WorldWideScience

Sample records for high mass accuracy

  1. High-accuracy mass spectrometry for fundamental studies.

    Science.gov (United States)

    Kluge, H-Jürgen

    2010-01-01

    Mass spectrometry for fundamental studies in metrology and atomic, nuclear and particle physics requires extreme sensitivity and efficiency as well as ultimate resolving power and accuracy. An overview will be given on the global status of high-accuracy mass spectrometry for fundamental physics and metrology. Three quite different examples of modern mass spectrometric experiments in physics are presented: (i) the retardation spectrometer KATRIN at the Forschungszentrum Karlsruhe, employing electrostatic filtering in combination with magnetic-adiabatic collimation-the biggest mass spectrometer for determining the smallest mass, i.e. the mass of the electron anti-neutrino, (ii) the Experimental Cooler-Storage Ring at GSI-a mass spectrometer of medium size, relative to other accelerators, for determining medium-heavy masses and (iii) the Penning trap facility, SHIPTRAP, at GSI-the smallest mass spectrometer for determining the heaviest masses, those of super-heavy elements. Finally, a short view into the future will address the GSI project HITRAP at GSI for fundamental studies with highly-charged ions.

  2. High-accuracy mass determination of unstable nuclei with a Penning trap mass spectrometer

    CERN Multimedia

    2002-01-01

    The mass of a nucleus is its most fundamental property. A systematic study of nuclear masses as a function of neutron and proton number allows the observation of collective and single-particle effects in nuclear structure. Accurate mass data are the most basic test of nuclear models and are essential for their improvement. This is especially important for the astrophysical study of nuclear synthesis. In order to achieve the required high accuracy, the mass of ions captured in a Penning trap is determined via their cyclotron frequency $ \

  3. High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

    NARCIS (Netherlands)

    Smith, D.F.; Kiss, A.; Leach, F.E.; Robinson, E.W.; Paša-Tolić, L.; Heeren, R.M.A.

    2013-01-01

    Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources. Endogenous lipids and other small bio-molecules can now be routinely mapped on the sub-micrometer scale. Such experiments are typically

  4. High Accuracy Mass Measurement of the Dripline Nuclides $^{12,14}$Be

    CERN Multimedia

    2002-01-01

    State-of-the art, three-body nuclear models that describe halo nuclides require the binding energy of the halo neutron(s) as a critical input parameter. In the case of $^{14}$Be, the uncertainty of this quantity is currently far too large (130 keV), inhibiting efforts at detailed theoretical description. A high accuracy, direct mass deterlnination of $^{14}$Be (as well as $^{12}$Be to obtain the two-neutron separation energy) is therefore required. The measurement can be performed with the MISTRAL spectrometer, which is presently the only possible solution due to required accuracy (10 keV) and short half-life (4.5 ms). Having achieved a 5 keV uncertainty for the mass of $^{11}$Li (8.6 ms), MISTRAL has proved the feasibility of such measurements. Since the current ISOLDE production rate of $^{14}$Be is only about 10/s, the installation of a beam cooler is underway in order to improve MISTRAL transmission. The projected improvement of an order of magnitude (in each transverse direction) will make this measureme...

  5. High Accuracy mass Measurement of the very Short-Lived Halo Nuclide $^{11}$Li

    CERN Multimedia

    Le scornet, G

    2002-01-01

    The archetypal halo nuclide $^{11}$Li has now attracted a wealth of experimental and theoretical attention. The most outstanding property of this nuclide, its extended radius that makes it as big as $^{48}$Ca, is highly dependent on the binding energy of the two neutrons forming the halo. New generation experiments using radioactive beams with elastic proton scattering, knock-out and transfer reactions, together with $\\textit{ab initio}$ calculations require the tightening of the constraint on the binding energy. Good metrology also requires confirmation of the sole existing precision result to guard against a possible systematic deviation (or mistake). We propose a high accuracy mass determintation of $^{11}$Li, a particularly challenging task due to its very short half-life of 8.6 ms, but one perfectly suiting the MISTRAL spectrometer, now commissioned at ISOLDE. We request 15 shifts of beam time.

  6. Analysis of the plasmodium falciparum proteome by high-accuracy mass spectrometry

    DEFF Research Database (Denmark)

    Lasonder, Edwin; Ishihama, Yasushi; Andersen, Jens S

    2002-01-01

    -accuracy (average deviation less than 0.02 Da at 1,000 Da) mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum. The analysis revealed 1,289 proteins of which 714 proteins were identified in asexual blood stages, 931 in gametocytes and 645 in gametes. The last...

  7. Neutrino mass from cosmology: impact of high-accuracy measurement of the Hubble constant

    Energy Technology Data Exchange (ETDEWEB)

    Sekiguchi, Toyokazu [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa 277-8582 (Japan); Ichikawa, Kazuhide [Department of Micro Engineering, Kyoto University, Kyoto 606-8501 (Japan); Takahashi, Tomo [Department of Physics, Saga University, Saga 840-8502 (Japan); Greenhill, Lincoln, E-mail: sekiguti@icrr.u-tokyo.ac.jp, E-mail: kazuhide@me.kyoto-u.ac.jp, E-mail: tomot@cc.saga-u.ac.jp, E-mail: greenhill@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2010-03-01

    Non-zero neutrino mass would affect the evolution of the Universe in observable ways, and a strong constraint on the mass can be achieved using combinations of cosmological data sets. We focus on the power spectrum of cosmic microwave background (CMB) anisotropies, the Hubble constant H{sub 0}, and the length scale for baryon acoustic oscillations (BAO) to investigate the constraint on the neutrino mass, m{sub ν}. We analyze data from multiple existing CMB studies (WMAP5, ACBAR, CBI, BOOMERANG, and QUAD), recent measurement of H{sub 0} (SHOES), with about two times lower uncertainty (5 %) than previous estimates, and recent treatments of BAO from the Sloan Digital Sky Survey (SDSS). We obtained an upper limit of m{sub ν} < 0.2eV (95 % C.L.), for a flat ΛCDM model. This is a 40 % reduction in the limit derived from previous H{sub 0} estimates and one-third lower than can be achieved with extant CMB and BAO data. We also analyze the impact of smaller uncertainty on measurements of H{sub 0} as may be anticipated in the near term, in combination with CMB data from the Planck mission, and BAO data from the SDSS/BOSS program. We demonstrate the possibility of a 5σ detection for a fiducial neutrino mass of 0.1 eV or a 95 % upper limit of 0.04 eV for a fiducial of m{sub ν} = 0 eV. These constraints are about 50 % better than those achieved without external constraint. We further investigate the impact on modeling where the dark-energy equation of state is constant but not necessarily -1, or where a non-flat universe is allowed. In these cases, the next-generation accuracies of Planck, BOSS, and 1 % measurement of H{sub 0} would all be required to obtain the limit m{sub ν} < 0.05−0.06 eV (95 % C.L.) for the fiducial of m{sub ν} = 0 eV. The independence of systematics argues for pursuit of both BAO and H{sub 0} measurements.

  8. High-accuracy mass measurements of neutron-rich Kr isotopes

    CERN Document Server

    Delahaye, P; Blaum, K; Carrel, F; George, S; Herfurth, F; Herlert, A; Kellerbauer, A G; Kluge, H J; Lunney, D; Schweikhard, L; Yazidjian, C

    2006-01-01

    The atomic masses of the neutron-rich krypton isotopes 84,86-95Kr have been determined with the tandem Penning trap mass spectrometer ISOLTRAP with uncertainties ranging from 20 to 220 ppb. The masses of the short-lived isotopes 94Kr and 95Kr were measured for the first time. The masses of the radioactive nuclides 89Kr and 91Kr disagree by 4 and 6 standard deviations, respectively, from the present Atomic-Mass Evaluation database. The resulting modification of the mass surface with respect to the two-neutron separation energies as well as implications for mass models and stellar nucleosynthesis are discussed.

  9. Accurate mass measurements of very short-lived nuclei. Prerequisites for high-accuracy investigations of superallowed β-decays

    International Nuclear Information System (INIS)

    Herfurth, F.; Kellerbauer, A.; Sauvan, E.; Ames, F.; Engels, O.; Audi, G.; Lunney, D.; Beck, D.; Blaum, K.; Kluge, H.J.; Scheidenberger, C.; Sikler, G.; Weber, C.; Bollen, G.; Schwarz, S.; Moore, R.B.; Oinonen, M.

    2002-01-01

    Mass measurements of 34 Ar, 73-78 Kr, and 74,76 Rb were performed with the Penning-trap mass spectrometer ISOLTRAP. Very accurate Q EC -values are needed for the investigations of the Ft-value of 0 + → 0 + nuclear β-decays used to test the standard model predictions for weak interactions. The necessary accuracy on the Q EC -value requires the mass of mother and daughter nuclei to be measured with δm/m ≤ 3 . 10 -8 . For most of the measured nuclides presented here this has been reached. The 34 Ar mass has been measured with a relative accuracy of 1.1 .10 -8 . The Q EC -value of the 34 Ar 0 + → 0 + decay can now be determined with an uncertainty of about 0.01%. Furthermore, 74 Rb is the shortest-lived nuclide ever investigated in a Penning trap. (orig.)

  10. Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry.

    Science.gov (United States)

    Görgens, Christian; Guddat, Sven; Thomas, Andreas; Wachsmuth, Philipp; Orlovius, Anne-Katrin; Sigmund, Gerd; Thevis, Mario; Schänzer, Wilhelm

    2016-11-30

    So far, in sports drug testing compounds of different classes are processed and measured using different screening procedures. The constantly increasing number of samples in doping analysis, as well as the large number of substances with doping related, pharmacological effects require the development of even more powerful assays than those already employed in sports drug testing, indispensably with reduced sample preparation procedures. The analysis of native urine samples after direct injection provides a promising analytical approach, which thereby possesses a broad applicability to many different compounds and their metabolites, without a time-consuming sample preparation. In this study, a novel multi-target approach based on liquid chromatography and high resolution/high accuracy mass spectrometry is presented to screen for more than 200 analytes of various classes of doping agents far below the required detection limits in sports drug testing. Here, classic groups of drugs as diuretics, stimulants, β 2 -agonists, narcotics and anabolic androgenic steroids as well as various newer target compounds like hypoxia-inducible factor (HIF) stabilizers, selective androgen receptor modulators (SARMs), selective estrogen receptor modulators (SERMs), plasma volume expanders and other doping related compounds, listed in the 2016 WADA prohibited list were implemented. As a main achievement, growth hormone releasing peptides could be implemented, which chemically belong to the group of small peptides (0.99), limit of detection (0.1-25ng/mL; 3'OH-stanozolol glucuronide: 50pg/mL; dextran/HES: 10μg/mL) and matrix effects. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Inkjet metrology: high-accuracy mass measurements of microdroplets produced by a drop-on-demand dispenser.

    Science.gov (United States)

    Verkouteren, R Michael; Verkouteren, Jennifer R

    2009-10-15

    We describe gravimetric methods for measuring the mass of droplets generated by a drop-on-demand (DOD) microdispenser. Droplets are deposited, either continuously at a known frequency or as a burst of known number, into a cylinder positioned on a submicrogram balance. Mass measurements are acquired precisely by computer, and results are corrected for evaporation. Capabilities are demonstrated using isobutyl alcohol droplets. For ejection rates greater than 100 Hz, the repeatability of droplet mass measurements was 0.2%, while the combined relative standard uncertainty (u(c)) was 0.9%. When bursts of droplets were dispensed, the limit of quantitation was 72 microg (1490 droplets) with u(c) = 1.0%. Individual droplet size in a burst was evaluated by high-speed videography. Diameters were consistent from the tenth droplet onward, and the mass of an individual droplet was best estimated by the average droplet mass with a combined uncertainty of about 1%. Diameters of the first several droplets were anomalous, but their contribution was accounted for when dispensing bursts. Above the limits of quantitation, the gravimetric methods provided statistically equivalent results and permit detailed study of operational factors that influence droplet mass during dispensing, including the development of reliable microassays and standard materials using DOD technologies.

  12. Study of the interaction of liquid with the surface of mass standards of high accuracy stainless steel

    International Nuclear Information System (INIS)

    Ramirez Varas, Lautaro; Castro, Claudio S.C.; Cacais, Fabio L.; Pires, Manoel J. M.; Loayza Mendoza, Victor M.

    2011-01-01

    The long term stability of mass standards depends on the interaction between the surface and environment molecules. From this point of view, a study was investigated of the effect on stainless steel surfaces by liquids frequently used in hydrostatic weighing (FC40) and in cleaning procedures of mass standards (isopropyl alcohol). Firstly, mass weighing difference was measured as function of time with a gravimetric method. Additionally, stainless steel samples were analyzed by X-ray Photoelectron Spectroscopy (XPS). The standard used for the gravimetric mass difference determination was immersed in FC40. The samples analyzed by XPS were previously immersed in both FC40 and isopropyl alcohol. Mass differences were obtained with an uncertainty of 1 μg when FC40 was used. Preliminary results have suggested that FC40 is not chemically bound to stainless steel surfaces and the mass gain was due to physisorbed molecules on the surface. (author) [es

  13. Accuracy of Combined Computed Tomography Colonography and Dual Energy Iiodine Map Imaging for Detecting Colorectal masses using High-pitch Dual-source CT.

    Science.gov (United States)

    Sun, Kai; Han, Ruijuan; Han, Yang; Shi, Xuesen; Hu, Jiang; Lu, Bin

    2018-02-28

    To evaluate the diagnostic accuracy of combined computed tomography colonography (CTC) and dual-energy iodine map imaging for detecting colorectal masses using high-pitch dual-source CT, compared with optical colonography (OC) and histopathologic findings. Twenty-eight consecutive patients were prospectively enrolled in this study. All patients were underwent contrast-enhanced CTC acquisition using dual-energy mode and OC and pathologic examination. The size of the space-occupied mass, the CT value after contrast enhancement, and the iodine value were measured and statistically compared. The sensitivity, specificity, accuracy rate, and positive predictive and negative predictive values of dual-energy contrast-enhanced CTC were calculated and compared between conventional CTC and dual-energy iodine images. The iodine value of stool was significantly lower than the colonic neoplasia (P dual-energy iodine maps imaging was 95.6% (95% CI = 77.9%-99.2%). The specificity of the two methods was 42.8% (95% CI = 15.4%-93.5%) and 100% (95% CI = 47.9%-100%; P = 0.02), respectively. Compared with optical colonography and histopathology, combined CTC and dual-energy iodine maps imaging can distinguish stool and colonic neoplasia, distinguish between benign and malignant tumors initially and improve the diagnostic accuracy of CTC for colorectal cancer screening.

  14. Mildronate (Meldonium) in professional sports - monitoring doping control urine samples using hydrophilic interaction liquid chromatography - high resolution/high accuracy mass spectrometry.

    Science.gov (United States)

    Görgens, Christian; Guddat, Sven; Dib, Josef; Geyer, Hans; Schänzer, Wilhelm; Thevis, Mario

    2015-01-01

    To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system (CNS) functions. In the present study, the existing evidence of Mildronate's usage in sport, which is arguably not (exclusively) based on medicinal reasons, is corroborated by unequivocal analytical data allowing the estimation of the prevalence and extent of misuse in professional sports. Such data are vital to support decision-making processes, particularly regarding the ban on drugs in sport. Due to the growing body of evidence (black market products and athlete statements) concerning its misuse in sport, adequate test methods for the reliable identification of Mildronate are required, especially since the substance has been added to the 2015 World Anti-Doping Agency (WADA) monitoring program. In the present study, two approaches were established using an in-house synthesized labelled internal standard (Mildronate-D3 ). One aimed at the implementation of the analyte into routine doping control screening methods to enable its monitoring at the lowest possible additional workload for the laboratory, and another that is appropriate for the peculiar specifics of the analyte, allowing the unequivocal confirmation of findings using hydrophilic interaction liquid chromatography-high resolution/high accuracy mass spectrometry (HILIC-HRMS). Here, according to applicable regulations in sports drug testing, a full qualitative validation was conducted. The assay demonstrated good specificity, robustness (rRT=0.3%), precision (intra-day: 7.0-8.4%; inter-day: 9.9-12.9%), excellent linearity (R>0.99) and an adequate lower limit of detection (<10 ng/mL). Copyright © 2015 John Wiley & Sons, Ltd.

  15. Mildronate (Meldonium) in professional sports – monitoring doping control urine samples using hydrophilic interaction liquid chromatography – high resolution/high accuracy mass spectrometry

    Science.gov (United States)

    Görgens, Christian; Dib, Josef; Geyer, Hans; Schänzer, Wilhelm; Thevis, Mario

    2015-01-01

    To date, substances such as Mildronate (Meldonium) are not on the radar of anti‐doping laboratories as the compound is not explicitly classified as prohibited. However, the anti‐ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system (CNS) functions. In the present study, the existing evidence of Mildronate's usage in sport, which is arguably not (exclusively) based on medicinal reasons, is corroborated by unequivocal analytical data allowing the estimation of the prevalence and extent of misuse in professional sports. Such data are vital to support decision‐making processes, particularly regarding the ban on drugs in sport. Due to the growing body of evidence (black market products and athlete statements) concerning its misuse in sport, adequate test methods for the reliable identification of Mildronate are required, especially since the substance has been added to the 2015 World Anti‐Doping Agency (WADA) monitoring program. In the present study, two approaches were established using an in‐house synthesized labelled internal standard (Mildronate‐D3). One aimed at the implementation of the analyte into routine doping control screening methods to enable its monitoring at the lowest possible additional workload for the laboratory, and another that is appropriate for the peculiar specifics of the analyte, allowing the unequivocal confirmation of findings using hydrophilic interaction liquid chromatography‐high resolution/high accuracy mass spectrometry (HILIC‐HRMS). Here, according to applicable regulations in sports drug testing, a full qualitative validation was conducted. The assay demonstrated good specificity, robustness (rRT=0.3%), precision (intra‐day: 7.0–8.4%; inter‐day: 9.9–12.9%), excellent linearity (R>0.99) and an adequate lower limit of detection (<10 ng/mL). © 2015 The Authors

  16. Improving the accuracy of dynamic mass calculation

    Directory of Open Access Journals (Sweden)

    Oleksandr F. Dashchenko

    2015-06-01

    Full Text Available With the acceleration of goods transporting, cargo accounting plays an important role in today's global and complex environment. Weight is the most reliable indicator of the materials control. Unlike many other variables that can be measured indirectly, the weight can be measured directly and accurately. Using strain-gauge transducers, weight value can be obtained within a few milliseconds; such values correspond to the momentary load, which acts on the sensor. Determination of the weight of moving transport is only possible by appropriate processing of the sensor signal. The aim of the research is to develop a methodology for weighing freight rolling stock, which increases the accuracy of the measurement of dynamic mass, in particular wagon that moves. Apart from time-series methods, preliminary filtration for improving the accuracy of calculation is used. The results of the simulation are presented.

  17. High accuracy experimental determination of copper and zinc mass attenuation coefficients in the 100 eV to 30 keV photon energy range

    Science.gov (United States)

    Ménesguen, Y.; Gerlach, M.; Pollakowski, B.; Unterumsberger, R.; Haschke, M.; Beckhoff, B.; Lépy, M.-C.

    2016-02-01

    The knowledge of atomic fundamental parameters such as mass attenuation coefficients with low uncertainties, is of decisive importance in elemental quantification using x-ray fluorescence analysis techniques. Several databases are accessible and frequently used within a large community of users. These compilations are most often in good agreement for photon energies in the hard x-ray ranges. However, they significantly differ for low photon energies and around the absorption edges of any element. In a joint cooperation of the metrology institutes of France and Germany, mass attenuation coefficients of copper and zinc were determined experimentally in the photon energy range from 100 eV to 30 keV by independent approaches using monochromatized synchrotron radiation at SOLEIL (France) and BESSY II (Germany), respectively. The application of high-accuracy experimental techniques resulted in mass attenuation coefficient datasets determined with low uncertainties that are directly compared to existing databases. The novel datasets are expected to enhance the reliability of mass attenuation coefficients.

  18. Response-only method for damage detection of beam-like structures using high accuracy frequencies with auxiliary mass spatial probing

    Science.gov (United States)

    Zhong, Shuncong; Oyadiji, S. Olutunde; Ding, Kang

    2008-04-01

    This paper proposes a new approach based on auxiliary mass spatial probing using spectral centre correction method (SCCM), to provide a simple solution for damage detection by just using the response time history of beam-like structures. The natural frequencies of a damaged beam with a traversing auxiliary mass change due to change in the inertia of the beam as the auxiliary mass is traversed along the beam, as well as the point-to-point variations in the flexibility of the beam. Therefore the auxiliary mass can enhance the effects of the crack on the dynamics of the beam and, therefore, facilitate the identification and location of damage in the beam. That is, the auxiliary mass can be used to probe the dynamic characteristic of the beam by traversing the mass from one end of the beam to the other. However, it is impossible to obtain accurate modal frequencies by the direct operation of the fast Fourier transform (FFT) of the response data of the structure because the frequency spectrum can be only calculated from limited sampled time data which results in the well-known leakage effect. SCCM is identical to the energy centrobaric correction method (ECCM) which is a practical and effective method used in rotating mechanical fault diagnosis and which resolves the shortcoming of FFT and can provide high accuracy estimate of frequency, amplitude and phase. In the present work, the modal responses of damaged simply supported beams with auxiliary mass are computed using the finite element method (FEM). The graphical plots of the natural frequencies calculated by SCCM versus axial location of auxiliary mass are obtained. However, it is difficult to locate the crack directly from the curve of natural frequencies. A simple and fast method, the derivatives of natural frequency curve, is proposed in the paper which can provide crack information for damage detection of beam-like structures. The efficiency and practicability of the proposed method is illustrated via numerical

  19. Mechanism of [m+h]+ formation in atmospheric pressure photoionization mass spectrometry: identification of propionitrile in acetonitrile with high mass accuracy measurement and tandem mass spectrometry and evidence for its involvement in the protonation phenomenon.

    Science.gov (United States)

    Kamel, Amin; Jeanville, Patrick; Colizza, Kevin; J-Rivera, Lauren Elizabeth

    2008-11-01

    The role of propionitrile in the production of [M+H]+ under atmospheric pressure photoionization (APPI) was investigated. In dopant-assisted APPI using acetone and anisole, protonated acetone and anisole radical cations were the most prominent ions observed. In dopant-free or direct APPI in acetonitrile, however, a major ion in acetonitrile was detected and identified as propionitrile, using high accuracy mass measurement and collision induced dissociation studies. Vaporizing ca. 10(-5) M althiazide and bendroflumethazide under direct APPI in acetonitrile produced their corresponding protonated species [M+H]+. In addition to protonated acetonitrile, its dimers, and acetonitrile/water clusters, protonated propionitrile, propionitrile dimer, and propionitrile/water clusters were also observed. The role of propionitrile, an impurity in acetonitrile and/or a possible product of ion-molecule reaction, in the production of [M+H]+ of althiazide and bendroflumethazide was further investigated in the absence of dopant using propionitrile-d5. The formation of [M+D]+ species was observed, suggesting a possible role of propionitrile in the protonation process. Additionally, an increase in the [M+H]+ signal of althiazide and bendroflumethazide was observed as a function of propionitrile concentration in acetonitrile. Theoretical data from the literature supported the assumption that one possible mechanism, among others, for the formation of [M+H]+ could be attributed to photo-initiated isomerization of propionitrile. The most stable isomers of propionitrile, based on their calculated ionization energy (IE) and relative energy (DeltaE), were assumed to undergo proton transfer to the analytes, and mechanisms were proposed.

  20. "Dilute-and-inject" multi-target screening assay for highly polar doping agents using hydrophilic interaction liquid chromatography high resolution/high accuracy mass spectrometry for sports drug testing.

    Science.gov (United States)

    Görgens, Christian; Guddat, Sven; Orlovius, Anne-Katrin; Sigmund, Gerd; Thomas, Andreas; Thevis, Mario; Schänzer, Wilhelm

    2015-07-01

    In the field of LC-MS, reversed phase liquid chromatography is the predominant method of choice for the separation of prohibited substances from various classes in sports drug testing. However, highly polar and charged compounds still represent a challenging task in liquid chromatography due to their difficult chromatographic behavior using reversed phase materials. A very promising approach for the separation of hydrophilic compounds is hydrophilic interaction liquid chromatography (HILIC). Despite its great potential and versatile advantages for the separation of highly polar compounds, HILIC is up to now not very common in doping analysis, although most manufacturers offer a variety of HILIC columns in their portfolio. In this study, a novel multi-target approach based on HILIC high resolution/high accuracy mass spectrometry is presented to screen for various polar stimulants, stimulant sulfo-conjugates, glycerol, AICAR, ethyl glucuronide, morphine-3-glucuronide, and myo-inositol trispyrophosphate after direct injection of diluted urine specimens. The usage of an effective online sample cleanup and a zwitterionic HILIC analytical column in combination with a new generation Hybrid Quadrupol-Orbitrap® mass spectrometer enabled the detection of highly polar analytes without any time-consuming hydrolysis or further purification steps, far below the required detection limits. The methodology was fully validated for qualitative and quantitative (AICAR, glycerol) purposes considering the parameters specificity; robustness (rRT  0.99); intra- and inter-day precision at low, medium, and high concentration levels (CV < 20%); limit of detection (stimulants and stimulant sulfo-conjugates < 10 ng/mL; norfenefrine; octopamine < 30 ng/mL; AICAR < 10 ng/mL; glycerol 100 μg/mL; ETG < 100 ng/mL); accuracy (AICAR 103.8-105.5%, glycerol 85.1-98.3% at three concentration levels) and ion suppression/enhancement effects.

  1. High current high accuracy IGBT pulse generator

    International Nuclear Information System (INIS)

    Nesterov, V.V.; Donaldson, A.R.

    1995-05-01

    A solid state pulse generator capable of delivering high current triangular or trapezoidal pulses into an inductive load has been developed at SLAC. Energy stored in a capacitor bank of the pulse generator is switched to the load through a pair of insulated gate bipolar transistors (IGBT). The circuit can then recover the remaining energy and transfer it back to the capacitor bank without reversing the capacitor voltage. A third IGBT device is employed to control the initial charge to the capacitor bank, a command charging technique, and to compensate for pulse to pulse power losses. The rack mounted pulse generator contains a 525 μF capacitor bank. It can deliver 500 A at 900V into inductive loads up to 3 mH. The current amplitude and discharge time are controlled to 0.02% accuracy by a precision controller through the SLAC central computer system. This pulse generator drives a series pair of extraction dipoles

  2. Validation of an ultra-high-performance liquid chromatography-tandem mass spectrometry method to quantify illicit drug and pharmaceutical residues in wastewater using accuracy profile approach.

    Science.gov (United States)

    Hubert, Cécile; Roosen, Martin; Levi, Yves; Karolak, Sara

    2017-06-02

    The analysis of biomarkers in wastewater has become a common approach to assess community behavior. This method is an interesting way to estimate illicit drug consumption in a given population: by using a back calculation method, it is therefore possible to quantify the amount of a specific drug used in a community and to assess the consumption variation at different times and locations. Such a method needs reliable analytical data since the determination of a concentration in the ngL -1 range in a complex matrix is difficult and not easily reproducible. The best analytical method is liquid chromatography - mass spectrometry coupling after solid-phase extraction or on-line pre-concentration. Quality criteria are not specially defined for this kind of determination. In this context, it was decided to develop an UHPLC-MS/MS method to analyze 10 illicit drugs and pharmaceuticals in wastewater treatment plant influent or effluent using a pre-concentration on-line system. A validation process was then carried out using the accuracy profile concept as an innovative tool to estimate the probability of getting prospective results within specified acceptance limits. Influent and effluent samples were spiked with known amounts of the 10 compounds and analyzed three times a day for three days in order to estimate intra-day and inter-day variations. The matrix effect was estimated for each compound. The developed method can provide at least 80% of results within ±25% limits except for compounds that are degraded in influent. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Precision and accuracy of β gauge for aerosol mass determinations

    International Nuclear Information System (INIS)

    Courtney, W.J.; Shaw, R.W.; Dzabay, T.G.

    1982-01-01

    Results of an experimental determination of the precision and the accuracy of a β-ray attenuation method for measurement of aerosol mass are presented. The instrumental precision for a short-term experiment was 25 μg for a 6.5-cm 2 deposit collected on approximately 1 mg/cm 2 Teflon filters; for a longer-term experiment the precision was 27 μg. The precision of the gravimetric determinations of aerosol deposits was 22 μg for Teflon filters weighed to 1 μg. Filter reorientation and air density changes that were able adversely to affect the β-ray attenuation results are discussed. β-ray attenuation results are in good agreement with gravimetric measurements on the same filter-collected aerosols. Using dichotomous samplers in Durham, NC, we collected 136 aerosol samples on Teflon filters in two size ranges. A regression line was calculated implicitly assuming errors in both measurements of mass. The 90% confidence intervals lay within 21 μg of the regression line for mean fine fraction aerosol mass loadings of 536 μg and within 19 μg of the regression line for mean coarse fraction aerosol mass loadings of 349 μg. Any bias between gravimetric and β-gauge mass measurements was found to be less than 5%

  4. High Accuracy Transistor Compact Model Calibrations

    Energy Technology Data Exchange (ETDEWEB)

    Hembree, Charles E. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Mar, Alan [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Robertson, Perry J. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    Typically, transistors are modeled by the application of calibrated nominal and range models. These models consists of differing parameter values that describe the location and the upper and lower limits of a distribution of some transistor characteristic such as current capacity. Correspond- ingly, when using this approach, high degrees of accuracy of the transistor models are not expected since the set of models is a surrogate for a statistical description of the devices. The use of these types of models describes expected performances considering the extremes of process or transistor deviations. In contrast, circuits that have very stringent accuracy requirements require modeling techniques with higher accuracy. Since these accurate models have low error in transistor descriptions, these models can be used to describe part to part variations as well as an accurate description of a single circuit instance. Thus, models that meet these stipulations also enable the calculation of quantifi- cation of margins with respect to a functional threshold and uncertainties in these margins. Given this need, new model high accuracy calibration techniques for bipolar junction transis- tors have been developed and are described in this report.

  5. High accuracy FIONA-AFM hybrid imaging

    International Nuclear Information System (INIS)

    Fronczek, D.N.; Quammen, C.; Wang, H.; Kisker, C.; Superfine, R.; Taylor, R.; Erie, D.A.; Tessmer, I.

    2011-01-01

    Multi-protein complexes are ubiquitous and play essential roles in many biological mechanisms. Single molecule imaging techniques such as electron microscopy (EM) and atomic force microscopy (AFM) are powerful methods for characterizing the structural properties of multi-protein and multi-protein-DNA complexes. However, a significant limitation to these techniques is the ability to distinguish different proteins from one another. Here, we combine high resolution fluorescence microscopy and AFM (FIONA-AFM) to allow the identification of different proteins in such complexes. Using quantum dots as fiducial markers in addition to fluorescently labeled proteins, we are able to align fluorescence and AFM information to ≥8 nm accuracy. This accuracy is sufficient to identify individual fluorescently labeled proteins in most multi-protein complexes. We investigate the limitations of localization precision and accuracy in fluorescence and AFM images separately and their effects on the overall registration accuracy of FIONA-AFM hybrid images. This combination of the two orthogonal techniques (FIONA and AFM) opens a wide spectrum of possible applications to the study of protein interactions, because AFM can yield high resolution (5-10 nm) information about the conformational properties of multi-protein complexes and the fluorescence can indicate spatial relationships of the proteins in the complexes. -- Research highlights: → Integration of fluorescent signals in AFM topography with high (<10 nm) accuracy. → Investigation of limitations and quantitative analysis of fluorescence-AFM image registration using quantum dots. → Fluorescence center tracking and display as localization probability distributions in AFM topography (FIONA-AFM). → Application of FIONA-AFM to a biological sample containing damaged DNA and the DNA repair proteins UvrA and UvrB conjugated to quantum dots.

  6. Accuracy of Body Mass Index Versus Lean Mass Index for Prediction of Sarcopenia in Older Women.

    Science.gov (United States)

    Benton, M J; Silva-Smith, A L

    2018-01-01

    We compared accuracy of body mass index (BMI) versus lean mass index (LMI) to predict sarcopenia in 58 community-dwelling women (74.1±0.9 years). Lean mass was measured with multi-frequency bioelectrical impedance analysis, and strength was measured with Arm Curl test, Chair Stand test, and handgrip dynamometry. Sarcopenia was defined as low LMI. When categorized by BMI, normal women had less absolute lean mass (37.6±1.0 vs. 42.6±0.9 kg; Plean mass (14.1±0.2 vs. 16.1±0.2 kg/m2; Plean mass (44.0±0.7 vs. 35.7±0.7 kg; Plean mass (16.2±0.2 vs. 13.8±0.2 kg/m2; Plean mass and strength. For clinical assessment, calculation of LMI rather than BMI is appropriate.

  7. High accuracy 3-D laser radar

    DEFF Research Database (Denmark)

    Busck, Jens; Heiselberg, Henning

    2004-01-01

    We have developed a mono-static staring 3-D laser radar based on gated viewing with range accuracy below 1 m at 10 m and 1 cm at 100. We use a high sensitivity, fast, intensified CCD camera, and a Nd:Yag passively Q-switched 32.4 kHz pulsed green laser at 532 nm. The CCD has 752x582 pixels. Camera...

  8. A simple algorithm improves mass accuracy to 50-100 ppm for delayed extraction linear MALDI-TOF mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Hack, Christopher A.; Benner, W. Henry

    2001-10-31

    A simple mathematical technique for improving mass calibration accuracy of linear delayed extraction matrix assisted laser desorption ionization time-of-flight mass spectrometry (DE MALDI-TOF MS) spectra is presented. The method involves fitting a parabola to a plot of Dm vs. mass data where Dm is the difference between the theoretical mass of calibrants and the mass obtained from a linear relationship between the square root of m/z and ion time of flight. The quadratic equation that describes the parabola is then used to correct the mass of unknowns by subtracting the deviation predicted by the quadratic equation from measured data. By subtracting the value of the parabola at each mass from the calibrated data, the accuracy of mass data points can be improved by factors of 10 or more. This method produces highly similar results whether or not initial ion velocity is accounted for in the calibration equation; consequently, there is no need to depend on that uncertain parameter when using the quadratic correction. This method can be used to correct the internally calibrated masses of protein digest peaks. The effect of nitrocellulose as a matrix additive is also briefly discussed, and it is shown that using nitrocellulose as an additive to a CHCA matrix does not significantly change initial ion velocity but does change the average position of ions relative to the sample electrode at the instant the extraction voltage is applied.

  9. ON THE ACCURACY OF WEAK-LENSING CLUSTER MASS RECONSTRUCTIONS

    International Nuclear Information System (INIS)

    Becker, Matthew R.; Kravtsov, Andrey V.

    2011-01-01

    We study the bias and scatter in mass measurements of galaxy clusters resulting from fitting a spherically symmetric Navarro, Frenk, and White model to the reduced tangential shear profile measured in weak-lensing (WL) observations. The reduced shear profiles are generated for ∼10 4 cluster-sized halos formed in a ΛCDM cosmological N-body simulation of a 1 h -1 Gpc box. In agreement with previous studies, we find that the scatter in the WL masses derived using this fitting method has irreducible contributions from the triaxial shapes of cluster-sized halos and uncorrelated large-scale matter projections along the line of sight. Additionally, we find that correlated large-scale structure within several virial radii of clusters contributes a smaller, but nevertheless significant, amount to the scatter. The intrinsic scatter due to these physical sources is ∼20% for massive clusters and can be as high as ∼30% for group-sized systems. For current, ground-based observations, however, the total scatter should be dominated by shape noise from the background galaxies used to measure the shear. Importantly, we find that WL mass measurements can have a small, ∼5%-10%, but non-negligible amount of bias. Given that WL measurements of cluster masses are a powerful way to calibrate cluster mass-observable relations for precision cosmological constraints, we strongly emphasize that a robust calibration of the bias requires detailed simulations that include more observational effects than we consider here. Such a calibration exercise needs to be carried out for each specific WL mass estimation method, as the details of the method determine in part the expected scatter and bias. We present an iterative method for estimating mass M 500c that can eliminate the bias for analyses of ground-based data.

  10. High accuracy satellite drag model (HASDM)

    Science.gov (United States)

    Storz, Mark F.; Bowman, Bruce R.; Branson, Major James I.; Casali, Stephen J.; Tobiska, W. Kent

    The dominant error source in force models used to predict low-perigee satellite trajectories is atmospheric drag. Errors in operational thermospheric density models cause significant errors in predicted satellite positions, since these models do not account for dynamic changes in atmospheric drag for orbit predictions. The Air Force Space Battlelab's High Accuracy Satellite Drag Model (HASDM) estimates and predicts (out three days) a dynamically varying global density field. HASDM includes the Dynamic Calibration Atmosphere (DCA) algorithm that solves for the phases and amplitudes of the diurnal and semidiurnal variations of thermospheric density near real-time from the observed drag effects on a set of Low Earth Orbit (LEO) calibration satellites. The density correction is expressed as a function of latitude, local solar time and altitude. In HASDM, a time series prediction filter relates the extreme ultraviolet (EUV) energy index E10.7 and the geomagnetic storm index ap, to the DCA density correction parameters. The E10.7 index is generated by the SOLAR2000 model, the first full spectrum model of solar irradiance. The estimated and predicted density fields will be used operationally to significantly improve the accuracy of predicted trajectories for all low-perigee satellites.

  11. Fast and High Accuracy Wire Scanner

    CERN Document Server

    Koujili, M; Koopman, J; Ramos, D; Sapinski, M; De Freitas, J; Ait Amira, Y; Djerdir, A

    2009-01-01

    Scanning of a high intensity particle beam imposes challenging requirements on a Wire Scanner system. It is expected to reach a scanning speed of 20 m.s-1 with a position accuracy of the order of 1 μm. In addition a timing accuracy better than 1 millisecond is needed. The adopted solution consists of a fork holding a wire rotating by a maximum of 200°. Fork, rotor and angular position sensor are mounted on the same axis and located in a chamber connected to the beam vacuum. The requirements imply the design of a system with extremely low vibration, vacuum compatibility, radiation and temperature tolerance. The adopted solution consists of a rotary brushless synchronous motor with the permanent magnet rotor installed inside of the vacuum chamber and the stator installed outside. The accurate position sensor will be mounted on the rotary shaft inside of the vacuum chamber, has to resist a bake-out temperature of 200°C and ionizing radiation up to a dozen of kGy/year. A digital feedback controller allows maxi...

  12. An algorithm to correct saturated mass spectrometry ion abundances for enhanced quantitation and mass accuracy in omic studies

    Energy Technology Data Exchange (ETDEWEB)

    Bilbao, Aivett; Gibbons, Bryson C.; Slysz, Gordon W.; Crowell, Kevin L.; Monroe, Matthew E.; Ibrahim, Yehia M.; Smith, Richard D.; Payne, Samuel H.; Baker, Erin S.

    2018-04-01

    The mass accuracy and peak intensity of ions detected by mass spectrometry (MS) measurements are essential to facilitate compound identification and quantitation. However, high concentration species can easily cause problems if their ion intensities reach beyond the limits of the detection system, leading to distorted and non-ideal detector response (e.g. saturation), and largely precluding the calculation of accurate m/z and intensity values. Here we present an open source computational method to correct peaks above a defined intensity (saturated) threshold determined by the MS instrumentation such as the analog-to-digital converters or time-to-digital converters used in conjunction with time-of-flight MS. In this method, the isotopic envelope for each observed ion above the saturation threshold is compared to its expected theoretical isotopic distribution. The most intense isotopic peak for which saturation does not occur is then utilized to re-calculate the precursor m/z and correct the intensity, resulting in both higher mass accuracy and greater dynamic range. The benefits of this approach were evaluated with proteomic and lipidomic datasets of varying complexities. After correcting the high concentration species, reduced mass errors and enhanced dynamic range were observed for both simple and complex omic samples. Specifically, the mass error dropped by more than 50% in most cases with highly saturated species and dynamic range increased by 1-2 orders of magnitude for peptides in a blood serum sample.

  13. Molecular Isotopic Distribution Analysis (MIDAs) with adjustable mass accuracy.

    Science.gov (United States)

    Alves, Gelio; Ogurtsov, Aleksey Y; Yu, Yi-Kuo

    2014-01-01

    In this paper, we present Molecular Isotopic Distribution Analysis (MIDAs), a new software tool designed to compute molecular isotopic distributions with adjustable accuracies. MIDAs offers two algorithms, one polynomial-based and one Fourier-transform-based, both of which compute molecular isotopic distributions accurately and efficiently. The polynomial-based algorithm contains few novel aspects, whereas the Fourier-transform-based algorithm consists mainly of improvements to other existing Fourier-transform-based algorithms. We have benchmarked the performance of the two algorithms implemented in MIDAs with that of eight software packages (BRAIN, Emass, Mercury, Mercury5, NeutronCluster, Qmass, JFC, IC) using a consensus set of benchmark molecules. Under the proposed evaluation criteria, MIDAs's algorithms, JFC, and Emass compute with comparable accuracy the coarse-grained (low-resolution) isotopic distributions and are more accurate than the other software packages. For fine-grained isotopic distributions, we compared IC, MIDAs's polynomial algorithm, and MIDAs's Fourier transform algorithm. Among the three, IC and MIDAs's polynomial algorithm compute isotopic distributions that better resemble their corresponding exact fine-grained (high-resolution) isotopic distributions. MIDAs can be accessed freely through a user-friendly web-interface at http://www.ncbi.nlm.nih.gov/CBBresearch/Yu/midas/index.html.

  14. Soft Tissue Masses in the Extremities: The Accuracy of an Ultrasonographic Diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    An, Ji Young; Park, So Young; Park, Ji Seon; Jin, Wook; Ryu, Kyung Nam [Kyung Hee University Medical Center, Seoul (Korea, Republic of)

    2011-09-15

    We wanted to retrospectively determine the accuracy of an ultrasonographic diagnosis of superficial soft tissue masses in the extremities by using the histologic results as the reference standard. From January 2005 to June 2010, 154 patients with soft tissue masses in the extremities and who underwent ultrasonographic evaluation followed by biopsy or resection were retrospectively evaluated. The ultrasonographic and histologic diagnoses of the soft tissue masses were lipoma, ganglion cyst, hemangioma, neurogenic tumor, giant cell tumor of the tendon sheath, epidermoid cyst, fibroma, glomus tumor, Baker's cyst and neurofibromatosis. Out of 154 patients, 114 (74%) patients showed concordance between the histologic diagnosis and the ultrasonographic diagnosis, and the remaining 40 (26%) patients did not. The diagnostic accuracy of each soft tissue mass was 95% for lipoma, 83% for ganglion cyst, 75% for hemangioma, 72% for neurogenic tumor, 50% for giant cell tumor of the tendon sheath, 43% for epidermoid cyst, 33% for fibroma and 100% each for glomus tumor, fibromatosis and Baker's cyst. Aside from these tumors, there were also sarcoma, malignant melanoma, elastofibroma, Kimura disease and pilomatricoma. Among the cases that showed discordance between the histologic diagnosis and the ultrasonographic diagnosis, three of them were notable; pilomatricoma being misdiagnosed as dermatofibroma protuberans, angiolipoma being misdiagnosed as vascular leiomyoma and malignant fibrous histiocytoma being misdiagnosed as a malignant soft tissue mass. The accuracy of an ultrasonographic diagnosis for soft tissue masses in the extremities varies greatly according to each type of mass. Lipoma, ganglion cyst, hemangioma, glomus tumor, neurogenic tumor and Baker's cyst showed a relatively high rate of concordance between the ultrasonographic diagnosis and the histologic diagnosis, but epidermoid cyst and fibroma showed a relatively lower rate of concordance

  15. Establishing the accuracy of asteroseismic mass and radius estimates of giant stars - I. Three eclipsing systems at [Fe/H] ˜ -0.3 and the need for a large high-precision sample

    Science.gov (United States)

    Brogaard, K.; Hansen, C. J.; Miglio, A.; Slumstrup, D.; Frandsen, S.; Jessen-Hansen, J.; Lund, M. N.; Bossini, D.; Thygesen, A.; Davies, G. R.; Chaplin, W. J.; Arentoft, T.; Bruntt, H.; Grundahl, F.; Handberg, R.

    2018-05-01

    We aim to establish and improve the accuracy level of asteroseismic estimates of mass, radius, and age of giant stars. This can be achieved by measuring independent, accurate, and precise masses, radii, effective temperatures and metallicities of long period eclipsing binary stars with a red giant component that displays solar-like oscillations. We measured precise properties of the three eclipsing binary systems KIC 7037405, KIC 9540226, and KIC 9970396 and estimated their ages be 5.3 ± 0.5, 3.1 ± 0.6, and 4.8 ± 0.5 Gyr. The measurements of the giant stars were compared to corresponding measurements of mass, radius, and age using asteroseismic scaling relations and grid modelling. We found that asteroseismic scaling relations without corrections to Δν systematically overestimate the masses of the three red giants by 11.7 per cent, 13.7 per cent, and 18.9 per cent, respectively. However, by applying theoretical correction factors fΔν according to Rodrigues et al. (2017), we reached general agreement between dynamical and asteroseismic mass estimates, and no indications of systematic differences at the precision level of the asteroseismic measurements. The larger sample investigated by Gaulme et al. (2016) showed a much more complicated situation, where some stars show agreement between the dynamical and corrected asteroseismic measures while others suggest significant overestimates of the asteroseismic measures. We found no simple explanation for this, but indications of several potential problems, some theoretical, others observational. Therefore, an extension of the present precision study to a larger sample of eclipsing systems is crucial for establishing and improving the accuracy of asteroseismology of giant stars.

  16. Metabolomic database annotations via query of elemental compositions: Mass accuracy is insufficient even at less than 1 ppm

    Directory of Open Access Journals (Sweden)

    Fiehn Oliver

    2006-04-01

    Full Text Available Abstract Background Metabolomic studies are targeted at identifying and quantifying all metabolites in a given biological context. Among the tools used for metabolomic research, mass spectrometry is one of the most powerful tools. However, metabolomics by mass spectrometry always reveals a high number of unknown compounds which complicate in depth mechanistic or biochemical understanding. In principle, mass spectrometry can be utilized within strategies of de novo structure elucidation of small molecules, starting with the computation of the elemental composition of an unknown metabolite using accurate masses with errors Results High mass accuracy (95% of false candidates. This orthogonal filter can condense several thousand candidates down to only a small number of molecular formulas. Example calculations for 10, 5, 3, 1 and 0.1 ppm mass accuracy are given. Corresponding software scripts can be downloaded from http://fiehnlab.ucdavis.edu. A comparison of eight chemical databases revealed that PubChem and the Dictionary of Natural Products can be recommended for automatic queries using molecular formulae. Conclusion More than 1.6 million molecular formulae in the range 0–500 Da were generated in an exhaustive manner under strict observation of mathematical and chemical rules. Assuming that ion species are fully resolved (either by chromatography or by high resolution mass spectrometry, we conclude that a mass spectrometer capable of 3 ppm mass accuracy and 2% error for isotopic abundance patterns outperforms mass spectrometers with less than 1 ppm mass accuracy or even hypothetical mass spectrometers with 0.1 ppm mass accuracy that do not include isotope information in the calculation of molecular formulae.

  17. Electron ray tracing with high accuracy

    International Nuclear Information System (INIS)

    Saito, K.; Okubo, T.; Takamoto, K.; Uno, Y.; Kondo, M.

    1986-01-01

    An electron ray tracing program is developed to investigate the overall geometrical and chromatic aberrations in electron optical systems. The program also computes aberrations due to manufacturing errors in lenses and deflectors. Computation accuracy is improved by (1) calculating electrostatic and magnetic scalar potentials using the finite element method with third-order isoparametric elements, and (2) solving the modified ray equation which the aberrations satisfy. Computation accuracy of 4 nm is achieved for calculating optical properties of the system with an electrostatic lens

  18. Improving mass measurement accuracy in mass spectrometry based proteomics by combining open source tools for chromatographic alignment and internal calibration.

    Science.gov (United States)

    Palmblad, Magnus; van der Burgt, Yuri E M; Dalebout, Hans; Derks, Rico J E; Schoenmaker, Bart; Deelder, André M

    2009-05-02

    Accurate mass determination enhances peptide identification in mass spectrometry based proteomics. We here describe the combination of two previously published open source software tools to improve mass measurement accuracy in Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS). The first program, msalign, aligns one MS/MS dataset with one FTICRMS dataset. The second software, recal2, uses peptides identified from the MS/MS data for automated internal calibration of the FTICR spectra, resulting in sub-ppm mass measurement errors.

  19. Diagnostic accuracy of percutaneous cytodiagnosis of hepatic masses, by ultrasound guided fine needle aspiration cytology

    International Nuclear Information System (INIS)

    Asghar, F.; Riaz, S.

    2010-01-01

    Objective: To evaluate the diagnostic accuracy, usefulness and limitations of ultrasound guided FNAC of hepatic masses. Design: Cross - sectional analytical (comparative study). Place and Duration: Department of histopathology, Sheikh Zayed Hospital, Lahore. Study period 1 year. Material and Methods: A total of 32 patients with solitary or multiple hepatic masses underwent FNAC from March 1999 to March 2000. Adequate aspirates were obtained in all these cases. Smears were stained with May-Grunwald Giemsa, Haematoxylin and Eosin and Papanicolaou stain. Needle biopsies from the same cases were also obtained and processed. These were stained with routine Haematoxylin and Eosin staining. The blood clots obtained during FNAC were fixed in 10% neu-tral buffered formalin. The histopathology of these blood clots was used for cases whose needle core biopsy was not available. The screened FNAC smears were divided into 3 categories i.e., benign (group - I), malignant (group - II), non-neoplastic / inflammatory lesions (including cysts and abscesses) (group - III). Results: Out of 32 cases, 6 were categorized as benign, 18 as malignant, and 8 as non-neoplastic inflammatory lesions. Three false negative diagnoses, including 1 for malignant tumour and 2 for benign tumours was obtained. There was 1 false positive diagnosis for malignancy. FNAC - histological correlation showed a 94.2% sensitivity and 92.3% diagnostic accuracy for malignant tumours, while benign tumours posed maximum diagnostic problems, giving a 66.67% sensitivity and 85.7% diagnostic accuracy. FNAC picked up correctly all the non-neoplastic lesions giving a 100% sensitivity and diagnostic accuracy. Conclusion: Majority of the malignant tumours can be categorized on FNAC, with a high degree of accuracy, while benign tumours should be subjected to biopsy, as there is a relatively greater possibility of false negative diagnosis. (author)

  20. Improved mass resolution and mass accuracy in TOF-SIMS spectra and images using argon gas cluster ion beams.

    Science.gov (United States)

    Shon, Hyun Kyong; Yoon, Sohee; Moon, Jeong Hee; Lee, Tae Geol

    2016-06-09

    The popularity of argon gas cluster ion beams (Ar-GCIB) as primary ion beams in time-of-flight secondary ion mass spectrometry (TOF-SIMS) has increased because the molecular ions of large organic- and biomolecules can be detected with less damage to the sample surfaces. However, Ar-GCIB is limited by poor mass resolution as well as poor mass accuracy. The inferior quality of the mass resolution in a TOF-SIMS spectrum obtained by using Ar-GCIB compared to the one obtained by a bismuth liquid metal cluster ion beam and others makes it difficult to identify unknown peaks because of the mass interference from the neighboring peaks. However, in this study, the authors demonstrate improved mass resolution in TOF-SIMS using Ar-GCIB through the delayed extraction of secondary ions, a method typically used in TOF mass spectrometry to increase mass resolution. As for poor mass accuracy, although mass calibration using internal peaks with low mass such as hydrogen and carbon is a common approach in TOF-SIMS, it is unsuited to the present study because of the disappearance of the low-mass peaks in the delayed extraction mode. To resolve this issue, external mass calibration, another regularly used method in TOF-MS, was adapted to enhance mass accuracy in the spectrum and image generated by TOF-SIMS using Ar-GCIB in the delayed extraction mode. By producing spectra analyses of a peptide mixture and bovine serum albumin protein digested with trypsin, along with image analyses of rat brain samples, the authors demonstrate for the first time the enhancement of mass resolution and mass accuracy for the purpose of analyzing large biomolecules in TOF-SIMS using Ar-GCIB through the use of delayed extraction and external mass calibration.

  1. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data

    Science.gov (United States)

    Spraggins, Jeffrey M.; Rizzo, David G.; Moore, Jessica L.; Rose, Kristie L.; Hammer, Neal D.; Skaar, Eric P.; Caprioli, Richard M.

    2015-06-01

    MALDI imaging mass spectrometry is a highly sensitive and selective tool used to visualize biomolecules in tissue. However, identification of detected proteins remains a difficult task. Indirect identification strategies have been limited by insufficient mass accuracy to confidently link ion images to proteomics data. Here, we demonstrate the capabilities of MALDI FTICR MS for imaging intact proteins. MALDI FTICR IMS provides an unprecedented combination of mass resolving power (~75,000 at m/z 5000) and accuracy (differentiate a series of oxidation products of S100A8 ( m/z 10,164.03, -2.1ppm), a subunit of the heterodimer calprotectin, in kidney tissue from mice infected with Staphylococcus aureus. S100A8 - M37O/C42O3 ( m/z 10228.00, -2.6ppm) was found to co-localize with bacterial microcolonies at the center of infectious foci. The ability of MALDI FTICR IMS to distinguish S100A8 modifications is critical to understanding calprotectin's roll in nutritional immunity.

  2. High accuracy magnetic field mapping of the LEP spectrometer magnet

    CERN Document Server

    Roncarolo, F

    2000-01-01

    The Large Electron Positron accelerator (LEP) is a storage ring which has been operated since 1989 at the European Laboratory for Particle Physics (CERN), located in the Geneva area. It is intended to experimentally verify the Standard Model theory and in particular to detect with high accuracy the mass of the electro-weak force bosons. Electrons and positrons are accelerated inside the LEP ring in opposite directions and forced to collide at four locations, once they reach an energy high enough for the experimental purposes. During head-to-head collisions the leptons loose all their energy and a huge amount of energy is concentrated in a small region. In this condition the energy is quickly converted in other particles which tend to go away from the interaction point. The higher the energy of the leptons before the collisions, the higher the mass of the particles that can escape. At LEP four large experimental detectors are accommodated. All detectors are multi purpose detectors covering a solid angle of alm...

  3. Changes in Kicking Pattern: Effect of Experience, Speed, Accuracy, and Effective Striking Mass

    Science.gov (United States)

    Southard, Dan L.

    2014-01-01

    Purpose: The purposes of this study were to: (a) examine the effect of experience and goal constraints (speed, accuracy) on kicking patterns; (b) determine if effective striking mass was independent of ankle velocity at impact; and (c) determine the accuracy of kicks relative to independent factors. Method: Twenty participants were recruited to…

  4. High accuracy in silico sulfotransferase models.

    Science.gov (United States)

    Cook, Ian; Wang, Ting; Falany, Charles N; Leyh, Thomas S

    2013-11-29

    Predicting enzymatic behavior in silico is an integral part of our efforts to understand biology. Hundreds of millions of compounds lie in targeted in silico libraries waiting for their metabolic potential to be discovered. In silico "enzymes" capable of accurately determining whether compounds can inhibit or react is often the missing piece in this endeavor. This problem has now been solved for the cytosolic sulfotransferases (SULTs). SULTs regulate the bioactivities of thousands of compounds--endogenous metabolites, drugs and other xenobiotics--by transferring the sulfuryl moiety (SO3) from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyls and primary amines of these acceptors. SULT1A1 and 2A1 catalyze the majority of sulfation that occurs during human Phase II metabolism. Here, recent insights into the structure and dynamics of SULT binding and reactivity are incorporated into in silico models of 1A1 and 2A1 that are used to identify substrates and inhibitors in a structurally diverse set of 1,455 high value compounds: the FDA-approved small molecule drugs. The SULT1A1 models predict 76 substrates. Of these, 53 were known substrates. Of the remaining 23, 21 were tested, and all were sulfated. The SULT2A1 models predict 22 substrates, 14 of which are known substrates. Of the remaining 8, 4 were tested, and all are substrates. The models proved to be 100% accurate in identifying substrates and made no false predictions at Kd thresholds of 100 μM. In total, 23 "new" drug substrates were identified, and new linkages to drug inhibitors are predicted. It now appears to be possible to accurately predict Phase II sulfonation in silico.

  5. High-Resolution Mass Spectrometers

    Science.gov (United States)

    Marshall, Alan G.; Hendrickson, Christopher L.

    2008-07-01

    Over the past decade, mass spectrometry has been revolutionized by access to instruments of increasingly high mass-resolving power. For small molecules up to ˜400 Da (e.g., drugs, metabolites, and various natural organic mixtures ranging from foods to petroleum), it is possible to determine elemental compositions (CcHhNnOoSsPp…) of thousands of chemical components simultaneously from accurate mass measurements (the same can be done up to 1000 Da if additional information is included). At higher mass, it becomes possible to identify proteins (including posttranslational modifications) from proteolytic peptides, as well as lipids, glycoconjugates, and other biological components. At even higher mass (˜100,000 Da or higher), it is possible to characterize posttranslational modifications of intact proteins and to map the binding surfaces of large biomolecule complexes. Here we review the principles and techniques of the highest-resolution analytical mass spectrometers (time-of-flight and Fourier transform ion cyclotron resonance and orbitrap mass analyzers) and describe some representative high-resolution applications.

  6. High accuracy autonomous navigation using the global positioning system (GPS)

    Science.gov (United States)

    Truong, Son H.; Hart, Roger C.; Shoan, Wendy C.; Wood, Terri; Long, Anne C.; Oza, Dipak H.; Lee, Taesul

    1997-01-01

    The application of global positioning system (GPS) technology to the improvement of the accuracy and economy of spacecraft navigation, is reported. High-accuracy autonomous navigation algorithms are currently being qualified in conjunction with the GPS attitude determination flyer (GADFLY) experiment for the small satellite technology initiative Lewis spacecraft. Preflight performance assessments indicated that these algorithms are able to provide a real time total position accuracy of better than 10 m and a velocity accuracy of better than 0.01 m/s, with selective availability at typical levels. It is expected that the position accuracy will be increased to 2 m if corrections are provided by the GPS wide area augmentation system.

  7. Systematic Calibration for Ultra-High Accuracy Inertial Measurement Units

    Directory of Open Access Journals (Sweden)

    Qingzhong Cai

    2016-06-01

    Full Text Available An inertial navigation system (INS has been widely used in challenging GPS environments. With the rapid development of modern physics, an atomic gyroscope will come into use in the near future with a predicted accuracy of 5 × 10−6°/h or better. However, existing calibration methods and devices can not satisfy the accuracy requirements of future ultra-high accuracy inertial sensors. In this paper, an improved calibration model is established by introducing gyro g-sensitivity errors, accelerometer cross-coupling errors and lever arm errors. A systematic calibration method is proposed based on a 51-state Kalman filter and smoother. Simulation results show that the proposed calibration method can realize the estimation of all the parameters using a common dual-axis turntable. Laboratory and sailing tests prove that the position accuracy in a five-day inertial navigation can be improved about 8% by the proposed calibration method. The accuracy can be improved at least 20% when the position accuracy of the atomic gyro INS can reach a level of 0.1 nautical miles/5 d. Compared with the existing calibration methods, the proposed method, with more error sources and high order small error parameters calibrated for ultra-high accuracy inertial measurement units (IMUs using common turntables, has a great application potential in future atomic gyro INSs.

  8. Relationship between Leg Mass, Leg Composition and Foot Velocity on Kicking Accuracy in Australian Football.

    Science.gov (United States)

    Hart, Nicolas H; Nimphius, Sophia; Spiteri, Tania; Cochrane, Jodie L; Newton, Robert U

    2016-06-01

    Kicking a ball accurately over a desired distance to an intended target is arguably the most important skill to acquire in Australian Football. Therefore, understanding the potential mechanisms which underpin kicking accuracy is warranted. The aim of this study was to examine the relationship between leg mass, leg composition and foot velocity on kicking accuracy in Australian Football. Thirty-one Australian Footballers (n = 31; age: 22.1 ± 2.8 years; height: 1.81 ± 0.07 m; weight: 85.1 ± 13.0 kg; BMI: 25.9 ± 3.2) each performed ten drop punt kicks over twenty metres to a player target. Athletes were separated into accurate (n = 15) and inaccurate (n = 16) kicking groups. Leg mass characteristics were assessed using whole body DXA scans. Foot velocity was determined using a ten-camera optoelectronic, three-dimensional motion capture system. Interactions between leg mass and foot velocity evident within accurate kickers only (r = -0.670 to -0.701). Relative lean mass was positively correlated with kicking accuracy (r = 0.631), while no relationship between foot velocity and kicking accuracy was evident in isolation (r = -0.047 to -0.083). Given the evident importance of lean mass, and its interaction with foot velocity for accurate kickers; future research should explore speed-accuracy, impulse-variability, limb co-ordination and foot-ball interaction constructs in kicking using controlled with-in subject studies to examine the effects of resistance training and skill acquisition programs on the development of kicking accuracy. Key pointsAccurate kickers expressed a very strong inverse relationship between leg mass and foot velocity. Inaccurate kickers were unable to replicate this, with greater volatility in their performance, indicating an ability of accurate kickers to mediate foot velocity to compensate for leg mass in order to deliver the ball over the required distance.Accurate kickers exhibited larger quantities of relative lean mass and lower quantities

  9. MUSCLE: multiple sequence alignment with high accuracy and high throughput.

    Science.gov (United States)

    Edgar, Robert C

    2004-01-01

    We describe MUSCLE, a new computer program for creating multiple alignments of protein sequences. Elements of the algorithm include fast distance estimation using kmer counting, progressive alignment using a new profile function we call the log-expectation score, and refinement using tree-dependent restricted partitioning. The speed and accuracy of MUSCLE are compared with T-Coffee, MAFFT and CLUSTALW on four test sets of reference alignments: BAliBASE, SABmark, SMART and a new benchmark, PREFAB. MUSCLE achieves the highest, or joint highest, rank in accuracy on each of these sets. Without refinement, MUSCLE achieves average accuracy statistically indistinguishable from T-Coffee and MAFFT, and is the fastest of the tested methods for large numbers of sequences, aligning 5000 sequences of average length 350 in 7 min on a current desktop computer. The MUSCLE program, source code and PREFAB test data are freely available at http://www.drive5. com/muscle.

  10. The accuracy of fine-needle aspiration cytology for diagnosis of parotid gland masses: a clinicopathological study of 114 patients

    Directory of Open Access Journals (Sweden)

    Jens Kristjan GUDMUNDSSON

    Full Text Available ABSTRACT Objective Fine-needle aspiration cytology is a valuable method for preoperative assessment of head and neck tumors. However, its accuracy in detection of salivary gland masses is controversial compared with other methods. The aim of this work was to evaluate the effectiveness and accuracy of fine-needle aspiration cytology (FNAC in the diagnosis of parotid gland masses. Material and Methods Over a 10-year period, 126 parotid gland masses were resected. Retrospective chart reviews of 114 patients were performed. The results of FNAC and final histological diagnosis were compared and the accuracy of FNAC was determined. Results Final histological evaluation revealed 11 malignant tumors and 103 benign lesions. Pleomorphic adenoma was the most common neoplasm (63%, followed by Warthin’s tumor (17.5%. The sensitivity of FNAC in detecting malignant tumors was 73% and the specificity was 97%. Positive predictive value (PPV was 73% and negative predictive value (NPV was 97%. The overall accuracy of FNAC in detecting parotid masses was 95%. False-negative diagnosis was found in mucoepidermoid carcinoma, acinic cell carcinoma, and epithelial-myoepithelial carcinoma whereas there was false-positive diagnosis in cases of pleomorphic adenoma and normal parotid gland tissue. Conclusion FNAC is a reliable minimally invasive diagnostic method with a high sensitivity in diagnosis of lesions in parotid glands. The sensitivity of detection of malignant tumors in parotid glands was low due to the biopsy technique used, and depended on tumor location. Postoperative complications decreased after superficial parotidectomy.

  11. Accuracy of Body Mass Index Cutoffs for Classifying Obesity in Chilean Children and Adolescents

    Directory of Open Access Journals (Sweden)

    Rossana Gómez-Campos

    2016-05-01

    Full Text Available Objective: To determine the accuracy of two international Body Mass Index (BMI cut-offs for classifying obesity compared to the percentage of fat mass (%FM assessed by Dual-Energy X-ray Absorptiometry (DXA in a Chilean sample of children and adolescents; Material and Methods: The subjects studied included 280 children and adolescents (125 girls and 155 boys aged 8 to 17 years. Weight and height were measured. The BMI was calculated. Two international references (IOFT and WHO were used as cut-off points. The %FM was assessed by DXA. The receiver operating characteristic (ROC curve was used to assess the performance of BMI in detecting obesity on the basis of %FM; Results: A high correlation was observed between the %FM measured by the DXA and the Z-scores of IOTF and WHO scores in the Chilean adolescents separated by sex (r = 0.78–0.80. Differences occurred in both references (IOFT and WHO in relation to the criteria (p < 0.001. Both references demonstrated a good ability to predict sensitivity (between 84% and 93% and specificity (between 83% and 88% in both sexes of children and adolescents; Conclusions: A high correlation was observed between the Z-score of the BMI with the percentage of fat determined by the DXA. Despite this, the classifications using the different BMI cut-off points showed discrepancies. This suggests that the cut-off points selected to predict obesity in this sample should be viewed with caution.

  12. High mass planets and low mass stars

    International Nuclear Information System (INIS)

    Stevenson, D.J.

    1986-01-01

    The paper on theoretical models of brown dwarf stars was presented to the workshop on ''Astrophysics of brown dwarfs'', Virginia, USA, 1985. The ingredients in the models i.e. equation of state, entropy and the infrared opacity are described. An analytical model is developed which is based on a polytrope (n = 3/4) but which neglects thermonuclear reactions. The model forms the basis of scaling laws for luminosity, mass, opacity and age. Complicating factors in brown dwarf evolution are also discussed. (U.K.)

  13. Dynamic Modeling Accuracy Dependence on Errors in Sensor Measurements, Mass Properties, and Aircraft Geometry

    Science.gov (United States)

    Grauer, Jared A.; Morelli, Eugene A.

    2013-01-01

    A nonlinear simulation of the NASA Generic Transport Model was used to investigate the effects of errors in sensor measurements, mass properties, and aircraft geometry on the accuracy of dynamic models identified from flight data. Measurements from a typical system identification maneuver were systematically and progressively deteriorated and then used to estimate stability and control derivatives within a Monte Carlo analysis. Based on the results, recommendations were provided for maximum allowable errors in sensor measurements, mass properties, and aircraft geometry to achieve desired levels of dynamic modeling accuracy. Results using other flight conditions, parameter estimation methods, and a full-scale F-16 nonlinear aircraft simulation were compared with these recommendations.

  14. Relationship between Leg Mass, Leg Composition and Foot Velocity on Kicking Accuracy in Australian Football

    Directory of Open Access Journals (Sweden)

    Nicolas H. Hart, Jodie L. Cochrane, Tania Spiteri, Sophia Nimphius, Robert U. Newton

    2016-06-01

    Full Text Available Kicking a ball accurately over a desired distance to an intended target is arguably the most important skill to acquire in Australian Football. Therefore, understanding the potential mechanisms which underpin kicking accuracy is warranted. The aim of this study was to examine the relationship between leg mass, leg composition and foot velocity on kicking accuracy in Australian Football. Thirty-one Australian Footballers (n = 31; age: 22.1 ± 2.8 years; height: 1.81 ± 0.07 m; weight: 85.1 ± 13.0 kg; BMI: 25.9 ± 3.2 each performed ten drop punt kicks over twenty metres to a player target. Athletes were separated into accurate (n = 15 and inaccurate (n = 16 kicking groups. Leg mass characteristics were assessed using whole body DXA scans. Foot velocity was determined using a ten-camera optoelectronic, three-dimensional motion capture system. Interactions between leg mass and foot velocity evident within accurate kickers only (r = -0.670 to -0.701. Relative lean mass was positively correlated with kicking accuracy (r = 0.631, while no relationship between foot velocity and kicking accuracy was evident in isolation (r = -0.047 to -0.083. Given the evident importance of lean mass, and its interaction with foot velocity for accurate kickers; future research should explore speed-accuracy, impulse-variability, limb co-ordination and foot-ball interaction constructs in kicking using controlled with-in subject studies to examine the effects of resistance training and skill acquisition programs on the development of kicking accuracy.

  15. On the accuracy of mass measurement for microlensing black holes as seen by Gaia and OGLE

    Science.gov (United States)

    Rybicki, Krzysztof A.; Wyrzykowski, Łukasz; Klencki, Jakub; de Bruijne, Jos; Belczyński, Krzysztof; Chruślińska, Martyna

    2018-05-01

    We investigate the impact of combining Gaia astrometry from space with precise, high cadence OGLE photometry from the ground. For the archival event OGLE3-ULENS-PAR-02, which is likely a black hole, we simulate a realistic astrometric time series of Gaia measurements and combine it with the real photometric data collected by the OGLE project. We predict that at the end of the nominal 5 yr of the Gaia mission, for the events brighter than G ≈ 15.5 mag at the baseline, caused by objects heavier than 10 M⊙, it will be possible to unambiguously derive masses of the lenses, with accuracy between a few and 15 per cent. We find that fainter events (G < 17.5) can still have their lens masses determined, provided that they are heavier than 30 M⊙. We estimate that the rate of astrometric microlensing events caused by the stellar-origin black holes is ≈ 4 × 10- 7 yr- 1, which implies, that after 5 yr of Gaia operation and ≈5 × 106 bright sources in Gaia, it will be possible to identify few such events in the Gaia final catalogues.

  16. High accuracy wavelength calibration for a scanning visible spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Scotti, Filippo; Bell, Ronald E. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

    2010-10-15

    Spectroscopic applications for plasma velocity measurements often require wavelength accuracies {<=}0.2 A. An automated calibration, which is stable over time and environmental conditions without the need to recalibrate after each grating movement, was developed for a scanning spectrometer to achieve high wavelength accuracy over the visible spectrum. This method fits all relevant spectrometer parameters using multiple calibration spectra. With a stepping-motor controlled sine drive, an accuracy of {approx}0.25 A has been demonstrated. With the addition of a high resolution (0.075 arc sec) optical encoder on the grating stage, greater precision ({approx}0.005 A) is possible, allowing absolute velocity measurements within {approx}0.3 km/s. This level of precision requires monitoring of atmospheric temperature and pressure and of grating bulk temperature to correct for changes in the refractive index of air and the groove density, respectively.

  17. High Accuracy Nonlinear Control and Estimation for Machine Tool Systems

    DEFF Research Database (Denmark)

    Papageorgiou, Dimitrios

    Component mass production has been the backbone of industry since the second industrial revolution, and machine tools are producing parts of widely varying size and design complexity. The ever-increasing level of automation in modern manufacturing processes necessitates the use of more...... sophisticated machine tool systems that are adaptable to different workspace conditions, while at the same time being able to maintain very narrow workpiece tolerances. The main topic of this thesis is to suggest control methods that can maintain required manufacturing tolerances, despite moderate wear and tear....... The purpose is to ensure that full accuracy is maintained between service intervals and to advice when overhaul is needed. The thesis argues that quality of manufactured components is directly related to the positioning accuracy of the machine tool axes, and it shows which low level control architectures...

  18. Thermal ionization mass spectrometry (TIMS) of actinides: Pushing the limits of accuracy and detection

    Energy Technology Data Exchange (ETDEWEB)

    Buerger, Stefan; Boulyga, Sergei; Cunningham, Alan; Klose, Dilani; Koepf, Andreas; Poths, Jane [Safeguards Analytical Laboratory, International Atomic Energy Agency, Vienna (Austria); Richter, Stephan [Institute for Reference Materials and Measurements, JRC-EU, Geel (Belgium)

    2010-07-01

    New method developments in multi-collector thermal ionization mass spectrometry (MC-TIMS) for actinide isotope ratio analysis to improve accuracy and limits of detection will be presented. With respect to limits of detection, results on improving work function using various carbon additives will be reviewed and presented as well as developments in cavity ion source (as compared to standard flat ribbon filament ion source) for femto- and attogram levels of uranium, plutonium, and americium. With respect to accuracy, results on isotope ratio measurements of isotopes of uranium (relative accuracy of 0.3% to 0.01%) are presented with an example being U-234-Th-230 age-dating (NBL CRM 112-A). In this context, the importance of traceability (to the S.I. units) and the use of (certified) reference materials are emphasized. The focus of this presentation is on applications to nuclear safeguards / forensics.

  19. The use of low density high accuracy (LDHA) data for correction of high density low accuracy (HDLA) point cloud

    Science.gov (United States)

    Rak, Michal Bartosz; Wozniak, Adam; Mayer, J. R. R.

    2016-06-01

    Coordinate measuring techniques rely on computer processing of coordinate values of points gathered from physical surfaces using contact or non-contact methods. Contact measurements are characterized by low density and high accuracy. On the other hand optical methods gather high density data of the whole object in a short time but with accuracy at least one order of magnitude lower than for contact measurements. Thus the drawback of contact methods is low density of data, while for non-contact methods it is low accuracy. In this paper a method for fusion of data from two measurements of fundamentally different nature: high density low accuracy (HDLA) and low density high accuracy (LDHA) is presented to overcome the limitations of both measuring methods. In the proposed method the concept of virtual markers is used to find a representation of pairs of corresponding characteristic points in both sets of data. In each pair the coordinates of the point from contact measurements is treated as a reference for the corresponding point from non-contact measurement. Transformation enabling displacement of characteristic points from optical measurement to their match from contact measurements is determined and applied to the whole point cloud. The efficiency of the proposed algorithm was evaluated by comparison with data from a coordinate measuring machine (CMM). Three surfaces were used for this evaluation: plane, turbine blade and engine cover. For the planar surface the achieved improvement was of around 200 μm. Similar results were obtained for the turbine blade but for the engine cover the improvement was smaller. For both freeform surfaces the improvement was higher for raw data than for data after creation of mesh of triangles.

