Large Hadron Collider (LHC) at CERN in Geneva accelerates protons up to an energy of 3.5 TeV resulting in collisions of a center-of-mass energy of √(s)=7 TeV. To study the production of b-quarks in proton-proton collisions is part of the physics program of the ATLAS experiment, which is one of the experiments at the LHC. The b-quarks produced in the hard scattering of the protons are measured as jets in the ATLAS detector. The aim of this PhD thesis is to study prospects of a differential p T b-jet cross section measurement in the jet p T range of p Tjet > 30 GeV. This study is based on simulated Monte Carlo (MC) data assuming a center-of-mass energy of √(s)=10 TeV. The trigger selection is based on a combination of single jet triggers considering the different prescale factors of the different jet triggers. The MC data samples contain signal b-jets and background jets from other QCD physics processes in the proton-proton collision. In order to identify the b-jets and to reject background jets, b-tagging algorithms based on the on average longer lifetime of particles containing a b-quark compared to other hadrons, which decay before reaching the detector, are used. Since the b-tagging performance is not uniform over the jet p T region considered, different b-tagging efficiency scenarios are studied. The jet p T independent b-tagging efficiency scenarios of ε Tag =0.5 and ε Tag =0.6 as well as an optimized b-tagging efficiency scenario in order to minimize the statistical uncertainty of the measurement in each jet p T bin are presented. An unfolding algorithm is applied to the measured b-jet spectrum in order to correct for detector effects due to the measuring process. The expected systematic uncertainties for different jet p T regions are studied and an estimate for the evolvement of the statistical uncertainties as a function of the integrated luminosity is given. Once an integrated luminosity of at least 100 pb -1 has been collected the

At what conditions does zircon grow/dissolve during high-T metamorphism? Relating zircon textures to PT-conditions

Science.gov (United States)

Kunz, Barbara E.; Regis, Daniele; Manzotti, Paola; Engi, Martin

2015-04-01

A key question in ziconology is when and how zircon grows during metamorphism. To shed light on zircon forming processes and the corresponding PT-conditions during high-T metamorphism a case study was undertaken. The Ivrea Zone (N-Italy) exposes a lower continental crustal section in which a continuous metamorphic field gradient from amphibolite to granulite facies is documented. This field gradient is thought to reflect protracted heating during late Paleozoic times, with a probable high-T peak in the Permian. We present first results from a primarily textural study supported by U-Pb ages, Th/U ratios and Ti-in-Zrn thermometry. Four types of zircon were identified based on their overgrowth proportions and the preservation of detrital cores. Zircon grains were thus classified as Type1 - detrital grains with no overgrowth or very narrow rims (300 Ma) and appears to reflect an early dehydration phase. Rim2b has Permian ages (median 275 Ma), is by far the most common overgrowth type, found in a wide PT-range. Its development appears related to biotite breakdown. Rim3 is texturally indicative of magmatic zircon, occurs only in diatexites. Rim4 is the latest overgrowth and is locally found at all metamorphic grades. Textural features suggest late fluid-related recrystallization of existing zircon. At lowest grade (675±35°C, 6±2 kbar) zircons show type1 only, overgrowths are too thin to clearly identify the rim type. Further upgrade (~700°C, 7 kbar) type1 and type2 dominate. Type2 zircons show rim1, rim2a and occasionally rim4. At the Mu-out isograd (750±50°C, 8.2±1.4 kbar) most zircons are of type2, now with rim2b instead of 2a, in addition to rim1 and rim4. Near and in granulite facies (to 800°C, 8±2 kbar) mostly zircon type2 and type4 are present. While rim1 gets more narrow with increasing metamorphic grade, rim2b grows significantly thicker. Occasionally rim2a and rim4 occur. Close to the Bt-out isograd (~860°C, 9.2±1.7 kbar), mostly type3 and type4 are

A novel 2 T P-channel nano-crystal memory for low power/high speed embedded NVM applications

International Nuclear Information System (INIS)

Zhang Junyu; Wang Yong; Liu Jing; Zhang Manhong; Xu Zhongguang; Huo Zongliang; Liu Ming

2012-01-01

We introduce a novel 2 T P-channel nano-crystal memory structure for low power and high speed embedded non-volatile memory (NVM) applications. By using the band-to-band tunneling-induced hot-electron (BTBTIHE) injection scheme, both high-speed and low power programming can be achieved at the same time. Due to the use of a select transistor, the 'erased states' can be set to below 0 V, so that the periphery HV circuit (high-voltage generating and management) and read-out circuit can be simplified. Good memory cell performance has also been achieved, including a fast program/erase (P/E) speed (a 1.15 V memory window under 10 μs program pulse), an excellent data retention (only 20% charge loss for 10 years). The data shows that the device has strong potential for future embedded NVM applications. (semiconductor devices)

Effects of Baseline Selection on Magnetocardiography: P-Q and T-P Intervals

International Nuclear Information System (INIS)

Lim, Hyun Kyoon; Kwon, Hyuk Chan; Kim, Tae En; Lee, Yong Ho; Kim, Jin Mok; Kim, In Seon; Kim, Ki Woong; Park, Yong Ki

2007-01-01

The baseline selection is the first and important step to analyze magnetocardiography (MCG) parameters. There are no difficulties to select the baseline between P- and Q-wave peak (P-Q interval) of MCG wave recorded from healthy subjects because the P-Q intervals of the healthy subjects do not much vary. However, patients with ischemic heart disease often show an unstable P-Q interval which does not seem to be appropriate for the baseline. In this case, T-P interval is alternatively recommended for the baseline. However, there has been no study on the difference made by the baseline selection. In this study, we studied the effect of the different baseline selection. MCG data were analyzed from twenty healthy subjects and twenty one patients whose baselines were alternatively selected in the T-P interval for their inappropriate P-Q interval. Paired T-test was used to compare two set of data. Fifteen parameters derived from the R-wave peak, the T-wave peak, and the period, T max/3 ∼ T max were compared for the different baseline selection. As a result, most parameters did not show significant differences (p>0.05) except few parameters. Therefore, there will be no significant differences if anyone of two intervals were selected for the MCG baseline. However, for the consistent analysis, P-Q interval is strongly recommended for the baseline correction.

pH dependent green synthesis of gold nanoparticles by completely C6-carboxylated curdlan under high temperature and various pH conditions.

Science.gov (United States)

Qiu, Wen-Yi; Wang, Kai; Wang, Yao-Yao; Ding, Zhi-Chao; Wu, Li-Xia; Cai, Wu-Dan; Yan, Jing-Kun

2018-01-01

A C6-carboxylated curdlan (C6-Cc) obtained from 4-acetamido-TEMPO-mediated oxidation of curdlan was used both as a reducing and stabilizing agent for green synthesis of pH-responsive AuNPs, which was carried out by controlling the pH of the C6-Cc solution at a high temperature (100°C). C6-Cc presented a semi-flexible random coil chain in the aqueous medium at pH 5.5 and became more expanded and rigid in alkaline conditions (pH 7.1-12.0), though the primary chemical structure of C6-Cc was virtually unchanged with the pH variation. The AuNPs prepared with C6-Cc at various pHs were characterized by various instrumental measurements. The shapes and sizes of AuNPs were found to be strongly dependent on the pH of the C6-Cc solution. The C6-Cc-decorated AuNPs exhibited a more well-dispersed spherical morphology with smaller particle sizes under alkaline conditions (pH 7.1-12.0). Through this study, a facile, simple, and green method has been demonstrated for preparation of stimuli-sensitive AuNPs using biocompatible polyanionic polysaccharides. Copyright © 2017 Elsevier B.V. All rights reserved.

Investigation of the (p,p'), (p,d) and (p,t) reactions on some light Sn isotopes

International Nuclear Information System (INIS)

Blankert, P.J.

1979-01-01

The results are presented of the 112 Sn(p,p') 112 Sn reaction. Apart from the usual distorted-wave analysis the excitation of some states is described in the coupled-channels formalism. The results of the 112 Sn(p,d) 111 Sn and the 112 Sn(p,t) 110 Sn reactions are also reported. From the (p,d) reaction quasi-particle energies and occupation numbers are determined. Two-step DWBA calculations are performed for some states that are assumed to result from the coupling of a quasiparticle to the 2 + 1 or 3 - 1 state of the even core. In the gross structure above 3 MeV of excitation, pickup strength from deeply-bound hole states is observed. The (p,t) reaction provided spin and parity of a number of levels in 110 Sn. A two-step DWBA analysis of the excitation of the ground state and first excited 2 + state shows the importance of second-order processes. The combined results of the (p,t) reactions on 112 Sn, 114 Sn and 116 Sn are given with some emphasis on the systematic features. The derivation is given of some expressions for spectroscopic amplitudes necessary in the two-step DWBA calculations for the (p,t) reactions. For all reactions a comparison is made with other existing data and with the results of model calculations. (Auth.)

Idræt på hjernen

DEFF Research Database (Denmark)

Knudsen, Martin Elmbæk

Den 1. juni 2015 udkom læremidlet Idræt på hjernen, som har til formål at støtte elever og lærere i at bruge teori i den praktiske idrætsundervisning og - kort sagt - få idræt på hjernen. Læremidlet er rettet mod folkeskolens ældste klasser. Det er lektor Martin Elmbæk Knudsen fra Læreruddannelse...... ved UC Syddanmark, som står bag det nye materiale i samarbejde med KOSMOS. Læremidlet Idræt på hjernen præsenterer en ny måde at sammenkoble idrætsteori med idrætspraksis. Ambitionen med Idræt på hjernen er at give elever og lærere en håndsrækning til at inddrage teori i den praktiske...... grafiske tilrettelæggelse/design/layout og produktion samt de interaktive elementer, der gør det muligt at støtte materialet gennem brug af smart devices, QR-koder og web....

Study of High Mass Electron Pairs and High pT Phenomena

CERN Multimedia

2002-01-01

This experiment involves a modification of the apparatus used in R108, which extends the region of photon and electron detection to the entire azimuth, complementing the full azimuth charged particle detection already available. A five-fold increase in the acceptance for high mass e|+e|- pairs is thus achieved; the study of jets is also improved by extending the region of @g and @p|0 detection. An active converter consisting of lead glass and followed by a cathode strip read out MWPC is placed in front of each of the R108 lead glass arrays to improve @g/@p|0 discrimination. The modified apparatus is shown in the Figure. The specific physics aims of the experiment are: \\item 1) Search for high mass states decaying into e|+e|-. In a 3000-hour run the sensitivity is 2\\% of the @U cross-section for 10 detected events. \\item 2) Study of e|+e|- pair production above the @U mass. As well as the cross-section, the transverse momentum and rapidity distributions will be measured, providing a crucial test of QCD as appl...

An experimental investigation of Na incorporation in cordierite in low P/high T metapelites

Science.gov (United States)

Tropper, Peter; Wyhlidal, Stefan; Haefeker, Udo A.; Mirwald, Peter W.

2018-04-01

The aim of this experimental study was to investigate the incorporation of Na in cordierite in metapelites as a function of temperature and pressure using natural quartzphyllite rocks as starting materials. The experiments were performed in a hydrothermal apparatus as well as a piston-cylinder apparatus with two natural quartzphyllite samples, which represent the protolith rocks of the hornfelses from the Brixen Granite contact aureole near Franzensfeste. Sample W shows high muscovite contents (57 wt%) and only accessory plagioclase while sample SP5 has high plagioclase (16 wt%) and lower muscovite contents (20 vol%). The experiments were done dry at pressures of 0.15, 0.3 and 0.6 GPa in a temperature range of 550 °C to 780 °C. The Na content of the newly formed cordierites shows a systematic variation and decreases linearly with increasing temperatures and no influence of pressure and melting on the Na contents of cordierite was observed. The experiments also show that the difference in mineral assemblage considerably shifts the obtained Na contents of cordierite. The P-independent temperature correlations for both sets of experiments can be described with the linear relationships: T (°C) = (Na [apfu] - 0.4052)/(-0.000487); R2 = 0.96; (±20 °C, calibration W) and T (°C) = (Na [apfu] - 0.3671)/(-0.000383); R2 = 0.94; (±15 °C, calibration SP5). The difference between the two temperatures is large and the SP5 experiments yield temperatures that are up to 100 °C higher. This is not unexpected since theoretical phase relations in the system NMASH predict different Na contents depending on the buffering assemblage (plagioclase vs. paragonite). On the other hand these T differences could also reflect disequilibrium behaviour in the SP5 experiments. Detailed micro-Raman spectroscopic investigations reveal that cordierites from both experiments show disordered structures but the SP5 experiments show a much higher degree of Si-Al disorder and the elevated Na

Differences in high $p_{t}$ meson production between CERN SPS and RHIC heavy ion collisions

CERN Document Server

Papp, G; Barnafoldi, G G; Yi Zhang; Fái, G; Papp, Gabor; Levai, Peter; Barnafoldi, Gergely G.; Zhang, Yi; Fai, George

2001-01-01

In this talk we present a perturbative QCD improved parton model calculation for light meson production in high energy heavy ion collisions. In order to describe the experimental data properly, one needs to augment the standard pQCD model by the transverse momentum distribution of partons ("intrinsic k/sub T/"). Proton-nucleus data indicate the presence of nuclear shadowing and multi-scattering effects. Further corrections are needed in nucleus-nucleus collisions to explain the observed reduction of the cross section. We introduce the idea of proton dissociation and compare our calculations with the SPS and RHIC experimental data. (18 refs).

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

Directory of Open Access Journals (Sweden)

Rice Andrew P

2006-10-01

Full Text Available Abstract Background The latent reservoir of human immunodeficiency virus type 1 (HIV-1 in resting CD4+ T cells is a major obstacle to the clearance of infection by highly active antiretroviral therapy (HAART. Recent studies have focused on searches for adjuvant therapies to activate this reservoir under conditions of HAART. Prostratin, a non tumor-promoting phorbol ester, is a candidate for such a strategy. Prostratin has been shown to reactivate latent HIV-1 and Tat-mediated transactivation may play an important role in this process. We examined resting CD4+ T cells from healthy donors to determine if prostratin induces Cyclin T1/P-TEFb, a cellular kinase composed of Cyclin T1 and Cyclin-dependent kinase-9 (CDK9 that mediates Tat function. We also examined effects of prostratin on Cyclin T2a, an alternative regulatory subunit for CDK9, and 7SK snRNA and the HEXIM1 protein, two factors that associate with P-TEFb and repress its kinase activity. Results Prostratin up-regulated Cyclin T1 protein expression, modestly induced CDK9 protein expression, and did not affect Cyclin T2a protein expression. Although the kinase activity of CDK9 in vitro was up-regulated by prostratin, we observed a large increase in the association of 7SK snRNA and the HEXIM1 protein with CDK9. Using HIV-1 reporter viruses with and without a functional Tat protein, we found that prostratin stimulation of HIV-1 gene expression appears to require a functional Tat protein. Microarray analyses were performed and several genes related to HIV biology, including APOBEC3B, DEFA1, and S100 calcium-binding protein genes, were found to be regulated by prostratin. Conclusion Prostratin induces Cyclin T1 expression and P-TEFb function and this is likely to be involved in prostratin reactivation of latent HIV-1 proviruses. The large increase in association of 7SK and HEXIM1 with P-TEFb following prostratin treatment may reflect a requirement in CD4+ T cells for a precise balance between

P3T+: A Performance Estimator for Distributed and Parallel Programs

Directory of Open Access Journals (Sweden)

T. Fahringer

2000-01-01

Full Text Available Developing distributed and parallel programs on today's multiprocessor architectures is still a challenging task. Particular distressing is the lack of effective performance tools that support the programmer in evaluating changes in code, problem and machine sizes, and target architectures. In this paper we introduce P3T+ which is a performance estimator for mostly regular HPF (High Performance Fortran programs but partially covers also message passing programs (MPI. P3T+ is unique by modeling programs, compiler code transformations, and parallel and distributed architectures. It computes at compile-time a variety of performance parameters including work distribution, number of transfers, amount of data transferred, transfer times, computation times, and number of cache misses. Several novel technologies are employed to compute these parameters: loop iteration spaces, array access patterns, and data distributions are modeled by employing highly effective symbolic analysis. Communication is estimated by simulating the behavior of a communication library used by the underlying compiler. Computation times are predicted through pre-measured kernels on every target architecture of interest. We carefully model most critical architecture specific factors such as cache lines sizes, number of cache lines available, startup times, message transfer time per byte, etc. P3T+ has been implemented and is closely integrated with the Vienna High Performance Compiler (VFC to support programmers develop parallel and distributed applications. Experimental results for realistic kernel codes taken from real-world applications are presented to demonstrate both accuracy and usefulness of P3T+.

Identification of melatonin in Trichoderma spp. and detection of melatonin content under controlled-stress growth conditions from T. asperellum.

Science.gov (United States)

Liu, Tong; Zhao, Fengzhou; Liu, Zhen; Zuo, Yuhu; Hou, Jumei; Wang, Yanjie

2016-07-01

T. koningii, T. harzianum, T. asperellum, T. longibrachiatum, and T. viride were analyzed using liquid chromatography-tandem mass spectrometry to determine whether melatonin is present. Results showed that there were abundant amounts of endogenous melatonin in five Trichoderma species, but no melatonin was found in any of the culture filtrates. T. asperellum had the highest amount of melatonin (27.588 ± 0.326 μg g(-1) dry mass), followed by T. koningii, T. harzianum, T. longibrachiatum, and T. viride. The endogenous melatonin content of T. asperellum in controlled-stress growth conditions was also detected. The data showed that chemical stressors (CdCl2 , CuSO4 , and H2 O2 ) provoked an increase in endogenous melatonin levels. CdCl2 had the highest stimulatory effect on melatonin production, as the product reached reaching up to three times the melatonin content of the control. NaCl stimulated a decrease of melatonin. Acidic conditions (pH 3 and pH 5) as well as slightly alkaline conditions (pH 9) resulted in an increase in the melatonin content, whereas pH11 resulted in a significant decrease in the melatonin content, only 12.276 ± 0.205 μg g(-1) dry mass. The current study is first to report melatonin content and the change of melatonin content under different stress situations in Trichoderma spp. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Characterization of the human T cell response to rye grass pollen allergens Lol p 1 and Lol p 5.

Science.gov (United States)

Burton, M D; Papalia, L; Eusebius, N P; O'Hehir, R E; Rolland, J M

2002-12-01

Knowledge of dominant T cell epitopes of major allergens recognized by allergic individuals is required to improve efficacy and safety of allergen immunotherapy. Rye grass pollen (RGP) is the most important source of seasonal aeroallergens in temperate climates and Lol p 1 and Lol p 5 are the two major IgE-reactive allergens. This study aimed to characterize the T cell response to these allergens using a large panel of RGP-sensitive individuals. Short-term RGP-specific T cell lines (TCL) were generated from 38 RGP-sensitive subjects and stimulated with Lol p 1 and/or Lol p 5 allergens and synthetic 20-mer peptides. Proliferative responses were determined by 3H-thymidine uptake and IL-5 and IFN-gamma in culture supernatants analysed by ELISA. Of 17 subjects tested for reactivity to both allergens 16 (94%) responded to Lol p 1 and/or Lol p 5, establishing these as major T cell-reactive allergens. Sites of T cell reactivity were spread throughout the allergen molecules but regions of high reactivity were found. For Lol p 1 these spanned residues 19-38, 109-128, 154-173, 190-209, and for Lol p 5 37-56, 100-119, 145-164, 154-173, 190-209, 217-236 and 226-245. IL-5 and IFN-gamma were produced by T cells cultured with proliferation-inducing peptides. T cell responses to RGP major allergens have been extensively characterized, providing fundamental information for developing T cell-targeted immunotherapy for RGP allergy.

P T Symmetry and Singularity-Enhanced Sensing Based on Photoexcited Graphene Metasurfaces

Science.gov (United States)

Chen, Pai-Yen; Jung, Jeil

2016-06-01

We introduce here a parity-time-(P T ) symmetric system using an optically pumped, active graphene metasurface paired with a resistive metallic filament, realizing a unidirectional reflectionless propagation of terahertz (THz) waves. The amplified THz stimulated emission and tailored plasmon resonances in the graphene metasurface may achieve an equivalent negative-resistance converter at THz frequencies. We theoretically demonstrate that the combination of the spectral singularity in a P T -symmetric system and the chemical sensitivity of graphene may give rise to exotic scattering responses, strongly influenced by the presence of charged impurities in graphene at the spontaneous P T -symmetry-breaking point. This graphene-based P T -symmetric device may have broad relevance beyond the extraordinary manipulation of THz waves, as it may also open exciting prospects for detecting gas, chemical, and biological agents with high sensitivities.

Prospects for measuring the differential high p{sub T} b-jet cross section with the ATLAS detector

Energy Technology Data Exchange (ETDEWEB)

Grybel, Kai Karsten

2011-01-21

Currently, the Large Hadron Collider (LHC) at CERN in Geneva accelerates protons up to an energy of 3.5 TeV resulting in collisions of a center-of-mass energy of {radical}(s)=7 TeV. To study the production of b-quarks in proton-proton collisions is part of the physics program of the ATLAS experiment, which is one of the experiments at the LHC. The b-quarks produced in the hard scattering of the protons are measured as jets in the ATLAS detector. The aim of this PhD thesis is to study prospects of a differential p{sub T} b-jet cross section measurement in the jet p{sub T} range of p{sub Tjet} > 30 GeV. This study is based on simulated Monte Carlo (MC) data assuming a center-of-mass energy of {radical}(s)=10 TeV. The trigger selection is based on a combination of single jet triggers considering the different prescale factors of the different jet triggers. The MC data samples contain signal b-jets and background jets from other QCD physics processes in the proton-proton collision. In order to identify the b-jets and to reject background jets, b-tagging algorithms based on the on average longer lifetime of particles containing a b-quark compared to other hadrons, which decay before reaching the detector, are used. Since the b-tagging performance is not uniform over the jet p{sub T} region considered, different b-tagging efficiency scenarios are studied. The jet p{sub T} independent b-tagging efficiency scenarios of {epsilon}{sub Tag}=0.5 and {epsilon}{sub Tag}=0.6 as well as an optimized b-tagging efficiency scenario in order to minimize the statistical uncertainty of the measurement in each jet p{sub T} bin are presented. An unfolding algorithm is applied to the measured b-jet spectrum in order to correct for detector effects due to the measuring process. The expected systematic uncertainties for different jet p{sub T} regions are studied and an estimate for the evolvement of the statistical uncertainties as a function of the integrated luminosity is given. Once an

High speed machinability of the aerospace alloy AA7075 T6 under different cooling conditions

Science.gov (United States)

Imbrogno, Stano; Rinaldi, Sergio; Suarez, Asier Gurruchaga; Arrazola, Pedro J.; Umbrello, Domenico

2018-05-01

This paper describes the results of an experimental investigation aimed to st udy the machinability of AA7075 T6 (160 HV) for aerospace industry at high cutting speeds. The paper investigates the effects of different lubri-cooling strategies (cryogenic, M QL and dry) during high speed turning process on cutting forces, tool wear, chip morphology and cutting temperatures. The cutting speeds selected were 1000m/min, 1250m/min and 1500 m/min, while the feed rate values used were 0.1mm/rev and 0.3 mm/rev. The results of cryogenic and M QL application is compared with dry application. It was found that the cryogenic and M QL lubri-cooling techniques could represent a functional alternative to the common dry cutting application in order to implement a more effect ive high speed turning process. Higher cuttingparameters would be able to increase the productivity and reduce the production costs. The effects of the cutting parameters and on the variables object of study were investigated and the role of the different lubri-cooling conditions was assessed.

Size dependence of the thermo-electrodynamics states of composite high-T c superconductors and its effect on the current instability conditions

International Nuclear Information System (INIS)

Romanovskii, V.R.; Watanabe, K.

2006-01-01

The effect of transverse geometries of the slab of composite high-T c superconductors on their stable and unstable thermal and electrodynamics transient states in the incomplete and complete penetration modes during the current charging are discussed. The transient period when the electric field that is induced by the charged current becomes more homogeneous during the initial stage of the complete penetration mode in the sub-critical voltage range is studied. In the over-critical voltage range, the cross-section shape of the slab affects its stable and unstable temperature variation. As a result, the current instability condition is not identical for high-T c superconducting composite tapes that have the same cross-sectional area with various shapes of the cross-section. The condition depends on their thickness: the less thickness, the more stable the current distribution in the composite superconductors with the same cross-sectional area. This feature is a result of the unavoidable reduction of the current-carrying capacity of a high-T c superconducting composite by the temperature increase. This reduction is caused by the relevant temperature dependence of electrodynamics states of the composite. This temperature dependence happens even during a stable stage of the current charging. These mechanisms must be considered during experiments at which the critical or quenching currents are defined

InGaP DHBT for High Efficiency L-band T/R Module, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — A fully monolithically integrated L-band T/R module using InGaP/GaAs-based HBTs (heterojunction bipolar transistors) for both the transmit and receive functions is...

SYNTHESIS OF TETRA-p-PROPENYLTETRAESTERCALIX[4]ARENE AND TETRA-p-PROPENYLTETRACARBOXYLICACIDCALIX[4]ARENE FROM p-t-BUTYLPHENOL

Directory of Open Access Journals (Sweden)

Triana Kusumaningsih

2010-06-01

Full Text Available A research has been conducted to synthesize tetra-p-propenyltetraestercalix[4]arene and tetra-p-propenyltetracarboxylicacidcalix[4] arene using p-t-butylphenol as a starting material. The synthesis was carried out in following stages, i.e (1 synthesis of p-t-butylcalix[4]arene from p-t-butylphenol, (2 debutylation of p-t-butylcalix[4]arene, (3 tetraallilation of 25,26,27,28-tetrahydroxycalix[4]arene with NaH and allilbromida in dry tetrahydrofuran, (4 Claissen rearrangement of 25,26,27,28-tetrapropenyloxycalix[4]arene, (5 esterification of tetra-p-propenyltetrahydroxycalix[4]arene, (6 hydrolisis of tetra-p-propenyltetraestercalix[4]arene. The all structures of products were observed by means of melting point, FTIR, and 1H-NMR spectrometers. Tetra-p-propenyltetraestercalix[4]arene compound was obtained as yellow liquid product in 55.08% yield. Tetra-p-propenyltetracarboxylicacidcalix[4]arene compound was obtained as white solid product with the melting point 135-137 °C at decomposed and in 70.05% yield.   Keywords: calix[4]arene, Claissen rearrangement, esterification, hydrolisis

Waste management in future. Partitioning and transmutation (P and T)

International Nuclear Information System (INIS)

Calic, D.

2005-01-01

Current research and development (R and D) in radioactive waste management is mainly associated with the quantities and toxicity of high level waste and spent fuel. One of the solutions that already exists, but has not yet reached scientific and technological maturity, is the process of partitioning and transmutation (P and T). Partitioning is the selective separation of radiotoxic isotopes from reprocessing streams. After the successive partitioning has been done, the long-lived radionuclides are converted into shorter-lived or stable nuclides by process called transmutation. P and T can reduce the radiotoxic inventory of spent fuel by a factor of 100 to 1000 and can achieve the reduction of time needed to reach the radioactivity level of the uranium ore from 100,000 to 5000 years. To achieve this, the separation of plutonium, minor actinides and long-lived fission products has to be implemented as early as possible in the fuel cycle strategy. Currently, P and T is still at the research and development stage and it needs to be scaled up, before it can be introduced on an industrial scale, therefore the paper will present the current status of the development of P and T and plans for the future. (author)

The high exponent limit $p \\to \\infty$ for the one-dimensional nonlinear wave equation

OpenAIRE

Tao, Terence

2009-01-01

We investigate the behaviour of solutions $\\phi = \\phi^{(p)}$ to the one-dimensional nonlinear wave equation $-\\phi_{tt} + \\phi_{xx} = -|\\phi|^{p-1} \\phi$ with initial data $\\phi(0,x) = \\phi_0(x)$, $\\phi_t(0,x) = \\phi_1(x)$, in the high exponent limit $p \\to \\infty$ (holding $\\phi_0, \\phi_1$ fixed). We show that if the initial data $\\phi_0, \\phi_1$ are smooth with $\\phi_0$ taking values in $(-1,1)$ and obey a mild non-degeneracy condition, then $\\phi$ converges locally uniformly to a piecewis...

Time-of-flight positron emission tomography (T.O.F. P.E.T.)

International Nuclear Information System (INIS)

Allemand, R.

1984-10-01

A new important step has been made in the performances of the time-of-flight positron imaging for the two last years. It has been proved that a high spatial resolution can be obtained with the T.O.F. technique. It has also been shown that the overall sensitivity (taking into account the sensitivity gain and BaF2 detection characteristics) is quite close to the one of conventional methods. On the other hand, the basic advantages related to the high counting rate capability, the random coincidences rejection etc... of course remain. It is probably safe to assume that significant improvements can be expected if new technological efforts are invested. Unfortunately, P.E.T. is a complex and expensive tool which has been only used up to now in the research groups (about 50 centers in the world). The justification of new technical developments will be quite clear when this modality will be considered in the assessment of diseases and in clinical diagnostic applications

QCD phenomenology of the large P/sub T/ processes

International Nuclear Information System (INIS)

Stroynowski, R.

1979-11-01

Quantum Chromodynamics (QCD) provides a framework for the possible high-accuracy calculations of the large-p/sub T/ processes. The description of the large-transverse-momentum phenomena is introduced in terms of the parton model, and the modifications expected from QCD are described by using as an example single-particle distributions. The present status of available data (π, K, p, p-bar, eta, particle ratios, beam ratios, direct photons, nuclear target dependence), the evidence for jets, and the future prospects are reviewed. 80 references, 33 figures, 3 tables

Creep deformation behavior at long-term in P23/T23 steels

Energy Technology Data Exchange (ETDEWEB)

Sawada, K.; Tabuchi, M.; Kimura, K. [National Institute for Materials Science (Japan)

2008-07-01

Creep behavior of ASME P23/T23 steels was investigated and analyzed, focusing on creep strength degradation at long-term. Creep rupture strength at 625 C and 650 C dropped at long-term in both P23 and T23 steels. The stress exponent of minimum creep rate at 625 C and 650 C was 7.8-13 for higher stresses and 3.9-5.3 for lower stresses in the P23/T23 steels. The change of stress exponent with stress levels was consistent with the drop in creep rupture strength at long-term. The Monkman-Grant rule was confirmed in the range examined in P23 steel, while the data points deviated from the rule at long-term in the case of T23 steel. The creep ductility of P23 steel was high over a wide stress and temperature range. On the other hand, in T23 steel, creep ductility at 625 C and 650 C decreased as time to rupture increased. The change in ductility may cause the deviation from the Monkman-Grant rule. Fracture mode changed from transgranular to intergranular fracture in the long-term at 625 C and 650 C. (orig.)

Study on partitioning and transmutation (P and T) of high-level waste. Status of R and D. Final report

International Nuclear Information System (INIS)

Merk, Bruno; Glivici-Cotruta, Varvara

2014-01-01

The main project, where this sub project contributed to, has been structured into two modules: module A (funded by the federal ministry of economics, managed by KIT) and module B (funded by the federal ministry of education and research, managed by acatech). Partners in module A were DBE TECHNOLOGY GmbH, the Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Karlsruher Institute of Technology (KIT) and the Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen, in co-operation with the Forschungszentrum Juelich (FZJ). Modul B has been executed by the Zentrum fuer Interdisziplinaere Risiko- und Innovationsforschung der Universitaet Stuttgart (ZIRIUS). The overall coordination has been carried out by the Deutsche Akademie der Technikwissenschaften (acatech). The social implications have been evaluated in module B based on the analysis of the scientific and technological aspects in module A. Recommendations for communication and actions to be taken for the future positioning of P and T have been developed. In the project part, coordinated by HZDR - status of R and D - an overview on the whole topic P and T is given. The topic is opened by a short description of reactor systems possible for transmutation. In the following the R and D status of separation technologies, safety technology, accelerator technology, liquid metal technology, spallation target development, transmutation fuel and structural material development, as well as waste conditioning is described. The topic is completed by the specifics of transmutation systems, the basic physics and core designs, the reactor physics, the simulation tools and the development of Safety Approaches. Additionally, the status of existing irradiation facilities with fast neutron spectrum is described. Based on the current R and D status, the research and technology gaps in the topics: separation and conditioning, accelerator and spallation target, and reactor

Reconstruction of multiple P-T-t stages from retrogressed mafic rocks: Subduction versus collision in the Southern Brasília orogen (SE Brazil)

Science.gov (United States)

Tedeschi, Mahyra; Lanari, Pierre; Rubatto, Daniela; Pedrosa-Soares, Antônio; Hermann, Jörg; Dussin, Ivo; Pinheiro, Marco Aurélio P.; Bouvier, Anne-Sophie; Baumgartner, Lukas

2017-12-01

The identification of markers of subduction zones in orogenic belts requires the estimation of paleo-geothermal gradients through pressure-temperature-time (P-T-t) estimates in mafic rocks that potentially derive from former oceanic units once. However, such markers are rare in supracrustal sequences specially in deeply eroded and weathered Precambrian orogens, and reconstructing their metamorphic history is challenging because they are commonly retrogressed and only preserve a few mineral relicts of high-pressure metamorphism. Metamorphosed mafic rocks from Pouso Alegre region of the Neoproterozoic Southern Brasília Orogen outcrop as rare lenses within continental gneisses. They have previously been classified as retrograde eclogites, based on the presence of garnet and the characteristic symplectitic texture replacing omphacite. These rocks were interpreted to mark the suture zone between the Paranapanema and São Francisco cratons. To test the possible record of eclogitic conditions in the Pouso Alegre mafic rocks, samples including the surrounding felsic rocks have been investigated using quantitative compositional mapping, forward thermodynamic modeling and in-situ dating of accessory minerals to refine their P-T-t history. In the metamorphosed mafic rocks, the peak pressure assemblage of garnet and omphacite (Jd20, reconstructed composition) formed at 690 ± 35 °C and 13.5 ± 3.0 kbar, whereas local retrogression into symplectite or corona occurred at 595 ± 25 °C and 4.8 ± 1.5 kbar. The two reactions were coupled and thus took place at the same time. A zircon U-Pb age of 603 ± 7 Ma was obtained for metamorphic rims and linked to the retrogression stage. Monazite and metamorphic zircon U-Th-Pb ages for the surrounding rocks are at ca. 630 Ma and linked to peak pressure conditions similar to the one recorded by the mafic rocks. The low maximal pressure of 14 kbar and the high geothermal gradient do not necessarily support subduction process

No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used

DEFF Research Database (Denmark)

Ursing, Johan; Kofoed, Poul-Erik; Rodrigues, Amabelia

2009-01-01

increase of pfcrt 76T if the high doses of CQ commonly used are effective. METHODS AND FINDINGS: P. falciparum parasite density, age, sex, the proportion of chloroquine resistance associated haplotypes pfcrt 76T and P. falciparum multidrug resistance gene 1 86Y were assessed in 988 samples collected from...... to become the dominant P.falciparum type in Guinea-Bissau. This is most likely due to the efficacy of high-dose chloroquine as used in Guinea-Bissau, combined with a loss of fitness associated with pfcrt 76T.......BACKGROUND: Potentially chloroquine resistant P. falciparum, identified by the 76T haplotype in the chloroquine resistance transporter (pfcrt 76T), are highly prevalent throughout Africa. In Guinea-Bissau, normal and double dose chloroquine have respective efficacies of 34% and 78% against P...

Transfer phenomena in p-PbTe monocrystals grown under zero-g conditions

International Nuclear Information System (INIS)

Regel', L.L.; Rakhmatov, O.I.; Red'ko, N.A.; Parfen'ev, R.V.; AN SSSR, Leningrad. Fiziko-Tekhnicheskij Inst.)

1984-01-01

The purpose of the study is comparative investigation of low-temperature phenomena of charge and heat transfer in p-PbTe monocrystals grown by the method of oriented crystallization under zero-g conditions as well as under terrestrial conditions at identical technological regimes. Investigation of thermal conductivity a strong magnetic field permits to separate lattice and electron thermal conductivity components, the latter constituting 6% of total thermal conductivity. Therefore the predominant contribution to kappa(T) is made by the lattice thermal conductivity which turned to be close by value for both samples. This points to identical character of structural perfection of p-PbTe investigated monocrystals

T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response

Directory of Open Access Journals (Sweden)

Laura Aragoneses-Fenoll

2018-02-01

Full Text Available Class IA phosphatidylinositol 3-kinase (PI3K catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent immune responses is not clear. To address this problem, mice with p110α conditionally deleted in CD4+ and CD8+ T lymphocytes (p110α−/−ΔT were used. p110α−/−ΔT mice show normal development of T cell subsets, but slightly reduced numbers of CD4+ T cells in the spleen. “In vitro,” TCR/CD3 plus CD28 activation of naive CD4+ and CD8+ p110α−/−ΔT T cells showed enhanced effector function, particularly IFN-γ secretion, T-bet induction, and Akt, Erk, or P38 activation. Tfh derived from p110α−/−ΔT cells also have enhanced responses when compared to normal mice, and IL-2 expanded p110α−/−ΔT CD8+ T cells had enhanced levels of LAMP-1 and Granzyme B. By contrast, the expansion of p110α−/−ΔT iTreg cells was diminished. Also, p110α−/−ΔT mice had enhanced anti-keyhole limpet hemocyanin (KLH IFN-γ, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively. When compared to WT mice, p110α−/−ΔT mice inoculated with B16.F10 melanoma showed delayed tumor progression. The percentage of CD8+ T lymphocytes was higher and the percentage of Treg cells lower in the spleen of tumor-bearing p110α−/−ΔT mice. Also, IFN-γ production in tumor antigen-activated spleen cells was enhanced. Thus, PI3K p110α plays a significant role in antigen activation and differentiation of CD4+ and CD8+ T lymphocytes modulating antitumor immunity.

High burnup (41 - 61 GWd/tU) BWR fuel behavior under reactivity initiated accident conditions

Energy Technology Data Exchange (ETDEWEB)

Nakamura, Takehiko; Kusagaya, Kazuyuki; Yoshinaga, Makio; Uetsuka, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2001-12-01

High burnup boiling water reactor (BWR) fuel was pulse irradiated in the Nuclear Safety Research Reactor (NSRR) to investigate fuel behavior under cold startup reactivity initiated accident (RIA) conditions. Temperature, deformation, failure, and fission gas release behavior under the simulated RIA condition was studied in the tests. Fuel failure due to pellet-cladding mechanical interaction (PCMI) did not occur in the tests with typical domestic BWR fuel at burnups up to 56 GWd/tU, because they had limited cladding embrittlement due to hydrogen absorption of about 100 ppm or less. However, the cladding failure occurred in tests with fuel at a burnup of 61 GWd/tU, in which the peak hydrogen content in the cladding was above 150 ppm. This type of failure was observed for the first time in BWR fuels. The cladding failure occurred at fuel enthalpies of 260 to 360 J/g (62 to 86 cal/g), which were higher than the PCMI failure thresholds decided by the Japanese Nuclear Safety Commission. From post-test examinations of the failed fuel, it was found that the crack in the BWR cladding progressed in a manner different from the one in PWR cladding failed in earlier tests, owing to its more randomly oriented hydride distribution. Because of these differences, the BWR fuel was judged to have failed at hydrogen contents lower than those of the PWR fuel. Comparison of the test results with code calculations revealed that the PCMI failure was caused by thermal expansion of pellets, rather than by the fission gas expansion in the pellets. The gas expansion, however, was found to cause large cladding hoop deformation later after the cladding temperature escalated. (author)

HER-2 immunohistochemical expression as prognostic marker in high-grade T1 bladder cancer (T1G3

Directory of Open Access Journals (Sweden)

Luca Bongiovanni

2013-06-01

Full Text Available Objectives: To evaluate if the Human epidermal growth factor receptor 2 (HER-2 expression levels may be used as potential prognostic marker in high grade T1 blad- der cancer (T1G3 Methods: Specimens from transurethral resection of bladder tumour (TURBT of 103 patients with high-grade T1 bladder cancer were collected. This pathologic database was reviewed. Four-year follow-up data were matched with pathologic data. Eighty-three patients entered the study. HER-2 staining was performed. Patients were grouped for HER-2 status. Statistical analysis included Kaplan Meier survival analysis and Log-rank test. Results: Pathological review of TURBT specimens confirmed high-grade T1 transitional cell bladder cancer in all patients. Median follow-up was 12 months (mean 23,5; range 3-48. Twenty-one patients (25.4% present strong HER-2 expression (3+, 28 (33.7% moderate expression (2+, 26 (33.7% weak staining (1+ and 8 (9.6% negative expression (0. Thirty- one patients of 83 (37.4% had not evidence of disease, 41 (49.4% recurred, 11 (13.2% had a progression of disease. Forty-one patients had high grade T1 recurrence. Patients with HER-2 status 0 did not showed progression of disease. Patients with HER-2 status 3+, undergoing cys- tectomy because progression of disease, had a pathological stage > pT2 and a nodal involve- ment. Median Disease-Free Survival (DFS for all patients was 12 months (DFS probability (pDFS = 49.3%; 95% CI, -11.1/+10.1. Median DFS in HER-2 groups was 8 (pDFS 37.5%; 95% CI,-28.8/+29.9, 24 (pDFS 46.1%; 95% CI,-19.5/+17.5, 20 (pDFS 46.4%; 95% CI,-18.8/+16.9 and 10 months (pDFS 47.6%; 95% CI,-21.9/+19.1 respectively in HER-2 status 0,1+,2+,3+. Log-Rank test is not statistically significant (p = 0,39. Conclusions: This study showed that HER-2 expression does not represent a prognostic mark- er of recurrence/progression of disease in high-grade T1 bladder cancer.

A new fluorescent pH probe for extremely acidic conditions

Energy Technology Data Exchange (ETDEWEB)

Xu, Yu [School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Taishan College, Shandong University, Jinan 250100 (China); Jiang, Zheng [School of Life Science, Shandong University, Jinan 250100 (China); Taishan College, Shandong University, Jinan 250100 (China); Xiao, Yu [School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Taishan College, Shandong University, Jinan 250100 (China); Bi, Fu-Zhen [School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Miao, Jun-Ying, E-mail: miaojy@sdu.edu.cn [School of Life Science, Shandong University, Jinan 250100 (China); Zhao, Bao-Xiang, E-mail: bxzhao@sdu.edu.cn [School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China)

2014-04-01

A new coumarin-based fluorescent probe can detect highly acidic conditions in both solution and bacteria with high selectivity and sensitivity. Highlights: • A new fluorescence probe for very low pH was synthesized and characterized. • The probe can monitor pH in solution and bacteria. • The two-step protonation of N atoms of the probe leads to fluorescence quenching. Abstract: A novel turn-off fluorescent probe based on coumarin and imidazole moiety for extremely acidic conditions was designed and developed. The probe with pK_a = 2.1 is able to respond to very low pH value (below 3.5) with high sensitivity relying on fluorescence quenching at 460 nm in fluorescence spectra or the ratios of absorbance maximum at 380 nm to that at 450 nm in UV–vis spectra. It can quantitatively detect pH value based on equilibrium equation, pH = pK_a -log[(I_x - I_b)/(I_a - I_x)]. It had very short response time that was less than 1 min, good reversibility and nearly no interference from common metal ions. Moreover, using ¹H NMR analysis and theoretical calculation of molecular orbital, we verified that a two-step protonation process of two N atoms of the probe leaded to photoinduced electron transfer (PET), which was actually the mechanism of the fluorescence quenching phenomenon under strongly acidic conditions. Furthermore, the probe was also applied to imaging strong acidity in bacteria, E.coli and had good effect. This work illustrates that the new probe could be a practical and ideal pH indicator for strongly acidic conditions with good biological significance.

Evidence for core-coupled states in 87Y from a 89Y(p, t)87Y and 88Sr(p, t)86Sr comparison

International Nuclear Information System (INIS)

Oelrich, I.C.; Krien, K.; DelVecchio, R.M.; Naumann, R.A.

1976-01-01

The 89 Y(p, t) 87 Y and 88 Sr(p, t) 86 Sr reactions were studied at 42 MeV proton energy, using a quadrupole-dipole-dipole-dipole spectograph. Comparison of excitation energies, (p, t) cross section strengths and angular distribution shapes indicates that basis features of the core-coupling model apply to these nuclei. However, mixing of single particle states with the core-coupled states is evident. The (p, t) cross-section strength summed over the 87 Y multiplet is found with few exceptions to be nearly a constant multiple of the (p, t) strength of the associated 86 Sr state

Elucidating the pH-Dependent Structural Transition of T7 Bacteriophage Endolysin.