  20. Dependence of Dynamic Modeling Accuracy on Sensor Measurements, Mass Properties, and Aircraft Geometry

    Science.gov (United States)

    Grauer, Jared A.; Morelli, Eugene A.

    2013-01-01

    The NASA Generic Transport Model (GTM) nonlinear simulation was used to investigate the effects of errors in sensor measurements, mass properties, and aircraft geometry on the accuracy of identified parameters in mathematical models describing the flight dynamics and determined from flight data. Measurements from a typical flight condition and system identification maneuver were systematically and progressively deteriorated by introducing noise, resolution errors, and bias errors. The data were then used to estimate nondimensional stability and control derivatives within a Monte Carlo simulation. Based on these results, recommendations are provided for maximum allowable errors in sensor measurements, mass properties, and aircraft geometry to achieve desired levels of dynamic modeling accuracy. Results using additional flight conditions and parameter estimation methods, as well as a nonlinear flight simulation of the General Dynamics F-16 aircraft, were compared with these recommendations

  1. Body Mass Index is a Poor Predictor of Bedside Appendix Ultrasound Success or Accuracy

    OpenAIRE

    Lam, Samuel H.F.; Kerwin, Christopher; Konicki, P. John; Goodwine, Diana; Lambert, Michael J.

    2016-01-01

    Introduction: The objective of this study was to determine whether there is a relationship between body mass index (BMI) and success or accuracy rate of beside ultrasound (BUS) for the diagnosis of appendicitis. Methods: Patients four years of age and older presenting to the emergency department with suspected appendicitis were eligible. Enrollment was by convenience sampling. After informed consent, BUS was performed by trained emergency physicians who had undergone a minimum of one-hour...

  2. High-accuracy measurements of the normal specular reflectance

    International Nuclear Information System (INIS)

    Voarino, Philippe; Piombini, Herve; Sabary, Frederic; Marteau, Daniel; Dubard, Jimmy; Hameury, Jacques; Filtz, Jean Remy

    2008-01-01

    The French Laser Megajoule (LMJ) is designed and constructed by the French Commissariata l'Energie Atomique (CEA). Its amplifying section needs highly reflective multilayer mirrors for the flash lamps. To monitor and improve the coating process, the reflectors have to be characterized to high accuracy. The described spectrophotometer is designed to measure normal specular reflectance with high repeatability by using a small spot size of 100 μm. Results are compared with ellipsometric measurements. The instrument can also perform spatial characterization to detect coating nonuniformity

  3. High accuracy 3D electromagnetic finite element analysis

    International Nuclear Information System (INIS)

    Nelson, E.M.

    1996-01-01

    A high accuracy 3D electromagnetic finite element field solver employing quadratic hexahedral elements and quadratic mixed-order one-form basis functions will be described. The solver is based on an object-oriented C++ class library. Test cases demonstrate that frequency errors less than 10 ppm can be achieved using modest workstations, and that the solutions have no contamination from spurious modes. The role of differential geometry and geometrical physics in finite element analysis will also be discussed

  4. High accuracy 3D electromagnetic finite element analysis

    International Nuclear Information System (INIS)

    Nelson, Eric M.

    1997-01-01

    A high accuracy 3D electromagnetic finite element field solver employing quadratic hexahedral elements and quadratic mixed-order one-form basis functions will be described. The solver is based on an object-oriented C++ class library. Test cases demonstrate that frequency errors less than 10 ppm can be achieved using modest workstations, and that the solutions have no contamination from spurious modes. The role of differential geometry and geometrical physics in finite element analysis will also be discussed

  5. Why is a high accuracy needed in dosimetry

    International Nuclear Information System (INIS)

    Lanzl, L.H.

    1976-01-01

    Dose and exposure intercomparisons on a national or international basis have become an important component of quality assurance in the practice of good radiotherapy. A high degree of accuracy of γ and x radiation dosimetry is essential in our international society, where medical information is so readily exchanged and used. The value of accurate dosimetry lies mainly in the avoidance of complications in normal tissue and an optimal degree of tumor control

  6. Assessing the accuracy of body mass estimation equations from pelvic and femoral variables among modern British women of known mass.

    Science.gov (United States)

    Young, Mariel; Johannesdottir, Fjola; Poole, Ken; Shaw, Colin; Stock, J T

    2018-02-01

    Femoral head diameter is commonly used to estimate body mass from the skeleton. The three most frequently employed methods, designed by Ruff, Grine, and McHenry, were developed using different populations to address different research questions. They were not specifically designed for application to female remains, and their accuracy for this purpose has rarely been assessed or compared in living populations. This study analyzes the accuracy of these methods using a sample of modern British women through the use of pelvic CT scans (n = 97) and corresponding information about the individuals' known height and weight. Results showed that all methods provided reasonably accurate body mass estimates (average percent prediction errors under 20%) for the normal weight and overweight subsamples, but were inaccurate for the obese and underweight subsamples (average percent prediction errors over 20%). When women of all body mass categories were combined, the methods provided reasonable estimates (average percent prediction errors between 16 and 18%). The results demonstrate that different methods provide more accurate results within specific body mass index (BMI) ranges. The McHenry Equation provided the most accurate estimation for women of small body size, while the original Ruff Equation is most likely to be accurate if the individual was obese or severely obese. The refined Ruff Equation was the most accurate predictor of body mass on average for the entire sample, indicating that it should be utilized when there is no knowledge of the individual's body size or if the individual is assumed to be of a normal body size. The study also revealed a correlation between pubis length and body mass, and an equation for body mass estimation using pubis length was accurate in a dummy sample, suggesting that pubis length can also be used to acquire reliable body mass estimates. This has implications for how we interpret body mass in fossil hominins and has particular relevance

  7. Diagnostic Accuracy of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Characterizing Lung Masses

    Science.gov (United States)

    Inan, Nagihan; Arslan, Arzu; Donmez, Muhammed; Sarisoy, Hasan Tahsin

    2016-01-01

    Background Imaging plays a critical role not only in the detection, but also in the characterization of lung masses as benign or malignant. Objectives To determine the diagnostic accuracy of dynamic magnetic resonance imaging (MRI) in the differential diagnosis of benign and malignant lung masses. Patients and Methods Ninety-four masses were included in this prospective study. Five dynamic series of T1-weighted spoiled gradient echo (FFE) images were obtained, followed by a T1-weighted FFE sequence in the late phase (5th minutes). Contrast enhancement patterns in the early (25th second) and late (5th minute) phase images were evaluated. For the quantitative evaluation, signal intensity (SI)-time curves were obtained and the maximum relative enhancement, wash-in rate, and time-to-peak enhancement of masses in both groups were calculated. Results The early phase contrast enhancement patterns were homogeneous in 78.2% of the benign masses, while heterogeneous in 74.4% of the malignant tumors. On the late phase images, 70.8% of the benign masses showed homogeneous enhancement, while most of the malignant masses showed heterogeneous enhancement (82.4%). During the first pass, the maximum relative enhancement and wash-in rate values of malignant masses were significantly higher than those of the benign masses (P = 0.03 and 0.04, respectively). The cutoff value at 15% yielded a sensitivity of 85.4%, specificity of 61.2%, and positive predictive value of 68.7% for the maximum relative enhancement. Conclusion Contrast enhancement patterns and SI-time curve analysis of MRI are helpful in the differential diagnosis of benign and malignant lung masses. PMID:27703654

  8. The Influence of Methods Massed Practice and Distributed Practice Model on The Speed and Accuracy of Service Tennis Courts

    OpenAIRE

    Desak Wiwin,; Edy Mintarto; Nurkholis Nurkholis

    2017-01-01

    The purpose of this study was to analyze about (1) the effect of the method massed practice against the speed and accuracy of service, (2) the effect of the method of distributed practice against the speed and accuracy of service and (3) the influence of methods of massed practice and distributed practice against the speed and accuracy of service. This type of research used in this research is quantitative with quasiexperimental methods. The research design uses a non-randomized control group...

  9. Achieving High Accuracy in Calculations of NMR Parameters

    DEFF Research Database (Denmark)

    Faber, Rasmus

    quantum chemical methods have been developed, the calculation of NMR parameters with quantitative accuracy is far from trivial. In this thesis I address some of the issues that makes accurate calculation of NMR parameters so challenging, with the main focus on SSCCs. High accuracy quantum chemical......, but no programs were available to perform such calculations. As part of this thesis the CFOUR program has therefore been extended to allow the calculation of SSCCs using the CC3 method. CC3 calculations of SSCCs have then been performed for several molecules, including some difficult cases. These results show...... vibrations must be included. The calculation of vibrational corrections to NMR parameters has been reviewed as part of this thesis. A study of the basis set convergence of vibrational corrections to nuclear shielding constants has also been performed. The basis set error in vibrational correction...

  10. Improved mass-measurement accuracy using a PNB Load Cell Scale

    International Nuclear Information System (INIS)

    Suda, S.; Pontius, P.; Schoonover, R.

    1981-08-01

    The PNB Load Cell Scale is a Preloaded, Narrow-Band calibration mass comparator. It consists of (1) a frame and servo-mechanism that maintains a preload tension on the load cell until the load, an unknown mass, is sensed, and (2) a null-balance digital instrument that suppresses the cell response associated with the preload, thereby improving the precision and accuracy of the measurements. Ideally, the objects used to set the preload should be replica mass standards that closely approximate the density and mass of the unknowns. The advantages of the PNB scale are an expanded output signal over the range of interest which increases both the sensitivity and resolution, and minimizes the transient effects associated with loading of load cells. An area of immediate and practical application of this technique to nuclear material safeguards is the weighing of UF 6 cyliners where in-house mass standards are currently available and where the mass values are typically assigned on the basis of comparison weighings. Several prototypical versions of the PNB scale have been assembled at the US National Bureau of Standards. A description of the instrumentation, principles of measurements, and applications are presented in this paper

  11. A high accuracy land use/cover retrieval system

    Directory of Open Access Journals (Sweden)

    Alaa Hefnawy

    2012-03-01

    Full Text Available The effects of spatial resolution on the accuracy of mapping land use/cover types have received increasing attention as a large number of multi-scale earth observation data become available. Although many methods of semi automated image classification of remotely sensed data have been established for improving the accuracy of land use/cover classification during the past 40 years, most of them were employed in single-resolution image classification, which led to unsatisfactory results. In this paper, we propose a multi-resolution fast adaptive content-based retrieval system of satellite images. Through our proposed system, we apply a Super Resolution technique for the Landsat-TM images to have a high resolution dataset. The human–computer interactive system is based on modified radial basis function for retrieval of satellite database images. We apply the backpropagation supervised artificial neural network classifier for both the multi and single resolution datasets. The results show significant improved land use/cover classification accuracy for the multi-resolution approach compared with those from single-resolution approach.

  12. Two high accuracy digital integrators for Rogowski current transducers

    Science.gov (United States)

    Luo, Pan-dian; Li, Hong-bin; Li, Zhen-hua

    2014-01-01

    The Rogowski current transducers have been widely used in AC current measurement, but their accuracy is mainly subject to the analog integrators, which have typical problems such as poor long-term stability and being susceptible to environmental conditions. The digital integrators can be another choice, but they cannot obtain a stable and accurate output for the reason that the DC component in original signal can be accumulated, which will lead to output DC drift. Unknown initial conditions can also result in integral output DC offset. This paper proposes two improved digital integrators used in Rogowski current transducers instead of traditional analog integrators for high measuring accuracy. A proportional-integral-derivative (PID) feedback controller and an attenuation coefficient have been applied in improving the Al-Alaoui integrator to change its DC response and get an ideal frequency response. For the special design in the field of digital signal processing, the improved digital integrators have better performance than analog integrators. Simulation models are built for the purpose of verification and comparison. The experiments prove that the designed integrators can achieve higher accuracy than analog integrators in steady-state response, transient-state response, and temperature changing condition.

  13. High Accuracy Piezoelectric Kinemometer; Cinemometro piezoelectrico de alta exactitud (VUAE)

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez Martinez, F. J.; Frutos, J. de; Pastor, C.; Vazquez Rodriguez, M.

    2012-07-01

    We have developed a portable computerized and low consumption, our system is called High Accuracy Piezoelectric Kinemometer measurement, herein VUAE. By the high accuracy obtained by VUAE it make able to use the VUAE to obtain references measurements of system for measuring Speeds in Vehicles. Therefore VUAE could be used how reference equipment to estimate the error of installed kinemometers. The VUAE was created with n (n=2) pairs of ultrasonic transmitter-receiver, herein E-Rult. The transmitters used in the n couples E-Rult generate n ultrasonic barriers and receivers receive the echoes when the vehicle crosses the barriers. Digital processing of the echoes signals let us to obtain acceptable signals. Later, by mean of cross correlation technics is possible make a highly exact estimation of speed of the vehicle. The log of the moments of interception and the distance between each of the n ultrasounds allows for a highly exact estimation of speed of the vehicle. VUAE speed measurements were compared to a speed reference system based on piezoelectric cables. (Author) 11 refs.

  14. Accuracy of Estimating Highly Eccentric Binary Black Hole Parameters with Gravitational-wave Detections

    Science.gov (United States)

    Gondán, László; Kocsis, Bence; Raffai, Péter; Frei, Zsolt

    2018-03-01

    Mergers of stellar-mass black holes on highly eccentric orbits are among the targets for ground-based gravitational-wave detectors, including LIGO, VIRGO, and KAGRA. These sources may commonly form through gravitational-wave emission in high-velocity dispersion systems or through the secular Kozai–Lidov mechanism in triple systems. Gravitational waves carry information about the binaries’ orbital parameters and source location. Using the Fisher matrix technique, we determine the measurement accuracy with which the LIGO–VIRGO–KAGRA network could measure the source parameters of eccentric binaries using a matched filtering search of the repeated burst and eccentric inspiral phases of the waveform. We account for general relativistic precession and the evolution of the orbital eccentricity and frequency during the inspiral. We find that the signal-to-noise ratio and the parameter measurement accuracy may be significantly higher for eccentric sources than for circular sources. This increase is sensitive to the initial pericenter distance, the initial eccentricity, and the component masses. For instance, compared to a 30 {M}ȯ –30 {M}ȯ non-spinning circular binary, the chirp mass and sky-localization accuracy can improve by a factor of ∼129 (38) and ∼2 (11) for an initially highly eccentric binary assuming an initial pericenter distance of 20 M tot (10 M tot).

  15. Body Mass Index is a Poor Predictor of Bedside Appendix Ultrasound Success or Accuracy

    Science.gov (United States)

    Lam, Samuel H.F.; Kerwin, Christopher; Konicki, P. John; Goodwine, Diana; Lambert, Michael J.

    2016-01-01

    Introduction The objective of this study was to determine whether there is a relationship between body mass index (BMI) and success or accuracy rate of beside ultrasound (BUS) for the diagnosis of appendicitis. Methods Patients four years of age and older presenting to the emergency department with suspected appendicitis were eligible. Enrollment was by convenience sampling. After informed consent, BUS was performed by trained emergency physicians who had undergone a minimum of one-hour didactic training on the use of BUS to diagnose appendicitis. We ascertained subject outcomes by a combination of medical record review and telephone follow up. Calculated BMI for adults and children were divided into four categories (underweight, normal, overweight, obese) according to Centers for Disease Control and Prevention classifications. Results A total of 125 subjects consented for the study, and 116 of them had adequate image data for final analysis. Seventy (60%) of the subjects were children. Prevalence of appendicitis was 39%. Fifty-two (45%) of the BUS studies were diagnostic (successful). Overall accuracy rate was 75%. Analysis by chi-square test or Mann-Whitney U test did not find any significant correlation between BMI category and BUS success. Similarly, there was no significant correlation between BMI category and BUS accuracy. The same conclusion was reached when children and adults were analyzed separately, or when subjects were dichotomized into underweight/normal and overweight/obese categories. Conclusion BMI category alone is a poor predictor of appendix BUS success or accuracy. PMID:27429696

  16. High accuracy 3D electromagnetic finite element analysis

    International Nuclear Information System (INIS)

    Nelson, E.M.

    1997-01-01

    A high accuracy 3D electromagnetic finite element field solver employing quadratic hexahedral elements and quadratic mixed-order one-form basis functions will be described. The solver is based on an object-oriented C++ class library. Test cases demonstrate that frequency errors less than 10 ppm can be achieved using modest workstations, and that the solutions have no contamination from spurious modes. The role of differential geometry and geometrical physics in finite element analysis will also be discussed. copyright 1997 American Institute of Physics

  17. Accuracy of some routine method used in clinical chemistry as judged by isotope dilution-mass spectrometry

    International Nuclear Information System (INIS)

    Bjoerkhem, I.; Bergman, A.; Falk, O.; Kallner, A.; Lantto, O.; Svensson, L.; Akerloef, E.; Blomstrand, R.

    1981-01-01

    Serum from patients was pooled, filtered, dispensed, and frozen. This pooled specimen was used for accuracy control in 64 participating laboratories in Sweden. Mean values (state-of-the-art values) were obtained for creatinine, cholesterol, glucose, urea, uric acid, and cortisol. These values were compared with values obtained with highly accurate reference methods based on isotope dilution-mass spectrometry. Differences were marked in the case of determination of creatinine and cortisol. Concerning the other components, the differences between the state-of-the-art value and the values obtained with the reference methods were negligible. Moreover, the glucose oxidase and the oxime methods for determination of glucose and urea were found to give significantly lower values than the hexokinase and urease methods, respectively. Researchers conclude that methods with a higher degree of accuracy are required for routine determination of creatinine and cortisol

  18. Effects of Different Compression Techniques on Diagnostic Accuracies of Breast Masses on Digitized Mammograms

    International Nuclear Information System (INIS)

    Zhigang Liang; Xiangying Du; Jiabin Liu; Yanhui Yang; Dongdong Rong; Xinyu Y ao; Kuncheng Li

    2008-01-01

    Background: The JPEG 2000 compression technique has recently been introduced into the medical imaging field. It is critical to understand the effects of this technique on the detection of breast masses on digitized images by human observers. Purpose: To evaluate whether lossless and lossy techniques affect the diagnostic results of malignant and benign breast masses on digitized mammograms. Material and Methods: A total of 90 screen-film mammograms including craniocaudal and lateral views obtained from 45 patients were selected by two non-observing radiologists. Of these, 22 cases were benign lesions and 23 cases were malignant. The mammographic films were digitized by a laser film digitizer, and compressed to three levels (lossless and lossy 20:1 and 40:1) using the JPEG 2000 wavelet-based image compression algorithm. Four radiologists with 10-12 years' experience in mammography interpreted the original and compressed images. The time interval was 3 weeks for each reading session. A five-point malignancy scale was used, with a score of 1 corresponding to definitely not a malignant mass, a score of 2 referring to not a malignant mass, a score of 3 meaning possibly a malignant mass, a score of 4 being probably a malignant mass, and a score of 5 interpreted as definitely a malignant mass. The radiologists' performance was evaluated using receiver operating characteristic analysis. Results: The average Az values for all radiologists decreased from 0.8933 for the original uncompressed images to 0.8299 for the images compressed at 40:1. This difference was not statistically significant. The detection accuracy of the original images was better than that of the compressed images, and the Az values decreased with increasing compression ratio. Conclusion: Digitized mammograms compressed at 40:1 could be used to substitute original images in the diagnosis of breast cancer

  19. Read-only high accuracy volume holographic optical correlator

    Science.gov (United States)

    Zhao, Tian; Li, Jingming; Cao, Liangcai; He, Qingsheng; Jin, Guofan

    2011-10-01

    A read-only volume holographic correlator (VHC) is proposed. After the recording of all of the correlation database pages by angular multiplexing, a stand-alone read-only high accuracy VHC will be separated from the VHC recording facilities which include the high-power laser and the angular multiplexing system. The stand-alone VHC has its own low power readout laser and very compact and simple structure. Since there are two lasers that are employed for recording and readout, respectively, the optical alignment tolerance of the laser illumination on the SLM is very sensitive. The twodimensional angular tolerance is analyzed based on the theoretical model of the volume holographic correlator. The experimental demonstration of the proposed read-only VHC is introduced and discussed.

  20. The Influence of Methods Massed Practice and Distributed Practice Model on The Speed and Accuracy of Service Tennis Courts

    Directory of Open Access Journals (Sweden)

    Desak Wiwin,

    2017-06-01

    Full Text Available The purpose of this study was to analyze about (1 the effect of the method massed practice against the speed and accuracy of service, (2 the effect of the method of distributed practice against the speed and accuracy of service and (3 the influence of methods of massed practice and distributed practice against the speed and accuracy of service. This type of research used in this research is quantitative with quasiexperimental methods. The research design uses a non-randomized control group pretest posttest design, and data analysis using Manova. The process of data collection is done by testing the speed of service (dartfish and test accuracy (Hewitt during the pretest and posttest. The results of the study as follows: (1 there is a significant influence on the methods of massed practice to increase the speed and accuracy of service (2 there is a significant influence on the method of distributed practice to increase the speed and accuracy of service (3 There is no significant difference influence among methods massed ptactice practice and distributed to the speed and accuracy of service. Conclusions of this research is a method massed practice and distributed practice equally provide significant results but that gives the influence of better is method distributed practice to speed and accuracy of service.

  1. Automated data processing of high-resolution mass spectra

    DEFF Research Database (Denmark)

    Hansen, Michael Adsetts Edberg; Smedsgaard, Jørn

    of the massive amounts of data. We present an automated data processing method to quantitatively compare large numbers of spectra from the analysis of complex mixtures, exploiting the full quality of high-resolution mass spectra. By projecting all detected ions - within defined intervals on both the time...... infusion of crude extracts into the source taking advantage of the high sensitivity, high mass resolution and accuracy and the limited fragmentation. Unfortunately, there has not been a comparable development in the data processing techniques to fully exploit gain in high resolution and accuracy...... infusion analyses of crude extract to find the relationship between species from several species terverticillate Penicillium, and also that the ions responsible for the segregation can be identified. Furthermore the process can automate the process of detecting unique species and unique metabolites....

  2. Original Research Body Mass Index is a Poor Predictor of Bedside Appendix Ultrasound Success or Accuracy

    Directory of Open Access Journals (Sweden)

    Samuel H.F. Lam

    2016-06-01

    Full Text Available Introduction: The objective of this study was to determine whether there is a relationship between body mass index (BMI and success or accuracy rate of beside ultrasound (BUS for the diagnosis of appendicitis. Methods: Patients four years of age and older presenting to the emergency department with suspected appendicitis were eligible. Enrollment was by convenience sampling. After informed consent, BUS was performed by trained emergency physicians who had undergone a minimum of one-hour didactic training on the use of BUS to diagnose appendicitis. We ascertained subject outcomes by a combination of medical record review and telephone follow up. Calculated BMI for adults and children were divided into four categories (underweight, normal, overweight, obese according to Centers for Disease Control and Prevention classifications. Results: A total of 125 subjects consented for the study, and 116 of them had adequate image data for final analysis. Seventy (60% of the subjects were children. Prevalence of appendicitis was 39%. Fifty-two (45% of the BUS studies were diagnostic (successful. Overall accuracy rate was 75%. Analysis by chi-square test or Mann-Whitney U test did not find any significant correlation between BMI category and BUS success. Similarly, there was no significant correlation between BMI category and BUS accuracy. The same conclusion was reached when children and adults were analyzed separately, or when subjects were dichotomized into underweight/ normal and overweight/ obese categories. Conclusion: BMI category alone is a poor predictor of appendix BUS success or accuracy. [West J Emerg Med. 2016;17(4454-459.

  3. Synchrotron accelerator technology for proton beam therapy with high accuracy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo

    2009-01-01

    Proton beam therapy was applied at the beginning to head and neck cancers, but it is now extended to prostate, lung and liver cancers. Thus the need for a pencil beam scanning method is increasing. With this method radiation dose concentration property of the proton beam will be further intensified. Hitachi group has supplied a pencil beam scanning therapy system as the first one for M. D. Anderson Hospital in United States, and it has been operational since May 2008. Hitachi group has been developing proton therapy system to correspond high-accuracy proton therapy to concentrate the dose in the diseased part which is located with various depths, and which sometimes has complicated shape. The author described here on the synchrotron accelerator technology that is an important element for constituting the proton therapy system. (K.Y.)

  4. Instruction manual for ORNL tandem high abundance sensitivity mass spectrometer

    International Nuclear Information System (INIS)

    Smith, D.H.; McKown, H.S.; Chrisite, W.H.; Walker, R.L.; Carter, J.A.

    1976-06-01

    This manual describes the physical characteristics of the tandem mass spectrometer built by Oak Ridge National Laboratory for the International Atomic Energy Agency. Specific requirements met include ability to run small samples, high abundance sensitivity, good precision and accuracy, and adequate sample throughput. The instrument is capable of running uranium samples as small as 10 -12 g and has an abundance sensitivity in excess of 10 6 . Precision and accuracy are enhanced by a special sweep control circuit. Sample throughput is 6 to 12 samples per day. Operating instructions are also given

  5. High accuracy mantle convection simulation through modern numerical methods

    KAUST Repository

    Kronbichler, Martin

    2012-08-21

    Numerical simulation of the processes in the Earth\\'s mantle is a key piece in understanding its dynamics, composition, history and interaction with the lithosphere and the Earth\\'s core. However, doing so presents many practical difficulties related to the numerical methods that can accurately represent these processes at relevant scales. This paper presents an overview of the state of the art in algorithms for high-Rayleigh number flows such as those in the Earth\\'s mantle, and discusses their implementation in the Open Source code Aspect (Advanced Solver for Problems in Earth\\'s ConvecTion). Specifically, we show how an interconnected set of methods for adaptive mesh refinement (AMR), higher order spatial and temporal discretizations, advection stabilization and efficient linear solvers can provide high accuracy at a numerical cost unachievable with traditional methods, and how these methods can be designed in a way so that they scale to large numbers of processors on compute clusters. Aspect relies on the numerical software packages deal.II and Trilinos, enabling us to focus on high level code and keeping our implementation compact. We present results from validation tests using widely used benchmarks for our code, as well as scaling results from parallel runs. © 2012 The Authors Geophysical Journal International © 2012 RAS.

  6. The accuracy of body mass prediction for elderly specimens: Implications for paleoanthropology and legal medicine.

    Science.gov (United States)

    Chevalier, Tony; Lefèvre, Philippe; Clarys, Jan Pieter; Beauthier, Jean-Pol

    2016-10-01

    Different practices in paleoanthropology and legal medicine raise questions concerning the robustness of body mass (BM) prediction. Integrating personal identification from body mass estimation with skeleton is not a classic approach in legal medicine. The originality of our study is the use of an elderly sample in order to push prediction methods to their limits and to discuss about implications in paleoanthropology and legal medicine. The aim is to observe the accuracy of BM prediction in relation to the body mass index (BMI, index of classification) using five femoral head (FH) methods and one shaft (FSH) method. The sample is composed of 41 dry femurs obtained from dissection where age (c. 82 years) and gender are known, and weight (c. 59.5 kg) and height are measured upon admission to the body leg service. We show that the estimation of the mean BM of the elderly sample is not significantly different to the real mean BM when the appropriate formula is used for the femoral head diameter. In fact, the best prediction is obtained with the McHenry formula (1992), which was based on a sample with an equivalent average mass to that of our sample. In comparison, external shaft diameters, which are known to be more influenced by mechanical stimuli than femoral head diameters, yield less satisfactory results with the McHenry formula (1992) for shaft diameters. Based on all the methods used and the distinctive selected sample, overestimation (always observed with the different femoral head methods) can be restricted to 1.1%. The observed overestimation with the shaft method can be restricted to 7%. However, the estimation of individual BM is much less reliable. The BMI has a strong impact on the accuracy of individual BM prediction, and is unquestionably more reliable for individuals with normal BMI (9.6% vs 16.7% for the best prediction error). In this case, the FH method is also the better predictive method but not if we integrate the total sample (i.e., the FSH

  7. Accuracy assessment of high-rate GPS measurements for seismology

    Science.gov (United States)

    Elosegui, P.; Davis, J. L.; Ekström, G.

    2007-12-01

    Analysis of GPS measurements with a controlled laboratory system, built to simulate the ground motions caused by tectonic earthquakes and other transient geophysical signals such as glacial earthquakes, enables us to assess the technique of high-rate GPS. The root-mean-square (rms) position error of this system when undergoing realistic simulated seismic motions is 0.05~mm, with maximum position errors of 0.1~mm, thus providing "ground truth" GPS displacements. We have acquired an extensive set of high-rate GPS measurements while inducing seismic motions on a GPS antenna mounted on this system with a temporal spectrum similar to real seismic events. We found that, for a particular 15-min-long test event, the rms error of the 1-Hz GPS position estimates was 2.5~mm, with maximum position errors of 10~mm, and the error spectrum of the GPS estimates was approximately flicker noise. These results may however represent a best-case scenario since they were obtained over a short (~10~m) baseline, thereby greatly mitigating baseline-dependent errors, and when the number and distribution of satellites on the sky was good. For example, we have determined that the rms error can increase by a factor of 2--3 as the GPS constellation changes throughout the day, with an average value of 3.5~mm for eight identical, hourly-spaced, consecutive test events. The rms error also increases with increasing baseline, as one would expect, with an average rms error for a ~1400~km baseline of 9~mm. We will present an assessment of the accuracy of high-rate GPS based on these measurements, discuss the implications of this study for seismology, and describe new applications in glaciology.

  8. C-arm cone-beam CT virtual navigation-guided percutaneous mediastinal mass biopsy: Diagnostic accuracy and complications

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyungjin [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Aerospace Medical Group, Air Force Education and Training Command, Jinju (Korea, Republic of); Park, Chang Min; Goo, Jin Mo [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Seoul National University, Cancer Research Institute, Seoul (Korea, Republic of); Lee, Sang Min [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of)

    2015-12-15

    To assess the usefulness of C-arm cone-beam computed tomography (CBCT) virtual navigation-guided percutaneous mediastinal mass biopsy in terms of diagnostic accuracy and complication rates. Seventy-eight CBCT virtual navigation-guided percutaneous mediastinal mass biopsies were performed in 75 patients (M:F, 38:37; mean age, 48.55 ± 18.76 years). The procedural details, diagnostic sensitivity, specificity, accuracy and complication rate were investigated. Mean lesion size was 6.80 ± 3.08 cm, skin-to-target distance was 3.67 ± 1.80 cm, core needle biopsy rate was 96.2 % (75/78), needle indwelling time was 9.29 ± 4.34 min, total procedure time was 13.26 ± 5.29 min, number of biopsy specimens obtained was 3.13 ± 1.02, number of CBCTs performed was 3.03 ± 0.68, rate of lesion border discrimination from abutting mediastinal structures on CBCT was 26.9 % (21/78), technical success rate was 100 % (78/78), estimated effective dose was 5.33 ± 4.99 mSv, and the dose area product was 12,723.68 ± 10,665.74 mGy.cm{sup 2}. Among the 78 biopsies, 69 were malignant, 7 were benign and 2 were indeterminate. Diagnostic sensitivity, specificity and accuracy for the diagnosis of malignancies were 97.1 % (67/69), 100 % (7/7) and 97.4 % (74/76), respectively, with a complication rate of 3.85 % (3/78), all of which were small pneumothoraces. CBCT virtual navigation-guided biopsy is a highly accurate and safe procedure for the evaluation of mediastinal lesions. (orig.)

  9. Accuracy assessment of cadastral maps using high resolution aerial photos

    Directory of Open Access Journals (Sweden)

    Alwan Imzahim

    2018-01-01

    Full Text Available A cadastral map is a map that shows the boundaries and ownership of land parcels. Some cadastral maps show additional details, such as survey district names, unique identifying numbers for parcels, certificate of title numbers, positions of existing structures, section or lot numbers and their respective areas, adjoining and adjacent street names, selected boundary dimensions and references to prior maps. In Iraq / Baghdad Governorate, the main problem is that the cadastral maps are georeferenced to a local geodetic datum known as Clark 1880 while the widely used reference system for navigation purpose (GPS and GNSS and uses Word Geodetic System 1984 (WGS84 as a base reference datum. The objective of this paper is to produce a cadastral map with scale 1:500 (metric scale by using aerial photographs 2009 with high ground spatial resolution 10 cm reference WGS84 system. The accuracy assessment for the cadastral maps updating approach to urban large scale cadastral maps (1:500-1:1000 was ± 0.115 meters; which complies with the American Social for Photogrammetry and Remote Sensing Standards (ASPRS.

  10. Determination of UAV position using high accuracy navigation platform

    Directory of Open Access Journals (Sweden)

    Ireneusz Kubicki

    2016-07-01

    Full Text Available The choice of navigation system for mini UAV is very important because of its application and exploitation, particularly when the installed on it a synthetic aperture radar requires highly precise information about an object’s position. The presented exemplary solution of such a system draws attention to the possible problems associated with the use of appropriate technology, sensors, and devices or with a complete navigation system. The position and spatial orientation errors of the measurement platform influence on the obtained SAR imaging. Both, turbulences and maneuvers performed during flight cause the changes in the position of the airborne object resulting in deterioration or lack of images from SAR. Consequently, it is necessary to perform operations for reducing or eliminating the impact of the sensors’ errors on the UAV position accuracy. You need to look for compromise solutions between newer better technologies and in the field of software. Keywords: navigation systems, unmanned aerial vehicles, sensors integration

  11. Double Beta Decay and Neutrino Masses Accuracy of the Nuclear Matrix Elements

    International Nuclear Information System (INIS)

    Faessler, Amand

    2005-01-01

    The neutrinoless double beta decay is forbidden in the standard model of the electroweak and strong interaction but allowed in most Grand Unified Theories (GUT's). Only if the neutrino is a Majorana particle (identical with its antiparticle) and if it has a mass, the neutrinoless double beta decay is allowed. Apart of one claim that the neutrinoless double beta decay in 76 Ge is measured, one has only upper limits for this transition probability. But even the upper limits allow to give upper limits for the electron Majorana neutrino mass and upper limits for parameters of GUT's and the minimal R-parity violating supersymmetric model. One further can give lower limits for the vector boson mediating mainly the right-handed weak interaction and the heavy mainly right-handed Majorana neutrino in left-right symmetric GUT's. For that one has to assume that the specific mechanism is the leading one for the neutrinoless double beta decay and one has to be able to calculate reliably the corresponding nuclear matrix elements. In the present contribution, one discusses the accuracy of the present status of calculating the nuclear matrix elements and the corresponding limits of GUT's and supersymmetric parameters

  12. Modified sine bar device measures small angles with high accuracy

    Science.gov (United States)

    Thekaekara, M.

    1968-01-01

    Modified sine bar device measures small angles with enough accuracy to calibrate precision optical autocollimators. The sine bar is a massive bar of steel supported by two cylindrical rods at one end and one at the other.

  13. Measurement system with high accuracy for laser beam quality.

    Science.gov (United States)

    Ke, Yi; Zeng, Ciling; Xie, Peiyuan; Jiang, Qingshan; Liang, Ke; Yang, Zhenyu; Zhao, Ming

    2015-05-20

    Presently, most of the laser beam quality measurement system collimates the optical path manually with low efficiency and low repeatability. To solve these problems, this paper proposed a new collimated method to improve the reliability and accuracy of the measurement results. The system accuracy controlled the position of the mirror to change laser beam propagation direction, which can realize the beam perpendicularly incident to the photosurface of camera. The experiment results show that the proposed system has good repeatability and the measuring deviation of M2 factor is less than 0.6%.

  14. Accuracy of Plantar Electrodes Compared with Hand and Foot Electrodes in Fat-free-mass Measurement

    Directory of Open Access Journals (Sweden)

    Michel Y. Jaffrin

    2014-01-01

    Full Text Available This paper investigates the measurement of fat-free mass (FFM by bioimpedance using foot-to-foot impedancemeters (FFI with plantar electrodes measuring the foot-to-foot resistance R34 and hand-to-foot medical impedancemeters. FFM measurements were compared with corresponding data using Dual X-ray absorptiometry (DXA. Equations giving FFM were established using linear multiple regression on DXA data in a first group of 170 subjects. For validation, these equations were used on a second group of 86 subjects, and FFM were compared with DXA data; no significant difference was observed. The same protocol was repeated, but using electrodes on the right hand and foot in standing position to measure the hand to-foot resistance R13. Mean differences with DXA were higher for R13 than for R34. Effect of electrode size and feet position on resistance was also investigated. R34 decreased when electrode area increased or if feet were moved forward. It decreased if feet were moved backward. A proper configuration of contact electrodes can improve measurement accuracy and reproducibility of FFI.

  15. Diagnostic accuracy of high-definition CT coronary angiography in high-risk patients

    International Nuclear Information System (INIS)

    Iyengar, S.S.; Morgan-Hughes, G.; Ukoumunne, O.; Clayton, B.; Davies, E.J.; Nikolaou, V.; Hyde, C.J.; Shore, A.C.; Roobottom, C.A.

    2016-01-01

    Aim: To assess the diagnostic accuracy of computed tomography coronary angiography (CTCA) using a combination of high-definition CT (HD-CTCA) and high level of reader experience, with invasive coronary angiography (ICA) as the reference standard, in high-risk patients for the investigation of coronary artery disease (CAD). Materials and methods: Three hundred high-risk patients underwent HD-CTCA and ICA. Independent experts evaluated the images for the presence of significant CAD, defined primarily as the presence of moderate (≥50%) stenosis and secondarily as the presence of severe (≥70%) stenosis in at least one coronary segment, in a blinded fashion. HD-CTCA was compared to ICA as the reference standard. Results: No patients were excluded. Two hundred and six patients (69%) had moderate and 178 (59%) had severe stenosis in at least one vessel at ICA. The sensitivity, specificity, positive predictive value, and negative predictive value were 97.1%, 97.9%, 99% and 93.9% for moderate stenosis, and 98.9%, 93.4%, 95.7% and 98.3%, for severe stenosis, on a per-patient basis. Conclusion: The combination of HD-CTCA and experienced readers applied to a high-risk population, results in high diagnostic accuracy comparable to ICA. Modern generation CT systems in experienced hands might be considered for an expanded role. - Highlights: • Diagnostic accuracy of High-Definition CT Angiography (HD-CTCA) has been assessed. • Invasive Coronary angiography (ICA) is the reference standard. • Diagnostic accuracy of HD-CTCA is comparable to ICA. • Diagnostic accuracy is not affected by coronary calcium or stents. • HD-CTCA provides a non-invasive alternative in high-risk patients.

  16. A new device for liver cancer biomarker detection with high accuracy

    Directory of Open Access Journals (Sweden)

    Shuaipeng Wang

    2015-06-01

    Full Text Available A novel cantilever array-based bio-sensor was batch-fabricated with IC compatible MEMS technology for precise liver cancer bio-marker detection. A micro-cavity was designed in the free end of the cantilever for local antibody-immobilization, thus adsorption of the cancer biomarker is localized in the micro-cavity, and the adsorption-induced k variation can be dramatically reduced with comparison to that caused by adsorption of the whole lever. The cantilever is pizeoelectrically driven into vibration which is pizeoresistively sensed by Wheatstone bridge. These structural features offer several advantages: high sensitivity, high throughput, high mass detection accuracy, and small volume. In addition, an analytical model has been established to eliminate the effect of adsorption-induced lever stiffness change and has been applied to precise mass detection of cancer biomarker AFP, the detected AFP antigen mass (7.6 pg/ml is quite close to the calculated one (5.5 pg/ml, two orders of magnitude better than the value by the fully antibody-immobilized cantilever sensor. These approaches will promote real application of the cantilever sensors in early diagnosis of cancer.

  17. High-accuracy user identification using EEG biometrics.

    Science.gov (United States)

    Koike-Akino, Toshiaki; Mahajan, Ruhi; Marks, Tim K; Ye Wang; Watanabe, Shinji; Tuzel, Oncel; Orlik, Philip

    2016-08-01

    We analyze brain waves acquired through a consumer-grade EEG device to investigate its capabilities for user identification and authentication. First, we show the statistical significance of the P300 component in event-related potential (ERP) data from 14-channel EEGs across 25 subjects. We then apply a variety of machine learning techniques, comparing the user identification performance of various different combinations of a dimensionality reduction technique followed by a classification algorithm. Experimental results show that an identification accuracy of 72% can be achieved using only a single 800 ms ERP epoch. In addition, we demonstrate that the user identification accuracy can be significantly improved to more than 96.7% by joint classification of multiple epochs.

  18. Methodology for GPS Synchronization Evaluation with High Accuracy

    OpenAIRE

    Li Zan; Braun Torsten; Dimitrova Desislava

    2015-01-01

    Clock synchronization in the order of nanoseconds is one of the critical factors for time based localization. Currently used time synchronization methods are developed for the more relaxed needs of network operation. Their usability for positioning should be carefully evaluated. In this paper we are particularly interested in GPS based time synchronization. To judge its usability for localization we need a method that can evaluate the achieved time synchronization with nanosecond accuracy. Ou...

  19. Methodology for GPS Synchronization Evaluation with High Accuracy

    OpenAIRE

    Li, Zan; Braun, Torsten; Dimitrova, Desislava Cvetanova

    2015-01-01

    Clock synchronization in the order of nanoseconds is one of the critical factors for time-based localization. Currently used time synchronization methods are developed for the more relaxed needs of network operation. Their usability for positioning should be carefully evaluated. In this paper, we are particularly interested in GPS-based time synchronization. To judge its usability for localization we need a method that can evaluate the achieved time synchronization with nanosecond accuracy. O...

  20. Accuracy of immunoassay and mass spectrometry urinary free cortisol in the diagnosis of Cushing's syndrome.

    Science.gov (United States)

    Aranda, G; Careaga, M; Hanzu, F A; Patrascioiu, I; Ríos, P; Mora, M; Morales-Romero, B; Jiménez, W; Halperin, I; Casals, G

    2016-10-01

    Urinary free cortisol (UFC) determination by highly specific methods as mass spectrometry instead of commercially available antibody-based immunoassays is increasingly recommended. However, clinical comparisons of both analytical approaches in the screening of Cushing's syndrome (CS) are not available. The aim of this study was to evaluate the diagnostic value of mass spectrometry versus immunoassay measurements of 24 h-UFC in the screening of CS. Cross-sectional study of 33 histologically confirmed CS patients: 25 Cushing's disease, 5 adrenal CS and 3 ectopic CS; 92 non-CS patients; and 35 healthy controls. UFC by immunoassay (UFCxIA) and mass spectrometry (UFCxMS), urinary free cortisone (UFCo) and UFC:UFCo ratio were measured, together with creatinine-corrected values. Sensitivity, specificity, AUC and Landis and Koch concordance index were determined. AUC for UFCxIA and UFCxMS were 0.77 (CI 0.68-0.87) and 0.77 (CI 0.67-0.87) respectively, with a kappa coefficient 0.60 and strong Landis and Koch concordance index. The best calculated cutoff values were 359 nmol/24 h for UFCxIA (78 % sensitivity, 62 % specificity) and 258.1 nmol/24 h for UCFxMS (53 % sensitivity, 86 % specificity). The upper limit of UFCxIA and UCFxMS reference ranges were 344.7 and 169.5 nmol/24 h respectively. Sensitivity and specificity for CS diagnosis at these cutpoints were 84 and 56 % for UFCxIA and 81 and 54 % for UFCxMS. According to our data, both methods present a very similar diagnostic value. However, results suggest that lower cutoff points for mass spectrometry may be necessary in order to improve clinical sensitivity.

  1. Comparison of Diagnostic Accuracy of Breast Masses Using Digitized Images Versus Screen-Film Mammography

    International Nuclear Information System (INIS)

    Zhigang Liang; Xiangying Du; Jiabin Liu; Xinyu Yao; Yanhui Yang; Kuncheng Li

    2008-01-01

    Background: Medical film digitizers play an important transitory role as digital-analogue bridges in radiology. Digitized mammograms require evaluation of performance to assure medical image quality. Purpose: To compare the diagnostic accuracy in the interpretation of breast masses using original screen-film mammograms versus digitized images. Material and Methods: A total of 72 female patients between 55 and 81 years of age suspected of having breast cancer were selected by two non-observing radiologists. Of these, 31 cases were benign lesions and 41 cases were cancer. The mammography films were digitized using a laser film digitizer. Three radiologists, each with more than 10 years of experience in mammography, interpreted the screen-film mammograms and digitized images respectively. The time interval was 4 weeks. A four-point malignancy scale was used, with 1 defined as definitely not malignant, 2 as probably not malignant, 3 as probably malignant, and 4 as definitely malignant. Receiver operating characteristic (Roc) curves, sensitivity, and specificity were compared. Results: The average area-under-the-curve (Az) value of the original screen-film mammograms was 0.921, and the average Az value of the digitized images was 0.859. This difference was not statistically significant (P=0.131). The detection specificity of extremely dense breasts was lower than that for other breast compositions for both digitized images and screen-film mammograms. No statistical significance in sensitivity and specificity was observed between digitized images and mammograms for each breast composition. Original screen-film mammograms were observed to perform better than digitized images. Conclusion: Digitized images with a spatial resolution of 175 μm can be used instead of screen-film mammograms in the diagnosis of breast cancer

  2. Highly multiparametric analysis by mass cytometry.

    Science.gov (United States)

    Ornatsky, Olga; Bandura, Dmitry; Baranov, Vladimir; Nitz, Mark; Winnik, Mitchell A; Tanner, Scott

    2010-09-30

    This review paper describes a new technology, mass cytometry, that addresses applications typically run by flow cytometer analyzers, but extends the capability to highly multiparametric analysis. The detection technology is based on atomic mass spectrometry. It offers quantitation, specificity and dynamic range of mass spectrometry in a format that is familiar to flow cytometry practitioners. The mass cytometer does not require compensation, allowing the application of statistical techniques; this has been impossible given the constraints of fluorescence noise with traditional cytometry instruments. Instead of "colors" the mass cytometer "reads" the stable isotope tags attached to antibodies using metal-chelating labeling reagents. Because there are many available stable isotopes, and the mass spectrometer provides exquisite resolution between detection channels, many parameters can be measured as easily as one. For example, in a single tube the technique allows for the ready detection and characterization of the major cell subsets in blood or bone marrow. Here we describe mass cytometric immunophenotyping of human leukemia cell lines and leukemia patient samples, differential cell analysis of normal peripheral and umbilical cord blood; intracellular protein identification and metal-encoded bead arrays. Copyright © 2010 Elsevier B.V. All rights reserved.

  3. Vector Boson Scattering at High Mass

    CERN Document Server

    Sherwood, P

    2009-01-01

    In the absence of a light Higgs boson, the mechanism of electroweak symmetry breaking will be best studied in processes of vector boson scattering at high mass. Various models predict resonances in this channel. Here, we investigate W W scalar and vector resonances, W Z vector resonances and a Z Z scalar resonance over a range of diboson centre-of-mass energies. Particular attention is paid to the application reconstruction of dijet pairs with low opening angle resulting from the decay of highly boosted vector bosons.

  4. High-Precision Direct Mass Determination of Unstable Isotopes

    CERN Multimedia

    2002-01-01

    The extension of systematic high-precision measurements of the nuclear mass to nuclei far from the valley of $\\beta$ stability is of great interest in nuclear physics and astrophysics. The mass, or binding energy, is a fundamental gross property and a key input parameter for nuclear matter calculations. It is also a sensitive probe for collective and single-particle effects in nuclear structure. \\\\ \\\\ For such purposes, nuclear masses need to be known to an accuracy of about 10$^{-7}$ (i.e. $\\Delta$M~$\\leq$~10~keV for A~=~100). To resolve a particular mass from its nuclear isomers and isobars, resolving power of 10$^6$ are often required. To achieve this, the ions delivered by the on-line mass separator ISOLDE are confined in a Penning quadrupole trap. This trap is placed in the very homogeneous and stable magnetic field of a superconducting magnet. Here, the cyclotron frequency and hence the mass are determined. \\\\ \\\\ The first measurements using this new technique have been completed for a long chain of Cs ...

  5. Research on Horizontal Accuracy Method of High Spatial Resolution Remotely Sensed Orthophoto Image

    Science.gov (United States)

    Xu, Y. M.; Zhang, J. X.; Yu, F.; Dong, S.

    2018-04-01

    At present, in the inspection and acceptance of high spatial resolution remotly sensed orthophoto image, the horizontal accuracy detection is testing and evaluating the accuracy of images, which mostly based on a set of testing points with the same accuracy and reliability. However, it is difficult to get a set of testing points with the same accuracy and reliability in the areas where the field measurement is difficult and the reference data with high accuracy is not enough. So it is difficult to test and evaluate the horizontal accuracy of the orthophoto image. The uncertainty of the horizontal accuracy has become a bottleneck for the application of satellite borne high-resolution remote sensing image and the scope of service expansion. Therefore, this paper proposes a new method to test the horizontal accuracy of orthophoto image. This method using the testing points with different accuracy and reliability. These points' source is high accuracy reference data and field measurement. The new method solves the horizontal accuracy detection of the orthophoto image in the difficult areas and provides the basis for providing reliable orthophoto images to the users.

  6. Combine body mass index and body fat percentage measures to improve the accuracy of obesity screening in young adults.

    Science.gov (United States)

    Hung, Shang-Ping; Chen, Ching-Yu; Guo, Fei-Ran; Chang, Ching-I; Jan, Chyi-Feng

    Obesity screening among young adult groups is meaningful. Body mass index (BMI) is limited to discriminate between fat and lean mass. Asian young adult group tends to have lower BMI and higher body fat percentage (BFP) than other ethnic groups. Accuracy of obesity screening by commonly used BMI criteria is unclear in young Taiwanese population. A total of 894 young adults (447 males and 447 females) aged 20-26 were recruited. BMI, regional fat percentage and BFP determined by bioelectrical impedance analysis (BIA) were measured. BMI cutoff points were based on the criteria adopted by the Ministry of Health and Welfare in Taiwan. Cutoff points of low or high BFP were defined as 24% in men and 31.4% in women. Prevalence of BFP defining obesity was 14.8% in young men and 27.3% in young women. 23.2% of young men and only 8.3% of young women were classified to overweight or obesity categories according to the BMI criteria. Disagreement was noticed mainly among overweight males and normal weight females. 68.7% of BMI defining overweight young men had low BFP; however, 29.7% of young women of BMI defining normal group had high BFP. Up to 69.7% of young women with high BFP would be missed by BMI category only. Disagreement between BMI and BFP was significant among young adults, especially young women. We suggest combining BMI and BIA for obesity and overweight screening in Asian young adults. Copyright © 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

  7. Innovative Fiber-Optic Gyroscopes (FOGs) for High Accuracy Space Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA's future science and exploratory missions will require much lighter, smaller, and longer life rate sensors that can provide high accuracy navigational...

  8. High Accuracy Positioning using Jet Thrusters for Quadcopter

    Directory of Open Access Journals (Sweden)

    Pi ChenHuan

    2018-01-01

    Full Text Available A quadcopter is equipped with four additional jet thrusters on its horizontal plane and vertical to each other in order to improve the maneuverability and positioning accuracy of quadcopter. A dynamic model of the quadcopter with jet thrusters is derived and two controllers are implemented in simulation, one is a dual loop state feedback controller for pose control and another is an auxiliary jet thruster controller for accurate positioning. Step response simulations showed that the jet thruster can control the quadcopter with less overshoot compared to the conventional one. Over 10s loiter simulation with disturbance, the quadcopter with jet thruster decrease 85% of RMS error of horizontal disturbance compared to a conventional quadcopter with only a dual loop state feedback controller. The jet thruster controller shows the possibility for further accurate in the field of quadcopter positioning.

  9. High-accuracy contouring using projection moiré

    Science.gov (United States)

    Sciammarella, Cesar A.; Lamberti, Luciano; Sciammarella, Federico M.

    2005-09-01

    Shadow and projection moiré are the oldest forms of moiré to be used in actual technical applications. In spite of this fact and the extensive number of papers that have been published on this topic, the use of shadow moiré as an accurate tool that can compete with alternative devices poses very many problems that go to the very essence of the mathematical models used to obtain contour information from fringe pattern data. In this paper some recent developments on the projection moiré method are presented. Comparisons between the results obtained with the projection method and the results obtained by mechanical devices that operate with contact probes are presented. These results show that the use of projection moiré makes it possible to achieve the same accuracy that current mechanical touch probe devices can provide.

  10. Aluminum nanocantilevers for high sensitivity mass sensors

    DEFF Research Database (Denmark)

    Davis, Zachary James; Boisen, Anja

    2005-01-01

    We have fabricated Al nanocantilevers using a simple, one mask contact UV lithography technique with lateral and vertical dimensions under 500 and 100 nm, respectively. These devices are demonstrated as highly sensitive mass sensors by measuring their dynamic properties. Furthermore, it is shown ...

  11. Influence of the velocity vector base relocation to the center of mass of the interrogation area on PIV accuracy

    Directory of Open Access Journals (Sweden)

    Kouba Jan

    2014-03-01

    Full Text Available This paper is aimed at modification of calculation algorithm used in data processing from PIV (Particle Image Velocimetry method. The modification of standard Multi-step correlation algorithm is based on imaging the centre of mass of the interrogation area to define the initial point of the respective vector, instead of the geometrical centre. This paper describes the principle of initial point-vector assignment, the corresponding data processing methodology including the test track analysis. Both approaches are compared within the framework of accuracy in the conclusion. The accuracy test is performed using synthetic and real data.

  12. Evaluation of bilirubin interference and accuracy of six creatinine assays compared with isotope dilution-liquid chromatography mass spectrometry.

    Science.gov (United States)

    Nah, Hyunjin; Lee, Sang-Guk; Lee, Kyeong-Seob; Won, Jae-Hee; Kim, Hyun Ok; Kim, Jeong-Ho

    2016-02-01

    The aim of this study was to estimate bilirubin interference and accuracy of six routine methods for measuring creatinine compared with isotope dilution-liquid chromatography mass spectrometry (ID-LC/MS). A total of 40 clinical serum samples from 31 patients with serum total bilirubin concentration >68.4μmol/L were collected. Serum creatinine was measured using two enzymatic reagents and four Jaffe reagents as well as ID-LC/MS. Correlations between bilirubin concentration and percent difference in creatinine compared with ID-LC/MS were analyzed to investigate bilirubin interference. Bias estimations between the six reagents and ID-LC/MS were performed. Recovery tests using National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 967a were also performed. Both the enzymatic methods showed no bilirubin interference. However, three of the four Jaffe methods demonstrated significant bilirubin concentration-dependent interference in samples with creatinine levels creatinine levels ranging from 53.0 to 97.2μmol/L. Comparison of these methods with ID-LC/MS using patients' samples with elevated bilirubin revealed that the tested methods failed to achieve the bias goal at especially low levels of creatinine. In addition, recovery test using NIST SRM 967a showed that bias in one Jaffe method and two enzymatic methods did not achieve the bias goal at either low or high level of creatinine, indicating they had calibration bias. One enzymatic method failed to achieve all the bias goals in both comparison experiment and recovery test. It is important to understand that both bilirubin interference and calibration traceability to ID-LC/MS should be considered to improve the accuracy of creatinine measurement. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  13. Uncertainty analysis in Titan ionospheric simulated ion mass spectra: unveiling a set of issues for models accuracy improvement

    Science.gov (United States)

    Hébrard, Eric; Carrasco, Nathalie; Dobrijevic, Michel; Pernot, Pascal

    Ion Neutral Mass Spectrometer (INMS) aboard Cassini revealed a rich coupled ion-neutral chemistry in the ionosphere, producing heavy hydrocarbons and nitriles ions. The modeling of such a complex environment is challenging, as it requires a detailed and accurate description of the different relevant processes such as photodissociation cross sections and neutral-neutral reaction rates on one hand, and ionisation cross sections, ion-molecule and recombination reaction rates on the other hand. Underpinning models calculations, each of these processes is parameterized by kinetic constants which, when known, have been studied experimentally and/or theoretically over a range of temperatures and pressures that are most often not representative of Titan's atmosphere. The sizeable experimental and theoretical uncertainties reported in the literature merge therefore with the uncertainties resulting subsequently from the unavoidable estimations or extrapolations to Titan's atmosphere conditions. Such large overall uncertainties have to be accounted for in all resulting inferences most of all to evaluate the quality of the model definition. We have undertaken a systematic study of the uncertainty sources in the simulation of ion mass spectra as recorded by Cassini/INMS in Titan ionosphere during the T5 flyby at 1200 km. Our simulated spectra seem much less affected by the uncertainties on ion-molecule reactions than on neutral-neutral reactions. Photochemical models of Titan's atmosphere are indeed so poorly predictive at high altitudes, in the sense that their computed predictions display such large uncertainties, that we found them to give rise to bimodal and hypersensitive abundance distributions for some major compounds like acetylene C2 H2 and ethylene C2 H4 . We will show to what extent global uncertainty and sensitivity analysis enabled us to identify the causes of this bimodality and to pinpoint the key processes that mostly contribute to limit the accuracy of the

  14. Compact, High Accuracy CO2 Monitor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase I proposal seeks to develop a low cost, robust, highly precise and accurate CO2 monitoring system. This system will...

  15. Compact, High Accuracy CO2 Monitor, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase II proposal seeks to develop a low cost, robust, highly precise and accurate CO2 monitoring system. This system will...

  16. Atmospheric density determination using high-accuracy satellite GPS data

    Science.gov (United States)

    Tingling, R.; Miao, J.; Liu, S.

    2017-12-01

    Atmospheric drag is the main error source in the orbit determination and prediction of low Earth orbit (LEO) satellites, however, empirical models which are used to account for atmosphere often exhibit density errors around 15 30%. Atmospheric density determination thus become an important topic for atmospheric researchers. Based on the relation between atmospheric drag force and the decay of orbit semi-major axis, we derived atmospheric density along the trajectory of CHAMP with its Rapid Science Orbit (RSO) data. Three primary parameters are calculated, including the ratio of cross sectional area to mass, drag coefficient, and the decay of semi-major axis caused by atmospheric drag. We also analyzed the source of error and made a comparison between GPS-derived and reference density. Result on 2 Dec 2008 shows that the mean error of GPS-derived density can decrease from 29.21% to 9.20% when time span adopted on the process of computation increase from 10min to 50min. Result for the whole December indicates that when the time span meet the condition that the amplitude of the decay of semi-major axis is much greater than its standard deviation, then density precision of 10% can be achieved.

  17. An ATLAS high mass dijet event

    CERN Multimedia

    ATLAS, Experiment

    2014-01-01

    A high mass dijet event: two high-pT jets with invariant mass 2.8 TeV. A track pT cut of 2.5 GeV has been applied for the display. 1st jet (ordered by pT): pT = 310 GeV, y = -2.0, φ = -0.2 2nd jet: pT = 280 GeV, y = 2.5, φ = 2.9 3rd jet: pT = 14 GeV, y = -0.9, φ = -1.0 Jet momenta are calibrated according to the "EM+JES" scheme. Event collected on 5 August 2010.

  18. Vector Boson Scattering at High Mass

    CERN Document Server

    The ATLAS collaboration

    2009-01-01

    In the absence of a light Higgs boson, the mechanism of electroweak symmetry breaking will be best studied in processes of vector boson scattering at high mass. Various models predict resonances in this channel. Here, we investigate $WW $scalar and vector resonances, $WZ$ vector resonances and a $ZZ$ scalar resonance over a range of diboson centre-of-mass energies. Particular attention is paid to the application of forward jet tagging and to the reconstruction of dijet pairs with low opening angle resulting from the decay of highly boosted vector bosons. The performances of different jet algorithms are compared. We find that resonances in vector boson scattering can be discovered with a few tens of inverse femtobarns of integrated luminosity.

  19. High-accuracy Subdaily ERPs from the IGS

    Science.gov (United States)

    Ray, J. R.; Griffiths, J.

    2012-04-01

    Since November 2000 the International GNSS Service (IGS) has published Ultra-rapid (IGU) products for near real-time (RT) and true real-time applications. They include satellite orbits and clocks, as well as Earth rotation parameters (ERPs) for a sliding 48-hr period. The first day of each update is based on the most recent GPS and GLONASS observational data from the IGS hourly tracking network. At the time of release, these observed products have an initial latency of 3 hr. The second day of each update consists of predictions. So the predictions between about 3 and 9 hr into the second half are relevant for true RT uses. Originally updated twice daily, the IGU products since April 2004 have been issued every 6 hr, at 3, 9, 15, and 21 UTC. Up to seven Analysis Centers (ACs) contribute to the IGU combinations. Two sets of ERPs are published with each IGU update, observed values at the middle epoch of the first half and predicted values at the middle epoch of the second half. The latency of the near RT ERPs is 15 hr while the predicted ERPs, based on projections of each AC's most recent determinations, are issued 9 hr ahead of their reference epoch. While IGU ERPs are issued every 6 hr, each set represents an integrated estimate over the surrounding 24 hr. So successive values are temporally correlated with about 75% of the data being common; this fact should be taken into account in user assimilations. To evaluate the accuracy of these near RT and predicted ERPs, they have been compared to the IGS Final ERPs, available about 11 to 17 d after data collection. The IGU products improved dramatically in the earlier years but since about 2008.0 the performance has been stable and excellent. During the last three years, RMS differences for the observed IGU ERPs have been about 0.036 mas and 0.0101 ms for each polar motion component and LOD respectively. (The internal precision of the reference IGS ERPs over the same period is about 0.016 mas for polar motion and 0

  20. Accuracy of Handheld Blood Glucose Meters at High Altitude

    NARCIS (Netherlands)

    de Mol, Pieter; Krabbe, Hans G.; de Vries, Suzanna T.; Fokkert, Marion J.; Dikkeschei, Bert D.; Rienks, Rienk; Bilo, Karin M.; Bilo, Henk J. G.

    2010-01-01

    Background: Due to increasing numbers of people with diabetes taking part in extreme sports (e. g., high-altitude trekking), reliable handheld blood glucose meters (BGMs) are necessary. Accurate blood glucose measurement under extreme conditions is paramount for safe recreation at altitude. Prior

  1. Innovative Fiber-Optic Gyroscopes (FOGs) for High Accuracy Space Applications, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This project aims to develop a compact, highly innovative Inertial Reference/Measurement Unit (IRU/IMU) that pushes the state-of-the-art in high accuracy performance...

  2. Accuracy of Body Mass Index-defined Obesity Status in US Firefighters

    Directory of Open Access Journals (Sweden)

    Nattinee Jitnarin

    2014-09-01

    Full Text Available Obesity is a significant problem affecting United States (US firefighters. While body mass index (BMI is widely used to diagnose obesity, its use for this occupational group has raised concerns about validity. We examined rates and types of misclassification of BMI-based obesity status compared to body fat percentage (BF% and waist circumference (WC. Male career firefighters (N = 994 from 20 US departments completed all three body composition assessments. Mean BMI, BF%, and WC were 29 kg/m2, 23%, and 97 cm, respectively. Approximately 33% and 15% of BF%- and WC-defined obese participants were misclassified as non-obese (false negatives using BMI, while 8% and 9% of non-obese participants defined by BF% and WC standards were identified as obese (false positives using BMI. When stratified by race/ethnicity, Pacific Islanders showed high rates of false positive misclassification. Precision in obesity classification would be improved by using WC along with BMI to determine firefighters' weight status.

  3. SPIRAL2/DESIR high resolution mass separator

    Energy Technology Data Exchange (ETDEWEB)

    Kurtukian-Nieto, T., E-mail: kurtukia@cenbg.in2p3.fr [Centre d’Études Nucléaires de Bordeaux Gradignan, Université Bordeaux 1-CNRS/IN2P3, BP 120, F-33175 Gradignan Cedex (France); Baartman, R. [TRIUMF, 4004 Wesbrook Mall, Vancouver B.C., V6T 2A3 (Canada); Blank, B.; Chiron, T. [Centre d’Études Nucléaires de Bordeaux Gradignan, Université Bordeaux 1-CNRS/IN2P3, BP 120, F-33175 Gradignan Cedex (France); Davids, C. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Delalee, F. [Centre d’Études Nucléaires de Bordeaux Gradignan, Université Bordeaux 1-CNRS/IN2P3, BP 120, F-33175 Gradignan Cedex (France); Duval, M. [GANIL, CEA/DSM-CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 5 (France); El Abbeir, S.; Fournier, A. [Centre d’Études Nucléaires de Bordeaux Gradignan, Université Bordeaux 1-CNRS/IN2P3, BP 120, F-33175 Gradignan Cedex (France); Lunney, D. [CSNSM-IN2P3-CNRS, Université de Paris Sud, F-91405 Orsay (France); Méot, F. [BNL, Upton, Long Island, New York (United States); Serani, L. [Centre d’Études Nucléaires de Bordeaux Gradignan, Université Bordeaux 1-CNRS/IN2P3, BP 120, F-33175 Gradignan Cedex (France); Stodel, M.-H.; Varenne, F. [GANIL, CEA/DSM-CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 5 (France); and others

    2013-12-15

    DESIR is the low-energy part of the SPIRAL2 ISOL facility under construction at GANIL. DESIR includes a high-resolution mass separator (HRS) with a designed resolving power m/Δm of 31,000 for a 1 π-mm-mrad beam emittance, obtained using a high-intensity beam cooling device. The proposed design consists of two 90-degree magnetic dipoles, complemented by electrostatic quadrupoles, sextupoles, and a multipole, arranged in a symmetric configuration to minimize aberrations. A detailed description of the design and results of extensive simulations are given.

  4. A High-Throughput, High-Accuracy System-Level Simulation Framework for System on Chips

    Directory of Open Access Journals (Sweden)

    Guanyi Sun

    2011-01-01

    Full Text Available Today's System-on-Chips (SoCs design is extremely challenging because it involves complicated design tradeoffs and heterogeneous design expertise. To explore the large solution space, system architects have to rely on system-level simulators to identify an optimized SoC architecture. In this paper, we propose a system-level simulation framework, System Performance Simulation Implementation Mechanism, or SPSIM. Based on SystemC TLM2.0, the framework consists of an executable SoC model, a simulation tool chain, and a modeling methodology. Compared with the large body of existing research in this area, this work is aimed at delivering a high simulation throughput and, at the same time, guaranteeing a high accuracy on real industrial applications. Integrating the leading TLM techniques, our simulator can attain a simulation speed that is not slower than that of the hardware execution by a factor of 35 on a set of real-world applications. SPSIM incorporates effective timing models, which can achieve a high accuracy after hardware-based calibration. Experimental results on a set of mobile applications proved that the difference between the simulated and measured results of timing performance is within 10%, which in the past can only be attained by cycle-accurate models.

  5. Impact of a highly detailed emission inventory on modeling accuracy

    Science.gov (United States)

    Taghavi, M.; Cautenet, S.; Arteta, J.

    2005-03-01

    During Expérience sur Site pour COntraindre les Modèles de Pollution atmosphérique et de Transport d'Emissions (ESCOMPTE) campaign (June 10 to July 14, 2001), two pollution events observed during an intensive measurement period (IOP2a and IOP2b) have been simulated. The comprehensive Regional Atmospheric Modeling Systems (RAMS) model, version 4.3, coupled online with a chemical module including 29 species is used to follow the chemistry of a polluted zone over Southern France. This online method takes advantage of a parallel code and use of the powerful computer SGI 3800. Runs are performed with two emission inventories: the Emission Pre Inventory (EPI) and the Main Emission Inventory (MEI). The latter is more recent and has a high resolution. The redistribution of simulated chemical species (ozone and nitrogen oxides) is compared with aircraft and surface station measurements for both runs at regional scale. We show that the MEI inventory is more efficient than the EPI in retrieving the redistribution of chemical species in space (three-dimensional) and time. In surface stations, MEI is superior especially for primary species, like nitrogen oxides. The ozone pollution peaks obtained from an inventory, such as EPI, have a large uncertainty. To understand the realistic geographical distribution of pollutants and to obtain a good order of magnitude in ozone concentration (in space and time), a high-resolution inventory like MEI is necessary. Coupling RAMS-Chemistry with MEI provides a very efficient tool able to simulate pollution plumes even in a region with complex circulations, such as the ESCOMPTE zone.

  6. Switched-capacitor techniques for high-accuracy filter and ADC design

    NARCIS (Netherlands)

    Quinn, P.J.; Roermund, van A.H.M.

    2007-01-01

    Switched capacitor (SC) techniques are well proven to be excellent candidates for implementing critical analogue functions with high accuracy, surpassing other analogue techniques when embedded in mixed-signal CMOS VLSI. Conventional SC circuits are primarily limited in accuracy by a) capacitor

  7. Evaluating the accuracy of uranium isotope amount ratio measurements performed by a quadrupole and a multi-collector magnetic sector inductively coupled plasma mass spectrometers for nuclear safeguards

    International Nuclear Information System (INIS)

    Pereira de Oliveira, O. Jr.; Sarkis, J.E.S.; Ponzevera, E.; Alonso, A.; De Bolle, W.; Quetel, C.

    2008-01-01

    The n(U 235 )/n(U 238 ) isotope amount ratio in a set of samples was measured using two modern analytical techniques: quadrupole inductively coupled plasma mass spectrometry (ICP-QMS) and multi-collector magnetic sector inductively coupled plasma mass spectrometry (MC-ICPMS). The measured ratios were compared to the certified ratios provided by the high accuracy gas source mass spectrometry (GSMS). The components of the uncertainty were identified and their contribution to the combined standard uncertainty was estimated using the recommendations of the ISO-GUM guide. The values of the measurement uncertainty and bias were determined and then compared to the International Target Values for Measurement Uncertainties in Safeguarding Nuclear Materials. It appears that only the measurements performed by MC-ICPMS can meet the stringent requirements of international nuclear safeguards. (authors)

  8. High accuracy laboratory spectroscopy to support active greenhouse gas sensing

    Science.gov (United States)

    Long, D. A.; Bielska, K.; Cygan, A.; Havey, D. K.; Okumura, M.; Miller, C. E.; Lisak, D.; Hodges, J. T.

    2011-12-01

    Recent carbon dioxide (CO2) remote sensing missions have set precision targets as demanding as 0.25% (1 ppm) in order to elucidate carbon sources and sinks [1]. These ambitious measurement targets will require the most precise body of spectroscopic reference data ever assembled. Active sensing missions will be especially susceptible to subtle line shape effects as the narrow bandwidth of these measurements will greatly limit the number of spectral transitions which are employed in retrievals. In order to assist these remote sensing missions we have employed frequency-stabilized cavity ring-down spectroscopy (FS-CRDS) [2], a high-resolution, ultrasensitive laboratory technique, to measure precise line shape parameters for transitions of O2, CO2, and other atmospherically-relevant species within the near-infrared. These measurements have led to new HITRAN-style line lists for both 16O2 [3] and rare isotopologue [4] transitions in the A-band. In addition, we have performed detailed line shape studies of CO2 transitions near 1.6 μm under a variety of broadening conditions [5]. We will address recent measurements in these bands as well as highlight recent instrumental improvements to the FS-CRDS spectrometer. These improvements include the use of the Pound-Drever-Hall locking scheme, a high bandwidth servo which enables measurements to be made at rates greater than 10 kHz [6]. In addition, an optical frequency comb will be utilized as a frequency reference, which should allow for transition frequencies to be measured with uncertainties below 10 kHz (3×10-7 cm-1). [1] C. E. Miller, D. Crisp, P. L. DeCola, S. C. Olsen, et al., J. Geophys. Res.-Atmos. 112, D10314 (2007). [2] J. T. Hodges, H. P. Layer, W. W. Miller, G. E. Scace, Rev. Sci. Instrum. 75, 849-863 (2004). [3] D. A. Long, D. K. Havey, M. Okumura, C. E. Miller, et al., J. Quant. Spectrosc. Radiat. Transfer 111, 2021-2036 (2010). [4] D. A. Long, D. K. Havey, S. S. Yu, M. Okumura, et al., J. Quant. Spectrosc

  9. The accuracy of QCD perturbation theory at high energies

    CERN Document Server

    Dalla Brida, Mattia; Korzec, Tomasz; Ramos, Alberto; Sint, Stefan; Sommer, Rainer

    2016-01-01

    We discuss the determination of the strong coupling $\\alpha_\\mathrm{\\overline{MS}}^{}(m_\\mathrm{Z})$ or equivalently the QCD $\\Lambda$-parameter. Its determination requires the use of perturbation theory in $\\alpha_s(\\mu)$ in some scheme, $s$, and at some energy scale $\\mu$. The higher the scale $\\mu$ the more accurate perturbation theory becomes, owing to asymptotic freedom. As one step in our computation of the $\\Lambda$-parameter in three-flavor QCD, we perform lattice computations in a scheme which allows us to non-perturbatively reach very high energies, corresponding to $\\alpha_s = 0.1$ and below. We find that perturbation theory is very accurate there, yielding a three percent error in the $\\Lambda$-parameter, while data around $\\alpha_s \\approx 0.2$ is clearly insufficient to quote such a precision. It is important to realize that these findings are expected to be generic, as our scheme has advantageous properties regarding the applicability of perturbation theory.

  10. A New Three-Dimensional High-Accuracy Automatic Alignment System For Single-Mode Fibers

    Science.gov (United States)

    Yun-jiang, Rao; Shang-lian, Huang; Ping, Li; Yu-mei, Wen; Jun, Tang

    1990-02-01

    In order to achieve the low-loss splices of single-mode fibers, a new three-dimension high-accuracy automatic alignment system for single -mode fibers has been developed, which includes a new-type three-dimension high-resolution microdisplacement servo stage driven by piezoelectric elements, a new high-accuracy measurement system for the misalignment error of the fiber core-axis, and a special single chip microcomputer processing system. The experimental results show that alignment accuracy of ±0.1 pin with a movable stroke of -±20μm has been obtained. This new system has more advantages than that reported.

  11. Accuracy Assessment for the Three-Dimensional Coordinates by High-Speed Videogrammetric Measurement

    Directory of Open Access Journals (Sweden)

    Xianglei Liu

    2018-01-01

    Full Text Available High-speed CMOS camera is a new kind of transducer to make the videogrammetric measurement for monitoring the displacement of high-speed shaking table structure. The purpose of this paper is to validate the three-dimensional coordinate accuracy of the shaking table structure acquired from the presented high-speed videogrammetric measuring system. In the paper, all of the key intermediate links are discussed, including the high-speed CMOS videogrammetric measurement system, the layout of the control network, the elliptical target detection, and the accuracy validation of final 3D spatial results. Through the accuracy analysis, the submillimeter accuracy can be made for the final the three-dimensional spatial coordinates which certify that the proposed high-speed videogrammetric technique is a better alternative technique which can replace the traditional transducer technique for monitoring the dynamic response for the shaking table structure.

  12. HOT HIGH-MASS ACCRETION DISK CANDIDATES

    International Nuclear Information System (INIS)

    Beuther, H.; Walsh, A. J.; Longmore, S. N.

    2009-01-01

    To better understand the physical properties of accretion disks in high-mass star formation, we present a study of a dozen high-mass accretion disk candidates observed at high spatial resolution with the Australia Telescope Compact Array (ATCA) in the high-excitation (4,4) and (5,5) lines of NH 3 . All of our originally selected sources were detected in both NH 3 transitions, directly associated with CH 3 OH Class II maser emission and implying that high-excitation NH 3 lines are good tracers of the dense gas components in hot-core-type targets. Only the one source that did not satisfy the initial selection criteria remained undetected. From the 11 mapped sources, six show clear signatures of rotation and/or infall motions. These signatures vary from velocity gradients perpendicular to the outflows, to infall signatures in absorption against ultracompact H II regions, to more spherical infall signatures in emission. Although our spatial resolution is ∼1000 AU, we do not find clear Keplerian signatures in any of the sources. Furthermore, we also do not find flattened structures. In contrast to this, in several of the sources with rotational signatures, the spatial structure is approximately spherical with sizes exceeding 10 4 AU, showing considerable clumpy sub-structure at even smaller scales. This implies that on average typical Keplerian accretion disks-if they exist as expected-should be confined to regions usually smaller than 1000 AU. It is likely that these disks are fed by the larger-scale rotating envelope structure we observe here. Furthermore, we do detect 1.25 cm continuum emission in most fields of view. While in some cases weak cm continuum emission is associated with our targets, more typically larger-scale H II regions are seen offset more than 10'' from our sources. While these H II regions are unlikely to be directly related to the target regions, this spatial association nevertheless additionally stresses that high-mass star formation rarely

  13. High-accuracy determination for optical indicatrix rotation in ferroelectric DTGS

    OpenAIRE

    O.S.Kushnir; O.A.Bevz; O.G.Vlokh

    2000-01-01

    Optical indicatrix rotation in deuterated ferroelectric triglycine sulphate is studied with the high-accuracy null-polarimetric technique. The behaviour of the effect in ferroelectric phase is referred to quadratic spontaneous electrooptics.

  14. Mass Evolution of Mediterranean, Black, Red, and Caspian Seas from GRACE and Altimetry: Accuracy Assessment and Solution Calibration

    Science.gov (United States)

    Loomis, B. D.; Luthcke, S. B.

    2016-01-01

    We present new measurements of mass evolution for the Mediterranean, Black, Red, and Caspian Seas as determined by the NASA Goddard Space Flight Center (GSFC) GRACE time-variable global gravity mascon solutions. These new solutions are compared to sea surface altimetry measurements of sea level anomalies with steric corrections applied. To assess their accuracy, the GRACE and altimetry-derived solutions are applied to the set of forward models used by GSFC for processing the GRACE Level-1B datasets, with the resulting inter-satellite range acceleration residuals providing a useful metric for analyzing solution quality.

  15. Accuracy of Body Mass Index-defined Obesity Status in US Firefighters

    OpenAIRE

    Jitnarin, Nattinee; Poston, Walker S.C.; Haddock, Christopher K.; Jahnke, Sara A.; Day, Rena S.

    2014-01-01

    Obesity is a significant problem affecting United States (US) firefighters. While body mass index (BMI) is widely used to diagnose obesity, its use for this occupational group has raised concerns about validity. We examined rates and types of misclassification of BMI-based obesity status compared to body fat percentage (BF%) and waist circumference (WC). Male career firefighters (N = 994) from 20 US departments completed all three body composition assessments. Mean BMI, BF%, and WC were 29 kg...

  16. Heat-Treatment-Responsive Proteins in Different Developmental Stages of Tomato Pollen Detected by Targeted Mass Accuracy Precursor Alignment (tMAPA).

    Science.gov (United States)

    Chaturvedi, Palak; Doerfler, Hannes; Jegadeesan, Sridharan; Ghatak, Arindam; Pressman, Etan; Castillejo, Maria Angeles; Wienkoop, Stefanie; Egelhofer, Volker; Firon, Nurit; Weckwerth, Wolfram

    2015-11-06

    Recently, we have developed a quantitative shotgun proteomics strategy called mass accuracy precursor alignment (MAPA). The MAPA algorithm uses high mass accuracy to bin mass-to-charge (m/z) ratios of precursor ions from LC-MS analyses, determines their intensities, and extracts a quantitative sample versus m/z ratio data alignment matrix from a multitude of samples. Here, we introduce a novel feature of this algorithm that allows the extraction and alignment of proteotypic peptide precursor ions or any other target peptide from complex shotgun proteomics data for accurate quantification of unique proteins. This strategy circumvents the problem of confusing the quantification of proteins due to indistinguishable protein isoforms by a typical shotgun proteomics approach. We applied this strategy to a comparison of control and heat-treated tomato pollen grains at two developmental stages, post-meiotic and mature. Pollen is a temperature-sensitive tissue involved in the reproductive cycle of plants and plays a major role in fruit setting and yield. By LC-MS-based shotgun proteomics, we identified more than 2000 proteins in total for all different tissues. By applying the targeted MAPA data-processing strategy, 51 unique proteins were identified as heat-treatment-responsive protein candidates. The potential function of the identified candidates in a specific developmental stage is discussed.

  17. High body mass index and cancer risk

    DEFF Research Database (Denmark)

    Benn, Marianne; Tybjærg-Hansen, Anne; Smith, George Davey

    2016-01-01

    of follow-up (range 0-37), 8002 developed non-skin cancer, 3347 non-melanoma skin cancer, 1396 lung cancer, 637 other smoking related cancers, 1203 colon cancer, 159 kidney cancer, 1402 breast cancer, 1062 prostate cancer, and 2804 other cancers. Participants were genotyped for five genetic variants...... with a BMI ≥ 30 versus 18.5-24.9 kg/m(2). Corresponding risk of breast cancer was 20 % (0-44 %) higher in postmenopausal women. BMI was not associated with risk of colon, kidney, other smoking related cancers, prostate cancer, or other cancers. In genetic analyses, carrying 7-10 versus 0-4 BMI increasing......High body mass index (BMI) has been associated with increased risk of some cancer. Whether these reflect causal associations is unknown. We examined this issue. Using a Mendelian randomisation approach, we studied 108,812 individuals from the general population. During a median of 4.7 years...

  18. Use of prediction equations to determine the accuracy of whole-body fat and fat-free mass and appendicular skeletal muscle mass measurements from a single abdominal image using computed tomography in advanced cancer patients.

    Science.gov (United States)

    Kilgour, Robert D; Cardiff, Katrina; Rosenthall, Leonard; Lucar, Enriqueta; Trutschnigg, Barbara; Vigano, Antonio

    2016-01-01

    Measurements of body composition using dual-energy X-ray absorptiometry (DXA) and single abdominal images from computed tomography (CT) in advanced cancer patients (ACP) have important diagnostic and prognostic value. The question arises as to whether CT scans can serve as surrogates for DXA in terms of whole-body fat-free mass (FFM), whole-body fat mass (FM), and appendicular skeletal muscle (ASM) mass. Predictive equations to estimate body composition for ACP from CT images have been proposed (Mourtzakis et al. 2008; Appl. Physiol. Nutr. Metabol. 33(5): 997-1006); however, these equations have yet to be validated in an independent cohort of ACP. Thus, this study evaluated the accuracy of these equations in estimating FFM, FM, and ASM mass using CT images at the level of the third lumbar vertebrae and compared these values with DXA measurements. FFM, FM, and ASM mass were estimated from the prediction equations proposed by Mourtzakis and colleagues (2008) using single abdominal CT images from 43 ACP and were compared with whole-body DXA scans using Spearman correlations and Bland-Altman analyses. Despite a moderate to high correlation between the actual (DXA) and predicted (CT) values for FM (rho = 0.93; p ≤ 0.001), FFM (rho = 0.78; p ≤ 0.001), and ASM mass (rho = 0.70; p ≤ 0.001), Bland-Altman analyses revealed large range-of-agreement differences between the 2 methods (29.39 kg for FFM, 15.47 kg for FM, and 3.99 kg for ASM mass). Based on the magnitude of these differences, we concluded that prediction equations using single abdominal CT images have poor accuracy, cannot be considered as surrogates for DXA, and may have limited clinical utility.

  19. Evaluate the accuracy of the numerical solution of hydrogeological problems of mass transfer

    Directory of Open Access Journals (Sweden)

    Yevhrashkina G.P.

    2014-12-01

    Full Text Available In the hydrogeological task on quantifying pollution of aquifers the error are starting add up with moment organization of regime observation network as a source of information on the pollution of groundwater in order to evaluate migration options for future prognosis calculations. Optimum element regime observation network should consist of three drill holes on the groundwater flow at equal distances from one another and transversely to the flow of the three drill holes, and at equal distances. If the target of observation drill holes coincides with the stream line on which will then be decided by direct migration task, the error will be minimal. The theoretical basis and results of numerical experiments to assess the accuracy of direct predictive tasks planned migration of groundwater in the area of full water saturation. For the vadose zone, we consider problems of vertical salt transport moisture. All studies were performed by comparing the results of fundamental and approximate solutions in a wide range of characteristics of the processes, which are discussed in relation to ecological and hydrogeological conditions of mining regions on the example of the Western Donbass.

  20. The effect of pattern overlap on the accuracy of high resolution electron backscatter diffraction measurements

    Energy Technology Data Exchange (ETDEWEB)

    Tong, Vivian, E-mail: v.tong13@imperial.ac.uk [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2AZ (United Kingdom); Jiang, Jun [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2AZ (United Kingdom); Wilkinson, Angus J. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Britton, T. Ben [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2AZ (United Kingdom)

    2015-08-15

    High resolution, cross-correlation-based, electron backscatter diffraction (EBSD) measures the variation of elastic strains and lattice rotations from a reference state. Regions near grain boundaries are often of interest but overlap of patterns from the two grains could reduce accuracy of the cross-correlation analysis. To explore this concern, patterns from the interior of two grains have been mixed to simulate the interaction volume crossing a grain boundary so that the effect on the accuracy of the cross correlation results can be tested. It was found that the accuracy of HR-EBSD strain measurements performed in a FEG-SEM on zirconium remains good until the incident beam is less than 18 nm from a grain boundary. A simulated microstructure was used to measure how often pattern overlap occurs at any given EBSD step size, and a simple relation was found linking the probability of overlap with step size. - Highlights: • Pattern overlap occurs at grain boundaries and reduces HR-EBSD accuracy. • A test is devised to measure the accuracy of HR-EBSD in the presence of overlap. • High pass filters can sometimes, but not generally, improve HR-EBSD measurements. • Accuracy of HR-EBSD remains high until the reference pattern intensity is <72%. • 9% of points near a grain boundary will have significant error for 200nm step size in Zircaloy-4.

  1. High-accuracy drilling with an image guided light weight robot: autonomous versus intuitive feed control.

    Science.gov (United States)

    Tauscher, Sebastian; Fuchs, Alexander; Baier, Fabian; Kahrs, Lüder A; Ortmaier, Tobias

    2017-10-01

    Assistance of robotic systems in the operating room promises higher accuracy and, hence, demanding surgical interventions become realisable (e.g. the direct cochlear access). Additionally, an intuitive user interface is crucial for the use of robots in surgery. Torque sensors in the joints can be employed for intuitive interaction concepts. Regarding the accuracy, they lead to a lower structural stiffness and, thus, to an additional error source. The aim of this contribution is to examine, if an accuracy needed for demanding interventions can be achieved by such a system or not. Feasible accuracy results of the robot-assisted process depend on each work-flow step. This work focuses on the determination of the tool coordinate frame. A method for drill axis definition is implemented and analysed. Furthermore, a concept of admittance feed control is developed. This allows the user to control feeding along the planned path by applying a force to the robots structure. The accuracy is researched by drilling experiments with a PMMA phantom and artificial bone blocks. The described drill axis estimation process results in a high angular repeatability ([Formula: see text]). In the first set of drilling results, an accuracy of [Formula: see text] at entrance and [Formula: see text] at target point excluding imaging was achieved. With admittance feed control an accuracy of [Formula: see text] at target point was realised. In a third set twelve holes were drilled in artificial temporal bone phantoms including imaging. In this set-up an error of [Formula: see text] and [Formula: see text] was achieved. The results of conducted experiments show that accuracy requirements for demanding procedures such as the direct cochlear access can be fulfilled with compliant systems. Furthermore, it was shown that with the presented admittance feed control an accuracy of less then [Formula: see text] is achievable.

  2. Adaptive sensor-based ultra-high accuracy solar concentrator tracker

    Science.gov (United States)

    Brinkley, Jordyn; Hassanzadeh, Ali

    2017-09-01

    Conventional solar trackers use information of the sun's position, either by direct sensing or by GPS. Our method uses the shading of the receiver. This, coupled with nonimaging optics design allows us to achieve ultra-high concentration. Incorporating a sensor based shadow tracking method with a two stage concentration solar hybrid parabolic trough allows the system to maintain high concentration with acute accuracy.

  3. Three-dimensional echocardiography: assessment of inter- and intra-operator variability and accuracy in the measurement of left ventricular cavity volume and myocardial mass

    International Nuclear Information System (INIS)

    Nadkarni, S.K.; Drangova, M.; Boughner, D.R.; Fenster, A.; Department of Medical Biophysics, Medical Sciences Building, University of Western Ontario, London, Ontario N6A 5C1

    2000-01-01

    Accurate left ventricular (LV) volume and mass estimation is a strong predictor of cardiovascular morbidity and mortality. We propose that our technique of 3D echocardiography provides an accurate quantification of LV volume and mass by the reconstruction of 2D images into 3D volumes, thus avoiding the need for geometric assumptions. We compared the accuracy and variability in LV volume and mass measurement using 3D echocardiography with 2D echocardiography, using in vitro studies. Six operators measured the LV volume and mass of seven porcine hearts, using both 3D and 2D techniques. Regression analysis was used to test the accuracy of results and an ANOVA test was used to compute variability in measurement. LV volume measurement accuracy was 9.8% (3D) and 18.4% (2D); LV mass measurement accuracy was 5% (3D) and 9.2% (2D). Variability in LV volume quantification with 3D echocardiography was %SEM inter = 13.5%, %SEM intra = 11.4%, and for 2D echocardiography was %SEM inter = 21.5%, %SEM intra = 19.1%. We derived an equation to predict uncertainty in measurement of LV volume and mass using 3D echocardiography, the results of which agreed with our experimental results to within 13%. 3D echocardiography provided twice the accuracy for LV volume and mass measurement and half the variability for LV volume measurement as compared with 2D echocardiography. (author)

  4. Diagnostic accuracy of dynamic contrast-enhanced MR imaging of renal masses with rapid-acquisition spin-echo technique

    International Nuclear Information System (INIS)

    Eilenberg, S.S.; Lee, J.K.T.; Brown, J.J.; Heiken, J.P.; Mirowitz, S.A.

    1990-01-01

    This paper compares the diagnostic accuracy of Gd-DTPA-enhanced rapid-acquisition spin-echo (RASE) imaging with standard spin-echo techniques for detecting renal cysts and solid renal neoplasms. RASE imaging combines a short TR (275 msec)/short TE (10 msec), single excitation pulse sequence with half-Fourier data sampling. Eighteen patients with CT evidence of renal masses were first evaluated with standard T1-and T2-weighted SE sequences. Pre- and serial postcontrast (Cd-DTPA, 0.1 mmol./kg) RASE sequences were then performed during suspended respiration. A final set of postcontrast images was obtained with the standard T1-weighted SE sequence. Each set of MR images was first reviewed separately (ie, T1, T2, pre- and post-contrast RASE, etc)

  5. High accuracy determination of trace elements in NIST standard reference materials by isotope dilution ICP-MS

    International Nuclear Information System (INIS)

    Paulsen, P.J.; Beary, E.S.

    1996-01-01

    At NIST (National Institute of Standards and Technology), ICP-MS ID (inductively coupled mass spectrometry isotope dilution) has been used to certify a wide range of elements in a variety of materials with high accuracy. Both the chemical preparation and instrumental procedures are simpler than with other ID mass spectrometric techniques. The ICP-MS has picogram/ml detection limits for most elements using fixed operating parameters. Chemical separations are required only to remove an interference (from molecular ions as well as isobaric atoms), or to pre-concentrate the analyte. For example, chemical separations were required for the analysis of SRM 2711, Montana II Soil, but not for boron in peach leaves, SRM 1547.(3 refs., 3 tabs., 2 figs

  6. Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate

    DEFF Research Database (Denmark)

    Andersen, Trine Borup; Jødal, Lars; Bøgsted, Martin

    ) aged 2-14 years (mean 8.8 years). GFR was 14-147 mL/min/1.73m2 (mean 97 mL/min/1.73m2). BCM was estimated using bioimpedance spectroscopy (Xitron Hydra 4200). Log-transformed data on BCM/CysC, serum creatinine (SCr), body-surface-area (BSA), height x BSA/SCr, serum CysC, weight, sex, age, height, serum....... The present equation also had the highest R2 and the narrowest 95% limits of agreement. CONCLUSION: The new equation predicts GFR with higher accuracy than other equations. Endogenous methods are, however, still not accurate enough to replace exogenous markers when GFR must be determined with high accuracy...

  7. GFR prediction from cystatin C and creatinine in children: body cell mass increases accuracy of the estimate

    DEFF Research Database (Denmark)

    Andersen, Trine Borup; Jødal, Lars; Bøgsted, Martin

    ) aged 2-14 years (mean 8.8 years). GFR was 14-147 mL/min/1.73m2 (mean 97 mL/min/1.73m2). BCM was estimated using bioimpedance spectroscopy (Xitron Hydra 4200). Log-transformed data on BCM/CysC, serum creatinine (SCr), body-surface-area (BSA), height x BSA/SCr, serum CysC, weight, sex, age, height, serum....... The present equation also had the highest R2 and the narrowest 95% limits of agreement. CONCLUSION: The new equation predicts GFR with higher accuracy than other equations. Endogenous methods are, however, still not accurate enough to replace exogenous markers when GFR must be determined with high accuracy...

  8. Spectroscopic characterization of galaxy clusters in RCS-1: spectroscopic confirmation, redshift accuracy, and dynamical mass-richness relation

    Science.gov (United States)

    Gilbank, David G.; Barrientos, L. Felipe; Ellingson, Erica; Blindert, Kris; Yee, H. K. C.; Anguita, T.; Gladders, M. D.; Hall, P. B.; Hertling, G.; Infante, L.; Yan, R.; Carrasco, M.; Garcia-Vergara, Cristina; Dawson, K. S.; Lidman, C.; Morokuma, T.

    2018-05-01

    We present follow-up spectroscopic observations of galaxy clusters from the first Red-sequence Cluster Survey (RCS-1). This work focuses on two samples, a lower redshift sample of ˜30 clusters ranging in redshift from z ˜ 0.2-0.6 observed with multiobject spectroscopy (MOS) on 4-6.5-m class telescopes and a z ˜ 1 sample of ˜10 clusters 8-m class telescope observations. We examine the detection efficiency and redshift accuracy of the now widely used red-sequence technique for selecting clusters via overdensities of red-sequence galaxies. Using both these data and extended samples including previously published RCS-1 spectroscopy and spectroscopic redshifts from SDSS, we find that the red-sequence redshift using simple two-filter cluster photometric redshifts is accurate to σz ≈ 0.035(1 + z) in RCS-1. This accuracy can potentially be improved with better survey photometric calibration. For the lower redshift sample, ˜5 per cent of clusters show some (minor) contamination from secondary systems with the same red-sequence intruding into the measurement aperture of the original cluster. At z ˜ 1, the rate rises to ˜20 per cent. Approximately ten per cent of projections are expected to be serious, where the two components contribute significant numbers of their red-sequence galaxies to another cluster. Finally, we present a preliminary study of the mass-richness calibration using velocity dispersions to probe the dynamical masses of the clusters. We find a relation broadly consistent with that seen in the local universe from the WINGS sample at z ˜ 0.05.

  9. Characterization of ANFO explosive by high accuracy ESI(±)-FTMS with forensic identification on real samples by EASI(-)-MS.

    Science.gov (United States)

    Hernandes, Vinicius Veri; Franco, Marcos Fernado; Santos, Jandyson Machado; Melendez-Perez, Jose J; de Morais, Damila Rodrigues; Rocha, Werickson Fortunato de Carvalho; Borges, Rodrigo; de Souza, Wanderley; Zacca, Jorge Jardim; Logrado, Lucio Paulo Lima; Eberlin, Marcos Nogueira; Correa, Deleon Nascimento

    2015-04-01

    Ammonium nitrate fuel oil (ANFO) is an explosive used in many civil applications. In Brazil, ANFO has unfortunately also been used in criminal attacks, mainly in automated teller machine (ATM) explosions. In this paper, we describe a detailed characterization of the ANFO composition and its two main constituents (diesel and a nitrate explosive) using high resolution and accuracy mass spectrometry performed on an FT-ICR-mass spectrometer with electrospray ionization (ESI(±)-FTMS) in both the positive and negative ion modes. Via ESI(-)-MS, an ion marker for ANFO was characterized. Using a direct and simple ambient desorption/ionization technique, i.e., easy ambient sonic-spray ionization mass spectrometry (EASI-MS), in a simpler, lower accuracy but robust single quadrupole mass spectrometer, the ANFO ion marker was directly detected from the surface of banknotes collected from ATM explosion theft. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Radiative and semi-leptonic B-meson decay spectra: Sudakov resummation beyond logarithmic accuracy and the pole mass

    Science.gov (United States)

    Gardi, Einan

    2004-04-01

    The inclusive spectra of radiative and semi-leptonic B-meson decays near the endpoint is computed taking into account renormalons in the Sudakov exponent (Dressed Gluon Exponentiation). In this framework we demonstrate the factorization of decay spectra into hard, jet and soft functions and discuss the universality of the latter two. Going beyond perturbation theory the soft function, which we identify as the longitudinal momentum distribution in an on-shell b quark, is replaced by the b-quark distribution in the B meson. The two differ by power corrections. We show how the resummation of running-coupling effects can be used to perform consistent separation to power accuracy between perturbative and non-perturbative contributions. In particular, we prove that the leading infrared renormalon ambiguity in the Sudakov exponent cancels against the one associated with the definition of the pole mass. This cancellation allows us to identify the non-perturbative parameter that controls the shift of the perturbative spectrum in the heavy-quark limit as the mass difference between the meson and the quark.

  11. Accuracy of hiatal hernia detection with esophageal high-resolution manometry

    NARCIS (Netherlands)

    Weijenborg, P. W.; van Hoeij, F. B.; Smout, A. J. P. M.; Bredenoord, A. J.

    2015-01-01

    The diagnosis of a sliding hiatal hernia is classically made with endoscopy or barium esophagogram. Spatial separation of the lower esophageal sphincter (LES) and diaphragm, the hallmark of hiatal hernia, can also be observed on high-resolution manometry (HRM), but the diagnostic accuracy of this

  12. High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast

    DEFF Research Database (Denmark)

    Gnad, Florian; de Godoy, Lyris M F; Cox, Jürgen

    2009-01-01

    Protein phosphorylation is a fundamental regulatory mechanism that affects many cell signaling processes. Using high-accuracy MS and stable isotope labeling in cell culture-labeling, we provide a global view of the Saccharomyces cerevisiae phosphoproteome, containing 3620 phosphorylation sites ma...

  13. High accuracy positioning using carrier-phases with the opensource GPSTK software

    OpenAIRE

    Salazar Hernández, Dagoberto José; Hernández Pajares, Manuel; Juan Zornoza, José Miguel; Sanz Subirana, Jaume

    2008-01-01

    The objective of this work is to show how using a proper GNSS data management strategy, combined with the flexibility provided by the open source "GPS Toolkit" (GPSTk), it is possible to easily develop both simple code-based processing strategies as well as basic high accuracy carrier-phase positioning techniques like Precise Point Positioning (PPP

  14. Very high-accuracy calibration of radiation pattern and gain of a near-field probe

    DEFF Research Database (Denmark)

    Pivnenko, Sergey; Nielsen, Jeppe Majlund; Breinbjerg, Olav

    2014-01-01

    In this paper, very high-accuracy calibration of the radiation pattern and gain of a near-field probe is described. An open-ended waveguide near-field probe has been used in a recent measurement of the C-band Synthetic Aperture Radar (SAR) Antenna Subsystem for the Sentinel 1 mission of the Europ...

  15. From journal to headline: the accuracy of climate science news in Danish high quality newspapers

    DEFF Research Database (Denmark)

    Vestergård, Gunver Lystbæk

    2011-01-01

    analysis to examine the accuracy of Danish high quality newspapers in quoting scientific publications from 1997 to 2009. Out of 88 articles, 46 contained inaccuracies though the majority was found to be insignificant and random. The study concludes that Danish broadsheet newspapers are ‘moderately...

  16. Evaluation and optimization of high-performance liquid chromatography coupled with high-resolution mass spectrometry for phospholipid quantitation.

    Science.gov (United States)

    Fu, Mingkun; Xu, Wei; Lu, Qing; Pan, Guoyu; Varga, Csanad

    2014-04-15

    High-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC/HRMS) provides an attractive alternative to the traditional triple quadrupole mass spectrometry selected reaction monitoring (SRM) methodology in the field of quantitation. An LTQ Orbitrap Velos mass spectrometer coupled with a Shimadzu UHPLC system was used. A mass extraction window (MEW) was defined to mathematically correlate with mass resolving power (MRP). Five MRP measurement conditions at 7500, 15,000, 30,000, 60,000, and 100,000, and five MEW widths at 10%, 20%, 50%, and 100% of ±1000000/MRP, and were utilized as the experimental conditions. Comparison of profile and centroid algorithms was evaluated as well. Selection of pH 8.5 buffer, C4 column, 20% IPA, and 10 ppm H3 PO4 , minimized hydrophobic and silanol interactions to enhance separation. Narrowing the MEW minimized background noise, while over-narrowing the MEW gave signal loss due to mass accuracy deviation. The mass accuracy deviation was larger for lower MRP measurements especially with centriod data, and hence a profile algorithm was recommended. The post-ionization signal suppression was observed with low MRP and was further confirmed with the analysis of multi-level linearity. It was found that the HPLC/HRMS method with conditions of 20% ±1000000/MRP as MEW, 30,000 or 60,000 MRP, and profile algorithm, provide optimum results for quantitation of seven model phospholipids. Copyright © 2014 John Wiley & Sons, Ltd.

  17. Technics study on high accuracy crush dressing and sharpening of diamond grinding wheel

    Science.gov (United States)

    Jia, Yunhai; Lu, Xuejun; Li, Jiangang; Zhu, Lixin; Song, Yingjie

    2011-05-01

    Mechanical grinding of artificial diamond grinding wheel was traditional wheel dressing process. The rotate speed and infeed depth of tool wheel were main technics parameters. The suitable technics parameters of metals-bonded diamond grinding wheel and resin-bonded diamond grinding wheel high accuracy crush dressing were obtained by a mount of experiment in super-hard material wheel dressing grind machine and by analysis of grinding force. In the same time, the effect of machine sharpening and sprinkle granule sharpening was contrasted. These analyses and lots of experiments had extent instruction significance to artificial diamond grinding wheel accuracy crush dressing.

  18. High accuracy interface characterization of three phase material systems in three dimensions

    DEFF Research Database (Denmark)

    Jørgensen, Peter Stanley; Hansen, Karin Vels; Larsen, Rasmus

    2010-01-01

    Quantification of interface properties such as two phase boundary area and triple phase boundary length is important in the characterization ofmanymaterial microstructures, in particular for solid oxide fuel cell electrodes. Three-dimensional images of these microstructures can be obtained...... by tomography schemes such as focused ion beam serial sectioning or micro-computed tomography. We present a high accuracy method of calculating two phase surface areas and triple phase length of triple phase systems from subvoxel accuracy segmentations of constituent phases. The method performs a three phase...... polygonization of the interface boundaries which results in a non-manifold mesh of connected faces. We show how the triple phase boundaries can be extracted as connected curve loops without branches. The accuracy of the method is analyzed by calculations on geometrical primitives...

  19. Automated novel high-accuracy miniaturized positioning system for use in analytical instrumentation

    Science.gov (United States)

    Siomos, Konstadinos; Kaliakatsos, John; Apostolakis, Manolis; Lianakis, John; Duenow, Peter

    1996-01-01

    The development of three-dimensional automotive devices (micro-robots) for applications in analytical instrumentation, clinical chemical diagnostics and advanced laser optics, depends strongly on the ability of such a device: firstly to be positioned with high accuracy, reliability, and automatically, by means of user friendly interface techniques; secondly to be compact; and thirdly to operate under vacuum conditions, free of most of the problems connected with conventional micropositioners using stepping-motor gear techniques. The objective of this paper is to develop and construct a mechanically compact computer-based micropositioning system for coordinated motion in the X-Y-Z directions with: (1) a positioning accuracy of less than 1 micrometer, (the accuracy of the end-position of the system is controlled by a hard/software assembly using a self-constructed optical encoder); (2) a heat-free propulsion mechanism for vacuum operation; and (3) synchronized X-Y motion.

  20. High-Latitude Neutral Mass Density Maxima

    Science.gov (United States)

    Huang, C. Y.; Huang, Y.; Su, Y.-J.; Huang, T.; Sutton, E. K.

    2017-10-01

    Recent studies have reported that thermospheric effects due to solar wind driving can be observed poleward of auroral latitudes. In these papers, the measured neutral mass density perturbations appear as narrow, localized maxima in the cusp and polar cap. They conclude that Joule heating below the spacecraft is the cause of the mass density increases, which are sometimes associated with local field-aligned current structures, but not always. In this paper we investigate neutral mass densities measured by accelerometers on the CHAllenging Minisatellite Payload (CHAMP) and Gravity Recovery and Climate Experiment (GRACE) spacecraft from launch until years 2010 (CHAMP) and 2012 (GRACE), approximately 10 years of observations from each satellite. We extract local maxima in neutral mass densities over the background using a smoothing window with size of one quarter of the orbit. The maxima have been analyzed for each year and also for the duration of each set of satellite observations. We show where they occur, under what solar wind conditions, and their relation to magnetic activity. The region with the highest frequency of occurrence coincides approximately with the cusp and mantle, with little direct evidence of an auroral zone source. Our conclusions agree with the "hot polar cap" observations that have been reported and studied in the past.

  1. Performance results of a mobile high-resolution MR-TOF mass spectrometer for in-situ analytical mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lippert, Wayne; Lang, Johannes [Justus-Liebig-Universitaet Giessen (Germany); Ayet San Andres, Samuel [GSI, Darmstadt (Germany); Dickel, Timo; Geissel, Hans; Plass, Wolfgang; Scheidenberger, Christoph [Justus-Liebig-Universitaet Giessen (Germany); GSI, Darmstadt (Germany); Yavor, Mikhail [RAS St. Petersburg (Russian Federation)

    2014-07-01

    A mobile multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) has been developed which provides a mass resolving power exceeding 250,000 and sub-ppm mass accuracy in a transportable format. Thus it allows resolving isobars and enables accurate determination of the composition and structure of biomolecules. Furthermore the device offers high mass resolving MS/MS capability via selective ion re-trapping and collisional-induced dissociation (CID). An atmospheric pressure interface (API) provides for routine measurements with various atmospheric ion sources. All supply electronics, DAQ and control system are mounted with the spectrometer into a single frame with a total volume of only 0.8 m{sup 3}. With the current system many applications like waste water monitoring at hot spots, mass-based classification of biomolecules and breath analysis are possible. In addition the mass spectrometer is readily scalable and can be adopted and simplified for even more specific use like in space science for instance. A characterization and first performance results are shown, and the implementation of MS/MS in combination with CID is discussed.

  2. Accuracy of Coverage Survey Recall following an Integrated Mass Drug Administration for Lymphatic Filariasis, Schistosomiasis, and Soil-Transmitted Helminthiasis

    Science.gov (United States)

    Budge, Philip J.; Sognikin, Edmond; Akosa, Amanda; Mathieu, Els M.; Deming, Michael

    2016-01-01

    Background Achieving target coverage levels for mass drug administration (MDA) is essential to elimination and control efforts for several neglected tropical diseases (NTD). To ensure program goals are met, coverage reported by drug distributors may be validated through household coverage surveys that rely on respondent recall. This is the first study to assess accuracy in such surveys. Methodology/Principal Findings Recall accuracy was tested in a series of coverage surveys conducted at 1, 6, and 12 months after an integrated MDA in Togo during which three drugs (albendazole, ivermectin, and praziquantel) were distributed. Drug distribution was observed during the MDA to ensure accurate recording of persons treated during the MDA. Information was obtained for 506, 1131, and 947 persons surveyed at 1, 6, and 12 months, respectively. Coverage (defined as the percentage of persons taking at least one of the MDA medications) within these groups was respectively 88.3%, 87.4%, and 80.0%, according to the treatment registers; it was 87.9%, 91.4% and 89.4%, according to survey responses. Concordance between respondents and registers on swallowing at least one pill was >95% at 1 month and >86% at 12 months; the lower concordance at 12 months was more likely due to difficulty matching survey respondents with the year-old treatment register rather than inaccurate responses. Respondents generally distinguished between pills similar in appearance; concordance for recall of which pills were taken was over 80% in each survey. Significance In this population, coverage surveys provided remarkably consistent coverage estimates for up to one year following an integrated MDA. It is not clear if similar consistency will be seen in other settings, however, these data suggest that in some settings coverage surveys might be conducted as much as one year following an MDA without compromising results. This might enable integration of post-MDA coverage measurement into large, multipurpose

  3. Accuracy of Coverage Survey Recall following an Integrated Mass Drug Administration for Lymphatic Filariasis, Schistosomiasis, and Soil-Transmitted Helminthiasis.

    Science.gov (United States)

    Budge, Philip J; Sognikin, Edmond; Akosa, Amanda; Mathieu, Els M; Deming, Michael

    2016-01-01

    Achieving target coverage levels for mass drug administration (MDA) is essential to elimination and control efforts for several neglected tropical diseases (NTD). To ensure program goals are met, coverage reported by drug distributors may be validated through household coverage surveys that rely on respondent recall. This is the first study to assess accuracy in such surveys. Recall accuracy was tested in a series of coverage surveys conducted at 1, 6, and 12 months after an integrated MDA in Togo during which three drugs (albendazole, ivermectin, and praziquantel) were distributed. Drug distribution was observed during the MDA to ensure accurate recording of persons treated during the MDA. Information was obtained for 506, 1131, and 947 persons surveyed at 1, 6, and 12 months, respectively. Coverage (defined as the percentage of persons taking at least one of the MDA medications) within these groups was respectively 88.3%, 87.4%, and 80.0%, according to the treatment registers; it was 87.9%, 91.4% and 89.4%, according to survey responses. Concordance between respondents and registers on swallowing at least one pill was >95% at 1 month and >86% at 12 months; the lower concordance at 12 months was more likely due to difficulty matching survey respondents with the year-old treatment register rather than inaccurate responses. Respondents generally distinguished between pills similar in appearance; concordance for recall of which pills were taken was over 80% in each survey. In this population, coverage surveys provided remarkably consistent coverage estimates for up to one year following an integrated MDA. It is not clear if similar consistency will be seen in other settings, however, these data suggest that in some settings coverage surveys might be conducted as much as one year following an MDA without compromising results. This might enable integration of post-MDA coverage measurement into large, multipurpose, periodic surveys, thereby conserving resources.

  4. Accuracy of Coverage Survey Recall following an Integrated Mass Drug Administration for Lymphatic Filariasis, Schistosomiasis, and Soil-Transmitted Helminthiasis.

    Directory of Open Access Journals (Sweden)

    Philip J Budge

    2016-01-01

    Full Text Available Achieving target coverage levels for mass drug administration (MDA is essential to elimination and control efforts for several neglected tropical diseases (NTD. To ensure program goals are met, coverage reported by drug distributors may be validated through household coverage surveys that rely on respondent recall. This is the first study to assess accuracy in such surveys.Recall accuracy was tested in a series of coverage surveys conducted at 1, 6, and 12 months after an integrated MDA in Togo during which three drugs (albendazole, ivermectin, and praziquantel were distributed. Drug distribution was observed during the MDA to ensure accurate recording of persons treated during the MDA. Information was obtained for 506, 1131, and 947 persons surveyed at 1, 6, and 12 months, respectively. Coverage (defined as the percentage of persons taking at least one of the MDA medications within these groups was respectively 88.3%, 87.4%, and 80.0%, according to the treatment registers; it was 87.9%, 91.4% and 89.4%, according to survey responses. Concordance between respondents and registers on swallowing at least one pill was >95% at 1 month and >86% at 12 months; the lower concordance at 12 months was more likely due to difficulty matching survey respondents with the year-old treatment register rather than inaccurate responses. Respondents generally distinguished between pills similar in appearance; concordance for recall of which pills were taken was over 80% in each survey.In this population, coverage surveys provided remarkably consistent coverage estimates for up to one year following an integrated MDA. It is not clear if similar consistency will be seen in other settings, however, these data suggest that in some settings coverage surveys might be conducted as much as one year following an MDA without compromising results. This might enable integration of post-MDA coverage measurement into large, multipurpose, periodic surveys, thereby conserving

  5. High precision mass measurements in Ψ and Υ families revisited

    International Nuclear Information System (INIS)

    Artamonov, A.S.; Baru, S.E.; Blinov, A.E.

    2000-01-01

    High precision mass measurements in Ψ and Υ families performed in 1980-1984 at the VEPP-4 collider with OLYA and MD-1 detectors are revisited. The corrections for the new value of the electron mass are presented. The effect of the updated radiative corrections has been calculated for the J/Ψ(1S) and Ψ(2S) mass measurements [ru

  6. High-sensitivity mass spectrometry with a tandem accelerator

    International Nuclear Information System (INIS)

    Henning, W.

    1984-01-01

    The characteristic features of accelerator mass spectrometry are discussed. A short overview is given of the current status of mass spectrometry with high-energy (MeV/nucleon) heavy-ion accelerators. Emphasis is placed on studies with tandem accelerators and on future mass spectrometry of heavier isotopes with the new generation of higher-voltage tandems

  7. High Accuracy Acoustic Relative Humidity Measurement inDuct Flow with Air

    Directory of Open Access Journals (Sweden)

    Cees van der Geld

    2010-08-01

    Full Text Available An acoustic relative humidity sensor for air-steam mixtures in duct flow is designed and tested. Theory, construction, calibration, considerations on dynamic response and results are presented. The measurement device is capable of measuring line averaged values of gas velocity, temperature and relative humidity (RH instantaneously, by applying two ultrasonic transducers and an array of four temperature sensors. Measurement ranges are: gas velocity of 0–12 m/s with an error of ±0.13 m/s, temperature 0–100 °C with an error of ±0.07 °C and relative humidity 0–100% with accuracy better than 2 % RH above 50 °C. Main advantage over conventional humidity sensors is the high sensitivity at high RH at temperatures exceeding 50 °C, with accuracy increasing with increasing temperature. The sensors are non-intrusive and resist highly humid environments.

  8. High accuracy digital aging monitor based on PLL-VCO circuit

    International Nuclear Information System (INIS)

    Zhang Yuejun; Jiang Zhidi; Wang Pengjun; Zhang Xuelong

    2015-01-01

    As the manufacturing process is scaled down to the nanoscale, the aging phenomenon significantly affects the reliability and lifetime of integrated circuits. Consequently, the precise measurement of digital CMOS aging is a key aspect of nanoscale aging tolerant circuit design. This paper proposes a high accuracy digital aging monitor using phase-locked loop and voltage-controlled oscillator (PLL-VCO) circuit. The proposed monitor eliminates the circuit self-aging effect for the characteristic of PLL, whose frequency has no relationship with circuit aging phenomenon. The PLL-VCO monitor is implemented in TSMC low power 65 nm CMOS technology, and its area occupies 303.28 × 298.94 μm 2 . After accelerating aging tests, the experimental results show that PLL-VCO monitor improves accuracy about high temperature by 2.4% and high voltage by 18.7%. (semiconductor integrated circuits)

  9. High accuracy acoustic relative humidity measurement in duct flow with air.

    Science.gov (United States)

    van Schaik, Wilhelm; Grooten, Mart; Wernaart, Twan; van der Geld, Cees

    2010-01-01

    An acoustic relative humidity sensor for air-steam mixtures in duct flow is designed and tested. Theory, construction, calibration, considerations on dynamic response and results are presented. The measurement device is capable of measuring line averaged values of gas velocity, temperature and relative humidity (RH) instantaneously, by applying two ultrasonic transducers and an array of four temperature sensors. Measurement ranges are: gas velocity of 0-12 m/s with an error of ± 0.13 m/s, temperature 0-100 °C with an error of ± 0.07 °C and relative humidity 0-100% with accuracy better than 2 % RH above 50 °C. Main advantage over conventional humidity sensors is the high sensitivity at high RH at temperatures exceeding 50 °C, with accuracy increasing with increasing temperature. The sensors are non-intrusive and resist highly humid environments.

  10. A proposal for limited criminal liability in high-accuracy endoscopic sinus surgery.

    Science.gov (United States)

    Voultsos, P; Casini, M; Ricci, G; Tambone, V; Midolo, E; Spagnolo, A G

    2017-02-01

    The aim of the present study is to propose legal reform limiting surgeons' criminal liability in high-accuracy and high-risk surgery such as endoscopic sinus surgery (ESS). The study includes a review of the medical literature, focusing on identifying and examining reasons why ESS carries a very high risk of serious complications related to inaccurate surgical manoeuvers and reviewing British and Italian legal theory and case-law on medical negligence, especially with regard to Italian Law 189/2012 (so called "Balduzzi" Law). It was found that serious complications due to inaccurate surgical manoeuvers may occur in ESS regardless of the skill, experience and prudence/diligence of the surgeon. Subjectivity should be essential to medical negligence, especially regarding high-accuracy surgery. Italian Law 189/2012 represents a good basis for the limitation of criminal liability resulting from inaccurate manoeuvres in high-accuracy surgery such as ESS. It is concluded that ESS surgeons should be relieved of criminal liability in cases of simple/ordinary negligence where guidelines have been observed. © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy.

  11. High accuracy Primary Reference gas Mixtures for high-impact greenhouse gases

    Science.gov (United States)

    Nieuwenkamp, Gerard; Zalewska, Ewelina; Pearce-Hill, Ruth; Brewer, Paul; Resner, Kate; Mace, Tatiana; Tarhan, Tanil; Zellweger, Christophe; Mohn, Joachim

    2017-04-01

    Climate change, due to increased man-made emissions of greenhouse gases, poses one of the greatest risks to society worldwide. High-impact greenhouse gases (CO2, CH4 and N2O) and indirect drivers for global warming (e.g. CO) are measured by the global monitoring stations for greenhouse gases, operated and organized by the World Meteorological Organization (WMO). Reference gases for the calibration of analyzers have to meet very challenging low level of measurement uncertainty to comply with the Data Quality Objectives (DQOs) set by the WMO. Within the framework of the European Metrology Research Programme (EMRP), a project to improve the metrology for high-impact greenhouse gases was granted (HIGHGAS, June 2014-May 2017). As a result of the HIGHGAS project, primary reference gas mixtures in cylinders for ambient levels of CO2, CH4, N2O and CO in air have been prepared with unprecedented low uncertainties, typically 3-10 times lower than usually previously achieved by the NMIs. To accomplish these low uncertainties in the reference standards, a number of preparation and analysis steps have been studied and improved. The purity analysis of the parent gases had to be performed with lower detection limits than previously achievable. E.g., to achieve an uncertainty of 2•10-9 mol/mol (absolute) on the amount fraction for N2O, the detection limit for the N2O analysis in the parent gases has to be in the sub nmol/mol domain. Results of an OPO-CRDS analyzer set-up in the 5µm wavelength domain, with a 200•10-12 mol/mol detection limit for N2O, will be presented. The adsorption effects of greenhouse gas components at cylinder surfaces are critical, and have been studied for different cylinder passivation techniques. Results of a two-year stability study will be presented. The fit-for-purpose of the reference materials was studied for possible variation on isotopic composition between the reference material and the sample. Measurement results for a suit of CO2 in air

  12. New perspectives for high accuracy SLR with second generation geodesic satellites

    Science.gov (United States)

    Lund, Glenn

    1993-01-01

    This paper reports on the accuracy limitations imposed by geodesic satellite signatures, and on the potential for achieving millimetric performances by means of alternative satellite concepts and an optimized 2-color system tradeoff. Long distance laser ranging, when performed between a ground (emitter/receiver) station and a distant geodesic satellite, is now reputed to enable short arc trajectory determinations to be achieved with an accuracy of 1 to 2 centimeters. This state-of-the-art accuracy is limited principally by the uncertainties inherent to single-color atmospheric path length correction. Motivated by the study of phenomena such as postglacial rebound, and the detailed analysis of small-scale volcanic and strain deformations, the drive towards millimetric accuracies will inevitably be felt. With the advent of short pulse (less than 50 ps) dual wavelength ranging, combined with adequate detection equipment (such as a fast-scanning streak camera or ultra-fast solid-state detectors) the atmospheric uncertainty could potentially be reduced to the level of a few millimeters, thus, exposing other less significant error contributions, of which by far the most significant will then be the morphology of the retroreflector satellites themselves. Existing geodesic satellites are simply dense spheres, several 10's of cm in diameter, encrusted with a large number (426 in the case of LAGEOS) of small cube-corner reflectors. A single incident pulse, thus, results in a significant number of randomly phased, quasi-simultaneous return pulses. These combine coherently at the receiver to produce a convolved interference waveform which cannot, on a shot to shot basis, be accurately and unambiguously correlated to the satellite center of mass. This paper proposes alternative geodesic satellite concepts, based on the use of a very small number of cube-corner retroreflectors, in which the above difficulties are eliminated while ensuring, for a given emitted pulse, the return

  13. Gene masking - a technique to improve accuracy for cancer classification with high dimensionality in microarray data.

    Science.gov (United States)

    Saini, Harsh; Lal, Sunil Pranit; Naidu, Vimal Vikash; Pickering, Vincel Wince; Singh, Gurmeet; Tsunoda, Tatsuhiko; Sharma, Alok

    2016-12-05

    High dimensional feature space generally degrades classification in several applications. In this paper, we propose a strategy called gene masking, in which non-contributing dimensions are heuristically removed from the data to improve classification accuracy. Gene masking is implemented via a binary encoded genetic algorithm that can be integrated seamlessly with classifiers during the training phase of classification to perform feature selection. It can also be used to discriminate between features that contribute most to the classification, thereby, allowing researchers to isolate features that may have special significance. This technique was applied on publicly available datasets whereby it substantially reduced the number of features used for classification while maintaining high accuracies. The proposed technique can be extremely useful in feature selection as it heuristically removes non-contributing features to improve the performance of classifiers.

  14. High Accuracy Evaluation of the Finite Fourier Transform Using Sampled Data

    Science.gov (United States)

    Morelli, Eugene A.

    1997-01-01

    Many system identification and signal processing procedures can be done advantageously in the frequency domain. A required preliminary step for this approach is the transformation of sampled time domain data into the frequency domain. The analytical tool used for this transformation is the finite Fourier transform. Inaccuracy in the transformation can degrade system identification and signal processing results. This work presents a method for evaluating the finite Fourier transform using cubic interpolation of sampled time domain data for high accuracy, and the chirp Zeta-transform for arbitrary frequency resolution. The accuracy of the technique is demonstrated in example cases where the transformation can be evaluated analytically. Arbitrary frequency resolution is shown to be important for capturing details of the data in the frequency domain. The technique is demonstrated using flight test data from a longitudinal maneuver of the F-18 High Alpha Research Vehicle.

  15. High-Accuracy Spherical Near-Field Measurements for Satellite Antenna Testing

    DEFF Research Database (Denmark)

    Breinbjerg, Olav

    2017-01-01

    The spherical near-field antenna measurement technique is unique in combining several distinct advantages and it generally constitutes the most accurate technique for experimental characterization of radiation from antennas. From the outset in 1970, spherical near-field antenna measurements have...... matured into a well-established technique that is widely used for testing antennas for many wireless applications. In particular, for high-accuracy applications, such as remote sensing satellite missions in ESA's Earth Observation Programme with uncertainty requirements at the level of 0.05dB - 0.10d......B, the spherical near-field antenna measurement technique is generally superior. This paper addresses the means to achieving high measurement accuracy; these include the measurement technique per se, its implementation in terms of proper measurement procedures, the use of uncertainty estimates, as well as facility...

  16. A New Approach to High-accuracy Road Orthophoto Mapping Based on Wavelet Transform

    Directory of Open Access Journals (Sweden)

    Ming Yang

    2011-12-01

    Full Text Available Existing orthophoto map based on satellite photography and aerial photography is not precise enough for road marking. This paper proposes a new approach to high-accuracy orthophoto mapping. The approach uses inverse perspective transformation to process the image information and generates the orthophoto fragment. The offline interpolation algorithm is used to process the location information. It processes the dead reckoning and the EKF location information, and uses the result to transform the fragments to the global coordinate system. At last it uses wavelet transform to divides the image to two frequency bands and uses weighted median algorithm to deal with them separately. The result of experiment shows that the map produced with this method has high accuracy.

  17. High-accuracy dosimetry study for intensity-modulated radiation therapy(IMRT) commissioning

    International Nuclear Information System (INIS)

    Jeong, Hae Sun

    2010-02-01

    Intensity-modulated radiation therapy (IMRT), an advanced modality of high-precision radiotherapy, allows for an increase in dose to the tumor volume without increasing the dose to nearby critical organs. In order to successfully achieve the treatment, intensive dosimetry with accurate dose verification is necessary. A dosimetry for IMRT, however, is a challenging task due to dosimetric ally unfavorable phenomena such as dramatic changes of the dose at the field boundaries, dis-equilibrium of the electrons, non-uniformity between the detector and the phantom materials, and distortion of scanner-read doses. In the present study, therefore, the LEGO-type multi-purpose dosimetry phantom was developed and used for the studies on dose measurements and correction. Phantom materials for muscle, fat, bone, and lung tissue were selected after considering mass density, atomic composition, effective atomic number, and photon interaction coefficients. The phantom also includes dosimeter holders for several different types of detectors including films, which accommodates a construction of different designs of phantoms as necessary. In order to evaluate its performance, the developed phantom was tested by measuring the point dose and the percent depth dose (PDD) for small size fields under several heterogeneous conditions. However, the measurements with the two types of dosimeter did not agree well for the field sizes less than 1 x 1 cm 2 in muscle and bone, and less than 3 x 3 cm 2 in air cavity. Thus, it was recognized that several studies on small fields dosimetry and correction methods for the calculation with a PMCEPT code are needed. The under-estimated values from the ion chamber were corrected with a convolution method employed to eliminate the volume effect of the chamber. As a result, the discrepancies between the EBT film and the ion chamber measurements were significantly decreased, from 14% to 1% (1 x 1 cm 2 ), 10% to 1% (0.7 x 0.7 cm 2 ), and 42% to 7% (0.5 x 0

  18. High-accuracy dosimetry study for intensity-modulated radiation therapy(IMRT) commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Hae Sun

    2010-02-15

    Intensity-modulated radiation therapy (IMRT), an advanced modality of high-precision radiotherapy, allows for an increase in dose to the tumor volume without increasing the dose to nearby critical organs. In order to successfully achieve the treatment, intensive dosimetry with accurate dose verification is necessary. A dosimetry for IMRT, however, is a challenging task due to dosimetric ally unfavorable phenomena such as dramatic changes of the dose at the field boundaries, dis-equilibrium of the electrons, non-uniformity between the detector and the phantom materials, and distortion of scanner-read doses. In the present study, therefore, the LEGO-type multi-purpose dosimetry phantom was developed and used for the studies on dose measurements and correction. Phantom materials for muscle, fat, bone, and lung tissue were selected after considering mass density, atomic composition, effective atomic number, and photon interaction coefficients. The phantom also includes dosimeter holders for several different types of detectors including films, which accommodates a construction of different designs of phantoms as necessary. In order to evaluate its performance, the developed phantom was tested by measuring the point dose and the percent depth dose (PDD) for small size fields under several heterogeneous conditions. However, the measurements with the two types of dosimeter did not agree well for the field sizes less than 1 x 1 cm{sup 2} in muscle and bone, and less than 3 x 3 cm{sup 2} in air cavity. Thus, it was recognized that several studies on small fields dosimetry and correction methods for the calculation with a PMCEPT code are needed. The under-estimated values from the ion chamber were corrected with a convolution method employed to eliminate the volume effect of the chamber. As a result, the discrepancies between the EBT film and the ion chamber measurements were significantly decreased, from 14% to 1% (1 x 1 cm{sup 2}), 10% to 1% (0.7 x 0.7 cm{sup 2}), and 42

  19. High-Precision Mass Measurements of Exotic Nuclei with the Triple-Trap Mass Spectrometer Isoltrap

    CERN Multimedia

    Blaum, K; Zuber, K T; Stanja, J

    2002-01-01

    The masses of close to 200 short-lived nuclides have already been measured with the mass spectrometer ISOLTRAP with a relative precision between 1$\\times$10$^{-7}$ and 1$\\times$10^{-8}$. The installatin of a radio-frequency quadrupole trap increased the overall efficiency by two orders of magnitude which is at present about 1%. In a recent upgrade, we installed a carbon cluster laser ion source, which will allow us to use carbon clusters as mass references for absolute mass measurements. Due to these improvements and the high reliability of ISOLTRAP we are now able to perform accurate high-precision mass measurements all over the nuclear chart. We propose therefore mass measurements on light, medium and heavy nuclides on both sides of the valley of stability in the coming four years. ISOLTRAP is presently the only instrument capable of the high precision required for many of the proposed studies.

  20. Identification and delineation of areas flood hazard using high accuracy of DEM data

    Science.gov (United States)

    Riadi, B.; Barus, B.; Widiatmaka; Yanuar, M. J. P.; Pramudya, B.

    2018-05-01

    Flood incidents that often occur in Karawang regency need to be mitigated. These expectations exist on technologies that can predict, anticipate and reduce disaster risks. Flood modeling techniques using Digital Elevation Model (DEM) data can be applied in mitigation activities. High accuracy DEM data used in modeling, will result in better flooding flood models. The result of high accuracy DEM data processing will yield information about surface morphology which can be used to identify indication of flood hazard area. The purpose of this study was to identify and describe flood hazard areas by identifying wetland areas using DEM data and Landsat-8 images. TerraSAR-X high-resolution data is used to detect wetlands from landscapes, while land cover is identified by Landsat image data. The Topography Wetness Index (TWI) method is used to detect and identify wetland areas with basic DEM data, while for land cover analysis using Tasseled Cap Transformation (TCT) method. The result of TWI modeling yields information about potential land of flood. Overlay TWI map with land cover map that produces information that in Karawang regency the most vulnerable areas occur flooding in rice fields. The spatial accuracy of the flood hazard area in this study was 87%.

  1. High accuracy results for the energy levels of the molecular ions H+2, D+2 and HD+, up to J = 2

    International Nuclear Information System (INIS)

    Karr, J Ph; Hilico, L

    2006-01-01

    We present a nonrelativistic calculation of the rotation-vibration levels of the molecular ions H + 2 , D + 2 and HD + , relying on the diagonalization of the exact three-body Hamiltonian in a variational basis. The J = 2 levels are obtained with a very high accuracy of 10 -14 au (for most levels) representing an improvement by five orders of magnitude over previous calculations. The accuracy is also improved for the J = 1 levels of H + 2 and D + 2 with respect to earlier works. Moreover, we have computed the sensitivities of the energy levels with respect to the mass ratios, allowing these levels to be used for metrological purposes

  2. A Smart High Accuracy Silicon Piezoresistive Pressure Sensor Temperature Compensation System

    Directory of Open Access Journals (Sweden)

    Guanwu Zhou

    2014-07-01

    Full Text Available Theoretical analysis in this paper indicates that the accuracy of a silicon piezoresistive pressure sensor is mainly affected by thermal drift, and varies nonlinearly with the temperature. Here, a smart temperature compensation system to reduce its effect on accuracy is proposed. Firstly, an effective conditioning circuit for signal processing and data acquisition is designed. The hardware to implement the system is fabricated. Then, a program is developed on LabVIEW which incorporates an extreme learning machine (ELM as the calibration algorithm for the pressure drift. The implementation of the algorithm was ported to a micro-control unit (MCU after calibration in the computer. Practical pressure measurement experiments are carried out to verify the system’s performance. The temperature compensation is solved in the interval from −40 to 85 °C. The compensated sensor is aimed at providing pressure measurement in oil-gas pipelines. Compared with other algorithms, ELM acquires higher accuracy and is more suitable for batch compensation because of its higher generalization and faster learning speed. The accuracy, linearity, zero temperature coefficient and sensitivity temperature coefficient of the tested sensor are 2.57% FS, 2.49% FS, 8.1 × 10−5/°C and 29.5 × 10−5/°C before compensation, and are improved to 0.13%FS, 0.15%FS, 1.17 × 10−5/°C and 2.1 × 10−5/°C respectively, after compensation. The experimental results demonstrate that the proposed system is valid for the temperature compensation and high accuracy requirement of the sensor.

  3. Biomarker discovery in high grade sarcomas by mass spectrometry imaging

    OpenAIRE

    Lou, S.

    2017-01-01

    This thesis demonstrates a detailed biomarker discovery Mass Spectrometry Imaging workflow for histologically heterogeneous high grade sarcomas. Panels of protein and metabolite signatures were discovered either distinguishing different histological subtypes or stratifying high risk patients with poor survival.

  4. Accuracy of Bioelectrical Impedance Analysis in Estimated Longitudinal Fat-Free Mass Changes in Male Army Cadets.

    Science.gov (United States)

    Langer, Raquel D; Matias, Catarina N; Borges, Juliano H; Cirolini, Vagner X; Páscoa, Mauro A; Guerra-Júnior, Gil; Gonçalves, Ezequiel M

    2018-03-26

    Bioelectrical impedance analysis (BIA) is a practical and rapid method for making a longitudinal analysis of changes in body composition. However, most BIA validation studies have been performed in a clinical population and only at one moment, or point in time (cross-sectional study). The aim of this study is to investigate the accuracy of predictive equations based on BIA with regard to the changes in fat-free mass (FFM) in Brazilian male army cadets after 7 mo of military training. The values used were determined using dual-energy X-ray absorptiometry (DXA) as a reference method. The study included 310 male Brazilian Army cadets (aged 17-24 yr). FFM was measured using eight general predictive BIA equations, with one equation specifically applied to this population sample, and the values were compared with results obtained using DXA. The student's t-test, adjusted coefficient of determination (R2), standard error of estimation (SEE), Lin's approach, and the Bland-Altman test were used to determine the accuracy of the predictive BIA equations used to estimate FFM in this population and between the two moments (pre- and post-moment). The FFM measured using the nine predictive BIA equations, and determined using DXA at the post-moment, showed a significant increase when compared with the pre-moment (p FFM changes in the army cadets between the two moments in a very similar way to the reference method (DXA). However, only the one BIA equation specific to this population showed no significant differences in the FFM estimation between DXA at pre- and post-moment of military routine. All predictive BIA equations showed large limits of agreement using the Bland-Altman approach. The eight general predictive BIA equations used in this study were not found to be valid for analyzing the FFM changes in the Brazilian male army cadets, after a period of approximately 7 mo of military training. Although the BIA equation specific to this population is dependent on the amount of

  5. High accuracy and precision micro injection moulding of thermoplastic elastomers micro ring production

    DEFF Research Database (Denmark)

    Calaon, Matteo; Tosello, Guido; Elsborg, René

    2016-01-01

    The mass-replication nature of the process calls for fast monitoring of process parameters and product geometrical characteristics. In this direction, the present study addresses the possibility to develop a micro manufacturing platform for micro assembly injection moulding with real-time process....../product monitoring and metrology. The study represent a new concept yet to be developed with great potential for high precision mass-manufacturing of highly functional 3D multi-material (i.e. including metal/soft polymer) micro components. The activities related to HINMICO project objectives proves the importance...

  6. Optical System Error Analysis and Calibration Method of High-Accuracy Star Trackers

    Directory of Open Access Journals (Sweden)

    Zheng You

    2013-04-01

    Full Text Available The star tracker is a high-accuracy attitude measurement device widely used in spacecraft. Its performance depends largely on the precision of the optical system parameters. Therefore, the analysis of the optical system parameter errors and a precise calibration model are crucial to the accuracy of the star tracker. Research in this field is relatively lacking a systematic and universal analysis up to now. This paper proposes in detail an approach for the synthetic error analysis of the star tracker, without the complicated theoretical derivation. This approach can determine the error propagation relationship of the star tracker, and can build intuitively and systematically an error model. The analysis results can be used as a foundation and a guide for the optical design, calibration, and compensation of the star tracker. A calibration experiment is designed and conducted. Excellent calibration results are achieved based on the calibration model. To summarize, the error analysis approach and the calibration method are proved to be adequate and precise, and could provide an important guarantee for the design, manufacture, and measurement of high-accuracy star trackers.

  7. Optical system error analysis and calibration method of high-accuracy star trackers.

    Science.gov (United States)

    Sun, Ting; Xing, Fei; You, Zheng

    2013-04-08

    The star tracker is a high-accuracy attitude measurement device widely used in spacecraft. Its performance depends largely on the precision of the optical system parameters. Therefore, the analysis of the optical system parameter errors and a precise calibration model are crucial to the accuracy of the star tracker. Research in this field is relatively lacking a systematic and universal analysis up to now. This paper proposes in detail an approach for the synthetic error analysis of the star tracker, without the complicated theoretical derivation. This approach can determine the error propagation relationship of the star tracker, and can build intuitively and systematically an error model. The analysis results can be used as a foundation and a guide for the optical design, calibration, and compensation of the star tracker. A calibration experiment is designed and conducted. Excellent calibration results are achieved based on the calibration model. To summarize, the error analysis approach and the calibration method are proved to be adequate and precise, and could provide an important guarantee for the design, manufacture, and measurement of high-accuracy star trackers.

  8. Implementation of High Time Delay Accuracy of Ultrasonic Phased Array Based on Interpolation CIC Filter.

    Science.gov (United States)

    Liu, Peilu; Li, Xinghua; Li, Haopeng; Su, Zhikun; Zhang, Hongxu

    2017-10-12

    In order to improve the accuracy of ultrasonic phased array focusing time delay, analyzing the original interpolation Cascade-Integrator-Comb (CIC) filter, an 8× interpolation CIC filter parallel algorithm was proposed, so that interpolation and multichannel decomposition can simultaneously process. Moreover, we summarized the general formula of arbitrary multiple interpolation CIC filter parallel algorithm and established an ultrasonic phased array focusing time delay system based on 8× interpolation CIC filter parallel algorithm. Improving the algorithmic structure, 12.5% of addition and 29.2% of multiplication was reduced, meanwhile the speed of computation is still very fast. Considering the existing problems of the CIC filter, we compensated the CIC filter; the compensated CIC filter's pass band is flatter, the transition band becomes steep, and the stop band attenuation increases. Finally, we verified the feasibility of this algorithm on Field Programming Gate Array (FPGA). In the case of system clock is 125 MHz, after 8× interpolation filtering and decomposition, time delay accuracy of the defect echo becomes 1 ns. Simulation and experimental results both show that the algorithm we proposed has strong feasibility. Because of the fast calculation, small computational amount and high resolution, this algorithm is especially suitable for applications with high time delay accuracy and fast detection.

  9. Implementation of High Time Delay Accuracy of Ultrasonic Phased Array Based on Interpolation CIC Filter

    Directory of Open Access Journals (Sweden)

    Peilu Liu

    2017-10-01

    Full Text Available In order to improve the accuracy of ultrasonic phased array focusing time delay, analyzing the original interpolation Cascade-Integrator-Comb (CIC filter, an 8× interpolation CIC filter parallel algorithm was proposed, so that interpolation and multichannel decomposition can simultaneously process. Moreover, we summarized the general formula of arbitrary multiple interpolation CIC filter parallel algorithm and established an ultrasonic phased array focusing time delay system based on 8× interpolation CIC filter parallel algorithm. Improving the algorithmic structure, 12.5% of addition and 29.2% of multiplication was reduced, meanwhile the speed of computation is still very fast. Considering the existing problems of the CIC filter, we compensated the CIC filter; the compensated CIC filter’s pass band is flatter, the transition band becomes steep, and the stop band attenuation increases. Finally, we verified the feasibility of this algorithm on Field Programming Gate Array (FPGA. In the case of system clock is 125 MHz, after 8× interpolation filtering and decomposition, time delay accuracy of the defect echo becomes 1 ns. Simulation and experimental results both show that the algorithm we proposed has strong feasibility. Because of the fast calculation, small computational amount and high resolution, this algorithm is especially suitable for applications with high time delay accuracy and fast detection.

  10. High-accuracy determination of the neutron flux at n{sub T}OF

    Energy Technology Data Exchange (ETDEWEB)

    Barbagallo, M.; Colonna, N.; Mastromarco, M.; Meaze, M.; Tagliente, G.; Variale, V. [Sezione di Bari, INFN, Bari (Italy); Guerrero, C.; Andriamonje, S.; Boccone, V.; Brugger, M.; Calviani, M.; Cerutti, F.; Chin, M.; Ferrari, A.; Kadi, Y.; Losito, R.; Versaci, R.; Vlachoudis, V. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Tsinganis, A. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); National Technical University of Athens (NTUA), Athens (Greece); Tarrio, D.; Duran, I.; Leal-Cidoncha, E.; Paradela, C. [Universidade de Santiago de Compostela, Santiago (Spain); Altstadt, S.; Goebel, K.; Langer, C.; Reifarth, R.; Schmidt, S.; Weigand, M. [Johann-Wolfgang-Goethe Universitaet, Frankfurt (Germany); Andrzejewski, J.; Marganiec, J.; Perkowski, J. [Uniwersytet Lodzki, Lodz (Poland); Audouin, L.; Leong, L.S.; Tassan-Got, L. [Centre National de la Recherche Scientifique/IN2P3 - IPN, Orsay (France); Becares, V.; Cano-Ott, D.; Garcia, A.R.; Gonzalez-Romero, E.; Martinez, T.; Mendoza, E. [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain); Becvar, F.; Krticka, M.; Kroll, J.; Valenta, S. [Charles University, Prague (Czech Republic); Belloni, F.; Fraval, K.; Gunsing, F.; Lampoudis, C.; Papaevangelou, T. [Commissariata l' Energie Atomique (CEA) Saclay - Irfu, Gif-sur-Yvette (France); Berthoumieux, E.; Chiaveri, E. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Commissariata l' Energie Atomique (CEA) Saclay - Irfu, Gif-sur-Yvette (France); Billowes, J.; Ware, T.; Wright, T. [University of Manchester, Manchester (United Kingdom); Bosnar, D.; Zugec, P. [University of Zagreb, Department of Physics, Faculty of Science, Zagreb (Croatia); Calvino, F.; Cortes, G.; Gomez-Hornillos, M.B.; Riego, A. [Universitat Politecnica de Catalunya, Barcelona (Spain); Carrapico, C.; Goncalves, I.F.; Sarmento, R.; Vaz, P. [Universidade Tecnica de Lisboa, Instituto Tecnologico e Nuclear, Instituto Superior Tecnico, Lisboa (Portugal); Cortes-Giraldo, M.A.; Praena, J.; Quesada, J.M.; Sabate-Gilarte, M. [Universidad de Sevilla, Sevilla (Spain); Diakaki, M.; Karadimos, D.; Kokkoris, M.; Vlastou, R. [National Technical University of Athens (NTUA), Athens (Greece); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L. [CSIC-Universidad de Valencia, Instituto de Fisica Corpuscular, Valencia (Spain); Dressler, R.; Kivel, N.; Schumann, D.; Steinegger, P. [Paul Scherrer Institut, Villigen PSI (Switzerland); Dzysiuk, N.; Mastinu, P.F. [Laboratori Nazionali di Legnaro, INFN, Rome (Italy); Eleftheriadis, C.; Manousos, A. [Aristotle University of Thessaloniki, Thessaloniki (Greece); Ganesan, S.; Gurusamy, P.; Saxena, A. [Bhabha Atomic Research Centre (BARC), Mumbai (IN); Griesmayer, E.; Jericha, E.; Leeb, H. [Technische Universitaet Wien, Atominstitut, Wien (AT); Hernandez-Prieto, A. [European Organization for Nuclear Research (CERN), Geneva (CH); Universitat Politecnica de Catalunya, Barcelona (ES); Jenkins, D.G.; Vermeulen, M.J. [University of York, Heslington, York (GB); Kaeppeler, F. [Institut fuer Kernphysik, Karlsruhe Institute of Technology, Campus Nord, Karlsruhe (DE); Koehler, P. [Oak Ridge National Laboratory (ORNL), Oak Ridge (US); Lederer, C. [Johann-Wolfgang-Goethe Universitaet, Frankfurt (DE); University of Vienna, Faculty of Physics, Vienna (AT); Massimi, C.; Mingrone, F.; Vannini, G. [Universita di Bologna (IT); INFN, Sezione di Bologna, Dipartimento di Fisica, Bologna (IT); Mengoni, A.; Ventura, A. [Agenzia nazionale per le nuove tecnologie, l' energia e lo sviluppo economico sostenibile (ENEA), Bologna (IT); Milazzo, P.M. [Sezione di Trieste, INFN, Trieste (IT); Mirea, M. [Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH, Bucharest - Magurele (RO); Mondalaers, W.; Plompen, A.; Schillebeeckx, P. [Institute for Reference Materials and Measurements, European Commission JRC, Geel (BE); Pavlik, A.; Wallner, A. [University of Vienna, Faculty of Physics, Vienna (AT); Rauscher, T. [University of Basel, Department of Physics and Astronomy, Basel (CH); Roman, F. [European Organization for Nuclear Research (CERN), Geneva (CH); Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH, Bucharest - Magurele (RO); Rubbia, C. [European Organization for Nuclear Research (CERN), Geneva (CH); Laboratori Nazionali del Gran Sasso dell' INFN, Assergi (AQ) (IT); Weiss, C. [European Organization for Nuclear Research (CERN), Geneva (CH); Johann-Wolfgang-Goethe Universitaet, Frankfurt (DE)

    2013-12-15

    The neutron flux of the n{sub T}OF facility at CERN was measured, after installation of the new spallation target, with four different systems based on three neutron-converting reactions, which represent accepted cross sections standards in different energy regions. A careful comparison and combination of the different measurements allowed us to reach an unprecedented accuracy on the energy dependence of the neutron flux in the very wide range (thermal to 1 GeV) that characterizes the n{sub T}OF neutron beam. This is a pre-requisite for the high accuracy of cross section measurements at n{sub T}OF. An unexpected anomaly in the neutron-induced fission cross section of {sup 235}U is observed in the energy region between 10 and 30keV, hinting at a possible overestimation of this important cross section, well above currently assigned uncertainties. (orig.)

  11. Fission product model for BWR analysis with improved accuracy in high burnup

    International Nuclear Information System (INIS)

    Ikehara, Tadashi; Yamamoto, Munenari; Ando, Yoshihira

    1998-01-01

    A new fission product (FP) chain model has been studied to be used in a BWR lattice calculation. In attempting to establish the model, two requirements, i.e. the accuracy in predicting burnup reactivity and the easiness in practical application, are simultaneously considered. The resultant FP model consists of 81 explicit FP nuclides and two lumped pseudo nuclides having the absorption cross sections independent of burnup history and fuel composition. For the verification, extensive numerical tests covering over a wide range of operational conditions and fuel compositions have been carried out. The results indicate that the estimated errors in burnup reactivity are within 0.1%Δk for exposures up to 100GWd/t. It is concluded that the present model can offer a high degree of accuracy for FP representation in BWR lattice calculation. (author)

  12. High Accuracy Attitude Control System Design for Satellite with Flexible Appendages

    Directory of Open Access Journals (Sweden)

    Wenya Zhou

    2014-01-01

    Full Text Available In order to realize the high accuracy attitude control of satellite with flexible appendages, attitude control system consisting of the controller and structural filter was designed. When the low order vibration frequency of flexible appendages is approximating the bandwidth of attitude control system, the vibration signal will enter the control system through measurement device to bring impact on the accuracy or even the stability. In order to reduce the impact of vibration of appendages on the attitude control system, the structural filter is designed in terms of rejecting the vibration of flexible appendages. Considering the potential problem of in-orbit frequency variation of the flexible appendages, the design method for the adaptive notch filter is proposed based on the in-orbit identification technology. Finally, the simulation results are given to demonstrate the feasibility and effectiveness of the proposed design techniques.