Science.gov (United States)

Sharma, Meenakshi; Kumar, Dinesh; Poluri, Krishna Mohan

2016-08-23

Bacteriophages are the most abundant and diverse biological entities on earth. Bacteriophage endolysins are unique peptidoglycan hydrolases and have huge potential as effective enzybiotics in various infectious models. T7 bacteriophage endolysin (T7L), also known as N-acetylmuramoyl-l-alanine amidase or T7 lysozyme, is a 17 kDa protein that lyses a range of Gram-negative bacteria by hydrolyzing the amide bond between N-acetylmuramoyl residues and the l-alanine of the peptidoglycan layer. Although the activity profiles of several of the T7 family members have been known for many years, the molecular basis for their pH-dependent differential activity is not clear. In this study, we explored the pH-induced structural, stability, and activity characteristics of T7L by applying a variety of biophysical techniques and protein nuclear magnetic resonance (NMR) spectroscopy. Our studies established a reversible structural transition of T7L below pH 6 and the formation of a partially denatured conformation at pH 3. This low-pH conformation is thermally stable and exposed its hydrophobic pockets. Further, NMR relaxation measurements and structural analysis unraveled that T7L is highly dynamic in its native state and a network of His residues are responsible for the observed pH-dependent conformational dynamics and transitions. As bacteriophage chimeric and engineered endolysins are being developed as novel therapeutics against multiple drug resistance pathogens, we believe that our results are of great help in designing these entities as broadband antimicrobial and/or antibacterial agents.

High p_T γ(3S) production at LHC energies

International Nuclear Information System (INIS)

Kumar, Vineet; Shukla, Prashant

2016-01-01

The quarkonia (QQ-bar) have provided useful tools for probing both perturbative and nonperturbative aspects of Quantum Chromodynamics (QCD). The quarkonia states are qualitatively different from most other hadrons since the velocity of the heavy constituents is small allowing a non-relativistic treatment of bound states. The NRQCD formalism is one of the most promising theoretical framework for the study of heavy quarkonium production. The study of the differential charmonia production cross sections in high energy p+p collisions is completed using NRQCD formalism

High-p$_{T}$ Tomography of d+Au and Au+Au at SPS, RHIC, and LHC

CERN Document Server

Vitev, I; Vitev, Ivan; Gyulassy, Miklos

2002-01-01

The interplay of nuclear effects on the p_T > 2 GeV inclusive hadron spectra in d+Au and Au+Au reactions at root(s) = 17, 200, 5500 GeV is compared to leading order perturbative QCD calculations for elementary p+p (p-bar+p) collisions. The competition between nuclear shadowing, Cronin effect, and jet energy loss due to medium-induced gluon radiation is predicted to lead to a striking energy dependence of the nuclear suppression/enhancement pattern in A+A reactions. We show that future d+Au data can used to disentangle the initial and final state effects.

CP odd observables for the t t-bar system produced at p p-bar and pp colliders

International Nuclear Information System (INIS)

Brandenburg, A.; Ma, J.P.

1992-01-01

Some CP odd observables are proposed to test CP invariance in the t t-bar system proceeded at p p-bar and pp colliders. As CP violation can appear both in the production and in the decays of the top quarks, it is important to separate the effects from each other by using different observables. These will be discussed and some comments on using the observables for pp colliders are also made. Numerical results for these observables are given together with their sensitivity to the new CP violating interactions. 17 refs, 1 fig

Construction of pRMES and pTMES plasmids to test their expression ability of Nanobodies via the efficient T7 promoter

International Nuclear Information System (INIS)

Masoud, H.; Quider, M.; Abbady, A.

2014-01-01

Nanobody technology is considered as a promising molecular biology technique performed by means of the genetic engineering of special type of antibodies, existing exclusively in Camelidea. It enables the obtaining of small proteins, referred to as Nanobodies, which are characterized by high stability and solubility, are able to link to their specific antigens. After production, the Nanobody genes are cloned within plasmids of protein expression in bacteria, allowing their stable and continuous production for research and applied purposes. This work aimed to design new plasmids for Nanobody genes cloning in order to ensure a strong expression via the efficient T7 promoter, thus enhancing the quantity of the produced Nanobodies. These plasmids were called pRMES and pTMES and their ability to express Nanobodies, NbBruc02 and Nb16M, was tested. The plasmid pTMES showed an enhanced production condition of this Nanobody. These new plasmids, by their variable characteristics, could represent efficient tools for general production of recombinant proteins, including Nanobodies (author).

Study on partitioning and transmutation (P and T) of high-level waste. Status of R and D. Final report; Studie zur Partitionierung und Transmutation (P and T) hochradioaktiver Abfaelle. Stand der Grundlagen- und technologischen Forschung. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Merk, Bruno; Glivici-Cotruta, Varvara

2014-07-01

The main project, where this sub project contributed to, has been structured into two modules: module A (funded by the federal ministry of economics, managed by KIT) and module B (funded by the federal ministry of education and research, managed by acatech). Partners in module A were DBE TECHNOLOGY GmbH, the Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Karlsruher Institute of Technology (KIT) and the Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen, in co-operation with the Forschungszentrum Juelich (FZJ). Modul B has been executed by the Zentrum fuer Interdisziplinaere Risiko- und Innovationsforschung der Universitaet Stuttgart (ZIRIUS). The overall coordination has been carried out by the Deutsche Akademie der Technikwissenschaften (acatech). The social implications have been evaluated in module B based on the analysis of the scientific and technological aspects in module A. Recommendations for communication and actions to be taken for the future positioning of P and T have been developed. In the project part, coordinated by HZDR - status of R and D - an overview on the whole topic P and T is given. The topic is opened by a short description of reactor systems possible for transmutation. In the following the R and D status of separation technologies, safety technology, accelerator technology, liquid metal technology, spallation target development, transmutation fuel and structural material development, as well as waste conditioning is described. The topic is completed by the specifics of transmutation systems, the basic physics and core designs, the reactor physics, the simulation tools and the development of Safety Approaches. Additionally, the status of existing irradiation facilities with fast neutron spectrum is described. Based on the current R and D status, the research and technology gaps in the topics: separation and conditioning, accelerator and spallation target, and reactor

The semi-brittle to ductile transition in peridotite on oceanic faults: mechanisms and P-T condition

Science.gov (United States)

Prigent, C.; Warren, J. M.; Kohli, A. H.; Teyssier, C. P.

2017-12-01

Experimental and geological-petrological studies suggest that the transition from brittle faulting to ductile flow of olivine, i.e. from seismic to aseismic behavior of mantle rocks (peridotites), occurs close to 600°C. However, recent seismological studies on oceanic transform faults (TFs) and ridges have documented earthquakes to temperatures (T) up to 700-800°C. In this study, we carried out a petrological, microstructural and geochemical analysis of natural samples of peridotites dredged at 3 different oceanic TFs of the Southwest Indian Ridge: Shaka, Prince Edward and Atlantis II. We selected samples displaying variable amounts of ductile deformation (from porphyroclastic tectonites to ultramylonites) prior to serpentinization in order to characterize their relatively high-T mechanical behavior. We find that the most deformed samples record cycles of ductile and brittle deformation. Peridotite ductile flow is characterized by drastic grain size reduction and the development of (ultra)mylonitic shear zones. In these zones, a switch in olivine deformation mechanism from dislocation creep to grain-size sensitive creep is associated with dissolution/precipitation processes. Brittle deformation of these samples is evidenced by the presence of (at least centimetric) transgranular and intragranular fractures that fragment coarser grained minerals. Both kinds of fractures are filled with the same phase assemblage as in the ultramylonitic bands: olivine + amphibole ± orthopyroxene ± Al-phase (plagioclase and/or spinel) ± sulfides. The presence of amphibole indicates that this semi-brittle deformation was assisted by hydrous fluids and its composition (e.g. high concentration of chlorine) suggests that the fluids have most likely a hydrothermal origin. We interpret these fractures to have formed under fluid-assisted conditions, recording paleo-seismic activity that alternated with periods of relatively slow interseismic ductile flow. The presence of Mg

Closed expressions for $\\int_{0}^{1} t^{-1} log^{n-1}t log^{p}(1 - t) dt$

CERN Document Server

Kölbig, Kurt Siegfried

1982-01-01

Closed expressions for the integral integral /sub 0//sup 1/ t/sup -1/ log/sup n-1/t log/sup p/(1-t)dt, whose general form is given elsewhere, are listed for n=1(1)9, p=1(1)9. A formula is derived which allows an easy evaluation of these expressions by formula manipulation on a computer. The majority of the above expressions are given in a microfiche supplement to the paper.

Charged particle spectra in π-p,π-d and π-C interactions at 38 GeV/c with single-particle high pT trigger

International Nuclear Information System (INIS)

Boos, E.G.; Mosienko, A.M.; Baerwolff, H.

1987-01-01

Angular momentum distributions of charged secondaries from 38 GeV/c π - p, π - d and π - C interactions triggered on at least one particle with p T >or approx. 1 GeV/c at an 90 deg πN c.m.s angle have been investigated with the spectrometer RISK (a streamer chamber placed into a magnet). Transversal momentum spectra of secondaries in the 0.4-2.4 GeV/c p T -range including triggering particles are quite well fitted with the exponential function for all nuclei studied and for particles of different charges. The azimuthal angle distribution of secondaries (an angle relative to the p T -tilde of the triggering particle) for both trigger-like and trigger-unlike charges is anisotropic, preferring the direction away from the triggering particle. The mean charge distribution of associated particles is discussed. A small fraction of triggering particles is due to neutral strange particle decays. Many Λ 0 -hyperons were detected among those neutral strange triggers

Application of the risk-informed methodology for APR1400 P-T limits curve

Energy Technology Data Exchange (ETDEWEB)

Kim, K.; Namgung, I. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2014-07-01

A reactor pressure vessel (RPV) in a nuclear power plant has operational limits of pressure and temperature to prevent a potential drastic propagation of cracks due to brittle fracture. We call it a pressure-temperature limits curve (P-T limits curve). Appendix G of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, provides deterministic procedures to develop the P-T limits curve for the reactor pressure vessel. Recently, an alternative risk-informed methodology has been added in the ASME Code. Risk-informed means that we can consider insights from a probabilistic risk assessment by using this methodology. This alternative methodology provides a simple procedure to develop risk-informed P-T limits for heat up, cool down, and hydrostatic test events. The risk-informed P-T limits curve is known to provide more operational flexibility, particularly for reactor pressure vessels with relatively high irradiation levels and radiation sensitive materials. In this paper, we developed both the deterministic and a risk-informed P-T limits curve for an APR1400 reactor using Appendix G of the ASME Code, Section XI and compare the results in terms of additional operational margin. (author)

The pρT behaviour of the lactate family

International Nuclear Information System (INIS)

Lomba, Laura; Pino, M. Rosa; Lafuente, Carlos; Lopez, M. Carmen; Giner, Beatriz

2013-01-01

Highlights: ► PrhoT behaviour of three lactates are reported. ► The experimental results have been compared with the available literature data. ► TRIDENT model has been used to correlate experimental data of the compounds. ► Derived properties have been calculated from densities using Tait equation. -- Abstract: The densities of methyl lactate, ethyl lactate and butyl lactate have been measured using a high-pressure, high-temperature vibrating tube densimeter system over a temperature range from T = (283.15 to 338.15) K and a pressure range from p = (0.1 to 60.0) MPa. The experimental densities have been satisfactorily correlated with temperature and pressure using the TRIDEN equation. Finally, from the experimental densities, properties such as isobaric expansibility and isothermal compressibility have been calculated

Energy conditions in f(G,T) gravity

Energy Technology Data Exchange (ETDEWEB)

Sharif, M.; Ikram, Ayesha [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

2016-11-15

The aim of this paper is to introduce a new modified gravity theory named f(G,T) gravity (G and T are the Gauss-Bonnet invariant and trace of the energy-momentum tensor, respectively) and investigate energy conditions for two reconstructed models in the context of FRW universe. We formulate general field equations, divergence of energy-momentum tensor, equation of motion for test particles as well as corresponding energy conditions. The massive test particles follow non-geodesic lines of geometry due to the presence of an extra force. We express the energy conditions in terms of cosmological parameters like the deceleration, jerk, and snap parameters. The reconstruction technique is applied to this theory using de Sitter and power-law cosmological solutions. We analyze the energy bounds and obtain feasible constraints on the free parameters. (orig.)

Separation of minimum and higher twist in photoproduction of high-pT mesons

International Nuclear Information System (INIS)

Apsimon, R.J.; Flower, P.S.; Hallewell, G.; Morris, J.A.G.; Morris, J.V.; Paterson, C.N.; Sharp, P.H.; Atkinson, M.; Brook, N.; Coyle, P.; Dickinson, B.; Donnachie, A.; Doyle, A.T.; Ellison, R.J.; Foster, J.M.; Hughes-Jones, R.E.; Ibbotson, M.; Kolya, S.D.; Lafferty, G.D.; McCann, H.; McManus, C.; Mercer, D.; Ottewell, P.J.; Reid, D.; Thompson, R.J.; Waterhouse, J.; Barberis, D.; Davenport, M.; Eades, J.; Ingelman, G.; McClatchey, R.; Brodbeck, T.J.; Charity, T.; Clegg, A.B.; Henderson, R.C.W.; Hickman, M.T.; Keemer, N.R.; Newton, D.; O'Connor, A.; Wilson, G.W.; Danaher, S.; Galbraith, W.; Thacker, N.A.; Thompson, L.; Diekmann, B.; Gapp, C.; Gebert, F.; Heinloth, K.; Hoeger, K.C.; Holzkamp, A.; Holzkamp, S.; Jakob, H.P.; Joseph, D.; Kingler, J.; Koersgen, G.; Oedingen, R.; Paul, E.; Rotscheidt, H.; Soeldner-Rembold, S.; Weigend, A.S.

1991-01-01

Photo- and hadroproduction data in the beam energy range 65-175 GeV have been studied with a view to isolating higher-twist processes in photoproduction from other point-like and hadron-like contributions. With selection of charged tracks having p T >2 GeV/c and 0.28 F <0.84 indications of a higher twist contribution have been found at a level that is consistent with QCD expectations. (orig.)

Hard and soft processes in small p/sub T/ inclusive reactions

Energy Technology Data Exchange (ETDEWEB)

Kanki, T [Osaka Univ., Toyonaka (Japan). Coll. of General Education; Okamoto, Y; Ryang, S

1977-12-01

Small p/sub T/ inclusive single-hadron spectra in high-energy hadron-hadron collisions are discussed in view of the two-component structure; each component corresponds to the contribution from the incoherent hard process or the coherent soft process among the partons. The clustered parton model, where each constituent quark is considered a cluster of the partons, gives the theoretical basis and certain regularities for both components. The various experimental spectra are shown to be well described by the two-component formula with these regularities. It is also argued that the CIM approach to small p sub(T) shows some disagreement with the data.

Low $p_T$ Hadronic Physics with CMS

CERN Document Server

AUTHOR|(CDS)2072044

2007-01-01

The pixel detector of CMS can be used to reconstruct very low pT charged particles down to about 0.1 GeV/c. This can be achieved with good efficiency, resolution and negligible fake rate for elementary collisions. In case of central PbPb the fake rate can be kept low for pT>0.4 GeV/c. In addition, the detector can be employed for identification of neutral hadrons (V0s) and converted photons.

Low pT Hadronic Physics with CMS

CERN Document Server

Sikler, Ferenc

2007-01-01

The pixel detector of CMS can be used to reconstruct very low pT charged particles down to about 0.1 GeV/c. This can be achieved with good efficiency, resolution and negligible fake rate for elementary collisions. In case of central PbPb the fake rate can be kept low for pT>0.4 GeV/c. In addition, the detector can be employed for identification of neutral hadrons (V0s) and converted photons.

Hydrolysis of R7T7 nuclear waste glass in dilute media: mechanisms and rate as a function of pH

International Nuclear Information System (INIS)

Advocat, T.; Vernaz, E.; Charpentier, H.; Crovisier, J.L.; Ehret, G.

1990-01-01

R7T7 nuclear waste glass dissolution in highly dilute aqueous media under static conditions at 90 0 C occurs according to two different mechanisms depending on the solution acidity. In acid media (pH 4.8 and 5.5), preferential extraction of glass network modifiers results in the formation of an alkali metal-depleted surface region on which amorphous and crystallized (phosphate) compounds rich in transition elements precipitate. Steady-state dissolution conditions are not reached, as attested by variable normalized Si, B and Na mass losses. Glass dissolution is stoichiometric in basic media (pH 7 to 10): the strong bonds of the silicated network are broken at a rate that increases with the pH: the glass dissolution rate increases by a factor of 15 between pH 7 and 10. Under these conditions, alteration products at the glass/solution interface do not constitute a short-term kinetic barrier against the release of the major glass components

Endoscopic extraperitoneal radical prostatectomy after radical resection of pT1-pT2 rectal cancer: a report of thirty cases.

Science.gov (United States)

Liu, Zhuo; Li, Dechuan; Chen, Yinbo

2017-01-01

Endoscopic extraperitoneal radical prostatectomy (EERPE) has gained popularity for the treatment of localized prostate cancer. However, prior complex lower abdominal or pelvic surgery can complicate subsequent EERPE. To date, there have been few reports on patients who underwent EERPE after radical resection of pT1-pT2 rectal cancer. To present our experience with EERPE in patients after radical resection of pT1-pT2 rectal carcinoma and introduce a simple and effective way to create an extraperitoneal working space. Thirty patients after radical resection of pT1-pT2 rectal carcinoma were treated with EERPE for biopsy-proven localized prostate cancer. Operation time, estimated blood loss, conversion to open surgery rate, transfusion rate and transurethral catheter time were recorded. Meanwhile, functional outcome (continence and potency) and oncological outcome were reviewed. The average operative time was 168 min. Mean blood loss was 195 ml. There was no need for conversion to open surgery or transfusion. The catheter was removed on postoperative day (POD) 7.8. After a mean follow-up time of 53.1 months, 3 patients had a prostate-specific antigen level relapse over 0.1 ng/ml. At the follow-up time, 26 patients were completely continent, and 4 needed 1-2 pads/day. Of the 6 patients who underwent neurovascular bundle preservation, none have experienced return of erections at the last follow-up time. Endoscopic extraperitoneal radical prostatectomy after radical resection of rectal carcinoma appears promising, with feasibility in experienced hands. The operative data, postoperative urinary incontinence and oncological outcomes appear encouraging, but the rate of erectile dysfunction seems to be disappointing.

Reactor Pressure Vessel P-T Limit Curve Round Robin

Energy Technology Data Exchange (ETDEWEB)

Jang, C.H.; Moon, H.R.; Jeong, I.S. [Korea Electric Power Research Institute, Taejon (Korea)

2002-07-01

This report is the summary of the analysis results for the P-T Limit Curve construction which have been subjected to the round robin analysis. The purpose of the round robin is to compare the procedure and method used in various organizations to construct P-T limit curve to prevent brittle fracture of reactor pressure vessel of nuclear power plants. Each Participant used its own approach to construct the P-T limit curve and submitted the results, By analyzing the results, the reference procedure for the P-T limit curve could be established. This report include the results of the comparison of the procedure and method used by the participants, and sensitivity study of the key parameters. (author) 23 refs, 88 figs, 17 tabs.

t anti-t production cross section measurement using soft electron tagging in p anti-p collisions at √s = 1.96-TeV

Energy Technology Data Exchange (ETDEWEB)

Chou, John Paul [Harvard Univ., Cambridge, MA (United States)

2008-09-01

We measure the production cross section of t$\\bar{t}$ events in p$\\bar{p}$ collisions at √s = 1.96 TeV. The data was collected by the CDF experiment in Run 2 of the Tevatron accelerator at the Fermi National Accelerator Laboratory between 2002 and 2007. 1.7 fb^-1 of data was recorded during this time period. We reconstruct t$\\bar{t}$ events in the lepton+jets channel, whereby one W boson - resulting from the decay of the top quark pairs - decays leptonically and the other hadronically. The dominant background to this process is the production of W bosons in association with multiple jets. To distinguish t$\\bar{t}$ from background, we identify soft electrons from the semileptonic decay of heavy flavor jets produced in t$\\bar{t}$ events. We measure a cross section of σ_$\\bar{p}$ = 7.8 ± 2.4(stat) ± 1.6(syst) ± 0.5(lumi).

Spin correlation in t anti t production from p anti p collisions at √s = 1.8 TeV

International Nuclear Information System (INIS)

Suyong Choi

2000-01-01

The Standard Model predicts that the lifetime of the top quark is shorter than the typical time scale at which hadronization process occurs, and the spin information at its production is preserved. Spin correlation of the t anti t system from p anti p collisions at the Tevatron is analyzed using 6 events in the dilepton channels collected using the D0 detector. Spin correlation factor of κ > minus 0.25 at 68% CL is obtained from the data

Search for Wh Production Using High-P_T Isolated Like-Sign Dilepton Events in 1.96-TeV Proton-Antiproton Collisions

Energy Technology Data Exchange (ETDEWEB)

Wakisaka, Takayuki [Osaka City Univ. (Japan)

2009-04-01

The thesis describes search for the neutral Higgs production associated with the W boson using high-P_T isolated like-sign (LS) dilepton events in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV.

Experimental measurements of the solubilities of selected long-lived fission products, activation products and actinide daughters under high pH conditions

International Nuclear Information System (INIS)

Pilkington, N.J.; Shadbolt, P.J.; Wilkins, J.D.

1988-05-01

Solubility measurements of several elements have been attempted under high pH and oxic conditions in a range of concrete leachates. The elements investigated were niobium, tin, selenium, lead and thorium. (author)

Contrasting feature in the repopulation of host-type T cells in the spleens of F1----P and P----F1 radiation bone marrow chimeras

International Nuclear Information System (INIS)

Hirokawa, K.; Sado, T.; Kubo, S.; Kamisaku, H.; Utsuyama, M.

1986-01-01

The regeneration and persistence of host- and donor-derived T cells were examined in the thymus as well as the spleen of mouse radiation bone marrow chimeras of two semiallogeneic combinations (F1----P, P----F1) with different Thy-1 markers on T cells of donor and host origins. An unexpectedly large number of host-type T cells were recovered from the spleens of F1----P chimeras, amounting to as high as 45 and 25% of total T cells at 6 and 14 weeks after bone marrow transplantation (BMT), respectively. To the contrary, the residual host-type T cells in the spleens of P----F1 chimeras disappeared quickly, resulting in less than 0.1% of total T cells at 6 weeks after BMT. It was also revealed that the number of host-type T cells in the spleens of F1----P chimeras decreased in proportion to increase of radiation dose given to the recipients

Specialities of the differentiation conditions for the memory cells - either initial or enriched secondary cytotoxic T lymphocyte precursors (pCTL-2) specific to the MHC molecule class 1

International Nuclear Information System (INIS)

Brondz, B.D.; Osipova, T.V.; Aptikaeva, G.F.; Kronin, V.V.

1989-01-01

The in vivo induced pCTL-2 with phenotype L3T4 - Lyt2 + , specific to the H-2K b molecule, turn into effector CTLs during 4 days in the mixed lymphocyte culture (with heat-treated donor stimulators) much more efficiency when donor and recipient are different from one another not only in MHC class 1 (anti-BIO, MBR BIO.AKM) but in 1+2 (K b +1 b ) anti-C57BL/6 BIAD2(R1O1). The initial pCTL-2 differentiation in enhanced as a result of synergistic effect between the K b alloantigen and rIL2. The anti-K b pCTL-2, being separated from helper T cells by means of absorption onto the macrophage donor monolayer and elution from it, give rise to pronounced differentiation in simplified conditions, irrespective of the stimulator presence and without external rIL2. It is supposed that these phenomena are roused to secrection of the CTL differentiation factor by the eluted pCTL-2 themselves, and besides, rIL2 may promote for secretion of this factor additionally

High-$T_c$ superconductivity by phase cloning

CERN Document Server

Ilieva, N; Ilieva, Nevena; Thirring, Walter

2007-01-01

We consider a BCS-type model in the spin formalism and argue that the structure of the interaction provides a mechanism for control over directions of the spin $\\vect S$ other than $S_z$, which is being controlled via the conventional chemical potential. We also find the conditions for the appearance of a high-$T_c$ superconducting phase.

Tæt på relationen

DEFF Research Database (Denmark)

Siersted, Mette

1998-01-01

sættes på begreb : teori og metode / Janne Hedegaard Hansen og Bent Madsen ; Velfærdsstaten i det moderne. Bent Madsen: Refleksion og fortolkning - i lyset af George Herbert Meads symbolske interaktionisme ; At beskrive praksis : fra empiri til praksisportræt. Med praksis som kilde til kundskab : otte...

Evaluation of the effect of Ni-P coating on the corrosion resistance of the aluminium 7075 T6 alloy

OpenAIRE

Gil, L.; Jiménez, L.; Castro, A. C.; Staia, M. H.; Puchi-Cabrera, E. S.

2008-01-01

The aluminum alloy 7075-T6 is a structural alloy widely used for aeronautical applications due to its high relationship between mechanical resistance and weight. Depending upon the environmental conditions, many types of corrosion mechanisms such as intergranular, exfoliation, have been found to occur in aircraft structural aluminum alloys. A significant advance in order to improve the behavior of this alloy is related to the application of the autocatalytic Ni-P coating which confers an exce...

Recording visual evoked potentials and auditory evoked P300 at 9.4T static magnetic field.

Science.gov (United States)

Arrubla, Jorge; Neuner, Irene; Hahn, David; Boers, Frank; Shah, N Jon

2013-01-01

Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has shown a number of advantages that make this multimodal technique superior to fMRI alone. The feasibility of recording EEG at ultra-high static magnetic field up to 9.4 T was recently demonstrated and promises to be implemented soon in fMRI studies at ultra high magnetic fields. Recording visual evoked potentials are expected to be amongst the most simple for simultaneous EEG/fMRI at ultra-high magnetic field due to the easy assessment of the visual cortex. Auditory evoked P300 measurements are of interest since it is believed that they represent the earliest stage of cognitive processing. In this study, we investigate the feasibility of recording visual evoked potentials and auditory evoked P300 in a 9.4 T static magnetic field. For this purpose, EEG data were recorded from 26 healthy volunteers inside a 9.4 T MR scanner using a 32-channel MR compatible EEG system. Visual stimulation and auditory oddball paradigm were presented in order to elicit evoked related potentials (ERP). Recordings made outside the scanner were performed using the same stimuli and EEG system for comparison purposes. We were able to retrieve visual P100 and auditory P300 evoked potentials at 9.4 T static magnetic field after correction of the ballistocardiogram artefact using independent component analysis. The latencies of the ERPs recorded at 9.4 T were not different from those recorded at 0 T. The amplitudes of ERPs were higher at 9.4 T when compared to recordings at 0 T. Nevertheless, it seems that the increased amplitudes of the ERPs are due to the effect of the ultra-high field on the EEG recording system rather than alteration in the intrinsic processes that generate the electrophysiological responses.

Measurement of the t(bar t), WW and Z → ττ Production Cross Sections in p(bar p) collisions at √s = 1.96 TeV

International Nuclear Information System (INIS)

Carron Montero, Sebastian

2006-01-01

In this thesis we present a new technique to analyze events containing two highly energetic leptons, as a probe of the Standard Model. The philosophy is to consider the data in a more global way, as opposed to the more traditional process dependent approach of extracting a given signal over the expected backgrounds by using various kinematical requirements. We use our global technique to simultaneously measure the cross sections of the main Standard Model processes; the t(bar t), WW and Z → ττ production from p(bar p) collisions at √s = 1.96 TeV in the CDF detector at Fermilab. We select events by requiring they contain two highly energetic leptons (eμ, ee, or μμ), and make no other kinematic requirements, except for the ee and μμ channels. We then use a likelihood fit of the data in the two-dimensional phase space defined by the missing transverse energy (E T ) and the number of jets in the event (N jet ), to the expected Standard Model distributions, to simultaneously extract the production cross-sections of the main process contributing to our dilepton sample

Eclogites and garnet clinopyroxenites in the Anrakhai complex, Central Asian Orogenic Belt, Southern Kazakhstan: P-T evolution, protoliths and some geodynamic implications

Science.gov (United States)

Pilitsyna, Anfisa V.; Tretyakov, Andrey A.; Degtyarev, Kirill E.; Cuthbert, Simon J.; Batanova, Valentina G.; Kovalchuk, Elena V.

2018-03-01

The Anrakhai Metamorphic Complex (AMC), located in the SE part of the Chu-Ili Mountains of Southern Kazakhstan in the western part of Central Asian Orogenic Belt, exhibits occurrences of HP metamorphic rocks in the form of eclogites and garnet clinopyroxenites with peak metamorphic conditions of 750-850° and 15-19 kbar estimated with both conventional geothermobarometric methods and phase diagram modeling. P-T estimates as well as intimate field relations evidently imply a common metamorphic history for eclogites and garnet clinopyroxenites of the AMC. These high-pressure, medium temperature eclogite facies P-T conditions are indicative of a collision or subduction tectonic setting. Major and trace element geochemistry suggests that they probably had a common magmatic origin as part of a suite of differentiated tholeiitic intrusions. Furthermore, distinctive mineral and chemical compositions of these eclogites and garnet clinopyroxenites correspond to the Fe-Ti type of ultramafic rocks suggesting that they may have been derivatives of intraplate tholeiitic melts, introduced into continental crust before HP metamorphism.

High-pressure synthesis and characterization of the effective pseudospin S =1 /2 XY pyrochlores R2P t2O7 (R =Er ,Yb )

Science.gov (United States)

Cai, Y. Q.; Cui, Q.; Li, X.; Dun, Z. L.; Ma, J.; dela Cruz, C.; Jiao, Y. Y.; Liao, J.; Sun, P. J.; Li, Y. Q.; Zhou, J. S.; Goodenough, J. B.; Zhou, H. D.; Cheng, J.-G.

2016-01-01

We report on the high-pressure syntheses and detailed characterizations of two effective pseudospin S =1 /2 XY pyrochlores E r2P t2O7 and Y b2P t2O7 via x-ray/neutron powder diffraction, dc and ac magnetic susceptibility, and specific-heat measurements down to 70 mK. We found that both compounds undergo long-range magnetic transitions at TN ,C≈0.3 K , which are ascribed to an antiferromagnetic- and ferromagnetic-type order for E r2P t2O7 and Y b2P t2O7 , respectively, based on the field dependence of their transition temperatures as well as the systematic comparisons with other similar pyrochlores R2B2O7 (R =Er ,Yb ;B =Sn ,Ti ,Ge ). The observed TN of E r2P t2O7 is much lower than that expected from the relationship of TN versus the ionic radius of B4 + derived from the series of E r2B2O7 , while the TC of Y b2P t2O7 is the highest among the series of ferromagnetic compounds Y b2B2O7 (B =Sn ,Pt ,Ti ). Given the monotonic variation of the lattice constant as a function of the B -cation size across these two series of R2B2O7 (R =Er ,Yb ), the observed anomalous values of TN ,C in the Pt-based XY pyrochlores imply that another important factor beyond the nearest-neighbor R -R distance is playing a role. In light of the anisotropic exchange interactions Jex={Jz z,J±,J±±,Jz ± } for the S =1 /2 XY pyrochlores, we have rationalized these observations by considering a weakened (enhanced) antiferromagnetic planar J± (ferromagnetic Ising-like Jz z) due to strong Pt 5 d -O 2 p hybridization within the plane perpendicular to the local [111] direction.

Measurement of the t anti-t production cross section in p anti-p collisions at √s = 1.96-TeV

Energy Technology Data Exchange (ETDEWEB)

Ray, Heather Lynn [Univ. of Michigan, Ann Arbor, MI (United States)

2004-01-01

The direct observation of the top quark was first achieved at the Tevatron proton anti-proton collider at Fermilab. This discovery completed the third generation quark sector where the top quark is expected to accompany the bottom quark in the weak isospin doublet. This dissertation discusses the experimental verification of the production cross section as predicted by the Standard Model. A measurement of the t$\\bar{t}$ production cross section using 107.9 pb^-1 of p$\\bar{p}$ collisions at √s = 1.96 TeV collected with the Collider Detector at Fermilab between March of 2003 and June of 2003 is presented. The measurement focuses on the t$\\bar{t}$ production in the ''lepton plus jets'' final state in which one of the W bosons from the t$\\bar{t}$ decay subsequently decays leptonically to an electron or a muon, and the other decays hadronically. The B-tagging technique which utilizes the precision silicon detector tracking is used to enhance the signal for t$\\bar{t}$ events relative to the background through identification of the bottom quark from its measurable lifetime. The t$\\bar{t}$ production cross section is measured to be σ_t$\\bar{t}$ = 4.5 ± 1.4(stat) ± 0.8(sys) pb.

Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

Science.gov (United States)

Vargas-Duarte, J. J.; Lozano-Márquez, H.; Grajales-Lombana, H. A.; Manrique-Perdomo, C.; Martínez-Bello, D. A.; Saegerman, C.; Raes, M.; Kirschvink, N.

2015-01-01

This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1) was applied at late pregnancy (T 1, n = 15) or 48 hours after parturition (T 2, n = 14). 14 untreated ewes served as controls (C). Suckling lambs (n = 58) remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T 1) and 96.9% (T 2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T 1 (94.8%) and T 2 (96.7%) ewes (p ewes-group independent increase in FEC before weaning (p < 0.05). Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences (p < 0.05). Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER. PMID:26078913

Characterization of a recurrent t(1;2)(p36;p24) in human uterine leiomyoma.

NARCIS (Netherlands)

Rijk, A. van; Sweers, M.A.; Huys, E.; Kersten, M.; Merkx, G.F.M.; Geurts van Kessel, A.H.M.; Debiec-Rychter, M.; Schoenmakers, E.F.P.M.

2009-01-01

Uterine leiomyomas are the most common neoplasms in women of reproductive age. Approximately 40% of these neoplasms show recurring structural cytogenetic anomalies, including del(7)(q22), t(12;14)(q15;q24), t(1;2)(p36;p24), and anomalies affecting 6p21 or 10q22. Using positional cloning strategies,

Conditional cancer-specific mortality in T4, N1, or M1 prostate cancer: implications for long-term prognosis

International Nuclear Information System (INIS)

Muralidhar, Vinayak; Mahal, Brandon A.; Nguyen, Paul L.

2015-01-01

The risk of prostate cancer-specific mortality (PCSM) following a diagnosis of prostate cancer may improve after patients have survived a number of years after diagnosis. We sought to determine long-term conditional PCSM for patients with stage T4, N1, or M1 prostate cancer. We identified 66,817 patients diagnosed with stage IV (T4N0M0, N1M0, or M1) prostate cancer between 1973 and 2011 using the Surveillance, Epidemiology, and End Results (SEER) database. Conditional five-year PCSM was evaluated for each group of patients at 5, 10, and 15 years of survival according to the Fine & Gray model for competing risks after adjusting for tumor grade, age, income level, and marital status. Race-stratified analyses were also performed. There were 13,345 patients with T4 disease, 12,450 patients with N1 disease, and 41,022 patients with M1 disease. Median follow-up among survivors in the three groups was 123 months (range: 0–382 months), 61 months (range: 0–410 months), and 30 months (range: 0–370 months), respectively. Conditional PCSM improved in all three groups over time. Among patients with T4 disease, 5-year PCSM improved from 13.9 % at diagnosis to 11.2, 8.1, and 6.5 % conditioned on 5, 10, or 15 years of survival, respectively (p < 0.001 in all cases). In patients with N1 disease, 5-year PCSM increased within the first five years and decreased thereafter, from 18.9 % at diagnosis to 21.4 % (p < 0.001), 17.6 % (p = 0.055), and 13.8 % (p < 0.001), respectively. In patients with metastatic disease, 5-year PCSM improved from 57.2 % at diagnosis to 41.1, 28.8, and 20.8 %, respectively (p < 0.001). White race was associated with a greater increase in conditional survival compared to non-white race among those with T4 or N1 disease. While patients with T4, N1, or M1 prostate cancer are never “cured,” their odds of cancer-specific survival increase substantially after they have survived for 5 or more years. Physicians who take care of patients with prostate cancer

Wall conditioning with a high magnetic field in HT-7 superconducting tokamak

International Nuclear Information System (INIS)

Li Jiangang; Gu Xuemao; Gao Xiang; Zhang Souying; Jie Yingxian; Yang Xiaokang

2000-01-01

ICRF wall conditioning techniques, which includes the hydrogen removal, impurity cleaning, boronization and siliconization, were described in this paper. This new technique has been demonstrated to be very effective for wall conditioning, recycling, isotopic control and used daily during experiments. The RF plasma parameters were measured as T e =3-8 eV, T i =0.5-2 keV, n e =0.3-5 x 10 17 m -3 by different diagnostics. The nontoxic and nonexplosive solid carborane powder was used for the RF boronization. Energetic ions cracked the carborane molecule and the boron ions impacted and deposited onto first wall. Comparing with GDC boronization, the B/C coating film shows the higher adhesion, better uniformity and longer lifetime to the plasma discharges. Siliconization was carried out by using a high field side long RF antenna, which made the discharge more uniform. The ratio of SiH 4 to helium is about 5:95 at the pressure range of P v =0.8-8 x 10 -2 Pa. Compare with boronization, it showed quicker recovery from a bad wall condition due to leakage of air to good wall condition. Plasma density could be easily controlled after siliconization. But the lifetime is much shorter than that obtained by boronization. Plasma performance has been improved after RF boronization and siliconization. (author)

Search for Dark Matter in events with a hight- pT photon and high missing transverse momentum in ATLAS

Science.gov (United States)

Ratti, M. G.

2016-01-01

We present the results of a search for new particles in events with a high-pT photon and high missing transverse momentum with the ATLAS experiment at the LHC. The analysis is performed on the data collected by ATLAS at a centre of mass energy of 8TeV and corresponding to a total integrated luminosity of 20.3 fb-1 . No excess has been found with respect to the Standard Model expectation. A model-independent upper limit on the fiducial cross section for the production of events with a photon and large missing transverse momentum is set. Exclusion limits on the direct pair production of dark matter candidates are presented.

Synthesis, purification and characterization of [3,5 - T] p-aminobenzoic acid

International Nuclear Information System (INIS)

Corol-Cucu, Delia-Irina; Chiper, Diana; Mihaila, V.; Negoita, N.

2000-01-01

This paper refers to the synthesis, purification and characterization of [3,5-T] p-aminobenzoic acid (PAB,H' vitamine). The p-aminobenzoic acid is used in the treatment of rheumatic arthritis and dermatological affections. The advantage of tritium labelling of p-aminobenzoic acid is that some biomedical important aspects of collagen's behaviour are made clear. The PAB stimulate the grow of intestinal bacteria so necessary to synthesis of some vitamins (bio tine, pantothenic acid). Tritium is the only radioactive isotope of hydrogen. Several steps have to be carried out in the synthesis of the final product as well as to study its biological behavior. For the labelling of PAB one prefers the substitution of bromine from PAB-3,5-Br with tritium because of simplicity of reaction and the easy synthesis of halogen compound. The first step in synthesis is the protection of NH 2 group through acetylation of PAB. After that PAB is bromated into the 3 and 5 position with elementary bromine. The raw compound is purified and recrystallized and characterized through thin layer chromatography.The tritium labelling is performed through substitution of bromine from bromate derivative, using Pd/C (10% Pd) as catalyst and low basic conditions for the neutralization of HBr resulting from reaction. After the separation of PAB-3,5-T through filtration, the catalyst remains on the filter paper and the labelled compound goes in aqueous solution. PAB-3,5-T is purified through thin layer chromatography with the solvent system n-BuOH:NH 4 OH(25%):H 2 O:EtOH (8:1:2:2,5, v/v) with silica gel GF 254 as support. The determination of activity is carried out with LSC (Liquid Scintillation Counter). A 98% purity was determined through TLC in the same conditions while determination of activity distribution was performed with a 2π Berthold scanner with gas running and without window. The chemical concentration has been measured through UV spectrophotometry and by comparing extinction with

P and T violations in QED

International Nuclear Information System (INIS)

Pleitez, V.

1983-01-01

An abelian gauge theory with violation of P and T symmetries, is constructed other features of usual spinor quantum electrodynamics are maintained. The theory is applied to some scattering processes with polarized and unpolarized electrons. (Author) [pt

High pT charm photoproduction

International Nuclear Information System (INIS)

Abbiendi, G.; Butterworth, J.M.

1996-09-01

The expected rates for charm-tagged jet photoproduction are evaluated for a number of tagging procedures, and some of the physics potential is discussed. Charm in jets is tagged using D * 's, μ's, or tracks from secondary vertices which might be identified in a microvertex detector. We find high expected event rates, leading to the possibility of placing strong constraints on the kinematics of charm production and on the gluon content of the proton and the charm content of the photon. (orig.)

pT spectra in pp and AA collisions at RHIC and LHC energies using the Tsallis-Weibull approach

Science.gov (United States)

Dash, Sadhana; Mahapatra, D. P.

2018-04-01

The Tsallis q -statistics have been incorporated in the Weibull model of particle production, in the form of q-Weibull distribution, to describe the transverse momentum (pT) distribution of charged hadrons at mid-rapidity, measured at RHIC and LHC energies. The q-Weibull distribution is found to describe the observed pT distributions over all ranges of measured pT. Below 2.2 GeV/c, while going from peripheral to central collisions, the parameter q is found to decrease systematically towards unity, indicating an evolution from a non-equilibrated system in peripheral collisions, towards a more thermalized system in central collisions. However, the trend is reversed in the all inclusive pT regime. This can be attributed to an increase in relative contribution of hard pQCD processes in central collisions. The λ-parameter is found to be associated with the mean pT or the collective expansion velocity of the produced hadrons, which shows an expected increase with centrality of collisions. The k parameter is observed to increase with the onset of hard QCD scatterings, initial fluctuations, and other processes leading to non-equilibrium conditions.

Review of ADS and P and T Programme in Japan

International Nuclear Information System (INIS)

Oigawa, H.

2015-01-01

The partitioning and transmutation (P and T) technology to reduce the burden of high-level radioactive waste management is recently receiving more public attention than ever before in Japan. In this context, the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan launched a Working Party to review research and development (R and D) on P and T using an Accelerator Driven System (ADS), and issued an interim report of the Working Party in November 2013. Although P and T concept with ADS, called 'Double-strata Fuel Cycle', had been regarded as a backup option of that with a Fast Breeder Reactor, the Working Party recommended to change the R and D phase of this technology from a fundamental stage to a principle demonstration stage. For ADS, the Working Party recommended to promote the R and D toward the Transmutation Experimental Facility of J-PARC, though further technical evaluation was requested to start its construction. The Working Party also recommended to consistently facilitate various R and D for other technical areas than ADS in parallel. Such technical areas include partitioning process for minor actinides and fission products, and dedicated transmutation fuel and its cycle. A consolidated road-map toward the realisation of this technology was also discussed in the Working Party. (author)

The p.T191M mutation of the CBS gene is highly prevalent among homocystinuric patients from Spain, Portugal and South America.

Science.gov (United States)

Urreizti, Roser; Asteggiano, Carla; Bermudez, Marta; Córdoba, Alfonso; Szlago, Marina; Szlago, Mariana; Grosso, Carola; de Kremer, Raquel Dodelson; Vilarinho, Laura; D'Almeida, Vania; Martínez-Pardo, Mercedes; Peña-Quintana, Luís; Dalmau, Jaime; Bernal, Jaime; Briceño, Ignacio; Couce, María Luz; Rodés, Marga; Vilaseca, Maria Antonia; Balcells, Susana; Grinberg, Daniel

2006-01-01

Classical homocystinuria is due to cystathionine beta-synthase (CBS) deficiency. More than 130 mutations, which differ in prevalence and severity, have been described at the CBS gene. Mutation p.I278T is very prevalent, has been found in all European countries where it has been looked for with the exception of the Iberian peninsula, and is known to respond to vitamin B6. On the other hand, mutation p.T191M is prevalent in Spain and Portugal and does not respond to B6. We analysed 30 pedigrees from Spain, Portugal, Colombia and Argentina, segregating for homocystinuria. The p.T191M mutation was detected in patients from all four countries and was particularly prevalent in Colombia. The number of p.T191M alleles described in this study, together with those previously published, is 71. The prevalence of p.T191M among CBS mutant alleles in the different countries was: 0.75 in Colombia, 0.52 in Spain, 0.33 in Portugal, 0.25 in Venezuela, 0.20 in Argentina and 0.14 in Brazil. Haplotype analyses suggested a double origin for this mutation. No genotype-phenotype correlation other than the B6-nonresponsiveness could be established for the p.T191M mutation. Additionally, three new mutations, p.M173V, p.I429del and c.69_70+8del10, were found. The p.M173V was associated with a mild, B6-responsive, phenotype.