  13. High-accuracy numerical integration of charged particle motion – with application to ponderomotive force

    International Nuclear Information System (INIS)

    Furukawa, Masaru; Ohkawa, Yushiro; Matsuyama, Akinobu

    2016-01-01

    A high-accuracy numerical integration algorithm for a charged particle motion is developed. The algorithm is based on the Hamiltonian mechanics and the operator decomposition. The algorithm is made to be time-reversal symmetric, and its order of accuracy can be increased to any order by using a recurrence formula. One of the advantages is that it is an explicit method. An effective way to decompose the time evolution operator is examined; the Poisson tensor is decomposed and non-canonical variables are adopted. The algorithm is extended to a time dependent fields' case by introducing the extended phase space. Numerical tests showing the performance of the algorithm are presented. One is the pure cyclotron motion for a long time period, and the other is a charged particle motion in a rapidly oscillating field. (author)

  14. High-accuracy defect sizing for CRDM penetration adapters using the ultrasonic TOFD technique

    International Nuclear Information System (INIS)

    Atkinson, I.

    1995-01-01

    Ultrasonic time-of-flight diffraction (TOFD) is the preferred technique for critical sizing of throughwall orientated defects in a wide range of components, primarily because it is intrinsically more accurate than amplitude-based techniques. For the same reason, TOFD is the preferred technique for sizing the cracks in control rod drive mechanism (CRDM) penetration adapters, which have been the subject of much recent attention. Once the considerable problem of restricted access for the UT probes has been overcome, this inspection lends itself to very high accuracy defect sizing using TOFD. In qualification trials under industrial conditions, depth sizing to an accuracy of ≤ 0.5 mm has been routinely achieved throughout the full wall thickness (16 mm) of the penetration adapters, using only a single probe pair and without recourse to signal processing. (author)

  15. CONSTRAINTS ON THE RELATIONSHIP BETWEEN STELLAR MASS AND HALO MASS AT LOW AND HIGH REDSHIFT

    International Nuclear Information System (INIS)

    Moster, Benjamin P.; Somerville, Rachel S.; Maulbetsch, Christian; Van den Bosch, Frank C.; Maccio, Andrea V.; Naab, Thorsten; Oser, Ludwig

    2010-01-01

    We use a statistical approach to determine the relationship between the stellar masses of galaxies and the masses of the dark matter halos in which they reside. We obtain a parameterized stellar-to-halo mass (SHM) relation by populating halos and subhalos in an N-body simulation with galaxies and requiring that the observed stellar mass function be reproduced. We find good agreement with constraints from galaxy-galaxy lensing and predictions of semi-analytic models. Using this mapping, and the positions of the halos and subhalos obtained from the simulation, we find that our model predictions for the galaxy two-point correlation function (CF) as a function of stellar mass are in excellent agreement with the observed clustering properties in the Sloan Digital Sky Survey at z = 0. We show that the clustering data do not provide additional strong constraints on the SHM function and conclude that our model can therefore predict clustering as a function of stellar mass. We compute the conditional mass function, which yields the average number of galaxies with stellar masses in the range m ± dm/2 that reside in a halo of mass M. We study the redshift dependence of the SHM relation and show that, for low-mass halos, the SHM ratio is lower at higher redshift. The derived SHM relation is used to predict the stellar mass dependent galaxy CF and bias at high redshift. Our model predicts that not only are massive galaxies more biased than low-mass galaxies at all redshifts, but also the bias increases more rapidly with increasing redshift for massive galaxies than for low-mass ones. We present convenient fitting functions for the SHM relation as a function of redshift, the conditional mass function, and the bias as a function of stellar mass and redshift.

  16. High accuracy of family history of melanoma in Danish melanoma cases

    DEFF Research Database (Denmark)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-01-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor...... but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma...

  17. Automation, Operation, and Data Analysis in the Cryogenic, High Accuracy, Refraction Measuring System (CHARMS)

    Science.gov (United States)

    Frey, Bradley J.; Leviton, Douglas B.

    2005-01-01

    The Cryogenic High Accuracy Refraction Measuring System (CHARMS) at NASA's Goddard Space Flight Center has been enhanced in a number of ways in the last year to allow the system to accurately collect refracted beam deviation readings automatically over a range of temperatures from 15 K to well beyond room temperature with high sampling density in both wavelength and temperature. The engineering details which make this possible are presented. The methods by which the most accurate angular measurements are made and the corresponding data reduction methods used to reduce thousands of observed angles to a handful of refractive index values are also discussed.

  18. Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease

    Science.gov (United States)

    Herrera, VM; Casas, JP; Miranda, JJ; Perel, P; Pichardo, R; González, A; Sanchez, JR; Ferreccio, C; Aguilera, X; Silva, E; Oróstegui, M; Gómez, LF; Chirinos, JA; Medina-Lezama, J; Pérez, CM; Suárez, E; Ortiz, AP; Rosero, L; Schapochnik, N; Ortiz, Z; Ferrante, D; Diaz, M; Bautista, LE

    2009-01-01

    Background Cut points for defining obesity have been derived from mortality data among Whites from Europe and the United States and their accuracy to screen for high risk of coronary heart disease (CHD) in other ethnic groups has been questioned. Objective To compare the accuracy and to define ethnic and gender-specific optimal cut points for body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) when they are used in screening for high risk of CHD in the Latin-American and the US populations. Methods We estimated the accuracy and optimal cut points for BMI, WC and WHR to screen for CHD risk in Latin Americans (n=18 976), non-Hispanic Whites (Whites; n=8956), non-Hispanic Blacks (Blacks; n=5205) and Hispanics (n=5803). High risk of CHD was defined as a 10-year risk ≥20% (Framingham equation). The area under the receiver operator characteristic curve (AUC) and the misclassification-cost term were used to assess accuracy and to identify optimal cut points. Results WHR had the highest AUC in all ethnic groups (from 0.75 to 0.82) and BMI had the lowest (from 0.50 to 0.59). Optimal cut point for BMI was similar across ethnic/gender groups (27 kg/m2). In women, cut points for WC (94 cm) and WHR (0.91) were consistent by ethnicity. In men, cut points for WC and WHR varied significantly with ethnicity: from 91 cm in Latin Americans to 102 cm in Whites, and from 0.94 in Latin Americans to 0.99 in Hispanics, respectively. Conclusion WHR is the most accurate anthropometric indicator to screen for high risk of CHD, whereas BMI is almost uninformative. The same BMI cut point should be used in all men and women. Unique cut points for WC and WHR should be used in all women, but ethnic-specific cut points seem warranted among men. PMID:19238159

  19. High-Accuracy Elevation Data at Large Scales from Airborne Single-Pass SAR Interferometry

    Directory of Open Access Journals (Sweden)

    Guy Jean-Pierre Schumann

    2016-01-01

    Full Text Available Digital elevation models (DEMs are essential data sets for disaster risk management and humanitarian relief services as well as many environmental process models. At present, on the hand, globally available DEMs only meet the basic requirements and for many services and modeling studies are not of high enough spatial resolution and lack accuracy in the vertical. On the other hand, LiDAR-DEMs are of very high spatial resolution and great vertical accuracy but acquisition operations can be very costly for spatial scales larger than a couple of hundred square km and also have severe limitations in wetland areas and under cloudy and rainy conditions. The ideal situation would thus be to have a DEM technology that allows larger spatial coverage than LiDAR but without compromising resolution and vertical accuracy and still performing under some adverse weather conditions and at a reasonable cost. In this paper, we present a novel single pass In-SAR technology for airborne vehicles that is cost-effective and can generate DEMs with a vertical error of around 0.3 m for an average spatial resolution of 3 m. To demonstrate this capability, we compare a sample single-pass In-SAR Ka-band DEM of the California Central Valley from the NASA/JPL airborne GLISTIN-A to a high-resolution LiDAR DEM. We also perform a simple sensitivity analysis to floodplain inundation. Based on the findings of our analysis, we argue that this type of technology can and should be used to replace large regions of globally available lower resolution DEMs, particularly in coastal, delta and floodplain areas where a high number of assets, habitats and lives are at risk from natural disasters. We conclude with a discussion on requirements, advantages and caveats in terms of instrument and data processing.

  20. Accuracy of cell calculation methods used for analysis of high conversion light water reactor lattice

    International Nuclear Information System (INIS)

    Jeong, Chang-Joon; Okumura, Keisuke; Ishiguro, Yukio; Tanaka, Ken-ichi

    1990-01-01

    Validation tests were made for the accuracy of cell calculation methods used in analyses of tight lattices of a mixed-oxide (MOX) fuel core in a high conversion light water reactor (HCLWR). A series of cell calculations was carried out for the lattices referred from an international HCLWR benchmark comparison, with emphasis placed on the resonance calculation methods; the NR, IR approximations, the collision probability method with ultra-fine energy group. Verification was also performed for the geometrical modelling; a hexagonal/cylindrical cell, and the boundary condition; mirror/white reflection. In the calculations, important reactor physics parameters, such as the neutron multiplication factor, the conversion ratio and the void coefficient, were evaluated using the above methods for various HCLWR lattices with different moderator to fuel volume ratios, fuel materials and fissile plutonium enrichments. The calculated results were compared with each other, and the accuracy and applicability of each method were clarified by comparison with continuous energy Monte Carlo calculations. It was verified that the accuracy of the IR approximation became worse when the neutron spectrum became harder. It was also concluded that the cylindrical cell model with the white boundary condition was not so suitable for MOX fuelled lattices, as for UO 2 fuelled lattices. (author)

  1. Accuracy of High-Resolution Ultrasonography in the Detection of Extensor Tendon Lacerations.

    Science.gov (United States)

    Dezfuli, Bobby; Taljanovic, Mihra S; Melville, David M; Krupinski, Elizabeth A; Sheppard, Joseph E

    2016-02-01

    Lacerations to the extensor mechanism are usually diagnosed clinically. Ultrasound (US) has been a growing diagnostic tool for tendon injuries since the 1990s. To date, there has been no publication establishing the accuracy and reliability of US in the evaluation of extensor mechanism lacerations in the hand. The purpose of this study is to determine the accuracy of US to detect extensor tendon injuries in the hand. Sixteen fingers and 4 thumbs in 4 fresh-frozen and thawed cadaveric hands were used. Sixty-eight 0.5-cm transverse skin lacerations were created. Twenty-seven extensor tendons were sharply transected. The remaining skin lacerations were used as sham dissection controls. One US technologist and one fellowship-trained musculoskeletal radiologist performed real-time dynamic US studies in and out of water bath. A second fellowship trained musculoskeletal radiologist subsequently reviewed the static US images. Dynamic and static US interpretation accuracy was assessed using dissection as "truth." All 27 extensor tendon lacerations and controls were identified correctly with dynamic imaging as either injury models that had a transected extensor tendon or sham controls with intact extensor tendons (sensitivity = 100%, specificity = 100%, positive predictive value = 1.0; all significantly greater than chance). Static imaging had a sensitivity of 85%, specificity of 89%, and accuracy of 88% (all significantly greater than chance). The results of the dynamic real time versus static US imaging were clearly different but did not reach statistical significance. Diagnostic US is a very accurate noninvasive study that can identify extensor mechanism injuries. Clinically suspected cases of acute extensor tendon injury scanned by high-frequency US can aid and/or confirm the diagnosis, with dynamic imaging providing added value compared to static. Ultrasonography, to aid in the diagnosis of extensor mechanism lacerations, can be successfully used in a reliable and

  2. Accuracy assessment of high frequency 3D ultrasound for digital impression-taking of prepared teeth

    Science.gov (United States)

    Heger, Stefan; Vollborn, Thorsten; Tinschert, Joachim; Wolfart, Stefan; Radermacher, Klaus

    2013-03-01

    Silicone based impression-taking of prepared teeth followed by plaster casting is well-established but potentially less reliable, error-prone and inefficient, particularly in combination with emerging techniques like computer aided design and manufacturing (CAD/CAM) of dental prosthesis. Intra-oral optical scanners for digital impression-taking have been introduced but until now some drawbacks still exist. Because optical waves can hardly penetrate liquids or soft-tissues, sub-gingival preparations still need to be uncovered invasively prior to scanning. High frequency ultrasound (HFUS) based micro-scanning has been recently investigated as an alternative to optical intra-oral scanning. Ultrasound is less sensitive against oral fluids and in principal able to penetrate gingiva without invasively exposing of sub-gingival preparations. Nevertheless, spatial resolution as well as digitization accuracy of an ultrasound based micro-scanning system remains a critical parameter because the ultrasound wavelength in water-like media such as gingiva is typically smaller than that of optical waves. In this contribution, the in-vitro accuracy of ultrasound based micro-scanning for tooth geometry reconstruction is being investigated and compared to its extra-oral optical counterpart. In order to increase the spatial resolution of the system, 2nd harmonic frequencies from a mechanically driven focused single element transducer were separated and corresponding 3D surface models were calculated for both fundamentals and 2nd harmonics. Measurements on phantoms, model teeth and human teeth were carried out for evaluation of spatial resolution and surface detection accuracy. Comparison of optical and ultrasound digital impression taking indicate that, in terms of accuracy, ultrasound based tooth digitization can be an alternative for optical impression-taking.

  3. Technical accuracy of a neuronavigation system measured with a high-precision mechanical micromanipulator.

    Science.gov (United States)

    Kaus, M; Steinmeier, R; Sporer, T; Ganslandt, O; Fahlbusch, R

    1997-12-01

    This study was designed to determine and evaluate the different system-inherent sources of erroneous target localization of a light-emitting diode (LED)-based neuronavigation system (StealthStation, Stealth Technologies, Boulder, CO). The localization accuracy was estimated by applying a high-precision mechanical micromanipulator to move and exactly locate (+/- 0.1 micron) the pointer at multiple positions in the physical three-dimensional space. The localization error was evaluated by calculating the spatial distance between the (known) LED positions and the LED coordinates measured by the neuronavigator. The results are based on a study of approximately 280,000 independent coordinate measurements. The maximum localization error detected was 0.55 +/- 0.29 mm, with the z direction (distance to the camera array) being the most erroneous coordinate. Minimum localization error was found at a distance of 1400 mm from the central camera (optimal measurement position). Additional error due to 1) mechanical vibrations of the camera tripod (+/- 0.15 mm) and the reference frame (+/- 0.08 mm) and 2) extrapolation of the pointer tip position from the LED coordinates of at least +/- 0.12 mm were detected, leading to a total technical error of 0.55 +/- 0.64 mm. Based on this technical accuracy analysis, a set of handling recommendations is proposed, leading to an improved localization accuracy. The localization error could be reduced by 0.3 +/- 0.15 mm by correct camera positioning (1400 mm distance) plus 0.15 mm by vibration-eliminating fixation of the camera. Correct handling of the probe during the operation may improve the accuracy by up to 0.1 mm.

  4. Challenges in high accuracy surface replication for micro optics and micro fluidics manufacture

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard; Calaon, Matteo

    2014-01-01

    Patterning the surface of polymer components with microstructured geometries is employed in optical and microfluidic applications. Mass fabrication of polymer micro structured products is enabled by replication technologies such as injection moulding. Micro structured tools are also produced...... by replication technologies such as nickel electroplating. All replication steps are enabled by a high precision master and high reproduction fidelity to ensure that the functionalities associated with the design are transferred to the final component. Engineered surface micro structures can be either...

  5. Broadband EIT borehole measurements with high phase accuracy using numerical corrections of electromagnetic coupling effects

    International Nuclear Information System (INIS)

    Zhao, Y; Zimmermann, E; Wolters, B; Van Waasen, S; Huisman, J A; Treichel, A; Kemna, A

    2013-01-01

    Electrical impedance tomography (EIT) is gaining importance in the field of geophysics and there is increasing interest for accurate borehole EIT measurements in a broad frequency range (mHz to kHz) in order to study subsurface properties. To characterize weakly polarizable soils and sediments with EIT, high phase accuracy is required. Typically, long electrode cables are used for borehole measurements. However, this may lead to undesired electromagnetic coupling effects associated with the inductive coupling between the double wire pairs for current injection and potential measurement and the capacitive coupling between the electrically conductive shield of the cable and the electrically conductive environment surrounding the electrode cables. Depending on the electrical properties of the subsurface and the measured transfer impedances, both coupling effects can cause large phase errors that have typically limited the frequency bandwidth of field EIT measurements to the mHz to Hz range. The aim of this paper is to develop numerical corrections for these phase errors. To this end, the inductive coupling effect was modeled using electronic circuit models, and the capacitive coupling effect was modeled by integrating discrete capacitances in the electrical forward model describing the EIT measurement process. The correction methods were successfully verified with measurements under controlled conditions in a water-filled rain barrel, where a high phase accuracy of 0.8 mrad in the frequency range up to 10 kHz was achieved. The corrections were also applied to field EIT measurements made using a 25 m long EIT borehole chain with eight electrodes and an electrode separation of 1 m. The results of a 1D inversion of these measurements showed that the correction methods increased the measurement accuracy considerably. It was concluded that the proposed correction methods enlarge the bandwidth of the field EIT measurement system, and that accurate EIT measurements can now

  6. An angle encoder for super-high resolution and super-high accuracy using SelfA

    Science.gov (United States)

    Watanabe, Tsukasa; Kon, Masahito; Nabeshima, Nobuo; Taniguchi, Kayoko

    2014-06-01

    Angular measurement technology at high resolution for applications such as in hard disk drive manufacturing machines, precision measurement equipment and aspherical process machines requires a rotary encoder with high accuracy, high resolution and high response speed. However, a rotary encoder has angular deviation factors during operation due to scale error or installation error. It has been assumed to be impossible to achieve accuracy below 0.1″ in angular measurement or control after the installation onto the rotating axis. Self-calibration (Lu and Trumper 2007 CIRP Ann. 56 499; Kim et al 2011 Proc. MacroScale; Probst 2008 Meas. Sci. Technol. 19 015101; Probst et al Meas. Sci. Technol. 9 1059; Tadashi and Makoto 1993 J. Robot. Mechatronics 5 448; Ralf et al 2006 Meas. Sci. Technol. 17 2811) and cross-calibration (Probst et al 1998 Meas. Sci. Technol. 9 1059; Just et al 2009 Precis. Eng. 33 530; Burnashev 2013 Quantum Electron. 43 130) technologies for a rotary encoder have been actively discussed on the basis of the principle of circular closure. This discussion prompted the development of rotary tables which achieve reliable and high accuracy angular verification. We apply these technologies for the development of a rotary encoder not only to meet the requirement of super-high accuracy but also to meet that of super-high resolution. This paper presents the development of an encoder with 221 = 2097 152 resolutions per rotation (360°), that is, corresponding to a 0.62″ signal period, achieved by the combination of a laser rotary encoder supplied by Magnescale Co., Ltd and a self-calibratable encoder (SelfA) supplied by The National Institute of Advanced Industrial Science & Technology (AIST). In addition, this paper introduces the development of a rotary encoder to guarantee ±0.03″ accuracy at any point of the interpolated signal, with respect to the encoder at the minimum resolution of 233, that is, corresponding to a 0.0015″ signal period after

  7. An angle encoder for super-high resolution and super-high accuracy using SelfA

    International Nuclear Information System (INIS)

    Watanabe, Tsukasa; Kon, Masahito; Nabeshima, Nobuo; Taniguchi, Kayoko

    2014-01-01

    Angular measurement technology at high resolution for applications such as in hard disk drive manufacturing machines, precision measurement equipment and aspherical process machines requires a rotary encoder with high accuracy, high resolution and high response speed. However, a rotary encoder has angular deviation factors during operation due to scale error or installation error. It has been assumed to be impossible to achieve accuracy below 0.1″ in angular measurement or control after the installation onto the rotating axis. Self-calibration (Lu and Trumper 2007 CIRP Ann. 56 499; Kim et al 2011 Proc. MacroScale; Probst 2008 Meas. Sci. Technol. 19 015101; Probst et al Meas. Sci. Technol. 9 1059; Tadashi and Makoto 1993 J. Robot. Mechatronics 5 448; Ralf et al 2006 Meas. Sci. Technol. 17 2811) and cross-calibration (Probst et al 1998 Meas. Sci. Technol. 9 1059; Just et al 2009 Precis. Eng. 33 530; Burnashev 2013 Quantum Electron. 43 130) technologies for a rotary encoder have been actively discussed on the basis of the principle of circular closure. This discussion prompted the development of rotary tables which achieve reliable and high accuracy angular verification. We apply these technologies for the development of a rotary encoder not only to meet the requirement of super-high accuracy but also to meet that of super-high resolution. This paper presents the development of an encoder with 2 21 = 2097 152 resolutions per rotation (360°), that is, corresponding to a 0.62″ signal period, achieved by the combination of a laser rotary encoder supplied by Magnescale Co., Ltd and a self-calibratable encoder (SelfA) supplied by The National Institute of Advanced Industrial Science and Technology (AIST). In addition, this paper introduces the development of a rotary encoder to guarantee ±0.03″ accuracy at any point of the interpolated signal, with respect to the encoder at the minimum resolution of 2 33 , that is, corresponding to a 0.0015″ signal period

  8. Ultra-high accuracy optical testing: creating diffraction-limitedshort-wavelength optical systems

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, Kenneth A.; Naulleau, Patrick P.; Rekawa, Senajith B.; Denham, Paul E.; Liddle, J. Alexander; Gullikson, Eric M.; Jackson, KeithH.; Anderson, Erik H.; Taylor, John S.; Sommargren, Gary E.; Chapman,Henry N.; Phillion, Donald W.; Johnson, Michael; Barty, Anton; Soufli,Regina; Spiller, Eberhard A.; Walton, Christopher C.; Bajt, Sasa

    2005-08-03

    Since 1993, research in the fabrication of extreme ultraviolet (EUV) optical imaging systems, conducted at Lawrence Berkeley National Laboratory (LBNL) and Lawrence Livermore National Laboratory (LLNL), has produced the highest resolution optical systems ever made. We have pioneered the development of ultra-high-accuracy optical testing and alignment methods, working at extreme ultraviolet wavelengths, and pushing wavefront-measuring interferometry into the 2-20-nm wavelength range (60-600 eV). These coherent measurement techniques, including lateral shearing interferometry and phase-shifting point-diffraction interferometry (PS/PDI) have achieved RMS wavefront measurement accuracies of 0.5-1-{angstrom} and better for primary aberration terms, enabling the creation of diffraction-limited EUV optics. The measurement accuracy is established using careful null-testing procedures, and has been verified repeatedly through high-resolution imaging. We believe these methods are broadly applicable to the advancement of short-wavelength optical systems including space telescopes, microscope objectives, projection lenses, synchrotron beamline optics, diffractive and holographic optics, and more. Measurements have been performed on a tunable undulator beamline at LBNL's Advanced Light Source (ALS), optimized for high coherent flux; although many of these techniques should be adaptable to alternative ultraviolet, EUV, and soft x-ray light sources. To date, we have measured nine prototype all-reflective EUV optical systems with NA values between 0.08 and 0.30 (f/6.25 to f/1.67). These projection-imaging lenses were created for the semiconductor industry's advanced research in EUV photolithography, a technology slated for introduction in 2009-13. This paper reviews the methods used and our program's accomplishments to date.

  9. Ultra-high accuracy optical testing: creating diffraction-limited short-wavelength optical systems

    International Nuclear Information System (INIS)

    Goldberg, Kenneth A.; Naulleau, Patrick P.; Rekawa, Senajith B.; Denham, Paul E.; Liddle, J. Alexander; Gullikson, Eric M.; Jackson, KeithH.; Anderson, Erik H.; Taylor, John S.; Sommargren, Gary E.; Chapman, Henry N.; Phillion, Donald W.; Johnson, Michael; Barty, Anton; Soufli, Regina; Spiller, Eberhard A.; Walton, Christopher C.; Bajt, Sasa

    2005-01-01

    Since 1993, research in the fabrication of extreme ultraviolet (EUV) optical imaging systems, conducted at Lawrence Berkeley National Laboratory (LBNL) and Lawrence Livermore National Laboratory (LLNL), has produced the highest resolution optical systems ever made. We have pioneered the development of ultra-high-accuracy optical testing and alignment methods, working at extreme ultraviolet wavelengths, and pushing wavefront-measuring interferometry into the 2-20-nm wavelength range (60-600 eV). These coherent measurement techniques, including lateral shearing interferometry and phase-shifting point-diffraction interferometry (PS/PDI) have achieved RMS wavefront measurement accuracies of 0.5-1-(angstrom) and better for primary aberration terms, enabling the creation of diffraction-limited EUV optics. The measurement accuracy is established using careful null-testing procedures, and has been verified repeatedly through high-resolution imaging. We believe these methods are broadly applicable to the advancement of short-wavelength optical systems including space telescopes, microscope objectives, projection lenses, synchrotron beamline optics, diffractive and holographic optics, and more. Measurements have been performed on a tunable undulator beamline at LBNL's Advanced Light Source (ALS), optimized for high coherent flux; although many of these techniques should be adaptable to alternative ultraviolet, EUV, and soft x-ray light sources. To date, we have measured nine prototype all-reflective EUV optical systems with NA values between 0.08 and 0.30 (f/6.25 to f/1.67). These projection-imaging lenses were created for the semiconductor industry's advanced research in EUV photolithography, a technology slated for introduction in 2009-13. This paper reviews the methods used and our program's accomplishments to date

  10. The use of high accuracy NAA for the certification of NIST botanical standard reference materials

    International Nuclear Information System (INIS)

    Becker, D.A.; Greenberg, R.R.; Stone, S.F.

    1992-01-01

    Neutron activation analysis is one of many analytical techniques used at the National Institute of Standards and Technology (NIST) for the certification of NIST Standard Reference Materials (SRMs). NAA competes favorably with all other techniques because of it's unique capabilities for high accuracy even at very low concentrations for many elements. In this paper, instrumental and radiochemical NAA results are described for 25 elements in two new NIST SRMs, SRM 1515 (Apple Leaves) and SRM 1547 (Peach Leaves), and are compared to the certified values for 19 elements in these two new botanical reference materials. (author) 7 refs.; 4 tabs

  11. High-accuracy critical exponents for O(N) hierarchical 3D sigma models

    International Nuclear Information System (INIS)

    Godina, J. J.; Li, L.; Meurice, Y.; Oktay, M. B.

    2006-01-01

    The critical exponent γ and its subleading exponent Δ in the 3D O(N) Dyson's hierarchical model for N up to 20 are calculated with high accuracy. We calculate the critical temperatures for the measure δ(φ-vector.φ-vector-1). We extract the first coefficients of the 1/N expansion from our numerical data. We show that the leading and subleading exponents agree with Polchinski equation and the equivalent Litim equation, in the local potential approximation, with at least 4 significant digits

  12. A variational nodal diffusion method of high accuracy; Varijaciona nodalna difuziona metoda visoke tachnosti

    Energy Technology Data Exchange (ETDEWEB)

    Tomasevic, Dj; Altiparmarkov, D [Institut za Nuklearne Nauke Boris Kidric, Belgrade (Yugoslavia)

    1988-07-01

    A variational nodal diffusion method with accurate treatment of transverse leakage shape is developed and presented in this paper. Using Legendre expansion in transverse coordinates higher order quasi-one-dimensional nodal equations are formulated. Numerical solution has been carried out using analytical solutions in alternating directions assuming Legendre expansion of the RHS term. The method has been tested against 2D and 3D IAEA benchmark problem, as well as 2D CANDU benchmark problem. The results are highly accurate. The first order approximation yields to the same order of accuracy as the standard nodal methods with quadratic leakage approximation, while the second order reaches reference solution. (author)

  13. A new ultra-high-accuracy angle generator: current status and future direction

    Science.gov (United States)

    Guertin, Christian F.; Geckeler, Ralf D.

    2017-09-01

    Lack of an extreme high-accuracy angular positioning device available in the United States has left a gap in industrial and scientific efforts conducted there, requiring certain user groups to undertake time-consuming work with overseas laboratories. Specifically, in x-ray mirror metrology the global research community is advancing the state-of-the-art to unprecedented levels. We aim to fill this U.S. gap by developing a versatile high-accuracy angle generator as a part of the national metrology tool set for x-ray mirror metrology and other important industries. Using an established calibration technique to measure the errors of the encoder scale graduations for full-rotation rotary encoders, we implemented an optimized arrangement of sensors positioned to minimize propagation of calibration errors. Our initial feasibility research shows that upon scaling to a full prototype and including additional calibration techniques we can expect to achieve uncertainties at the level of 0.01 arcsec (50 nrad) or better and offer the immense advantage of a highly automatable and customizable product to the commercial market.

  14. High Accuracy, Miniature Pressure Sensor for Very High Temperatures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — SiWave proposes to develop a compact, low-cost MEMS-based pressure sensor for very high temperatures and low pressures in hypersonic wind tunnels. Most currently...

  15. Electrospray Ionization Mass Spectrometric Analysis of Highly Reactive Glycosyl Halides

    Directory of Open Access Journals (Sweden)

    Lajos Kovács

    2012-07-01

    Full Text Available Highly reactive glycosyl chlorides and bromides have been analysed by a routine mass spectrometric method using electrospray ionization and lithium salt adduct-forming agents in anhydrous acetonitrile solution, providing salient lithiated molecular ions [M+Li]+, [2M+Li]+ etc. The role of other adduct-forming salts has also been evaluated. The lithium salt method is useful for accurate mass determination of these highly sensitive compounds.

  16. A Massive Prestellar Clump Hosting No High-mass Cores

    Energy Technology Data Exchange (ETDEWEB)

    Sanhueza, Patricio; Lu, Xing; Tatematsu, Ken’ichi [National Astronomical Observatory of Japan, National Institutes of Natural Sciences, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Jackson, James M. [School of Mathematical and Physical Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308 (Australia); Zhang, Qizhou; Stephens, Ian W. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Guzmán, Andrés E. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Wang, Ke, E-mail: patricio.sanhueza@nao.ac.jp [European Southern Observatory (ESO) Headquarters, Karl-Schwarzschild-Str. 2, D-85748 Garching bei München (Germany)

    2017-06-01

    The infrared dark cloud (IRDC) G028.23-00.19 hosts a massive (1500 M {sub ⊙}), cold (12 K), and 3.6–70 μ m IR dark clump (MM1) that has the potential to form high-mass stars. We observed this prestellar clump candidate with the Submillimeter Array (∼3.″5 resolution) and Jansky Very Large Array (∼2.″1 resolution) in order to characterize the early stages of high-mass star formation and to constrain theoretical models. Dust emission at 1.3 mm wavelength reveals five cores with masses ≤15 M {sub ⊙}. None of the cores currently have the mass reservoir to form a high-mass star in the prestellar phase. If the MM1 clump will ultimately form high-mass stars, its embedded cores must gather a significant amount of additional mass over time. No molecular outflows are detected in the CO (2-1) and SiO (5-4) transitions, suggesting that the SMA cores are starless. By using the NH{sub 3} (1, 1) line, the velocity dispersion of the gas is determined to be transonic or mildly supersonic (Δ V {sub nt}/Δ V {sub th} ∼ 1.1–1.8). The cores are not highly supersonic as some theories of high-mass star formation predict. The embedded cores are four to seven times more massive than the clump thermal Jeans mass and the most massive core (SMA1) is nine times less massive than the clump turbulent Jeans mass. These values indicate that neither thermal pressure nor turbulent pressure dominates the fragmentation of MM1. The low virial parameters of the cores (0.1–0.5) suggest that they are not in virial equilibrium, unless strong magnetic fields of ∼1–2 mG are present. We discuss high-mass star formation scenarios in a context based on IRDC G028.23-00.19, a study case believed to represent the initial fragmentation of molecular clouds that will form high-mass stars.

  17. Perfusion pattern and time of vascularisation with CEUS increase accuracy in differentiating between benign and malignant tumours in 216 musculoskeletal soft tissue masses

    Energy Technology Data Exchange (ETDEWEB)

    De Marchi, Armanda, E-mail: armanda.demarchi@tiscali.it [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Prever, Elena Brach del, E-mail: elena.brach@unito.it [Department of OrthopaedicOncology and ReconstructiveSurgery, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Cavallo, Franco, E-mail: franco.cavallo@unito.it [Department of Public health and Paediatrics, University of Turin, Via Santena 5-bis, 10126 Torino (Italy); Pozza, Simona, E-mail: simona.pozza@tin.it [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Linari, Alessandra, E-mail: linaralessandra@libero.it [Department of Pathology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Regina Margherita Hospital, Piazza Polonia, 10126 Torino (Italy); Lombardo, Paolo, E-mail: pao.lombardo82@gmail.com [Department of DiagnosticImaging and Radiotherapy of the University of Turin, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Via Genova 3, 10126 Torino (Italy); Comandone, Alessandro, E-mail: alessandro.comandone@gradenigo.it [Department of Oncology, Gradenigo Hospital, Corso Regina Margherita, 8/10.10153 Torino (Italy); Piana, Raimondo, E-mail: raimondo.piana@libero.it [Department of OrthopaedicOncology and ReconstructiveSurgery, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Faletti, Carlo [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy)

    2015-01-15

    Introduction: Musculoskeletal Soft Tissue Tumours (STT) are frequent heterogeneous lesions. Guidelines consider a mass larger than 5 cm and deep with respect to the deep fascia potentially malignant. Contrast Enhanced Ultrasound (CEUS) can detect both vascularity and tumour neoangiogenesis. We hypothesised that perfusion patterns and vascularisation time could improve the accuracy of CEUS in discriminating malignant tumours from benign lesions. Materials and methods: 216 STT were studied: 40% benign lesions, 60% malignant tumours, 56% in the lower limbs. Seven CEUS perfusion patterns and three types of vascularisation (arterial-venous uptake, absence of uptake) were applied. Accuracy was evaluated by comparing imaging with the histological diagnosis. Univariate and multivariate analysis, Chi-square test and t-test for independent variables were applied; significance was set at p < 0.05 level, 95% computed CI. Results: CEUS pattern 6 (inhomogeneous perfusion), arterial uptake and location in the lower limb were associated with high risk of malignancy. CEUS pattern has PPV 77%, rapidity of vascularisation PPV 69%; location in the limbs is the most sensitive indicator, but NPV 52%, PPV 65%. The combination of CEUS-pattern and vascularisation has 74% PPV, 60% NPV, 70% sensitivity. No correlation with size and location in relation to the deep fascia was found. Conclusion: US with CEUS qualitative analysis could be an accurate technique to identify potentially malignant STT, for which second line imaging and biopsy are indicated in Referral Centers. Intense inhomogeneous enhancement with avascular areas and rapid vascularisation time could be useful in discriminating benign from malignant SST, overall when the lower limbs are involved.

  18. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis.

    Science.gov (United States)

    Spraggins, Jeffrey M; Rizzo, David G; Moore, Jessica L; Noto, Michael J; Skaar, Eric P; Caprioli, Richard M

    2016-06-01

    MALDI imaging mass spectrometry is a powerful analytical tool enabling the visualization of biomolecules in tissue. However, there are unique challenges associated with protein imaging experiments including the need for higher spatial resolution capabilities, improved image acquisition rates, and better molecular specificity. Here we demonstrate the capabilities of ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR IMS platforms as they relate to these challenges. High spatial resolution MALDI-TOF protein images of rat brain tissue and cystic fibrosis lung tissue were acquired at image acquisition rates >25 pixels/s. Structures as small as 50 μm were spatially resolved and proteins associated with host immune response were observed in cystic fibrosis lung tissue. Ultra-high speed MALDI-TOF enables unique applications including megapixel molecular imaging as demonstrated for lipid analysis of cystic fibrosis lung tissue. Additionally, imaging experiments using MALDI FTICR IMS were shown to produce data with high mass accuracy (z 5000) for proteins up to ∼20 kDa. Analysis of clear cell renal cell carcinoma using MALDI FTICR IMS identified specific proteins localized to healthy tissue regions, within the tumor, and also in areas of increased vascularization around the tumor. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis.

    Science.gov (United States)

    Markiewicz, Pawel J; Ehrhardt, Matthias J; Erlandsson, Kjell; Noonan, Philip J; Barnes, Anna; Schott, Jonathan M; Atkinson, David; Arridge, Simon R; Hutton, Brian F; Ourselin, Sebastien

    2018-01-01

    We present a standalone, scalable and high-throughput software platform for PET image reconstruction and analysis. We focus on high fidelity modelling of the acquisition processes to provide high accuracy and precision quantitative imaging, especially for large axial field of view scanners. All the core routines are implemented using parallel computing available from within the Python package NiftyPET, enabling easy access, manipulation and visualisation of data at any processing stage. The pipeline of the platform starts from MR and raw PET input data and is divided into the following processing stages: (1) list-mode data processing; (2) accurate attenuation coefficient map generation; (3) detector normalisation; (4) exact forward and back projection between sinogram and image space; (5) estimation of reduced-variance random events; (6) high accuracy fully 3D estimation of scatter events; (7) voxel-based partial volume correction; (8) region- and voxel-level image analysis. We demonstrate the advantages of this platform using an amyloid brain scan where all the processing is executed from a single and uniform computational environment in Python. The high accuracy acquisition modelling is achieved through span-1 (no axial compression) ray tracing for true, random and scatter events. Furthermore, the platform offers uncertainty estimation of any image derived statistic to facilitate robust tracking of subtle physiological changes in longitudinal studies. The platform also supports the development of new reconstruction and analysis algorithms through restricting the axial field of view to any set of rings covering a region of interest and thus performing fully 3D reconstruction and corrections using real data significantly faster. All the software is available as open source with the accompanying wiki-page and test data.

  20. A generalized polynomial chaos based ensemble Kalman filter with high accuracy

    International Nuclear Information System (INIS)

    Li Jia; Xiu Dongbin

    2009-01-01

    As one of the most adopted sequential data assimilation methods in many areas, especially those involving complex nonlinear dynamics, the ensemble Kalman filter (EnKF) has been under extensive investigation regarding its properties and efficiency. Compared to other variants of the Kalman filter (KF), EnKF is straightforward to implement, as it employs random ensembles to represent solution states. This, however, introduces sampling errors that affect the accuracy of EnKF in a negative manner. Though sampling errors can be easily reduced by using a large number of samples, in practice this is undesirable as each ensemble member is a solution of the system of state equations and can be time consuming to compute for large-scale problems. In this paper we present an efficient EnKF implementation via generalized polynomial chaos (gPC) expansion. The key ingredients of the proposed approach involve (1) solving the system of stochastic state equations via the gPC methodology to gain efficiency; and (2) sampling the gPC approximation of the stochastic solution with an arbitrarily large number of samples, at virtually no additional computational cost, to drastically reduce the sampling errors. The resulting algorithm thus achieves a high accuracy at reduced computational cost, compared to the classical implementations of EnKF. Numerical examples are provided to verify the convergence property and accuracy improvement of the new algorithm. We also prove that for linear systems with Gaussian noise, the first-order gPC Kalman filter method is equivalent to the exact Kalman filter.

  1. A high accuracy algorithm of displacement measurement for a micro-positioning stage

    Directory of Open Access Journals (Sweden)

    Xiang Zhang

    2017-05-01

    Full Text Available A high accuracy displacement measurement algorithm for a two degrees of freedom compliant precision micro-positioning stage is proposed based on the computer micro-vision technique. The algorithm consists of an integer-pixel and a subpixel matching procedure. Series of simulations are conducted to verify the proposed method. The results show that the proposed algorithm possesses the advantages of high precision and stability, the resolution can attain to 0.01 pixel theoretically. In addition, the consuming time is reduced about 6.7 times compared with the classical normalized cross correlation algorithm. To validate the practical performance of the proposed algorithm, a laser interferometer measurement system (LIMS is built up. The experimental results demonstrate that the algorithm has better adaptability than that of the LIMS.

  2. Prediction of novel pre-microRNAs with high accuracy through boosting and SVM.

    Science.gov (United States)

    Zhang, Yuanwei; Yang, Yifan; Zhang, Huan; Jiang, Xiaohua; Xu, Bo; Xue, Yu; Cao, Yunxia; Zhai, Qian; Zhai, Yong; Xu, Mingqing; Cooke, Howard J; Shi, Qinghua

    2011-05-15

    High-throughput deep-sequencing technology has generated an unprecedented number of expressed short sequence reads, presenting not only an opportunity but also a challenge for prediction of novel microRNAs. To verify the existence of candidate microRNAs, we have to show that these short sequences can be processed from candidate pre-microRNAs. However, it is laborious and time consuming to verify these using existing experimental techniques. Therefore, here, we describe a new method, miRD, which is constructed using two feature selection strategies based on support vector machines (SVMs) and boosting method. It is a high-efficiency tool for novel pre-microRNA prediction with accuracy up to 94.0% among different species. miRD is implemented in PHP/PERL+MySQL+R and can be freely accessed at http://mcg.ustc.edu.cn/rpg/mird/mird.php.

  3. Computer modeling of oil spill trajectories with a high accuracy method

    International Nuclear Information System (INIS)

    Garcia-Martinez, Reinaldo; Flores-Tovar, Henry

    1999-01-01

    This paper proposes a high accuracy numerical method to model oil spill trajectories using a particle-tracking algorithm. The Euler method, used to calculate oil trajectories, can give adequate solutions in most open ocean applications. However, this method may not predict accurate particle trajectories in certain highly non-uniform velocity fields near coastal zones or in river problems. Simple numerical experiments show that the Euler method may also introduce artificial numerical dispersion that could lead to overestimation of spill areas. This article proposes a fourth-order Runge-Kutta method with fourth-order velocity interpolation to calculate oil trajectories that minimise these problems. The algorithm is implemented in the OilTrack model to predict oil trajectories following the 'Nissos Amorgos' oil spill accident that occurred in the Gulf of Venezuela in 1997. Despite lack of adequate field information, model results compare well with observations in the impacted area. (Author)

  4. High-precision predictions for the light CP-even Higgs boson mass of the MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, T.; Hollik, W. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Heinemeyer, S. [Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Rzehak, H. [Freiburg Univ. (Germany). Physikalisches Inst.; Weiglein, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2014-03-15

    For the interpretation of the signal discovered in the Higgs searches at the LHC it will be crucial in particular to discriminate between the minimal Higgs sector realised in the Standard Model (SM) and its most commonly studied extension, the Minimal Supersymmetric SM (MSSM). The measured mass value, having already reached the level of a precision observable with an experimental accuracy of about 500 MeV, plays an important role in this context. In the MSSM the mass of the light CP-even Higgs boson, M{sub h}, can directly be predicted from the other parameters of the model. The accuracy of this prediction should at least match the one of the experimental result. The relatively high mass value of about 126 GeV has led to many investigations where the scalar top quarks are in the multi-TeV range. We improve the prediction for M{sub h} in the MSSM by combining the existing fixed-order result, comprising the full one-loop and leading and subleading two-loop corrections, with a resummation of the leading and subleading logarithmic contributions from the scalar top sector to all orders. In this way for the first time a high-precision prediction for the mass of the light CP-even Higgs boson in the MSSM is possible all the way up to the multi-TeV region of the relevant supersymmetric particles. The results are included in the code FeynHiggs.

  5. An Automated High Performance Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for High-Throughput Proteomics

    International Nuclear Information System (INIS)

    Belov, Mikhail E.; Anderson, Gordon A.; Wingerd, Mark A.; Udseth, Harold R.; Tang, Keqi; Prior, David C.; Swanson, Kenneth R.; Buschbach, Michael A.; Strittmatter, Eric F.; Moore, Ronald J.; Smith, Richard D.

    2004-01-01

    We report on a fully automated 9.4 tesla Fourier transform ion resonance cyclotron (FTICR) mass spectrometer coupled to reverse-phase chromatography for high-throughput proteomic studies. Modifications made to the front-end of a commercial FTICR instrument--a dual-ESI-emitter ion source; dual-channel electrodynamic ion funnel; and collisional-cooling, selection and accumulation quadrupoles--significantly improved the sensitivity, dynamic range and mass measurement accuracy of the mass spectrometer. A high-pressure capillary liquid chromatography (LC) system was incorporated with an autosampler that enabled 24 h/day operation. A novel method for accumulating ions in the ICR cell was also developed. Unattended operation of the instrument revealed the exceptional reproducibility (1-5% deviation in elution times for peptides from a bacterial proteome), repeatability (10-20% deviation in detected abundances for peptides from the same aliquot analyzed a few weeks apart) and robustness (high-throughput operation for 5 months without downtime) of the LC/FTICR system. When combined with modulated-ion-energy gated trapping, the internal calibration of FTICR mass spectra decreased dispersion of mass measurement errors for peptide identifications in conjunction with high resolution capillary LC separations to < 5 ppm over a dynamic range for each spectrum of 10 3

  6. Treatment accuracy of hypofractionated spine and other highly conformal IMRT treatments

    International Nuclear Information System (INIS)

    Sutherland, B.; Hanlon, P.; Charles, P.

    2011-01-01

    Full text: Spinal cord metastases pose difficult challenges for radiation treatment due to tight dose constraints and a concave PTY. This project aimed to thoroughly test the treatment accuracy of the Eclipse Treatment Planning System (TPS) for highly modulated IMRT treatments, in particular of the thoracic spine, using an Elekta Synergy Linear Accelerator. The increased understanding obtained through different quality assurance techniques allowed recommendations to be made for treatment site commissioning with improved accuracy at the Princess Alexandra Hospital (PAH). Three thoracic spine IMRT plans at the PAH were used for data collection. Complex phantom models were built using CT data, and fields simulated using Monte Carlo modelling. The simulated dose distributions were compared with the TPS using gamma analysis and DYH comparison. High resolution QA was done for all fields using the MatriXX ion chamber array, MapCHECK2 diode array shifted, and the EPlD to determine a procedure for commissioning new treatment sites. Basic spine simulations found the TPS overestimated absorbed dose to bone, however within spinal cord there was good agreement. High resolution QA found the average gamma pass rate of the fields to be 99.1 % for MatriXX, 96.5% for MapCHECK2 shifted and 97.7% for EPlD. Preliminary results indicate agreement between the TPS and delivered dose distributions higher than previously believed for the investigated IMRT plans. The poor resolution of the MatriXX, and normalisation issues with MapCHECK2 leads to probable recommendation of EPlD for future IMRT commissioning due to the high resolution and minimal setup required.

  7. High efficiency nebulization for helium inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    Jorabchi, Kaveh; McCormick, Ryan; Levine, Jonathan A.; Liu Huiying; Nam, S.-H.; Montaser, Akbar

    2006-01-01

    A pneumatically-driven, high efficiency nebulizer is explored for helium inductively coupled plasma mass spectrometry. The aerosol characteristics and analyte transport efficiencies of the high efficiency nebulizer for nebulization with helium are measured and compared to the results obtained with argon. Analytical performance indices of the helium inductively coupled plasma mass spectrometry are evaluated in terms of detection limits and precision. The helium inductively coupled plasma mass spectrometry detection limits obtained with the high efficiency nebulizer at 200 μL/min are higher than those achieved with the ultrasonic nebulizer consuming 2 mL/min solution, however, precision is generally better with high efficiency nebulizer (1-4% vs. 3-8% with ultrasonic nebulizer). Detection limits with the high efficiency nebulizer at 200 μL/min solution uptake rate approach those using ultrasonic nebulizer upon efficient desolvation with a heated spray chamber followed by a Peltier-cooled multipass condenser

  8. Mass terms in effective theories of high density quark matter

    Science.gov (United States)

    Schäfer, T.

    2002-04-01

    We study the structure of mass terms in the effective theory for quasiparticles in QCD at high baryon density. To next-to-leading order in the 1/pF expansion we find two types of mass terms: chirality conserving two-fermion operators and chirality violating four-fermion operators. In the effective chiral theory for Goldstone modes in the color-flavor-locked (CFL) phase the former terms correspond to effective chemical potentials, while the latter lead to Lorentz invariant mass terms. We compute the masses of Goldstone bosons in the CFL phase, confirming earlier results by Son and Stephanov as well as Bedaque and Schäfer. We show that to leading order in the coupling constant g there is no antiparticle gap contribution to the mass of Goldstone modes, and that our results are independent of the choice of gauge.

  9. High Accuracy, High Energy He-Erd Analysis of H,C, and T

    International Nuclear Information System (INIS)

    Browning, James F.; Langley, Robert A.; Doyle, Barney L.; Banks, James C.; Wampler, William R.

    1999-01-01

    A new analysis technique using high-energy helium ions for the simultaneous elastic recoil detection of all three hydrogen isotopes in metal hydride systems extending to depths of several microm's is presented. Analysis shows that it is possible to separate each hydrogen isotope in a heavy matrix such as erbium to depths of 5 microm using incident 11.48MeV 4 He 2 ions with a detection system composed of a range foil and ΔE-E telescope detector. Newly measured cross sections for the elastic recoil scattering of 4 He 2 ions from protons and deuterons are presented in the energy range 10 to 11.75 MeV for the laboratory recoil angle of 30degree

  10. PACMAN Project: A New Solution for the High-accuracy Alignment of Accelerator Components

    CERN Document Server

    Mainaud Durand, Helene; Buzio, Marco; Caiazza, Domenico; Catalán Lasheras, Nuria; Cherif, Ahmed; Doytchinov, Iordan; Fuchs, Jean-Frederic; Gaddi, Andrea; Galindo Munoz, Natalia; Gayde, Jean-Christophe; Kamugasa, Solomon; Modena, Michele; Novotny, Peter; Russenschuck, Stephan; Sanz, Claude; Severino, Giordana; Tshilumba, David; Vlachakis, Vasileios; Wendt, Manfred; Zorzetti, Silvia

    2016-01-01

    The beam alignment requirements for the next generation of lepton colliders have become increasingly challenging. As an example, the alignment requirements for the three major collider components of the CLIC linear collider are as follows. Before the first beam circulates, the Beam Position Monitors (BPM), Accelerating Structures (AS)and quadrupoles will have to be aligned up to 10 μm w.r.t. a straight line over 200 m long segments, along the 20 km of linacs. PACMAN is a study on Particle Accelerator Components' Metrology and Alignment to the Nanometre scale. It is an Innovative Doctoral Program, funded by the EU and hosted by CERN, providing high quality training to 10 Early Stage Researchers working towards a PhD thesis. The technical aim of the project is to improve the alignment accuracy of the CLIC components by developing new methods and tools addressing several steps of alignment simultaneously, to gain time and accuracy. The tools and methods developed will be validated on a test bench. This paper pr...

  11. Accuracy assessment of NOAA gridded daily reference evapotranspiration for the Texas High Plains

    Science.gov (United States)

    Moorhead, Jerry; Gowda, Prasanna H.; Hobbins, Michael; Senay, Gabriel; Paul, George; Marek, Thomas; Porter, Dana

    2015-01-01

    The National Oceanic and Atmospheric Administration (NOAA) provides daily reference evapotranspiration (ETref) maps for the contiguous United States using climatic data from North American Land Data Assimilation System (NLDAS). This data provides large-scale spatial representation of ETref, which is essential for regional scale water resources management. Data used in the development of NOAA daily ETref maps are derived from observations over surfaces that are different from short (grass — ETos) or tall (alfalfa — ETrs) reference crops, often in nonagricultural settings, which carries an unknown discrepancy between assumed and actual conditions. In this study, NOAA daily ETos and ETrs maps were evaluated for accuracy, using observed data from the Texas High Plains Evapotranspiration (TXHPET) network. Daily ETos, ETrs and the climatic data (air temperature, wind speed, and solar radiation) used for calculating ETref were extracted from the NOAA maps for TXHPET locations and compared against ground measurements on reference grass surfaces. NOAA ETrefmaps generally overestimated the TXHPET observations (1.4 and 2.2 mm/day ETos and ETrs, respectively), which may be attributed to errors in the NLDAS modeled air temperature and wind speed, to which reference ETref is most sensitive. Therefore, a bias correction to NLDAS modeled air temperature and wind speed data, or adjustment to the resulting NOAA ETref, may be needed to improve the accuracy of NOAA ETref maps.

  12. High Accuracy Beam Current Monitor System for CEBAF'S Experimental Hall A

    International Nuclear Information System (INIS)

    J. Denard; A. Saha; G. Lavessiere

    2001-01-01

    CEBAF accelerator delivers continuous wave (CW) electron beams to three experimental Halls. In Hall A, all experiments require continuous, non-invasive current measurements and a few experiments require an absolute accuracy of 0.2 % in the current range from 1 to 180 (micro)A. A Parametric Current Transformer (PCT), manufactured by Bergoz, has an accurate and stable sensitivity of 4 (micro)A/V but its offset drifts at the muA level over time preclude its direct use for continuous measurements. Two cavity monitors are calibrated against the PCT with at least 50 (micro)A of beam current. The calibration procedure suppresses the error due to PCT's offset drifts by turning the beam on and off, which is invasive to the experiment. One of the goals of the system is to minimize the calibration time without compromising the measurement's accuracy. The linearity of the cavity monitors is a critical parameter for transferring the accurate calibration done at high currents over the whole dynamic range. The method for measuring accurately the linearity is described

  13. Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants.

    Science.gov (United States)

    Eisenberger, Ute; Wüthrich, Rudolf P; Bock, Andreas; Ambühl, Patrice; Steiger, Jürg; Intondi, Allison; Kuranoff, Susan; Maier, Thomas; Green, Damian; DiCarlo, Lorenzo; Feutren, Gilles; De Geest, Sabina

    2013-08-15

    This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence. ISS consists of an ingestible event marker (IEM), a microsensor that becomes activated in gastric fluid, and an adhesive personal monitor (APM) that detects IEM activation. In this study, the IEM was combined to enteric-coated mycophenolate sodium (ECMPS). Twenty stable adult kidney transplants received IEM-ECMPS for a mean of 9.2 weeks totaling 1227 cumulative days. Eight patients prematurely discontinued treatment due to ECMPS gastrointestinal symptoms (n=2), skin intolerance to APM (n=2), and insufficient system usability (n=4). Rash or erythema due to APM was reported in 7 (37%) patients, all during the first month of use. No serious or severe adverse events and no rejection episode were reported. IEM detection accuracy was 100% over 34 directly observed ingestions; Taking Adherence was 99.4% over a total of 2824 prescribed IEM-ECMPS ingestions. ISS could detect accurately the ingestion of two IEM-ECMPS capsules taken at the same time (detection rate of 99.3%, n=2376). ISS is a promising new technology that provides highly reliable measurements of intake and timing of intake of drugs that are combined with the IEM.

  14. Combined Scintigraphy and Tumor Marker Analysis Predicts Unfavorable Histopathology of Neuroblastic Tumors with High Accuracy.

    Directory of Open Access Journals (Sweden)

    Wolfgang Peter Fendler

    Full Text Available Our aim was to improve the prediction of unfavorable histopathology (UH in neuroblastic tumors through combined imaging and biochemical parameters.123I-MIBG SPECT and MRI was performed before surgical resection or biopsy in 47 consecutive pediatric patients with neuroblastic tumor. Semi-quantitative tumor-to-liver count-rate ratio (TLCRR, MRI tumor size and margins, urine catecholamine and NSE blood levels of neuron specific enolase (NSE were recorded. Accuracy of single and combined variables for prediction of UH was tested by ROC analysis with Bonferroni correction.34 of 47 patients had UH based on the International Neuroblastoma Pathology Classification (INPC. TLCRR and serum NSE both predicted UH with moderate accuracy. Optimal cut-off for TLCRR was 2.0, resulting in 68% sensitivity and 100% specificity (AUC-ROC 0.86, p < 0.001. Optimal cut-off for NSE was 25.8 ng/ml, resulting in 74% sensitivity and 85% specificity (AUC-ROC 0.81, p = 0.001. Combination of TLCRR/NSE criteria reduced false negative findings from 11/9 to only five, with improved sensitivity and specificity of 85% (AUC-ROC 0.85, p < 0.001.Strong 123I-MIBG uptake and high serum level of NSE were each predictive of UH. Combined analysis of both parameters improved the prediction of UH in patients with neuroblastic tumor. MRI parameters and urine catecholamine levels did not predict UH.

  15. Enhancing the Accuracy of Advanced High Temperature Mechanical Testing through Thermography

    Directory of Open Access Journals (Sweden)

    Jonathan Jones

    2018-03-01

    Full Text Available This paper describes the advantages and enhanced accuracy thermography provides to high temperature mechanical testing. This technique is not only used to monitor, but also to control test specimen temperatures where the infra-red technique enables accurate non-invasive control of rapid thermal cycling for non-metallic materials. Isothermal and dynamic waveforms are employed over a 200–800 °C temperature range to pre-oxidised and coated specimens to assess the capability of the technique. This application shows thermography to be accurate to within ±2 °C of thermocouples, a standardised measurement technique. This work demonstrates the superior visibility of test temperatures previously unobtainable by conventional thermocouples or even more modern pyrometers that thermography can deliver. As a result, the speed and accuracy of thermal profiling, thermal gradient measurements and cold/hot spot identification using the technique has increased significantly to the point where temperature can now be controlled by averaging over a specified area. The increased visibility of specimen temperatures has revealed additional unknown effects such as thermocouple shadowing, preferential crack tip heating within an induction coil, and, fundamental response time of individual measurement techniques which are investigated further.

  16. An output amplitude configurable wideband automatic gain control with high gain step accuracy

    International Nuclear Information System (INIS)

    He Xiaofeng; Ye Tianchun; Mo Taishan; Ma Chengyan

    2012-01-01

    An output amplitude configurable wideband automatic gain control (AGC) with high gain step accuracy for the GNSS receiver is presented. The amplitude of an AGC is configurable in order to cooperate with baseband chips to achieve interference suppression and be compatible with different full range ADCs. And what's more, the gain-boosting technology is introduced and the circuit is improved to increase the step accuracy. A zero, which is composed by the source feedback resistance and the source capacity, is introduced to compensate for the pole. The AGC is fabricated in a 0.18 μm CMOS process. The AGC shows a 62 dB gain control range by 1 dB each step with a gain error of less than 0.2 dB. The AGC provides 3 dB bandwidth larger than 80 MHz and the overall power consumption is less than 1.8 mA, and the die area is 800 × 300 μm 2 . (semiconductor integrated circuits)

  17. High accuracy of family history of melanoma in Danish melanoma cases.

    Science.gov (United States)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-12-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma probands who reported 199 cases of melanoma in relatives, of which 135 cases where in first degree relatives. We confirmed the diagnosis of melanoma in 77% of all relatives, and in 83% of first degree relatives. In 181 probands we validated the negative family history of melanoma in 748 first degree relatives and found only 1 case of melanoma which was not reported in a 3 case melanoma family. Melanoma patients in Denmark report family history of melanoma in first and second degree relatives with a high level of accuracy with a true positive predictive value between 77 and 87%. In 99% of probands reporting a negative family history of melanoma in first degree relatives this information is correct. In clinical practice we recommend that melanoma diagnosis in relatives should be verified if possible, but even unverified reported melanoma cases in relatives should be included in the indication of genetic testing and assessment of melanoma risk in the family.

  18. Accuracy of Percutaneous Core Biopsy in the Diagnosis of Small Renal Masses (≤4.0 cm: A Meta-analysis

    Directory of Open Access Journals (Sweden)

    Qiqi He

    2015-02-01

    Full Text Available Objective To use meta-analysis to determine the accuracy of percutaneous core needle biopsy in the diagnosis of small renal masses (SMRs≤4.0 cm. Materials and Methods Studies were identified by searching PubMed, Embase, and the Cochrane Library database up to March 2013. Two of the authors independently assessed the study quality using QUADAS-2 tool and extracted data that met the inclusion criteria. The sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR and also summary receiver operating characteristic (SROC curve were investigated and draw. Deek’s funnel plot was used to evaluate the publication bias. Result A total of 9 studies with 788 patients (803 biopsies were included. Failed biopsies without repeated or aborted from follow-up/surgery result were excluded (232 patients and 353 biopsies. For all cases, the pooled sensitivity was 94.0% (95% CI: 91.0%, 95.0%, the pooled positive likelihood was 22.57 (95% CI: 9.20-55.34, the pooled negative likelihood was 0.09 (95% CI: 0.06-0.13, the pooled DOR was 296.52(95% CI: 99. 42-884.38. The area under the curve of SROC analysis was 0.959±0.0254. Conclusion Imaging-guided percutaneous core needle biopsy of small renal masses (SMRs≤4.0 cm is highly accurate to malignant tumor diagnosis with unknown metastatic status and could be offered to some patients after clinic judgment prior to surgical intervention consideration.

  19. High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors

    DEFF Research Database (Denmark)

    Andersen, Thomas; Jensen, Robert; Christensen, M. K.

    2012-01-01

    We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal...

  20. Search for high mass resonances in dielectron final state

    CERN Document Server

    CMS Collaboration

    2018-01-01

    A search for high mass resonances in the dielectron final state is performed using proton-proton collision data at a center-of-mass energy of $13~\\mathrm{TeV}$ collected by the CMS experiment at the LHC in 2017. The integrated luminosity corresponds to $41~\\mathrm{fb}^{-1}$. No evidence for a significant deviation from standard model expectation is observed. The sensitivity of the search is increased by combining these data with a previously analysed set of data obtained in 2016 and corresponding to a luminosity of $36~\\mathrm{fb}^{-1}$. Upper bounds are set on the masses of hypothetical particles that arise in new-physics scenarios.

  1. High-throughput analysis of amino acids in plant materials by single quadrupole mass spectrometry

    DEFF Research Database (Denmark)

    Dahl-Lassen, Rasmus; van Hecke, Jan Julien Josef; Jørgensen, Henning

    2018-01-01

    that it is very time consuming with typical chromatographic run times of 70 min or more. Results: We have here developed a high-throughput method for analysis of amino acid profiles in plant materials. The method combines classical protein hydrolysis and derivatization with fast separation by UHPLC and detection...... reducing the overall analytical costs compared to methods based on more advanced mass spectrometers....... by a single quadrupole (QDa) mass spectrometer. The chromatographic run time is reduced to 10 min and the precision, accuracy and sensitivity of the method are in line with other recent methods utilizing advanced and more expensive mass spectrometers. The sensitivity of the method is at least a factor 10...

  2. Implications of the absence of high-mass radion signals

    Science.gov (United States)

    Ahmed, Aqeel; Dillon, Barry M.; Grzadkowski, Bohdan; Gunion, John F.; Jiang, Yun

    2017-05-01

    Given the disappearance of the 750 GeV diphoton LHC signal and the absence of signals at high mass in this and other channels, significant constraints on the mixed Higgs-radion of the five-dimensional Randall-Sundrum model arise. By combining all channels, these constraints place a significant radion-mass-dependent lower bound on the radion vacuum expectation value that is fairly independent of the amount of Higgs radion mixing.

  3. High Resolution Mass Spectrometry of Polyfluorinated Polyether-Based Formulation

    DEFF Research Database (Denmark)

    Dimzon, Ian Ken; Trier, Xenia; Frömel, Tobias

    2016-01-01

    High resolution mass spectrometry (HRMS) was successfully applied to elucidate the structure of a polyfluorinated polyether (PFPE)-based formulation. The mass spectrum generated from direct injection into the MS was examined by identifying the different repeating units manually and with the aid o......-fluorinated polymers. The information from MS is essential in studying the physico-chemical properties of PFPEs and can help in assessing the risks they pose to the environment and to human health. Graphical Abstract ᅟ....

  4. Validation of the Mass-Extraction-Window for Quantitative Methods Using Liquid Chromatography High Resolution Mass Spectrometry.

    Science.gov (United States)

    Glauser, Gaétan; Grund, Baptiste; Gassner, Anne-Laure; Menin, Laure; Henry, Hugues; Bromirski, Maciej; Schütz, Frédéric; McMullen, Justin; Rochat, Bertrand

    2016-03-15

    A paradigm shift is underway in the field of quantitative liquid chromatography-mass spectrometry (LC-MS) analysis thanks to the arrival of recent high-resolution mass spectrometers (HRMS). The capability of HRMS to perform sensitive and reliable quantifications of a large variety of analytes in HR-full scan mode is showing that it is now realistic to perform quantitative and qualitative analysis with the same instrument. Moreover, HR-full scan acquisition offers a global view of sample extracts and allows retrospective investigations as virtually all ionized compounds are detected with a high sensitivity. In time, the versatility of HRMS together with the increasing need for relative quantification of hundreds of endogenous metabolites should promote a shift from triple-quadrupole MS to HRMS. However, a current "pitfall" in quantitative LC-HRMS analysis is the lack of HRMS-specific guidance for validated quantitative analyses. Indeed, false positive and false negative HRMS detections are rare, albeit possible, if inadequate parameters are used. Here, we investigated two key parameters for the validation of LC-HRMS quantitative analyses: the mass accuracy (MA) and the mass-extraction-window (MEW) that is used to construct the extracted-ion-chromatograms. We propose MA-parameters, graphs, and equations to calculate rational MEW width for the validation of quantitative LC-HRMS methods. MA measurements were performed on four different LC-HRMS platforms. Experimentally determined MEW values ranged between 5.6 and 16.5 ppm and depended on the HRMS platform, its working environment, the calibration procedure, and the analyte considered. The proposed procedure provides a fit-for-purpose MEW determination and prevents false detections.

  5. Accuracy optimization of high-speed AFM measurements using Design of Experiments

    DEFF Research Database (Denmark)

    Tosello, Guido; Marinello, F.; Hansen, Hans Nørgaard

    2010-01-01

    Atomic Force Microscopy (AFM) is being increasingly employed in industrial micro/nano manufacturing applications and integrated into production lines. In order to achieve reliable process and product control at high measuring speed, instrument optimization is needed. Quantitative AFM measurement...... results are influenced by a number of scan settings parameters, defining topography sampling and measurement time: resolution (number of profiles and points per profile), scan range and direction, scanning force and speed. Such parameters are influencing lateral and vertical accuracy and, eventually......, the estimated dimensions of measured features. The definition of scan settings is based on a comprehensive optimization that targets maximization of information from collected data and minimization of measurement uncertainty and scan time. The Design of Experiments (DOE) technique is proposed and applied...

  6. Recent high-accuracy measurements of the 1S0 neutron-neutron scattering length

    International Nuclear Information System (INIS)

    Howell, C.R.; Chen, Q.; Gonzalez Trotter, D.E.; Salinas, F.; Crowell, A.S.; Roper, C.D.; Tornow, W.; Walter, R.L.; Carman, T.S.; Hussein, A.; Gibbs, W.R.; Gibson, B.F.; Morris, C.; Obst, A.; Sterbenz, S.; Whitton, M.; Mertens, G.; Moore, C.F.; Whiteley, C.R.; Pasyuk, E.; Slaus, I.; Tang, H.; Zhou, Z.; Gloeckle, W.; Witala, H.

    2000-01-01

    This paper reports two recent high-accuracy determinations of the 1 S 0 neutron-neutron scattering length, a nn . One was done at the Los Alamos National Laboratory using the π - d capture reaction to produce two neutrons with low relative momentum. The neutron-deuteron (nd) breakup reaction was used in other measurement, which was conducted at the Triangle Universities Nuclear Laboratory. The results from the two determinations were consistent with each other and with previous values obtained using the π - d capture reaction. The value obtained from the nd breakup measurements is a nn = -18.7 ± 0.1 (statistical) ± 0.6 (systematic) fm, and the value from the π - d capture experiment is a nn = -18.50 ± 0.05 ± 0.53 fm. The recommended value is a nn = -18.5 ± 0.3 fm. (author)

  7. High accuracy amplitude and phase measurements based on a double heterodyne architecture

    International Nuclear Information System (INIS)

    Zhao Danyang; Wang Guangwei; Pan Weimin

    2015-01-01

    In the digital low level RF (LLRF) system of a circular (particle) accelerator, the RF field signal is usually down converted to a fixed intermediate frequency (IF). The ratio of IF and sampling frequency determines the processing required, and differs in various LLRF systems. It is generally desirable to design a universally compatible architecture for different IFs with no change to the sampling frequency and algorithm. A new RF detection method based on a double heterodyne architecture for wide IF range has been developed, which achieves the high accuracy requirement of modern LLRF. In this paper, the relation of IF and phase error is systematically analyzed for the first time and verified by experiments. The effects of temperature drift for 16 h IF detection are inhibited by the amplitude and phase calibrations. (authors)

  8. High-accuracy biodistribution analysis of adeno-associated virus variants by double barcode sequencing.

    Science.gov (United States)

    Marsic, Damien; Méndez-Gómez, Héctor R; Zolotukhin, Sergei

    2015-01-01

    Biodistribution analysis is a key step in the evaluation of adeno-associated virus (AAV) capsid variants, whether natural isolates or produced by rational design or directed evolution. Indeed, when screening candidate vectors, accurate knowledge about which tissues are infected and how efficiently is essential. We describe the design, validation, and application of a new vector, pTR-UF50-BC, encoding a bioluminescent protein, a fluorescent protein and a DNA barcode, which can be used to visualize localization of transduction at the organism, organ, tissue, or cellular levels. In addition, by linking capsid variants to different barcoded versions of the vector and amplifying the barcode region from various tissue samples using barcoded primers, biodistribution of viral genomes can be analyzed with high accuracy and efficiency.

  9. Accuracy and high-speed technique for autoprocessing of Young's fringes

    Science.gov (United States)

    Chen, Wenyi; Tan, Yushan

    1991-12-01

    In this paper, an accurate and high-speed method for auto-processing of Young's fringes is proposed. A group of 1-D sampled intensity values along three or more different directions are taken from Young's fringes, and the fringe spacings of each direction are obtained by 1-D FFT respectively. Two directions that have smaller fringe spacing are selected from all directions. The accurate fringe spacings along these two directions are obtained by using orthogonal coherent phase detection technique (OCPD). The actual spacing and angle of Young's fringes, therefore, can be calculated. In this paper, the principle of OCPD is introduced in detail. The accuracy of the method is evaluated theoretically and experimentally.

  10. DEVELOPMENT OF COMPLEXITY, ACCURACY, AND FLUENCY IN HIGH SCHOOL STUDENTS’ WRITTEN FOREIGN LANGUAGE PRODUCTION

    Directory of Open Access Journals (Sweden)

    Bouchaib Benzehaf

    2016-11-01

    Full Text Available The present study aims to longitudinally depict the dynamic and interactive development of Complexity, Accuracy, and Fluency (CAF in multilingual learners’ L2 and L3 writing. The data sources include free writing tasks written in L2 French and L3 English by 45 high school participants over a period of four semesters. CAF dimensions are measured using a variation of Hunt’s T-units (1964. Analysis of the quantitative data obtained suggests that CAF measures develop differently for learners’ L2 French and L3 English. They increase more persistently in L3 English, and they display the characteristics of a dynamic, non-linear system characterized by ups and downs particularly in L2 French. In light of the results, we suggest more and denser longitudinal data to explore the nature of interactions between these dimensions in foreign language development, particularly at the individual level.

  11. Accuracy of thick-walled hollows during piercing on three-high mill

    International Nuclear Information System (INIS)

    Potapov, I.N.; Romantsev, B.A.; Shamanaev, V.I.; Popov, V.A.; Kharitonov, E.A.

    1975-01-01

    The results of investigations are presented concerning the accuracy of geometrical dimensions of thick-walled sleeves produced by piercing on a 100-ton trio screw rolling mill MISiS with three schemes of fixing and centering the rod. The use of a spherical thrust journal for the rod and of a long centering bushing makes it possible to diminish the non-uniformity of the wall thickness of the sleeves by 30-50%. It is established that thick-walled sleeves with accurate geometrical dimensions (nonuniformity of the wall thickness being less than 10%) can be produced if the system sleeve - mandrel - rod is highly rigid and the rod has a two- or three-fold stability margin over the length equal to that of the sleeve being pierced. The process of piercing is expedient to be carried out with increased angles of feed (14-16 deg). Blanks have been made from steel 12Kh1MF

  12. Integral equation models for image restoration: high accuracy methods and fast algorithms

    International Nuclear Information System (INIS)

    Lu, Yao; Shen, Lixin; Xu, Yuesheng

    2010-01-01

    Discrete models are consistently used as practical models for image restoration. They are piecewise constant approximations of true physical (continuous) models, and hence, inevitably impose bottleneck model errors. We propose to work directly with continuous models for image restoration aiming at suppressing the model errors caused by the discrete models. A systematic study is conducted in this paper for the continuous out-of-focus image models which can be formulated as an integral equation of the first kind. The resulting integral equation is regularized by the Lavrentiev method and the Tikhonov method. We develop fast multiscale algorithms having high accuracy to solve the regularized integral equations of the second kind. Numerical experiments show that the methods based on the continuous model perform much better than those based on discrete models, in terms of PSNR values and visual quality of the reconstructed images

  13. Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control.

    Science.gov (United States)

    Ojanperä, Ilkka; Kolmonen, Marjo; Pelander, Anna

    2012-05-01

    Clinical and forensic toxicology and doping control deal with hundreds or thousands of drugs that may cause poisoning or are abused, are illicit, or are prohibited in sports. Rapid and reliable screening for all these compounds of different chemical and pharmaceutical nature, preferably in a single analytical method, is a substantial effort for analytical toxicologists. Combined chromatography-mass spectrometry techniques with standardised reference libraries have been most commonly used for the purpose. In the last ten years, the focus has shifted from gas chromatography-mass spectrometry to liquid chromatography-mass spectrometry, because of progress in instrument technology and partly because of the polarity and low volatility of many new relevant substances. High-resolution mass spectrometry (HRMS), which enables accurate mass measurement at high resolving power, has recently evolved to the stage that is rapidly causing a shift from unit-resolution, quadrupole-dominated instrumentation. The main HRMS techniques today are time-of-flight mass spectrometry and Orbitrap Fourier-transform mass spectrometry. Both techniques enable a range of different drug-screening strategies that essentially rely on measuring a compound's or a fragment's mass with sufficiently high accuracy that its elemental composition can be determined directly. Accurate mass and isotopic pattern acts as a filter for confirming the identity of a compound or even identification of an unknown. High mass resolution is essential for improving confidence in accurate mass results in the analysis of complex biological samples. This review discusses recent applications of HRMS in analytical toxicology.

  14. Innovative High-Accuracy Lidar Bathymetric Technique for the Frequent Measurement of River Systems

    Science.gov (United States)

    Gisler, A.; Crowley, G.; Thayer, J. P.; Thompson, G. S.; Barton-Grimley, R. A.

    2015-12-01

    Lidar (light detection and ranging) provides absolute depth and topographic mapping capability compared to other remote sensing methods, which is useful for mapping rapidly changing environments such as riverine systems. Effectiveness of current lidar bathymetric systems is limited by the difficulty in unambiguously identifying backscattered lidar signals from the water surface versus the bottom, limiting their depth resolution to 0.3-0.5 m. Additionally these are large, bulky systems that are constrained to expensive aircraft-mounted platforms and use waveform-processing techniques requiring substantial computation time. These restrictions are prohibitive for many potential users. A novel lidar device has been developed that allows for non-contact measurements of water depth down to 1 cm with an accuracy and precision of shallow to deep water allowing for shoreline charting, measuring water volume, mapping bottom topology, and identifying submerged objects. The scalability of the technique opens up the ability for handheld or UAS-mounted lidar bathymetric systems, which provides for potential applications currently unavailable to the community. The high laser pulse repetition rate allows for very fine horizontal resolution while the photon-counting technique permits real-time depth measurement and object detection. The enhanced measurement capability, portability, scalability, and relatively low-cost creates the opportunity to perform frequent high-accuracy monitoring and measuring of aquatic environments which is crucial for understanding how rivers evolve over many timescales. Results from recent campaigns measuring water depth in flowing creeks and murky ponds will be presented which demonstrate that the method is not limited by rough water surfaces and can map underwater topology through moderately turbid water.

  15. Innovative Technique for High-Accuracy Remote Monitoring of Surface Water

    Science.gov (United States)

    Gisler, A.; Barton-Grimley, R. A.; Thayer, J. P.; Crowley, G.

    2016-12-01

    Lidar (light detection and ranging) provides absolute depth and topographic mapping capability compared to other remote sensing methods, which is useful for mapping rapidly changing environments such as riverine systems and agricultural waterways. Effectiveness of current lidar bathymetric systems is limited by the difficulty in unambiguously identifying backscattered lidar signals from the water surface versus the bottom, limiting their depth resolution to 0.3-0.5 m. Additionally these are large, bulky systems that are constrained to expensive aircraft-mounted platforms and use waveform-processing techniques requiring substantial computation time. These restrictions are prohibitive for many potential users. A novel lidar device has been developed that allows for non-contact measurements of water depth down to 1 cm with an accuracy and precision of shallow to deep water allowing for shoreline charting, measuring water volume, mapping bottom topology, and identifying submerged objects. The scalability of the technique opens up the ability for handheld or UAS-mounted lidar bathymetric systems, which provides for potential applications currently unavailable to the community. The high laser pulse repetition rate allows for very fine horizontal resolution while the photon-counting technique permits real-time depth measurement and object detection. The enhanced measurement capability, portability, scalability, and relatively low-cost creates the opportunity to perform frequent high-accuracy monitoring and measuring of aquatic environments which is crucial for monitoring water resources on fast timescales. Results from recent campaigns measuring water depth in flowing creeks and murky ponds will be presented which demonstrate that the method is not limited by rough water surfaces and can map underwater topology through moderately turbid water.

  16. High-accuracy continuous airborne measurements of greenhouse gases (CO2 and CH4) during BARCA

    Science.gov (United States)

    Chen, H.; Winderlich, J.; Gerbig, C.; Hoefer, A.; Rella, C. W.; Crosson, E. R.; van Pelt, A. D.; Steinbach, J.; Kolle, O.; Beck, V.; Daube, B. C.; Gottlieb, E. W.; Chow, V. Y.; Santoni, G. W.; Wofsy, S. C.

    2009-12-01

    High-accuracy continuous measurements of greenhouse gases (CO2 and CH4) during the BARCA (Balanço Atmosférico Regional de Carbono na Amazônia) phase B campaign in Brazil in May 2009 were accomplished using a newly available analyzer based on the cavity ring-down spectroscopy (CRDS) technique. This analyzer was flown without a drying system or any in-flight calibration gases. Water vapor corrections associated with dilution and pressure-broadening effects for CO2 and CH4 were derived from laboratory experiments employing measurements of water vapor by the CRDS analyzer. Before the campaign, the stability of the analyzer was assessed by laboratory tests under simulated flight conditions. During the campaign, a comparison of CO2 measurements between the CRDS analyzer and a nondispersive infrared (NDIR) analyzer on board the same aircraft showed a mean difference of 0.22±0.09 ppm for all flights over the Amazon rain forest. At the end of the campaign, CO2 concentrations of the synthetic calibration gases used by the NDIR analyzer were determined by the CRDS analyzer. After correcting for the isotope and the pressure-broadening effects that resulted from changes of the composition of synthetic vs. ambient air, and applying those concentrations as calibrated values of the calibration gases to reprocess the CO2 measurements made by the NDIR, the mean difference between the CRDS and the NDIR during BARCA was reduced to 0.05±0.09 ppm, with the mean standard deviation of 0.23±0.05 ppm. The results clearly show that the CRDS is sufficiently stable to be used in flight without drying the air or calibrating in flight and the water corrections are fully adequate for high-accuracy continuous airborne measurements of CO2 and CH4.

  17. High-accuracy self-mixing interferometer based on single high-order orthogonally polarized feedback effects.

    Science.gov (United States)

    Zeng, Zhaoli; Qu, Xueming; Tan, Yidong; Tan, Runtao; Zhang, Shulian

    2015-06-29

    A simple and high-accuracy self-mixing interferometer based on single high-order orthogonally polarized feedback effects is presented. The single high-order feedback effect is realized when dual-frequency laser reflects numerous times in a Fabry-Perot cavity and then goes back to the laser resonator along the same route. In this case, two orthogonally polarized feedback fringes with nanoscale resolution are obtained. This self-mixing interferometer has the advantages of higher sensitivity to weak signal than that of conventional interferometer. In addition, two orthogonally polarized fringes are useful for discriminating the moving direction of measured object. The experiment of measuring 2.5nm step is conducted, which shows a great potential in nanometrology.

  18. High resolution study of high mass pairs and high transverse momentum particles

    International Nuclear Information System (INIS)

    Smith, S.R.

    1983-01-01

    Preliminary experiments involving the high resolution spectrometer (experiment 605) at Fermilab are described. The spectrometer is designed for the study of pairs of particles at large invariant masses and single particles at large transverse momenta. A number of applications of the apparatus in the study of Drell-Yan processes, e.g. transverse momentum measurement, are discussed

  19. Prediction of renal function (GFR) from cystatin C and creatinine in children: Body cell mass increases accuracy of the estimate

    DEFF Research Database (Denmark)

    Andersen, Trine Borup; Jødal, Lars; Bøgsted, Martin

    using robust regression in a forward, stepwise procedure. GFR (mL/min) was the dependent variable. The accuracy and precision of the prediction model were compared to other prediction models from the literature, using k-fold cross-validation. Local constants and coefficients were calculated for all...

  20. Evaluation of high-resolution mass spectrometry for urine toxicology screening in a pain management setting.

    Science.gov (United States)

    Crews, Bridgit O; Pesce, Amadeo J; West, Robert; Nguyen, Hugh; Fitzgerald, Robert L

    2012-01-01

    To evaluate liquid chromatography-high-resolution mass spectrometry (LC-HR-MS) for urine toxicology screening, 29 analytes were quantitated in 152 urine specimens from patients with chronic pain using two unique mass spectrometry platforms. De-identified specimens were quantitated in April of 2011 by liquid chromatography-triple quadrupole mass spectrometry (LC-MS-MS) and by full-scan LC-HR-MS at Millennium Laboratories. Considering LC-MS-MS as the reference method, false positive results were identified in 19 specimens measured by LC-HR-MS. Application of relative retention times using deuterium labeled internal standards improved the rate of false positive detection to only five specimens, with four occurring for the same analyte. Ultra-high-resolution mass spectrometry (R = 100,000 at m/z 200) showed no improvement over high-resolution mass spectrometry (R = 10,000 at m/z 200) in the number of false positives detected. Quantitative results measured by LC-MS-MS and LC-HR-MS showed good agreement over four orders of dynamic range. This study demonstrates that LC-HR-MS is a suitable platform for toxicology screening for a pain management population and that quantitative accuracy and sensitivity are comparable to that achieved with LC-MS-MS. The specificity of LC-HR-MS is improved by the addition of deuterium labeled internal standards and the implementation of relative retention time matching.

  1. Accuracy assessment of high resolution satellite imagery orientation by leave-one-out method

    Science.gov (United States)

    Brovelli, Maria Antonia; Crespi, Mattia; Fratarcangeli, Francesca; Giannone, Francesca; Realini, Eugenio

    Interest in high-resolution satellite imagery (HRSI) is spreading in several application fields, at both scientific and commercial levels. Fundamental and critical goals for the geometric use of this kind of imagery are their orientation and orthorectification, processes able to georeference the imagery and correct the geometric deformations they undergo during acquisition. In order to exploit the actual potentialities of orthorectified imagery in Geomatics applications, the definition of a methodology to assess the spatial accuracy achievable from oriented imagery is a crucial topic. In this paper we want to propose a new method for accuracy assessment based on the Leave-One-Out Cross-Validation (LOOCV), a model validation method already applied in different fields such as machine learning, bioinformatics and generally in any other field requiring an evaluation of the performance of a learning algorithm (e.g. in geostatistics), but never applied to HRSI orientation accuracy assessment. The proposed method exhibits interesting features which are able to overcome the most remarkable drawbacks involved by the commonly used method (Hold-Out Validation — HOV), based on the partitioning of the known ground points in two sets: the first is used in the orientation-orthorectification model (GCPs — Ground Control Points) and the second is used to validate the model itself (CPs — Check Points). In fact the HOV is generally not reliable and it is not applicable when a low number of ground points is available. To test the proposed method we implemented a new routine that performs the LOOCV in the software SISAR, developed by the Geodesy and Geomatics Team at the Sapienza University of Rome to perform the rigorous orientation of HRSI; this routine was tested on some EROS-A and QuickBird images. Moreover, these images were also oriented using the world recognized commercial software OrthoEngine v. 10 (included in the Geomatica suite by PCI), manually performing the LOOCV

  2. High-Accuracy Measurements of Total Column Water Vapor From the Orbiting Carbon Observatory-2

    Science.gov (United States)

    Nelson, Robert R.; Crisp, David; Ott, Lesley E.; O'Dell, Christopher W.

    2016-01-01

    Accurate knowledge of the distribution of water vapor in Earth's atmosphere is of critical importance to both weather and climate studies. Here we report on measurements of total column water vapor (TCWV) from hyperspectral observations of near-infrared reflected sunlight over land and ocean surfaces from the Orbiting Carbon Observatory-2 (OCO-2). These measurements are an ancillary product of the retrieval algorithm used to measure atmospheric carbon dioxide concentrations, with information coming from three highly resolved spectral bands. Comparisons to high-accuracy validation data, including ground-based GPS and microwave radiometer data, demonstrate that OCO-2 TCWV measurements have maximum root-mean-square deviations of 0.9-1.3mm. Our results indicate that OCO-2 is the first space-based sensor to accurately and precisely measure the two most important greenhouse gases, water vapor and carbon dioxide, at high spatial resolution [1.3 x 2.3 km(exp. 2)] and that OCO-2 TCWV measurements may be useful in improving numerical weather predictions and reanalysis products.

  3. Design and Performance Evaluation of Real-time Endovascular Interventional Surgical Robotic System with High Accuracy.

    Science.gov (United States)

    Wang, Kundong; Chen, Bing; Lu, Qingsheng; Li, Hongbing; Liu, Manhua; Shen, Yu; Xu, Zhuoyan

    2018-05-15

    Endovascular interventional surgery (EIS) is performed under a high radiation environment at the sacrifice of surgeons' health. This paper introduces a novel endovascular interventional surgical robot that aims to reduce radiation to surgeons and physical stress imposed by lead aprons during fluoroscopic X-ray guided catheter intervention. The unique mechanical structure allowed the surgeon to manipulate the axial and radial motion of the catheter and guide wire. Four catheter manipulators (to manipulate the catheter and guide wire), and a control console which consists of four joysticks, several buttons and two twist switches (to control the catheter manipulators) were presented. The entire robotic system was established on a master-slave control structure through CAN (Controller Area Network) bus communication, meanwhile, the slave side of this robotic system showed highly accurate control over velocity and displacement with PID controlling method. The robotic system was tested and passed in vitro and animal experiments. Through functionality evaluation, the manipulators were able to complete interventional surgical motion both independently and cooperatively. The robotic surgery was performed successfully in an adult female pig and demonstrated the feasibility of superior mesenteric and common iliac artery stent implantation. The entire robotic system met the clinical requirements of EIS. The results show that the system has the ability to imitate the movements of surgeons and to accomplish the axial and radial motions with consistency and high-accuracy. Copyright © 2018 John Wiley & Sons, Ltd.

  4. Ultra High-Mass Resolution Paper Spray by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Kevin D. Quinn

    2012-01-01

    Full Text Available Paper Spray Ionization is an atmospheric pressure ionization technique that utilizes an offline electro-osmotic flow to generate ions off a paper medium. This technique can be performed on a Bruker SolariX Fourier transform ion cyclotron resonance mass spectrometer by modifying the existing nanospray source. High-resolution paper spray spectra were obtained for both organic and biological samples to demonstrate the benefit of linking the technique with a high-resolution mass analyzer. Error values in the range 0.23 to 2.14 ppm were obtained for calf lung surfactant extract with broadband mass resolving power (m/Δm50% above 60,000 utilizing an external calibration standard.

  5. A Robust High-Accuracy Ultrasound Indoor Positioning System Based on a Wireless Sensor Network.

    Science.gov (United States)

    Qi, Jun; Liu, Guo-Ping

    2017-11-06

    This paper describes the development and implementation of a robust high-accuracy ultrasonic indoor positioning system (UIPS). The UIPS consists of several wireless ultrasonic beacons in the indoor environment. Each of them has a fixed and known position coordinate and can collect all the transmissions from the target node or emit ultrasonic signals. Every wireless sensor network (WSN) node has two communication modules: one is WiFi, that transmits the data to the server, and the other is the radio frequency (RF) module, which is only used for time synchronization between different nodes, with accuracy up to 1 μ s. The distance between the beacon and the target node is calculated by measuring the time-of-flight (TOF) for the ultrasonic signal, and then the position of the target is computed by some distances and the coordinate of the beacons. TOF estimation is the most important technique in the UIPS. A new time domain method to extract the envelope of the ultrasonic signals is presented in order to estimate the TOF. This method, with the envelope detection filter, estimates the value with the sampled values on both sides based on the least squares method (LSM). The simulation results show that the method can achieve envelope detection with a good filtering effect by means of the LSM. The highest precision and variance can reach 0.61 mm and 0.23 mm, respectively, in pseudo-range measurements with UIPS. A maximum location error of 10.2 mm is achieved in the positioning experiments for a moving robot, when UIPS works on the line-of-sight (LOS) signal.

  6. High-accuracy optical extensometer based on coordinate transform in two-dimensional digital image correlation

    Science.gov (United States)

    Lv, Zeqian; Xu, Xiaohai; Yan, Tianhao; Cai, Yulong; Su, Yong; Zhang, Qingchuan

    2018-01-01

    In the measurement of plate specimens, traditional two-dimensional (2D) digital image correlation (DIC) is challenged by two aspects: (1) the slant optical axis (misalignment of the optical camera axis and the object surface) and (2) out-of-plane motions (including translations and rotations) of the specimens. There are measurement errors in the results measured by 2D DIC, especially when the out-of-plane motions are big enough. To solve this problem, a novel compensation method has been proposed to correct the unsatisfactory results. The proposed compensation method consists of three main parts: 1) a pre-calibration step is used to determine the intrinsic parameters and lens distortions; 2) a compensation panel (a rigid panel with several markers located at known positions) is mounted to the specimen to track the specimen's motion so that the relative coordinate transformation between the compensation panel and the 2D DIC setup can be calculated using the coordinate transform algorithm; 3) three-dimensional world coordinates of measuring points on the specimen can be reconstructed via the coordinate transform algorithm and used to calculate deformations. Simulations have been carried out to validate the proposed compensation method. Results come out that when the extensometer length is 400 pixels, the strain accuracy reaches 10 με no matter out-of-plane translations (less than 1/200 of the object distance) nor out-of-plane rotations (rotation angle less than 5°) occur. The proposed compensation method leads to good results even when the out-of-plane translation reaches several percents of the object distance or the out-of-plane rotation angle reaches tens of degrees. The proposed compensation method has been applied in tensile experiments to obtain high-accuracy results as well.

  7. A Robust High-Accuracy Ultrasound Indoor Positioning System Based on a Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Jun Qi

    2017-11-01

    Full Text Available This paper describes the development and implementation of a robust high-accuracy ultrasonic indoor positioning system (UIPS. The UIPS consists of several wireless ultrasonic beacons in the indoor environment. Each of them has a fixed and known position coordinate and can collect all the transmissions from the target node or emit ultrasonic signals. Every wireless sensor network (WSN node has two communication modules: one is WiFi, that transmits the data to the server, and the other is the radio frequency (RF module, which is only used for time synchronization between different nodes, with accuracy up to 1 μs. The distance between the beacon and the target node is calculated by measuring the time-of-flight (TOF for the ultrasonic signal, and then the position of the target is computed by some distances and the coordinate of the beacons. TOF estimation is the most important technique in the UIPS. A new time domain method to extract the envelope of the ultrasonic signals is presented in order to estimate the TOF. This method, with the envelope detection filter, estimates the value with the sampled values on both sides based on the least squares method (LSM. The simulation results show that the method can achieve envelope detection with a good filtering effect by means of the LSM. The highest precision and variance can reach 0.61 mm and 0.23 mm, respectively, in pseudo-range measurements with UIPS. A maximum location error of 10.2 mm is achieved in the positioning experiments for a moving robot, when UIPS works on the line-of-sight (LOS signal.

  8. High accuracy electromagnetic field solvers for cylindrical waveguides and axisymmetric structures using the finite element method

    International Nuclear Information System (INIS)

    Nelson, E.M.

    1993-12-01

    Some two-dimensional finite element electromagnetic field solvers are described and tested. For TE and TM modes in homogeneous cylindrical waveguides and monopole modes in homogeneous axisymmetric structures, the solvers find approximate solutions to a weak formulation of the wave equation. Second-order isoparametric lagrangian triangular elements represent the field. For multipole modes in axisymmetric structures, the solver finds approximate solutions to a weak form of the curl-curl formulation of Maxwell's equations. Second-order triangular edge elements represent the radial (ρ) and axial (z) components of the field, while a second-order lagrangian basis represents the azimuthal (φ) component of the field weighted by the radius ρ. A reduced set of basis functions is employed for elements touching the axis. With this basis the spurious modes of the curl-curl formulation have zero frequency, so spurious modes are easily distinguished from non-static physical modes. Tests on an annular ring, a pillbox and a sphere indicate the solutions converge rapidly as the mesh is refined. Computed eigenvalues with relative errors of less than a few parts per million are obtained. Boundary conditions for symmetric, periodic and symmetric-periodic structures are discussed and included in the field solver. Boundary conditions for structures with inversion symmetry are also discussed. Special corner elements are described and employed to improve the accuracy of cylindrical waveguide and monopole modes with singular fields at sharp corners. The field solver is applied to three problems: (1) cross-field amplifier slow-wave circuits, (2) a detuned disk-loaded waveguide linear accelerator structure and (3) a 90 degrees overmoded waveguide bend. The detuned accelerator structure is a critical application of this high accuracy field solver. To maintain low long-range wakefields, tight design and manufacturing tolerances are required

  9. Model Accuracy Comparison for High Resolution Insar Coherence Statistics Over Urban Areas

    Science.gov (United States)

    Zhang, Yue; Fu, Kun; Sun, Xian; Xu, Guangluan; Wang, Hongqi

    2016-06-01

    The interferometric coherence map derived from the cross-correlation of two complex registered synthetic aperture radar (SAR) images is the reflection of imaged targets. In many applications, it can act as an independent information source, or give additional information complementary to the intensity image. Specially, the statistical properties of the coherence are of great importance in land cover classification, segmentation and change detection. However, compared to the amount of work on the statistical characters of SAR intensity, there are quite fewer researches on interferometric SAR (InSAR) coherence statistics. And to our knowledge, all of the existing work that focuses on InSAR coherence statistics, models the coherence with Gaussian distribution with no discrimination on data resolutions or scene types. But the properties of coherence may be different for different data resolutions and scene types. In this paper, we investigate on the coherence statistics for high resolution data over urban areas, by making a comparison of the accuracy of several typical statistical models. Four typical land classes including buildings, trees, shadow and roads are selected as the representatives of urban areas. Firstly, several regions are selected from the coherence map manually and labelled with their corresponding classes respectively. Then we try to model the statistics of the pixel coherence for each type of region, with different models including Gaussian, Rayleigh, Weibull, Beta and Nakagami. Finally, we evaluate the model accuracy for each type of region. The experiments on TanDEM-X data show that the Beta model has a better performance than other distributions.

  10. MODEL ACCURACY COMPARISON FOR HIGH RESOLUTION INSAR COHERENCE STATISTICS OVER URBAN AREAS

    Directory of Open Access Journals (Sweden)

    Y. Zhang

    2016-06-01

    Full Text Available The interferometric coherence map derived from the cross-correlation of two complex registered synthetic aperture radar (SAR images is the reflection of imaged targets. In many applications, it can act as an independent information source, or give additional information complementary to the intensity image. Specially, the statistical properties of the coherence are of great importance in land cover classification, segmentation and change detection. However, compared to the amount of work on the statistical characters of SAR intensity, there are quite fewer researches on interferometric SAR (InSAR coherence statistics. And to our knowledge, all of the existing work that focuses on InSAR coherence statistics, models the coherence with Gaussian distribution with no discrimination on data resolutions or scene types. But the properties of coherence may be different for different data resolutions and scene types. In this paper, we investigate on the coherence statistics for high resolution data over urban areas, by making a comparison of the accuracy of several typical statistical models. Four typical land classes including buildings, trees, shadow and roads are selected as the representatives of urban areas. Firstly, several regions are selected from the coherence map manually and labelled with their corresponding classes respectively. Then we try to model the statistics of the pixel coherence for each type of region, with different models including Gaussian, Rayleigh, Weibull, Beta and Nakagami. Finally, we evaluate the model accuracy for each type of region. The experiments on TanDEM-X data show that the Beta model has a better performance than other distributions.

  11. Rotation of the Mass Donors in High-mass X-ray Binaries and Symbiotic Stars

    Directory of Open Access Journals (Sweden)

    K. Stoyanov

    2015-02-01

    Full Text Available Our aim is to investigate the tidal interaction in High-mass X-ray Binaries and Symbiotic stars in order to determine in which objects the rotation of the mass donors is synchronized or pseudosynchronized with the orbital motion of the compact companion. We find that the Be/X-ray binaries are not synchronized and the orbital periods of the systems are greater than the rotational periods of the mass donors. The giant and supergiant High-mass X-ray binaries and symbiotic stars are close to synchronization. We compare the rotation of mass donors in symbiotics with the projected rotational velocities of field giants and find that the M giants in S-type symbiotics rotate on average 1.5 times faster than the field M giants. We find that the projected rotational velocity of the red giant in symbiotic star MWC 560 is v sin i= 8.2±1.5 km.s−1, and estimate its rotational period to be Prot<>/sub = 144 - 306 days. Using the theoretical predictions of tidal interaction and pseudosynchronization, we estimate the orbital eccentricity e = 0.68 − 0.82.

  12. Novel strategy for the determination of illegal adulterants in health foods and herbal medicines using high-performance liquid chromatography with high-resolution mass spectrometry.

    Science.gov (United States)

    Wang, Zhe; Wu, Caisheng; Wang, Gangli; Zhang, Qingsheng; Zhang, Jinlan

    2015-03-01

    The detection, confirmation, and quantification of multiple illegal adulterants in health foods and herbal medicines by using a single analytical method are a challenge. This paper reports on a new strategy to meet this challenge by employing high-performance liquid chromatography coupled with high-resolution mass spectrometry and a mass spectral tree similarity filter technique. This analytical method can rapidly collect high-resolution, high-accuracy, optionally multistage mass data for compounds in samples. After a preliminary screening by retention time and high-resolution mass spectral data, known illegal adulterants can be detected. The mass spectral tree similarity filter technique has been applied to rapidly confirm these adulterants and simultaneously discover unknown ones. By using full-scan mass spectra as stem and data-dependent subsequent stage mass spectra to form branches, mass spectrometry data from detected compounds are converted into mass spectral trees. The known or unknown illegal adulterants in the samples are confirmed or discovered based on the similarity between their mass spectral trees and those of the references in a library, and they are finally quantified against standard curves. This new strategy has been tested by using 50 samples, and the illegal adulterants were rapidly and effectively detected, confirmed and quantified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. The One to Multiple Automatic High Accuracy Registration of Terrestrial LIDAR and Optical Images

    Science.gov (United States)

    Wang, Y.; Hu, C.; Xia, G.; Xue, H.

    2018-04-01

    The registration of ground laser point cloud and close-range image is the key content of high-precision 3D reconstruction of cultural relic object. In view of the requirement of high texture resolution in the field of cultural relic at present, The registration of point cloud and image data in object reconstruction will result in the problem of point cloud to multiple images. In the current commercial software, the two pairs of registration of the two kinds of data are realized by manually dividing point cloud data, manual matching point cloud and image data, manually selecting a two - dimensional point of the same name of the image and the point cloud, and the process not only greatly reduces the working efficiency, but also affects the precision of the registration of the two, and causes the problem of the color point cloud texture joint. In order to solve the above problems, this paper takes the whole object image as the intermediate data, and uses the matching technology to realize the automatic one-to-one correspondence between the point cloud and multiple images. The matching of point cloud center projection reflection intensity image and optical image is applied to realize the automatic matching of the same name feature points, and the Rodrigo matrix spatial similarity transformation model and weight selection iteration are used to realize the automatic registration of the two kinds of data with high accuracy. This method is expected to serve for the high precision and high efficiency automatic 3D reconstruction of cultural relic objects, which has certain scientific research value and practical significance.

  14. High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy

    International Nuclear Information System (INIS)

    McEvoy, Sinead; Lavelle, Lisa; Kilcoyne, Aoife; McCarthy, Colin; Dodd, Jonathan D.; DeJong, Pim A.; Loeve, Martine; Tiddens, Harm A.W.M.; McKone, Edward; Gallagher, Charles G.

    2012-01-01

    To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) for the detection of nontuberculous mycobacterium infection (NTM) in adult cystic fibrosis (CF) patients. Twenty-seven CF patients with sputum-culture-proven NTM (NTM+) underwent HRCT. An age, gender and spirometrically matched group of 27 CF patients without NTM (NTM-) was included as controls. Images were randomly and blindly analysed by two readers in consensus and scored using a modified Bhalla scoring system. Significant differences were seen between NTM (+) and NTM (-) patients in the severity of the bronchiectasis subscore [45 % (1.8/4) vs. 35 % (1.4/4), P = 0.029], collapse/consolidation subscore [33 % (1.3/3) vs. 15 % (0.6/3)], tree-in-bud/centrilobular nodules subscore [43 % (1.7/3) vs. 25 % (1.0/3), P = 0.002] and the total CT score [56 % (18.4/33) vs. 46 % (15.2/33), P = 0.002]. Binary logistic regression revealed BMI, peribronchial thickening, collapse/consolidation and tree-in-bud/centrilobular nodules to be predictors of NTM status (R 2 = 0.43). Receiver-operator curve analysis of the regression model showed an area under the curve of 0.89, P < 0.0001. In adults with CF, seven or more bronchopulmonary segments showing tree-in-bud/centrilobular nodules on HRCT is highly suggestive of NTM colonisation. (orig.)

  15. High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy

    Energy Technology Data Exchange (ETDEWEB)

    McEvoy, Sinead; Lavelle, Lisa; Kilcoyne, Aoife; McCarthy, Colin; Dodd, Jonathan D. [St. Vincent' s University Hospital, Department of Radiology, Dublin (Ireland); DeJong, Pim A. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Loeve, Martine; Tiddens, Harm A.W.M. [Erasmus MC-Sophia Children' s Hospital, Department of Radiology, Department of Pediatric Pulmonology and Allergology, Rotterdam (Netherlands); McKone, Edward; Gallagher, Charles G. [St. Vincent' s University Hospital, Department of Respiratory Medicine and National Referral Centre for Adult Cystic Fibrosis, Dublin (Ireland)

    2012-12-15

    To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) for the detection of nontuberculous mycobacterium infection (NTM) in adult cystic fibrosis (CF) patients. Twenty-seven CF patients with sputum-culture-proven NTM (NTM+) underwent HRCT. An age, gender and spirometrically matched group of 27 CF patients without NTM (NTM-) was included as controls. Images were randomly and blindly analysed by two readers in consensus and scored using a modified Bhalla scoring system. Significant differences were seen between NTM (+) and NTM (-) patients in the severity of the bronchiectasis subscore [45 % (1.8/4) vs. 35 % (1.4/4), P = 0.029], collapse/consolidation subscore [33 % (1.3/3) vs. 15 % (0.6/3)], tree-in-bud/centrilobular nodules subscore [43 % (1.7/3) vs. 25 % (1.0/3), P = 0.002] and the total CT score [56 % (18.4/33) vs. 46 % (15.2/33), P = 0.002]. Binary logistic regression revealed BMI, peribronchial thickening, collapse/consolidation and tree-in-bud/centrilobular nodules to be predictors of NTM status (R{sup 2} = 0.43). Receiver-operator curve analysis of the regression model showed an area under the curve of 0.89, P < 0.0001. In adults with CF, seven or more bronchopulmonary segments showing tree-in-bud/centrilobular nodules on HRCT is highly suggestive of NTM colonisation. (orig.)

  16. Rigorous Training of Dogs Leads to High Accuracy in Human Scent Matching-To-Sample Performance.

    Directory of Open Access Journals (Sweden)

    Sophie Marchal

    Full Text Available Human scent identification is based on a matching-to-sample task in which trained dogs are required to compare a scent sample collected from an object found at a crime scene to that of a suspect. Based on dogs' greater olfactory ability to detect and process odours, this method has been used in forensic investigations to identify the odour of a suspect at a crime scene. The excellent reliability and reproducibility of the method largely depend on rigor in dog training. The present study describes the various steps of training that lead to high sensitivity scores, with dogs matching samples with 90% efficiency when the complexity of the scents presented during the task in the sample is similar to that presented in the in lineups, and specificity reaching a ceiling, with no false alarms in human scent matching-to-sample tasks. This high level of accuracy ensures reliable results in judicial human scent identification tests. Also, our data should convince law enforcement authorities to use these results as official forensic evidence when dogs are trained appropriately.

  17. Spline-based high-accuracy piecewise-polynomial phase-to-sinusoid amplitude converters.

    Science.gov (United States)

    Petrinović, Davor; Brezović, Marko

    2011-04-01

    We propose a method for direct digital frequency synthesis (DDS) using a cubic spline piecewise-polynomial model for a phase-to-sinusoid amplitude converter (PSAC). This method offers maximum smoothness of the output signal. Closed-form expressions for the cubic polynomial coefficients are derived in the spectral domain and the performance analysis of the model is given in the time and frequency domains. We derive the closed-form performance bounds of such DDS using conventional metrics: rms and maximum absolute errors (MAE) and maximum spurious free dynamic range (SFDR) measured in the discrete time domain. The main advantages of the proposed PSAC are its simplicity, analytical tractability, and inherent numerical stability for high table resolutions. Detailed guidelines for a fixed-point implementation are given, based on the algebraic analysis of all quantization effects. The results are verified on 81 PSAC configurations with the output resolutions from 5 to 41 bits by using a bit-exact simulation. The VHDL implementation of a high-accuracy DDS based on the proposed PSAC with 28-bit input phase word and 32-bit output value achieves SFDR of its digital output signal between 180 and 207 dB, with a signal-to-noise ratio of 192 dB. Its implementation requires only one 18 kB block RAM and three 18-bit embedded multipliers in a typical field-programmable gate array (FPGA) device. © 2011 IEEE

  18. A timing detector with pulsed high-voltage power supply for mass measurements at CSRe

    International Nuclear Information System (INIS)

    Zhang, W.; Tu, X.L.; Wang, M.; Zhang, Y.H.; Xu, H.S.; Litvinov, Yu. A.; Blaum, K.

    2014-01-01

    Accuracy of nuclear mass measurements in storage rings depends critically on the accuracy with which the revolution times of stored ions can be obtained. In such experiments, micro-channel plates (MCP) are used as timing detectors. Due to large phase space of injected secondary beams, a large number of ions cannot be stored in the ring and is lost within the first few revolutions. However, these ions interact with the detector and can saturate the MCP and thus deteriorate its performance. In order to eliminate such effects, a fast, pulsed high-voltage power supply (PHVPS) has been employed which keeps the detector switched-off during the first few revolutions. The new detector setup was taken into operation at the Experimental Cooler-Storage-Ring CSRe in Lanzhou and resulted in a significant improvement of the detector amplitude and efficiency characteristics

  19. A new processing scheme for ultra-high resolution direct infusion mass spectrometry data

    Science.gov (United States)

    Zielinski, Arthur T.; Kourtchev, Ivan; Bortolini, Claudio; Fuller, Stephen J.; Giorio, Chiara; Popoola, Olalekan A. M.; Bogialli, Sara; Tapparo, Andrea; Jones, Roderic L.; Kalberer, Markus

    2018-04-01

    High resolution, high accuracy mass spectrometry is widely used to characterise environmental or biological samples with highly complex composition enabling the identification of chemical composition of often unknown compounds. Despite instrumental advancements, the accurate molecular assignment of compounds acquired in high resolution mass spectra remains time consuming and requires automated algorithms, especially for samples covering a wide mass range and large numbers of compounds. A new processing scheme is introduced implementing filtering methods based on element assignment, instrumental error, and blank subtraction. Optional post-processing incorporates common ion selection across replicate measurements and shoulder ion removal. The scheme allows both positive and negative direct infusion electrospray ionisation (ESI) and atmospheric pressure photoionisation (APPI) acquisition with the same programs. An example application to atmospheric organic aerosol samples using an Orbitrap mass spectrometer is reported for both ionisation techniques resulting in final spectra with 0.8% and 8.4% of the peaks retained from the raw spectra for APPI positive and ESI negative acquisition, respectively.

  20. FORMALDEHYDE MASERS: EXCLUSIVE TRACERS OF HIGH-MASS STAR FORMATION

    Energy Technology Data Exchange (ETDEWEB)

    Araya, E. D.; Brown, J. E. [Western Illinois University, Physics Department, 1 University Circle, Macomb, IL 61455 (United States); Olmi, L. [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Ortiz, J. Morales [University of Puerto Rico, Río Piedras Campus, Physical Sciences Department, P.O. Box 23323, San Juan, PR 00931 (United States); Hofner, P.; Creech-Eakman, M. J. [New Mexico Institute of Mining and Technology, Physics Department, 801 Leroy Place, Socorro, NM 87801 (United States); Kurtz, S. [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Apdo. Postal 3-72, 58089 Morelia, Michoacán (Mexico); Linz, H. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany)

    2015-11-15

    The detection of four formaldehyde (H{sub 2}CO) maser regions toward young high-mass stellar objects in the last decade, in addition to the three previously known regions, calls for an investigation of whether H{sub 2}CO masers are an exclusive tracer of young high-mass stellar objects. We report the first survey specifically focused on the search for 6 cm H{sub 2}CO masers toward non high-mass star-forming regions (non HMSFRs). The observations were conducted with the 305 m Arecibo Telescope toward 25 low-mass star-forming regions, 15 planetary nebulae and post-AGB stars, and 31 late-type stars. We detected no H{sub 2}CO emission in our sample of non HMSFRs. To check for the association between high-mass star formation and H{sub 2}CO masers, we also conducted a survey toward 22 high-mass star-forming regions from a Hi-GAL (Herschel infrared Galactic Plane Survey) sample known to harbor 6.7 GHz CH{sub 3}OH masers. We detected a new 6 cm H{sub 2}CO emission line in G32.74−0.07. This work provides further evidence that supports an exclusive association between H{sub 2}CO masers and young regions of high-mass star formation. Furthermore, we detected H{sub 2}CO absorption toward all Hi-GAL sources, and toward 24 low-mass star-forming regions. We also conducted a simultaneous survey for OH (4660, 4750, 4765 MHz), H110α (4874 MHz), HCOOH (4916 MHz), CH{sub 3}OH (5005 MHz), and CH{sub 2}NH (5289 MHz) toward 68 of the sources in our sample of non HMSFRs. With the exception of the detection of a 4765 MHz OH line toward a pre-planetary nebula (IRAS 04395+3601), we detected no other spectral line to an upper limit of 15 mJy for most sources.

  1. Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

    NARCIS (Netherlands)

    Wang, Guanbo; de Jong, Rob N; van den Bremer, Ewald T J; Parren, Paul W H I; Heck, Albert J R

    2017-01-01

    The determination of molecular weights (MWs) of heavily glycosylated proteins is seriously hampered by the physicochemical characteristics and heterogeneity of the attached carbohydrates. Glycosylation impacts protein migration during sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis

  2. Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry.

    NARCIS (Netherlands)

    Lasonder, E.; Ishihama, Y.; Andersen, J.S.; Vermunt, A.M.W.; Pain, A.; Sauerwein, R.W.; Eling, W.M.C.; Hall, N.; Waters, A.P.; Stunnenberg, H.G.; Mann, M.

    2002-01-01

    The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale,

  3. Mass spectrometry applied to high temperature chemistry, (2)

    International Nuclear Information System (INIS)

    Asano, Mitsuru; Kato, Eiichi; Sata, Toshiyuki.

    1980-01-01

    The application of mass spectrometry to high temperature chemistry is reviewed. As a blanket material for fusion reactors, the behavior of lithium has been investigated by using mass analysers. The enthalpies of the chemical reactions of metallic lithium were obtained. The enthalpies of isomolecular exchange reactions and the derived atomization energies of LiD, Li 2 D and Li 2 D 2 were also obtained by mass spectrometry. The thermomechanical character of lithium oxide was studied. The vaporization behaviors of LiCrO 2 and Li 5 FeO 4 were studied with a quadrupole mass analyser. The vaporization of cobalt from nickel alloy was studied. The evaporated ions were analysed with a mass analyser. The measurement of the vaporized molecules of metals and fused silicate was made by mass spectrometry. The activities of Fe-V system were determined by measuring the ion current ratio. The activities of Fe-V-Cr system were also obtained. The vapor pressure of phosphor from Fe-P alloys can be measured. The activity coefficients and interaction parameters for the dilute solutions of elements, such as Mn, Al, Cu, Cr, Co, Ni, Si, Ti, V, B, Zr, Mo, C, S, and P, dissolved in liquid iron are shown in a table. The activities of NaCl-KCl system were derived by measuring the ion current ratio and by monomer-dimer method. (Kato, T.)

  4. A high-resolution mass spectrometer to measure atmospheric ion composition

    Directory of Open Access Journals (Sweden)

    H. Junninen

    2010-08-01

    Full Text Available In this paper we present recent achievements on developing and testing a tool to detect the composition of ambient ions in the mass/charge range up to 2000 Th. The instrument is an Atmospheric Pressure Interface Time-of-Flight Mass Spectrometer (APi-TOF, Tofwerk AG. Its mass accuracy is better than 0.002%, and the mass resolving power is 3000 Th/Th. In the data analysis, a new efficient Matlab based set of programs (tofTools were developed, tested and used. The APi-TOF was tested both in laboratory conditions and applied to outdoor air sampling in Helsinki at the SMEAR III station. Transmission efficiency calibrations showed a throughput of 0.1–0.5% in the range 100–1300 Th for positive ions, and linearity over 3 orders of magnitude in concentration was determined. In the laboratory tests the APi-TOF detected sulphuric acid-ammonia clusters in high concentration from a nebulised sample illustrating the potential of the instrument in revealing the role of sulphuric acid clusters in atmospheric new particle formation. The APi-TOF features a high enough accuracy, resolution and sensitivity for the determination of the composition of atmospheric small ions although the total concentration of those ions is typically only 400–2000 cm−3. The atmospheric ions were identified based on their exact masses, utilizing Kendrick analysis and correlograms as well as narrowing down the potential candidates based on their proton affinities as well isotopic patterns. In Helsinki during day-time the main negative ambient small ions were inorganic acids and their clusters. The positive ions were more complex, the main compounds were (polyalkyl pyridines and – amines. The APi-TOF provides a near universal interface for atmospheric pressure sampling, and this key feature will be utilized in future laboratory and field studies.

  5. SIEMENS ADVANCED QUANTRA FTICR MASS SPECTROMETER FOR ULTRA HIGH RESOLUTION AT LOW MASS

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, W; Laura Tovo, L

    2008-07-08

    The Siemens Advanced Quantra Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometer was evaluated as an alternative instrument to large double focusing mass spectrometers for gas analysis. High resolution mass spectrometers capable of resolving the common mass isomers of the hydrogen isotopes are used to provide data for accurate loading of reservoirs and to monitor separation of tritium, deuterium, and helium. Conventional double focusing magnetic sector instruments have a resolution that is limited to about 5000. The Siemens FTICR instrument achieves resolution beyond 400,000 and could possibly resolve the tritium ion from the helium-3 ion, which differ by the weight of an electron, 0.00549 amu. Working with Y-12 and LANL, SRNL requested Siemens to modify their commercial Quantra system for low mass analysis. To achieve the required performance, Siemens had to increase the available waveform operating frequency from 5 MHz to 40 MHz and completely redesign the control electronics and software. However, they were able to use the previous ion trap, magnet, passive pump, and piezo-electric pulsed inlet valve design. NNSA invested $1M in this project and acquired four systems, two for Y-12 and one each for SRNL and LANL. Siemens claimed a $10M investment in the Quantra systems. The new Siemens Advanced Quantra demonstrated phenomenal resolution in the low mass range. Resolution greater than 400,000 was achieved for mass 2. The new spectrometer had a useful working mass range to 500 Daltons. However, experiments found that a continuous single scan from low mass to high was not possible. Two useful working ranges were established covering masses 1 to 6 and masses 12 to 500 for our studies. A compromise performance condition enabled masses 1 to 45 to be surveyed. The instrument was found to have a dynamic range of about three orders of magnitude and quantitative analysis is expected to be limited to around 5 percent without using complex fitting algorithms

  6. Yeast expression proteomics by high-resolution mass spectrometry

    DEFF Research Database (Denmark)

    Walther, Tobias C; Olsen, Jesper Velgaard; Mann, Matthias

    2010-01-01

    -translational controls contribute majorly to regulation of protein abundance, for example in heat shock stress response. The development of new sample preparation methods, high-resolution mass spectrometry and novel bioinfomatic tools close this gap and allow the global quantitation of the yeast proteome under different...

  7. High-Performance Liquid Chromatography-Mass Spectrometry.

    Science.gov (United States)

    Vestal, Marvin L.

    1984-01-01

    Reviews techniques for online coupling of high-performance liquid chromatography with mass spectrometry, emphasizing those suitable for application to nonvolatile samples. Also summarizes the present status, strengths, and weaknesses of various techniques and discusses potential applications of recently developed techniques for combined liquid…

  8. High-mass stars in Milky Way clusters

    Science.gov (United States)

    Negueruela, Ignacio

    2017-11-01

    Young open clusters are our laboratories for studying high-mass star formation and evolution. Unfortunately, the information that they provide is difficult to interpret, and sometimes contradictory. In this contribution, I present a few examples of the uncertainties that we face when confronting observations with theoretical models and our own assumptions.

  9. Aluminum nano-cantilevers for high sensitivity mass sensors

    DEFF Research Database (Denmark)

    Davis, Zachary James; Boisen, Anja

    2005-01-01

    We have fabricated Al nano-cantilevers using a very simple one mask contact UV lithography technique with lateral dimensions under 500 nm and vertical dimensions of approximately 100 nm. These devices are demonstrated as highly sensitive mass sensors by measuring their dynamic properties. Further...

  10. High Resolution Mass Spectrometry of Polyfluorinated Polyether-Based Formulation

    Science.gov (United States)

    Dimzon, Ian Ken; Trier, Xenia; Frömel, Tobias; Helmus, Rick; Knepper, Thomas P.; de Voogt, Pim

    2016-02-01

    High resolution mass spectrometry (HRMS) was successfully applied to elucidate the structure of a polyfluorinated polyether (PFPE)-based formulation. The mass spectrum generated from direct injection into the MS was examined by identifying the different repeating units manually and with the aid of an instrument data processor. Highly accurate mass spectral data enabled the calculation of higher-order mass defects. The different plots of MW and the nth-order mass defects (up to n = 3) could aid in assessing the structure of the different repeating units and estimating their absolute and relative number per molecule. The three major repeating units were -C2H4O-, -C2F4O-, and -CF2O-. Tandem MS was used to identify the end groups that appeared to be phosphates, as well as the possible distribution of the repeating units. Reversed-phase HPLC separated of the polymer molecules on the basis of number of nonpolar repeating units. The elucidated structure resembles the structure in the published manufacturer technical data. This analytical approach to the characterization of a PFPE-based formulation can serve as a guide in analyzing not just other PFPE-based formulations but also other fluorinated and non-fluorinated polymers. The information from MS is essential in studying the physico-chemical properties of PFPEs and can help in assessing the risks they pose to the environment and to human health.

  11. High- and low-molecular-mass microbial surfactants.

    Science.gov (United States)

    Rosenberg, E; Ron, E Z

    1999-08-01

    Microorganisms synthesize a wide variety of high- and low-molecular-mass bioemulsifiers. The low-molecular-mass bioemulsifiers are generally glycolipids, such as trehalose lipids, sophorolipids and rhamnolipids, or lipopeptides, such as surfactin, gramicidin S and polymyxin. The high-molecular-mass bioemulsifiers are amphipathic polysaccharides, proteins, lipopolysaccharides, lipoproteins or complex mixtures of these biopolymers. The low-molecular-mass bioemulsifiers lower surface and interfacial tensions, whereas the higher-molecular-mass bioemulsifiers are more effective at stabilizing oil-in-water emulsions. Three natural roles for bioemulsifiers have been proposed: (i) increasing the surface area of hydrophobic water-insoluble growth substrates; (ii) increasing the bioavailability of hydrophobic substrates by increasing their apparent solubility or desorbing them from surfaces; (iii) regulating the attachment and detachment of microorganisms to and from surfaces. Bioemulsifiers have several important advantages over chemical surfactants, which should allow them to become prominent in industrial and environmental applications. The potential commercial applications of bioemulsifiers include bioremediation of oil-polluted soil and water, enhanced oil recovery, replacement of chlorinated solvents used in cleaning-up oil-contaminated pipes, vessels and machinery, use in the detergent industry, formulations of herbicides and pesticides and formation of stable oil-in-water emulsions for the food and cosmetic industries.

  12. Application of tuned mass dampers in high-rise construction

    Science.gov (United States)

    Teplyshev, Vyacheslav; Mylnik, Alexey; Pushkareva, Maria; Agakhanov, Murad; Burova, Olga

    2018-03-01

    The article considers the use of tuned mass dampers in high-rise construction for significant acceleration and amplitude of vibrations of the upper floors under dynamic wind influences. The susceptibility of people to accelerations in high-rise buildings and possible means of reducing wind-induced fluctuations in buildings are analyzed. The statistics of application of tuned mass dampers in high-rise construction all over the world is presented. The goal of the study is to identify an economically attractive solution that allows the fullest use of the potential of building structures in high-rise construction, abandoning the need to build massive frames leading to over-consumption of materials.

  13. An ATLAS event with a high mass dijet system

    CERN Multimedia

    ATLAS, Experiment

    2014-01-01

    Event with a high mass dijet system: the invariant mass of the two highest-pT jets is 2.55 TeV. The highest pT jet has a pT of 420 GeV, and an eta of -1.51, the second leading jet has pT of 320 GeV and an eta of 2.32. Jet momenta are calibrated according to the "EM+JES" scheme. No other jets are found with pT above 20 GeV. Event collected on 4 July 2010.

  14. Design and simulation of high accuracy power supplies for injector synchrotron dipole magnets

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1991-01-01

    The ring magnet of the injector synchrotron consists of 68 dipole magnets. These magnets are connected in series and are energized from two feed points 180 degrees apart by two identical 12-phase power supplies. The current in the magnet will be raised linearly at about 1 kA level, and after a small transition period (1 ms to 10 ms typical) the current will be reduced to below the injection level of 60 A. The repetition time for the current waveform is 500 ms. A relatively fast voltage loop along with a high gain current loop are utilized to control the current in the magnet with the required accuracy. Only one regulator circuit is used to control the firing pulses of the two sets of identical 12-phase power supplies. Pspice software was used to design and simulate the power supply performance under ramping and investigate the effect of current changes on the utility voltage and input power factor. A current ripple of ±2x10 -4 and tracking error of ±5x10 -4 was needed. 3 refs., 5 figs

  15. High accuracy line positions of the ν 1 fundamental band of 14 N 2 16 O

    KAUST Repository

    Alsaif, Bidoor

    2018-03-08

    The ν1 fundamental band of N2O is examined by a novel spectrometer that relies on the frequency locking of an external-cavity quantum cascade laser around 7.8 μm to a near-infrared Tm:based frequency comb at 1.9 μm. Due to the large tunability, nearly 70 lines in the 1240 – 1310 cm−1 range of the ν1 band of N2O, from P(40) to R(31), are for the first time measured with an absolute frequency calibration and an uncertainty from 62 to 180 kHz, depending on the line. Accurate values of the spectroscopic constants of the upper state are derived from a fit of the line centers (rms ≈ 4.8 × 10−6 cm−1 or 144 kHz). The ν1 transitions presently measured in a Doppler regime validate high accuracy predictions based on sub-Doppler measurements of the ν3 and ν3-ν1 transitions.

  16. Coronary CT angiography using prospective ECG triggering. High diagnostic accuracy with low radiation dose

    International Nuclear Information System (INIS)

    Arnoldi, E.; Ramos-Duran, L.; Abro, J.A.; Costello, P.; Zwerner, P.L.; Schoepf, U.J.; Nikolaou, K.; Reiser, M.F.

    2010-01-01

    The purpose of this study was to evaluate the diagnostic performance of coronary CT angiography (coronary CTA) using prospective ECG triggering (PT) for the detection of significant coronary artery stenosis compared to invasive coronary angiography (ICA). A total of 20 patients underwent coronary CTA with PT using a 128-slice CT scanner (Definition trademark AS+, Siemens) and ICA. All coronary CTA studies were evaluated for significant coronary artery stenoses (≥50% luminal narrowing) by 2 observers in consensus using the AHA-15-segment model. Findings in CTA were compared to those in ICA. Coronary CTA using PT had 88% sensitivity in comparison to 100% with ICA, 95% to 88% specificity, 80% to 92% positive predictive value and 97% to 100% negative predictive value for diagnosing significant coronary artery stenosis on per segment per patient analysis, respectively. Mean effective radiation dose-equivalent of CTA was 2.6±1 mSv. Coronary CTA using PT enables non-invasive diagnosis of significant coronary artery stenosis with high diagnostic accuracy in comparison to ICA and is associated with comparably low radiation exposure. (orig.) [de

  17. High accuracy line positions of the ν1 fundamental band of 14N216O

    Science.gov (United States)

    AlSaif, Bidoor; Lamperti, Marco; Gatti, Davide; Laporta, Paolo; Fermann, Martin; Farooq, Aamir; Lyulin, Oleg; Campargue, Alain; Marangoni, Marco

    2018-05-01

    The ν1 fundamental band of N2O is examined by a novel spectrometer that relies on the frequency locking of an external-cavity quantum cascade laser around 7.8 μm to a near-infrared Tm:based frequency comb at 1.9 μm. Due to the large tunability, nearly 70 lines in the 1240-1310 cm-1 range of the ν1 band of N2O, from P(40) to R(31), are for the first time measured with an absolute frequency calibration and an uncertainty from 62 to 180 kHz, depending on the line. Accurate values of the spectroscopic constants of the upper state are derived from a fit of the line centers (rms ≈ 4.8 × 10-6 cm-1 or 144 kHz). The ν1 transitions presently measured in a Doppler regime validate high accuracy predictions based on sub-Doppler measurements of the ν3 and ν3-ν1 transitions.

  18. On the impact of improved dosimetric accuracy on head and neck high dose rate brachytherapy.

    Science.gov (United States)

    Peppa, Vasiliki; Pappas, Eleftherios; Major, Tibor; Takácsi-Nagy, Zoltán; Pantelis, Evaggelos; Papagiannis, Panagiotis

    2016-07-01

    To study the effect of finite patient dimensions and tissue heterogeneities in head and neck high dose rate brachytherapy. The current practice of TG-43 dosimetry was compared to patient specific dosimetry obtained using Monte Carlo simulation for a sample of 22 patient plans. The dose distributions were compared in terms of percentage dose differences as well as differences in dose volume histogram and radiobiological indices for the target and organs at risk (mandible, parotids, skin, and spinal cord). Noticeable percentage differences exist between TG-43 and patient specific dosimetry, mainly at low dose points. Expressed as fractions of the planning aim dose, percentage differences are within 2% with a general TG-43 overestimation except for the spine. These differences are consistent resulting in statistically significant differences of dose volume histogram and radiobiology indices. Absolute differences of these indices are however small to warrant clinical importance in terms of tumor control or complication probabilities. The introduction of dosimetry methods characterized by improved accuracy is a valuable advancement. It does not appear however to influence dose prescription or call for amendment of clinical recommendations for the mobile tongue, base of tongue, and floor of mouth patient cohort of this study. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Design and simulation of high accuracy power supplies for injector synchrotron dipole magnets

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1991-01-01

    The ring magnet of the injector synchrotron consists of 68 dipole magnets. These magnets are connected in series and are energized from two feed points 180 degree apart by two identical 12-phase power supplies. The current in the magnet will be raised linearly to about 1 kA level, and after a small transition period (1 ms to 10 ms typical) the current will be reduced to below the injection level of 60 A. The repetition time for the current waveform is 500 ms. A relatively fast voltage loop along with a high gain current loop are utilized to control the current in the magnet with the required accuracy. Only one regulator circuit is used to control the firing pulses of the two sets of identical 12-phase power supplies. Pspice software was used to design and simulate the power supply performance under ramping and investigate the effect of current changes on the utility voltage and input power factor. A current ripple of ± 2 x 10 -4 and tracking error of ± 5 x 10 -4 was needed

  20. Quantitative accuracy of serotonergic neurotransmission imaging with high-resolution 123I SPECT

    International Nuclear Information System (INIS)

    Kuikka, J.T.

    2004-01-01

    Aim: Serotonin transporter (SERT) imaging can be used to study the role of regional abnormalities of neurotransmitter release in various mental disorders and to study the mechanism of action of therapeutic drugs or drugs' abuse. We examine the quantitative accuracy and reproducibility that can be achieved with high-resolution SPECT of serotonergic neurotransmission. Method: Binding potential (BP) of 123 I labeled tracer specific for midbrain SERT was assessed in 20 healthy persons. The effects of scatter, attenuation, partial volume, misregistration and statistical noise were estimated using phantom and human studies. Results: Without any correction, BP was underestimated by 73%. The partial volume error was the major component in this underestimation whereas the most critical error for the reproducibility was misplacement of region of interest (ROI). Conclusion: The proper ROI registration, the use of the multiple head gamma camera with transmission based scatter correction introduce more relevant results. However, due to the small dimensions of the midbrain SERT structures and poor spatial resolution of SPECT, the improvement without the partial volume correction is not great enough to restore the estimate of BP to that of the true one. (orig.) [de

  1. High Accuracy Ground-based near-Earth-asteroid Astrometry using Synthetic Tracking

    Science.gov (United States)

    Zhai, Chengxing; Shao, Michael; Saini, Navtej; Sandhu, Jagmit; Werne, Thomas; Choi, Philip; Ely, Todd A.; Jacobs, Chirstopher S.; Lazio, Joseph; Martin-Mur, Tomas J.; Owen, William M.; Preston, Robert; Turyshev, Slava; Michell, Adam; Nazli, Kutay; Cui, Isaac; Monchama, Rachel

    2018-01-01

    Accurate astrometry is crucial for determining the orbits of near-Earth-asteroids (NEAs). Further, the future of deep space high data rate communications is likely to be optical communications, such as the Deep Space Optical Communications package that is part of the baseline payload for the planned Psyche Discovery mission to the Psyche asteroid. We have recently upgraded our instrument on the Pomona College 1 m telescope, at JPL's Table Mountain Facility, for conducting synthetic tracking by taking many short exposure images. These images can be then combined in post-processing to track both asteroid and reference stars to yield accurate astrometry. Utilizing the precision of the current and future Gaia data releases, the JPL-Pomona College effort is now demonstrating precision astrometry on NEAs, which is likely to be of considerable value for cataloging NEAs. Further, treating NEAs as proxies of future spacecraft that carry optical communication lasers, our results serve as a measure of the astrometric accuracy that could be achieved for future plane-of-sky optical navigation.

  2. Optimal design of a high accuracy photoelectric auto-collimator based on position sensitive detector

    Science.gov (United States)

    Yan, Pei-pei; Yang, Yong-qing; She, Wen-ji; Liu, Kai; Jiang, Kai; Duan, Jing; Shan, Qiusha

    2018-02-01

    A kind of high accuracy Photo-electric auto-collimator based on PSD was designed. The integral structure composed of light source, optical lens group, Position Sensitive Detector (PSD) sensor, and its hardware and software processing system constituted. Telephoto objective optical type is chosen during the designing process, which effectively reduces the length, weight and volume of the optical system, as well as develops simulation-based design and analysis of the auto-collimator optical system. The technical indicators of auto-collimator presented by this paper are: measuring resolution less than 0.05″; a field of view is 2ω=0.4° × 0.4° measuring range is +/-5' error of whole range measurement is less than 0.2″. Measuring distance is 10m, which are applicable to minor-angle precise measuring environment. Aberration analysis indicates that the MTF close to the diffraction limit, the spot in the spot diagram is much smaller than the Airy disk. The total length of the telephoto lens is only 450mm by the design of the optical machine structure optimization. The autocollimator's dimension get compact obviously under the condition of the image quality is guaranteed.

  3. Review of The SIAM 100-Digit Challenge: A Study in High-Accuracy Numerical Computing

    International Nuclear Information System (INIS)

    Bailey, David

    2005-01-01

    In the January 2002 edition of SIAM News, Nick Trefethen announced the '$100, 100-Digit Challenge'. In this note he presented ten easy-to-state but hard-to-solve problems of numerical analysis, and challenged readers to find each answer to ten-digit accuracy. Trefethen closed with the enticing comment: 'Hint: They're hard. If anyone gets 50 digits in total, I will be impressed.' This challenge obviously struck a chord in hundreds of numerical mathematicians worldwide, as 94 teams from 25 nations later submitted entries. Many of these submissions exceeded the target of 50 correct digits; in fact, 20 teams achieved a perfect score of 100 correct digits. Trefethen had offered $100 for the best submission. Given the overwhelming response, a generous donor (William Browning, founder of Applied Mathematics, Inc.) provided additional funds to provide a $100 award to each of the 20 winning teams. Soon after the results were out, four participants, each from a winning team, got together and agreed to write a book about the problems and their solutions. The team is truly international: Bornemann is from Germany, Laurie is from South Africa, Wagon is from the USA, and Waldvogel is from Switzerland. This book provides some mathematical background for each problem, and then shows in detail how each of them can be solved. In fact, multiple solution techniques are mentioned in each case. The book describes how to extend these solutions to much larger problems and much higher numeric precision (hundreds or thousands of digit accuracy). The authors also show how to compute error bounds for the results, so that one can say with confidence that one's results are accurate to the level stated. Numerous numerical software tools are demonstrated in the process, including the commercial products Mathematica, Maple and Matlab. Computer programs that perform many of the algorithms mentioned in the book are provided, both in an appendix to the book and on a website. In the process, the

  4. The high mass frontier: limits on heavy neutrinos

    International Nuclear Information System (INIS)

    Gronau, M.

    1984-01-01

    The theoretical motivation for a search for heavy neutrinos is discussed followed by the presentation of typical model dependent expectations for the mixing of the latter with ordinary neutrinos. Present mass and mixing limits on such heavy neutral leptons are based on search for secondary peaks in π and K leptonic decays and on the absence of neutrino decay signatures in neutrino beams from conventional sources and beam dumps. While these limits are quite poor for masses above 1 GeV, we describe methods to extend the limits to masses in the many GeV region. Such limits may be derived from search in b decays, high statistics neutrino experiments, search in ep colliders, W and Z decays and finally - decays of very heavy gauge bosons (if such exist in the TeV region) when produced in multi-TeV pp and antipp colliders

  5. High mass-asymmetry distributions of fissioning nuclei

    International Nuclear Information System (INIS)

    Sandulescu, A.; Lusting, H.J.; Hahn, J.; Greiner, W.

    1978-07-01

    It is shown that new mass-asymmetry valleys are appearing in the fragmentation potential V(l,eta) as function of the length l and mass-asymmetry coordinate eta = (A 1 - A 2 )to a correct treatment of the shell effects such that for separated fragments the shell effects equal the sum of the shell effects of the individual fragments and correspond to the double magic fragments 48 Ca, 78 Ni, 132 Sn and 208 Pb or may be 56 Ni. Also is shown that the fission mass-distributions have additional peaks corresponding to the bottom of these new valleys. The calculations are illustrated for 252 No and 238 U. The preliminary results show for 238 U relatively high percent yields in agreement with present available experimental data. (author)

  6. Shear wave elastography for breast masses is highly reproducible.

    Science.gov (United States)

    Cosgrove, David O; Berg, Wendie A; Doré, Caroline J; Skyba, Danny M; Henry, Jean-Pierre; Gay, Joel; Cohen-Bacrie, Claude

    2012-05-01

    To evaluate intra- and interobserver reproducibility of shear wave elastography (SWE) for breast masses. For intraobserver reproducibility, each observer obtained three consecutive SWE images of 758 masses that were visible on ultrasound. 144 (19%) were malignant. Weighted kappa was used to assess the agreement of qualitative elastographic features; the reliability of quantitative measurements was assessed by intraclass correlation coefficients (ICC). For the interobserver reproducibility, a blinded observer reviewed images and agreement on features was determined. Mean age was 50 years; mean mass size was 13 mm. Qualitatively, SWE images were at least reasonably similar for 666/758 (87.9%). Intraclass correlation for SWE diameter, area and perimeter was almost perfect (ICC ≥ 0.94). Intraobserver reliability for maximum and mean elasticity was almost perfect (ICC = 0.84 and 0.87) and was substantial for the ratio of mass-to-fat elasticity (ICC = 0.77). Interobserver agreement was moderate for SWE homogeneity (κ = 0.57), substantial for qualitative colour assessment of maximum elasticity (κ = 0.66), fair for SWE shape (κ = 0.40), fair for B-mode mass margins (κ = 0.38), and moderate for B-mode mass shape (κ = 0.58), orientation (κ = 0.53) and BI-RADS assessment (κ = 0.59). SWE is highly reproducible for assessing elastographic features of breast masses within and across observers. SWE interpretation is at least as consistent as that of BI-RADS ultrasound B-mode features. • Shear wave ultrasound elastography can measure the stiffness of breast tissue • It provides a qualitatively and quantitatively interpretable colour-coded map of tissue stiffness • Intraobserver reproducibility of SWE is almost perfect while intraobserver reproducibility of SWE proved to be moderate to substantial • The most reproducible SWE features between observers were SWE image homogeneity and maximum elasticity.

  7. Achieving numerical accuracy and high performance using recursive tile LU factorization with partial pivoting

    KAUST Repository

    Dongarra, Jack

    2013-09-18

    The LU factorization is an important numerical algorithm for solving systems of linear equations in science and engineering and is a characteristic of many dense linear algebra computations. For example, it has become the de facto numerical algorithm implemented within the LINPACK benchmark to rank the most powerful supercomputers in the world, collected by the TOP500 website. Multicore processors continue to present challenges to the development of fast and robust numerical software due to the increasing levels of hardware parallelism and widening gap between core and memory speeds. In this context, the difficulty in developing new algorithms for the scientific community resides in the combination of two goals: achieving high performance while maintaining the accuracy of the numerical algorithm. This paper proposes a new approach for computing the LU factorization in parallel on multicore architectures, which not only improves the overall performance but also sustains the numerical quality of the standard LU factorization algorithm with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic as well as the atomicity of selecting the appropriate pivots. Our approach uses a parallel fine-grained recursive formulation of the panel factorization step and implements the update of the trailing submatrix with the tile algorithm. Based on conflict-free partitioning of the data and lockless synchronization mechanisms, our implementation lets the overall computation flow naturally without contention. The dynamic runtime system called QUARK is then able to schedule tasks with heterogeneous granularities and to transparently introduce algorithmic lookahead. The performance results of our implementation are competitive compared to the currently available software packages and libraries. For example

  8. Reduced Set of Virulence Genes Allows High Accuracy Prediction of Bacterial Pathogenicity in Humans

    Science.gov (United States)

    Iraola, Gregorio; Vazquez, Gustavo; Spangenberg, Lucía; Naya, Hugo

    2012-01-01

    Although there have been great advances in understanding bacterial pathogenesis, there is still a lack of integrative information about what makes a bacterium a human pathogen. The advent of high-throughput sequencing technologies has dramatically increased the amount of completed bacterial genomes, for both known human pathogenic and non-pathogenic strains; this information is now available to investigate genetic features that determine pathogenic phenotypes in bacteria. In this work we determined presence/absence patterns of different virulence-related genes among more than finished bacterial genomes from both human pathogenic and non-pathogenic strains, belonging to different taxonomic groups (i.e: Actinobacteria, Gammaproteobacteria, Firmicutes, etc.). An accuracy of 95% using a cross-fold validation scheme with in-fold feature selection is obtained when classifying human pathogens and non-pathogens. A reduced subset of highly informative genes () is presented and applied to an external validation set. The statistical model was implemented in the BacFier v1.0 software (freely available at ), that displays not only the prediction (pathogen/non-pathogen) and an associated probability for pathogenicity, but also the presence/absence vector for the analyzed genes, so it is possible to decipher the subset of virulence genes responsible for the classification on the analyzed genome. Furthermore, we discuss the biological relevance for bacterial pathogenesis of the core set of genes, corresponding to eight functional categories, all with evident and documented association with the phenotypes of interest. Also, we analyze which functional categories of virulence genes were more distinctive for pathogenicity in each taxonomic group, which seems to be a completely new kind of information and could lead to important evolutionary conclusions. PMID:22916122

  9. Achieving numerical accuracy and high performance using recursive tile LU factorization with partial pivoting

    KAUST Repository

    Dongarra, Jack; Faverge, Mathieu; Ltaief, Hatem; Luszczek, Piotr R.

    2013-01-01

    The LU factorization is an important numerical algorithm for solving systems of linear equations in science and engineering and is a characteristic of many dense linear algebra computations. For example, it has become the de facto numerical algorithm implemented within the LINPACK benchmark to rank the most powerful supercomputers in the world, collected by the TOP500 website. Multicore processors continue to present challenges to the development of fast and robust numerical software due to the increasing levels of hardware parallelism and widening gap between core and memory speeds. In this context, the difficulty in developing new algorithms for the scientific community resides in the combination of two goals: achieving high performance while maintaining the accuracy of the numerical algorithm. This paper proposes a new approach for computing the LU factorization in parallel on multicore architectures, which not only improves the overall performance but also sustains the numerical quality of the standard LU factorization algorithm with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic as well as the atomicity of selecting the appropriate pivots. Our approach uses a parallel fine-grained recursive formulation of the panel factorization step and implements the update of the trailing submatrix with the tile algorithm. Based on conflict-free partitioning of the data and lockless synchronization mechanisms, our implementation lets the overall computation flow naturally without contention. The dynamic runtime system called QUARK is then able to schedule tasks with heterogeneous granularities and to transparently introduce algorithmic lookahead. The performance results of our implementation are competitive compared to the currently available software packages and libraries. For example

  10. Ultrananocrystalline Diamond Membranes for Detection of High-Mass Proteins

    Science.gov (United States)

    Kim, H.; Park, J.; Aksamija, Z.; Arbulu, M.; Blick, R. H.

    2016-12-01

    Mechanical resonators realized on the nanoscale by now offer applications in mass sensing of biomolecules with extraordinary sensitivity. The general idea is that perfect mechanical mass sensors should be of extremely small size to achieve zepto- or yoctogram sensitivity in weighing single molecules similar to a classical scale. However, the small effective size and long response time for weighing biomolecules with a cantilever restricts their usefulness as a high-throughput method. Commercial mass spectrometry (MS), on the other hand, such as electrospray ionization and matrix-assisted laser desorption and ionization (MALDI) time of flight (TOF) and their charge-amplifying detectors are the gold standards to which nanomechanical resonators have to live up to. These two methods rely on the ionization and acceleration of biomolecules and the following ion detection after a mass selection step, such as TOF. The principle we describe here for ion detection is based on the conversion of kinetic energy of the biomolecules into thermal excitation of chemical vapor deposition diamond nanomembranes via phonons followed by phonon-mediated detection via field emission of thermally emitted electrons. We fabricate ultrathin diamond membranes with large lateral dimensions for MALDI TOF MS of high-mass proteins. These diamond membranes are realized by straightforward etching methods based on semiconductor processing. With a minimal thickness of 100 nm and cross sections of up to 400 ×400 μ m2 , the membranes offer extreme aspect ratios. Ion detection is demonstrated in MALDI TOF analysis over a broad range from insulin to albumin. The resulting data in detection show much enhanced resolution as compared to existing detectors, which can offer better sensitivity and overall performance in resolving protein masses.

  11. Factors Determining the Inter-observer Variability and Diagnostic Accuracy of High-resolution Manometry for Esophageal Motility Disorders.

    Science.gov (United States)

    Kim, Ji Hyun; Kim, Sung Eun; Cho, Yu Kyung; Lim, Chul-Hyun; Park, Moo In; Hwang, Jin Won; Jang, Jae-Sik; Oh, Minkyung

    2018-01-30

    Although high-resolution manometry (HRM) has the advantage of visual intuitiveness, its diagnostic validity remains under debate. The aim of this study was to evaluate the diagnostic accuracy of HRM for esophageal motility disorders. Six staff members and 8 trainees were recruited for the study. In total, 40 patients enrolled in manometry studies at 3 institutes were selected. Captured images of 10 representative swallows and a single swallow in analyzing mode in both high-resolution pressure topography (HRPT) and conventional line tracing formats were provided with calculated metrics. Assessments of esophageal motility disorders showed fair agreement for HRPT and moderate agreement for conventional line tracing (κ = 0.40 and 0.58, respectively). With the HRPT format, the k value was higher in category A (esophagogastric junction [EGJ] relaxation abnormality) than in categories B (major body peristalsis abnormalities with intact EGJ relaxation) and C (minor body peristalsis abnormalities or normal body peristalsis with intact EGJ relaxation). The overall exact diagnostic accuracy for the HRPT format was 58.8% and rater's position was an independent factor for exact diagnostic accuracy. The diagnostic accuracy for major disorders was 63.4% with the HRPT format. The frequency of major discrepancies was higher for category B disorders than for category A disorders (38.4% vs 15.4%; P < 0.001). The interpreter's experience significantly affected the exact diagnostic accuracy of HRM for esophageal motility disorders. The diagnostic accuracy for major disorders was higher for achalasia than distal esophageal spasm and jackhammer esophagus.

  12. DIRECT GEOREFERENCING : A NEW STANDARD IN PHOTOGRAMMETRY FOR HIGH ACCURACY MAPPING

    Directory of Open Access Journals (Sweden)

    A. Rizaldy

    2012-07-01

    Full Text Available Direct georeferencing is a new method in photogrammetry, especially in the digital camera era. Theoretically, this method does not require ground control points (GCP and the Aerial Triangulation (AT, to process aerial photography into ground coordinates. Compared with the old method, this method has three main advantages: faster data processing, simple workflow and less expensive project, at the same accuracy. Direct georeferencing using two devices, GPS and IMU. GPS recording the camera coordinates (X, Y, Z, and IMU recording the camera orientation (omega, phi, kappa. Both parameters merged into Exterior Orientation (EO parameter. This parameters required for next steps in the photogrammetric projects, such as stereocompilation, DSM generation, orthorectification and mosaic. Accuracy of this method was tested on topographic map project in Medan, Indonesia. Large-format digital camera Ultracam X from Vexcel is used, while the GPS / IMU is IGI AeroControl. 19 Independent Check Point (ICP were used to determine the accuracy. Horizontal accuracy is 0.356 meters and vertical accuracy is 0.483 meters. Data with this accuracy can be used for 1:2.500 map scale project.

  13. High-performance mass storage system for workstations

    Science.gov (United States)

    Chiang, T.; Tang, Y.; Gupta, L.; Cooperman, S.

    1993-01-01

    Reduced Instruction Set Computer (RISC) workstations and Personnel Computers (PC) are very popular tools for office automation, command and control, scientific analysis, database management, and many other applications. However, when using Input/Output (I/O) intensive applications, the RISC workstations and PC's are often overburdened with the tasks of collecting, staging, storing, and distributing data. Also, by using standard high-performance peripherals and storage devices, the I/O function can still be a common bottleneck process. Therefore, the high-performance mass storage system, developed by Loral AeroSys' Independent Research and Development (IR&D) engineers, can offload a RISC workstation of I/O related functions and provide high-performance I/O functions and external interfaces. The high-performance mass storage system has the capabilities to ingest high-speed real-time data, perform signal or image processing, and stage, archive, and distribute the data. This mass storage system uses a hierarchical storage structure, thus reducing the total data storage cost, while maintaining high-I/O performance. The high-performance mass storage system is a network of low-cost parallel processors and storage devices. The nodes in the network have special I/O functions such as: SCSI controller, Ethernet controller, gateway controller, RS232 controller, IEEE488 controller, and digital/analog converter. The nodes are interconnected through high-speed direct memory access links to form a network. The topology of the network is easily reconfigurable to maximize system throughput for various applications. This high-performance mass storage system takes advantage of a 'busless' architecture for maximum expandability. The mass storage system consists of magnetic disks, a WORM optical disk jukebox, and an 8mm helical scan tape to form a hierarchical storage structure. Commonly used files are kept in the magnetic disk for fast retrieval. The optical disks are used as archive

  14. Towards Building Reliable, High-Accuracy Solar Irradiance Database For Arid Climates

    Science.gov (United States)

    Munawwar, S.; Ghedira, H.