Virtual photoproduction of hadrons at large p/sub T/ as a probe for gluon bremsstrahlung

CERN Document Server

Floratos, Emmanuel G

1978-01-01

In a SU/sub 3, colour/ x SU/sub 3, flavour/ invariant interaction of quarks and gluons, where the colour degree of freedom is locally gauged, first-order corrections of the naive parton model are calculated for the one-hadron inclusive virtual photoproduction. The high p/sub T/ distribution of hadrons is studied and the kinetical region in which the prediction of the model dominates over the fall- off approximately exp(-bp/sub T//sup 2/) which seems to be supported by the low-p/sub T/ available experimental data is determined. (29 refs).

A Method for the Preparation of Chicken Liver P?t? that Reliably Destroys Campylobacters

OpenAIRE

Hutchison, Mike; Harrison, Dawn; Richardson, Ian; Tch?rzewska, Monika

2015-01-01

This study devised a protocol for the manufacture of commercial quantities of chicken liver pâté that reliably destroyed campylobacters. A literature search identified 40 pâté manufacture recipes. Recipes stages with a potential to be antimicrobial were assembled to form a new protocol that included washing with organic acid, freeze-thaw and flambé in alcohol. Naturally-contaminated, high-risk livers were obtained from clearance flocks at slaughter and the effect of each stage of the protoco...

Dihadron correlations at high pT

International Nuclear Information System (INIS)

Filimonov, Kirill

2004-01-01

Jet quenching in the matter created in high energy nucleus/nucleus collisions provides a tomographic tool to probe the medium properties. Recent experimental results from the Relativistic Heavy-Ion Collider (RHIC) on characterization of jet production via dihadron correlations at high transverse momentum are reviewed. Expectations from the dihadron measurements for the lower energy √s NN = 62.4 GeV RHIC run are discussed

(p,t) strengths in the Ga isotopes

International Nuclear Information System (INIS)

Rotbard, G.; Vergnes, M.; Berrier-Ronsin, G.; Vernotte, J.; Tamisier, R.

1984-01-01

The (p,t) reaction on the two stable Ga isotopes has been performed at 25 MeV, with 11 keV energy resolution. Levels up to 3.5 MeV in 67 Ga, 4.3 MeV in 69 Ga were measured. Differences observed in comparing the distribution of the L=2 (p,t) strength with the distribution of the B(E2) strength may be explained by a mixed character of the 7/2 2 - level wave function. The distribution of the L=0 strength indicates that the striking change in ground-state structure shown between N=40 and 42 already begins, although weakly, between N=38 and 40

Roles of iron species and pH optimization on sewage sludge conditioning with Fenton's reagent and lime.

Science.gov (United States)

Yu, Wenbo; Yang, Jiakuan; Shi, Yafei; Song, Jian; Shi, Yao; Xiao, Jun; Li, Chao; Xu, Xinyu; He, Shu; Liang, Sha; Wu, Xu; Hu, Jingping

2016-05-15

sludge cakes were obtained, with less small pores (1-10 nm) that contributed to water affinity, but with more large pores (>10 nm) that contributed to a permeable, rigid lattice structure. Morphology of the Fenton-conditioned sludge cake exhibited a porous structure. The estimated cost of the composite conditioner, Fenton's reagent and lime, is USD$ 43.8/t DS, which is less than that of ferric chloride and lime (USD$ 54/t DS). Furthermore, pH of the final filtrate using this composite conditioner is about 6.6. Comparatively, that using ferric chloride and lime is as high as 12.4. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cosmological viability conditions for f(T) dark energy models

Energy Technology Data Exchange (ETDEWEB)

Setare, M.R.; Mohammadipour, N., E-mail: rezakord@ipm.ir, E-mail: N.Mohammadipour@uok.ac.ir [Department of Science, University of Kurdistan, Sanandaj (Iran, Islamic Republic of)

2012-11-01

Recently f(T) modified teleparallel gravity where T is the torsion scalar has been proposed as the natural gravitational alternative for dark energy. We perform a detailed dynamical analysis of these models and find conditions for the cosmological viability of f(T) dark energy models as geometrical constraints on the derivatives of these models. We show that in the phase space exists two cosmologically viable trajectory which (i) The universe would start from an unstable radiation point, then pass a saddle standard matter point which is followed by accelerated expansion de sitter point. (ii) The universe starts from a saddle radiation epoch, then falls onto the stable matter era and the system can not evolve to the dark energy dominated epoch. Finally, for a number of f(T) dark energy models were proposed in the more literature, the viability conditions are investigated.

[Relationship between body condition (back fat thickness and body condition scoring) and fertility in dairy cows (German Black Pied/HF)].

Science.gov (United States)

Gossen, N; Fietze, S; Mösenfechtel, S; Hoedemaker, M

2006-05-01

It was the aim of this study to compare body condition scoring with ultrasonographic back fat thickness. Additionally, the relationship between back fat thickness and fertility, milk yield, number of parity and stage of lactation in dairy cows was examined. Body condition of 211 cows (German Black Pied/HF) was determined by means of ultrasonographic back fat thickness (BFT) and body condition scoring (BCS). The BFT and the BCS were measured at four different stages during the course of lactation (Time point 1 (T1) = 1.-3. d postpartum (pp); T2 = 40.-42. d pp; T3 = 90.-92. d pp and T4 = 130.-150. d pp). Number of parity, 100-day-milk-yield, incidence of ovarian cysts, incidence of acyclicity and fertility measures were recorded. There was a significant correlation between body condition scoring and ultrasonographic measurement of back fat thickness at the four time points (r = 0.68 to 0.74). Therefore, both methods were suitable to evaluate body condition. The number of lactations had an influence on body condition. At T1, the BFT in older cows was significantly higher than in younger cows (P cows was higher than in older cows (P body condition from T1 to T2 and T3. At T4, body condition increased, but did not reach the level of the postcalving values. In addition, cows with a high BFT at the beginning of lactation had a higher milk yield and a higher loss of body fat than cows with lower milk yield. Heifers compensated this loss of body fat significantly faster than older cows. Particularly at T3, body condition had an impact on fertility. Cows with a high loss of body condition between T1 and T3 developed significantly more often ovarian cysts than cows with low loss of back fat thickness. Cows with the lowest BFT at T3 had the longest calving to first service intervall and the highest 200-day-non-pregnancy index. In conclusion, our results suggest that there might be a certain relationship between body condition and fertility (delayed first service, ovarian

Eesti põllumajanduse töötervishoiu ja tööohutuse profiil / Marina Kempinen, Kari Kurppa

Index Scriptorium Estoniae

Kempinen, Marina

2005-01-01

Eesti põllumajanduse töötervishoiu ja -ohutuse sektoraalne profiil koostati põllumajanduse töötervishoiu võrgustiku raames ühe osana Eesti-Soome koostööprojektist töötervishoiuteenuste alal (2003-2004). Tabel: SWOT-analüüsi tulemused

Confronting lepton flavor universality violation in B decays with high-pT tau lepton searches at LHC

Directory of Open Access Journals (Sweden)

Darius A. Faroughy

2017-01-01

Full Text Available We confront the indications of lepton flavor universality (LFU violation observed in semi-tauonic B meson decays with new physics (NP searches using high pT tau leptons at the LHC. Using effective field theory arguments we correlate possible non-standard contributions to semi-tauonic charged currents with the τ+τ− signature at high energy hadron colliders. Several representative standard model extensions put forward to explain the anomaly are examined in detail: (i weak triplet of color-neutral vector resonances, (ii second Higgs doublet and (iii scalar or (iv vector leptoquark. We find that, in general, τ+τ− searches pose a serious challenge to NP explanations of the LFU anomaly. Recasting existing 8 TeV and 13 TeV LHC analyses, stringent limits are set on all considered simplified models. Future projections of the τ+τ− constraints as well as caveats in interpreting them within more elaborate models are also discussed.

Planetesimal core formation with partial silicate melting using in-situ high P, high T, deformation x-ray microtomography

Science.gov (United States)

Anzures, B. A.; Watson, H. C.; Yu, T.; Wang, Y.

2017-12-01

Differentiation is a defining moment in formation of terrestrial planets and asteroids. Smaller planetesimals likely didn't reach high enough temperatures for widescale melting. However, we infer that core formation must have occurred within a few million years from Hf-W dating. In lieu of a global magma ocean, planetesimals likely formed through inefficient percolation. Here, we used in-situ high temperature, high pressure, x-ray microtomography to track the 3-D evolution of the sample at mantle conditions as it underwent shear deformation. Lattice-Boltzmann simulations for permeability were used to characterize the efficiency of melt percolation. Mixtures of KLB1 peridotite plus 6.0 to 12.0 vol% FeS were pre-sintered to achieve an initial equilibrium microstructure, and then imaged through several consecutive cycles of heating and deformation. The maximum calculated melt segregation velocity was found to be 0.37 cm/yr for 6 vol.% FeS and 0.61 cm/year for 12 vol.% FeS, both below the minimum velocity of 3.3 cm/year required for a 100km planetesimal to fully differentiate within 3 million years. However, permeability is also a function of grain size and thus the samples having smaller grains than predicted for small planetesimals could have contributed to low permeability and also low migration velocity. The two-phase (sulfide melt and silicate melt) flow at higher melt fractions (6 vol.% and 12 vol.% FeS) was an extension of a similar study1 containing only sulfide melt at lower melt fraction (4.5 vol.% FeS). Contrary to the previous study, deformation did result in increased permeability until the sample was sheared by twisting the opposing Drickamer anvils by 360 degrees. Also, the presence of silicate melt caused the FeS melt to coalesce into less connected pathways as the experiment with 6 vol.% FeS was found to be less permeable than the one with 4.5 vol.% FeS but without any partial melt. The preliminary data from this study suggests that impacts as well as

Longitudinal double spin asymmetries in single hadron quasi-real photoproduction at high pT

Directory of Open Access Journals (Sweden)

C. Adolph

2016-02-01

Full Text Available We measured the longitudinal double spin asymmetries ALL for single hadron muoproduction off protons and deuterons at photon virtuality Q2<1(GeV/c2 for transverse hadron momenta pT in the range 1 GeV/c to 4 GeV/c. They were determined using COMPASS data taken with a polarised muon beam of 160 GeV/c or 200 GeV/c impinging on polarised 6LiD or NH3 targets. The experimental asymmetries are compared to next-to-leading order pQCD calculations, and are sensitive to the gluon polarisation ΔG inside the nucleon in the range of the nucleon momentum fraction carried by gluons 0.05

HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals

Directory of Open Access Journals (Sweden)

Satou Yorifumi

2012-05-01

Full Text Available Abstract Background HTLV-1 utilizes CD4 T cells as the main host cell and maintains the proviral load via clonal proliferation of infected CD4+ T cells. Infection of CD4+ T cells by HTLV-1 is therefore thought to play a pivotal role in HTLV-1-related pathogenicity, including leukemia/lymphoma of CD4+ T cells and chronic inflammatory diseases. Recently, it has been reported that a proportion of HTLV-1 infected CD4+ T cells express FoxP3, a master molecule of regulatory T cells. However, crucial questions remain unanswered on the relationship between HTLV-1 infection and FoxP3 expression. Results To investigate the effect of HTLV-1 infection on CD4+ T-cell subsets, we used flow cytometry to analyze the T-cell phenotype and HTLV-1 infection in peripheral mononuclear cells (PBMCs of four groups of subjects, including 23 HTLV-1-infected asymptomatic carriers (AC, 10 patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP, 10 patients with adult T-cell leukemia (ATL, and 10 healthy donors. The frequency of FoxP3+ cells in CD4+ T cells in AC with high proviral load and patients with HAM/TSP or ATL was higher than that in uninfected individuals. The proviral load was positively correlated with the percentage of CD4+ T cells that were FoxP3+. The CD4+FoxP3+ T cells, themselves, were frequently infected with HTLV-1. We conclude that FoxP3+ T- cells are disproportionately infected with HTLV-1 during chronic infection. We next focused on PBMCs of HAM/TSP patients. The expression levels of the Treg associated molecules CTLA-4 and GITR were decreased in CD4+FoxP3+ T cells. Further we characterized FoxP3+CD4+ T-cell subsets by staining CD45RA and FoxP3, which revealed an increase in CD45RA−FoxP3low non-suppressive T-cells. These findings can reconcile the inflammatory phenotype of HAM/TSP with the observed increase in frequency of FoxP3+ cells. Finally, we analyzed ATL cells and observed not only a high frequency of FoxP3 expression

Flux Balance Analysis of Escherichia coli under Temperature and pH Stress Conditions

KAUST Repository

Xu, Xiaopeng

2015-05-12

An interesting discovery in biology is that most genes in an organism are dispensable. That means these genes have minor effects on survival of the organism in standard laboratory conditions. One explanation of this discovery is that some genes play important roles in specific conditions and are essential genes under those conditions. E. coli is a model organism, which is widely used. It can adapt to many stress conditions, including temperature, pH, osmotic, antibiotic, etc. Underlying mechanisms and associated genes of each stress condition responses are usually different. In our analysis, we combined protein abundance data and mutant conditional fitness data into E. coli constraint-based metabolic models to study conditionally essential metabolic genes under temperature and pH stress conditions. Flux Balance Analysis was employed as the modeling method to analysis these data. We discovered lists of metabolic genes, which are E. coli dispensable genes, but conditionally essential under some stress conditions. Among these conditionally essential genes, atpA in low pH stress and nhaA in high pH stress found experimental evidences from previous studies. Our study provides new conditionally essential gene candidates for biologists to explore stress condition mechanisms.

Jet pT resummation in Higgs production at NNLL'+NNLO

International Nuclear Information System (INIS)

Stewart, Iain W.; Tackmann, Frank J.; Walsh, Jonathan R.; Zuberi, Saba

2013-07-01

We present predictions for Higgs production via gluon fusion with a p T veto on jets and with the resummation of jet-veto logarithms at NNLL'+NNLO order. These results incorporate explicit O(α s 2 ) calculations of soft and beam functions, which include the dominant dependence on the jet radius R. In particular the NNLL' order accounts for the correct boundary conditions for the N 3 LL resummation, for which the only unknown ingredients are higher-order anomalous dimensions. We use scale variations in a factorization theorem in both rapidity and virtuality space to estimate the perturbative uncertainties, accounting for both higher fixed-order corrections as well as higher-order towers of jet-p T logarithms. This formalism also predicts the correlations in the theory uncertainty between the exclusive 0-jet and inclusive 1-jet bins. At the values of R used experimentally, there are important corrections due to jet algorithm clustering that include logarithms of R. Although we do not sum logarithms of R, we do include an explicit contribution in our uncertainty estimate to account for higher-order jet clustering logarithms. Precision predictions for this H+0-jet cross section and its theoretical uncertainty are an integral part of Higgs analyses that employ jet binning.

CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells.

Science.gov (United States)

Solstad, Therese; Bains, Simer Jit; Landskron, Johannes; Aandahl, Einar Martin; Thiede, Bernd; Taskén, Kjetil; Torgersen, Knut Martin

2011-11-10

Human CD4(+)FoxP3(+) T cells are functionally and phenotypically heterogeneous providing plasticity to immune activation and regulation. To better understand the functional dynamics within this subset, we first used a combined strategy of subcellular fractionation and proteomics to describe differences at the protein level between highly purified human CD4(+)CD25(+) and CD4(+)CD25(-) T-cell populations. This identified a set of membrane proteins highly expressed on the cell surface of human regulatory T cells (Tregs), including CD71, CD95, CD147, and CD148. CD147 (Basigin or Emmprin) divided CD4(+)CD25(+) cells into distinct subsets. Furthermore, CD147, CD25, FoxP3, and in particular CTLA-4 expression correlated. Phenotypical and functional analyses suggested that CD147 marks the switch between resting (CD45RA(+)) and activated (CD45RO(+)) subsets within the FoxP3(+) T-cell population. Sorting of regulatory T cells into CD147(-) and CD147(+) populations demonstrated that CD147 identifies an activated and highly suppressive CD45RO(+) Treg subset. When analyzing CD4(+) T cells for their cytokine producing potential, CD147 levels grouped the FoxP3(+) subset into 3 categories with different ability to produce IL-2, TNF-α, IFN-γ, and IL-17. Together, this suggests that CD147 is a direct marker for activated Tregs within the CD4(+)FoxP3(+) subset and may provide means to manipulate cells important for immune homeostasis.

SV40 large T-p53 complex: evidence for the presence of two immunologically distinct forms of p53

International Nuclear Information System (INIS)

Milner, J.; Gamble, J.

1985-01-01

The transforming protein of SV40 is the large T antigen. Large T binds a cellular protein, p53, which is potentially oncogenic by virtue of its functional involvement in the control of cell proliferation. This raises the possibility that p53 may mediate, in part, the transforming function of SV40 large T. Two immunologically distinct forms of p53 have been identified in normal cells: the forms are cell-cycle dependent, one being restricted to nondividing cells (p53-Go) and the second to dividing cells (p53-G divided by). The authors have now dissociated and probed the multimeric complex of SV40 large T-p53 for the presence of immunologically distinct forms of p53. Here they present evidence for the presence of p53-Go and p53-G divided by complexed with SV40 large T

The iron waste from thermal power plant (t.p.p.) as the source of radioactive contamination

International Nuclear Information System (INIS)

Kovacevic, M.; Todorovic, D.; Radenkovic, M.; Joksic, J.; Vukcevic, M.

2006-01-01

The radioactivity control of the iron waste (tubes) raised from the regular maintenance of the Gacko thermo power plant has shown the allocated spots of relatively high surface contamination, mainly beta, and no enhanced levels of absorbed radiation dose in the air. Further laboratory examination of the contaminated tube samples (10- 15 cm length) determined the level and source of contamination. Gamma spectrometry (H.P. Ge, efficiency 23%) has shown the presence of 210 Pb isotope, beta-emitting radionuclide with 47 keV X-ray emission, the member of the 238 U series. The surface contamination and concentration values, determined after samples dissolution in mineral acids, are 2.4 Bq/cm 2 and 0.6 Bq/g, respectively. The radioactivity of the tubes originate from the naturally occurring radionuclides in coal, with 210 Pb activities mostly within 0.01-0.05 Bq/g. During the T.P.P. work, radioactivity is deposed with ash, flying ash and slag and partly released into atmosphere. But, the part of radioactivity is deposited at the tubes and cauldron with gases emanated during the coal combustion. In this way, the iron becomes contaminated by the natural radionuclide during the technological process. Since there are no legislative stipulations about such cases, we have applied the international recommendations saying that dose limit should not be higher than 10 Micro Sv/year for individuals. On this basis T.E.C.D.O.C. 855 define different use of metals contaminated with natural or man-made radionuclides. According this document the contaminated iron with activity lower than 0.7 Bq/g may be further processed in the steel works that is the case with the iron waste produced in the T.P.P. Gacko. (authors)

High Quality Draft Genomes of the Type Strains Geobacillus thermocatenulatus DSM 730T, G. uzenensis DSM 23175T And Parageobacillus galactosidasius DSM 18751T.

Science.gov (United States)

Ramaloko, Winnie Thabisa; Koen, Nadine; Polliack, Shamara; Aliyu, Habibu; Lebre, Pedro Humberto; Mohr, Teresa; Oswald, Florian; Zwick, Michaela; Zeigler, Daniel Ray; Neumann, Anke; Syldatk, Christoph; Cowan, Don Arthur; De Maayer, Pieter

2018-01-01

The thermophilic 'Geobacilli' are important sources of thermostable enzymes and other biotechnologically relevant macromolecules. The present work reports the high quality draft genome sequences of previously unsequenced type strains of Geobacillus uzenensis (DSM 23175 T ), G. thermocatenulatus (DSM 730 T ) and Parageobacillus galactosidasius (DSM 18751 T ). Phylogenomic analyses revealed that DSM 18751 T and DSM 23175 T represent later heterotypic synonyms of P. toebii and G. subterraneus , respectively, while DSM 730 T represents the type strain for the species G. thermocatenulatus . These genome sequences will contribute towards a deeper understanding of the ecological and biological diversity and the biotechnological exploitation of the 'geobacilli'.

Longitudinal double spin asymmetries in single hadron quasi-real photoproduction at high $p_T$

CERN Document Server

Adolph, C; Alexeev, M G; Alexeev, G D; Amoroso, A; Andrieux, V; Anosov, V; Augustyniak, W; Austregesilo, A; Azevedo, C D R; Badełek, B; Balestra, F; Barth, J; Beck, R; Bedfer, Y; Bernhard, J; Bicker, K; Bielert, E R; Birsa, R; Bisplinghoff, J; Bodlak, M; Boer, M; Bordalo, P; Bradamante, F; Braun, C; Bressan, A; Büchele, M; Burtin, E; Chang, W-C; Chiosso, M; Choi, I; Chung, S U; Cicuttin, A; Crespo, M L; Curiel, Q; Dalla Torre, S; Dasgupta, S S; Dasgupta, S; Denisov, O Yu; Dhara, L; Donskov, S V; Doshita, N; Duic, V; Dünnweber, W; Dziewiecki, M; Efremov, A; Eversheim, P D; Eyrich, W; Faessler, M; Ferrero, A; Finger, M; Finger jr , M; Fischer, H; Franco, C; du Fresne von Hohenesche, N; Friedrich, J M; Frolov, V; Fuchey, E; Gautheron, F; Gavrichtchouk, O P; Gerassimov, S; Giordano, F; Gnesi, I; Gorzellik, M; Grabmüller, S; Grasso, A; Grosse Perdekamp, M; Grube, B; Grussenmeyer, T; Guskov, A; Haas, F; Hahne, D; von Harrach, D; Hashimoto, R; Heinsius, F H; Herrmann, F; Hinterberger, F; Horikawa, N; d'Hose, N; Hsieh, C-Y; Huber, S; Ishimoto, S; Ivanov, A; Ivanshin, Yu; Iwata, T; Jahn, R; Jary, V; Joosten, R; Jörg, P; Kabuß, E; Ketzer, B; Khaustov, G V; Khokhlov, Yu A; Kisselev, Yu; Klein, F; Klimaszewski, K; Koivuniemi, J H; Kolosov, V N; Kondo, K; Königsmann, K; Konorov, I; Konstantinov, V F; Kotzinian, A M; Kouznetsov, O; Krämer, M; Kremser, P; Krinner, F; Kroumchtein, Z V; Kuchinski, N; Kuhn, R; Kunne, F; Kurek, K; Kurjata, R P; Lednev, A A; Lehmann, A; Levillain, M; Levorato, S; Lichtenstadt, J; Longo, R; Maggiora, A; Magnon, A; Makins, N; Makke, N; Mallot, G K; Marchand, C; Marianski, B; Martin, A; Marzec, J; Matoušek, J; Matsuda, H; Matsuda, T; Meshcheryakov, G; Meyer, W; Michigami, T; Mikhailov, Yu V; Miyachi, Y; Montuenga, P; Nagaytsev, A; Nerling, F; Neyret, D; Nikolaenko, V I; Nový, J; Nowak, W-D; Nukazuka, G; Nunes, A S; Olshevsky, A G; Orlov, I; Ostrick, M; Panzieri, D; Parsamyan, B; Paul, S; Peng, J-C; Pereira, F; Pešek, M; Peshekhonov, D V; Platchkov, S; Pochodzalla, J; Polyakov, V A; Pretz, J; Quaresma, M; Quintans, C; Ramos, S; Regali, C; Reicherz, G; Riedl, C; Rossiyskaya, N S; Ryabchikov, D I; Rychter, A; Samoylenko, V D; Sandacz, A; Santos, C; Sarkar, S; Savin, I A; Sbrizzai, G; Schiavon, P; Schmidt, K; Schmieden, H; Schönning, K; Schopferer, S; Selyunin, A; Shevchenko, O Yu; Silva, L; Sinha, L; Sirtl, S; Slunecka, M; Sozzi, F; Srnka, A; Stolarski, M; Sulc, M; Suzuki, H; Szabelski, A; Szameitat, T; Sznajder, P; Takekawa, S; Tessaro, S; Tessarotto, F; Thibaud, F; Tosello, F; Tskhay, V; Uhl, S; Veloso, J; Virius, M; Weisrock, T; Wilfert, M; ter Wolbeek, J; Zaremba, K; Zavertyaev, M; Zemlyanichkina, E; Ziembicki, M; Zink, A

2016-01-01

We measured the longitudinal double spin asymmetries $A_{LL}$ for single hadron muo-production off protons and deuterons at photon virtuality $Q^2$ < 1(GeV/$\\it c$)$^2$ for transverse hadron momenta $p_T$ in the range 0.7 GeV/$\\it c$ to 4 GeV/$\\it c$ . They were determined using COMPASS data taken with a polarised muon beam of 160 GeV/$\\it c$ or 200 GeV/$\\it c$ impinging on polarised $\\mathrm{{}^6LiD}$ or $\\mathrm{NH_3}$ targets. The experimental asymmetries are compared to next-to-leading order pQCD calculations, and are sensitive to the gluon polarisation $\\Delta G$ inside the nucleon in the range of the nucleon momentum fraction carried by gluons $0.05 < x_g < 0.2$.

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions.

Science.gov (United States)

Gurav, Ashish; Sivaprakasam, Sathish; Bhutia, Yangzom D; Boettger, Thomas; Singh, Nagendra; Ganapathy, Vadivel

2015-07-15

Mammalian colon harbours trillions of bacteria under physiological conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. In the present study we show that Slc5a8 (solute carrier gene family 5a, member 8), a Na(+)-coupled high-affinity transporter in colon for the bacterial fermentation product butyrate, plays a critical role in this process. Among various immune cells in colon, dendritic cells (DCs) are unique not only in their accessibility to luminal contents but also in their ability to induce tolerogenic phenotype in T-cells. We found that DCs exposed to butyrate express the immunosuppressive enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and aldehyde dehydrogenase 1A2 (Aldh1A2), promote conversion of naive T-cells into immunosuppressive forkhead box P3(+) (FoxP3(+)) Tregs (regulatory T-cells) and suppress conversion of naive T-cells into pro-inflammatory interferon (IFN)-γ-producing cells. Slc5a8-null DCs do not induce IDO1 and Aldh1A2 and do not generate Tregs or suppress IFN-γ-producing T-cells in response to butyrate. We also provide in vivo evidence for an obligatory role for Slc5a8 in suppression of IFN-γ-producing T-cells. Furthermore, Slc5a8 protects against colitis and colon cancer under conditions of low-fibre intake but not when dietary fibre intake is optimal. This agrees with the high-affinity nature of the transporter to mediate butyrate entry into cells. We conclude that Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content. © 2015 Authors; published by Portland Press Limited.

Measurement of the t(bar t) production cross section in p(bar p) collisions at √s - 1.96 Tev using dilepton event

International Nuclear Information System (INIS)

Acosta, D.; CDF Collaboration

2004-01-01

We report a measurement of the t(bar t) production cross section using dilepton events with jets and missing transverse energy in p(bar p) collisions at a center-of-mass energy of 1.96 TeV. Using a 197 ± 12 pb -1 data sample recorded by the upgraded Collider Detector at Fermilab, we use two complementary techniques to select candidate events. We compare the number of observed events and selected kinematical distributions with the predictions of the standard model and find good agreement. The combined result of the two techniques yields a t(bar t) production cross section of 7.0 -2.1 +2.4 (stat) -1.1 1 .6 (syst) ± 0.4(lum) pb

P-T data from central Bhutan imply distributed extensional shear at the Black Mountain "klippe"

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Corrie, S. L.; Kohn, M. J.; Long, S. P.; McQuarrie, N.; Tobgay, T.

2011-12-01

The Southern Tibetan Detachment system (STDS) occurs along the entire length of the Himalayan orogen, and extensionally emplaces low-grade to unmetamorphosed Tethyan Himalayan (TH) rocks over highly metamorphosed Greater Himalayan sequence (GH) rocks. The base of TH remnants preserved in northern Bhutan all have top-to-the-north shear sense indicators (C'-type shear bands, asymmetric folds, and boudinaged leucogranite dikes) that are interpreted to reflect a discrete shear zone. In contrast, the GH-TH contact in the southernmost TH remnant (the Black Mountain region, central Bhutan) has been interpreted as depositional. A depositional contact limits the magnitude of displacement along the early STDS to 10's of km. If the GH-TH contact in the Black Mountain region is instead a discrete shear zone, as observed farther north, displacement on the STDS could be as high as 100's of km. To discriminate between these two interpretations, we determined peak metamorphic P-T conditions through the GH and TH sections, reasoning that a discrete shear zone would produce a distinct jump in metamorphic temperature, pressure or both. Thin section-scale kinematic indicators reveal pervasive top-to-the-north shear from 2-3 km structurally above the Main Central thrust (MCT) through the rest of the 11 km thick GH and TH sections. P-T conditions were determined from immediately above the MCT to 4 km above the GH-TH contact, with 19 samples from the GH, 6 from the overlying Chekha Fm (TH), and 9 from the overlying Maneting Fm (TH). We applied standard Fe-Mg exchange thermometers and Ca net-transfer barometers involving garnet. P-T conditions range from 700 °C and 11 kbar in migmatitic GHS to 600 °C and 8 kbar at the GH-Chekha contact, and 500 °C and 5 kbar at the top of the Maneting. We found no jumps in either temperature or pressure at any level, but a steeper than lithostatic pressure gradient, which we interpret to result from distributed extensional shear. The average thermal

Dynamic contrast-enhanced imaging of the wrist in rheumatoid arthritis: dedicated low-field (0.25-T) versus high-field (3.0-T) MRI

Energy Technology Data Exchange (ETDEWEB)

Lee, Ryan K.L.; Griffith, James F.; Wang, D.F.; Yeung, David K.W. [The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, Prince Of Wales Hospital, Hong Kong, SAR (China); Shi, L. [The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Division of Neurology, Hong Kong, SAR (China); Li, Edmund K.; Tam, L.S. [The Chinese University of Hong Kong, Department of Medicine, Division of Rheumatology, Prince Of Wales Hospital, Hong Kong, SAR (China)

2015-08-15

To compare the assessment of wrist synovitis severity, synovial volume and synovial perfusion parameters on a dedicated low-field (0.25-T) to that of a high-field (3-T) whole-body MR system in patients with rheumatoid arthritis (RA). Twenty-one patients (mean age 50.0 ± 9.8 years) with active RA were recruited prospectively. Dynamic contrast-enhanced MRI examination of the most severely affected wrist was performed at both 0.25 T and 3 T. Three MRI-derived parameters, synovitis severity (RAMRIS grade), synovial volume (ml{sup 3}) and synovial perfusion indices (maximum enhancement and enhancement slope), were compared. Comparing 0.25- and 3-T MRI, there was excellent agreement for semiquantitative assessment (r: 0.80, p < 0.00001) of synovitis (RAMRIS) as well as quantitative assessment (r: 0.94, p < 0.00001) of synovial volume. Good agreement for synovial Emax (r: 0.6, p = 0.002) and fair agreement (r: 0.5, p = 0.02) for synovial Eslope was found. Imaging of the RA wrist at 0.25 T yields excellent correlation with 3 T with regard to the synovitis activity score (RAMRIS) and synovial volume measurement. Fair to good correlation between low- (0.25-T) and high-field (3-T) MR systems was found for perfusion parameters, being better for Emax than for Eslope. (orig.)

Intracellular lipid in papillary renal cell carcinoma (pRCC): T2 weighted (T2W) MRI and pathologic correlation

Energy Technology Data Exchange (ETDEWEB)

Schieda, Nicola; Van der Pol, Christian B.; Moosavi, Bardia; McInnes, Matthew D.F. [The Ottawa Hospital, The University of Ottawa, Department of Medical Imaging, Ottawa, Ontario (Canada); Mai, Kien T.; Flood, Trevor A. [The Ottawa Hospital, The University of Ottawa, Department of Anatomical Pathology, Ottawa, Ontario (Canada)

2015-07-15

To evaluate if pRCCs demonstrate intracellular lipid (i-lipid) at chemical-shift (CS) MRI, and assess T2W-MRI and pathologic characteristics. Sixty-two patients with a pRCC diagnosis underwent MRI over 11 years (IRB-approved). Two radiologists independently assessed for presence of i-lipid on CS-MRI and homogeneity on T2W-MRI. Inter-observer agreement was assessed via an intraclass correlation and results were compared using the Chi-square test. Discordant cases were reviewed to establish consensus. T2W SI-ratios (SI.tumor/SI.kidney) and CS-SI index were compared using independent t-tests and Spearman correlation. Two pathologists re-evaluated the histopathology. Nine of the 62 pRCCs (14.5 %) demonstrated i-lipid; agreement was moderate (ICC = 0.63). Pathology review depicted clear cells in four tumours and foamy histiocytes in five tumours. 25.8-35.4 % (ICC = 0.65) of tumours were homogeneous on T2W-MRI. No pRCC with i-lipid was considered homogeneous (p = 0.01-0.04). Overall, T2W SI-ratio and CS-SI index were 0.89 (±0.29) and -3.63 % (-7.27 to 11.42). pRCC with i-lipid had significantly higher T2W SI-ratio (p = 0.003). There was a correlation between the CS-SI index and T2W SI-ratio, (r = 0.44, p < 0.001). Intracellular lipid is uncommonly detected in pRCCs due to clear cell changes and foamy histiocytes. These tumours are associated with heterogeneously-increased SI in T2W-MRI. (orig.)

P-T phase diagram of a holographic s+p model from Gauss-Bonnet gravity

International Nuclear Information System (INIS)

Nie, Zhang-Yu; Zeng, Hui

2015-01-01

In this paper, we study the holographic s+p model in 5-dimensional bulk gravity with the Gauss-Bonnet term. We work in the probe limit and give the Δ-T phase diagrams at three different values of the Gauss-Bonnet coefficient to show the effect of the Gauss-Bonnet term. We also construct the P-T phase diagrams for the holographic system using two different definitions of the pressure and compare the results.

Hydrogen–Deuterium Exchange and Mass Spectrometry Reveal the pH-Dependent Conformational Changes of Diphtheria Toxin T Domain

Science.gov (United States)

2015-01-01

The translocation (T) domain of diphtheria toxin plays a critical role in moving the catalytic domain across the endosomal membrane. Translocation/insertion is triggered by a decrease in pH in the endosome where conformational changes of T domain occur through several kinetic intermediates to yield a final trans-membrane form. High-resolution structural studies are only applicable to the static T-domain structure at physiological pH, and studies of the T-domain translocation pathway are hindered by the simultaneous presence of multiple conformations. Here, we report the application of hydrogen–deuterium exchange mass spectrometry (HDX-MS) for the study of the pH-dependent conformational changes of the T domain in solution. Effects of pH on intrinsic HDX rates were deconvolved by converting the on-exchange times at low pH into times under our “standard condition” (pH 7.5). pH-Dependent HDX kinetic analysis of T domain clearly reveals the conformational transition from the native state (W-state) to a membrane-competent state (W+-state). The initial transition occurs at pH 6 and includes the destabilization of N-terminal helices accompanied by the separation between N- and C-terminal segments. The structural rearrangements accompanying the formation of the membrane-competent state expose a hydrophobic hairpin (TH8–9) to solvent, prepare it to insert into the membrane. At pH 5.5, the transition is complete, and the protein further unfolds, resulting in the exposure of its C-terminal hydrophobic TH8–9, leading to subsequent aggregation in the absence of membranes. This solution-based study complements high resolution crystal structures and provides a detailed understanding of the pH-dependent structural rearrangement and acid-induced oligomerization of T domain. PMID:25290210

High-resolution whole-brain diffusion MRI at 7T using radiofrequency parallel transmission.

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Wu, Xiaoping; Auerbach, Edward J; Vu, An T; Moeller, Steen; Lenglet, Christophe; Schmitter, Sebastian; Van de Moortele, Pierre-François; Yacoub, Essa; Uğurbil, Kâmil

2018-03-30

Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm 2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx. pTx significantly improved flip-angle detected signal uniformity across the brain, yielding ∼19% increase in temporal SNR (tSNR) averaged over the brain relative to 1Tx. This allowed significantly enhanced estimation of multiple fiber orientations (with ∼21% decrease in dispersion) in HCP-style 7T dMRI datasets. Additionally, pTx pulses achieved substantially lower power deposition, permitting higher accelerations, enabling collection of the same data in 2/3 and 1/2 the scan time or of more data in the same scan time. pTx provides a solution to two major limitations for slice-accelerated high-resolution whole-brain dMRI at 7T; it improves flip-angle uniformity, and enables higher slice acceleration relative to current state-of-the-art. As such, pTx provides significant advantages for rapid acquisition of high-quality, high-resolution truly whole-brain dMRI data. © 2018 International Society for Magnetic Resonance in Medicine.

Existence and multiplicity of homoclinic solutions for p(t-Laplacian systems with subquadratic potentials

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Bin Qin

2014-04-01

Full Text Available By using the genus properties, we establish some criteria for the second-order p(t-Laplacian system $$ \\frac{d}{dt}\\big(|\\dot{u}(t|^{p(t-2}\\dot{u}(t\\big-a(t|u(t|^{p(t-2}u(t +\

Evaluating the Training, Responsibilities, and Practices of P&T Committee Members and Nonmember Contributors.

Science.gov (United States)

Rodriguez, Ryan; Kelly, Brett J; Moody, Mary

2017-08-01

use any criteria for author selection. When authoring documents, primary literature was routinely consulted by 89.5% of the respondents. Most of the respondents (84.1%) used an organization-specific document template, while 5.8% of the respondents indicated that they prepared documents with no defined process. The most highly ranked factor that could have a perceived beneficial effect on P&T committee functions were guidelines on the authoring and reviewing of P&T committee documents. The survey of P&T committee members and nonmember contributors used in this study identified current training, responsibilities, and practices that can inform recommendations for standards in these domains. Findings suggest opportunities for improvement in achieving best practice recommendations to ensure evidence-based decision making by P&T committees. No outside funding supported this study. At the time of this study, Kelly was employed by Global Account Management Group (GAMG), which provides consulting services to the hospital and health services industry. As an employee of GAMG, Kelly has served on various advisory boards. All fees for consulting work were paid to GAMG and were primarily related to training or the federal market (e.g., Department of Defense or the Department of Veterans Affairs) and have no association with this study. Rodriguez and Moody report no conflicts of interest. All authors contributed to study concept and design. Rodriguez took the lead in data collection, assisted by the other authors. Data interpretation was performed by Rodriguez, along with Kelly and Moody. The manuscript was written and revised primarily by Rodriguez, along with the other authors.

P2X7 on mouse T cells: one channel, many functions

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Björn eRissiek

2015-05-01

Full Text Available The P2X7 receptor is an adenosine triphosphate (ATP-gated cation channel that is expressed by several cells of the immune system. P2X7 is best known for its proinflammatory role in promoting inflammasome formation and release of mature IL-1β by innate immune cells. Mounting evidence indicates that P2X7 is also an important regulatory receptor of murine and human T cell functions. Murine T cells express a sensitive splice variant of P2X7 that can be activated either by non-covalent binding of ATP or, in the presence of nicotinamide adenine dinucleotide (NAD+, by its covalent ADP-ribosylation catalyzed by the ecto-ADP-ribosyltransferase ARTC2.2. Prolonged activation of P2X7 by either one of these pathways triggers the induction of T cell death. Conversely, lower concentrations of ATP can activate P2X7 to enhance T cell proliferation and production of IL-2. In this review we will highlight the molecular and cellular consequences of P2X7 activation on mouse T cells and its versatile role in T cell homeostasis and activation. Further, we will discuss important differences in the function of P2X7 on human and murine T cells.

Mercury nonstoichiometry of the Hg1-xBa2CuO4+δ superconductor and the P(Hg)-P(O2)-T phase diagram of the Hg-Ba-Cu-O system

International Nuclear Information System (INIS)

Alyoshin, V.A.; Mikhailova, D.A.; Rudnyi, E.B.; Antipov, E.V.

2002-01-01

The P(Hg)-P(O 2 )-T phase diagram of the Hg-Ba-Cu-O system for the Ba:Cu=2:1 ratio was experimentally studied and followed by means of the thermodynamic modeling. It was shown that the Hg 1-x Ba 2 CuO 4+δ (Hg-1201) superconductor possesses a significant range of Hg-nonstoichiometry and exists in a certain P(Hg), P(O 2 ) and T range. Mercury nonstoichiometry of Hg-1201 was investigated in the 923≤T≤1095 K; 2.0≤P(Hg)≤8.4 atm; 0.09≤P(O 2 )≤0.86 atm ranges. It was found that the mercury content varies in the range of 0.80-0.94 under these conditions. The Gibbs energy of the Hg-1201 phase was estimated as a function of temperature and mercury concentration. The obtained results allow optimizing the synthesis conditions of Hg-1201 with a given Hg-content including preparation of the Hg-stoichiometric phase

Evaluating high pH for control of dreissenid mussels

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Dave Evans

2013-04-01

Full Text Available Two field experiments were carried out using a custom built flow-through laboratory to test the effect of elevated pH on dreissenid musselsas a potential control method. Both experiments tested the ability of dreissenid pediveligers to settle under conditions of elevated pH and thelong-term survival of adult dreissenids under the same conditions. The two experimental sites had different water quality and differentspecies of dreissenids present. The settlement of quagga mussel pediveligers at the lower Colorado River was inhibited with increasing pH.At the maximum achieved pH of 9.1, there was approximately 90% reduction compared to the maximum settlement observed in the controls.Since the settlement was almost as low in pH 8.9 as at pH 9.1, the inhibition in settlement may have been due to the presence of a precipitateformed under high pH conditions rather than the increase in background pH. No mortality of quagga mussel adults was observed in theexperimental pH levels at the lower Colorado River. At San Justo Reservoir, zebra mussel settlement decreased with increasing pH. Newsettlement was almost entirely absent at the highest pH tested (pH 9.6. The observed mortality of adult zebra mussels was low, but did tendto increase with increasing pH. We also tested the response of adult zebra mussels to short-term exposure to very high pH levels (i.e. pH 10,11, and 12. Adult mussels in poor physical condition experienced 90% mortality after 12 hours at pH 12. For unstressed adult zebra mussels,90% mortality was reached after 120 hours at pH 12. Significant mortalities were also observed both at pH 10 and pH 11. From this study,we conclude that pH elevation could be used both as a preventative treatment to eliminate settlement by dreissenid mussels and as an end ofseason treatment to eliminate adults. The high pH treatment would have to be tailored to the site water quality to prevent formation ofprecipitate during treatment and to minimize corrosive

Meiotic and pedigree segregation analyses in carriers of t(4;8)(p16;p23.1) differing in localization of breakpoint positions at 4p subband 4p16.3 and 4p16.1.