    2012-12-01

    Middle East's growing interest in renewable energy has led to increased activity in solar technology development with the recent commissioning of several utility-scale solar power projects and many other commercial installations across the Arabian Peninsula. The region, lying in a virtually rainless sunny belt with a typical daily average solar radiation exceeding 6 kWh/m2, is also one of the most promising candidates for solar energy deployment. However, it is not the availability of resource, but its characterization and reasonably accurate assessment that determines the application potential. Solar irradiance, magnitude and variability inclusive, is the key input in assessing the economic feasibility of a solar system. The accuracy of such data is of critical importance for realistic on-site performance estimates. This contribution aims to identify the key stages in developing a robust solar database for desert climate by focusing on the challenges that an arid environment presents to parameterization of solar irradiance attenuating factors. Adjustments are proposed based on the currently available resource assessment tools to produce high quality data for assessing bankability. Establishing and maintaining ground solar irradiance measurements is an expensive affair and fairly limited in time (recently operational) and space (fewer sites) in the Gulf region. Developers within solar technology industry, therefore, rely on solar radiation models and satellite-derived data for prompt resource assessment needs. It is imperative that such estimation tools are as accurate as possible. While purely empirical models have been widely researched and validated in the Arabian Peninsula's solar modeling history, they are known to be intrinsically site-specific. A primal step to modeling is an in-depth understanding of the region's climate, identifying the key players attenuating radiation and their appropriate characterization to determine solar irradiance. Physical approach

  15. An ultra-sensitive instrument for collision activated dissociation mass spectrometry with high mass resolution

    International Nuclear Information System (INIS)

    Louter, G.J.

    1982-01-01

    During the last decade Collision Activated Dissociation Mass Spectrometry (CAD-MS) has developed into an important and sometimes unique technique for the structure elucidation of ions. An extensive description of the double stage MS is given, which has been especially devloped for CAD-MS. A high mass resolution and a very high sensitivity are obtained by application of special techniques like post-acceleration of fragment ions, quadrupole (Q-pole) lenses and an electro-optical, simultaneous ion detection system. The operation of the rather complex ion-optics is demonstrated by application of a computer simulation of the tandem MS. Special attention is given to the action of the four Q-pole lenses and the second sector magnet upon curvature and position of the mass focal plane. Two mass calibration methods are described for the fragment spectra. The so-called polynomial-method applies a fifth-order polynomial approximation of the functional relation between position on the detector and corresponding relative momentum of fragment ions. The second method uses the matrix model of the instrument. The detector consists of two channelplates (CEMA), a fibre optics slab, coated with a phosphor layer, a camera objective and a 1024-channels photodiode-array. A bio-chemical and an organic-chemical application of the instrument are given. As bio-chemical application the peak m/z 59 in the pyrolysis mass spectrum of complete mycobacteria is identified. As an example of organic-chemical application the fragmentation process of 2,3-butadienoic acid has been investigated. (Auth.)

  16. Applications of ambient mass spectrometry in high-throughput screening.

    Science.gov (United States)

    Li, Li-Ping; Feng, Bao-Sheng; Yang, Jian-Wang; Chang, Cui-Lan; Bai, Yu; Liu, Hu-Wei

    2013-06-07

    The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).

  17. The research of digital circuit system for high accuracy CCD of portable Raman spectrometer

    Science.gov (United States)

    Yin, Yu; Cui, Yongsheng; Zhang, Xiuda; Yan, Huimin

    2013-08-01

    The Raman spectrum technology is widely used for it can identify various types of molecular structure and material. The portable Raman spectrometer has become a hot direction of the spectrometer development nowadays for its convenience in handheld operation and real-time detection which is superior to traditional Raman spectrometer with heavy weight and bulky size. But there is still a gap for its measurement sensitivity between portable and traditional devices. However, portable Raman Spectrometer with Shell-Isolated Nanoparticle-Enhanced Raman Spectroscopy (SHINERS) technology can enhance the Raman signal significantly by several orders of magnitude, giving consideration in both measurement sensitivity and mobility. This paper proposed a design and implementation of driver and digital circuit for high accuracy CCD sensor, which is core part of portable spectrometer. The main target of the whole design is to reduce the dark current generation rate and increase signal sensitivity during the long integration time, and in the weak signal environment. In this case, we use back-thinned CCD image sensor from Hamamatsu Corporation with high sensitivity, low noise and large dynamic range. In order to maximize this CCD sensor's performance and minimize the whole size of the device simultaneously to achieve the project indicators, we delicately designed a peripheral circuit for the CCD sensor. The design is mainly composed with multi-voltage circuit, sequential generation circuit, driving circuit and A/D transition parts. As the most important power supply circuit, the multi-voltage circuits with 12 independent voltages are designed with reference power supply IC and set to specified voltage value by the amplifier making up the low-pass filter, which allows the user to obtain a highly stable and accurate voltage with low noise. What's more, to make our design easy to debug, CPLD is selected to generate sequential signal. The A/D converter chip consists of a correlated

  18. In-depth, high-accuracy proteomics of sea urchin tooth organic matrix

    Directory of Open Access Journals (Sweden)

    Mann Matthias

    2008-12-01

    Full Text Available Abstract Background The organic matrix contained in biominerals plays an important role in regulating mineralization and in determining biomineral properties. However, most components of biomineral matrices remain unknown at present. In sea urchin tooth, which is an important model for developmental biology and biomineralization, only few matrix components have been identified. The recent publication of the Strongylocentrotus purpuratus genome sequence rendered possible not only the identification of genes potentially coding for matrix proteins, but also the direct identification of proteins contained in matrices of skeletal elements by in-depth, high-accuracy proteomic analysis. Results We identified 138 proteins in the matrix of tooth powder. Only 56 of these proteins were previously identified in the matrices of test (shell and spine. Among the novel components was an interesting group of five proteins containing alanine- and proline-rich neutral or basic motifs separated by acidic glycine-rich motifs. In addition, four of the five proteins contained either one or two predicted Kazal protease inhibitor domains. The major components of tooth matrix were however largely identical to the set of spicule matrix proteins and MSP130-related proteins identified in test (shell and spine matrix. Comparison of the matrices of crushed teeth to intact teeth revealed a marked dilution of known intracrystalline matrix proteins and a concomitant increase in some intracellular proteins. Conclusion This report presents the most comprehensive list of sea urchin tooth matrix proteins available at present. The complex mixture of proteins identified may reflect many different aspects of the mineralization process. A comparison between intact tooth matrix, presumably containing odontoblast remnants, and crushed tooth matrix served to differentiate between matrix components and possible contributions of cellular remnants. Because LC-MS/MS-based methods directly

  19. Automated, high accuracy classification of Parkinsonian disorders: a pattern recognition approach.

    Directory of Open Access Journals (Sweden)

    Andre F Marquand

    Full Text Available Progressive supranuclear palsy (PSP, multiple system atrophy (MSA and idiopathic Parkinson's disease (IPD can be clinically indistinguishable, especially in the early stages, despite distinct patterns of molecular pathology. Structural neuroimaging holds promise for providing objective biomarkers for discriminating these diseases at the single subject level but all studies to date have reported incomplete separation of disease groups. In this study, we employed multi-class pattern recognition to assess the value of anatomical patterns derived from a widely available structural neuroimaging sequence for automated classification of these disorders. To achieve this, 17 patients with PSP, 14 with IPD and 19 with MSA were scanned using structural MRI along with 19 healthy controls (HCs. An advanced probabilistic pattern recognition approach was employed to evaluate the diagnostic value of several pre-defined anatomical patterns for discriminating the disorders, including: (i a subcortical motor network; (ii each of its component regions and (iii the whole brain. All disease groups could be discriminated simultaneously with high accuracy using the subcortical motor network. The region providing the most accurate predictions overall was the midbrain/brainstem, which discriminated all disease groups from one another and from HCs. The subcortical network also produced more accurate predictions than the whole brain and all of its constituent regions. PSP was accurately predicted from the midbrain/brainstem, cerebellum and all basal ganglia compartments; MSA from the midbrain/brainstem and cerebellum and IPD from the midbrain/brainstem only. This study demonstrates that automated analysis of structural MRI can accurately predict diagnosis in individual patients with Parkinsonian disorders, and identifies distinct patterns of regional atrophy particularly useful for this process.

  20. High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma

    Energy Technology Data Exchange (ETDEWEB)

    Nabavizadeh, S.A.; Assadsangabi, R.; Hajmomenian, M.; Vossough, A. [Perelman School of Medicine of the University of Pennsylvania, Department of Radiology, Children' s Hospital of Philadelphia, Philadelphia, PA (United States); Santi, M. [Perelman School of Medicine of the University of Pennsylvania, Department of Pathology, Children' s Hospital of Philadelphia, Philadelphia, PA (United States)

    2015-05-01

    Pilomyxoid astrocytoma (PMA) is a relatively new tumor entity which has been added to the 2007 WHO Classification of tumors of the central nervous system. The goal of this study is to utilize arterial spin labeling (ASL) perfusion imaging to differentiate PMA from pilocytic astrocytoma (PA). Pulsed ASL and conventional MRI sequences of patients with PMA and PA in the past 5 years were retrospectively evaluated. Patients with history of radiation or treatment with anti-angiogenic drugs were excluded. A total of 24 patients (9 PMA, 15 PA) were included. There were statistically significant differences between PMA and PA in mean tumor/gray matter (GM) cerebral blood flow (CBF) ratios (1.3 vs 0.4, p < 0.001) and maximum tumor/GM CBF ratio (2.3 vs 1, p < 0.001). Area under the receiver operating characteristic (ROC) curves for differentiation of PMA from PA was 0.91 using mean tumor CBF, 0.95 using mean tumor/GM CBF ratios, and 0.89 using maximum tumor/GM CBF. Using a threshold value of 0.91, the mean tumor/GM CBF ratio was able to diagnose PMA with 77 % sensitivity, 100 % specificity, and a threshold value of 0.7, provided 88 % sensitivity and 86 % specificity. There was no statistically significant difference between the two tumors in enhancement pattern (p = 0.33), internal architecture (p = 0.15), or apparent diffusion coefficient (ADC) values (p = 0.07). ASL imaging has high accuracy in differentiating PMA from PA. The result of this study may have important applications in prognostication and treatment planning especially in patients with less accessible tumors such as hypothalamic-chiasmatic gliomas. (orig.)

  1. Functional knowledge transfer for high-accuracy prediction of under-studied biological processes.

    Directory of Open Access Journals (Sweden)

    Christopher Y Park

    Full Text Available A key challenge in genetics is identifying the functional roles of genes in pathways. Numerous functional genomics techniques (e.g. machine learning that predict protein function have been developed to address this question. These methods generally build from existing annotations of genes to pathways and thus are often unable to identify additional genes participating in processes that are not already well studied. Many of these processes are well studied in some organism, but not necessarily in an investigator's organism of interest. Sequence-based search methods (e.g. BLAST have been used to transfer such annotation information between organisms. We demonstrate that functional genomics can complement traditional sequence similarity to improve the transfer of gene annotations between organisms. Our method transfers annotations only when functionally appropriate as determined by genomic data and can be used with any prediction algorithm to combine transferred gene function knowledge with organism-specific high-throughput data to enable accurate function prediction. We show that diverse state-of-art machine learning algorithms leveraging functional knowledge transfer (FKT dramatically improve their accuracy in predicting gene-pathway membership, particularly for processes with little experimental knowledge in an organism. We also show that our method compares favorably to annotation transfer by sequence similarity. Next, we deploy FKT with state-of-the-art SVM classifier to predict novel genes to 11,000 biological processes across six diverse organisms and expand the coverage of accurate function predictions to processes that are often ignored because of a dearth of annotated genes in an organism. Finally, we perform in vivo experimental investigation in Danio rerio and confirm the regulatory role of our top predicted novel gene, wnt5b, in leftward cell migration during heart development. FKT is immediately applicable to many bioinformatics

  2. High Multiplicity Searches at the LHC Using Jet Masses

    Energy Technology Data Exchange (ETDEWEB)

    Hook, Anson; /SLAC /Stanford U., Appl. Phys. Dept.; Izaguirre, Eder; /SLAC /Stanford U., Phys. Dept.; Lisanti, Mariangela; /Princeton U.; Wacker, Jay G.; /SLAC /Stanford U., ITP

    2012-04-24

    This article introduces a new class of searches for physics beyond the Standard Model that improves the sensitivity to signals with high jet multiplicity. The proposed searches gain access to high multiplicity signals by reclustering events into large-radius, or 'fat', jets and by requiring that each event has multiple massive jets. This technique is applied to supersymmetric scenarios in which gluinos are pair-produced and then subsequently decay to final states with either moderate quantities of missing energy or final states without missing energy. In each of these scenarios, the use of jet mass improves the estimated reach in gluino mass by 20% to 50% over current LHC searches.

  3. High accuracy subwavelength distance measurements: A variable-angle standing-wave total-internal-reflection optical microscope

    International Nuclear Information System (INIS)

    Haynie, A.; Min, T.-J.; Luan, L.; Mu, W.; Ketterson, J. B.

    2009-01-01

    We describe an extension of the total-internal-reflection microscopy technique that permits direct in-plane distance measurements with high accuracy (<10 nm) over a wide range of separations. This high position accuracy arises from the creation of a standing evanescent wave and the ability to sweep the nodal positions (intensity minima of the standing wave) in a controlled manner via both the incident angle and the relative phase of the incoming laser beams. Some control over the vertical resolution is available through the ability to scan the incoming angle and with it the evanescent penetration depth.

  4. High temperature mass spectrometry for thermodynamic study of radioactive materials

    International Nuclear Information System (INIS)

    Pattoret, Andre; Philippot, Joseph; Pesme, Olivier.

    1983-01-01

    Thermodynamic properties and evaporation kinetics are essential data to evaluate the nuclear fuel behaviour under accidental conditions. High temperature mass spectrometry appears as a valuable method to set up a such assessment. However, because of size, complexity and radioactivity of the irradiated samples, important improvements of the classical method are required. The device built in CEN/FAR to overcome these problems is described; performances and possible applications out of the nuclear safety field are presented [fr

  5. Investigation of the high mass Drell Yan spectrum with ATLAS

    International Nuclear Information System (INIS)

    Mueller, Thomas A.

    2010-01-01

    The Large Hadron Collider started data taking at the end of 2009 and an integrated luminosity of 1fb -1 is hoped for by the end of 2011. A precise measurement of the high mass Drell Yan spectrum offers a good opportunity for a model independent search for new physics. The muon channel is well suited for this, due to the clean signature and the good muon identification in the Muon Spectrometer. Previous studies at high dimuon masses neglected all background contributions. This study investigated the impact of background on the Drell Yan spectrum and it was found that t anti t decays are the most important contribution. Various selection cuts to suppress those background contributions were studied. A method to take systematic uncertainties into account, whilst optimising these selection cuts, has been developed. It was shown that two additional selection cuts based on b-tagging and Missing Transverse Energy (E T ) will reduce the overall uncertainty for a bin from 200 GeV to 300 GeV from 19.1% to 17.2% for an integrated luminosity of 50 pb -1 . An important aspect of this analysis is to ensure that the efficiency for all selection cuts remains stable at very high dimuon masses of up to 1 TeV. This is not the case for the conventional missing E T , so a derived variable has been introduced and tested. (orig.)

  6. Investigation of the high mass Drell Yan spectrum with ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Thomas A

    2010-09-14

    The Large Hadron Collider started data taking at the end of 2009 and an integrated luminosity of 1fb{sup -1} is hoped for by the end of 2011. A precise measurement of the high mass Drell Yan spectrum offers a good opportunity for a model independent search for new physics. The muon channel is well suited for this, due to the clean signature and the good muon identification in the Muon Spectrometer. Previous studies at high dimuon masses neglected all background contributions. This study investigated the impact of background on the Drell Yan spectrum and it was found that t anti t decays are the most important contribution. Various selection cuts to suppress those background contributions were studied. A method to take systematic uncertainties into account, whilst optimising these selection cuts, has been developed. It was shown that two additional selection cuts based on b-tagging and Missing Transverse Energy (E{sub T}) will reduce the overall uncertainty for a bin from 200 GeV to 300 GeV from 19.1% to 17.2% for an integrated luminosity of 50 pb{sup -1}. An important aspect of this analysis is to ensure that the efficiency for all selection cuts remains stable at very high dimuon masses of up to 1 TeV. This is not the case for the conventional missing E{sub T}, so a derived variable has been introduced and tested. (orig.)

  7. Determination of Selected Polycyclic Aromatic Compounds in Particulate Matter Samples with Low Mass Loading: An Approach to Test Method Accuracy

    Directory of Open Access Journals (Sweden)

    Susana García-Alonso

    2017-01-01

    Full Text Available A miniaturized analytical procedure to determine selected polycyclic aromatic compounds (PACs in low mass loadings (<10 mg of particulate matter (PM is evaluated. The proposed method is based on a simple sonication/agitation method using small amounts of solvent for extraction. The use of a reduced sample size of particulate matter is often limiting for allowing the quantification of analytes. This also leads to the need for changing analytical procedures and evaluating its performance. The trueness and precision of the proposed method were tested using ambient air samples. Analytical results from the proposed method were compared with those of pressurized liquid and microwave extractions. Selected PACs (polycyclic aromatic hydrocarbons (PAHs and nitro polycyclic aromatic hydrocarbons (NPAHs were determined by liquid chromatography with fluorescence detection (HPLC/FD. Taking results from pressurized liquid extractions as reference values, recovery rates of sonication/agitation method were over 80% for the most abundant PAHs. Recovery rates of selected NPAHs were lower. Enhanced rates were obtained when methanol was used as a modifier. Intermediate precision was estimated by data comparison from two mathematical approaches: normalized difference data and pooled relative deviations. Intermediate precision was in the range of 10–20%. The effectiveness of the proposed method was evaluated in PM aerosol samples collected with very low mass loadings (<0.2 mg during characterization studies from turbofan engine exhausts.

  8. Mass Customisation and Highly Individualised Solutions. Stretching Mass Customisation Beyond the Traditional Paradigm of Industrial Production

    DEFF Research Database (Denmark)

    Morelli, Nicola; Nielsen, Louise Møller

    2007-01-01

    and consumption patterns. The reference to a paradigm shift helps emphasising the inherent limits of industrial production and the elements of changes brought about by the possibility to generate highly individualised solutions. The concept of mass customisation was introduced to extend the domain of industrial...... production beyond its original limitations, however it is strongly linked to the paradigm of industrial production and not always usable to support and explain new ways of organising value creation. This paper proposes an analysis of this paradigm shift through three cases, which emphasise some elements...... of mass customisation that are still relevant to the new paradigm. At the same time the paper emphasises the limits of this concept and the need for a new perspective view to interpret the ongoing change in production and consumption systems....

  9. Linking high resolution mass spectrometry data with exposure ...

    Science.gov (United States)

    There is a growing need in the field of exposure science for monitoring methods that rapidly screen environmental media for suspect contaminants. Measurement and analysis platforms, based on high resolution mass spectrometry (HRMS), now exist to meet this need. Here we describe results of a study that links HRMS data with exposure predictions from the U.S. EPA's ExpoCast™ program and in vitro bioassay data from the U.S. interagency Tox21 consortium. Vacuum dust samples were collected from 56 households across the U.S. as part of the American Healthy Homes Survey (AHHS). Sample extracts were analyzed using liquid chromatography time-of-flight mass spectrometry (LC–TOF/MS) with electrospray ionization. On average, approximately 2000 molecular features were identified per sample (based on accurate mass) in negative ion mode, and 3000 in positive ion mode. Exact mass, isotope distribution, and isotope spacing were used to match molecular features with a unique listing of chemical formulas extracted from EPA's Distributed Structure-Searchable Toxicity (DSSTox) database. A total of 978 DSSTox formulas were consistent with the dust LC–TOF/molecular feature data (match score ≥ 90); these formulas mapped to 3228 possible chemicals in the database. Correct assignment of a unique chemical to a given formula required additional validation steps. Each suspect chemical was prioritized for follow-up confirmation using abundance and detection frequency results, along wi

  10. Hydroponic isotope labeling of entire plants and high-performance mass spectrometry for quantitative plant proteomics.

    Science.gov (United States)

    Bindschedler, Laurence V; Mills, Davinia J S; Cramer, Rainer

    2012-01-01

    Hydroponic isotope labeling of entire plants (HILEP) combines hydroponic plant cultivation and metabolic labeling with stable isotopes using (15)N-containing inorganic salts to label whole and mature plants. Employing (15)N salts as the sole nitrogen source for HILEP leads to the production of healthy-looking plants which contain (15)N proteins labeled to nearly 100%. Therefore, HILEP is suitable for quantitative plant proteomic analysis, where plants are grown in either (14)N- or (15)N-hydroponic media and pooled when the biological samples are collected for relative proteome quantitation. The pooled (14)N-/(15)N-protein extracts can be fractionated in any suitable way and digested with a protease for shotgun proteomics, using typically reverse phase liquid chromatography nanoelectrospray ionization tandem mass spectrometry (RPLC-nESI-MS/MS). Best results were obtained with a hybrid ion trap/FT-MS mass spectrometer, combining high mass accuracy and sensitivity for the MS data acquisition with speed and high-throughput MS/MS data acquisition, increasing the number of proteins identified and quantified and improving protein quantitation. Peak processing and picking from raw MS data files, protein identification, and quantitation were performed in a highly automated way using integrated MS data analysis software with minimum manual intervention, thus easing the analytical workflow. In this methodology paper, we describe how to grow Arabidopsis plants hydroponically for isotope labeling using (15)N salts and how to quantitate the resulting proteomes using a convenient workflow that does not require extensive bioinformatics skills.

  11. High-accuracy interferometric measurements of flatness and parallelism of a step gauge

    CSIR Research Space (South Africa)

    Kruger, OA

    2001-01-01

    Full Text Available The most commonly used method in the calibration of step gauges is the coordinate measuring machine (CMM), equipped with a laser interferometer for the highest accuracy. This paper describes a modification to a length-bar measuring machine...

  12. Searches for High-Mass $tt^-$ Resonances at CMS

    CERN Document Server

    Mc Lean, Christine Angela

    2016-01-01

    We present a search for new massive particles decaying to a pair of top quarks with the CMS detector at the LHC. Proton-proton collision data recorded at a centre-of-mass energy of 13 TeV are used. The search is performed by measuring the invariant mass distribution of the top-quark pair and testing for deviations from the expected Standard Model background. Final states with 0 or 1 leptons are considered and the selection optimised accordingly. In the high mass ranges accessible by the LHC at these energies the top quarks are produced with high transverse momentum the products of hadronically decaying top quarks emerge as a single jet, whereas the products of the semileptonic decay mode are characterised by the overlap of the lepton to the b jet. Specific reconstruction algorithm and selections are employed to address the identification of boosted top quark signatures. The results are presented in terms of upper limits on the model cross section. Models of Randall-Sundrum Kaluza-Klein gluon production as wel...

  13. [Accuracy of placenta accreta prenatal diagnosis by ultrasound and MRI in a high-risk population].

    Science.gov (United States)

    Daney de Marcillac, F; Molière, S; Pinton, A; Weingertner, A-S; Fritz, G; Viville, B; Roedlich, M-N; Gaudineau, A; Sananes, N; Favre, R; Nisand, I; Langer, B

    2016-02-01

    Main objective was to compare accuracy of ultrasonography and MRI for antenatal diagnosis of placenta accreta. Secondary objectives were to specify the most common sonographic and RMI signs associated with diagnosis of placenta accreta. This retrospective study used data collected from all potential cases of placenta accreta (patients with an anterior placenta praevia with history of scarred uterus) admitted from 01/2010 to 12/2014 in a level III maternity unit in Strasbourg, France. High-risk patients beneficiated antenatally from ultrasonography and MRI. Sonographic signs registered were: abnormal placental lacunae, increased vascularity on color Doppler, absence of the retroplacental clear space, interrupted bladder line. MRI signs registered were: abnormal uterine bulging, intraplacental bands of low signal intensity on T2-weighted images, increased vascularity, heterogeneous signal of the placenta on T2-weighed, interrupted bladder line, protrusion of the placenta into the cervix. Diagnosis of placenta accreta was confirmed histologically after hysterectomy or clinically in case of successful conservative treatment. Twenty-two potential cases of placenta accreta were referred to our center and underwent both ultrasonography and MRI. All cases of placenta accreta had a placenta praevia associated with history of scarred uterus. Sensibility and specificity for ultrasonography were, respectively, 0.92 and 0.67, for MRI 0.84 and 0.78 without significant difference (p>0.05). The most relevant signs associated with diagnosis of placenta accreta in ultrasonography were increased vascularity on color Doppler (sensibility 0.85/specificity 0.78), abnormal placental lacunae (sensibility 0.92/specificity 0.55) and loss of retroplacental clear space (sensibility 0.76/specificity 1.0). The most relevant signs in MRI were: abnormal uterine bulging (sensitivity 0.92/specificity 0.89), dark intraplacental bands on T2-weighted images (sensitivity 0.83/specificity 0.80) or

  14. Accuracy of High-Resolution MRI with Lumen Distention in Rectal Cancer Staging and Circumferential Margin Involvement Prediction

    International Nuclear Information System (INIS)

    Iannicelli, Elsa; Di Renzo, Sara; Ferri, Mario; Pilozzi, Emanuela; Di Girolamo, Marco; Sapori, Alessandra; Ziparo, Vincenzo; David, Vincenzo

    2014-01-01

    To evaluate the accuracy of magnetic resonance imaging (MRI) with lumen distention for rectal cancer staging and circumferential resection margin (CRM) involvement prediction. Seventy-three patients with primary rectal cancer underwent high-resolution MRI with a phased-array coil performed using 60-80 mL room air rectal distention, 1-3 weeks before surgery. MRI results were compared to postoperative histopathological findings. The overall MRI T staging accuracy was calculated. CRM involvement prediction and the N staging, the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were assessed for each T stage. The agreement between MRI and histological results was assessed using weighted-kappa statistics. The overall MRI accuracy for T staging was 93.6% (k = 0.85). The accuracy, sensitivity, specificity, PPV and NPV for each T stage were as follows: 91.8%, 86.2%, 95.5%, 92.6% and 91.3% for the group ≤ T2; 90.4%, 94.6%, 86.1%, 87.5% and 94% for T3; 98,6%, 85.7%, 100%, 100% and 98.5% for T4, respectively. The predictive CRM accuracy was 94.5% (k = 0.86); the sensitivity, specificity, PPV and NPV were 89.5%, 96.3%, 89.5%, and 96.3% respectively. The N staging accuracy was 68.49% (k = 0.4). MRI performed with rectal lumen distention has proved to be an effective technique both for rectal cancer staging and involved CRM predicting

  15. Accuracy of High-Resolution MRI with Lumen Distention in Rectal Cancer Staging and Circumferential Margin Involvement Prediction

    Energy Technology Data Exchange (ETDEWEB)

    Iannicelli, Elsa; Di Renzo, Sara [Radiology Institute, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Ferri, Mario [Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Pilozzi, Emanuela [Department of Clinical and Molecular Sciences, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Di Girolamo, Marco; Sapori, Alessandra [Radiology Institute, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Ziparo, Vincenzo [Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); David, Vincenzo [Radiology Institute, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy); Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome, Sapienza, Sant' Andrea Hospital, Rome 00189 (Italy)

    2014-07-01

    To evaluate the accuracy of magnetic resonance imaging (MRI) with lumen distention for rectal cancer staging and circumferential resection margin (CRM) involvement prediction. Seventy-three patients with primary rectal cancer underwent high-resolution MRI with a phased-array coil performed using 60-80 mL room air rectal distention, 1-3 weeks before surgery. MRI results were compared to postoperative histopathological findings. The overall MRI T staging accuracy was calculated. CRM involvement prediction and the N staging, the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were assessed for each T stage. The agreement between MRI and histological results was assessed using weighted-kappa statistics. The overall MRI accuracy for T staging was 93.6% (k = 0.85). The accuracy, sensitivity, specificity, PPV and NPV for each T stage were as follows: 91.8%, 86.2%, 95.5%, 92.6% and 91.3% for the group ≤ T2; 90.4%, 94.6%, 86.1%, 87.5% and 94% for T3; 98,6%, 85.7%, 100%, 100% and 98.5% for T4, respectively. The predictive CRM accuracy was 94.5% (k = 0.86); the sensitivity, specificity, PPV and NPV were 89.5%, 96.3%, 89.5%, and 96.3% respectively. The N staging accuracy was 68.49% (k = 0.4). MRI performed with rectal lumen distention has proved to be an effective technique both for rectal cancer staging and involved CRM predicting.

  16. SFOL Pulse: A High Accuracy DME Pulse for Alternative Aircraft Position and Navigation

    Directory of Open Access Journals (Sweden)

    Euiho Kim

    2017-09-01

    Full Text Available In the Federal Aviation Administration’s (FAA performance based navigation strategy announced in 2016, the FAA stated that it would retain and expand the Distance Measuring Equipment (DME infrastructure to ensure resilient aircraft navigation capability during the event of a Global Navigation Satellite System (GNSS outage. However, the main drawback of the DME as a GNSS back up system is that it requires a significant expansion of the current DME ground infrastructure due to its poor distance measuring accuracy over 100 m. The paper introduces a method to improve DME distance measuring accuracy by using a new DME pulse shape. The proposed pulse shape was developed by using Genetic Algorithms and is less susceptible to multipath effects so that the ranging error reduces by 36.0–77.3% when compared to the Gaussian and Smoothed Concave Polygon DME pulses, depending on noise environment.

  17. Automatic J–A Model Parameter Tuning Algorithm for High Accuracy Inrush Current Simulation

    Directory of Open Access Journals (Sweden)

    Xishan Wen

    2017-04-01

    Full Text Available Inrush current simulation plays an important role in many tasks of the power system, such as power transformer protection. However, the accuracy of the inrush current simulation can hardly be ensured. In this paper, a Jiles–Atherton (J–A theory based model is proposed to simulate the inrush current of power transformers. The characteristics of the inrush current curve are analyzed and results show that the entire inrush current curve can be well featured by the crest value of the first two cycles. With comprehensive consideration of both of the features of the inrush current curve and the J–A parameters, an automatic J–A parameter estimation algorithm is proposed. The proposed algorithm can obtain more reasonable J–A parameters, which improve the accuracy of simulation. Experimental results have verified the efficiency of the proposed algorithm.

  18. Coupling nanoliter high-performance liquid chromatography to inductively coupled plasma mass spectrometry for arsenic speciation.

    Science.gov (United States)

    Cheng, Heyong; Shen, Lihuan; Liu, Jinhua; Xu, Zigang; Wang, Yuanchao

    2018-04-01

    Nanoliter high-performance liquid chromatography shows low consumption of solvents and samples, offering one of the best choices for arsenic speciation in precious samples in combination with inuctively coupled plasma mass spectrometry. A systematic investigation on coupling nanoliter high-performance liquid chromatography to inductively coupled plasma mass spectrometry from instrument design to injected sample volume and mobile phase was performed in this study. Nanoflow mobile phase was delivered by flow splitting using a conventional high-pressure pump with reuse of mobile phase waste. Dead volume was minimized to 60 nL for the sheathless interface based on the previously developed nanonebulizer. Capillary columns for nanoliter high-performance liquid chromatography were found to be sensitive to sample loading volume. An apparent difference was also found between the mobile phases for nanoliter and conventional high-performance liquid chromatography. Baseline separation of arsenite, arsenate, monomethylarsenic, and dimethylarsenic was achieved within 11 min on a 15 cm C 18 capillary column and within 12 min on a 25 cm strong anion exchange column. Detection limits of 0.9-1.8 μg/L were obtained with precisions variable in the range of 1.6-4.2%. A good agreement between determined and certified values of a certified reference material of human urine (GBW 09115) validated its accuracy along with good recoveries (87-102%). © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. [Method for evaluating the positional accuracy of a six-degrees-of-freedom radiotherapy couch using high definition digital cameras].

    Science.gov (United States)

    Takemura, Akihiro; Ueda, Shinichi; Noto, Kimiya; Kurata, Yuichi; Shoji, Saori

    2011-01-01

    In this study, we proposed and evaluated a positional accuracy assessment method with two high-resolution digital cameras for add-on six-degrees-of-freedom radiotherapy (6D) couches. Two high resolution digital cameras (D5000, Nikon Co.) were used in this accuracy assessment method. These cameras were placed on two orthogonal axes of a linear accelerator (LINAC) coordinate system and focused on the isocenter of the LINAC. Pictures of a needle that was fixed on the 6D couch were taken by the cameras during couch motions of translation and rotation of each axis. The coordinates of the needle in the pictures were obtained using manual measurement, and the coordinate error of the needle was calculated. The accuracy of a HexaPOD evo (Elekta AB, Sweden) was evaluated using this method. All of the mean values of the X, Y, and Z coordinate errors in the translation tests were within ±0.1 mm. However, the standard deviation of the Z coordinate errors in the Z translation test was 0.24 mm, which is higher than the others. In the X rotation test, we found that the X coordinate of the rotational origin of the 6D couch was shifted. We proposed an accuracy assessment method for a 6D couch. The method was able to evaluate the accuracy of the motion of only the 6D couch and revealed the deviation of the origin of the couch rotation. This accuracy assessment method is effective for evaluating add-on 6D couch positioning.

  20. High-temperature mechanical properties of high-purity 70 mass% Cr-Fe alloy

    Energy Technology Data Exchange (ETDEWEB)

    Asahina, M.; Harima, N.; Takaki, S.; Abiko, K. [Tohoku Univ., Sendai (Japan). Inst. for Materials Research

    2002-01-16

    An ingot of high-purity 70 mass% Cr-Fe alloy was prepared by high-frequency induction melting in a high-purity argon atmosphere using a cold copper crucible. Its tensile properties such as hot-ductility and tensile strength were measured, and compared with the results for a high-purity 50 mass% Cr-Fe alloy, a high-purity 60 mass% Cr-Fe alloy and a Ni-based super-alloy. The formation of {sigma}-phase was also examined. The purity of a 70Cr-Fe alloy (70 mass% Cr-Fe alloy) ingot is more than 99.98 mass% and the total amount of gaseous impurities (C, N, O, S, H) in the 70Cr-Fe alloy is 69.9 mass ppm. The strength of the 70Cr-Fe alloy is higher than those of the 60Cr-Fe alloy and the 50Cr-Fe alloy at the temperatures between 293 and 1573 K, without decrease in ductility with increasing Cr content. The 70Cr-Fe alloy also possesses excellent high-temperature ductility. The {sigma}-phase was not observed after aging of 3.6 Ms at 873 K. Consequently, the 70Cr-Fe alloy is an excellent alloy as the base of super heat-resistant alloys. (orig.)

  1. Thermal Stability of Magnetic Compass Sensor for High Accuracy Positioning Applications

    OpenAIRE

    Van-Tang PHAM; Dinh-Chinh NGUYEN; Quang-Huy TRAN; Duc-Trinh CHU; Duc-Tan TRAN

    2015-01-01

    Using magnetic compass sensors in angle measurements have a wide area of application such as positioning, robot, landslide, etc. However, one of the most phenomenal that affects to the accuracy of the magnetic compass sensor is the temperature. This paper presents two thermal stability schemes for improving performance of a magnetic compass sensor. The first scheme uses the feedforward structure to adjust the angle output of the compass sensor adapt to the variation of the temperature. The se...

  2. A High-Accuracy Linear Conservative Difference Scheme for Rosenau-RLW Equation

    Directory of Open Access Journals (Sweden)

    Jinsong Hu

    2013-01-01

    Full Text Available We study the initial-boundary value problem for Rosenau-RLW equation. We propose a three-level linear finite difference scheme, which has the theoretical accuracy of Oτ2+h4. The scheme simulates two conservative properties of original problem well. The existence, uniqueness of difference solution, and a priori estimates in infinite norm are obtained. Furthermore, we analyze the convergence and stability of the scheme by energy method. At last, numerical experiments demonstrate the theoretical results.

  3. A high precision semi-analytic mass function

    Energy Technology Data Exchange (ETDEWEB)

    Del Popolo, Antonino [Dipartimento di Fisica e Astronomia, University of Catania, Viale Andrea Doria 6, I-95125 Catania (Italy); Pace, Francesco [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL (United Kingdom); Le Delliou, Morgan, E-mail: adelpopolo@oact.inaf.it, E-mail: francesco.pace@manchester.ac.uk, E-mail: delliou@ift.unesp.br [Instituto de Física Teorica, Universidade Estadual de São Paulo (IFT-UNESP), Rua Dr. Bento Teobaldo Ferraz 271, Bloco 2—Barra Funda, 01140-070 São Paulo, SP Brazil (Brazil)

    2017-03-01

    In this paper, extending past works of Del Popolo, we show how a high precision mass function (MF) can be obtained using the excursion set approach and an improved barrier taking implicitly into account a non-zero cosmological constant, the angular momentum acquired by tidal interaction of proto-structures and dynamical friction. In the case of the ΛCDM paradigm, we find that our MF is in agreement at the 3% level to Klypin's Bolshoi simulation, in the mass range M {sub vir} = 5 × 10{sup 9} h {sup −1} M {sub ⊙}–−5 × 10{sup 14} h {sup −1} M {sub ⊙} and redshift range 0 ∼< z ∼< 10. For z = 0 we also compared our MF to several fitting formulae, and found in particular agreement with Bhattacharya's within 3% in the mass range 10{sup 12}–10{sup 16} h {sup −1} M {sub ⊙}. Moreover, we discuss our MF validity for different cosmologies.

  4. Mass

    International Nuclear Information System (INIS)

    Quigg, Chris

    2007-01-01

    In the classical physics we inherited from Isaac Newton, mass does not arise, it simply is. The mass of a classical object is the sum of the masses of its parts. Albert Einstein showed that the mass of a body is a measure of its energy content, inviting us to consider the origins of mass. The protons we accelerate at Fermilab are prime examples of Einsteinian matter: nearly all of their mass arises from stored energy. Missing mass led to the discovery of the noble gases, and a new form of missing mass leads us to the notion of dark matter. Starting with a brief guided tour of the meanings of mass, the colloquium will explore the multiple origins of mass. We will see how far we have come toward understanding mass, and survey the issues that guide our research today.

  5. High body mass index is associated with impaired cognitive control.

    Science.gov (United States)

    Sellaro, Roberta; Colzato, Lorenza S

    2017-06-01

    The prevalence of weight problems is increasing worldwide. There is growing evidence that high body mass index (BMI) is associated with frontal lobe dysfunction and cognitive deficits concerning mental flexibility and inhibitory control efficiency. The present study aims at replicating and extending these observations. We compared cognitive control performance of normal weight (BMI task tapping either inhibitory control (Experiment 1) or interference control (Experiment 2). Experiment 1 replicated previous findings that found less efficient inhibitory control in overweight individuals. Experiment 2 complemented these findings by showing that cognitive control impairments associated with high BMI also extend to the ability to resolve stimulus-induced response conflict and to engage in conflict-driven control adaptation. The present results are consistent with and extend previous literature showing that high BMI in young, otherwise healthy individuals is associated with less efficient cognitive control functioning. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. A high-accuracy optical linear algebra processor for finite element applications

    Science.gov (United States)

    Casasent, D.; Taylor, B. K.

    1984-01-01

    Optical linear processors are computationally efficient computers for solving matrix-matrix and matrix-vector oriented problems. Optical system errors limit their dynamic range to 30-40 dB, which limits their accuray to 9-12 bits. Large problems, such as the finite element problem in structural mechanics (with tens or hundreds of thousands of variables) which can exploit the speed of optical processors, require the 32 bit accuracy obtainable from digital machines. To obtain this required 32 bit accuracy with an optical processor, the data can be digitally encoded, thereby reducing the dynamic range requirements of the optical system (i.e., decreasing the effect of optical errors on the data) while providing increased accuracy. This report describes a new digitally encoded optical linear algebra processor architecture for solving finite element and banded matrix-vector problems. A linear static plate bending case study is described which quantities the processor requirements. Multiplication by digital convolution is explained, and the digitally encoded optical processor architecture is advanced.

  7. High Accuracy Human Activity Recognition Based on Sparse Locality Preserving Projections.

    Science.gov (United States)

    Zhu, Xiangbin; Qiu, Huiling

    2016-01-01

    Human activity recognition(HAR) from the temporal streams of sensory data has been applied to many fields, such as healthcare services, intelligent environments and cyber security. However, the classification accuracy of most existed methods is not enough in some applications, especially for healthcare services. In order to improving accuracy, it is necessary to develop a novel method which will take full account of the intrinsic sequential characteristics for time-series sensory data. Moreover, each human activity may has correlated feature relationship at different levels. Therefore, in this paper, we propose a three-stage continuous hidden Markov model (TSCHMM) approach to recognize human activities. The proposed method contains coarse, fine and accurate classification. The feature reduction is an important step in classification processing. In this paper, sparse locality preserving projections (SpLPP) is exploited to determine the optimal feature subsets for accurate classification of the stationary-activity data. It can extract more discriminative activities features from the sensor data compared with locality preserving projections. Furthermore, all of the gyro-based features are used for accurate classification of the moving data. Compared with other methods, our method uses significantly less number of features, and the over-all accuracy has been obviously improved.

  8. High Accuracy Human Activity Recognition Based on Sparse Locality Preserving Projections.

    Directory of Open Access Journals (Sweden)

    Xiangbin Zhu

    Full Text Available Human activity recognition(HAR from the temporal streams of sensory data has been applied to many fields, such as healthcare services, intelligent environments and cyber security. However, the classification accuracy of most existed methods is not enough in some applications, especially for healthcare services. In order to improving accuracy, it is necessary to develop a novel method which will take full account of the intrinsic sequential characteristics for time-series sensory data. Moreover, each human activity may has correlated feature relationship at different levels. Therefore, in this paper, we propose a three-stage continuous hidden Markov model (TSCHMM approach to recognize human activities. The proposed method contains coarse, fine and accurate classification. The feature reduction is an important step in classification processing. In this paper, sparse locality preserving projections (SpLPP is exploited to determine the optimal feature subsets for accurate classification of the stationary-activity data. It can extract more discriminative activities features from the sensor data compared with locality preserving projections. Furthermore, all of the gyro-based features are used for accurate classification of the moving data. Compared with other methods, our method uses significantly less number of features, and the over-all accuracy has been obviously improved.

  9. High accuracy microwave frequency measurement based on single-drive dual-parallel Mach-Zehnder modulator

    DEFF Research Database (Denmark)

    Zhao, Ying; Pang, Xiaodan; Deng, Lei

    2011-01-01

    A novel approach for broadband microwave frequency measurement by employing a single-drive dual-parallel Mach-Zehnder modulator is proposed and experimentally demonstrated. Based on bias manipulations of the modulator, conventional frequency-to-power mapping technique is developed by performing a...... 10−3 relative error. This high accuracy frequency measurement technique is a promising candidate for high-speed electronic warfare and defense applications....

  10. Diesel characterization by high-resolution mass spectrometry - gas chromatography

    International Nuclear Information System (INIS)

    Baldrich, C.A

    1998-01-01

    High-resolution mass spectrometry-gas chromatography is combined with the HC22 method in order to obtain detailed information about the chemical composition of diesel and the distribution of different compound types in terms of its final boiling temperature from a single analysis. The total time elapsed from sample injection and signal processing to obtain final results is 90 minutes. This fact makes this methodology a new and very important tool for the decision making process concerning the most suitable final boiling temperature and the type of treatment of the product in order to obtain diesel that fulfills the international standards. The consistency and repeatability of the experimental results are demonstrated

  11. Research on high-performance mass storage system

    International Nuclear Information System (INIS)

    Cheng Yaodong; Wang Lu; Huang Qiulan; Zheng Wei

    2010-01-01

    With the enlargement of scientific experiments, more and more data will be produced, which brings great challenge to storage system. Large storage capacity and high data access performance are both important to Mass storage system. This paper firstly reviews some kinds of popular storage systems including network storage system, SAN-based sharing system, WAN File system, object-based parallel file system, hierarchical storage system and cloud storage systems. Then some key technologies are presented. Finally, this paper takes BES storage system as an example and introduces its requirements, architecture and operation results. (authors)

  12. Mass impregnation plant speeds high voltage cable production

    Energy Technology Data Exchange (ETDEWEB)

    1965-05-07

    A mass impregnation and continuous sheath extrusion plant that will eliminate the long period of vacuum treatment usually required for high voltage oil-filled cables is among the latest techniques included in the new factory at Pirelli General's Eastleigh works. The new factory is said to be the first in Europe designed solely for the manufacture of the full range of oil-filled cables. Possible future increases of system voltages to about 750-kV ac or 1000-kV dc have been taken into account in the design of the works, so that only a small amount of modification and new plant will be involved.

  13. A new, high-resolution global mass coral bleaching database.

    Directory of Open Access Journals (Sweden)

    Simon D Donner

    Full Text Available Episodes of mass coral bleaching have been reported in recent decades and have raised concerns about the future of coral reefs on a warming planet. Despite the efforts to enhance and coordinate coral reef monitoring within and across countries, our knowledge of the geographic extent of mass coral bleaching over the past few decades is incomplete. Existing databases, like ReefBase, are limited by the voluntary nature of contributions, geographical biases in data collection, and the variations in the spatial scale of bleaching reports. In this study, we have developed the first-ever gridded, global-scale historical coral bleaching database. First, we conducted a targeted search for bleaching reports not included in ReefBase by personally contacting scientists and divers conducting monitoring in under-reported locations and by extracting data from the literature. This search increased the number of observed bleaching reports by 79%, from 4146 to 7429. Second, we employed spatial interpolation techniques to develop annual 0.04° × 0.04° latitude-longitude global maps of the probability that bleaching occurred for 1985 through 2010. Initial results indicate that the area of coral reefs with a more likely than not (>50% or likely (>66% probability of bleaching was eight times higher in the second half of the assessed time period, after the 1997/1998 El Niño. The results also indicate that annual maximum Degree Heating Weeks, a measure of thermal stress, for coral reefs with a high probability of bleaching increased over time. The database will help the scientific community more accurately assess the change in the frequency of mass coral bleaching events, validate methods of predicting mass coral bleaching, and test whether coral reefs are adjusting to rising ocean temperatures.

  14. A new, high-resolution global mass coral bleaching database.

    Science.gov (United States)

    Donner, Simon D; Rickbeil, Gregory J M; Heron, Scott F

    2017-01-01

    Episodes of mass coral bleaching have been reported in recent decades and have raised concerns about the future of coral reefs on a warming planet. Despite the efforts to enhance and coordinate coral reef monitoring within and across countries, our knowledge of the geographic extent of mass coral bleaching over the past few decades is incomplete. Existing databases, like ReefBase, are limited by the voluntary nature of contributions, geographical biases in data collection, and the variations in the spatial scale of bleaching reports. In this study, we have developed the first-ever gridded, global-scale historical coral bleaching database. First, we conducted a targeted search for bleaching reports not included in ReefBase by personally contacting scientists and divers conducting monitoring in under-reported locations and by extracting data from the literature. This search increased the number of observed bleaching reports by 79%, from 4146 to 7429. Second, we employed spatial interpolation techniques to develop annual 0.04° × 0.04° latitude-longitude global maps of the probability that bleaching occurred for 1985 through 2010. Initial results indicate that the area of coral reefs with a more likely than not (>50%) or likely (>66%) probability of bleaching was eight times higher in the second half of the assessed time period, after the 1997/1998 El Niño. The results also indicate that annual maximum Degree Heating Weeks, a measure of thermal stress, for coral reefs with a high probability of bleaching increased over time. The database will help the scientific community more accurately assess the change in the frequency of mass coral bleaching events, validate methods of predicting mass coral bleaching, and test whether coral reefs are adjusting to rising ocean temperatures.

  15. THE EFFECT OF MODERATE AND HIGH-INTENSITY FATIGUE ON GROUNDSTROKE ACCURACY IN EXPERT AND NON-EXPERT TENNIS PLAYERS

    Directory of Open Access Journals (Sweden)

    Mark Lyons

    2013-06-01

    Full Text Available Exploring the effects of fatigue on skilled performance in tennis presents a significant challenge to the researcher with respect to ecological validity. This study examined the effects of moderate and high-intensity fatigue on groundstroke accuracy in expert and non-expert tennis players. The research also explored whether the effects of fatigue are the same regardless of gender and player's achievement motivation characteristics. 13 expert (7 male, 6 female and 17 non-expert (13 male, 4 female tennis players participated in the study. Groundstroke accuracy was assessed using the modified Loughborough Tennis Skills Test. Fatigue was induced using the Loughborough Intermittent Tennis Test with moderate (70% and high-intensities (90% set as a percentage of peak heart rate (attained during a tennis-specific maximal hitting sprint test. Ratings of perceived exertion were used as an adjunct to the monitoring of heart rate. Achievement goal indicators for each player were assessed using the 2 x 2 Achievement Goals Questionnaire for Sport in an effort to examine if this personality characteristic provides insight into how players perform under moderate and high-intensity fatigue conditions. A series of mixed ANOVA's revealed significant fatigue effects on groundstroke accuracy regardless of expertise. The expert players however, maintained better groundstroke accuracy across all conditions compared to the novice players. Nevertheless, in both groups, performance following high-intensity fatigue deteriorated compared to performance at rest and performance while moderately fatigued. Groundstroke accuracy under moderate levels of fatigue was equivalent to that at rest. Fatigue effects were also similar regardless of gender. No fatigue by expertise, or fatigue by gender interactions were found. Fatigue effects were also equivalent regardless of player's achievement goal indicators. Future research is required to explore the effects of fatigue on

  16. High accuracy prediction of beta-turns and their types using propensities and multiple alignments.

    Science.gov (United States)

    Fuchs, Patrick F J; Alix, Alain J P

    2005-06-01

    We have developed a method that predicts both the presence and the type of beta-turns, using a straightforward approach based on propensities and multiple alignments. The propensities were calculated classically, but the way to use them for prediction was completely new: starting from a tetrapeptide sequence on which one wants to evaluate the presence of a beta-turn, the propensity for a given residue is modified by taking into account all the residues present in the multiple alignment at this position. The evaluation of a score is then done by weighting these propensities by the use of Position-specific score matrices generated by PSI-BLAST. The introduction of secondary structure information predicted by PSIPRED or SSPRO2 as well as taking into account the flanking residues around the tetrapeptide improved the accuracy greatly. This latter evaluated on a database of 426 reference proteins (previously used on other studies) by a sevenfold crossvalidation gave very good results with a Matthews Correlation Coefficient (MCC) of 0.42 and an overall prediction accuracy of 74.8%; this places our method among the best ones. A jackknife test was also done, which gave results within the same range. This shows that it is possible to reach neural networks accuracy with considerably less computional cost and complexity. Furthermore, propensities remain excellent descriptors of amino acid tendencies to belong to beta-turns, which can be useful for peptide or protein engineering and design. For beta-turn type prediction, we reached the best accuracy ever published in terms of MCC (except for the irregular type IV) in the range of 0.25-0.30 for types I, II, and I' and 0.13-0.15 for types VIII, II', and IV. To our knowledge, our method is the only one available on the Web that predicts types I' and II'. The accuracy evaluated on two larger databases of 547 and 823 proteins was not improved significantly. All of this was implemented into a Web server called COUDES (French acronym

  17. Star formation and mass assembly in high redshift galaxies

    Science.gov (United States)

    Santini, P.; Fontana, A.; Grazian, A.; Salimbeni, S.; Fiore, F.; Fontanot, F.; Boutsia, K.; Castellano, M.; Cristiani, S.; de Santis, C.; Gallozzi, S.; Giallongo, E.; Menci, N.; Nonino, M.; Paris, D.; Pentericci, L.; Vanzella, E.

    2009-09-01

    Aims: The goal of this work is to infer the star formation properties and the mass assembly process of high redshift (0.3 ≤ z MUSIC catalog, which has multiwavelength coverage from 0.3 to 24 μm and either spectroscopic or accurate photometric redshifts. We describe how the catalog has been extended by the addition of mid-IR fluxes derived from the MIPS 24 μm image. We compared two different estimators of the star formation rate (SFR hereafter). One is the total infrared emission derived from 24 μm, estimated using both synthetic and empirical IR templates. The other one is a multiwavelength fit to the full galaxy SED, which automatically accounts for dust reddening and age-star formation activity degeneracies. For both estimates, we computed the SFR density and the specific SFR. Results: We show that the two SFR indicators are roughly consistent, once the uncertainties involved are taken into account. However, they show a systematic trend, IR-based estimates exceeding the fit-based ones as the star formation rate increases. With this new catalog, we show that: a) at z>0.3, the star formation rate is correlated well with stellar mass, and this relationship seems to steepen with redshift if one relies on IR-based estimates of the SFR; b) the contribution to the global SFRD by massive galaxies increases with redshift up to ≃ 2.5, more rapidly than for galaxies of lower mass, but appears to flatten at higher z; c) despite this increase, the most important contributors to the SFRD at any z are galaxies of about, or immediately lower than, the characteristic stellar mass; d) at z≃ 2, massive galaxies are actively star-forming, with a median {SFR} ≃ 300 M_⊙ yr-1. During this epoch, our targeted galaxies assemble a substantial part of their final stellar mass; e) the specific SFR (SSFR) shows a clear bimodal distribution. Conclusions: The analysis of the SFR density and the SSFR seems to support the downsizing scenario, according to which high mass galaxies

  18. Accuracy of applicator tip reconstruction in MRI-guided interstitial 192Ir-high-dose-rate brachytherapy of liver tumors

    International Nuclear Information System (INIS)

    Wybranski, Christian; Eberhardt, Benjamin; Fischbach, Katharina; Fischbach, Frank; Walke, Mathias; Hass, Peter; Röhl, Friedrich-Wilhelm; Kosiek, Ortrud; Kaiser, Mandy; Pech, Maciej; Lüdemann, Lutz; Ricke, Jens

    2015-01-01

    Background and purpose: To evaluate the reconstruction accuracy of brachytherapy (BT) applicators tips in vitro and in vivo in MRI-guided 192 Ir-high-dose-rate (HDR)-BT of inoperable liver tumors. Materials and methods: Reconstruction accuracy of plastic BT applicators, visualized by nitinol inserts, was assessed in MRI phantom measurements and in MRI 192 Ir-HDR-BT treatment planning datasets of 45 patients employing CT co-registration and vector decomposition. Conspicuity, short-term dislocation, and reconstruction errors were assessed in the clinical data. The clinical effect of applicator reconstruction accuracy was determined in follow-up MRI data. Results: Applicator reconstruction accuracy was 1.6 ± 0.5 mm in the phantom measurements. In the clinical MRI datasets applicator conspicuity was rated good/optimal in ⩾72% of cases. 16/129 applicators showed not time dependent deviation in between MRI/CT acquisition (p > 0.1). Reconstruction accuracy was 5.5 ± 2.8 mm, and the average image co-registration error was 3.1 ± 0.9 mm. Vector decomposition revealed no preferred direction of reconstruction errors. In the follow-up data deviation of planned dose distribution and irradiation effect was 6.9 ± 3.3 mm matching the mean co-registration error (6.5 ± 2.5 mm; p > 0.1). Conclusion: Applicator reconstruction accuracy in vitro conforms to AAPM TG 56 standard. Nitinol-inserts are feasible for applicator visualization and yield good conspicuity in MRI treatment planning data. No preferred direction of reconstruction errors were found in vivo

  19. Horizontal Positional Accuracy of Google Earth’s High-Resolution Imagery Archive

    Directory of Open Access Journals (Sweden)

    David Potere

    2008-12-01

    Full Text Available Google Earth now hosts high-resolution imagery that spans twenty percent of the Earth’s landmass and more than a third of the human population. This contemporary highresolution archive represents a significant, rapidly expanding, cost-free and largely unexploited resource for scientific inquiry. To increase the scientific utility of this archive, we address horizontal positional accuracy (georegistration by comparing Google Earth with Landsat GeoCover scenes over a global sample of 436 control points located in 109 cities worldwide. Landsat GeoCover is an orthorectified product with known absolute positional accuracy of less than 50 meters root-mean-squared error (RMSE. Relative to Landsat GeoCover, the 436 Google Earth control points have a positional accuracy of 39.7 meters RMSE (error magnitudes range from 0.4 to 171.6 meters. The control points derived from satellite imagery have an accuracy of 22.8 meters RMSE, which is significantly more accurate than the 48 control-points based on aerial photography (41.3 meters RMSE; t-test p-value < 0.01. The accuracy of control points in more-developed countries is 24.1 meters RMSE, which is significantly more accurate than the control points in developing countries (44.4 meters RMSE; t-test p-value < 0.01. These findings indicate that Google Earth highresolution imagery has a horizontal positional accuracy that is sufficient for assessing moderate-resolution remote sensing products across most of the world’s peri-urban areas.

  20. Investigation of the High Mass Drell Yan Spectrum with ATLAS

    CERN Document Server

    Müller, Thomas

    The Large Hadron Collider started data taking at the end of 009 and an integrated luminosity of 1 fb^-1 is hoped for by the end of 2011. A precise measurement of the high mass Drell Yan spectrum offers a good opportunity for a model independent search for new physics. The muon channel is well suited for this, due to the clean signature and the good muon identification in the Muon Spectrometer. Previous studies at high dimuon masses neglected all background contributions. This study investigated the impact of background on the Drell Yan spectrum and it was found that top antitop decays are the most important contribution. Various selection cuts to suppress those background contributions were studied. A method to take systematic uncertainties into account, whilst optimising these selection cuts, has been developed. It was shown that two additional selection cuts based on b-tagging and Missing Transverse Energy (MET) will reduce the overall uncertainty for a bin from 200 GeV to 300 GeV from 19.1% to 17.2% for an...

  1. A homemade high-resolution orthogonal-injection time-of-flight mass spectrometer with a heated capillary inlet

    International Nuclear Information System (INIS)

    Guo Changjuan; Huang Zhengxu; Gao Wei; Nian Huiqing; Chen Huayong; Dong Junguo; Shen Guoying; Fu Jiamo; Zhou Zhen

    2008-01-01

    We describe a homemade high-resolution orthogonal-injection time-of-flight (O-TOF) mass spectrometer combing a heated capillary inlet. The O-TOF uses a heated capillary tube combined with a radio-frequency only quadrupole (rf-only quadrupole) as an interface to help the ion transmission from the atmospheric pressure to the low-pressure regions. The principle, configuration of the O-TOF, and the performance of the instrument are introduced in this paper. With electrospray ion source, the performances of the mass resolution, the sensitivity, the mass range, and the mass accuracy are described. We also include our results obtained by coupling atmospheric pressure matrix-assisted laser deporption ionization with this instrument

  2. High accuracy mapping with cartographic assessment for a fixed-wing remotely piloted aircraft system

    Science.gov (United States)

    Alves Júnior, Leomar Rufino; Ferreira, Manuel Eduardo; Côrtes, João Batista Ramos; de Castro Jorge, Lúcio André

    2018-01-01

    The lack of updated maps on large scale representations has encouraged the use of remotely piloted aircraft systems (RPAS) to generate maps for a wide range of professionals. However, some questions arise: do the orthomosaics generated by these systems have the cartographic precision required to use them? Which problems can be identified in stitching orthophotos to generate orthomosaics? To answer these questions, an aerophotogrammetric survey was conducted in an environmental conservation unit in the city of Goiânia. The flight plan was set up using the E-motion software, provided by Sensefly-a Swiss manufacturer of the RPAS Swinglet CAM used in this work. The camera installed in the RPAS was the Canon IXUS 220 HS, with the number of pixels in the sensor array of 12.1 megapixel, complementary metal oxide semiconductor 1 ∶ 2.3 ? (4000 × 3000 pixel), horizontal and vertical pixel sizes of 1.54 μm. Using the orthophotos, four orthomosaics were generated in the Pix4D mapper software. The first orthomosaic was generated without using the control points. The other three mosaics were generated using 4, 8, and 16 premarked ground control points. To check the precision and accuracy of the orthomosaics, 46 premarked targets were uniformly distributed in the block. The three-dimensional (3-D) coordinates of the premarked targets were read on the orthomosaic and compared with the coordinates obtained by the geodetic survey real-time kinematic positioning method using the global navigation satellite system receiver signals. The cartographic accuracy standard was evaluated by discrepancies between these coordinates. The bias was analyzed by the Student's t test and the accuracy by the chi-square probability considering the orthomosaic on a scale of 1 ∶ 250, in which 90% of the points tested must have a planimetric error of control points the scale was 10-fold smaller (1 ∶ 3000).

  3. High-accuracy resolver-to-digital conversion via phase locked loop based on PID controller

    Science.gov (United States)

    Li, Yaoling; Wu, Zhong

    2018-03-01

    The problem of resolver-to-digital conversion (RDC) is transformed into the problem of angle tracking control, and a phase locked loop (PLL) method based on PID controller is proposed in this paper. This controller comprises a typical PI controller plus an incomplete differential which can avoid the amplification of higher-frequency noise components by filtering the phase detection error with a low-pass filter. Compared with conventional ones, the proposed PLL method makes the converter a system of type III and thus the conversion accuracy can be improved. Experimental results demonstrate the effectiveness of the proposed method.

  4. KLEIN: Coulomb functions for real lambda and positive energy to high accuracy

    International Nuclear Information System (INIS)

    Barnett, A.R.

    1981-01-01

    KLEIN computes relativistic Schroedinger (Klein-Gordon) equation solutions, i.e. Coulomb functions for real lambda > - 1, Fsub(lambda)(eta,x), Gsub(lambda)(eta,x), F'sub(lambda)(eta,x) and G'sub(lambda)(eta,x) for real kappa > 0 and real eta, - 10 4 4 . Hence it is also suitable for Bessel and spherical Bessel functions. Accuracies are in the range 10 -14 -10 -16 in oscillating region, and approx. equal to 10 -30 on an extended precision compiler. The program is suitable for generating Klein-Gordon wavefunctions for matching in pion and kaon physics. (orig.)

  5. Depth extraction method with high accuracy in integral imaging based on moving array lenslet technique

    Science.gov (United States)

    Wang, Yao-yao; Zhang, Juan; Zhao, Xue-wei; Song, Li-pei; Zhang, Bo; Zhao, Xing

    2018-03-01

    In order to improve depth extraction accuracy, a method using moving array lenslet technique (MALT) in pickup stage is proposed, which can decrease the depth interval caused by pixelation. In this method, the lenslet array is moved along the horizontal and vertical directions simultaneously for N times in a pitch to get N sets of elemental images. Computational integral imaging reconstruction method for MALT is taken to obtain the slice images of the 3D scene, and the sum modulus (SMD) blur metric is taken on these slice images to achieve the depth information of the 3D scene. Simulation and optical experiments are carried out to verify the feasibility of this method.

  6. High Precision Atomic Mass Measurements: Tests of CVC and IMME

    International Nuclear Information System (INIS)

    Eronen, Tommi

    2011-01-01

    Atomic mass is one of the key ingredients in testing the Conserved Vector Current (CVC) hypothesis and Isobaric Mass Multiplet Equation (IMME). With JYFLTRAP Penning trap installation at the University of Jyvaeskylae, Finland, several atomic massses related to these studies have been measured. The performed atomic mass measurements for CVC tests cover almost all the nuclei that are relevant for these studies. To test IMME, masses in two isobaric mass chains (A = 23 and A = 32) have been determined.

  7. High Precision Atomic Mass Measurements: Tests of CVC and IMME

    Energy Technology Data Exchange (ETDEWEB)

    Eronen, Tommi [Department of Physics, University of Jyvaeskylae, FI-40014 University of Jyvaeskylae (Finland); Collaboration: JYFLTRAP Collaboration

    2011-11-30

    Atomic mass is one of the key ingredients in testing the Conserved Vector Current (CVC) hypothesis and Isobaric Mass Multiplet Equation (IMME). With JYFLTRAP Penning trap installation at the University of Jyvaeskylae, Finland, several atomic massses related to these studies have been measured. The performed atomic mass measurements for CVC tests cover almost all the nuclei that are relevant for these studies. To test IMME, masses in two isobaric mass chains (A = 23 and A = 32) have been determined.

  8. Utilization of high-accuracy FTICR-MS data in protein quantitation experiments

    Czech Academy of Sciences Publication Activity Database

    Strohalm, Martin; Novák, Petr; Pompach, Petr; Man, Petr; Kavan, Daniel; Witt, M.; Džubák, P.; Hajdúch, M.; Havlíček, Vladimír

    2009-01-01

    Roč. 44, č. 11 (2009), s. 1565-1570 ISSN 1076-5174 R&D Projects: GA MŠk LC07017 Institutional research plan: CEZ:AV0Z50200510 Keywords : mass spectrometry * protein quantitation * workflow Subject RIV: EE - Microbiology, Virology Impact factor: 3.411, year: 2009

  9. Cause and Cure - Deterioration in Accuracy of CFD Simulations With Use of High-Aspect-Ratio Triangular Tetrahedral Grids

    Science.gov (United States)

    Chang, Sin-Chung; Chang, Chau-Lyan; Venkatachari, Balaji Shankar

    2017-01-01

    Traditionally high-aspect ratio triangular/tetrahedral meshes are avoided by CFD re-searchers in the vicinity of a solid wall, as it is known to reduce the accuracy of gradient computations in those regions and also cause numerical instability. Although for certain complex geometries, the use of high-aspect ratio triangular/tetrahedral elements in the vicinity of a solid wall can be replaced by quadrilateral/prismatic elements, ability to use triangular/tetrahedral elements in such regions without any degradation in accuracy can be beneficial from a mesh generation point of view. The benefits also carry over to numerical frameworks such as the space-time conservation element and solution element (CESE), where triangular/tetrahedral elements are the mandatory building blocks. With the requirement of the CESE method in mind, a rigorous mathematical framework that clearly identities the reason behind the difficulties in use of such high-aspect ratio triangular/tetrahedral elements is presented here. As will be shown, it turns out that the degree of accuracy deterioration of gradient computation involving a triangular element is hinged on the value of its shape factor Gamma def = sq sin Alpha1 + sq sin Alpha2 + sq sin Alpha3, where Alpha1; Alpha2 and Alpha3 are the internal angles of the element. In fact, it is shown that the degree of accuracy deterioration increases monotonically as the value of Gamma decreases monotonically from its maximal value 9/4 (attained by an equilateral triangle only) to a value much less than 1 (associated with a highly obtuse triangle). By taking advantage of the fact that a high-aspect ratio triangle is not necessarily highly obtuse, and in fact it can have a shape factor whose value is close to the maximal value 9/4, a potential solution to avoid accuracy deterioration of gradient computation associated with a high-aspect ratio triangular grid is given. Also a brief discussion on the extension of the current mathematical framework to the

  10. Affine-Invariant Geometric Constraints-Based High Accuracy Simultaneous Localization and Mapping

    Directory of Open Access Journals (Sweden)

    Gangchen Hua

    2017-01-01

    Full Text Available In this study we describe a new appearance-based loop-closure detection method for online incremental simultaneous localization and mapping (SLAM using affine-invariant-based geometric constraints. Unlike other pure bag-of-words-based approaches, our proposed method uses geometric constraints as a supplement to improve accuracy. By establishing an affine-invariant hypothesis, the proposed method excludes incorrect visual words and calculates the dispersion of correctly matched visual words to improve the accuracy of the likelihood calculation. In addition, camera’s intrinsic parameters and distortion coefficients are adequate for this method. 3D measuring is not necessary. We use the mechanism of Long-Term Memory and Working Memory (WM to manage the memory. Only a limited size of the WM is used for loop-closure detection; therefore the proposed method is suitable for large-scale real-time SLAM. We tested our method using the CityCenter and Lip6Indoor datasets. Our proposed method results can effectively correct the typical false-positive localization of previous methods, thus gaining better recall ratios and better precision.

  11. The use of high accuracy NAA for the certification of NIST Standard Reference Materials

    International Nuclear Information System (INIS)

    Becker, D.A.; Greenberg, R.R.; Stone, S.

    1991-01-01

    Neutron activation analysis (NAA) is only one of many analytical techniques used at the National Institute of Standards and Technology (NIST) for the certification of NIST Standard Reference Materials (SRMs). We compete daily against all of the other available analytical techniques in terms of accuracy, precision, and the cost required to obtain that requisite accuracy and precision. Over the years, the authors have found that NAA can and does compete favorably with these other techniques because of its' unique capabilities for redundancy and quality assurance. Good examples are the two new NIST leaf SRMs, Apple Leaves (SRM 1515) and Peach Leaves (SRM 1547). INAA was used to measure the homogeneity of 12 elements in 15 samples of each material at the 100 mg sample size. In addition, instrumental and radiochemical NAA combined for 27 elemental determinations, out of a total of 54 elemental determinations made on each material with all NIST techniques combined. This paper describes the NIST NAA procedures used in these analyses, the quality assurance techniques employed, and the analytical results for the 24 elements determined by NAA in these new botanical SRMs. The NAA results are also compared to the final certified values for these SRMs

  12. High-accuracy 3-D modeling of cultural heritage: the digitizing of Donatello's "Maddalena".

    Science.gov (United States)

    Guidi, Gabriele; Beraldin, J Angelo; Atzeni, Carlo

    2004-03-01

    Three-dimensional digital modeling of Heritage works of art through optical scanners, has been demonstrated in recent years with results of exceptional interest. However, the routine application of three-dimensional (3-D) modeling to Heritage conservation still requires the systematic investigation of a number of technical problems. In this paper, the acquisition process of the 3-D digital model of the Maddalena by Donatello, a wooden statue representing one of the major masterpieces of the Italian Renaissance which was swept away by the Florence flood of 1966 and successively restored, is described. The paper reports all the steps of the acquisition procedure, from the project planning to the solution of the various problems due to range camera calibration and to material non optically cooperative. Since the scientific focus is centered on the 3-D model overall dimensional accuracy, a methodology for its quality control is described. Such control has demonstrated how, in some situations, the ICP-based alignment can lead to incorrect results. To circumvent this difficulty we propose an alignment technique based on the fusion of ICP with close-range digital photogrammetry and a non-invasive procedure in order to generate a final accurate model. In the end detailed results are presented, demonstrating the improvement of the final model, and how the proposed sensor fusion ensure a pre-specified level of accuracy.

  13. Vision-based algorithms for high-accuracy measurements in an industrial bakery

    Science.gov (United States)

    Heleno, Paulo; Davies, Roger; Correia, Bento A. B.; Dinis, Joao

    2002-02-01

    This paper describes the machine vision algorithms developed for VIP3D, a measuring system used in an industrial bakery to monitor the dimensions and weight of loaves of bread (baguettes). The length and perimeter of more than 70 different varieties of baguette are measured with 1-mm accuracy, quickly, reliably and automatically. VIP3D uses a laser triangulation technique to measure the perimeter. The shape of the loaves is approximately cylindrical and the perimeter is defined as the convex hull of a cross-section perpendicular to the baguette axis at mid-length. A camera, mounted obliquely to the measuring plane, captures an image of a laser line projected onto the upper surface of the baguette. Three cameras are used to measure the baguette length, a solution adopted in order to minimize perspective-induced measurement errors. The paper describes in detail the machine vision algorithms developed to perform segmentation of the laser line and subsequent calculation of the perimeter of the baguette. The algorithms used to segment and measure the position of the ends of the baguette, to sub-pixel accuracy, are also described, as are the algorithms used to calibrate the measuring system and compensate for camera-induced image distortion.

  14. Maser Emission Associated with Young High Mass Stars

    Science.gov (United States)

    Mahmoud, Khaled Abdalla Edris

    In this work the maser emission has been used to study the very early stage evolution of the young stars. The maser emission of OH molecule was searched for towards a sample of high mass protostellar objects using the Nançay and GBT telescopes. The sample of objects searched was selected to contain very young forming high mass stars. The results of this survey have been compared with previous H2O and CH3OH masers observations. Then MERLIN has been used to map the OH as well as H2O and CH3OH masers towards one of these sources in high angular resolution. The survey detected OH maser emission towards 63 objects with 37 new detections. There are 56 star forming regions and 7 OH/IR candidates. The detection of OH masers towards 26% of a sample of 217 sources should remove any doubt about the existence of OH maser emission towards these objects of this early evolutionary stage. Nearly half of the detected sources have OH fluxes rates and velocity range support the spatial association of OH and class II CH3OH masers as suggested by Caswell et al. [1995] and modelled by Cragg et al. [2002]. IRAS20126+4104 was mapped in the OH, water and methanol masers using MERLIN. The 1665-MHz OH, 22-GHz H2O and 6.7-GHz CH3OH masers are detected and all originate very close to the central source. The OH and methanol masers appear to trace part of the circumstellar disk around the central source. The positions and velocities of the OH masers are consistent with Keplerian rotation around a central mass of ˜5Msun. The water masers are offset from the OH and CH3OH masers and have significantly changed since they were last observed, but still appear to be associated outflow from the source. All the OH masers components are circular polarized, in some cases reaching 100 percent while some OH components also have low levels of linear polarization. We identified one Zeeman pair and the splitting of this pair indicate the presence of a magnetic field of strength ˜11 mG within ˜0.5" (850 AU

  15. Interobserver Variability and Accuracy of High-Definition Endoscopic Diagnosis for Gastric Intestinal Metaplasia among Experienced and Inexperienced Endoscopists

    Science.gov (United States)

    Hyun, Yil Sik; Bae, Joong Ho; Park, Hye Sun; Eun, Chang Soo

    2013-01-01

    Accurate diagnosis of gastric intestinal metaplasia is important; however, conventional endoscopy is known to be an unreliable modality for diagnosing gastric intestinal metaplasia (IM). The aims of the study were to evaluate the interobserver variation in diagnosing IM by high-definition (HD) endoscopy and the diagnostic accuracy of this modality for IM among experienced and inexperienced endoscopists. Selected 50 cases, taken with HD endoscopy, were sent for a diagnostic inquiry of gastric IM through visual inspection to five experienced and five inexperienced endoscopists. The interobserver agreement between endoscopists was evaluated to verify the diagnostic reliability of HD endoscopy in diagnosing IM, and the diagnostic accuracy, sensitivity, and specificity were evaluated for validity of HD endoscopy in diagnosing IM. Interobserver agreement among the experienced endoscopists was "poor" (κ = 0.38) and it was also "poor" (κ = 0.33) among the inexperienced endoscopists. The diagnostic accuracy of the experienced endoscopists was superior to that of the inexperienced endoscopists (P = 0.003). Since diagnosis through visual inspection is unreliable in the diagnosis of IM, all suspicious areas for gastric IM should be considered to be biopsied. Furthermore, endoscopic experience and education are needed to raise the diagnostic accuracy of gastric IM. PMID:23678267

  16. Interobserver variability and accuracy of high-definition endoscopic diagnosis for gastric intestinal metaplasia among experienced and inexperienced endoscopists.