Science.gov (United States)

Midro, Alina T; Zollino, Marcella; Wiland, Ewa; Panasiuk, Barbara; Iwanowski, Piotr S; Murdolo, Marina; Śmigiel, Robert; Sąsiadek, Maria; Pilch, Jacek; Kurpisz, Maciej

2016-02-01

The purpose of this study was to compare meiotic segregation in sperm cells from two carriers with t(4;8)(p16;p23.1) reciprocal chromosome translocations (RCTs), differing in localization of the breakpoint positions at the 4p subband-namely, 4p16.3 (carrier 1) and 4p16.1 (carrier 2)-and to compare data of the pedigree analyses performed by direct method. Three-color fluorescent in situ hybridization (FISH) on sperm cells and FISH mapping for the evaluation of the breakpoint positions, data from pedigrees, and direct segregation analysis of the pedigrees were performed. Similar proportions of normal/balanced and unbalanced sperm cells were found in both carriers. The most common was an alternate type of segregation (about 52 % and about 48 %, respectively). Unbalanced adjacent I and adjacent II karyotypes were found in similar proportions about 15 %. The direct segregation analysis (following Stengel-Rutkowski) of the pedigree of carriers of t(4;8)(p16.1;p23.1) was performed and results were compared with the data of the pedigree segregation analysis obtained earlier through the indirect method. The probability of live-born progeny with unbalanced karyotype for carriers of t(4;8)(p16.1;p23.1) was moderately high at 18.8 %-comparable to the value obtained using the indirect method for the same carriership, which was 12 %. This was, however, markedly lower than the value of 41.2 % obtained through the pedigree segregation indirect analysis estimated for carriers of t(4;8)(p16.3;p23.1), perhaps due to the unique composition of genes present within the 4p16.1-4p 16.3 region. Revealed differences in pedigree segregation analysis did not correspond to the very similar profile of meiotic segregation patterns presented by carrier 1 and carrier 2. Most probably, such discordances may be due to differences in embryo survival rates arising from different genetic backgrounds.

Conditional IL-2 gene deletion: consequences for T cell proliferation

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Kendall A Smith

2012-05-01

Full Text Available To explore the role of interleukin-2 (IL-2 in T cell proliferation, and to circumvent the IL-2 deficiency autoimmune syndrome of conventional il2 gene deletion, mice were created to allow conditional il2 gene deletion when treated with the estrogen analogue, tamoxifen (TAM as adults. Splenocytes from four different mouse strains, C57Bl/6 wild type (WT, conventional IL-2 (-/-, TAM-treated Cre recombinase negative (Cre-/IL2fl/fl, and Cre+/IL-2fl/fl (Cre+, were activated with anti-CD3 and anti-CD28, and monitored for CD4+ and CD8+ T cell lymphocyte blastogenesis, aerobic glycolysis, BrdU incorporation into newly synthesized DNA, and CFSE dye dilution to monitor cell division. IL-2 production was monitored by quantitative ELISA and multiple additional cytokines were monitored by protein-bead arrays. Splenocytes from conventional IL-2 (-/- and TAM-treated Cre+ mice resulted in undetectable IL-2 production, so that both strains were IL-2 deficient. As monitored by flow cytometry, activated CD4+ and CD8+ T cells from WT, Cre+ and Cre- mice all underwent blastogenesis, whereas far fewer cells from conventional IL-2 (-/- mice did so. By comparison, only cells from IL-2 sufficient WT and Cre- switched to aerobic glycolysis as evidenced by a drop in media pH. Blastogenesis was mirrored by BrdU incorporation and CFSE dye dilution by CD4+ and CD8+ T cells from WT, Cre+ and Cre- mice, which were all equivalent, while proliferation of cells from conventional IL-2 (-/- mice was compromised. Splenocytes from IL-2 deficient conventional IL-2 (-/- mice produced low or undetectable other γc-chain cytokines (IL-4, IL-7, IL-9, IL-13, IL-15, and IL-21, whereas production of these γc-chain cytokines from IL-2-deficient conditional IL-2 (-/- Cre+ mice were comparable with WT and Cre- mice. These results indicate that CD4+ and CD8+ T cell blastogenesis cannot be attributable to IL-2 alone, but a switch to aerobic glycolysis is attributable to IL-2, and proliferation

Highly luminescent InP/GaP/ZnS QDs emitting in the entire color range via a heating up process.

Science.gov (United States)

Park, Joong Pill; Lee, Jae-Joon; Kim, Sang-Wook

2016-07-20

InP-based quantum dots (QDs) have attracted much attention for use in optical applications, and several types of QDs such as InP/ZnS, InP/ZnSeS, and InP/GaP/ZnS have been developed. However, early synthetic methods that involved rapid injection at high temperatures have not been able to reproducibly produce the required optical properties. They were also not able to support commercialization efforts successfully. Herein, we introduce a simple synthetic method for InP/GaP/ZnS core/shell/shell QDs via a heating process. The reaction was completed within 0.5 h and a full color range from blue to red was achieved. For emitting blue color, t-DDT was applied to prevent particle growth. From green to orange, color variation was achieved by adjusting the quantity of myristic acid. Utilizing large quantities of gallium chloride led to red color. With this method, we produced high-quality InP/GaP/ZnS QDs (blue QY: ~40%, FWHM: 50 nm; green QY: ~85%, FWHM: 41 nm; red QY: ~60%, FWHM: 65 nm). We utilized t-DDT as a new sulfur source. Compared with n-DDT, t-DDT was more reactive, which allowed for the formation of a thicker shell.

Highly luminescent InP/GaP/ZnS QDs emitting in the entire color range via a heating up process

Science.gov (United States)

Park, Joong Pill; Lee, Jae-Joon; Kim, Sang-Wook

2016-07-01

InP-based quantum dots (QDs) have attracted much attention for use in optical applications, and several types of QDs such as InP/ZnS, InP/ZnSeS, and InP/GaP/ZnS have been developed. However, early synthetic methods that involved rapid injection at high temperatures have not been able to reproducibly produce the required optical properties. They were also not able to support commercialization efforts successfully. Herein, we introduce a simple synthetic method for InP/GaP/ZnS core/shell/shell QDs via a heating process. The reaction was completed within 0.5 h and a full color range from blue to red was achieved. For emitting blue color, t-DDT was applied to prevent particle growth. From green to orange, color variation was achieved by adjusting the quantity of myristic acid. Utilizing large quantities of gallium chloride led to red color. With this method, we produced high-quality InP/GaP/ZnS QDs (blue QY: ~40%, FWHM: 50 nm green QY: ~85%, FWHM: 41 nm red QY: ~60%, FWHM: 65 nm). We utilized t-DDT as a new sulfur source. Compared with n-DDT, t-DDT was more reactive, which allowed for the formation of a thicker shell.

A high-resolution study of the sup 20 Ne( sup 3 He,t) sup 20 Na reaction and the sup 19 Ne(p,. gamma. ) sup 20 Na reaction rate

Energy Technology Data Exchange (ETDEWEB)

Smith, M S; Magnus, P V; Hahn, K I; Howard, A J; Parker, P D [A.W. Wright Nuclear Structure Lab., Yale Univ., New Haven, CT (United States); Champagne, A E; Mao, Z Q [Dept. of Physics, Princeton Univ., NJ (United States)

1992-01-13

A high-precision measurement of the {sup 20}Ne({sup 3}He,t){sup 20}Na reaction has been made using implanted {sup 20}Ne transmission targets to obtain pertinent information on the low-energy resonances in the {sup 19}Ne(p,{gamma}){sup 20}Na reaction. Resonance energies (447{+-}5, 658{+-}5, 787{+-}5, and 857{+-}5 keV) and upper limits on total intrinsic widths (<10, <6, <10, and <16 keV) have been measured for four excited states above the 2.199 MeV proton threshold in {sup 20}Na. The stellar {sup 19}Ne(p,{gamma}){sup 20}Na reaction rate is calculated for temperatures between 1x10{sup 8} and 1x10{sup 9} K. When combined with a recent study of the {sup 15}O({alpha},{gamma}){sup 19}Ne reaction, a new estimate is made of the conditions required for breakout from the Hot CNO cylce to the rapid proton capture process. (orig.).

Exit Strategies: S1P Signaling and T Cell Migration.

Science.gov (United States)

Baeyens, Audrey; Fang, Victoria; Chen, Cynthia; Schwab, Susan R

2015-12-01

Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egress and the regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis are increasingly well understood, much remains to be learned about S1P signaling and distribution during an immune response. Recent data suggest that the role of S1PR1 in directing cells from tissues into circulatory fluids is reprised again and again, particularly in guiding activated T cells from non-lymphoid tissues into lymphatics. Conversely, S1P receptor 2 (S1PR2), which antagonizes migration towards chemokines, confines cells within tissues. Here we review the current understanding of the roles of S1P signaling in activated T cell migration. In this context, we outline open questions, particularly regarding the shape of S1P gradients in different tissues in homeostasis and inflammation, and discuss recent strategies to measure S1P. Copyright © 2015 Elsevier Ltd. All rights reserved.

Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

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Hitsumoto T

2015-03-01

Full Text Available Takashi Hitsumoto,1 Kohji Shirai2 1Hitsumoto Medical Clinic, Yamaguchi, Japan; 2Department of Vascular Function (donated, Sakura Hospital, Toho University School of Medicine, Chiba, Japan Purpose: The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT], measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients. Patients and methods: We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome. Results: There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01, blood concentrations of brain natriuretic peptide (P<0.01, reactive oxygen metabolites (markers of oxidative stress, P<0.001, and the cardio–ankle vascular index (marker of arterial function, P<0.01. Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor. Conclusion: The findings of this study indicate that in vivo oxidative stress and abnormality of arterial function are closely associated with an increase in hs-cTnT concentrations in Japanese metabolic syndrome patients. Keywords: troponin, metabolic syndrome, risk factor, oxidative stress, cardio–ankle vascular index

Evaluation of the effect of Ni-P coating on the corrosion resistance of the aluminium 7075 T6 alloy

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Gil, L.

2008-02-01

Full Text Available The aluminum alloy 7075-T6 is a structural alloy widely used for aeronautical applications due to its high relationship between mechanical resistance and weight. Depending upon the environmental conditions, many types of corrosion mechanisms such as intergranular, exfoliation, have been found to occur in aircraft structural aluminum alloys. A significant advance in order to improve the behavior of this alloy is related to the application of the autocatalytic Ni-P coating which confers an excellent corrosion resistance coupled with both reduced erosive wear and higher hardness. The purpose of this work was to investigate the effect of the application of a Ni-P coating on the corrosion resistance of an aluminum 7075-T6 alloy. The results obtained indicated that the application of the Ni-P coatings diminishes the susceptibility to pitting and makes the aluminum 7075 T6 alloy immune to the exfoliation corrosion attack.

La aleación de aluminio 7075-T6 es una aleación estructural ampliamente utilizada para aplicaciones aeronáuticas, debido a su alta relación entre resistencia mecánica y peso. Dependiendo de las condiciones ambientales, algunos mecanismos de corrosion tales como intergranular, exfoliacion, picadura y crevice se ha encontrado que ocurren en estructuras de aviones de aleaciones de aluminio. Un avance siginificativo para mejorar el comportamiento de esta aleación es la aplicación de recubrimientos autocatalíticos de Ni-P, los cuales confieren una excelente resistencia a la corrosión acoplado con una reducción del desgaste erosivo y un aumento de la dureza. El propósito de este trabajo fue investigar el efecto de la aplicación de un recubrimiento de Ni-P sobre la resistencia a la corrosión de una aleación de aluminio 7075-T6. Los resultados obtenidos indican que la aplicación del recubrimiento de Ni-P disminuye la susceptibilidad a la picadura y hace a la aleación de aluminio 7075 T6, prácticamente inmune al ataque

Boundary conditions in Ginsburg-Landau theory and critical temperature of high-Tc superconductors

International Nuclear Information System (INIS)

Lykov, A.N.

2008-01-01

New mixed boundary conditions to the Ginsburg-Landau equations are found to limit the critical temperature (T c ) of high-T c superconductors. Moreover, the value of the pseudogap in these superconductors can be explained by using the method. As a result, the macroscopic approach is proposed to increase T c of cuprate superconductors

pYEMF, a pUC18-derived XcmI T-vector for efficient cloning of PCR products.

Science.gov (United States)

Gu, Jingsong; Ye, Chunjiang

2011-03-01

A 1330-bp DNA sequence with two XcmI cassettes was inserted into pUC18 to construct an efficient XcmI T-vector parent plasmid, pYEMF. The large size of the inserted DNA fragment improved T-vector cleavage efficiency, and guaranteed good separation of the molecular components after restriction digestion. The pYEMF-T-vector generated from parent plasmid pYEMF permits blue/white colony screening; cloning efficiency analysis showed that most white colonies (>75%) were putative transformants which carried the cloning product. The sequence analysis and design approach presented here will facilitate applications in the fields of molecular biology and genetic engineering.

Microsoft excel spreadsheets for calculation of P-V-T relations and thermodynamic properties from equations of state of MgO, diamond and nine metals as pressure markers in high-pressure and high-temperature experiments

Science.gov (United States)

Sokolova, Tatiana S.; Dorogokupets, Peter I.; Dymshits, Anna M.; Danilov, Boris S.; Litasov, Konstantin D.

2016-09-01

We present Microsoft Excel spreadsheets for calculation of thermodynamic functions and P-V-T properties of MgO, diamond and 9 metals, Al, Cu, Ag, Au, Pt, Nb, Ta, Mo, and W, depending on temperature and volume or temperature and pressure. The spreadsheets include the most common pressure markers used in in situ experiments with diamond anvil cell and multianvil techniques. The calculations are based on the equation of state formalism via the Helmholtz free energy. The program was developed using Visual Basic for Applications in Microsoft Excel and is a time-efficient tool to evaluate volume, pressure and other thermodynamic functions using T-P and T-V data only as input parameters. This application is aimed to solve practical issues of high pressure experiments in geosciences and mineral physics.

A fully liquid DTaP-IPV-HB-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Turkish infants and toddlers

Science.gov (United States)

Ceyhan, Mehmet; Yıldırım, İnci; Tezer, Hasan; Devrim, İlker; Feroldi, Emmanuel

2017-08-23

Background/aim: Immunogenicity and safety of a primary series of a fully liquid, hexavalent DTaP-IPV-HB-PRP-T vaccine given at 2, 3, and 4 months of age compared to licensed comparators and a DTaP-IPV-HB-PRP-T booster at 15?18 months were evaluated. Materials and methods: This was a Phase III, randomized, open-label trial. Primary series (no hepatitis B [HB] at birth) of DTaP-IPV-HB-PRP-T (N = 155) (group 1) or licensed control vaccines (DTaP-IPV//PRP-T and standalone HB: N = 155) (group 2) and DTaP-IPV-HB-PRP-T booster were administered. Noninferiority was evaluated 1 month postprimary series for anti-HB seroprotection (SP). All other analyses were descriptive. Safety was assessed from parental reports. Results: Postprimary series noninferiority of anti-HB ≥ 10 mIU/mL was demonstrated for the DTaP-IPV-HB-PRP-T vaccine (94.0%) compared to the licensed control (96.1%). Postprimary series primary SP and seroconversion (SC) rates were high and similar for both groups. Antibody persistence (prebooster) was high for each antigen and similar between groups except for HB, which was lower for DTaP-IPV-HB-PRP-T than for standalone HB. For each antigen except HB, DTaP-IPV-HB-PRP-T booster responses were high and similar in each group. Safety was good for primary and booster series and similar between groups. Conclusion: The DTaP-IPV-HB-PRP-T vaccine is immunogenic and safe when administered in a challenging primary series schedule without HB vaccination at birth.

Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

Directory of Open Access Journals (Sweden)

Humberto Andres Vaz

2016-04-01

Full Text Available Abstract Background: The kinetics of high-sensitivity troponin T (hscTnT release should be studied in different situations, including functional tests with transient ischemic abnormalities. Objective: To evaluate the release of hscTnT by serial measurements after exercise testing (ET, and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Methods: Patients with acute ST-segment elevation myocardial infarction (STEMI undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT0h, 2 (TnT2h, 5 (TnT5h, and 8 hours (TnT8h after ET. The outcomes were peak hscTnT, TnT5h/TnT0h ratio, and the area under the blood concentration-time curve (AUC for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT0h, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance. Results: This study included 95 patients. The highest geometric means were observed at 5 hours (TnT5h. After adjustments, peak hscTnT, TnT5h/TnT0h and AUC were 59% (p = 0.002, 59% (p = 0.003 and 45% (p = 0.003 higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Conclusion: Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

Energy Technology Data Exchange (ETDEWEB)

Vaz, Humberto Andres, E-mail: humbertovaz@cardiol.br; Vanz, Ana Paula; Castro, Iran [Instituto de Cardiologia - Fundação Universitária de Cardiologia, Porto Alegre, RS (Brazil)

2016-04-15

The kinetics of high-sensitivity troponin T (hscTnT) release should be studied in different situations, including functional tests with transient ischemic abnormalities. To evaluate the release of hscTnT by serial measurements after exercise testing (ET), and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT{sub 0h}), 2 (TnT{sub 2h}), 5 (TnT{sub 5h}), and 8 hours (TnT{sub 8h}) after ET. The outcomes were peak hscTnT, TnT{sub 5h}/TnT{sub 0h} ratio, and the area under the blood concentration-time curve (AUC) for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT{sub 0h}, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance). This study included 95 patients. The highest geometric means were observed at 5 hours (TnT{sub 5h}). After adjustments, peak hscTnT, TnT{sub 5h}/TnT{sub 0h} and AUC were 59% (p = 0.002), 59% (p = 0.003) and 45% (p = 0.003) higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

P and T research program in Korea

International Nuclear Information System (INIS)

Park, C. K.

1997-01-01

The national energy demand is taking a sharp rise on account of the rapid growth of economy in Korea. Unfortunately, Korea has not much choice of alternative energy a promising option for Korea. For instance, eleven nuclear plants are in operation and 7 plants are under construction. Several plants are in planning stage. KAERI has played a major role in the design and operation of the plants in Korea. The spent fuel issue is calling for acute attention nationwide as the number of plants increases. Korea is actively seeking a technical solution to that problem surfacing on the horizon. A preliminary conceptual study on the P and T technology was performed from 1992 to 1996 and the future research directions were derived from that study. Because of the situation Korea is facing with, one of the major technical guidelines is that the P and T technology should be developed in compliance with the NPT. The concept of an accelerator driven subcritical system was found to be the most favorable option according to the conceptual study. KAERI set up an ambitious accelerator driven system development program for next 10 years. Key elementary technologies for a high current accelerator and a subcritical system are scheduled to be developed and experimented for the first five years (1997-2001). For the second five years (2002-2006), the accelerator program is pushed for the completion to parameters of 1 GeV, 20mA with capability to drive a subcritical system. For the subcritical system, a detail design study is to be performed and a small mockup system is to be built for bench scale test purpose

Measurement of the jet mass in highly boosted t anti t events from pp collisions at √(s) = 8 TeV

Energy Technology Data Exchange (ETDEWEB)

Sirunyan, A.M.; Tumasyan, A. [Yerevan Physics Institute, Yerevan (Armenia); Adam, W. [Institut fuer Hochenergiephysik, Wien (Austria); Collaboration: CMS Collaboration; and others

2017-07-15

The first measurement of the jet mass m{sub jet} of top quark jets produced in t anti t events from pp collisions at √(s) = 8 TeV is reported for the jet with the largest transverse momentum p{sub T} in highly boosted hadronic top quark decays. The data sample, collected with the CMS detector, corresponds to an integrated luminosity of 19.7 fb{sup -1}. The measurement is performed in the lepton+jets channel in which the products of the semileptonic decay t → bW with W → lν where l is an electron or muon, are used to select t anti t events with large Lorentz boosts. The products of the fully hadronic decay t → bW with W → q anti q{sup '} are reconstructed using a single Cambridge-Aachen jet with distance parameter R = 1.2, and p{sub T} > 400 GeV. The t anti t cross section as a function of m{sub jet} is unfolded at the particle level and is used to test the modelling of highly boosted top quark production. The peak position of the m{sub jet} distribution is sensitive to the top quark mass m{sub t}, and the data are used to extract a value of m{sub t} to assess this sensitivity. (orig.)

Two- and three-particle azimuthal correlations of high-p{sub t} charged hadrons in Pb+Au collisons at 158 GeV per nucleon

Energy Technology Data Exchange (ETDEWEB)

Kniege, Stefan

2009-07-14

An essential goal of physics with heavy ions is the study of the state of nuclear matter at high densities respectively temperatures. Such states can be generated and studied by collisions of high-energetic heavy ions in particle accelerators like the Super Proton Synchrotron SPS at the European nuclear research center CERN in Geneve. The present thesis deals with the analysis of the influence of the medium generated in such a collision on high-energetic particles, which pass this medium. For this correlations between particles with high transverse momentum p{sub t} as function of the centrality of the collisions and the charge of the contributing particles are studied. Aim is to establish an experimental base for the theoretical description of the properties of the medium in such collisions. [German] Ein wesentliches Ziel der Physik mit schweren Ionen ist die Untersuchung der Zustaende von Kernmaterie bei hohen Dichten bzw. Temperaturen. Solche Zustaende lassen sich durch Kollisionen von hochenergetischen schweren Ionen in Teilchenbeschleunigern wie dem Super Proton Synchrotron SPS am Europaeischen Kernforschungszentrum CERN in Genf erzeugen und untersuchen. Die vorliegende Arbeit beschaeftigt sich mit der Analyse des Einflusses des in einer solchen Kollision erzeugten Mediums auf hochenergetische Teilchen, welche dieses Medium durchqueren. Hierzu werden Korrelationen zwischen Teilchen mit hohem Transversalimpuls p{sub t} als Funktion der Zentralitaet der Kollisionen und der Ladung der beteiligten Teilchen untersucht. Ziel ist es, hierdurch eine experimentelle Grundlage fuer die theoretische Beschreibung der Eigenschaften des Mediums in solchen Kollisionen bereitzustellen. (orig.)

A measurement of t$\\bar{t}$ production cross section in p$\\bar{p}$ collisions at √s = 1.8 TeV using neural networks

Energy Technology Data Exchange (ETDEWEB)

Singh, Harpreet [Univ. of California, Riverside, CA (United States)

1999-12-01

The authors present the results of a new measurement of the t$\\bar{t}$ production cross section using eμ channel in p$\\bar{p}$ collisions at √s = 1.8 TeV. This study corresponds to an integrated luminosity of 108.3 ± 5.7 pb^-1 acquired by the D0 detector during the Fermilab Tevatron Collider Run 1 (1992--1996). By using neural network techniques instead of the conventional analysis methods, the authors show that the signal acceptance can be increased by 10% (for m_t = 172 GeV/c²) while the background remains constant. Four eμ events are observed in data with an estimated background of 0.22 ± 0.14 corresponding to a t$\\bar{t}$ production cross section of 9.75 ± 5.53 pb.

Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

Science.gov (United States)

Stepchenkova, Elena I.; Tarakhovskaya, Elena R.; Spitler, Kathryn; Frahm, Christin; Menezes, Miriam R.; Simone, Peter D.; Kolar, Carol; Marky, Luis A.; Borgstahl, Gloria E. O.; Pavlov, Youri I.

2009-01-01

Sanitization of the cellular nucleotide pools from mutagenic base analogs is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic and toxic incorporation of purine base analogs (i.e. ITP, dITP, XTP, dXTP or 6-hydroxyaminopurine (HAP) deoxynucleoside triphosphate) into nucleic acids is prevented by inosine triphosphate pyrophosphatase (ITPA). The ITPA gene is a highly conserved, moderately expressed gene. Defects in ITPA orthologs in model organisms cause severe sensitivity to HAP and chromosome fragmentation. A human polymorphic allele 94C->A encodes for the enzyme with a P32T amino acid change and leads to accumulation of non-hydrolyzed ITP. ITPase activity is not detected in erythrocytes of these patients. The P32T polymorphism has also been associated with adverse sensitivity to purine base analog drugs. We have found that the ITPA-P32T mutant is a dimer in solution, as is wild-type ITPA, and has normal ITPA activity in vitro, but the melting point of ITPA-P32T is 5 degrees C lower than that of wild-type. ITPA-P32T is also fully functional in vivo in model organisms as determined by a HAP mutagenesis assay and its complementation of a bacterial ITPA defect. The amount of ITPA protein detected by western blot is severely diminished in a human fibroblast cell line with the 94C->A change. We propose that the P32T mutation exerts its effect in certain human tissues by cumulative effects of destabilization of transcripts, protein stability and availability. PMID:19631656

Low pT muons in b-jets in ATLAS TILECAL

International Nuclear Information System (INIS)

Bosman, M.; Budagov, Yu.A.; Pantea, D.

1995-01-01

ATLAS Tile Calorimeter possibilities to identify b-jets that contain low p T muons are investigated. This is made in order to extend the capability of b-tagging through muon b-quark semileptonic decays beyond the muon detector limits of efficient registration. Results obtained by Monte Carlo simulation of single isolated jets in ATLAS detector indicate that for b-jets that contain low p T muons in the range 2 T < 5 GeV, one can separate them from light quark or gluon jets. 3 refs., 11 figs

Study on growth condition of Trichoderma mutants

International Nuclear Information System (INIS)

Chen Jian'ai; Xiao Min; Wang Weiming; Chen Weijing; Sun Yongtang

2002-01-01

Some Trichoderma mutants were cultured under different conditions 4 strains, T5, T0803, T1010, T1003 were selected with different mediums and every medium was mixed with fungicide of 40 ppm. The fungicides were procymidone + chlorothalonil, maneb and phosethyl-Al. The pH of medium were 5, 6, 7 and 8, respectively. The growing temperatures were 15, 20, 25 and 30 degree C, respectively. After the hypha growing for some days under natural high temperature, they were put in low temperature for producing spores. The growing times for these hypha were 3,4,5 and 6 days, respectively. All dates were analyzed on statistics with the orthogonal array and ranges (R) were different with different factor and levels (R = 40.4, 42.4, 48.0, 62.8, 107.0). The results showed that the strain was the most influent condition (R = 107.0) and the changed temperature time from high to low was the least influent condition (R = 40.4). Each factor variance was significant and A 3 b 4 C 2 D 1 E 3 was the optimum combined condition, under which T1010 grew more quickly and produced the most spores

Physics of high performance JET plasmas in D-T

International Nuclear Information System (INIS)

2001-01-01

JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB ''Gas Box'' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling ''Wind Tunnel'' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in

Physics of high performance jet plasmas in D-T

International Nuclear Information System (INIS)

1999-01-01

JET has recently operated with deuterium-tritium (D-T) mixtures, carried out an ITER physics campaign in hydrogen, deuterium, D-T and tritium, installed the Mark IIGB 'Gas Box' divertor fully by remote handling and started physics experiments with this more closed divertor. The D-T experiments set records for fusion power (16.1 MW), ratio of fusion power to plasma input power (0.62, and 0.95±0.17 if a similar plasma could be obtained in steady-state) and fusion duration (4 MW for 4 s). A large scale tritium supply and processing plant, the first of its kind, allowed the repeated use of the 20 g tritium on site to supply 99.3 g of tritium to the machine. The H-mode threshold power is significantly lower in D-T, but the global energy confinement time is practically unchanged (no isotope effect). Dimensionless scaling 'Wind Tunnel' experiments in D-T extrapolate to ignition with ITER parameters. The scaling is close to gyroBohm, but the mass dependence is not correct. Separating the thermal plasma energy into core and pedestal contributions could resolve this discrepancy (leading to proper gyroBohm scaling for the core) and also account for confinement degradation at high density and at high radiated power. Four radio frequency heating schemes have been tested successfully in D-T, showing good agreement with calculations. Alpha particle heating has been clearly observed and is consistent with classical expectations. Internal transport barriers have been established in optimised magnetic shear discharges for the first time in D-T and steady-state conditions have been approached with simultaneous internal and edge transport barriers. First results with the newly installed Mark IIGB divertor show that the in/out symmetry of the divertor plasma can be modified using differential gas fuelling, that optimised shear discharges can be produced, and that krypton gas puffing is effective in restoring L-mode edge conditions and establishing an internal transport barrier in such

The effect of Candida albicans on the expression levels of toll-like receptor 2 and interleukin-8 in HaCaT cells under High- and Low-glucose conditions

Directory of Open Access Journals (Sweden)

Di Wang

2018-01-01

Full Text Available Background: The diabetics are prone to skin infections, especially with Candida albicans. It is important to elucidate the different antifungal abilities of patients with hyperglycemia and healthy controls for the treatment of this condition. The toll-like receptor 2 (TLR2 and interleukin (IL-8 secreted by keratinocytes counteract C. albicans. Aim: This study aims to explore the differential expression of toll-like receptor 2 (TLR2 and interleukin (IL-8 secretion by keratinocytes between controls and diabetic patients when challenged with C. albicans. Materials and Methods: HaCaT cells were cultured in high-glucose (HG Dulbecco's modified Eagle's medium (DMEM and low-glucose (LG DMEM. Then, they were exposed to C. albicans hyphae for 24 h. The expression levels of TLR2 and IL-8 were determined at different periods in both the HG and LG groups. Real-time polymerase chain reaction analysis, western blotting, and enzyme-linked immunosorbent assays were performed in this study. The morphological changes of HaCaT cells under two different glucose concentrations were also observed. Results: We found that the expression levels of both TLR2 and IL-8 increased and then decreased in the two groups. Notably, the IL-8 levels in the LG group were higher than those in the HG group at each time point (P<0.05, and the TLR2 levels in the LG group were higher than those in the HG group at the beginning of the experiment and after 24 h of treatment with C. albicans (P<0.05. In each group, the levels of IL-8 and TLR2 at the secretion peak were significantly different from those in the initial and the last period of observation (P<0.05. The cellular morphology of HaCaT cells treated with different concentrations of glucose was also similar. However, with prolonged coculture time, cell death increased. Conclusion: These observations showed that TLR2 and IL-8 act on the keratinocytes interacting with C. albicans, and HG status might affect the function of HaCaT cells

Regulation of the pT181 encoded tetracycline resistance gene in Straphylococcus aureus

International Nuclear Information System (INIS)

Mojumdar, M.

1986-01-01

pT181 is a naturally-occurring 4437 basepair (bp) plasmid isolated from Staphylococcus aureus which encodes inducible resistance to tetracycline (Tc). The DNA sequence data has identified three open reading frames (ORFs). The largest ORF B, has been found to be responsible for the Tc resistance phenotype of pT181. Since most Tc resistance systems appear to be regulated by an effector protein and a repressor protein, several Bal 31 deletion mutants of pT181 were constructed and analyzed in an effort to identify the elements involved in Tc resistance. Two transcomplementing groups of mutants were identified within the tet gene. The mechanism of Tc resistance was studied by assaying the accumulation of [7- 3 H] Tc by Tc sensitive cells, and uninduced and induced pT181-containing cells. A sharp decrease in accumulation of the drug after an initial increase was observed in Tc induced pT181-containing cells. In vivo labeling of Bacillus subtilis minicells containing pT181 was performed with 35 S-methionine to identify the polypeptide product of the tet gene. A Tc-inducible protein having a molecular weight of approximately 50,000 daltons was detected only in B. subtilis minicells carrying pT181. Cell fractionation studies of S. aureus cells with and without pT181 showed that an approximately 28,000 daltons Tc-inducible protein was present in membranes of pT181 containing cells. The amount of TET protein in Tc induced minicells was about fifteen-fold higher than that in uninduced minicells. RNA prepared from stationary phase cells analyzed by Northern blot hybridization showed that the steady-state level of the tet mRNA in induced pT181-containing cells was bout four-fold higher than that in uninduced pT181-containing cells. When RNA synthesis was blocked with rifampicin, tet mRAN was found to be much more stable in Tc induced cells as compared to that in uninduced cells over a 30 min period

Nonrestoration of spontaneously broken P, CP and PQ at high temperature

International Nuclear Information System (INIS)

Dvali G.; Melfo, A.; Senjanovic, G.

1996-01-01

The possibility of P and CP violation at high temperature in models where these symmetries are spontaneously broken is investigated. It is found that in minimal models that include singlet fields, high T nonrestoration is possible for a wide range of parameters of the theory, in particular in models of CP violation with a CP-odd Higgs field. The same holds true for the invisible axion version of the Peccei-Quinn mechanism. This can provide both a way out for the domain wall problem in these theories and the CP violation required for baryogenesis. In the case of spontaneous P violation it turns out that high T nonrestoration required going beyond the minimal model. The results are shown to hold true when next-to-leading order effects are considered. (author). 33 refs, 3 figs

Importance of the High-Expression of Proline Transporter PutP to the Adaptation of Escherichia coli to High Salinity.

Science.gov (United States)

Sasaki, Hideaki; Sato, Daichi; Oshima, Akinobu

2017-01-01

　The effect of the amount of the proline transporter PutP expression on the mechanism of adaptation of E. coli cells to high salinity was analyzed. The PutP gene derived from the E. coli expression plasmid was introduced into the E. coli cell, and a high PutP expression strain was developed. At 1.2 M NaCl culture condition, the growth of normal E. coli cells was inhibited, whereas high ProP expression cells showed growth under 2.5 M NaCl conditions. The uptake of proline by E. coli as a compatible solute and substrate for metabolization was in good accordance with those seen in cell growth. These data suggested that the amount of the proline transporter PutP expression played an important role in the adaptation of E. coli cells to high saline conditions.

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.

Science.gov (United States)

Mendoza, Alejandra; Fang, Victoria; Chen, Cynthia; Serasinghe, Madhavika; Verma, Akanksha; Muller, James; Chaluvadi, V Sai; Dustin, Michael L; Hla, Timothy; Elemento, Olivier; Chipuk, Jerry E; Schwab, Susan R

2017-06-01

Effective adaptive immune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly identifying almost any foreign peptide. Because the production of T cells declines with age, naive T cells must be long-lived. However, it remains unclear how naive T cells survive for years while constantly travelling. The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer's patches, where T cells search for antigens. The concentration of S1P is higher in circulatory fluids than in lymphoid organs, and the S1P 1 receptor (S1P 1 R) directs the exit of T cells from the spleen into blood, and from lymph nodes and Peyer's patches into lymph. Here we show that S1P is essential not only for the circulation of naive T cells, but also for their survival. Using transgenic mouse models, we demonstrate that lymphatic endothelial cells support the survival of T cells by secreting S1P via the transporter SPNS2, that this S1P signals through S1P 1 R on T cells, and that the requirement for S1P 1 R is independent of the established role of the receptor in guiding exit from lymph nodes. S1P signalling maintains the mitochondrial content of naive T cells, providing cells with the energy to continue their constant migration. The S1P signalling pathway is being targeted therapeutically to inhibit autoreactive T cell trafficking, and these findings suggest that it may be possible simultaneously to target autoreactive or malignant cell survival.

Effects of Transcutaneous Vagus Nerve Stimulation (tVNS on the P300 and Alpha-Amylase Level: A Pilot Study

Directory of Open Access Journals (Sweden)

Carlos Ventura-Bort

2018-06-01

Full Text Available Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS, which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants while performing a visual oddball task. During stimulation, oval non-targets (standard, normal-head (easy and rotated-head (difficult targets, as well as novel stimuli (scenes were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult targets produced larger P3b (but not P3a amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool.

Glycogen synthase kinase 3-{beta} phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

Energy Technology Data Exchange (ETDEWEB)

Han, Xiangzi [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Department of Preventive Medicine, Yanbian University College of Medicine, Yanji (China); Ju, Ji-hyun [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Shin, Incheol, E-mail: incheol@hanyang.ac.kr [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of)

2012-06-29

Highlights: Black-Right-Pointing-Pointer Novel S/T-P-S/T domains were identified in NICD. Black-Right-Pointing-Pointer Phosphorylation of NICD on the S/T-P-S/T domains induced nuclear localization. Black-Right-Pointing-Pointer GSK-3{beta} phosphorylated S and T residues in NICD S/T-P-S/T domains. -- Abstract: We identified two S/T-P-S/T domains (2122-2124, 2126-2128) inducing Notch intracellular domain (NICD) nuclear localization. The GFP-NICD (1963-2145) fusion protein deletion mutant without classical NLS was localized in the nucleus like the full length GFP-NICD. However, quadruple substitution mutant (T2122A T2124A S2126A T2128A) showed increased cytoplasmic localization. GSK-3{beta} enhanced nuclear localization and transcriptional activity of WT NICD but not of quadruple substitution mutant. In vitro kinase assays revealed that GSK-3{beta} phosphorylated S and T residues in NICD S/T-P-S/T domains. These results suggest that the novel S/T-P-S/T domain, phosphorylated by GSK-3{beta} is also involved in the nuclear localization of NICD as well as classical NLS.

Development of a dual-sinker densimeter for high-accuracy fluid P-V-T measurements

International Nuclear Information System (INIS)

McLinden, M.O.; Frederick, N.V.

1993-01-01

A dual-sinker densimeter to very accurately measure the pressure-volume-temperature (P-V-T) properties of fluids over a temperature range of 80 K to 520 K and at pressures up to 35 MPa is in the final stages of development at NIST. The density of a fluid is determined by measuring the difference in the buoyancy forces experienced by two sinkers of identical mass, surface area, and surface material, but very different volumes. The buoyancy forces on the sinkers are transmitted to a semi-microbalance by means of a magnetic suspension coupling. This paper reviews the principle of the measurement and describes the overall design of the system

Lavenergihuset tæt på målet!

DEFF Research Database (Denmark)

Rode, Carsten

2012-01-01

Lavenergihuset i Sisimiut blev indviet i april 2005. Det var projekteret til at have et årligt energiforbrug til opvarmning på 80 kWh/m2. Men gennem de første 4½ år af husets levetid har forbruget vist sig at ligge på ca. 140 kWh/m2 – altså ca. 75% mere end planlagt. I vinteren 2009/10 blev der dog...... isoleringsevnen er blevet bedre. Alt dette har gjort, at energiforbruget nu er nede på ca. 95 kWh/m2 målt fra december 2009 til november 2010. Indendørs har temperaturen været på ca. 23°C, mod de 21°C huset var planlagt til at have, og det teoretiske energiforbrug ved den højere indendørs temperatur skulle så...... muligt at redegøre for det sidste, der mangler i at husets ydeevne når målet. Umiddelbart betragtet har det givet en række udfordringer at følge huset og dets energiforbrug. Den tætte opfølgning har dog givet nogle unikke erfaringer, som de involverede og branchen kan tage ved lære af. I foredraget gives...

Identification of a High-Risk Group Among Patients With Oral Cavity Squamous Cell Carcinoma and pT1-2N0 Disease

Energy Technology Data Exchange (ETDEWEB)

Liao, Chun-Ta [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Lin, Chien-Yu [Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Radiation Oncology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University, Taoyuan, Taiwan (China); Fan, Kang-Hsing [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Radiation Oncology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University, Taoyuan, Taiwan (China); Wang, Hung-Ming [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Hema-Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Ng, Shu-Hang [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Lee, Li-Yu; Hsueh, Chuen [Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Chen, I-How; Huang, Shiang-Fu; Kang, Chung-Jan [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); and others

2012-01-01

Purpose: In the American Joint Committee on Cancer 2010 classification system, pT1-2N0 oral cavity squamous cell carcinoma (OSCC) is considered an early-stage cancer treatable with surgery alone (National Comprehensive Cancer Network 2010 guidelines). Our aim was to evaluate the feasibility of surgery alone for pT1-2N0 OSCC patients. Methods and Materials: Among 1279 previously untreated OSCC patients referred to our hospital between January 1996 and May 2008, we identified 457 consecutive patients with pT1-2N0 disease. All had radical tumor excision with neck dissection. A total of 387 patients showing pathologic margins greater than 4 mm and treated by surgery alone were included in the final analysis. All were followed up for at least 24 months after surgery or until death. The 5-year rates of control, distant metastasis, and survival were the main outcome measures. Results: The 5-year rates in the entire group of pT1-2N0 patients were as follows: local control, 91%; neck control, 92%; distant metastases, 1%; disease-free survival, 85%; disease-specific survival, 93%; and overall survival, 84%. Multivariate analysis identified poor differentiation and pathologic tumor depth of 4 mm or greater as independent risk factors for neck control, disease-free survival, and disease-specific survival. A scoring system using poor differentiation and tumor depth was formulated to define distinct prognostic groups. The presence of both poorly differentiated tumors and a tumor depth of 4 mm or greater resulted in significantly poorer 5-year neck control (p < 0.0001), disease-free (p < 0.0001), disease-specific (p < 0.0001), and overall survival (p = 0.0046) rates. Conclusion: The combination of poor differentiation and pathologic tumor depth of 4 mm or greater identified a subset of pT1-2N0 OSCC patients with poor outcome, who may have clinical benefit from postoperative adjuvant radiotherapy.

Measurement of the $t \\bar{t}$ Production Cross-Section in the Lepton Plus Jets Channel in $p \\bar{p}$ Collisions at $\\sqrt{s} =1.8$ TeV

Energy Technology Data Exchange (ETDEWEB)

Miao, Chyi Chang [Univ. of Michigan, Ann Arbor, MI (United States)

1997-01-01

This thesis summarizes the measurement of the t$\\bar{t}$ production cross section using 110 pb-1 of $\\bar{p}$p Collisions at √s = 1.8 TeV collected with the Collider Detector at Fermilab between August of 1992 and February of 1996.

Mali tõotab sõjalist tööpõldu aastateks / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2015-01-01

Malis on praegu käimas kolm rahvusvahelist sõjalist missiooni, mis kestavad tõenäoliselt veel aastaid. Terroriorganisatsioonid, mis tegutsesid enamasti riigi põhjaosas, külvavad hirmu ka lõunas

High fusion performance at high T i/T e in JET-ILW baseline plasmas with high NBI heating power and low gas puffing

Science.gov (United States)

Kim, Hyun-Tae; Sips, A. C. C.; Romanelli, M.; Challis, C. D.; Rimini, F.; Garzotti, L.; Lerche, E.; Buchanan, J.; Yuan, X.; Kaye, S.; contributors, JET

2018-03-01

This paper presents the transport analysis of high density baseline discharges in the 2016 experimental campaign of the Joint European Torus with the ITER-Like Wall (JET-ILW), where a significant increase in the deuterium-deuterium (D-D) fusion neutron rate (~2.8  ×  1016 s-1) was achieved with stable high neutral beam injection (NBI) powers of up to 28 MW and low gas puffing. Increase in T i exceeding T e were produced for the first time in baseline discharges despite the high electron density; this enabled a significant increase in the thermal fusion reaction rate. As a result, the new achieved record in fusion performance was much higher than the previous record in the same heating power baseline discharges, where T i  =  T e. In addition to the decreases in collisionality and the increases in ion heating fraction in the discharges with high NBI power, T i  >  T e can also be attributed to positive feedback between the high T i/T e ratio and stabilisation of the turbulent heat flux resulting from the ion temperature gradient driven mode. The high T i/T e ratio was correlated with high rotation frequency. Among the discharges with identical beam heating power, higher rotation frequencies were observed when particle fuelling was provided by low gas puffing and pellet injection. This reveals that particle fuelling played a key role for achieving high T i/T e, and the improved fusion performance.

Enterocin P Causes Potassium Ion Efflux from Enterococcus faecium T136 Cells

OpenAIRE

Herranz, Carmen; Cintas, Luis M.; Hernández, Pablo E.; Moll, Gert N.; Driessen, Arnold J. M.

2001-01-01

Enterocin P is a bacteriocin produced by Enterococcus faecium P13. We studied the mechanism of its bactericidal action using enterocin-P-sensitive E. faecium T136 cells. The bacteriocin is incapable of dissipating the transmembrane pH gradient. On the other hand, depending on the buffer used, enterocin P dissipates the transmembrane potential. Enterocin P efficiently elicits efflux of potassium ions, but not of intracellularly accumulated anions like phosphate and glutamate. Taken together, t...

USA tõstis tõkkepuu Vene WTO-püüdlustelt / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2006-01-01

USA ja Venemaa leppisid põhimõtteliselt kokku tingimustes, mille täitmise korral saab Venemaa WTO-ga liituda. Liitumise peavad heaks kiitma kõik WTO liikmesmaad, raskeks võib osutuda heakskiidu saamine Gruusialt

Search for the Higgs Boson Using High-pT Isolated Like-Sign Dil Events in 1.96-TeV Proton-Antiproton Collisions

Energy Technology Data Exchange (ETDEWEB)

Kobayashi, Hirokazu [Univ. of Tsukuba (Japan)

2005-03-01

Our physics objective is to search for the neutral on using events containing a like-sign dilepton pair in the following reaction: q$\\bar{q}$ → W^± H → W^± W*W* → ℓ^±ℓ^± + X. The relevant Higgs boson mass region is above 160 GeV/c² for the Standard Model Higgs boson where the branching fraction of H → W*W* supersedes that of H → b$\\bar{b}$. The search for this signature in the region at low mass (less than 135 GeV/c²) is, however, still important because we need to investigate various Higgs boson couplings as an essential test to convince that signals are attributed to the Higgs boson production. This channel also covers the case beyond the Standard Model that the Higgs boson couples only to the gauge bosons, which is referred to as the bosophilic or fermiophobic Higgs boson. The corresponding mass region suitable to our signature is above 110 GeV/c² where the branching fraction of H → γγ is overtaken by this channel. On the experimental side, the like-sign dilepton event is one of the cleanest signature in hadron collisions. This analysis exploiting such a distinctive signature is therefore expected to have a high potential of the sensitivity for the search of the Higgs boson. The data were collected with the CDF II detector between March 2002 and September 2003, corresponding to an integrated luminosity of 193.5 pb^-1. At off-line, the central region (|η| < 1.1) is considered for the lepton detection. We require at least one electron with E_T > 20 GeV or muon with p_T > 20 GeV/c which is considered to be responsible for firing the corresponding trigger, and at least one other electron with E{sub T} > 6 GeV or muon with p_T > 6 GeV/c. The leptons are required to be isolated in terms of the calorimeter cone-isolation with a cone size of R = 0.4. We require that the isolation is less than 2 GeV for each lepton. For the events with

MPID-T2: a database for sequence-structure-function analyses of pMHC and TR/pMHC structures.

Science.gov (United States)

Khan, Javed Mohammed; Cheruku, Harish Reddy; Tong, Joo Chuan; Ranganathan, Shoba

2011-04-15

Sequence-structure-function information is critical in understanding the mechanism of pMHC and TR/pMHC binding and recognition. A database for sequence-structure-function information on pMHC and TR/pMHC interactions, MHC-Peptide Interaction Database-TR version 2 (MPID-T2), is now available augmented with the latest PDB and IMGT/3Dstructure-DB data, advanced features and new parameters for the analysis of pMHC and TR/pMHC structures. http://biolinfo.org/mpid-t2. shoba.ranganathan@mq.edu.au Supplementary data are available at Bioinformatics online.

Graphene Oxide Based Nanocarrier Combined with a pH-Sensitive Tracer: A Vehicle for Concurrent pH Sensing and pH-Responsive Oligonucleotide Delivery.

Science.gov (United States)

Hsieh, Chia-Jung; Chen, Yu-Cheng; Hsieh, Pei-Ying; Liu, Shi-Rong; Wu, Shu-Pao; Hsieh, You-Zung; Hsu, Hsin-Yun

2015-06-03

We chemically tuned the oxidation status of graphene oxide (GO) and constructed a GO-based nanoplatform combined with a pH-sensitive fluorescence tracer that is designed for both pH sensing and pH-responsive drug delivery. A series of GOs oxidized to distinct degrees were examined to optimize the adsorption of the model drug, poly dT30. We determined that highly oxidized GO was a superior drug-carrier candidate in vitro when compared to GOs oxidized to lesser degrees. In the cell experiment, the synthesized pH-sensitive rhodamine dye was first applied to monitor cellular pH; under acidic conditions, protonated rhodamine fluoresces at 588 nm (λex=561 nm). When the dT30-GO nanocarrier was introduced into cells, a rhodamine-triggered competition reaction occurred, and this led to the release of the oligonucleotides and the quenching of rhodamine fluorescence by GO. Our results indicate high drug loading (FAM-dT30/GO=25/50 μg/mL) and rapid cellular uptake (<0.5 h) of the nanocarrier which can potentially be used for targeted RNAi delivery to the acidic milieu of tumors.

Unified model for small-t and high-t scattering at high energies: predictions at RHIC and LHC

Energy Technology Data Exchange (ETDEWEB)

Martynov, E. [National Academy of Sciences of Ukraine, N.N. Bogolyubov Institute for Theoretical Physics, Kiev (Ukraine); Nicolescu, B. [CNRS and Universite Pierre et Marie Curie, Theory Group, Laboratoire de Physique Nucleaire et des Hautes Energies (LPNHE), Paris (France)

2008-07-15

The urgency of predictions in the large-t region at LHC stimulated us to present a unified model of small- and high-t scattering at high energies. Our model is based on safe theoretical ground: analyticity, unitarity, Regge behavior, gluon exchange and saturation of bounds established in axiomatic quantum field theory. We make precise predictions for the behavior of the differential cross sections at high t, the evolution of the dip-shoulder structure localized in the region 0.5t vertical stroke t. (orig.)

Large-pT photoproduction of D*± mesons in ep collisions

International Nuclear Information System (INIS)

Kniehl, B.A.; Kramer, G.; Spira, M.

1996-10-01

The cross section for the inclusive photoproduction of large-p T D *± mesons is calculated at next-to-leading order, adopting different approaches to describe the fragmentation of charm quarks into D *± mesons. We treat the charm quark according to the massless factorization scheme, where it is assumed to be one of the active flavours inside the proton and the photon. We present inclusive single-particle distributions in transverse momentum and rapidity, including the contributions due to both direct and resolved photons. We compare and assess the various implementations of fragmentation. We argue that, in the high-p T regime, a particularly realistic description can be obtained by convoluting the Altarelli-Parisi-evolved fragmentation functions of Peterson et al. with the hard-scattering cross sections of massless partons where the factorization of the collinear singularities associated with final-state charm quarks is converted to the massive-charm scheme. The predictions thus obtained agree well with recent experimental data by the H1 and ZEUS Collaborations at DESY HERA, better than the all-massive calculation. (orig.)

Efecto de la raza y la edad sobre las concentraciones de hormonas tiroideas T3 y T4 de bovinos en condiciones tropicales Effect of the breed and age on the thyroid hormones T3 and T4 concentrations in bovines under tropical conditions

Directory of Open Access Journals (Sweden)

Rómulo Campos Gaona

2008-06-01

Full Text Available Para estudiar el efecto en condiciones de trópico seco de la edad y del grupo racial sobre las concentraciones séricas de las hormonas tiroideas T3 y T4, se muestrearon 158 animales de los grupos raciales Holstein, Lucerna, Hartón del Valle, Cebú Brahman y mestizo F1 (Cebú Brahman x Pardo Suizo, distribuidos en cuatro grupos de edad desde el nacimiento hasta el destete (8 meses. La concentración media de T3 fue 2.25 mmol/L y la de T4, 57.37 mmol/L. La correlación entre T3 y T4 fue de 0.53. Se encontró diferencia estadísticamente significativa para el efecto grupo racial, grupo de edad (PTo study the effect of age and breed on blood concentration of thyroid hormones T3 and T4 under the dry tropic conditions, 158 animals from the groups Holstein, Lucerna, Hartón del Valle, Brahman and crossbred F1 Brahman x Brown Swiss were sampled. The animals were allocated in four age groups from newborns calves until eight month old. The average T3 concentration was of 2.25 mmolL-¹ and the T4 was of 57.37 mmolL-¹. The correlation between T3 and T4 was of 0.53. A statistical significant difference (p<0.001 was found for the effects of age breed and group, but not difference was found for the interaction between breed and age (p=0.286. The breeds with higher blood concentrations of T3 and T4 were Holstein and Lucerna. The lowest concentration was found among the crossbred group. The higher concentration of T3 and T4 of thyroid hormones was found in the newborn group. As the calves grow, the concentrations of T3 and T4 decrease progressively. This study found that under dry tropic conditions, in a thermo-neutral borderline zone (according to the THI index the young bovines show clear differences in the concentration of the thyroid hormones

Fibroblast and T cells conditioned media induce maturation dendritic cell and promote T helper immune response

Directory of Open Access Journals (Sweden)

Masoumeh Asadi

2012-06-01

Full Text Available Dendritic cells (DCs induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium, PHA activated T cells (T cell conditioned medium, and mixture of fibroblast & PHA activated T cells (FCM-TCCM conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. Maturation factors included MCM and TNF-α as control group. FCM and TCCM, or FCM-TCCM supernatant were considered as the treatment group. Tumor antigens were added at day five. Matured DCs were harvested at day seven. Phenotypic and functional analyses were carried out using anti (CD14, CD80, CD86, CD83 and HLA-DR monoclonal antibodies. Phagocytic activity, mixed lymphocyte reaction (MLR and cytokine production were also evaluated. At the end of culturing period, significantly fully matured DCs with large amount cytoplasm and copious dendritic projections were found in the presence of MCM, TNF-α with or without FCM, TCCM, FCM as well as TCCM. Flow cytometric analysis revealed that expression of CD14 decreased in particular in treated DCs, at the 5th day and expression of CD80, CD86 and HLA-DR was higher when FCM, TCCM, FCM plus TCCM were added to maturation factor. This study demonstrated that DCs matured with these methods had optimum function in comparison with either factor alone.

Double longitudinal spin asymmetries in single hadron photoproduction at high p_T at COMPASS

CERN Document Server

Levillain, Maxime

This thesis presents a new study aiming at constraining the gluon contribution {\\Delta G} to the 1/2 nucleon spin. The collinear pQCD theoretical framework, on which it is based, deals with asymmetries calculated from cross-sections for single inclusive hadron in the regime of quasi-real photoproduction {Q^2 1 GeV/c). These calculations are done up to Next-to-Leading order with a foreseen inclusion of Next-to-Leading logarithm threshold gluon resummation, only performed for the unpolarised cross-sections yet. This makes the asymmetries sensitive to the gluon polarisation not only through Photon Gluon Fusion {\\gamma* g} but also through resolved {\\gamma*}g processes such as qg or gg. The measurement of the asymmetries is performed for all the COMPASS data available from 2002 to 2011 with a polarised muon beam at 160-200 GeV scattered off a longitudinally polarised target of deuteron ( {_6LiD} for 2002-2006) or proton ({NH_3} for 2007 and 2011). The asymmetries are presented in bins of pT and of pseudorapidity...

Evidence for the t-quark in p-barp collider data

International Nuclear Information System (INIS)

Barger, V.; Martin, A.D.; Phillips, R.J.N.

1983-02-01

A simple method is proposed to identify semileptonic weak decays t → eνb of any heavy particle t and to determine its mass independent of the t-production mechanism, using p-barp collider events that contain a single electron (or muon) and missing transverse momentum. Events with transverse mass Msub(T)(eν) > 3 GeV originate either from t-decays of mass msub(t) > Msub(T)(eν) + msub(b) or from W → eν decays; the latter is a distinctive background that can be subtracted. The Msub(T)(eν) distribution of electron events may be interpreted as being due to a t-quark with mass 25 to 40 GeV. (author)

Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling.

Science.gov (United States)

Song, Juhyun; Lee, Byeori; Kang, Somang; Oh, Yumi; Kim, Eosu; Kim, Chul-Hoon; Song, Ho-Taek; Lee, Jong Eun

2016-02-01

Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and the alteration of cellular homeostasis. Agmatine, which is biosynthesized by arginine decarboxylation, has been reported in previous in vitro to exert a protective effect against various stresses. In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Moreover, the senescence associated-β-galatosidase's activity in high glucose exposed neuronal cells was reduced by agmatine. Increased p21 and reduced p53 in high glucose conditioned cells were changed by agmatine. Ultimately, agmatine inhibits the neuronal cell senescence through the activation of p53 and the inhibition of p21. Here, we propose that agmatine may ameliorate neuronal cell senescence in hyperglycemia.

Patterns of Failure After Radical Cystectomy for pT3-4 Bladder Cancer: Implications for Adjuvant Radiation Therapy

Energy Technology Data Exchange (ETDEWEB)

Reddy, Abhinav V. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Pariser, Joseph J.; Pearce, Shane M. [Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Weichselbaum, Ralph R. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Smith, Norm D.; Steinberg, Gary D. [Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Liauw, Stanley L., E-mail: sliauw@radonc.uchicago.edu [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States)

2016-04-01

Purpose: In patients with muscle-invasive bladder cancer, local-regional failure (LF) has been reported to occur in up to 20% of patients following radical cystectomy. The goals of this study were to describe patterns of LF, as well as assess factors associated with LF in a cohort of patients with pT3-4 bladder cancer. This information may have implications towards the use of adjuvant radiation therapy. Methods and Materials: Patients with pathologic T3-4 N0-1 bladder cancer were examined from an institutional radical cystectomy database. Preoperative demographics and pathologic characteristics were examined. Outcomes included overall survival and LF. Local-regional failures were defined using follow-up imaging reports and scans, and the locations of LF were characterized. Variables were tested by univariate and multivariate analysis for association with LF and overall survival. Results: A total of 334 patients had pT3-4 and N0-1 disease after radical cystectomy and bilateral pelvic lymph node dissection. Of these, 46% received perioperative chemotherapy. The median age was 71 years old, and median follow-up was 11 months. On univariate analysis, margin status, pT stage, and pN stage, were all associated with LF (P<.05), however, on multivariate analysis, only pT and pN stages were significantly associated with LF (P<.05). Three strata of risk were defined, including low-risk patients with pT3N0 disease, intermediate-risk patients with pT3N1 or pT4N0 disease, and high-risk patients with pT4N1 disease, who had a 2-year incidence of LF of 12%, 33%, and 72%, respectively. The most common sites of pelvic relapse included the external and internal iliac lymph nodes (LNs) and obturator LN regions. Notably, 34% of patients with LF had local-regional only disease at the time of recurrence. Conclusions: Patients with pT4 or N1 disease have a 2-year risk of LF that exceeds 30%. These patients may be the most likely to benefit from local adjuvant therapies.

Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation

International Nuclear Information System (INIS)

Oh, Sera; Shin, Ji Hyun; Jang, Eun Jung; Won, Hee Yeon; Kim, Hyo Kyeong; Jeong, Mi- Gyeong; Kim, Kwang Soo; Hwang, Eun Sook

2016-01-01

Chloroquine (CQ) and amodiaquine (AQ) have been used for treating or preventing malaria for decades, and their application has expanded into treating inflammatory disease in humans. CQ and AQ are applicable for controlling rheumatoid arthritis, but their molecular mechanisms of anti-inflammatory activity remain to be elucidated. In this study, we examined the effects of CQ and AQ on T cell activation and T cell-mediated immune response. CQ had no significant effect on T cell numbers, but decreased the population of T cells with a high division rate. However, AQ treatment significantly increased the number of cells with low division rates and eliminated cells with high division rates, resulting in the inhibition of T cell proliferation triggered by T cell receptor stimulation, of which inhibition occurred in developing effector T helper and regulatory T cells, regardless of the different exogenous cytokines. Interestingly, the cyclin-dependent kinase inhibitor p21 was significantly and dose-dependently increased by CQ, and more potently by AQ, while other cell cycle regulators were unchanged. Both CQ and AQ elevated the transcription level of p21 though the activation of p53, but also blocked p21 protein degradation in the presence of cycloheximide, causing p21 protein accumulation mainly in the nucleus. Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-γ production in a dose dependent manner and potently inhibited the differentiation of IFN-γ-producing Th1 cells. These results demonstrate that CQ and AQ increase the expression level of p21 and inhibit T cell proliferation and the development of IFN-γ-producing Th1 cells, thereby revealing beneficial roles in treating a wide range of chronic inflammatory diseases mediated by inflammatory T cells. -- Highlights: •T cell division rates are suppressed by chloroquine and amodiaquine treatment. •Chloroquine and amodiaquine potently increased the p21 expression. •The p21 induction is

Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation

Energy Technology Data Exchange (ETDEWEB)

Oh, Sera; Shin, Ji Hyun; Jang, Eun Jung; Won, Hee Yeon; Kim, Hyo Kyeong; Jeong, Mi- Gyeong [College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750 (Korea, Republic of); Kim, Kwang Soo [Molecular Neurobiology Laboratory, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478 (United States); Hwang, Eun Sook, E-mail: eshwang@ewha.ac.kr [College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750 (Korea, Republic of)

2016-05-27

Chloroquine (CQ) and amodiaquine (AQ) have been used for treating or preventing malaria for decades, and their application has expanded into treating inflammatory disease in humans. CQ and AQ are applicable for controlling rheumatoid arthritis, but their molecular mechanisms of anti-inflammatory activity remain to be elucidated. In this study, we examined the effects of CQ and AQ on T cell activation and T cell-mediated immune response. CQ had no significant effect on T cell numbers, but decreased the population of T cells with a high division rate. However, AQ treatment significantly increased the number of cells with low division rates and eliminated cells with high division rates, resulting in the inhibition of T cell proliferation triggered by T cell receptor stimulation, of which inhibition occurred in developing effector T helper and regulatory T cells, regardless of the different exogenous cytokines. Interestingly, the cyclin-dependent kinase inhibitor p21 was significantly and dose-dependently increased by CQ, and more potently by AQ, while other cell cycle regulators were unchanged. Both CQ and AQ elevated the transcription level of p21 though the activation of p53, but also blocked p21 protein degradation in the presence of cycloheximide, causing p21 protein accumulation mainly in the nucleus. Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-γ production in a dose dependent manner and potently inhibited the differentiation of IFN-γ-producing Th1 cells. These results demonstrate that CQ and AQ increase the expression level of p21 and inhibit T cell proliferation and the development of IFN-γ-producing Th1 cells, thereby revealing beneficial roles in treating a wide range of chronic inflammatory diseases mediated by inflammatory T cells. -- Highlights: •T cell division rates are suppressed by chloroquine and amodiaquine treatment. •Chloroquine and amodiaquine potently increased the p21 expression. •The p21 induction is

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

Science.gov (United States)

Toulza, Frederic; Nosaka, Kisato; Takiguchi, Masafumi; Pagliuca, Tony; Mitsuya, Hiroaki; Tanaka, Yuetsu; Taylor, Graham P; Bangham, Charles R M

2009-11-15

Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL. We report here that the frequency of CD25(+) cells varied independently of the frequency of FoxP3(+) cells in both a cross-sectional study and in a longitudinal study of 2 patients with chronic ATLL. Furthermore, the capacity of ATLL cells to suppress proliferation of heterologous CD4(+)CD25(-) cells correlated with the frequency of CD4(+) FoxP3(+) cells but was independent of CD25 expression. Finally, the frequency of CD4(+)FoxP3(+) cells was inversely correlated with the lytic activity of HTLV-1-specific CTLs in patients with ATLL. We conclude that ATLL is not a tumor of FoxP3(+) regulatory T cells, and that a population of FoxP3(+) cells distinct from ATLL cells has regulatory functions and may impair the cell-mediated immune response to HTLV-1 in patients with ATLL.

p-barp elastic scattering at high energies

International Nuclear Information System (INIS)

Padua, A.B. de.

1986-01-01

The p-bar p elastic scattering is analysed in the energy range 9.78 pp werefitted under the hypothesis of a pure imaginary amplitude and writted as a sum of exponentials, that is, a(s,t) = a(s,O) Σ n i=l α i exp β i t. Using the parameters a(s,O), α i and β i we obtained the absorption constante K- pp , the form factor and the mean square radius of the - p matter distribution by the Chou-Yang model. These calculations reveal a dip around -t ≅ 1.3 (GeV/c) 2 at 31 and 62 GeV. (author) [pt

MvaT Family Proteins Encoded on IncP-7 Plasmid pCAR1 and the Host Chromosome Regulate the Host Transcriptome Cooperatively but Differently.

Science.gov (United States)

Yun, Choong-Soo; Takahashi, Yurika; Shintani, Masaki; Takeda, Toshiharu; Suzuki-Minakuchi, Chiho; Okada, Kazunori; Yamane, Hisakazu; Nojiri, Hideaki

2016-02-01

MvaT proteins are members of the H-NS family of proteins in pseudomonads. The IncP-7 conjugative plasmid pCAR1 carries an mvaT-homologous gene, pmr. In Pseudomonas putida KT2440 bearing pCAR1, pmr and the chromosomally carried homologous genes, turA and turB, are transcribed at high levels, and Pmr interacts with TurA and TurB in vitro. In the present study, we clarified how the three MvaT proteins regulate the transcriptome of P. putida KT2440(pCAR1). Analyses performed by a modified chromatin immunoprecipitation assay with microarray technology (ChIP-chip) suggested that the binding regions of Pmr, TurA, and TurB in the P. putida KT2440(pCAR1) genome are almost identical; nevertheless, transcriptomic analyses using mutants with deletions of the genes encoding the MvaT proteins during the log and early stationary growth phases clearly suggested that their regulons were different. Indeed, significant regulon dissimilarity was found between Pmr and the other two proteins. Transcription of a larger number of genes was affected by Pmr deletion during early stationary phase than during log phase, suggesting that Pmr ameliorates the effects of pCAR1 on host fitness more effectively during the early stationary phase. Alternatively, the similarity of the TurA and TurB regulons implied that they might play complementary roles as global transcriptional regulators in response to plasmid carriage. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Measurement of the nuclear modification factor for high-$p_\\mathrm{T}$ charged hadrons in p+Pb collisions with the ATLAS detector

CERN Document Server

Balek, Petr; The ATLAS collaboration

2016-01-01

The charged hadron spectra in p+Pb and pp collisions at $\\sqrt{s}=5.02$TeV are measured with the ATLAS experiment at the LHC. The measurements are performed with p+Pb data recorded in 2013 with an integrated luminosity of 25nb${}^{-1}$ and pp data recorded in 2015 with an integrated luminosity of 28pb${}^{-1}$. The p+Pb results are directly compared to pp spectra, as a ratio scaled by the number of binary nucleon-nucleon collisions, the nuclear modification factor $R_\\mathrm{pPb}$. The study of $R_\\mathrm{pPb}$ allows a detailed comparison of the collision systems in different centrality intervals and up to high transverse momentum. It is shown that the nuclear modification factor does not have any significant deviation from unity in the high transverse momentum region.

On the nuclear shell effects appeared in (p,t) analyzing power calculations

International Nuclear Information System (INIS)

Kubo, Ken-ichi

1980-01-01

Origin of shell effects found in two-step (p, d, t) calculation, which play an important role for understanding the observed 'anomalous' (p, t) analyzing powers, is clarified based on the selections for transferred angular momenta. (author)

Study of High Energy Nucleus-Nucleus Interactions Using the $\\Omega^{'}$ Spectrometer Equipped with a Multiparticle High $p_{T}$ Detector

CERN Multimedia

2002-01-01

The experiment is looking for new physics in 200~GeV/c per nucleon sulphur-tungsten collisions in the $\\Omega$' spectrometer. In particular, we are looking for a quark gluon plasma signature in the increase of the production rate of strange and multistrange baryons and antibaryons. In view of the large number of secondaries, we are using a special detector arrangement, called a ``butterfly system'', which has a large acceptance for particles with 2.2~$\\leq$~ $y _{l}ab $ ~$\\leq$~3.2 and $p _{T} $ ~$>$~0.6 ~GeV/c and is insensitive to all the other particles.

General P-T fit construction for He, N2, Ar, H2 and Ne VPT used at Fermilab

International Nuclear Information System (INIS)

Geynisman, M.; Makara, J.

1992-01-01

Polynomial fits are constructed for Fermilab Tevatron vapor pressure thermometers (VPT) for use with ACNET database. Fit coefficients and P-T graphs are included. Fits cover the VPT saturation region and the gas region. The thermodynamic analysis of VPT bulb is used to define transition points for each cryogenic VPT with given geometry and ''charge'' conditions. The methodology is described to repeat fit construction calculations for any geometry and ''charge'' conditions if required

Semantic conditioning of salivary pH for communication.

Science.gov (United States)

Ruf, Carolin A; De Massari, Daniele; Wagner-Podmaniczky, Franziska; Matuz, Tamara; Birbaumer, Niels

2013-10-01

Semantic conditioning of salivary pH was investigated as a new paradigm for binary communication. In a sample of eleven healthy participants, affirmation or negation of presented statements were paired with milk and lemon to condition changes in salivary pH level. Significant differences between the conditioned reactions were found at the group level. However, the analysis of pH changes on single-subject level revealed significant differences between affirmative and negative responses to the presented statements only for isolated samples in few participants. When classifying a change in pH value of more than .01 as correct response to a statement, only responses to affirmative statements reached mean accuracies of more than 60%. Improvements in the paradigm are necessary before testing it with the critical target population of patients to prove its profit for basic yes/no communication in case no other reliable means of communication could be preserved. Copyright © 2013 Elsevier B.V. All rights reserved.

Jet p{sub T} resummation in Higgs production at NNLL'+NNLO

Energy Technology Data Exchange (ETDEWEB)

Stewart, Iain W. [Massachusetts Institute of Technology, Cambridge, MA (United States). Center for Theoretical Physics; Tackmann, Frank J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Gruppe Theorie; Walsh, Jonathan R.; Zuberi, Saba [California Univ., Berkeley, CA (United States). Ernes Orlando Lawrence Berkeley National Laboratory

2013-07-15

We present predictions for Higgs production via gluon fusion with a p{sub T} veto on jets and with the resummation of jet-veto logarithms at NNLL'+NNLO order. These results incorporate explicit O({alpha}{sub s}{sup 2}) calculations of soft and beam functions, which include the dominant dependence on the jet radius R. In particular the NNLL' order accounts for the correct boundary conditions for the N{sup 3}LL resummation, for which the only unknown ingredients are higher-order anomalous dimensions. We use scale variations in a factorization theorem in both rapidity and virtuality space to estimate the perturbative uncertainties, accounting for both higher fixed-order corrections as well as higher-order towers of jet-p{sub T} logarithms. This formalism also predicts the correlations in the theory uncertainty between the exclusive 0-jet and inclusive 1-jet bins. At the values of R used experimentally, there are important corrections due to jet algorithm clustering that include logarithms of R. Although we do not sum logarithms of R, we do include an explicit contribution in our uncertainty estimate to account for higher-order jet clustering logarithms. Precision predictions for this H+0-jet cross section and its theoretical uncertainty are an integral part of Higgs analyses that employ jet binning.

Adverse health effects of high-effort/low-reward conditions.

Science.gov (United States)

Siegrist, J

1996-01-01

In addition to the person-environment fit model (J. R. French, R. D. Caplan, & R. V. Harrison, 1982) and the demand-control model (R. A. Karasek & T. Theorell, 1990), a third theoretical concept is proposed to assess adverse health effects of stressful experience at work: the effort-reward imbalance model. The focus of this model is on reciprocity of exchange in occupational life where high-cost/low-gain conditions are considered particularly stressful. Variables measuring low reward in terms of low status control (e.g., lack of promotion prospects, job insecurity) in association with high extrinsic (e.g., work pressure) or intrinsic (personal coping pattern, e.g., high need for control) effort independently predict new cardiovascular events in a prospective study on blue-collar men. Furthermore, these variables partly explain prevalence of cardiovascular risk factors (hypertension, atherogenic lipids) in 2 independent studies. Studying adverse health effects of high-effort/low-reward conditions seems well justified, especially in view of recent developments of the labor market.

Dipole pomeron and. pi. /sup -/p elastic scattering at high energies

Energy Technology Data Exchange (ETDEWEB)

Fazal-E-Aleem (Panjab Univ., Lahore (Pakistan). Physics Dept.)

1982-10-16

The differential cross-sections for high-energy ..pi../sup -/p elastic scattering showing structure near -t=4 (GeV/c)/sup 2/ for psub(L)=50 and 200 GeV/c together with total cross-sections for 50<=psub(L)<=370 GeV/c, and with -t extending up to 11 (GeV/c)/sup 2/ have been fitted by using a dipole pomeron model.

Effects of 60 MeV C5+ ion irradiation on PmT-PVC and p-TSA doped PoT-PVC blends

International Nuclear Information System (INIS)

Lakshmi, G.B.V.S.; Siddiqui, Azher M.; Ali, Vazid; Kulriya, Pawan K.; Zulfequar, M.

2008-01-01

Poly(m-toluidine) (PmT) and Poly(o-toluidine) (PoT) have been synthesized from derivatives of aniline (m-toluidine), (o-toluidine) monomers by chemical oxidative polymerization method. After polymerization, PoT powder was doped with p-toluene sulphonic acid (p-TSA) and the polymer powders were blended with poly vinyl chloride (PVC) to achieve PmT and p-TSA doped PoT dispersed films. XRD, FTIR and UV-visible studies were carried out to get their structural changes and optical information. These blends were irradiated by 60 MeV C 5+ ions with different fluences. Post Irradiation XRD, FTIR and UV-visible spectroscopy were also performed on all films. On p-TSA doped PoT-PVC blends dc-conductivity measurements are also carried out before and after irradiation. The results show structural modifications which lead to changes in optical and electrical properties

Effects of High-Definition and Conventional tDCS on Response Inhibition.

Science.gov (United States)

Hogeveen, J; Grafman, J; Aboseria, M; David, A; Bikson, M; Hauner, K K

2016-01-01

Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task. Copyright © 2016 Elsevier Inc. All rights reserved.

Solubilities of iron and nickel oxides under high temperature and high pressure conditions

International Nuclear Information System (INIS)

Choi, Ke-Chon; Jung, Yong-Ju; Yeon, Jei-Won; Jee, Kwang-Yong

2007-01-01

The purposes of primary coolant chemistry are to assure fuel and material integrity and to minimize out of core radiation fields. During the PWR operation, crud deposits are expected on the cladding, leading to cladding failure and raising the radioactivity. Such deposits come from the corrosion products of system surface. To achieve optimal conditions for primary coolant, basic researches on mass transfer, deposition and solubility of corrosion products are needed. The initial stage of crud formation could be the studies on the solubility of a structural material. It has been known that the solubility of metal oxides in boric acid under high temperature and high pressure condition depends on the pH and dissolved hydrogen. Thus, the effect of various pH on the solubility of metal oxide in boric acid solution was investigated in this work

Diagnostic Accuracy of a Combined Analysis of Cerebrospinal Fluid t-PrP, t-tau, p-tau, and Aβ42 in the Differential Diagnosis of Creutzfeldt-Jakob Disease from Alzheimer's Disease with Emphasis on Atypical Disease Variants.

Science.gov (United States)

Abu Rumeileh, Samir; Lattanzio, Francesca; Stanzani Maserati, Michelangelo; Rizzi, Romana; Capellari, Sabina; Parchi, Piero

2017-01-01

According to recent studies, the determination of cerebrospinal fluid (CSF) total tau (t-tau)/phosphorylated tau (p-tau) ratio and total prion protein (t-PrP) levels significantly improves the accuracy of the diagnosis of Alzheimer's disease (AD) in atypical cases with clinical or laboratory features mimicking Creutzfeldt-Jakob disease (CJD). However, this has neither been validated nor tested in series including atypical CJD variants. Furthermore, the added diagnostic value of amyloid-β (Aβ)42 remains unclear. To address these issues, we measured t-PrP, 14-3-3, t-tau, p-tau, and Aβ42 CSF levels in 45 typical and 44 atypical/rapidly progressive AD patients, 54 typical and 54 atypical CJD patients, and 33 controls. CJD patients showed significantly lower CSF t-PrP levels than controls and AD patients. Furthermore, atypical CJD was associated with lower t-PrP levels in comparison to typical CJD. T-tau, 14-3-3, or t-PrP alone yielded, respectively, 80.6, 63.0, and 73.0% sensitivity and 75.3, 92.1, and 75% specificity in distinguishing AD from CJD. On receiver operating characteristic (ROC) curve analyses of biomarker combinations, the (t-tau×Aβ42)/(p-tau×t-PrP) ratio achieved the best accuracy, with 98.1% sensitivity and 97.7% specificity overall, and 96.2% sensitivity and 95.5% specificity for the "atypical" disease groups. Our results show that the combined analysis of CSF t-PrP, t-tau, p-tau, and Aβ42 is clinically useful in the differential diagnosis between CJD and AD. Furthermore, the finding of reduced CSF t-PrP levels in CJD patients suggest that, likewise Aβ42 in AD, CSF t-PrP levels reflect the extent of PrPc conversion into abnormal PrP (PrPSc) and the burden of PrPSc deposition in CJD.

Synthesis and X-ray structures of dilithium complexes of the phosphonate anions [PhP(E)(N(t)Bu)(2)](2-) (E = O, S, Se, Te) and dimethylaluminum derivatives of [PhP(E)(N(t)Bu)(NH(t)Bu)](-) (E = S, Se).

Science.gov (United States)

Briand, Glen G; Chivers, Tristram; Krahn, Mark; Parvez, Masood

2002-12-16

The dilithium salts of the phosphonate dianions [PhP(E)(N(t)Bu)(2)](2-) (E = O, S, Se) are generated by the lithiation of [PhP(E)(NH(t)Bu)(2)] with n-butyllithium. The formation of the corresponding telluride (E = Te) is achieved by oxidation of [Li(2)[PhP(N(t)Bu)(2)

Kunsti tõmbavad vaatama p-tähed : uus näitus lastekunstikooli galeriis / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2008-01-01

Näitus "P... ja p... kunst" Tartu Lastekunstikooli galeriis, kuraator Margus Kiis. Oma töid eksponeerivad Rauno Thomas Moss, Enn Tegova, Maris Palgi, Jane Remm, Kristiina Viin, Martin Vaher, Kaspar Jassa, Mariliin Kindsiko jt.

Long-term strength and allowable stresses of grade 10Kh9MFB and X10CrMoVNb9-1 (T91/P91) chromium heat-resistant steels

Science.gov (United States)

Skorobogatykh, V. N.; Danyushevskiy, I. A.; Schenkova, I. A.; Prudnikov, D. A.

2015-04-01

Currently, grade X10CrMoVNb9-1 (T91, P91) and 10Kh9MFB (10Kh9MFB-Sh) chromium steels are widely applied in equipment manufacturing for thermal power plants in Russia and abroad. Compilation and comparison of tensile, impact, and long-term strength tests results accumulated for many years of investigations of foreign grade X10CrMoVNb9-1, T91, P91, and domestic grade 10Kh9MFB (10Kh9MFB-Sh) steels is carried out. The property identity of metals investigated is established. High strength and plastic properties of steels, from which pipes and other products are made, for operation under creep conditions are confirmed. Design characteristics of long-term strength on the basis of tests with more than one million of hour-samples are determined ( and at temperatures of 500-650°C). The table of recommended allowable stresses for grade 10Kh9MFB, 10Kh9MFB-SH, X10CrMoVNb9-1, T91, and P91 steels is developed. The long-time properties of pipe welded joints of grade 10Kh9MFB+10Kh9MFB, 10Kh9MFB-Sh+10Kh9MFB-Sh, X10CrMoVNb9-1+X10CrMoVNb9-1, P91+P91, T91+T91, 10Kh9MFB (10Kh9MFB-Sh)+X10CrMoVNb9-1(T/P91) steels is researched. The welded joint reduction factor is experimentally determined.

FoxP3 mRNA splice forms in synovial CD4+ T cells in rheumatoid arthritis and psoriatic arthritis

DEFF Research Database (Denmark)

Ryder, L Rebekka; Bartels, Else Marie; Woetmann, Anders

2012-01-01

Our aim was to elucidate the relative amount of the different splice forms of FoxP3 mRNA in CD4+ T cells in peripheral blood (PB) compared to synovial fluid (SF) in RA and PsA patients. FoxP3 mRNA was measured using a quantitative real-time PCR method. CD4+ T cells were isolated from 17 paired...... samples of PB and SF from RA and PsA patients, and PB from 10 controls. FoxP3fl and FoxP3Δ2 mRNA was significantly increased (6.7 and 2.1-fold, respectively) in PB CD4+ T cells from RA patients compared to controls. FoxP3fl and Δ2 mRNA in SF CD4+ T cells was increased compared to controls in sero......-negative RA and PsA, but not in sero-positive RA patients, who had a high FoxP3 expression in both PB and SF. The FoxP3Δ2Δ7 mRNA was barely detectable in patient samples, and not at all in healthy individuals. We provide evidence of an increased expression of FoxP3 splice forms in synovial CD4+ T cells from...

Palindromic nucleotide analysis in human T cell receptor rearrangements.

Directory of Open Access Journals (Sweden)

Santosh K Srivastava

Full Text Available Diversity of T cell receptor (TCR genes is primarily generated by nucleotide insertions upon rearrangement from their germ line-encoded V, D and J segments. Nucleotide insertions at V-D and D-J junctions are random, but some small subsets of these insertions are exceptional, in that one to three base pairs inversely repeat the sequence of the germline DNA. These short complementary palindromic sequences are called P nucleotides. We apply the ImmunoSeq deep-sequencing assay to the third complementarity determining region (CDR3 of the β chain of T cell receptors, and use the resulting data to study P nucleotides in the repertoire of naïve and memory CD8(+ and CD4(+ T cells. We estimate P nucleotide distributions in a cross section of healthy adults and different T cell subtypes. We show that P nucleotide frequency in all T cell subtypes ranges from 1% to 2%, and that the distribution is highly biased with respect to the coding end of the gene segment. Classification of observed palindromic sequences into P nucleotides using a maximum conditional probability model shows that single base P nucleotides are very rare in VDJ recombination; P nucleotides are primarily two bases long. To explore the role of P nucleotides in thymic selection, we compare P nucleotides in productive and non-productive sequences of CD8(+ naïve T cells. The naïve CD8(+ T cell clones with P nucleotides are more highly expanded.

Prospects of a search for $t\\bar{t}$ resonances at the High Luminosity LHC with an upgraded ATLAS Detector

CERN Document Server

Duncan, Anna Kathryn; The ATLAS collaboration

2017-01-01

A study of the expected mass reach of a search for new high-mass resonances decaying to a top quark pair using a simulation of the upgraded ATLAS experiment and using an integrated luminosity of 3000 fb$^{-1}$ from the High Luminosity LHC has been made. The simulation of the upgraded ATLAS experiment under HL-LHC conditions, including pileup, was done using parameterised estimates of the performance. Expected upper limits are set on the cross section of a $t\\bar{t}$ resonance in a benchmark model for several signal masses and show that particles with masses up to 4 TeV can be seen.

Identification of a High-Risk Group Among Patients With Oral Cavity Squamous Cell Carcinoma and pT1–2N0 Disease

International Nuclear Information System (INIS)

Liao, Chun-Ta; Lin, Chien-Yu; Fan, Kang-Hsing; Wang, Hung-Ming; Ng, Shu-Hang; Lee, Li-Yu; Hsueh, Chuen; Chen, I-How; Huang, Shiang-Fu; Kang, Chung-Jan

2012-01-01

Purpose: In the American Joint Committee on Cancer 2010 classification system, pT1–2N0 oral cavity squamous cell carcinoma (OSCC) is considered an early-stage cancer treatable with surgery alone (National Comprehensive Cancer Network 2010 guidelines). Our aim was to evaluate the feasibility of surgery alone for pT1–2N0 OSCC patients. Methods and Materials: Among 1279 previously untreated OSCC patients referred to our hospital between January 1996 and May 2008, we identified 457 consecutive patients with pT1–2N0 disease. All had radical tumor excision with neck dissection. A total of 387 patients showing pathologic margins greater than 4 mm and treated by surgery alone were included in the final analysis. All were followed up for at least 24 months after surgery or until death. The 5-year rates of control, distant metastasis, and survival were the main outcome measures. Results: The 5-year rates in the entire group of pT1–2N0 patients were as follows: local control, 91%; neck control, 92%; distant metastases, 1%; disease-free survival, 85%; disease-specific survival, 93%; and overall survival, 84%. Multivariate analysis identified poor differentiation and pathologic tumor depth of 4 mm or greater as independent risk factors for neck control, disease-free survival, and disease-specific survival. A scoring system using poor differentiation and tumor depth was formulated to define distinct prognostic groups. The presence of both poorly differentiated tumors and a tumor depth of 4 mm or greater resulted in significantly poorer 5-year neck control (p < 0.0001), disease-free (p < 0.0001), disease-specific (p < 0.0001), and overall survival (p = 0.0046) rates. Conclusion: The combination of poor differentiation and pathologic tumor depth of 4 mm or greater identified a subset of pT1–2N0 OSCC patients with poor outcome, who may have clinical benefit from postoperative adjuvant radiotherapy.

A measurement of inclusive π0 production at large psub(T) from p-p collisions at the CERN ISR

International Nuclear Information System (INIS)

Angelis, A.L.S.; Lyons, L.; Phinney, N.; Segar, A.M.; Wallace-Hadrill, J.; White, T.O.; Yelton, J.M.; Blumenfeld, B.J.; Hollebeek, R.J.; Lederman, L.M.; Levinthal, D.; Vidal, R.A.; Camilleri, L.; Papa, C. del; Di Lella, L.; Pope, B.G.; Pordes, S.H.; Singh-Sidhu, J.; Smith, A.M.; Chapin, T.J.; Cool, R.L.; Dimcovski, Z.; Linnemann, J.T.; Rothenberg, A.F.; Tannenbaum, M.J.

1978-01-01

The inclusive cross section for large psub(T) π 0 production near 90 0 in p-p collisions at the CERN ISR is presented for centre-of-mass energies 30.7, 53.1 and 62.4 GeV. The data are inconsistent with scaling of the form psup(-n)sub(T)F(xsub(T)), with constant n or with n allowed to depend on xsub(T)=2psub(T)/√s. For √s=53.1 and 62.4 GeV, the value of n found for 3.5< psub(T)<7.0 GeV/c is n=8.0+-0.5, in agreement with previous experiments. However, for 7.5< psub(T)<14.0 GeV/c the value becomes n=5.1+-0.4. (Auth.)

Enterocin P Selectively Dissipates the Membrane Potential of Enterococcus faecium T136

Science.gov (United States)

Herranz, C.; Chen, Y.; Chung, H.-J.; Cintas, L. M.; Hernández, P. E.; Montville, T. J.; Chikindas, M. L.

2001-01-01

Enterocin P is a pediocin-like, broad-spectrum bacteriocin which displays a strong inhibitory activity against Listeria monocytogenes. The bacteriocin was purified from the culture supernatant of Enterococcus faecium P13, and its molecular mechanism of action against the sensitive strain E. faecium T136 was evaluated. Although enterocin P caused significant reduction of the membrane potential (ΔΨ) and the intracellular ATP pool of the indicator organism, the pH gradient (ΔpH) component of the proton motive force (Δp) was not dissipated. By contrast, enterocin P caused carboxyfluorescein efflux from E. faecium T136-derived liposomes. PMID:11282622

Light-quarks Yukawa couplings and new physics in exclusive high-pT Higgs boson +jet and Higgs boson + b -jet events

Science.gov (United States)

Cohen, Jonathan; Bar-Shalom, Shaouly; Eilam, Gad; Soni, Amarjit

2018-03-01

We suggest that the exclusive Higgs +light (or b)-jet production at the LHC, p p →h +j (jb), is a rather sensitive probe of the light-quarks Yukawa couplings and of other forms of new physics (NP) in the Higgs-gluon h g g and quark-gluon q q g interactions. We study the Higgs pT-distribution in p p →h +j (jb)→γ γ +j (jb), i.e., in h +j (jb) production followed by the Higgs decay h →γ γ , employing the (pT-dependent) signal strength formalism to probe various types of NP which are relevant to these processes and which we parametrize either as scaled Standard Model (SM) couplings (the kappa-framework) and/or through new higher dimensional effective operators (the SMEFT framework). We find that the exclusive h +j (jb) production at the 13 TeV LHC is sensitive to various NP scenarios, with typical scales ranging from a few TeV to O (10 ) TeV , depending on the flavor, chirality and Lorentz structure of the underlying physics.

Microbial C:P stoichiometry is shaped by redox conditions along an elevation gradient in humid tropical rainforests

Science.gov (United States)

Lin, Y.; Gross, A.; Silver, W. L.

2017-12-01

Elemental stoichiometry of microorganisms is intimately related to ecosystem carbon and nutrient fluxes and is ultimately controlled by the chemical (plant tissue, soil, redox) and physical (temperature, moisture, aeration) environment. Previous meta-analyses have shown that the C:P ratio of soil microbial biomass exhibits significant variations among and within biomes. Little is known about the underlying causes of this variability. We examined soil microbial C:P ratios along an elevation gradient in the Luquillo Experimental Forest in Puerto Rico. We analyzed soils from mixed forest paired with monodominant palm forest every 100 m from 300 m to 1000 m a.s.l.. Mean annual precipitation increased with increasing elevation, resulting in stronger reducing conditions and accumulation of soil Fe(II) at higher elevations. The mean value and variability of soil microbial C:P ratios generally increased with increasing elevation except at 1000 m. At high elevations (600-900 m), the average value of microbial C:P ratio (108±10:1) was significantly higher than the global average ( 55:1). We also found that soil organic P increased with increasing elevation, suggesting that an inhibition of organic P mineralization, not decreased soil P availability, may cause the high microbial C:P ratio. The soil microbial C:P ratio was positively correlated with soil HCl-extractable Fe(II), suggesting that reducing conditions may be responsible for the elevational changes observed. In a follow-up experiment, soils from mixed forests at four elevation levels (300, 500, 700, and 1000 m) were incubated under aerobic and anaerobic conditions for two weeks. We found that anaerobic incubation consistently increased the soil microbial C:P ratio relative to the aerobic incubation. Overall, our results indicate that redox conditions can shift the elemental composition of microbial biomass. The high microbial C:P ratios induced under anoxic conditions may reflect inhibition of microbial P

Interim Evaluation of the Project P.A.T.H.S.: Findings Based on Different Datasets

Directory of Open Access Journals (Sweden)

Daniel T. L. Shek

2012-01-01

Full Text Available Interim evaluation studies were carried out in order to examine the implementation details of the Tier 1 Program of the Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes in Hong Kong. Quantitative results of the interim evaluation findings based on eight datasets collected from 2006 to 2009 are reported in this paper. Three hundred and seventy-eight schools were randomly selected to provide information on the implementation details of the program via face-to-face interviews, telephone interviews, and self-completed questionnaires. Results showed that a majority of the workers perceived that the students had positive responses to the program and the program was helpful to the students. In conjunction with other process evaluation findings, the present study suggests that the implementation quality of the Tier 1 Program of the Project P.A.T.H.S. is high. The present study also provides support for the effectiveness of the Tier 1 Program of the Project P.A.T.H.S. in Hong Kong.