    Science.gov (United States)

    Hyun, Yil Sik; Han, Dong Soo; Bae, Joong Ho; Park, Hye Sun; Eun, Chang Soo

    2013-05-01

    Accurate diagnosis of gastric intestinal metaplasia is important; however, conventional endoscopy is known to be an unreliable modality for diagnosing gastric intestinal metaplasia (IM). The aims of the study were to evaluate the interobserver variation in diagnosing IM by high-definition (HD) endoscopy and the diagnostic accuracy of this modality for IM among experienced and inexperienced endoscopists. Selected 50 cases, taken with HD endoscopy, were sent for a diagnostic inquiry of gastric IM through visual inspection to five experienced and five inexperienced endoscopists. The interobserver agreement between endoscopists was evaluated to verify the diagnostic reliability of HD endoscopy in diagnosing IM, and the diagnostic accuracy, sensitivity, and specificity were evaluated for validity of HD endoscopy in diagnosing IM. Interobserver agreement among the experienced endoscopists was "poor" (κ = 0.38) and it was also "poor" (κ = 0.33) among the inexperienced endoscopists. The diagnostic accuracy of the experienced endoscopists was superior to that of the inexperienced endoscopists (P = 0.003). Since diagnosis through visual inspection is unreliable in the diagnosis of IM, all suspicious areas for gastric IM should be considered to be biopsied. Furthermore, endoscopic experience and education are needed to raise the diagnostic accuracy of gastric IM.

  17. "Live High-Train High" increases hemoglobin mass in Olympic swimmers

    DEFF Research Database (Denmark)

    Bonne, Thomas Christian; Lundby, Carsten; Jørgensen, Susanne

    2014-01-01

    PURPOSE: This study tested whether 3-4 weeks of classical "Live High-Train High" (LHTH) altitude training increases swim-specific VO2max through increased hemoglobin mass (Hbmass). METHODS: Ten swimmers lived and trained for more than 3 weeks between 2,130 and 3,094 m of altitude, and a control...

  18. AMS detection of actinides at high mass separation

    Energy Technology Data Exchange (ETDEWEB)

    Steier, Peter; Lachner, Johannes; Priller, Alfred; Winkler, Stephan; Golser, Robin [University of Vienna, Faculty of Physics, Vienna (Austria); Eigl, Rosmarie [Hiroshima University, Earth and Planetary Systems Science, Hiroshima (Japan); Quinto, Francesca [Institut fuer Nukleare Entsorgung, KIT, Eggenstein-Leopoldshafen (Germany); Sakaguchi, Aya [University of Tsukuba, Center for Research in Isotopes and Environmental Dynamics, Tsukuba (Japan)

    2015-07-01

    AMS is the mass spectrometric method with the highest abundance sensitivity, which is a prerequisite for measurement of the long-lived radioisotope {sup 236}U (t{sub 1/2}=23.4 million years). The most successful application so far is oceanography, since anthropogenic {sup 236}U is present in the world oceans at {sup 236}U:{sup 238}U from 10{sup -11} to 10{sup -8}. We have explored methods to increase the sensitivity and thus to reduce the water volume required to 1 L or less, which significantly reduces the sampling effort. High sensitivity is also necessary to address the expected typical natural isotopic ratios on the order {sup 236}U:{sup 238}U = 10{sup -13}, with potential applications in geology. With a second 90 analyzer magnet and a new Time-of-Flight beam line, VERA is robust against chemical impurities in the background, which e.g. allows measuring Pu isotopes directly in a uranium matrix. This simplifies chemical sample preparation for actinide detection, and may illustrate why AMS reaches lower detection limits than other mass spectrometric methods with nominally higher detection efficiency.

  19. High-accuracy waveforms for binary black hole inspiral, merger, and ringdown

    International Nuclear Information System (INIS)

    Scheel, Mark A.; Boyle, Michael; Chu, Tony; Matthews, Keith D.; Pfeiffer, Harald P.; Kidder, Lawrence E.

    2009-01-01

    The first spectral numerical simulations of 16 orbits, merger, and ringdown of an equal-mass nonspinning binary black hole system are presented. Gravitational waveforms from these simulations have accumulated numerical phase errors through ringdown of f /M=0.951 62±0.000 02, and the final black hole spin is S f /M f 2 =0.686 46±0.000 04.

  20. Thermal Stability of Magnetic Compass Sensor for High Accuracy Positioning Applications

    Directory of Open Access Journals (Sweden)

    Van-Tang PHAM

    2015-12-01

    Full Text Available Using magnetic compass sensors in angle measurements have a wide area of application such as positioning, robot, landslide, etc. However, one of the most phenomenal that affects to the accuracy of the magnetic compass sensor is the temperature. This paper presents two thermal stability schemes for improving performance of a magnetic compass sensor. The first scheme uses the feedforward structure to adjust the angle output of the compass sensor adapt to the variation of the temperature. The second scheme increases both the temperature working range and steady error performance of the sensor. In this scheme, we try to keep the temperature of the sensor is stable at the certain value (e.g. 25 oC by using a PID (proportional-integral-derivative controller and a heating/cooling generator. Many experiment scenarios have implemented to confirm the effectivity of these solutions.

  1. Hyperbolic Method for Dispersive PDEs: Same High-Order of Accuracy for Solution, Gradient, and Hessian

    Science.gov (United States)

    Mazaheri, Alireza; Ricchiuto, Mario; Nishikawa, Hiroaki

    2016-01-01

    In this paper, we introduce a new hyperbolic first-order system for general dispersive partial differential equations (PDEs). We then extend the proposed system to general advection-diffusion-dispersion PDEs. We apply the fourth-order RD scheme of Ref. 1 to the proposed hyperbolic system, and solve time-dependent dispersive equations, including the classical two-soliton KdV and a dispersive shock case. We demonstrate that the predicted results, including the gradient and Hessian (second derivative), are in a very good agreement with the exact solutions. We then show that the RD scheme applied to the proposed system accurately captures dispersive shocks without numerical oscillations. We also verify that the solution, gradient and Hessian are predicted with equal order of accuracy.

  2. High-accuracy energy formulas for the attractive two-site Bose-Hubbard model

    Science.gov (United States)

    Ermakov, Igor; Byrnes, Tim; Bogoliubov, Nikolay

    2018-02-01

    The attractive two-site Bose-Hubbard model is studied within the framework of the analytical solution obtained by the application of the quantum inverse scattering method. The structure of the ground and excited states is analyzed in terms of solutions of Bethe equations, and an approximate solution for the Bethe roots is given. This yields approximate formulas for the ground-state energy and for the first excited-state energy. The obtained formulas work with remarkable precision for a wide range of parameters of the model, and are confirmed numerically. An expansion of the Bethe state vectors into a Fock space is also provided for evaluation of expectation values, although this does not have accuracy similar to that of the energies.

  3. Accuracy and repeatability positioning of high-performancel athe for non-circular turning

    Directory of Open Access Journals (Sweden)

    Majda Paweł

    2017-11-01

    Full Text Available This paper presents research on the accuracy and repeatability of CNC axis positioning in an innovative lathe with an additional Xs axis. This axis is used to perform movements synchronized with the angular position of the main drive, i.e. the spindle, and with the axial feed along the Z axis. This enables the one-pass turning of non-circular surfaces, rope and trapezoidal threads, as well as the surfaces of rotary tools such as a gear cutting hob, etc. The paper presents and discusses the interpretation of results and the calibration effects of positioning errors in the lathe’s numerical control system. Finally, it shows the geometric characteristics of the rope thread turned at various spindle speeds, including before and after-correction of the positioning error of the Xs axis.

  4. Accuracy and repeatability positioning of high-performancel athe for non-circular turning

    Science.gov (United States)

    Majda, Paweł; Powałka, Bartosz

    2017-11-01

    This paper presents research on the accuracy and repeatability of CNC axis positioning in an innovative lathe with an additional Xs axis. This axis is used to perform movements synchronized with the angular position of the main drive, i.e. the spindle, and with the axial feed along the Z axis. This enables the one-pass turning of non-circular surfaces, rope and trapezoidal threads, as well as the surfaces of rotary tools such as a gear cutting hob, etc. The paper presents and discusses the interpretation of results and the calibration effects of positioning errors in the lathe's numerical control system. Finally, it shows the geometric characteristics of the rope thread turned at various spindle speeds, including before and after-correction of the positioning error of the Xs axis.

  5. A method of high accuracy clock synchronization by frequency following with VCXO

    International Nuclear Information System (INIS)

    Ma Yichao; Wu Jie; Zhang Jie; Song Hongzhi; Kong Yang

    2011-01-01

    In this paper, the principle of the synchronous protocol of the IEEE1588 is analyzed, and the factors that affect the accuracy of synchronization is summarized. Through the hardware timer in a microcontroller, we give the exactly the time when a package is sent or received. So synchronization of the distributed clocks can reach 1 μs in this way. Another method to improve precision of the synchronization is to replace the traditional fixed frequency crystal of the slave device, which needs to follow up the master clock, by an adjustable VCXO. So it is possible to fine tune the frequency of the distributed clocks, and reduce the drift of clock, which shows great benefit for the clock synchronization. A test measurement shows the synchronization of distribute clocks can be better than 10 ns using this method, which is more accurate than the method realized by software. (authors)

  6. Tuberculosis Patients Admitted with High Fever and Hilar Mass

    Directory of Open Access Journals (Sweden)

    Yusuf Aydemir

    2014-08-01

    Full Text Available Tuberculosis may occur with very different clinical and radiological features. Therefore, can be difficulties from time to time in the differential diagnosis. 22-year-old male patient with a history of drug use, presenting with high fever was admitted to the Infectious Diseases Clinic. Patient who fail to respond to empiric antibiotic therapy was transferred to our clinic due to the radiologically mass in the lung. Acid-fast bacilli were negative in sputum and bronchial lavage, tuberculosis was diagnosed with excision of the axillary lymphadenomegaly. Fever fell down with antituberculosis treatment and clinical improvement was observed. We present the case of tuberculosis which have with different clinical and radiological findings, in order to always keep in mind.

  7. Bayesian Peptide Peak Detection for High Resolution TOF Mass Spectrometry.

    Science.gov (United States)

    Zhang, Jianqiu; Zhou, Xiaobo; Wang, Honghui; Suffredini, Anthony; Zhang, Lin; Huang, Yufei; Wong, Stephen

    2010-11-01

    In this paper, we address the issue of peptide ion peak detection for high resolution time-of-flight (TOF) mass spectrometry (MS) data. A novel Bayesian peptide ion peak detection method is proposed for TOF data with resolution of 10 000-15 000 full width at half-maximum (FWHW). MS spectra exhibit distinct characteristics at this resolution, which are captured in a novel parametric model. Based on the proposed parametric model, a Bayesian peak detection algorithm based on Markov chain Monte Carlo (MCMC) sampling is developed. The proposed algorithm is tested on both simulated and real datasets. The results show a significant improvement in detection performance over a commonly employed method. The results also agree with expert's visual inspection. Moreover, better detection consistency is achieved across MS datasets from patients with identical pathological condition.

  8. New approach to 3-D, high sensitivity, high mass resolution space plasma composition measurements

    International Nuclear Information System (INIS)

    McComas, D.J.; Nordholt, J.E.

    1990-01-01

    This paper describes a new type of 3-D space plasma composition analyzer. The design combines high sensitivity, high mass resolution measurements with somewhat lower mass resolution but even higher sensitivity measurements in a single compact and robust design. While the lower resolution plasma measurements are achieved using conventional straight-through time-of-flight mass spectrometry, the high mass resolution measurements are made by timing ions reflected in a linear electric field (LEF), where the restoring force that an ion experiences is proportional to the depth it travels into the LEF region. Consequently, the ion's equation of motion in that dimension is that of a simple harmonic oscillator and its travel time is simply proportional to the square root of the ion's mass/charge (m/q). While in an ideal LEF, the m/q resolution can be arbitrarily high, in a real device the resolution is limited by the field linearity which can be achieved. In this paper we describe how a nearly linear field can be produced and discuss how the design can be optimized for various different plasma regimes and spacecraft configurations

  9. STTR Phase I: Low-Cost, High-Accuracy, Whole-Building Carbon Dioxide Monitoring for Demand Control Ventilation

    Energy Technology Data Exchange (ETDEWEB)

    Hallstrom, Jason; Ni, Zheng Richard

    2018-05-15

    This STTR Phase I project assessed the feasibility of a new CO2 sensing system optimized for low-cost, high-accuracy, whole-building monitoring for use in demand control ventilation. The focus was on the development of a wireless networking platform and associated firmware to provide signal conditioning and conversion, fault- and disruptiontolerant networking, and multi-hop routing at building scales to avoid wiring costs. Early exploration of a bridge (or “gateway”) to direct digital control services was also explored. Results of the project contributed to an improved understanding of a new electrochemical sensor for monitoring indoor CO2 concentrations, as well as the electronics and networking infrastructure required to deploy those sensors at building scales. New knowledge was acquired concerning the sensor’s accuracy, environmental response, and failure modes, and the acquisition electronics required to achieve accuracy over a wide range of CO2 concentrations. The project demonstrated that the new sensor offers repeatable correspondence with commercial optical sensors, with supporting electronics that offer gain accuracy within 0.5%, and acquisition accuracy within 1.5% across three orders of magnitude variation in generated current. Considering production, installation, and maintenance costs, the technology presents a foundation for achieving whole-building CO2 sensing at a price point below $0.066 / sq-ft – meeting economic feasibility criteria established by the Department of Energy. The technology developed under this award addresses obstacles on the critical path to enabling whole-building CO2 sensing and demand control ventilation in commercial retrofits, small commercial buildings, residential complexes, and other highpotential structures that have been slow to adopt these technologies. It presents an opportunity to significantly reduce energy use throughout the United States a

  10. High-efficiency thermal ionization sources for mass spectrometry

    International Nuclear Information System (INIS)

    Olivares, Jose A.

    1996-01-01

    A version of the thermal ionization cavity (TIC) source developed specifically for use in mass spectrometry is presented. The performance of this ion source has been characterized extensively both with the use of an isotope separator and a quadrupole mass spectrometer. A detailed description of the TIC source for mass spectrometry is given along with the performance characteristics observed

  11. Overview of the JYFLTRAP mass measurements and high-precision ...

    Indian Academy of Sciences (India)

    nuclei, the mass difference can be determined with much higher precision than would normally be possible since for the mass doublets the systematic uncertainties become ..... The two-neutron separation energies in N = 60 indicate the. 338 ... Masses of zinc isotopes (Z = 30) were measured up to 80Zn, providing valuable.

  12. High-accuracy CFD prediction methods for fluid and structure temperature fluctuations at T-junction for thermal fatigue evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Shaoxiang, E-mail: qian.shaoxiang@jgc.com [EN Technology Center, Process Technology Division, JGC Corporation, 2-3-1 Minato Mirai, Nishi-ku, Yokohama 220-6001 (Japan); Kanamaru, Shinichiro [EN Technology Center, Process Technology Division, JGC Corporation, 2-3-1 Minato Mirai, Nishi-ku, Yokohama 220-6001 (Japan); Kasahara, Naoto [Nuclear Engineering and Management, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

    2015-07-15

    Highlights: • Numerical methods for accurate prediction of thermal loading were proposed. • Predicted fluid temperature fluctuation (FTF) intensity is close to the experiment. • Predicted structure temperature fluctuation (STF) range is close to the experiment. • Predicted peak frequencies of FTF and STF also agree well with the experiment. • CFD results show the proposed numerical methods are of sufficiently high accuracy. - Abstract: Temperature fluctuations generated by the mixing of hot and cold fluids at a T-junction, which is widely used in nuclear power and process plants, can cause thermal fatigue failure. The conventional methods for evaluating thermal fatigue tend to provide insufficient accuracy, because they were developed based on limited experimental data and a simplified one-dimensional finite element analysis (FEA). CFD/FEA coupling analysis is expected as a useful tool for the more accurate evaluation of thermal fatigue. The present paper aims to verify the accuracy of proposed numerical methods of simulating fluid and structure temperature fluctuations at a T-junction for thermal fatigue evaluation. The dynamic Smagorinsky model (DSM) is used for large eddy simulation (LES) sub-grid scale (SGS) turbulence model, and a hybrid scheme (HS) is adopted for the calculation of convective terms in the governing equations. Also, heat transfer between fluid and structure is calculated directly through thermal conduction by creating a mesh with near wall resolution (NWR) by allocating grid points within the thermal boundary sub-layer. The simulation results show that the distribution of fluid temperature fluctuation intensity and the range of structure temperature fluctuation are remarkably close to the experimental results. Moreover, the peak frequencies of power spectrum density (PSD) of both fluid and structure temperature fluctuations also agree well with the experimental results. Therefore, the numerical methods used in the present paper are

  13. High-Throughput Screening Using Mass Spectrometry within Drug Discovery.

    Science.gov (United States)

    Rohman, Mattias; Wingfield, Jonathan

    2016-01-01

    In order to detect a biochemical analyte with a mass spectrometer (MS) it is necessary to ionize the analyte of interest. The analyte can be ionized by a number of different mechanisms, however, one common method is electrospray ionization (ESI). Droplets of analyte are sprayed through a highly charged field, the droplets pick up charge, and this is transferred to the analyte. High levels of salt in the assay buffer will potentially steal charge from the analyte and suppress the MS signal. In order to avoid this suppression of signal, salt is often removed from the sample prior to injection into the MS. Traditional ESI MS relies on liquid chromatography (LC) to remove the salt and reduce matrix effects, however, this is a lengthy process. Here we describe the use of RapidFire™ coupled to a triple-quadrupole MS for high-throughput screening. This system uses solid-phase extraction to de-salt samples prior to injection, reducing processing time such that a sample is injected into the MS ~every 10 s.

  14. HCN Polymers: Toward Structure Comprehension Using High Resolution Mass Spectrometry

    Science.gov (United States)

    Bonnet, Jean-Yves; Thissen, Roland; Frisari, Ma; Vuitton, Veronique; Quirico, Eric; Le Roy, Léna; Fray, Nicolas; Cottin, Hervé; Horst, Sarah; Yelle, Roger

    A lot of solar system materials, including cometary ices and Titan aerosols, contain dark matter that can be interpreted as complex nitrogen bearing organic matter [1]. In laboratory experi-ments, HCN polymers are thus analogs of great interest. In fact they may be present in Titan atmosphere and in comet nuclei and then reprocessed as a CN distributed source [2], when ices began to sublimate and ejects from the nucleus organic matter grains [3]. The presence of HCN polymers is suggested because HCN molecule has been directly observed in 1P/Halley comet [4] and others. HCN polymers are also of prebiotic interest [5] as it can form amino acid under hydrolysis conditions. Even if they have been studied during the last decades, their chemical composition and structure are still poorly understood, and a great analytical effort has to be continued. In this way we present a high resolution mass spectrometry (HRMS) and a high resolution tandem mass spectrometry (MS/HRMS) analysis of HCN polymers. It was shown [6] that this is a suitable technique to elucidate composition and structure of the soluble part of tholins analogs of Titan's atmosphere aerosols. HCN polymers have never been studied by HRMS, thus we used a LTQ-Orbitrap XL high resolution mass spectrometer to analyse the HCN polymers. These are produced at LISA by direct polymerisation of pure liquid HCN, catalyzed by ammonia. HCN polymers have been completely dissolved in methanol and then injected in the mass spectrometer by ElectroSpray Ionization (ESI). This atmospheric pressure ionization process produces protonated or deprotonated ions, but it does not fragment molecules. Thus HRMS, allows a direct access to the stoechiometry of all the ionizable molecules present in the samples. Fragmentation analyses (MS/MS) of selected ions have also been performed. Thess analysis provide information about the different chemical fonctionnalities present in HCN poly-mers and also about their structure. Thus we are able to

  15. High-precision predictions for the light CP-even Higgs boson mass of the minimal supersymmetric standard model.

    Science.gov (United States)

    Hahn, T; Heinemeyer, S; Hollik, W; Rzehak, H; Weiglein, G

    2014-04-11

    For the interpretation of the signal discovered in the Higgs searches at the LHC it will be crucial in particular to discriminate between the minimal Higgs sector realized in the standard model (SM) and its most commonly studied extension, the minimal supersymmetric standard model (MSSM). The measured mass value, having already reached the level of a precision observable with an experimental accuracy of about 500 MeV, plays an important role in this context. In the MSSM the mass of the light CP-even Higgs boson, Mh, can directly be predicted from the other parameters of the model. The accuracy of this prediction should at least match the one of the experimental result. The relatively high mass value of about 126 GeV has led to many investigations where the scalar top quarks are in the multi-TeV range. We improve the prediction for Mh in the MSSM by combining the existing fixed-order result, comprising the full one-loop and leading and subleading two-loop corrections, with a resummation of the leading and subleading logarithmic contributions from the scalar top sector to all orders. In this way for the first time a high-precision prediction for the mass of the light CP-even Higgs boson in the MSSM is possible all the way up to the multi-TeV region of the relevant supersymmetric particles. The results are included in the code FEYNHIGGS.

  16. Accurate and precise 40Ar/39Ar dating by high-resolution, multi-collection, mass spectrometry

    DEFF Research Database (Denmark)

    Storey, Michael; Rivera, Tiffany; Flude, Stephanie

    New generation, high resolution, multi-collector noble gas mass spectrometers equipped with ion-counting electron multipliers provide opportunities for improved accuracy and precision in 40Ar/39Ar dating. Here we report analytical protocols and age cross-calibration studies using a NU-Instruments......New generation, high resolution, multi-collector noble gas mass spectrometers equipped with ion-counting electron multipliers provide opportunities for improved accuracy and precision in 40Ar/39Ar dating. Here we report analytical protocols and age cross-calibration studies using a NU......-Instruments multi-collector Noblesse noble gas mass spectrometer configured with a faraday detector and three ion-counting electron multipliers. The instrument has the capability to measure several noble gas isotopes simultaneously and to change measurement configurations instantaneously by the use of QUAD lenses...... (zoom optics). The Noblesse offer several advantages over previous generation noble gas mass spectrometers and is particularly suited for single crystal 40Ar/39Ar dating because of: (i) improved source sensitivity (ii) ion-counting electron multipliers, which have much lower signal to noise ratios than...

  17. MASH Suite: a user-friendly and versatile software interface for high-resolution mass spectrometry data interpretation and visualization.

    Science.gov (United States)

    Guner, Huseyin; Close, Patrick L; Cai, Wenxuan; Zhang, Han; Peng, Ying; Gregorich, Zachery R; Ge, Ying

    2014-03-01

    The rapid advancements in mass spectrometry (MS) instrumentation, particularly in Fourier transform (FT) MS, have made the acquisition of high-resolution and high-accuracy mass measurements routine. However, the software tools for the interpretation of high-resolution MS data are underdeveloped. Although several algorithms for the automatic processing of high-resolution MS data are available, there is still an urgent need for a user-friendly interface with functions that allow users to visualize and validate the computational output. Therefore, we have developed MASH Suite, a user-friendly and versatile software interface for processing high-resolution MS data. MASH Suite contains a wide range of features that allow users to easily navigate through data analysis, visualize complex high-resolution MS data, and manually validate automatically processed results. Furthermore, it provides easy, fast, and reliable interpretation of top-down, middle-down, and bottom-up MS data. MASH Suite is convenient, easily operated, and freely available. It can greatly facilitate the comprehensive interpretation and validation of high-resolution MS data with high accuracy and reliability.

  18. Radiometric inter-sensor cross-calibration uncertainty using a traceable high accuracy reference hyperspectral imager

    Science.gov (United States)

    Gorroño, Javier; Banks, Andrew C.; Fox, Nigel P.; Underwood, Craig

    2017-08-01

    Optical earth observation (EO) satellite sensors generally suffer from drifts and biases relative to their pre-launch calibration, caused by launch and/or time in the space environment. This places a severe limitation on the fundamental reliability and accuracy that can be assigned to satellite derived information, and is particularly critical for long time base studies for climate change and enabling interoperability and Analysis Ready Data. The proposed TRUTHS (Traceable Radiometry Underpinning Terrestrial and Helio-Studies) mission is explicitly designed to address this issue through re-calibrating itself directly to a primary standard of the international system of units (SI) in-orbit and then through the extension of this SI-traceability to other sensors through in-flight cross-calibration using a selection of Committee on Earth Observation Satellites (CEOS) recommended test sites. Where the characteristics of the sensor under test allows, this will result in a significant improvement in accuracy. This paper describes a set of tools, algorithms and methodologies that have been developed and used in order to estimate the radiometric uncertainty achievable for an indicative target sensor through in-flight cross-calibration using a well-calibrated hyperspectral SI-traceable reference sensor with observational characteristics such as TRUTHS. In this study, Multi-Spectral Imager (MSI) of Sentinel-2 and Landsat-8 Operational Land Imager (OLI) is evaluated as an example, however the analysis is readily translatable to larger-footprint sensors such as Sentinel-3 Ocean and Land Colour Instrument (OLCI) and Visible Infrared Imaging Radiometer Suite (VIIRS). This study considers the criticality of the instrumental and observational characteristics on pixel level reflectance factors, within a defined spatial region of interest (ROI) within the target site. It quantifies the main uncertainty contributors in the spectral, spatial, and temporal domains. The resultant tool

  19. The high accuracy data processing system of laser interferometry signals based on MSP430

    Science.gov (United States)

    Qi, Yong-yue; Lin, Yu-chi; Zhao, Mei-rong

    2009-07-01

    Generally speaking there are two orthogonal signals used in single-frequency laser interferometer for differentiating direction and electronic subdivision. However there usually exist three errors with the interferential signals: zero offsets error, unequal amplitude error and quadrature phase shift error. These three errors have a serious impact on subdivision precision. Based on Heydemann error compensation algorithm, it is proposed to achieve compensation of the three errors. Due to complicated operation of the Heydemann mode, a improved arithmetic is advanced to decrease the calculating time effectively in accordance with the special characteristic that only one item of data will be changed in each fitting algorithm operation. Then a real-time and dynamic compensatory circuit is designed. Taking microchip MSP430 as the core of hardware system, two input signals with the three errors are turned into digital quantity by the AD7862. After data processing in line with improved arithmetic, two ideal signals without errors are output by the AD7225. At the same time two original signals are turned into relevant square wave and imported to the differentiating direction circuit. The impulse exported from the distinguishing direction circuit is counted by the timer of the microchip. According to the number of the pulse and the soft subdivision the final result is showed by LED. The arithmetic and the circuit are adopted to test the capability of a laser interferometer with 8 times optical path difference and the measuring accuracy of 12-14nm is achieved.

  20. A new phase-shift microscope designed for high accuracy stitching interferometry

    International Nuclear Information System (INIS)

    Thomasset, Muriel; Idir, Mourad; Polack, François; Bray, Michael; Servant, Jean-Jacques

    2013-01-01

    Characterizing nanofocusing X-ray mirrors for the soon coming nano-imaging beamlines of synchrotron light sources motivates the development of new instruments with improved performances. The sensitivity and accuracy goal is now fixed well under the nm level and, at the same time, the spatial frequency range of the measurement should be pushed toward 50 mm −1 . SOLEIL synchrotron facility has therefore undertaken to equip with an interferential microscope suitable for stitching interferometry at this performance level. In order to keep control on the whole metrology chain it was decided to build a custom instrument in partnership with two small optics companies EOTECH and MBO. The new instrument is a Michelson micro-interferometer equipped with a custom-designed telecentric objective. It achieves the large depth of focus suitable for performing reliable calibrations and measurements. The concept has been validated with a predevelopment set-up, delivered in July 2010, which showed a static repeatability below 1 nm PV despite a non-thermally stabilized environment. The final instrument was delivered early this year and was installed inside SOLEIL's controlled environment facility, where thorough characterization tests are under way. Latest test results and first stitching measurements are presented

  1. Experimental study of very low permeability rocks using a high accuracy permeameter

    International Nuclear Information System (INIS)

    Larive, Elodie

    2002-01-01

    The measurement of fluid flow through 'tight' rocks is important to provide a better understanding of physical processes involved in several industrial and natural problems. These include deep nuclear waste repositories, management of aquifers, gas, petroleum or geothermal reservoirs, or earthquakes prevention. The major part of this work consisted of the design, construction and use of an elaborate experimental apparatus allowing laboratory permeability measurements (fluid flow) of very low permeability rocks, on samples at a centimetric scale, to constrain their hydraulic behaviour at realistic in-situ conditions. The accuracy permeameter allows the use of several measurement methods, the steady-state flow method, the transient pulse method, and the sinusoidal pore pressure oscillation method. Measurements were made with the pore pressure oscillation method, using different waveform periods, at several pore and confining pressure conditions, on different materials. The permeability of one natural standard, Westerly granite, and an artificial one, a micro-porous cement, were measured, and results obtained agreed with previous measurements made on these materials showing the reliability of the permeameter. A study of a Yorkshire sandstone shows a relationship between rock microstructure, permeability anisotropy and thermal cracking. Microstructure, porosity and permeability concepts, and laboratory permeability measurements specifications are presented, the permeameter is described, and then permeability results obtained on the investigated materials are reported [fr

  2. Demonstrating High-Accuracy Orbital Access Using Open-Source Tools

    Science.gov (United States)

    Gilbertson, Christian; Welch, Bryan

    2017-01-01

    Orbit propagation is fundamental to almost every space-based analysis. Currently, many system analysts use commercial software to predict the future positions of orbiting satellites. This is one of many capabilities that can replicated, with great accuracy, without using expensive, proprietary software. NASAs SCaN (Space Communication and Navigation) Center for Engineering, Networks, Integration, and Communications (SCENIC) project plans to provide its analysis capabilities using a combination of internal and open-source software, allowing for a much greater measure of customization and flexibility, while reducing recurring software license costs. MATLAB and the open-source Orbit Determination Toolbox created by Goddard Space Flight Center (GSFC) were utilized to develop tools with the capability to propagate orbits, perform line-of-sight (LOS) availability analyses, and visualize the results. The developed programs are modular and can be applied for mission planning and viability analysis in a variety of Solar System applications. The tools can perform 2 and N-body orbit propagation, find inter-satellite and satellite to ground station LOS access (accounting for intermediate oblate spheroid body blocking, geometric restrictions of the antenna field-of-view (FOV), and relativistic corrections), and create animations of planetary movement, satellite orbits, and LOS accesses. The code is the basis for SCENICs broad analysis capabilities including dynamic link analysis, dilution-of-precision navigation analysis, and orbital availability calculations.

  3. A study for high accuracy measurement of residual stress by deep hole drilling technique

    Science.gov (United States)

    Kitano, Houichi; Okano, Shigetaka; Mochizuki, Masahito

    2012-08-01

    The deep hole drilling technique (DHD) received much attention in recent years as a method for measuring through-thickness residual stresses. However, some accuracy problems occur when residual stress evaluation is performed by the DHD technique. One of the reasons is that the traditional DHD evaluation formula applies to the plane stress condition. The second is that the effects of the plastic deformation produced in the drilling process and the deformation produced in the trepanning process are ignored. In this study, a modified evaluation formula, which is applied to the plane strain condition, is proposed. In addition, a new procedure is proposed which can consider the effects of the deformation produced in the DHD process by investigating the effects in detail by finite element (FE) analysis. Then, the evaluation results obtained by the new procedure are compared with that obtained by traditional DHD procedure by FE analysis. As a result, the new procedure evaluates the residual stress fields better than the traditional DHD procedure when the measuring object is thick enough that the stress condition can be assumed as the plane strain condition as in the model used in this study.

  4. On a novel low cost high accuracy experimental setup for tomographic particle image velocimetry

    International Nuclear Information System (INIS)

    Discetti, Stefano; Ianiro, Andrea; Astarita, Tommaso; Cardone, Gennaro

    2013-01-01

    This work deals with the critical aspects related to cost reduction of a Tomo PIV setup and to the bias errors introduced in the velocity measurements by the coherent motion of the ghost particles. The proposed solution consists of using two independent imaging systems composed of three (or more) low speed single frame cameras, which can be up to ten times cheaper than double shutter cameras with the same image quality. Each imaging system is used to reconstruct a particle distribution in the same measurement region, relative to the first and the second exposure, respectively. The reconstructed volumes are then interrogated by cross-correlation in order to obtain the measured velocity field, as in the standard tomographic PIV implementation. Moreover, differently from tomographic PIV, the ghost particle distributions of the two exposures are uncorrelated, since their spatial distribution is camera orientation dependent. For this reason, the proposed solution promises more accurate results, without the bias effect of the coherent ghost particles motion. Guidelines for the implementation and the application of the present method are proposed. The performances are assessed with a parametric study on synthetic experiments. The proposed low cost system produces a much lower modulation with respect to an equivalent three-camera system. Furthermore, the potential accuracy improvement using the Motion Tracking Enhanced MART (Novara et al 2010 Meas. Sci. Technol. 21 035401) is much higher than in the case of the standard implementation of tomographic PIV. (paper)

  5. The influence of different referencing methods on the accuracy of δ(13) C value measurement of ethanol fuel by gas chromatography/combustion/isotope ratio mass spectrometry.

    Science.gov (United States)

    Neves, Laura A; Rodrigues, Janaína M; Daroda, Romeu J; Silva, Paulo R M; Ferreira, Alexandre A; Aranda, Donato A G; Eberlin, Marcos N; Fasciotti, Maíra

    2015-11-15

    Brazil is the largest producer of sugar cane bioethanol in the world. Isotope ratio mass spectrometry (IRMS) is the technique of choice to certify the origin/raw materials for ethanol production, but the lack of certified reference materials (CRMs) for accurate measurements of δ(13) C values traceable to Vienna Pee Dee Belemnite (VPDB), the international zero point for (13) C/(12) C measurements, certified and compatible with gas chromatography (GC)/IRMS instruments may compromise the accuracy of δ(13) C determinations. We evaluated the influence of methods for the calibration and normalization of raw δ(13) C values of ethanol samples. Samples were analyzed by GC/C/IRMS using two different GC columns. Different substances were used as isotopic standards for the working gas calibration. The δ(13) C values obtained with the three methods of normalization were statistically compared with those obtained with elemental analyzer (EA)/IRMS, since the δ(13) C results obtained using EA are traceable to VPDB via the NBS 22 reference material. It was observed that both the isotopic reference material for CO2 calibration and the GC column have a major effect on the δ(13) C measurements, leading to a bias of almost 2-3 ‰ in the δ(13) C values. All three methods of normalization were equivalent in performance, enabling an improvement in the GC/C/IRMS accuracy, compared with the EA/IRMS reference values for the samples. All the methods of CO2 calibration, chromatography and normalization presented in this work demonstrated several sources of traceability and accuracy loss for the determination of δ(13) C values in ethanol fuel samples by GC/C/IRMS. This work has also shown the importance of using proper CRMs traceable to VPBD that should be compatible and certified using GC/C/IRMS, ideally in a wide range of δ(13) C values. This is important not only for bioethanol fuel samples, but also for many analytes commonly analyzed by IRMS. Copyright © 2015 John Wiley & Sons

  6. ISPA - a high accuracy X-ray and gamma camera Exhibition LEPFest 2000

    CERN Multimedia

    2000-01-01

    ISPA offers ... Ten times better resolution than Anger cameras High efficiency single gamma counting Noise reduction by sensitivity to gamma energy ...for Single Photon Emission Computed Tomography (SPECT)

  7. Searches for high-mass supersymmetry using masses of large-radius jets

    CERN Document Server

    Heller, Ryan

    2016-01-01

    Results are reported from two searches for supersymmetric particles in final states with multiple jets, including several b-tagged jets, with and without large missing transverse momentum. The data sample corresponds to 2.3 fb − 1 (2.7 fb − 1 without missing transverse momentum) of pp collisions recorded by the CMS experiment at √ s = 13 TeV. The searches focus on processes with massive, high multiplicity final states, such as gluino pair production with the gluino decaying to top quarks and a neutralino, and gluino pair production with R-parity violating gluino decay to top, bottom and strange quarks. Both searches use the quantity M J , the sum of the masses of the large-radius jets, to discriminate between signal and background, establish control regions for other discriminating variables, and as a central piece of the background estimation. The observed event yields are consistent with the standard model expectations, and the results are interpreted in terms of limits on simplified supersymmetric mo...

  8. Gated viewing and high-accuracy three-dimensional laser radar

    DEFF Research Database (Denmark)

    Busck, Jens; Heiselberg, Henning

    2004-01-01

    , a high PRF of 32 kHz, and a high-speed camera with gate times down to 200 ps and delay steps down to 100 ps. The electronics and the software also allow for gated viewing with automatic gain control versus range, whereby foreground backscatter can be suppressed. We describe our technique for the rapid...

  9. Extending and refining the mass surface around $^{208}$Pb by high-precision Penning-trap mass spectrometry with ISOLTRAP

    CERN Multimedia

    Herfurth, F; Stora, T; Blaum, K; Beck, D; Kowalska, M; Schwarz, S; Stanja, J; Herlert, A J; Yamaguchi, T

    We propose high-precision mass spectrometry of nuclides around the doubly magic $^{208}$Pb. On the neutron-rich side, we aim to extend the knowledge of Fr, At, Hg, and Au masses to study the robustness of the N = 126 shell closure and to provide mass data necessary for modeling the rapid-neutron-capture process. On the proton-rich side, we aim at high-resolution mass spectrometry of selected Au, At, and Fr isotopes to verify the predicted existence of very low-lying isomeric states. The proposal will make use of newly-available laser-ionization schemes for Au and At. Finally, the recently implemented multi-reflection time-of-flight mass separator for auxiliary isobaric purification now allows measurements which were not feasible before.

  10. Accurate screening for synthetic preservatives in beverage using high performance liquid chromatography with time-of-flight mass spectrometry

    International Nuclear Information System (INIS)

    Li Xiuqin; Zhang Feng; Sun Yanyan; Yong Wei; Chu Xiaogang; Fang Yanyan; Zweigenbaum, Jerry

    2008-01-01

    In this study, liquid chromatography time-of-flight mass spectrometry (HPLC/TOF-MS) is applied to qualitation and quantitation of 18 synthetic preservatives in beverage. The identification by HPLC/TOF-MS is accomplished with the accurate mass (the subsequent generated empirical formula) of the protonated molecules [M + H]+ or the deprotonated molecules [M - H]-, along with the accurate mass of their main fragment ions. In order to obtain sufficient sensitivity for quantitation purposes (using the protonated or deprotonated molecule) and additional qualitative mass spectrum information provided by the fragments ions, segment program of fragmentor voltages is designed in positive and negative ion mode, respectively. Accurate mass measurements are highly useful in the complex sample analyses since they allow us to achieve a high degree of specificity, often needed when other interferents are present in the matrix. The mass accuracy typically obtained is routinely better than 3 ppm. The 18 compounds behave linearly in the 0.005-5.0 mg.kg -1 concentration range, with correlation coefficient >0.996. The recoveries at the tested concentrations of 1.0 mg.kg -1 -100 mg.kg -1 are 81-106%, with coefficients of variation -1 , which are far below the required maximum residue level (MRL) for these preservatives in foodstuff. The method is suitable for routine quantitative and qualitative analyses of synthetic preservatives in foodstuff

  11. High-accuracy measurement of ship velocities by DGPS; DGPS ni yoru sensoku keisoku no koseidoka ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, S; Koterayama, W [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics

    1996-04-10

    The differential global positioning system (DGPS) can eliminate most of errors in ship velocity measurement by GPS positioning alone. Through two rounds of marine observations by towing an observation robot in summer 1995, the authors attempted high-accuracy measurement of ship velocities by DGPS, and also carried out both positioning by GPS alone and measurement using the bottom track of ADCP (acoustic Doppler current profiler). In this paper, the results obtained by these measurement methods were examined through comparison among them, and the accuracy of the measured ship velocities was considered. In DGPS measurement, both translocation method and interference positioning method were used. ADCP mounted on the observation robot allowed measurement of the velocity of current meter itself by its bottom track in shallow sea areas less than 350m. As the result of these marine observations, it was confirmed that the accuracy equivalent to that of direct measurement by bottom track is possible to be obtained by DGPS. 3 refs., 5 figs., 1 tab.

  12. High construal level can help negotiators to reach integrative agreements: The role of information exchange and judgement accuracy.

    Science.gov (United States)

    Wening, Stefanie; Keith, Nina; Abele, Andrea E

    2016-06-01

    In negotiations, a focus on interests (why negotiators want something) is key to integrative agreements. Yet, many negotiators spontaneously focus on positions (what they want), with suboptimal outcomes. Our research applies construal-level theory to negotiations and proposes that a high construal level instigates a focus on interests during negotiations which, in turn, positively affects outcomes. In particular, we tested the notion that the effect of construal level on outcomes was mediated by information exchange and judgement accuracy. Finally, we expected the mere mode of presentation of task material to affect construal levels and manipulated construal levels using concrete versus abstract negotiation tasks. In two experiments, participants negotiated in dyads in either a high- or low-construal-level condition. In Study 1, high-construal-level dyads outperformed dyads in the low-construal-level condition; this main effect was mediated by information exchange. Study 2 replicated both the main and mediation effects using judgement accuracy as mediator and additionally yielded a positive effect of a high construal level on a second, more complex negotiation task. These results not only provide empirical evidence for the theoretically proposed link between construal levels and negotiation outcomes but also shed light on the processes underlying this effect. © 2015 The British Psychological Society.

  13. Multicomponent mixed dopant optimization for rapid screening of polycyclic aromatic hydrocarbons using ultra high performance liquid chromatography coupled to atmospheric pressure photoionization high-resolution mass spectrometry

    KAUST Repository

    Sioud, Salim

    2012-05-04

    RATIONALE To enhance the ionization efficiencies in atmospheric pressure photoionization mass spectrometry a dopant with favorable ionization energy such as chlorobenzene is typically used. These dopants are typically toxic and difficult to mix with water-soluble organic solvents. In order to achieve a more efficient and less toxic dopant, a multicomponent mixed dopant was explored. METHODS A multicomponent mixed dopant for non-targeted rapid screening of polycyclic aromatic hydrocarbons (PAHs) was developed and optimized using ultra high performance liquid chromatography (UPLC) coupled to atmospheric pressure photoionization high-resolution mass spectrometry. Various single and multicomponent mixed dopants consisting of ethanol, chlorobenzene, bromobenzene, anisole and toluene were evaluated. RESULTS Fourteen out of eighteen PAHs were successfully separated and detected at low pg/μL levels within 5 min with high mass accuracy ≤4 ppm. The optimal mixed multicomponent dopant consisted of ethanol/chlorobenzene/bromobenzene/anisole (98.975:0.1:0.9:0.025, v/v %) and it improved the limit of detection (LOD) by 2- to 10-fold for the tested PAHs compared to those obtained with pure chlorobenzene. CONCLUSIONS A novel multicomponent dopant that contains 99% ethanol and 1% mixture of chlorobenzene, bromobenzene and anisole was found to be an effective dopant mixture to ionize PAHs. The developed UPLC multicomponent dopant assisted atmospheric pressure photoionization high-resolution mass spectrometry offered a rapid non targeted screening method for detecting the PAHs at low pg/;μL levels within a 5 min run time with high mass accuracy a;circ4 ppm. Copyright © 2012 John Wiley & Sons, Ltd.

  14. High throughput reaction screening using desorption electrospray ionization mass spectrometry.

    Science.gov (United States)

    Wleklinski, Michael; Loren, Bradley P; Ferreira, Christina R; Jaman, Zinia; Avramova, Larisa; Sobreira, Tiago J P; Thompson, David H; Cooks, R Graham

    2018-02-14

    We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging. Desorption electrospray ionization (DESI) mass spectrometry (MS) is applied in a continuous on-line process at rates that approach 10 4 reactions per h at area densities of up to 1 spot per mm 2 (6144 spots per standard microtiter plate) with the sprayer moving at ca. 10 4 microns per s. Data are analyzed automatically by MS using in-house software to create ion images of selected reagents and products as intensity plots in standard array format. Amine alkylation reactions were used to optimize the system performance on PTFE membrane substrates using methanol as the DESI spray/analysis solvent. Reaction times can be screening of processes like N -alkylation and Suzuki coupling reactions as reported herein. Products and by-products were confirmed by on-line MS/MS upon rescanning of the array.

  15. A content analysis of the quantity and accuracy of dietary supplement information found in magazines with high adolescent readership.

    Science.gov (United States)

    Shaw, Patricia; Zhang, Vivien; Metallinos-Katsaras, Elizabeth

    2009-02-01

    The objective of this study was to examine the quantity and accuracy of dietary supplement (DS) information through magazines with high adolescent readership. Eight (8) magazines (3 teen and 5 adult with high teen readership) were selected. A content analysis for DS was conducted on advertisements and editorials (i.e., articles, advice columns, and bulletins). Noted claims/cautions regarding DS were evaluated for accuracy using Medlineplus.gov and Naturaldatabase.com. Claims for dietary supplements with three or more types of ingredients and those in advertisements were not evaluated. Advertisements were evaluated with respect to size, referenced research, testimonials, and Dietary Supplement Health and Education Act of 1994 (DSHEA) warning visibility. Eighty-eight (88) issues from eight magazines yielded 238 DS references. Fifty (50) issues from five magazines contained no DS reference. Among teen magazines, seven DS references were found: five in the editorials and two in advertisements. In adult magazines, 231 DS references were found: 139 in editorials and 92 in advertisements. Of the 88 claims evaluated, 15% were accurate, 23% were inconclusive, 3% were inaccurate, 5% were partially accurate, and 55% were unsubstantiated (i.e., not listed in reference databases). Of the 94 DS evaluated in advertisements, 43% were full page or more, 79% did not have a DSHEA warning visible, 46% referred to research, and 32% used testimonials. Teen magazines contain few references to DS, none accurate. Adult magazines that have a high teen readership contain a substantial amount of DS information with questionable accuracy, raising concerns that this information may increase the chances of inappropriate DS use by adolescents, thereby increasing the potential for unexpected effects or possible harm.

  16. A fragmentation study of kaempferol using electrospray quadrupole time-of-flight mass spectrometry at high mass resolution

    Science.gov (United States)

    March, Raymond E.; Miao, Xiu-Sheng

    2004-02-01

    A mass spectrometric method based on the combined use of electrospray ionization, collision-induced dissociation and tandem mass spectrometry at high mass resolution has been applied to an investigation of the structural characterization of protonated and deprotonated kaempferol (3,5,7,4'-tetrahydroxyflavone). Low-energy product ion mass spectra of [M+H]+ ions showed simple fragmentations of the C ring that permitted characterization of the substituents in the A and B rings. In addition, four rearrangement reactions accompanied by losses of C2H2O, CHO[radical sign], CO, and H2O were observed. Low-energy product ion mass spectra of [M-H]- ions showed only four rearrangement reactions accompanied by losses of OH[radical sign], CO, CH2O, and C2H2O. The use of elevated cone voltages permitted observation of product ion mass spectra of selected primary and secondary fragment ions so that each fragment ion reported was observed as a direct product of its immediate precursor ion. Product ion mass spectra examined at high mass resolution allowed unambiguous determination of the elemental composition of fragment ions and resolution of two pairs of isobars. Fragmentation mechanisms and ion structures have been proposed.

  17. PET/CT-guided percutaneous liver mass biopsies and ablations: Targeting accuracy of a single 20 s breath-hold PET acquisition

    International Nuclear Information System (INIS)

    Shyn, P.B.; Tatli, S.; Sahni, V.A.; Sadow, C.A.; Forgione, K.; Mauri, G.; Morrison, P.R.; Catalano, P.J.; Silverman, S.G.

    2014-01-01

    Aim: To determine whether a single 20 s breath-hold positron-emission tomography (PET) acquisition obtained during combined PET/computed tomography (CT)-guided percutaneous liver biopsy or ablation procedures has the potential to target 2-[ 18 F]-fluoro-2-deoxy-D-glucose (FDG)-avid liver masses as accurately as up to 180 s breath-hold PET acquisitions. Materials and methods: This retrospective study included 10 adult patients with 13 liver masses who underwent FDG PET/CT-guided percutaneous biopsies (n = 5) or ablations (n = 5). PET was acquired as nine sequential 20 s, monitored, same-level breath-hold frames and CT was acquired in one monitored breath-hold. Twenty, 40, 60, and 180 s PET datasets were reconstructed. Two blinded readers marked tumour centres on randomized PET and CT datasets. Three-dimensional spatial localization differences between PET datasets and either 180 s PET or CT were analysed using multiple regression analyses. Statistical tests were two-sided and p < 0.05 was considered significant. Results: Targeting differences between 20 s PET and 180 s PET ranged from 0.7–20.3 mm (mean 5.3 ± 4.4 mm; median 4.3) and were not statistically different from 40 or 60 s PET (p = 0.74 and 0.91, respectively). Targeting differences between 20 s PET and CT ranged from 1.4–36 mm (mean 9.6 ± 7.1 mm; median 8.2 mm) and were not statistically different from 40, 60, or 180 s PET (p = 0.84, 0.77, and 0.35, respectively). Conclusion: Single 20 s breath-hold PET acquisitions from PET/CT-guided percutaneous liver procedures have the potential to target FDG-avid liver masses with equivalent accuracy to 180 s summed, breath-hold PET acquisitions and may facilitate strategies that improve image registration and shorten procedure times

  18. High-mass Star Formation and Its Initial Conditions

    Science.gov (United States)

    Zhang, C. P.

    2017-11-01

    In this thesis, we present four works on the infrared dark clouds, fragmentation and deuteration of compact and cold cores, hyper-compact (HC) HII regions, and infrared dust bubbles, respectively. They are not only the products of early high-mass star formation, but reflect different evolutionary sequences of high-mass star formation. (1) Using the IRAM (Institut de Radioastronomie Millimétrique) 30 m telescope, we obtained HCO^+, HNC, N_2^+, and C^{18}O emission in six IRDCs (infrared dark clouds), and study their dynamics, stability, temperature, and density. (2) Fragmentation at the earliest phases is an important process of massive star formation. Eight massive precluster clumps (G18.17, G18.21, G23.97N, G23.98, G23.44, G23.97S, G25.38, and G25.71) were selected from the SCUBA (submillimetre Common-User Bolometer Array) 850 μm and 450 μm data. The VLA (Very Large Array) at 1.3 cm, PbBI at 3.5 mm and 1.3 mm, APEX (Atacama Pathfinder Experiment telescope) at 870 μm observations were followed up, and archival infrared data at 4.5 μm, 8.0 μm, 24 μm, and 70 μm were combined to study the fragmentation and evolution of these clumps. We explored the habitats of the massive clumps at large scale, cores/condensations at small scale, and the fragmentation process at different wavelengths. Star formation in these eight clumps may have been triggered by the UC (ultra-compact) HII regions nearby. (3) The formation of hyper-compact (HC) HII regions is an important stage in massive star formation. We present high angular resolution observations carried out with the SMA (Submillimeter Array) and the VLA (Very Large Array) toward the HC HII region G35.58-0.03. With the 1.3 mm SMA and 1.3 cm VLA, we detected a total of about 25 transitions of 8 different species and their isotopologues (CO, CH_3CN, SO_2, CH_3CCH, OCS, CS, H30α/38β, and NH_{3}). G35.58-0.03 consists of an HC HII core with electron temperature Te* ≥ 5500 K, emission measure EM ≈ 1.9×10^{9} pc

  19. High Accuracy Three-dimensional Simulation of Micro Injection Moulded Parts

    DEFF Research Database (Denmark)

    Tosello, Guido; Costa, F. S.; Hansen, Hans Nørgaard

    2011-01-01

    Micro injection moulding (μIM) is the key replication technology for high precision manufacturing of polymer micro products. Data analysis and simulations on micro-moulding experiments have been conducted during the present validation study. Detailed information about the μIM process was gathered...

  20. Museum genomics: low-cost and high-accuracy genetic data from historical specimens.

    Science.gov (United States)

    Rowe, Kevin C; Singhal, Sonal; Macmanes, Matthew D; Ayroles, Julien F; Morelli, Toni Lyn; Rubidge, Emily M; Bi, Ke; Moritz, Craig C

    2011-11-01

    Natural history collections are unparalleled repositories of geographical and temporal variation in faunal conditions. Molecular studies offer an opportunity to uncover much of this variation; however, genetic studies of historical museum specimens typically rely on extracting highly degraded and chemically modified DNA samples from skins, skulls or other dried samples. Despite this limitation, obtaining short fragments of DNA sequences using traditional PCR amplification of DNA has been the primary method for genetic study of historical specimens. Few laboratories have succeeded in obtaining genome-scale sequences from historical specimens and then only with considerable effort and cost. Here, we describe a low-cost approach using high-throughput next-generation sequencing to obtain reliable genome-scale sequence data from a traditionally preserved mammal skin and skull using a simple extraction protocol. We show that single-nucleotide polymorphisms (SNPs) from the genome sequences obtained independently from the skin and from the skull are highly repeatable compared to a reference genome. © 2011 Blackwell Publishing Ltd.

  1. Algorithm of dynamic regulation of a system of duct, for a high accuracy climatic system

    Science.gov (United States)

    Arbatskiy, A. A.; Afonina, G. N.; Glazov, V. S.

    2017-11-01

    Currently, major part of climatic system, are stationary in projected mode only. At the same time, many modern industrial sites, require constant or periodical changes in technological process. That is 80% of the time, the industrial site is not require ventilation system in projected mode and high precision of climatic parameters must maintain. While that not constantly is in use for climatic systems, which use in parallel for different rooms, we will be have a problem for balance of duct system. For this problem, was created the algorithm for quantity regulation, with minimal changes. Dynamic duct system: Developed of parallel control system of air balance, with high precision of climatic parameters. The Algorithm provide a permanent pressure in main duct, in different a flow of air. Therefore, the ending devises air flow have only one parameter for regulation - flaps open area. Precision of regulation increase and the climatic system provide high precision for temperature and humidity (0,5C for temperature, 5% for relative humidity). Result: The research has been made in CFD-system - PHOENICS. Results for velocity of air in duct, for pressure of air in duct for different operation mode, has been obtained. Equation for air valves positions, with different parameters for climate in room’s, has been obtained. Energy saving potential for dynamic duct system, for different types of a rooms, has been calculated.

  2. High-accuracy alignment based on atmospherical dispersion - technological approaches and solutions for the dual-wavelength transmitter

    International Nuclear Information System (INIS)

    Burkhard, Boeckem

    1999-01-01

    In the course of the progressive developments of sophisticated geodetic systems utilizing electromagnetic waves in the visible or near IR-range a more detailed knowledge of the propagation medium and coevally solutions of atmospherically induced limitations will become important. An alignment system based on atmospherical dispersion, called a dispersometer, is a metrological solution to the atmospherically induced limitations, in optical alignment and direction observations of high accuracy. In the dispersometer we are using the dual-wavelength method for dispersive air to obtain refraction compensated angle measurements, the detrimental impact of atmospheric turbulence notwithstanding. The principle of the dual-wavelength method utilizes atmospherical dispersion, i.e. the wavelength dependence of the refractive index. The difference angle between two light beams of different wavelengths, which is called the dispersion angle Δβ, is to first approximation proportional to the refraction angle: β IR ν(β blue - β IR ) = ν Δβ, this equation implies that the dispersion angle has to be measured at least 42 times more accurate than the desired accuracy of the refraction angle for the wavelengths used in the present dispersometer. This required accuracy constitutes one major difficulty for the instrumental performance in applying the dispersion effect. However, the dual-wavelength method can only be successfully used in an optimized transmitter-receiver combination. Beyond the above mentioned resolution requirement for the detector, major difficulties in instrumental realization arise in the availability of a suitable dual-wavelength laser light source, laser light modulation with a very high extinction ratio and coaxial emittance of mono-mode radiation at both wavelengths. Therefore, this paper focuses on the solutions of the dual-wavelength transmitter introducing a new hardware approach and a complete re-design of the in [1] proposed conception of the dual

  3. Study of high energy emissions from stellar mass accreting holes

    International Nuclear Information System (INIS)

    Cadolle-Bel, Marion

    2006-01-01

    The present work is dedicated to the study of various X-ray binary Systems harbouring accreting stellar mass black holes (or candidates) associated in X-ray binary Systems mainly through the spectral and timing properties of the high energy 3 keV"-"1 MeV emission, sometimes completed by observations performed in radio, near-infrared and optical. The first part is devoted to accretion physics phenomena and the challenges of understanding the X-ray/gamma emission produced with the modeling of such high energy processes. Then I will define in a second part the instruments on board INTEGRAL and the way coded masked aperture is employed. In a third part, I will develop the standard data reduction analysis and my own contribution in improving the usual software before detailing the specific informatics tools I have developed for my own analysis. In the fourth part I will turn towards the deep analysis and interpretations I have performed on several black hole X-ray binary Systems chosen properly: the persistent black hole source Cygnus X-1 which has been studied since several years and surprised us by a high-energy excess detected; two new transient sources which provide interesting information, XTE J1720-318 located in the galactic bulge and SWIFT J1753.5-0127, probably situated in the halo. I will also detail my work on H 1743-322, recently identified by INTEGRAL as the HEAO source discovered in 1977, and on three (almost) persistent micro-quasars with superluminal jets, 1E 1740.7-2942, GRS 1758-258 and GRS 1915+105. I will analyze for each source spectral parameter evolutions and their links with each other during state transitions. I will then discuss the presence of two different X/gamma-ray emitting media with a relatively changing geometry. While establishing a cyclic order for the different variability classes of GRS 1915+105 observed during ten years, I will propose an interpretation for such behaviour, compatible with the theoretical predictions of the

  4. Hybrid quadrupole-orbitrap mass spectrometry analysis with accurate-mass database and parallel reaction monitoring for high-throughput screening and quantification of multi-xenobiotics in honey.

    Science.gov (United States)

    Li, Yi; Zhang, Jinzhen; Jin, Yue; Wang, Lin; Zhao, Wen; Zhang, Wenwen; Zhai, Lifei; Zhang, Yaping; Zhang, Yongxin; Zhou, Jinhui

    2016-01-15

    This study reports a rapid, automated screening and quantification method for the determination of multi-xenobiotic residues in honey using ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap) with a user-built accurate-mass database plus parallel reaction monitoring (PRM). The database contains multi-xenobiotic information including formulas, adduct types, theoretical exact mass and retention time, characteristic fragment ions, ion ratios, and mass accuracies. A simple sample preparation method was developed to reduce xenobiotic loss in the honey samples. The screening method was validated based on retention time deviation, mass accuracy via full scan-data-dependent MS/MS (full scan-ddMS2), multi-isotope ratio, characteristic ion ratio, sensitivity, and positive/negative switching performance between the spiked sample and corresponding standard solution. The quantification method based on the PRM mode is a promising new quantitative tool which we validated in terms of selectivity, linearity, recovery (accuracy), repeatability (precision), decision limit (CCα), detection capability (CCβ), matrix effects, and carry-over. The optimized methods proposed in this study enable the automated screening and quantification of 157 compounds in less than 15 min in honey. The results of this study, as they represent a convenient protocol for large-scale screening and quantification, also provide a research approach for analysis of various contaminants in other matrices. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Modelling and Control of Stepper Motors for High Accuracy Positioning Systems Used in Radioactive Environments

    CERN Document Server

    Picatoste Ruilope, Ricardo; Masi, Alessandro

    Hybrid Stepper Motors are widely used in open-loop position applications. They are the choice of actuation for the collimators in the Large Hadron Collider, the largest particle accelerator at CERN. In this case the positioning requirements and the highly radioactive operating environment are unique. The latter forces both the use of long cables to connect the motors to the drives which act as transmission lines and also prevents the use of standard position sensors. However, reliable and precise operation of the collimators is critical for the machine, requiring the prevention of step loss in the motors and maintenance to be foreseen in case of mechanical degradation. In order to make the above possible, an approach is proposed for the application of an Extended Kalman Filter to a sensorless stepper motor drive, when the motor is separated from its drive by long cables. When the long cables and high frequency pulse width modulated control voltage signals are used together, the electrical signals difer greatl...

  6. The study of optimization on process parameters of high-accuracy computerized numerical control polishing

    Science.gov (United States)

    Huang, Wei-Ren; Huang, Shih-Pu; Tsai, Tsung-Yueh; Lin, Yi-Jyun; Yu, Zong-Ru; Kuo, Ching-Hsiang; Hsu, Wei-Yao; Young, Hong-Tsu

    2017-09-01

    Spherical lenses lead to forming spherical aberration and reduced optical performance. Consequently, in practice optical system shall apply a combination of spherical lenses for aberration correction. Thus, the volume of the optical system increased. In modern optical systems, aspherical lenses have been widely used because of their high optical performance with less optical components. However, aspherical surfaces cannot be fabricated by traditional full aperture polishing process due to their varying curvature. Sub-aperture computer numerical control (CNC) polishing is adopted for aspherical surface fabrication in recent years. By using CNC polishing process, mid-spatial frequency (MSF) error is normally accompanied during this process. And the MSF surface texture of optics decreases the optical performance for high precision optical system, especially for short-wavelength applications. Based on a bonnet polishing CNC machine, this study focuses on the relationship between MSF surface texture and CNC polishing parameters, which include feed rate, head speed, track spacing and path direction. The power spectral density (PSD) analysis is used to judge the MSF level caused by those polishing parameters. The test results show that controlling the removal depth of single polishing path, through the feed rate, and without same direction polishing path for higher total removal depth can efficiently reduce the MSF error. To verify the optical polishing parameters, we divided a correction polishing process to several polishing runs with different direction polishing paths. Compare to one shot polishing run, multi-direction path polishing plan could produce better surface quality on the optics.

  7. High accuracy injection circuit for the calibration of a large pixel sensor matrix

    International Nuclear Information System (INIS)

    Quartieri, E.; Comotti, D.; Manghisoni, M.

    2013-01-01

    Semiconductor pixel detectors, for particle tracking and vertexing in high energy physics experiments as well as for X-ray imaging, in particular for synchrotron light sources and XFELs, require a large area sensor matrix. This work will discuss the design and the characterization of a high-linearity, low dispersion injection circuit to be used for pixel-level calibration of detector readout electronics in a large pixel sensor matrix. The circuit provides a useful tool for the characterization of the readout electronics of the pixel cell unit for both monolithic active pixel sensors and hybrid pixel detectors. In the latter case, the circuit allows for precise analogue test of the readout channel already at the chip level, when no sensor is connected. Moreover, it provides a simple means for calibration of readout electronics once the detector has been connected to the chip. Two injection techniques can be provided by the circuit: one for a charge sensitive amplification and the other for a transresistance readout channel. The aim of the paper is to describe the architecture and the design guidelines of the calibration circuit, which has been implemented in a 130 nm CMOS technology. Moreover, experimental results of the proposed injection circuit will be presented in terms of linearity and dispersion

  8. Accuracy of an automated system for tuberculosis detection on chest radiographs in high-risk screening.

    Science.gov (United States)

    Melendez, J; Hogeweg, L; Sánchez, C I; Philipsen, R H H M; Aldridge, R W; Hayward, A C; Abubakar, I; van Ginneken, B; Story, A

    2018-05-01

    Tuberculosis (TB) screening programmes can be optimised by reducing the number of chest radiographs (CXRs) requiring interpretation by human experts. To evaluate the performance of computerised detection software in triaging CXRs in a high-throughput digital mobile TB screening programme. A retrospective evaluation of the software was performed on a database of 38 961 postero-anterior CXRs from unique individuals seen between 2005 and 2010, 87 of whom were diagnosed with TB. The software generated a TB likelihood score for each CXR. This score was compared with a reference standard for notified active pulmonary TB using receiver operating characteristic (ROC) curve and localisation ROC (LROC) curve analyses. On ROC curve analysis, software specificity was 55.71% (95%CI 55.21-56.20) and negative predictive value was 99.98% (95%CI 99.95-99.99), at a sensitivity of 95%. The area under the ROC curve was 0.90 (95%CI 0.86-0.93). Results of the LROC curve analysis were similar. The software could identify more than half of the normal images in a TB screening setting while maintaining high sensitivity, and may therefore be used for triage.

  9. Mass transfer in wetted-wall columns: correlations at high Reynolds numbers

    DEFF Research Database (Denmark)

    Nielsen, Christian H.E.; Kiil, Søren; Thomsen, Henrik W.

    1998-01-01

    (G)) were determined. In dimensionless form, the correlations are given by Sh(L) = 0.01613 Re-G(0.664) Re-L(0.426) Sc-L(0.5) Sh(G) = 0.00031 Re-G(1.05) Re-L(0.207) Sc-G(0.5) and are valid at gas-phase Reynolds numbers from 7500 to 18,300 and liquid-phase Reynolds numbers from 4000 to 12,000, conditions...... of industrial relevance. To our knowledge, no correlations for Sh(G) have been reported in the literature which are valid at such high Reynolds numbers. The wetted-wall column was equipped with six intermediate measuring positions for gas and two for liquid samples, giving rise to a high accuracy...... of the obtained correlations. Our data showed that Sh(L) and Sh(G) both depend on Re-G and Re-L due to changes in the interfacial area at the high Reynolds numbers employed. The presence of inert particles in the liquid-phase may influence the rate of mass transport, and experimental work was initiated to study...

  10. A three axis turntable's online initial state measurement method based on the high-accuracy laser gyro SINS

    Science.gov (United States)

    Gao, Chunfeng; Wei, Guo; Wang, Qi; Xiong, Zhenyu; Wang, Qun; Long, Xingwu

    2016-10-01

    As an indispensable equipment in inertial technology tests, the three-axis turntable is widely used in the calibration of various types inertial navigation systems (INS). In order to ensure the calibration accuracy of INS, we need to accurately measure the initial state of the turntable. However, the traditional measuring method needs a lot of exterior equipment (such as level instrument, north seeker, autocollimator, etc.), and the test processing is complex, low efficiency. Therefore, it is relatively difficult for the inertial measurement equipment manufacturers to realize the self-inspection of the turntable. Owing to the high precision attitude information provided by the laser gyro strapdown inertial navigation system (SINS) after fine alignment, we can use it as the attitude reference of initial state measurement of three-axis turntable. For the principle that the fixed rotation vector increment is not affected by measuring point, we use the laser gyro INS and the encoder of the turntable to provide the attitudes of turntable mounting plat. Through this way, the high accuracy measurement of perpendicularity error and initial attitude of the three-axis turntable has been achieved.

  11. High-accuracy measurement and compensation of grating line-density error in a tiled-grating compressor

    Science.gov (United States)

    Zhao, Dan; Wang, Xiao; Mu, Jie; Li, Zhilin; Zuo, Yanlei; Zhou, Song; Zhou, Kainan; Zeng, Xiaoming; Su, Jingqin; Zhu, Qihua

    2017-02-01

    The grating tiling technology is one of the most effective means to increase the aperture of the gratings. The line-density error (LDE) between sub-gratings will degrade the performance of the tiling gratings, high accuracy measurement and compensation of the LDE are of significance to improve the output pulses characteristics of the tiled-grating compressor. In this paper, the influence of LDE on the output pulses of the tiled-grating compressor is quantitatively analyzed by means of numerical simulation, the output beams drift and output pulses broadening resulting from the LDE are presented. Based on the numerical results we propose a compensation method to reduce the degradations of the tiled grating compressor by applying angular tilt error and longitudinal piston error at the same time. Moreover, a monitoring system is setup to measure the LDE between sub-gratings accurately and the dispersion variation due to the LDE is also demonstrated based on spatial-spectral interference. In this way, we can realize high-accuracy measurement and compensation of the LDE, and this would provide an efficient way to guide the adjustment of the tiling gratings.

  12. High accuracy velocity control method for the french moving-coil watt balance

    International Nuclear Information System (INIS)

    Topcu, Suat; Chassagne, Luc; Haddad, Darine; Alayli, Yasser; Juncar, Patrick

    2004-01-01

    We describe a novel method of velocity control dedicated to the French moving-coil watt balance. In this project, a coil has to move in a magnetic field at a velocity of 2 mm s -1 with a relative uncertainty of 10 -9 over 60 mm. Our method is based on the use of both a heterodyne Michelson's interferometer, a two-level translation stage, and a homemade high frequency phase-shifting electronic circuit. To quantify the stability of the velocity, the output of the interferometer is sent into a frequency counter and the Doppler frequency shift is recorded. The Allan standard deviation has been used to calculate the stability and a σ y (τ) of about 2.2x10 -9 over 400 s has been obtained

  13. Real-time and high accuracy frequency measurements for intermediate frequency narrowband signals

    Science.gov (United States)

    Tian, Jing; Meng, Xiaofeng; Nie, Jing; Lin, Liwei

    2018-01-01

    Real-time and accurate measurements of intermediate frequency signals based on microprocessors are difficult due to the computational complexity and limited time constraints. In this paper, a fast and precise methodology based on the sigma-delta modulator is designed and implemented by first generating the twiddle factors using the designed recursive scheme. This scheme requires zero times of multiplications and only half amounts of addition operations by using the discrete Fourier transform (DFT) and the combination of the Rife algorithm and Fourier coefficient interpolation as compared with conventional methods such as DFT and Fast Fourier Transform. Experimentally, when the sampling frequency is 10 MHz, the real-time frequency measurements with intermediate frequency and narrowband signals have a measurement mean squared error of ±2.4 Hz. Furthermore, a single measurement of the whole system only requires approximately 0.3 s to achieve fast iteration, high precision, and less calculation time.

  14. A high-accuracy image registration algorithm using phase-only correlation for dental radiographs

    International Nuclear Information System (INIS)

    Ito, Koichi; Nikaido, Akira; Aoki, Takafumi; Kosuge, Eiko; Kawamata, Ryota; Kashima, Isamu

    2008-01-01

    Dental radiographs have been used for the accurate assessment and treatment of dental diseases. The nonlinear deformation between two dental radiographs may be observed, even if they are taken from the same oral regions of the subject. For an accurate diagnosis, the complete geometric registration between radiographs is required. This paper presents an efficient dental radiograph registration algorithm using Phase-Only Correlation (POC) function. The use of phase components in 2D (two-dimensional) discrete Fourier transforms of dental radiograph images makes possible to achieve highly robust image registration and recognition. Experimental evaluation using a dental radiograph database indicates that the proposed algorithm exhibits efficient recognition performance even for distorted radiographs. (author)

  15. Combination volumetric and gravimetric sorption instrument for high accuracy measurements of methane adsorption

    Science.gov (United States)

    Burress, Jacob; Bethea, Donald; Troub, Brandon

    2017-05-01

    The accurate measurement of adsorbed gas up to high pressures (˜100 bars) is critical for the development of new materials for adsorbed gas storage. The typical Sievert-type volumetric method introduces accumulating errors that can become large at maximum pressures. Alternatively, gravimetric methods employing microbalances require careful buoyancy corrections. In this paper, we present a combination gravimetric and volumetric system for methane sorption measurements on samples between ˜0.5 and 1 g. The gravimetric method described requires no buoyancy corrections. The tandem use of the gravimetric method allows for a check on the highest uncertainty volumetric measurements. The sources and proper calculation of uncertainties are discussed. Results from methane measurements on activated carbon MSC-30 and metal-organic framework HKUST-1 are compared across methods and within the literature.

  16. Accuracy of W' Recovery Kinetics in High Performance Cyclists - Modelling Intermittent Work Capacity.

    Science.gov (United States)

    Bartram, Jason C; Thewlis, Dominic; Martin, David T; Norton, Kevin I

    2017-10-16

    With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τ W' ) may require refinement to enable effective use in an elite population. Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3.5-6 minutes and featured a range of recovery intensities, set in relation to athlete's CPs (DCP). Using the framework of the SKIBA 2 model, the τ W ' values were modified for each protocol to achieve an accurate W' at volitional exhaustion. Modified τ W ' values were compared to equivalent SKIBA 2 τ W ' values to assess the difference in recovery rates for this population. Plotting modified τ W ' values against DCP showed the adjusted relationship between work-rate and recovery-rate. Comparing modified τ W' values against the SKIBA 2 τ W' values showed a negative bias of 112±46s (mean±95%CL), suggesting athlete's recovered W' faster than predicted by SKIBA 2 (p=0.0001). The modified τ W' to DCP relationship was best described by a power function: τ W' =2287.2∗D CP -0.688 (R 2 = 0.433). The current SKIBA 2 model is not appropriate for use in elite cyclists as it under predicts the recovery rate of W'. The modified τ W' equation presented will require validation, but appears more appropriate for high performance athletes. Individual τ W' relationships may be necessary in order to maximise the model's validity.