Investigation of two-phase flow instability under SMART-P core conditions

International Nuclear Information System (INIS)

Hwang, Dae Hyun; Lee, Chung Chan

2005-01-01

An integral-type advanced light water reactor, named SMART-P, is being continuously studied at KAERI. The reactor core consists of hundreds of closed-channel type fuel assemblies with vertical upward flows. The upper and lower parts of the fuel assembly channels are connected to the common heads. The constant pressure drop imposed on the channel is responsible for the occurrence of density wave oscillations under local boiling and/or natural circulation conditions. The fuel assembly channel with oscillatory flow is highly susceptible to experience the CHF which may cause the fuel failure due to a sudden increase of the cladding temperature. Thus, prevention of the flow instability is an important criterion for the SMART-P core design. Experimental and analytical studies have been conducted in order to investigate the onset of flow instability (OFI) under SMART core conditions. The parallel channel oscillations were observed in a high pressure water-loop test facility. A linear stability analysis model in the frequency-domain was developed for the prediction of the marginal stability boundary (MSB) in the parallel boiling channels

Measurement of the cross section for t anti-t production in p anti-p collisions using the kinematics of lepton + jets events

Energy Technology Data Exchange (ETDEWEB)

Acosta, D.; Adelman, J.; Affolder, Anthony A.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; Annovi, A.; Antos, J.; Aoki,; Apollinari, G.; Arisawa, T.; Arguin, J.-F.; Artikov, A.; Ashmanskas, W.; Attal, A.; Azfar, F.; Azzi-Bacchetta, P.; /Taiwan, Inst. Phys. /Argonne /Barcelona, IFAE /INFN,

2005-04-01

The authors present a measurement of the top pair production cross section in p{bar p} collisions at {radical}s = 1.96 TeV. We collect a data sample with an integrated luminosity of 194 {+-} 11 pb{sup -1} with the CDF II detector at the Fermilab Tevatron. We use an artificial neural network technique to discriminate between top pair production and background processes in a sample of 519 lepton + jets events, which have one isolated energetic charged lepton, large missing transverse energy and at least three energetic jets. We measure the top pair production cross section to be {sigma}{sub t{bar t}} = 6.6 {+-} 1.1 {+-} 1.5 pb, where the first uncertainty is statistical and the second is systematic.

The T2-Shortening Effect of Gadolinium and the Optimal Conditions for Maximizing the CNR for Evaluating the Biliary System: a Phantom Study

International Nuclear Information System (INIS)

Lee, Mi Jung; Kim, Myung Joon; Yoon, Choon Sik; Song, Si Young; Park, Kyung Soo; Kim, Woo Sun

2011-01-01

Clear depiction of the common bile duct is important when evaluating neonatal cholestasis in order to differentiate biliary atresia from other diseases. During MR cholangiopancreatography, the T2-shortening effect of gadolinium can increase the contrast-to-noise ratio (CNR) of the bile duct and enhance its depiction. The purpose of this study was to confirm, by performing a phantom study, the T2-shortening effect of gadolinium, to evaluate the effect of different gadolinium chelates with different gadolinium concentrations and different magnetic field strengths for investigating the optimal combination of these conditions, and for identifying the maximum CNR for the evaluation of the biliary system. MR imaging using a T2-weighted single-shot fast spin echo sequence and T2 relaxometry was performed with a sponge phantom in a syringe tube. Two kinds of contrast agents (Gd-DTPA and Gd-EOB-DTPA) with different gadolinium concentrations were evaluated with 1.5T and 3T scanners. The signal intensities, the CNRs and the T2 relaxation time were analyzed. The signal intensities significantly decreased as the gadolinium concentrations increased (p < 0.001) with both contrast agents. These signal intensities were higher on a 3T (p < 0.001) scanner. The CNRs were higher on a 1.5T (p < 0.001) scanner and they showed no significant change with different gadolinium concentrations. The T2 relaxation time also showed a negative correlation with the gadolinium concentrations (p < 0.001) and the CNRs showed decrease more with Gd-EOB-DTPA (versus Gd-DTPA; p < 0.001) on a 3T scanner (versus 1.5T; p < 0.001). A T2-shortening effect of gadolinium exhibits a negative correlation with the gadolinium concentration for both the signal intensities and the T2 relaxation time. A higher CNR can be obtained with Gd-DTPA on a 1.5T MRI scanner.

P, C and T: Different Properties on the Kinematical Level

Science.gov (United States)

Dvoeglazov, Valeriy V.

2018-04-01

We study the discrete symmetries (P,C and T) on the kinematical level within the extended Poincaré Group. On the basis of the Silagadze research, we investigate the question of the definitions of the discrete symmetry operators both on the classical level, and in the secondary-quantization scheme. We study the physical contents within several bases: light-front formulation, helicity basis, angular momentum basis, and so on, on several practical examples. We analize problems in construction of the neutral particles in the the (1/2, 0) + (0, 1/2) representation, the (1, 0) + (0, 1) and the (1/2, 1/2) representations of the Lorentz Group. As well known, the photon has the quantum numbers 1‑, so the (1, 0) + (0, 1) representation of the Lorentz group is relevant to its description. We have ambiguities in the definitions of the corresponding operators P, C; T, which lead to different physical consequences. It appears that the answers are connected with the helicity basis properties, and commutations/anticommutations of the corresponding operators, P, C, T, and C 2, P 2, (CP)2 properties. This contribution is the review paper of my previous work [2, 3].

Measurements of T20 in backward elastic d p scattering at deuteron momenta 3.5 - 6 GeV/c

International Nuclear Information System (INIS)

Azhgirej, L.S.; Borzunov, Yu.T.; Chernykh, E.V.

1994-01-01

We present results of measurements of the tensor analyzing power T 20 in d p backward elastic scattering at initial deuterons momenta 3.5-6.0 GeV/c, which corresponds to the range of internal momentum of the deuteron constituents k = 0.5 - 0.8 GeV/c. New structure was observed at k = 0.65 GeV/c. Difference between behavior of T 20 for d p backward elastic scattering and for breakup reaction, which have a smooth behavior of T 20 at high k, is discussed. 12 refs.; 3 figs. (author)

Elliptic hypergeometric integrals and 't Hooft anomaly matching conditions

International Nuclear Information System (INIS)

Spiridonov, V.P.; Vartanov, G.S.

2012-03-01

Elliptic hypergeometric integrals describe superconformal indices of 4d supersymmetric field theories. We show that all 't Hooft anomaly matching conditions for Seiberg dual theories can be derived from SL(3, Z)-modular transformation properties of the kernels of dual indices.

Highly enriched Betaproteobacteria growing anaerobically with p-xylene and nitrate

DEFF Research Database (Denmark)

Rotaru, Amelia-Elena; Probian, Christina; Wilkes, Heinz

2010-01-01

The identity of the microorganisms capable of anaerobic p-xylene degradation under denitrifying conditions is hitherto unknown. Here, we report highly enriched cultures of freshwater denitrifying bacteria that grow anaerobically with p-xylene as the sole organic carbon source and electron donor. ...

Measurement of event-by-event transverse momentum and multiplicity fluctuations using strongly intensive measures $\\Delta[P_T, N]$ and $\\Sigma[P_T, N]$ in nucleus-nucleus collisions at the CERN Super Proton Synchrotron

CERN Document Server

Anticic, T.; Bartke, J.; Beck, H.; Betev, L.; Białkowska, H.; Blume, C.; Boimska, B.; Book, J.; Botje, M.; Bunčić, P.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, J.; Eckardt, V.; Fodor, Z.; Foka, P.; Friese, V.; Gaździcki, M.; Grebieszkow, K.; Höhne, C.; Kadija, K.; Karev, A.; Kolesnikov, V.; Kowalski, M.; Kresan, D.; Laszlo, A.; Lacey, R.; van Leeuwen, M.; Maćkowiak-Pawłowska, M.; Makariev, M.; Malakhov, A.; Melkumov, G.; Mitrovski, M.; Mrówczyński, S.; Pálla, G.; Panagiotou, A.; Pluta, J.; Prindle, D.; Pühlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rybczyński, M.; Rybicki, A.; Sandoval, A.; Rustamov, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Siklér, F.; Skrzypczak, E.; Słodkowski, M.; Stefanek, G.; Stock, R.; Ströbele, H.; Susa, T.; Szuba, M.; Varga, D.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Vranić, D.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.

2015-10-12

Results from the NA49 experiment at the CERN SPS are presented on event-by-event transverse momentum and multiplicity fluctuations of charged particles, produced at forward rapidities in central Pb+Pb interactions at beam momenta 20$A$, 30$A$, 40$A$, 80$A$, and 158$A$ GeV/c, as well as in systems of different size ($p+p$, C+C, Si+Si, and Pb+Pb) at 158$A$ GeV/c. This publication extends the previous NA49 measurements of the strongly intensive measure $\\Phi_{p_T}$ by a study of the recently proposed strongly intensive measures of fluctuations $\\Delta[P_T, N]$ and $\\Sigma[P_T, N]$. In the explored kinematic region transverse momentum and multiplicity fluctuations show no significant energy dependence in the SPS energy range. However, a remarkable system size dependence is observed for both $\\Delta[P_T, N]$ and $\\Sigma[P_T, N]$, with the largest values measured in peripheral Pb+Pb interactions. The results are compared with NA61/SHINE measurements in $p+p$ collisions, as well as with predictions of the UrQMD and ...

The (p, ρ, T) of (methanol + benzene) and (methanol + ethylbenzene)

International Nuclear Information System (INIS)

Naziev, Yashar M.; Shahverdiyev, Astan N.; Hasanov, Vaqif H.

2005-01-01

The (p, ρ, T) of methanol, ethylbenzene and (methanol + benzene) and (methanol + ethylbenzene) at temperatures between (290 and 500) K and pressures in the range (0.1 to 60) MPa have been measured with a magnetic suspension densimeter with an uncertainty of ±0.1%. Our measurements with methanol deviate from the literature values by less than 0.2%. The (p, ρ, T) measurements were fitted with experimental uncertainties by an empirical equation. The temperature and mole fraction dependence of the coefficients of the equation of state are presented

Azimuthal correlations of high-pT photons and hadrons in Au+Au collisions at STAR

International Nuclear Information System (INIS)

Dietel, T.

2006-01-01

The STAR experiment observed a modification of the azimuthal correlations between a trigger particle and associated particles in central Au+Au collisions, where trigger particles with 4 GeV T trigger T trigger <4 GeV were selected. This thesis studies azimuthal correlations between regions of high energy deposition in the electro-magnetic calorimeter as trigger- and charged tracks as associated particles. The data sample had been enriched by online event selection, allowing for the selection of trigger particles with a transverse energy of more than 10 GeV and associated particles with more than 2, 3 or 4 GeV. The trigger particles are a mixture of photon pairs from the decays of neutral pions and single photons, mainly from photon-jet events, with small contributions from other hadron decays and fragmentation photons. (orig.)

A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells).

Science.gov (United States)

Yoshida, Naohiro; Kinugasa, Tetsushi; Miyoshi, Hiroaki; Sato, Kensaku; Yuge, Kotaro; Ohchi, Takafumi; Fujino, Shinya; Shiraiwa, Sachiko; Katagiri, Mitsuhiro; Akagi, Yoshito; Ohshima, Koichi

2016-03-01

Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis. The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed. A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (p = 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (p = 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (p = 0.04; hazard ratio [HR], 1.84; 95% confidence interval [CI] 1.02-3.45). This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.

Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras

International Nuclear Information System (INIS)

Rueedi, E.S.; Sykes, M.; Ildstad, S.T.; Chester, C.H.; Althage, A.; Hengartner, H.; Sachs, D.H.; Zinkernagel, R.M.

1989-01-01

Mixed irradiation bone marrow chimeras were prepared by reconstituting lethally irradiated C57BL/10 (B10) or B10.D2 mice with T cell-depleted bone marrow cells of B10 plus B10.D2 origin. These chimeras were healthy and survived well under conventional housing conditions and after experimental laboratory infections. Of a total of 17 chimeras tested, 2 died spontaneously or from the injected virus. Twelve of fifteen chimeras mounted a measurable cytotoxic T cell response to virus. Despite approximately equal percentages of B10 and B10.D2 lymphocytes in chimeras, cytotoxic T cell responses to vaccinia virus and lymphocytic choriomeningitis virus were mediated variably by either syngeneic or allogeneic donor lymphocytes; thus the H-2 type of effector T cells frequently did not correspond to the 50:50 distribution of spleen or peripheral blood lymphocytes. Cytotoxic responses were restricted exclusively to recipient H-2 type. All mixed chimeras examined were able to mount a good IgG response to vesicular stomatitis virus. These results confirm previous data suggesting that such mixed chimeras are healthy and immunocompetent and demonstrate strict recipient-determined restriction specificity of effector T cells; they also suggest that if T help is necessary for induction of virus-specific cytotoxic T cells, it does not require host-restricted interactions between helper T cells and precursor cytotoxic T cells

High-precision (p,t) reactions to determine reaction rates of explosive stellar processes

NARCIS (Netherlands)

Matić, Andrija

2007-01-01

The aim of my study was to investigate the nuclear structure of 22Mg and 26Si. These two nuclei play a significant role in stellar reaction processes at high temperatures. On base of the obtained nuclear structure we calculated the stellar reaction rates for the following reactions: 18Ne(α,p)21Na,

Photoeffect on the p-n silicon junction under conditions of interband heating of carriers by light

Energy Technology Data Exchange (ETDEWEB)

Andrianov, A V; Valov, P M; Sukhanov, V L; Tuchkevich, V V; Shmidt, N M [AN SSSR, Leningrad. Fiziko-Tekhnicheskij Inst.

1980-05-01

Photoeffect on the p-n silicon junction conditioned by interband heating of carriers by the CO/sub 2/-laser light has been studied experimentally at room temperature and under nonstationary conditions. Photoelectromotive force (p.e.m.f.) with the sign opposite to the value p.e.m.f. appears in the case of direct displacement of p-n structures. The p.e.m.f. value increases with the increase of direct desplacement. Photoelectrons are shown to make the main contribution into the mechanism of p.e.m.f. formation. Lateral p.e.m.f. connected with spreading currents in the direction parallel to the surface of the p-n junction appears in the p-n structure base. It has been found out that structures with highly alloyed emitter at reverse displacement operates under standard photodiod conditions, that is due to the semiconductor lattice heating by CO/sub 2/-laser irradiation.

Photoeffect on the p-n silicon junction under conditions of interband heating of carriers by light

International Nuclear Information System (INIS)

Andrianov, A.V.; Valov, P.M.; Sukhanov, V.L.; Tuchkevich, V.V.; Shmidt, N.M.

1980-01-01

Photoeffect on the p-n silicon junction conditioned by interband heating of carriers by the CO 2 -laser light has been studied experimentally at room temperature and under nonstationary conditions. Photoelectromotive force (p.e.m.f.) with the sign opposite to the value p.e.m.f. appears in the case of direct displacement of p-n structures. The p.e.m.f. value increases with the increase of direct desplacement. Photoelectrons are shown to make the main contribution into the mechanism of p.e.m.f. formation. Lateral p.e.m.f. connected with spreading currents in the direction parallel to the surface of the p-n junction appears in the p-n structure base. It has been found out that structures with highly alloyed emitter at reverse displacement operates under standard photodiod conditions, that is due to the semiconductor lattice heating by CO 2 -laser irradiation

Le projet français P.I.V.E.R.T.

Directory of Open Access Journals (Sweden)

Rous Jean-François

2012-11-01

Full Text Available P.I.V.E.R.T. is an ambitious project of development of the 3rd generation biorefinery by 2020. Conceived around a technological complex with strict environmental criteria (aiming at obtaining a label HQE, P.I.V.E.R.T. federates all the national and main roads lifeblood, of the sector (some international partnerships are also under development. The major objectives of the P.I.V.E.R.T. project are: a valorization of oilseeds, proteins and lignocellulosic plant in its entirety (approach ‘‘entire plants’’ ; an operation in closed circuit on the level of water and energy exchanges, the platform providing for its own needs, in a logic of industrial ecology ; collection and valorization of a significant part of the CO2 produced by the activities of the refinery. Two strategies will be developed jointly: on one hand the development of ‘‘platform’’ molecules entering the traditional circuits of chemistry, on the current markets with the renewable character, in addition, the development of new molecules having new properties, thus giving access to new markets. Thanks to the research and development realized by researchers dedicated to P.I.V.E.R.T., the industrial partners will have access to a capable structure to develop, and to test demonstrators preceding future industrial production units. Certain technological bricks could be tested in a large scale industrial platform dedicated to operational integration of innovations. The development of programming technologies of refineries will give to P.I.V.E.R.T. the means to develop new innovative processes and will give to the industrials the possibility of modeling their future production units.

Molecular and clinical description of a girl with a 46,X,t(Y;4)(q11.2;p16)/45,X,der(4)t(Y;4)(q11.2;p16) karyotype and a small cryptic 4p subtelomeric deletion.

Science.gov (United States)

Zahed, Laila; Sismani, Carolina; Ioannides, M; Saleh, Monzer; Koumbaris, G; Kenj, Mazen; Abdallah, Amal; Ayyache, Maya; Patsalis, Philippos

2008-04-01

We report on a 13-year-old female with short stature, minimal axillary and pubic hair, no breast development, absence of uterus and ovaries, with the following karyotype on lymphocyte cultures: 46,X,t(Y;4)(q11.2;p16)[40]/45,X,der(4)t(Y;4)(q11.2;p16)[10]. Loss of the small derivative Y chromosome in 20% of the cells was also confirmed in skin fibroblast cultures. FISH analyses using Y centromere, SRY, subtelomere XpYp/XqYq, Y and 4 painting probes, confirmed the cytogenetic findings. High-resolution STS analyses using 40 markers covering the Y chromosome did not identify any deletion on the Y. However, de novo absence of the 4p subtelomeric region was noted by FISH, although this deletion was not revealed by Array-CGH at 1 Mb resolution, the last array clone being 0.35 or 1 Mb distal to the 4p FISH probe. The female phenotype of this patient must be due to the loss of the derivative Y chromosomes in some of her cells, especially the gonads, while the 4p subtelomeric deletion does not seem to contribute to her phenotype. Copyright 2008 Wiley-Liss, Inc.

Solvability of a (p, n-p-type multi-point boundary-value problem for higher-order differential equations

Directory of Open Access Journals (Sweden)

Yuji Liu

2003-12-01

Full Text Available In this article, we study the differential equation $$ (-1^{n-p} x^{(n}(t=f(t,x(t,x'(t,dots,x^{(n-1}(t, $$ subject to the multi-point boundary conditions $$displaylines{ x^{(i}(0=0 quad hbox{for }i=0,1,dots,p-1,cr x^{(i}(1=0 quad hbox{for }i=p+1,dots,n-1,cr sum_{i=1}^malpha_ix^{(p}(xi_i=0, }$$ where $1le ple n-1$. We establish sufficient conditions for the existence of at least one solution at resonance and another at non-resonance. The emphasis in this paper is that $f$ depends on all higher-order derivatives. Examples are given to illustrate the main results of this article.

T-p phase diagrams and the barocaloric effect in materials with successive phase transitions

Science.gov (United States)

Gorev, M. V.; Bogdanov, E. V.; Flerov, I. N.

2017-09-01

An analysis of the extensive and intensive barocaloric effect (BCE) at successive structural phase transitions in some complex fluorides and oxyfluorides was performed. The high sensitivity of these compounds to a change in the chemical pressure allows one to vary the succession and parameters of the transformations (temperature, entropy, baric coefficient) over a wide range and obtain optimal values of the BCE. A comparison of different types of schematic T-p phase diagrams with the complicated T( p) dependences observed experimentally shows that in some ranges of temperature and pressure the BCE in compounds undergoing successive transformations can be increased due to a summation of caloric effects associated with distinct phase transitions. The maximum values of the extensive and intensive BCE in complex fluorides and oxyfluorides can be realized at rather low pressure (0.1-0.3 GPa). In a narrow temperature range around the triple points conversion from conventional BCE to inverse BCE is observed, which is followed by a gigantic change of both \\vertΔ S_BCE\\vert and \\vertΔ T_AD\\vert .

Uterine Artery Embolization for Symptomatic Fibroids with High Signal Intensity on T2-Weighted MR Imaging

Energy Technology Data Exchange (ETDEWEB)

Chang, Suyon; Kim, Man Deuk; Lee, Myung Su; Lee, Mu Sook; Park, Sung Il; Won, Jong Yun; Lee, Do Yun; Lee, Kwang Hun [Dept. of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Severance Hospital, Seoul (Korea, Republic of)

2012-09-15

To evaluate the effectiveness of uterine artery embolization (UAE) for treating symptomatic fibroids with high signal intensity (SI) on magnetic resonance (MR) T2-weighted imaging (T2WI). A total of 537 cases, consisting of 14 patients with high SI fibroids on T2WI (T2 high group), were retrospectively included and compared with 28 randomly selected patients with low SI fibroids on T2WI (control group). High SI of a predominant fibroid on T2WI was defined as having the same or higher SI than the myometrium. Patient ages ranged from 28 to 52 years (mean, 38.1 years). All patients underwent MRI before and after UAE. Predominant fibroid and uterine volumes were calculated with MR images. Symptom status in terms of menorrhagia and dysmenorrhea was scored on a scale of 0-10, with 0 being no symptoms and 10 being the baseline, or initial symptoms. Of the patients in the T2 high group, 13 out of 14 (92.9%) patients demonstrated complete necrosis of the predominant fibroids. The mean volume reduction rates of the predominant fibroids in the T2 high group was 61.7% at three months after UAE, which was significantly higher than the volume reduction rates of 42.1% noted in the control group (p < 0.05). Changes in symptom scores for menorrhagia and dysmenorrhea after UAE (baseline score minus follow-up score) were 4.9 and 7.5 in T2 high group and they were 5.0 and 7.7 in control group, suggesting a significant resolution of symptoms (p < 0.01) in both groups but no significant difference between the two groups. UAE is effective for uttering fibroids showing high SI on T2WI. The mean volume reduction rate of the predominant fibroids three months after UAE was greater in the T2 high group than in the control group.

Uterine Artery Embolization for Symptomatic Fibroids with High Signal Intensity on T2-Weighted MR Imaging

International Nuclear Information System (INIS)

Chang, Suyon; Kim, Man Deuk; Lee, Myung Su; Lee, Mu Sook; Park, Sung Il; Won, Jong Yun; Lee, Do Yun; Lee, Kwang Hun

2012-01-01

To evaluate the effectiveness of uterine artery embolization (UAE) for treating symptomatic fibroids with high signal intensity (SI) on magnetic resonance (MR) T2-weighted imaging (T2WI). A total of 537 cases, consisting of 14 patients with high SI fibroids on T2WI (T2 high group), were retrospectively included and compared with 28 randomly selected patients with low SI fibroids on T2WI (control group). High SI of a predominant fibroid on T2WI was defined as having the same or higher SI than the myometrium. Patient ages ranged from 28 to 52 years (mean, 38.1 years). All patients underwent MRI before and after UAE. Predominant fibroid and uterine volumes were calculated with MR images. Symptom status in terms of menorrhagia and dysmenorrhea was scored on a scale of 0-10, with 0 being no symptoms and 10 being the baseline, or initial symptoms. Of the patients in the T2 high group, 13 out of 14 (92.9%) patients demonstrated complete necrosis of the predominant fibroids. The mean volume reduction rates of the predominant fibroids in the T2 high group was 61.7% at three months after UAE, which was significantly higher than the volume reduction rates of 42.1% noted in the control group (p < 0.05). Changes in symptom scores for menorrhagia and dysmenorrhea after UAE (baseline score minus follow-up score) were 4.9 and 7.5 in T2 high group and they were 5.0 and 7.7 in control group, suggesting a significant resolution of symptoms (p < 0.01) in both groups but no significant difference between the two groups. UAE is effective for uttering fibroids showing high SI on T2WI. The mean volume reduction rate of the predominant fibroids three months after UAE was greater in the T2 high group than in the control group.

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.

Science.gov (United States)

Sugita, Sunao; Horie, Shintaro; Nakamura, Orie; Maruyama, Kazuichi; Takase, Hiroshi; Usui, Yoshihiko; Takeuchi, Masaru; Ishidoh, Kazumi; Koike, Masato; Uchiyama, Yasuo; Peters, Christoph; Yamamoto, Yoshimi; Mochizuki, Manabu

2009-10-15

Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment epithelium (RPE) converts CD4(+) T cells into Treg cells in vitro. RPE constitutively expresses a novel immunosuppressive factor, CTLA-2alpha, which is a cathepsin L (CathL) inhibitor, and this molecule acts via RPE to induce Treg cells. To clarify CTLA-2alpha's role in the T cell response to RPE in ocular inflammation, we used the experimental autoimmune uveitis (EAU) animal model to examine this new immunosuppressive property of RPE. In EAU models, TGF-beta, but not IFN-gamma inflammatory cytokines, promotes the up-regulation of the expression of CTLA-2alpha in RPE. Similarly, CTLA-2alpha via RPE was able to promote TGF-beta production by the CD4(+) T cells. The RPE-exposed T cells (RPE-induced Treg cells) greatly produced TGF-beta and suppressed bystander effector T cells. There was less expression of CathL by the RPE-exposed T cells, and CathL-inhibited T cells were able to acquire the Treg phenotype. Moreover, CathL-deficient mice spontaneously produced Treg cells, with the increase in T cells potentially providing protection against ocular inflammation. More importantly, CD4(+) T cells from EAU in CathL knockout mice or rCTLA-2alpha from EAU animals were found to contain a high population of forkhead box p3(+) T cells. In both EAU models, there was significant suppression of the ocular inflammation. These results indicate that RPE secretes CTLA-2alpha, thereby enabling the bystander T cells to be converted into Treg cells via TGF-beta promotion.

Ethanol and anaerobic conditions reversibly inhibit commercial cellulase activity in thermophilic simultaneous saccharification and fermentation (tSSF

Directory of Open Access Journals (Sweden)

Podkaminer Kara K

2012-06-01

Full Text Available Abstract Background A previously developed mathematical model of low solids thermophilic simultaneous saccharification and fermentation (tSSF with Avicel was unable to predict performance at high solids using a commercial cellulase preparation (Spezyme CP and the high ethanol yield Thermoanaerobacterium saccharolyticum strain ALK2. The observed hydrolysis proceeded more slowly than predicted at solids concentrations greater than 50 g/L Avicel. Factors responsible for this inaccuracy were investigated in this study. Results Ethanol dramatically reduced cellulase activity in tSSF. At an Avicel concentration of 20 g/L, the addition of ethanol decreased conversion at 96 hours, from 75% in the absence of added ethanol down to 32% with the addition of 34 g/L initial ethanol. This decrease is much greater than expected based on hydrolysis inhibition results in the absence of a fermenting organism. The enhanced effects of ethanol were attributed to the reduced, anaerobic conditions of tSSF, which were shown to inhibit cellulase activity relative to hydrolysis under aerobic conditions. Cellulose hydrolysis in anaerobic conditions was roughly 30% slower than in the presence of air. However, this anaerobic inhibition was reversed by exposing the cellulase enzymes to air. Conclusion This work demonstrates a previously unrecognized incompatibility of enzymes secreted by an aerobic fungus with the fermentation conditions of an anaerobic bacterium and suggests that enzymes better suited to industrially relevant fermentation conditions would be valuable. The effects observed may be due to inactivation or starvation of oxygen dependent GH61 activity, and manipulation or replacement of this activity may provide an opportunity to improve biomass to fuel process efficiency.

The German P and T Study: Results and Conclusions in the View of the Contributing Helmholtz Research Centres

International Nuclear Information System (INIS)

Merk, B.; Geist, A.; Knebel, J.; Modolo, G.

2015-01-01

The decision to phase out electric energy production in nuclear power plants in Germany has put some questions on the future of P and T research. The Federal Ministry for Economic Affairs and Energy and the Federal Ministry of Education and Research have launched a study managed by the National Academy of Science and Engineering to answer these questions on a broad scientific basis. The major mandate was to evaluate scientific and technological as well as socio-economic challenges and opportunities of the P and T technology in the view of the phase out decision, both in a national and an international context. The scientific and technological aspects of P and T are analysed with respect to a possible contribution to the management of nuclear waste, using the following structure: - Starting point and boundary conditions - waste amounts and final disposal strategies. - Definition and description of scenarios - possible ways for transmutation; European vs. national. - Technology challenges of P and T - description of the major challenges to be solved on the way to a possible industrial application. - Current status of R and D - discussion of possible transmutation systems, current R and D status of P and T, technology gaps and future research strategies. - Safety aspects - dedicated safety aspects including all steps of the P and T cycle. - International projects and competences in Germany - what is going on around the world and which support could come from the German industry? In parallel, the socio-scientific, the ecologic and the economic aspects have been analysed using expert interviews, group Delphi and independent expert opinions on economic, legal and environmental aspects. An overview of the study's results will be given from the viewpoint of the contributing Helmholtz research centres at Juelich (FZJ), Dresden-Rossendorf (HZDR) and Karlsruhe (KIT), with a focus on the research-political recommendations and the developed research strategy proposed to

Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Münster AML-study group

Science.gov (United States)

Coenen, Eva A.; Zwaan, C. Michel; Reinhardt, Dirk; Harrison, Christine J.; Haas, Oskar A.; de Haas, Valerie; Mihál, Vladimir; De Moerloose, Barbara; Jeison, Marta; Rubnitz, Jeffrey E.; Tomizawa, Daisuke; Johnston, Donna; Alonzo, Todd A.; Hasle, Henrik; Auvrignon, Anne; Dworzak, Michael; Pession, Andrea; van der Velden, Vincent H. J.; Swansbury, John; Wong, Kit-fai; Terui, Kiminori; Savasan, Sureyya; Winstanley, Mark; Vaitkeviciene, Goda; Zimmermann, Martin; Pieters, Rob; van den Heuvel-Eibrink, Marry M.

2013-01-01

In pediatric acute myeloid leukemia (AML), cytogenetic abnormalities are strong indicators of prognosis. Some recurrent cytogenetic abnormalities, such as t(8;16)(p11;p13), are so rare that collaborative studies are required to define their prognostic impact. We collected the clinical characteristics, morphology, and immunophenotypes of 62 pediatric AML patients with t(8;16)(p11;p13) from 18 countries participating in the International Berlin-Frankfurt-Münster (I-BFM) AML study group. We used the AML-BFM cohort diagnosed from 1995-2005 (n = 543) as a reference cohort. Median age of the pediatric t(8;16)(p11;p13) AML patients was significantly lower (1.2 years). The majority (97%) had M4-M5 French-American-British type, significantly different from the reference cohort. Erythrophagocytosis (70%), leukemia cutis (58%), and disseminated intravascular coagulation (39%) occurred frequently. Strikingly, spontaneous remissions occurred in 7 neonates with t(8;16)(p11;p13), of whom 3 remain in continuous remission. The 5-year overall survival of patients diagnosed after 1993 was 59%, similar to the reference cohort (P = .14). Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML. Highly expressed genes included HOXA11, HOXA10, RET, PERP, and GGA2. In conclusion, pediatric t(8;16)(p11;p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features in whom spontaneous remissions occur in a subset of neonatal cases. PMID:23974201

Wildtype p53-specific Antibody and T-Cell Responses in Cancer Patients

DEFF Research Database (Denmark)

Pedersen, Anders Elm; Stryhn, Anette; Justesen, Sune

2011-01-01

patients. Detection of antibodies against wt p53 protein has been used as a diagnostic and prognostic marker and discovery of new T-cell epitopes has enabled design of cancer vaccination protocols with promising results. Here, we identified wt p53-specific antibodies in various cancer patients......(264-272) in breast cancer patients and against HLA-A*01:01 binding peptide wt p53(226-234) and HLA-B*07:02 binding peptide wt p53(74-82) in renal cell cancer and breast cancer patients, respectively. Finally, we analyzed antibody and T-cell responses against wt p53 15-mer peptides in patients with metastatic renal...

P, ρ, and T measurements of the (limonene + β-pinene) mixtures

International Nuclear Information System (INIS)

Langa, Elisa; Palavra, Antonio M.F.; Nieto de Castro, Carlos A.; Mainar, Ana M.

2012-01-01

Highlights: ► Density as a function of P, T and composition was measured for pinene mixtures. ► Isothermal compressibility and coefficients of cubic expansion were also calculated. ► Usual behaviour of these three properties was found. ► SAFT and PC-SAFT were used as predictive models, showing PC-SAFT the best predictions. - Abstract: The density, ρ, and two derived properties, isothermal compressibility, κ T , and the coefficient of cubic expansion, α P , were obtained for the mixtures of 1-methyl-4-(1-methylethenyl)-cyclohexene, known as limonene, and (1S,5S)-6,6-dimethyl-2-methylenebibyclo[3.1.1]heptane, known as β-pinene, for nine different compositions and the pure components at five pressures from 20 MPa to 40 MPa and six temperatures from 283.15 K to 358.15 K. The experimental uncertainty for ρ, κ T , and α P were respectively ±0.5 kg · m −3 , ±14 TPa −1 , and ±0.005k K −1 , with k = 2 for all of them. Density behaviour with temperature and pressure was as expected. The values of α P and κ T increase with temperature and decrease with increasing pressure. Two different equations of state, conventional SAFT and PC-SAFT, were applied to predict the densities of the mixture. The best predictions were achieved with PC-SAFT.

Universal scaling of strange particle pT spectra in pp collisions

Science.gov (United States)

Yang, Liwen; Wang, Yanyun; Hao, Wenhui; Liu, Na; Du, Xiaoling; Zhang, Wenchao

2018-04-01

As a complementary study to that performed on the transverse momentum (pT) spectra of charged pions, kaons and protons in proton-proton (pp) collisions at LHC energies 0.9, 2.76 and 7TeV, we present a scaling behaviour in the pT spectra of strange particles (KS0, Λ, Ξ and φ) at these three energies. This scaling behaviour is exhibited when the spectra are expressed in a suitable scaling variable z=pT/K, where the scaling parameter K is determined by the quality factor method and increases with the center of mass energy (√{s}). The rates at which K increases with ln √{s} for these strange particles are found to be identical within errors. In the framework of the colour string percolation model, we argue that these strange particles are produced through the decay of clusters that are formed by the colour strings overlapping. We observe that the strange mesons and baryons are produced from clusters with different size distributions, while the strange mesons (baryons) KS0 and φ ( Λ and Ξ) originate from clusters with the same size distributions. The cluster's size distributions for strange mesons are more dispersed than those for strange baryons. The scaling behaviour of the pT spectra for these strange particles can be explained by the colour string percolation model in a quantitative way.

File list: InP.Bld.50.AllAg.Naive_T_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available InP.Bld.50.AllAg.Naive_T_cells hg19 Input control Blood Naive T cells SRX1425815,SR...X1425816,SRX1425814 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.50.AllAg.Naive_T_cells.bed ...

High-E{sub T} dijet photoproduction at HERA

Energy Technology Data Exchange (ETDEWEB)

Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (US)] (and others)

2007-06-15

The cross section for high-E{sub T} dijet production in photoproduction has been measured with the ZEUS detector at HERA using an integrated luminosity of 81.8 pb{sup -1}. The events were required to have a virtuality of the incoming pho- ton, Q{sup 2}, of less than 1 GeV{sup 2} and a photon-proton centre-of-mass energy in the range 142p}<293 GeV. Events were selected if at least two jets satisfied the transverse-energy requirements of E{sub T}{sup jet1}>20 GeV and E{sub T}{sup jet2}>15 GeV and pseudorapidity requirements of -1<{eta}{sup jet1,2}<3, with at least one of the jets satisfying -1<{eta}{sup jet}<2.5. The measurements show sensitivity to the parton distributions in the photon and proton and effects beyond next-to-leading order in QCD. Hence these data can be used to constrain further the parton densities in the proton and photon. (orig.)

Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes

Directory of Open Access Journals (Sweden)

Feuer Gerold

2004-11-01

Full Text Available Abstract Background Human T-lymphotropic virus type-1 (HTLV-1 is a deltaretrovirus that causes adult T-cell leukemia/lymphoma and is implicated in a variety of lymphocyte-mediated disorders. HTLV-1 contains both regulatory and accessory genes in four pX open reading frames. pX ORF-II encodes two proteins, p13II and p30II, which are incompletely defined in the virus life cycle or HTLV-1 pathogenesis. Proviral clones of the virus with pX ORF-II mutations diminish the ability of the virus to maintain viral loads in vivo. Exogenous expression of p30II differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein/p300 and represses tax/rex RNA nuclear export. Results Herein, we further characterized the role of p30II in regulation of cellular gene expression, using stable p30II expression system employing lentiviral vectors to test cellular gene expression with Affymetrix U133A arrays, representing ~33,000 human genes. Reporter assays in Jurkat T cells and RT-PCR in Jurkat and primary CD4+ T-lymphocytes were used to confirm selected gene expression patterns. Our data reveals alterations of interrelated pathways of cell proliferation, T-cell signaling, apoptosis and cell cycle in p30II expressing Jurkat T cells. In all categories, p30II appeared to be an overall repressor of cellular gene expression, while selectively increasing the expression of certain key regulatory genes. Conclusions We are the first to demonstrate that p30II, while repressing the expression of many genes, selectively activates key gene pathways involved in T-cell signaling/activation. Collectively, our data suggests that this complex retrovirus, associated with lymphoproliferative diseases, relies upon accessory gene products to modify cellular environment to promote clonal expansion of the virus genome and thus maintain proviral loads in vivo.

Implementation and verification of a coupled fire model as a thermal boundary condition within P3/THERMAL

International Nuclear Information System (INIS)

Hensinger, D.M.; Gritzo, L.A.; Koski, J.A.

1996-01-01

A user-defined boundary condition subroutine has been implemented within P3/THERMAL to represent the heat flux between a noncombusting object and an engulfing fire. The heat flux calculations includes a simple 2D fire model in which energy and radiative heat transport equations are solved to produce estimates of the heat fluxes at the fire-object interface. These estimates reflect radiative coupling between a cold object and the flow of hot combustion gases which has been observed in fire experiments. The model uses a database of experimental pool fire measurements for far field boundary conditions and volumetric heat release rates. Taking into account the coupling between a structure and the fire is an improvement over the σT 4 approximation frequently used as a boundary condition for engineered system response and is the preliminary step in the development of a fire model with a predictive capability. This paper describes the implementation of the fire model as a P3/THERMAL boundary condition and presents the results of a verification calculation carried out using the model

Search for $B^{0}_{s}-\\overline{B^{0}_{s}}$ oscillations in DELPHI using high-$p_{t}$ leptons

CERN Document Server

Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, Borut P; Kerzel, U; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, R; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I; Vegni, G; Veloso, F; Venus, W A; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zinchenko, A I; Zupan, M

2004-01-01

Oscillations in the B0_s - anti-B0_s system were studied in events selected from about 4.3 million hadronic Z^0 decays registered by DELPHI between 1992 and 2000. This paper presents updates of two published analyses ([11,12]). The first analysis, which utilizes leptons emitted with large momentum transverse to a jet, was improved by means of a better algorithm for the vertex reconstuction and a new algorithm for flavour-tagging at production time. The second analysis, which utilizes D_s-lepton events, was improved by optimizing the treatment of proper time resolution. No signal of B0_s oscillations was observed and limits on the mass difference between the physical B0_s states were obtained to be: \\Delta m_s > 8.0 ps^{-1} at the 95% C.L. with a sensitivity of \\Delta m_s = 9.1 ps^{-1} in the high p_t lepton analysis and \\Delta m_s > 4.9 ps^{-1} at the 95% C.L. with a sensitivity of \\Delta m_s = 8.6 ps^{-1} in the D_s-lepton analysis. Previously published results on these analyses are superseed. The combinatio...

Corrosion Behavior and Oxide Film Formation of T91 Steel under Different Water Chemistry Operation Conditions

Energy Technology Data Exchange (ETDEWEB)

Zhang, D. Q.; Shi, C.; Li, J.; Gao, L. X. [Shanghai University of Electric Power, Shanghai (China); Lee, K. Y. [Dalian University of Technology, Dalian (China)

2017-02-15

The corrosion behavior of a ferritic/martensitic steel T91 exposed to an aqueous solution containing chloride and sulfate ions is investigated depending on the stimulated all-volatile treatment (AVT) and under oxygenated treatment (OT) conditions. The corrosion of T91 steel under OT condition is severe, while the corrosion under AVT condition is not. The co-existence of chloride and sulfate ions has antagonistic effect on the corrosion of T91 steel in both AVT and OT conditions. Unlike to corrosion resistance in the aqueous solution, OT pretreatment provides T91 steel lower oxidation-resistance than VAT pretreatment. From scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS) and X-ray diffraction (XRD) analysis, the lower corrosion resistance in the aqueous solution by VAT conditions possibly is due to the formation of pits. In addition, the lower oxidation resistance of T91 steel pretreated by OT conditions is explained as follows: the cracks formed during the immersion under OT conditions accelerated peeling-off rate of the oxide film.

MRI and P-31 Magnetic Resonance Spectroscopy Hardware for Axillary Lymph Node Investigation at 7T

NARCIS (Netherlands)

Rivera, Debra S.; Wijnen, Jannie P.; van der Kemp, Wybe J. M.; Raaijmakers, Alexander J.; Luijten, Peter R.; Klomp, DWJ

PurposeNeoadjuvant treatment response in lymph nodes predicts patient outcome, but existing methods do not track response during therapy accurately. In this study, specialized hardware was used to adapt high-field (7T) P-31 magnetic resonance spectroscopy (MRS), which has been shown to track

Confinement studies of a high current density RFP in the Extrap T1 Upgrade device

International Nuclear Information System (INIS)

Drake, J.R.; Brzozowski, J.H.; Brunsell, P.; Hellblom, G.; Karlsson, P.; Mazur, S.; Nordlund, P.; Welander, A.; Zastrow, K.D.

1992-01-01

Confinement studies have been carried out on the Extrap T1 device operated in the reversed field pinch (RFP) mode. Extrap T1 is a small device with a major radius of R=0.5 m and a high aspect ratio, R/a=8.9. For these experiments, the device has been operated with a resistive shell with measured, toroidally-averaged flux penetration times of τ sv = 500μs (vertical) and τ sR =300μs (radial). The pulse lengths are about 600 μs, which is slightly longer than the shell penetration time. The purpose of these experiments is to study energy confinement in a high aspect-ratio, high current-density RFP device with a resistive shell. The device can be operated with high current densities which exceed 20 MAm -2 on axis. For these discharges, the average electron density is relatively high, ≅ 1x10 20 m -3 . Therefore, although the average current density exceeds 5 MAm -2 , the important parameter / ≅ I/N is maintained less than 1x10 -13 Am, where N is the line density. The plasma diagnostics for the device include a single chord CO 2 laser interferometer ( ), single point Thomson scattering (T e , n o ), VUV and visible spectroscopy (T e , Z eff ) surface barrier diodes for soft X-ray measurements (T e ), bolometry (P rad ), surface probes (Γ p ,T i ) and comprehensive magnetic diagnostics for both equilibrium and magnetic fluctuation studies. (author) 5 refs., 1 fig., 1 tab

Synthesis and Characterization of Chitosan-p-t-Butylcalix[4]arene acid

Science.gov (United States)

Handayani, D. S.; Frimadasi, W.; Kusumaningsih, T.; Pranoto

2018-03-01

The synthesis of chitosan-p-t-butylcalix[4]arene acid was done with DIC (N, N’-diisopropylcarbodiimide) as the coupling agent. The structural analysis of the chitosan-p-t-butylcalix[4]arene acid was conducted by spectrophotometer Fourier Transform Infra Red (FTIR) and X-Ray Diffraction (XRD). Meanwhile, the surface area was investigated by Surface Area Analysis, the Scanning Electrone Microscope (SEM) analysed the surface morphology, and also the melting point temperature was determined. FTIR analysis on Chitosan-p-t-butylcalix[4]arene provides an overlapped absorption of -OH and -NH groups at 3438.26 cm-1. Meanwhile, a C = C aromatic bond present at 1480.43 cm-1. XRD analysis shows some broaden peaks due to the amorphous phase of the prepared material. The prepared material is a brownish yellow solid, odorless and porous. The melting point, surface area, and the average pore radius are above 300 °C, 9.42 m2 / g, and 52.5938 Å, respectively.

Investigation of deep inelastic scattering processes involving large p$_{t}$ direct photons in the final state

CERN Multimedia

2002-01-01

This experiment will investigate various aspects of photon-parton scattering and will be performed in the H2 beam of the SPS North Area with high intensity hadron beams up to 350 GeV/c. \\\\\\\\ a) The directly produced photon yield in deep inelastic hadron-hadron collisions. Large p$_{t}$ direct photons from hadronic interactions are presumably a result of a simple annihilation process of quarks and antiquarks or of a QCD-Compton process. The relative contribution of the two processes can be studied by using various incident beam projectiles $\\pi^{+}, \\pi^{-}, p$ and in the future $\\bar{p}$. \\\\\\\\b) The correlations between directly produced photons and their accompanying hadronic jets. We will examine events with a large p$_{t}$ direct photon for away-side jets. If jets are recognised their properties will be investigated. Differences between a gluon and a quark jet may become observable by comparing reactions where valence quark annihilations (away-side jet originates from a gluon) dominate over the QDC-Compton...

Measurement of the jet mass in highly boosted $\\mathrm{ t \\bar{t} }$ events from pp collisions at $\\sqrt{s}=$ 8 TeV

CERN Document Server

Sirunyan, Albert M; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Dvornikov, Oleg; Makarenko, Vladimir; Mossolov, Vladimir; Suarez Gonzalez, Juan; Zykunov, Vladimir; Shumeiko, Nikolai; Alderweireldt, Sara; De Wolf, Eddi A; Janssen, Xavier; Lauwers, Jasper; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Lowette, Steven; Moortgat, Seth; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Skovpen, Kirill; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Parijs, Isis; Brun, Hugues; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Goldouzian, Reza; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Luetic, Jelena; Maerschalk, Thierry; Marinov, Andrey; Randle-conde, Aidan; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Vannerom, David; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Cimmino, Anna; Cornelis, Tom; Dobur, Didar; Fagot, Alexis; Gul, Muhammad; Khvastunov, Illia; Poyraz, Deniz; Salva Diblen, Sinem; Schöfbeck, Robert; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Bakhshiansohi, Hamed; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Caudron, Adrien; De Visscher, Simon; Delaere, Christophe; Delcourt, Martin; Francois, Brieuc; Giammanco, Andrea; Jafari, Abideh; Komm, Matthias; Krintiras, Georgios; Lemaitre, Vincent; Magitteri, Alessio; Mertens, Alexandre; Musich, Marco; Piotrzkowski, Krzysztof; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Wertz, Sébastien; Beliy, Nikita; Aldá Júnior, Walter Luiz; Alves, Fábio Lúcio; Alves, Gilvan; Brito, Lucas; Hensel, Carsten; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Melo Da Costa, Eliza; Da Silveira, Gustavo Gil; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mora Herrera, Clemencia; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Torres Da Silva De Araujo, Felipe; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Fang, Wenxing; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Chen, Ye; Cheng, Tongguang; Jiang, Chun-Hua; Leggat, Duncan; Liu, Zhenan; Romeo, Francesco; Ruan, Manqi; Shaheen, Sarmad Masood; Spiezia, Aniello; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Zhao, Jingzhou; Ban, Yong; Chen, Geng; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; González Hernández, Carlos Felipe; Ruiz Alvarez, José David; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Sculac, Toni; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Ferencek, Dinko; Kadija, Kreso; Mesic, Benjamin; Susa, Tatjana; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Tsiakkouri, Demetra; Finger, Miroslav; Finger Jr, Michael; Carrera Jarrin, Edgar; Abdelalim, Ahmed Ali; Mohammed, Yasser; Salama, Elsayed; Kadastik, Mario; Perrini, Lucia; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Jarvinen, Terhi; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Ghosh, Saranya; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Kucher, Inna; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Abdulsalam, Abdulla; Antropov, Iurii; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Cadamuro, Luca; Chapon, Emilien; Charlot, Claude; Davignon, Olivier; Granier de Cassagnac, Raphael; Jo, Mihee; Lisniak, Stanislav; Miné, Philippe; Nguyen, Matthew; Ochando, Christophe; Ortona, Giacomo; Paganini, Pascal; Pigard, Philipp; Regnard, Simon; Salerno, Roberto; Sirois, Yves; Stahl Leiton, Andre Govinda; Strebler, Thomas; Yilmaz, Yetkin; Zabi, Alexandre; Zghiche, Amina; Agram, Jean-Laurent; Andrea, Jeremy; Aubin, Alexandre; Bloch, Daniel; Brom, Jean-Marie; Buttignol, Michael; Chabert, Eric Christian; Chanon, Nicolas; Collard, Caroline; Conte, Eric; Coubez, Xavier; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Le Bihan, Anne-Catherine; Van Hove, Pierre; Gadrat, Sébastien; Beauceron, Stephanie; Bernet, Colin; Boudoul, Gaelle; Carrillo Montoya, Camilo Andres; Chierici, Roberto; Contardo, Didier; Courbon, Benoit; Depasse, Pierre; El Mamouni, Houmani; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Grenier, Gérald; Ille, Bernard; Lagarde, Francois; Laktineh, Imad Baptiste; Lethuillier, Morgan; Mirabito, Laurent; Pequegnot, Anne-Laure; Perries, Stephane; Popov, Andrey; Sabes, David; Sordini, Viola; Vander Donckt, Muriel; Verdier, Patrice; Viret, Sébastien; Khvedelidze, Arsen; Tsamalaidze, Zviad; Autermann, Christian; Beranek, Sarah; Feld, Lutz; Kiesel, Maximilian Knut; Klein, Katja; Lipinski, Martin; Preuten, Marius; Schomakers, Christian; Schulz, Johannes; Verlage, Tobias; Albert, Andreas; Brodski, Michael; Dietz-Laursonn, Erik; Duchardt, Deborah; Endres, Matthias; Erdmann, Martin; Erdweg, Sören; Esch, Thomas; Fischer, Robert; Güth, Andreas; Hamer, Matthias; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Knutzen, Simon; Merschmeyer, Markus; Meyer, Arnd; Millet, Philipp; Mukherjee, Swagata; Olschewski, Mark; Padeken, Klaas; Pook, Tobias; Radziej, Markus; Reithler, Hans; Rieger, Marcel; Scheuch, Florian; Sonnenschein, Lars; Teyssier, Daniel; Thüer, Sebastian; Cherepanov, Vladimir; Flügge, Günter; Kargoll, Bastian; Kress, Thomas; Künsken, Andreas; Lingemann, Joschka; Müller, Thomas; Nehrkorn, Alexander; Nowack, Andreas; Pistone, Claudia; Pooth, Oliver; Stahl, Achim; Aldaya Martin, Maria; Arndt, Till; Asawatangtrakuldee, Chayanit; Beernaert, Kelly; Behnke, Olaf; Behrens, Ulf; Bin Anuar, Afiq Aizuddin; Borras, Kerstin; Campbell, Alan; Connor, Patrick; Contreras-Campana, Christian; Costanza, Francesco; Diez Pardos, Carmen; Dolinska, Ganna; Eckerlin, Guenter; Eckstein, Doris; Eichhorn, Thomas; Eren, Engin; Gallo, Elisabetta; Garay Garcia, Jasone; Geiser, Achim; Gizhko, Andrii; Grados Luyando, Juan Manuel; Grohsjean, Alexander; Gunnellini, Paolo; Harb, Ali; Hauk, Johannes; Hempel, Maria; Jung, Hannes; Kalogeropoulos, Alexis; Karacheban, Olena; Kasemann, Matthias; Keaveney, James; Kleinwort, Claus; Korol, Ievgen; Krücker, Dirk; Lange, Wolfgang; Lelek, Aleksandra; Lenz, Teresa; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Mankel, Rainer; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Pitzl, Daniel; Placakyte, Ringaile; Raspereza, Alexei; Roland, Benoit; Sahin, Mehmet Özgür; Saxena, Pooja; Schoerner-Sadenius, Thomas; Spannagel, Simon; Stefaniuk, Nazar; Van Onsem, Gerrit Patrick; Walsh, Roberval; Wissing, Christoph; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Dreyer, Torben; Garutti, Erika; Gonzalez, Daniel; Haller, Johannes; Hoffmann, Malte; Junkes, Alexandra; Klanner, Robert; Kogler, Roman; Kovalchuk, Nataliia; Lapsien, Tobias; Marchesini, Ivan; Marconi, Daniele; Meyer, Mareike; Niedziela, Marek; Nowatschin, Dominik; Pantaleo, Felice; Peiffer, Thomas; Perieanu, Adrian; Scharf, Christian; Schleper, Peter; Schmidt, Alexander; Schumann, Svenja; Schwandt, Joern; Stadie, Hartmut; Steinbrück, Georg; Stober, Fred-Markus Helmut; Stöver, Marc; Tholen, Heiner; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Vanhoefer, Annika; Vormwald, Benedikt; Akbiyik, Melike; Barth, Christian; Baur, Sebastian; Baus, Colin; Berger, Joram; Butz, Erik; Caspart, René; Chwalek, Thorsten; Colombo, Fabio; De Boer, Wim; Dierlamm, Alexander; Fink, Simon; Freund, Benedikt; Friese, Raphael; Giffels, Manuel; Gilbert, Andrew; Goldenzweig, Pablo; Haitz, Dominik; Hartmann, Frank; Heindl, Stefan Michael; Husemann, Ulrich; Katkov, Igor; Kudella, Simon; Mildner, Hannes; Mozer, Matthias Ulrich; Müller, Thomas; Plagge, Michael; Quast, Gunter; Rabbertz, Klaus; Röcker, Steffen; Roscher, Frank; Schröder, Matthias; Shvetsov, Ivan; Sieber, Georg; Simonis, Hans-Jürgen; Ulrich, Ralf; Wayand, Stefan; Weber, Marc; Weiler, Thomas; Williamson, Shawn; Wöhrmann, Clemens; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Topsis-Giotis, Iasonas; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Tziaferi, Eirini; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Filipovic, Nicolas; Pasztor, Gabriella; Bencze, Gyorgy; Hajdu, Csaba; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Makovec, Alajos; Molnar, Jozsef; Szillasi, Zoltan; Bartók, Márton; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Komaragiri, Jyothsna Rani; Bahinipati, Seema; Bhowmik, Sandeep; Choudhury, Somnath; Mal, Prolay; Mandal, Koushik; Nayak, Aruna; Sahoo, Deepak Kumar; Sahoo, Niladribihari; Swain, Sanjay Kumar; Bansal, Sunil; Beri, Suman Bala; Bhatnagar, Vipin; Chawla, Ridhi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Anterpreet; Kaur, Manjit; Kumar, Ramandeep; Kumari, Priyanka; Mehta, Ankita; Mittal, Monika; Singh, Jasbir; Walia, Genius; Kumar, Ashok; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Garg, Rocky Bala; Keshri, Sumit; Malhotra, Shivali; Naimuddin, Md; Ranjan, Kirti; Sharma, Ramkrishna; Sharma, Varun; Bhattacharya, Rajarshi; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dey, Sourav; Dutt, Suneel; Dutta, Suchandra; Ghosh, Shamik; Majumdar, Nayana; Modak, Atanu; Mondal, Kuntal; Mukhopadhyay, Supratik; Nandan, Saswati; Purohit, Arnab; Roy, Ashim; Roy, Debarati; Roy Chowdhury, Suvankar; Sarkar, Subir; Sharan, Manoj; Thakur, Shalini; Behera, Prafulla Kumar; Chudasama, Ruchi; Dutta, Dipanwita; Jha, Vishwajeet; Kumar, Vineet; Mohanty, Ajit Kumar; Netrakanti, Pawan Kumar; Pant, Lalit Mohan; Shukla, Prashant; Topkar, Anita; Aziz, Tariq; Dugad, Shashikant; Kole, Gouranga; Mahakud, Bibhuprasad; Mitra, Soureek; Mohanty, Gagan Bihari; Parida, Bibhuti; Sur, Nairit; Sutar, Bajrang; Banerjee, Sudeshna; Dewanjee, Ram Krishna; Ganguly, Sanmay; Guchait, Monoranjan; Jain, Sandhya; Kumar, Sanjeev; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Sarkar, Tanmay; Wickramage, Nadeesha; Chauhan, Shubhanshu; Dube, Sourabh; Hegde, Vinay; Kapoor, Anshul; Kothekar, Kunal; Pandey, Shubham; Rane, Aditee; Sharma, Seema; Chenarani, Shirin; Eskandari Tadavani, Esmaeel; Etesami, Seyed Mohsen; Khakzad, Mohsen; Mohammadi Najafabadi, Mojtaba; Naseri, Mohsen; Paktinat Mehdiabadi, Saeid; Rezaei Hosseinabadi, Ferdos; Safarzadeh, Batool; Zeinali, Maryam; Felcini, Marta; Grunewald, Martin; Abbrescia, Marcello; Calabria, Cesare; Caputo, Claudio; Colaleo, Anna; Creanza, Donato; Cristella, Leonardo; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Maggi, Giorgio; Maggi, Marcello; Miniello, Giorgia; My, Salvatore; Nuzzo, Salvatore; Pompili, Alexis; Pugliese, Gabriella; Radogna, Raffaella; Ranieri, Antonio; Selvaggi, Giovanna; Sharma, Archana; Silvestris, Lucia; Venditti, Rosamaria; Verwilligen, Piet; Abbiendi, Giovanni; Battilana, Carlo; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Chhibra, Simranjit Singh; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Albergo, Sebastiano; Costa, Salvatore; Di Mattia, Alessandro; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Russo, Lorenzo; Sguazzoni, Giacomo; Strom, Derek; Viliani, Lorenzo; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Primavera, Federica; Calvelli, Valerio; Ferro, Fabrizio; Monge, Maria Roberta; Robutti, Enrico; Tosi, Silvano; Brianza, Luca; Brivio, Francesco; Ciriolo, Vincenzo; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Ghezzi, Alessio; Govoni, Pietro; Malberti, Martina; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Pigazzini, Simone; Ragazzi, Stefano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; De Nardo, Guglielmo; Di Guida, Salvatore; Esposito, Marco; Fabozzi, Francesco; Fienga, Francesco; Iorio, Alberto Orso Maria; Lanza, Giuseppe; Lista, Luca; Meola, Sabino; Paolucci, Pierluigi; Sciacca, Crisostomo; Thyssen, Filip; Azzi, Patrizia; Bacchetta, Nicola; Benato, Lisa; Bisello, Dario; Boletti, Alessio; Carlin, Roberto; Carvalho Antunes De Oliveira, Alexandra; Checchia, Paolo; Dall'Osso, Martino; De Castro Manzano, Pablo; Dorigo, Tommaso; Dosselli, Umberto; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Lacaprara, Stefano; Margoni, Martino; Meneguzzo, Anna Teresa; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Zanetti, Marco; Zotto, Pierluigi; Zumerle, Gianni; Braghieri, Alessandro; Fallavollita, Francesco; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Leonardi, Roberto; Mantovani, Giancarlo; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fedi, Giacomo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Cipriani, Marco; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Longo, Egidio; Margaroli, Fabrizio; Marzocchi, Badder; Meridiani, Paolo; Organtini, Giovanni; Paramatti, Riccardo; Preiato, Federico; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bartosik, Nazar; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Cenna, Francesca; Costa, Marco; Covarelli, Roberto; Degano, Alessandro; Demaria, Natale; Finco, Linda; Kiani, Bilal; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Monteil, Ennio; Monteno, Marco; Obertino, Maria Margherita; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Ravera, Fabio; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Shchelina, Ksenia; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Traczyk, Piotr; Belforte, Stefano; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; Zanetti, Anna; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Lee, Sangeun; Lee, Seh Wook; Oh, Young Do; Sekmen, Sezen; Son, Dong-Chul; Yang, Yu Chul; Lee, Ari; Kim, Hyunchul; Brochero Cifuentes, Javier Andres; Kim, Tae Jeong; Cho, Sungwoong; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Ha, Seungkyu; Hong, Byung-Sik; Jo, Youngkwon; Kim, Yongsun; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Lim, Jaehoon; Park, Sung Keun; Roh, Youn; Almond, John; Kim, Junho; Lee, Haneol; Oh, Sung Bin; Radburn-Smith, Benjamin Charles; Seo, Seon-hee; Yang, Unki; Yoo, Hwi Dong; Yu, Geum Bong; Choi, Minkyoo; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Goh, Junghwan; Hwang, Chanwook; Lee, Jongseok; Yu, Intae; Dudenas, Vytautas; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Zolkapli, Zukhaimira; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Mejia Guisao, Jhovanny; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Oropeza Barrera, Cristina; Vazquez Valencia, Fabiola; Carpinteyro, Severiano; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Saddique, Asif; Shah, Mehar Ali; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Calpas, Betty; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Voytishin, Nikolay; Zarubin, Anatoli; Chtchipounov, Leonid; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Murzin, Victor; Oreshkin, Vadim; Sulimov, Valentin; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Aushev, Tagir; Bylinkin, Alexander; Chistov, Ruslan; Polikarpov, Sergey; Zhemchugov, Evgenii; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Terkulov, Adel; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Bunichev, Viacheslav; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Klyukhin, Vyacheslav; Korneeva, Natalia; Lokhtin, Igor; Miagkov, Igor; Obraztsov, Stepan; Perfilov, Maxim; Savrin, Viktor; Volkov, Petr; Blinov, Vladimir; Skovpen, Yuri; Shtol, Dmitry; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Elumakhov, Dmitry; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Cirkovic, Predrag; Devetak, Damir; Dordevic, Milos; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Barrio Luna, Mar; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Senghi Soares, Mara; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Gonzalez Caballero, Isidro; González Fernández, Juan Rodrigo; Palencia Cortezon, Enrique; Sanchez Cruz, Sergio; Suárez Andrés, Ignacio; Vischia, Pietro; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Curras, Esteban; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Martinez Rivero, Celso; Matorras, Francisco; Piedra Gomez, Jonatan; Rodrigo, Teresa; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Trevisani, Nicolò; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Baillon, Paul; Ball, Austin; Barney, David; Bloch, Philippe; Bocci, Andrea; Botta, Cristina; Camporesi, Tiziano; Castello, Roberto; Cepeda, Maria; Cerminara, Gianluca; Chen, Yi; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Roeck, Albert; Di Marco, Emanuele; Dobson, Marc; Dorney, Brian; Du Pree, Tristan; Duggan, Daniel; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Everaerts, Pieter; Fartoukh, Stephane; Franzoni, Giovanni; Fulcher, Jonathan; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Girone, Maria; Glege, Frank; Gulhan, Doga; Gundacker, Stefan; Guthoff, Moritz; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kieseler, Jan; Kirschenmann, Henning; Knünz, Valentin; Kornmayer, Andreas; Kortelainen, Matti J; Kousouris, Konstantinos; Krammer, Manfred; Lange, Clemens; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Meijers, Frans; Merlin, Jeremie Alexandre; Mersi, Stefano; Meschi, Emilio; Milenovic, Predrag; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuel; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Racz, Attila; Reis, Thomas; Rolandi, Gigi; Rovere, Marco; Sakulin, Hannes; Sauvan, Jean-Baptiste; Schäfer, Christoph; Schwick, Christoph; Seidel, Markus; Sharma, Archana; Silva, Pedro; Sphicas, Paraskevas; Steggemann, Jan; Stoye, Markus; Takahashi, Yuta; Tosi, Mia; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veckalns, Viesturs; Veres, Gabor Istvan; Verweij, Marta; Wardle, Nicholas; Wöhri, Hermine Katharina; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Rohe, Tilman; Wiederkehr, Stephan Albert; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Casal, Bruno; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Grab, Christoph; Heidegger, Constantin; Hits, Dmitry; Hoss, Jan; Kasieczka, Gregor; Lustermann, Werner; Mangano, Boris; Marionneau, Matthieu; Martinez Ruiz del Arbol, Pablo; Masciovecchio, Mario; Meinhard, Maren Tabea; Meister, Daniel; Micheli, Francesco; Musella, Pasquale; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pata, Joosep; Pauss, Felicitas; Perrin, Gaël; Perrozzi, Luca; Quittnat, Milena; Rossini, Marco; Schönenberger, Myriam; Starodumov, Andrei; Tavolaro, Vittorio Raoul; Theofilatos, Konstantinos; Wallny, Rainer; Aarrestad, Thea Klaeboe; Amsler, Claude; Caminada, Lea; Canelli, Maria Florencia; De Cosa, Annapaola; Galloni, Camilla; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Ngadiuba, Jennifer; Pinna, Deborah; Rauco, Giorgia; Robmann, Peter; Salerno, Daniel; Seitz, Claudia; Yang, Yong; Zucchetta, Alberto; Candelise, Vieri; Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Pozdnyakov, Andrey; Yu, Shin-Shan; Kumar, Arun; Chang, Paoti; Chang, You-Hao; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Fiori, Francesco; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Paganis, Efstathios; Psallidas, Andreas; Tsai, Jui-fa; Asavapibhop, Burin; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Adiguzel, Aytul; Bakirci, Mustafa Numan; Damarseckin, Serdal; Demiroglu, Zuhal Seyma; Dozen, Candan; Eskut, Eda; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Hos, Ilknur; Kangal, Evrim Ersin; Kara, Ozgun; Kiminsu, Ugur; Oglakci, Mehmet; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Polatoz, Ayse; Sunar Cerci, Deniz; Turkcapar, Semra; Zorbakir, Ibrahim Soner; Zorbilmez, Caglar; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; Gülmez, Erhan; Kaya, Mithat; Kaya, Ozlem; Yetkin, Elif Asli; Yetkin, Taylan; Cakir, Altan; Cankocak, Kerem; Sen, Sercan; Grynyov, Boris; Levchuk, Leonid; Sorokin, Pavel; Aggleton, Robin; Ball, Fionn; Beck, Lana; Brooke, James John; Burns, Douglas; Clement, Emyr; Cussans, David; Flacher, Henning; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Sakuma, Tai; Seif El Nasr-storey, Sarah; Smith, Dominic; Smith, Vincent J; Bell, Ken W; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Calligaris, Luigi; Cieri, Davide; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Tomalin, Ian R; Williams, Thomas; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Bundock, Aaron; Burton, Darren; Casasso, Stefano; Citron, Matthew; Colling, David; Corpe, Louie; Dauncey, Paul; Davies, Gavin; De Wit, Adinda; Della Negra, Michel; Di Maria, Riccardo; Dunne, Patrick; Elwood, Adam; Futyan, David; Haddad, Yacine; Hall, Geoffrey; Iles, Gregory; James, Thomas; Lane, Rebecca; Laner, Christian; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Mastrolorenzo, Luca; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Penning, Bjoern; Pesaresi, Mark; Raymond, David Mark; Richards, Alexander; Rose, Andrew; Scott, Edward; Seez, Christopher; Summers, Sioni; Tapper, Alexander; Uchida, Kirika; Vazquez Acosta, Monica; Virdee, Tejinder; Wright, Jack; Zenz, Seth Conrad; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Borzou, Ahmad; Call, Kenneth; Dittmann, Jay; Hatakeyama, Kenichi; Liu, Hongxuan; Pastika, Nathaniel; Bartek, Rachel; Dominguez, Aaron; Buccilli, Andrew; Cooper, Seth; Henderson, Conor; Rumerio, Paolo; West, Christopher; Arcaro, Daniel; Avetisyan, Aram; Bose, Tulika; Gastler, Daniel; Rankin, Dylan; Richardson, Clint; Rohlf, James; Sulak, Lawrence; Zou, David; Benelli, Gabriele; Cutts, David; Garabedian, Alex; Hakala, John; Heintz, Ulrich; Hogan, Julie Managan; Jesus, Orduna; Kwok, Ka Hei Martin; Laird, Edward; Landsberg, Greg; Mao, Zaixing; Narain, Meenakshi; Piperov, Stefan; Sagir, Sinan; Spencer, Eric; Syarif, Rizki; Breedon, Richard; Burns, Dustin; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Flores, Chad; Funk, Garrett; Gardner, Michael; Ko, Winston; Lander, Richard; Mclean, Christine; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Shalhout, Shalhout; Shi, Mengyao; Smith, John; Squires, Michael; Stolp, Dustin; Tos, Kyle; Tripathi, Mani; Bachtis, Michail; Bravo, Cameron; Cousins, Robert; Dasgupta, Abhigyan; Florent, Alice; Hauser, Jay; Ignatenko, Mikhail; Mccoll, Nickolas; Saltzberg, David; Schnaible, Christian; Valuev, Vyacheslav; Weber, Matthias; Bouvier, Elvire; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Ghiasi Shirazi, Seyyed Mohammad Amin; Hanson, Gail; Heilman, Jesse; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Long, Owen Rosser; Olmedo Negrete, Manuel; Paneva, Mirena Ivova; Shrinivas, Amithabh; Si, Weinan; Wei, Hua; Wimpenny, Stephen; Yates, Brent; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; Derdzinski, Mark; Gerosa, Raffaele; Holzner, André; Klein, Daniel; Krutelyov, Vyacheslav; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Wood, John; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Amin, Nick; Bhandari, Rohan; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Franco Sevilla, Manuel; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Heller, Ryan; Incandela, Joe; Mullin, Sam Daniel; Ovcharova, Ana; Qu, Huilin; Richman, Jeffrey; Stuart, David; Suarez, Indara; Yoo, Jaehyeok; Anderson, Dustin; Bendavid, Joshua; Bornheim, Adolf; Bunn, Julian; Duarte, Javier; Lawhorn, Jay Mathew; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Spiropulu, Maria; Vlimant, Jean-Roch; Xie, Si; Zhu, Ren-Yuan; Andrews, Michael Benjamin; Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Weinberg, Marc; Cumalat, John Perry; Ford, William T; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Leontsinis, Stefanos; Mulholland, Troy; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Mcdermott, Kevin; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Tan, Shao Min; Tao, Zhengcheng; Thom, Julia; Tucker, Jordan; Wittich, Peter; Zientek, Margaret; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Apollinari, Giorgio; Apresyan, Artur; Banerjee, Sunanda; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cremonesi, Matteo; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hare, Daryl; Harris, Robert M; Hasegawa, Satoshi; Hirschauer, James; Hu, Zhen; Jayatilaka, Bodhitha; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Klima, Boaz; Kreis, Benjamin; Lammel, Stephan; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Miaoyuan; Liu, Tiehui; Lopes De Sá, Rafael; Lykken, Joseph; Maeshima, Kaori; Magini, Nicolo; Marraffino, John Michael; Maruyama, Sho; Mason, David; McBride, Patricia; Merkel, Petra; Mrenna, Stephen; Nahn, Steve; O'Dell, Vivian; Pedro, Kevin; Prokofyev, Oleg; Rakness, Gregory; Ristori, Luciano; Sexton-Kennedy, Elizabeth; Soha, Aron; Spalding, William J; Spiegel, Leonard; Stoynev, Stoyan; Strait, James; Strobbe, Nadja; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vernieri, Caterina; Verzocchi, Marco; Vidal, Richard; Wang, Michael; Weber, Hannsjoerg Artur; Whitbeck, Andrew; Wu, Yujun; Acosta, Darin; Avery, Paul; Bortignon, Pierluigi; Bourilkov, Dimitri; Brinkerhoff, Andrew; Carnes, Andrew; Carver, Matthew; Curry, David; Das, Souvik; Field, Richard D; Furic, Ivan-Kresimir; Konigsberg, Jacobo; Korytov, Andrey; Low, Jia Fu; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Mitselmakher, Guenakh; Rank, Douglas; Shchutska, Lesya; Sperka, David; Thomas, Laurent; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Todd; Askew, Andrew; Bein, Samuel; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Kolberg, Ted; Prosper, Harrison; Santra, Arka; Yohay, Rachel; Baarmand, Marc M; Bhopatkar, Vallary; Colafranceschi, Stefano; Hohlmann, Marcus; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Jung, Kurt; Sandoval Gonzalez, Irving Daniel; Varelas, Nikos; Wang, Hui; Wu, Zhenbin; Zakaria, Mohammed; Zhang, Jingyu; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tiras, Emrah; Wetzel, James; Yi, Kai; Blumenfeld, Barry; Cocoros, Alice; Eminizer, Nicholas; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Roskes, Jeffrey; Sarica, Ulascan; Swartz, Morris; Xiao, Meng; You, Can; Al-bataineh, Ayman; Baringer, Philip; Bean, Alice; Boren, Samuel; Bowen, James; Castle, James; Forthomme, Laurent; Kenny III, Raymond Patrick; Khalil, Sadia; Kropivnitskaya, Anna; Majumder, Devdatta; Mcbrayer, William; Murray, Michael; Sanders, Stephen; Stringer, Robert; Tapia Takaki, Daniel; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Gomez, Jaime; Hadley, Nicholas John; Jabeen, Shabnam; Jeng, Geng-Yuan; Kellogg, Richard G; Kunkle, Joshua; Mignerey, Alice; Ricci-Tam, Francesca; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Abercrombie, Daniel; Allen, Brandon; Apyan, Aram; Azzolini, Virginia; Barbieri, Richard; Baty, Austin; Bi, Ran; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; D'Alfonso, Mariarosaria; Demiragli, Zeynep; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Hsu, Dylan; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Krajczar, Krisztian; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Maier, Benedikt; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Narayanan, Siddharth; Niu, Xinmei; Paus, Christoph; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Tatar, Kaya; Velicanu, Dragos; Wang, Jing; Wang, Ta-Wei; Wyslouch, Bolek; Benvenuti, Alberto; Chatterjee, Rajdeep Mohan; Evans, Andrew; Hansen, Peter; Kalafut, Sean; Kao, Shih-Chuan; Kubota, Yuichi; Lesko, Zachary; Mans, Jeremy; Nourbakhsh, Shervin; Ruckstuhl, Nicole; Rusack, Roger; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bloom, Kenneth; Claes, Daniel R; Fangmeier, Caleb; Gonzalez Suarez, Rebeca; Kamalieddin, Rami; Kravchenko, Ilya; Malta Rodrigues, Alan; Monroy, Jose; Siado, Joaquin Emilo; Snow, Gregory R; Stieger, Benjamin; Alyari, Maral; Dolen, James; Godshalk, Andrew; Harrington, Charles; Iashvili, Ia; Kaisen, Josh; Nguyen, Duong; Parker, Ashley; Rappoccio, Salvatore; Roozbahani, Bahareh; Alverson, George; Barberis, Emanuela; Hortiangtham, Apichart; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Teixeira De Lima, Rafael; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Bhattacharya, Saptaparna; Charaf, Otman; Hahn, Kristan Allan; Kumar, Ajay; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Schmitt, Michael Henry; Sung, Kevin; Trovato, Marco; Velasco, Mayda; Dev, Nabarun; Hildreth, Michael; Hurtado Anampa, Kenyi; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Marinelli, Nancy; Meng, Fanbo; Mueller, Charles; Musienko, Yuri; Planer, Michael; Reinsvold, Allison; Ruchti, Randy; Rupprecht, Nathaniel; Smith, Geoffrey; Taroni, Silvia; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Alimena, Juliette; Antonelli, Louis; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Francis, Brian; Hart, Andrew; Hill, Christopher; Hughes, Richard; Ji, Weifeng; Liu, Bingxuan; Luo, Wuming; Puigh, Darren; Winer, Brian L; Wulsin, Howard Wells; Cooperstein, Stephane; Driga, Olga; Elmer, Peter; Hardenbrook, Joshua; Hebda, Philip; Lange, David; Luo, Jingyu; Marlow, Daniel; Medvedeva, Tatiana; Mei, Kelvin; Ojalvo, Isabel; Olsen, James; Palmer, Christopher; Piroué, Pierre; Stickland, David; Svyatkovskiy, Alexey; Tully, Christopher; Malik, Sudhir; Barker, Anthony; Barnes, Virgil E; Folgueras, Santiago; Gutay, Laszlo; Jha, Manoj; Jones, Matthew; Jung, Andreas Werner; Khatiwada, Ajeeta; Miller, David Harry; Neumeister, Norbert; Schulte, Jan-Frederik; Shi, Xin; Sun, Jian; Wang, Fuqiang; Xie, Wei; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Chen, Zhenyu; Ecklund, Karl Matthew; Geurts, Frank JM; Guilbaud, Maxime; Li, Wei; Michlin, Benjamin; Northup, Michael; Padley, Brian Paul; Roberts, Jay; Rorie, Jamal; Tu, Zhoudunming; Zabel, James; Betchart, Burton; Bodek, Arie; de Barbaro, Pawel; Demina, Regina; Duh, Yi-ting; Ferbel, Thomas; Galanti, Mario; Garcia-Bellido, Aran; Han, Jiyeon; Hindrichs, Otto; Khukhunaishvili, Aleko; Lo, Kin Ho; Tan, Ping; Verzetti, Mauro; Agapitos, Antonis; Chou, John Paul; Gershtein, Yuri; Gómez Espinosa, Tirso Alejandro; Halkiadakis, Eva; Heindl, Maximilian; Hughes, Elliot; Kaplan, Steven; Kunnawalkam Elayavalli, Raghav; Kyriacou, Savvas; Lath, Amitabh; Nash, Kevin; Osherson, Marc; Saka, Halil; Salur, Sevil; Schnetzer, Steve; Sheffield, David; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Delannoy, Andrés G; Foerster, Mark; Heideman, Joseph; Riley, Grant; Rose, Keith; Spanier, Stefan; Thapa, Krishna; Bouhali, Othmane; Celik, Ali; Dalchenko, Mykhailo; De Mattia, Marco; Delgado, Andrea; Dildick, Sven; Eusebi, Ricardo; Gilmore, Jason; Huang, Tao; Juska, Evaldas; Kamon, Teruki; Mueller, Ryan; Pakhotin, Yuriy; Patel, Rishi; Perloff, Alexx; Perniè, Luca; Rathjens, Denis; Safonov, Alexei; Tatarinov, Aysen; Ulmer, Keith; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; De Guio, Federico; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Gurpinar, Emine; Kunori, Shuichi; Lamichhane, Kamal; Lee, Sung Won; Libeiro, Terence; Peltola, Timo; Undleeb, Sonaina; Volobouev, Igor; Wang, Zhixing; Greene, Senta; Gurrola, Alfredo; Janjam, Ravi; Johns, Willard; Maguire, Charles; Melo, Andrew; Ni, Hong; Sheldon, Paul; Tuo, Shengquan; Velkovska, Julia; Xu, Qiao; Arenton, Michael Wayne; Barria, Patrizia; Cox, Bradley; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Neu, Christopher; Sinthuprasith, Tutanon; Sun, Xin; Wang, Yanchu; Wolfe, Evan; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Sturdy, Jared; Belknap, Donald; Buchanan, James; Caillol, Cécile; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Gomber, Bhawna; Grothe, Monika; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Perry, Thomas; Pierro, Giuseppe Antonio; Polese, Giovanni; Ruggles, Tyler; Savin, Alexander; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel

2017-07-14

The first measurement of the jet mass $m_{\\text{jet}}$ of top quark jets produced in $\\mathrm{ t \\bar{t} }$ events from pp collisions at $\\sqrt{s}=$ 8 TeV is reported for the jet with the largest transverse momentum $p_{\\mathrm{T}}$ in highly boosted hadronic top quark decays. The data sample, collected with the CMS detector, corresponds to an integrated luminosity of 19.7 fb$^{-1}$. The measurement is performed in the lepton+jets channel in which the products of the semileptonic decay $\\mathrm{ t } \\to \\mathrm{ b }\\mathrm{ W }$ with $\\mathrm{ W }\\to\\ell \

Elevated Expression of GlpT and UhpT via FNR Activation Contributes to Increased Fosfomycin Susceptibility in Escherichia coli under Anaerobic Conditions

Science.gov (United States)

Kurabayashi, Kumiko; Tanimoto, Koichi; Fueki, Shinobu; Tomita, Haruyoshi

2015-01-01

Because a shortage of new antimicrobial agents is a critical issue at present, and with the spread of multidrug-resistant (MDR) pathogens, the use of fosfomycin to treat infections is being revisited as a “last-resort option.” This drug offers a particular benefit in that it is more effective against bacteria growing under oxygen-limited conditions, unlike other commonly used antimicrobials, such as fluoroquinolones and aminoglycosides. In this study, we showed that Escherichia coli strains, including enterohemorrhagic E. coli (EHEC), were more susceptible to fosfomycin when grown anaerobically than when grown aerobically, and we investigated how the activity of this drug was enhanced during anaerobic growth of E. coli. Our quantitative PCR analysis and a transport assay showed that E. coli cells grown under anaerobic conditions had higher levels of expression of glpT and uhpT, encoding proteins that transport fosfomycin into cells with their native substrates, i.e., glycerol-3-phosphate and glucose-6-phosphate, and led to increased intracellular accumulation of the drug. Elevation of expression of these genes during anaerobic growth requires FNR, a global transcriptional regulator that is activated under anaerobic conditions. Purified FNR bound to DNA fragments from regions upstream of glpT and uhpT, suggesting that it is an activator of expression of glpT and uhpT during anaerobic growth. We concluded that the increased antibacterial activity of fosfomycin toward E. coli under anaerobic conditions can be attributed to elevated expression of GlpT and UhpT following activation of FNR, leading to increased uptake of the drug. PMID:26248376

Study of the conditions for spontaneous H-mode transitions in DIII-D

International Nuclear Information System (INIS)

Carlstrom, T.N.; Groebner, R.J.

1996-01-01

A series of scaling studies attempting to correlate the H(high)-mode power threshold (P TH ) with global parameters have been conducted. Data from these discharges is also being used to look for dependence of P TH on local edge parameters and to test theories of the transition. Boronization and better operational techniques have resulted in lower power thresholds and weaker density scaling. Neon impurity injection experiments show that radiation also plays a role in determining P TH . A low density threshold for the L(low)-H(high) transition has been linked with the locked mode low density limit, and can be reduced with the use of an error field correcting coil. Highly developed edge diagnostics, with spatial resolution as low as 5 mm, are used to evaluate how the power threshold depends on local edge conditions. Preliminary analysis of local edge conditions for parameter scans of n e , B T , and I p in single-null discharges, and the X-point imbalance in double-null discharges-show that, just before the transition to H-mode, the edge temperatures near the separatrix are approximately constant at 100 i e *i , varied from 2 to 17, demonstrating that a transition condition as simple as v *i = constant is inconsistent with the data. The local edge parameters of n e , T e , and T i do not always follow the same global scaling as P TH . Therefore, theories of the L-H transition need not be constrained by these scalings

Identification of candidates for postmastectomy radiotherapy in patients with pT3N0M0 breast cancer

International Nuclear Information System (INIS)

Hamamoto, Yasushi; Ohsumi, Shozo; Aogi, Kenjiro; Takashima, Shigemitsu; Shinohara, Shuichi; Nakajima, Naomi; Kataoka, Masaaki

2013-01-01

There is still controversy concerning the indication of postmastectomy radiotherapy (PMRT) for pT3N0M0 breast cancer. To identify the candidates for PMRT in this subset, we investigated failure patterns, and searched for risk factors for isolated locoregional failure in pT3N0M0 breast cancer after mastectomy without PMRT. Among 1,176 patients who received mastectomy without PMRT for untreated unilateral breast cancer between 1990 and 2002, 64 patients (5%) had pT3N0M0 breast cancer (age 30-81 years; median 52.5 years). Isolated locoregional failure as the initial failure occurred in three patients. For all 64 patients, the 8-year failure-free survival rate, the isolated locoregional failure-free rate, and the distant failure-free rate were 76, 93, and 82%, respectively. Incidence of isolated locoregional failure as the initial failure was 18% (2/11) for patients 40 years or younger and 2% (1/53) for patients older than 40 years. The 8-year isolated locoregional failure-free rates were 73% for patients 40 years or younger and 98% for patients older than 40 years (p=0.0135). Concerning pT3N0M0 breast cancer, incidence of isolated locoregional failure was comparatively low after mastectomy without PMRT. Routine use of PMRT for all pT3N0M0 patients seemed to be unacceptable. PMRT may be useful for younger patients because of the comparatively high incidence of isolated locoregional failure. Because of the small number of cases in our series, further studies are necessary to determine the usefulness of PMRT for younger patients with pT3N0M0 breast cancer. (author)

Initial test of a T9-like P300-based speller by an ALS patient

Science.gov (United States)

Ron-Angevin, R.; Varona-Moya, S.; da Silva-Sauer, L.

2015-08-01

Objective. Visual P300-based brain-computer interface spellers offer a useful communication channel for locked-in patients, who are completely dependent in their daily lives. One of the research goals for these systems is to achieve greater communication rates by means of modifying some features of their interfaces, e.g., reducing the matrix size. However, such modifications may not work well with disabled end-users, such as patients of amyotrophic lateral sclerosis (ALS), due to a supposed reduction of their cognitive resources. The purpose of the present study was to provide a proof of concept that ALS patients could efficiently use a P300-based speller with a 4 × 3 symbol matrix based on the T9 interface developed for mobile phones. Approach. We conducted an experiment with a sample of 11 able-bodied participants and one locked-in patient with ALS. All participants tested our T9-like visual P300-based speller and also two different 7 × 6 matrix spellers based on Farwell and Donchin’s classic proposal—one of them included a word predictor system like the T9-like speller did. Main results. The performance analyses indicated that the locked-in patient benefited from using a reduced matrix size as much as healthy users did, spelling words almost 1.6 times faster and equally accurately when using the T9-like speller than when using the alternative spellers. Significance. Due to counting on only one locked-in patient, the current work constitutes a feasibility study. The actual usability of systems such as the one proposed in this paper should be determined by means of studies with a greater number of end-users in real-life conditions.

Measurement of the nuclear modification factor for high-$p_\\mathrm{T}$ charged hadrons in pPb collisions with the ATLAS detector

CERN Document Server

Balek, Petr; The ATLAS collaboration

2016-01-01

The charged hadron spectra in p+Pb and pp collisions at $\\sqrt{s}=5.02$TeV are measured with the ATLAS experiment at the LHC. The measurements are performed with p+Pb data recorded in 2013 with an integrated luminosity of 25nb${}^{-1}$ and pp data recorded in 2015 with an integrated luminosity of 25pb${}^{-1}$. The p+Pb results are directly compared to pp spectra, as a ratio scaled by the number of binary nucleon-nucleon collisions, the nuclear modification factor $R\\mathrm{pPb}$. It allows for a detailed comparison of the collision systems in different centrality intervals and up to high transverse momentum.

The increase in T sub c for MgB sub 2 superconductor under high pressure

CERN Document Server

Liu, Z X; You, J Y; Li, S C; Zhu, J L; Yu, R C; Li, F Y; Su, S K

2002-01-01

We report in situ high-pressure studies up to 1.0 GPa on MgB sub 2 superconductor which had been synthesized at high pressure. The as-prepared sample is of high quality as regards having a sharp superconducting transition (T sub c) at 39 K. The in situ high-pressure measurements were carried out using a Be-Cu piston-cylinder-type instrument with a mixed oil as the pressure-transmitting medium, which provides a quasi-hydrostatic pressure environment at low temperature. The superconducting transitions were measured using the electrical conductance method. It is found that T sub c increases with pressure in the initial pressure range, leading to a parabolic-like T sub c -P evolution.