  17. Accuracy of Administrative Codes for Distinguishing Positive Pressure Ventilation from High-Flow Nasal Cannula.

    Science.gov (United States)

    Good, Ryan J; Leroue, Matthew K; Czaja, Angela S

    2018-06-07

    Noninvasive positive pressure ventilation (NIPPV) is increasingly used in critically ill pediatric patients, despite limited data on safety and efficacy. Administrative data may be a good resource for observational studies. Therefore, we sought to assess the performance of the International Classification of Diseases, Ninth Revision procedure code for NIPPV. Patients admitted to the PICU requiring NIPPV or heated high-flow nasal cannula (HHFNC) over the 11-month study period were identified from the Virtual PICU System database. The gold standard was manual review of the electronic health record to verify the use of NIPPV or HHFNC among the cohort. The presence or absence of a NIPPV procedure code was determined by using administrative data. Test characteristics with 95% confidence intervals (CIs) were generated, comparing administrative data with the gold standard. Among the cohort ( n = 562), the majority were younger than 5 years, and the most common primary diagnosis was bronchiolitis. Most (82%) required NIPPV, whereas 18% required only HHFNC. The NIPPV code had a sensitivity of 91.1% (95% CI: 88.2%-93.6%) and a specificity of 57.6% (95% CI: 47.2%-67.5%), with a positive likelihood ratio of 2.15 (95% CI: 1.70-2.71) and negative likelihood ratio of 0.15 (95% CI: 0.11-0.22). Among our critically ill pediatric cohort, NIPPV procedure codes had high sensitivity but only moderate specificity. On the basis of our study results, there is a risk of misclassification, specifically failure to identify children who require NIPPV, when using administrative data to study the use of NIPPV in this population. Copyright © 2018 by the American Academy of Pediatrics.

  18. Automatic camera to laser calibration for high accuracy mobile mapping systems using INS

    Science.gov (United States)

    Goeman, Werner; Douterloigne, Koen; Gautama, Sidharta

    2013-09-01

    A mobile mapping system (MMS) is a mobile multi-sensor platform developed by the geoinformation community to support the acquisition of huge amounts of geodata in the form of georeferenced high resolution images and dense laser clouds. Since data fusion and data integration techniques are increasingly able to combine the complementary strengths of different sensor types, the external calibration of a camera to a laser scanner is a common pre-requisite on today's mobile platforms. The methods of calibration, nevertheless, are often relatively poorly documented, are almost always time-consuming, demand expert knowledge and often require a carefully constructed calibration environment. A new methodology is studied and explored to provide a high quality external calibration for a pinhole camera to a laser scanner which is automatic, easy to perform, robust and foolproof. The method presented here, uses a portable, standard ranging pole which needs to be positioned on a known ground control point. For calibration, a well studied absolute orientation problem needs to be solved. In many cases, the camera and laser sensor are calibrated in relation to the INS system. Therefore, the transformation from camera to laser contains the cumulated error of each sensor in relation to the INS. Here, the calibration of the camera is performed in relation to the laser frame using the time synchronization between the sensors for data association. In this study, the use of the inertial relative movement will be explored to collect more useful calibration data. This results in a better intersensor calibration allowing better coloring of the clouds and a more accurate depth mask for images, especially on the edges of objects in the scene.

  19. The Accuracy of Praziquantel Dose Poles for Mass Treatment of Schistosomiasis in School Girls in KwaZulu-Natal, South Africa

    DEFF Research Database (Denmark)

    Baan, Marije; Galappaththi-Arachchige, Hashini Nilushika; Gagai, Silindile

    2016-01-01

    and the recently developed Modified Dose Pole for adults with two additional intervals and correction for body mass index (BMI). Methodology In randomly selected primary and secondary schools of schistosomiasis-endemic areas, height and weight of female pupils were measured. The WHO Tablet Pole and Modified Dose....... Conclusions This study shows that the WHO Tablet Pole will be inaccurate in estimating the dose of praziquantel in South African girls due to high prevalence of overweight/obesity. Under-dosing of individuals who appear overweight/obese could be largely prevented by adding an extra praziquantel tablet...

  20. A continuous flow isotope ratio mass spectrometry method for high precision determination of dissolved gas ratios and isotopic composition

    DEFF Research Database (Denmark)

    Charoenpong, C. N.; Bristow, L. A.; Altabet, M. A.

    2014-01-01

    ratio mass spectrometer (IRMS). A continuous flow of He carrier gas completely degasses the sample, and passes through the preparation and purification system before entering the IRMS for analysis. The use of this continuous He carrier permits short analysis times (less than 8 min per sample......) as compared with current high-precision methods. In addition to reference gases, calibration is achieved using air-equilibrated water standards of known temperature and salinity. Assessment of reference gas injections, air equilibrated standards, as well as samples collected in the field shows the accuracy...

  1. Analysis of high accuracy, quantitative proteomics data in the MaxQB database.

    Science.gov (United States)

    Schaab, Christoph; Geiger, Tamar; Stoehr, Gabriele; Cox, Juergen; Mann, Matthias

    2012-03-01

    MS-based proteomics generates rapidly increasing amounts of precise and quantitative information. Analysis of individual proteomic experiments has made great strides, but the crucial ability to compare and store information across different proteome measurements still presents many challenges. For example, it has been difficult to avoid contamination of databases with low quality peptide identifications, to control for the inflation in false positive identifications when combining data sets, and to integrate quantitative data. Although, for example, the contamination with low quality identifications has been addressed by joint analysis of deposited raw data in some public repositories, we reasoned that there should be a role for a database specifically designed for high resolution and quantitative data. Here we describe a novel database termed MaxQB that stores and displays collections of large proteomics projects and allows joint analysis and comparison. We demonstrate the analysis tools of MaxQB using proteome data of 11 different human cell lines and 28 mouse tissues. The database-wide false discovery rate is controlled by adjusting the project specific cutoff scores for the combined data sets. The 11 cell line proteomes together identify proteins expressed from more than half of all human genes. For each protein of interest, expression levels estimated by label-free quantification can be visualized across the cell lines. Similarly, the expression rank order and estimated amount of each protein within each proteome are plotted. We used MaxQB to calculate the signal reproducibility of the detected peptides for the same proteins across different proteomes. Spearman rank correlation between peptide intensity and detection probability of identified proteins was greater than 0.8 for 64% of the proteome, whereas a minority of proteins have negative correlation. This information can be used to pinpoint false protein identifications, independently of peptide database

  2. CO outflows from high-mass Class 0 protostars in Cygnus-X

    Science.gov (United States)

    Duarte-Cabral, A.; Bontemps, S.; Motte, F.; Hennemann, M.; Schneider, N.; André, Ph.

    2013-10-01

    Context. The earliest phases of the formation of high-mass stars are not well known. It is unclear whether high-mass cores in monolithic collapse exist or not, and what the accretion process and origin of the material feeding the precursors of high-mass stars are. As outflows are natural consequences of the accretion process, they represent one of the few (indirect) tracers of accretion. Aims: We aim to search for individual outflows from high-mass cores in Cygnus X and to study the characteristics of the detected ejections. We compare these to what has been found for the low-mass protostars, to understand how ejection and accretion change and behave with final stellar mass. Methods: We used CO (2-1) PdBI observations towards six massive dense clumps, containing a total of 9 high-mass cores. We estimated the bolometric luminosities and masses of the 9 high-mass cores and measured the energetics of outflows. We compared our sample to low-mass objects studied in the literature and developed simple evolutionary models to reproduce the observables. Results: We find that 8 out of 9 high-mass cores are driving clear individual outflows. They are therefore true equivalents of Class 0 protostars in the high-mass regime. The remaining core, CygX-N53 MM2, has only a tentative outflow detection. It could be one of the first examples of a true individual high-mass prestellar core. We also find that the momentum flux of high-mass objects has a linear relation to the reservoir of mass in the envelope, as a scale up of the relations previously found for low-mass protostars. This suggests a fundamental proportionality between accretion rates and envelope masses. The linear dependency implies that the timescale for accretion is similar for high- and low-mass stars. Conclusions: The existence of strong outflows driven by high-mass cores in Cygnus X clearly indicates that high-mass Class 0 protostars exist. The collapsing envelopes of these Class 0 objects have similar sizes and a

  3. Determination of the QCD Λ-parameter and the accuracy of perturbation theory at high energies

    International Nuclear Information System (INIS)

    Dalla Brida, Mattia; Fritzsch, Patrick; Korzec, Tomasz; Ramos, Alberto; Sint, Stefan; Sommer, Rainer; Humboldt-Universitaet, Berlin

    2016-04-01

    We discuss the determination of the strong coupling α_M_S(m_Z) or equivalently the QCD Λ-parameter. Its determination requires the use of perturbation theory in α_s(μ) in some scheme, s, and at some energy scale μ. The higher the scale μ the more accurate perturbation theory becomes, owing to asymptotic freedom. As one step in our computation of the Λ-parameter in three-flavor QCD, we perform lattice computations in a scheme which allows us to non-perturbatively reach very high energies, corresponding to α_s=0.1 and below. We find that (continuum) perturbation theory is very accurate there, yielding a three percent error in the Λ-parameter, while data around α_s∼0.2 is clearly insufficient to quote such a precision. It is important to realize that these findings are expected to be generic, as our scheme has advantageous properties regarding the applicability of perturbation theory.

  4. Determination of the QCD Λ-parameter and the accuracy of perturbation theory at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Dalla Brida, Mattia [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Fritzsch, Patrick [Univ. Autonoma de Madrid (Spain). Inst. de Fisica Teorica UAM/CSIC; Korzec, Tomasz [Wuppertal Univ. (Germany). Dept. of Physics; Ramos, Alberto [CERN - European Organization for Nuclear Research, Geneva (Switzerland). Theory Div.; Sint, Stefan [Trinity College Dublin (Ireland). School of Mathematics; Sommer, Rainer [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Collaboration: ALPHA Collaboration

    2016-04-15

    We discuss the determination of the strong coupling α{sub MS}(m{sub Z}) or equivalently the QCD Λ-parameter. Its determination requires the use of perturbation theory in α{sub s}(μ) in some scheme, s, and at some energy scale μ. The higher the scale μ the more accurate perturbation theory becomes, owing to asymptotic freedom. As one step in our computation of the Λ-parameter in three-flavor QCD, we perform lattice computations in a scheme which allows us to non-perturbatively reach very high energies, corresponding to α{sub s}=0.1 and below. We find that (continuum) perturbation theory is very accurate there, yielding a three percent error in the Λ-parameter, while data around α{sub s}∼0.2 is clearly insufficient to quote such a precision. It is important to realize that these findings are expected to be generic, as our scheme has advantageous properties regarding the applicability of perturbation theory.

  5. High-accuracy X-ray detector calibration based on cryogenic radiometry

    Science.gov (United States)

    Krumrey, M.; Cibik, L.; Müller, P.

    2010-06-01

    Cryogenic electrical substitution radiometers (ESRs) are absolute thermal detectors, based on the equivalence of electrical power and radiant power. Their core piece is a cavity absorber, which is typically made of copper to achieve a short response time. At higher photon energies, the use of copper prevents the operation of ESRs due to increasing transmittance. A new absorber design for hard X-rays has been developed at the laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the electron storage ring BESSY II. The Monte Carlo simulation code Geant4 was applied to optimize its absorptance for photon energies of up to 60 keV. The measurement of the radiant power of monochromatized synchrotron radiation was achieved with relative standard uncertainties of less than 0.2 %, covering the entire photon energy range of three beamlines from 50 eV to 60 keV. Monochromatized synchrotron radiation of high spectral purity is used to calibrate silicon photodiodes against the ESR for photon energies up to 60 keV with relative standard uncertainties below 0.3 %. For some silicon photodiodes, the photocurrent is not linear with the incident radiant power.

  6. High-accuracy X-ray detector calibration based on cryogenic radiometry

    International Nuclear Information System (INIS)

    Krumrey, M.; Cibik, L.; Mueller, P.

    2010-01-01

    Cryogenic electrical substitution radiometers (ESRs) are absolute thermal detectors, based on the equivalence of electrical power and radiant power. Their core piece is a cavity absorber, which is typically made of copper to achieve a short response time. At higher photon energies, the use of copper prevents the operation of ESRs due to increasing transmittance. A new absorber design for hard X-rays has been developed at the laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the electron storage ring BESSY II. The Monte Carlo simulation code Geant4 was applied to optimize its absorptance for photon energies of up to 60 keV. The measurement of the radiant power of monochromatized synchrotron radiation was achieved with relative standard uncertainties of less than 0.2 %, covering the entire photon energy range of three beamlines from 50 eV to 60 keV. Monochromatized synchrotron radiation of high spectral purity is used to calibrate silicon photodiodes against the ESR for photon energies up to 60 keV with relative standard uncertainties below 0.3 %. For some silicon photodiodes, the photocurrent is not linear with the incident radiant power.

  7. High-accuracy local positioning network for the alignment of the Mu2e experiment.

    Energy Technology Data Exchange (ETDEWEB)

    Hejdukova, Jana B. [Czech Technical Univ., Prague (Czech Republic)

    2017-06-01

    This Diploma thesis describes the establishment of a high-precision local positioning network and accelerator alignment for the Mu2e physics experiment. The process of establishing new network consists of few steps: design of the network, pre-analysis, installation works, measurements of the network and making adjustments. Adjustments were performed using two approaches. First is a geodetic approach of taking into account the Earth’s curvature and the metrological approach of a pure 3D Cartesian system on the other side. The comparison of those two approaches is performed and evaluated in the results and compared with expected differences. The effect of the Earth’s curvature was found to be significant for this kind of network and should not be neglected. The measurements were obtained with Absolute Tracker AT401, leveling instrument Leica DNA03 and gyrotheodolite DMT Gyromat 2000. The coordinates of the points of the reference network were determined by the Least Square Meth od and the overall view is attached as Annexes.

  8. Diagnostic accuracy for X-ray chest in interstitial lung disease as confirmed by high resolution computed tomography (HRCT) chest

    International Nuclear Information System (INIS)

    Afzal, F.; Raza, S.; Shafique, M.

    2017-01-01

    Objective: To determine the diagnostic accuracy of x-ray chest in interstitial lung disease as confirmed by high resolution computed tomography (HRCT) chest. Study Design: A cross-sectional validational study. Place and Duration of Study: Department of Diagnostic Radiology, Combined Military Hospital Rawalpindi, from Oct 2013 to Apr 2014. Material and Method: A total of 137 patients with clinical suspicion of interstitial lung disease (ILD) aged 20-50 years of both genders were included in the study. Patients with h/o previous histopathological diagnosis, already taking treatment and pregnant females were excluded. All the patients had chest x-ray and then HRCT. The x-ray and HRCT findings were recorded as presence or absence of the ILD. Results: Mean age was 40.21 ± 4.29 years. Out of 137 patients, 79 (57.66 percent) were males and 58 (42.34 percent) were females with male to female ratio of 1.36:1. Chest x-ray detected ILD in 80 (58.39 percent) patients, out of which, 72 (true positive) had ILD and 8 (false positive) had no ILD on HRCT. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of chest x-ray in diagnosing ILD was 80.0 percent, 82.98 percent, 90.0 percent, 68.42 percent and 81.02 percent respectively. Conclusion: This study concluded that chest x-ray is simple, non-invasive, economical and readily available alternative to HRCT with an acceptable diagnostic accuracy of 81 percent in the diagnosis of ILD. (author)

  9. Social power and recognition of emotional prosody: High power is associated with lower recognition accuracy than low power.

    Science.gov (United States)

    Uskul, Ayse K; Paulmann, Silke; Weick, Mario

    2016-02-01

    Listeners have to pay close attention to a speaker's tone of voice (prosody) during daily conversations. This is particularly important when trying to infer the emotional state of the speaker. Although a growing body of research has explored how emotions are processed from speech in general, little is known about how psychosocial factors such as social power can shape the perception of vocal emotional attributes. Thus, the present studies explored how social power affects emotional prosody recognition. In a correlational study (Study 1) and an experimental study (Study 2), we show that high power is associated with lower accuracy in emotional prosody recognition than low power. These results, for the first time, suggest that individuals experiencing high or low power perceive emotional tone of voice differently. (c) 2016 APA, all rights reserved).

  10. Improved accuracy and precision in δ15 NAIR measurements of explosives, urea, and inorganic nitrates by elemental analyzer/isotope ratio mass spectrometry using thermal decomposition.

    Science.gov (United States)

    Lott, Michael J; Howa, John D; Chesson, Lesley A; Ehleringer, James R

    2015-08-15

    Elemental analyzer systems generate N(2) and CO(2) for elemental composition and isotope ratio measurements. As quantitative conversion of nitrogen in some materials (i.e., nitrate salts and nitro-organic compounds) is difficult, this study tests a recently published method - thermal decomposition without the addition of O(2) - for the analysis of these materials. Elemental analyzer/isotope ratio mass spectrometry (EA/IRMS) was used to compare the traditional combustion method (CM) and the thermal decomposition method (TDM), where additional O(2) is eliminated from the reaction. The comparisons used organic and inorganic materials with oxidized and/or reduced nitrogen and included ureas, nitrate salts, ammonium sulfate, nitro esters, and nitramines. Previous TDM applications were limited to nitrate salts and ammonium sulfate. The measurement precision and accuracy were compared to determine the effectiveness of converting materials containing different fractions of oxidized nitrogen into N(2). The δ(13) C(VPDB) values were not meaningfully different when measured via CM or TDM, allowing for the analysis of multiple elements in one sample. For materials containing oxidized nitrogen, (15) N measurements made using thermal decomposition were more precise than those made using combustion. The precision was similar between the methods for materials containing reduced nitrogen. The %N values were closer to theoretical when measured by TDM than by CM. The δ(15) N(AIR) values of purchased nitrate salts and ureas were nearer to the known values when analyzed using thermal decomposition than using combustion. The thermal decomposition method addresses insufficient recovery of nitrogen during elemental analysis in a variety of organic and inorganic materials. Its implementation requires relatively few changes to the elemental analyzer. Using TDM, it is possible to directly calibrate certain organic materials to international nitrate isotope reference materials without off

  11. High-accuracy detection of early Parkinson's Disease using multiple characteristics of finger movement while typing.

    Directory of Open Access Journals (Sweden)

    Warwick R Adams

    Full Text Available Parkinson's Disease (PD is a progressive neurodegenerative movement disease affecting over 6 million people worldwide. Loss of dopamine-producing neurons results in a range of both motor and non-motor symptoms, however there is currently no definitive test for PD by non-specialist clinicians, especially in the early disease stages where the symptoms may be subtle and poorly characterised. This results in a high misdiagnosis rate (up to 25% by non-specialists and people can have the disease for many years before diagnosis. There is a need for a more accurate, objective means of early detection, ideally one which can be used by individuals in their home setting. In this investigation, keystroke timing information from 103 subjects (comprising 32 with mild PD severity and the remainder non-PD controls was captured as they typed on a computer keyboard over an extended period and showed that PD affects various characteristics of hand and finger movement and that these can be detected. A novel methodology was used to classify the subjects' disease status, by utilising a combination of many keystroke features which were analysed by an ensemble of machine learning classification models. When applied to two separate participant groups, this approach was able to successfully discriminate between early-PD subjects and controls with 96% sensitivity, 97% specificity and an AUC of 0.98. The technique does not require any specialised equipment or medical supervision, and does not rely on the experience and skill of the practitioner. Regarding more general application, it currently does not incorporate a second cardinal disease symptom, so may not differentiate PD from similar movement-related disorders.

  12. Search for a high mass diphoton resonance using the ATLAS detector

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00104125; The ATLAS collaboration

    2017-01-01

    High-mass states decaying into two photons are predicted in many extensions of the Standard Model (SM). The diphoton final state provides a clean experimental signature with good invariant mass resolution and moderate backgrounds. Searches for high-mass resonances decaying into two photons for a spin-0 or spin-2 state are presented. The latest ATLAS results using p-p collision data at 13 TeV and covering a large mass range are discussed.

  13. Mass analyzer ``MASHA'' high temperature target and plasma ion source

    Science.gov (United States)

    Semchenkov, A. G.; Rassadov, D. N.; Bekhterev, V. V.; Bystrov, V. A.; Chizov, A. Yu.; Dmitriev, S. N.; Efremov, A. A.; Guljaev, A. V.; Kozulin, E. M.; Oganessian, Yu. Ts.; Starodub, G. Ya.; Voskresensky, V. M.; Bogomolov, S. L.; Paschenko, S. V.; Zelenak, A.; Tikhonov, V. I.

    2004-05-01

    A new separator and mass analyzer of super heavy atoms (MASHA) has been created at the FLNR JINR Dubna to separate and measure masses of nuclei and molecules with precision better than 10-3. First experiments with the FEBIAD plasma ion source have been done and give an efficiency of ionization of up to 20% for Kr with a low flow test leak (6 particle μA). We suppose a magnetic field optimization, using the additional electrode (einzel lens type) in the extracting system, and an improving of the vacuum conditions in order to increase the ion source efficiency.

  14. Mass analyzer 'MASHA' high temperature target and plasma ion source

    International Nuclear Information System (INIS)

    Semchenkov, A.G.; Rassadov, D.N.; Bekhterev, V.V.; Bystrov, V.A.; Chizov, A.Yu.; Dmitriev, S.N.; Efremov, A.A.; Guljaev, A.V.; Kozulin, E.M.; Oganessian, Yu.Ts.; Starodub, G.Ya.; Voskresensky, V.M.; Bogomolov, S.L.; Paschenko, S.V.; Zelenak, A.; Tikhonov, V.I.

    2004-01-01

    A new separator and mass analyzer of super heavy atoms (MASHA) has been created at the FLNR JINR Dubna to separate and measure masses of nuclei and molecules with precision better than 10 -3 . First experiments with the FEBIAD plasma ion source have been done and give an efficiency of ionization of up to 20% for Kr with a low flow test leak (6 particle μA). We suppose a magnetic field optimization, using the additional electrode (einzel lens type) in the extracting system, and an improving of the vacuum conditions in order to increase the ion source efficiency

  15. High Mass Standard Model Higgs searches at the Tevatron

    Directory of Open Access Journals (Sweden)

    Petridis Konstantinos A.

    2012-06-01

    Full Text Available We present the results of searches for the Standard Model Higgs boson decaying predominantly to W+W− pairs, at a center-of-mass energy of √s = 1.96 TeV, using up to 8.2 fb−1 of data collected with the CDF and D0 detectors at the Fermilab Tevatron collider. The analysis techniques and the various channels considered are discussed. These searches result in exclusions across the Higgs mass range of 156.5< mH <173.7 GeV for CDF and 161< mH <170 GeV for D0.

  16. A diabetes dashboard and physician efficiency and accuracy in accessing data needed for high-quality diabetes care.

    Science.gov (United States)

    Koopman, Richelle J; Kochendorfer, Karl M; Moore, Joi L; Mehr, David R; Wakefield, Douglas S; Yadamsuren, Borchuluun; Coberly, Jared S; Kruse, Robin L; Wakefield, Bonnie J; Belden, Jeffery L

    2011-01-01

    We compared use of a new diabetes dashboard screen with use of a conventional approach of viewing multiple electronic health record (EHR) screens to find data needed for ambulatory diabetes care. We performed a usability study, including a quantitative time study and qualitative analysis of information-seeking behaviors. While being recorded with Morae Recorder software and "think-aloud" interview methods, 10 primary care physicians first searched their EHR for 10 diabetes data elements using a conventional approach for a simulated patient, and then using a new diabetes dashboard for another. We measured time, number of mouse clicks, and accuracy. Two coders analyzed think-aloud and interview data using grounded theory methodology. The mean time needed to find all data elements was 5.5 minutes using the conventional approach vs 1.3 minutes using the diabetes dashboard (P dashboard (P dashboard (P dashboard improves both the efficiency and accuracy of acquiring data needed for high-quality diabetes care. Usability analysis tools can provide important insights into the value of optimizing physician use of health information technologies.

  17. High-accuracy self-calibration method for dual-axis rotation-modulating RLG-INS

    Science.gov (United States)

    Wei, Guo; Gao, Chunfeng; Wang, Qi; Wang, Qun; Long, Xingwu

    2017-05-01

    Inertial navigation system has been the core component of both military and civil navigation systems. Dual-axis rotation modulation can completely eliminate the inertial elements constant errors of the three axes to improve the system accuracy. But the error caused by the misalignment angles and the scale factor error cannot be eliminated through dual-axis rotation modulation. And discrete calibration method cannot fulfill requirements of high-accurate calibration of the mechanically dithered ring laser gyroscope navigation system with shock absorbers. This paper has analyzed the effect of calibration error during one modulated period and presented a new systematic self-calibration method for dual-axis rotation-modulating RLG-INS. Procedure for self-calibration of dual-axis rotation-modulating RLG-INS has been designed. The results of self-calibration simulation experiment proved that: this scheme can estimate all the errors in the calibration error model, the calibration precision of the inertial sensors scale factor error is less than 1ppm and the misalignment is less than 5″. These results have validated the systematic self-calibration method and proved its importance for accuracy improvement of dual -axis rotation inertial navigation system with mechanically dithered ring laser gyroscope.

  18. Shock tube/time-of-flight mass spectrometer for high temperature kinetic studies

    International Nuclear Information System (INIS)

    Tranter, Robert S.; Giri, Binod R.; Kiefer, John H.

    2007-01-01

    A shock tube (ST) with online, time-of-flight mass spectrometric (TOF-MS) detection has been constructed for the study of elementary reactions at high temperature. The ST and TOF-MS are coupled by a differentially pumped molecular beam sampling interface, which ensures that the samples entering the TOF-MS are not contaminated by gases drawn from the cold end wall thermal boundary layer in the ST. Additionally, the interface allows a large range of postshock pressures to be used in the shock tube while maintaining high vacuum in the TOF-MS. The apparatus and the details of the sampling system are described along with an analysis in which cooling of the sampled gases and minimization of thermal boundary layer effects are discussed. The accuracy of kinetic measurements made with the apparatus has been tested by investigating the thermal unimolecular dissociation of cyclohexene to ethylene and 1,3-butadiene, a well characterized reaction for which considerable literature data that are in good agreement exist. The experiments were performed at nominal reflected shock wave pressures of 600 and 1300 Torr, and temperatures ranging from 1260 to 1430 K. The rate coefficients obtained are compared with the earlier shock tube studies and are found to be in very good agreement. As expected no significant difference is observed in the rate constant between pressures of 600 and 1300 Torr

  19. Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Andrew N., E-mail: anlane01@louisville.edu [JG Brown Cancer Center, 529 S. Jackson Street, Louisville, KY 40202 (United States); Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY (United States); Fan, Teresa W.-M. [JG Brown Cancer Center, 529 S. Jackson Street, Louisville, KY 40202 (United States); Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY (United States); Department of Chemistry, University of Louisville, Louisville, KY 40292 (United States); Xie, Zhengzhi; Moseley, Hunter N.B.; Higashi, Richard M. [Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY (United States); Department of Chemistry, University of Louisville, Louisville, KY 40292 (United States)

    2009-10-05

    We have coupled 2D-NMR and infusion FT-ICR-MS with computer-assisted assignment to profile {sup 13}C-isotopologues of glycerophospholipids (GPL) directly in crude cell extracts, resulting in very high information throughput of >3000 isobaric molecules in a few minutes. A mass accuracy of better than 1 ppm combined with a resolution of 100,000 at the measured m/z was required to distinguish isotopomers from other GPL structures. Isotopologue analysis of GPLs extracted from LCC2 breast cancer cells grown on [U-{sup 13}C]-glucose provided a rich trove of information about the biosynthesis and turnover of the GPLs. The isotopologue intensity ratios from the FT-ICR-MS were accurate to {approx}1% or better based on natural abundance background, and depended on the signal-to-nose ratio. The time course of incorporation of {sup 13}C from [U-{sup 13}C]-glucose into a particular phosphatidylcholine was analyzed in detail, to provide a quantitative measure of the sizes of glycerol, acetyl CoA and total GPL pools in growing LCC2 cells. Independent and complementary analysis of the positional {sup 13}C enrichment in the glycerol and fatty acyl chains obtained from high resolution 2D NMR was used to verify key aspects of the model. This technology enables simple and rapid sample preparation, has rapid analysis, and is generally applicable to unfractionated GPLs of almost any head group, and to mixtures of other classes of metabolites.

  20. Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR

    International Nuclear Information System (INIS)

    Lane, Andrew N.; Fan, Teresa W.-M.; Xie, Zhengzhi; Moseley, Hunter N.B.; Higashi, Richard M.

    2009-01-01

    We have coupled 2D-NMR and infusion FT-ICR-MS with computer-assisted assignment to profile 13 C-isotopologues of glycerophospholipids (GPL) directly in crude cell extracts, resulting in very high information throughput of >3000 isobaric molecules in a few minutes. A mass accuracy of better than 1 ppm combined with a resolution of 100,000 at the measured m/z was required to distinguish isotopomers from other GPL structures. Isotopologue analysis of GPLs extracted from LCC2 breast cancer cells grown on [U- 13 C]-glucose provided a rich trove of information about the biosynthesis and turnover of the GPLs. The isotopologue intensity ratios from the FT-ICR-MS were accurate to ∼1% or better based on natural abundance background, and depended on the signal-to-nose ratio. The time course of incorporation of 13 C from [U- 13 C]-glucose into a particular phosphatidylcholine was analyzed in detail, to provide a quantitative measure of the sizes of glycerol, acetyl CoA and total GPL pools in growing LCC2 cells. Independent and complementary analysis of the positional 13 C enrichment in the glycerol and fatty acyl chains obtained from high resolution 2D NMR was used to verify key aspects of the model. This technology enables simple and rapid sample preparation, has rapid analysis, and is generally applicable to unfractionated GPLs of almost any head group, and to mixtures of other classes of metabolites.

  1. Location accuracy evaluation of lightning location systems using natural lightning flashes recorded by a network of high-speed cameras

    Science.gov (United States)

    Alves, J.; Saraiva, A. C. V.; Campos, L. Z. D. S.; Pinto, O., Jr.; Antunes, L.

    2014-12-01

    This work presents a method for the evaluation of location accuracy of all Lightning Location System (LLS) in operation in southeastern Brazil, using natural cloud-to-ground (CG) lightning flashes. This can be done through a multiple high-speed cameras network (RAMMER network) installed in the Paraiba Valley region - SP - Brazil. The RAMMER network (Automated Multi-camera Network for Monitoring and Study of Lightning) is composed by four high-speed cameras operating at 2,500 frames per second. Three stationary black-and-white (B&W) cameras were situated in the cities of São José dos Campos and Caçapava. A fourth color camera was mobile (installed in a car), but operated in a fixed location during the observation period, within the city of São José dos Campos. The average distance among cameras was 13 kilometers. Each RAMMER sensor position was determined so that the network can observe the same lightning flash from different angles and all recorded videos were GPS (Global Position System) time stamped, allowing comparisons of events between cameras and the LLS. The RAMMER sensor is basically composed by a computer, a Phantom high-speed camera version 9.1 and a GPS unit. The lightning cases analyzed in the present work were observed by at least two cameras, their position was visually triangulated and the results compared with BrasilDAT network, during the summer seasons of 2011/2012 and 2012/2013. The visual triangulation method is presented in details. The calibration procedure showed an accuracy of 9 meters between the accurate GPS position of the object triangulated and the result from the visual triangulation method. Lightning return stroke positions, estimated with the visual triangulation method, were compared with LLS locations. Differences between solutions were not greater than 1.8 km.

  2. Study of High Mass Electron Pairs and High pT Phenomena

    CERN Multimedia

    2002-01-01

    This experiment involves a modification of the apparatus used in R108, which extends the region of photon and electron detection to the entire azimuth, complementing the full azimuth charged particle detection already available. A five-fold increase in the acceptance for high mass e|+e|- pairs is thus achieved; the study of jets is also improved by extending the region of @g and @p|0 detection. An active converter consisting of lead glass and followed by a cathode strip read out MWPC is placed in front of each of the R108 lead glass arrays to improve @g/@p|0 discrimination. The modified apparatus is shown in the Figure. The specific physics aims of the experiment are: \\item 1) Search for high mass states decaying into e|+e|-. In a 3000-hour run the sensitivity is 2\\% of the @U cross-section for 10 detected events. \\item 2) Study of e|+e|- pair production above the @U mass. As well as the cross-section, the transverse momentum and rapidity distributions will be measured, providing a crucial test of QCD as appl...

  3. Nuclear reactions of high energy deuterons with medium mass targets

    International Nuclear Information System (INIS)

    Numajiri, Masaharu; Miura, Taichi; Oki, Yuichi

    1994-01-01

    Formation cross sections of product nuclides in the nuclear reactions of medium mass targets by 10 GeV deuterons were measured with a gamma-ray spectroscopy. The measured data were compared with the cross sections of 12 GeV protons. (author)

  4. High frequency body mass measurement, feedback, and health behaviors

    NARCIS (Netherlands)

    Kooreman, P.; Scherpenzeel, A.

    We analyze weight and fat percentage measurements of respondents in an online general population panel in the Netherlands, collected using wireless scales, with an average frequency of 1.6 measurements per week. First, we document the existence of a weekly cycle; body mass is lowest on Fridays and

  5. Assessment of high precision, high accuracy Inductively Coupled Plasma-Optical Emission Spectroscopy to obtain concentration uncertainties less than 0.2% with variable matrix concentrations

    International Nuclear Information System (INIS)

    Rabb, Savelas A.; Olesik, John W.

    2008-01-01

    The ability to obtain high precision, high accuracy measurements in samples with complex matrices using High Performance Inductively Coupled Plasma-Optical Emission Spectroscopy (HP-ICP-OES) was investigated. The Common Analyte Internal Standard (CAIS) procedure was incorporated into the High Performance Inductively Coupled Plasma-Optical Emission Spectroscopy method to correct for matrix-induced changes in emission intensity ratios. Matrix matching and standard addition approaches to minimize matrix-induced errors when using High Performance Inductively Coupled Plasma-Optical Emission Spectroscopy were also assessed. The High Performance Inductively Coupled Plasma-Optical Emission Spectroscopy method was tested with synthetic solutions in a variety of matrices, alloy standard reference materials and geological reference materials

  6. The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast

    Science.gov (United States)

    Li, Yongkai; Yi, Ming; Zou, Xiufen

    2014-01-01

    To gain insights into the mechanisms of cell fate decision in a noisy environment, the effects of intrinsic and extrinsic noises on cell fate are explored at the single cell level. Specifically, we theoretically define the impulse of Cln1/2 as an indication of cell fates. The strong dependence between the impulse of Cln1/2 and cell fates is exhibited. Based on the simulation results, we illustrate that increasing intrinsic fluctuations causes the parallel shift of the separation ratio of Whi5P but that increasing extrinsic fluctuations leads to the mixture of different cell fates. Our quantitative study also suggests that the strengths of intrinsic and extrinsic noises around an approximate linear model can ensure a high accuracy of cell fate selection. Furthermore, this study demonstrates that the selection of cell fates is an entropy-decreasing process. In addition, we reveal that cell fates are significantly correlated with the range of entropy decreases. PMID:25042292

  7. A direct indication of plasma potential diagnostic with fast time response and high accuracy based on a differential emissive probe

    International Nuclear Information System (INIS)

    Yao, W.E.; Hershkowitz; Intrator, T.

    1985-01-01

    The floating potential of the emissive probe has been used to directly measure the plasma potential. The authors have recently presented another method for directly indicating the plasma potential with a differential emissive probe. In this paper they describe the effects of probe size, plasma density and plasma potential fluctuation on plasma potential measurements and give methods for reducing errors. A control system with fast time response (α 20 μs) and high accuracy (the order of the probe temperature T/sub w//e) for maintaining a differential emissive probe at plasma potential has been developed. It can be operated in pulsed discharge plasma to measure plasma potential dynamic characteristics. A solid state optical coupler is employed to improve circuit performance. This system was tested experimentally by measuring the plasma potential in an argon plasma device an on the Phaedrus tandem mirror

  8. A high-accuracy extraction of the isoscalar πN scattering length from pionic deuterium data

    International Nuclear Information System (INIS)

    Phillips, Daniel R.; Baru, Vadim; Hanhart, Christoph; Nogga, Andreas; Hoferichter, Martin; Kubis, Bastian

    2010-01-01

    We present a high-accuracy calculation of the π(bar sign)d scattering length using chiral perturbation theory up to order (M π /m p ) 7/2 . For the first time isospin-violating corrections are included consistently. The resulting value of a π -bar d has a theoretical uncertainty of a few percent. We use it, together with data on pionic deuterium and pionic hydrogen atoms, to extract the isoscalar and isovector pion-nucleon scattering lengths from a combined analysis, and obtain a + (7.9±3.2)·10 -3 M π -1 and a-bar (86.3±1.0)·10 -3 M π -1 .

  9. A direct indication of plasma potential diagnostic with fast time response and high accuracy based on a differential emissive probe

    International Nuclear Information System (INIS)

    Yao, W.E.; Hershkowitz, N.; Intrator, T.

    1985-01-01

    The floating potential of the emissive probe has been used to directly measure the plasma potential. The authors have recently presented another method for directly indicating the plasma potential with a differential emissive probe. In this paper they describe the effects of probe size, plasma density and plasma potential fluctuation on plasma potential measurements and give methods for reducing errors. A control system with fast time response (≅ 20 μs) and high accuracy (the order of the probe temperature T/sub w//e) for maintaining a differential emissive probe at plasma potential has been developed. It can be operated in pulsed discharge plasma to measure plasma potential dynamic characteristics. A solid state optical coupler is employed to improve circuit performance. This system was tested experimentally by measuring the plasma potential in an argon plasma device and on the Phaedrus tandem mirror

  10. Image quality, radiation dose, and diagnostic accuracy of prospectively ECG-triggered high-pitch coronary CT angiography at 70 kVp in a clinical setting: comparison with invasive coronary angiography

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Long Jiang; Qi, Li; Zhou, Chang Sheng; Zhao, Yan E.; Li, Xie; Lu, Guang Ming [Jinling Hospital, Medical School of Nanjing University, Department of Medical Imaging, Nanjing, Jiangsu (China); Wang, Yining; Cao, Jian; Jin, Zhengyu [Peking Union Medical College Hospital, Department of Radiology, Beijing (China); Schoepf, U.J. [Jinling Hospital, Medical School of Nanjing University, Department of Medical Imaging, Nanjing, Jiangsu (China); Medical University of South Carolina, Division of Cardiovascular Imaging, Charleston, SC (United States); Meinel, Felix G. [Medical University of South Carolina, Division of Cardiovascular Imaging, Charleston, SC (United States); Ludwig-Maximilians-University Hospital, Institute for Clinical Radiology, Munich (Germany); Bayer, Richard R. [Medical University of South Carolina, Division of Cardiovascular Imaging, Charleston, SC (United States); Gong, Jian Bin [Jinling Hospital, Medical School of Nanjing University, Department of Cardiology, Nanjing, Jiangsu (China)

    2016-03-15

    To investigate image quality, radiation dose, and diagnostic performance of prospectively ECG-triggered high-pitch coronary CT angiography (CCTA) at 70 kVp compared to invasive coronary angiography (ICA) as reference standard. Forty-three patients underwent prospectively ECG-triggered high-pitch CCTA at 70 kVp using 30 cc (11 g iodine) contrast medium and ICA. Subjective and objective image quality was evaluated for each CCTA study. CCTA performance for diagnosing ≥50 % stenosis was assessed. Results were stratified according to heart rate (HR), body mass index (BMI), Agatston score, and image quality. At CCTA, 94.3 % (500/530) of coronary segments were of diagnostic quality. Using ICA as reference standard, sensitivity and accuracy were 100 % and 93.0 % on a per-patient basis. Per-vessel and per-segment performances were 92.2 % and 89.5 %; 79.5 % and 88.3 %, respectively. No differences were found in diagnostic accuracy between different HR, BMI, and calcification subgroups (all P > 0.05) on a per-patient basis. However, low image quality reduced diagnostic accuracy on a per-patient, per-vessel and per-segment basis (all P < 0.05). The mean effective radiation dose was 0.2 ± 0.0 mSv. Our presented protocol results in an effective radiation dose of 0.2 mSv and high diagnostic accuracy for stenosis detection in a selected, non-obese population. (orig.)

  11. Detection of high mass cluster ions sputtered from Bi surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, A; Hewitt, R W; Slusser, G J; Baitinger, W E; Cooks, R G; Winograd, N [Purdue Univ., Lafayette, Ind. (USA). Dept. of Chemistry; Delgass, W N [Purdue Univ., Lafayette, Ind. (USA); Varon, A; Devant, G [Societe RIBER, 92 - Rueil-Malmaison (France)

    1976-12-01

    The technique of secondary ion mass spectrometry (SIMS) has been employed to detect Bi/sup 3 +/ ions and associated oxides Bi/sub 3/Osub(x)sup(+)(x=1 to 4) from a Bi foil. Using a 3 keV Ar/sup +/ ion primary beam of 5x10/sup -7/ A/cm/sup 2/, mass resolution to nearly 700 with the requisite sensitivity has been achieved. The Bi surface was also monitored by X-ray photoelectron spectroscopy (XPS or ESCA). The presence of a weak O 1s peak at 532.7 eV and a strong SIMS Bi/sup 3 +/ peak is interpreted to mean that the oxygen is weakly incorporated into the Bi lattice without disrupting metal-metal bonds.

  12. Contribution to high-temperature chromatography and high-temperature-gas-chromatography-mass spectrometry of lipids

    International Nuclear Information System (INIS)

    Aichholz, R.

    1998-04-01

    This thesis describes the use of high temperature gas chromatography for the investigation of unusual triacylglycerols, cyanolipids and bees waxes. The used glass capillary columns were pretreated and coated with tailor made synthesized high temperature stable polysiloxane phases. The selective separation properties of the individual columns were tested with a synthetic lipid mixture. Suitable derivatization procedures for the gaschromatographic analyses of neutral lipids, containing multiple bonds as well as hydroxy-, epoxy-, and carboxyl groups, were developed and optimized. Therefore conjugated olefinic-, conjugated olefinic-acetylenic-, hydroxy-, epoxy-, and conjugated olefinic keto triacylglycerols in miscellaneous plant seed oils as well as hydroxy monoesters, diesters and hydroxy diesters in bees waxes could be analysed directly with high temperature gas chromatography for the first time. In order to elucidate the structures of separated lipid compounds, high temperature gas chromatography was coupled to mass spectrometry and tandem mass spectrometry, respectively. Comparable analytical systems are hitherto not commercial available. Therefore instrumental prerequisites for a comprehensive and detailed analysis of seed oils and bees waxes were established. In GC/MS commonly two ionization methods are used, electron impact ionization and chemical ionization. For the analysis of lipids the first is of limited use only. Due to intensive fragmentation only weak molecular ions are observed. In contrast, the chemical ionization yields in better results. Dominant quasi molecular ions enable an unambiguous determination of the molecular weight. Moreover, characteristic fragment ions provide important indications of certain structural features of the examined compounds. Nevertheless, in some cases the chromatographic resolution was insufficient in order to separate all compounds present in natural lipid mixtures. Owing to the selected detection with mass spectrometry

  13. Electrostatic ion trap and Fourier transform measurements for high-resolution mass spectrometry

    International Nuclear Information System (INIS)

    Bhushan, K. G.; Gadkari, S. C.; Yakhmi, J. V.; Sahni, V. C.

    2007-01-01

    We report on the development of an electrostatic ion trap for high-resolution mass spectrometry. The trap works on purely electrostatic fields and hence trapping and storing of ions is not mass restrictive, unlike other techniques based on Penning, Paul, or radio frequency quadrupole ion traps. It allows simultaneous trapping and studying of multiple mass species over a large mass range. Mass spectra were recorded in ''dispersive'' and ''self-bunching'' modes of ions. Storage lifetimes of about 100 ms and mass resolving power of about 20 000 could be achieved from the fifth harmonic Fourier transform spectrum of Xe ions recorded in the self-bunching mode

  14. A high efficiency thermal ionization source adapted to mass spectrometers

    International Nuclear Information System (INIS)

    Chamberlin, E.P.; Olivares, J.A.

    1996-01-01

    A tungsten crucible thermal ionization source mounted on a quadrupole mass spectrometer is described. The crucible is a disposable rod with a fine hole bored in one end; it is heated by electron bombardment. The schematic design of the assembly, including water cooling, is described and depicted. Historically, the design is derived from that of ion sources used on ion separators at Los Alamos and Dubna, but the crucible is made smaller and simplified. 10 refs., 4 figs

  15. Long-wavelength negative mass instabilities in high current betatrons

    International Nuclear Information System (INIS)

    Godfrey, B.B.; Hughes, T.P.

    1985-01-01

    Growth rates of negative mass instabilities in conventional and modified betatrons are calculated by analytic methods and by performing three-dimensional particle simulations. In contrast to earlier work, toroidal corrections to the field equations are included in the analytic model. As a result, good agreement with numerical simulations is obtained. The simulations show that the nonlinear development of the instabilities can seriously disrupt the beam

  16. Multiresidue analysis of 22 sulfonamides and their metabolites in animal tissues using quick, easy, cheap, effective, rugged, and safe extraction and high resolution mass spectrometry (hybrid linear ion trap-Orbitrap).

    Science.gov (United States)

    Abdallah, H; Arnaudguilhem, C; Jaber, F; Lobinski, R

    2014-08-15

    A new high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) method was developed for a simultaneous multi-residue analysis of 22 sulfonamides (SAs) and their metabolites in edible animal (pig, beef, sheep and chicken) tissues. Sample preparation was optimized on the basis of the "QuEChERS" protocol. The analytes were identified using their LC retention times and accurate mass; the identification was further confirmed by multi-stage high mass accuracy (Pig kidney" with ǀ Z-scoreǀpig, beef, sheep, and chicken) allowing the simultaneous quantification of target sulfonamides at concentration levels above the MRL/2 and the identification of untargeted compounds such as N(4)-acetyl metabolites using multi-stage high mass accuracy mass spectrometry. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Discovery of putative salivary biomarkers for Sjögren's syndrome using high resolution mass spectrometry and bioinformatics.

    Science.gov (United States)

    Zoukhri, Driss; Rawe, Ian; Singh, Mabi; Brown, Ashley; Kublin, Claire L; Dawson, Kevin; Haddon, William F; White, Earl L; Hanley, Kathleen M; Tusé, Daniel; Malyj, Wasyl; Papas, Athena

    2012-03-01

    The purpose of the current study was to determine if saliva contains biomarkers that can be used as diagnostic tools for Sjögren's syndrome (SjS). Twenty seven SjS patients and 27 age-matched healthy controls were recruited for these studies. Unstimulated glandular saliva was collected from the Wharton's duct using a suction device. Two µl of salvia were processed for mass spectrometry analyses on a prOTOF 2000 matrix-assisted laser desorption/ionization orthogonal time of flight (MALDI O-TOF) mass spectrometer. Raw data were analyzed using bioinformatic tools to identify biomarkers. MALDI O-TOF MS analyses of saliva samples were highly reproducible and the mass spectra generated were very rich in peptides and peptide fragments in the 750-7,500 Da range. Data analysis using bioinformatic tools resulted in several classification models being built and several biomarkers identified. One model based on 7 putative biomarkers yielded a sensitivity of 97.5%, specificity of 97.8% and an accuracy of 97.6%. One biomarker was present only in SjS samples and was identified as a proteolytic peptide originating from human basic salivary proline-rich protein 3 precursor. We conclude that salivary biomarkers detected by high-resolution mass spectrometry coupled with powerful bioinformatic tools offer the potential to serve as diagnostic/prognostic tools for SjS.

  18. Molecular composition of organic aerosols in central Amazonia: an ultra-high-resolution mass spectrometry study

    OpenAIRE

    Kourtchev, I; Godoi, RHM; Connors, S; Levine, JG; Archibald, AT; Godoi, AFL; Paralovo, SL; Barbosa, CGG; Souza, RAF; Manzi, AO; Seco, R; Sjostedt, S; Park, J-H; Guenther, A; Kim, S

    2016-01-01

    The Amazon Basin plays key role in atmospheric chemistry, biodiversity and climate change. In this study we applied nanoelectrospray (nanoESI) ultra-high-resolution mass spectrometry (UHRMS) for the analysis of the organic fraction of PM$_{2.5}$ aerosol samples collected during dry and wet seasons at a site in central Amazonia receiving background air masses, biomass burning and urban pollution. Comprehensive mass spectral data evaluation methods (e.g. Kendrick mass defect, Van Krevelen diagr...

  19. Evaluation of a High Resolving Power Time-of-Flight Mass Spectrometer for Drug Analysis in Terms of Resolving Power and Acquisition Rate

    Science.gov (United States)

    Pelander, Anna; Decker, Petra; Baessmann, Carsten; Ojanperä, Ilkka

    2011-02-01

    Liquid chromatography time-of-flight mass spectrometry (LC-TOFMS) is applied increasingly to various fields of small molecule analysis. The moderate resolving power (RP) of standard TOFMS instruments poses a risk of false negative results when complex biological matrices are to be analyzed. In this study, the performance of a high resolving power TOFMS instrument (maXis by Bruker Daltonik, Bremen, Germany) was evaluated for drug analysis. By flow injection analysis of critical drug mixtures, including a total of 17 compounds with nominal masses of 212-415 Da and with mass differences of 8.8-23.5 mDa, RP varied from 34,400 to 51,900 (FWHM). The effect of acquisition rate on RP, mass accuracy, and isotopic pattern fit was studied by applying 1, 2, 5, 10, and 20 Hz acquisition rates in a 16 min gradient elution LC separation. All three variables were independent of the acquisition rate, with an average mass accuracy and isotopic pattern fit factor (mSigma) of 0.33 ppm and 5.9, respectively. The average relative standard deviation of RP was 1.8%, showing high repeatability. The performance was tested further with authentic urine extracts containing a co-eluting compound pair with a nominal mass of 296 Da and an 11.2 mDa mass difference. The authentic sample components were readily resolved and correctly identified by the automated data analysis. The average RP, mass accuracy, and isotopic pattern fit were 36,600, 0.9 ppm, and 7.3 mSigma, respectively.

  20. Snow cover volumes dynamic monitoring during melting season using high topographic accuracy approach for a Lebanese high plateau witness sinkhole

    Science.gov (United States)

    Abou Chakra, Charbel; Somma, Janine; Elali, Taha; Drapeau, Laurent

    2017-04-01

    Climate change and its negative impact on water resource is well described. For countries like Lebanon, undergoing major population's rise and already decreasing precipitations issues, effective water resources management is crucial. Their continuous and systematic monitoring overs long period of time is therefore an important activity to investigate drought risk scenarios for the Lebanese territory. Snow cover on Lebanese mountains is the most important water resources reserve. Consequently, systematic observation of snow cover dynamic plays a major role in order to support hydrologic research with accurate data on snow cover volumes over the melting season. For the last 20 years few studies have been conducted for Lebanese snow cover. They were focusing on estimating the snow cover surface using remote sensing and terrestrial measurement without obtaining accurate maps for the sampled locations. Indeed, estimations of both snow cover area and volumes are difficult due to snow accumulation very high variability and Lebanese mountains chains slopes topographic heterogeneity. Therefore, the snow cover relief measurement in its three-dimensional aspect and its Digital Elevation Model computation is essential to estimate snow cover volume. Despite the need to cover the all lebanese territory, we favored experimental terrestrial topographic site approaches due to high resolution satellite imagery cost, its limited accessibility and its acquisition restrictions. It is also most challenging to modelise snow cover at national scale. We therefore, selected a representative witness sinkhole located at Ouyoun el Siman to undertake systematic and continuous observations based on topographic approach using a total station. After four years of continuous observations, we acknowledged the relation between snow melt rate, date of total melting and neighboring springs discharges. Consequently, we are able to forecast, early in the season, dates of total snowmelt and springs low

  1. High-accuracy vibration sensor based on a Fabry-Perot interferometer with active phase-tracking technology.

    Science.gov (United States)

    Xia, Wei; Li, Chuncheng; Hao, Hui; Wang, Yiping; Ni, Xiaoqi; Guo, Dongmei; Wang, Ming

    2018-02-01

    A novel position-sensitive Fabry-Perot interferometer was constructed with direct phase modulation by a built-in electro-optic modulator. Pure sinusoidal phase modulation of the light was produced, and the first harmonic of the interference signal was extracted to dynamically maintain the interferometer phase to the most sensitive point of the interferogram. Therefore, the minute vibration of the object was coded on the variation of the interference signal and could be directly retrieved by the output voltage of a photodetector. The operating principle and the signal processing method for active feedback control of the interference phase have been demonstrated in detail. The developed vibration sensor was calibrated through a high-precision piezo-electric transducer and tested by a nano-positioning stage under a vibration magnitude of 60 nm and a frequency of 300 Hz. The active phase-tracking method of the system provides high immunity against environmental disturbances. Experimental results show that the proposed interferometer can effectively reconstruct tiny vibration waveforms with subnanometer resolution, paving the way for high-accuracy vibration sensing, especially for micro-electro-mechanical systems/nano-electro-mechanical systems and ultrasonic devices.

  2. High-Accuracy Tidal Flat Digital Elevation Model Construction Using TanDEM-X Science Phase Data

    Science.gov (United States)

    Lee, Seung-Kuk; Ryu, Joo-Hyung

    2017-01-01

    This study explored the feasibility of using TanDEM-X (TDX) interferometric observations of tidal flats for digital elevation model (DEM) construction. Our goal was to generate high-precision DEMs in tidal flat areas, because accurate intertidal zone data are essential for monitoring coastal environment sand erosion processes. To monitor dynamic coastal changes caused by waves, currents, and tides, very accurate DEMs with high spatial resolution are required. The bi- and monostatic modes of the TDX interferometer employed during the TDX science phase provided a great opportunity for highly accurate intertidal DEM construction using radar interferometry with no time lag (bistatic mode) or an approximately 10-s temporal baseline (monostatic mode) between the master and slave synthetic aperture radar image acquisitions. In this study, DEM construction in tidal flat areas was first optimized based on the TDX system parameters used in various TDX modes. We successfully generated intertidal zone DEMs with 57-m spatial resolutions and interferometric height accuracies better than 0.15 m for three representative tidal flats on the west coast of the Korean Peninsula. Finally, we validated these TDX DEMs against real-time kinematic-GPS measurements acquired in two tidal flat areas; the correlation coefficient was 0.97 with a root mean square error of 0.20 m.

  3. Uncertainties and Systematic Effects on the estimate of stellar masses in high z galaxies

    Science.gov (United States)

    Salimbeni, S.; Fontana, A.; Giallongo, E.; Grazian, A.; Menci, N.; Pentericci, L.; Santini, P.

    2009-05-01

    We discuss the uncertainties and the systematic effects that exist in the estimates of the stellar masses of high redshift galaxies, using broad band photometry, and how they affect the deduced galaxy stellar mass function. We use at this purpose the latest version of the GOODS-MUSIC catalog. In particular, we discuss the impact of different synthetic models, of the assumed initial mass function and of the selection band. Using Chariot & Bruzual 2007 and Maraston 2005 models we find masses lower than those obtained from Bruzual & Chariot 2003 models. In addition, we find a slight trend as a function of the mass itself comparing these two mass determinations with that from Bruzual & Chariot 2003 models. As consequence, the derived galaxy stellar mass functions show diverse shapes, and their slope depends on the assumed models. Despite these differences, the overall results and scenario is observed in all these cases. The masses obtained with the assumption of the Chabrier initial mass function are in average 0.24 dex lower than those from the Salpeter assumption, at all redshifts, causing a shift of galaxy stellar mass function of the same amount. Finally, using a 4.5 μm-selected sample instead of a Ks-selected one, we add a new population of highly absorbed, dusty galaxies at z~=2-3 of relatively low masses, yielding stronger constraints on the slope of the galaxy stellar mass function at lower masses.

  4. Arsenic speciation in soil using high performance liquid chromatography/inductively coupled plasma/mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Bass, D.A.; Yaeger, J.S.; Parish, K.J.; Crain, J.S.; Kiely, J.T.; Gowdy, M.J. [Argonne National Lab., IL (United States); Mohrman, G.B.; Besmer, M.G. [Rocky Mountain Arsenal, Commerce City, CO (United States)

    1996-08-01

    A method has been developed to identify and quantify As(III), As(V), and organoarsenic compounds in soil samples from the Rocky Mountain Arsenal (RMA) by high performance liquid chromatography/inductively coupled plasma/mass spectrometry (HPLC/ICP/MS). The soils were extracted using tetrabutylammonium hydroxide (TBAH) and sonication. The percentages of As(III), As(V), and organoarsenic species extracted from soil samples were 30, 50, and 100 respectively. The arsenic species were not altered during the extraction process. They were separated by reversed-phase, ion-pairing, HPLC using a microbore Inertsil-ODS{trademark} column. The HPLC column effluent was introduced into an ICP/MS system using a direct injection nebulizer (DIN). Detection limits of less than 1 pg were readily obtained for each arsenic species. Internal standards are recommended to increase accuracy and precision. Soil samples spiked with arsenic oxide, sodium arsenate, dimethylarsinic acid (DMAA), and chlorovinyl arsenious acid (CVAA) were extracted, identified and quantified with the HPLC/ICP/MS system. The soil samples were analyzed in support of the analytical needs of a thermal desorption treatability study being conducted at the RMA.

  5. The photon PDF from high-mass Drell-Yan data at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Giuli, F.; Cooper-Sarkar, A. [University of Oxford, Oxford, OX1 3NP (United Kingdom); Bertone, V.; Rojo, J. [VU University, Department of Physics and Astronomy, Amsterdam (Netherlands); Nikhef Theory Group Science Park 105, Amsterdam (Netherlands); Britzger, D.; Glazov, A.; Zenaiev, O. [DESY Hamburg, Hamburg (Germany); Carrazza, S. [CERN, Geneva 23 (Switzerland); Lohwasser, K. [DESY Zeuthen, Zeuthen (Germany); Luszczak, A. [T. Kosciuszko Cracow University of Technology, Cracow (Poland); Olness, F. [SMU Physics, Box 0175, Dallas, TX (United States); Placakyte, R. [Universitaet Hamburg, Institut fuer Theoretische Physik, Hamburg (Germany); Radescu, V. [University of Oxford, Oxford, OX1 3NP (United Kingdom); CERN, Geneva 23 (Switzerland); Sadykov, R.; Shvydkin, P. [Joint Institute for Nuclear Research (JINR), Dubna, Moscow Region (Russian Federation); Lisovyi, M. [Ruprecht-Karls-Universitaet Heidelberg, Physikalisches Institut, Heidelberg (Germany); Collaboration: xFitter Developers' team

    2017-06-15

    Achieving the highest precision for theoretical predictions at the LHC requires the calculation of hard-scattering cross sections that include perturbative QCD corrections up to (N)NNLO and electroweak (EW) corrections up to NLO. Parton distribution functions (PDFs) need to be provided with matching accuracy, which in the case of QED effects involves introducing the photon parton distribution of the proton, xγ(x,Q{sup 2}). In this work a determination of the photon PDF from fits to recent ATLAS measurements of high-mass Drell-Yan dilepton production at √(s) = 8 TeV is presented. This analysis is based on the xFitter framework, and has required improvements both in the APFEL program, to account for NLO QED effects, and in the aMCfast interface to account for the photon-initiated contributions in the EW calculations within MadGraph5aMC rate at NLO. The results are compared with other recent QED fits and determinations of the photon PDF, consistent results are found. (orig.)

  6. Determination of high molecular mass compounds from Amazonian plant's leaves

    International Nuclear Information System (INIS)

    Siqueira, Denilson Soares de; Pereira, Alberto dos Santos; Aquino Neto, Francisco Radler de; Simoneit, Bernd R.T.

    2003-01-01

    The fractions of dichloromethane extracts of leaves from andiroba (Carapa guianensis - Meliaceae), caapi (Banisteriopsis caapi - Malpighiaceae), cocoa (Theobroma cacao - Sterculiaceae), Brazil nut (Bertholletia excelsa - Lecytidaceae), cupuacu (Theobroma grandiflorum - Sterculiaceae), marupa (Simaruba amara - Simaroubaceae) and rubber tree (Hevea brasiliensis - Euphorbiaceae), were analyzed by HT-HRGC and HT-HRGC-MS. Esters of homologous series of fatty acids and long chain alcohols, phytol, amyrines and tocopherols were characterized. The characterization of the compounds was based mainly in mass spectra data and in addition by usual spectrometric data ( 1 H and 13 C NMR, IR). (author)

  7. High Performance Low Mass Nanowire Enabled Heatpipe, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Heat pipes are widely used for passive, two-phase electronics cooling. As advanced high power, high performance electronics in space based and terrestrial...

  8. THE IMPACT OF MODERATE AND HIGH INTENSITY TOTAL BODY FATIGUE ON PASSING ACCURACY IN EXPERT AND NOVICE BASKETBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Mark Lyons

    2006-06-01

    Full Text Available Despite the acknowledged importance of fatigue on performance in sport, ecologically sound studies investigating fatigue and its effects on sport-specific skills are surprisingly rare. The aim of this study was to investigate the effect of moderate and high intensity total body fatigue on passing accuracy in expert and novice basketball players. Ten novice basketball players (age: 23.30 ± 1.05 yrs and ten expert basketball players (age: 22.50 ± 0.41 yrs volunteered to participate in the study. Both groups performed the modified AAHPERD Basketball Passing Test under three different testing conditions: rest, moderate intensity and high intensity total body fatigue. Fatigue intensity was established using a percentage of the maximal number of squat thrusts performed by the participant in one minute. ANOVA with repeated measures revealed a significant (F 2,36 = 5.252, p = 0.01 level of fatigue by level of skill interaction. On examination of the mean scores it is clear that following high intensity total body fatigue there is a significant detriment in the passing performance of both novice and expert basketball players when compared to their resting scores. Fundamentally however, the detrimental impact of fatigue on passing performance is not as steep in the expert players compared to the novice players. The results suggest that expert or skilled players are better able to cope with both moderate and high intensity fatigue conditions and maintain a higher level of performance when compared to novice players. The findings of this research therefore, suggest the need for trainers and conditioning coaches in basketball to include moderate, but particularly high intensity exercise into their skills sessions. This specific training may enable players at all levels of the game to better cope with the demands of the game on court and maintain a higher standard of play

  9. [Screening and confirmation of 24 hormones in cosmetics by ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry].

    Science.gov (United States)

    Li, Zhaoyong; Wang, Fengmei; Niu, Zengyuan; Luo, Xin; Zhang, Gang; Chen, Junhui

    2014-05-01

    A method of ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry (UPLC-LTQ/Orbitrap MS) was established to screen and confirm 24 hormones in cosmetics. Various cosmetic samples were extracted with methanol. The extract was loaded onto a Waters ACQUITY UPLC BEH C18 column (50 mm x 2.1 mm, 1.7 microm) using a gradient elution of acetonitrile/water containing 0.1% (v/v) formic acid for the separation. The accurate mass of quasi-molecular ion was acquired by full scanning of electrostatic field orbitrap. The rapid screening was carried out by the accurate mass of quasi-molecular ion. The confirmation analysis for targeted compounds was performed with the retention time and qualitative fragments obtained by data dependent scan mode. Under the optimal conditions, the 24 hormones were routinely detected with mass accuracy error below 3 x 10(-6) (3 ppm), and good linearities were obtained in their respective linear ranges with correlation coefficients higher than 0.99. The LODs (S/N = 3) of the 24 compounds were hormones in 50 cosmetic samples. The results demonstrate that the method is a useful tool for the rapid screening and identification of the hormones in cosmetics.

  10. The Evolution of High-Mass Star-Forming Cores in the Nessie Nebula

    Science.gov (United States)

    Jackson, James; Rathborne, Jill; Sanhueza, Patricio; Whitaker, John Scott; Camarata, Matthew

    2013-04-01

    We aim to deduce the evolution of the ensemble properties of high-mass star-forming cores within a cluster-forming molecular clump. Two different theories of high-mass star-formation, "competitive accretion" and "monolithic collapse" make very different predictions for this evolution. In "competitive accretion" the clump will contain only low-mass cores in the early phases, and high-mass cores will be found in the later stages. In "monolithic collapse" high-mass cores are found early on, and the mass distribution of the cores will remain essentially unchanged. Both models predict cores to increase in temperature. We can classify evolutionary stage from Spitzer mid-IR images. We choose to study 6 cores in the Nessie nebula that span the complete range of protostellar evolution. Nessie is an ideal laboratory because all the cores are at the same distance and in the same Galactic environment.

  11. HIGH ANGULAR RESOLUTION OBSERVATIONS OF FOUR CANDIDATE BLAST HIGH-MASS STARLESS CORES

    International Nuclear Information System (INIS)

    Olmi, Luca; Poventud, Carlos M.; Araya, Esteban D.; Chapin, Edward L.; Gibb, Andrew; Hofner, Peter; Martin, Peter G.

    2010-01-01

    We discuss high angular resolution observations of ammonia toward four candidate high-mass starless cores (HMSCs). The cores were identified by the Balloon-borne Large Aperture Submillimeter Telescope (BLAST) during its 2005 survey of the Vulpecula region where 60 compact sources were detected simultaneously at 250, 350, and 500 μm. Four of these cores, with no IRAS-PSC or MSX counterparts, were mapped with the NRAO Very Large Array and observed with the Effelsberg 100 m telescope in the NH 3 (1,1) and (2,2) spectral lines. Our observations indicate that the four cores are cold (T k -1 . The four BLAST cores appear to be colder and more quiescent than other previously observed HMSC candidates, suggesting an earlier stage of evolution.

  12. Production cross-sections for high mass particles and transverse momentum spectra

    International Nuclear Information System (INIS)

    Arnold, R.C.; Halzen, F.

    1977-06-01

    The concept of transverse-mass (msub(T)) scaling is examined. It is suggested that: (1) experimental data on pion transverse momentum (psub(T)) spectra provide a reliable guide to expectations for high mass particle production; (2) dimensional scaling, e.g. implied by quark-gluon dynamics, yields an estimate of msub(T) -4 spectra at ultra-high energies; however, stronger damping is expected at currently accessible energies; (3) values increase linearly with the produced particle mass. The results of msub(T) scaling are compared with estimates for high mass production in the context of the Drell-Yan model. (author)

  13. High-accuracy determination of the neutron flux in the new experimental area nTOF-EAR2 at CERN

    Energy Technology Data Exchange (ETDEWEB)

    Sabate-Gilarte, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Universidad de Sevilla, Departamento de Fisica Atomica, Molecular y Nuclear, Sevilla (Spain); Barbagallo, M.; Colonna, N.; Damone, L.; Belloni, F.; Mastromarco, M.; Tagliente, G.; Variale, V. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari (Italy); Gunsing, F.; Berthoumieux, E.; Diakaki, M.; Papaevangelou, T.; Dupont, E. [Universite Paris-Saclay, CEA Irfu, Gif-sur-Yvette (France); Zugec, P.; Bosnar, D. [University of Zagreb, Department of Physics, Faculty of Science, Zagreb (Croatia); Vlachoudis, V.; Aberle, O.; Brugger, M.; Calviani, M.; Cardella, R.; Cerutti, F.; Chiaveri, E.; Ferrari, A.; Kadi, Y.; Losito, R.; Macina, D.; Montesano, S.; Rubbia, C. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Chen, Y.H.; Audouin, L.; Tassan-Got, L. [Centre National de la Recherche Scientifique/IN2P3 - IPN, Orsay (France); Stamatopoulos, A.; Kokkoris, M.; Tsinganis, A.; Vlastou, R. [National Technical University of Athens (NTUA), Athens (Greece); Lerendegui-Marco, J.; Cortes-Giraldo, M.A.; Guerrero, C.; Quesada, J.M. [Universidad de Sevilla, Departamento de Fisica Atomica, Molecular y Nuclear, Sevilla (Spain); Villacorta, A. [University of Salamanca, Salamanca (Spain); Cosentino, L.; Finocchiaro, P.; Piscopo, M. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Musumarra, A. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Universita di Catania, Dipartimento di Fisica, Catania (Italy); Andrzejewski, J.; Gawlik, A.; Marganiec, J.; Perkowski, J. [University of Lodz, Lodz (Poland); Becares, V.; Balibrea, J.; Cano-Ott, D.; Garcia, A.R.; Gonzalez, E.; Martinez, T.; Mendoza, E. [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain); Bacak, M.; Weiss, C. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Technische Universitaet Wien, Wien (Austria); Baccomi, R.; Milazzo, P.M. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, Trieste (Italy); Barros, S.; Ferreira, P.; Goncalves, I.F.; Vaz, P. [Instituto Superior Tecnico, Lisbon (Portugal); Becvar, F.; Krticka, M.; Valenta, S. [Charles University, Prague (Czech Republic); Beinrucker, C.; Goebel, K.; Heftrich, T.; Reifarth, R.; Schmidt, S.; Weigand, M.; Wolf, C. [Goethe University Frankfurt, Frankfurt (Germany); Billowes, J.; Frost, R.J.W.; Ryan, J.A.; Smith, A.G.; Warren, S.; Wright, T. [University of Manchester, Manchester (United Kingdom); Caamano, M.; Deo, K.; Duran, I.; Fernandez-Dominguez, B.; Leal-Cidoncha, E.; Paradela, C.; Robles, M.S. [University of Santiago de Compostela, Santiago de Compostela (Spain); Calvino, F.; Casanovas, A.; Riego-Perez, A. [Universitat Politecnica de Catalunya, Barcelona (Spain); Castelluccio, D.M.; Lo Meo, S. [Agenzia Nazionale per le Nuove Tecnologie (ENEA), Bologna (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Bologna, Bologna (Italy); Cortes, G.; Mengoni, A. [Agenzia Nazionale per le Nuove Tecnologie (ENEA), Bologna (Italy); Domingo-Pardo, C.; Tain, J.L. [Universidad de Valencia, Instituto de Fisica Corpuscular, Valencia (Spain); Dressler, R.; Heinitz, S.; Kivel, N.; Maugeri, E.A.; Schumann, D. [Paul Scherrer Institut (PSI), Villingen (Switzerland); Furman, V.; Sedyshev, P. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Gheorghe, I.; Glodariu, T.; Mirea, M.; Oprea, A. [Horia Hulubei National Institute of Physics and Nuclear Engineering, Magurele (Romania); Goverdovski, A.; Ketlerov, V.; Khryachkov, V. [Institute of Physics and Power Engineering (IPPE), Obninsk (Russian Federation); Griesmayer, E.; Jericha, E.; Kavrigin, P.; Leeb, H. [Technische Universitaet Wien, Wien (Austria); Harada, H.; Kimura, A. [Japan Atomic Energy Agency (JAEA), Tokai-mura (Japan); Hernandez-Prieto, A. [European Organization for Nuclear Research (CERN), Geneva (CH); Universitat Politecnica de Catalunya, Barcelona (ES); Heyse, J.; Schillebeeckx, P. [European Commission, Joint Research Centre, Geel (BE); Jenkins, D.G. [University of York, York (GB); Kaeppeler, F. [Karlsruhe Institute of Technology, Karlsruhe (DE); Katabuchi, T. [Tokyo Institute of Technology, Tokyo (JP); Lederer, C.; Lonsdale, S.J.; Woods, P.J. [University of Edinburgh, School of Physics and Astronomy, Edinburgh (GB); Licata, M.; Massimi, C.; Vannini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Bologna, Bologna (IT); Universita di Bologna, Dipartimento di Fisica e Astronomia, Bologna (IT); Mastinu, P. [Istituto Nazionale di Fisica Nucleare, Sezione di Legnaro, Legnaro (IT); Matteucci, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, Trieste (IT); Universita di Trieste, Dipartimento di Astronomia, Trieste (IT); Mingrone, F. [European Organization for Nuclear Research (CERN), Geneva (CH); Istituto Nazionale di Fisica Nucleare, Sezione di Bologna, Bologna (IT); Nolte, R. [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (DE); Palomo-Pinto, F.R. [Universidad de Sevilla, Dept. Ingenieria Electronica, Escuela Tecnica Superior de Ingenieros, Sevilla (ES); Patronis, N. [University of Ioannina, Ioannina (GR); Pavlik, A. [University of Vienna, Faculty of Physics, Vienna (AT); Porras, J.I. [University of Granada, Granada (ES); Praena, J. [Universidad de Sevilla, Departamento de Fisica Atomica, Molecular y Nuclear, Sevilla (ES); University of Granada, Granada (ES); Rajeev, K.; Rout, P.C.; Saxena, A.; Suryanarayana, S.V. [Bhabha Atomic Research Centre (BARC), Mumbai (IN); Rauscher, T. [University of Hertfordshire, Centre for Astrophysics Research, Hatfield (GB); University of Basel, Department of Physics, Basel (CH); Tarifeno-Saldivia, A. [Universitat Politecnica de Catalunya, Barcelona (ES); Universidad de Valencia, Instituto de Fisica Corpuscular, Valencia (ES); Ventura, A. [Istituto Nazionale di Fisica Nucleare, Sezione di Bologna, Bologna (IT); Wallner, A. [Australian National University, Canberra (AU)

    2017-10-15

    A new high flux experimental area has recently become operational at the nTOF facility at CERN. This new measuring station, nTOF-EAR2, is placed at the end of a vertical beam line at a distance of approximately 20 m from the spallation target. The characterization of the neutron beam, in terms of flux, spatial profile and resolution function, is of crucial importance for the feasibility study and data analysis of all measurements to be performed in the new area. In this paper, the measurement of the neutron flux, performed with different solid-state and gaseous detection systems, and using three neutron-converting reactions considered standard in different energy regions is reported. The results of the various measurements have been combined, yielding an evaluated neutron energy distribution in a wide energy range, from 2 meV to 100 MeV, with an accuracy ranging from 2%, at low energy, to 6% in the high-energy region. In addition, an absolute normalization of the nTOF-EAR2 neutron flux has been obtained by means of an activation measurement performed with {sup 197}Au foils in the beam. (orig.)