Plant uptake of phosphorus from sparingly available P- sources as affected by Trichoderma asperellum T34

Directory of Open Access Journals (Sweden)

Ana Maria Garcia-Lopez

2015-10-01

Full Text Available The contribution of Trichoderma asperellum T34 to the plant uptake of phosphorus (P from sparingly phytoavailable forms such as insoluble calcium (Ca phosphates and phytates was studied. Two experiments with cucumber (Cucumis sativus L. on siliceous sand were performed involving two factors, namely: (i P source, viz., KH2PO4, phytate (Ins6P, and phosphate rock (PR, and (ii inoculation with T34. Liquid pure cultures of T34 were also used. T34 increased the total content in P of cucumber roots irrespective of the particular P form and enhanced total P uptake by plants with P supplied as Ins6P or PR. The increased phytase activity observed with T34 contributes to explain its favourable influence on the uptake of P supplied as Ins6P. Solubilization of Ca phosphates from PR was favoured by the slightly acidifying effect and the increased organic anion concentration promoted by the fungus in the plant growth media. It can be concluded that T34 can improve P nutrition in plants grown on media containing phytates or insoluble Ca phosphates as dominant P forms.

Association of glutathione S-transferase (GSTM1, T1 and P1 gene polymorphisms with type 2 diabetes mellitus in north Indian population

Directory of Open Access Journals (Sweden)

Bid H

2010-01-01

Full Text Available Background: Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS and a reduction in antioxidant defense. The oxidative stress becomes evident as a result of accumulation of ROS in conditions of inflammation and Type 2 diabetes mellitus (T2DM. The genes involved in redox balance, which determines the susceptibility to T2DM remain unclear. In humans, the glutathione S-transferase (GST family comprises several classes of GST isozymes, the polymorphic variants of GSTM1, T1 and P1 genes result in decreased or loss of enzyme activity. Aims: The present study evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing T2DM in the North Indian population. Settings and Design: GSTM1, T1 and P1 polymorphisms were genotyped in 100 T2DM patients and 200 healthy controls from North India to analyze their association with T2DM susceptibility. Materials and Methods: Analysis of GSTM1 and GSTT1 gene polymorphisms was performed by multiplex polymerase chain reaction (PCR and GSTP1 by PCR-Restriction Fragment Length Polymorphism (RFLP. Statistical Analysis: Fisher′s exact test and χ2 statistics using SPSS software (Version-15.0. Results: We observed significant association of GSTM1 null (P=0.004, OR= 2.042, 95%CI= 1.254-3.325 and GSTP1 (I/V (P=0.001, OR= 0.397, 95%CI=0.225-0.701 with T2DM and no significant association with GSTT1 (P=0.493. The combined analysis of the three genotypes GSTM1 null, T1 present and P1 (I/I demonstrated an increase in T2DM risk (P= 0.005, OR= 2.431 95% CI=1.315-4.496. Conclusions: This is the first study showing the association of a combined effect of GSTM1, T1 and P1 genotypes in a representative cohort of Indian patients with T2DM. Since significant association was seen in GSTM1 null and GSTP1 (I/V and multiple association in GSTM1 null, T1 present and P1 (I/I, these polymorphisms can be screened in the population to determine the diabetic risk.

Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival

Directory of Open Access Journals (Sweden)

Silverman Lee

2007-07-01

Full Text Available Abstract Background Human T-lymphotropic virus type-1 (HTLV-1 causes adult T-cell leukemia/lymphoma and is linked to a number of lymphocyte-mediated disorders. HTLV-1 contains both regulatory and accessory genes in four pX open reading frames. pX ORF-II encodes two proteins, p13 and p30, whose roles are still being defined in the virus life cycle and in HTLV-1 virus-host cell interactions. Proviral clones of HTLV-1 with pX ORF-II mutations diminish the ability of the virus to maintain viral loads in vivo. p30 expressed exogenously differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein/p300 and while acting as a repressor of many genes including Tax, in part by blocking tax/rex RNA nuclear export, selectively enhances key gene pathways involved in T-cell signaling/activation. Results Herein, we analyzed the role of p30 in cell cycle regulation. Jurkat T-cells transduced with a p30 expressing lentivirus vector accumulated in the G2-M phase of cell cycle. We then analyzed key proteins involved in G2-M checkpoint activation. p30 expression in Jurkat T-cells resulted in an increase in phosphorylation at serine 216 of nuclear cell division cycle 25C (Cdc25C, had enhanced checkpoint kinase 1 (Chk1 serine 345 phosphorylation, reduced expression of polo-like kinase 1 (PLK1, diminished phosphorylation of PLK1 at tyrosine 210 and reduced phosphorylation of Cdc25C at serine 198. Finally, primary human lymphocyte derived cell lines immortalized by a HTLV-1 proviral clone defective in p30 expression were more susceptible to camptothecin induced apoptosis. Collectively these data are consistent with a cell survival role of p30 against genotoxic insults to HTLV-1 infected lymphocytes. Conclusion Collectively, our data are the first to indicate that HTLV-1 p30 expression results in activation of the G2-M cell cycle checkpoint, events that would promote early viral spread and T

Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

Science.gov (United States)

Arai, Yasuyuki; Choi, Uimook; Corsino, Cristina I; Koontz, Sherry M; Tajima, Masaki; Sweeney, Colin L; Black, Mary A; Feldman, Steven A; Dinauer, Mary C; Malech, Harry L

2018-05-02

We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. We developed a distinctly different approach using c-kit CAR-T cells. Initial studies demonstrated in vitro killing of hematopoietic stem cells by c-kit CAR-T cells but poor expansion in vivo and poor migration of CAR-T cells into BM. Pre-treatment of recipient mice with low-dose cyclophosphamide (125 mg/kg) together with CXCR4 transduction in the CAR-T cells enhanced trafficking to and expansion in BM (c-kit + population (9.0%-0.1%). Because congenic Thy1.1 CAR-T cells were used in the Thy1.2-recipient mice, anti-Thy1.1 antibody could be used to deplete CAR-T cells in vivo before donor BM transplant. This achieved 20%-40% multilineage engraftment. We applied this conditioning to achieve an average of 28% correction of chronic granulomatous disease mice by wild-type BM transplant. Our findings provide a proof of concept that c-kit CAR-T cells can achieve effective BM conditioning without chemo-/radiotherapy. Our work also demonstrates that co-expression of a trafficking receptor can enhance targeting of CAR-T cells to a designated tissue. Published by Elsevier Inc.

High pT Hadronic Top Quark Identification

CERN Document Server

Brooijmans, G

2008-01-01

At the LHC objects with masses at the electroweak scale will for the first time be produced with very large transverse momenta. In many cases, these objects decay hadronically, producing a set of collimated jets. This interesting new experimental phenomenology requires the development and tuning of new tools, since the usual reconstruction methods would simply reconstruct a single jet. This note describes the application of the YSplitter algorithm in conjunction with the jet mass to identify high transverse momentum top quarks decaying hadronically.

Characteristics of Syngas Auto-ignition at High Pressure and Low Temperature Conditions with Thermal Inhomogeneities

KAUST Repository

Pal, Pinaki; Mansfield, Andrew B.; Wooldridge, Margaret S.; Im, Hong G.

2015-01-01

Effects of thermal inhomogeneities on syngas auto-ignition at high-pressure low-temperature conditions, relevant to gas turbine operation, are investigated using detailed one-dimensional numerical simulations. Parametric tests are carried out for a range of thermodynamic conditions (T = 890-1100 K, P = 3-20 atm) and composition (Ф = 0.1, 0.5). Effects of global thermal gradients and localized thermal hot spots are studied. In the presence of a thermal gradient, the propagating reaction front transitions from spontaneous ignition to deflagration mode as the initial mean temperature decreases. The critical mean temperature separating the two distinct auto-ignition modes is computed using a predictive criterion and found to be consistent with front speed and Damkohler number analyses. The hot spot study reveals that compression heating of end-gas mixture by the propagating front is more pronounced at lower mean temperatures, significantly advancing the ignition delay. Moreover, the compression heating effect is dependent on the domain size.

Characteristics of Syngas Auto-ignition at High Pressure and Low Temperature Conditions with Thermal Inhomogeneities

KAUST Repository

Pal, Pinaki

2015-05-31

Effects of thermal inhomogeneities on syngas auto-ignition at high-pressure low-temperature conditions, relevant to gas turbine operation, are investigated using detailed one-dimensional numerical simulations. Parametric tests are carried out for a range of thermodynamic conditions (T = 890-1100 K, P = 3-20 atm) and composition (Ф = 0.1, 0.5). Effects of global thermal gradients and localized thermal hot spots are studied. In the presence of a thermal gradient, the propagating reaction front transitions from spontaneous ignition to deflagration mode as the initial mean temperature decreases. The critical mean temperature separating the two distinct auto-ignition modes is computed using a predictive criterion and found to be consistent with front speed and Damkohler number analyses. The hot spot study reveals that compression heating of end-gas mixture by the propagating front is more pronounced at lower mean temperatures, significantly advancing the ignition delay. Moreover, the compression heating effect is dependent on the domain size.

Is Real-World Evidence Used in P&T Monographs and Therapeutic Class Reviews?

Science.gov (United States)

Hurwitz, Jason T; Brown, Mary; Graff, Jennifer S; Peters, Loretta; Malone, Daniel C

2017-06-01

the United States (6), and funded by the pharmaceutical industry (5). GRACE Checklist ratings suggested the data and methods of these comparative RWE studies were of high quality. RWE was infrequently cited in P&T materials, even among therapeutic class reviews where RWE is more readily available. Although few P&T materials cited RWE, the comparative RWE studies were generally high quality. More research is needed to understand when and what types of real-world studies can more routinely inform coverage and reimbursement decisions. This project was funded by the National Pharmaceutical Council. Hurwitz, Brown, Peters, and Malone have nothing to disclose. Graff is employed by the National Pharmaceutical Council Part of this study was presented as a poster presentation at the AMCP Managed Care & Specialty Pharmacy 2016 Annual Meeting; April 19-22, 2016; San Francisco, CA. Study concept and design were primarily contributed by Malone and Graff, along with Hurwitz and Brown. All authors participated in data collection, and data interpretation was performed by Malone, Hurwitz, and Graff, with assistance from Brown and Peters. The manuscript was written primarily by Hurwitz and Malone, along with Graff, Brown, and Peters, and revised by Malone, Brown, Peters, Hurwitz, and Graff.

Enhanced D-T supershot performance at high current using extensive lithium conditioning in TFTR

International Nuclear Information System (INIS)

Mansfield, D.K.; Strachan, J.D.; Bell, M.G.; Scott, S.D.; Budny, R.; Bell, R.E.; Bitter, M.; Darrow, D.S.; Fredrickson, E.; Grek, B.

1995-05-01

A substantial improvement in supershot fusion plasma performance has been realized by combining the enhanced confinement due to tritium fueling with the enhanced confinement due to extensive Li conditioning of the TFTR limiter. This combination has resulted in not only significantly higher global energy confinement times than had previously been obtained in high current supershots, but also the highest ratio of central fusion output power to input power observed to date

Gene expression profiling upon 212Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model

International Nuclear Information System (INIS)

Yong, Kwon J; Milenic, Diane E; Baidoo, Kwamena E; Kim, Young-Seung; Brechbiel, Martin W

2013-01-01

Recent studies have demonstrated that therapy with 212 Pb-TCMC-trastuzumab resulted in (1) induction of apoptosis, (2) G2/M arrest, and (3) blockage of double-strand DNA damage repair in LS-174T i.p. (intraperitoneal) xenografts. To further understand the molecular basis of the cell killing efficacy of 212 Pb-TCMC-trastuzumab, gene expression profiling was performed with LS-174T xenografts 24 h after exposure to 212 Pb-TCMC-trastuzumab. DNA damage response genes (84) were screened using a quantitative real-time polymerase chain reaction array (qRT-PCR array). Differentially regulated genes were identified following exposure to 212 Pb-TCMC-trastuzumab. These included genes involved in apoptosis (ABL, GADD45α, GADD45γ, PCBP4, and p73), cell cycle (ATM, DDIT3, GADD45α, GTSE1, MKK6, PCBP4, and SESN1), and damaged DNA binding (DDB) and repair (ATM and BTG2). The stressful growth arrest conditions provoked by 212 Pb-TCMC-trastuzumab were found to induce genes involved in apoptosis and cell cycle arrest in the G2/M phase. The expression of genes involved in DDB and single-strand DNA breaks was also enhanced by 212 Pb-TCMC-trastuzumab while no modulation of genes involved in double-strand break repair was apparent. Furthermore, the p73/GADD45 signaling pathway mediated by p38 kinase signaling may be involved in the cellular response, as evidenced by the enhanced expression of genes and proteins of this pathway. These results further support the previously described cell killing mechanism by 212 Pb-TCMC-trastuzumab in the same LS-174T i.p. xenograft. Insight into these mechanisms could lead to improved strategies for rational application of radioimmunotherapy using α-particle emitters. The apoptotic response and associated gene modulations have not been clearly defined following exposure of cells to α-particle radioimmunotherapy (RIT). Gene expression profiling was performed with LS-174T i.p. (intraperitoneal) xenografts after exposure to 212 Pb

Protein Denaturation on p-T Axes--Thermodynamics and Analysis.

Science.gov (United States)

Smeller, László

2015-01-01

Proteins are essential players in the vast majority of molecular level life processes. Since their structure is in most cases substantial for their correct function, study of their structural changes attracted great interest in the past decades. The three dimensional structure of proteins is influenced by several factors including temperature, pH, presence of chaotropic and cosmotropic agents, or presence of denaturants. Although pressure is an equally important thermodynamic parameter as temperature, pressure studies are considerably less frequent in the literature, probably due to the technical difficulties associated to the pressure studies. Although the first steps in the high-pressure protein study have been done 100 years ago with Bridgman's ground breaking work, the field was silent until the modern spectroscopic techniques allowed the characterization of the protein structural changes, while the protein was under pressure. Recently a number of proteins were studied under pressure, and complete pressure-temperature phase diagrams were determined for several of them. This review summarizes the thermodynamic background of the typical elliptic p-T phase diagram, its limitations and the possible reasons for deviations of the experimental diagrams from the theoretical one. Finally we show some examples of experimentally determined pressure-temperature phase diagrams.

In situ developmental responses of tropical sea urchin larvae to ocean acidification conditions at naturally elevated pCO2 vent sites.

Science.gov (United States)

Lamare, Miles D; Liddy, Michelle; Uthicke, Sven

2016-11-30

Laboratory experiments suggest that calcifying developmental stages of marine invertebrates may be the most ocean acidification (OA)-sensitive life-history stage and represent a life-history bottleneck. To better extrapolate laboratory findings to future OA conditions, developmental responses in sea urchin embryos/larvae were compared under ecologically relevant in situ exposures on vent-elevated pCO 2 and ambient pCO 2 coral reefs in Papua New Guinea. Echinometra embryos/larvae were reared in meshed chambers moored in arrays on either venting reefs or adjacent non-vent reefs. After 24 and 48 h, larval development and morphology were quantified. Compared with controls (mean pH (T) = 7.89-7.92), larvae developing in elevated pCO 2 vent conditions (pH (T) = 7.50-7.72) displayed a significant reduction in size and increased abnormality, with a significant correlation of seawater pH with both larval size and larval asymmetry across all experiments. Reciprocal transplants (embryos from vent adults transplanted to control conditions, and vice versa) were also undertaken to identify if adult acclimatization can translate resilience to offspring (i.e. transgenerational processes). Embryos originating from vent adults were, however, no more tolerant to reduced pH. Sea temperature and chlorophyll-a concentrations (i.e. larval nutrition) did not contribute to difference in larval size, but abnormality was correlated with chlorophyll levels. This study is the first to examine the response of marine larvae to OA scenarios in the natural environment where, importantly, we found that stunted and abnormal development observed in situ are consistent with laboratory observations reported in sea urchins, in both the direction and magnitude of the response. © 2016 The Author(s).

Study on consumers’ attitudes towards Terms and Conditions (T&Cs) : final report

NARCIS (Netherlands)

Elshout, M.; Elsen, M.; Leenheer, J.; Loos, M.; Luzak, J.

2016-01-01

Previous research has shown that when buying products and services online, the vast majority of consumers accept Terms and Conditions (T&Cs) without even reading them. The current research examined effects of interventions aimed at making consumers aware of the quality of such T&Cs. This was done by

Oysters and eelgrass: potential partners in a high pCO2 ocean.

Science.gov (United States)

Groner, Maya L; Burge, Colleen A; Cox, Ruth; Rivlin, Natalie; Turner, Mo; Van Alstyne, Kathryn L; Wyllie-Echeverria, Sandy; Bucci, John; Staudigel, Philip; Friedman, Carolyn S

2018-05-25

Climate change is affecting the health and physiology of marine organisms and altering species interactions. Ocean acidification (OA) threatens calcifying organisms such as the Pacific oyster, Crassostrea gigas. In contrast, seagrasses, such as the eelgrass Zostera marina, can benefit from the increase in available carbon for photosynthesis found at a lower seawater pH. Seagrasses can remove dissolved inorganic carbon from OA environments, creating local daytime pH refugia. Pacific oysters may improve the health of eelgrass by filtering out pathogens such as Labyrinthula zosterae (LZ), which causes eelgrass wasting disease (EWD). We examined how co-culture of eelgrass ramets and juvenile oysters affected the health and growth of eelgrass and the mass of oysters under different pCO 2 exposures. In Phase I, each species was cultured alone or in co-culture at 12°C across ambient, medium, and high pCO 2 conditions, (656, 1158 and1606 μatm pCO 2 , respectively). Under high pCO 2 , eelgrass grew faster and had less severe EWD (contracted in the field prior to the experiment). Co-culture with oysters also reduced the severity of EWD. While the presence of eelgrass decreased daytime pCO 2 , this reduction was not substantial enough to ameliorate the negative impact of high pCO 2 on oyster mass. In Phase II, eelgrass alone or oysters and eelgrass in co-culture were held at 15°C under ambient and high pCO 2 conditions, (488 and 2013 μatm pCO 2 , respectively). Half of the replicates were challenged with cultured LZ. Concentrations of defensive compounds in eelgrass (total phenolics and tannins), were altered by LZ exposure and pCO 2 treatments. Greater pathogen loads and increased EWD severity were detected in LZ exposed eelgrass ramets; EWD severity was reduced at high relative to low pCO 2 . Oyster presence did not influence pathogen load or EWD severity; high LZ concentrations in experimental treatments may have masked the effect of this treatment. Collectively, these

105Ag and 107Ag with the (p, t) reaction

International Nuclear Information System (INIS)

Del Vecchio, R.M.; Oelrich, I.C.; Naumann, R.A.

1975-01-01

The 107 , 109 Ag(p, t) 105 , 107 Ag reactions have been studied at 30 MeV bombarding energy. Tritons were detected with a 60 cm position-sensitive wire proportional counter backed by a plastic scintillator in the focal plane of a quadrupole-dipole-dipole-dipole (QDDD) spectrograph. Multiplet structure, interpretable as the coupling of a 2p 1 / 2 proton to vibrational core states, was observed in both nuclei. In addition, some 50 levels in each nucleus were seen below about 3 MeV of excitation with a resolution of 10 keV. DWBA calculations with simple two particle configurations worked rather well and permitted the determination of L transfers. A considerable amount of (p, t) strength in the region from 2-3 MeV of excitation in each nucleus was observed, not all of which could be associated with expected weak coupling to the 3 - core state

Rapidity correlations between high pT intermediate vector bosons and jets in bar pp collisions at √s = 1.8 TeV

International Nuclear Information System (INIS)

Abachi, S.

1995-07-01

D OE has used W → eν and Z → e + e - events produced in association with a high p T , jet to examine the effects of strong radiative corrections. We have compared the primary jet pseudorapidity distribution, as a function of reconstructed W or Z boson rapidity to leading order (LO) and Next-to-Leading order (NLO) QCD Monte Carlo generators, as well as a model based on extended color dipoles. We find that the primary jet is more central than either LO or NLO expectations. None of the Monte Carlo programs does a good job of predicting the shape of the jet distributions as a function of intermediate vector bosons rapidity

Right-handed neutrinos and T-violating, P-conserving interactions

Directory of Open Access Journals (Sweden)

Basem Kamal El-Menoufi

2017-02-01

Full Text Available We show that experimental probes of the P-conserving, T-violating triple correlation in polarized neutron or nuclear β-decay provide a unique probe of possible T-violation at the TeV scale in the presence of right-handed neutrinos. In contrast to other possible sources of semileptonic T-violation involving only left-handed neutrinos, those involving right-handed neutrinos are relatively unconstrained by present limits on the permanent electric dipole moments of the electron, neutral atoms, and the neutron. On the other hand, LHC results for pp→e+ missing transverse energy imply that an order of magnitude of improvement in D-coefficient sensitivity would be needed for discovery. Finally, we discuss the interplay with the scale of neutrino mass and naturalness considerations.

P sub(T)-flow in 100 - 1000 TeV

International Nuclear Information System (INIS)

Amato, N.M.; Arata, N.; Maldonado, R.H.C.

1983-01-01

It is studied how the flow of transverse momenta (Σ P sub(T) or Σ ER) behaves in multi-particle production phenomena in the region of visible energy 10 -1000 TeV, using the emulsion chamber data of Brazil-Japan Collaboration. (Author) [pt

Can re-cTURBT be useful in pT1HG disease as a risk indicator of recurrence and progression? A single centre experience

Directory of Open Access Journals (Sweden)

Roberto Giulianelli

2017-12-01

Full Text Available Introduction: Understaging after initial transurethral resection is common in patients with high-risk non muscle infiltrating bladder cancer (NMIBC and can delay accurate diagnosis and definitive treatment. The rate of upstaging from T1 to T2 disease after repeated transurethral resection ranges from 0 to 28%, although the rate of upstaging may be even higher up to 49% when muscularis propria is absent in the first specimen. A restaging classic transurethral resection of bladder tumour (re-cTURBT is the better predictor of early stage progression. According to some reports, the rate of positivity for tumor in re-cTURBT performed within eight weeks after initial cTURBT was as high as 18-77%, and in about 40% of the patients a change in tumor stage was reported. We aimed to investigate, in high risk group, the presence of residual tumor following white light classical transurethral resection of bladder tumor (WLre-cTURBT and the different recurrence and progression rate between patients with persistent or negative (pT0 oncological disease after WLre-cTURBT. Materials and methods: A cohort of 285 patients presenting with primitive bladder cancer underwent to WLcTURBT from January 2011 to December 2015; out of them 92 (32.28% were T1HG. In according to EAU guidelines 2011, after 4-6 weeks all HG bladder cancer patients underwent a WL recTURBT . All patients were submitted to a subsequent followup including cystoscopy every 3 months with multiple biopsies, randomly and in the previous zone of resection; urinary citology on 3 specimens and kidney/bladder ultrasound every 6 months. The average follow-up was 48 months. Results: Following WLre-cTURBT we observed a persistent disease in 18 (15.2% patients: 14 (77.7% with a HG-NMIBC and 4 (22.2% with a high grade (HG muscle invasive bladder cancer (pT2HG. After follow up of all 92 patients according to the guidelines EAU, we observed recurrence in 36/92 (39.1% and progression in 14/92 (15.2%. Of 14 NMIBC

Elliptic hypergeometric integrals and 't Hooft anomaly matching conditions

Energy Technology Data Exchange (ETDEWEB)

Spiridonov, V.P. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Vartanov, G.S. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

2012-05-15

Elliptic hypergeometric integrals describe superconformal indices of 4d supersymmetric field theories. We show that all 't Hooft anomaly matching conditions for Seiberg dual theories can be derived from SL(3, Z)-modular transformation properties of the kernels of dual indices.

Enhanced T-odd, P-odd electromagnetic moments in reflection asymmetric nuclei

International Nuclear Information System (INIS)

Spevak, V.; Auerbach, N.; Flambaum, V.V.

1997-01-01

Collective P- and T-odd moments produced by parity and time invariance violating forces in reflection asymmetric nuclei are considered. The enhanced collective Schiff, electric dipole, and octupole moments appear due to the mixing of rotational levels of opposite parity. These moments can exceed single-particle moments by more than 2 orders of magnitude. The enhancement is due to the collective nature of the intrinsic moments and the small energy separation between members of parity doublets. In turn these nuclear moments induce enhanced T- and P-odd effects in atoms and molecules. A simple estimate is given and a detailed theoretical treatment of the collective T-, P-odd electric moments in reflection asymmetric, odd-mass nuclei is presented. In the present work we improve on the simple liquid drop model by evaluating the Strutinsky shell correction and include corrections due to pairing. Calculations are performed for octupole deformed long-lived odd-mass isotopes of Rn, Fr, Ra, Ac, and Pa and the corresponding atoms. Experiments with such atoms may improve substantially the limits on time reversal violation. copyright 1997 The American Physical Society

Large-scale Isolation of Highly Pure "Untouched" Regulatory T Cells in a GMP Environment for Adoptive Cell Therapy.

Science.gov (United States)

Haase, Doreen; Puan, Kia Joo; Starke, Mireille; Lai, Tuck Siong; Soh, Melissa Yan Ling; Karunanithi, Iyswariya; San Luis, Boris; Poh, Tuang Yeow; Yusof, Nurhashikin; Yeap, Chun Hsien; Phang, Chew Yen; Chye, Willis Soon Yuan; Chan, Marieta; Koh, Mickey Boon Chai; Goh, Yeow Tee; Bertin-Maghit, Sebastien; Nardin, Alessandra; Ho, Liam Pock; Rotzschke, Olaf

2015-01-01

Adoptive cell therapy is an emerging treatment strategy for a number of serious diseases. Regulatory T (Treg) cells represent 1 cell type of particular interest for therapy of inflammatory conditions, as they are responsible for controlling unwanted immune responses. Initial clinical trials of adoptive transfer of Treg cells in patients with graft-versus-host disease were shown to be safe. However, obtaining sufficient numbers of highly pure and functional Treg cells with minimal contamination remains a challenge. We developed a novel approach to isolate "untouched" human Treg cells from healthy donors on the basis of negative selection using the surface markers CD49d and CD127. This procedure, which uses an antibody cocktail and magnetic beads for separation in an automated system (RoboSep), was scaled up and adapted to be compatible with good manufacturing practice conditions. With this setup we performed 9 Treg isolations from large-scale leukapheresis samples in a good manufacturing practice facility. These runs yielded sufficient numbers of "untouched" Treg cells for immediate use in clinical applications. The cell preparations consisted of viable highly pure FoxP3-positive Treg cells that were functional in suppressing the proliferation of effector T cells. Contamination with CD4 effector T cells was cell types did not exceed 2% in the final product. Remaining isolation reagents were reduced to levels that are considered safe. Treg cells isolated with this procedure will be used in a phase I clinical trial of adoptive transfer into leukemia patients developing graft-versus-host disease after stem cell transplantation.

Microcyst response to high Dk/t silicone hydrogel contact lenses.

Science.gov (United States)

Keay, L; Sweeney, D F; Jalbert, I; Skotnitsky, C; Holden, B A

2000-11-01

To investigate the microcyst response to extended wear (EW) with high oxygen transmissible (Dk/t) silicone hydrogel lenses. Microcysts were monitored for 12 months in subjects wearing low Dk/t hydrogel lenses on a 6-night EW schedule or high Dk/t hydrogel lenses on a 30-night EW schedule. Subjects wearing low Dk/t lenses transferred to the high Dk/t EW lenses and schedule after 12 months and were monitored for a further 6 months. The mean number of microcysts did not deviate from baseline in the high Dk/t group. Microcysts in the low Dk/t group increased over 12 months, and more microcysts were observed in low Dk/t lens wearers compared with high Dk/t lens wearers after 3 months. Microcysts increased in 50% of subjects 1 week after transfer to high Dk/t lenses and returned to baseline levels seen with high Dk/t lens wear within 3 months. EW with high Dk/t silicone hydrogel lenses did not cause an increase in microcyst numbers. It is not necessary to discontinue lens wear with patients who transfer from low to high Dk/t lenses because the increase in microcysts is transitory. This result has implications for practitioners when fitting and assessing the success of high Dk/t hydrogel lenses.

J /ψ production at low pT in Au + Au and Cu + Cu collisions at √sNN =200 GeV with the STAR detector

Science.gov (United States)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Alford, J.; Anson, C. D.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Averichev, G. S.; Banerjee, A.; Beavis, D. R.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Borowski, W.; Bouchet, J.; Brandin, A. V.; Brovko, S. G.; Bültmann, S.; Bunzarov, I.; Burton, T. P.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Cendejas, R.; Cervantes, M. C.; Chaloupka, P.; Chang, Z.; Chattopadhyay, S.; Chen, H. F.; Chen, J. H.; Chen, L.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Chwastowski, J.; Codrington, M. J. M.; Contin, G.; Cramer, J. G.; Crawford, H. J.; Cui, X.; Das, S.; Davila Leyva, A.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; Derradi de Souza, R.; di Ruzza, B.; Didenko, L.; Dilks, C.; Ding, F.; Djawotho, P.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Engle, K. S.; Eppley, G.; Eun, L.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Fedorisin, J.; Filip, P.; Fisyak, Y.; Flores, C. E.; Gagliardi, C. A.; Gangadharan, D. R.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Gliske, S.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, A.; Gupta, S.; Guryn, W.; Haag, B.; Hamed, A.; Han, L.-X.; Haque, R.; Harris, J. W.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Hofman, D. J.; Horvat, S.; Huang, B.; Huang, H. Z.; Huang, X.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Kesich, A.; Khan, Z. H.; Kikola, D. P.; Kisel, I.; Kisiel, A.; Koetke, D. D.; Kollegger, T.; Konzer, J.; Koralt, I.; Kosarzewski, L. K.; Kotchenda, L.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kulakov, I.; Kumar, L.; Kycia, R. A.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, C.; Li, W.; Li, X.; Li, X.; Li, Y.; Li, Z. M.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, G. L.; Ma, Y. G.; Mahapatra, D. P.; Majka, R.; Margetis, S.; Markert, C.; Masui, H.; Matis, H. S.; McDonald, D.; McShane, T. S.; Minaev, N. G.; Mioduszewski, S.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nelson, J. M.; Nigmatkulov, G.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Ohlson, A.; Okorokov, V.; Oldag, E. W.; Olvitt, D. L.; Page, B. S.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlak, T.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Planinic, M.; Pluta, J.; Poljak, N.; Poniatowska, K.; Porter, J.; Poskanzer, A. M.; Powell, C. B.; Pruthi, N. K.; Przybycien, M.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, R.; Raniwala, S.; Ray, R. L.; Riley, C. K.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ross, J. F.; Roy, A.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sangaline, E.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, B.; Shen, W. Q.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Simko, M.; Skoby, M. J.; Smirnov, D.; Smirnov, N.; Solanki, D.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stevens, J. R.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Sun, X.; Sun, X. M.; Sun, Y.; Sun, Z.; Surrow, B.; Svirida, D. N.; Symons, T. J. M.; Szelezniak, M. A.; Takahashi, J.; Tang, A. H.; Tang, Z.; Tarnowsky, T.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Trzeciak, B. A.; Tsai, O. D.; Turnau, J.; Ullrich, T.; Underwood, D. G.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Vanfossen, J. A.; Varma, R.; Vasconcelos, G. M. S.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Viyogi, Y. P.; Vokal, S.; Vossen, A.; Wada, M.; Wang, F.; Wang, G.; Wang, H.; Wang, J. S.; Wang, X. L.; Wang, Y.; Wang, Y.; Webb, G.; Webb, J. C.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y. F.; Xiao, Z.; Xie, W.; Xin, K.; Xu, H.; Xu, J.; Xu, N.; Xu, Q. H.; Xu, Y.; Xu, Z.; Yan, W.; Yang, C.; Yang, Y.; Yang, Y.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, J. B.; Zhang, J. L.; Zhang, S.; Zhang, X. P.; Zhang, Y.; Zhang, Z. P.; Zhao, F.; Zhao, J.; Zhong, C.; Zhu, X.; Zhu, Y. H.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration

2014-08-01

The J /ψ pT spectrum and nuclear modification factor (RAA) are reported for pT<5GeV /c and |y|<1 from 0% to 60% central Au +Au and Cu +Cu collisions at √sNN =200GeV at STAR. A significant suppression of pT-integrated J /ψ production is observed in central Au +Au events. The Cu +Cu data are consistent with no suppression, although the precision is limited by the available statistics. RAA in Au +Au collisions exhibits a strong suppression at low transverse momentum and gradually increases with pT. The data are compared to high-pT STAR results and previously published BNL Relativistic Heavy Ion Collider results. Comparing with model calculations, it is found that the invariant yields at low pT are significantly above hydrodynamic flow predictions but are consistent with models that include color screening and regeneration.

A Muon Trigger with high pT-resolution for Phase-II of the LHC Upgrade, based on the ATLAS Muon Drift Tube Chambers

CERN Document Server

Nowak, S; The ATLAS collaboration

2014-01-01

The ATLAS Muon Trigger in the ATLAS end-cap region is based on Thin Gap Chambers (TGC) which have an excellent time resolution but a moderate spatial resolution. The Muon Trigger efficiency curves show that for a transverse momentum ($p_{t}$) threshold of 20 GeVc$^{-1}$ the trigger rate is mainly dominated by muons with a $p_{t}$ between 10 GeVc$^{-1}$ and 20 GeVc$^{-1}$. To cope with the expected Muon Trigger rate at HL-LHC luminosities, we propose to include the precision tracking chambers (MDT) in the Muon Trigger. According to a potential study based on ATLAS data and assuming the HL-LHC scenario, this leads to a dramatical reduction of the Muon Trigger rate below the nominal threshold. As the already existing MDT chamber read-out chain is not capable of reading out the MDT fast enough to be used for the Muon Trigger, an additional fast read-out (FRO) chain with moderate spatial resolution but low latency is necessary. To conduct fast track reconstruction and muon $p_{t}$ determination with the data acqui...

{sup 99m}Tc-N.T.P. 15-5 imaging for the early and specific diagnosis of chondrosarcoma: proof of concept in rats

Energy Technology Data Exchange (ETDEWEB)

Miot-Noirault, E.; Vidal, A.; Rapp, M.; Madelmont, J.C.; Maublant, J.; Moins, N. [Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 484, 63 - Clermont Ferrand (France); Redini, F.; Gouin, F.; Heymann, D. [Institut National de la Sante et de la Recherche Medicale (INSERM), ERI 7, EA 3822, 44 - Nantes (France)

2008-02-15

Aim. - The U.M.R. 484 I.N.S.E.R.M. develops a 'cartilage imaging strategy' with the {sup 99m}Tc-N.T.P. 15-5 tracer that selectively binds to cartilage proteoglycans, allowing a highly specific cartilage imaging. Since chondro-genic tumours are characterized by the presence of cartilaginous matrix, we hypothesized that the {sup 99m}Tc-N.T.P. 15-5 tracer would allow chondrosarcoma imaging, which is currently lacking in clinics. In the rat model of grade II para-tibial chondrosarcoma, we evaluated the relevance of {sup 99m}Tc-N.T.P. 15-5 imaging for an early and specific diagnosis of chondrosarcoma. Methods. - {sup 99m}Tc-N.T.P. 15-5 longitudinal imaging of animals was performed during two months after para-tibial ortho-topic tumour implantation in the right paw, the left being used as control. At regular intervals, animals were submitted to {sup 99m}Tc-M.D.P. bone imaging, the only examination used for SPECT diagnosis of chondrosarcoma in patients. Tumour volume was monitored for two months when the tumours became palpable, with the two perpendicular diameters measured. For both cartilage and bone imaging, the scans were considered positive when areas of tracer uptake were present at sites consistent with the sites of inoculation. For each animal, positive scans were analyzed at each stage using the semiquantitative method of the target to background ratio (T.B.R.), with the target R.O.I. being delineated over the tumour and background R.O.I. over vertebra and muscle. T.B.R. time-course was followed as a function of tumour growth.At study ending, each animal was sacrificed for histopathological control. Results. - {sup 99m}Tc-N.T.P. 15-5 scans were positive in 100% of the animals at very early stage (three days) after implantation, while no palpable nor measurable tumour could be assessed. Quantitative analysis of {sup 99m}Tc-N.T.P. 15-5 scans evidenced a significant uptake of the tracer at the implantation site at early stage. The time-course of T

KEAMANAN STEVIA HASIL BUDIDAYA B2P2TO2T DALAM ASPEK TERATOGENITAS

Directory of Open Access Journals (Sweden)

Lucie Widowati

2012-07-01

Full Text Available Teratogenic test has been performed on sweet stevia as product of B2P2TO2T cultivation at  rats (Rattus novergicus pregnant female  Wistar. Stevia sweet was administered orally at a dose of 360, 120 and 40 mg/kg bw, volume 1 ml/100g bw per day during organogenesis period, on the day of pregnancy to the 6th until 15th. During the test, test animals were observed two times daily with the distance of six hours against the toxicity symptoms such as changes in skin, hair, eyes and mucous membranes, bleeding. Animals that experienced abortion, premature birth or death during the trial period were sacrificed and observed immediately with microscopic technic. At 20th day of pregnancy all of the pregnant rat dissected, and put out the fetuses  from the mother's and observated the health conditions in general and  the whole of mothers reproductive systems of fetuses, the outer fetal malformation and soft tissue system of fetal. The conclusion were  sweet stevia  of B2P2TO2T  no worse effect on the mother rats, fetal body weight and morphology of mother rats and the fetus, does not affect the process of development of fetal soft tissue, and does not affect the development of fetal skeleton. Generally the B2P2TO2T stevia sweet substances safe for used, does not cause teratogenic effects.

Acetate biodegradation by anaerobic microorganisms at high pH and high calcium concentration

International Nuclear Information System (INIS)

Yoshida, Takahiro

2011-01-01

Acetate biodegradation at a high pH and a high calcium concentration was examined to clarify the effect of bacterial activity on the migration of organic 14 C compounds in cementitious repositories. Tamagawa river sediment or Teganuma pond sediment was anaerobically cultured with 5 mM acetate and 10 mM nitrate at pH 9.5-12 at 30 o C. After 20 and 90 days, the acetate concentration of the culture medium was analyzed and found to have decreased below 5 mM at pH ≤ 11. On the other hand, it did not decrease when either sediment was incubated in the absence of nitrate. These results suggest that nitrate-reducing bacteria can biodegrade acetate under more alkaline conditions than the reported pH range in which nitrate-reducing bacteria can exhibit activity. Acetate biodegradation was also examined at a high calcium concentration. Sediments were anaerobically cultured at pH 9.5 with 5 mM acetate and 10 mM nitrate in solution, equilibrated with ordinary Portland cement hydrate, in which the Ca concentration was 14.6 mM. No decrease in acetate concentration after incubation of the sediments was observed, nor was it lower than in the absence of cementitious composition, suggesting that kinetics of acetate biodegradation by anaerobic microorganisms is lowered by a high Ca concentration. - Research highlights: → Acetate biodegradation at a high pH and a high calcium concentration was examined to clarify the effect of bacterial activity on the migration of organic 14 C compounds in cementitious repositories. → Nitrate-reducing bacteria can biodegrade acetate at pH ≤ 11. → Kinetics of acetate biodegradation by anaerobic microorganisms might be lowered by a high Ca concentration.

Precipitation behavior and martensite lath coarsening during tempering of T/P92 ferritic heat-resistant steel

Science.gov (United States)

Xu, Lin-qing; Zhang, Dan-tian; Liu, Yong-chang; Ning, Bao-qun; Qiao, Zhi-xia; Yan, Ze-sheng; Li, Hui-jun

2014-05-01

Tempering is an important process for T/P92 ferritic heat-resistant steel from the viewpoint of microstructure control, as it facilitates the formation of final tempered martensite under serving conditions. In this study, we have gained deeper insights on the mechanism underlying the microstructural evolution during tempering treatment, including the precipitation of carbides and the coarsening of martensite laths, as systematically analyzed by optical microscopy, transmission electron microscopy, and high-resolution transmission electron microscopy. The chemical composition of the precipitates was analyzed using energy dispersive X-ray spectroscopy. Results indicate the formation of M3C (cementite) precipitates under normalized conditions. However, they tend to dissolve within a short time of tempering, owing to their low thermal stability. This phenomenon was substantiated by X-ray diffraction analysis. Besides, we could observe the precipitation of fine carbonitrides (MX) along the dislocations. The mechanism of carbon diffusion controlled growth of M23C6 can be expressed by the Zener's equation. The movement of Y-junctions was determined to be the fundamental mechanism underlying the martensite lath coarsening process. Vickers hardness was estimated to determine their mechanical properties. Based on the comprehensive analysis of both the micro-structural evolution and hardness variation, the process of tempering can be separated into three steps.

A requiem for AdS4×C P3 fermionic self-T duality

Science.gov (United States)

O'Colgáin, E.; Pittelli, A.

2016-11-01

Strong evidence for dual superconformal symmetry in N =6 superconformal Chern-Simons theory has fueled expectations that the AdS /CFT dual geometry AdS4×C P3 is self-dual under T duality. We revisit the problem to identify commuting bosonic and fermionic isometries in a systematic fashion and show that fermionic T duality, a symmetry originally proposed by Berkovits and Maldacena, inevitably leads to a singularity in the dilaton transformation. We show that TsT deformations commute with fermionic T duality and comment on T duality in the corresponding sigma model. Our results rule out self-duality based on fermionic T duality for AdS4×C P3 or its TsT deformations but leave the door open for new possibilities.

Design, conditioning, and performance of a high voltage, high brightness dc photoelectron gun with variable gap

Energy Technology Data Exchange (ETDEWEB)

Maxson, Jared; Bazarov, Ivan; Dunham, Bruce; Dobbins, John; Liu, Xianghong; Smolenski, Karl [Cornell Laboratory for Accelerator-Based Sciences and Education, Cornell University, Ithaca, New York 14853 (United States)

2014-09-15

A new high voltage photoemission gun has been constructed at Cornell University which features a segmented insulator and a movable anode, allowing the cathode-anode gap to be adjusted. In this work, we describe the gun's overall mechanical and high voltage design, the surface preparation of components, as well as the clean construction methods. We present high voltage conditioning data using a 50 mm cathode-anode gap, in which the conditioning voltage exceeds 500 kV, as well as at smaller gaps. Finally, we present simulated emittance results obtained from a genetic optimization scheme using voltage values based on the conditioning data. These results indicate that for charges up to 100 pC, a 30 mm gap at 400 kV has equal or smaller 100% emittance than a 50 mm gap at 450 kV, and also a smaller core emittance, when placed as the source for the Cornell energy recovery linac photoinjector with bunch length constrained to be <3 ps rms. For 100 pC up to 0.5 nC charges, the 50 mm gap has larger core emittance than the 30 mm gap, but conversely smaller 100% emittance.

Ductile fracture of two-phase welds under 77K. [Steel-EhP810, steel-EhP666, steel-08Kh18N10T, steel-EhP659-VI, steel-chP810

Energy Technology Data Exchange (ETDEWEB)

Yushchenko, K.A.; Voronin, S.A.; Pustovit, A.I.; Shavel' , A.V.

The effect of the type of welding and fillers on crack resistance of welded joints high-strength steel EhP810 and its various compounds with steels EhP666, 08Kh18N10T has been studied. For the welding of steel EhP810 with steels EhP810, EhP666, 08Kh18N10T electron-beam, automatic, argon tungsten arc with non-consumable electrode with various fillers, as well as argon metal-arc welding with consumable electrode, were used. It is shown, that for a joint, made by electron-beam welding, parameters sigmasub(u), Ksub(IcJ), KCV are higher than for a joint of a similar phase structure made using filler wire EhP659-VI. It is explained by the fact, that during electron-beam welding joint metal refining takes place, which removes gases. In welded joints of chP810 steel, having joints with austenitic structure, characteristic of crack resistance Ssub(c) increases by more than 0.2 mm in contrast to two-phase joints, which conventional yield strength at 77 K exceeds 1000 MPa. It is worth mentioning, that for other classes of steels formation of two-phase structure of joint increases welded joint resistance to brittle fracture. It is possible to obtain the required structure of joint with assigned level of resistance to brittle fracture by means of the use of different fillers, optimum and welding procedure, regulating the part of the basic metal in joint content.